Regio- and stereo-selectivity in the induction of peroxisome proliferation by substituted hexanoic acids.
Quantitative structure-activity relationship is an effective tool in order to predict drug potency. A similar approach is actually developed for peroxisome proliferation induced by substituted carboxylic acids issued from plasticizer metabolism in rats. The study is focused on acids found in rat urine after adipic diester dosings. Size, location of the substituted group and length of the chain have been studied. 3-D structure has also been taken in account for 2-ethyl hexanoic acids. The results obtained so far demonstrate that peroxisome proliferation potencies of the considered acids are modified according structure changes. At this time location of the group along the chain appears to be a predominant factor.
ENS BANA, Université de Bourgogne, Dijon, France.
A C
AC
Macherey
I
I
Leguy
S
S
Gregoire
G
G
Tainturier
J C
JC
Lhuguenot
D000818:Animals; D002208:Caproates / Q000494:pharmacology*; D002478:Cells, Cultured; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008830:Microbodies / Q000187:drug effects*; D008968:Molecular Conformation; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D002208:Caproates