Placental transfer of (3H)-GM1 and its distribution to maternal and fetal tissues of the rat.
The demonstration that ganglioside GM1 pretreatment reduced the ethanol induced neurobehavioral effects in adult pups exposed to ethanol in utero, prompted study to examine whether GM1 crosses the placenta and penetrates fetal tissues. The present results indicate that 3H-galactose labeled GM1 not only passes the placenta but also served as a substrate for the synthesis of polysialogangliosides, and remained in various tissues up to 48 h after maternal (3H)-GM1 administration.
New York State Psychiatric Institute, NY 10032.
B L
BL
Hungund
H O
HO
Morishima
V S
VS
Gokhale
T B
TB
Cooper
D000818:Animals; D001692:Biological Transport; D002855:Chromatography, Thin Layer; D005260:Female; D005333:Fetus / Q000378:metabolism; D005677:G(M1) Ganglioside / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D005677:G(M1) Ganglioside