Trichinella spiralis: the effect of specific antibody on muscle larvae in the small intestines of weaned rats.
Weaned rats were passively immunized with rat IgG2c monoclonal antibodies previously shown to protect infant rats against challenge with Trichinella spiralis. Although the antibodies did not protect rats against infection, the course of larval establishment in the intestine was altered in a way that has not been described previously. Specifically, larvae that invaded the epithelium were inhibited from migrating from intestinal tissue into saline during the standard recovery procedure. The inhibition was reversed at a time coincident with the first moult. Whole serum from infected rats had a similar effect. These results show that specific antibodies influence T. spiralis larvae in the intestinal epithelium, yet fail to effect their expulsion from adult rats.
James A. Baker Institute, Department of Microbiology, Immunology and Parasitology, Cornell University, Ithaca, New York 14853.
O E
OE
Otubu
M S
MS
Carlisle-Nowak
D D
DD
McGregor
R H
RH
Jacobson
J A
JA
Appleton
D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D007116:Immunization, Passive; D007421:Intestine, Small / Q000469:parasitology*; D007814:Larva; D009093:Mucus / Q000469:parasitology; D009132:Muscles / Q000469:parasitology; D051381:Rats; D017160:Trichinella spiralis / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D014235:Trichinellosis / Q000276:immunology* / Q000469:parasitology; D014886:Weaning
D000909:Antibodies, Helminth; D000911:Antibodies, Monoclonal