[Mechanism of action of nitrates].
Nitrates' mechanisms of action are reviewed focusing on are reviewed its hemodynamic effects on the systemic circulation and particularly on the coronary circulation. The beneficial effect of its use is discussed both in angina pectoris and heart failure clinical situations. These drugs mechanisms of action are described, particularly at cellular level, explaining its importance as exogenous suppliers of nitric oxide, and the location of its receptors is discussed. Particular attention is given to the tolerance phenomenon observed when they are used in clinical practice.
Mourão
L
L
UCIM-Hospital de S. Francisco Xavier, Lisboa.
D004361:Drug Tolerance; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009566:Nitrates / Q000494:pharmacology*
D009566:Nitrates
Mecanismo de acção dos nitratos.