Endoscopic treatment of reflux: migration of Teflon to the lungs and brain.
We set out to determine experimentally whether particles of polytetrafluoroethylene migrate to the lungs and brain when relatively small volumes of Teflon paste are injected into the bladder in the manner used to correct reflux. Numerous particles of polytetrafluoroethylene were recovered from these organs within 2 weeks of injection. Those in the brain measured up to 15 microns in diameter, indicating that the pulmonary bed is an inefficient filter of particles gaining access to the venous circulation. Although clinically no adverse neurological effects have hitherto been reported, this study suggests that following the 'sting' procedure, some particles may lodge in the brain where they can block the cerebral microcirculation. We believe these findings represent a contraindication to the use of Teflon paste in children.
Department of Urology, Children's Hospital, Medical University of South Carolina, Charleston 29425.
I A
IA
Aaronson
R A
RA
Rames
W B
WB
Greene
L G
LG
Walsh
U A
UA
Hasal
P D
PD
Garen
D000818:Animals; D001923:Brain Chemistry; D004285:Dogs; D004577:Electron Probe Microanalysis; D004724:Endoscopy; D005260:Female; D005548:Foreign-Body Migration; D008168:Lung / Q000737:chemistry*; D011138:Polytetrafluoroethylene / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*; D014718:Vesico-Ureteral Reflux / Q000628:therapy*
D011138:Polytetrafluoroethylene