3-Triazenopyrroles: synthesis and antineoplastic activity.
Some 3-triazenopyrroles were prepared by coupling 3-diazopyrroles and secondary amines. In preliminary in vitro screening tests derivatives 3 showed to be cytotoxic and exhibited mutagenic effects.
Dattolo
G
G
Istituto Farmacochimico, Facoltà di Farmacia, Università degli Studi di Palermo.
Cirrincione
G
G
Almerico
A M
AM
Aiello
E
E
Grimaudo
S
S
Diana
P
P
Rausa
L
L
Dusonchet
L
L
Crosta
L
L
Tolomeo
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D005622:Friend murine leukemia virus; D007928:Lethal Dose 50; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011758:Pyrroles; D014227:Triazines