Trabeculectomy and Molteno implantation for glaucomas associated with uveitis.
OBJECTIVE
This study compares the outcomes of trabeculectomy and Molteno implantation in the treatment of glaucomas associated with uveitis.


METHODS
Forty-five patients with uveitis, who had undergone filtering surgery for glaucomas associated with uveitis, were reviewed retrospectively. Successful outcome was defined as final intraocular pressure (IOP) of 6 to 21 mmHg, with a minimum follow-up of 6 months without visually devastating complications or loss of light perception.


RESULTS
One- and two-year life-table success rates, respectively, were 81% and 73% with trabeculectomy (16 patients); 53% and 31% with combined trabeculectomy and first-stage (reserve) Molteno implantation (19 patients); and 79% and 79% with one-stage Molteno implantation (10 patients). In 11 patients who underwent second-stage Molteno implantation after trabeculectomy failure, 1- and 2-year life-table success rates were 79% and 79%, respectively. Complications included surgically treated choroidal effusions (1/45; 2%), choroidal hemorrhages (3/45; 7%), and chronic hypotony (3/45; 7%). Follow-up in all groups ranged from 5 to 70 months (mean +/- standard deviation, 28 +/- 17 months).


CONCLUSIONS
Trabeculectomy provides surprisingly good results in glaucomas associated with uveitis (modulation of wound healing with antimetabolites probably would afford an even higher success rate). However, when significant, immediate postoperative and/or moderate chronic postoperative inflammation is likely, aqueous drainage devices appear more likely to control IOP.
Department of Ophthalmology, University of California, Irvine College of Medicine 92717.
R A
RA
Hill
Q H
QH
Nguyen
G
G
Baerveldt
D J
DJ
Forster
D S
DS
Minckler
N
N
Rao
M
M
Lee
D K
DK
Heuer
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019736:Prostheses and Implants; D012189:Retrospective Studies; D012826:Silicone Elastomers; D014130:Trabeculectomy; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications / Q000601:surgery*
D012826:Silicone Elastomers