The treatment of neonatal meningitis due to gram-negative bacilli with ciprofloxacin: evidence of satisfactory penetration into the cerebrospinal fluid.
We describe two cases of neonatal meningitis due to Gram-negative bacilli treated successfully with ciprofloxacin. Examination of serial samples of cerebrospinal fluid indicated the effect of meningeal inflammation on penetration of this drug into the CSF.
Department of Paediatrics, Institut Médical Evangélique, Kimpese, Zaïre.
S D
SD
Green
F
F
Ilunga
J S
JS
Cheesbrough
G S
GS
Tillotson
M
M
Hichens
D
D
Felmingham
D002939:Ciprofloxacin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D005417:Flavobacterium / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D002939:Ciprofloxacin