HLA A/B recombination in a white woman with the S-s-phenotype of the MNS system.
In cases of disputed parentage, the possibility of simultaneous occurrence of rare events in the population must be considered. PURPOSE--To report a case in which HLA-A/B recombination and homozygosity of a silent allele, typical of Negroes, in an individual apparently without this miscegenation were coexistent. METHODS--Alleged father, mother and dizygotic twin children were racially classified according to their apparent somatic characters. Blood group genetic markers of ABO, Rh, MNS, Kell, Duffy, HLA-A, -B systems were phenotyped; mother's HLA genotyping was performed by her parents test. RESULTS--The phenotype of the White mother, in the MNS system, was M+; N-; S-; s-. Alleged father and both twins were phenotipically compatible. The assumed maternity relating to both children was possible if mother presented an HLA-A/B recombination. CONCLUSION--In miscegenated populations, the breakup between ethnical appearance and blood group markers is foreseeable. Allele/haplotypic frequencies of these populations should be estimated. Casuistically, the association of events with low frequency in the population can be the cause of apparent exclusions of parentage.
Salaru
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Instituto de Medicina Social e Criminologia de São Paulo.
D000483:Alleles; D005260:Female; D005819:Genetic Markers; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics; D010334:Paternity; D010641:Phenotype; D011995:Recombination, Genetic
D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D008951:MNSs Blood-Group System