A study of wound healing in the E11.5 mouse embryo by light and electron microscopy.
In this paper we report our light and electron microscopic studies of the healing of a simple excisional lesion to the E11.5 mouse embryo hindlimb. The wounded living embryo is cultured in a roller bottle and under such conditions the lesion is completely re-covered with epithelium by 24 hr. We discuss how our studies of such a simple wound healing model may offer insight into the mechanisms of tissue repair generally.
Department of Human Anatomy, Oxford University, UK.
J
J
McCluskey
J
J
Hopkinson-Woolley
B
B
Luke
P
P
Martin
D000818:Animals; D016923:Cell Death / Q000502:physiology; D046508:Culture Techniques; D004817:Epidermis / Q000196:embryology; D006614:Hindlimb / Q000196:embryology*; D051379:Mice; D008853:Microscopy; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D014945:Wound Healing / Q000502:physiology*