Capillary zone electrophoresis and micellar electrokinetic capillary chromatography of some non-steroidal antiinflammatory drugs (NSAIDs).
The possibilities of capillary electrophoresis (CE) and micellar electrokinetic capillary chromatography (MEKC) were investigated for the qualitative analysis of some non-steroidal antiinflammatory drugs. In CE the influence of the pH of the buffer and its ionic strength were investigated for a test mixture of six compounds. Also the influence of organic modifiers was studied. The best conditions were applied to the separation of 15 drugs. In MEKC the influence of the concentration of SDS in buffers with pH ranges of 8.0-9.0 was investigated. The influence of an organic modifier, namely acetonitrile was discussed, whereby an interesting phenomenon of change in retention behaviour was noted. A combination of CE and MEKC allows the separation of the 15 above-mentioned compounds and forms an interesting alternative to HPLC.
Laboratories for Drug Quality Control and Medicinal Chemistry, U.G., Gent, Belgium.
M G
MG
Donato
E
E
Van den Eeckhout
W
W
Van den Bossche
P
P
Sandra
D000097:Acetonitriles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002845:Chromatography / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004586:Electrophoresis / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration
D000097:Acetonitriles; D000894:Anti-Inflammatory Agents, Non-Steroidal; C032159:acetonitrile