Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. II. Physico-chemical properties and structure.
Leptolstatin, a product from Streptomyces sp. SAM1595, is a gap phase-specific inhibitor of the mammalian cell cycle. Physico-chemical properties and spectrometric analyses showed that the structure of leptolstatin is (2Z,6E,8Z,12E,14E,22E)-19,24-dihydro xy-8,10,14,16,18,20,22-heptamethyl-17-oxo-2 , 6,8,12,14,22-tetracosahexaen-5-olide.
Abe
K
K
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan.
Yoshida
M
M
Naoki
H
H
Horinouchi
S
S
Beppu
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D011090:Polyenes / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D011090:Polyenes; C081738:leptolstatin