Mercury contents of indicators and target organs in rats after long-term, low-level, mercury vapor exposure.
Five groups of Wistar rats received graded concentrations of mercury vapor from 10 to 100 micrograms Hg/m3 6 hr, 5 days a week, from 4 to 11 weeks of age. One group breathing ambient air served as controls. The mercury levels of the indicators blood, hair, molars, and incisors as well as the target organs kidney cortex, cerebrum, cerebellum, liver, lung, spleen, tongue, and femur were measured by cold-vapor atomic absorption spectrophotometry. The mercury vapor had no negative influence on the weight gain of the animals. The results showed that the kidney cortex had the highest concentration of mercury. The mercury contents of all the indicators and all the target organs, with the exception of femur, were positively and significantly correlated with the exposure concentration. The rat molars had the highest correlation coefficient with the kidney mercury values, but no indicator had a significant correlation with all target organs. Rat molars are to some degree comparable to human deciduous teeth regarding time of mineralization and eruption. Based on the results presented in this study, we tentatively suggest that human deciduous teeth can be useful indicators of chronic mercury exposure not only at the exposure concentration level, but also as indicators of the mercury uptake in organs such as kidney and cerebrum.
Department of Anatomy, University of Bergen, Norway.
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Eide
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Wesenberg
D000818:Animals; D001835:Body Weight; D001923:Brain Chemistry; D005260:Female; D005269:Femur / Q000737:chemistry; D007672:Kidney Cortex / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D008628:Mercury / Q000032:analysis* / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000737:chemistry; D014018:Tissue Distribution; D014059:Tongue / Q000737:chemistry; D014070:Tooth / Q000737:chemistry; D014835:Volatilization; D015430:Weight Gain
D008628:Mercury