Axonal loss in band atrophy of the optic nerve in craniopharyngioma: a quantitative analysis.
Automated image analysis was used to examine the optic nerves of a patient with previous craniopharyngioma and bitemporal hemianopsia. On histologic study the right optic nerve showed extensive damage, and the left optic nerve showed a band of damage horizontally across the nerve. Automated image analysis of the left nerve showed that the superior and inferior poles of the nerve had lost approximately 50% of their total nerve fibres, indicating that these areas contain a mixture of crossed and uncrossed fibres; the temporal portion showed a variable amount of loss. To our knowledge this is the first report illustrating quantitatively the pattern of axonal loss in this type of lesion.
Department of Ophthalmology, University of British Columbia, Vancouver.
F S
FS
Mikelberg
H M
HM
Yidegiligne
D000328:Adult; D001284:Atrophy; D001369:Axons / Q000473:pathology*; D002452:Cell Count; D003397:Craniopharyngioma / Q000150:complications / Q000473:pathology*; D006423:Hemianopsia / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D009900:Optic Nerve / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology*; D015354:Vision, Low / Q000209:etiology / Q000473:pathology; D014792:Visual Acuity; D014794:Visual Fields