In vivo effect of cyanate on serum and eye lens in rat.
Supplementation of cyanate in rats caused a significant decrease in serum GSH and increase in calcium and phosphate level both in serum and lens. Consequently, these changes led to induce acidosis uremia in serum and hypercalcemia and hyperphosphatemia in lens which may be possible causing factor for cataract.
Department of Chemistry, University of Gorakhpur, India.
V K
VK
Srivastava
N
N
Varshney
A
A
Jaiswal
D000138:Acidosis / Q000139:chemically induced; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003485:Cyanates / Q000633:toxicity*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D014511:Uremia / Q000139:chemically induced
D003485:Cyanates; D010710:Phosphates; D002118:Calcium