[The influence of rush immunotherapy on the production of interleukin-5 from mononuclear cells].
We investigated the influence of rush immunotherapy (RI) on the production of interleukin (IL)-5 from peripheral blood mononuclear cells (PBMC) in asthmatics sensitive to Dermatophagoides farinae (Df). The levels of IL-5 produced varied among the subjects, and these levels were not affected by the addition of Df, regardless of RI. When IL5 levels were individually compared before and after RI, some cases demonstrated an apparent decrease in production at 16 weeks after RI. It is considered that further study will be needed to confirm whether or not immunotherapy can truly suppress the production of IL-5.
Second Department of Internal Medicine, Saitama Medical School.
M
M
Nagata
M
M
Shibasaki
Y
Y
Sakamoto
K
K
Yamamoto
Y
Y
Dohi
D000293:Adolescent; D000328:Adult; D000818:Animals; D001249:Asthma / Q000378:metabolism / Q000628:therapy*; D002478:Cells, Cultured; D003888:Desensitization, Immunologic; D006801:Humans; D015848:Interleukin-5 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008925:Mites / Q000276:immunology
D015848:Interleukin-5