Imipramine treatment of alcoholism with comorbid depression.
Of 60 depressed alcoholics who completed an open trial of imipramine, 27 (45%) responded with improvement in both mood and drinking behavior, and eight (13%) responded after further dosage increases or treatment with disulfiram. In a subsequent 6-month, randomized discontinuation trial, four of 13 subjects (31%) relapsed during imipramine treatment and seven of 10 (70%) relapsed while taking placebo. This suggests a potential treatment approach for a high-risk subgroup of alcoholics.
Depression Evaluation Service, New York State Psychiatric Institute, NY 10032.
E V
EV
Nunes
P J
PJ
McGrath
F M
FM
Quitkin
J P
JP
Stewart
W
W
Harrison
E
E
Tricamo
K
K
Ocepek-Welikson
D000328:Adult; D000339:Affect / Q000187:drug effects; D000428:Alcohol Drinking / Q000188:drug therapy; D000437:Alcoholism / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology; D004221:Disulfiram / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007099:Imipramine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D016584:Panic Disorder / Q000453:epidemiology; D010865:Pilot Projects; D010919:Placebos; D012008:Recurrence; D012107:Research Design / Q000592:standards
D010919:Placebos; D007099:Imipramine; D004221:Disulfiram