A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism.
Specific point mutations which affect viral tropism have been identified in both the V3 loop and in the CD4-binding region of the human immunodeficiency virus type 1 surface glycoprotein gp120. Here we report that a single point mutation in the first variable region (V1) of human immunodeficiency virus type 1 strain JRCSF is responsible for a change in viral tropism.
Boyd
M T
MT
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
Simpson
G R
GR
Cann
A J
AJ
Johnson
M A
MA
Weiss
R A
RA
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D002478:Cells, Cultured; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008969:Molecular Sequence Data; D017354:Point Mutation; D013601:T-Lymphocytes / Q000382:microbiology; D050378:T-Lymphocytes, Regulatory / Q000382:microbiology
D015699:HIV Envelope Protein gp120