Experiments on maternal and paternal transmission of Creutzfeldt-Jakob disease in mice.
No transmission of Creutzfeldt-Jakob disease in mice was observed in 75 offspring born to CJD agent-inoculated females or to normal females mated with inoculated males and in 19 normal offspring maintained by foster nursing with the inoculated mothers. The fertility of young adult female mice was lost by the 57th day after the inoculation, whereas the reproductivity of male mice was maintained over 106 days after the inoculation.
Department of Microbiology, School of Hygienic Sciences, Kitasato University, Kanagawa, Japan.
F
F
Taguchi
Y
Y
Tamai
S
S
Miura
D000375:Aging; D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000503:physiopathology / Q000635:transmission*; D005260:Female; D005298:Fertility; D008098:Litter Size; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011328:Prions / Q000472:pathogenicity*; D012737:Sex Factors
D011328:Prions