Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography-mass spectrometry.
Medetomidine, atipamezole and midazolam in pig plasma were determined by liquid chromatography-mass spectrometry (LC-MS) with an atmospheric pressure chemical ionization interface system by the use of detomidine as an internal standard. The method was applied to studies of pharmacokinetic behaviour of these drugs.
Kyoritsu College of Pharmacy, Tokyo, Japan.
H
H
Kanazawa
R
R
Nishimura
N
N
Sasaki
A
A
Takeuchi
N
N
Takai
Y
Y
Nagata
Y
Y
Matsushima
D000316:Adrenergic alpha-Agonists / Q000493:pharmacokinetics; D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics; D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods* / Q000706:statistics & numerical data; D008401:Gas Chromatography-Mass Spectrometry; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D007093:Imidazoles / Q000097:blood / Q000493:pharmacokinetics*; D007700:Kinetics; D013058:Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D020926:Medetomidine; D008874:Midazolam / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D020926:Medetomidine; D008874:Midazolam