Generation and regeneration of cells of the B-lymphocyte lineage.
B lymphopoiesis in the mouse and in man can be divided into two phases, one in which the compartments of the B lineage are filled with cells, and a second in which these compartments are maintained by regeneration, turnover and selection. Once the immune system has been built it contains around 5 x 10(8) and 10(12) cells of the B-lymphocyte lineage in the mouse and in man, respectively, of which nearly 10 per cent are precursors that are active in regeneration, whereas over 90 per cent are resting, mature B cells.
Rolink
A
A
Basel Institute for Immunology, Switzerland.
Melchers
F
F
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D002455:Cell Division; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D015322:Gene Rearrangement, B-Lymphocyte; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D018398:Homeodomain Proteins; D006801:Humans; D051379:Mice / Q000276:immunology; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology; D008822:Mice, Transgenic / Q000276:immunology; D009687:Nuclear Proteins; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D011506:Proteins; C499311:RAG2 protein, human; C499308:Rag2 protein, mouse; D017452:Receptors, IgG; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein