Pigmented pheochromocytomas of the adrenal medulla.
Three primary pigmented pheochromocytomas of the adrenal gland are presented. The pigment in all cases proved to be melanin. Two of the pheochromocytomas were sporadic and histologically typical, except for a focal spindle cell configuration in one. It is believed that the morphologic appearance of these tumors represents divergent differentiation from neural crest, expressing typical pheochromocytoma (polygonal cells) and melanocytic features (melanin pigment).
Department of Anatomical Pathology, Royal Melbourne Hospital, Australia.
R
R
Chetty
S P
SP
Clark
D A
DA
Taylor
D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D000313:Adrenal Medulla; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008543:Melanins / Q000378:metabolism*; D008854:Microscopy, Electron; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism* / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism
D008543:Melanins; D009418:S100 Proteins