Epigenetic inheritance in mammals.
The epigenetic phenomena of genome imprinting and X-chromosome inactivation, found in mammals, both entail homologous genes or chromosomes behaving differently within the same cell. Although both have consequences for genic balance in the whole genome, in imprinting the control seems mainly at the single gene level, whereas in X-chromosome inactivation there is coordinated regulation of the whole chromosome, and single gene effects are relatively minor.
MRC Radiobiology Unit, Didcot, Oxon, UK.
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Lyon
D000818:Animals; D004303:Dosage Compensation, Genetic; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008322:Mammals / Q000235:genetics*; D051379:Mice; D014960:X Chromosome