Efficacy of fenbendazole and piperazine against developing stages of toxocara and toxascaris in dogs.
In a series of controlled trials involving 59 naturally infected greyhounds, fenbendazole at a dose rate of 50 mg/kg/day for three consecutive days reduced the overall numbers of third and fourth stage Toxocara canis by 94.0 per cent and third stage, fourth stage and immature adult stages of Toxascaris leonina by 92.4 per cent. In contrast, piperazine at 100 mg/kg had little or no useful effect against the larval stages of T canis and T leonina and variable efficacy against immature adult T leonina. Fenbendazole was also 100 per cent effective against immature Trichuris vulpis. In a separate controlled experiment, puppies in three litters exposed to reinfection with T canis were treated with fenbendazole at two weeks old and again only after their mean faecal egg counts exceeded 200 epg. Between one and three doses were required to suppress the output of eggs during the puppies' first 12 weeks of life.
Department of Pathology and Infectious Diseases, Royal Veterinary College (University of London), Hertfordshire.
M A
MA
Fisher
D E
DE
Jacobs
M J
MJ
Hutchinson
E M
EM
Abbott
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000494:pharmacology* / Q000627:therapeutic use; D010270:Parasite Egg Count / Q000662:veterinary; D000077489:Piperazine; D010879:Piperazines / Q000494:pharmacology*; D017227:Toxascariasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D014114:Toxascaris / Q000187:drug effects* / Q000254:growth & development; D017166:Toxocara canis / Q000187:drug effects* / Q000254:growth & development; D014120:Toxocariasis / Q000188:drug therapy / Q000469:parasitology
D000969:Antinematodal Agents; D010879:Piperazines; D000077489:Piperazine; D005273:Fenbendazole