Computer simulation of fractionated radiotherapy: further results and their relevance to percutaneous irradiation and brachytherapy.
Based on previous papers, the present communication considers the simulation of the radiotherapeutic treatments of glioblastoma multiforme, rectum adenocarcinoma, and gynaecological tumors of cervix uteri (squamous and adenocarcinoma) in spheroid culture. Starting with a single tumor cell in a nutrient medium and after the corresponding growth of the tumor spheroids, varying irradiation schemes are applied to the carcinoma and are compared with regard to tumor kill effectiveness using the LQ-model. The two first-mentioned carcinoma are exposed to the dose fractionation schemes standard-, super-, hyperfractionation, and weekly high single dose. The result is that hyperfractionation (3 x 1.5 Gy/day) and weekly high single dose (1 x 6 Gy/week) yield the most effective tumor cell kill. The weekly high single dose may be realized by some different irradiation techniques, e. g. stereotactic irradiation or interstitial high dose rate brachytherapy. The treatment of the cervix uteri tumors is performed by a combined therapy form (high dose rate brachytherapy and percutaneous irradiation). A comparing simulation of two typical regimens yields a nearly equivalent tumor kill effectiveness. By the integration of in vitro tumor growth and clinical treatment schemes in a computer model, the possibility is made available to test the effectiveness of variable regimens with the help of computer experiments.
Department of Electrical Engineering, University of Siegen, Germany.
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D000279:Administration, Cutaneous; D001918:Brachytherapy; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage