Systemic giant cell arteritis and cerebellar infarction.
OBJECTIVE
Systemic giant cell arteritis causing cerebellar infarction due to intracranial arteritis of the anterior inferior cerebellar artery has not been previously reported. We report this infrequent occurrence and discuss the differential diagnosis.


METHODS
An 85-year-old woman was admitted with a 2-week history of episodic ataxia, unilateral headaches, and vomiting. She had a history of atrial fibrillation and breast carcinoma. Her mental state was initially normal, and there were right-sided cerebellar signs. An ejection systolic murmur was heard, and peripheral pulses were palpable. A postmortem examination revealed cerebellar infarction due to giant cell arteritis of the anterior inferior cerebellar artery and basilar arteries. Systemic giant cell arteritis was also present.


CONCLUSIONS
Giant cell arteritis is a systemic disorder that can infrequently involve intracranial vessels, including the basilar, vertebral, and anterior cerebellar arteries. Cerebellar infarction secondary to the arteritis may occur. The distribution and size of intracranial vessel involvement is distinct from isolated cranial angiitis.
Department of Anatomical Pathology, Royal Melbourne Hospital, Victoria, Australia.
C A
CA
Mclean
M F
MF
Gonzales
J P
JP
Dowling
D000368:Aged; D001167:Arteritis / Q000150:complications* / Q000473:pathology; D001488:Basilar Artery / Q000473:pathology; D002531:Cerebellum / Q000098:blood supply; D002544:Cerebral Infarction / Q000209:etiology* / Q000473:pathology; D005260:Female; D015726:Giant Cells; D006337:Heart Murmurs / Q000150:complications; D006801:Humans; D011689:Purkinje Cells / Q000473:pathology