[The role of eosinophil in nasal allergy].
In this paper, the function of the eosinophil, activation of the eosinophil and degranulation of eosinophil granules are discussed. The in vitro mechanism of eosinophil-induced tissue injury has been reported previously. We have reported that most of the eosinophils in the inferior turbinate mucous membrane of nasal allergy were positive to EG2 and have also reported that extracellular deposits of EG2, MBP and EPO were mainly found in the superficial lamina propria. However, damage of the epithelia did not relate to the infiltration of EG2, MBP and EPO. The damage of the basement membrane could not be found. The concept of tissue injury induced by eosinophil, is controversial, and further study is required to elucidate the function of the eosinophil, in vivo.
Yoshimi
R
R
Department of Otolaryngology, School of Medicine, Nagasaki University.
D001798:Blood Proteins / Q000378:metabolism; D015550:Cell Degranulation; D047091:Eosinophil Granule Proteins; D047209:Eosinophil Peroxidase; D004804:Eosinophils / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009093:Mucus / Q000378:metabolism; D009297:Nasal Mucosa / Q000166:cytology*; D010544:Peroxidases / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology* / Q000473:pathology; D012260:Ribonucleases; D013601:T-Lymphocytes
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D047209:Eosinophil Peroxidase; D010544:Peroxidases; D012260:Ribonucleases