Sucrose: a novel permeability marker for gastroduodenal disease.
BACKGROUND
Nonsteroidal anti-inflammatory agents (NSAIDs) commonly cause asymptomatic gastroduodenal damage that may be clinically severe. At present the only method to determine the presence or absence of such damage is by invasive techniques such as endoscopy. Because distal small intestinal damage can be noninvasively detected with oral permeability tests, the hypothesis that gastroduodenal damage could be detected using similar methods was examined in the present study.


RESULTS
Animal data are presented suggesting that sucrose represents an ideal probe molecule to detect increased gastroduodenal permeability in a site-specific manner. With gastroduodenal damage, caused by either ethanol or NSAIDs, sucrose permeability is increased. Furthermore, because sucrose is rapidly degraded within the small intestine, this probe does not detect small intestinal damage, making it specific for the upper gastrointestinal tract. Finally, a pilot study in humans is presented to show the use of this technique in evaluating human gastric permeability.


CONCLUSIONS
Sucrose represents a novel permeability probe with specificity for damage of the upper gastrointestinal tract. In animals and humans it appears useful to noninvasively detect gastroduodenal injury caused by several agents.
Gastrointestinal Research Group, University of Calgary, Alberta, Canada.
J B
JB
Meddings
L R
LR
Sutherland
N I
NI
Byles
J L
JL
Wallace
D000818:Animals; D004378:Duodenal Diseases / Q000175:diagnosis / Q000378:metabolism*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D010539:Permeability; D011817:Rabbits; D013272:Stomach Diseases / Q000175:diagnosis / Q000378:metabolism*; D013393:Sucrase / Q000378:metabolism; D013395:Sucrose / Q000493:pharmacokinetics
D013395:Sucrose; D013393:Sucrase; D007213:Indomethacin