Gamma radiation-induced differentiation on human neuroblastoma cells in culture.
We have studied the effect of gamma radiation on differentiation in neuroblastoma cell lines AF8 and SJ-N-KP. Growth inhibition and morphological and biochemical differentiation have been examined following radiation exposure to 1-10 Gy. Gamma radiation induced marked growth inhibition and morphological differentiation in a dose-and time-dependent manner in both cell lines, and induced biochemical differentiation in AF8 cells.
Istituto di Cancerologia, Università di Bologna, Italy.
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P
Rocchi
A M
AM
Ferreri
G
G
Simone
D
D
Granchi
P
P
Nanni
A
A
Frau
P
P
Paolucci
G
G
Paolucci
D000110:Acetylcholinesterase / Q000378:metabolism; D002454:Cell Differentiation / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D016130:Immunophenotyping; D009447:Neuroblastoma / Q000201:enzymology / Q000473:pathology / Q000532:radiotherapy*; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D000110:Acetylcholinesterase