Hypoalgesic effect of EMLA and lidocaine gel applied on human oral mucosa: quantitative evaluation by sensory and pain thresholds to argon laser stimulation.
Sensory and pain thresholds to argon laser stimulation were used to evaluate the analgesic efficacy and duration of a eutectic mixture of local anesthetics (EMLA) and a 2% lidocaine gel applied topically on the oral mucosa. Application of EMLA for 2 min on the tongue and gingiva increased the pain thresholds by 92.8% and 63.4% respectively. Corresponding values for lidocaine gel were 53.6% and 21.9%. Standardized variation of the EMLA application period (2, 5, and 15 min) produced significantly different analgesic profiles on the tongue but not on the gingiva. Application of EMLA for 5 and 15 min on the tongue and for 2, 5, and 15 min on the gingiva increased the pain thresholds to a predefined analgesic level (2.15 W) for 2 to 25 min. The present experimental model for assessment of oral mucosa pain is suggested to be well-suited for investigations of intraoral analgesia.
Svensson
P
P
Department of Prosthetic Dentistry and Stomatognathic Physiology, Royal Dental College, Aarhus, Denmark.
Bjerring
P
P
Arendt-Nielsen
L
L
Kaaber
S
S
D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D007834:Lasers; D008012:Lidocaine / Q000008:administration & dosage*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009061:Mouth Mucosa; D010147:Pain Measurement; D017288:Pain Threshold; D011318:Prilocaine / Q000008:administration & dosage*; D012684:Sensory Thresholds; D013997:Time Factors
D000779:Anesthetics, Local; D004338:Drug Combinations; D005782:Gels; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine