Antimicrobial activity of two bactenecins against spirochetes.
Bac5 and Bac7 are antimicrobial peptides of bovine neutrophils that act on enteric gram-negative bacteria. We report here that these two peptides immobilize and kill Leptospira interrogans and Leptospira biflexa with MBCs of 6 to 25 micrograms/ml. Conversely, although both peptides bind to Borrelia burgdorferi, the organism is resistant to their action.
Scocchi
M
M
Department of Biochemistry, Biophysics and Macromolecular Biochemistry, University of Trieste, Italy.
Romeo
D
D
Cinco
M
M
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D015748:Borrelia burgdorferi Group / Q000187:drug effects* / Q000378:metabolism; D007919:Leptospira / Q000187:drug effects* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; C056454:bactenecin