Dose-dependent genotoxic effect of pan masala and areca nut in the Salmonella typhimurium assay.
Aqueous extracts of different brands of pan masala and scented supari were tested for mutagenicity by the Salmonella typhimurium assay using tester strains TA98 and TA100. These extracts were found to be mutagenic to both tester strains. The mutagenic effects of pan masala and scented supari extracts were similar to that produced by areca nut extract. The addition of 500 ppm saccharin to the supari extracts did not alter the mutagenic response.
National Institute of Nutrition, Jamai-Osmania, Hyderabad, India.
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D001114:Areca; D004305:Dose-Response Relationship, Drug; D007194:India; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009754:Nuts / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D009153:Mutagens; D010936:Plant Extracts