The pattern of faecal egg output in lambs infected with a multiple resistant strain of Haemonchus contortus after treatment with albendazole.
Worm-free lambs (n = 6) were infected with 5,000 L3 of an ivermectin/benzimidazole/closantel resistant strain of Haemonchus contortus. On Day 21 post infection animals were allocated, according to worm egg counts, to 2 groups of 3 animals each and on Day 29 one group was treated with albendazole at 3.8 mg kg-1, while animals in the other group remained untreated as controls. All animals were slaughtered on Day 44 when the treated group was found to have 2,083 +/- 1,718 worms and the controls 2,783 +/- 633, a reduction of 25.2% in worm burdens. The pattern of egg output was monitored and it was found that 2 d after dosing, worm egg counts had been suppressed by 89% in the treated group; thereafter the egg counts increased, but never returned to the pretreatment levels and by Day 15 post treatment, they were still 41.1% lower in the treated group than in the controls.
Department of Veterinary Parasitology, University of Glasgow.
F A
FA
Echevarria
J
J
Armour
K
K
Bairden
J L
JL
Duncan
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology*; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology*
D015766:Albendazole