Systemic histiocytosis presenting as multiple sclerosis.
A patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non-Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892.
M E
ME
Smith
D A
DA
Katz
J O
JO
Harris
J A
JA
Frank
C V
CV
Kufta
D E
DE
McFarlin
D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006644:Histiocytes / Q000473:pathology; D015614:Histiocytosis / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D011859:Radiography; D011877:Radionuclide Imaging
D005904:Glial Fibrillary Acidic Protein