A three compartment open model with two time lags.
The present study deals with the identification of exchange parameters involved in a three-compartment open model with two time lags in which elimination occurs from the central compartment. Two different optimization methods have been used which involve the reduction of different unknowns to a single variable theta, with the help of Archimedes Spiral. Thus, the solution requires the global minimum of a functional of single variable theta. Results are compared with those obtained by the generalized least square method.
Cherruault
Y
Y
Medimat, Universite Paris VI, France.
Sarin
V B
VB
D000042:Absorption; D000465:Algorithms; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D013997:Time Factors
D004364:Pharmaceutical Preparations