Applications of lipid-coated microbubble ultrasonic contrast to tumor therapy.
Lipid-coated microbubbles (LCM) make an excellent diagnostic ultrasonic contrast agent in experimental tumor systems. LCM have been shown to aggregate in brain tumors and subcutaneous tumors after intravenous administration, and to provide persistent image enhancement for many minutes. In this work, experimental subcutaneous Walker Carcinosarcoma is insonated after the bubbles are given intravenously. Selective necrosis, lymphocyte proliferation and hemorrhage within the tumor can be demonstrated. Preliminary data are given to demonstrate this phenomenon. The mechanism of the effect is discussed in the context of both heating and cavitation.
University of Connecticut Health Center, Department of Surgery, Farmington 06030-3955.
R H
RH
Simon
S Y
SY
Ho
S C
SC
Lange
D F
DF
Uphoff
J S
JS
D'Arrigo
D000818:Animals; D002279:Carcinoma 256, Walker / Q000473:pathology / Q000628:therapy*; D003287:Contrast Media; D006470:Hemorrhage / Q000473:pathology; D008055:Lipids; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008863:Microspheres; D009336:Necrosis / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D014464:Ultrasonic Therapy / Q000379:methods*
D003287:Contrast Media; D008055:Lipids