Inhibition of benzoyl peroxide-induced tumor promotion and progression by copper(II)(3,5-diisopropylsalicylate)2.
The ability of a biomimetic superoxide dismutase agent, copper(II)(3,5-diisopropylsalicylate)2 (CuDIPS), to modulate benzoyl peroxide (BzPo)-induced tumor promotion and progression in mouse skin multistage carcinogenesis was evaluated. The results showed a significant inhibition of tumor incidence by CuDIPS pretreatment during promotion-progression. Different types of tumors were developed: papillomas, keratoacanthomas and squamous cell carcinomas. There was a significant increase in the keratoacanthoma-papilloma ratio when the period of treatment with BzPo was prolonged, which was inhibited by CuDIPS pretreatment. CuDIPS induced a significant inhibition of malignant conversion. Our results suggest that reactive oxygen species could be important in BzPo-induced promotion and progression.
Comisión Nacional de Energía Atómica, Departamento de Radiobiología, Buenos Aires, Argentina.
H A
HA
Durán
H
H
Lanfranchi
M A
MA
Palmieri
B M
BM
de Rey
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001585:Benzoyl Peroxide; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000517:prevention & control; D003043:Cocarcinogenesis; D005260:Female; D015994:Incidence; D007636:Keratoacanthoma / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D012459:Salicylates / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D000970:Antineoplastic Agents; D012459:Salicylates; C030865:copper bis(3,5-diisopropylsalicylate); D015127:9,10-Dimethyl-1,2-benzanthracene; D001585:Benzoyl Peroxide