Axonal loss in band atrophy of the optic nerve in craniopharyngioma: a quantitative analysis.
Automated image analysis was used to examine the optic nerves of a patient with previous craniopharyngioma and bitemporal hemianopsia. On histologic study the right optic nerve showed extensive damage, and the left optic nerve showed a band of damage horizontally across the nerve. Automated image analysis of the left nerve showed that the superior and inferior poles of the nerve had lost approximately 50% of their total nerve fibres, indicating that these areas contain a mixture of crossed and uncrossed fibres; the temporal portion showed a variable amount of loss. To our knowledge this is the first report illustrating quantitatively the pattern of axonal loss in this type of lesion.
Mikelberg
F S
FS
Department of Ophthalmology, University of British Columbia, Vancouver.
Yidegiligne
H M
HM
D000328:Adult; D001284:Atrophy; D001369:Axons / Q000473:pathology*; D002452:Cell Count; D003397:Craniopharyngioma / Q000150:complications / Q000473:pathology*; D006423:Hemianopsia / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D009900:Optic Nerve / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology*; D015354:Vision, Low / Q000209:etiology / Q000473:pathology; D014792:Visual Acuity; D014794:Visual Fields