The release of chlorhexidine from modified dental acrylic resin.
A method for the incorporation of chlorhexidine into acrylic resin using monomer together with the pattern of release of chlorhexidine from treated resin into water at 37 degrees C is described. Release from polished and unpolished resin, and from acrylic prepared by short-curing and dry-curing processes are investigated. The pattern of release in all cases was of an exponential nature, showing a rapid release within the first 10 days becoming almost constant at a level of 0.4-1.5 micrograms cm-2 at about 20 days. Release was still evident at the end of the test period in all cases. Release of chlorhexidine into water from the short-cure specimens was accompanied by release of monomer, evident from the odour of the test solutions, indicating that polymerization was not complete.
Biomaterials Research Laboratory, Dental School, University of Birmingham, U.K.
S J
SJ
Wilson
H J
HJ
Wilson
D000180:Acrylic Resins / Q000737:chemistry*; D002710:Chlorhexidine / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D000432:Methanol / Q000737:chemistry; D008768:Methylmethacrylates / Q000737:chemistry; D013499:Surface Properties
D000180:Acrylic Resins; D008768:Methylmethacrylates; D002710:Chlorhexidine; D000432:Methanol