Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2).
By use of rat cDNA probes and a panel of cell hybrids segregating rat chromosomes, the genes encoding three pyridoxal 5'-phosphate (PLP)-dependent decarboxylases--namely, DOPA-decarboxylase (Ddc), glutamic acid decarboxylase 1 and 2 (Gad1 and Gad2)--were assigned to rat Chromosomes (Chrs) 14, 3, and 17, respectively. If one takes into account chromosome localizations in the human and the mouse, the present results (i) show that a synteny group is retained on rat Chr 14, human Chr 7, and mouse Chr 11 (Ddc); (ii) strengthen the homology relation known between rat Chr 3 and human and mouse Chrs 2 (Gad1); (iii) suggest that rat Chr 17 has no extensive homology to any human chromosome; and (iv) suggest the order (Prl, Fdp)--Tpl2--Gad2 on the rat Chr 17.
Laboratoire de Biocheimie Cellulaire, Collège de France, Paris.
C
C
Vassort
M
M
Rivière
G
G
Bruneau
F
F
Gros
J
J
Thibault
G
G
Levan
J
J
Szpirer
C
C
Szpirer
D000818:Animals; D002874:Chromosome Mapping; D004296:Dopa Decarboxylase / Q000235:genetics*; D005819:Genetic Markers; D005968:Glutamate Decarboxylase / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice; D051381:Rats / Q000235:genetics*; D013045:Species Specificity
D005819:Genetic Markers; D007527:Isoenzymes; D004296:Dopa Decarboxylase; D005968:Glutamate Decarboxylase