Transferrin gene as a model for liver-specific gene expression.
The results obtained in the recent years have led to an understanding of the mechanisms controlling liver-specific gene expression. They indicate that this expression needs an appropriate combination of hepatocyte and ubiquitous transcriptional factors, interacting with cis-acting DNA elements, in a characteristic manner for each gene. However, a number of important questions about liver organogenesis and specific cell differentiation remain to be answered.
Unité d'Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France.
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Petropoulos
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Zakin
D000818:Animals; D004742:Enhancer Elements, Genetic; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000378:metabolism*; D009928:Organ Specificity / Q000235:genetics; D011401:Promoter Regions, Genetic; D014168:Transferrin / Q000235:genetics*
D014168:Transferrin