Maternal nicotine exposure during pregnancy and development of emphysema-like damage in the offspring.
The aim of this investigation was to determine whether nicotine exposure (1 mg/kg body mass/d) during pregnancy and lactation contributes to the rupturing of alveolar septa in the lungs of neonatal rats. These rats received nicotine only via the placenta and mother's milk. The results show that maternal nicotine exposure interferes with elastic tissue formation. It also interferes with alveoli formation and causes the development of emphysema-like lesions. It is therefore suggested that maternal nicotine intake from smoking during pregnancy and lactation may interfere with lung development and maturation to an extent that increases susceptibility to emphysema.
Department of Physiological Sciences, University of the Western Cape, Bellville, CP.
G S
GS
Maritz
K M
KM
Woolward
G
G
du Toit
D000818:Animals; D004548:Elasticity; D004646:Emphysema / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D007774:Lactation; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D009538:Nicotine / Q000009:adverse effects*; D011247:Pregnancy; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000254:growth & development / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors
D009538:Nicotine