Atrazine in plasma and tissue following atrazine-aminotriazole-ethylene glycol-formaldehyde poisoning.
A high performance liquid chromatography method has been used to study the plasma kinetics of atrazine in a human fatality after ingestion of a herbicide mix containing atrazine, aminotriazole, ethylene glycol and formaldehyde. A hemodialysis was performed in an effort to eliminate these toxic substances. The mean atrazine clearance over 4 h was 250 mL/min and the dialysance of atrazine was calculated as 76%. On autopsy, the kidney showed the highest concentration of atrazine (97.62 micrograms/g-1 wet tissue) with lesser concentrations in the lung, small intestine and liver, and the lowest concentration in the heart.
Laboratoire de Toxicologic, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France.
J
J
Pommery
M
M
Mathieu
D
D
Mathieu
M
M
Lhermitte
D000328:Adult; D000640:Amitrole / Q000506:poisoning*; D000818:Animals; D001280:Atrazine / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning; D002851:Chromatography, High Pressure Liquid; D005026:Ethylene Glycols / Q000506:poisoning*; D005557:Formaldehyde / Q000506:poisoning*; D005751:Gastric Lavage; D006439:Hemodynamics / Q000187:drug effects; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D017208:Rats, Wistar; D006435:Renal Dialysis; D014018:Tissue Distribution
D005026:Ethylene Glycols; D006540:Herbicides; D005557:Formaldehyde; D001280:Atrazine; D000640:Amitrole