[Superselective intra-arterial chemotherapy in breast cancer].
Forty-two patients with locally advanced breast cancer (n = 8) or recurrent breast cancer (n = 34) received regional chemotherapy (mitoxantrone 25 mg/m2 per 24 h) via the internal mammary artery or other vessels of the subclavian artery. To prevent artery thrombosis 500-1000 U heparin per hour were administered i.v. Tumour perfusion was monitored by intra-arterial angio-CT. Remission rates (CR + PR) were 100% (primary breast cancer) and 89% (recurrent tumours), respectively. Intra-arterial chemotherapy was well tolerated. No complications were noted.
Radiologische Klinik, Universität Bonn.
J
J
Görich
I
I
Hasan
H
H
Sittek
J
J
Jakschik
H
H
Werner
H J
HJ
Hartlapp
M
M
Reiser
D000328:Adult; D000368:Aged; D000792:Angiography; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008323:Mammary Arteries; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000009:adverse effects; D008991:Monitoring, Physiologic / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D008942:Mitoxantrone
Superselektive intraarterielle Chemotherapie bei Mammakarzinomen.