HLA and Singaporean Chinese myasthenia gravis.
Chinese Singaporean myasthenia gravis (MG) patients are associated with three HLA haplotypes: Cw1 B46 DRB1*0901 DQB1*0303 DQA1*03, DRB1*14 DRB3*0202 DQB1*0503 DQA1*0101 and DRB1*1202 DRB3*0301 DQB1*0301 DQA1*0601. The B46 haplotype was associated with the total group of MG patients but in particular with those with younger onset, low antiacetylcholine receptor (anti-AchR) titres, with only ocular lesions and with normal thymuses. The DRB1*14 haplotype was associated with thymic hyperplasia, younger onset patients, with high anti-AchR titres and with generalised MG. The DRB1*1202 haplotype was associated with thymoma, older onset patients, ocular lesions, and mid to high anti-AchR titres.
WHO Immunology Centre, Faculty of Medicine, National University of Singapore.
S H
SH
Chan
C B
CB
Tan
Y N
YN
Lin
G B
GB
Wee
M A
MA
Degli-Esposti
R L
RL
Dawkins
D000328:Adult; D000483:Alleles; D005128:Eye Diseases / Q000473:pathology; D005260:Female; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D006965:Hyperplasia; D008297:Male; D009157:Myasthenia Gravis / Q000235:genetics / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011950:Receptors, Cholinergic / Q000032:analysis; D012846:Singapore; D013950:Thymus Gland / Q000473:pathology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D011950:Receptors, Cholinergic