Prediction of plasma concentrations of mianserin and desmethylmianserin at steady state from those after an initial dose of mianserin.
The relationships between the plasma concentrations of mianserin and desmethylmianserin at 18 h after initial dosing and those at steady state were studied in 19 depressed patients receiving 30 mg of mianserin at bedtime. Significant linear relationships were observed for mianserin, desmethylmianserin, and mianserin plus desmethylmianserin. The present study thus suggests that the plasma concentrations of these compounds after an initial dose of mianserin can be used for the prediction of an optimal dose.
Department of Neuropsychiatry, Hirosaki University Hospital, Japan.
K
K
Otani
K
K
Mihara
M
M
Okada
O
O
Tanaka
S
S
Kaneko
Y
Y
Fukushima
D000328:Adult; D000368:Aged; D000818:Animals; D003863:Depression / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*; D008875:Middle Aged
D008803:Mianserin; C056517:desmethylmianserin