[A study on markers of bone metabolism in patients with non hypercalciuric calcium stone--measurement of gamma-carboxyglutamic acid and hydroxyproline].
Thirty-one patients (26 male and 5 female patients) of non-hypercalciuric Ca stone formers were studied concerning their bone metabolism. We measured plasma free gamma-carboxyglutamic acid, plasma hydroxyproline, urinary free gamma-carboxyglutamic acid and urinary hydroxyproline as markers of bone metabolism. Plasma free gamma-carboxyglutamic acid level showed significantly higher in stone formers than normal controls (1.01 +/- 0.37 nmol/ml vs 0.39 +/- 0.13 nmol/ml). But no significant difference were observed in plasma hydroxyproline level (1.99 +/- 0.73 micrograms/ml vs 2.27 +/- 0.92 micrograms/ml), urinary free gamma-carboxyglutamic acid (52.0 +/- 17.6 nmol/mg.Cr vs 45.7 +/- 9.8 nmol/mg.Cr), and urinary hydroxyproline (3.87 +/- 2.02 micrograms/mg.Cr vs 3.33 +/- 1.63 micrograms/mg.Cr). In conclusion, these results suggest that abnormality of bone metabolism may be not a primary event in causing stone formation in these patients.
Department of Urology, Matsusaka Chuo Hospital.
Y
Y
Maruyama
N
N
Hirata
H
H
Yamada
K
K
Sasaki
Y
Y
Motomiya
Y
Y
Hirao
E
E
Okajima
D015055:1-Carboxyglutamic Acid / Q000032:analysis*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D014545:Urinary Calculi / Q000737:chemistry / Q000378:metabolism*
D015415:Biomarkers; D015055:1-Carboxyglutamic Acid; D006909:Hydroxyproline; D002118:Calcium