Ouabain--a local, paracrine, aldosterone synthesis regulating hormone?
10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone production by ouabain is suggested depending on extracellular potassium concentration.
Szalay
K S
KS
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D006728:Hormones / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D010042:Ouabain; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015383:Zona Fasciculata / Q000378:metabolism; D015384:Zona Glomerulosa / Q000378:metabolism
D006728:Hormones; D000450:Aldosterone; D010042:Ouabain; D011188:Potassium