Pharmacokinetics of single-dose administration of naproxen at 10:00 and 22:00 hours.
The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations.
Rao
B R
BR
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Rambhau
D
D
Rao
V V
VV
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D009288:Naproxen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D009288:Naproxen