The regulatory diversity of the mammalian adenylyl cyclases.
Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca(2+)-amplified cAMP signals, synergism between Ca2+ and cAMP-activated kinases, and positive feedback regulation of Ca2+ channels by cAMP-dependent protein kinase.
Department of Pharmacology, University of Washington, Seattle 98195.
E J
EJ
Choi
Z
Z
Xia
E C
EC
Villacres
D R
DR
Storm
D000262:Adenylyl Cyclases / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D002118:Calcium; D002147:Calmodulin; D014644:Genetic Variation; D007527:Isoenzymes; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*
D002147:Calmodulin; D007527:Isoenzymes; D000262:Adenylyl Cyclases; D002118:Calcium