[The present status of nitrates in the treatment of ischemic heart disease].
The authors describe the development of nitrates from substances of the first generation (nitroglycerin and isosorbit dinitrate) to the second generation (isosorbit-5-mononitrate). They explain the mechanism of their action, haemodynamic effects and the problem of nitrate tolerance. Indications of their rational use are given.
I. interní klinika FN u sv. Anny, Brno.
M
M
Stejfa
J
J
Vítovec
D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009566:Nitrates / Q000494:pharmacology / Q000627:therapeutic use*
D009566:Nitrates
Soucasné postavení nitrátů v lécbĕ ischemické choroby srdecní.