[Cytokines in uveal melanoma. Original title: uveal melanoma cytokines].
Cytokines may be important in both the pathophysiology an ocular morbidity associated with treated and untreated uveal melanomas. In this study we used message amplification phenotyping to identify cytokines present in uveal melanoma samples. A number of cytokines were noted that have been associated with tumor progression, neovascularization, and inflammation in other malignancies. Interferongamma was commonly found in spindle cell tumors. Only one of 16 tumors had detectable levels of TNF-alpha and this occurred in one of two patients who developed metastatic disease.
Abteilung für okulare Onkologie der Augenklinik, University of California, San Francisco.
R S
RS
Filer
J C
JC
Song
D H
DH
Char
S
S
Kaleta-Michaels
D016207:Cytokines / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014602:Uvea / Q000473:pathology; D014604:Uveal Neoplasms / Q000235:genetics* / Q000473:pathology
D016207:Cytokines; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
Zytokine in Uveamelanomen. Originaltitel: Uveal Melanoma Cytokines.