Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation.
In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. A system of one six-membered and two five-membered rings, formed by the metal and the donor atoms of the ligand, may constitute a basic structure for the development of new indium tracers with myocardial affinity.
Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. Demokritos, Attiki, Greece.
C
C
Cotsyfakis
A D
AD
Varvarigou
M
M
Papadopoulos
S
S
Stathaki
C I
CI
Stassinopoulou
E
E
Chiotellis
D000818:Animals; D003287:Contrast Media; D003543:Cysteamine / Q000031:analogs & derivatives / Q000737:chemistry; D006321:Heart / Q000000981:diagnostic imaging*; D007205:Indium Radioisotopes; D051379:Mice; D011877:Radionuclide Imaging; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014018:Tissue Distribution
D003287:Contrast Media; D007205:Indium Radioisotopes; D013438:Sulfhydryl Compounds; C060158:tetraethyl-bis(aminoethanethiol); D003543:Cysteamine