Copperglycinate protects mice exposed to various doses of gamma radiation.
Mice administered with various doses of copperglycinate (= glycine copper complex = GC) 15 min before exposure to various doses of gamma radiation showed an increased survival as compared to the non-drug treated irradiated control. It was also observed that 750 mg/kg body weight of GC was superior to the 500 and 1000 mg/kg body weight of GC as is evidenced by higher number of survivors in this group. The free radical scavenging activity of GC increased linearly with increasing drug dose.
Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India.
G C
GC
Jagetia
N G
NG
Ganapathi
M K
MK
Unnikrishnan
D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D016166:Free Radical Scavengers; D005720:Gamma Rays; D005998:Glycine / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000627:therapeutic use* / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D013047:Specific Pathogen-Free Organisms
D003037:Cobalt Radioisotopes; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D011837:Radiation-Protective Agents; C018493:cupric glycinate; D005998:Glycine