125I embedded in an orbital prosthesis for retreatment of recurrent retinoblastoma.
The application of radiation therapy in the retreatment of unilateral recurrent retinoblastoma presents a very difficult dilemma in which consideration must be given to preservation of vision in the remaining eye while tumoricidal doses of irradiation are delivered. A technique is described in which a methylmetraculate eye sphere carrying a single Iodine-125 seed was used to deliver local irradiation to the orbital tissues in a patient with multiple episodes of recurrent retinoblastoma. The tissue dose at 2 mm depth was 2630 cGy while the dose to the retina of the remaining eye and to the optic chiasm was negligible.
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710.
G C
GC
Bentel
E C
EC
Halperin
E G
EG
Buckley
D001918:Brachytherapy / Q000379:methods*; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D005137:Eye, Artificial; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D011879:Radiotherapy Dosage; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery
D007457:Iodine Radioisotopes