Extracellular matrix proteins in intrathymic T-cell migration and differentiation?
Intrathymic T-cell migration and differentiation is not completely understood. Here, Wilson Savino and colleagues argue that certain interactions between differentiating thymocytes and thymic epithelial cells are mediated by extracellular matrix proteins and that these interactions influence intrathymic migration events and thymocyte differentiation.
Department of Immunology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
W
W
Savino
D M
DM
Villa-Verde
J
J
Lannes-Vieira
D002450:Cell Communication; D002454:Cell Differentiation; D002465:Cell Movement; D004847:Epithelial Cells; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology*
D016326:Extracellular Matrix Proteins; D016023:Integrins