[A new treatment method of idiopathic renal bleeding--experimental and clinical study of renal arterial infusion of a mixture with autologous blood and iopamidol].
The efficacy and safety of a new treatment of idiopathic renal bleeding, by infusing a mixture of autologous blood and Iopamidol into the renal artery was studied experimentally and clinically. When using a rabbit in our experiment we injected a mixture of Iopamidol (370mgI/ml) and autologous blood in a volume of 1 ml into the renal artery. In a case study using 51Cr-labelled RBC, 3% of the RBC was retained in the kidney for 30 minutes. In a histological study RBCs were found in peritubular capillaries for 60 minutes after injection, and no organic changes were found in the glomerulus and tubular cells. In 6 patients with idiopathic renal bleeding, a mixture of patients blood (10ml) and Iopamidol (10ml) was infused into the affected renal artery. In all cases the bleeding side was left. In 5 cases even microscopic hematuria was not found during the follow up period. No complications such as the increase of serum creatinine and BUN has occurred. The mechanism of the disappearance of hematuria is still unclear, however, temporary occlusion of the renal microcirculation has a close relationship to the hemostasis.
Department of Radiology, Osaka University Medical School.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001804:Blood Transfusion, Autologous; D006470:Hemorrhage / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007479:Iopamidol / Q000008:administration & dosage*; D007674:Kidney Diseases / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D012077:Renal Artery
D007479:Iopamidol