The Drosophila neuralized gene encodes a C3HC4 zinc finger.
The neurogenic genes of Drosophila are required for cell-cell communication that determines the choice between neuronal and epidermal cell fate. Here we report the molecular characterization of the neurogenic gene neuralized (neu) and show that it encodes a protein containing a C3HC4 zinc finger DNA-binding motif. This motif has been previously characterized in a variety of regulatory proteins, including transcription factors, locus-specific Drosophila chromosomal proteins, and oncoproteins. These results suggest a nuclear function for neu in the cell-cell signalling process responsible for inhibiting neuronal determination.
Laboratory of Genetics, University of Wisconsin, Madison 53706.
B D
BD
Price
Z
Z
Chang
R
R
Smith
S
S
Bockheim
A
A
Laughon
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002450:Cell Communication / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics*; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D008025:Ligases; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000166:cytology; D012333:RNA, Messenger / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D044767:Ubiquitin-Protein Ligases; D016335:Zinc Fingers / Q000235:genetics*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D004247:DNA; D044767:Ubiquitin-Protein Ligases; C071006:neur protein, Drosophila; D008025:Ligases