Prognosis for penetrating keratoplasty in iridocorneal endothelial syndrome.
BACKGROUND
Iridocorneal endothelial syndrome is characterized by the proliferation and spreading of an abnormal corneal endothelial membrane across the iridocorneal angle and iris surface, resulting in iridocorneal adhesions, glaucoma, pupillary distortion, varying degrees of iris atrophy, and occasionally corneal decomposition with edema. These changes may possibly affect the long-term prognosis of penetrating keratoplasty in an adverse fashion.


METHODS
We reviewed the clinical course of 12 consecutive eyes (12 patients) which underwent penetrating keratoplasty for corneal edema associated with the iridocorneal endothelial syndrome (mean postoperative follow up = 30 months).


RESULTS
The grafts remained clear in 10 patients (83%) and the visual acuity was 20/40 or better in nine patients (75%). The endothelial cell losses averaged 13% at 6 months and 17% at 1 year after surgery. Simultaneous extracapsular cataract extraction and posterior chamber lens implantation at the time of keratoplasty posed no measurable compromise to the overall postoperative prognosis. Causes of poor visual acuity after surgery included glaucoma and graft failure (immune and nonimmune).


CONCLUSIONS
The prognosis of penetrating keratoplasty in the iridocorneal endothelial syndrome appears to be very favorable in the majority of eyes.
Department of Ophthalmology, University of Michigan Medical Center, Ann Arbor 48105.
P C
PC
Chang
H K
HK
Soong
M F
MF
Couto
R F
RF
Meyer
A
A
Sugar
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D002452:Cell Count; D003316:Corneal Diseases / Q000601:surgery*; D015715:Corneal Edema / Q000601:surgery; D004728:Endothelium, Corneal / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007499:Iris Diseases / Q000601:surgery*; D015948:Keratoplasty, Penetrating; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013577:Syndrome; D014792:Visual Acuity