Absolute configuration of L-methionine sulfoximine as a toxic principle in Cnestis palala (Lour.) Merr.
An unusual amino acid, L-methionine sulfoximine (1), has been isolated from the fresh seeds of Cnestis palala (Lour.) Merr. [Connaraceae]. The absolute configuration of the natural sulfoximine (1) was confirmed to be 2(S)-methionine S(S)-sulfoximine [(2S,SS)-2-amino-4-(S-methylsulfonimidoyl)-n-butanoic acid] by comparison of the [alpha]D value and IR spectrum with those of authentic samples obtained through the optical resolution of synthetic materials. Acute toxicity of the seeds of C. palala in a beagle dog was also studied.
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
I
I
Murakoshi
T
T
Sekine
K
K
Maeshima
F
F
Ikegami
K
K
Yoshinaga
Y
Y
Fujii
S
S
Okonogi
D000818:Animals; D004285:Dogs; D008297:Male; D008717:Methionine Sulfoximine / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D008968:Molecular Conformation; D010939:Plant Poisoning / Q000209:etiology*; D012639:Seeds / Q000737:chemistry*
D008717:Methionine Sulfoximine