Pharmacology and toxicology of chemotherapeutic agents.
Emergency physicians often must evaluate symptomatic cancer patients receiving chemotherapeutic agents. When assessing patients being administered such highly toxic agents that have a narrow therapeutic index, fundamental understanding of the pharmacology and recognition of the toxic manifestations is mandatory. This article reviews some of the more commonly used chemotherapeutic agents, with particular emphasis on their indications, mechanisms of action, and toxicity.
Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona.
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D000477:Alkylating Agents / Q000009:adverse effects / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D014748:Vinca Alkaloids / Q000009:adverse effects / Q000494:pharmacology
D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D014748:Vinca Alkaloids