Ploidy status and the response of T1 glottic carcinoma to radiotherapy.
Flow cytometric DNA ploidy measurements were performed on formalin fixed paraffin embedded tumour specimens from patients with a T1 glottic laryngeal carcinoma in order to evaluate the role of DNA content in relation to local control. From 1980 to 1987, a consecutive series of 90 patients with a T1 glottic laryngeal carcinoma were treated by radiotherapy with curative intent. Biopsies from 44 of these patients were readily available for DNA flow cytometry. In this group aneuploidy was associated with a significantly higher risk (P = 0.018) of local recurrence within 2 years after completion of radiotherapy (38% vs. 9% in the diploid group).
Department of Otolarynology, Head & Neck Surgery, The Netherlands Cancer Institute, Amsterdam.
H A
HA
Westerbeek
W J
WJ
Mooi
F J
FJ
Hilgers
G
G
Baris
A C
AC
Begg
A J
AJ
Balm
D000368:Aged; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies
D004273:DNA, Neoplasm