Hemorrhagic diathesis associated with a hereditary platelet disorder in Simmental cattle.
A severe bleeding disorder in Simmental cattle has been described in widespread locations in the USA and Canada. The clinical findings are consistent with a hemophilia-like disease or, more precisely, a hereditary hemorrhagic diathesis and include spontaneous epistaxis, hematuria, and excessive bleeding associated with trauma or standard management procedures such as tattooing, ear tagging, and castration. A preliminary investigation of this defect showed that blood-platelet numbers and coagulation profiles of affected cattle were normal. Affected animals have a marked dysfunction of platelets (thrombopathy), termed Simmental hereditary thrombopathy. The defect is very similar or identical to that described in the same breed by 2 other laboratories.
Steficek
B A
BA
Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
Thomas
J S
JS
Baker
J C
JC
Bell
T G
TG
D000818:Animals; D001791:Blood Platelet Disorders / Q000097:blood / Q000235:genetics / Q000662:veterinary*; D001792:Blood Platelets / Q000473:pathology / Q000648:ultrastructure; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000235:genetics; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology; D010979:Platelet Function Tests / Q000662:veterinary