[Antimicrobial prophylaxis in urethrocystoscopy. Comparative study].
Instrumentation of lower urinary tract is a predisposing factor for the development of urinary infection. Incidence of infective complications following urethrocystoscopy has been evaluated in a multicenter, prospective, comparative and randomized study in 2,284 patients, who had a previous negative urine culture. Patients were randomized into two groups: one to be used as control and the other one to received antimicrobial prophylaxis prior to instrumentation (ceftriazone, 1 gr intramuscular). Clinical and microbiological responses were evaluated at 48-72 hours and 4 weeks after cystoscopy. Symptomatic bacteriuria was observed in 10.2% of patients in the control group and in 2.5% in the prophylaxis group (p < 0.000); asymptomatic bacteriuria in 3.02% and 1.52% (p > 0.05) and irritative syndrome with sterile urine in 2.93% and 2.60% (p > 0.05), respectively. Thus, the use of prophylaxis reduced the incidence of infective complications in these patients.
Servicio de Urología, Hospital La Fe, Valencia.
J F
JF
Jiménez Cruz
S
S
Sanz Chinesta
G
G
Otero
R
R
Díaz González
F
F
Alvarez Ruiz
N
N
Flores
J
J
Virseda
L A
LA
Rioja
A
A
Zuluaga
M
M
Tallada
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D001437:Bacteriuria / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002443:Ceftriaxone / Q000627:therapeutic use*; D003558:Cystoscopy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D012737:Sex Factors; D014521:Urethra; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*
D002443:Ceftriaxone
Profilaxis antimicrobiana en uretrocistoscopias. Estudio comparativo.