Effect of a somatostatin analogue (SMS 201-995) on antral gastrin cell hyperplasia and hypergastrinemia induced by a histamine H2-receptor antagonist.
The effect of a somatostatin analogue, SMS 201-995 (SMS), on antral gastrin cell hyperplasia (AGH) and hypergastrinemia associated with 14-day administration of the histamine H2-receptor antagonist (H2-RA) famotidine was studied in rats. When the famotidine group was compared with the control group, the antral gastrin cell (G-cell) number was significantly increased (P < 0.01) by approximately twofold, and the serum gastrin level was significantly increased (P < 0.01) by approximately sixfold. When the famotidine+SMS group was compared with the famotidine group, the G-cell number was significantly decreased (P < 0.01) by approximately 30%, and the serum gastrin level was significantly decreased (P < 0.01) by approximately 40%. These findings suggest that SMS may be useful for inhibiting AGH and hypergastrinemia induced by long-term H2-RA administration.
Dept. of Surgery (II), Jikei University School of Medicine, Tokyo, Japan.
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Kimura
D000818:Animals; D004759:Enterochromaffin Cells / Q000187:drug effects* / Q000473:pathology; D015738:Famotidine / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005755:Gastrins / Q000097:blood*; D006965:Hyperplasia; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D005755:Gastrins; D015738:Famotidine; D015282:Octreotide