Male antifertility compounds from Tripterygium wilfordii Hook f.
Extracts of the Chinese medicinal plant, Tripterygium wilfordii, cause reversible infertility in male animals. Sub-fractionation studies have now revealed that the plant extracts contain a number of compounds which are potent antifertility agents in male mammals, including the diterpenes triptolide and tripdiolide and an isomer of the latter. A triptolide, 12,13-chlorohydrin, which is a transformation product formed reversibly by interaction of triptolide with HCl, was also found to be active.
Matlin
S A
SA
Chemistry Dept., City University, Northampton Square, London, UK.
Belenguer
A
A
Stacey
V E
VE
Qian
S Z
SZ
Xu
Y
Y
Zhang
J W
JW
Sanders
J K
JK
Amor
S R
SR
Pearce
C M
CM
D000818:Animals; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004852:Epoxy Compounds; D005298:Fertility / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009929:Organ Size / Q000187:drug effects; D010616:Phenanthrenes; D051381:Rats; D012690:Serial Extraction; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013607:Tablets; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D004852:Epoxy Compounds; D010616:Phenanthrenes; D013089:Spermatocidal Agents; D013607:Tablets; C068051:tripchlorolide; C001899:triptolide; C001898:tripdiolide