Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients.
Serum thyroid hormone and thyrotropin levels were assayed and the myocardial function was evaluated by measuring systolic time intervals both in 30 patients with epilepsy on long-term carbamazepine monotherapy and in 19 healthy volunteers. Serum thyroxine, free thyroxine and triiodothyronine levels were significantly lower (p < 0.001) in the patient group than in the control group and systolic time intervals were similar in both groups.
Department of Neurology, University of Oulu, Finland.
J I
JI
Isojärvi
K E
KE
Airaksinen
M
M
Repo
A J
AJ
Pakarinen
P
P
Salmela
V V
VV
Myllylä
D000328:Adult; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D013599:Systole / Q000502:physiology; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D002220:Carbamazepine; D013974:Thyroxine