Endometrial estrogen and progesterone receptors within 2-14 days of missed menses in the human.
Serial changes in the endometrial levels of estrogen and progesterone receptors (ER and PR) were measured in 50 women from days 2 to 14 of missed menses and correlated with the plasma concentrations of hCG, progesterone and 17 beta-estradiol. Both ER and PR of nuclei were higher than cytosolic proteins, with a shift in the ratio of nER/nPR to nPR from 4th day after missed menses. On Scatchard analysis of the cytosolic and nuclear binding proteins, two classes of proteins, corresponding to Type I and II, were found. While the increasing levels of hCG maintained luteal secretion of progesterone and 17 beta-estradiol at normal mid-luteal phase levels, a gradual increase in 17 beta estradiol from 9th day of missed menses was noted. This delicate balance between circulating levels of progesterone and 17 beta-estradiol and their nuclear receptors at early stages of pregnancy may be of significance.
Department of Anatomy and Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India.
K
K
Garg
P
P
Sujata
G L
GL
Kumari
P K
PK
Pandey
V
V
Padubidri
C
C
Anand
D002467:Cell Nucleus / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000097:blood; D003600:Cytosol / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism* / Q000648:ultrastructure; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008598:Menstruation; D011247:Pregnancy / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D013997:Time Factors
D006063:Chorionic Gonadotropin; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol