Nucleotide, dinucleotide and trinucleotide frequencies explain patterns observed in chaos game representations of DNA sequences.
The chaos game representation (CGR) is a scatter plot derived from a DNA sequence, with each point of the plot corresponding to one base of the sequence. If the DNA sequence were a random collection of bases, the CGR would be a uniformly filled square; conversely, any patterns visible in the CGR represent some pattern (information) in the DNA sequence. In this paper, patterns previously observed in a variety of DNA sequences are explained solely in terms of nucleotide, dinucleotide and trinucleotide frequencies.
Laboratory of Mathematical Biology, National Institute for Medical Research, London, UK.
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Goldman
D001483:Base Sequence; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D005914:Globins / Q000235:genetics; D008433:Mathematics; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011336:Probability
D009838:Oligodeoxyribonucleotides; D005914:Globins; D004247:DNA