[Amylin: its potential role in the etiopathogenicity of diabetes mellitus].
The recent discovery that IAPP, or amylin, a polypeptide solubilized from the amyloid substance found in the islets of Langerhans of most type II diabetics, is secreted along with insulin by beta cells and possesses anti-insulinic effects has opened new perspectives in the etiopathogenesis of this type of diabetes. Many data suggest a possible hormonal mechanism acting on perypheral targets, though so far effects have only been observed with supraphysiological doses. Other reports suggest amylin would have a deleterious effect on beta cells, because of its deposition in the form islet amyloid.
Servicio de Endocrinología, Hospital General Gregorio Marañón, Madrid.
E
E
Artozqui Morrás
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M
Botella Serrano
M
M
Camblor
I
I
Bretón Lesmes
B
B
Moreno Esteban
D000595:Amino Acid Sequence; D000682:Amyloid / Q000502:physiology*; D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008969:Molecular Sequence Data
D000682:Amyloid; D058228:Islet Amyloid Polypeptide
Amilina: su posible papel en la etiopatogenia de la diabetes mellitus.