Acute hemodynamic effects of digitalis.
The available data suggest that acute administration of digoxin improves rest and exercise hemodynamics in patients in sinus rhythm or in atrial fibrillation who manifest a low cardiac output and increased left ventricular end-diastolic pressure that is due to systolic dysfunction. It appears that these acute beneficial effects are maintained during chronic digoxin therapy. The hemodynamic effects of digoxin in patients with isolated diastolic dysfunction and abnormal hemodynamics remain to be investigated.
Northwestern University Medical School, Department of Medicine, Chicago, Ill.
J
J
Tauke
M
M
Gheorghiade
D000818:Animals; D002303:Cardiac Output, Low / Q000188:drug therapy; D004071:Digitalis Glycosides / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy*
D004071:Digitalis Glycosides