Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography-mass spectrometry.
Medetomidine, atipamezole and midazolam in pig plasma were determined by liquid chromatography-mass spectrometry (LC-MS) with an atmospheric pressure chemical ionization interface system by the use of detomidine as an internal standard. The method was applied to studies of pharmacokinetic behaviour of these drugs.
Kanazawa
H
H
Kyoritsu College of Pharmacy, Tokyo, Japan.
Nishimura
R
R
Sasaki
N
N
Takeuchi
A
A
Takai
N
N
Nagata
Y
Y
Matsushima
Y
Y
D000316:Adrenergic alpha-Agonists / Q000493:pharmacokinetics; D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics; D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods* / Q000706:statistics & numerical data; D008401:Gas Chromatography-Mass Spectrometry; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D007093:Imidazoles / Q000097:blood / Q000493:pharmacokinetics*; D007700:Kinetics; D013058:Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D020926:Medetomidine; D008874:Midazolam / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D020926:Medetomidine; D008874:Midazolam