[The effect of long-term prazosin treatment on plasma follitropin (FSH), lutropin (LH), prolactin, estradiol and testosterone concentration in male patients with essential hypertension].
The influence of prazosin treatment for 12 months on basal and LH-RH stimulated FSH, LH, estradiol and testosterone secretion and basal and chlorpromazine stimulated prolactin secretion was estimated in 15 male patients with essential hypertension. Male hypertensive patients were characterized by significantly elevated FSH and reduced testosterone secretion as compared with controls. In contrast, plasma LH, prolactin and estradiol concentrations were similar in both examined groups. After 12 months of prazosin treatment basal and stimulated LH and prolactin secretion significantly decreased while estradiol secretion significantly increased. Prazosin treatment for 12 months did not influence significantly LH and testosterone secretion.


CONCLUSIONS
1. Data presented in this study suggest the presence of abnormal function of the pituitary--gonadal axis in male patients with essential hypertension. 2. Long-term prazosin treatment shows an inhibitory effect on FSH and prolactin secretion but stimulatory one on estrogens secretion in male hypertensive patients.
Wiecek
A
A
Katedry i Kliniki Nefrologii Sl. AM w Katowicach.
Kokot
F
F
Zukowska-Szczechowska
E
E
D000328:Adult; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use*; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood
D006728:Hormones; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011224:Prazosin
Wpływ długotrwałego podawania prazosyny na stezenie folitropiny (FSH), lutropiny (LH), prolaktyny, estradiolu oraz testosteronu u mezczyzn chorych na samoistne nadciśnienie tetnicze.