Measurement of nonspecific bronchial responsiveness in epidemiologic studies: methacholine challenge testing in the field.
Methacholine challenge testing is the most commonly used method for detecting and quantifying nonspecific bronchial hyperresponsiveness and has been used primarily in the clinical investigation of occupational asthma. This chapter reviews the rationale, methodology, and interpretation of this test which are relevant to conducting methacholine challenge testing outside the clinic ("in the field"). It also reviews the issues surrounding the methodology of methacholine challenge testing in general and, in particular, its use in epidemiologic studies.
Kennedy
S M
SM
Department of Medicine, University of British Columbia, Vancouver, Canada.
Contreras
G R
GR
D001249:Asthma / Q000503:physiopathology*; D015982:Bias; D016535:Bronchial Hyperreactivity / Q000175:diagnosis* / Q000453:epidemiology; D001985:Bronchial Provocation Tests / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D002985:Clinical Protocols / Q000592:standards; D015986:Confounding Factors, Epidemiologic; D015987:Effect Modifier, Epidemiologic; D004812:Epidemiologic Methods; D006801:Humans; D016210:Methacholine Chloride; D009784:Occupational Diseases / Q000175:diagnosis* / Q000453:epidemiology; D015203:Reproducibility of Results; D012307:Risk Factors
D016210:Methacholine Chloride