Hyperinsulinemia as a factor modifying sensitivity of endometrial carcinoma to hormonal influences.
In 22 patients with endometrial carcinoma, Stage I-III (mean age 57.8 years) with obesity, initial and reactive hyperinsulinemia (during glucose load) was revealed. Significant correlations between values of "peak" and field-square of the insulin secretion curve and cytoplasmatic receptors to Estradiol and Progesterone in the tumor were found. In a group of the patients with high values of reactive hyperinsulinemia significantly larger amounts of steroid hormone receptors in the tumor were determined as compared to the group of the patients who had low insulinemia values. On considering these data a possible conclusion was reached as to the modifying influence of hyperinsulinemia on sensitivity of endometrial carcinoma to hormone receptor synthesis in the tumor by insulin.
Petrov Research Institute of Oncology, St. Petersburg, Russia.
A S
AS
Vishnevsky
Bobrov JuF
E V
EV
Tsyrlina
V M
VM
Dilman
D016889:Endometrial Neoplasms / Q000209:etiology* / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D006946:Hyperinsulinism / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology* / Q000378:metabolism; D009765:Obesity / Q000150:complications; D011959:Receptors, Estradiol / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone