[Significance of plasma interleukin-6 in the diagnosis of renal cell carcinoma].
The significance of interleukin-6 (IL-6) in the diagnosis of renal cell carcinoma (RCC) was investigated. In RCC patients, we found that, even when IL-6 was produced by RCC, the plasma level of IL-6 was under the limit of detection in almost all patients with a classification of T2N0M0 or lower. In the case of rapidly progressive type of bulky metastasis, the concentration of IL-6 in plasma was high, but the IL-6 level correlated well with the serum C-reactive protein (CRP) level. These findings suggest that IL-6 has little potential to serve as a new tumor marker for RCC.
Department of Urology, Nagasaki University School of Medicine.
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Kamemoto
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007680:Kidney Neoplasms / Q000097:blood / Q000175:diagnosis*; D008297:Male; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D015850:Interleukin-6; D002097:C-Reactive Protein