Fluorescence in situ hybridization and cytogenetics of hemopoietic malignancies: new developments.
Fluorescence in situ hybridization (FISH) is currently developed to analyse chromosomal abnormalities of hemopoietic malignancies in several ways: description of chromosomal rearrangements using specific probes or chromosome painting; delineation of chromosomal breakpoints with probes previously localized to chromosomal bands; hybridization to interphase nuclei to detect numerical changes and, now, some structural abnormalities. Examples of usefulness of FISH to study hemopoietic malignancies are given.
Unité INSERM U, CNRS, Institut de Génétique Moléculaire, Paris, France.
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D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic