[Double blind comparative randomized study of the efficacy of celiprolol versus amiloride-hydrochlorothiazide in mild to moderate AHT].
We tried to assess the antihypertensive effectivity of a betablocker, celiprolol, in the control of mild to moderate essential arterial hypertension. A double-blind randomized comparative study was conducted between celiprolol and amiloride-hydrochlorothiazide in 40 patients with mild to moderate essential hypertension. Both drugs were effective in the therapeutical control of hypertension, although reductions in systolic blood pressure were more significant among the celiprolol group, being the percentage of patients with reduction of diastolic blood pressure below 90 mmHg., 89.5% in the celiprolol group and 82.4% in the amiloride group. The average dose of celiprolol used was 200 mg/day, with few mide effects.
Departamento de Medicina Interna, Hospital Universitario Virgen Macarena, Sevilla.
J
J
Oliván Martínez
M
M
Hoyos Jiménez
M J
MJ
Miranda García
E
E
Justo Alpañés
R
R
Pérez Cano
D000328:Adult; D000584:Amiloride / Q000627:therapeutic use*; D017272:Celiprolol / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D006852:Hydrochlorothiazide; D000584:Amiloride; D017272:Celiprolol
Estudio comparativo randomizado a doble ciego de la eficacia del celiprolol "versus" amiloride-hidroclorotiazida en la HTA ligera-moderada.