The treatment of neonatal meningitis due to gram-negative bacilli with ciprofloxacin: evidence of satisfactory penetration into the cerebrospinal fluid.
We describe two cases of neonatal meningitis due to Gram-negative bacilli treated successfully with ciprofloxacin. Examination of serial samples of cerebrospinal fluid indicated the effect of meningeal inflammation on penetration of this drug into the CSF.
Green
S D
SD
Department of Paediatrics, Institut Médical Evangélique, Kimpese, Zaïre.
Ilunga
F
F
Cheesbrough
J S
JS
Tillotson
G S
GS
Hichens
M
M
Felmingham
D
D
D002939:Ciprofloxacin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D005417:Flavobacterium / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D002939:Ciprofloxacin