A structured compartmental model for drug kinetics.
A compartmental model with a structure that describes drug kinetics by incorporating the ideas of diffusion and gamma distributed clearance times is proposed. The equations describing this model may be solved by elementary numerical techniques, and the model is shown to fit a data set describing renal gentamicin concentrations, better than a simple power-function model.
Department of Mathematics, University of Queensland, Brisbane, Australia.
M J
MJ
Faddy
D000818:Animals; D001699:Biometry; D005839:Gentamicins / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D008954:Models, Biological; D015233:Models, Statistical; D010599:Pharmacokinetics; D012756:Sheep
D005839:Gentamicins