Effects of corticosteroids on bone turnover.
The pathophysiology of corticosteroid-induced osteoporosis is complex, but centres around a primary inhibition of osteoblastic activity compounded by the effects of secondary hyperparathyroidism. The preservation of the microanatomy of bone in the early stages of the disease, coupled with strategies to prevent the emergence of secondary hyperparathyroidism, and the potential availability of osteoblastic stimulants offer the hope of minimizing this important side-effect of corticosteroid therapy.
Hosking
D J
DJ
City Hospital, Nottingham, U.K.
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D010024:Osteoporosis / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D012739:Gonadal Steroid Hormones; D002118:Calcium