Congenital anomalies and genetic syndromes in 173 cases of medulloblastoma.
One hundred seventy-three consecutive cases of medulloblastoma recorded in the Manchester Children's Tumour Registry from 1954 to 1989 were studied. After review of case notes, X-rays, and health surveys the clinical outcome and incidence of congenital anomaly was determined. A previously unreported association with Rubinstein Taybi syndrome was found. Evidence of a genetic syndrome or congenital anomaly was found in 6.4%. These figures provide further evidence of the higher-than-expected incidence of congenital abnormalities.
Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, England.
G
G
Evans
L
L
Burnell
R
R
Campbell
H R
HR
Gattamaneni
J
J
Birch
D000293:Adolescent; D002528:Cerebellar Neoplasms / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000235:genetics; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000150:complications*; D012042:Registries; D013577:Syndrome