Factor V inhibitor in thrombosis.
A 68-year-old previously well woman developed sudden onset of limb gangrene in association with liver dysfunction. An immediately acting inhibitor to factor V with some of the features of lupus anticoagulant was demonstrated. The patient required limb amputation within 2 weeks and activity of the anticoagulant seemed to be on the decline 6 months later.
Department of Medicine, Victoria Hospital, Blackpool, Lancashire, United Kingdom.
A
A
Kapur
P R
PR
Kelsey
P E
PE
Isaacs
D000368:Aged; D000671:Amputation, Surgical; D001780:Blood Coagulation Tests; D005165:Factor V / Q000037:antagonists & inhibitors*; D005260:Female; D005734:Gangrene; D006801:Humans; D007866:Leg / Q000473:pathology; D013927:Thrombosis / Q000097:blood* / Q000473:pathology
D005165:Factor V