Penetration of ciprofloxacin into pleural fluid.
The penetration of oral 1000 mg/day ciprofloxacin into pleural fluid is investigated in 15 patients with exudative pleural effusion. After 4 days of ciprofloxacin therapy ciprofloxacin concentrations were measured in plasma and pleural exudate simultaneously by high-performance liquid chromatography (HPLC). Mean serum ciprofloxacin level was 1.58 +/- 0.91 mg/L and mean pleural exudate concentration was 1.00 +/- 0.59 mg/L. The concentrations achieved were all above the MIC90 of the majority of Gram-positive and Gram-negative pathogens. It is concluded that ciprofloxacin penetrates well into the pleural fluid.
Department of Pulmonary Disease, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
S
S
Umut
T
T
Demir
G
G
Akkan
N
N
Keskiner
V
V
Yilmaz
N
N
Yildirim
B
B
Sipahioğlu
A
A
Hasan
A
A
Barlas
K
K
Sözer
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000188:drug therapy / Q000378:metabolism*
D002939:Ciprofloxacin