Fluorescence in situ hybridization and cytogenetics of hemopoietic malignancies: new developments.
Fluorescence in situ hybridization (FISH) is currently developed to analyse chromosomal abnormalities of hemopoietic malignancies in several ways: description of chromosomal rearrangements using specific probes or chromosome painting; delineation of chromosomal breakpoints with probes previously localized to chromosomal bands; hybridization to interphase nuclei to detect numerical changes and, now, some structural abnormalities. Examples of usefulness of FISH to study hemopoietic malignancies are given.
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Unité INSERM U, CNRS, Institut de Génétique Moléculaire, Paris, France.
Berger
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D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic