[Pulmonary antiprotease defense].
The pulmonary alveolar spaces are spatially organized in order to facilitate gaz exchanges. Proteases, responsible for the destruction of the connective tissue and for the disorganization of the alveolar structures, are present within the lung. Neutrophil elastase is the most important. Numerous antiproteases are present in the lung the most important being alpha-1-antitrypsin. Its blood level is diminished during an autosomal hereditary disease: alpha-1-antitrypsin deficiency. It can be corrected by infusion of purified alpha-1-anti-trypsin.
Laboratoire d'immunologie et de biologie pulmonaire, hôpital Louis-Pradel, BP Lyon-Montchat.
J F
JF
Mornex
D005260:Female; D006801:Humans; D008168:Lung / Q000201:enzymology*; D008297:Male; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin; D010196:Pancreatic Elastase
La défense antiprotéase pulmonaire.