Biocompatibility of tetracalcium phosphate cement when used as a bone substitute.
We evaluated the biocompatibility of tetracalcium phosphate (4CP) cement, made of 4CP powder and 40 wt% copolymer of polyacrylic acid/itaconic acid and 10 wt% citric acid solution. Light and electron microscopic characteristics were studied 3, 10 and 30 d after implantation. Neither inflammation nor foreign-body giant cell reaction was observed in the tissue adjacent to the implanted material. After 30 d, this material was surrounded with newly formed bone. Ultrastructural examination showed that osteogenesis occurred directly on the surface of the material. These findings suggest that this 4CP cement is biocompatible and possesses osteoconductive properties.
Department of Periodontics and Endodontics, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
Y
Y
Yoshimine
A
A
Akamine
M
M
Mukai
K
K
Maeda
M
M
Matsukura
Y
Y
Kimura
T
T
Makishima
D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D008297:Male; D008854:Microscopy, Electron; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats
D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous