[Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-formamidines corresponding alkyl esters with antianaphylactic activity].
A lot of N-(2-carboxy-thieno[2,3-b]pyridin-3-yl)formamidines especially in form of their amine salts--were synthesized by reaction of 3-amino-thieno[2,3-b]pyridine-2-carboxylic acids with dimethylformamide/phosphoroxide chloride or by reaction of 4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3- oxazines with amines. Carboxylic acid alkylesters of this structure were yielded from 3-amino-thieno[2,3-b]pyridine-2-carbonic acid alkylesters by reaction with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The compounds showed antianaphylactic activity.
Fachbereich Biowissenschaften der Universität Leipzig.
G
G
Wagner
H
H
Vieweg
J
J
Prantz
S
S
Leistner
D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000578:Amidines; D010972:Platelet Activating Factor; D011725:Pyridines
Synthese von N-(2-Carboxy-thieno[2,3-b]pyridin-3-yl)-formamidinen und entsprechender Alkylester mit antianaphylaktischer Wirkung.