Clinical relevance of serum amyloid A protein monitoring in urinary tract infections.
We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), alpha-1-antichymotrypsin (ACT) and alpha-1-acid glycoprotein (AGP) were determined daily in sera from 18 treated patients. Two patterns of response could be identified: responders and non-responders whose therapy had to be changed. Mean values for each acute phase protein were calculated daily in both responders and non-responders. Statistical evaluation of the significance between the means for each protein was also performed on a daily basis and showed P < 0.01 for SAA and CRP on day 3, for ACT on day 5, and for AGP on day 6. SAA and CRP appear to be the most reliable markers for antimicrobial therapy monitoring in patients with urinary tract infections.
Department of Biochemistry and Biomedicine, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.
M T
MT
Casl
M
M
Sabljar-Matovinović
S
S
Kovacević
D
D
Pocanić
V
V
Preden-Kereković
N
N
Jagarinec
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D000685:Serum Amyloid A Protein / Q000032:analysis*; D014552:Urinary Tract Infections / Q000097:blood* / Q000188:drug therapy; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
D000900:Anti-Bacterial Agents; D009961:Orosomucoid; D000685:Serum Amyloid A Protein; D000514:alpha 1-Antichymotrypsin; D002097:C-Reactive Protein