Neurobehavioral methods used in neurotoxicological research.
Exposure to chemicals in the environment and workplace can have adverse effects on the nervous system. Behavioral endpoints are being used with greater frequency in the hazard identification phase of neurotoxicology risk assessment. One reason behavioral procedures are used in animal neurotoxicology studies is that they evaluate neurobiological functions known to be affected in humans exposed to neurotoxic agents, including alterations in sensory, motor, autonomic, and cognitive function. In hazard identification, behavioral tests are used in a tiered-testing context. Tests in the first tier are designed to determine the presence of neurotoxicity. Examples of first-tier behavioral tests include functional observational batteries and motor activity. Second-tier tests are used to characterize neurotoxicant-induced effects on sensory, motor, and cognitive function. Second-tier tests are usually more complex and costly to perform. Reliance on behavioral endpoints in neurotoxicology risk assessment will likely increase in the future.
Tilson
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Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D006801:Humans; D009420:Nervous System / Q000187:drug effects*; D012306:Risk; D014116:Toxicology / Q000379:methods*