Effect of acetyl-L-carnitine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is believed to induce neurotoxicity by inhibiting mitochondrial oxidative metabolism, whereas acetyl-L-carnitine (ALC) facilitates this process by transporting fatty acids into mitochondria for beta oxidation. We investigated whether large doses of ALC given by gavage for 1 week before and 1 week after MPTP could ameliorate MPTP neurotoxicity in mice. We found that ALC had no effect on MPTP-induced depletion of striatal dopamine and its metabolites.
Harik
S I
SI
Department of Neurology, University Hospitals of Cleveland, OH.
Hritz
M A
MA
D000108:Acetylcarnitine / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000108:Acetylcarnitine; D004298:Dopamine