Neuromuscular blockade by use of atracurium in anesthetized llamas.
Anesthesia was induced in 8 healthy llamas by administration of guaifenesin and ketamine, and was maintained with halothane in oxygen. On 2 separate experimental days, atracurium was given to induce 95 to 99% reduction of evoked hind limb digital extensor tension (twitch). For the first part of the study, atracurium was given IV as repeat boluses, with muscle twitch strength being allowed to return without intervention to 75% of baseline after each bolus before the subsequent bolus was given. A total of 5 bolus doses of atracurium was given. For the first bolus, 0.15 mg/kg of body weight IV, and for subsequent boluses, 0.08 mg/kg, induced desired relaxation. Onset of relaxation was slightly more rapid for repeat, compared with initial, bolus. Duration of relaxation and recovery time were similar to initial and repeat doses. Maximal twitch reduction was observed in 4 +/- 0.2 minutes (mean +/- SEM). Duration from maximal twitch reduction to 10% recovery was 6.3 +/- 0.4 minutes. Twitch recovery from 10 to 50% of baseline took 11.6 +/- 0.6 minutes. Twitch recovery from 10 to 75% recovery took 19.5 +/- 1.1 minutes. Recovery from 10% twitch to 50% fade took 12.8 +/- 0.5 minutes. Fade at 50% recovery of twitch was 39 +/- 0.02%. Significant (P < 0.05) animal-to-animal variation was observed in twitch recovery times. For the second part of the study, atracurium was initially given IV as a 0.15-mg/kg bolus, followed by infusion for 1 to 2 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
Hildebrand
S V
SV
Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616-8745.
Hill
T
T
D000704:Analysis of Variance; D000768:Anesthesia, General; D000818:Animals; D001279:Atracurium / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002161:Camelids, New World; D004558:Electric Stimulation; D005152:Facial Muscles / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D005154:Facial Nerve / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006140:Guaifenesin; D006221:Halothane; D007275:Injections, Intravenous; D007649:Ketamine; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009919:Orchiectomy; D010543:Peroneal Nerve / Q000187:drug effects / Q000502:physiology*
D001279:Atracurium; D006140:Guaifenesin; D007649:Ketamine; D006221:Halothane