[Lipid metabolism in daunomycin-induced nephrotic rats (Part 6)].
Lipid metabolism in tissues and HDL were examined in daunomycin-induced nephrotic rats. 1) Daunomycin-induced nephrotic rats showed the decreased phospholipids, the increased cholesterol content in heart. Phospholipids, triglycerides and cholesterol content in brain, lung and spleen were similar in daunomycin-induced nephrotic rats and control rats. 2) Triglycerides content in hepatocytes was decreased in daunomycin-induced nephrotic rats. But, cholesterol esters content in hepatocytes was higher in daunomycin-induced nephrotic rats than control rats. 3) LCAT activity in serum was increased in daunomycin-induced nephrotic rats. 4) Apolipoproteins composition of HDL in daunomycin-induced nephrotic rats showed the increased apoA-I and the decreased apo E. These results show that the increased cholesterol esters in liver tissue are due to hepatocytes in daunomycin-induced nephrotic rats. The increased HDL cholesterol content may contribute to the increase of LCAT activity in daunomycin-induced nephrotic rats. The increase of LCAT activity in serum results in the increased apo A-I content in daunomycin-induced nephrotic rats. No direct evidence about the incorporation of HDL into liver is obtained from the present experiments and further study will be necessary to clarify this evidence.
Gomikawa
S
S
Renal and Dialysis Unit, Hyogo College of Medicine, Nishinomiya, Japan.
Inagaki
O
O
Mori
H
H
Inoue
S
S
Takamitsu
Y
Y
Fujita
Y
Y
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D003630:Daunorubicin / Q000009:adverse effects* / Q000493:pharmacokinetics; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014280:Triglycerides / Q000378:metabolism
D008076:Cholesterol, HDL; D014280:Triglycerides; D003630:Daunorubicin