Pseudomyxoma peritonei: treatment with intraperitoneal 5-fluorouracil.
Four patients with pseudomyxoma peritonei associated with mucinous tumors of the ovary were treated with cytoreductive surgery followed by intraperitoneal (IP) 5-fluorouracil (5-FU). CA-125 was elevated in three, and ca cinoembryonic antigen (CEA) in one patient; both fell to within normal levels following treatment. Two patients underwent reassessment laparotomy and one a reassessment laparoscopy with no evidence of disease following chemotherapy. The fourth patient refused surgical reassessment but remains clinically free of disease. Intraperitoneal 5-FU appears to be effective in pseudomyxoma peritonei. Précis: Four patients with pseudomyxoma peritonei associated with ovarian tumors were successfully treated with surgery and intraperitoneal 5-FU.
Nasr
M F
MF
Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
Kemp
G M
GM
Given
F T
FT
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D017024:Chemotherapy, Adjuvant; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D011553:Pseudomyxoma Peritonei / Q000188:drug therapy* / Q000601:surgery; D012086:Reoperation
D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D005472:Fluorouracil