Blood levodopa levels and unified Parkinson's disease rating scale function: with and without exercise.
We studied 10 regular exercising men with Parkinson's disease on levodopa (LD) under two conditions--no exercise and vigorous exercise started 1 hour after LD ingestion. We compared LD levels and motor scores on the Unified Parkinson's Disease Rating Scale (UPDRS). There was a high degree of agreement between plasma LD level and the patients' UPDRS scores 30 minutes later (mean Eta2 = 0.84) in both conditions, with no difference between the two. We conclude that LD levels accurately reflect UPDRS motor function in these patients, and that vigorous exercise started 1 hour after LD ingestion does not influence LD or motor scores.
Goetz
C G
CG
Department of Neurological Sciences, Rush-Presbyterian, St. Luke's Medical Center, Chicago, IL 60612.
Thelen
J A
JA
MacLeod
C M
CM
Carvey
P M
PM
Bartley
E A
EA
Stebbins
G T
GT
D000368:Aged; D015444:Exercise; D006801:Humans; D007980:Levodopa / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005082:Physical Exertion
D007980:Levodopa