Pathophysiology and treatment of circulatory shock.
Circulatory shock is a syndrome characterized by imbalance between oxygen supply and demand. Myriad different mediators are responsible for the systemic manifestations of shock. The therapeutic approach requires initial interventions directed at increasing oxygen delivery followed by definitive therapy for the causative process. Areas of ongoing research involve mediated-directed therapy, reperfusion injury, and immunologic interventions directed at reducing infectious complications in the survivors of circulatory shock.
Department of Medicine, St. Vincent's Hospital and Medical Center, New York, New York.
M E
ME
Astiz
E C
EC
Rackow
M H
MH
Weil
D000818:Animals; D003422:Critical Care; D016207:Cytokines / Q000502:physiology; D004285:Dogs; D004298:Dopamine / Q000627:therapeutic use; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood / Q000378:metabolism; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy; D012769:Shock / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D015996:Survival Rate
D016207:Cytokines; D007773:Lactates; D019344:Lactic Acid; D010100:Oxygen; D004298:Dopamine