Peptide antigen presentation by non-classical MHC class I molecules.
The mouse major histocompatibility complex contains more than 40 class I genes in addition to those encoding the classical class I molecules. Many of these encode functional class I heavy chains that are expressed and displayed on the cell surface in association with beta 2-microglobulin. Several laboratories, using genetic, biochemical, and molecular analysis, RMA-S mutant cells, and synthetic peptides, have recently shown that mouse non-classical or class Ib molecules present peptide antigens to T lymphocytes with alpha beta or gamma delta receptors. The class Ib genes, with their limited polymorphism, may have evolved to serve specialized presentation functions.
Fischer Lindahl
K
K
Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235-9050.
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; D008562:Membrane Glycoproteins; D010455:Peptides; C032907:Q surface antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta; C028388:thymus-leukemia antigens