[Cardiorespiratory evaluation of midazolam and thiopental during their use in patients undergoing translumbar aortography in decubitus prone position and ASA IV].
OBJECTIVE
To verify the cardiorespiratory effects of midazolam and thiopental in ASA IV patients undergoing translumbar aortography in the decubitus prone position.


METHODS
A prospective double blind study was carried out on 26 patients (mean age, 65.9 yr) allocated randomly to receive either midazolam (0.13 mg/kg) or thiopental (4 mg/kg) i.v. Without being premedicated all the patients had fentanyl 1.5 micrograms/kg i.v. and were preoxygenated with 50% oxygen before induction of anaesthesia. Blood pressure was measured by oscilometry and blood oxygenation by pulseoxymetry.


RESULTS
No significant differences were found in the hemodynamic values (blood pressure, heart rate, double product) upon comparison of the two groups. Apnea was more frequent in the thiopental group 61.5% (8 out of 13 patients) than in the midazolam group 15.3% (2 out of 13 patients). Hypoxemia appeared only in the former group (61.5% of the cases).


CONCLUSIONS
In patients undergoing translumbar aortography midazolam and thiopental behaved similarly with regard to hemodynamics. Midazolam produced less apnea than thiopental.
Hospital Clínico de Valladolid, Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad de Valladolid.
E
E
Tamayo
A
A
Llorente
R
R
Muñoz
F J
FJ
Alvarez
D000368:Aged; D000369:Aged, 80 and over; D001027:Aortography / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008161:Lumbosacral Region; D008297:Male; D008874:Midazolam / Q000009:adverse effects / Q000494:pharmacology*; D008875:Middle Aged; D011187:Posture; D011446:Prospective Studies; D012123:Pulmonary Ventilation / Q000187:drug effects*; D012720:Severity of Illness Index; D013874:Thiopental / Q000009:adverse effects / Q000494:pharmacology*
D013874:Thiopental; D008874:Midazolam
Evaluación cardiorrespiratoria del midazolam y tiopental durante su empleo en la aortografía translumbar, y en pacientes en decúbito prono y ASA IV.