Neuroendocrine and cardiovascular effects of MDE in healthy volunteers.
The drug 3,4-methylenedioxyethamphetamine ([MDE] also known as "Eve") is a less toxic analog of 3,4-methylenedioxymethamphetamine (also known as "Ecstasy") with similar psychotropic effects in humans. In a double-blind placebo-controlled, cross-over study we administered 140 mg of MDE or placebo orally to eight healthy male volunteers at 1:30 P.M. Serum cortisol, prolactin (PRL), and growth hormone (GH) levels, as well as blood pressure, and heart rate were measured every 20 minutes until 5:00 P.M. Administration of MDE was followed by statistically significant long-lasting increases of serum cortisol, PRL, systolic blood pressure, and heart rate, and by a trend toward blunting of GH secretion. The neuroendocrine and cardiovascular effects of MDE are comparable to those of other phenethylamines with the exception of the effect on GH secretion.
Gouzoulis
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E
Department of Psychiatry, University of Freiburg, Federal Republic of Germany.
von Bardeleben
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U
Rupp
A
A
Kovar
K A
KA
Hermle
L
L
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D015198:Designer Drugs / Q000493:pharmacokinetics / Q000494:pharmacology*; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography
D015198:Designer Drugs; D006728:Hormones; D015104:3,4-Methylenedioxyamphetamine; C051800:3,4-methylenedioxyethamphetamine