Amyloid beta protein precursor accumulates in swollen neurites throughout rat brain with aging.
We immunocytochemically studied the expression of amyloid beta protein precursor (APP) in the brains of normal aged rats, and found APP accumulation in swollen neurites, most of which were axons. These swollen neurites appeared throughout the central nervous system of aged rats; most of them were negative for neurofilament, ubiquitin, and tau. Such widely distributed APP accumulation in swollen neurites may reflect impaired fast axonal transport due to aging. APP immunostaining may be a good method to detect widely distributed age-related changes.
Department of Neurology, Gunma University School of Medicine, Japan.
T
T
Kawarabayashi
M
M
Shoji
H
H
Yamaguchi
M
M
Tanaka
Y
Y
Harigaya
K
K
Ishiguro
S
S
Hirai
D000375:Aging / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D007275:Injections, Intravenous; D016501:Neurites / Q000378:metabolism* / Q000648:ultrastructure; D009498:Neurotoxins / Q000494:pharmacology; D009570:Nitriles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014018:Tissue Distribution
D016564:Amyloid beta-Protein Precursor; D009498:Neurotoxins; D009570:Nitriles; C008110:3,3'-iminodipropionitrile