Treatment-related esophageal stricture in pediatric patients with cancer.
BACKGROUND
Intensive antineoplastic regimens have enhanced long-term survival in pediatric patients with cancer, but can result in long-term complications. Esophageal stricture formation is one such complication.


METHODS
We reviewed the experience with benign esophageal stricture in pediatric patients with cancer over the past 15 years in a major cancer center. Clinical course, along with endoscopic, radiologic, and manometric esophageal studies, was reviewed.


RESULTS
Esophageal strictures formed in five pediatric patients who were treated with radiation and/or chemotherapy. Stricture formation was associated with abnormal esophageal motility in four out of the five patients. Repeated esophageal dilation was performed from 3-50 times and resulted in stricture resolution in only 2 of the 5 patients.


CONCLUSIONS
Esophageal stricture formation in this population is rare, but is associated with long-term morbidity.
Ellenhorn
J D
JD
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Lambroza
A
A
Lindsley
K L
KL
LaQuaglia
M P
MP
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D015154:Esophageal Motility Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D004940:Esophageal Stenosis / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology*; D004941:Esophagitis / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008365:Manometry; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D010157:Palatal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D011832:Radiation Injuries / Q000209:etiology*; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000532:radiotherapy; D014134:Tracheal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy