Foamy spheroid bodies in the globus pallidus and the substantia nigra pars reticulata: an investigation on regional distribution in 56 cases without neurodegenerative diseases.
In order to clarify the sites of predilection for foamy spheroid bodies (FSBs) their regional distribution was studied in 56 persons (30-98 years) without neurodegenerative diseases. Variable amounts of FSBs were observed in approximately 30% of cases and favoured the rostro-ventral parts of the globus pallidus (GP), including the ventral pallidum, and/or the substantia nigra pars reticulata (SNr). The results strongly suggest that FSBs develop during aging and are a hitherto undescribed pathological hallmark for degeneration of the GP and the SNr.
Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan.
N
N
Arai
T
T
Mizutani
Y
Y
Morimatsu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005917:Globus Pallidus / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008830:Microbodies / Q000473:pathology*; D008875:Middle Aged; D013378:Substantia Nigra / Q000648:ultrastructure*