HLA A/B recombination in a white woman with the S-s-phenotype of the MNS system.
In cases of disputed parentage, the possibility of simultaneous occurrence of rare events in the population must be considered. PURPOSE--To report a case in which HLA-A/B recombination and homozygosity of a silent allele, typical of Negroes, in an individual apparently without this miscegenation were coexistent. METHODS--Alleged father, mother and dizygotic twin children were racially classified according to their apparent somatic characters. Blood group genetic markers of ABO, Rh, MNS, Kell, Duffy, HLA-A, -B systems were phenotyped; mother's HLA genotyping was performed by her parents test. RESULTS--The phenotype of the White mother, in the MNS system, was M+; N-; S-; s-. Alleged father and both twins were phenotipically compatible. The assumed maternity relating to both children was possible if mother presented an HLA-A/B recombination. CONCLUSION--In miscegenated populations, the breakup between ethnical appearance and blood group markers is foreseeable. Allele/haplotypic frequencies of these populations should be estimated. Casuistically, the association of events with low frequency in the population can be the cause of apparent exclusions of parentage.
Instituto de Medicina Social e Criminologia de São Paulo.
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Salaru
D000483:Alleles; D005260:Female; D005819:Genetic Markers; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics; D010334:Paternity; D010641:Phenotype; D011995:Recombination, Genetic
D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D008951:MNSs Blood-Group System