Effect of age on susceptibility of carcinogen benzidine-hydrochloride.
Susceptibility of carcinogen (benzidine hydrochloride) was checked by degranulation technique in rats of three different (young, adult and old) age groups. The dose response curves of these three different groups showed different per cent degranulation. Comparative data of dose response of benzidine hydrochloride observed on the basis of RNA/Protein ratio basis showed that old animals were more susceptible to carcinogens than young and adult animals.
Department of Biochemistry, Panjab University, Chandigarh, India.
S K
SK
Bhardwaj
S K
SK
Jagota
D000375:Aging; D000818:Animals; D001560:Benzidines / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity; D015550:Cell Degranulation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects*; D051381:Rats
D001560:Benzidines; D002273:Carcinogens; C029876:benzidine