Tissue penetration of clindamycin in diabetic foot infections.
Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving clindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0.04-2.8 mg/kg in tissues and 1.1-11.1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0.13.
Duckworth
C
C
Department of Medicine, Medical College of Georgia, Augusta 30912.
Fisher
J F
JF
Carter
S A
SA
Newman
C L
CL
Cogburn
C
C
Nesbit
R R
RR
Wray
C H
CH
D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism; D002981:Clindamycin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D005534:Foot Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D014018:Tissue Distribution
D002981:Clindamycin