Role of prolonged stimulation of tamoxifen therapy in the etiology of endometrial sarcomas.
We present the first case of heterologous mixed mesodermal tumor that developed 9 years following tamoxifen therapy in a climacteric woman with no previous pelvic irradiation and was initially treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy. She continued tamoxifen therapy for 2 years, following the initial treatment, until the diagnosis of a recurrent tumor by laparotomy. The patient died of the disease 5 months subsequent to the second surgery. The association of prolonged unopposed estrogenic stimulation, with tamoxifen as a possible etiologic factor in the development of endometrial sarcomas, is discussed.
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.
M M
MM
Altaras
R
R
Aviram
I
I
Cohen
M
M
Cordoba
S
S
Yarkoni
Y
Y
Beyth
D000368:Aged; D016889:Endometrial Neoplasms / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D012509:Sarcoma / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects*
D013629:Tamoxifen