Apoptosis and signal transduction: clues to a molecular mechanism.
Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiological response to changes in the extracellular environment that trigger the anti-proliferative state characteristic of apoptosis.
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
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Christakos
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D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D011494:Protein Kinases; D011519:Proto-Oncogenes; D015398:Signal Transduction; D014157:Transcription Factors
D014157:Transcription Factors; D011494:Protein Kinases; D002118:Calcium