Antifertility effects in female rats immunized with human seminal plasma inhibin.
Adult female rats were actively immunized with sperm-coating protein (10.4 KDa) human seminal plasma inhibin (HSPI). Following 8 weeks of immunization at 2.5 micrograms and 5 micrograms doses of HSPI with Freund's complete adjuvant, antifertility effects were observed in 63% (5/8) and 88% (7/8) of animals, respectively. Estrous cycle was not affected in experimental group. Thus, the present study suggests the potential use of HSPI for immunocontraception in females.
Institute for Research in Reproduction (ICMR), Parel Bombay, India.
K S
KS
Hurkadli
V J
VJ
Vernekar
A R
AR
Sheth
D000818:Animals; D000917:Antibody Formation; D003269:Contraception, Immunologic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000276:immunology / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D012661:Semen / Q000737:chemistry; D014611:Vaccination
D007265:Inhibins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone