A70104 and food intake in pigs: implication for the CCK 'satiety' hypothesis.
The aim of the present study was to determine whether CCK released from the small intestine during a meal acts as a satiety factor. The effects of the novel CCKA antagonist A70104 (50-200 micrograms kg-1, i.v.) were investigated on operant food intake in 4 h food-deprived pigs. None of the doses used had any significant effects on the amount of food consumed by the animals over the 2 h measurement period. However, pretreatment of the pigs with A70104 (100 micrograms kg-1) did block the inhibitory effect of exogenous CCK (1 microgram kg-1, i.v.) on operant feeding. These results thus question the validity of the hypothesis that endogenous peripheral CCK acts as a satiety factor.
Ebenezer
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IS
AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK.
Parrott
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RF
D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012054:Reinforcement, Psychology; D012528:Satiety Response / Q000187:drug effects*; D013552:Swine
D011804:Quinolines; D011949:Receptors, Cholecystokinin; C063047:A 65186; D002766:Cholecystokinin