Fine needle aspiration (FNA)-induced necrosis of tumours of the thyroid.
Two cases of necrosis of thyroid oxyphilic tumours following FNA are reported. The first patient received surgery 4 weeks after FNA and histological examination revealed an encapsulated and totally necrotic tumour 2 cm in diameter. In the second patient surgery was performed after 25 days. Histological examination showed a 0.7 cm diameter tumour consisting mainly of fibrous tissue with residual oxyphilic tumour cells only in a small peripheral rim. In both patients no capsular or vascular invasion and no blood vessel thrombosis were present. A review of the literature revealed that oxyphilic tumours are susceptible to post-FNA necrosis, which might be due to the compromised vascular supply after FNA in conjunction with the intrinsic energy deficiency of oncocytic tumour cells.
Ramp
U
U
Institute of Pathology, University Hospital, Düsseldorf, Germany.
Pfitzer
P
P
Gabbert
H E
HE
D018249:Adenoma, Oxyphilic / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001707:Biopsy, Needle / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery