Cardiorespiratory effects of combined midazolam and butorphanol in isoflurane-anesthetized cats.
The cardiorespiratory effects of midazolam (0.1 mg/kg) and butorphanol (0.4 mg/kg) were evaluated in seven cats. Cats were induced in a chamber, removed and intubated, and maintained with isoflurane in 100% oxygen. Cardiorespiratory data were recorded before and 3, 10, 20, 30, 40, 50, and 60 minutes after intravenous injection of midazolam-butorphanol. Heart rate, mean arterial pressure, and respiration rate were significantly (p < .05) decreased below baseline at various times throughout the study. Tidal volume and minute ventilation were unchanged. End-tidal carbon dioxide was significantly (p < .05) increased above baseline for 30 minutes. Midazolam-butorphanol administered intravenously induced significant alterations in several cardiorespiratory parameters in isoflurane-anesthetized cats.
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211.
M E
ME
Gross
J A
JA
Smith
W J
WJ
Tranquilli
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D002077:Butorphanol / Q000494:pharmacology*; D002415:Cats / Q000502:physiology* / Q000601:surgery; D006321:Heart / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology; D008874:Midazolam / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
D000759:Adjuvants, Anesthesia; D007530:Isoflurane; D002077:Butorphanol; D008874:Midazolam