Immunohistochemical localization of cathepsins B and D in the synovial lining cells of the normal rat temporomandibular joint.
In 1 micron-thick serial cryosections, cathepsins B and D were found to coexist in both type A (macrophage-like) and type B (fibroblast-like) cells: the whole cytoplasm of the type A cells showed strong immunoreactivity, while the type B cells contained a few granular reaction products. It is therefore suggested that type A cells have a marked ability for intracellular digestion of organic materials.
Kiyoshima
T
T
First Department of Oral Surgery, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
Tsukuba
T
T
Kido
M A
MA
Tashiro
H
H
Yamamoto
K
K
Tanaka
T
T
D000818:Animals; D002401:Cathepsin B / Q000032:analysis*; D002402:Cathepsin D / Q000032:analysis*; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013583:Synovial Membrane / Q000201:enzymology*; D013704:Temporomandibular Joint / Q000201:enzymology*
D002401:Cathepsin B; D002402:Cathepsin D