RNA polymerase II transcription cycles.
RNA polymerase II interacts with transcription factors to initiate the synthesis of mRNA. These interactions are cyclic, involving multiple RNA polymerase subunits and general transcription factors. Phosphorylation of the RNA polymerase II carboxyl-terminal domain may regulate these interactions.
Howard Hughes Medical Institute, Johns Hopkins Medical School, Baltimore, MD 21205.
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D000595:Amino Acid Sequence; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D012319:RNA Polymerase II / Q000378:metabolism*; D012808:Sigma Factor / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
D012808:Sigma Factor; D014157:Transcription Factors; D012319:RNA Polymerase II