Loss of the 'azoospermia factor' (AZF) on Yq in man is not associated with loss of HYA.
We have typed 9 EBV cell lines from azoospermic or severely oligospermic patients for the expression of H-Y antigen, in order to test the hypothesis of the coincidence of AZF and HYA genes. Of nine patients with cytogenetically normal Y chromosomes, 7 could be tested for HYA expression and of these 6 were H-Y positive. Of the three patients showing Yq structural abnormalities, two could be tested for H-Y expression and one was negative, the other positive. These results therefore show no correlation between spermatogenic failure and the absence of HYA, thus separating the AZF locus from HYA.
Clinical Research Centre, Harrow, Middlesex, UK.
E
E
Simpson
P
P
Chandler
E
E
Goulmy
K
K
Ma
T B
TB
Hargreave
A C
AC
Chandley
D000328:Adult; D002460:Cell Line; D002869:Chromosome Aberrations; D017353:Gene Deletion; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D014998:Y Chromosome
D006182:H-Y Antigen