Effect of chloroquine on hepatic heme-oxygenase during Plasmodium berghei infection in mice.
Hepatic heme-oxygenase and heme levels were monitored during Plasmodium berghei infection and chloroquine treatment in Swiss albino mice. A progressive increase in heme-oxygenase and heme levels was noticed with the rise in parasitemia. Further, chloroquine treatment did not result in any change towards normal heme-oxygenase and heme content, when they were assayed a week after cessation of drug treatment. Chloroquine treatment of non-parasitized and parasitized mice resulted in significant loss of the enzyme activity after about 6 weeks.
Department of Biochemistry, Central Drug Research Institute, Lucknow, India.
P
P
Srivastava
S K
SK
Puri
G P
GP
Dutta
V C
VC
Pandey
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D006418:Heme / Q000032:analysis; D006419:Heme Oxygenase (Decyclizing) / Q000032:analysis*; D008099:Liver / Q000201:enzymology*; D008288:Malaria / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D008862:Microsomes, Liver / Q000737:chemistry; D010962:Plasmodium berghei
D006418:Heme; D002738:Chloroquine; D006419:Heme Oxygenase (Decyclizing)