The effects of hexane on rat myocardium: a morphometric and morphological study.
Specimens from the left ventricular myocardium of 10 rats that had been exposed to subcutaneously administered hexane for 30 days were morphometrically and morphologically examined. Other than the presence of occasional necrotic fibres in hexane-treated animals, there was little difference in the histological appearance of myofibres in control or experimental specimens. There was a slight reduction in the average diameter of cardiac myofibres after exposure to hexane. Pathological ultrastructural changes of the myofibres were noted in the experimental and not in the control groups. Mitochondrial oedema and necrosis and myofilament disorganization and dissolution were significant changes noted in the experimental group. These pathological changes suggest that hexane, a constituent of glue and benzine, is cardiotoxic.
Maharaj
B
B
Department of Experimental Pharmacology, Medical School, University of Natal, Durban, South Africa.
Khedun
S M
SM
Gregory
M A
MA
Naicker
T
T
D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000818:Animals; D006321:Heart / Q000187:drug effects*; D006586:Hexanes / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D008933:Mitochondrial Swelling; D009206:Myocardium / Q000648:ultrastructure; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar
D006586:Hexanes; C026385:n-hexane