Influence of non-L-type calcium channel antagonists on phencyclidine-induced effects in rats.
Omega-conotoxin (1 and 2 micrograms/10 microliter i.c.v.), a N-type calcium channel blocker, and amiloride (7.5 and 15 micrograms/10 microliter i.c.v.), a T-type calcium antagonist, significantly prevented the EEG and behavioural effects induced by phencyclidine (PCP, 5 mg/kg i.p.) in rats. In accordance with previous studies showing the significant influence of L-type calcium blockers in the same model, these results confirm that the modulation of calcium currents plays a key role in the expression of PCP-induced effects.
Pharmacology Department, Istituto Superiore di Sanità, Rome, Italy.
P
P
Popoli
A
A
Pèzzola
A
A
Scotti de Carolis
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D020960:omega-Conotoxins
D002121:Calcium Channel Blockers; D010456:Peptides, Cyclic; D020960:omega-Conotoxins; C053423:Conus magus toxin; D000584:Amiloride; D010622:Phencyclidine