Increased activity of FAD-linked glycerophosphate dehydrogenase in pancreatic islets of BB rats.
In several animal models of non-insulin-dependent diabetes, a decreased activity of FAD-linked glycerophosphate dehydrogenase was recently documented in pancreatic islet, but not liver, homogenates. The present study reveals that, on the contrary, the activity of the same mitochondrial enzyme is increased in islet, but not liver or spleen, homogenates of BB, as compared to BW, rats examined before the onset of severe hyperglycemia in this animal model of autoimmune insulin-dependent diabetes.
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
J
J
Rasschaert
W J
WJ
Malaisse
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D004195:Disease Models, Animal; D005260:Female; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D051381:Rats; D013154:Spleen / Q000201:enzymology
D001786:Blood Glucose; D007328:Insulin; D002237:Carbohydrate Dehydrogenases; C056470:3-glycerophosphate dehydrogenase