Enhancement of resistance to bacterial infection in mice by vitamin B2.
We found that the intramuscular injection of vitamin B2 enhanced host resistance to E. coli infection in a dose-dependent manner (6.25 mg/kg-100 mg/kg). Furthermore, VB2 exhibited the protective activity against Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Actinobacillus pleuropneumoniae. The mechanism of action of VB2 for enhancing resistance in mice may be, at least in part, its ability to stimulate the multiplication of neutrophils and monocytes, and to activate macrophages.
Research and Development Division, Eisai Co., Ltd., Ibaraki, Japan.
S
S
Araki
M
M
Suzuki
M
M
Fujimoto
M
M
Kimura
D000189:Actinobacillus Infections / Q000276:immunology / Q000517:prevention & control; D016977:Actinobacillus pleuropneumoniae; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D007113:Immunity, Innate; D007273:Injections, Intramuscular; D007710:Klebsiella Infections / Q000276:immunology / Q000517:prevention & control; D007711:Klebsiella pneumoniae; D007958:Leukocyte Count; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D010587:Phagocytosis; D011552:Pseudomonas Infections / Q000276:immunology / Q000517:prevention & control; D011550:Pseudomonas aeruginosa; D012256:Riboflavin / Q000008:administration & dosage / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000276:immunology / Q000517:prevention & control; D013211:Staphylococcus aureus
D012256:Riboflavin