Predicting recurring miscarriage: what is important?
OBJECTIVE
To audit the Miscarriage Clinic in Liverpool and to categorize women into those at low and high risk of a subsequent pregnancy loss.


METHODS
Over 4 years (1989-1992), 203 consecutive couples attended the Miscarriage Clinic in Liverpool. A data base was designed and a mathematical model formulated that described the data base.


RESULTS
A successful pregnancy outcome was most likely in the presence of the following features: menstrual regularity, fewer than four previous miscarriages, maternal age of less than 30 years, absence of antiphospholipid antibodies, and a previous live birth. Oligomenorrhea was a considerably more significant feature than any other in predicting a subsequent miscarriage. These high-risk oligomenorrheic women were found to have low luteal phase estradiol levels, but normal luteal phase progesterone profiles and normal LH profiles throughout the menstrual cycle.


CONCLUSIONS
Women suffering from recurring miscarriage can be placed into differing risk categories. Women with a good prognosis require counseling alone. Women at high risk of a subsequent miscarriage had oligomenorrhea and an isolated deficiency of estradiol in the luteal phase of the menstrual cycle.
Quenby
S M
SM
Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom.
Farquharson
R G
RG
D000026:Abortion, Habitual / Q000175:diagnosis* / Q000209:etiology; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008423:Maternal Age; D009839:Oligomenorrhea / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome; D012372:ROC Curve; D012008:Recurrence; D012307:Risk Factors
D017153:Antibodies, Anticardiolipin; D004958:Estradiol; D007986:Luteinizing Hormone