Tophaceous gout in patients with renal transplants treated with cyclosporine A.
Hyperuricemia and gout have been associated with cyclosporine A (CyA) therapy in transplant recipients. We describe 4 patients who developed severe tophaceous gout after renal transplantation. All of the patients received CyA, prednisone, and diuretic therapy. Three had episodes of allograft rejection. No patient had the diagnosis of gout before transplantation. All developed tophi within 5 years of the first attack of gout. Management of these patients has been difficult due to renal insufficiency, drug interactions and toxicity. Clinicians should be aware that tophaceous gout can occur rapidly in CyA treated transplant recipients.
Department of Medicine, Louisiana State University Medical Center in Shreveport.
B A
BA
Baethge
J
J
Work
M D
MD
Landreneau
J C
JC
McDonald
D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006073:Gout / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011859:Radiography; D014527:Uric Acid / Q000378:metabolism
D014527:Uric Acid; D016572:Cyclosporine