[Glucose utilization and risk of hyperglycemia during simultaneous administration of branched-chain amino acids and fat emulsions in healthy persons].
In order to evaluate the effect of substrate competition on glucose utilization, we studied 8 healthy volunteers under three different conditions: 1. Hyperinsulinemic (75 a 550 microU/ml) euglycemic (5 mmol/1) clamp (HEC). 2. HEC with Nutramin VLI infusion given at a rate of 2 ml/kg.h. 3. HEC with infusion of Nutramin VLI (2 ml/kg.h) and Intralipid (0.15 g of fat/kg.h). Glucose utilization was evaluated as the glucose disposal rate during HEC. We have found, that Nutramin VLI given alone or with Intralipid does not significantly decrease glucose utilization at insulinemia of about 75 and 550 microU/ml. We conclude that simultaneous administration of substrates during parenteral nutrition at standard rates does not raise the risk of hyperglycemia in healthy men.
Subkatedra diabetologie Institutu pro dalsí vzdĕlávání lékarú a farmaceutů, Praha.
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Pelikánová
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Kohout
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Válek
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Karasová
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Base
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Stefka
D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage* / Q000009:adverse effects; D001786:Blood Glucose / Q000378:metabolism; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D007262:Infusions, Intravenous; D008297:Male; D012307:Risk Factors
D000597:Amino Acids, Branched-Chain; D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous
Utilizace glukózy a riziko hyperglykémie pri soucasném podávání vĕtvených aminokyselin a tukové emulze u zdravých osob.