Surgical risk in alcoholic cirrhotic postmenopausal women: prognostic value of levels of hormones.
Because increased prolactin levels and hyperprolactinemia in the presence of encephalopathy in males with cirrhosis (alcohol-induced cirrhosis in particular) are associated with statistically increased mortality, we have examined pre-surgical levels of prolactin and other hormones, as well as the presence of encephalopathy, in 12 postmenopausal women with end-stage alcohol-induced cirrhosis in relation to liver transplant survival. Levels of estradiol were significantly lower, while luteinizing hormone (LH) and 17-hydroxyprogesterone as well as the ratio of estradiol to testosterone were significantly higher prior to transplantation among the women who survived, compared with non-survivors. A similar pattern was seen for transplant candidates who died before transplantation as compared with still-living candidates. These findings suggest that pre-operative levels of sex steroids and pituitary hormones may have prognostic value in alcoholic cirrhotic postmenopausal women undergoing liver transplantation.
Gavaler
J S
JS
Department of Medicine, School of Medicine, University of Pittsburgh, Pennsylvania.
Van Thiel
D H
DH
Deal
S R
SR
D019326:17-alpha-Hydroxyprogesterone; D004958:Estradiol / Q000032:analysis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D012739:Gonadal Steroid Hormones / Q000032:analysis*; D006501:Hepatic Encephalopathy / Q000503:physiopathology; D006801:Humans; D006908:Hydroxyprogesterones / Q000032:analysis; D006966:Hyperprolactinemia / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation; D007986:Luteinizing Hormone / Q000032:analysis; D008593:Menopause; D008875:Middle Aged; D010907:Pituitary Hormones / Q000032:analysis*; D011379:Prognosis; D011388:Prolactin / Q000032:analysis; D012307:Risk Factors; D015996:Survival Rate; D013739:Testosterone / Q000032:analysis
D012739:Gonadal Steroid Hormones; D006908:Hydroxyprogesterones; D010907:Pituitary Hormones; D013739:Testosterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone