Studies on placental transfer of celiprolol.
The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers in the child. Therefore, in further investigations only the racemate needs to be determined.
Kofahl
B
B
Department of Pharmacology, University of Frankfurt/Main, Germany.
Henke
D
D
Hettenbach
A
A
Mutschler
E
E
D017272:Celiprolol / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D013237:Stereoisomerism
D017272:Celiprolol