A phase I study of ifosfamide with Mesna given daily for 3 consecutive days to children with malignant solid tumors.
BACKGROUND
The authors conducted a Phase I dose escalation trial of ifosfamide given daily for 3 consecutive days to 29 children with malignant solid tumors. Twenty-eight of these children had received prior chemotherapy.


METHODS
Patients were assigned to dosage cohorts separately on the basis of prior exposure to the platinum alkylating agents cisplatin or carboplatin (n = 20) or the absence of such exposure (n = 9). At least three patients in each category were treated at a starting dosage of 2133 mg/m2/d for 3 days. This dosage represented 80% of the total dose delivered in the prior study of ifosfamide given daily over 5 days with dosage escalation of 20% in subsequent cohorts.


RESULTS
Myelosuppression was dose-limiting at the second dosage level (2560 mg/m2/d) for patients previously treated with platinum and at the third dosage level (3072 mg/m2/d) for those not previously treated with platinum. Dose-limiting neurotoxicity was seen at 2560 mg/m2/d for the former group, but was not encountered in the latter group.


CONCLUSIONS
Delivery of ifosfamide daily for 3 days is feasible and safe at recommended dosages of 2133 mg/m2/d for children with prior exposure to platinum and 3000 mg/m2/d for those without prior exposure.
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
C B
CB
Pratt
W H
WH
Meyer
E C
EC
Douglass
L
L
Bowman
J
J
Wilimas
J
J
Ochs
N
N
Marina
L
L
Avery
E I
EI
Thompson
D000293:Adolescent; D000328:Adult; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D008297:Male; D015080:Mesna / Q000008:administration & dosage / Q000009:adverse effects; D009369:Neoplasms / Q000188:drug therapy*
D016190:Carboplatin; D015080:Mesna; D002945:Cisplatin; D007069:Ifosfamide