Structures of the modified folates in the extremely thermophilic archaebacterium Thermococcus litoralis.
The chemical structures of the two modified folates present in Thermococcus litoralis were established. These compounds, each containing a core structure of 1-[4-[[1-(2-amino-7-methyl- 4-oxo-6-pteridinyl)-ethyl]amino]phenyl]-1-deoxy-[1-alpha-D- ribofuranosyl]-ribitol, were characterized. The five position of the ribose in this core structure was beta-linked to the C-1 of a poly-beta (1-->4)N-acetylglucosamine having a chain length of four or five N-acetylglucosamine residues. Thus, these compounds are N-acetylglucosamine homologs of the modified folates found in Pyrococcus furiosus.
Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308.
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D000117:Acetylglucosamine / Q000031:analogs & derivatives*; D001105:Archaea / Q000737:chemistry*; D002240:Carbohydrate Sequence; D005492:Folic Acid / Q000031:analogs & derivatives*; D006358:Hot Temperature; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry
D009844:Oligosaccharides; D005492:Folic Acid; D000117:Acetylglucosamine