[Urticaria-angioedema type of sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs; diagnostic value of anamnesis and challenge tests with acetylsalicylic acid in detecting this sensitivity].
The aim of the paper was to estimate the value of challenge tests with acetylsalicylic acid in diagnosis of ASA-induced urticaria. The study was performed in 71 persons with suspected urticaria/angioedema type of sensitivity to ASA. The anamnesis confirmed sensitivity in 67 examined patients (94.4%) and showed that the sensitive patients usually suffered from extensive urticaria (37 persons, i.e. 55.5%) after ingestion of ASA. Eight persons (12%) reacted with loss of consciousness and 4 (6.0%) with oedema of the larynx. Oral challenge test with acetylsalicylic acid was performed in 53 examined persons, in 49 (92.4%) of which it was positive. Threshold doses of acetylsalicylic acid ranged from 40 to 300 mg. In 11 persons the test was repeated and in 8 performed three times. It was observed that both the threshold acetylsalicylic acid doses and the time of appearance of the sensitivity symptoms were changeable. All ASA-sensitive reacted to indomethacin in the similar way as to ASA. Paracetamol, on the other hand, was well tolerated by all 25 tested patients with urticaria/angioedema type of sensitivity to ASA.
Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.
I
I
Grzelewska-Rzymowska
M
M
Szmidt
J
J
Rozniecki
D000293:Adolescent; D000328:Adult; D000799:Angioedema / Q000139:chemically induced* / Q000276:immunology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014581:Urticaria / Q000139:chemically induced* / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
Porzywkowo-obrzekowa postać nadwrazliwości na aspiryne i inne niesteroidowe leki przeciwzapalne; wartość wywiadu i testów ekspozycyjnych z kwasem acetylosalicylowym w ujawnianiu tej nadwrazliwości.