Norethindrone--a review of therapeutic applications.
Norethindrone is utilized for numerous noncontraceptive therapies, especially during the menopause. Through an analysis of the literature we have described the pharmacological profile of norethindrone and the potential therapeutic implications of low-dose therapies, with an emphasis on endometrial pathology, climacteric symptoms, lipid metabolism, and bone density.
Ortho-McNeil Pharmaceutical Raritan, New Jersey, USA.
H F
HF
Taitel
M E
ME
Kafrissen
D000328:Adult; D015519:Bone Density / Q000502:physiology; D002979:Climacteric / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008593:Menopause / Q000378:metabolism / Q000502:physiology*; D008875:Middle Aged; D009640:Norethindrone / Q000493:pharmacokinetics / Q000592:standards / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D045167:Progesterone Congeners / Q000493:pharmacokinetics / Q000592:standards / Q000627:therapeutic use*; D014592:Uterine Hemorrhage / Q000517:prevention & control
D045167:Progesterone Congeners; D009640:Norethindrone