Septo-optic dysplasia associated with polyendocrine dysfunction.
Septo-optic dysplasia (SOD) is a rare congenital disease that has been described in association with hypothalamic dysfunction. A case of polyendocrine dysfunction is described in a 22 year-old white female with septo-optic dysplasia. Findings included atrophic optic nerves, a cavum septum pellucidum and a small pituitary gland detected by magnetic resonance imaging. The patient had central diabetes insipidus, Hashimoto's thyroiditis, and gestational diabetes mellitus. A review of the literature is presented. A careful and detailed endocrine evaluation is needed in patients with SOD.
Department of Medicine, University of Rochester Medical Center, NY 14642.
N W
NW
Shammas
J D
JD
Brown
B W
BW
Foreman
D R
DR
Marutani
D
D
Maddela
D
D
Tonner
D000328:Adult; D003919:Diabetes Insipidus / Q000150:complications*; D016640:Diabetes, Gestational / Q000150:complications*; D005260:Female; D006801:Humans; D009900:Optic Nerve / Q000002:abnormalities*; D011247:Pregnancy; D012688:Septum Pellucidum / Q000002:abnormalities*; D013967:Thyroiditis, Autoimmune / Q000150:complications*