Evaluation of the efficacy of different antibiotics in inhibiting colonisation of Vibrio cholerae O1 in the rabbit intestine.
The efficacy of ciprofloxacin, norfloxacin and tetracycline in prevention of colonisation of V. cholerae O1 in the rabbit intestine were tested. V. cholerae O1 highly colonised the gut of rabbits which did not receive any antibiotic. All antibiotics tested inhibited the colonisation of V. cholerae O1 within the rabbit intestine. Moreover, ciprofloxacin and norfloxacin were found to be as effective as tetracycline suggesting that these drugs should be subjected to clinical trials for the treatment of cholera in comparison with tetracycline.
Chakrabarti
M K
MK
National Institute of Cholera and Enteric Diseases, Calcutta, India.
Bhattacharya
M K
MK
Sinha
A K
AK
Chatterjee
D C
DC
Bhattacharya
S K
SK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002771:Cholera / Q000382:microbiology; D002939:Ciprofloxacin / Q000494:pharmacology; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D007422:Intestines / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology; D011817:Rabbits; D013752:Tetracycline / Q000494:pharmacology; D014734:Vibrio cholerae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D013752:Tetracycline; D009643:Norfloxacin