The immunoregulatory roles of transforming growth factor beta.
Transforming growth factor-beta is a 25 kD polypeptide produced by both healthy and neoplastic cells. This cytokine effects the introduction of immune response, but its exact mechanism remains to be elucidated. In this paper the immuno-regulatory role of this cytokine on both the immunocompetent cells and accessory molecules is discussed. The growth factor-induced up and down regulation of the immune response suggest that transforming growth factor-beta can done some extent modulate certain pathological conditions, and hence suppressed production of this growth factor has potential benefits for bimodal immunotherapy.
Sosroseno
W
W
Department of Dental Public Health, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia.
Herminajeng
E
E
D006801:Humans; D007107:Immune System / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000276:immunology*
D016212:Transforming Growth Factor beta