Transcriptional regulation of multigene loci: multilevel control.
Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.
Dillon
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N
Laboratory of Gene Structure and Expression, MRC National Institute for Medical Research, Mill Hill, London, UK.
Grosveld
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F
D000818:Animals; D005786:Gene Expression Regulation; D005809:Genes, Regulator / Q000502:physiology; D006801:Humans; D051379:Mice; D005810:Multigene Family; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic