[Morphology and function of intra-hepatic lymphocytes derived mast cells].
We have examined the functional characteristics of mast cells grown in tissue culture from intra-hepatic lymphocytes of mice (IHL-MC) and compared them with mast cells grown from bone marrow (BMC-MC). Intrahepatic lymphocyte derived mast cells had the functional characteristics of cultured mast cells. These cells were stained by alcian blue, had a lower histamine content than rat peritoneal mast cells (considered to be a model of connective tissue type mast cells) and responded to Ca2+ ionophore and IgE receptor mediated stimulation. However, there were some differences between IHL-MC and BMC-MC. IHL-MC had a higher histamine content and lower growth activity by T-cell derived factor than BMC-MC.
Department of Microbiology and Immunology, Nippon Medical School.
Y
Y
Nakagawa
E
E
Watari
K
K
Yokomuro
D000818:Animals; D001854:Bone Marrow Cells; D002469:Cell Separation; D002478:Cells, Cultured; D005260:Female; D008099:Liver / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D008407:Mast Cells / Q000166:cytology* / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H