Striatal dopaminergic denervation in pallidopyramidal disease demonstrated by positron emission tomography.
Pallidopyramidal disease is a rare disease of young patients in which they manifest a parkinsonian syndrome and pyramidal signs. Pallidopyramidal disease has been attributed to a degeneration of the pallidum and the pyramidal tract, although only 1 patient has been studied postmortem. In the present report, [18F]fluorodopa positron emission tomography in 2 patients showed a marked dopaminergic denervation of the striatum, suggesting that this disease corresponds more to a nigropallidopyramidal dysfunction.
Remy
P
P
Commissariat à l'Energie Atomique, Service Hospitalier Frédéric Joliot, Orsay, France.
Hosseini
H
H
Degos
J D
JD
Samson
Y
Y
Agid
Y
Y
Warter
J M
JM
Vidailhet
M
M
D000293:Adolescent; D002421:Caudate Nucleus / Q000378:metabolism / Q000503:physiopathology; D002648:Child; D003714:Denervation; D004295:Dihydroxyphenylalanine; D004298:Dopamine / Q000502:physiology*; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D017072:Neostriatum / Q000166:cytology / Q000503:physiopathology*; D011699:Putamen / Q000378:metabolism / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D004295:Dihydroxyphenylalanine; D004298:Dopamine