Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10.
Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3' untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.
Kamat
A K
AK
Department of Biochemistry and Molecular Biology, Lederle Graduate Research Center, University of Massachusetts, Amherst.
Rocchi
M
M
Smith
D I
DI
Miller
O J
OJ
D000818:Animals; D016466:CHO Cells; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D034904:Lamin Type A; D034882:Lamins; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics*
D034904:Lamin Type A; D034882:Lamins; D009687:Nuclear Proteins