Kinetics of drug transfer to the fetus.
Experimental studies in animal models have contributed significantly to our understanding of the pharmacokinetics of drug disposition in the maternal-fetal unit. This chapter has considered some of the factors that are important in determining the extent of fetal exposure to drugs that are consumed by the mother during pregnancy. A knowledge of the maternal-fetal pharmacokinetics of the drugs of abuse will help provide a better understanding of the limitations of the current methods used in perinatal drug screening and in the interpretation of the results.
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
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Szeto
D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D002188:Cannabis; D003042:Cocaine / Q000493:pharmacokinetics*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006197:Hair / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D008470:Meconium / Q000378:metabolism; D009294:Narcotics / Q000493:pharmacokinetics*; D011247:Pregnancy
D009294:Narcotics; D003042:Cocaine