alpha-Latrotoxin receptor. Implications in nerve terminal function.
alpha-Latrotoxin is a potent stimulator of neurotransmitter release from nerve terminals. High affinity membrane alpha-latrotoxin receptor was purified in an active binding form. It is a membrane glycoprotein (M(r) 160,000-220,000) which may be complexed to a smaller polypeptide (M(r) 29,000). The structure of the receptor protein suggests that it may be a synapse-specific cell recognition molecule. Intracellularly, the alpha-latrotoxin receptor interacts with synaptotagmin, a calcium- and phospholipid-binding protein specifically localized in the synaptic vesicle membrane. This interaction may be important for targeting of synaptic vesicles to presynaptic release sites.
Petrenko
A G
AG
Research Center of Molecular Diagnostics and Therapy, Moscow, Russian Federation.
D000818:Animals; D002135:Calcium-Binding Proteins; D003001:Cloning, Molecular; D008562:Membrane Glycoproteins / Q000502:physiology; D015394:Molecular Structure; D009411:Nerve Endings / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D011950:Receptors, Cholinergic / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018000:Receptors, Peptide; D050857:Synaptotagmins
D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011950:Receptors, Cholinergic; D018000:Receptors, Peptide; C034800:alpha-latrotoxin receptor; D050857:Synaptotagmins