The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.
The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chromatin folding.
Institut National de la Santé et de la Recherche Médicale U124-IRCL, Lille, France.
O
O
Albagli
P
P
Dhordain
C
C
Deweindt
G
G
Lecocq
D
D
Leprince
D000595:Amino Acid Sequence; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004330:Drosophila; D008840:Microfilament Proteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000378:metabolism*; D016335:Zinc Fingers
D002843:Chromatin; D004268:DNA-Binding Proteins; D008840:Microfilament Proteins; D009687:Nuclear Proteins; D014764:Viral Proteins