[Immune tolerance in Masugi nephritis].
Induction of immunotolerance was studied in the autologous phase of experimental rabbit glomerulonephritis. The glomerulonephritis was induced by intravenous injection of duck anti-rabbit glomerular basement membrane globulin into rabbits. One single intravenous injection of that nephrotoxis immunoglobulin (20 mg/kg body weight) into rabbits was followed by glomerulonephritis with glomerular hypercellularity and proteinuria. Another group of rabbits was pretreated on their first day of age, using 1.5 mg/animal of immunoglobulin from duck. Nephritis did not grow manifest when the animals received another injection (20 mg/kg body weight), after eight weeks. Passive (intracutaneous) Arthus reaction (triggered by duck immunoglobulin) was recordable with equal intensity from either group.
St. Josef-Hospital, Universitätskinderklinik Bochum, Deutschland.
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D000818:Animals; D000831:Animals, Newborn; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D004372:Ducks; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology*; D007108:Immune Tolerance; D007116:Immunization, Passive; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011817:Rabbits
Immuntoleranz bei der Masugi-Nephritis.