Influence of carbamazepine on Li+ ratio in healthy volunteers: an in vitro method.
Thirty-six healthy volunteers, 19 men and 17 women, were selected to study the possible influence of carbamazepine on Li+ ratio in vitro. The study used within-Ss design. The procedure for preparing and calculating Li+ ratio in vitro followed Pandey's method. Twenty milliliters of blood was withdrawn from each subject, and divided evenly into three test tubes containing sodium heparin. Test tube 1 (control) went through the regular Pandey's method; test tube 2 went through the same procedure, except both the loading and incubation media contained 35 mu mol/L of carbamazepine. The result showed that carbamazepine did not significantly alter Li+ ratio in vitro. The neurotoxicity resulting from lithium-carbamazepine combination might be related to carbamazepine alone or preexisting physical conditions or interactions not related to Li+ ratio.
Department of Psychiatry, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.
Y Y
YY
Yang
H C
HC
Deng
D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008094:Lithium / Q000097:blood*; D008297:Male; D012016:Reference Values
D002220:Carbamazepine; D008094:Lithium