High-frequency monitoring for early detection of cisplatin ototoxicity.
Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (> or = 8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing.
Fausti
S A
SA
Department of Veterans Affairs, Portland Veterans Affairs Medical Center, OR 97207.
Henry
J A
JA
Schaffer
H I
HI
Olson
D J
DJ
Frey
R H
RH
Bagby
G C
GC
D000465:Algorithms; D001301:Audiometry, Pure-Tone / Q000295:instrumentation / Q000379:methods; D001309:Auditory Threshold; D002138:Calibration; D002945:Cisplatin / Q000009:adverse effects*; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods; D006316:Hearing Loss, High-Frequency / Q000139:chemically induced* / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002945:Cisplatin