Copperglycinate protects mice exposed to various doses of gamma radiation.
Mice administered with various doses of copperglycinate (= glycine copper complex = GC) 15 min before exposure to various doses of gamma radiation showed an increased survival as compared to the non-drug treated irradiated control. It was also observed that 750 mg/kg body weight of GC was superior to the 500 and 1000 mg/kg body weight of GC as is evidenced by higher number of survivors in this group. The free radical scavenging activity of GC increased linearly with increasing drug dose.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India.
Ganapathi
N G
NG
Unnikrishnan
M K
MK
D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D016166:Free Radical Scavengers; D005720:Gamma Rays; D005998:Glycine / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000627:therapeutic use* / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D013047:Specific Pathogen-Free Organisms
D003037:Cobalt Radioisotopes; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D011837:Radiation-Protective Agents; C018493:cupric glycinate; D005998:Glycine