The effect of epitestosterone on the plasma levels of LH and FSH in ovariectomized immature rats.
Immature ovariectomized female rats primed with estradiol or without estrogen priming were treated with epitestosterone i.p. After 7 h blood was collected and LH and FSH levels were determined. The dose-response relationship was a biphasic one. LH and less markedly FSH levels decreased under epitestosterone treatment with doses up to 10 mg, whereas at higher doses an increase of gonadotrophins was observed.
Institute of Endocrinology, Prague, Czech Republic.
M
M
Bicíková
R
R
Kanceva
O
O
Lapcík
M
M
Hill
L
L
Stárka
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004845:Epitestosterone / Q000008:administration & dosage / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007274:Injections, Intraperitoneal; D007986:Luteinizing Hormone / Q000097:blood*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000187:drug effects
D011960:Receptors, Estrogen; D004845:Epitestosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone