Mechanisms and management of septic shock.
Septic shock continues to be associated with high mortality. The systemic effects of severe infections are related to the release and activation of a myriad of mediator systems, central to which are bacterial toxins and cytokines. Therapy includes three facets--resuscitation, treatment of the underlying infection, and interventions directed at ameliorating mediator activity.
Rackow
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Department of Medicine, St. Vincent's Hospital and Medical Center, New York, New York.
Astiz
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ME
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003422:Critical Care; D004734:Energy Metabolism; D006439:Hemodynamics; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood / Q000378:metabolism; D010101:Oxygen Consumption; D012151:Resuscitation; D012772:Shock, Septic / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D015996:Survival Rate
D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D007773:Lactates; D019344:Lactic Acid; D010100:Oxygen