Bone scans in neuroblastoma.
Eighty-Six patients of neuroblastoma ranging in age from four months to 15 years were studied with 99m Tc-MDP for total skeletal survey over a period of seven years (1983-1990). The diagnosis of neuroblastoma was based on bone marrow examination, FNAC, lymph node biopsy, histopathology. Bone imaging was performed three hrs. after intravenous administration of 99m Tc-MDP. Out of 86 patients, 45 patients had positive bone scan showing osseous concentration in 122 sites and extraosseous concentration in 34 sites. Seven patients had liver metastases. None of these liver metastases showed concentration of MDP. Fourteen patients underwent surgery for the primary tumour at the time of bone scanning. Ten patients were studied at the time of follow up, of which four patients showed good response as bony metastases were not demonstrated on bone scintigraphy and X-rays. In conclusion, bone scan is an useful test in neuroblastoma in delineating the bony metastases and also in assessing the efficacy of chemotherapy in these patients.
Bhogate
B M
BM
Radiation Medicine Centre, B.A.R.C., Parel, Bombay, India.
Samuel
A M
AM
Ramanathan
P
P
D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000473:pathology; D000293:Adolescent; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013669:Technetium Tc 99m Medronate; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000473:pathology
D013669:Technetium Tc 99m Medronate