Decreased glucose-induced thermogenesis at the onset of obesity.
To investigate the possible existence of a defect of thermogenesis at the onset of obesity, we studied glucose-induced thermogenesis (GIT) during an oral glucose-tolerance test (OGTT) (1 g/kg body wt) in 12 women who were at the onset of obesity (group A) compared with 12 long-standing obese women (group B) and 8 lean control subjects. During OGTT hyperinsulinemia and glucose intolerance were measured in group B, suggesting an insulin-resistant state, but not in group A. A similar defect in GIT occurred in both obese groups (8.9 +/- 1.5% in control subjects vs 4.2 +/- 1.1% in group A and 4.3 +/- 1.0% in group B, P < 0.05) despite the absence of alteration in nonoxidative glucose metabolism. We conclude that a decrease in GIT already exists at the onset of obesity, which supports the hypothesis of a possible involvement of this defect in the genesis of obesity.
Laville
M
M
Institut National de la Santé et de la Recherche Médicale, Faculté de médecine Alexis Carrel, Lyon, France.
Cornu
C
C
Normand
S
S
Mithieux
G
G
Beylot
M
M
Riou
J P
JP
D000042:Absorption / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D001833:Body Temperature Regulation / Q000187:drug effects*; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D010084:Oxidation-Reduction / Q000187:drug effects
D005947:Glucose