Is there a need for long-term thromboprophylaxis following general surgery?
Thromboprophylaxis to surgical patients is generally accepted, and used in the perioperative period by many surgeons as effective means of reducing postoperative thromboembolic complications. Often the prophylaxis is stopped at the time of mobilization or discharge of the patient, although late thromboembolic complications after cessation of the postoperative prophylaxis are known to occur up to 7 weeks after surgery. By scrutinizing thromboprophylactic studies performed in general surgery during the last 20 years, we found the incidence of late thromboembolic complications reported to be about 1% when clinical diagnostics was applied. In studies where the patients were screened for late thromboembolic complications using paraclinical diagnostic methods the incidence is 10 times higher. The clinical relevance of these late postoperative thromboembolic complications is still uncertain, as is the value of long-term prophylaxis.
Department of Surgical Gastroenterology K, Bispebjerg Hospital, University of Copenhagen, Denmark.
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Wille-Jørgensen
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Lausen
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Jørgensen
D001458:Bandages; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D015994:Incidence; D008403:Mass Screening; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000453:epidemiology / Q000517:prevention & control*; D013997:Time Factors; D000078222:Tinzaparin
D006495:Heparin, Low-Molecular-Weight; D000078222:Tinzaparin; D006493:Heparin