4-Aminopyridine in patients with multiple sclerosis: dosage and serum level related to efficacy and safety.
In a recent randomized, double-blind, placebo-controlled crossover trial, we demonstrated efficacy of 4-aminopyridine (4-AP) in improving disability of patients with multiple sclerosis (MS). Here we describe the relationship between dosage, serum level, efficacy, and safety of intravenously and orally administered 4-AP in the same group of 70 MS patients. After both intravenous and oral administration there was a significant relationship between serum levels and 4-AP doses used (p < 0.001 and p < 0.01, respectively). The use of 4-AP in oral doses three times a day showed a large variation and fluctuation in serum levels. After 12 weeks of oral treatment (maximum daily dosage 0.5 mg/kg body weight), a statistically significant improvement was found for the smooth pursuit gain of the eye movements (estimated effect 0.14, 95% confidence interval 0.06-0.23, p < 0.001). The amount of improvement was significantly related to 4-AP serum levels (p = 0.0013). Side effects after intravenous 4-AP occurred frequently and were very troublesome (pain in infusion arm, dizziness). Side effects during oral treatment (dizziness, paresthesias) were very mild and occurred 30-45 min after intake of the medication and could be related to high serum levels.
Van Diemen
H A
HA
Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
Polman
C H
CH
Koetsier
J C
JC
Van Loenen
A C
AC
Nauta
J J
JJ
Bertelsmann
F W
FW
D015761:4-Aminopyridine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011698:Pursuit, Smooth / Q000187:drug effects
D015761:4-Aminopyridine