[Activity of 5'-nucleotidase from thymus and tumors upon administering bradykinin to tumor-bearing mice].
Activity of 5'-nucleotidase was inhibited in thymus tissue of tumor-bearing mice; bradykinin (1 mg/kg body weight) increased the enzymatic activity 2.0-2.2-fold. Administration of bradykinin led to inhibition of allogenic Crocker's sarcoma growth and to stimulation of syngeneic mastocytoma P-815 growth, which was inoculated into noninbred and BALB/c mice, respectively. Hence, bradykinin activated 5'-nucleotidase in Crocker's sarcoma and did not affect the enzymatic activity in tumor P-815. This suggests that activity of 5'-nucleotidase is of importance in evaluation of the thymus tissue state as well as it demonstrates the tumoral tissue sensitivity to bradykinin.
Sukhanova
G A
GA
Potanova
G V
GV
Narbutovich
S A
SA
D015720:5'-Nucleotidase / Q000037:antagonists & inhibitors*; D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology*; D013950:Thymus Gland / Q000187:drug effects / Q000201:enzymology*
D015720:5'-Nucleotidase; D001920:Bradykinin
Aktivnost' 5'-nukleotidazy timusa i opukholi pri vvedenii bradikinina mysham-opukholenositeliam.