Peripherally administered serotonin induces hyperglucagonemia in mice.
Peripherally administered serotonin (5-HT) induced a marked increase in the plasma glucagon level in mice. The hyperglucagonemic effects of 5-HT were completely antagonized by methysergide, ketanserin and ritanserin which have a high affinity for 5-HT2 receptors. However, the 5-HT3 receptor antagonist ICS 205-930 and MDL 72222 were without effect. These findings suggest that the activation of the peripheral 5-HT2 receptor induces the increase in plasma glucagon level and that these receptors may play a role in the release of glucagon.
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
J
J
Yamada
Y
Y
Sugimoto
I
I
Kimura
Y
Y
Watanabe
N
N
Takeuchi
K
K
Horisaka
D000818:Animals; D005934:Glucagon / Q000097:blood* / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D012701:Serotonin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology; D000077526:Tropisetron
D007211:Indoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D014326:Tropanes; D016713:Ritanserin; D012701:Serotonin; D000077526:Tropisetron; D005934:Glucagon; C047087:5-carboxamidotryptamine; D007650:Ketanserin; C042253:bemesetron; D008784:Methysergide