Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3.
Proteinase-3 (PR3) is a polymorphonuclear leukocyte serine proteinase that is a potent inducer of emphysema in experimental models. PR3 is also the target antigen associated with Wegener's granulomatosis. By analysis of a panel of somatic cell hybrids, the gene encoding PR3 was localized previously to chromosome 19; we have used fluorescence in situ hybridization to sublocalize this gene to 19p13.3.
Sturrock
A B
AB
Department of Medicine, University of Utah, Salt Lake City 84132.
Espinosa
R
R
Hoidal
J R
JR
Le Beau
M M
MM
D001324:Autoantigens / Q000235:genetics; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D014890:Granulomatosis with Polyangiitis / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000235:genetics*
D001324:Autoantigens; D012697:Serine Endopeptidases; D053146:Myeloblastin