Psychosexual behavior in hypopituitary men: a controlled comparison of gonadotropin and testosterone replacement.
Nine gonadotropin-deficient hypopituitary men were cycled through periods of treatment with testosterone (T), gonadotropin (Gn), and placebo (Pl) using a blind cross-over design. Self-reports of sexual behavior, recordings of nocturnal penile tumescence (NPT), and sex steroid levels were obtained during each treatment period. Subjects had significantly higher plasma T during the T and Gn treatments than during the control periods. Similarly, self-reported frequency of ejaculation and ratings of libido as well as duration measures of NPT were significantly higher on T and Gn. Two thirds of the sample had no sociosexual experience. Behavioral differences between the T and Gn periods were minimal. These data support the hypothesis that Gn and T are equally effective in stimulating specific aspects of male psychosexual behavior.
Department of Psychiatry, State University of New York, Buffalo.
R R
RR
Clopper
M L
ML
Voorhess
M H
MH
MacGillivray
P A
PA
Lee
B
B
Mills
D000293:Adolescent; D000328:Adult; D004542:Ejaculation / Q000502:physiology; D006062:Gonadotropins / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use* / Q000652:urine; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000503:physiopathology; D007018:Hypopituitarism / Q000188:drug therapy / Q000503:physiopathology*; D007989:Libido / Q000502:physiology; D007986:Luteinizing Hormone / Q000652:urine; D008297:Male; D010413:Penis / Q000502:physiology; D012725:Sexual Behavior / Q000502:physiology / Q000523:psychology*; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use* / Q000652:urine
D006062:Gonadotropins; D013739:Testosterone; D007986:Luteinizing Hormone