Role of T-cell antigen receptors in rheumatic disease.
The initiation and perpetuation of many rheumatic diseases is believed to be mediated by specific T-cells activated by an unknown antigenic peptide present on the surface of antigen presenting cells (APC). The T-cell antigen receptor (TCR) plays a central role in the recognition of antigen and subsequent T-cell activation. It is thought that a selective TCR repertoire may contribute to the immunopathogenesis of certain inflammatory rheumatic diseases. In this review recent progress in our understanding of TCR usage and their role in a variety of rheumatic diseases will be discussed. In addition, novel immunotherapeutic strategies based on a better understanding of the molecular mechanisms of antigen recognition will be reviewed.
Department of Rheumatology, Royal North Shore Hospital, University of Sydney, NSW, Australia.
Z G
ZG
Li
N
N
Manolios
D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D012216:Rheumatic Diseases / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy
D011948:Receptors, Antigen, T-Cell