Morphological aspects of the hormone-induced pathomorphosis of endometrial carcinoma.
The paper presents the results of treatment of 488 patients with primary endometrial carcinoma. All patients received adjuvant hormonotherapy (oxyprogesterone caproate, and some patients previously oestrogens) in combination with surgery and postoperative irradiation. The study of tumor morphology on ultrastructural level and by histochemical methods provided additionally useful findings. Depending on the degree of changes in the tumor structure after hormone therapy it appeared possible to distinguish the following varieties of results: 1) Complete regression of tumor. 2) An increase in structural and functional differentiation as compared with the initial level differentiation of tumor. 3) Absence or doubtful effect. In the paper the working classification of malignant adrenogenic tumors of the uterus is presented.
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Chepick
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D017024:Chemotherapy, Adjuvant; D002996:Clomiphene / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D004798:Enzymes / Q000096:biosynthesis; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006003:Glycogen / Q000096:biosynthesis; D006801:Humans; D006908:Hydroxyprogesterones / Q000494:pharmacology / Q000627:therapeutic use*; D008854:Microscopy, Electron; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012074:Remission Induction
D000970:Antineoplastic Agents; D003278:Contraceptives, Oral, Hormonal; D004798:Enzymes; D006908:Hydroxyprogesterones; D002996:Clomiphene; C074283:estradiol 3-benzoate; D000077713:17 alpha-Hydroxyprogesterone Caproate; D004958:Estradiol; D006003:Glycogen