Radioimmunoconjugates in the detection of infection and inflammation.
Various nuclear medicine techniques are widely used to image foci of infection and inflammation. Among the relatively new radiopharmaceuticals for this purpose are radioimmunoconjugates such as labeled murine monoclonal antigranulocyte antibodies and labeled human polyclonal nonspecific immunoglobulin G. This article reviews some background information, mechanism of action, side effects, biodistribution, kinetics, results of clinical studies, and dosimetry of several radioimmunoconjugates both of murine monoclonal and human polyclonal origin. The efficacy of these agents has been demonstrated in a variety of clinical conditions. Radiolabeled immunoconjugates may emerge as convenient alternatives to the present technique of choice: in vitro blood cell labeling techniques with their inherent problems and risks.
Department of Nuclear Medicine, University Hospital Nijmegen, The Netherlands.
F H
FH
Corstens
W J
WJ
Oyen
W S
WS
Becker
D006801:Humans; D007205:Indium Radioisotopes; D007239:Infections / Q000000981:diagnostic imaging*; D007249:Inflammation / Q000000981:diagnostic imaging*; D016719:Radioimmunodetection; D013667:Technetium
D007205:Indium Radioisotopes; D013667:Technetium