Pharmacokinetics of obidoxime in organophosphate poisoning associated with renal failure.
Obidoxime is an oxime used in several countries as an antidote in organophosphate intoxication. Its pharmacokinetics were studied in a 20 year-old female with severe and complicated methamidophos intoxication. Obidoxime elimination half life was 6.9 h, volume of distribution 0.845 L/kg, total body clearance 85.4 mL/min, and renal clearance 69 mL/min (creatinine clearance 54 mL/min). Eighty percent of the dose was excreted in the urine over 5 h. Possible reasons for the different pharmacokinetic values as compared with values previously reported in healthy volunteers are discussed. Obidoxime dose should be adjusted according to renal function. More studies are needed to establish the therapeutic window of obidoxime in patients with organophosphate intoxication.
Israel Poison Information Center, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Y
Y
Bentur
I
I
Nutenko
A
A
Tsipiniuk
B
B
Raikhlin-Eisenkraft
U
U
Taitelman
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy; D000328:Adult; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007306:Insecticides / Q000506:poisoning*; D008657:Metabolic Clearance Rate; D009768:Obidoxime Chloride / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D013406:Suicide, Attempted
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D009768:Obidoxime Chloride; C014655:methamidophos