Lack of clinical evidence of sodium retention in children with idiopathic short stature treated with recombinant growth hormone.
In adults patients, administration of human growth hormone and growth hormone synthesized by recombinant DNA technology (rGH) results in sodium and fluid retention and weight gain. This study was performed to determine whether rGH administration in children with idiopathic short stature (ISS) caused any clinical evidence of sodium retention. The parameters assessed included blood pressure, height, weight, plasma renin activity (PRA), aldosterone, and atrial natriuretic peptide (ANP). These were measured in nine treated children after 0, 3, 6, 9, and 12 months of growth hormone therapy; seven untreated children served as controls. After 12 months, the treated children had no significant increases in measurements of blood pressure, PRA, aldosterone, and ANP. Although treated children gained more weight than control patients, they also grew faster. Therefore, there was no significant difference in weight for height percentile for treated children when compared with normal controls. After 1 year of therapy, the administration of rGH to children with ISS does not result in any clinically significant evidence of sodium retention.
Department of Pediatrics, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY 10467.
J
J
DiMartino-Nardi
S
S
Wesoly
L
L
Schwartz
P
P
Saenger
D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000378:metabolism; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*
D011994:Recombinant Proteins; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D013006:Growth Hormone; D012964:Sodium; D012083:Renin