Localized amyloidosis in squamous cell carcinoma of uterine cervix: electron microscopic features of nodular and star-like amyloid deposits.
An ultrastructural study of amyloid deposits in four cases of squamous cell carcinoma of uterine cervix was performed. The amyloid deposits reacted with anti-keratin antiserum on frozen sections. Amyloid deposits showed nodular (4 cases) and star-like forms (3 cases). Nodular amyloid deposits were composed of slightly whorled fibrils, measuring 7-10 nm in width. Some of them contained cellular debris and thicker, more electron-dense filaments than amyloid fibrils. In three cases, filamentous tumour cells and filamentous masses were observed together with amyloid. Star-like amyloid deposits were composed of bundles of straight amyloid fibrils. Some of the tumour cells in contact with star-like amyloid deposits had deep cytoplasmic invaginations, where closely packed amyloid fibrils were arrayed in parallel fashion. In addition, a few tumour cells had membrane-bound amyloid fibrils in the cytoplasm. It is suggested that nodular amyloid deposits are derived from the tumour cells through filamentous degeneration. Amyloid fibrils in star-like amyloid deposits are thought to be formed within the cytoplasm or in the vicinity of invaginated cytoplasmic membranes of the tumour cells.
Gondo
T
T
First Department of Pathology, Yamaguchi University School of Medicine, Japan.
Ishihara
T
T
Kawano
H
H
Uchino
F
F
Takahashi
M
M
Iwata
T
T
Matsumoto
N
N
Yokota
T
T
D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism* / Q000648:ultrastructure*; D000686:Amyloidosis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure
D000682:Amyloid