7S nerve growth factor has different biological activity from 2.5S nerve growth factor in vitro.
It is considered that two molecular forms of nerve growth factor (NGF), that is 7S NGF and 2.5S NGF have the identical neurotrophic effect on neurons. We now report that 7S NGF has different biological activities from 2.5S NGF in vitro. 7S NGF could promote the survival and neurite outgrowth of neurons from newborn rat hippocampus, cortex and cerebellum and stimulate the proliferation of astrocytes in vitro, but 2.5S NGF had no such effect.
Beijing Institute of Basic Medical Sciences, People's Republic of China.
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N
Shao
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H
Wang
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T
Zhou
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C
Liu
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000187:drug effects; D001921:Brain / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D008934:Mitogens / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013936:Thymidine / Q000378:metabolism
C081722:2.5S nerve growth factor; C488870:7S nerve growth factor protein, rat; D008934:Mitogens; D009414:Nerve Growth Factors; D004247:DNA; D013936:Thymidine