Chromosomal aberrations in two sporadic gastrinomas.
Results of cell culture and cytogenetic analysis (standard and fluorescent in situ hybridization, FISH) of two sporadic gastrinomas are reported. Maintenance of hormonal activity was assessed by detection of gastrin levels during the first 3 months in culture. Case 1 showed clonal aberrations consisting of two marker chromosomes: marker 1 is a large metacentric chromosome and marker 2 is a small acrocentric chromosome. Case 2 showed a constitutional polymorphism with chromosome 15p+ and a clone in the tumor cell culture with trisomy for chromosome 3. To our knowledge, this is the first cytogenetic report of sporadic gastrinomas (Zollinger-Ellison syndrome).
Center for Molecular Biology, Wayne State University, Detroit, MI.
M E
ME
Herrmann
L L
LL
Rydstedt
G B
GB
Talpos
K T
KT
Trevor
S R
SR
Wolman
A N
AN
Mohamed
S
S
Ratner
P A
PA
Lalley
D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D004379:Duodenal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015408:Gastrinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged
D005755:Gastrins