Dialysis-associated amyloidosis.
Dialysis arthropathy (DA) and carpal tunnel syndrome are debilitating complications caused by dialysis-associated amyloidosis. They arise after several years of hemodialysis with cuprophane and their onset can be delayed with the use of high-flux dialysis. Serum C-reactive protein is elevated in patients with dialysis arthropathy, indicative of inflammatory processes. X-rays show periarticular bone cysts and erosive spondyloarthropathy. High-flux dialysis improves DA, but transplantation remains the best treatment.
Charing Cross and Westminster Medical School, London, UK.
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D000686:Amyloidosis / Q000209:etiology*; D002349:Carpal Tunnel Syndrome / Q000209:etiology*; D002482:Cellulose / Q000031:analogs & derivatives; D006801:Humans; D007592:Joint Diseases / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000628:therapy; D008567:Membranes, Artificial; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D006435:Renal Dialysis / Q000009:adverse effects*; D001613:beta 2-Microglobulin
D008567:Membranes, Artificial; D001613:beta 2-Microglobulin; D002482:Cellulose; C009865:cuprammonium cellulose