Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation.
We report that, in human skin, exposure to equally erythemogenic doses of UVA, UVB, and UVC increases immunocytochemically detected p53 in a wavelength-specific pattern. UVC produced immunostaining confined to the upper epidermis. With UVB, staining was seen throughout the epidermis, whereas with UVA staining predominated in the basal layer. The results with UVB and UVC are understandable on the basis of their known differences in penetration, whereas those with UVA are not. This suggests that within one cell type the pattern of p53 response to UV radiation is wavelength dependent.
Department of Dermatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, United Kingdom.
C
C
Campbell
A G
AG
Quinn
B
B
Angus
P M
PM
Farr
J L
JL
Rees
D000328:Adult; D015870:Gene Expression / Q000528:radiation effects*; D016158:Genes, p53 / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000737:chemistry / Q000528:radiation effects*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014466:Ultraviolet Rays / Q000145:classification
D016159:Tumor Suppressor Protein p53