Efficacy of sweeteners and sugar substitutes in caries prevention.
The caries-preventive efficacy of sweeteners and sugar substitutes is not clearly established on an epidemiological scale. A review of cariogenicity assessments in vitro and in vivo as well as of human clinical caries trials, however, clearly demonstrates that the replacement of sugar by such products has a caries-preventive effect. The clinical relevance of some bacteriostatic and/or cariostatic properties ascribed to saccharin, aspartame, and xylitol remains to be corroborated.
Department of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Switzerland.
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D001218:Aspartame / Q000627:therapeutic use; D002327:Cariostatic Agents; D003494:Cyclamates / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D004187:Disaccharides / Q000627:therapeutic use; D006801:Humans; D008320:Maltose / Q000031:analogs & derivatives / Q000627:therapeutic use; D008353:Mannitol / Q000627:therapeutic use; D012439:Saccharin / Q000627:therapeutic use; D013012:Sorbitol / Q000627:therapeutic use; D013402:Sugar Alcohols / Q000627:therapeutic use; D013549:Sweetening Agents / Q000627:therapeutic use*; D014993:Xylitol / Q000627:therapeutic use*
D002327:Cariostatic Agents; D003494:Cyclamates; D004187:Disaccharides; D013402:Sugar Alcohols; D013549:Sweetening Agents; D008353:Mannitol; D013012:Sorbitol; C016640:Palatinit; D008320:Maltose; C014646:Lycasin; C010745:maltitol; D012439:Saccharin; C014635:lactitol; D014993:Xylitol; D001218:Aspartame