Hydrochlorothiazide-induced acute pulmonary edema.
OBJECTIVE
To describe a patient with noncardiogenic acute pulmonary edema induced by hydrochlorothiazide.


METHODS
A 70-year-old woman in generally good health, except for mild pedal edema, developed acute pulmonary edema after ingesting hydrochlorothiazide 12.5 mg for the first time.


CONCLUSIONS
This is the fifteenth reported case of noncardiogenic pulmonary edema induced by hydrochlorothiazide. The investigations by previous authors seemed to rule out an immunologic mechanism; thus, the pathogenesis of the reaction is unknown. Most of the reactions have occurred in women.


CONCLUSIONS
Noncardiogenic pulmonary edema appears to be an idiosyncratic reaction that occurs with some specificity with the thiazide diuretics. Clinicians should be aware of this potential, serious adverse reaction that occurs without warning.
Division of Allergy and Immunology, Albert Einstein College of Medicine, Flushing Hospital Medical Center, NY 11355, USA.
S R
SR
Fine
A
A
Lodha
S
S
Zoneraich
J L
JL
Mollura
D000208:Acute Disease; D000368:Aged; D004232:Diuretics; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects*; D008168:Lung / Q000000981:diagnostic imaging; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide