A study of Spanish sepiolite workers.
BACKGROUND
Sepiolite is an absorbent clay that is used as pet litter. It forms thin crystals, which are a transition between chain and layered silicates. Inhalation studies in animals have shown no evidence of pulmonary damage. This paper reports a cross sectional study of the total work force of the largest sepiolite production plant in the world.


METHODS
Two hundred and eighteen workers (210 men and eight women) were studied. Height, age, and smoking history were recorded. Chest radiographs were read according to the International Labour Office (ILO) classification by two readers. Readings were used to construct a numerical score, which was then used in statistical analyses. Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were divided by the square of the height. Casella size selective personal samplers were used in randomly selected operatives to collect dust eight years before the rest of the study was carried out. These samples were evaluated gravimetrically. Total dust samples were examined by optical and electron microscopes. Results were analysed by bivariate linear regression, chi 2 tests, and analysis of variance.


RESULTS
When allowance was made for smoking habit workers exposed to dry dust showed a significantly greater decline in FEV1 with age than workers with little exposure to dry dust. A similar pattern applied to FVC. Radiographic score showed deterioration with age but no clear differences from other variables. High concentrations of dust were found in the bagging department and also in the classifier shed.


CONCLUSIONS
The major finding was that lung function deteriorated more rapidly in those who had had more exposure to dust, but there was no evidence of any accompanying radiographic change.
Section of Respiratory Medicine, University of Wales College of Medicine, Llandough Hospital, Penarth, Glamorgan.
K
K
McConnochie
C
C
Bevan
R G
RG
Newcombe
J P
JP
Lyons
J W
JW
Skidmore
J C
JC
Wagner
D000328:Adult; D000367:Age Factors; D000863:Antacids / Q000009:adverse effects*; D001827:Body Height; D001835:Body Weight; D003430:Cross-Sectional Studies; D004391:Dust / Q000009:adverse effects; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008274:Magnesium / Q000009:adverse effects*; D017633:Magnesium Silicates; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011859:Radiography; D012824:Silicic Acid / Q000009:adverse effects*; D012907:Smoking; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D014797:Vital Capacity
D000863:Antacids; D004391:Dust; D017633:Magnesium Silicates; D012824:Silicic Acid; C001671:magnesium trisilicate; D008274:Magnesium