In vitro binding of a novel dopamine D3 receptor ligand: [125I]trans-7-OH-PIPAT-A.
An iodinated dopamine D3 receptor ligand, [125I]trans-7-OH-PIPAT-A-trans-7-hydroxy-2-(N-n-propyl-N-3'-iodo-2 '- propenyl)aminotetralin, was developed. This ligand demonstrated unique high affinity and selectivity toward the dopamine D3 receptor; Kd = 0.48 nM and Bmax = 240 fmol/mg of protein in rat striatal membrane homogenates.
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
M P
MP
Kung
H F
HF
Kung
S
S
Chumpradit
C
C
Foulon
D000818:Animals; D001665:Binding Sites; D016466:CHO Cells; D003342:Corpus Striatum / Q000378:metabolism*; D006224:Cricetinae; D066298:In Vitro Techniques; D008024:Ligands; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes / Q000378:metabolism*
D008024:Ligands; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; C081289:7-hydroxy-2-(N-n-propyl-N-(3-iodo-2'-propenyl)-amino)tetralin