Neurological manifestations of hemorrhagic colitis in the outbreak of Escherichia coli O157:H7 infection in Japan.
An outbreak of hemorrhagic colitis associated with Escherichia coli O157:H7 occurred in a kindergarten in Saitama, Japan from September to November, 1990. Seven patients admitted to our hospital showed neurological manifestations: generalized seizures, impaired consciousness, urinary incontinence, gaze nystagmus, phrenic nerve palsy, action tremor and vertigo. Two patients died. On the basis of the clinical courses and laboratory findings of the seven patients and postmortem findings of one case, these neurological symptoms were suspected to be induced by the verotoxin elaborated by Escherichia coli O157:H7.
Division of Neurology, Saitama Children's Medical Center, Japan.
S
S
Hamano
Y
Y
Nakanishi
T
T
Nara
T
T
Seki
T
T
Ohtani
T
T
Oishi
K
K
Joh
T
T
Oikawa
Y
Y
Muramatsu
Y
Y
Ogawa
D001427:Bacterial Toxins / Q000009:adverse effects / Q000096:biosynthesis; D016022:Case-Control Studies; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D004196:Disease Outbreaks; D004768:Enterotoxins / Q000009:adverse effects / Q000096:biosynthesis; D004926:Escherichia coli / Q000378:metabolism; D004927:Escherichia coli Infections / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006463:Hemolytic-Uremic Syndrome; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology
D001427:Bacterial Toxins; D004768:Enterotoxins