The role of insulin and renin in the pathogenesis of hormone-dependent neoplasias. b). Renin.
Recently, a prorenin-renin-angiotensin system which could be correlated to the reproductive function, although independent from the renal renin-angiotensin complex, has been observed also at ovarian level. It had been supposed that the renin itself by influencing the metabolism of steroid hormones is responsible for the pathogenesis of hormone-dependent neoplasias, endometrial and breast carcinoma. This would lead to the consideration of hypertension as a primary risk factor for such pathologies and not only as secondary to obesity. This research has not, however, revealed significant relations between the plasmatic concentration of renin and the hormone variation responsible for the pathogenesis of hormone-dependent neoplasias.
Maggino
T
T
Gynaecologic Obstetric Institute, University of Padua, Italy.
Marcadella
C B
CB
Romagnolo
C
C
D000273:Adipose Tissue; D000735:Androstenedione / Q000097:blood; D001794:Blood Pressure; D001943:Breast Neoplasms / Q000209:etiology*; D003687:Dehydroepiandrosterone / Q000097:blood; D016889:Endometrial Neoplasms / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology* / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D012083:Renin / Q000097:blood / Q000502:physiology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D012083:Renin