TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity.
Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus. It showed excellent protective effects against an experimental methicillin-resistant S. aureus infection in mice.
Discovery Research Laboratories II, Takeda Chemical Industries, Ltd., Osaka, Japan.
N
N
Katayama
S
S
Fukusumi
Y
Y
Funabashi
T
T
Iwahi
H
H
Ono
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003589:Cytophaga / Q000737:chemistry*; D004151:Dipeptides / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D007928:Lethal Dose 50; D016106:Methicillin Resistance; D051379:Mice; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D004151:Dipeptides; C081415:TAN 1057A; C081416:TAN 1057B; C081417:TAN 1057C; C081418:TAN 1057D