Increased interleukin 6, but reduced interleukin 1, in delayed pressure urticaria.
Interleukin 1 (IL-1) and interleukin 6 (IL-6) were measured by bioassays in suction-blister exudates from lesional skin, from skin immediately following a pressure challenge, and from control skin (not subjected to pressure) of patients with delayed pressure urticaria. IL-6 activity in lesional exudates was significantly higher than in exudates from the other two sites. IL-1 activity in lesional exudates was not significantly higher than in the control exudates, but significantly less IL-1 activity was found immediately after pressure challenge than from the control site.
St John's Institute of Dermatology, St Thomas' Hospital, London, U.K.
F
F
Lawlor
C
C
Bird
R D
RD
Camp
R
R
Barlow
R M
RM
Barr
A
A
Kobza-Black
M R
MR
Judge
M W
MW
Greaves
D000328:Adult; D005122:Exudates and Transudates / Q000276:immunology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011312:Pressure / Q000009:adverse effects; D014581:Urticaria / Q000276:immunology*
D007375:Interleukin-1; D015850:Interleukin-6