Reduced responses of peripheral blood lymphocytes to heat-denatured food antigens in food-sensitive atopic dermatitis.
Although some patients with food-sensitive atopic dermatitis exhibit allergic symptoms to certain raw foods, they do not exhibit or scarcely exhibit allergic symptoms to boiled or cooked foods. In this study, although peripheral blood mononuclear cells responded to raw food antigens (ovalbumin or bovine serum albumin), the proliferative responses of peripheral blood mononuclear cells were reduced in heat-denatured food antigen-stimulation, in the hen egg- or cow milk-sensitive patients with atopic dermatitis who did not exhibit or scarcely exhibited allergic symptoms to the boiled or cooked foods although the patients exhibited allergic symptoms to the raw foods. Our results show that proliferative responses of peripheral blood mononuclear cells to heat-denatured food antigens are good parameters for diet counseling in food hypersensitivity.
Kondo
N
N
Department of Pediatrics, Gifu University School of Medicine, Japan.
Agata
H
H
Fukutomi
O
O
Nishida
T
T
Kameyama
T
T
Fujii
H
H
Hayashi
T
T
Shinbara
M
M
Yamasaki
M
M
Utsumi
M
M
D000941:Antigens / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003296:Cooking; D003876:Dermatitis, Atopic / Q000097:blood* / Q000276:immunology*; D004527:Egg Proteins / Q000009:adverse effects / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology*; D006358:Hot Temperature; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000276:immunology*; D008894:Milk Proteins / Q000009:adverse effects / Q000276:immunology*; D011489:Protein Denaturation; D011852:Radioallergosorbent Test
D000941:Antigens; D004527:Egg Proteins; D008894:Milk Proteins