Effects of triiodothyronine on canine hepatic ischemia caused by Pringle's maneuver.
BACKGROUND
A significant reduction in the serum concentration of triiodothyronine is frequently observed in surgical stress and may influence the severity and prognosis of the underlying disease.


METHODS
Alterations of thyroid hormone levels and effects of triiodothyronine were evaluated in the shock state after Pringle's maneuver for 60 minutes in dogs. Triiodothyronine (1 micrograms/kg/hr) was infused intravenously for 3 hours after declamping in the triiodothyronine-treated group. The effect of triiodothyronine on hepatic mitochondrial function was investigated by measuring the arterial ketone body ratio (AKBR).


RESULTS
In the control group (n = 6) the low triiodothyronine syndrome was observed and progressive deterioration of AKBR and standard liver functions represented by aspartate aminotransferase, glutamic-pyruvic transaminase, and lactic dehydrogenase were noted after declamping. All dogs went into shock and died within 24 hours. By contrast, in the triiodothyronine-treated group (n = 6), hemodynamics were stabilized and standard liver functions were maintained favorably (p < 0.01). AKBR was fully restored to the preischemic liver within 30 minutes after declamping, with a decrease in serum lactate levels (p < 0.05). All dogs survived at least 7 days after operation (p < 0.01).


CONCLUSIONS
These results indicate that triiodothyronine has beneficial effects on cytoprotection, hemodynamics, and hepatic energy metabolism in the ischemic liver injury. Furthermore, it improves survival in the shock state after Pringle's maneuver.
Ino
K
K
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Manaka
D
D
Washida
M
M
Yokoyama
T
T
Okamoto
R
R
Yamaoka
Y
Y
Ozawa
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007511:Ischemia / Q000503:physiopathology*; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000601:surgery*; D014284:Triiodothyronine / Q000494:pharmacology*
D007657:Ketone Bodies; D014284:Triiodothyronine