Decreased platelet aggregation during pregnancy correlates with gestational age.
In vivo platelet aggregation was determined in pregnant women at different gestational ages and nonpregnant women by a modification of a method. A higher platelet count ratio (PCR) was found in pregnant women after a gestational age of 13 weeks. At 16-30 and 31-41 weeks of gestation, in vivo platelet aggregation was significantly decreased. The PCR, meaning the ratio of non-aggregated platelets to all circulating platelets, correlated significantly with gestational age. It is suggested that the decrease in in vivo aggregation measured during pregnancy reflects a summarized effect of different factors during pregnancy connected to placenta and uteroplacental vessels.
Kovács
A G
AG
Department of Obstetrics and Gynecology, Hollós József Hospital, Kecskemét, Hungary.
Makáry
A
A
Petö
J
J
Steinmetz
G
G
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D010974:Platelet Aggregation; D010976:Platelet Count; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third