[The effect of ionizing radiation on the resistance of rat pancreatic beta cells to streptozotocin].
The effect of subliminal streptozotocin doses of rat pancreas cells was studied 1 and 3 months after 1-Gy gamma irradiation. Streptozotocin injected to irradiated animals caused a drastic decrease in beta-cell function which was manifested by hyperglycemia and less intensive secretion and lesser content of insulin in isolated pancreatic islands, as compared to control.
G G
GG
Gatsko
S I
SI
Brilevskaia
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000528:radiation effects; D005720:Gamma Rays; D007328:Insulin / Q000378:metabolism / Q000528:radiation effects; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D013997:Time Factors
D001786:Blood Glucose; D003037:Cobalt Radioisotopes; D007328:Insulin; D013311:Streptozocin
Vliianie ioniziruiushchego izlucheniia na ustoĭchivost' beta-kletok podzheludochnoĭ zhelezy krys k streptozototsinu.