Potential agonist action of the interleukin-1 receptor antagonist protein: implications for treatment of women.
The interleukin-1 receptor antagonist protein (IRAP) caused a concentration-related increase in prostaglandin production by human decidual cells. The degree and time course of this stimulatory action were identical to those induced by interleukin 1 beta (IL-1 beta). IRAP had no inhibitory action on IL-1 beta stimulation of decidual prostaglandin production and at high concentrations had an additive effect. We believe that this represents the first description of a potential agonist action of IRAP and suggests caution in treatment of women with this substance.
Mitchell
M D
MD
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City.
Edwin
S S
SS
Silver
R M
RM
Romero
R J
RJ
D002478:Cells, Cultured; D003656:Decidua / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D009994:Osmolar Concentration; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*
D007375:Interleukin-1; D011453:Prostaglandins; D017472:Receptors, Interleukin-1