High-dose adrenaline in adult in-hospital asystolic cardiopulmonary resuscitation: a double-blind randomised trial.
Forty intensive care unit patients requiring cardiopulmonary resuscitation were randomised to receive either the standard dose of adrenaline (1 mg every five minutes) or high-dose adrenaline (10 mg every five minutes). In the majority of patients, overwhelming sepsis was the major contributing factor leading to cardiac arrest. In this group of patients no difference could be detected in response to high-dose adrenaline compared with the standard dose. Although no side-effects were noted with this high dose of adrenaline, more investigation is required prior to its routine use in cardiopulmonary resuscitation.
Department of Anaesthesia, University of the Witwatersrand, Johannesburg, South Africa.
J
J
Lipman
W
W
Wilson
S
S
Kobilski
J
J
Scribante
C
C
Lee
P
P
Kraus
J
J
Cooper
J
J
Barr
D
D
Moyes
D000328:Adult; D001424:Bacterial Infections; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D003422:Critical Care; D004311:Double-Blind Method; D004562:Electrocardiography; D004837:Epinephrine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D015996:Survival Rate
D004837:Epinephrine