Low calorie unrestricted protein diet attenuates renal injury in hypertensive rats.
In the present investigation we researched the effects of low calorie diet without protein restriction on the renal function and glomerular injury of uninephrectomized spontaneously hypertensive rats. We compared the findings with those that occurred in two different groups of uninephrectomized spontaneously hypertensive rats: one treated with oral hydralazine (10 mg/kg per day) and a second fed regular food. The low calorie diet and hydralazine treatment significantly reduced intra-arterial blood pressure in each group (p < 0.05 and p < 0.001, respectively). The control group showed at the end of the experiment a slight but not significantly different increase in the intra-arterial blood pressure. Low calorie diet was more effective in protecting the kidney function. Creatinine clearance after treatment was significantly higher in uninephrectomized spontaneously hypertensive rats on a low calorie diet than in either the hydralazine-treated or control groups (p < 0.01). The 24-hour urinary protein excretion in the low calorie diet group was significantly lower than in the control group (p < 0.05) and lower but not statistically different from the hydralazine-treated group. The mean glomerular injury index of the remaining kidney in the low calorie diet group was lower than in either the hydralazine-treated or control groups (p < 0.05), and the mean mesangial expansion index in the low calorie diet group was significantly lower than in the control group (p < 0.05). The favorable effect of low calorie diet on renal function was independent of protein restriction or sodium and potassium content.(ABSTRACT TRUNCATED AT 250 WORDS)
Reisin
E
E
Department of Medicine, Louisiana State University, New Orleans 70112.
Azar
S
S
DeBoisblanc
B P
BP
Guzman
M A
MA
Lohmann
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004038:Diet, Reducing; D004044:Dietary Proteins / Q000494:pharmacology*; D002149:Energy Intake; D006830:Hydralazine / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009392:Nephrectomy; D009929:Organ Size; D011507:Proteinuria / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR / Q000033:anatomy & histology*
D004044:Dietary Proteins; D006830:Hydralazine