Turning DNA replication on and off.
DNA replication is coupled to cell cycle progression at a major regulatory point in the G1 phase of the cell cycle. At this point, the catalytic subunit of a protein kinase (encoded by the CDC28 gene in budding yeast or the homologous CDC2 gene in other eukaryotes) is activated by binding to a positively acting regulatory subunit, a cyclin. Recent research has revealed evidence for two pathways that might connect these kinases to the proteins that replicate DNA: activation of an essential replication factor, or removal of the block that limits genome duplication to once per cell cycle.
Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
J M
JM
Roberts
D002453:Cell Cycle; D016213:Cyclins; D004261:DNA Replication / Q000502:physiology*; D005057:Eukaryotic Cells; D011494:Protein Kinases / Q000502:physiology*
D016213:Cyclins; D011494:Protein Kinases