Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma.
It has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.
Department of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, UK.
M H
MH
Goyns
D W
DW
Hammond
C J
CJ
Harrison
L P
LP
Menasce
F M
FM
Ross
B W
BW
Hancock
D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D008297:Male; D014960:X Chromosome / Q000648:ultrastructure*