[Resistance to anticoagulant activity of heparin in a patient for cardiac surgery].
Resistance to anticoagulant activity of heparin was observed in a patient for cardiac surgery. The activated coagulation time (ACT) was maintained over 300 seconds with additional doses of heparin which mounted to the total of 29 ml in 3 hours during cardiopulmonary bypass. Although antithrombin-III activity was not measured in this case, the heparin resistance might have been caused by the decrease in the activity of antithrombin-III which might have resulted from the preoperative malnutrition, infection of urinary tract and/or institution of intraaortic balloon pumping (IABP).
Department of Anesthesiology, School of Medicine, Kitasato University, Sagamihara.
F
F
Asato
M
M
Arai
F
F
Goto
Y
Y
Nishikawa
D006348:Cardiac Surgical Procedures; D004351:Drug Resistance; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006493:Heparin