[The anti-infective properties of mammalian earwax].
The cerumen (earwax) of some mammals possesses antistaphylococcal, antimicrococcal and antiherpes activities. The cerumen of two thirds of individuals, irrespective of their species identity and sex, has antiviral properties. The mean chemotherapeutical index in the studied groups follows a significantly decreasing sequence: dogs, humans without signs of herpes infections, rabbits, and humans with clinically expressed herpes infection. Cerumen of almost 25% of humans of the compared groups displays the immunostimulating activity. The cerumen of all studied individuals contains yeast-like fungi. A suggestion is put forward that the products of their metabolism stimulate local release of interferon-like substances by the lymphoid tissue in the cerumen.
Sokolov
V E
VE
Ushakova
N A
NA
Chernova
O F
OF
Shubkina
A B
AB
Alimbarova
L M
LM
Barinskiĭ
I F
IF
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002571:Cerumen / Q000276:immunology* / Q000382:microbiology; D002522:Chlorocebus aethiops; D004285:Dogs; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D011817:Rabbits; D012996:Solutions; D013045:Species Specificity; D013997:Time Factors; D014709:Vero Cells
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D012996:Solutions
Ob antiinfektsionnykh svoĭstvakh ushnoĭ sery mlekopitaiushchikh.