Weak resistance to oxidation of native lipoproteins in Wistar rats.
We report an impressive decline in plasma lipid resistance to oxidation during Triton-WR-1339-induced hyperlipidemia in rats. This decline is associated with a modification in the balances between alpha-tocopherol and lipids and alpha-tocopherol and ascorbate. These results are consistent with a weak resistance of accumulated native lipoproteins in plasma to oxidation, during a 6-hour time course, and they suggest a misunderstood role of lipoprotein catabolic enzymes: to improve this characteristic. Conclusively, the results lead us to propound Triton-induced hyperlipidemia as an original model for studying the balance impairment between antioxidants and oxidizable substrates.
Department of Biochemistry, UFR des Saints-Pères, Paris, France.
H
H
Antébi
L
L
Zimmermann
L
L
Malagrida
R
R
Pecquery
D
D
Olichon
Y
Y
Giudicelli
L G
LG
Alcindor
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D005227:Fatty Acids / Q000032:analysis; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013501:Surface-Active Agents / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D013501:Surface-Active Agents; D014810:Vitamin E; D011092:Polyethylene Glycols; D001205:Ascorbic Acid; C016811:tyloxapol