Dendritic development in the dorsal lateral geniculate nucleus of ferrets in the postnatal absence of retinal input: a Golgi study.
In order to determine the ongoing role of retinal fibers in the development of dorsal lateral geniculate nucleus (dLGN) neurons during postnatal development, the development of dLGN neurons in the postnatal absence of retinal input was studied in pigmented ferrets using the Golgi-Hortega technique. The development of four dLGN cell classes, defined on the basis of somatic and dendritic morphology, was described previously in normal ferrets (Sutton and Brunso-Bechtold, 1991, J. Comp. Neurol. 309:71-85). The present results indicate that the morphological development of dLGN neurons is strikingly similar in normal and experimental ferrets. The exuberant dendritic appendages that appear after eye opening in normal ferrets are overproduced and eliminated in the postnatal absence of retinal input; however, the final reduction of these transient appendages is delayed. Because exuberant appendages develop in the absence of retinal input, their production cannot depend upon visual experience. Differences in cell body size between normal and experimental ferrets are apparent only after neurons can be classified at the end of the first postnatal month. Cell body size is markedly reduced for class 1 neurons; class 2 cells also are reduced in size but to a far lesser extent. As there is a general trend for class 1 neurons to have the functional properties of Y-cells, it is likely that the dLGN neurons most affected by the absence of retinal input also are Y-cells.
Sutton
J K
JK
Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1010.
Brunso-Bechtold
J K
JK
D000818:Animals; D001369:Axons / Q000502:physiology; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D015353:Eye Enucleation; D005260:Female; D005289:Ferrets; D005829:Geniculate Bodies / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D006651:Histocytochemistry; D009411:Nerve Endings / Q000502:physiology; D011247:Pregnancy; D012160:Retina / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure; D014795:Visual Pathways / Q000166:cytology / Q000254:growth & development / Q000648:ultrastructure