[Muscle carnitine contents in severely handicapped children with acute myoglobinuria].
Muscle carnitine was measured in 3 severely handicapped children with acute myoglobinuria. Muscle total carnitine levels were 9.6 +/- 3.0 nmol/mg non collagen protein (m +/- SD, control 15.7 +/- 2.8, n = 19), and free 6.5 +/- 3.0 nmol/mg non collagen protein (m +/- SD, control 12.9 +/- 3.7, n = 19), muscle free carnitine was significantly low in them. Serum carnitine was measured in 22 severely handicapped children. Serum total carnitine was 48.9 +/- 12.3 nmol/ml (m +/- SD, control 60.3 +/- 11.7, n = 14), and free 37.7 +/- 10.0 nmol/ml (m +/- SD, control 46.0 +/- 12.5, n = 14), serum carnitine was also significantly decreased. Secondary muscle and serum carnitine depletion might be one of the potential cause of myoglobinuria in severely handicapped children.
Sato
H
H
Department of Pediatrics, Hamamatsu University Medical School, Shizuoka.
Sugie
H
H
Sugie
Y
Y
Ito
M
M
Tsurui
S
S
Igarashi
Y
Y
Ishikawa
A
A
D000367:Age Factors; D002331:Carnitine / Q000097:blood / Q000172:deficiency / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009212:Myoglobinuria / Q000209:etiology / Q000378:metabolism*
D002331:Carnitine