Direct influence of morphine on the release of arachidonic acid and its metabolites.
The influence of 10(-10)-10(-6) M morphine on the release of [3H]arachidonic acid and its metabolites ([3H]AAM) from prelabeled resident peritoneal murine macrophages was investigated. Morphine enhanced [3H]AAM release from A23187- and LPS-stimulated macrophages, as well as the basal release of [3H]AAM. Dose-response curves showed a maximum at 10(-8) M morphine. Naloxone had no effect on morphine enhancement of [3H]AAM release. These results are in agreement with the hypothesis that [3H]AAM may be involved in the effects of morphine.
Sergeeva
M G
MG
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russian Federation.
Terentjeva
I V
IV
Mevkh
A T
AT
Varfolomeev
S D
SD
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D002478:Cells, Cultured; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010537:Peritoneum / Q000166:cytology
D001095:Arachidonic Acids; D000001:Calcimycin; D009020:Morphine