Hypertension secondary to chlorpropamide with amelioration by changing to insulin.
A retrospective analysis of the records of 22 type II diabetics whose treatment had been changed from insulin to chlorpropamide was performed to investigate the relative effects of insulin and chlorpropamide on blood pressure. Although diastolic BP index was not significantly different between the treatments, systolic BP index was significantly higher on chlorpropamide than on insulin (141 +/- 3 v 135 +/- 3 mm Hg, P = .02). In 10 patients in whom insulin was reinstituted, systolic BP fell significantly (P < .005), suggesting that in type II diabetics chlorpropamide exerts a relative hypertensive effect in comparison to insulin.
Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA 23249.
J K
JK
Schmitt
J R
JR
Moore
D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D002747:Chlorpropamide / Q000009:adverse effects* / Q000627:therapeutic use; D016206:Databases, Bibliographic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D007328:Insulin; D002747:Chlorpropamide