The immunoregulatory roles of transforming growth factor beta.
Transforming growth factor-beta is a 25 kD polypeptide produced by both healthy and neoplastic cells. This cytokine effects the introduction of immune response, but its exact mechanism remains to be elucidated. In this paper the immuno-regulatory role of this cytokine on both the immunocompetent cells and accessory molecules is discussed. The growth factor-induced up and down regulation of the immune response suggest that transforming growth factor-beta can done some extent modulate certain pathological conditions, and hence suppressed production of this growth factor has potential benefits for bimodal immunotherapy.
Department of Dental Public Health, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia.
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Sosroseno
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Herminajeng
D006801:Humans; D007107:Immune System / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000276:immunology*
D016212:Transforming Growth Factor beta