High casein-lactalbumin diet accelerates blood coagulation in rats.
This study investigates the influence of a high protein intake on normal hemostasis, fluid balance and organ growth. Adult rats were fed semipurified diets that contained either 18 or 56 g/100 g casein-lactalbumin for 2 wk, and the following functions were measured: food and water intake, weight gain, blood pressure, bleeding and clotting time, ADP-stimulated platelet aggregation, thrombin time, prothrombin time and partial thromboplastin time. Although food intake was depressed by the high protein diet, weight gain was not affected by the regimen. Water consumption, 24-h urine excretion and kidney weight were significantly greater in rats fed the high protein diet than in controls. High protein intake resulted in shorter barbiturate-induced sleeping time. Bleeding time and clotting time were significantly lower in rats fed the high protein diet for 7 d. However, heart rate, mean arterial pressure, plasma protein and osmolarity, platelet aggregation, prothrombin time, partial thromboplastin time and thrombin time did not differ significantly. Because a high protein intake caused rapid coagulation of blood in rats without affecting the activity of clotting factors, we suggest that this diet sensitized rats to factors that initiate clotting in vivo.
Chan
K C
KC
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Lou
P P
PP
Hargrove
J L
JL
D000818:Animals; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects*; D002364:Caseins / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D007768:Lactalbumin / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D002364:Caseins; D004044:Dietary Proteins; D007768:Lactalbumin