Influences of high dietary fat and/or indomethacin on tumor proliferation and cell kinetics of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in rats.
We investigated the effects of a high-fat diet and indomethacin on tumorigenesis, tumor proliferation and cell kinetics of 7,12-Dimethylbenz(a)anthracene (DMBA)--induced mammary carcinomas in Sprague-Dawley (SD) rats. Both the high-fat diet and indomethacin significantly stimulated tumor proliferation and cell kinetics, whereas tumorigenesis was significantly stimulated by the high-fat diet but it was significantly inhibited by indomethacin. Moreover, switching the animals from the high-fat diet with or without indomethacin to the low-fat diet suppressed tumor proliferation and cell kinetics. It can therefore be concluded that either a high-fat diet or indomethacin stimulates tumor proliferation in DMBA--induced mammary carcinoma in SD rats.
Department of Surgery (II), School of Medicine, Kanazawa University, Japan.
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Noguchi
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Ohta
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D015994:Incidence; D007213:Indomethacin / Q000494:pharmacology*; D007700:Kinetics; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004273:DNA, Neoplasm; D004041:Dietary Fats; D015127:9,10-Dimethyl-1,2-benzanthracene; D001973:Bromodeoxyuridine; D007213:Indomethacin