Outcome after allogeneic bone marrow transplant for leukemia in older adults.
OBJECTIVE
To determine whether age over 40 years is associated with adverse outcome after allogeneic bone marrow transplantation for leukemia.


METHODS
A retrospective analysis of outcome after bone marrow transplants for leukemia reported to the International Bone Marrow Transplant Registry (IBMTR) among recipients 30 through 39 years, 40 through 44 years, 45 through 49 years, and 50 years of age and older.


METHODS
Transplantations performed in 138 institutions worldwide and reported to the IBMTR.


METHODS
A total of 2180 recipients of HLA-identical sibling bone marrow transplants for leukemia, divided into four cohorts based on age: 30 through 39 years (n = 1282), 40 through 44 years (n = 527), 45 through 49 years (n = 291), and 50 years and older (n = 80).


RESULTS
Incidence of leukemia-free survival, graft-vs-host disease, and relapse was comparable among the four age cohorts. Patients with advanced leukemia aged 45 years or older had a slightly higher risk of treatment-related mortality, and the 45- through 49-year-old cohort had a higher risk of interstitial pneumonia.


CONCLUSIONS
These data indicate that among leukemia patients over 30 years of age at the time of allogeneic bone marrow transplantation, increasing age into the fifth decade does not adversely affect outcome after transplants from HLA-identical siblings.
Huddinge Hospital, Sweden.
O
O
Ringdén
M M
MM
Horowitz
R P
RP
Gale
J C
JC
Biggs
J
J
Gajewski
A A
AA
Rimm
B
B
Speck
J A
JA
Veum-Stone
T
T
de Witte
M M
MM
Bortin
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000401:mortality / Q000706:statistics & numerical data*; D002423:Cause of Death; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000601:surgery*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery; D011336:Probability; D011658:Pulmonary Fibrosis / Q000453:epidemiology; D012042:Registries; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome