Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D28k.
Calbindin-D28k, a calcium-binding protein, has been identified within a subpopulation of midbrain dopaminergic (DA) neurons in rats, monkeys and humans. The neuroactive peptides CCK and neurotensin also have been found in a subpopulation of midbrain DA neurons. Using double- and triple-labeling immunocytochemical staining procedures in the rat, we now report that the midbrain DA neurons that contain the peptides also contain calbindin-D28k. Calbindin-D28k may play a role in the co-release of neuroactive peptides with dopamine from the midbrain DA neurons.
German
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Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
Liang
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D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D002766:Cholecystokinin / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008636:Mesencephalon / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D009496:Neurotensin / Q000378:metabolism; D051381:Rats; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*
C576498:CALB1 protein, human; C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D009479:Neuropeptides; D064030:S100 Calcium Binding Protein G; D009496:Neurotensin; D002766:Cholecystokinin; D004298:Dopamine