Biogenic amine metabolites in the CSF of patients with late onset and alcoholic ataxias.
The levels of monoamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in lumbar cerebrospinal fluid (CSF) from 10 patients with late onset ataxia, 8 patients with alcoholic ataxia and 18 control patients. The levels did not differ significantly among the three groups of patients suggesting that the central neuronal systems utilizing dopamine, noradrenaline and 5-hydroxytryptamine do not have a significant pathophysiological role in these forms of ataxias. The measurement of CSF amine metabolites probably does not contribute to the differential diagnosis of ataxias.
Kaakkola
S
S
Department of Neurology, University of Helsinki, Finland.
Tuomainen
P
P
Männistö
P T
PT
Palo
J
J
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000503:physiopathology; D001259:Ataxia / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000503:physiopathology; D001679:Biogenic Amines / Q000134:cerebrospinal fluid* / Q000502:physiology; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D013129:Spinal Puncture
D001679:Biogenic Amines; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine