[Research on immune complex in situ type glomerulonephritis treated with mai-luo-tong in rabbits].
Applying c-BSA to duplicate immune complex in situ type glomerulonephritis in rabbits and treating it with Blood Circulation Promoting and Stasis-Removing Drugs Mai-Luo-Tong, the results showed that proteinuria in the treated group was decreased significantly, as compared to the control group (P < 0.01). Under light and electron microscope, although glomerular basement membrane was irregularly thickened and subepithelial dense electron deposits were found in both groups, but histopathologic damage in the treated group less than that of control one. In the treated group micro-thrombus, erythrocytes and platelets aggregation, leukocytes impaction were not seen within glomerular capillary. Also in the treated group mesangial cell proliferation and granulocyte infiltration were decreased significantly (P < 0.01) and there was no apparent glomerular fibrosis in former group.
Wang
Q L
QL
Tongji Hospital, Tongji Medical University, Wuhan.
Huang
S Z
SZ
Sun
S L
SL
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008297:Male; D011507:Proteinuria / Q000188:drug therapy; D011817:Rabbits; D012710:Serum Albumin, Bovine
D004365:Drugs, Chinese Herbal; D012710:Serum Albumin, Bovine