Fine needle aspiration (FNA)-induced necrosis of tumours of the thyroid.
Two cases of necrosis of thyroid oxyphilic tumours following FNA are reported. The first patient received surgery 4 weeks after FNA and histological examination revealed an encapsulated and totally necrotic tumour 2 cm in diameter. In the second patient surgery was performed after 25 days. Histological examination showed a 0.7 cm diameter tumour consisting mainly of fibrous tissue with residual oxyphilic tumour cells only in a small peripheral rim. In both patients no capsular or vascular invasion and no blood vessel thrombosis were present. A review of the literature revealed that oxyphilic tumours are susceptible to post-FNA necrosis, which might be due to the compromised vascular supply after FNA in conjunction with the intrinsic energy deficiency of oncocytic tumour cells.
Institute of Pathology, University Hospital, Düsseldorf, Germany.
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U
Ramp
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Pfitzer
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HE
Gabbert
D018249:Adenoma, Oxyphilic / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001707:Biopsy, Needle / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery