Involvement of regions of the 4th and 7th chromosomes in the open-field activity of mice.
Reactivity to a new environment was studied in mice, using an open-field procedure in two strains, C57BL/6By and ABP/Le, the F1 populations and the intercrosses F2 and backcross segregating populations. The analysis of the behavioral traits: peripheral and central activities, leaning, rearing and defecation in the parental strains made it possible to show that the ABP/Le strain was more reactive than C57BL/6By. In addition, the study of segregating, for four phenotypic markers, in F2 and backcross populations strongly suggested that two autosomal regions were involved in the control of open-field behavior: one in chromosomal region comprising the b locus on chromosome 4 and one in chromosomal region comprising the p locus on chromosome 7.
U.R.A C.N.R.S. 1294, U.F.R Biomédicale des Saints-Pères, Université Paris V, France.
Y
Y
Clément
B
B
Martin
P
P
Venault
G
G
Chapouthier
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology*; D003672:Defecation / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D005819:Genetic Markers; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000502:physiology; D010641:Phenotype
D005819:Genetic Markers