[A case report of graft-versus-host disease caused by using stored blood after aortic valve replacement].
A 61-year-old man underwent aortic valve replacement and received transfusion of 8 units of stored blood. Erythema appeared on the entire body the 12th day after operation, and was followed by high fever, elevation of liver enzymes, progressive pancytopenia, aplastic bone marrow and diarrhea. He died due to septic shock on the 19th postoperative day. Skin biopsy showed the typical features observed in graft-versus-host disease (GVHD). Based on the clinical course, skin and bone marrow biopsy, we diagnosed as post-transfusion GVHD. Therefore, even when stored blood or stored red blood cells are used, these should be irradiated and transfused through the leukocyte removal filter.
Second Department of Surgery, Tottori University Medical School, Japan.
Y
Y
Hara
K
K
Morimoto
Y
Y
Nakamura
S
S
Sasaki
H
H
Kuroda
T
T
Mori
K
K
Tanaka
K
K
Nishikawa
D001021:Aortic Valve / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000601:surgery; D001793:Blood Preservation; D006086:Graft vs Host Disease / Q000209:etiology* / Q000517:prevention & control; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D065227:Transfusion Reaction