Fetal circulatory endothelin-1,2 in the midtrimester.
Umbilical-vein blood from eight fetuses who underwent cordocentesis for rapid karyotyping at 19-22 gestational weeks was tested for immunoreactive endothelin-1,2 by means of radioimmunoassay. Endothelin was detected in the serum of all but one of these fetuses. Levels of endothelin-1,2 ranged from 8.5 to 19.2 fmol/ml (mean 13.4 fmol/ml). We speculate that endothelin in the fetoplacental circulation may play a role in the regulation of fetal hemodynamics in utero.
Schiff
E
E
Department of Obstetrics and Gynecology, Tel-Aviv University, Israel.
Zalel
Y
Y
Friedman
S A
SA
Shalev
E
E
D017218:Cordocentesis; D016232:Endothelins / Q000097:blood*; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D011863:Radioimmunoassay
D016232:Endothelins