Early experimental studies on hemoperfusion as a treatment modality for acute radiation disease.
First results of the studies on hemoperfusion therapy of acute radiation disease that were conducted in Kiev in 1976 are presented. In these studies, 69 mongrel dogs were exposed to irradiation at a dose of 525 rad (5.25 Gy). It was proved that hemoperfusion through uncoated synthetic activated carbons led to a noticeable increase in their survival rate, from 3.2% in the control group (n = 31) to 68.4% and 62.4% for the dogs that received extracorporeal treatment at 2 h (n = 19) and 24 h (n = 19) after irradiation, respectively.
Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Academy of Sciences of Ukraine, Kiev.
V G
VG
Nikolaev
L B
LB
Pinchuk
M A
MA
Umansky
V G
VG
Pinchuk
T N
TN
Burushkina
S V
SV
Petrenko
N K
NK
Rodionova
E A
EA
Snezhkova
N P
NP
Bichkova
D000208:Acute Disease; D000818:Animals; D001772:Blood Cell Count; D004285:Dogs; D006464:Hemoperfusion; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000628:therapy*