Clinical theophylline toxicity: acute and chronic.
Reliable methods for measuring serum theophylline levels have provided the clinician with a range of serum theophylline concentrations to maximize therapeutic results while minimizing potential adverse effects. Although serum theophylline levels are often quoted for diagnosing theophylline toxicity, intolerance of this agent is closely associated with clinical features that are more important than an absolute serum value. This report contrasts the two most common settings of theophylline toxicity and presents an approach to the treatment of each type.
Division of Respiratory and Environmental Medicine, University of Louisville School of Medicine, KY.
R P
RP
Byrd
P
P
Lopez
P
P
Mercer
T M
TM
Roy
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects / Q000097:blood; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000097:blood* / Q000628:therapy; D005260:Female; D006801:Humans; D008657:Metabolic Clearance Rate; D013406:Suicide, Attempted; D013806:Theophylline / Q000493:pharmacokinetics / Q000506:poisoning*
D003692:Delayed-Action Preparations; D013806:Theophylline