Prognostic value of the CD4/CD8 lymphocyte ratio in moderately burned patients.
We investigated CD3+, CD4+ and CD8+ T-cell subpopulations, as well as the CD4/CD8 ratio in 84 moderately burned patients with injuries affecting 11-36 per cent of their total body surface area (TBSA). These lymphocyte subpopulations were quantified by indirect immunofluorescence measurement 7 and 60 days postburn. The results obtained 7 days postburn were highly significant in those patients who developed septicaemia, all of whom had considerably decreased CD4+ and increased CD8+ T-cell numbers, as well as inverted CD4/CD8 ratios. Consequently, the CD4/CD8 ratio may provide valuable information for prognosis of patient evolution and the establishment of early treatment in order to avoid likely future complications.
Servicio de Cirugía Plástica y Quemados, Hospital Reina Sofía, Córdoba, Spain.
L F
LF
Rioja
P
P
Alonso
J
J
de Haro
J
J
de la Cruz
D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000150:complications* / Q000276:immunology / Q000473:pathology; D017252:CD3 Complex / Q000032:analysis; D016516:CD4-CD8 Ratio; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018805:Sepsis / Q000150:complications / Q000276:immunology
D017252:CD3 Complex