Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system.
The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene glycol/water cosolvent systems. The AUC (drug concentration in acce ptor membrane as a function of time) and the diffusivity of the drug in the vehicle were used to evaluate the results of the in vitro transport. The importance and relationship between solubility, partition coefficient, and diffusivity for the process of in vitro penetration of 1 are discussed.
Bendas
B
B
Lehrstuhl für Biopharmazie der Universität Halle.
Göpferich
A
A
Lee
G
G
Neubert
R
R
D001624:Betamethasone Valerate / Q000737:chemistry / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005782:Gels; D008567:Membranes, Artificial; D012996:Solutions
D005782:Gels; D008567:Membranes, Artificial; D012996:Solutions; D001624:Betamethasone Valerate