Current concepts in DRA gene regulation.
The purpose of this review is to provide an interpretative view of work from our laboratory on the DRA gene, and incorporate it with work from other laboratories. Specially, we will deal with: (a) the functional roles of transcription factors in DRA gene regulation; (b) the mechanisms of DRA induction by cytokines; (c) the analysis of DRA gene control in primary untransformed cells, and (d) interactions among transcription factors critical for DRA gene expression.
Department of Microbiology-Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295.
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D001483:Base Sequence; D002460:Cell Line; D016207:Cytokines / Q000502:physiology; D005786:Gene Expression Regulation; D006684:HLA-DR Antigens / Q000096:biosynthesis / Q000235:genetics*; D059805:HLA-DR alpha-Chains; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011485:Protein Binding; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology
D016207:Cytokines; D006684:HLA-DR Antigens; D059805:HLA-DR alpha-Chains; D014157:Transcription Factors