Alcohol- and aldehyde-dehydrogenase: modulation by biogenic amine metabolites, neuropeptides and psychoactive agents.
The results suggest the feasibility of metabolic and behavioral interrelationships between ethanol (ET), certain neurotransmitter substances and major metabolites, some neuropeptides and/or psychoactive agents. This was indicated by the in vivo and in vitro effects of such authentic compounds on certain ET-elicited behavioral responses and on hepatic ET and acetaldehyde metabolizing enzymes in rats and mice.
Department of Pharmacology and Toxicology, University of North Dakota School of Medicine, Grand Forks 58203.
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D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000428:Alcohol Drinking / Q000378:metabolism / Q000523:psychology; D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001679:Biogenic Amines / Q000378:metabolism / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D001679:Biogenic Amines; D009479:Neuropeptides; D011619:Psychotropic Drugs; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase