The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing.
Autogeneic cancellous bone graft has been recommended as a vehicle for local antibiotic delivery. Its effect on graft incorporation, however, is unknown. The healing of defects grafted with tobramycin-impregnated cancellous bone were compared with those grafted with cancellous bone alone. Plane roentgenographs, microradiographs, bone density analyses, histologic examination, and biomechanical testing were performed on specimens throughout the course of healing. The presence of large concentrations of local tobramycin does not appear to affect the normal healing characteristics of cancellous bone graft.
Lindsey
R W
RW
Baylor College of Medicine, Department of Orthopaedic Surgery, Houston, TX 77030.
Probe
R
R
Miclau
T
T
Alexander
J W
JW
Perren
S M
SM
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000473:pathology; D004285:Dogs; D016503:Drug Delivery Systems; D005269:Femur / Q000473:pathology / Q000601:surgery; D008852:Microradiography; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D014031:Tobramycin