Trypanosoma vivax: evidence for only one RNA polymerase II largest subunit gene in a trypanosome which undergoes antigenic variation.
Previous studies suggested a correlation between antigenic variation in Kinetoplastida and the presence of two RNA polymerase (pol) II largest subunit genes in these organisms. We have found that Trypanosoma vivax, an African trypanosome which undergoes antigenic variation, is an exception, and has only one pol II largest subunit gene, indicating that probably neither of the two pol II genes found in other African trypanosomes is uniquely required for antigenic variation.
Intercampus Program in Molecular Parasitology, University of California, Berkeley.
J L
JL
Smith
A B
AB
Chapman
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N
Agabian
D000818:Animals; D000940:Antigenic Variation / Q000235:genetics*; D015139:Blotting, Southern; D016054:DNA, Protozoan / Q000032:analysis; D015870:Gene Expression; D017125:Genes, Protozoan; D005810:Multigene Family; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics*; D015183:Restriction Mapping; D017385:Sequence Homology; D014158:Transcription, Genetic; D016689:Trypanosoma vivax / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics
D016054:DNA, Protozoan; D014643:Variant Surface Glycoproteins, Trypanosoma; D012319:RNA Polymerase II