Kinetics of trichloroethylene elimination from venous blood after acute inhalation poisoning.
The kinetics of trichloroethylene were examined in three men, 28-36 years old, hospitalized after an acute occupational exposure. The trichloroethylene concentration of venous blood was determined by gas chromatography with headspace analysis; urinary trichloroacetic acid was assayed by the colorimetric method of Fujiwara. The kinetics of blood trichlorethylene (t1/2 21.7 h) and the urinary elimination of trichloracetic acid over six days were used to calculate the total inhalation exposures. Blood trichlorethylene was diagnostically more relevant than urinary trichloracetic acid.
Kostrzewski
P
P
Department of Toxic Substances Metabolism, Institute of Occupational Medicine, Lódź, Poland.
Jakubowski
M
M
Kołaciński
Z
Z
D000280:Administration, Inhalation; D000328:Adult; D002849:Chromatography, Gas; D006207:Half-Life; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D014238:Trichloroacetic Acid / Q000652:urine; D014241:Trichloroethylene / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*
D014241:Trichloroethylene; D014238:Trichloroacetic Acid