Laparoscopic partial nephrectomy in the pig model.
In an effort to further evaluate the potential application of laparoscopy to urologic surgery, we explored the feasibility of using this minimally invasive approach for performing a partial nephrectomy. Nine female pigs underwent laparoscopic partial nephrectomy (LPN) utilizing a plastic cable tie (15 mm. x 4 mm. x 1 mm.) to achieve renal ischemia and an Argon Beam Coagulator probe (ABC) (Birtcher Medical Systems) to fulgurate the transected surface. Six weeks after LPN, 6 pigs underwent creatinine clearance, renin level, arteriography, BP samples and were then killed. The renal remnants were weighed and sectioned for histological studies. These studies revealed excellent function of the renal remnant, no AV fistula, and no evidence of renovascular hypertension. LPN is a feasible, repeatable procedure in the pig. Control of the renal hilum, transient parenchymal compression with a plastic cable, and use of the argon beam coagulator are key elements in performing this procedure.
Department of Surgery (Division of Urology), Washington University School of Medicine, St. Louis, Missouri 63141.
E M
EM
McDougall
R V
RV
Clayman
P S
PS
Chandhoke
K
K
Kerbl
A M
AM
Stone
M R
MR
Wick
M
M
Hicks
R S
RS
Figenshau
D000818:Animals; D004564:Electrocoagulation / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D007668:Kidney / Q000473:pathology; D010535:Laparoscopy; D009392:Nephrectomy / Q000379:methods*; D013552:Swine