125I embedded in an orbital prosthesis for retreatment of recurrent retinoblastoma.
The application of radiation therapy in the retreatment of unilateral recurrent retinoblastoma presents a very difficult dilemma in which consideration must be given to preservation of vision in the remaining eye while tumoricidal doses of irradiation are delivered. A technique is described in which a methylmetraculate eye sphere carrying a single Iodine-125 seed was used to deliver local irradiation to the orbital tissues in a patient with multiple episodes of recurrent retinoblastoma. The tissue dose at 2 mm depth was 2630 cGy while the dose to the retina of the remaining eye and to the optic chiasm was negligible.
Bentel
G C
GC
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710.
Halperin
E C
EC
Buckley
E G
EG
D001918:Brachytherapy / Q000379:methods*; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D005137:Eye, Artificial; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D011879:Radiotherapy Dosage; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery
D007457:Iodine Radioisotopes