[In vivo resistance of Plasmodium falciparum to chloroquine in Anjouan (Comoros)].
An in vivo study of P. falciparum sensitivity to chloroquine was conducted at Anjouan island (République fédérale islamique des Comores) from December 1990 to March 1991. The 27 patients included in the study were given chloroquine at a dose regimen of 25 mg/kg over 3 days and were followed up 7 days. Six patients (22.2%) still harboured parasites up to day 7, thus showing a RII/RIII level of resistance. This is likely related to an increased chloroquine consumption by the inhabitants of this island since 1987.
Feillet
N
N
Hôpital de Domoni, Anjouan, République fédérale islamique des Comores.
Agnamey
P
P
Brasseur
P
P
Druilhe
P
P
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D017507:Comoros; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*
D002738:Chloroquine
Résistance in vivo à la chloroquine de Plasmodium falciparum à Anjouan (Comores).