Pathogenesis and animal studies of Parkinson's disease.
This article reviews the past year's literature on pathogenesis and animal studies of Parkinson's disease. Studies on aging, genetic aspects, environmental factors, melanin, altered iron metabolism, oxidative stress, defective mitochondrial respiration, excitatory amino acids, and trophic support are reviewed in relation to the vulnerability of dopaminergic nigral neurons and the pathogenesis of Parkinson's disease.
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, München, Germany.
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Oertel
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Kupsch
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007501:Iron / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000503:physiopathology
D017382:Reactive Oxygen Species; D011954:Receptors, Dopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D007501:Iron; D004298:Dopamine