Enhancement of anti-inflammatory activity of aspirin by verapamil.
Verapamil in minimum therapeutic equivalent dose, failed to show anti-inflammatory activity as did sub-anti-inflammatory dose of aspirin (54 mg/kg) however, when combined with sub-antiinflammatory dose of aspirin, significant (P < 0.001) inhibition of carrageenan and cotton pellet induced inflammation was observed. The anti-inflammatory activity of this combination treatment was almost comparable to that of the anti-inflammatory dose of aspirin (200 mg/kg), as confirmed by granuloma histology. Adrenal weight in the combination treatment group was similar to that of aspirin (200 mg) treated group and was significantly lower, as compared to controls. Further, a reduced ulcer index in the animals treated with combination (aspirin + verapamil), as compared to aspirin alone (200 mg) group, suggests its therapeutic potential.
Viswanadham
C K
CK
Department of Pharmacology, KLE Society's College of Pharmacy, J.N. Medical College, Belgaum.
Patil
P A
PA
D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan / Q000037:antagonists & inhibitors; D004357:Drug Synergism; D005260:Female; D005547:Foreign Bodies; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control; D013810:Therapeutic Equivalency; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D002351:Carrageenan; D014700:Verapamil; D001241:Aspirin