Observations on the treatment of autochthonous tumors in mice with an enterovirus and cyclophosphamide.
Significant remissions in autochthonous mammary tumors in A/Strong mice were effected in 45% of treated animals with a vaccine prepared with an enterovirus plus cyclophosphamide. Three methods of vaccine preparation were examined. Only one was effective although all three contained viable viruses. The data are consistent with the interpretation that the effective vaccine stimulated the host reticuloendothelial (RE) system differentially so that partial destruction with cyclophosphamide resulted in the reprograming of the RE system in favor of host control.
Medical Department, Lawrence Livermore National Laboratory, California.
M W
MW
Biggs
J E
JE
Eiselein
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D004769:Enterovirus Infections / Q000276:immunology*; D007108:Immune Tolerance; D007167:Immunotherapy; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008805:Mice, Inbred A; D014765:Viral Vaccines / Q000276:immunology
D014765:Viral Vaccines; D003520:Cyclophosphamide