[Changes in endocochlear potential induced by potassium-channel blockers].
The effect of various potassium-channel blockers, 4-aminopyridine (4-AP), tetraethylammonium (TEA) and quinine, on the endocochlear potential (EP) was studied in perfused guinea pig inner ears. The fast K(+)-channel blocker, 4-AP, did not alter EP but changed its response model to intense noise exposure. While TEA and quinine significantly reduced the amplitude of negative component of EP (N-EP), comparing with a relatively smaller increase in general EP (G-EP). The results indicated the existence of different K(+)-channels with different physiological functions.
Department of Physiology, Nanjing Railway Medical College.
J
J
Wang
Q H
QH
Li
W J
WJ
Dong
J S
JS
Chen
D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D015221:Potassium Channels / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D015221:Potassium Channels; D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D011803:Quinine; D015761:4-Aminopyridine