[A one year study of single administration of nilvadipine. Results of the effectiveness and long-term tolerance in hypertension].
OBJECTIVE
To test the efficacy and long-term tolerability of a single daily dose of nilvadipine.


METHODS
Open, multicenter follow-up study of 8-months duration following a 4-month randomized double-blind preliminary study (vs. nifedipine).


METHODS
307 ambulatory hypertensives with a diastolic blood pressure of < or = 95 mm Hg at the end of the preliminary study.


METHODS
One capsule of nilvadipine retard 8 or 16 mg taken once a day (in the morning).


METHODS
Monthly recording of blood pressure, pulse rate and body weight, and any adverse reactions: global assessment by the physician of tolerability and efficacy in month 12; in addition, ECG and laboratory parameters in months 6, 9 and 12.


RESULTS
In more than 95% of the patients, nilvadipine reduced blood pressure to normal levels. Some 95% of the physicians investigated assessed efficacy and tolerability to be "good" to "very good". The direct changeover of medication from nifedipine t.i.d. to a single daily dose of nilvadipine presented no problems.
Faust
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D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine
Einjahresstudie über die Einmalgabe von Nilvadipin. Ergebnisse zur Wirksamkeit und Langzeitverträglichkeit bei Hypertonikern.