Atherosclerotic tissue analysis by time-resolved XeCl excimer laser reflectometry.
The temporal modification of XeCl laser pulses reflected from human aorta tissue immersed in saline has been studied. Dynamic tissue reflectivity of both normal and atherosclerotic tissues has been examined for various incident pulse fluences between 0.7 and 6.5 J/cm2. Changes in reflected pulse duration are observed for fluences at or above 2.6 J/cm2 with normal tissue targets and 3.0 J/cm2 with calcified plaque. Such reflected pulse analysis may prove useful in identifying tissue targets for ablation during laser angioplasty.
FDA Center for Devices and Radiological Health, Rockville, Maryland 20857.
G H
GH
Pettit
R
R
Sauerbrey
F K
FK
Tittel
D
D
Weilbacher
P D
PD
Henry
D000328:Adult; D016342:Angioplasty, Laser / Q000295:instrumentation; D001011:Aorta / Q000473:pathology; D001018:Aortic Diseases / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology; D002712:Chlorides; D006801:Humans; D007834:Lasers; D055095:Optics and Photonics; D012965:Sodium Chloride; D017539:Tunica Intima / Q000473:pathology; D014978:Xenon
D002712:Chlorides; D014978:Xenon; D012965:Sodium Chloride; C048006:xenon chloride