The role of lymphoid cells in hematopoietic regulation.
The present review has summarized evidence supporting the existence of different lymphoid subsets with opposing effects on hematopoietic cell growth (Table 1); specifically; a) growth stimulation resulting from the release of interleukins and granulocyte-macrophage colony-stimulating factor (GM-CSF) by particular subsets of lymphocytes and resting natural killer (NK) cells and b) growth inhibition resulting from the release of interferon (IFN) and tumor necrosis factor (TNF) by stimulated NK, B and lymphokine-activated killer (LAK) cells and inhibitory T lymphoid subsets. The systematic examination of the physiologic relevance of lymphoid subsets would add an important element to a more comprehensive model of hematopoietic regulation that might hold promise in future clinical applications.
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201.
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D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000502:physiology*; D007694:Killer Cells, Natural / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*