Bulk magnetic susceptibility induced broadening in the 19F NMR of suspended leukemic cells.
The relevance of bulk magnetic susceptibility (BMS) induced broadening to in vivo NMR studies of intact cells has been examined and the significance of the contribution of BMS difference to the resolution of intra- and extracellular resonances was demonstrated. BMS difference between intra- and extracellular compartments was found to limit the resolution of intra- and extracellular 19F resonances of fluoro compounds in leukemic cells.
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
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D000081:Acetamides; D005110:Extracellular Space / Q000737:chemistry / Q000378:metabolism; D005461:Fluorine / Q000032:analysis*; D005463:Fluoroacetates; D006801:Humans; D007424:Intracellular Fluid / Q000737:chemistry / Q000378:metabolism; D007938:Leukemia / Q000378:metabolism / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008280:Magnetics; D008674:Metals, Rare Earth / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000032:analysis / Q000493:pharmacokinetics; D014407:Tumor Cells, Cultured
D000081:Acetamides; D005463:Fluoroacetates; D008674:Metals, Rare Earth; D005461:Fluorine; C030688:trifluoroacetamide; D014269:Trifluoroacetic Acid