EGF: new tricks for an old growth factor.
During the past year, the biology of epidermal growth factor (EGF) has been investigated in lower organisms (Caenorhabditis elegans, Drosophila and bacteria). These experiments have produced some surprising results: the identification of defects produced by mutation of EGF-like genes; the role of EGF receptors in bacterial invasion; and the role of EGF-like precursors as receptors for a bacteria toxin.
Carpenter
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Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0146.
D000818:Animals; D017173:Caenorhabditis elegans; D004330:Drosophila; D004815:Epidermal Growth Factor / Q000502:physiology*; D066246:ErbB Receptors / Q000502:physiology*; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D010766:Phosphorylation; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic / Q000737:chemistry; D012486:Salmonella typhimurium
D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D004815:Epidermal Growth Factor; D066246:ErbB Receptors