Increased lung injury in pulmonary hypertensive patients during open heart operations.
To investigate lung injury in adult open heart operations during extracorporeal circulation, we measured plasma chemiluminescence levels. Nineteen patients were divided into two groups depending on preoperative pulmonary artery pressure: a pulmonary hypertension group (n = 11) and a control group (n = 8). Plasma samples were taken simultaneously from arterial and central venous lines at six different points during and early after operation. Arteriovenous difference of chemiluminescence (counts/10 seconds) increased significantly only in the pulmonary hypertension group (from -19.1 +/- 8.3 at the end of cross-clamping to 23.7 +/- 12.4 at the end of bypass; p < 0.01). There was a positive correlation between peak values of arterial plasma chemiluminescence and postoperative respiratory index in the pulmonary hypertension group (p < 0.05). In addition, during the first 12 hours postoperatively, arteriovenous difference of chemiluminescence in the pulmonary hypertension group changed significantly from negative to positive values (p < 0.05). These data suggest that free radical activity (detected by chemiluminescence) was deeply involved in lung injury during and also early after open heart operations, especially in pulmonary hypertensive patients.
Komai
H
H
Department of Cardiovascular Surgery and Clinical Laboratory, National Cardiovascular Center, Osaka, Japan.
Yamamoto
F
F
Tanaka
K
K
Murashita
T
T
Shibata
T
T
Sakai
H
H
Kawashima
Y
Y
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D005260:Female; D005609:Free Radicals / Q000097:blood; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000503:physiopathology*; D007958:Leukocyte Count; D008163:Luminescent Measurements; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011651:Pulmonary Artery / Q000503:physiopathology; D011659:Pulmonary Gas Exchange; D012119:Respiration; D013997:Time Factors
D005609:Free Radicals; D002245:Carbon Dioxide; D010100:Oxygen