A stable L-arginine-dependent relaxing factor released from cytotoxic-activated macrophages.
It has been known that cytotoxic-activated macrophages release an unstable vasorelaxing substance, nitric oxide. We have found that a more stable relaxing factor is released from those cells. This factor seems to be synthesized from L-arginine. It acts through the activation of soluble guanylate cyclase without affecting membrane potential. It has little charge at nearly neutral pH, and its molecular weight is < 500.
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
H
H
Uchizumi
R
R
Hattori
K
K
Sase
W J
WJ
Cai
K
K
Kadota
S
S
Sasayama
C
C
Kawai
Y
Y
Yui
D000818:Animals; D001011:Aorta / Q000502:physiology; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D002478:Cells, Cultured; D004355:Drug Stability; D008264:Macrophages / Q000378:metabolism* / Q000502:physiology*; D011817:Rabbits; D013237:Stereoisomerism; D014661:Vasoconstriction / Q000502:physiology; D014665:Vasodilator Agents / Q000378:metabolism*; D019323:omega-N-Methylarginine
D014665:Vasodilator Agents; D019323:omega-N-Methylarginine; D001120:Arginine