The sequence-specific nuclear matrix binding factor F6 is a chicken GATA-like protein.
The sequence-specific DNA-binding protein factor F6, which binds upstream of the cluster of the chicken alpha-globin genes, has previously been found to interact with a DNA fragment containing a replication origin and a nuclear matrix binding site. This protein has been partially characterized. Based on its molecular weight and binding affinity, F6 belongs to a family of GATA proteins, the chicken equivalent of transcription factor NFE-1. An oligonucleotide including the binding site for F6 competes for binding of the above-mentioned DNA fragment to the nuclear matrix. This indicates an involvement of this protein in the interaction between DNA and the nuclear matrix.
Institut Jacques Monod, Paris, France.
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Vassetzky
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De Moura Gallo
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Bogdanova
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Razin
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Scherrer
D000818:Animals; D034961:Antigens, Nuclear; D001483:Base Sequence; D002461:Cell Line, Transformed; D002645:Chickens; D004268:DNA-Binding Proteins / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D004214:Distamycins / Q000494:pharmacology; D050981:Erythroid-Specific DNA-Binding Factors; D050982:GATA1 Transcription Factor; D008969:Molecular Sequence Data; D015530:Nuclear Matrix / Q000737:chemistry*; D009687:Nuclear Proteins / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors
D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; D004214:Distamycins; D050981:Erythroid-Specific DNA-Binding Factors; D050982:GATA1 Transcription Factor; D009687:Nuclear Proteins; D014157:Transcription Factors; C030000:stallimycin