Oxygen radicals induce pulmonary vasoconstriction in pigs without activating plasma proteolytic cascade systems.
The effects of infusion of the oxygen radical generating system, hypoxanthine-xanthine oxidase, on pulmonary hemodynamics and plasma proteolytic systems, as the plasma kallikrein-kinin and fibrinolytic systems, were studied in pigs by infusion of xanthine oxidase into the pulmonary circulation. A marked pulmonary vasoconstriction and increase in vasculature resistance with a maximum after 25 min was observed. The effects were attenuated by indomethacin, allopurinol and catalase. During the 130-min observation time there were no signs indicating activation of either the plasma kallikrein or the plasma fibrinolytic systems.
Institute for Surgical Research, National Hospital, Oslo, Norway.
J
J
Sanderud
O D
OD
Saugstad
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D002374:Catalase / Q000494:pharmacology; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D005609:Free Radicals; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D016234:Kallikrein-Kinin System / Q000502:physiology; D008297:Male; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014969:Xanthine Oxidase / Q000494:pharmacology
D005609:Free Radicals; D007042:Hypoxanthines; D017382:Reactive Oxygen Species; D019271:Hypoxanthine; D000493:Allopurinol; D002374:Catalase; D014969:Xanthine Oxidase; D007213:Indomethacin