Human chromosome 21: genome mapping and exploration, circa 1993.
Chromosome 21 is the smallest human chromosome, but one of considerable medical importance. A comprehensive physical map of overlapping YACs, a dense linkage map and an almost complete long-range restriction map have been produced much earlier than expected. These mapping accomplishments will greatly facilitate the exploration of chromosome 21, helping to characterize both genes and their impact in health and disease.
Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3914.
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Antonarakis
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male