Dopamine agonist treatment of antegrade amnesia from a mediobasal forebrain injury.
We studied the persistent antegrade memory impairment in a woman whose brain had been surgically impaled, leaving a 1-cm-wide mediobasal tract of encephalomalacia that extended just anterior to the septal nuclei and medial to the nucleus accumbens. In a blinded, controlled, alternating repeated-measures protocol, bromocriptine significantly improved her verbal learning, functional memory, and daily recall, perhaps by acting on neurons that had been disconnected from the ventral tegmental tract's dopaminergic inputs.
Dobkin
B H
BH
School of Medicine, Department of Neurology, University of California, Los Angeles 90024-6975.
Hanlon
R
R
D000328:Adult; D000647:Amnesia / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D001930:Brain Injuries / Q000150:complications*; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009483:Neuropsychological Tests; D016548:Prosencephalon / Q000293:injuries*; D014888:Wechsler Scales
D001971:Bromocriptine