Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.
We have conducted a detailed structural analysis of 90 kilobases (kb) of the HLA Class III region from the Bat2 gene at the centromeric end to 23 kb beyond TNF. A single contig of 80 kb was sequenced entirely with a group of four smaller contigs covering 10 kb being only partly sequenced. This region contains four known genes and a novel telomeric potential coding region. The genes are bracketed by long, dense clusters of Alu repeats belonging to all the major families. At least six new families of MER repeats and one pseudogene are intercalated within and between the Alu clusters. The most telomeric 3.8 kb contains three potential exons, one of which bears strong homology to the ankyrin domain of the DNA binding factors NF kappa B and I kappa B.
Centre d'Etude du Polymorphisme Humain, Paris, France.
F J
FJ
Iris
L
L
Bougueleret
S
S
Prieur
D
D
Caterina
G
G
Primas
V
V
Perrot
J
J
Jurka
P
P
Rodriguez-Tome
J M
JM
Claverie
J
J
Dausset
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D016328:NF-kappa B / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D006680:HLA Antigens; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D004247:DNA