alpha-Latrotoxin receptor. Implications in nerve terminal function.
alpha-Latrotoxin is a potent stimulator of neurotransmitter release from nerve terminals. High affinity membrane alpha-latrotoxin receptor was purified in an active binding form. It is a membrane glycoprotein (M(r) 160,000-220,000) which may be complexed to a smaller polypeptide (M(r) 29,000). The structure of the receptor protein suggests that it may be a synapse-specific cell recognition molecule. Intracellularly, the alpha-latrotoxin receptor interacts with synaptotagmin, a calcium- and phospholipid-binding protein specifically localized in the synaptic vesicle membrane. This interaction may be important for targeting of synaptic vesicles to presynaptic release sites.
Research Center of Molecular Diagnostics and Therapy, Moscow, Russian Federation.
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Petrenko
D000818:Animals; D002135:Calcium-Binding Proteins; D003001:Cloning, Molecular; D008562:Membrane Glycoproteins / Q000502:physiology; D015394:Molecular Structure; D009411:Nerve Endings / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D011950:Receptors, Cholinergic / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018000:Receptors, Peptide; D050857:Synaptotagmins
D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011950:Receptors, Cholinergic; D018000:Receptors, Peptide; C034800:alpha-latrotoxin receptor; D050857:Synaptotagmins