[Amniocentesis to study the fetal karyotype before 16 weeks of amenorrhea. Prospective study comparing it with conventional amniocentesis].
In a prospective study, we compared early amniocentesis (13-15 weeks of amenorrhea, n = 67) with conventional amniocentesis (16-20 weeks, n = 105). Early amniocentesis was not associated with complications and cell culture was possible in every case. Sampling failures were more frequent (4.5% vs 0.9%, p = 0.057), but had no deleterious effects and this rate can probably be reduced with experience. The mean time required for karyotyping was only slightly longer: 17.0 (SD 2.8) days vs 15.8 (SD 2.0) days (p < 0.01). These results agree with other recent studies suggesting that early amniocentesis is a simple and safe method which can be performed several weeks before conventional amniocentesis.
Gabriel
R
R
Département de Gynécologie-Obstétrique, CHRU, Hôpital Maison-Blanche, Reims.
Harika
G
G
Carré-Pigeon
F
F
Quéreux
C
C
Wahl
P
P
D000328:Adult; D000649:Amniocentesis / Q000379:methods* / Q000592:standards; D005069:Evaluation Studies as Topic; D005260:Female; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal
L'amniocentèse pour étude du caryotype foetal avant 16 semaines d'aménorrhée. Etude prospective et comparative avec l'amniocentèse conventionnelle.