[The capacity of rat clonogenic precursor cells of the hemopoietic stroma (CFU-F) to recover from radiation damages].
The ability of cell precursors of the haemopoietic stroma (CFU-F), that are present in the bone marrow of adult rats, to recover from potentially lethal and sublethal radiation damages has been investigated. The highest reparability, with respect to potentially lethal damages, is displayed by the most radioresistant CFU-F population, that forms loose colonies (clones) in a culture; the slope of the dose-response curve, not the extrapolation number, changes, and heterogeneity of the CFU-F population is observed. The results obtained confirm the presence of heterogeneity in the population of CFU-F, that was revealed in studying their radiosensitivity by the formation of dense and loose fibroblast colonies in a culture.
Kolesnikova
A I
AI
Konopliannikov
A G
AG
Kal'sina
S Sh
SSh
Lepekhina
L A
LA
Zaĭtsev
A V
AV
Waĭnson
A A
AA
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002470:Cell Survival / Q000528:radiation effects; D002999:Clone Cells / Q000166:cytology / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
Sposobnost' krysinykh klonogennykh kletok-predshestvennikov gemopoéticheskoĭ stromy (KOE-F) k vosstanovleniiu ot radiatsionnykh povrezhdeniĭ.