[Iminium compounds against bacteria and fungi. 29. 3-Alkoxymethyl-1-ethyl-, 3-alkylthiomethyl-1-ethyl-, 3-alkoxymethyl-1-butyl-, and 3-alkylthiomethyl-1-butylbenzimidazolium chloride].
Syntheses and antimicrobial activity of 3-alkoxymethyl-1-ethyl-, 3-alkylthiomethyl-1-ethyl-, 3-alkoxymethyl-1-butyl-, and 3-alkylthiomethyl-1-butylbenzimidazolium chlorides are described. The compounds were obtained by reaction of 1-ethyl- or 1-butylbenzimidazole with chloromethylalkyl ethers or chloromethylalkyl sulfide. Antibacterial properties were tested on 13 strains of bacteria and fungi. 3-Dodecylthio-methyl-1-ethyl-benzimidazolium chloride exhibited the highest antibacterial activity.
Institut für Chemische Technologie der Technischen Universität, Poznań, Polen.
J
J
Pernak
A
A
Skrzypczak
L
L
Michalak
J
J
Jedraszczyk
J
J
Krysiński
M
M
Kazmierczak
B
B
Mrówczyński
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001562:Benzimidazoles
Iminiumverbindungen gegen Bakterien und Pilze, 29. Mitt.: 3-Alkoxymethyl-1-ethyl-, 3-Alkylthiomethyl-1-ethyl-, 3-Alkoxymethyl-1-butyl- und 3-Alkylthiomethyl-1-butylbenzimidazolium-chloride.