The relative effects of selective M1 muscarinic antagonists on rapid eye movement sleep.
Three muscarinic antagonists, scopolamine, trihexyphenidyl and biperiden were systemically administered (0, 0.5, 1, 2 and 4 mg/kg) in rats. Scopolamine increased wakefulness and deceased sleep, both slow wave and REM. Trihexyphenidyl increased wakefulness and decreased REM sleep while biperiden decreased REM sleep selectively. The rank order REM-suppressing effect was roughly scopolamine and trihexyphenidyl having a greater suppressing effect than biperiden. These results suggest that the regulation of the sleep-wake cycle is at least partially controlled by the M1 muscarinic receptor.
Zoltoski
R K
RK
Department of Psychiatry, Veterans Administration Medical Center, La Jolla, CA 92093.
Velazquez-Moctezuma
J
J
Shiromani
P J
PJ
Gillin
J C
JC
D000818:Animals; D001712:Biperiden / Q000494:pharmacology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D008297:Male; D018727:Muscarinic Antagonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000494:pharmacology; D012895:Sleep, REM / Q000187:drug effects*; D014282:Trihexyphenidyl / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects
D018727:Muscarinic Antagonists; D001712:Biperiden; D014282:Trihexyphenidyl; D012601:Scopolamine