Predictive value of placebo methylphenidate.
The effects of methylphenidate in 20 children with attention-deficit disorder between the ages of 7 and 12 years were assessed in a double-blind, placebo/drug counterbalanced study. Measures of outcome included the Teacher Rating Scale and Abbreviated Parent Rating Scale: digits, words, and visual sequencing; motor control; and a maze test. The Teacher Rating Scale placebo-drug difference correlated more significantly with the outcome measures than the baseline-drug difference. The study underlines the validity of a multimeasure placebo/drug trial in evaluating the efficacy of methylphenidate in children with attention-deficit disorder.
Hannah Khoushy Child Development Center, Bnai Zion Medical Center, Haifa, Israel.
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E
Tirosh
R
R
Elhasid
S C
SC
Kamah
A
A
Cohen
D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D010552:Personality Assessment; D015990:Placebo Effect; D011340:Problem Solving / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects
D008774:Methylphenidate