Sino-nasal adenocarcinoma: epidemiological and clinico-pathological study of 34 cases.
Thirty-four cases of sino-nasal adenocarcinoma treated between 1976 and 1992 are presented. The purpose of this work is the epidemiological analysis of this disease and to put forward a classification of the lesions according to their degree of differentiation, based on the histopathological examination of 29 tumors. The risk increase of having a sino-nasal neoplasia was significant in the population exposed to wood dust in their working environment--896 times greater (540 in the male population) for adenocarcinoma and 20 times greater for squamous-cell adenocarcinoma. The proposed histopathological classification divides these lesions according to their degree of differentiation. In this series 23 well-differentiated cases were found, three moderately differentiated and three colloid-type. The five-year determinate survival of this series was 30%. The tumor stage (especially intracranial involvement) was the only significant clinico-pathological parameter that impaired the survival.
Ear, Nose and Throat Department and the Department of Histopathology, Hospital Central de Asturias, Oviedo, Spain.
F
F
Nuñez
C
C
Suarez
I
I
Alvarez
J L
JL
Losa
P
P
Barthe
M
M
Fresno
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology; D004391:Dust / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D009784:Occupational Diseases / Q000453:epidemiology / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D014934:Wood
D004391:Dust