Cortical plasticity and memory.
The roles of extrinsically modulated, plastic Hebb-like synapses and dynamic cortical cell assemblies underlying cortical plasticity in learning and memory operations are described. From our understanding of the distributed form of representation of learned behaviors in somatosensory and auditory cortical fields, and given new findings about the nature and distribution of responses representing learned and remembered stimuli in the inferior temporal cortex, a hypothetical picture of the cortical engram representing learned behaviors and memories is posited.
Keck Center, University of California, San Francisco 94143-0732.
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MM
Merzenich
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Sameshima
D000344:Afferent Pathways / Q000502:physiology; D000375:Aging / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003714:Denervation; D006801:Humans; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity; D013569:Synapses / Q000502:physiology