[The effect of intracellular pH on radiation damage to mammalian cells].
In experiments with Chinese hamster cells and Ehrlich ascites tumor cells it has been shown that a decrease in intracellular pH from 7.0 to 6.0, produced by 0.1 M phosphate buffer, ameliorates the radiation injury to cells (DMF = 1.35) with respect to their clonogenic capacity and induction of chromosome aberrations. The rate of repair of DNA single-strand breaks, within the pH range under study, is invariable.
A A
AA
Waĭnson
S M
SM
Ershova
I L
IL
Lapidus
T A
TA
Fadeeva
T E
TE
Fomenkova
N L
NL
Shmakova
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics; D002460:Cell Line; D002478:Cells, Cultured / Q000528:radiation effects; D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000528:radiation effects; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D006863:Hydrogen-Ion Concentration; D011833:Radiation Injuries, Experimental / Q000235:genetics / Q000517:prevention & control*; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D003037:Cobalt Radioisotopes; D004277:DNA, Single-Stranded
Vliianie vnutrikletochnogo pH na radiatsionnoe porazhenie kletok mlekopitaiushchikh.