[The reduction of the extension and severity of experimental myocardial infarct in pigs with growth hormone. The preservation of the microcirculation].
Administration of hGH during the acute phase of experimental myocardial infarctions in pigs showed several aspects which clearly distinguished the treated group from the control one. In the first case the necrotic segment appeared considerably smaller than in the control group but also exhibit a qualitative different necrotic pattern in the histologic aspect, i.e. the infarcted area is shown itself reduced to isolated cells; scarce clusters of them interspersed where found within larger areas of preserved tissue. Affected cells have been defined as "injured fibres" according to their particular aspect which notably differs to the classic expected picture of a 25th day infarction and exhibits itself as an "arrested necrosis". A remarkable preservation of capillary vessels has also been found in the treated cases by a contrasting disappearance of the capillary bed in the control group. Ventricular contractility was also explored with ECHO B which showed significant differences between both groups: wall thinning of the ventricular wall in the affected area did not appear in treated cases and normal contractility in the same area reappeared a few hours after the infarction. Contractility was never restored in the control group. hGH main action is directed towards the preservation of the myocardial collagen matrix, helping to maintain the structural integrity of ventricular wall. There are, however, other possible effects on immunological aspects of the macrophages partially noticed, and to be disclosed in the future.
Pontificia Universidad Católica Argentina, Santa María de los Buenos Aires.
H E
HE
Castagnino
M E
ME
Jörg
F A
FA
Toranzos
C A
CA
Bordenave
M I
MI
Sarchi
R
R
Azcoaga
G
G
Rodríguez
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D013552:Swine
D013006:Growth Hormone
Reducción de la extensión y gravedad del infarto del miocardio experimental en cerdos con hormona de crecimiento. Preservación de la microcirculación.