Symptomatic sulfadiazine crystalluria in AIDS patients: a report of two cases.
As the incidence of toxoplasma encephalitis (TE) in AIDS patients increases, sulfadiazine/pyrimethamine combination therapy is broadly administered. Two cases of acute and chronic renal sulfadiazine crystallization with acute renal failure and nephrolithiasis are reported. Controlled alkalinization of the urine and high fluid intake are recommended for prophylaxis of crystalluria.
Hein
R
R
Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Germany.
Brunkhorst
R
R
Thon
W F
WF
Schedel
I
I
Schmidt
R E
RE
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D004359:Drug Therapy, Combination; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced*; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy*
D013411:Sulfadiazine; D011739:Pyrimethamine