Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study.
Striatal dopamine D1 receptors were investigated in 11 patients with Parkinson's disease (PD), five patients with striatonigral degeneration (SND) and six age-matched controls by positron emission tomography and carbon-11 labelled SCH23390. The SND patients showed mean 12%, 21%, and 31% declines in the ratios of radioactivity in the caudate, anterior putamen, and posterior putamen compared with that in the occipital cortex. These ratios were not significantly altered in the PD patients. The results may explain the different therapeutic responses to levadopa between SND and PD patients, and this technique might prove useful for their differentiation.
Shinotoh
H
H
Department of Neurology, School of Medicine, Chiba University, Japan.
Inoue
O
O
Hirayama
K
K
Aotsuka
A
A
Asahina
M
M
Suhara
T
T
Yamazaki
T
T
Tateno
Y
Y
D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology*; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology*; D003342:Corpus Striatum / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D011699:Putamen / Q000503:physiopathology; D011859:Radiography; D017447:Receptors, Dopamine D1; D014055:Tomography, Emission-Computed / Q000379:methods*
D017447:Receptors, Dopamine D1; D007980:Levodopa