Anorectic specificity as measured in a choice paradigm in rhesus monkeys.
The present report describes a new procedure for assessing anorectic specificity. Two rhesus monkeys (Macaca mulatta) surgically prepared with indwelling intragastric catheters were trained in a discrete trial choice paradigm to respond for either food or visual access to a room containing other monkeys. Our hypothesis was that a specific anorectic would reduce only food-maintained responding; responding to open a window would either not be affected or would increase. Caloric preloads, d-amphetamine, (d,l)-fenfluramine, and cholecystokinin octapeptide all decreased food-maintained responding and had no effect on or increased responding maintained by window opening. These results demonstrate that choice procedures are useful for assessing anorectic specificity.
Corwin
R L
RL
Department of Psychiatry, University of Chicago, IL 60637.
Schuster
C R
CR
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology; D005502:Food; D008253:Macaca mulatta; D008297:Male; D012646:Self Administration
D001067:Appetite Depressants; D005277:Fenfluramine; D002766:Cholecystokinin; D000661:Amphetamine