Relation of phenotype evolution of HIV-1 to envelope V2 configuration.
Biological variability of human immunodeficiency virus type-1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated CD4+ T cell loss and rapid progression to AIDS. The V1 to V2 and V3 region of the viral envelope glycoprotein gp120 contained the major determinants of SI capacity. The configuration of a hypervariable locus in the V2 domain appeared to be predictive for non-SI to SI phenotype conversion. Early prediction of HIV-1 phenotype evolution may be useful for clinical monitoring and treatment of asymptomatic infection.
Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
M
M
Groenink
R A
RA
Fouchier
S
S
Broersen
C H
CH
Baker
M
M
Koot
A B
AB
van't Wout
H G
HG
Huisman
F
F
Miedema
M
M
Tersmette
H
H
Schuitemaker
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D016384:Consensus Sequence; D014644:Genetic Variation; D015726:Giant Cells / Q000382:microbiology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D006679:HIV Seropositivity / Q000382:microbiology; D015497:HIV-1 / Q000737:chemistry* / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010641:Phenotype; D011487:Protein Conformation; D011995:Recombination, Genetic
D015699:HIV Envelope Protein gp120