[Hematologic response to low dose natural interferon-alpha in a case of CML with myelo-megakaryoblastic crisis].
A 59-year-old female with splenomegaly was admitted in November, 1989. Her WBC was 7,900/microliters with 51% myeloblasts and 10% megakaryoblasts. Analysis of the surface markers showed that 56.5% were CD13 positive and 66.8% carried platelet GpIIb/IIIa. The Ph1 chromosome was 100% positive. VPM therapy was started but proved ineffective, as was subsequent MCNU therapy. The patient was given intramuscular human lymphoblastoid interferon-alpha (1.2 million IU daily) for more than 20 months. She had improved to the accelerated phase after INF-alpha therapy for 13 months. Thus there appears to be a relationship between INF-alpha and myelo-megakaryoblastic crisis.
Fourth Department of Internal Medicine, Tokai University School of Medicine.
H
H
Nozaki
T
T
Usui
K
K
Yamauchi
N
N
Kobayashi
Y
Y
Nakamura
K
K
Watanabe
T
T
Nagao
S
S
Arimori
D001752:Blast Crisis / Q000473:pathology*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000473:pathology / Q000628:therapy*; D007958:Leukocyte Count; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged
D016898:Interferon-alpha