Renal function impairment in workers previously exposed to cadmium.
Cadmium-induced renal effects were followed (1989) in 16 workers previously exposed to cadmium, who had been shown 5 years earlier to have had tubular damage; all but 1 worker had persistent tubular damage (beta 2-microglobulin > 60 micrograms/mmol creatinine). The mean glomerular filtration rate (GFR) decreased from 77.3 to 71.7 ml/min/1.73 m2, which is 2.0 ml/min more than would have been expected from aging only. There was a negative correlation between loss of tubular function (relative clearance of beta 2-microglobulin) and the ratio of observed versus reference GFRs in accordance with a 1984 study. The results confirm that cadmium-induced tubular damage is irreversible. They also suggest that the glomerular dysfunction after cadmium exposure is irreversible and progressive also after exposure stops. A nonsignificant correlation was found between cumulative cadmium exposure and decreased GFR.
Department of Occupational Medicine, Karolinska Hospital Stockholm, Sweden.
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Järup
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Persson
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Edling
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Elinder
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002105:Cadmium Poisoning / Q000209:etiology / Q000503:physiopathology*; D003404:Creatinine / Q000652:urine; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D007684:Kidney Tubules / Q000187:drug effects / Q000293:injuries / Q000503:physiopathology; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology / Q000503:physiopathology; D016273:Occupational Exposure; D013548:Sweden; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D003404:Creatinine