Fibrodysplasia ossificans progressiva and synovial chondromatosis.
Two cases of an unusual association-fibrodysplasia ossificans progressiva and synovial chondromatosis-in non-related children are presented. This association does not seem coincidental and raises several questions about the pathogenesis. A genetic hypothesis related to G proteins is proposed. This is supported by the fact that such abnormalities have been demonstrated in pseudohypoparathyroidism and fibrous dysplasia; these diseases can also be associated with fibrodysplasia ossificans progressiva.
Hôpital Saint Vincent de Paul, Paris, France.
G
G
Kalifa
C
C
Adamsbaum
C
C
Job-Deslande
J
J
Dubousset
D000293:Adolescent; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging; D002648:Child; D015838:Chondromatosis, Synovial / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007866:Leg / Q000000981:diagnostic imaging; D009221:Myositis Ossificans / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography; D012785:Shoulder Joint / Q000000981:diagnostic imaging