Loss of the 'azoospermia factor' (AZF) on Yq in man is not associated with loss of HYA.
We have typed 9 EBV cell lines from azoospermic or severely oligospermic patients for the expression of H-Y antigen, in order to test the hypothesis of the coincidence of AZF and HYA genes. Of nine patients with cytogenetically normal Y chromosomes, 7 could be tested for HYA expression and of these 6 were H-Y positive. Of the three patients showing Yq structural abnormalities, two could be tested for H-Y expression and one was negative, the other positive. These results therefore show no correlation between spermatogenic failure and the absence of HYA, thus separating the AZF locus from HYA.
Simpson
E
E
Clinical Research Centre, Harrow, Middlesex, UK.
Chandler
P
P
Goulmy
E
E
Ma
K
K
Hargreave
T B
TB
Chandley
A C
AC
D000328:Adult; D002460:Cell Line; D002869:Chromosome Aberrations; D017353:Gene Deletion; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D014998:Y Chromosome
D006182:H-Y Antigen