Synthesis of beta-hematin by dehydrohalogenation of hemin.
beta-Hematin, the metalloporphyrin coordination polymer present in malaria pigment, is prepared in high yield by the abstraction of HCl from hemin with a non-coordinating base in strictly anhydrous conditions. The product of this preparation is characterized by elemental analysis, infrared and diffuse reflectance spectroscopies and demonstrated to be identical to prior preparations.
Bohle
D S
DS
Department of Chemistry, University of Wyoming, Laramie 82071-3838.
Helms
J B
JB
D000818:Animals; D002417:Cattle; D006427:Hemin / Q000737:chemistry*; D007202:Indicators and Reagents; D013053:Spectrophotometry
D007202:Indicators and Reagents; D006427:Hemin