[Activity of lysosomal enzymes in diabetes mellitus patients along with diffuse enlargement of the thyroid gland].
Activity of lysosomal enzymes was studied in 68 patients with Types 1 and 2 diabetes mellitus concurrent with diffuse thyroid enlargement. A decrease in activities of beta-galactosidase and DNAase and activation of cathepsins were detected in the leukocytes fraction from patients with Types 1 or 2 diabetes mellitus, thus demonstrating that metabolic impairments occurred in diabetes mellitus. These patterns were improved after intensive insulin therapy. Hyperfunction of the thyroid gland in patients with moderate Type 1 diabetes mellitus normalizes the activity of lysosomal enzymes.
E A
EA
Stroev
L G
LG
Chugunova
I I
II
Dubinina
D000293:Adolescent; D000328:Adult; D000368:Aged; D002403:Cathepsins / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000201:enzymology*; D004789:Enzyme Activation; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology*; D001616:beta-Galactosidase / Q000378:metabolism
D003851:Deoxyribonucleases; D001616:beta-Galactosidase; D002403:Cathepsins
Aktivnost' lizosomnykh fermentov u bol'nykh sakharnym diabetom pri sochi s diffuznym uvelicheniem shchitovidnoĭ zhelezy.