T-Lymphocytes bearing the gamma delta T-cell receptor in cutaneous lesions of Langerhans' cell histiocytosis.
The aim of this study was to investigate the regional importance of gamma delta T cells in cutaneous lesions of Langerhans' cell histiocytosis. Six cases of Langerhans' cell histiocytosis were investigated by immunohistochemical techniques (alkaline phosphatase-antialkaline phosphatase complex and indirect immunoperoxidase). Increase of gamma delta T cells was observed in 3 cases of Langerhans' cell histiocytosis. In these cases up to 30% of CD3+ cells stained with an anti-TCR gamma delta monoclonal antibodies and in two of them gamma delta T cells showed a marked epidermotropism. In the specimens of the remaining three cases gamma delta T cells were found in an overall percentage of 5% of CD3+ cells, but in two cases a significant increase of epidermal gamma delta T cells was observed. The finding of numerous gamma delta T cells in Langerhans' cell histiocytosis is provocative and supports the suggestion of a functional relationship between gamma delta T cells and LCH cells.
Unit of Dermatology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
M
M
Alaibac
A C
AC
Chu
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012871:Skin Diseases / Q000473:pathology*; D013601:T-Lymphocytes / Q000648:ultrastructure*
D000911:Antibodies, Monoclonal; D016692:Receptors, Antigen, T-Cell, gamma-delta