Photosensitization with anticancer agents. 18. Perylenequinonoid pigments as potential photodynamic therapeutic agents: preparation and photodynamic properties of amino-substituted hypocrellin derivatives.
Perylenequinonoid pigments have demonstrated several photodynamic therapeutic advantages over the commonly used hematoporphyrin derivatives. Certain new amino-substituted hypocrellin B derivatives have been prepared, and both direct and reductive aminations of hypocrellin B are described. The photophysical and photochemical properties of the amino-substituted hypocrellin B derivatives were investigated, and their significantly enhanced red absorptivities and strong 1O2-generating functions qualify them as promising photodynamic therapeutic agents. In addition, the superoxide anion radical was also determined to be implicated in the photosensitization of the amino-substituted hypocrellin B derivatives.
Department of Chemistry, University of Alberta, Edmonton, Canada.
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D000586:Amination; D000970:Antineoplastic Agents / Q000737:chemistry*; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D019800:Phenol; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry*; D017382:Reactive Oxygen Species; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011809:Quinones; D017382:Reactive Oxygen Species; D019800:Phenol; D010569:Perylene; C048388:hypocrellin A