[A comparison of the efficacy of the anticlastogenic action of interferon and of the radiation-adaptive response].
Human lymphocytes, in the in vitro culture, exposed to X-rays (0.05 Gy) or treated with lymphoblastoid interferon (50 IE/ml) in phase G1 were less susceptible to induction of chromosome aberrations, of a chromosome type, by subsequent gamma-radiation (2 Gy) than those exposed to 2 Gy radiation only. The anticlastogenic effect of the pretreatment with interferon was considerably higher than that of preirradiation with X-rays which might be the result of the pleiotropic action of interferon in a cell.
G P
GP
Makedonov
N I
NI
Alekhina
L V
LV
Tskhovrebova
G D
GD
Zasukhina
D000222:Adaptation, Physiological / Q000187:drug effects* / Q000528:radiation effects*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects
D016587:Antimutagenic Agents; D003037:Cobalt Radioisotopes; D016898:Interferon-alpha
Sravnenie éffektivnosti antiklastogennogo deĭstviia interferona i radioadaptivnogo otveta.