Effects of phenolic compounds on bromobenzene-mediated hepatotoxicity in mice.
1. The hepatic protective effects of the phenolic compounds 7,8-dihydroxyflavone, morin, silymarin, caffeic acid and chlorogenic acid on bromobenzene-induced toxicity in mice were studied. 2. Morin, caffeic acid and chlorogenic acid at an oral dose of 200 mg/kg failed to influence hepatotoxicity in vivo, while 7,8-dihydroxyflavone exhibited efficacy and potency higher than those of the reference compound silymarin. 3. 7,8-Dihydroxyflavone, an antioxidant and hepatoprotective agent in vitro, decreased serum glutamate-pyruvate transaminase levels (SGPT) in a dose-related manner, and at 200 mg/kg inhibited bromobenzene-induced glutathione depletion in liver.
Departamento de Farmacología, Facultad de Farmacia, Valencia, Spain.
M
M
Payá
M L
ML
Ferrandiz
M J
MJ
Sanz
M J
MJ
Alcaraz
D000818:Animals; D001969:Bromobenzenes / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D005419:Flavonoids / Q000627:therapeutic use; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010636:Phenols / Q000627:therapeutic use*; D012838:Silymarin / Q000627:therapeutic use
D001969:Bromobenzenes; D005419:Flavonoids; D010636:Phenols; D012838:Silymarin; C032036:bromobenzene; D005978:Glutathione