[The effects of a cardioactive hypothalamic neurohormone on the isolated rat heart].
On the isolated perfused by Langendorf at heart the cardioactive hypothalamic neurohormone NG3a (2 x 10(-5) g/ml) significantly decreased the coronary flow rate; the effect persisted during 5-10 min, after that the second phase appeared which was expressed by the increase of coronary flow rate. The maximum effect was 122% compared with control. The second phase appeared in 30-45 min after infusion of NG3a. NG3a did not influence the heart rate, but sometimes (7.3% cases) during the maximum increase of coronary flow the bradyarrhythmia was registered. It has been concluded that NG3a influences directly the coronary vessels.
R M
RM
Srapionian
R O
RO
Karapetian
A A
AA
Galoian
T M
TM
Vinogradova
N A
NA
Sokolova
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D007028:Hypothalamic Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion / Q000379:methods; D051381:Rats
D007028:Hypothalamic Hormones
Issledovanie vliianiĭ kardioaktivnogo neĭrogormona gipotalamusa na izolirovannoe serdtse krysy.