Hyperaemic response in the skin microcirculation of patients with chronic venous insufficiency.
The capacity of the microcirculation in the liposclerotic skin of patients with chronic venous insufficiency to vasodilate in response to pilocarpine electrophoresis was assessed using laser Doppler fluxmetry. Pilocarpine induces vasodilation by direct action on capillaries; other methods of vasodilatation, such as heating of the skin, act by a number of pathways including a neurogenic one. Thirty patients with lipodermatosclerosis and chronic venous insufficiency and 20 control subjects were studied. There was no difference in peak vasodilatation following pilocarpine electrophoresis in the two groups. The median (interquartile range) peak flux in patients was 665 (382-1025) units and in controls 765 (452-975) units (95 per cent confidence interval of difference--270 to 150 units, P = 0.5). This suggests that the capillaries in the liposclerotic skin of patients with chronic venous insufficiency have a normal capacity to vasodilate.
University College and Middlesex School of Medicine, London, UK.
S K
SK
Shami
T R
TR
Cheatle
S J
SJ
Chittenden
J H
JH
Scurr
P D
PD
Coleridge Smith
D000368:Aged; D002908:Chronic Disease; D004586:Electrophoresis; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000209:etiology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D010862:Pilocarpine; D012594:Scleroderma, Localized / Q000503:physiopathology; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation / Q000187:drug effects; D014689:Venous Insufficiency / Q000150:complications* / Q000503:physiopathology
D010862:Pilocarpine