Human follicular fluid from pre-ovulatory follicles in patients undergoing in-vitro fertilization inhibits the in-vitro growth of gram-positive micro-organisms.
In this study, we assessed the antibacterial activity of human follicular fluid obtained from patients undergoing oocyte aspiration for in-vitro fertilization and embryo transfer. Gram-positive and Gram-negative microorganisms and Candida albicans were added to the follicular fluid and broth cultures which served as controls. Follicular fluid was shown to be inhibitory against Gram-positive microorganisms; this inhibition was probably due to lysosyme and progesterone. Growth of Gram-negative micro-organisms and C. albicans were, however, supported by follicular fluid incubation.
Gürgan
T
T
Department of Obstetrics and Gynaecology, University of Hacettepe, Faculty of Medicine, Ankara, Turkey.
Urman
B
B
Diker
K S
KS
Delilbasi
L
L
Kisnisci
H A
HA
D002176:Candida albicans / Q000254:growth & development; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000502:physiology*; D005498:Follicular Phase; D006090:Gram-Negative Bacteria / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000254:growth & development*; D006801:Humans