Pharmacokinetics of single-dose administration of naproxen at 10:00 and 22:00 hours.
The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations.
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
B R
BR
Rao
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Rambhau
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Rao
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D009288:Naproxen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D009288:Naproxen