The NHLBI model: a 25 year history.
Although newer techniques and procedures have been developed, many of the clinical trial design and monitoring concepts used today in the NHLBI were implemented 25 years ago. Among these are the organizational structure of multicentre trials and the use of an independent data monitoring committee. Examples of data monitoring committee discussions and decisions are provided.
National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
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D002986:Clinical Trials as Topic / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic / Q000592:standards; D011367:Professional Staff Committees; D016032:Randomized Controlled Trials as Topic / Q000592:standards; D013223:Statistics as Topic