The effect of intravenous omeprazole on the gastric and duodenal potential difference and pH in healthy subjects.
The effect of intravenous omeprazole (40 and 80 mg) on the gastric and duodenal potential difference (PD) and pH was investigated in 9 healthy volunteers. Gastric PD and pH increased significantly (p < 0.05) following omeprazole, and the increases were equal following the two doses. No changes were found in duodenal PD or pH. It has been claimed that gastric PD changes following acid secretion inhibition with cimetidine and glucagon might be due to changes in the parietal cell surface area. Omeprazole causes no changes in the parietal cell structure, and the changes in gastric PD following omeprazole might therefore be ascribed to changes in mucosal electrophysiologic transport or resistance.
Department of Surgery, Hørsholm Hospital, Denmark.
E
E
Rubinstein
L
L
Højgaard
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D004386:Duodenum / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D009853:Omeprazole / Q000008:administration & dosage / Q000494:pharmacology*; D010295:Parietal Cells, Gastric / Q000187:drug effects
D009853:Omeprazole