Hepatotoxicity associated with pharmacologic agents in dogs and cats.
Historical aspects, mechanisms, and treatment of hepatotoxicity associated with pharmacologic agents in dogs and cats are discussed. All agents that cause clinically relevant drug-induced hepatotoxicity have been reviewed within the last 5 years; therefore, only selected drugs that more recently have been observed to cause hepatic injury in companion animals are described in detail. These include diethylcarbamazine/oxibendazole, phenobarbital, and trimethoprim/sulfadiazine.
Department of Companion Animal and Special Species Medicine, North Carolina State University College of Veterinary Medicine, Raleigh.
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D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects; D001562:Benzimidazoles / Q000009:adverse effects; D002371:Cat Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D002415:Cats; D056486:Chemical and Drug Induced Liver Injury; D004049:Diethylcarbamazine / Q000009:adverse effects; D004283:Dog Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D004285:Dogs; D004338:Drug Combinations; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000378:metabolism / Q000628:therapy / Q000662:veterinary*; D010634:Phenobarbital / Q000009:adverse effects; D013411:Sulfadiazine / Q000009:adverse effects; D014295:Trimethoprim / Q000009:adverse effects
D000871:Anthelmintics; D001562:Benzimidazoles; D004338:Drug Combinations; C011321:oxibendazole; D013411:Sulfadiazine; D014295:Trimethoprim; D004049:Diethylcarbamazine; D010634:Phenobarbital