[The quality of conceptus as a function of father's age].
Testicular ageing affects at the same time the individual and his lineage. In the individual, vascular, endocrine, blood testis barrier and Sertoli cells changes because of age lead a decrease of spermatozoa number and an alteration in their form and motility. These changes lead a gradual decrease of fertility. In the progeny, paternal ageing is responsible for new dominant autosomic mutations which themselves cause different malformations and perhaps for certain chromosome X linked recessive mutations. Moreover, in animal and man, paternal ageing seems responsible for a gradual lowering in the level of progeny cerebral functions. In man, very youthful age was also related to these effects. Maternal age did not appear to play a part in this event. On the whole, these results pose the problem of the optimum age for fatherhood.
Auroux
M
M
Biologie de la Reproduction et du Développement, CHU Bicêtre, Le Kremlin-Bicêtre.
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D005298:Fertility / Q000502:physiology*; D006801:Humans; D007985:Leydig Cells / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000235:genetics; D010331:Paternal Age; D012671:Seminiferous Tubules / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology; D013733:Testicular Diseases / Q000209:etiology / Q000235:genetics
La qualité du conceptus en fonction de l'âge du père.