Lessons from lethal albino mice.
Results from the analysis of mice homozygous for lethal albino deletions suggested the existence of a locus involved in the regulation of gene expression in the liver. The surprising finding that the locus encodes an enzyme active in tyrosine metabolism forces us to re-evaluate the lethal albino phenotype and advises caution in the interpretation of seemingly simple phenotypes.
Division Molecular Biology of Cell I, German Cancer Research Center, Heidelberg.
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Kelsey
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Schütz
D000417:Albinism / Q000235:genetics*; D000818:Animals; D000831:Animals, Newborn / Q000235:genetics / Q000378:metabolism; D017353:Gene Deletion; D005786:Gene Expression Regulation; D005804:Genes, Lethal; D006801:Humans; D006867:Hydrolases / Q000172:deficiency / Q000235:genetics*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D008822:Mice, Transgenic; D008954:Models, Biological; D009928:Organ Specificity; D010641:Phenotype; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic; D014443:Tyrosine / Q000378:metabolism*
D014157:Transcription Factors; D014443:Tyrosine; D006867:Hydrolases; C020156:fumarylacetoacetase