An open triple crossover study comparing water absorption from potable water, Lucozade, and Dioralyte using the stable isotope 18O.
Nine volunteer children aged 6-9 years were randomised in a Latin square design to receive one of three oral solutions [Lucozade (Beechams), Dioralyte (Rorer Pharmaceuticals), and potable water] labeled with the stable isotope 18O. After administration, breath CO2 was collected using a face mask for a period of 120 min. Mass spectrometric analysis gave the enrichments of 18O in CO2 at parts per million levels. Analysis showed the accumulation of the tracer (and, by inference, absorption from the gut) to be quickest from Dioralyte and slowest from Lucozade. We hope to use this technique to investigate the absorption of water from oral rehydration solutions in infants with dehydration due to gastroenteritis.
Booth Hall Hospital, Blackley, Manchester, England.
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Mecrow
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Miller
D001944:Breath Tests; D002648:Child; D004338:Drug Combinations; D004573:Electrolytes / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010103:Oxygen Isotopes; D015532:Rehydration Solutions / Q000008:administration & dosage / Q000378:metabolism*; D014867:Water / Q000008:administration & dosage / Q000378:metabolism*
C040673:Dioralyte; D004338:Drug Combinations; D004573:Electrolytes; D010103:Oxygen Isotopes; D015532:Rehydration Solutions; D014867:Water; D005947:Glucose