The luteal phase after ovulation induction with human menopausal gonadotropin and one versus two doses of a gonadotropin-releasing hormone agonist.
OBJECTIVE
To use a GnRH agonist (GnRH-a) to induce ovulation after priming with exogenous hMG.


METHODS
Prospective, randomized double-blind protocol using one or two doses of intranasal nafarelin.


METHODS
Office-based ovulation induction program. PATIENTS, INTERVENTIONS: Infertile women not conceiving after use of clomiphene citrate for at least 6 months who were given hMG and nafarelin. No luteal support was given.


METHODS
Serum concentrations of FSH, LH, E2, and P acutely and at 6 days after GnRH-a administration. Duration of the luteal phase was assessed.


RESULTS
Ovulation with elevation of both FSH and LH was achieved. The two-dose regimen was more effective than one dose for sustained LH release. Luteal phase P values and luteal phase duration were both less than usually seen with gonadotropin hCG therapy in the absence of luteal phase support.


CONCLUSIONS
Ovulation induction with GnRH-a after hMG priming produces unacceptable luteal phase cycles in the absence of hormonal support.
Department of Obstetrics and Gynecology, Pennsylvania Hospital.
S L
SL
Corson
F R
FR
Batzer
B
B
Gocial
G
G
Maislin
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000097:blood; D017274:Nafarelin / Q000627:therapeutic use; D010062:Ovulation Induction; D011374:Progesterone / Q000097:blood; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives*
D006063:Chorionic Gonadotropin; D017329:Triptorelin Pamoate; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; C019176:Tryptal; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone