[Lipid metabolism in daunomycin-induced nephrotic rats (Part 6)].
Lipid metabolism in tissues and HDL were examined in daunomycin-induced nephrotic rats. 1) Daunomycin-induced nephrotic rats showed the decreased phospholipids, the increased cholesterol content in heart. Phospholipids, triglycerides and cholesterol content in brain, lung and spleen were similar in daunomycin-induced nephrotic rats and control rats. 2) Triglycerides content in hepatocytes was decreased in daunomycin-induced nephrotic rats. But, cholesterol esters content in hepatocytes was higher in daunomycin-induced nephrotic rats than control rats. 3) LCAT activity in serum was increased in daunomycin-induced nephrotic rats. 4) Apolipoproteins composition of HDL in daunomycin-induced nephrotic rats showed the increased apoA-I and the decreased apo E. These results show that the increased cholesterol esters in liver tissue are due to hepatocytes in daunomycin-induced nephrotic rats. The increased HDL cholesterol content may contribute to the increase of LCAT activity in daunomycin-induced nephrotic rats. The increase of LCAT activity in serum results in the increased apo A-I content in daunomycin-induced nephrotic rats. No direct evidence about the incorporation of HDL into liver is obtained from the present experiments and further study will be necessary to clarify this evidence.
Renal and Dialysis Unit, Hyogo College of Medicine, Nishinomiya, Japan.
S
S
Gomikawa
O
O
Inagaki
H
H
Mori
S
S
Inoue
Y
Y
Takamitsu
Y
Y
Fujita
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D003630:Daunorubicin / Q000009:adverse effects* / Q000493:pharmacokinetics; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014280:Triglycerides / Q000378:metabolism
D008076:Cholesterol, HDL; D014280:Triglycerides; D003630:Daunorubicin