[Effect of hemodilutional autotransfusion on coagulative-fibrinolytic dynamics and metabolic response].
We studied the effect of hemodilutional autotransfusion on coagulative-fibrinolytic dynamics and metabolic response. Hemodilutional solutions used were Dextran-40 (group A) and Salin-HES (group B). The activated partial thromboplastin time (APTT) immediately after hemodilution was prolonged in both groups. Prothrombin time (PT) and hepaplastin decreased significantly, and a remarkable variation was observed particularly in group A. The results suggest that effect on fibrinolytic dynamics is not exerted in either group because antithrombin-III (AT-III) and fibrinogen decreased significantly, while fibrinogen degradation products (FDP) are within normal ranges, and plasminogen as well as alpha 2-plasmin inhibitor (alpha 2-PI) decreased significantly. On the other hand, all other parameters such as lactic acid level, pyruvic acid level in blood, lactic acid pyruvic acid ratio, and blood glucose level were elevated during surgery, but no difference was observed regarding these parameters between the two groups.
Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
M
M
Kobori
A
A
Hosoyamada
N
N
Satoh
S
S
Kouno
K
K
Gomi
D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D005342:Fibrinolysis / Q000502:physiology*; D006438:Hemodilution; D006801:Humans; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time