Ageing and monoamine turnover in the lateral geniculate nucleus and visual cortex of the rat.
The effects of ageing on the turnover of dopamine, noradrenaline and serotonin in the lateral geniculate nucleus and the visual cortex were evaluated, using high performance liquid chromatography (HPLC) with electrochemical detection. Compared to adult animals, aged rats showed more changes in the visual cortex than in the lateral geniculate nucleus, with dopamine turnover decreased in both structures and noradrenaline turnover unaltered. Changes in serotonin turnover were witnessed only in the visual cortex. A decrease in the monoamine oxidase-A to -B ratio was also observed with increased age for both the lateral geniculate nucleus and visual cortex.
Departamento de Bioquímica, Bromatología y Toxicología Facultad de Farmacia, Universidad de Sevilla, Spain.
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AJ
Herrera
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Machado
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Cano
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism*; D004563:Electrochemistry / Q000379:methods; D005829:Geniculate Bodies / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism*
D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine