Long-term administration of probucol and QTc interval prolongation.
Electrocardiographic QTc intervals were measured in twenty-one hypercholesterolemic patients before and after long-term probucol (500-1,000 mg/day for 30 months) treatment. Probucol reduced serum total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C). Mean QTc interval prolongation after probucol was 17 msec. A positive correlation was found between the change in QTc interval after probucol (delta QTc) and the total amount of probucol administered. delta QTc was negatively correlated to the pre-treatment QTc interval. No correlation was observed between serum probucol concentrations and delta QTc. Neither clinical evidence of cardiotoxicity nor critical arrhythmias were noted during the treatment period.
Sasaki
N
N
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Saku
K
K
Moroe
K
K
Zhang
B
B
Hirata
K
K
Liu
R
R
Arakawa
K
K
D000368:Aged; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011341:Probucol / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D011341:Probucol