Ki-1-positive anaplastic large cell lymphoma initially diagnosed as Hodgkin's disease by fine needle aspiration (FNA) cytology.
A 45-year-old male presented with a large mass in the left axilla. FNA cytology was interpreted as Hodgkin's disease (HD), lymphocyte depletion (LD) type, but histopathologic and immunohistochemical examination showed features of Ki-1-positive anaplastic large cell lymphoma. Unrepresentative sampling by the FNA from the tumour periphery resulted in a false impression of dual reactive and neoplastic cell populations, which together with the frequent Reed-Sternberg-like cells led to the initial erroneous impression of HD. Therefore, the cytologic diagnosis of HD, LD should be approached with caution.
Unit of Histopathology, Farwaniya Hospital, Kuwait.
I A
IA
Aljajeh
D K
DK
Das
D
D
Krajci
D015703:Antigens, CD / Q000032:analysis; D001707:Biopsy, Needle; D003951:Diagnostic Errors; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D016539:Reed-Sternberg Cells / Q000473:pathology
D015703:Antigens, CD