Soluble (s)CD23 levels in a parasitized population from Papua New Guinea.
Levels of sCD23, total and specific IgE were found to be considerably elevated in the plasma of a helminth infected population from Papua New Guinea. Using age-corrected data, a significant negative correlation was seen between sCD23 and total IgE in the young, at a time when hookworms are being rapidly acquired, and total IgE levels are rising most dramatically. It is suggested on the basis of this data that this inverse correlation is due to the stabilizing effect of IgE on the Fc epsilon RII receptor in vivo, and that the high levels of sCD23 seen in hookworm infected individuals are partly responsible for the high levels of IgE recorded in these patients.
Department of Life Science, Nottingham University, UK.
D I
DI
Pritchard
S
S
Kumar
P
P
Edmonds
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000918:Antibody Specificity; D000947:Antigens, Helminth / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006373:Helminthiasis / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D017221:Necator americanus / Q000276:immunology*; D009332:Necatoriasis / Q000276:immunology*; D010219:Papua New Guinea; D017455:Receptors, IgE / Q000032:analysis*
D000947:Antigens, Helminth; D017455:Receptors, IgE; D007073:Immunoglobulin E