Signal transduction by Fc receptors: the Fc epsilon RI case.
The family of proteins collectively known as Fc receptors (FcR) plays a variety of roles both in the initiation of the immune response and in its consequences. During the past five years the structure of these proteins and the genes that code for them have been largely elucidated. The most unexpected finding has been their extensive diversity. Considerable efforts are now being expended to define the molecular events initiated by these various FcR and these events are the focus of our review.
Beaven
M A
MA
Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Metzger
H
H
D000818:Animals; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000276:immunology; D006801:Humans; D010740:Phospholipases / Q000276:immunology; D017346:Protein Serine-Threonine Kinases / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE / Q000276:immunology*; D015290:Second Messenger Systems / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013329:Structure-Activity Relationship
D011961:Receptors, Fc; D017455:Receptors, IgE; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D010740:Phospholipases; D019204:GTP-Binding Proteins