[Cytogenetics of unfertilized or undivided oocytes within the scope of in vitro fertilization: relation to the kind of hormonal stimulation].
A cytogenetic analysis could be performed on 343 out of 566 oocytes which remained unfertilized or uncleaved during our in vitro fertilization (IVF) programme. The results were analyzed in relation to the kind of ovarian stimulation by classification of the patients into two groups: treatment with human menopausal gonadotropin (hMG) or treatment with clomiphene citrate (CC). There was no significant difference for the total rates of abnormal oocytes (hMG: 28.6%, CC: 32.2%), the rates of aneuploidy (hMG: 14.4%, CC: 16.9%), and the rates of hyperhaploidy (hMG: 3.9%, CC: 8.5%). These results suggest that the kind of medication for induction of multiple follicular growth does not influence the rate of cytogenetic anomalies in human oocytes.
Abteilung Frauenheilkunde und Geburtshilfe, Universität Ulm.
B
B
Rosenbusch
K
K
Sterzik
V
V
Sasse
M
M
Djalali
D002869:Chromosome Aberrations / Q000235:genetics*; D002970:Cleavage Stage, Ovum / Q000187:drug effects*; D002996:Clomiphene / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage; D010062:Ovulation Induction; D011003:Ploidies
D002996:Clomiphene; D008596:Menotropins
Zytogenetik unbefruchteter oder ungeteilt gebliebener Eizellen im Rahmen der In vitro-Fertilisation: Beziehungen zur Art der hormonellen Stimulation.