Patterns of nerve regeneration in dental pulps of monkeys following surgical transection at 1 year.
Previous studies have reported revascularization and reorganization of dental pulp chambers with periodontal tissues of monkeys following complete surgical transection through a portion of the apical roots. This study observed 128 teeth in four adult monkeys. Following surgical transection, the tissues were acquired by perfusion fixation, serially sectioned, and stained for cellular detail with hematoxylin and eosin. Collagen tissues were stained with Preece's trichrome and neural tissues with Rowles' silver cyanate for controlled impregnation. At 1 and 2 weeks the coronal tissues showed tissue disruption, necrosis, and degenerating nerves. The 3- and 4-week tissues that had been completely transected showed replacement healing of the pulp tissue with periodontal ligament connective tissue, but no nerves were present. At 6 weeks, no nerves were present in the coronal chambers of those teeth with complete vital transection. The 24-, 36-, and 52-week pulp chambers with complete transection failed to show nerve fibers in their reorganized connective tissues.
Department of Orthodontics, University of North Carolina, School of Dentistry, Chapel Hill.
L J
LJ
Bailey
P L
PL
Sadowsky
C
C
Nelson
J B
JB
Hassanali
C F
CF
Cox
D000818:Animals; D003782:Dental Pulp / Q000294:innervation*; D003787:Dental Pulp Devitalization; D005260:Female; D008137:Longitudinal Studies; D008253:Macaca mulatta; D009416:Nerve Regeneration; D010027:Osteotomy / Q000009:adverse effects*; D010513:Periodontal Ligament / Q000503:physiopathology; D014092:Tooth Root / Q000293:injuries* / Q000294:innervation