[Effect of D1 and D2 dopamine receptor antagonists on acupuncture analgesia].
Some highly selective D1 or D2 receptor antagonists were tested on rabbit skin pain model to investigate the effect of the subtypes of dopamine receptor on acupuncture analgesia. It was found that iv. of D2 receptor antagonists haloperidol and clozapine, had a potentiating effect on acupuncture analgesia. Icv. of D2 receptor antagonists domperidone and sulpiride and D1 receptor antagonist SCH23390 also enhanced acupuncture analgesia markedly. The effect of D1 and D2 receptor on acupuncture analgesia was discussed.
Wang
H H
HH
Department of Neurobiology, Shanghai Medical University.
Xu
S F
SF
D015667:Acupuncture Analgesia; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D004294:Domperidone / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D015671:Electroacupuncture; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D017288:Pain Threshold / Q000187:drug effects; D011817:Rabbits; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D013469:Sulpiride / Q000494:pharmacology
D001552:Benzazepines; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D004294:Domperidone; D013469:Sulpiride; D003024:Clozapine; D006220:Haloperidol