Changes in platelet membrane fluidity of migraine patients.
Platelet membrane fluidity was measured in migraine patients, with and without aura, using the fluorescent probe TMA-DPH (1-[4-(trimethylammonium) phenyl]-6-hexa-1,3,5- triene). Polarization values for TMA-DPH were significantly higher in the platelet membranes of migraine patients (with or without aura) than in those of healthy subjects. These findings signify decreased membrane fluidity and may explain some modifications in receptors, carriers or enzymes described in platelets of migraine patients.
Cotrim
M D
MD
Laboratory of Pharmacology, Faculty of Pharmacy, Institute of Pharmacology, Coimbra, Portugal.
Ribeiro
C A
CA
de Macedo
T dos R
Tdos R
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004161:Diphenylhexatriene / Q000031:analogs & derivatives; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D008560:Membrane Fluidity; D008881:Migraine Disorders / Q000097:blood* / Q000150:complications; D009422:Nervous System Diseases / Q000209:etiology; D012016:Reference Values
D005456:Fluorescent Dyes; D004161:Diphenylhexatriene; C033628:1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene