Second malignant neoplasms after treatment for osteosarcoma: a report of three cases.
We report second malignant neoplasms which developed between 7 and 19 years after treatment in 3 pediatric patients with osteosarcoma. Two patients had been treated with only surgery, and another patient had been treated with a combination of surgery with chemotherapy and radiation therapy for primary lesions. Pediatric patients with osteosarcoma, in particular, require careful long-term follow-up to monitor not only metastases but also development of second malignant neoplasms.
Ozaki
T
T
Department of Orthopaedic Surgery, Okayama University Medical School, Japan.
Sugihara
S
S
Inoue
H
H
D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology / Q000628:therapy*