Kinetics of drug transfer to the fetus.
Experimental studies in animal models have contributed significantly to our understanding of the pharmacokinetics of drug disposition in the maternal-fetal unit. This chapter has considered some of the factors that are important in determining the extent of fetal exposure to drugs that are consumed by the mother during pregnancy. A knowledge of the maternal-fetal pharmacokinetics of the drugs of abuse will help provide a better understanding of the limitations of the current methods used in perinatal drug screening and in the interpretation of the results.
Szeto
H H
HH
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D002188:Cannabis; D003042:Cocaine / Q000493:pharmacokinetics*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006197:Hair / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D008470:Meconium / Q000378:metabolism; D009294:Narcotics / Q000493:pharmacokinetics*; D011247:Pregnancy
D009294:Narcotics; D003042:Cocaine