[Analysis of breath hydrogen (H2) in diagnosis of gastrointestinal function: validation of a pocket breath H2 test analyzer].
Breath hydrogen (H2) analysis, as used in gastroenterologic function tests, requires a stationary analysis system equipped with a gaschromatograph or an electrochemical sensor cell. Now a portable breath H2-analyzer has been miniaturized to pocket size (104 mm x 62 mm x 29 mm). The application of this device in clinical practice has been assessed in comparison to the standard GMI-exhaled monitor. The pocket analyzer showed a linear response to standards with H2-concentrations ranging from 0-100 ppm (n = 7), which was not different from the GMI-apparatus. The correlation of both methods during clinical application (lactose tolerance tests, mouth-to-coecum transit time determined with lactulose) was excellent (Y = 1.08 X + 0.96; r = 0.959). Using the new device, both, analysis (3 s vs. 90 s) and the reset-time (43 s vs. 140 s) were shorter whereas calibration was more feasible with the GMI-apparatus. It is concluded, that the considerably cheaper pocket-sized breath H2-analyzer is as precise and sensitive as the GMI-exhaled monitor, and thus presents a valid alternative for H2-breath tests.
Abt. für Gastroenterologie, Universitätskliniken Frankfurt am Main.
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Braden
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Braden
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Klutz
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Lembcke
D001944:Breath Tests / Q000295:instrumentation*; D004867:Equipment Design; D005950:Glucose Solution, Hypertonic; D006801:Humans; D006859:Hydrogen / Q000032:analysis*; D007787:Lactose Intolerance / Q000175:diagnosis*; D007792:Lactulose; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
D005950:Glucose Solution, Hypertonic; D007792:Lactulose; D006859:Hydrogen
Wasserstoff-(H2)-Atemgasanalytik in der gastroenterologischen Funktionsdiagnostik: Validierung eines Pocket-H2-Atemtestgerätes.