Cancer invasion and metastasis.
Mechanisms by which primary tumors invade local tissues and spread to distant sites are beginning to be understood. Included are factors involved in cell-to-cell and cell-to-extracellular matrix interactions, motility factors, and genetic controls. Knowledge of such mechanisms is spurring development of novel therapeutic agents for clinical study.
Laboratory of Pathology, National Cancer Institute, Bethesda.
Y S
YS
Kim
L A
LA
Liotta
E C
EC
Kohn
D006801:Humans; D008967:Molecular Biology; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*