Effect of nootropic Solcoseryl on kainic acid-induced excitotoxic brain injury.
Solcoseryl (S) has been shown to provide significant cytoprotection in a variety of models of cerebral hypoxia. In the present study, we quantified the epileptiform effects caused by kainic acid administered into the pontine reticular formation of rats and their response to S pretreatment. Compared to saline, the agent appeared to significantly reduce the mortality of rats in the course of status epilepticus. However, S-pretreated rats manifested an increased incidence of behavioral seizures. This untoward effect is attributed to the fact that S improves the functional potential of injured tissue and retards the period of metabolic exhaustion at a time when neuronal activity should be minimized.
Mintz
M
M
Department of Psychology, Tel-Aviv University, Ramat-Aviv, Israel.
Knowlton
B
B
Myslobodsky
M S
MS
D000183:Actihaemyl / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011149:Pons / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012154:Reticular Formation / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced / Q000523:psychology
D011619:Psychotropic Drugs; D000183:Actihaemyl; D005947:Glucose; D007608:Kainic Acid