Biochemical and morphological changes of spermatozoa in progestin-androgen injected rats.
Bimonthly injections (im) of medroxyprogesterone acetate (MPA, 5 mg/0.2 ml) and testosterone enanthate (TE, 2.5 mg/0.2 ml) to rats for 30 and 60 days induced oligospermia. The sperms from epididymis had defective metabolism, alterations in their morphology, viability and acrosome integrity. Thus this altered sperm function resulted in reduction in the fertility rate of MPA+TE treated animals.
Rao
M V
MV
Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, India.
Roy
G K
GK
D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D051381:Rats; D013076:Sperm Count / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
D013739:Testosterone; C004648:testosterone enanthate; D017258:Medroxyprogesterone Acetate