Acute myopathy associated with large parenteral dose of corticosteroid in myasthenia gravis.
A 13 year old Greek girl with myasthenia gravis developed widespread muscle paralysis and atrophy after large parenteral doses of corticosteroids (5.48 g methylprednisolone). An electromyogram showed myopathy, creatine kinase concentration below normal, and a muscle biopsy showed severe myopathy with selective loss of the thick filaments (myosin). Previous reports of myopathy associated with large steroid doses have mostly been in patients who were also receiving non-depolarising neuromuscular blocking drugs. This patient is unique in that severe myopathy was associated with neuromuscular blockade caused by antibodies to acetylcholine receptors. The findings in this case suggest that high doses of parenteral corticosteroids in patients with myasthenia gravis may be dangerous and that blocking the neuromuscular junction with drugs or antibodies predisposes skeletal muscles to the injurious effects of corticosteroids.
Department of Clinical Neurology, University of Oxford.
P K
PK
Panegyres
M
M
Squier
K R
KR
Mills
J
J
Newsom-Davis
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D009157:Myasthenia Gravis / Q000150:complications* / Q000188:drug therapy; D011950:Receptors, Cholinergic / Q000276:immunology
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D011950:Receptors, Cholinergic