Multiple self-healing squamous epitheliomata (ESS1) mapped to chromosome 9q22-q31 in families with common ancestry.
A gene (ESS1) predisposing to the development of multiple invasive but self-healing skin tumours (squamous cell epitheliomata) is tightly linked to the polymorphic DNA marker D9S53 (9q31) with a maximum lod score of 9.02 at a recombination fraction of 0.03. Multipoint linkage analysis demonstrates that the disease locus is most likely to lie between D9S58 (9q22.3-31) and ASSP3 (9q11-q22). Comparison of markers associated with ESS1 in independently ascertained families suggests a common origin of the disease and defines the location of ESS1. Haplotype studies indicate that the disease locus is most likely to lie between D9S29 (9q31) and D9S1 (9q22.1-q22.2).
Genetic and Tumour Virus, Pathology Unit, Cambridge University, UK.
D R
DR
Goudie
M A
MA
Yuille
M A
MA
Leversha
R A
RA
Furlong
N P
NP
Carter
M J
MJ
Lush
N A
NA
Affara
M A
MA
Ferguson-Smith
D000483:Alleles; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008969:Molecular Sequence Data; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics*; D009857:Oncogenes; D010375:Pedigree; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000235:genetics*
D015342:DNA Probes; D005819:Genetic Markers; D004247:DNA