Pulmonary arterial wedge pressure measurement can modify pulmonary haemodynamics in patients with chronic lung disease.
In 20 patients with chronic lung disease in stable condition, haemodynamic values were compared during wedging of a Swan-Ganz catheter, either in a distal branch of the pulmonary artery, or by balloon inflation (with 1 ml) in a proximal branch, mostly excluding right lower lobe perfusion. Average pulmonary arterial wedge pressure, systemic arterial pressure, transcutaneous and mixed venous oxygen saturation, cardiac output and pulmonary blood volume (PBV) were not statistically different during distal and proximal wedging, but systolic pulmonary arterial pressure and pulmonary vascular resistance were slightly higher during balloon inflation (P < 0.05). In four patients, PBV decreased by 20% or more; cardiac output was reduced and mean systemic arterial pressure diminished by 10 mmHg or more in three patients. Of the two patients with the lowest PBV, one did not tolerate the balloon inflation because of dyspnoea, and the other showed dramatically haemodynamic changes. These were more likely to occur when the occlusion lead to the exclusion of a still well perfused area. Our results support optimal matching between ventilation and perfusion in patients with chronic lung disease, although both are inhomogeneous. When pulmonary vascular restriction can be suspected, pressure obtained during catheter wedging by balloon inflation should be interpreted with caution. Monitoring arterial oxygen saturation and systemic arterial pressure before and during the manoeuver could help to diagnose haemodynamic effects of the balloon inflation in a proximal pulmonary artery.
Unité 14 INSERM, Vandoeuvre, France.
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Schrijen
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Serri
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Chabot
D000328:Adult; D000368:Aged; D001795:Blood Pressure Determination / Q000009:adverse effects*; D001810:Blood Volume / Q000502:physiology; D002908:Chronic Disease; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D011651:Pulmonary Artery / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology