Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury.
Administration of methylprednisolone within several hours after injury to the spinal cord has been shown to reduce subsequent impairment in humans and experimental animals. Secondary damage following initial trauma is probably caused in part by the toxicity of released excitatory amino acids. We demonstrate here that methylprednisolone reduces the release of excitatory amino acids following experimental spinal cord injury in rats.
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555.
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McAdoo
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism*
D000596:Amino Acids; D008775:Methylprednisolone