Ciprofloxacin for treatment of severe typhoid fever in children.
Eighteen children with bacteriologically confirmed severe typhoid fever were initially treated intravenously with ciprofloxacin (10 mg/kg of body weight per day). Clinical cure with eradication of multiresistant Salmonella typhi infection was observed in 17 patients (94.4%; 95% confidence interval [CI], 84 to 100%). Children regained normal consciousness within an average of 2 days (95% CI, 1.8 to 2.2 days). The temperatures of the children returned to normal within 3.3 days (95% CI, 3.1 to 3.5 days). Complications were not observed during the hospital stay or a 3-month follow-up period. Relapse and carrier state were also not encountered during the follow-up period.
Dutta
P
P
National Institute of Cholera and Enteric Diseases, Calcutta, India.
Rasaily
R
R
Saha
M R
MR
Mitra
U
U
Bhattacharya
S K
SK
Bhattacharya
M K
MK
Lahiri
M
M
D001831:Body Temperature; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D016638:Critical Illness; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D012008:Recurrence; D014435:Typhoid Fever / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
D002939:Ciprofloxacin