HMG CoA reductase inhibitors for treatment of hyperlipidemia.
Lowering serum cholesterol levels in patients with hyperlipidemia has been shown to decrease deaths due to coronary heart disease. While diet is the mainstay of treatment for hyperlipidemia, drug therapy is necessary to achieve treatment goals in certain patients. The HMG CoA reductase inhibitors are the most effective cholesterol-lowering agents currently available. These agents are well tolerated and have few serious side effects. Their major disadvantage is their high cost.
Texas Tech University Health Sciences Center, Lubbock.
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Kantner
D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D016527:Drug Costs; D004347:Drug Interactions; D016903:Drug Monitoring; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D016896:Treatment Outcome
D004041:Dietary Fats; D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol