Induction of hepatocellular carcinomas in the Egyptian toad Bufo regularis by an antifungal drug (griseofulvin).
Neoplastic lesions (hepatocellular carcinomas) were induced in the liver in 18 of 100 experimental toads (Bufo regularis) force fed with the antifungal drug griseofulvin, at a dose level of 0.4 mg/50 g every day. Maximal time of exposure and observation was 12 weeks. The first tumors appeared in 2 male toads 4 weeks after the initiation of feeding.
el-Mofty
M M
MM
Zoology Department, Faculty of Science, University of Alexandria, Egypt.
Khudoley
V V
VV
Essawy
A E
AE
Abdel-Kerim
H M
HM
D000818:Animals; D002025:Bufonidae; D005260:Female; D006118:Griseofulvin / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D013997:Time Factors
D006118:Griseofulvin