[The role of eosinophil chemotactic factor in localized tissue eosinophilia by parasitic infection].
Eosinophil chemotactic factors (ECFs) are thought to play an important role in the recruitment of eosinophils to parasitic inflammatory regions. ECF-A derived from mast cells, lymphokines from lymphocytes and ECFs from complements are well known as host-derived ECFs. On the other hand, ECF from parasites (ECF-P) and cytokines such as ESP (eosinophil stimulation promoter) and interleukin-5 are reported to be responsible for the eosinophil accumulation in parasitic inflammatory regions. In a series of our experiments using Anisakis larvae, we discovered a mechanism of eosinophil recruitment which could be accelerated by priming with ECF-P in parasite infected eosinophil phlegmon.
Surgery I, Faculty of Medicine, Kyushu University.
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Ishimitsu
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Torisu
D000818:Animals; D002631:Chemotactic Factors, Eosinophil / Q000378:metabolism / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism / Q000502:physiology; D004802:Eosinophilia; D004803:Eosinophilic Granuloma / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism; D010272:Parasitic Diseases / Q000378:metabolism* / Q000473:pathology
D002631:Chemotactic Factors, Eosinophil; D016207:Cytokines