Lupoid sclerosis with antiphospholipid and antimyelin antibodies.
Lupoid sclerosis is a rare syndrome associating clinical symptoms of multiple sclerosis (MS), positive false tests for syphilis and positive tests for antinuclear and anticardiolipin antibodies. In a patient with lupoid sclerosis, antimyelin antibodies were detected by indirect immunofluorescence on human sciatic nerve sections. These antibodies were not found in the serum of control patients with MS nor in sera of patients with antiphospholipid autoantibodies and focal ischemic neurologic disease. The presence of such antimyelin antibodies may contribute to the underlying physiopathological mechanism of this syndrome.
Department of Immunohematology, Hôpital Saint Louis, Paris, France.
S
S
Marullo
J P
JP
Clauvel
L
L
Intrator
F
F
Danon
J C
JC
Brouet
E
E
Oksenhendler
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology*; D012584:Sciatic Nerve / Q000276:immunology; D013577:Syndrome
D000906:Antibodies; D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid