Synthesis and mitogenic activity of nonreducing-sugar subunit analogs of bacterial lipid A composed only of 3-hydroxytetradecanoic acid and its homologs.
Novel analogs of the nonreducing-sugar subunit of bacterial lipid A, which were composed only of 3-hydroxytetradecanoic acid and its homologs, were synthesized. These analogs exhibited significant mitogenic activity.
Ishida
H
H
Department of Applied Bioorganic Chemistry, Gifu University, Japan.
Fujishima
Y
Y
Ogawa
Y
Y
Kumazawa
Y
Y
Kiso
M
M
Hasegawa
A
A
D001419:Bacteria / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry; D008050:Lipid A / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
D005227:Fatty Acids; D008050:Lipid A; D008934:Mitogens; C056260:GLA 60