Myocardial calcification in an extremely low birth weight infant with chronic renal failure and secondary hyperparathyroidism.
Myocardial calcification has been rarely described in premature infants after myocardial infarction and myocarditis with coxsackievirus B1. In adults and older children, metastatic myocardial calcification has been reported in chronic renal failure. We report a case of myocardial calcification in a 680-gm preterm infant after a prolonged course of renal failure complicated by secondary hyperparathyroidism. Subclinical myocardial injury was evidenced by a high serum creatine phosphokinase MB band concentration, which probably provided a susceptible substrate for the deposition of calcium crystals, because the multiplication product of serum calcium and inorganic phosphorus levels transiently exceeded 75 mg x mg/100 ml, indicating serum saturation during the course of secondary hyperparathyroidism. We report this case as an unusual complication of renal immaturity in extremely low birth weight infants and an indication of a relatively intact parathyroid glandular function in them. Hypoxia, myocardial dysfunction, and renal failure are common complications in such infants, and in the presence of renal failure, the serum levels of calcium and inorganic phosphorus should be maintained below the pathologic level to avoid ectopic calcification of the tissues, including the myocardium.
Department of Pediatrics, Hahnemann University Hospital, Philadelphia, PA 19102.
R P
RP
Verma
E M
EM
Smergel
K
K
Chandrasekaran
D002114:Calcinosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002118:Calcium / Q000097:blood; D009202:Cardiomyopathies / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003402:Creatine Kinase / Q000097:blood; D003681:Dehydration / Q000150:complications / Q000628:therapy; D004298:Dopamine / Q000627:therapeutic use; D004452:Echocardiography; D005260:Female; D005440:Fluid Therapy; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy; D006962:Hyperparathyroidism, Secondary / Q000150:complications* / Q000209:etiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D010758:Phosphorus / Q000097:blood; D011137:Polystyrenes / Q000627:therapeutic use; D011188:Potassium / Q000097:blood
D011137:Polystyrenes; D010758:Phosphorus; C003321:polystyrene sulfonic acid; D005665:Furosemide; D003402:Creatine Kinase; D011188:Potassium; D002118:Calcium; D004298:Dopamine