Effects of H-2 and dietary vitamin A on the frequency of dorsoventral vaginal septum.
The frequency of dorsoventral vaginal septum (DVS) in mice is determined in part by genes associated with the major histocompatibility complex H-2. Data presented here confirm that one locus (DVS-1) maps centromeric to E alpha and that the second (DVS-2), previously shown to be associated with the S-to-D region, maps to the C4:B144 interval, most likely between Dcp-2 which contributes to glucocorticoid-induced cleft palate susceptibility and Acp which enhances cleft palate susceptibility through the action of vitamin A. Comparisons of data obtained in this laboratory in the periods 1981-1983 and 1985-1990 and observations from the production colony from which many of the strains were purchased revealed minor variations in frequencies of DVS within strains which may be due to differences in ascertainment and/or to environmental factors. The addition of vitamin A to the diet of pregnant mice at a dose that increases the frequency of cleft palate in susceptible strains had no effect on the incidence of DVS.
West Los Angeles Veterans Affairs Medical Center, California 90073.
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D000483:Alleles; D000818:Animals; D002972:Cleft Palate / Q000235:genetics; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D014621:Vagina / Q000002:abnormalities*; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*
D006183:H-2 Antigens; D014801:Vitamin A