Efficacy of moxidectin against a strain of Haemonchus contortus resistant to ivermectin, a benzimidazole and a salicylanilide.
The efficacy of moxidectin at 0.2 mg kg-1 live body mass against the multiple anthelmintic resistant White River Krtz strain of H. contortus was determined and compared to that of ivermectin, a benzimidazole, a salicylanilide and levamisole. Moxidectin and levamisole were effective against this strain of H. contortus and reduced the arithmetic mean burdens of this parasite in the sheep by 99.98% and 99.59%, respectively, while the efficacy of ivermectin, albendazole and closantel was only 29.1%, 33.75% and 78.3%, respectively.
Oosthuizen
W T
WT
Rumevite Animal Care, Elarduspark, Republic of South Africa.
Erasmus
J B
JB
D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects*; D007559:Ivermectin / Q000627:therapeutic use; D007978:Levamisole / Q000627:therapeutic use; D018942:Macrolides; D012458:Salicylanilides / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; D012458:Salicylanilides; D007978:Levamisole; D007559:Ivermectin; C023342:closantel; D015766:Albendazole; C027837:moxidectin