[Current role of doxycycline in the chemoprophylaxis of Plasmodium falciparum malaria].
In countries where chemoresistance of Plasmodium falciparum is high (group III), mefloquine must be advocated for malaria prophylaxis for a stay less than 3 months. If it is more and particularly in Indo-china peninsular countries (Thailand, Birmania, Kamputchéa, Laos, Vietnam) and in Amazonia, advocated chemoprophylaxis is doxycycline 100 mg per day. Authors remind action mechanism, contraindication and side effects of this drug. Others publications underline the good tolerance of doxycycline now used by 1,400 french soldiers staying for 6 months with United Nations Organisation in Kamputchéa. An evaluation of tolerance and efficiency of this chemoprophylaxis is now in progress.
Gras
C
C
Institut de Médecine tropicale, Service de Santé des Armées, Le Pharo, Marseille.
Laroche
R
R
Guelain
J
J
Martet
G
G
Merlin
M
M
Pottier
G
G
Guisset
M
M
Touze
J E
JE
D001210:Asia, Southeastern; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control*; D015767:Mefloquine / Q000627:therapeutic use; D013020:South America
D004318:Doxycycline; D015767:Mefloquine
Place actuelle de la doxycycline dans la chimioprophylaxie du paludisme à Plasmodium falciparum.