Comparison of anti-human and anti-porcine factor VIII inhibitor levels in 63 patients with severe haemophilia A. A French Multicentric Study.
The levels of anti-human and anti-porcine factor VIII inhibitors, measured in 63 severe haemophilia A patients, lay in the ranges of < 0.2-2,600 and < 0.2-1,300 Bethesda units per ml (BU/ml), respectively, with a median cross-reactivity of 33%. In 4 patients, human and porcine inhibitor levels were determined using both plasma, either human or porcine, and factor VIII concentrate, either very high purity human or porcine (Hyate:C). A good correlation between titres was found, whatever the source of factor VIII (plasma or concentrate). The cross-reactivity varies from 0 to over 100%, indicating that the evaluation of both human and porcine inhibitors should be mandatory before any treatment with Hyate:C. Results show that of the 46 patients with human inhibitor of more than 5 BU/ml, 21 (46%) with a low porcine inhibitor (< 5 BU/ml) could benefit from Hyate:C.
Haemophilia Centres, Nantes, France.
M
M
Fiks-Sigaud
L
L
Bendelac
A
A
Parquet
F
F
Verroust
M F
MF
Torchet
A M
AM
Berthier
E
E
Fressinaud
C
C
Guerois
M F
MF
Aillaud
B
B
Boneu
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D003429:Cross Reactions; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000097:blood / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D013552:Swine / Q000276:immunology*
D001323:Autoantibodies; D007518:Isoantibodies; D005169:Factor VIII