A molecular variant of angiotensinogen associated with preeclampsia.
Pregnancy-induced hypertension (PIH) is a heterogeneous disorder which complicates 5-7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life-threatening form; a multi-system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy-induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension.
Department of Obstetrics and Gynecology, University of Utah, School of Medicine, Salt Lake City 84132.
K
K
Ward
A
A
Hata
X
X
Jeunemaitre
C
C
Helin
L
L
Nelson
C
C
Namikawa
P F
PF
Farrington
M
M
Ogasawara
K
K
Suzumori
S
S
Tomoda
D000808:Angiotensinogen / Q000235:genetics* / Q000502:physiology; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D005260:Female; D014644:Genetic Variation; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008969:Molecular Sequence Data; D010298:Parity; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000502:physiology*; D044465:White People / Q000235:genetics
D000808:Angiotensinogen