Simple sequence repeat polymorphism within the p53 gene.
This report describes a new polymorphism, in intron 3 of the p53 gene, which consists of a single repeat of 16 nucleotides, absent in the published wild-type p53 gene sequence. In the Caucasian population tested (n = 82), 28% of individuals were heterozygotes for this polymorphism. Using PCR-based analysis, we were able to demonstrate p53 allelic losses in three of six breast tumors from heterozygote patients tested.
Laboratoire d'Immunologie Moléculaire, Institut Gustave Roussy, Villejuif, France.
V
V
Lazar
F
F
Hazard
F
F
Bertin
N
N
Janin
D
D
Bellet
B
B
Bressac
D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics; D005091:Exons; D005260:Female; D016158:Genes, p53; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D044465:White People / Q000235:genetics
D009838:Oligodeoxyribonucleotides