Influence of chronic intoxication with selenium on collagen and elastin content in tissues of rat.
Rats were intoxicated with sodium selenite (0.3 mg/kg body wt.) for 10 weeks. An increase in total collagen content in skin and a decrease in the lungs, liver and kidneys were observed. Enhanced serum and urine levels of collagen metabolites were found. Elastin content was shown to be increased in the lung, liver, heart muscle and kidney of selenium-intoxicated rats.
Fourth Department of Internal Medicine, Silesian School of Medicine, Sosnowiec, Poland.
E J
EJ
Kucharz
K
K
Olczyk
D000818:Animals; D003094:Collagen / Q000187:drug effects* / Q000378:metabolism; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D004549:Elastin / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000506:poisoning*; D012995:Solubility
D003094:Collagen; D004549:Elastin; D012643:Selenium