[Muscle carnitine contents in severely handicapped children with acute myoglobinuria].
Muscle carnitine was measured in 3 severely handicapped children with acute myoglobinuria. Muscle total carnitine levels were 9.6 +/- 3.0 nmol/mg non collagen protein (m +/- SD, control 15.7 +/- 2.8, n = 19), and free 6.5 +/- 3.0 nmol/mg non collagen protein (m +/- SD, control 12.9 +/- 3.7, n = 19), muscle free carnitine was significantly low in them. Serum carnitine was measured in 22 severely handicapped children. Serum total carnitine was 48.9 +/- 12.3 nmol/ml (m +/- SD, control 60.3 +/- 11.7, n = 14), and free 37.7 +/- 10.0 nmol/ml (m +/- SD, control 46.0 +/- 12.5, n = 14), serum carnitine was also significantly decreased. Secondary muscle and serum carnitine depletion might be one of the potential cause of myoglobinuria in severely handicapped children.
Department of Pediatrics, Hamamatsu University Medical School, Shizuoka.
H
H
Sato
H
H
Sugie
Y
Y
Sugie
M
M
Ito
S
S
Tsurui
Y
Y
Igarashi
A
A
Ishikawa
D000367:Age Factors; D002331:Carnitine / Q000097:blood / Q000172:deficiency / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009212:Myoglobinuria / Q000209:etiology / Q000378:metabolism*
D002331:Carnitine