The multifunctional Ca2+/calmodulin-dependent protein kinases.
Ca2+ mediates the effect of many hormones, neurotransmitters and growth factors on contractility and motility, carbohydrate metabolism, cell cycle, gene expression and neuronal plasticity. Multifunctional Ca2+/calmodulin-dependent (CaM) kinase, CaM kinase Ia, CaM kinase Ib and CaM kinase IV are four of the kinases that mediate Ca(2+)-signaling pathways. Recent studies have clarified our understanding of their structure, regulation and function.
Department of Pharmacology, Stanford University School of Medicine, California 94305-5332.
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Schulman
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D008954:Models, Biological; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes; D010766:Phosphorylation; D011494:Protein Kinases
D009097:Multienzyme Complexes; D011494:Protein Kinases; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002118:Calcium