Effect of lanthanum ions on the release of acetylcholine induced by tityustoxin, K+ and ouabain from myenteric plexus and brain cortical slices.
Exposure of myenteric plexus longitudinal muscles to 2 mM LaCl3 increased the rate of spontaneous [3H]-ACh release. In brain cortical slices La3+ did not affect the spontaneous release of ACh. The release of ACh induced by tityustoxin, ouabain or K+ 50 mM in brain cortex and myenteric longitudinal muscles slices was inhibited by La3+ treatment. It is suggested that tityustoxin, ouabain and K+ release ACh from the same pool that is inhibited by La3+ pretreatment.
Gomez
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RS
Departamento de Farmacologia, Instituto de Ciências Biológicas, UFMG, Belo Horizonte, Brazil.
Moraes-Santos
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T
Gomez
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MV
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology*; D008297:Male; D009197:Myenteric Plexus / Q000187:drug effects / Q000378:metabolism*; D009498:Neurotoxins / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*
D009498:Neurotoxins; D012604:Scorpion Venoms; C003609:tityustoxin; D010042:Ouabain; D007811:Lanthanum; D000109:Acetylcholine; D011188:Potassium