Protection against vaginal SIV transmission with microencapsulated vaccine.
Although protection in animal models against intravenous challenges with simian immunodeficiency virus (SIV) has been reported, no previous vaccines have protected against a heterosexual route of infection. In this study, five of six macaques were protected against vaginal challenge when immunized with formalin-treated SIV in biodegradable microspheres by the intramuscular plus oral or plus intratracheal route. Oral immunization alone did not protect. After a second vaginal challenge, three of four intramuscularly primed and mucosally boosted macaques remained protected. The data suggest that protection against human immunodeficiency virus vaginal transmission could be provided by microsphere-based booster vaccines when used to immunize women who are systemically primed.
Marx
P A
PA
New Mexico Regional Primate Research Laboratory, New Mexico State University, Holloman Air Force Base 88330.
Compans
R W
RW
Gettie
A
A
Staas
J K
JK
Gilley
R M
RM
Mulligan
M J
MJ
Yamshchikov
G V
GV
Chen
D
D
Eldridge
J H
JH
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis* / Q000096:biosynthesis; D005260:Female; D007117:Immunization, Secondary; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D051379:Mice; D008863:Microspheres; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014132:Trachea; D014611:Vaccination; D014621:Vagina / Q000276:immunology* / Q000382:microbiology; D014765:Viral Vaccines / Q000008:administration & dosage
D000914:Antibodies, Viral; D014765:Viral Vaccines