[Cancer of the gallbladder. Epidemiology, diagnosis and prognostic factors].
Between 1978 and 1986, 77 cases of primary gallbladder carcinoma were recorded in the Calvados Digestive tumors Registry (covering a population of 589,559 inhabitants) among 125 extra-hepatic bile duct carcinomas. The crude incidence was 2.4/100,000 in females and 0.6 in males (sex-ratio = 3.8). Cholelithiasis was demonstrated in 81.3%. Gallbladder carcinoma was diagnosed correctly preoperatively in only 13.5%. Out of the 74 operated patients, there were only 6 mucosal or sub-mucosal carcinomas and liver involvement was present in 40%. Diagnosis was made post-operatively on the resected specimen in 13 patients (non reoperated) Operative mortality was 24%. The overall survival was 14.7% at one year, 4% at 5 years (median = 3 months). In multivariate analysis the prognostic factors were: curative resection (9 patients, 3-year survival: 55%), parietal extension, liver involvement. No significant trend in prognosis could be demonstrated during the study period.
Registre des Tumeurs Digestives du Calvados.
G
G
Launoy
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E
Crenes-Laventure
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T
Dao
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D
Pottier
A
A
Rougereau
J C
JC
Verwaede
M
M
Gignoux
D000206:Actuarial Analysis; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000601:surgery; D002763:Cholecystectomy; D005260:Female; D005602:France; D005706:Gallbladder Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000601:surgery; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis
Le cancer de la vésicule biliaire. Epidémiologie, diagnostic et facteurs pronostiques.