[The treatment of metastasized kidney cancer. Current data and perspectives].
Metastatic renal cancer has a poor prognosis because of the limited impact of traditional treatment modalities on this tumour. The few long-term survivals obtained after isolated surgical resection of the primary tumour or its metastases can be attributed to the occasionally unpredictable natural history of this tumour and isolated surgical resection generally does not appear to improve the survival of these patients. Among non-surgical treatments, radiotherapy is purely palliative and hormone therapy has been shown to be ineffective. New therapeutic approaches have been recently developed, suggesting a possible improvement in the prognosis of metastatic renal cancer. A better understanding of the mechanisms of chemoresistance of renal cancer should lead, in the near future, to the use of drugs capable of increasing the efficacy of cytotoxic chemotherapy in this tumour. The results obtained with new forms of immunotherapy open up prospects for combined immunosurgical modalities.
Service d'Urologie, Hôpital Saint-Louis, Paris.
F
F
Desgrandchamps
O
O
Cussenot
J M
JM
Maréchal
A
A
Cortesse
P
P
Teillac
A
A
Le Duc
D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000628:therapy; D009362:Neoplasm Metastasis / Q000473:pathology
Les traitements du cancer du rein métastasé. Données actuelles et perspectives.