Antimicrobial strategies in the prevention of dental caries.
Antimicrobial agents, applied either professionally or delivered from dentifrices or mouthwashes, could reduce caries by controlling plaque formation, suppressing cariogenic species, or by inhibiting bacterial metabolism. Chlorhexidine has proven anticaries activity; other agents might also prevent caries by means of their antiplaque properties. Sugar substitutes stabilize the microflora by reducing the number of acid challenges to plaque and stimulating saliva flow; some also have antimicrobial properties, especially against mutans streptococci. Vaccines have been prepared from purified antigens of mutans streptococci. These vaccines confer protection in non-human primates, but have yet to be tested in a human clinical trial.
Pathology Division, PHLS Centre for Applied Microbiology and Research, Salisbury, UK.
P D
PD
Marsh
D000470:Alkaloids / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001428:Bacterial Vaccines; D053119:Benzophenanthridines; D002594:Cetylpyridinium / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D003300:Copper / Q000627:therapeutic use; D003731:Dental Caries / Q000382:microbiology* / Q000517:prevention & control*; D006801:Humans; D007546:Isoquinolines; D007778:Lactobacillus / Q000187:drug effects / Q000378:metabolism; D008610:Menthol / Q000627:therapeutic use; D012967:Sodium Dodecyl Sulfate / Q000627:therapeutic use; D013291:Streptococcus / Q000187:drug effects / Q000378:metabolism; D013295:Streptococcus mutans / Q000187:drug effects / Q000378:metabolism; D013549:Sweetening Agents / Q000378:metabolism / Q000627:therapeutic use; D014260:Triclosan / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use
D000470:Alkaloids; D000891:Anti-Infective Agents, Local; D001428:Bacterial Vaccines; D053119:Benzophenanthridines; D007546:Isoquinolines; D013549:Sweetening Agents; D008610:Menthol; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan; D003300:Copper; C005705:sanguinarine; D002594:Cetylpyridinium; D015032:Zinc; D002710:Chlorhexidine