Increased levels of NGF in sera of systemic lupus erythematosus patients.
Using a specific enzyme-linked immunosorbent assay (ELISA) for human nerve growth factor (NGF), serum levels in patients with systemic lupus erythematosus (SLE) were measured. We found a consistent increase in NGF levels in SLE patients compared with controls. A good correlation exists between serum NGF level and severity of clinical manifestation. We hypothesize that NGF might play a role in the pathogenesis of autoimmune disorders such as SLE.
Institute of Neurobiology, CNR, Rome, Italy.
L
L
Bracci-Laudiero
L
L
Aloe
R
R
Levi-Montalcini
M
M
Galeazzi
D
D
Schilter
J L
JL
Scully
U
U
Otten
D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005190:Family; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood* / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins