Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate.
Prashad
M
M
Sandoz Research Institute, East Hanover, New Jersey 07936.
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002412:Cations; D005204:Farnesol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D013185:Squalene / Q000378:metabolism
D000578:Amidines; D002412:Cations; C081343:N-homogeranyl-N-methyl-N'-farnesylformamidine; D005204:Farnesol; D013185:Squalene; D013186:Farnesyl-Diphosphate Farnesyltransferase