Developmental expression of trkB and low-affinity NGF receptor in the rat retina.
Brain-derived neurotrophic factor (BDNF) promotes the survival of retinal ganglion cells, but these effects are dependent on the developmental stages, and a number of retinal ganglion cells are eliminated during pre- and neonatal stages. We have examined the expression of BDNF receptors, trkB and low-affinity nerve growth factor receptor (LNGFR), in the rat retina during these period using Northern blot analysis. The expression of trkB and LNGFR displayed two peaks during embryonic day 17 (E17) through postnatal day 1 (P1), and during P14-P17, indicating that it may play an important role in neuronal development and neuronal cell death.
Department of Viral Oncology, Kyoto University, Japan.
J B
JB
Takahashi
M
M
Hoshimaru
H
H
Kikuchi
M
M
Hatanaka
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D016923:Cell Death / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D008969:Molecular Sequence Data; D051381:Rats; D017208:Rats, Wistar; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D012160:Retina / Q000254:growth & development / Q000378:metabolism*
D017475:Receptors, Nerve Growth Factor