Bacterial flora detected in the uterine endometrial cavity of normal puerperae on the puerperal first day and on the puerperal fifth day after incidental use of cefpodoxime proxetil.
In Japan, oral antimicrobial agents are prophylactically used with oxytocics after normal delivery to prevent puerperal infections. The present study was designed to investigate bacterial floras in the endometrial cavity immediately after normal delivery and the effect of prophylactic use of anti-microbial agents on those floras. Sixty-six puerperae who underwent uneventful courses of pregnancy and delivery were subjected for this study. Intrauterine contents were collected on the first day and the fifth day of the puerperium and submitted to microbiological examinations. Cefpodoxime proxetil (CPDX-PR) was orally given to the puerperae for prophylaxis for 5 days after the initial sampling. On the puerperal first day, a total of 98 strains (71 strains of aerobic bacteria, 27 strains of anaerobic bacteria) was detected in the uteri of the 66 subjects. The incidences of aerobic Gram-positive cocci, aerobic Gram-negative bacilli and anaerobic bacteria were 59.2%, 12.2%, 27.6% of the 98 strains, respectively. On the puerperal fifth day, a total of 82 strains (51 strains of aerobic bacteria and 31 strains of anaerobic bacteria) were detected in the uteri of the 66 subjects. The incidences of aerobic Gram-positive cocci, aerobic Gram-negative bacilli and anaerobic bacteria were 52.5%, 8.6% and 37.7% of 82 strains, respectively.
Department of Obstetrics and Gynecology, School of Medicine, Gifu University.
H
H
Mikamo
K
K
Izumi
K
K
Ito
H
H
Sawamura
K
K
Sawa
K
K
Watanabe
K
K
Ueno
T
T
Tamaya
D000284:Administration, Oral; D001419:Bacteria / Q000302:isolation & purification*; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D011292:Premedication; D011645:Puerperal Infection / Q000517:prevention & control*; D013997:Time Factors; D014599:Uterus / Q000382:microbiology*; D000097627:Cefpodoxime Proxetil
D015296:Ceftizoxime; D000097627:Cefpodoxime Proxetil