Inhibition of crystallins-induced inflammation in rabbit eyes with five phytogenic compounds.
Ocular inflammation was induced by injection of crystallins (lens protein) intracamerally and endotoxin intravitreously into rabbit and rat eyes, respectively, and was measured with fluorophotometry by quantitating the amount of fluorescein which entered into the globe. Five compounds isolated from anti-inflammatory Chinese herbs were studied for their effects on ocular inflammation. It was found that lens protein-induced inflammation was inhibited significantly by the topical instillation of pulegone (0.5%), friedelin (0.5%), and sabinene (1%), but not by dihydrojasmon or naringin at concentrations up to 1%. However, none of these compounds inhibited endotoxin-induced posterior uveitis.
Institute of Ocular Pharmacology, College of Medicine, Texas A&M University, College Station 77843-1114.
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Yao
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Chiou
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003459:Crystallins; D000081005:Cyclohexane Monoterpenes; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000139:chemically induced / Q000188:drug therapy*; D004731:Endotoxins; D005260:Female; D044950:Flavanones; D005419:Flavonoids / Q000627:therapeutic use; D008297:Male; D008610:Menthol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D039821:Monoterpenes; D009883:Ophthalmic Solutions; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000627:therapeutic use*; D015866:Uveitis, Posterior / Q000139:chemically induced / Q000188:drug therapy*; D000094042:Lupanes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003459:Crystallins; D000081005:Cyclohexane Monoterpenes; D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D044950:Flavanones; D005419:Flavonoids; D008610:Menthol; D039821:Monoterpenes; D009883:Ophthalmic Solutions; D014315:Triterpenes; C039648:pulegone; C060796:friedelin; D000094042:Lupanes; C005274:naringin