Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro.
The addition of ingestable particles (opsonized erythrocytes or latex beads) or a phorbol ester activates monocytes--derived human macrophages (MDHM) cultured in vitro, and markedly reduces virion release from HIV-infected MDHM as well as their ability to transmit the infection to cocultured lymphoid CD4-positive CEM cells.
Institute of General Pathology, University of Parma, Italy.
G
G
Piedimonte
M
M
Montroni
G
G
Silvestri
L
L
Silvotti
A
A
Donatini
L
L
Rossi
A F
AF
Borghetti
M
M
Magnani
D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008262:Macrophage Activation / Q000502:physiology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D009000:Monocytes / Q000276:immunology / Q000382:microbiology*; D010587:Phagocytosis / Q000502:physiology*; D014779:Virus Replication / Q000276:immunology*