Lipoperoxidative damage in experimental rabbits with atherosclerosis.
The extent of lipoperoxidation in experimental rabbits with atherosclerosis was determined dynamically during the experimental period of 65 days. Lipoperoxide (LPO) levels and selenium-dependent glutathions peroxidase (SeGSHPx) activities in liver, aorta, heart muscle, plasma erythrocyte (RBC) and platelet were examined on the 65th day. The results showed that the potential anti-lipoperoxidation in the atherosclerotic rabbits was decreased significantly, and the tissues were suffered from lipoperoxidative damage. It seems that there is a close relationship between lipoperoxidative damage and the development of atherosclerosis.
Research Group of Lipid Peroxidative Damage, First Military Medical University, Guangzhou.
Y
Y
Chen
M
M
Zhou
H
H
Kong
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits
D008054:Lipid Peroxides; D005979:Glutathione Peroxidase