Demonstration of the myocardial salvage effect of lithospermic acid B isolated from the aqueous extract of Salvia miltiorrhiza.
Lithospermic acid B has been isolated to > 95% purity by high performance liquid chromatography from the aqueous extract of the roots of Salvia miltiorrhiza. When infused at 5.5 mumoles/kg into the post-ischemic rabbit heart, it reduced by 62 +/- 10% (n = 8) the myocardial damage found in the saline control in a rabbit ischemia-reperfusion model.
Department of Clinical Biochemistry, University of Toronto, Ont., Canada.
K P
KP
Fung
L H
LH
Zeng
J
J
Wu
H N
HN
Wong
C M
CM
Lee
P M
PM
Hon
H M
HM
Chang
T W
TW
Wu
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D008854:Microscopy, Electron; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits
D004365:Drugs, Chinese Herbal; C061091:lithospermate B