Sequence determination of variable region genes of two human monoclonal antibodies against Neisseria meningitidis.
Nucleotide sequences for the variable regions of both the heavy and light chains for two human monoclonal antibodies have been determined. Both antibodies are directed against an outer membrane protein of Neisseria meningitidis, and their genes show a low resemblance to germline sequences.
Department of Immunotechnology, Lund University, Sweden.
M
M
Ayala Avila
J
J
Vazques
L
L
Danielsson
M E
ME
Fernández de Cossío
C A
CA
Borrebaeck
D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial / Q000235:genetics*; D000911:Antibodies, Monoclonal / Q000235:genetics*; D001483:Base Sequence; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D008969:Molecular Sequence Data; D009345:Neisseria meningitidis / Q000276:immunology*
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region