[Blood flow pattern and tumor vascular change following intraperitoneal administration of CDDP in VX2 ovarian tumor].
Following intraperitoneal(IP) administration of cis-diamminedichloroplatinum(CDDP), a dynamic study was conducted on rabbits in Angiotensin II(ATII) induced hypertension to investigate hemodynamic changes in VX2 ovarian tumors. VX2 tumors for transplantation were prepared in Japanese white female rabbits. 15mg/kg of CDDP in 30ml/kg 0.9% NaCl solution was IP administration to the rabbits. The tissue platinum(Pt) concentration was measured and tumor vascular model prepared. The rabbits also received IP combined with 1.2g/kg intravenous administration of sodium thiosulfate(STS), and a hemodynamic study was run on rabbits with ATII induced hypertension two weeks after administration. IP administration resulted in tissue Pt levels as high as 18.50 +/- 8.05 micrograms/g in the VX2 ovarian tumors, with a tiny non-enhanced area appearing in the rim enhancement, consistent with necrotic changes. The tumor time-density curve following IP was characterized by a markedly delayed washout, with many hypovascular portions noted in the vascular model and a clear decrease in tumor vessels measuring 30 microns or less. in contrast, the peak value increased in the time-density curve and there was washout in the excretory phase following ATII induced hypertension. In view of the results, we suggest that a microcirculatory disorder resulting from IP administration could be improved under ATII induced hypertension.
1st Department of Obstetrics and Gynecology, Toho University School of Medicine, Tokyo.
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Hasegawa
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007263:Infusions, Parenteral; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D000804:Angiotensin II; D002945:Cisplatin