Oncogenes and tumor suppressor genes.
Molecular oncologists are elucidating the genetic mechanisms by which cancer cells proliferate. Prominent examples among dominant oncogenes include members of the ras family, which are activated by point mutations that perpetuate transduction of growth signals. The best-studied tumor suppressor gene is p53, which appears to be involved in the repair of damaged DNA.
Carbone
D P
DP
University of Texas Southwestern Medical Center, Dallas.
D015984:Causality; D004249:DNA Damage / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008957:Models, Genetic; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D009857:Oncogenes / Q000235:genetics* / Q000502:physiology; D015996:Survival Rate