Antifertility effects in female rats immunized with human seminal plasma inhibin.
Adult female rats were actively immunized with sperm-coating protein (10.4 KDa) human seminal plasma inhibin (HSPI). Following 8 weeks of immunization at 2.5 micrograms and 5 micrograms doses of HSPI with Freund's complete adjuvant, antifertility effects were observed in 63% (5/8) and 88% (7/8) of animals, respectively. Estrous cycle was not affected in experimental group. Thus, the present study suggests the potential use of HSPI for immunocontraception in females.
Hurkadli
K S
KS
Institute for Research in Reproduction (ICMR), Parel Bombay, India.
Vernekar
V J
VJ
Sheth
A R
AR
D000818:Animals; D000917:Antibody Formation; D003269:Contraception, Immunologic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000276:immunology / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D012661:Semen / Q000737:chemistry; D014611:Vaccination
D007265:Inhibins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone