Nitric oxide in IgA nephropathy patients with or without hypertension.
Nitric oxide (NO) is claimed to have a role in the pathogenesis of immune-mediated glomerulonephritis and in the regulation of blood pressure (BP). NO rapidly converts to NO2-/NO3- which is excreted in the urine. We determined the daily NO2-/NO3- excretion in 26 IgA nephropathy (NP) patients and 20 healthy controls, recording the BP in each. There was no difference in NO2-/NO3- excretion between IgA NP patients and controls (999.1 +/- 66.8 vs. 1,051.2 +/- 53.0 mumol/day). The urinary excretion of NO2-/NO3- in IgA NP patients whose mean diastolic BP remained above 85 mm Hg in spite of antihypertensive therapy, was significantly decreased (n = 8; 734.38 +/- 87.83 mumol/day; p < 0.05). There was a significant inverse correlation between mean diastolic BP and urinary NO2-/NO3- (p < 0.006). NO2-/NO3- excretion decreased with aging (p < 0.01) in IgA NP patients, but not in controls. The fact that there was no difference between the urinary NO2-/NO3- excretion of IgA NP patients and controls argues against the idea that NO production in immune-mediated IgA NP can be increased. The decrease of urinary NO2-/NO3- in hypertensive and in older IgA NP patients may be correlated with the impaired NO production of the endothelium.
Nephrology Center of Second Department of Medicine, University Medical School of Pécs, Hungary.
T
T
Kovács
J
J
Barta
B
B
Kocsis
J
J
Nagy
D000328:Adult; D000368:Aged; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000378:metabolism* / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000652:urine; D009569:Nitric Oxide / Q000378:metabolism* / Q000652:urine; D009573:Nitrites / Q000652:urine
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide