WWamide-1, -2 and -3: novel neuromodulatory peptides isolated from ganglia of the African giant snail, Achatina fulica.
Three novel neuropeptides, isolated from ganglia of the African giant snail, Achatina fulica, were named WWamide-1, -2 and -3. These substances were biologically active heptapeptide amides with a Trp residue at both the N- and C-termini. WWamide-1, which displayed an inhibitory activity on a central neuron of the snail, exhibited peripherally modulatory effects on muscular contractions of not only the gut and other tissues of the snail but also certain tissues of other molluscs.
Suntory Institute for Bioorganic Research, Osaka, Japan.
H
H
Minakata
T
T
Ikeda
Y
Y
Muneoka
M
M
Kobayashi
K
K
Nomoto
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008969:Molecular Sequence Data; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology; D009479:Neuropeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000502:physiology; D009842:Oligopeptides / Q000302:isolation & purification; D012908:Snails
D000596:Amino Acids; D009479:Neuropeptides; D009842:Oligopeptides; C081317:H-tryptophyl-arginyl-glutamyl-methionyl-seryl-valyl-tryptophylamide; C081319:H-tryptophyl-lysyl-glutaminyl-methionyl-seryl-valyl-tryptophylamide; C081318:H-tryptophyl-lysyl-glutamyl-methionyl-seryl-valyl-tryptophylamide