Paraneoplastic cerebellar degeneration and limbic encephalitis in a patient with adenocarcinoma of the colon.
The rare association of two neurological paraneoplastic syndromes, paraneoplastic cerebellar degeneration and limbic encephalitis occurred in a 55 year old woman with a microscopic adenocarcinoma in a colonic polyp. Complete removal of the tumour by polypectomy brought about a favourable recovery from limbic encephalitis but the cerebellar ataxia remained. High titres of antineuronal nuclear antibody resembling anti-Hu were demonstrated in serum by immunohistochemistry using rat brain as a substrate. The antibody identified a protein band of 41 kDa on a Western immunoblot.
Tsukamoto
T
T
Department of Neurology, Fukushima Medical College, Japan.
Mochizuki
R
R
Mochizuki
H
H
Noguchi
M
M
Kayama
H
H
Hiwatashi
M
M
Yamamoto
T
T
D000230:Adenocarcinoma / Q000150:complications*; D015153:Blotting, Western; D001921:Brain / Q000473:pathology; D002524:Cerebellar Ataxia / Q000150:complications* / Q000378:metabolism; D003110:Colonic Neoplasms / Q000150:complications*; D004660:Encephalitis / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008032:Limbic System / Q000737:chemistry / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000378:metabolism