Aberrations of chromosome segment 12q13-15 characterize a subgroup of hemangiopericytomas.
BACKGROUND
In later years, several characteristic acquired chromosomal aberrations have been identified in mesenchymal tumors. Many of these aberrations, either alone or with histopathologic and clinical data, are useful in diagnosis. The cytogenetic profile of hemangiopericytomas has been poorly investigated.


METHODS
Short-term cultures from four spindle cell tumors were cytogenetically analyzed.


RESULTS
Clonal acquired chromosome aberrations were found in three of the four tumors: inv(12) (q14q24) in a malignant hemangiopericytoma, a supernumerary der(3)t(3;12) (p21-23;q13-15) in a benign hemangiopericytoma, and t(6;12;19) (p21;q13;p13) in a spindle cell sarcoma that was histologically a malignant hemangiopericytoma or a synovial sarcoma. The fourth tumor, a malignant hemangiopericytoma, had a normal karyotype. The tumors with inv(12) and t(6;12;19) had subclones with trisomy 5 in addition to the structural changes.


CONCLUSIONS
The current findings and the literature data indicate that a subgroup of hemangiopericytomas is characterized by rearrangement of chromosome segment 12q13-15.
Mandahl
N
N
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Orndal
C
C
Heim
S
S
Willén
H
H
Rydholm
A
A
Bauer
H C
HC
Mitelman
F
F
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000235:genetics / Q000473:pathology