Superiority of oral agar and phototherapy combination in the treatment of neonatal hyperbilirubinemia.
OBJECTIVE
To determine the value of oral agar in the treatment of neonatal hyperbilirubinemia and to compare it with two other treatment modalities: phototherapy alone and phototherapy plus oral agar.


METHODS
Two hundred eight jaundiced full-term newborns were divided into four groups. They were given either phototherapy alone, phototherapy plus oral agar, oral agar alone, or no treatment (control group). The changes in the serum bilirubin values were determined and the results were compared statistically, mainly using analysis of variance.


RESULTS
In all three therapy groups, the time required to reduce the bilirubin level to either 15 mg/dL or to 10 mg/dL was significantly shorter than that required by the control group. Although oral agar was found to be as effective as phototherapy, the most significant decrease in bilirubin level was in the combination group.


CONCLUSIONS
The efficacy of phototherapy in decreasing the serum bilirubin level in neonatal hyperbilirubinemia can be augmented with the use of oral agar. Oral agar can also be used as a single agent for the treatment of neonatal hyperbilirubinemia, since it is as effective as phototherapy.
Caglayan
S
S
Department of Pediatrics, Ege University, Izmir, Turkey.
Candemir
H
H
Aksit
S
S
Kansoy
S
S
Asik
S
S
Yaprak
I
I
D000284:Administration, Oral; D000362:Agar / Q000008:administration & dosage / Q000627:therapeutic use*; D000704:Analysis of Variance; D003131:Combined Modality Therapy; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000188:drug therapy / Q000628:therapy*; D010789:Phototherapy; D011446:Prospective Studies; D016896:Treatment Outcome
D000362:Agar