Adsorption of mexiletine onto activated charcoal in macrogol-electrolyte solution.
Adsorption studies in vitro of mexiletine onto activated charcoal were performed in macrogol (polyethylene glycol)-electrolyte solution (PEG-ELS) and JP XII disintegration medium No. 2 (second medium). Mexiletine was adsorbed more extensively onto activated charcoal in PEG-ELS than that in JP XII second medium. The maximum adsorptive capacity of activated charcoal for the drug was 328 and 284 mg per gram of charcoal in PEG-ELS and JP XII second medium, respectively. In addition, the equilibrium constant of activated charcoal estimated according to the Langmuir equation was 0.079 and 0.034 l per gram of charcoal in PEG-ELS and JP XII second medium, respectively. Adsorption of mexiletine onto activated charcoal was decreased by omitting macrogol, sodium sulfate or sodium bicarbonate from a standard PEG-ELS formulation. Oral activated charcoal will be useful in combination with whole bowel irrigation with PEG-ELS in mexiletine overdose because of its excellent adsorbability in the solution.
Department of Pharmacy, Kumamoto University Hospital, Japan.
K
K
Arimori
M
M
Deshimaru
E
E
Furukawa
M
M
Nakano
D000327:Adsorption; D002606:Charcoal / Q000737:chemistry*; D062787:Drug Overdose / Q000628:therapy; D004573:Electrolytes / Q000737:chemistry*; D006801:Humans; D008801:Mexiletine / Q000737:chemistry* / Q000506:poisoning; D011092:Polyethylene Glycols / Q000737:chemistry*; D007507:Therapeutic Irrigation
D004573:Electrolytes; D002606:Charcoal; D008801:Mexiletine; D011092:Polyethylene Glycols