Systemic histiocytosis presenting as multiple sclerosis.
A patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non-Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.
Smith
M E
ME
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892.
Katz
D A
DA
Harris
J O
JO
Frank
J A
JA
Kufta
C V
CV
McFarlin
D E
DE
D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006644:Histiocytes / Q000473:pathology; D015614:Histiocytosis / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D011859:Radiography; D011877:Radionuclide Imaging
D005904:Glial Fibrillary Acidic Protein