Photodynamic therapy for nasal and aural squamous cell carcinoma in cats.
Eighteen random-bred cats with a total of 19 nasal or aural squamous cell carcinomas were treated with photodynamic therapy, using aluminum phthalocyanine tetrasulfonate as the photosensitizer. Cats were irradiated at power densities of 100 mW/cm2 and energy densities of 100 J/cm2. Successful outcome was obtained in 10 tumors after 1 treatment, and 2 more tumors had complete responses after 1 or 2 additional treatments. Treatments were more effective in tumors of stage T2 or earlier. Five tumors had partial responses, and the response of 2 tumors could not be evaluated. The treatment was safe and well tolerated by most cats, although we found that cats should be kept out of sunlight for 2 weeks after treatment.
Peaston
A E
AE
Veterinary Medical Teaching Hospital, Davis, CA 95616.
Leach
M W
MW
Higgins
R J
RJ
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004428:Ear Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D004431:Ear, External; D005260:Female; D007211:Indoles / Q000627:therapeutic use; D008297:Male; D009669:Nose Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D009942:Organometallic Compounds / Q000627:therapeutic use; D010778:Photochemotherapy / Q000009:adverse effects / Q000662:veterinary*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome
D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C048577:aluminum tetrasulfophthalocyanine