Multisection proton MR spectroscopic imaging of the brain.
The authors developed a hydrogen-1 proton magnetic resonance (MR) imaging method in which metabolic information is acquired by obtaining multiple sections through the brain. A spin-echo sequence is used for section selection, an octangular outer volume saturation pulse for lipid suppression, and a chemical-shift-selective saturation pulse for water suppression. High-quality maps of choline, creatine, and N-acetylaspartate were obtained in six studies performed in four volunteers. Water and lipid signal from the skull area was well suppressed by the pulse sequence used.
Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892.
J H
JH
Duyn
J
J
Gillen
G
G
Sobering
P C
PC
van Zijl
C T
CT
Moonen
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D008055:Lipids; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D014867:Water
D008055:Lipids; D014867:Water; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline