Characteristics of the effects of the angiotensin converting enzyme inhibitor cilazapril on diurnal blood pressure.
Patients with stage I or II essential hypertension were assigned to receive 1 mg of cilazapril once daily in the morning (n = 11; mean age, 63 years); 2 mg of cilazapril once daily in the morning (n = 8; mean age, 60 years); or 1 mg of cilazapril twice daily (n = 9; mean age, 68 years). Blood pressure was recorded for 24 hours before treatment began and after 2 weeks of treatment. After all three doses of cilazapril, both systolic and diastolic blood pressures were lower than before treatment. Greater reductions in blood pressure were found after 2 mg of cilazapril daily than 1 mg daily. The antihypertensive effect of cilazapril was greater during the daytime than during the night. When the blood pressure effect was analyzed by the cumulative percentage method, it was noted that, after the two once-daily regimens, the magnitude of the blood pressure reduction was greater at higher blood pressures and smaller at lower blood pressures. No such trend was apparent after the twice-daily dose of cilazapril.
Nakanishi
T
T
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan.
Takahashi
H
H
Nishimura
M
M
Yoshimura
M
M
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D017315:Cilazapril / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D017315:Cilazapril