Effects of ciprofloxacin on chromosomes, and hepatic and renal functions in rats.
In the present study, ciprofloxacin, a fluoroquinolone antibiotic, was evaluated in vivo. The toxic effects of ciprofloxacin (20 and 200 mg/kg/day) on kidney and liver functions, and on chromosomes were investigated in rats. 20 mg/kg/day ciprofloxacin did not significantly affect urine composition, serum enzyme levels and the haematocrit, affecting only creatinine clearance. The 200 mg/kg/day dose increased urine volume, serum creatinine and and creatinine clearance. Ciprofloxacin at both doses had no significant numerical effect on chromosomes, but there was a statistically significant dose-dependent increase in chromatid-type breakage. Significant histological changes in the liver and kidney were not observed.
Başaran
A
A
Department of Human Biology, Anadolu University, Medical Faculty, Eskişehir, Turkey.
Erol
K
K
Başaran
N
N
Güneş
H V
HV
Açikalin
E
E
Timuralp
G
G
Değirmenci
I
I
Cakmak
E A
EA
Tomatir
A G
AG
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002875:Chromosomes / Q000187:drug effects*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D008297:Male; D051381:Rats; D014556:Urine / Q000737:chemistry
D002939:Ciprofloxacin; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase