Gene therapy.
Gene therapy replaces or supplements the activity of a resident defective or missing gene by a cloned functional one. A functional gene may be delivered to the target tissues ex vivo or in vivo using various physical methods and several chemical and biological vehicles. In this article we present an overview of different experimental models and the progress made in clinical studies on gene therapy and discuss the prospects of the antisense approach and the ethical concerns related to the technique.
All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
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Kumar
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Kumar
D015316:Genetic Therapy; D006801:Humans