Multipoint linkage analysis in X-linked juvenile retinoschisis.
Thirteen families with X-linked juvenile retinoschisis (XLRS) were studied in order to evaluate the linkage relationship between the XLRS locus (RS) and seven X-chromosomal DNA markers. Linkage was found between RS and DXS9 (theta max = 0.11, Zmax = 4.17), DXS16 (theta max = 0.06, Zmax = 7.72), DXS41 (theta max = 0.06, Zmax = 8.13) and DXS43 (theta max = 0.03, Zmax = 6.11). Recombinants were found between RS and all loci studied. Multipoint linkage analysis and recombination analysis significantly favour the order of Xpter-(DXS9, (DXS16-DXS43))-RS-DXS41-Xcen.
Netherlands Ophthalmic Research Institute, Amsterdam.
A A
AA
Bergen
M J
MJ
van Schooneveld
U
U
Orth
E M
EM
Bleeker-Wagemakers
A
A
Gal
D000328:Adult; D015139:Blotting, Southern; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D012162:Retinal Degeneration / Q000235:genetics*; D014960:X Chromosome
D005819:Genetic Markers; D004247:DNA