Dopamine agonist treatment of antegrade amnesia from a mediobasal forebrain injury.
We studied the persistent antegrade memory impairment in a woman whose brain had been surgically impaled, leaving a 1-cm-wide mediobasal tract of encephalomalacia that extended just anterior to the septal nuclei and medial to the nucleus accumbens. In a blinded, controlled, alternating repeated-measures protocol, bromocriptine significantly improved her verbal learning, functional memory, and daily recall, perhaps by acting on neurons that had been disconnected from the ventral tegmental tract's dopaminergic inputs.
School of Medicine, Department of Neurology, University of California, Los Angeles 90024-6975.
B H
BH
Dobkin
R
R
Hanlon
D000328:Adult; D000647:Amnesia / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D001930:Brain Injuries / Q000150:complications*; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009483:Neuropsychological Tests; D016548:Prosencephalon / Q000293:injuries*; D014888:Wechsler Scales
D001971:Bromocriptine