A nonpeptidyl growth hormone secretagogue.
A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-([2'-(1H-tetrazol-5 -yl) (1,1'-biphenyl)-4-yl]methyl)-1H-1-benzazepin-3(R)-yl)-butanamid e (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an alternative signal transduction pathway. The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). L-692,429 is an example of a nonpeptidyl specific secretagogue for growth hormone.
Smith
R G
RG
Department of Basic Animal Science Research, Merck Research Laboratories, Rahway, NJ 07065.
Cheng
K
K
Schoen
W R
WR
Pong
S S
SS
Hickey
G
G
Jacks
T
T
Butler
B
B
Chan
W W
WW
Chaung
L Y
LY
Judith
F
F
D000595:Amino Acid Sequence; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D013006:Growth Hormone / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D015290:Second Messenger Systems / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000494:pharmacology*
D001552:Benzazepines; D009842:Oligopeptides; D013777:Tetrazoles; C081455:L 692429; C041048:growth hormone releasing hexapeptide; D013006:Growth Hormone