[Study of the interaction of alpha-tocopherol with phospholipids, fatty acids, and their oxygenated derivatives by (31)P-NMR spectroscopy].
Interaction of alpha-tocopherol with phospholipids, oleic, ricinoleic acids and linoleic acid hydroperoxides was investigated by means of 31P NMR spectroscopy on a model artificial membranes containing egg phosphatidylcholine and lysophosphatidylcholine. alpha-Tocopherol was shown to support the bilayer organization of lysophospholipids, whereas its introduction into the lecithin-water system stimulated the hexagonal phase formation. Free fatty acids exhibited a synergism to alpha-tocopherol, the effect of the hexagonal phase formation being at most increased by oxygenated acids--ricinoleic acid and linoleic acid hydroperoxides. In accordance with the experimental data, a conclusion about modifying and structuring action of alpha-tocopherol was made. Origin of the alpha-tocopherol's modulating effect on the membrane structure and a possible role of hexagonal phase forming upon its action in the course of peroxidation of lipids was discussed.
Chudinova
V V
VV
Zakharova
E I
EI
Alekseev
S M
SM
Chupin
V V
VV
Evstigneeva
R P
RP
D005227:Fatty Acids / Q000737:chemistry*; D008051:Lipid Bilayers; D008244:Lysophosphatidylcholines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D010100:Oxygen / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry*; D010759:Phosphorus Isotopes; D014810:Vitamin E / Q000737:chemistry*
D005227:Fatty Acids; D008051:Lipid Bilayers; D008244:Lysophosphatidylcholines; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010759:Phosphorus Isotopes; D014810:Vitamin E; D010100:Oxygen
Izuchenie vzaimodeĭstviia alpha-tokoferola s fosfolipidami, zhirnymi kislotami i ikh oksigenirovannymi proizvodnymi metodom (31)P-IaMR- spektroskopii.