Comparison of cerebrospinal fluid pressure in propofol- and thiopental-anesthetized eucapnic dogs.
Cerebrospinal fluid pressure (CSFp) was measured as part of the neurologic assessment of dogs with suspected intracranial disease. Because propofol has not been shown to cause an increase in intracranial pressure in humans, the authors examined its effect on (CSFp) in dogs to determine if it would be an appropriate substitute for thiopental as an anesthetic agent for the measurement of CSFp. The CSF pressure in eucapnic propofol-anesthetized dogs (105 +/- 5.6 mm H2O) was not significantly different (p < .05) from CSFp in eucapnic thiopental-anesthetized dogs (103.8 +/- 6.6 mm H2O).
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
T L
TL
Wooten
C T
CT
Lowrie
D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects*; D004285:Dogs / Q000097:blood / Q000134:cerebrospinal fluid* / Q000601:surgery; D005260:Female; D008297:Male; D015742:Propofol / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*
D002245:Carbon Dioxide; D013874:Thiopental; D015742:Propofol