(+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor.
SmithKline Beecham Pharmaceuticals, Department of Medicinal Chemistry, Harlow, Essex, U.K.
F D
FD
King
A M
AM
Brown
L M
LM
Gaster
A J
AJ
Kaumann
A D
AD
Medhurst
S G
SG
Parker
A A
AA
Parsons
T L
TL
Patch
P
P
Raval
D000818:Animals; D001921:Brain / Q000378:metabolism; D002227:Carbazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D004285:Dogs; D066298:In Vitro Techniques; D008968:Molecular Conformation; D011817:Rabbits; D051381:Rats; D011985:Receptors, Serotonin / Q000145:classification / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects
D002227:Carbazoles; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C081764:3-amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole