Extracorporeal immunopharmacotherapy in patients with chronic septic cholangitis.
An immunological examination of patients with septic cholangitis revealed secondary immunodeficiency. Traditional methods of therapy and immunocorrection were ineffective in eight patients with septic cholangitis. They were treated with extracorporeal immunopharmacotherapy using diuciphon. For the accomplishing detoxication, this was used in combination with plasma exchange. The course of treatment consisted of 3 or 4 procedures, within a 3- or 4-day interval. As a result of extracorporeal immunocorrection, patients were observed to have positive immunological indexes, demonstrated by the normalization of the lymphocyte count in 5 of 6 patients, CD3+ and CD4+ in 3 patients, and CD8+ in 4. Four patients had clinical remissions (0.5 year), and 3 patients underwent surgery with no septic postoperative complications.
Institute of Immunology, Russian Ministry of Public Health, Moscow.
R M
RM
Khaitov
E I
EI
Galperin
N P
NP
Podobin
V P
VP
Leskov
E S
ES
Fedenko
N S
NS
Prosorovsky
G G
GG
Akhaladze
V P
VP
Prokopenko
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002761:Cholangitis / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D013450:Sulfones / Q000627:therapeutic use*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D013450:Sulfones; C023367:diucifon; D014498:Uracil