Uptake of radiolabeled anti-CEA antibodies in human colorectal primary tumors as a function of tumor mass.
An inverse correlation has been demonstrated between tumor uptake (u, in units of % injected dose/kg) of monoclonal antibody (Mab) and tumor mass (m, in units of g) for colorectal carcinoma in a series of 19 consecutive patients. The correlation (rho = -0.510), developed using surgical samples was of the form u = amb and was significant at the 2% level of confidence. All tumors were positive for carcinoembryonic antigen (CEA) and the radiopharmaceutical was an iodine-131 labeled anti-CEA Mab. Such correlations have been predicted earlier from murine and rat tumor uptake data. The slope parameter (b) was -0.362, a number consistent with the previous value (-0.382) found in anti-CEA experiments in mice bearing human xenograft LS174T tumors.
Division of Radiology, City of Hope National Medical Center, Duarte, CA 91010.
L E
LE
Williams
R B
RB
Bares
J
J
Fass
S
S
Hauptmann
V
V
Schumpelick
U
U
Buell
D002272:Carcinoembryonic Antigen / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007457:Iodine Radioisotopes; D016719:Radioimmunodetection
D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes