A study of the electrochemical oxidation of Navelbine.
The search for drugs with cytostatic activity and with better pharmacokinetic features led to the synthesis of Navelbine (5'-noranhydrovinblastine) which is a structural modification of antitumour Vinca alkaloids. The new drug Navelbine has high liposolubility, a lower toxicity and increased antitumour activity. The electrochemical oxidation of Navelbine was studied over a wide pH range (1.2-12.8) at a glassy carbon disc electrode in buffered aqueous media using differential pulse and cyclic voltammetry. The anodic oxidation mechanism is a very complex, pH dependent, multistep electron transfer process with coupled homogeneous chemical reactions.
Departamento de Química, Universidade de Coimbra, Portugal.
A M
AM
Brett
M M
MM
Grazina
T R
TR
Macedo
C
C
Oliveira
D
D
Raimundo
D000970:Antineoplastic Agents / Q000737:chemistry*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000737:chemistry; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D014747:Vinblastine; D000077235:Vinorelbine