Variations of protein C in uremic hemodialysed patients.
Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagulant activity of protein C has been found impaired in eight cases whereas other inhibitors were normal. In four cases, both anticoagulant and antigenic levels were low. In one case, amidolytic method could also found a low activity. Hemodialysis leads to an increase of protein C activity and antigen level. Heparinemia after hemodialysis does not interfere with the chronometric measurement of protein C anticoagulant activity. Total protein level, hematocrit, protein S and antithrombin III are also elevated after hemodialysis. Baseline fibrinolytic parameters are normal and remain unchanged after hemodialysis. The clinical relevance of such modifications is discussed.
Laboratoire central d'Hématologie, CHU, Reims.
P
P
Nguyen
O
O
Toupance
J
J
Chanard
G
G
Potron
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis; D020151:Protein C Deficiency; D017293:Protein S / Q000032:analysis; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D001798:Blood Proteins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III