Two proto-oncogenes that play dual roles in embryonal cell growth and differentiation.
The function of growth factors in early development is reviewed. Special emphasis is on the epidermal growth factor and its receptor, and on the c-fos and its family of transcriptional factor proteins, which play an important role in modulating the growth and differentiation of early embryos and embryonal carcinoma cells.
Adamson
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La Jolla Cancer Research Foundation, CA 92037.
D000818:Animals; D001755:Blastocyst / Q000737:chemistry*; D002454:Cell Differentiation; D054278:Embryonal Carcinoma Stem Cells; D004815:Epidermal Growth Factor / Q000235:genetics / Q000502:physiology*; D066246:ErbB Receptors / Q000032:analysis / Q000502:physiology*; D016758:Genes, jun; D051379:Mice; D014411:Neoplastic Stem Cells / Q000737:chemistry; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000502:physiology*; D015398:Signal Transduction; D013724:Teratoma / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos; D004815:Epidermal Growth Factor; D066246:ErbB Receptors