Gastric vascular ectasia in cirrhosis.
Eight cases of upper gastro-intestinal bleeding associated with liver cirrhosis are reported in this paper. Morphological studies revealed gastroduodenal ulceration with severe vascular changes in the mucosa and submucosa layer. Capillary dilatation was seen in the superficial region of the mucosa. Thick-walled and tortuous vessels similar to angiodysplasia were noted in the submucosa. The latter vessels were surrounded by scar-like connective tissue considerably thickening the gastric submucous layer. It is assumed that scar-like thickening of the submucous layer surrounding the tele-angiectatic vessels causes microcirculatory disorders thus giving rise to bleeding ulcers.
Department of Pathology, János Hospital, Budapest, Hungary.
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M
Balázs
D000328:Adult; D000368:Aged; D002196:Capillaries / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000098:blood supply*; D014664:Vasodilation