[Effects of microiontophoretically applied ACH and atropine on the electric activities of neurons in nucleus parafascicularis of thalamus in rats].
The effects of acetylcholine (ACh) and atropine on the electric activities of neurons of nucleus parafascicularis thalami (Pf) were observed in anesthetized rats with multimicropipette technique and iontophoresis. It was found that the spontaneous and pain-induced discharges of the Pf neurons were excited and some of non-nociceptive neurons became sensitive to nociceptive stimulation with microiontophoretically applied ACh, while microiontophoretically applied atropine could diminish the spontaneous and pain-induced discharges of the Pf neurons. The effects of ACh above could be blocked by microiontophoretically applied atropine. The results show that ACh may have excitatory effects on the electric activity of the Pf neurons by M-receptor.
Zhang
L X
LX
Department of Physiology, Tongji Medical University, Wuhan.
Liu
Z Y
ZY
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013787:Thalamic Nuclei / Q000187:drug effects* / Q000502:physiology
D001285:Atropine; D000109:Acetylcholine