Somatic mutation and memory.
The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
Deutsches RheumaForschungsZentrum, Berlin, Germany.
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Berek
D000818:Animals; D000916:Antibody Diversity / Q000235:genetics; D000917:Antibody Formation; D001323:Autoantibodies / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007114:Immunization; D007156:Immunologic Memory / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000276:immunology; D008221:Lymphoid Tissue / Q000166:cytology; D008224:Lymphoma, Follicular / Q000235:genetics / Q000276:immunology; D051379:Mice; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology
D001323:Autoantibodies; D009363:Neoplasm Proteins