Glial populations in the juvenile and adult Mongolian gerbil: relationship to spongiform degeneration of the ventral cochlear nucleus.
The gerbil cochlear nucleus is subject to a spongiform degeneration, the progression of which is dependent on auditory functional activity. The most affected region is the ventrolateral aspect of the caudal posterior ventral cochlear nucleus (PVCN). Lesion density and glial changes were quantified in this region for two age groups. Spongiform lesions increased significantly in area density from 4% in 60-day-old gerbils to 14% in 6-month-old gerbils. In spite of this significant increase in tissue damage, no gliosis was found. A significant age-related decrease in oligodendrocyte density was found in the PVCN.
Department of Otolaryngology, Head and Neck Surgery, University of California, Davis 95616.
B T
BT
Faddis
M D
MD
McGinn
D000161:Acoustic Stimulation; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000502:physiology; D001309:Auditory Threshold; D001933:Brain Stem / Q000254:growth & development / Q000502:physiology*; D003056:Cochlear Nerve / Q000254:growth & development / Q000502:physiology*; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D009457:Neuroglia / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure
D005904:Glial Fibrillary Acidic Protein