Mechanisms of glycation in atherogenesis.
Non-enzymatic glycation may affect the arterial wall altering its connective tissue and promoting LDL accumulation. Its recognition by specific receptors and growth factor release, as well as possible alteration of DNA, may stimulate smooth muscle cell proliferation. Free radical generation may favour non-enzymatic PUFA degradation and quench NO, which would alter vascular relaxation. All of these aspects may participate in atherogenesis.
Dpt Ciències Mèdiques Bàsiques, Faculty of Medicine, University of Lleida, Spain.
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Pamplona
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Bellmunt
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Portero
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Prat
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D003238:Connective Tissue / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000378:metabolism
D017127:Glycation End Products, Advanced; D008077:Lipoproteins, LDL; D005947:Glucose