Mapping of the human spermidine synthase gene (SRM) to 1p36 and a probable pseudogene (SRML2) to region 3p14-->q21.
Using Southern blot analysis of panels of human podent somatic cell hybrids and chromosomal in situ hybridization, we have been able to assign human spermidine synthase DNA sequences to 1p36 (SRM) and 3p14-->q21 (SRML2). Present data suggest that the former chromosomal site harbors the functional gene and the latter site only a pseudogene.
Department of Medical Genetics, Oulu University Central Hospital, Finland.
R
R
Winqvist
L
L
Alhonen
K H
KH
Grzeschik
J
J
Jänne
T O
TO
Eloranta
D001345:Autoradiography; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011436:Spermidine Synthase / Q000235:genetics*
D011436:Spermidine Synthase