Non-specific immunological abnormalities and association of autoimmune diseases in idiopathic portal hypertension. A study by questionnaire.
A large survey by questionnaire of idiopathic portal hypertension (IPH) in Japan disclosed that 11.9% of 160 cases were associated with one or two autoimmune diseases, and 26.3% of them disclosed hypergammaglobulinemia. Patients with IPH also frequently showed one or more autoantibodies in the serum, such as antinuclear or anti-smooth muscle antibodies. These findings overlapped frequently in the same patient. These data imply that immunological disturbance and/or chronic antigenic stimulation are related to the pathogenesis of IPH, though the exact immunological mechanisms remain unclear. It will be necessary to study more specific immunological reactions in IPH.
Saito
K
K
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Nakanuma
Y
Y
Takegoshi
K
K
Ohta
G
G
Obata
Y
Y
Okuda
K
K
Kameda
H
H
D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000453:epidemiology*; D006975:Hypertension, Portal / Q000453:epidemiology / Q000276:immunology*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires
D001323:Autoantibodies