[Malignant melanoma of the choroid associated with neurofibromatosis].
A sixteen-year-old white girl with peripheral neurofibromatosis (NF1), who had been treated for a glioma of the optic nerves and chiasma developed a choroidal mass in her only functional eye. After a transchoroïdal biopsy, the pathologic examination disclosed a choroïdal melanoma of epithelioid cell type, using morphological criteria as well as an immunohistochemical study. After treatment with a ruthenium plaque, the tumor completely regressed over 4 months. According to the data of the literature, neurofibromatosis seems to predispose to the development of uveal melanomas.
Bacin
F
F
Service d'Ophtalmologie, C.H.R.U., Hôpital Gabriel Montpied, Clermont-Ferrand.
Kemeny
J L
JL
D'Hermies
F
F
Rozan
R
R
Decroix
P
P
Dalens
H
H
Kalifa
C
C
D000293:Adolescent; D002830:Choroid Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008545:Melanoma / Q000150:complications* / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000150:complications*
Mélanome malin de la choroïde associé à une neurofibromatose.