[The characteristics of the development of bacterial enterotoxemia and endotoxemia in combined radiation and thermal lesions].
Thermal burn of irradiated rats increases the level and the length of the postirradiation enteroendotoxemia and aggravates the postirradiation impairment of the hematoenterocitic barrier. The pharmacological correction of the small intestine motility and introduction of ciproheptadine, an agent that blocks serotonin receptors, ameliorates the above phenomenon in radiation and thermal injuries.
Budagov
R S
RS
Nesterenko
V S
VS
Piskarev
A V
AV
Chureeva
L N
LN
D000818:Animals; D002056:Burns / Q000150:complications* / Q000188:drug therapy; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000528:radiation effects; D003533:Cyproheptadine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins / Q000097:blood*; D004767:Enterotoxemia / Q000188:drug therapy / Q000209:etiology*; D004926:Escherichia coli; D005720:Gamma Rays; D007421:Intestine, Small / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014115:Toxemia / Q000188:drug therapy / Q000209:etiology*; D014916:Whole-Body Irradiation
D004731:Endotoxins; D003533:Cyproheptadine
Osobennosti razvitiia bakterial'noĭ énteroéndotoksemii pri kombinirovannykh radiatsionno-termicheskikh porazheniiakh.