Monocyte-mediated restoration of density-dependent growth control and induction of cell death in tumor cell populations.
It is shown in a serum-free system with human cells that during monocyte/tumor cell interactions signals are generated which restore the principles of density-dependent inhibition of growth in tumor cell populations. Tumor cells that fail to comply with these principles are induced to die. This cell death is an active process in target cells involving protein biosynthesis and tumor cell-derived signals.
Rüller
S
S
Forschungsinstitut Borstel, Institut für experimentelle Biologie und Medizin, Germany.
van der Bosch
J
J
Horn
D
D
Schlaak
M
M
D016923:Cell Death / Q000187:drug effects; D002455:Cell Division; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D016895:Culture Media, Serum-Free; D003513:Cycloheximide / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D009000:Monocytes / Q000502:physiology*; D015846:Monokines / Q000494:pharmacology; D015398:Signal Transduction; D013997:Time Factors; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms
D017077:Culture Media, Conditioned; D016895:Culture Media, Serum-Free; D015846:Monokines; D003513:Cycloheximide