[The circulatory and respiratory effects of methylprednisolone associated with catecholamine administration of a few hours].
We studied the circulatory and respiratory effects of methylprednisolone (MPS) associated with catecholamine administration of a few hours after cardiopulmonary bypass (CPB). Forty patients undergoing coronary artery bypass grafting were randomly divided into two groups. Twenty patients in group 1 [MPS (-) group] did not receive MPS and 20 patients in group 2 [MPS (+) group] received MPS 15 mg.kg-1 i.v. 60 minutes after CPB. The circulatory and respiratory parameters were measured 60 minutes after CPB, 30 minutes after MPS i.v. and 60 minutes after MPS i.v. The values in MPS (-) group were compared with those in MPS (+) group. CI and SVI decreased, and SVRI and PQR increased in MPS (-) group, but these values were unchanged in MPS (+) group. RAP, mPAP, PCWP and PVRI were unchanged in MPS (-) group. PCWP increased and the other values were unchanged in MPS (+) group. The blood gases and pulmonary alveolar function were not different between the two groups. The oxygen delivery decreased in MPS (-) group, but it was unchanged in MPS (+) group. The oxygen consumption was unchanged in the two groups. Blood cortisol increased and epinephrine and norepinephrine decreased in MPS (+) group. Methylprednisolone had an effect to improve the decreased CI and the increased SVRI, and no respiratory problems were observed in patients for coronary artery bypass grafting with catecholamine administration for a few hours after cardiopulmonary bypass.
Ohe
Y
Y
Department of Anesthesiology, Tokyo Women's Medical College Daini Hospital.
Satoh
K
K
Hashimoto
N
N
Tachibana
C
C
Fukada
T
T
Furuya
Y
Y
D001775:Blood Circulation / Q000187:drug effects* / Q000502:physiology; D002315:Cardiopulmonary Bypass; D002395:Catecholamines / Q000008:administration & dosage*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects* / Q000502:physiology
D002395:Catecholamines; D008775:Methylprednisolone