Characterization of Reed-Sternberg cells with granulocyte specific monoclonal antibody.
Monoclonal antibody Leu M1 represents a highly specific marker to locate granulocyte antigen in Reed-Sternberg cells in Hodgkin's disease. Except the L&H variants of reed-sternberg cells in lymphocyte predominance variety in which antigens are probably sialylated. All the cases of non-Hodgkin's lymphoma were negative with this marker, because of absence of antigen. Therefore this specific marker characterizes granulocyte origin of reed-sternberg cells.
Memon
G M
GM
Department of Pathology, Jinnah Postgraduate Medical Centre, Karachi.
Alam
S M
SM
D000911:Antibodies, Monoclonal; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D016539:Reed-Sternberg Cells / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015214:Antigens, Differentiation, Myelomonocytic