Expression of E-cadherin in embryogenetic ingression and cancer invasion.
Homophilic interactions of E-cadherin serve the organization of embryonic and adult epithelia and counteract cancer invasion. The role of E-cadherin as an invasion-suppressor molecule has been demonstrated cancer. Regulation of embryonic ingression and cancer invasion via E-cadherin occurs at transcriptional, translational and post-translation levels.
Department of Radiotherapy and Nuclear Medicine, University Hospital, Ghent, Belgium.
M
M
Mareel
M
M
Bracke
F
F
Van Roy
L
L
Vakaet
D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004622:Embryo, Mammalian / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*
D015820:Cadherins