Genetics and obstructive sleep apnea syndrome: a study of human leukocyte antigen (HLA) typing.
To investigate the possible influence of genetics in subjects with obstructive sleep apnea syndrome (OSAS), HLA-A, B, C, and DR antigens were studied in 32 Japanese subjects with OSAS. The frequency of HLA-A2 antigen was markedly increased in the patients with OSAS compared with normal controls (81.3% vs 40.6%) and compared with the Japanese population (40.7%), Pc < 0.035 and Pc < 0.007, respectively. HLA-B39 was found more frequently in OSAS patients than in the Japanese population (Pc < 0.018), but not in the controls. No significant deviation was observed in the frequencies of HLA-C and DR antigens between the OSAS patients and the controls. We conclude that genetics is important in the development of OSAS.
Yoshizawa
T
T
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Akashiba
T
T
Kurashina
K
K
Otsuka
K
K
Horie
T
T
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012891:Sleep Apnea Syndromes / Q000235:genetics* / Q000276:immunology*
D006680:HLA Antigens; D006684:HLA-DR Antigens