Renin activation correlates with blood amount and distribution in subarachnoid haemorrhage.
Blood extent and localization visible in CCT predicts complications and prognosis in patients suffering from subarachnoid haemorrhage (SAH). Plasma renin activity (PRA) elevation is one of the hormonal parameters of autonomic disorders after SAH and its prognostic relevance could be confirmed by this study, too. But the correlation of PRA with blood amount and distribution was the main target of this study. Large amounts of blood are connected with higher PRA-levels and more PRA-rises. Even a linear correlation between the amount of blood defined by a CCT-score and PRA in ng ml h-2 could be established. A significant correlation was found between intraventricular, suprasellar blood, ventricular enlargement of the third/lateral ventricles and PRA-elevations. Disorders of hypothalamic and/or medullary centres of sympathetic control are thought to be the underlying cause and to depend on blood extent and distribution.
Hamann
G
G
Department of Neurology, University of the Saarland, Homburg/Saar, Germany.
Isenberg
E
E
Stoll
M
M
Huber
G
G
Strittmatter
M
M
Schimrigk
K
K
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood; D001810:Blood Volume / Q000502:physiology*; D004789:Enzyme Activation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000201:enzymology*; D014057:Tomography, X-Ray Computed
D009320:Atrial Natriuretic Factor; D012083:Renin