Germline mutations of the p53 tumor-suppressor gene in cancer-prone families: a review.
Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder that predisposes individuals to multiple forms of cancer including breast carcinoma, soft tissue sarcoma, osteosarcoma, leukemia and adrenocortical carcinoma. These diverse tumor types develop at unusually early ages. Analysis of the tumor suppressor gene p53 in family members with LFS have demonstrated that germline mutations in the p53 gene were present in most of the LFS family tested so far. Furthermore, germline p53 mutations were also found in cancer-prone individuals which were not indicative of the LFS.
Unité de Génétique Moléculaire, Institut de Génétique Moléculaire, Unité INSERM 301, Paris, France.
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Soussi
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Leblanc
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Baruchel
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Schaison
D016158:Genes, p53; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics*; D009154:Mutation; D010375:Pedigree