Copper benzochlorin, a novel photosensitizer for photodynamic therapy: effects on a transplantable urothelial tumor.
An iminium salt of octaethylbenzochlorin with copper in the aromatic ring, CDS1, was tested for its tumoricidal effects on the AY-27 N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide tumor line. CDS1 was found to be an effective photosensitizer in vivo when used in combination with either a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDS1 and light caused a rapid decrease in tumor blood flow. Skin photosensitization was found to be minimal when drug-injected mice were illuminated in a solar simulator.
Selman
S H
SH
Department of Urology, Medical College of Ohio.
Hampton
J A
JA
Morgan
A R
AR
Keck
R W
RW
Balkany
A D
AD
Skalkos
D
D
D000818:Animals; D003905:Deuteroporphyrins / Q000627:therapeutic use* / Q000633:toxicity*; D007097:Imines / Q000627:therapeutic use* / Q000633:toxicity*; D008027:Light; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D003905:Deuteroporphyrins; D007097:Imines; D017319:Photosensitizing Agents; C081504:copper benzochlorin