Studies in hypotensive agents. Synthesis and hypotensive activity of 3,4-dihydro-1(2H)-benzoxepine oxime ethers and their derivatives.
Substituted oximino-ethers of 3,4-dihydro-1(2H)-benzoxepines were synthezised from 3,4-dihydro-1(2H)benzoxepin-5-ones. The hypotensive activity of these compounds was evaluated on anaesthetized cats.
Tandon
V K
VK
Department of Chemistry, Lucknow University, India.
Chandra
A
A
Dua
P R
PR
Srimal
R C
RC
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001584:Benzoxepins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000959:Antihypertensive Agents; D001584:Benzoxepins; D010091:Oximes