Pharmacokinetics of dapsone in children.
We studied dapsone pharmacokinetics in eight children with compromised immune function who were receiving three different preparations. Peak serum concentration was less than 0.25 microgram/ml after doses of an extemporaneous liquid preparation but ranged from 0.72 to 1.33 micrograms/ml after initial tablet or proprietary liquid doses and 1.48 to 2.48 microgram/ml during long-term proprietary liquid administration. Elimination followed first-order kinetics; the mean elimination half-life was 15.1 hours.
Mirochnick
M
M
Department of Pediatrics, Boston City Hospital, Massachusetts 02118.
Michaels
M
M
Clarke
D
D
Breña
A
A
Regan
A M
AM
Pelton
S
S
D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D003622:Dapsone / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male
D003622:Dapsone