Kinetics of trichloroethylene elimination from venous blood after acute inhalation poisoning.
The kinetics of trichloroethylene were examined in three men, 28-36 years old, hospitalized after an acute occupational exposure. The trichloroethylene concentration of venous blood was determined by gas chromatography with headspace analysis; urinary trichloroacetic acid was assayed by the colorimetric method of Fujiwara. The kinetics of blood trichlorethylene (t1/2 21.7 h) and the urinary elimination of trichloracetic acid over six days were used to calculate the total inhalation exposures. Blood trichlorethylene was diagnostically more relevant than urinary trichloracetic acid.
Department of Toxic Substances Metabolism, Institute of Occupational Medicine, Lódź, Poland.
P
P
Kostrzewski
M
M
Jakubowski
Z
Z
Kołaciński
D000280:Administration, Inhalation; D000328:Adult; D002849:Chromatography, Gas; D006207:Half-Life; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D014238:Trichloroacetic Acid / Q000652:urine; D014241:Trichloroethylene / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*
D014241:Trichloroethylene; D014238:Trichloroacetic Acid