Midtrimester induction of abortion: comparison of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2 alpha.
The efficacy of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2 alpha for pregnancy termination in midtrimester was compared. A retrospective review of pregnancy termination in midtrimester using intra-amniotic instillation of 40 mg of prostaglandin F2 alpha (n = 133) or extraovular instillation of prostaglandin E2 at a rate of 500 micrograms/hour (n = 81) was performed. Both groups had a similar mean induction-to-abortion interval (19.5 +/- 19.9 and 20.9 +/- 18.2 hours for extraovular PGE2 and intra-amniotic PGF2 alpha, respectively) and a similar success rate of abortion within the first 24 hours of initial treatment (84.0% for extraovular PGE2 and 76.7% for intra-amniotic PGF2 alpha). The two groups had a similar and low (9.8%) incidence of complications. It is concluded that either of the methods used in the study (i.e. extraovular PGE2 or intra-amniotic PGF2 alpha) can be used safely and effectively for pregnancy termination in midtrimester.
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
S
S
Lurie
Z
Z
Katz
V
V
Insler
D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D000650:Amnion; D016009:Chi-Square Distribution; D003475:Curettage; D015237:Dinoprost / Q000008:administration & dosage / Q000009:adverse effects; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005313:Fetal Death / Q000601:surgery; D006801:Humans; D007322:Instillation, Drug; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D016896:Treatment Outcome
D015237:Dinoprost; D015232:Dinoprostone