Ketorolac and propofol administration for prevention of nausea and vomiting in patients undergoing minor gynecologic surgery.
This clinical review explores the efficacy of the nonsteroidal antiinflammatory agent, ketorolac tromethamine, added to an anesthetic regimen utilizing intravenous propofol. Both agents have been shown to reduce the incidence of nausea and vomiting postoperatively when administered to patients undergoing minor gynecologic surgery. Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain, it would appear to be an appropriate choice of agent to use following propofol anesthesia. The use of this combination of drugs may not only reduce the incidence of postoperative nausea and vomiting in patients undergoing minor gynecologic surgery, but could reduce the duration of hospitalization and enhance recovery from anesthesia.
Hough
M P
MP
Waugaman
W R
WR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D020911:Ketorolac Tromethamine; D009325:Nausea / Q000188:drug therapy*; D011183:Postoperative Complications / Q000188:drug therapy*; D011292:Premedication / Q000592:standards*; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014325:Tromethamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014839:Vomiting / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin; D015742:Propofol