Non-linear regression and variance ratio analysis of time based NMR data.
Biomedical NMR experiments rely frequently on data obtained sequentially over time. A method is presented for analysis of time based NMR data, which allows modelling of continuous and discontinuous functions to observed intensity changes by non-linear regression and which uses variance ratio analysis to compare these models statistically. The method eliminates many of the usual problems in the parametric analysis of experimental values obtained at discrete time points and of comparison of the coefficients of model functions which require unsubstantiated assumptions about the distribution of parameters and ignore internal correlations which may exist between such parameters. The variance ratio method is illustrated for multiple time courses obtained with 23Na NMR of perfused rat kidney undergoing hypoxic perturbation in the presence of different treatments.
Department of Medicine, University of Queensland, Brisbane, Australia.
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Duggleby
D000596:Amino Acids / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D016166:Free Radical Scavengers; D000860:Hypoxia / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D012964:Sodium / Q000378:metabolism; D012984:Software; D013997:Time Factors
D000596:Amino Acids; D016166:Free Radical Scavengers; D012964:Sodium