Insulin resistance in three dogs with hypothyroidism and diabetes mellitus.
Insulin resistance resolved in 3 dogs with hypothyroidism and diabetes mellitus after treatment with sodium levothyroxine. A thorough diagnostic evaluation failed to identify any other cause of insulin resistance in these dogs. Hypothyroidism was diagnosed in each dog on the basis of clinical signs, physical findings, hyperlipidemia, and results of thyrotropin or thyrotropin-releasing hormone stimulation test. Hypoglycemia was documented in each dog within 2 weeks of starting sodium levothyroxine administration. The insulin dosage was decreased by 60 to 62% during the ensuing months and good glycemic control was obtained at these lower insulin dosages in all dogs. These findings would suggest hypothyroidism-induced insulin resistance in these dogs.
Veterinary Medical Teaching Hospital, Department of Medicine, University of California, Davis 95616.
S L
SL
Ford
R W
RW
Nelson
E C
EC
Feldman
D
D
Niwa
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007333:Insulin Resistance; D008297:Male; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D013974:Thyroxine