Abl tyrosine protein kinase.
Mammalian c-Abl belongs to an evolutionary conserved family of non-receptor tyrosine kinases. It is distributed both in the cytoplasm in association with F-actin, and in the nucleus where it binds chromatin. The normal function of c-Abl is poorly understood. Nevertheless, there has been rapid progress in the characterization of the structural features, signal transduction pathways, substrates and ligands involved in the action of c-Abl and Abl-derived oncogenes. These developments suggest that several mechanisms co-operate to allow regulation of normal cell growth by c-Abl and induction of leukemias by Bcr-abl.
Department of Medicine, McGill University, Montreal, Canada.
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Laneuville
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases; D016315:Proto-Oncogene Proteins c-abl
D011505:Protein-Tyrosine Kinases; D016315:Proto-Oncogene Proteins c-abl