Umbilical and placental vessels: modifications of their mechanical properties in preeclampsia.
OBJECTIVE
Our objective in this study was to assess the basic mechanical properties of umbilical and chorionic vessels of placentas delivered after both normal and preeclamptic pregnancies.


METHODS
Placentas were selected when the parturient women were admitted to the delivery room. Normal pregnancy (n = 17) was characterized by delivery at term (38 to 40 weeks) after uncomplicated pregnancy without any medication. Preeclamptic pregnancy (n = 7) was characterized by delivery after 28 weeks of pregnancy (28 to 39 weeks) after sustained hypertension and proteinuria. Arteries and veins from the umbilical cord and chorionic plate were prepared in rings for in vitro study in tissue baths. Passive and active (on stimulation by potassium chloride or serotonin) mechanical properties of these vessels were studied.


RESULTS
In vessels from normal pregnancy, responsiveness, but not sensitivity, was increased with increasing passive tension on vessels until optimal tension was reached. The passive stretch-tension curve was shifted downward in umbilical veins and upward in umbilical arteries and chorionic veins obtained from preeclamptic mothers in comparison with normal parturient women. In the absence of passive tension, contractions in response to potassium chloride were produced in all umbilical veins and some chorionic veins from preeclampsia but not from normal pregnancy. Developed wall tension curves in chorionic vessels from preeclampsia were shifted upward. In umbilical veins and arteries and in chorionic veins, the optimal passive tension was lower in tissues from preeclampsia than in tissues from normal pregnancy.


CONCLUSIONS
Our results indicate that both passive and active mechanical properties of umbilical vessels are modified after pregnancy complicated by preeclampsia.
Laboratoire de Pharmacologie Vasculaire et Périnatale, Centre de Recherche, Hôpital Ste-Justine, Canada.
C
C
Bertrand
L
L
Duperron
J
J
St-Louis
D001158:Arteries / Q000503:physiopathology; D002824:Chorionic Villi / Q000098:blood supply*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012701:Serotonin / Q000494:pharmacology; D014470:Umbilical Cord / Q000098:blood supply*; D014680:Veins / Q000503:physiopathology
D012701:Serotonin; D011189:Potassium Chloride