[Inflammatory role of eosinophil in allergic reactions].
A role of eosinophil is thought to be an inflammatory effect, although it had been believed that the cell has a protective role by blocking mediators from the mast cell. Eosinophils release several kinds of basic and cationic proteins following receptor-mediated activation. These mediators gradually lead to tissue damage of the bronchi, skin, nerve, heart and other general organs. Bronchial asthma and eosinophilic pneumonia as well as hyper-eosinophilic syndrome is based on this pathogenesis. Potent therapy, including steroids, will be needed for long terms in these diseases with tissue eosinophilia.
Kimura
I
I
Internal Medicine II, Okayama University Medical School.
Takahashi
K
K
D001249:Asthma / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D001798:Blood Proteins / Q000378:metabolism; D015550:Cell Degranulation; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D011657:Pulmonary Eosinophilia / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D012260:Ribonucleases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases