In vitro micronucleus test of the cardioprotective agent stobadine. A genotoxicological study.
The genotoxic effect of stobadine (1) was studied in vitro using the micronucleus test. Hamster and human fibroblastoid cells were used. In hamster cells, the highest concentration of 1 (1.10(-3) mol/l) caused a significant elevatin in the number of micronuclei, while in human cells no positive response was found for either of the concentrations used. Stobadine had no genotoxic effect on human fibroblastoid cells.
Cancer Research Institute, Bratislava, Slovakiá.
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Chalupa
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Blasko
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Benes
D000818:Animals; D002243:Carbolines / Q000633:toxicity*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*
D002243:Carbolines; D009153:Mutagens; C100106:dicarbine