Differential binding of tioconazole enantiomers to hydroxypropyl-beta-cyclodextrin studied by capillary electrophoresis.
Capillary electrophoresis has been used to determine binding constants of tioconazole enantiomers with hydroxypropyl-beta-cyclodextrin (HP-beta-CD), after correcting for changes in mobility with increasing viscosity. The predicted and observed values of enantiomeric mobility difference were found to be maximum at a concentration of HP-beta-CD equal to the reciprocal of the average binding constant.
Penn
S G
SG
Department of Chemistry, University of York, UK.
Goodall
D M
DM
Loran
J S
JS
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000935:Antifungal Agents / Q000378:metabolism*; D002240:Carbohydrate Sequence; D003505:Cyclodextrins / Q000378:metabolism*; D004586:Electrophoresis / Q000379:methods*; D007093:Imidazoles / Q000378:metabolism*; D008969:Molecular Sequence Data; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
D000935:Antifungal Agents; D003505:Cyclodextrins; D007093:Imidazoles; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C020527:tioconazole