Genetics and obstructive sleep apnea syndrome: a study of human leukocyte antigen (HLA) typing.
To investigate the possible influence of genetics in subjects with obstructive sleep apnea syndrome (OSAS), HLA-A, B, C, and DR antigens were studied in 32 Japanese subjects with OSAS. The frequency of HLA-A2 antigen was markedly increased in the patients with OSAS compared with normal controls (81.3% vs 40.6%) and compared with the Japanese population (40.7%), Pc < 0.035 and Pc < 0.007, respectively. HLA-B39 was found more frequently in OSAS patients than in the Japanese population (Pc < 0.018), but not in the controls. No significant deviation was observed in the frequencies of HLA-C and DR antigens between the OSAS patients and the controls. We conclude that genetics is important in the development of OSAS.
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
T
T
Yoshizawa
T
T
Akashiba
K
K
Kurashina
K
K
Otsuka
T
T
Horie
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012891:Sleep Apnea Syndromes / Q000235:genetics* / Q000276:immunology*
D006680:HLA Antigens; D006684:HLA-DR Antigens