[Value of cytological study by flow cytometry or analysis of image as a complement to macroscopic study by cytoscopy. Apropos of therapeutic follow-up of a case of tumor of the bladder].
The case described corresponds to a grade G2 urothelial tumor with stage pTa extension (according to the World Health Organisation classification). After transurethral resection of the tumor and treatment by Bacillus Calmette Guerin (BCG), the efficacy of treatment was evaluated by cystoscopy, standard cytology, flow cytometry or image analysis. According to these various methods it has been shown that a normal cystoscopy may or may not be associated with aneuploidy revealed by flow cytometry. Such a case clearly illustrates the value of combining macroscopic examination and a cytologic analysis in particular by flow cytometry in order to increase the accuracy of diagnosis and to evaluate without ambiguity the efficacy of treatment.
Centre Commun de Cytofluorométrie, INSERM U80, Hôpital Edouard-Herriot, Lyon.
G
G
Lizard
L
L
Dusserre-Guion
P
P
Proignot
J C
JC
Tremeaux
F
F
Bejui-Thivolet
D001500:BCG Vaccine / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy
D001500:BCG Vaccine; D004273:DNA, Neoplasm
Intérêt de l'étude cytologique par cytométrie en flux ou analyse d'image en complément de l'examen macroscopique par cystoscopie. A propos du suivi thérapeutique d'un cas de tumeur de vessie.