Long-term growth following neonatal anatomic repair of transposition of the great arteries.
Despite generally normal prenatal growth, surviving infants with transposition of the great arteries (TGA) frequently develop severe and progressive growth impairment which is not always fully reversed by elective atrial repair within the first year of life. This study was undertaken to determine the effect of neonatal anatomic repair of TGA on long-term growth. Twenty-three children with uncomplicated TGA were followed for a mean of 60 (12-90) months after anatomic repair at a mean age of 11 (1-40) days. Standardized measurements of weight, height, and head circumference for both patients and normal siblings were expressed as percentiles as well as in Z scores (in standard deviations from the mean for age and sex) based on internationally recognized standards. At latest follow-up, 22 (96%) of the patients were above the 3rd percentile for weight and 21 (91%) for both height and head circumference, with 13 (57%), 11 (48%), and 13 (57%) above the 50th percentile for each respective parameter. The mean Z scores (+/- SD) for weight, height, and head circumference for the patient group were -0.1 +/- 1.2, -0.2 +/- 1.3, and -0.1 +/- 1.1, respectively, and did not differ significantly from those of the reference population (p > 0.05 for each comparison). Paired comparisons of mean Z scores for each growth parameter with those of 35 normal siblings demonstrated no significant difference for weight or height and a small but significant difference for head circumference. Age at surgical repair (within the first 6 weeks of life), duration of follow-up and the development of moderate supravalvar pulmonary stenosis were not statistically related to long-term growth.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Paediatric Cardiology, Harefield Hospital, Middlesex, United Kingdom.
J W
JW
Swan
R G
RG
Weintraub
R
R
Radley-Smith
M
M
Yacoub
D001724:Birth Weight; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012886:Skull / Q000033:anatomy & histology / Q000254:growth & development; D014188:Transposition of Great Vessels / Q000503:physiopathology* / Q000601:surgery*; D016276:Ventricular Function / Q000502:physiology