Interaction of ibuprofen with early chick embryogenesis.
The effects of ibuprofen (1) on the morphogenetic systems of the chick embryo were studied by means of the CHEST (Chick Embryotoxicity Screening Test). The subgerminal administration of doses of 0.03 mg 1 and larger ones induced a growth retardation of the caudal morphogenetic system (CMS). The administration of single effective doses of 1 subgerminally on the 2nd d and intraamniotically on the 3rd and 4th d of embryogenesis verified the beginning of the direct embryotoxicity range between doses of 0.003 to 0.03 mg/embryo. It presents in the theoretical extrapolation for mammals including man the dose limits between 10 and 100 mg.kg-1 of maternal weight. Embryotoxic manifestations (particularly embryolethality) were induced predominantly by the highest dose only. The developmental defects of the face, heart, brain, and the reduction limb defects were very rare.
Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
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Kosar
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D002642:Chick Embryo; D004622:Embryo, Mammalian / Q000187:drug effects; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D007052:Ibuprofen / Q000633:toxicity*
D007052:Ibuprofen