[Effect of 6-methyluracil on various indicators of the lipid peroxidation regulation system in the body].
Single intraperitoneal administration of 6-methyluracil in a dose of 50 mg/kg was shown to affect some patterns of the physico-chemical system regulating lipid peroxidation in mice liver tissue and erythrocytes: antioxidative activity of lipids (AOA), composition of phospholipids; the drug altered also activities of superoxide dismutase and catalase in liver tissue and blood serum of rats. These alterations observed had phase expressed dynamics and their rate was dissimilar in various tissues and depended on the interval after drug administration. 6-Methyluracil exhibited the highest effect on the rate of AOA in liver tissue and on phospholipid composition in erythrocytes. The biological activity of the drug appears related to its effects on the system regulating lipid peroxidation.
Iu P
IuP
Taran
L N
LN
Shishkina
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants; D002374:Catalase / Q000097:blood / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010743:Phospholipids / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D010743:Phospholipids; D014498:Uracil; C008378:6-methyluracil; D002374:Catalase; D013482:Superoxide Dismutase
Vliianie 6-metiluratsila na nekotorye pokazateli sistemy reguliatsii perekisnogo okisleniia lipidov v organizme.