Linkage mapping detects two secondary microdeletions in cell hybrid HHW1064, used to isolate DNA probes from within 5q11.2-->q13.3.
The somatic cell hybrid HHW1064 contains a single human chromosome 5 with an interstitial deletion for 5q11.2-->q13.3. Twenty human clones were isolated by Alu-PCR differential hybridization. Mapping these clones indicates that HHW1064 contains two additional secondary microdeletions.
Bernard
L E
LE
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
McPherson
J D
JD
Wasmuth
J J
JJ
Kreklywich
C N
CN
Brzustowicz
L M
LM
Wood
S
S
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D005260:Female; D017353:Gene Deletion; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D008297:Male; D016133:Polymerase Chain Reaction
D005819:Genetic Markers