Pradimicins T1 and T2, new antifungal antibiotics produced by an actinomycete. I. Taxonomy, production, isolation, physico-chemical and biological properties.
Pradimicins T1 and T2, new members of the pradimicin family of antibiotics, were produced by an actinomycete strain AA3798. Pradimicin T1 exhibited potent activity against a wide spectrum of fungi in vitro and demonstrated efficacy against systemic Candida albicans and Aspergillus fumigatus infections in mice.
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
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Furumai
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Hasegawa
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Kakushima
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K
Suzuki
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Yamamoto
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Yamamoto
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Hirano
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Oki
D000191:Actinomycetaceae / Q000737:chemistry*; D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D005285:Fermentation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D000095643:Pradimicins and Benanomicins
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C081413:pradimicin T1; D000095643:Pradimicins and Benanomicins; C081414:pradimicin T2