"Stiff red cell syndrome". A review of the treatment of sickle cell disease with pentoxifylline.
Pentoxifylline has been used extensively to improve microcirculation, particularly in peripheral vascular disease. Pentoxifylline appears to act by increasing red cell flexibility and inhibiting platelet aggregation and white cell adhesion. For that reason, experimental and clinical studies were initiated to explore its possible usefulness in the prevention of vaso-occlusive crises in sickle cell diseases. The current status of such studies is reviewed.
State University of New York, Department of Internal Medicine, Buffalo General Hospital 14203.
J L
JL
Ambrus
T M
TM
Reddington
N N
NN
Meky
J
J
Conway
D000818:Animals; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D008251:Macaca; D008833:Microcirculation; D010431:Pentoxifylline / Q000494:pharmacology / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D012805:Sickle Cell Trait / Q000097:blood / Q000150:complications*; D014652:Vascular Diseases / Q000209:etiology / Q000517:prevention & control*
D010975:Platelet Aggregation Inhibitors; D010431:Pentoxifylline