Human interferon alpha fails to inhibit the development of Babesia bigemina and Anaplasma marginale infections in cattle.
Studies were undertaken to determine whether human interferon alpha (HuIFN-alpha) administered orally could inhibit the development of clinical disease caused by the intraerythrocytic protozoan Babesia bigemina and the intraerythrocytic rickettsia Anaplasma marginale in cattle. HuIFN-alpha did not inhibit intraerythrocytic multiplication of either of the two parasites, suggesting that there is no role for HuIFN-alpha administered orally in the control of these pathogens.
Orinda
G O
GO
CSIRO Division of Tropical Animal Production, Indooroopilly, Qld., Australia.
Wright
I G
IG
Leatch
G
G
Young
A S
AS
D000712:Anaplasmosis / Q000517:prevention & control*; D000818:Animals; D001404:Babesiosis / Q000517:prevention & control*; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology / Q000517:prevention & control*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*
D016898:Interferon-alpha