The four seasons of anti-hypertensive therapy.
The development of anti-hypertensive therapy and its achievements over the last 40 years are reviewed. The following are identified as the still unanswered questions: the pharmacological treatment of mild hypertension; the limited efficacy of anti-hypertensive therapy in the reduction of the number of myocardial infarctions; the negative effect of some types of antihypertensive treatment on plasma lipids; the lack of efficacy of some drugs in reducing left ventricular hypertrophy; the difficulty in establishing the optimal levels of blood pressure and often the difficulty in achieving those levels.
Università di Roma la Sapienza, I Scuola di Specializzazione in Nefrologia, Roma, Italia.
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D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002309:Cardiology / Q000639:trends*; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D009203:Myocardial Infarction / Q000517:prevention & control
D000959:Antihypertensive Agents; D002784:Cholesterol