Comparison of the satiating potencies of cholecystokinin-33 and cholecystokinin-8.
We investigated the satiating potency of CCK-33 and of CCK-8 administered IP to rats prior to a 30-min food intake test using a high-carbohydrate liquid diet. CCK-33 and CCK-8 produced dose-related inhibitions of intake. The ID50S and the slopes of the dose-response functions of the two peptides were not significantly different. We conclude that CCK-33 is as potent as CCK-8 for inhibiting food intake in the rat.
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
L D
LD
Melville
G P
GP
Smith
J
J
Gibbs
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012528:Satiety Response / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology*; D013552:Swine
D004040:Dietary Carbohydrates; D002766:Cholecystokinin; D012844:Sincalide