Effects of nitroglycerin on hemodynamics in dogs with experimentally inserted heartworms.
Hemodynamic effects of nitroglycerin were investigated in dogs with right ventricular failure including engorgement of the pulmonary artery and ascites induced by insertion of adult live heartworms into the pulmonary artery. The mean pulmonary arterial pressure (21.5 +/- 6.6 mmHg) in heartworm-inserted dogs 4 or 5 weeks after heartworm insertion were higher than that of control (4.2-7.1 mmHg). Nitroglycerin administered intravenously at doses of 3 or 10 micrograms/kg decreased pulmonary arterial pressure in these heartworm inserted dogs. This drug also decreased pulmonary vascular resistance and total systemic resistance with no effect on cardiac index and heart rate.
Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Japan.
S
S
Yamamoto
K
K
Miyatake
Y
Y
Okamoto
S
S
Minami
A
A
Matsuhashi
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004184:Dirofilariasis / Q000503:physiopathology*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000469:parasitology; D011652:Pulmonary Circulation / Q000187:drug effects; D012016:Reference Values; D014655:Vascular Resistance / Q000187:drug effects; D016278:Ventricular Function, Right / Q000187:drug effects
D005996:Nitroglycerin