Clinical usefulness of continuous administration of Nocardia rubra cell wall skeleton (N-CWS) in diffuse panbronchiolitis (DPB).
Eight patients with diffuse panbronchiolitis (DPB) who had repeated intractable airway infections were continuously treated with Nocardia rubra cell wall skeleton (N-CWS), a biological response modifier. As a result, subjective symptoms were reduced in 6 patients. Antibiotics therapy could be discontinued completely in two patients and the dose of antibiotics could be reduced considerably in two other patients. No adverse reactions in relation to N-CWS were observed. These results suggest that N-CWS is effective in treating erythromycin-resistant DPB.
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
S
S
Ishioka
S
S
Hozawa
K
K
Hasegawa
T
T
Saito
M
M
Takaishi
M
M
Yamakido
D000328:Adult; D000368:Aged; D001988:Bronchiolitis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D017358:Cell Wall Skeleton / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D009615:Nocardia / Q000737:chemistry*; D012129:Respiratory Function Tests
D017358:Cell Wall Skeleton; D007155:Immunologic Factors; C044553:cell wall skeleton, Nocardia