Effects of cocaine on fetal and postnatal development in mice.
The goal of the current investigation was to study the effect of in utero exposure of cocaine on fetal and postnatal development. 48 adult female NIH Swiss mice were used as experimental animal models. Each of the 24 mice were injected intraperitoneally with cocaine HCl at a daily dose level of 45 mg/kg (body weight). Each of the 24 control animals were daily injected with saline. One week after the treatment started, one male was introduced into each female cage. The day the vaginal plug was found was recorded as day one of pregnancy. Both cocaine treated and saline treated animals were subdivided into three subgroups each with 8 animals in each subgroup. Subgroup one was used to obtain midgestational (11 day) fetuses, subgroup two was used to obtain full term fetuses (18 day) and subgroup three was used to obtain pups. Individual fetal weights were taken and each fetus was examined for developmental anomalies. Midgestational fetuses exposed to cocaine had lower body weights than those of the controls. The full term fetuses, however, had similar weight in both experimental and control groups. The pups were weighed every 2 days from day 2 to day 16. The pups showed a slightly wider range of weights in the cocaine treated group as they matured to 16 days. All fetuses and pups revealed no soft tissue anomaly which, along with the weight data, supported our earlier findings.
Department of Physiology and Biophysics, Medical College of Ohio, Toledo.
P
P
Arpasi
J
J
Chakraborty
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000502:physiology; D005865:Gestational Age; D006128:Growth / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D012016:Reference Values
D003042:Cocaine