Interactions of Candida albicans with bacteria and salivary molecules in oral biofilms.
The yeast Candida albicans coaggregates with a variety of streptococcal species, an interaction that may promote oral colonization by yeast cells. C. albicans and Candida tropicalis are the yeasts most frequently isolated from the human oral cavity and our data demonstrate that both these species bind to Streptococcus gordonii NCTC 7869 while two other Candida species (Candida krusei and Candida kefyr) do not. Adherence of C. albicans was greatest when the yeast had been grown at 30 degrees C to mid-exponential growth phase. For 21 strains of C. albicans there was a positive correlation between the ability to adhere to S. gordonii and adherence to experimental salivary pellicle. Whole saliva either stimulated or slightly inhibited adherence of C. albicans to S. gordonii depending on the streptococcal growth conditions. The results suggest that the major salivary adhesins and coaggregation adhesins of C. albicans are co-expressed.
Holmes
A R
AR
Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand.
Cannon
R D
RD
Jenkinson
H F
HF
D001422:Bacterial Adhesion / Q000502:physiology; D018407:Bacterial Physiological Phenomena; D018441:Biofilms / Q000254:growth & development*; D002175:Candida / Q000502:physiology; D002176:Candida albicans / Q000254:growth & development / Q000502:physiology*; D044622:Dental Pellicle; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D012463:Saliva / Q000382:microbiology*; D013291:Streptococcus / Q000502:physiology