Mastoparan B, synthesis and its physical and biological properties.
Mastoparan B, a tetradecapeptide toxin (LKLKSIVSWAKKVL) isolated from the hornet (Vespa basalis) venom, was synthesized chemically. The physical and biological properties of both the native and synthetic peptides were studied and proved to be identical. Mastoparan B was found to have a potent antibacterial activity to both Gram negative and Gram positive bacteria.
Yu
H M
HM
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Wu
T M
TM
Chen
S T
ST
Ho
C L
CL
Her
G R
GR
Wang
K T
KT
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004487:Edema / Q000139:chemically induced; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006168:Guinea Pigs; D036341:Intercellular Signaling Peptides and Proteins; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016339:Spectrometry, Mass, Fast Atom Bombardment
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C081223:mastoparan B