Class I and II HLA typing after a 10 Gy-4 hour therapeutic total body irradiation.
Class I and II HLA typing was investigated before and at various intervals after a 10 Gy total body irradiation delivered over 4 h, prior to allogeneic bone marrow graft for various hematological malignancies, in 14 patients. A reliable class I HLA typing appeared to be possible in almost all cases 6-8 hours after the start of irradiation but was only possible in 5 patients after 24 h. Preliminary results with class II antigens might suggest a more marked "fragility" of this antigen class after irradiation. These results encourage the drawing of blood samples for HLA grouping as soon as possible after accidental whole-body irradiation.
Institut Gustave Roussy, Villejuif, France.
J M
JM
Cosset
C
C
Raffoux
M P
MP
Chaillet
G
G
Socie
E
E
Briot
J Y
JY
Follezou
E
E
Grimaud
B
B
Dubray
T
T
Girinski
D000059:Accidents; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000601:surgery; D011832:Radiation Injuries / Q000601:surgery; D013997:Time Factors; D014916:Whole-Body Irradiation
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II