Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.
Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually eliminated. Severe working and reference memory deficits were evident within the radial arm maze. Both state-dependent memory and possible situation-dependent precipitation of spontaneous seizures were suggested. The behavioral changes were considered commensurate with the multifocal pattern of thalamic, hippocampal/amygdaloid, and limbic cortical damage.
Behavioral Neuroscience Program, Laurentian University, Sudbury, Ontario, Canada.
M A
MA
Persinger
Y R
YR
Bureau
M
M
Kostakos
O
O
Peredery
H
H
Falter
D000109:Acetylcholine / Q000502:physiology; D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004357:Drug Synergism; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D008032:Limbic System / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D009336:Necrosis; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009949:Orientation / Q000187:drug effects / Q000502:physiology; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D013649:Taste / Q000187:drug effects / Q000502:physiology
D006025:Glycosaminoglycans; D010862:Pilocarpine; D008094:Lithium; D000109:Acetylcholine; D002118:Calcium