Search for an antidote to electroconvulsion and lethality in aminophylline-sensitized mice.
Diazepam (10 mg/kg i.p.) or MK-801 (0.25 mg/kg i.p.) offered complete protection against corneal electroshock (30 mA x 0.2 s)-induced tonic seizures and lethality but failed to protect from aminophylline (150 mg/kg i.p.) + electroshock (15 mA x 0.2 s)-induced tonic seizures and lethality in mice. The diazepam (2.5 mg/kg i.p.) and MK-801 (0.25 mg/kg i.p.) combination completely protected the mice from aminophylline + electroshock-induced seizures and lethality. Sodium valproate (500 mg/kg i.p.) protected the mice from electroshock (30 mA) per se and aminophylline + electroshock (15 mA)-induced seizure and lethality. The present study established the neurosensitizing potential of a single, non-convulsive dose of aminophylline for electroconvulsion due to subthreshold intensity electroshock and demonstrated the prophylactic efficacy of sodium valproate and the synergistic therapeutic potential of diazepam and MK-801 combination against such seizure attacks.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
A
A
Chakrabarti
Y
Y
Chugh
P L
PL
Sharma
D000628:Aminophylline / Q000633:toxicity*; D000818:Animals; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000627:therapeutic use*; D004597:Electroshock; D008297:Male; D051379:Mice; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
D000628:Aminophylline; D014635:Valproic Acid; D016291:Dizocilpine Maleate; D003975:Diazepam