Cellular immunity in interstitial nephropathy.
Inflammatory tubulointerstitial nephritis (TIN), either as a primary or as a secondary event, plays an essential role in the development of all forms of chronic renal failure. Experimental models of TIN should help in understanding TIN in humans. As in experimental glomerulopathies, the target antigen can be a kidney structural antigen, from the tubular basement membrane (TBM) or not, or a foreign antigen. While some models are due to deposits of free antibodies or circulating immune complexes, many others involve cell-mediated immunity. This last aspect explains the importance and the originality of experimental TIN.
Department of Nephrology, Hôpital Broussais, Paris, France.
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Meeus
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Rossert
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Druet
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D007111:Immunity, Cellular; D007676:Kidney Failure, Chronic / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology; D007684:Kidney Tubules / Q000276:immunology; D051379:Mice; D009395:Nephritis, Interstitial / Q000276:immunology*; D011817:Rabbits; D051381:Rats