Long term follow up of haemophilic arthropathy treated by Au-198 radiation synovectomy.
Intra-articular injection of Au-198 (gold synoviorthesis) has been used in the treatment of repeated haemarthroses of the elbows, knees, or ankles in 64 haemophiliacs. These patients had continued to have joint haemorrhages despite appropriate, episodic, substitutive therapy over a period of more than six months. Follow-up for an average period of 14 years in one knee in 38 male haemophiliacs showed 8 good, 23 fair, and 7 poor results with regard to their joint scores. It is concluded that Au-198 is an effective agent for radiation synovectomy, particularly in the early stages of the disease with minimal radiographic changes. It appears to reduce the incidence of haemarthrosis and to slow the rate of evolution of radiographic changes.
Haemophilia Unit, La Paz Hospital, Madrid, Spain.
E C
EC
Merchan
M
M
Magallon
J
J
Martin-Villar
E
E
Galindo
F
F
Ortega
J A
JA
Pardo
D000293:Adolescent; D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D006050:Gold Radioisotopes / Q000627:therapeutic use*; D006395:Hemarthrosis / Q000150:complications / Q000532:radiotherapy*; D006467:Hemophilia A / Q000150:complications; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D008297:Male; D011879:Radiotherapy Dosage; D016059:Range of Motion, Articular; D013583:Synovial Membrane / Q000528:radiation effects*; D013585:Synovitis / Q000209:etiology / Q000532:radiotherapy*
D006050:Gold Radioisotopes