Anorectic specificity as measured in a choice paradigm in rhesus monkeys.
The present report describes a new procedure for assessing anorectic specificity. Two rhesus monkeys (Macaca mulatta) surgically prepared with indwelling intragastric catheters were trained in a discrete trial choice paradigm to respond for either food or visual access to a room containing other monkeys. Our hypothesis was that a specific anorectic would reduce only food-maintained responding; responding to open a window would either not be affected or would increase. Caloric preloads, d-amphetamine, (d,l)-fenfluramine, and cholecystokinin octapeptide all decreased food-maintained responding and had no effect on or increased responding maintained by window opening. These results demonstrate that choice procedures are useful for assessing anorectic specificity.
Department of Psychiatry, University of Chicago, IL 60637.
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Corwin
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Schuster
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology; D005502:Food; D008253:Macaca mulatta; D008297:Male; D012646:Self Administration
D001067:Appetite Depressants; D005277:Fenfluramine; D002766:Cholecystokinin; D000661:Amphetamine