Teratogenic hydrazines: a review.
The review summarizes the results of 30 hydrazines, which were studied in humans and in six animal species for teratogenic activities. Of these, 23 chemicals were found to induce physical defects in the developing embryos of animals. Six hydrazines failed to induce teratogenic abnormalities in animals under the experimental conditions. Three hydrazine analogues, some of which were given in combination with other drugs to pregnant women, gave ambiguous results concerning teratogenic effects. Some of these investigations were aimed at revealing the teratogenic mode of action of hydrazines. The mechanistic aspect focused on the dose requirements of chemicals and the time period in the development of the fetus susceptible to malformation and chemoprevention. Of interest is the base compound hydrazine, which was found to be teratogenic in five animal species. In general, the hydrazines were found to be powerful teratogens, which coincided in most cases with their known carcinogenic activities.
Toth
B
B
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68198.
D000818:Animals; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000009:adverse effects / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*
D006834:Hydrazines; D013723:Teratogens