[Changes in the morphology of the thymus and spleen of healthy mice in combined exposure to nitrosomethylurea and immunomodulators].
Changes in the histological structure of thymus and spleen, changes in the area of immune organs occupied by T- and B-lymphocytes and their proliferative activity were studied after the separate and combined treatment of the healthy mice with nitrosomethylurea (NMU), thymalin and Reaferon. NMU alone damaged the lymphoid organs with subsequent incomplete restoration of their histological structure due to pronounced sclerosis. The combined use of NMU and of immunomodulators did not change the NMU acute toxicity but reduced its distant effects.
Iu N
IuN
Potapov
V S
VS
Pashkova
T V
TV
Krutova
D V
DV
Khaleev
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D007370:Interferon Type I / Q000494:pharmacology; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D013951:Thymus Hormones / Q000494:pharmacology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013951:Thymus Hormones; D008770:Methylnitrosourea; C032805:thymalin
Izmenenie morfologii timusa i selezenki zdorovykh mysheĭ pri sochetannom vozdeĭstvii nitrozometilmocheviny i immunomoduliatorov.