Synthesis of beta-hematin by dehydrohalogenation of hemin.
beta-Hematin, the metalloporphyrin coordination polymer present in malaria pigment, is prepared in high yield by the abstraction of HCl from hemin with a non-coordinating base in strictly anhydrous conditions. The product of this preparation is characterized by elemental analysis, infrared and diffuse reflectance spectroscopies and demonstrated to be identical to prior preparations.
Department of Chemistry, University of Wyoming, Laramie 82071-3838.
D S
DS
Bohle
J B
JB
Helms
D000818:Animals; D002417:Cattle; D006427:Hemin / Q000737:chemistry*; D007202:Indicators and Reagents; D013053:Spectrophotometry
D007202:Indicators and Reagents; D006427:Hemin