Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.
Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of benastatin C was elucidated as 2-decarboxy-benastatin A by NMR studies. Benastatin D, 2-decarboxybenastatin B, was derived from benastatin B. Benastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST pi) and excellent stimulatory activities on the murine lymphocyte blastogenesis in vitro.
Aoyama
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Kojima
F
F
Yamazaki
T
T
Tatee
T
T
Abe
F
F
Muraoka
Y
Y
Naganawa
H
H
Aoyagi
T
T
Takeuchi
T
T
D000818:Animals; D001551:Benz(a)Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009279:Naphthacenes; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001551:Benz(a)Anthracenes; D009279:Naphthacenes; C081736:benastatin C; C081737:benastatin D; D005982:Glutathione Transferase