Spinal cord edema following freezing injury in the rat: relationship between tissue water content and spinal cord blood flow.
A spinal cord edema model was developed in the rat by inflicting a freezing injury at -40 degrees C for 3 minutes. Regional spinal cord blood flow, tissue water content, and histology were examined. White matter edema had extended several segments by 8 hours after the injury. Tissue water content increased by 20.6% at 24 hours. Spinal cord blood flow in surrounding tissues decreased by more than 25% 4 hours after the injury. The progression of spinal cord edema following freezing injury appeared to be due to disruption of the blood-spinal cord barrier.
Wang
R
R
Department of Neurosurgery, Kobe University, Japan.
Ehara
K
K
Tamaki
N
N
D000818:Animals; D001834:Body Water / Q000737:chemistry*; D004487:Edema / Q000378:metabolism / Q000503:physiopathology*; D005615:Freezing; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000098:blood supply*; D013118:Spinal Cord Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*