In vitro activity of cycloguanil against African isolates of Plasmodium falciparum.
The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.
Basco
L K
LK
Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, Paris, France.
Ramiliarisoa
O
O
Ringwald
P
P
Doury
J C
JC
Le Bras
J
J
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008099:Liver / Q000469:parasitology; D016778:Malaria, Falciparum / Q000469:parasitology; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D002727:Proguanil; D014227:Triazines / Q000494:pharmacology*
D014227:Triazines; C026009:cycloguanil; D002727:Proguanil