Predictors of antidepressant response.
The development of new pharmacological agents has dramatically improved the treatment of major depressive disorders. But the question of whether there are reliable predictors of response to a particular agent or class of agent remains to be answered completely. The author provides an overview of current understanding of antidepressant response prediction in terms of three sources of variance: clinical variables, biological variables, and pharmacological response. He also notes evidence of the effectiveness of two nonpharmacological treatments, sleep deprivation therapy and light therapy.
Goodwin
F K
FK
National Institute of Mental Health, Rockville, MD 20857.
D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D010349:Patient Compliance / Q000523:psychology; D010555:Personality Inventory; D011379:Prognosis
D000928:Antidepressive Agents