Restriction to a limited set of EEG-target variables may lead to misinterpretation of pharmaco-EEG results.
The number and types of target variables quantified from the spectrally analyzed EEG used in topographic pharmaco-EEG studies are still being discussed. Drug-induced changes of target variables obtained in the alpha frequency band--four absolute and four relative powers as well as three frequency measures--were utilized to assess the effects of xantinolnicotinate in demented patients using a parallel group design and the effects of buspirone in a double-blind, placebo-controlled crossover design. We conclude that for the proper evaluation of the different drug effects on the alpha activity, all these target variables should be considered. Descriptive p values of multiple comparisons within the framework of descriptive data analyses are important tools in interpreting drug effects.
Department of Psychiatry, University of Vienna, Austria.
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P
Anderer
M J
MJ
Barbanoj
B
B
Saletu
H V
HV
Semlitsch
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002065:Buspirone / Q000494:pharmacology; D003704:Dementia / Q000188:drug therapy / Q000503:physiopathology; D003975:Diazepam / Q000494:pharmacology; D004311:Double-Blind Method; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D013997:Time Factors; D014971:Xanthinol Niacinate / Q000494:pharmacology
D014971:Xanthinol Niacinate; D003975:Diazepam; D002065:Buspirone