The role of the endocrine factors and obesity in hormone-dependent gynecological neoplasias.
Between September 1990 and February 1992, we studied 70 women of post-menopausal age, of whom 33 were affected by hormone-dependent gynecologic tumors and 37 by other pathologies, measuring estrogens, androgens, SHBG and also measuring excess fat and its distribution. The aim of our research was to ascertain what relation there was between adipose tissue, taking account central or peripheric localization, the levels of sex steroids and the onset of endometrial and breast cancer. In the group of tumor patients, we found a quantity of fat mass greater than in the control group (p < 0.05); there was, beside, in the first group, an inverse proportional correlation between the SHBG levels and BMI, and between SHBG and the fat mass (P < 0.05). We also observed an inverse relation between the levels of testosterone and SHBG (P < 0.05). These findings confirm the role that the adipose tissue and androgens would have on the globulin production, which in turn would reflect on the percentage of potentially active steroids in endometrial and mammary tissues. We also wished to ascertain if the distribution of fatty tissue (prevalently abdominal or prevalently gluteo-femoral) could have different endocrine-metabolic consequences. We found a directly proportional relation between an index of central obesity, the T/L Ratio, and the levels of DHA-S (P < 0.05), but the significance of this relation is not clear, inasmuch as DHA-S is one of the least active of the androgens.(ABSTRACT TRUNCATED AT 250 WORDS)
Maggino
T
T
Gynaecologic Obstetric Institute, University of Padua.
Pirrone
F
F
Velluti
F
F
Bucciante
G
G
D019326:17-alpha-Hydroxyprogesterone; D000273:Adipose Tissue / Q000502:physiology; D000368:Aged; D000728:Androgens / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight; D001943:Breast Neoplasms / Q000097:blood / Q000209:etiology*; D016889:Endometrial Neoplasms / Q000097:blood / Q000209:etiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D008593:Menopause; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D011753:Pyrones / Q000097:blood; D012044:Regression Analysis; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D000728:Androgens; D006728:Hormones; D006908:Hydroxyprogesterones; D011753:Pyrones; D012738:Sex Hormone-Binding Globulin; C027493:dehydroacetic acid; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone