Gastric axial forces in experimentally delayed and accelerated gastric emptying.
The aim of this study was to assess the relationship between altered axial forces and gastric emptying of solids by experimentally inhibiting or stimulating gastric axial forces by intraduodenal lipid or intravenous erythromycin, respectively. In 15 healthy volunteers, we simultaneously measured gastric emptying of solids by scintigraphy, gastroduodenal motility by manometry, and forces along the longitudinal axis of the distal stomach by an axial force transducer. When 25% of the radiolabel had emptied from the stomach, subjects (n = 5 in each group) received normal saline (controls), intraduodenal lipid, or intravenous erythromycin. The test period consisted of the infusion period (10 min) and the subsequent 30 min. Lipid significantly reduced and erythromycin increased axial forces compared with control (lipid: median 0.6 N [0-1.4 interquartile range (IQR)]; erythromycin: median 18.2 N (16.5-20.5 IQR); control: median 4.7 N (3.9-5.2 IQR); P < 0.01). Similarly, antral phasic pressure activities were different relative to control. Gastric axial forces correlated significantly with gastric emptying (Spearman rank correlation = 0.86; P < 0.01). These data are consistent with the hypothesis that axial forces affect gastric emptying of solids and suggest that measurement of axial forces provides an assessment of overall gastric propulsion during the emptying of solids.
Prather
C M
CM
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
Camilleri
M
M
Thomforde
G M
GM
Forstrom
L A
LA
Zinsmeister
A R
AR
D000328:Adult; D004386:Duodenum / Q000502:physiology; D004435:Eating; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007205:Indium Radioisotopes; D008055:Lipids / Q000494:pharmacology; D008297:Male; D008365:Manometry; D012044:Regression Analysis; D013270:Stomach / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D007205:Indium Radioisotopes; D008055:Lipids; D004917:Erythromycin