Effects of subinhibitory concentrations of vancomycin and teicoplanin on adherence of staphylococci to tissue culture plates.
Bacterial adhesion is the first step in infection of medical devices. Staphylococcus aureus and Staphylococcus epidermidis are the pathogens recovered most often. The effects of subinhibitory concentrations of vancomycin and teicoplanin on the adherence of eight clinical strains of S. aureus and eight strains of S. epidermidis to tissue culture plates in vitro were tested. The mean relative inhibitions of adherence at one-fourth and one-eighth the MIC were statistically different for teicoplanin and vancomycin. Slime production seemed not to be involved in adherence.
Infectious Disease Department, Archet Hospital, Nice, France.
H
H
Carsenti-Etesse
J
J
Durant
J
J
Entenza
V
V
Mondain
C
C
Pradier
E
E
Bernard
P
P
Dellamonica
D001422:Bacterial Adhesion / Q000187:drug effects*; D015169:Colony Count, Microbial; D003470:Culture Media; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
D003470:Culture Media; D017334:Teicoplanin; D014640:Vancomycin