The use of botulinum toxin in the treatment of adductor spasmodic dysphonia.
Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of the speech sample, indicating a reduction in the variability of pitch amongst patients. A total of 96% of patients' subjective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.
National Hospital for Neurology and Neurosurgery, London.
R
R
Whurr
M
M
Lorch
H
H
Fontana
G
G
Brookes
A
A
Lees
C D
CD
Marsden
D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy / Q000503:physiopathology*; D013060:Speech / Q000187:drug effects; D014827:Vocal Cords / Q000187:drug effects / Q000503:physiopathology*; D014832:Voice Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D014833:Voice Quality
D001905:Botulinum Toxins