Corresponding type-specificity of vibriocidal and agglutinating activities of Vibrio cholerae antisera: relevance to vaccine immunogenicity.
Cholera vibrios can be allocated to one of three biotypes (classical, intermediate and El Tor), each of which can be sub-divided into two serotypes (Ogawa and Inaba). Vibriocidal tests with absorbed  antisera have shown no evidence of biotype specificity in the killing of bacteria, but they have confirmed the role of the two serotype-specific antigens in immunity to cholera. The same presence of serotype specificity, and absence of biotype specificity, has been found by bacterial agglutination, an easier and quicker serological test. The use of this simpler test in ensuring a balanced serotype response to cholera vaccine is discussed, together with evidence that may lead to the production of more effective vaccine and better immunity.
Department of Medical Microbiology, University Medical School, Manchester.
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Preston
D000371:Agglutination / Q000276:immunology; D015373:Bacterial Typing Techniques; D022121:Cholera Vaccines / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D013045:Species Specificity; D014734:Vibrio cholerae / Q000145:classification / Q000276:immunology*
D022121:Cholera Vaccines; D007106:Immune Sera