Emetic responses of Sorex unguiculatus.
We have shown previously that Suncus murinus, a species of the insectivore, can vomit in response to various emetogenic stimuli. In the present study we investigated whether or not Sorex unguiculatus, which belongs to different subfamily (Soricinae) of insectivore, vomits in response to emetogenic drugs. Subcutaneous injection of veratrine and oral administration of copper sulfate caused emesis in the animal. Histological study showed that bilateral structure of the area postrema was not important for the emetic reflex. Therefore, the capability of emesis may be common to the family of soricidae of the insectivore, and the Sorex unguiculatus is the smallest known mammal which can vomit.
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
N
N
Matsuki
Y
Y
Torii
T
T
Kaji
N
N
Nishiyama
J
J
Ishiyama
N
N
Chida
H
H
Saito
D000818:Animals; D003300:Copper; D019327:Copper Sulfate; D007312:Eulipotyphla / Q000502:physiology*; D008636:Mesencephalon / Q000648:ultrastructure; D012018:Reflex; D014702:Veratrine; D014839:Vomiting / Q000139:chemically induced*
D003300:Copper; D014702:Veratrine; D019327:Copper Sulfate