Effect of human granulocyte colony-stimulating factor on neutropenia induced by radiotherapy and chemotherapy.
This study was designed to test the effect of human granulocyte colony-stimulating factor (hG-CSF) in patients at risk for neutropenia caused by radiotherapy plus chemotherapy. Twelve patients with advanced esophageal tumor were treated after operation with 'sandwich' radiochemotherapy (successive treatment with chemotherapy-radiotherapy-chemotherapy). hG-CSF was given subcutaneously at a dose of 2 micrograms/kg/day for 3-5 days after the white blood cell counts decreased to less than 3,000/mm3. Neutrophil counts significantly recovered to normal levels within 5 days in all patients treated with hG-CSF. No significant changes in the lymphocyte, platelet and red blood cell counts were shown. No side effects were observed. These results indicate that hG-CSF is a useful tool for the treatment of neutropenia induced by radiotherapy and chemotherapy.
Department of Radiology, University of Tokyo, School of Medicine, Japan.
K
K
Sakata
Y
Y
Aoki
N
N
Muta
A
A
Therahara
K
K
Karasawa
Y
Y
Onogi
K
K
Nakagawa
K
K
Hasezawa
Y
Y
Sasaki
A
A
Akanuma
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D004938:Esophageal Neoplasms / Q000628:therapy*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*
D000970:Antineoplastic Agents; D016178:Granulocyte-Macrophage Colony-Stimulating Factor