In vitro activity of cycloguanil against African isolates of Plasmodium falciparum.
The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.
Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, Paris, France.
L K
LK
Basco
O
O
Ramiliarisoa
P
P
Ringwald
J C
JC
Doury
J
J
Le Bras
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008099:Liver / Q000469:parasitology; D016778:Malaria, Falciparum / Q000469:parasitology; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D002727:Proguanil; D014227:Triazines / Q000494:pharmacology*
D014227:Triazines; C026009:cycloguanil; D002727:Proguanil