In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth.
Multiple exposures with cefotaxime in either Mueller-Hinton broth or cerebrospinal fluid had no effect on killing or the duration of postantibiotic effect (PAE) in Escherichia coli strains tested. However, upon multiple exposures in Mueller-Hinton broth, ciprofloxacin and gentamicin PAEs significantly decreased with a concomitant reduction in bacterial killing. A reduction in bacterial killing following multiple ciprofloxacin and gentamicin exposures was also seen with cerebrospinal fluid; however, the PAE was maintained.
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
J A
JA
Karlowsky
G G
GG
Zhanel
R J
RJ
Davidson
S R
SR
Zieroth
D J
DJ
Hoban
D002439:Cefotaxime / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002939:Ciprofloxacin / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development*; D005839:Gentamicins / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
D003470:Culture Media; D005839:Gentamicins; D002939:Ciprofloxacin; D002439:Cefotaxime