Monitor lyophilization with mass spectrometer gas analysis.
This paper presents a brief review of the basic issues of lyophilization and the fundamentals of quadrupole mass spectrometry. The emphasis of the paper is on the application of a quadrupole mass spectrometer as a process monitor. The details of sampling and data collection are discussed. Data taken while monitoring lyophilization is presented in conjunction with cycle optimization, end point detection and contaminant detection.
Connelly
J P
JP
NGS Division of MKS Instruments, Inc., Walpole, MA.
Welch
J V
JV
D000097:Acetonitriles / Q000032:analysis; D005612:Freeze Drying / Q000592:standards; D013058:Mass Spectrometry; D012710:Serum Albumin, Bovine; D012997:Solvents / Q000032:analysis; D013997:Time Factors; D014867:Water / Q000032:analysis
D000097:Acetonitriles; D012997:Solvents; D014867:Water; D012710:Serum Albumin, Bovine; C032159:acetonitrile