Stress-induced hypertension in the borderline hypertensive rat: stimulus duration.
Blood pressure and circulating catecholamines were evaluated in borderline hypertensive rats (BHR) that were exposed to daily sessions of either short (20 min) or long (120 min) duration air-jet stimulation. Indirect measures of systolic blood pressure indicated that within 2 weeks both experimental groups developed stress-induced hypertension in comparison to home cage controls. Animals exposed to 120 min stress sessions had significantly higher systolic blood pressure relative to the 20 min group. However, direct measures of blood pressure taken after 5 weeks of daily stress did not reveal any differences between the stress groups. Daily measurements indicated that acute changes in blood pressure during stress were modest and transient, suggesting little contribution to the chronic elevation in blood pressure observed as a consequence of stress. Circulating catecholamines were significantly increased by the stressor. Epinephrine returned to baseline within 60 min, although norepinephrine remained elevated throughout the 120 min session. The results indicate that increasing the duration of daily air jet stimulation did not impact the development of stress-induced hypertension over the 5-week measurement period.
Hatton
D C
DC
Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098.
DeMerritt
J
J
Coste
S C
SC
McCarron
D A
DA
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D004837:Epinephrine / Q000097:blood; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D013997:Time Factors
D009638:Norepinephrine; D004837:Epinephrine