[Eosinophil kinetics].
The in vivo kinetics of autologous 111In-oxine labeled eosinophils were studied in 3 patients with reactive eosinophilia. Organ distribution and life span of 111In-oxine labeled eosinophils were evaluated. The disappearance curve of the labeled eosinophils showed two exponential components in all cases. Between these two factors, there was a slightly increase of radioactivity, suggesting the presence of recirculation. Radioactivity in the spleen, the liver and the bone marrow were observed 5 minutes after the infusion, suggesting the presence of marginal pool in these organs. Radioactivity in the spleen was increased rapidly during 1 and 24 hours after the infusion. Sequestration and/or destruction of increased eosinophils may exist in the splenic pool. The granulocyte turnover rate in eosinophilia was less than in CML or chronic neutrophilia. The results indicate that the migration of eosinophils is less active than that of neutrophils.
Department of Internal Medicine, Fukushima Prefectural Ono Hospital.
M
M
Konno
S
S
Matsuda
S
S
Kariyone
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002478:Cells, Cultured; D004802:Eosinophilia / Q000097:blood; D004804:Eosinophils / Q000166:cytology*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007553:Isotope Labeling; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood; D007958:Leukocyte Count; D008099:Liver / Q000166:cytology; D008297:Male; D013154:Spleen / Q000166:cytology
D007205:Indium Radioisotopes