[Validation and clinical and epidemiological use of a serologic test recommended in the diagnosis of Helicobacter pylori infection].
A commercial serologic test using purified antigens of Helicobacter pylori has been evaluated in the diagnosis of this infection. In a series of 250 patients undergoing endoscopy with antral biopsies for cytology, histology and culture, serology was positive in 68 of 71 patients with a positive culture (sensitivity: 96%) and negative in 67 of 69 patients with a normal mucosa and no microorganisms on biopsy (specificity: 97%). In the entire series, serology was positive in 33 patients with no infection on biopsies (13%). In a group of 205 blood donors, we confirmed an increasing prevalence with age, ranging from 13% in subjects less than 30 years old to 38% in subjects more than 60 years old.
Debongnie
J C
JC
Service de Gastroentérologie, Clinique St-Pierre, Ottignies, Belgique.
Durez
P
P
Luyasu
V
V
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial; D001706:Biopsy; D016145:Endoscopy, Digestive System; D005260:Female; D005602:France / Q000453:epidemiology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007158:Immunologic Techniques; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D000907:Antibodies, Bacterial
Validation et usage clinique et épidémiologique d'un test sérologique commercialsié dans le diagnostic de l'infection à Helicobacter pylori.