Long-term administration of probucol and QTc interval prolongation.
Electrocardiographic QTc intervals were measured in twenty-one hypercholesterolemic patients before and after long-term probucol (500-1,000 mg/day for 30 months) treatment. Probucol reduced serum total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C). Mean QTc interval prolongation after probucol was 17 msec. A positive correlation was found between the change in QTc interval after probucol (delta QTc) and the total amount of probucol administered. delta QTc was negatively correlated to the pre-treatment QTc interval. No correlation was observed between serum probucol concentrations and delta QTc. Neither clinical evidence of cardiotoxicity nor critical arrhythmias were noted during the treatment period.
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
N
N
Sasaki
K
K
Saku
K
K
Moroe
B
B
Zhang
K
K
Hirata
R
R
Liu
K
K
Arakawa
D000368:Aged; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011341:Probucol / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D011341:Probucol