Pregnancy after BMT: three case reports.
A case of successful pregnancy after BMT in a 24-year-old woman with ALL, conditioned with CY, L-asparaginase, methylprednisolone and total body irradiation (TBI) is reported. A second case of two spontaneously aborted pregnancies in a woman transplanted for ALL at the age of 29 years using CY and TBI conditioning and a third case, this time a successful pregnancy in a woman transplanted for AML at age 27 years using CY and TBI conditioning are also described. There are now 6 successful live births after TBI reports of, versus 16 following regimens in which no TBI is used. This is the first report of a successful pregnancy reported in a female transplanted when older than 25 years using any TBI-containing regimen.
Lipton
J H
JH
Department of Medicine, Princess Margaret Hospital/Ontario Cancer Institute, University of Toronto, Canada.
Derzko
C
C
Fyles
G
G
Meharchand
J
J
Messner
H A
HA
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D011184:Postoperative Period; D011247:Pregnancy; D014916:Whole-Body Irradiation