Non-steroidal anti-inflammatory drugs.
Pre-clinical studies suggest that, whilst NSAIDs have similar anti-inflammatory efficacy, the potential for producing side effects varies widely between members of this class of therapeutic agents. The ways in which NSAIDs produce one of their most serious side effects, gastrointestinal damage, are outlined and consideration is given to ways of minimizing such problems.
SmithKline Beecham Pharmaceuticals, Brentford, Middlesex.
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004363:Drug Utilization; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D012216:Rheumatic Diseases / Q000188:drug therapy*; D013810:Therapeutic Equivalency
D000894:Anti-Inflammatory Agents, Non-Steroidal