Psychiatric diagnosis and the surgical outcome of pancreas transplantation in patients with type I diabetes mellitus.
To examine the role of psychiatric diagnosis in the surgical outcome of pancreas transplantation, we studied candidates with type I diabetes mellitus. Eighty of 140 candidates underwent transplantation. Survival analysis found the extent of human leukocyte antigen-DR (HLA-DR) matching, two diagnoses, and patients' perceived support from first-degree relatives to be related to duration of full-graft function. Lifetime diagnoses of tobacco use disorder (P = 0.029) and alcohol abuse/dependence (P = 0.006) were associated with less favorable outcomes; perceived support was associated with positive outcomes (P = 0.048). Subsequent analysis suggested that the four variables independently and directly affect outcome.
Popkin
M K
MK
Department of Psychiatry, University of Minnesota Medical School, Minneapolis.
Callies
A L
AL
Colón
E A
EA
Lentz
R D
RD
Sutherland
D E
DE
D000223:Adaptation, Psychological; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000523:psychology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000523:psychology; D016035:Pancreas Transplantation / Q000523:psychology*; D011183:Postoperative Complications / Q000523:psychology*; D012803:Sick Role; D012944:Social Support