[Synthetic studies on highly modified nucleosides directed towards creation of anti-HIV agents].
Recent studies on the synthesis of highly modified nucleosides, especially carbocyclic nucleosides, aiming at creating anti-HIV agents have been reviewed. The review includes new methods for the synthesis of carbocyclic C-nucleosides and carbocyclic N-nucleosides including carbocyclic oxetanocin and its analogues developed in our laboratory. Among the carbocyclic nucleosides synthesized, 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) showed significant anti-HIV activity.
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
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Katagiri
D015195:Drug Design; D006678:HIV / Q000187:drug effects*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D009705:Nucleosides