[Efficacy of hemoglobin-Alc, fructosamine, and 1,5-anhydroglucitol in community screening for diabetes mellitus].
To evaluate the efficacy of hemoglobin-Alc, fructosamine, and 1,5-anhydroglucitol tests in screening for diabetes mellitus in communities, the sensitivity and the specificity of these tests were observed on the island of Ojika, Goto islands, Nagasaki prefecture Japan. A 75 gram glucose tolerance test was performed simultaneously on every participant, and WHO diabetes mellitus criteria were used to classify individuals. A total of 554 males and 820 females, older than 34 years, participated in the examination, representing a response rate of 42% and 52% respectively, and 86 were classified as diabetic. The sensitivity and the specificity of several screening levels were determined for each test. Each of the tests attained greater than 70% sensitivity and specificity simultaneously, but could not achieve greater than an 80% level simultaneously. If screening levels are selected for a sensitivity of as low as 50%, it is possible to produce a high specificity of 97-98%. These results provide valuable information for the planning of efficient diabetes mellitus detection programs in communities.
Department of Public Health, Jichi Medical School.
M
M
Nagai
K
K
Sakata
H
H
Yanagawa
H
H
Sueta
T
T
Tanaka
S
S
Shirahama
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003153:Community Health Services; D003847:Deoxyglucose / Q000097:blood*; D003920:Diabetes Mellitus / Q000517:prevention & control*; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis*; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged
D003847:Deoxyglucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; C006584:1,5-anhydroglucitol