Androgen concentration by a sexually dimorphic population of tachykinin-immunoreactive neurons in the rat ventral premammillary nucleus.
Strong connections with sexually dimorphic nuclei suggest that the ventral premammillary nucleus (PMv) may be involved in the mediation of reproductive behavior. Steroid autoradiography and immunohistochemistry were used to show that: (1) there is a sex difference in the numbers of PMv neurons that contain tachykinin peptides, (ii) dihydrotestosterone concentrating cells are densely distribution in the PMv and about a quarter of these also contain immunoreactive tachykinin and, (iii) size of the immunoreactive tachykinin population does not respond to alterations in levels of gonadal steroids in adulthood. Thus the PMv appears to make a contribution to the regulation of sexual behavior through androgen-concentrating, tachykinin-containing pathways that are anatomically distinct from estrogen receptive circuitry.
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164.
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Akesson
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D013196:Dihydrotestosterone / Q000494:pharmacology; D005260:Female; D008297:Male; D008326:Mammillary Bodies / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D009474:Neurons / Q000276:immunology / Q000502:physiology*; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000502:physiology; D015320:Tachykinins / Q000276:immunology / Q000502:physiology*
D000728:Androgens; D015320:Tachykinins; D013196:Dihydrotestosterone