Mathematical modeling of T-cell proliferation.
A mathematical model of the T-lymphocyte proliferation process (in vivo and in vitro) is presented. This model takes into account cell-cycle progression and the regulation by lymphokines (lymphocyte activating factor interleukin 1 and T-cell growth factor interleukin 2). Using data on the generalized picture of the short-term course of viral hepatitis B, the parameter estimation procedure is carried out. The possibility of immunocorrection (by means of injection of a pharmacologic dose of IL-2) during the immune response to viral hepatitis B with T-lymphocyte deficiency is shown.
Institute of Biochemistry and Physiology of Microorganisms, Pushino, Russia.
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Sidorov
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Romanyukha
D000818:Animals; D002453:Cell Cycle; D006801:Humans; D008213:Lymphocyte Activation; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology