Impact of intrauterine exposure to phencyclidine (PCP) and cocaine on neonates.
A total of 505 newborns who were exposed to illicit drugs during intrauterine life were studied to investigate the prevalence, growth parameters, newborn manifestations, and other effects of intrauterine exposure to cocaine and phencyclidine (PCP). The results support the hypotheses that both drugs have serious effects on growth parameters, but this effect was much more pronounced in the cocaine group than in the PCP group. Furthermore, the incidence of borderline microcephalic infants (head circumferences less than the 10th percentile) was much higher in the cocaine group. It also appears that the signs and symptoms observed in both groups are not withdrawal manifestations typically seen in narcotic-exposed infants; rather, these symptoms are true drug effects and should not be considered manifestations of drug withdrawal symptoms.
Department of Pediatrics, Howard University Hospital College of Medicine, Washington, D.C. 20060.
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Rahbar
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Fomufod
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White
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Westney
D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008831:Microcephaly / Q000209:etiology; D009357:Neonatal Abstinence Syndrome / Q000209:etiology; D010622:Phencyclidine / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D003042:Cocaine; D010622:Phencyclidine