Bulge-activation hypothesis: is it valid?
This essay is a critique of a revolutionary hypothesis, and of the language used to frame it, that offers a novel interpretation for the dynamics of the follicular cycle by distinguishing, distinctly, germinative cells in the bulge from matrical cells in the bulb. Curiously, this intriguing "bulge-activation hypothesis" elicited practically no response in the scientific literature, and our critique is designed to rectify that.
Dermatopathology Unit, New York University Medical Center, New York 10016.
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Holecek
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Ackerman
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology / Q000503:physiopathology; D005350:Fibroma / Q000473:pathology / Q000503:physiopathology; D006197:Hair / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology; D008648:Mesoderm / Q000166:cytology; D012038:Regeneration / Q000502:physiology; D012867:Skin / Q000166:cytology; D012878:Skin Neoplasms / Q000473:pathology / Q000503:physiopathology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology