Monitor lyophilization with mass spectrometer gas analysis.
This paper presents a brief review of the basic issues of lyophilization and the fundamentals of quadrupole mass spectrometry. The emphasis of the paper is on the application of a quadrupole mass spectrometer as a process monitor. The details of sampling and data collection are discussed. Data taken while monitoring lyophilization is presented in conjunction with cycle optimization, end point detection and contaminant detection.
NGS Division of MKS Instruments, Inc., Walpole, MA.
J P
JP
Connelly
J V
JV
Welch
D000097:Acetonitriles / Q000032:analysis; D005612:Freeze Drying / Q000592:standards; D013058:Mass Spectrometry; D012710:Serum Albumin, Bovine; D012997:Solvents / Q000032:analysis; D013997:Time Factors; D014867:Water / Q000032:analysis
D000097:Acetonitriles; D012997:Solvents; D014867:Water; D012710:Serum Albumin, Bovine; C032159:acetonitrile