The use of clostridium botulinum toxin in palatal myoclonus. A preliminary report.
Palatal myoclonus is a rare syndrome characterized by involuntary rhythmical movements of the soft palate giving rise to clicking objective tinnitus. The intrusive nature of the tinnitus prompts patients to seek medical advice but to date no single treatment modality has been shown to be consistently effective. We present three cases in whom various management regimens were unsuccessful and in whom botulinum toxin injection to the palatal muscles was undertaken. All three cases were rendered free of their tinnitus with complete abolition of the myoclonus. The questions of optimum dosage as well as frequency of injection will be answered as greater numbers are treated by this method.
National Hospital for Neurology and Neurosurgery, London.
S R
SR
Saeed
G B
GB
Brookes
D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000150:complications / Q000188:drug therapy*; D010156:Palatal Muscles; D014012:Tinnitus / Q000209:etiology
D001905:Botulinum Toxins