In vitro activities of ramoplanin, selected glycopeptides, fluoroquinolones, and other antibiotics against clinical bloodstream isolates of gram-positive cocci.
The susceptibilities of 316 gram-positive bacteremic isolates to ramoplanin, vancomycin, and teicoplanin and seven other antibiotics were tested. Ramoplanin demonstrated MICs of < or = 0.25 microgram/ml for at least 99% of Staphylococcus aureus isolates and 100% of coagulase-negative staphylococci tested. For both oxacillin-susceptible and oxacillin-resistant S. aureus and coagulase-negative staphylococci, the activity of ramoplanin surpassed those of both vancomycin and teicoplanin. Ramoplanin and teicoplanin had comparable activities against enterococci and Streptococcus pneumoniae and were superior to vancomycin.
Lawrence
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T
Department of Medical Technology, School of Medicine, State University of New York, Buffalo 14214.
Rotstein
C
C
Beam
T R
TR
Gorzynski
E A
EA
Amsterdam
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D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D047630:Depsipeptides; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000382:microbiology*; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010456:Peptides, Cyclic; D017334:Teicoplanin / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D047630:Depsipeptides; D024841:Fluoroquinolones; D010456:Peptides, Cyclic; C041438:ramoplanin; D017334:Teicoplanin; D014640:Vancomycin; D010068:Oxacillin