Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats.
Inflammation was induced in the lateral prostate of castrated Wistar rats by exposure to a sc implant of estradiol-filled Silastic tubing, followed by the addition of a dihydrotestosterone implant to restore prostatic wet weight. The presence of inflammation was correlated with increased serum PRL, elevated pituitary weight, and a greater than 2-fold increase in the lateral prostate DNA concentration. The administration of bromocriptine (4 mg/kg.day) to these animals was effective in suppressing pituitary weight and hyperprolactinemia and mitigated the lateral prostate inflammatory response. Inflammation was restored in the bromocriptine-treated hormone-implanted rats by administering exogenous ovine PRL at a dose of 2 mg/kg twice a day. The results indicate that estradiol-induced inflammation in the rat lateral prostate is mediated at least in part by the release of PRL from the pituitary.
Tangbanluekal
L
L
Department of Anatomy, Physiological Sciences, and Radiology, North Carolina State University College of Veterinary Medicine, Raleigh 27606.
Robinette
C L
CL
D000818:Animals; D004247:DNA / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol; D008297:Male; D009929:Organ Size; D009994:Osmolar Concentration; D010902:Pituitary Gland / Q000473:pathology; D011388:Prolactin / Q000097:blood / Q000502:physiology*; D011467:Prostate / Q000378:metabolism; D011472:Prostatitis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D013196:Dihydrotestosterone; D004958:Estradiol; D011388:Prolactin; D004247:DNA