Environmental magnetic fields: influences on early embryogenesis.
A 10-mG, 50 to 60-Hz magnetic field is in the intensity and frequency range that people worldwide are often exposed to in homes and in the workplace. Studies about the effects of 50- to 100-Hz electromagnetic fields on various species of animal embryos (fish, chick, fly, sea urchin, rat, and mouse) indicate that early stages of embryonic development are responsive to fluctuating magnetic fields. Chick, sea urchin, and mouse embryos are responsive to magnetic field intensities of 10-100 mG. Results from studies on sea urchin embryos indicate that exposure to conditions of rotating 60-Hz magnetic fields, e.g., similar to those in our environment, interferes with cell proliferation at the morula stage in a manner dependent on field intensity. The cleavage stages, prior to the 64-cell stage, were not delayed by this rotating 60-Hz magnetic field suggesting that the ionic surges, DNA replication, and translational events essential for early cleavage stages were not significantly altered. Studies of histone synthesis in early sea urchin embryos indicated that the rotating 60-Hz magnetic field decreased zygotic expression of "early" histone genes at the morula stage and suggests that this decrease in early histone production was limiting to cell proliferation. Whether these comparative observations from animal development studies will be paralleled by results from studies of human embryogenesis, as suggested by some epidemiology studies, has yet to be established.
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
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Cameron
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Hardman
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Winters
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Zimmerman
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Zimmerman
D000818:Animals; D002642:Chick Embryo; D004261:DNA Replication; D004574:Electromagnetic Fields; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D004781:Environmental Exposure; D005306:Fertilization; D005786:Gene Expression Regulation; D006657:Histones / Q000096:biosynthesis; D006801:Humans; D008280:Magnetics; D051379:Mice / Q000196:embryology; D008938:Mitosis; D012617:Sea Urchins / Q000196:embryology
D006657:Histones