Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.
The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.
Rocca
M
M
Department of Experimental Surgery, Istituto di Ricerca Codivilla-Putti I.O.R., Bologna.
Capelli
S
S
Fini
M
M
Maltarello
M C
MC
Veronese
F M
FM
Caliceti
P
P
Giardino
R
R
D000818:Animals; D003131:Combined Modality Therapy; D005263:Femoral Artery / Q000601:surgery; D006614:Hindlimb / Q000098:blood supply; D007511:Ischemia / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008854:Microscopy, Electron; D008866:Microsurgery; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*
D017382:Reactive Oxygen Species; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D013482:Superoxide Dismutase