Complementation analysis in ataxia telangiectasia: fibroblast-lymphoblastoid cell heterokaryon assay by radiation-induced chromosome aberrations.
Using radiation-induced chromosome aberrations as a marker, heterokaryons of ataxia telangiectasia formed between appropriate combinations of lymphoblastoid cell lines (LCLs) and fibroblasts representing four and two different groups, respectively, were analyzed. The results showed that complementation group 2 in the LCL series corresponds to group D in the fibroblast series.
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Brisbane, Australia.
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Kidson
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002459:Cell Fusion; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D005347:Fibroblasts; D005816:Genetic Complementation Test; D005819:Genetic Markers; D006801:Humans; D008214:Lymphocytes
D005819:Genetic Markers