Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens.
We report here the first orthotopic transplant model for human ovarian cancer. Histologically-intact patient specimens of ovarian cancer were transplanted by microsurgical techniques under the capsule of the nude mouse ovary. The human tumors grew locally and gave rise to a patient-like metastatic pattern including the parietal peritoneum, colon, omentum, and ascites. The orthotopic model described here should be useful for evaluating new therapeutics and diagnostics for ovarian cancer.
AntiCancer, Inc., San Diego, CA 92110.
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Hoffman
D000818:Animals; D003110:Colonic Neoplasms / Q000556:secondary; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D016513:Mice, SCID; D009362:Neoplasm Metastasis / Q000473:pathology*; D009368:Neoplasm Transplantation; D009852:Omentum; D010051:Ovarian Neoplasms / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000556:secondary; D014183:Transplantation, Heterologous