[The effect of azathioprine treatment on IgG subclasses in multiple sclerosis].
IgG and its subclasses: IgG1, IgG2, IgG3 and IgG4 were determined in the CSF and sera from 20 patients with multiple sclerosis before and after treatment with azathioprine. The effect of the treatment on IgG and IgG subclasses intrathecal synthesis was studied as well. There was a decrease in IgG level in the CSF of MS patients after the treatment with azathioprine. This was mainly due to the decrease of IgG1 and IgG2 subclasses levels. There was no evidence of the influence of azathioprine treatment on IgG and its subclasses levels in MS sera as well as on IgG and IgG subclasses intrathecal synthesis.
Losy
J
J
Katedry i Kliniki Neurologii AM, Poznaniu.
Michałowska-Wender
G
G
Wender
M
M
D000328:Adult; D000911:Antibodies, Monoclonal; D001379:Azathioprine / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D001379:Azathioprine
Wpływ leczenia azatiopryna na podklasy IgG w stwardnieniu rozsianym.