Variations of protein C in uremic hemodialysed patients.
Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagulant activity of protein C has been found impaired in eight cases whereas other inhibitors were normal. In four cases, both anticoagulant and antigenic levels were low. In one case, amidolytic method could also found a low activity. Hemodialysis leads to an increase of protein C activity and antigen level. Heparinemia after hemodialysis does not interfere with the chronometric measurement of protein C anticoagulant activity. Total protein level, hematocrit, protein S and antithrombin III are also elevated after hemodialysis. Baseline fibrinolytic parameters are normal and remain unchanged after hemodialysis. The clinical relevance of such modifications is discussed.
Nguyen
P
P
Laboratoire central d'Hématologie, CHU, Reims.
Toupance
O
O
Chanard
J
J
Potron
G
G
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis; D020151:Protein C Deficiency; D017293:Protein S / Q000032:analysis; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D001798:Blood Proteins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III