Responses of cultured adult monkey trigeminal ganglion neurons to capsaicin.
The sensitivity of adult primate (Macaca mulatta) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19 nA) upon drug application measured at -60 mV. Capsaicin-sensitive neurons had longer action potential (AP) durations than capsaicin-insensitive neurons.
Department of Pharmacology, Oregon Health Sciences University, Portland 97201.
S L
SL
Ingram
M E
ME
Martenson
T K
TK
Baumann
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000187:drug effects*; D012668:Trigeminal Ganglion / Q000166:cytology / Q000187:drug effects*
D002211:Capsaicin