Milk cholesterol concentration in sows selected for three generations for high or low serum cholesterol.
Female crossbred swine (Chester White x Landrace x Large White x Yorkshire) selected for three generations for low (L, n = 24) or high (H, n = 26) serum cholesterol at 8 wk of age were milked at d 20 or 21 of their first lactation to measure cholesterol, fat, lactose, protein, and ash concentrations. A contemporary, unselected control (C) group from the same original population (third lactation, n = 7) was sampled concurrently. All sows were fed a standard gestation, then lactation, diet that contained no cholesterol or added fat (all plant, corn-soybean meal). Genetic selection for low or high serum cholesterol at 8 wk of age induced corresponding changes in milk cholesterol and fat concentration in the third generation of selection, but not in any other milk constituents. Milk cholesterol concentrations (milligrams/100 grams fresh weight) were L, 25.3 +/- 3.0; C, 35.7 +/- 8.0; and H, 41.4 +/- 6.9 (L < C < H, P < .01). Corresponding values for milk fat were 5.7 +/- 1.3, 7.2 +/- .8, and 7.0 +/- .8 mg (L < C = H, P < .01). Serum cholesterol concentrations at 8 wk of age were L, 66.1 +/- 8.1; C, 93.7 +/- 13.7; and H, 126.2 +/- 9.7 mg/dL (P < .01). Milk cholesterol concentration was significantly correlated with serum cholesterol (r = .782, P < .01) and milk fat (r = .36, P < .01). It seems that selecting swine for low or high serum cholesterol at 8 wk of age induced changes in lipid metabolism reflected in differences in milk cholesterol concentrations.
Cooperative Agricultural Research Center, Prairie View A&M University, TX 77446.
M M
MM
Kandeh
Y W
YW
Park
W G
WG
Pond
L D
LD
Young
D000818:Animals; D001947:Breeding; D002784:Cholesterol / Q000032:analysis* / Q000097:blood; D005260:Female; D007774:Lactation; D008055:Lipids / Q000032:analysis; D008297:Male; D008892:Milk / Q000737:chemistry*; D012641:Selection, Genetic; D013552:Swine / Q000097:blood* / Q000235:genetics / Q000502:physiology
D008055:Lipids; D002784:Cholesterol