Influence of therapeutic plasmapheresis on elimination of ceftiaxone.
To study the plasma elimination rate of ceftriaxone given to patients undergoing plasmapheresis, a single 2-g intravenous dose of ceftriaxone was given to 11 patients who underwent plasmapheresis 3 h (early group) or 15 h (late group) later. Even though the early patient group had twofold more ceftriaxone removed than the late group, all individual patients had 24-h ceftriaxone levels of 9 micrograms/ml or higher. We conclude that patients undergoing plasmapheresis lasting 150 min or less may safely be treated with 2 g of ceftriaxone once daily without risking periods of subtherapeutic plasma ceftriaxone levels.
Bakken
J S
JS
Duluth Clinic, Ltd., Minnesota.
Cavalieri
S J
SJ
Gangeness
D
D
Kubat
T
T
Pollack
J R
JR
D000328:Adult; D000368:Aged; D002443:Ceftriaxone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004058:Diffusion; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis
D002443:Ceftriaxone