Timing of replication of beta satellite repeats of human chromosomes.
The beta satellite sequences of the human genome are a family of genetic elements consisting of 68-69 bp monomeric units repeated contiguously in long arrays up to 1 Mb in length. We have determined the timing of replication of beta satellite subgroups located in the heterochromatic portion of chromosome 9 and on the acrocentric chromosomes in regions both distal and proximal to the rDNA genes. We report that these dispersed subgroups of beta satellite sequences all replicate late during S phase of the cell cycle.
Department of Genetics, Stanford University School of Medicine, CA 94305-5120.
K G
KG
Ten Hagen
S N
SN
Cohen
D015139:Blotting, Southern; D002460:Cell Line; D002877:Chromosomes, Human / Q000378:metabolism*; D004261:DNA Replication; D004276:DNA, Satellite / Q000096:biosynthesis*; D006801:Humans; D012091:Repetitive Sequences, Nucleic Acid; D016196:S Phase
D004276:DNA, Satellite