Crystallization and preliminary X-ray study of Agkistrodon halys blomhoffii phospholipase A2 complexed with a specific inhibitor.
Phospholipase A2 from the venom of Agkistrodon halys blomhoffii has been crystallized as a complex with a specific inhibitor, (S)-2-dodecanoyl-amino-3-hexanol-1-phosphoglycol. The complex crystals belong to the hexagonal space group, P6(1)22 (or P6(5)22), with cell dimensions of a = b = 61.13 A, and c = 173.15 A. The diffraction extends to at least 2.3 A resolution.
Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences.
K
K
Tomoo
S
S
Fujii
T
T
Ishida
M
M
Inoue
K
K
Ikeda
Y
Y
Samejima
S
S
Iwama
S
S
Katsumura
D000818:Animals; D003435:Crotalid Venoms / Q000201:enzymology*; D003460:Crystallization; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D054467:Phospholipases A2; D014965:X-Rays
D003435:Crotalid Venoms; D010741:Phospholipases A; D054467:Phospholipases A2