Cholesterol 7 alpha hydroxylase promoter separated from cyclophilin pseudogene by Alu sequence.
The promoter for human cholesterol 7-alpha hydroxylase has been cloned and sequenced. In the regions previously described, our sequence agrees well with one report but not with another. At position -469, we find a widespread MaeII polymorphism. At -2636, there is an Alu sequence flanked by runs of adenines. Upstream of the Alu sequence, there is a cyclophilin pseudogene oriented in the opposite direction.
Molecular Genetics and Protein Chemistry Research Department, Pfizer Inc., Groton, CT 06340.
J F
JF
Thompson
M E
ME
Lira
D B
DB
Lloyd
L S
LS
Hayes
S
S
Williams
L
L
Elsenboss
D000591:Amino Acid Isomerases / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics*; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D019696:Peptidylprolyl Isomerase; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011544:Pseudogenes; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment
D002352:Carrier Proteins; D002790:Cholesterol 7-alpha-Hydroxylase; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase