Association of IgG anti-GD1a antibody with severe Guillain-Barré syndrome.
We earlier reported cases of 2 patients with severe acute Guillain-Barré syndrome (GBS) associated with high-IgG anti-GD1a antibody titer. We now have investigated the autoantibody against GD1a or GM1 in 37 GBS patients using the enzyme-linked immunosorbent assay and have found a statistically significant association between IgG anti-GD1a antibody and the severity of the disease (need of a respirator for more than 1 month and a poor functional prognosis 3 months after neurologic onset). An autopsy which showed severe GBS associated with IgG anti-GD1a antibody produced the following findings: (1) severe axonal degeneration and segmental demyelination of peripheral nerves; (2) lymphocytic infiltration; and (3) marked central chromatolysis of the lower motoneurons.
Yuki
N
N
Department of Neurology, Niigata University, Japan.
Yamada
M
M
Sato
S
S
Ohama
E
E
Kawase
Y
Y
Ikuta
F
F
Miyatake
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D005260:Female; D005677:G(M1) Ganglioside / Q000097:blood / Q000276:immunology*; D005732:Gangliosides / Q000097:blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000097:blood / Q000276:immunology* / Q000473:pathology
D000888:Antibodies, Anti-Idiotypic; D005732:Gangliosides; D007074:Immunoglobulin G; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside