Serial measurements of neuropeptide Y in plasma for monitoring neuroblastoma in children.
Neuropeptide Y (NPY) was studied as a marker for neuroblastoma in 12 children. All but one patient with neuroblastoma had elevated plasma NPY concentrations at diagnosis. During treatment NPY values returned to normal in 9 of 12 children. All three children without normalization of plasma NPY values died; two of them had a relapse and the third died of toxic effects. Plasma NPY appears to be a sensitive marker of neuroblastoma.
University Children's Hospitals, Essen, Germany.
W
W
Rascher
B
B
Kremens
S
S
Wagner
F
F
Feth
D H
DH
Hunneman
R E
RE
Lang
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D009478:Neuropeptide Y / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood; D014642:Vanilmandelic Acid / Q000097:blood
D014408:Biomarkers, Tumor; D009478:Neuropeptide Y; D014642:Vanilmandelic Acid; D010751:Phosphopyruvate Hydratase; D006719:Homovanillic Acid