Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi.
Six sesquiterpene-derived compounds, 1-6, which we call sollasins a-f, have been isolated from a deep water specimen of the sponge Poecillastra sollasi. The structures were elucidated by comparison of spectral data to related metabolites and confirmed using spectroscopic methods. The compounds inhibit the growth of the pathogenic fungi Candida albicans and Cryptococcus neoformans and the P-388 and A-549 tumor cell lines. Compounds 3 and 4 show weak inhibition of binding of [125I] angiotensin II to rat aorta smooth muscle cell membranes.
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Ft. Pierce, Florida 34946.
K B
KB
Killday
R
R
Longley
P J
PJ
McCarthy
S A
SA
Pomponi
A E
AE
Wright
R F
RF
Neale
M A
MA
Sills
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003455:Cryptococcus neoformans / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000378:metabolism; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011945:Receptors, Angiotensin; D012717:Sesquiterpenes; D000804:Angiotensin II