Decreased serum cholesterol level after snake bite (Vipera palaestinae) as a marker of severity of envenomation.
In 44 patients bitten by snakes (Vipera palaestinae), admission serum cholesterol levels were negatively correlated with severity of envenomation (mean +/- SD, 175 +/- 49, 137 +/- 36, and 96 +/- 40 mg/dl, respectively, in cases with mild, moderate, and severe clinical manifestations [p < 0.0001]). Concomitant decreases in serum albumin were not significant. These findings were supported by experimental results in rabbits, in which low, medium, and high doses of purified V. palaestinae venom (all in the non-lethal range), led to dose-dependent decreases in serum cholesterol, at 180 minutes, of 9.5% +/- 8.9%, 18.6% +/- 10.1%, and 32.7% +/- 11.8%, respectively (p < 0.01). This rapid decrease in serum cholesterol level is only partially explained by transcapillary lipoprotein leakage and probably indicates changes in lipoprotein transport and metabolism caused by the phospholipase A2 component of V. palaestinae venom. Admission total serum cholesterol level may serve as an indicator of severity of envenomation in patients bitten by snakes of the Vipera genus before full development of the clinical syndrome.
Clinical Toxicology and Pharmacology Unit, Sheba Medical Center, Tel Hashomer, Israel.
E
E
Winkler
M
M
Chovers
S
S
Almog
S
S
Pri-Chen
M
M
Rotenberg
M
M
Tirosh
D
D
Ezra
H
H
Halkin
D000328:Adult; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000032:analysis / Q000502:physiology; D054467:Phospholipases A2; D011817:Rabbits; D012720:Severity of Illness Index; D012909:Snake Bites / Q000097:blood*; D014757:Viper Venoms / Q000032:analysis / Q000494:pharmacology
D014757:Viper Venoms; D002784:Cholesterol; D010741:Phospholipases A; D054467:Phospholipases A2