Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease.
We followed 16 patients with a variety of mitochondrial diseases over one to four periods of treatment (2 months each) with coenzyme Q10 plus vitamins K3 and C, riboflavin, thiamine, and niacin, using independent measures of oxidative metabolism to assess efficacy. There were large (> threefold) increases in serum coenzyme Q10 concentrations with treatment, but no measure of oxidative metabolism showed significant improvement with treatment for the group, nor did any individual patient show significant, reproducible, objective clinical improvement. The results suggest that coenzyme Q10 plus vitamin therapy does not significantly improve mitochondrial oxidative metabolism in patients with mitochondrial disease in general. Any clinical benefit that may follow from short-term administration appears slight.
Montreal Neurological Institute and Hospital, PQ, Canada.
P M
PM
Matthews
B
B
Ford
R J
RJ
Dandurand
D H
DH
Eidelman
D
D
O'Connor
A
A
Sherwin
G
G
Karpati
F
F
Andermann
D L
DL
Arnold
D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D003067:Coenzymes; D004272:DNA, Mitochondrial / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D007773:Lactates / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D009132:Muscles / Q000378:metabolism; D010101:Oxygen Consumption; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D005082:Physical Exertion; D017354:Point Mutation; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D003067:Coenzymes; D004272:DNA, Mitochondrial; D007773:Lactates; D010710:Phosphates; D014815:Vitamins; D010725:Phosphocreatine; D014451:Ubiquinone; D000255:Adenosine Triphosphate; C024989:coenzyme Q10