Propachlor-S-cysteine: a major circulating metabolite in the calf, pig and rat after administration of propachlor.
1. Propachlor-S-cysteine was the major metabolite found in systemic blood from rat, pig and calf given propachlor via the stomach. It was also the major metabolite found in the portal blood of pig; the portal blood of rat and calf was not examined. 2. Erythrocytes were the major transporter of propachlor metabolites in rat blood whereas plasma was the major transporter of these metabolites in pig and calf. 3. There was no evidence for metabolism of propachlor-S-cysteine by rat blood or by cytosol from rat, pig and calf erythrocytes.
US Department of Agriculture, Biosciences Research Laboratory, Fargo, ND 58105.
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Davison
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Larsen
D000083:Acetanilides / Q000097:blood* / Q000493:pharmacokinetics; D000818:Animals; D002250:Carbon Radioisotopes; D002417:Cattle; D003545:Cysteine / Q000031:analogs & derivatives / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D007408:Intestinal Absorption; D007601:Jugular Veins; D008297:Male; D011169:Portal Vein; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013552:Swine
D000083:Acetanilides; D002250:Carbon Radioisotopes; C011088:propachlor; D003545:Cysteine