Childhood intracranial meningiomas after high-dose irradiation.
BACKGROUND
Irradiation, either alone or in association with other factors, is thought to play a role in the causation of intracranial meningioma.


METHODS
The authors report two 15-year-old patients with convexity meningiomas as a result of high-dose irradiation received at a young age and review the English language literature reports of 13 pediatric patients with meningiomas after high-dose irradiation. The clinical characteristics of the 15 patients are presented.


RESULTS
There were nine girls and six boys. The mean age at the time of irradiation was 2.5 years (2 months-9 years), and the mean age at diagnosis of meningioma was 13 years (5-15.5 years). The mean radiation dose was 4154 cGy (1500-8000 cGy). In 11 of the 15 patients, the meningioma was located in the calvarial area. Only 1 of 15 had multiple tumors, and only two of the tumors were clearly malignant at diagnosis. In ten patients, gross total resection was recorded, and two patients underwent subtotal resection. Three died of recurrent/disseminated meningiomas.


CONCLUSIONS
This study suggests that meningiomas after high-dose radiation in children are mostly calvarial in location, rarely multiple, mostly benign in histologic type, and that complete removal is possible in most patients. The age at the time of radiation is young (mean age, 2.5 years) and the latent period is short (mean, 10.8 years). Although the clinical course of radiation-induced meningiomas in childhood generally is benign, high doses of radiation at a young age are to be avoided, and other means of therapy should be used if possible.
Ghim
T T
TT
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.
Seo
J J
JJ
O'Brien
M
M
Meacham
L
L
Crocker
I
I
Krawiecki
N
N
D001254:Astrocytoma / Q000532:radiotherapy; D001847:Bone Diseases / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000209:etiology / Q000532:radiotherapy; D005260:Female; D005625:Frontal Lobe / Q000528:radiation effects; D015614:Histiocytosis / Q000532:radiotherapy; D006801:Humans; D007223:Infant; D008297:Male; D008579:Meningioma / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010296:Parietal Lobe / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012536:Scalp Dermatoses / Q000532:radiotherapy; D012886:Skull / Q000528:radiation effects; D013786:Thalamic Diseases / Q000532:radiotherapy