Hydroquinone simultaneously induces indole amine 2,3 dioxygenase (IOD) and inhibits tyrosinase in Bufo melanostictus.
Hydroquinone administration in Bufo melanostictus causes an induction of indole amine 2,3-dioxygenase in skin and liver while simultaneously inhibiting tyrosinase in these organs. The result is discussed with the reports of higher urinary excretion of abnormal indole metabolites including derivatives of anthranilic acid in vitiliginous subjects (Roychoudhury and Chakraborty, Clinica. Chim. Acta 22, 298, 1968; Kurbanov and Berezov, Vopr. Med. Khim. 22, 683, 1976).
Department of Chemistry, Bose Institute, Calcutta, India.
A K
AK
Chakraborty
A
A
Chakraborty
D P
DP
Chakraborty
D000818:Animals; D002025:Bufonidae; D004790:Enzyme Induction; D006873:Hydroquinones / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D012867:Skin / Q000187:drug effects / Q000201:enzymology; D014366:Tryptophan Oxygenase / Q000096:biosynthesis* / Q000187:drug effects
D006873:Hydroquinones; D014366:Tryptophan Oxygenase; D014442:Monophenol Monooxygenase; C031927:hydroquinone