Cardiovascular responses in persons with paraplegia to prolonged arm exercise and thermal stress.
The purpose of this study was to investigate cardiovascular responses in subjects with paraplegia (P) during prolonged upper body exercise in a hot environment. In addition, the effect of the level of the lesion on cardiovascular regulation of persons with paraplegia was studied. Four P with lesions between T2-T6 (P1), five P with T7-T8 lesions (P2), four P with lesions between T9-T12 (P3), and 10 control subjects (C) performed 45-min arm-cranking exercise at 40% of the individual peak power output, in a climatic room at 35 degrees C with a 70% relative humidity. From the 15th to the 45th min, cardiac output (Q) and oxygen uptake (VO2) remained unaltered in all subjects, except a significant decrease of Q in P1. Stroke volume (SV) decreased significantly in both P (-20%) and C (-18%) during the test. Heart rate (HR) increased in compensation for P2 (56%), P3 (65%), and C (55%), whereas HR in P1 did not increase significantly. Hemoglobin concentration changes, representing total plasma volume changes, increased significantly in P2, P3, and C but not in P1. Weight loss and sweat rate increased relative to the sensate skin area and, thus, to the level of the spinal cord lesion (P < 0.01). In conclusion, P with lesions below T6 are able to maintain a stable Q by increasing HR to compensate for the declining SV during exercise in a hot environment. P with lesions above T6 cannot fully compensate for the reduction in SV by an increase in HR, therefore, Q declines.
Department of Physiology, University of Nijmegen, The Netherlands.
M T
MT
Hopman
B
B
Oeseburg
R A
RA
Binkhorst
D000328:Adult; D000704:Analysis of Variance; D001132:Arm; D001775:Blood Circulation; D001833:Body Temperature Regulation; D002302:Cardiac Output; D002319:Cardiovascular System / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D010264:Paraplegia / Q000503:physiopathology*; D010807:Physical Endurance; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology*; D013312:Stress, Physiological; D013318:Stroke Volume; D013546:Sweating; D014666:Vasomotor System / Q000503:physiopathology; D015431:Weight Loss