Initial hypoalbuminemia and hyperlipidemia persist during chronic peritoneal dialysis in children.
OBJECTIVE
To document serum lipid values in pediatric peritoneal dialysis (PD) patients, particularly the very young, and investigate relationships with serum albumin levels.


METHODS
Retrospective review of all PD patients seen in the first 11 years of the PD program at our institution.


METHODS
Any pediatric PD patient was eligible for inclusion if at least four simultaneous measurements of serum lipids and albumin were recorded over a minimum of 90 days of PD.


RESULTS
Thirty-nine continuous ambulatory peritoneal dialysis (CAPD) patients (9, aged < 5 years) and 14 continuous cycling peritoneal dialysis (CCPD) patients (7, aged < 5 years) were followed for 90-1200 days. Hypoalbuminemia, present in 43% of initial recordings, did not alter significantly during PD in any group; it was most marked in the CAPD < 5 year (mean 30.7 g/L) and CCPD > 5 year groups (mean 31.4 g/L). Average serum cholesterol levels were 27% higher, and triglyceride 122% higher, than the maximum accepted 18-year-old level and did not change significantly during PD. Similarly, 33% of high-density lipid recordings were below normal and remained unaltered during PD.


CONCLUSIONS
Our results confirm the high incidence of hypoalbuminemia, hypertriglyceridemia, and hypercholesterolemia and associated low levels of high-density lipids, even in young PD patients, and demonstrate that these remain unchanged during PD. Such results have not previously been reported in PD patients as young as ours. Abnormal lipid profiles are a neglected cardiovascular risk factor in children with renal failure; therapeutic interventions should therefore be seriously considered.
Division of Nephrology, Hospital for Sick Children, Toronto, Ontario, Canada.
D
D
Scolnik
J W
JW
Balfe
D001798:Blood Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology; D007223:Infant; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis*; D014280:Triglycerides / Q000097:blood
D001798:Blood Proteins; D008055:Lipids; D008075:Lipoproteins, HDL; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol