A double-blind fluoroscopic study of cisapride on gastrointestinal motility in patients with functional dyspepsia.
Twenty patients with functional dyspepsia were referred for radiologic examination and, upon confirmation of a hypomotile stomach, were given either 10 mg cisapride or placebo in a double-blind manner (10 patients per group). The movement of a 250-ml barium meal was assessed by means of television fluoroscopy performed at regular time intervals. Cisapride significantly improved antral contractility and enhanced gastric emptying compared with placebo. Deep peristaltic waves occurred over the entire small bowel, and motility and small-bowel transit time of the barium meal were significantly increased in the cisapride group compared with the placebo group. The study demonstrates that when a carefully defined protocol is observed, fluoroscopy following barium ingestion offers considerable potential in the assessment of gastrointestinal motility.
Dept. of Radiology and Medical Imaging, University Hospital Antwerp, Belgium.
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H
Degryse
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A
De Schepper
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M
Verlinden
D001466:Barium Sulfate; D020117:Cisapride; D004311:Double-Blind Method; D004415:Dyspepsia / Q000188:drug therapy* / Q000503:physiopathology; D005471:Fluoroscopy; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D011706:Pyloric Antrum / Q000187:drug effects / Q000502:physiology
D010880:Piperidines; D001466:Barium Sulfate; D020117:Cisapride