Autoantibodies in systemic lupus erythematosus.
Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are addressing the following questions: How is tolerance lost? What accounts for the selection of the antigens? What perpetuates the autoimmune response in SLE?
Hospital for Special Surgery-Cornell University Medical Center, New York, New York, USA.
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D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D000939:Epitopes; D006801:Humans; D007108:Immune Tolerance; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D000941:Antigens; D001323:Autoantibodies; D000939:Epitopes