[The effect of the gas hypoxic mixture GHM-8 on the capacity of the stromal clonogenic cells (CFU-F) in rat bone marrow for postradiation recovery].
The effect of gas hypoxic mixture, containing 8% of O2 (GHM-8), on the ability of cell precursors of haemopoietic stroma (which form colonies (clones) of fibroblasts (CFU-F) in a culture, and are present in the bone marrow of adult rats) to repair potentially lethal and sublethal radiation damages has been investigated. The recovery of CFU-F from potentially lethal damages, that was studied after their delayed survival in a culture following irradiation of animals, proceeds at nearly the same rate in cells irradiated both in the air and in hypoxic conditions (GHM-8). Fractionated irradiation reduces the radioprotective effect of GHM-8 for CFU-F, particularly for the radioresistant subpopulation; the ability of CFU-F to recover from sublethal radiation damages decreases.
A G
AG
Konopliannikov
A A
AA
Waĭnson
A I
AI
Kolesnikova
V A
VA
Zaĭtsev
S Sh
SSh
Kal'sina
L A
LA
Lepekhina
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects*; D001854:Bone Marrow Cells; D015687:Cell Hypoxia / Q000187:drug effects / Q000528:radiation effects; D002999:Clone Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D011837:Radiation-Protective Agents; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
Vliianie gazovoĭ gipoksicheskoĭ smesi GGS-8 na sposobnost' stromal'nykh klonogennykh kletok (KOE-F) kostnogo mozga krys k postradiatsionnomu vosstanovleniiu.