Listeria monocytogenes-induced interferon-gamma primes the host for production of tumor necrosis factor and interferon-alpha/beta.
Mice acquired an enhanced capacity for the production of tumor necrosis factor (TNF) and the interferons (IFN)-alpha, and -beta shortly after intravenous injection of viable Listeria monocytogenes. By the end of the first day of a sublethal infection, mice were primed to produce 100-1000 times more endotoxin-induced serum TNF than is produced by normal mice. Acquisition of the augmented capacity for TNF production was due to L. monocytogenes-induced IFN-gamma. IFN-gamma also primed infected mice for IFN-alpha/beta production. However, in addition to IFN-gamma, other L. monocytogenes-induced mechanisms endowed the host with an enhanced potential for the production of IFN-alpha/beta. Antibody-mediated depletion of various cell types in vivo revealed that CD8+ cells and NK cells are required for the production of L. monocytogenes-induced IFN-gamma during the first day of listeriosis.
Trudeau Institute, Inc., Saranac Lake, NY 12983.
E A
EA
Havell
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D005260:Female; D005677:G(M1) Ganglioside / Q000037:antagonists & inhibitors / Q000378:metabolism; D016898:Interferon-alpha / Q000096:biosynthesis*; D016899:Interferon-beta / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D016513:Mice, SCID; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000907:Antibodies, Bacterial; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D005677:G(M1) Ganglioside; D016899:Interferon-beta; D007371:Interferon-gamma