Effect of in vitro acyclovir treatment on selected functions of blood-derived macrophages.
The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and the production of interferon and tumor necrosis factor were slightly enhanced, while the production of lysozyme was reduced, in a dose-dependent manner. Interferon production was also reduced in the presence of high concentrations of ACV.
Stenseth
A M
AM
Institute of Bacteriology, Rikshospitalet, University of Oslo, Norway.
Rollag
H
H
Degré
M
M
D000212:Acyclovir / Q000494:pharmacology*; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D009000:Monocytes / Q000187:drug effects* / Q000502:physiology; D009113:Muramidase / Q000096:biosynthesis; D010587:Phagocytosis / Q000187:drug effects; D011961:Receptors, Fc / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016898:Interferon-alpha; D011961:Receptors, Fc; D014409:Tumor Necrosis Factor-alpha; D009113:Muramidase; D000212:Acyclovir