Pharmacokinetic and bacteriological study of cefadroxil-salicylate and josamycin-salicylate drug regimens.
Eye, nose, throat and bronchopulmonary infections are frequently associated with inflammatory symptoms. This often leads the clinician to prescribe a combination of an anti-inflammatory and an antibiotic. Cefadroxil and josamycin are among the antibiotics most frequently used in these infections, and they are often combined with acetylsalicylic acid in various pharmaceutical formulations. The study of possible pharmacokinetic and bacteriological interactions was performed in healthy volunteers who received in a crossover protocol each of the two antibiotics, either alone or combined with acetylsalicylic acid or lysine acetylsalicylate. No marked pharmacokinetic interaction was noted except an increase in the AUC for plasma concentrations of cefadroxil when combined with a salicylate. A greater uniformity of kinetic profiles was seen with cefadroxil than with josamycin. Lastly, with the exception of one strain, the salicylates did not alter the antibacterial activity of cefadroxil.
University Hospital, Nice, France.
P
P
Dellamonica
R
R
Garraffo
H
H
Etesse-Carsenti
E
E
Bernard
V
V
Mondain
D000328:Adult; D001241:Aspirin / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002434:Cefadroxil / Q000493:pharmacokinetics* / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015570:Josamycin / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D008826:Microbial Sensitivity Tests
D002434:Cefadroxil; D015570:Josamycin; D001241:Aspirin