Identification of immunosuppressive components of a mushroom, Lactarius flavidulus.
Three metabolites having a suppressive effect on proliferation of mouse lymphocytes stimulated with mitogens such as concanavalin A (Con A) and lipopolysaccharide (LPS) were isolated from a mushroom, Lactarius flavidulus, and identified as geranylphenols, flavidulols A, B and C, respectively, which had previously been isolated from the same mushroom. The IC50 values of flavidulols A, B and C were found to be 8.9, 4.9 and 36.3 micrograms/ml against Con A-induced proliferation of mouse lymphocytes, and 6.7, 3.9 and 28.3 micrograms/ml against LPS-induced proliferation, respectively.
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
H
H
Fujimoto
Y
Y
Nakayama
M
M
Yamazaki
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification*; D008213:Lymphocyte Activation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology
D007166:Immunosuppressive Agents