Hypertension and atherosclerosis in the elderly: pathogenetic common mechanism and intervention strategies.
Hypertension is the leading cause of death in the elderly in Western countries. The Authors remark that hypertension is not only a purely hemodynamic phenomenon, but is a multifaceted disease frequently associated with metabolic disorders in the elderly. Among the latter, hyperinsulinism could be the linking pathogenetic factor with atherosclerosis progression. Then the Authors suggest a unitary pathogenetic hypothesis of hypertension and atherosclerosis. The crucial points are the inborn alteration of cellular sodium transport systems and the modulating action of environmental factors, first of all insulin. According to this hypothesis, the goal of the management of elderly hypertensives is the prevention of the fatal or invalidant cerebro- and cardiovascular event. To follow a good "pathogenetic" treatment of elderly hypertension and atherosclerotic process evolution, the first step is a dietetic approach avoiding acute load of sodium and lipids. Furthermore, the pharmacological treatment with calcium antagonists and ACE inhibitors is respectful of associated metabolic disorder and positively modulate the cellular sodium transport systems activity.
Marigliano
V
V
Cattedra Gerontologia e geriatria, Università di Roma La Sapienza, Policlinico Umberto I, Italy.
Scuteri
A
A
Cacciafesta
M
M
Bellucci
C R
CR
Di Bernardo
M G
MG
De Propris
A M
AM
Del Foco
C
C
Bagaglini
E
E
D000368:Aged; D000375:Aging / Q000502:physiology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000628:therapy*; D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000628:therapy*; D012307:Risk Factors; D012964:Sodium / Q000502:physiology
D012964:Sodium