Increased concentration of endothelin messenger RNA in the mesenteric arteries of cyclosporine-induced hypertensive rats.
The aim of this study was to investigate the expression of endothelin-1 (ET-1) in the mesenteric arteries of cyclosporine-induced hypertensive rats. The concentration of plasma ET-1 and of mesenteric artery ET-1 messenger RNA was measured in cyclosporine-induced hypertensive and control rats. The concentration of ET-1 messenger RNA in the mesenteric arteries of cyclosporine-treated rats (25 mg/kg/day for 6 weeks) was significantly greater than in control rats (P < .05). We propose that cyclosporine-induced hypertension may be due to an increased synthesis of ET-1 in the resistant vessels.
Takeda
Y
Y
Second Department of Internal Medicine, Kanazawa University, Japan.
Miyamori
I
I
Yoneda
T
T
Takeda
R
R
D000818:Animals; D016572:Cyclosporine; D016232:Endothelins / Q000097:blood / Q000235:genetics*; D006973:Hypertension / Q000097:blood / Q000139:chemically induced* / Q000235:genetics*; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism*; D009994:Osmolar Concentration; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D016232:Endothelins; D012333:RNA, Messenger; D016572:Cyclosporine