[Estradiol benzoate test in the study of pituitary block induced by triptorelin].
The suppression of the positive oestradiol (E2) feed-back mechanism was studied in 21 patients during treatment with long acting GnRHa-triptorelin 3.75 mg (Ipsen-Biotech). A basal sample for FSH, LH and E2 evaluation was taken before a single administration of 2.5 mg of oestradiol benzoate (EB) i.m. at 24 and 48 hours later. The test was performed 1, 2, 3, 4, 5, 6 and 7 weeks after i.m. injection of GnRHa. The E2 concentration 24 hours after EB injection was > 400 pg/ml, able to induce, in physiological conditions, a positive feedback. In the other hand no FSH an LH rise was observed in all test after 1, 2, 3, 4, 5, 6 and 7 weeks from GnRHa administration. Our results show the absolute suppression of the positive feed-back mechanism during the treatment with a single dose of long acting tryptorelin 3.75 mg i.m., the same results were obtained until the 7th week after GnRHa administration.
Istituto di Ricovero e Cura a Carattere Scientifico S. De Bellis, Castellana Grotte, Bari.
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Vizziello
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D'Amato
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Trentadue
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Fanizza
D000328:Adult; D001565:Benzoates; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004958:Estradiol; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D006801:Humans; D007273:Injections, Intramuscular; D007986:Luteinizing Hormone / Q000032:analysis; D010902:Pituitary Gland / Q000187:drug effects*; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000494:pharmacology*
D001565:Benzoates; D003692:Delayed-Action Preparations; D017329:Triptorelin Pamoate; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Studio dinamico del blocco ipofisario indotto dalla triptorelina, mediante test all'estradiolo benzoato.