[Effect of cytokines on eosinophil differentiation and proliferation].
IL-3, IL-5, and GM-CSF are eosinopoietic cytokines that induce the proliferation and differentiation of eosinophils. However, the regulatory mechanism of eosinopoiesis is largely unknown. A combination of IL-3 and IL-5 induces selective proliferation and differentiation of eosinophils from mononuclear cell fractions of human cord blood. IFN-gamma decreases the IL-3- and IL-5-induced eosinophil differentiation in a dose-dependent manner. IL-4 and IL-2 also decrease the IL-3- and IL-5-induced eosinophil differentiation. These observations indicate that IL-2, IL-4, and IFN-gamma have a direct or indirect inhibitory effect on eosinopoiesis.
Second Department of Internal Medicine, Chiba University School of Medicine.
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Ochiai
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Iwamoto
D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000166:cytology*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology* / Q000502:physiology; D007376:Interleukin-2 / Q000494:pharmacology* / Q000502:physiology; D015847:Interleukin-4 / Q000494:pharmacology* / Q000502:physiology
D007376:Interleukin-2; D015847:Interleukin-4; D007371:Interferon-gamma