Multisection proton MR spectroscopic imaging of the brain.
The authors developed a hydrogen-1 proton magnetic resonance (MR) imaging method in which metabolic information is acquired by obtaining multiple sections through the brain. A spin-echo sequence is used for section selection, an octangular outer volume saturation pulse for lipid suppression, and a chemical-shift-selective saturation pulse for water suppression. High-quality maps of choline, creatine, and N-acetylaspartate were obtained in six studies performed in four volunteers. Water and lipid signal from the skull area was well suppressed by the pulse sequence used.
Duyn
J H
JH
Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892.
Gillen
J
J
Sobering
G
G
van Zijl
P C
PC
Moonen
C T
CT
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D008055:Lipids; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D014867:Water
D008055:Lipids; D014867:Water; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline