Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I.
Olfactory marker protein (OMP) shows olfactory neuron-specific expression in rodents. We recently reported tight linkage on mouse chromosome 7 of OMP to the shaker-1 deafness mutant, between the tyrosinase and globin loci. Here we isolate and map the human homologue. Our results show that OMP maps immediately centromeric to tyrosinase on the long arm of human chromosome 11. Genetic linkage to this region has recently been established for Usher Syndrome Type I, an autosomal recessive blindness and deafness disorder and a putative homologue of the shaker-1 mutant. OMP is thus a candidate gene for both congenital deafness defects.
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
K L
KL
Evans
J
J
Fantes
C
C
Simpson
B
B
Arveiler
W
W
Muir
J
J
Fletcher
V
V
van Heyningen
K P
KP
Steel
K A
KA
Brown
S D
SD
Brown
D000818:Animals; D001766:Blindness / Q000151:congenital / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003638:Deafness / Q000151:congenital / Q000235:genetics*; D005808:Genes, Recessive; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008126:Lod Score; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics; D014442:Monophenol Monooxygenase / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051842:Olfactory Marker Protein; D013577:Syndrome
D005819:Genetic Markers; D009419:Nerve Tissue Proteins; C497597:OMP protein, human; D051842:Olfactory Marker Protein; C497598:Omp protein, mouse; D014442:Monophenol Monooxygenase