Chronic treatment with valproate decreases the hypothermic response to clonidine.
Treatment with lithium (the prototype of an antimanic agent) attenuates responsiveness to the alpha 2-agonist clonidine in animal models. Valproate is now used to treat mania. The effect of treatment with this drug on responses mediated by an alpha 2-agonist have yet to be reported. The authors assessed the effect of a 14-day course of orally administered valproate on the rat's hypothermic response to clonidine. Treatment with valproate decreased this response.
Department of Psychiatry and Behavioral Sciences, University of Texas, Houston 77021.
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Dilsaver
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Minkus
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Swann
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003000:Clonidine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014635:Valproic Acid / Q000097:blood / Q000494:pharmacology*
D014635:Valproic Acid; D003000:Clonidine