Effects of sevoflurane anaesthesia on renal function--duration of administration and area under the curve and rate of decrease of serum inorganic fluoride.
The renal effects of serum inorganic fluoride in sevoflurane anaesthesia were studied in 15 patients separated into two groups according to whether anaesthesia had lasted more than 7 h. Serum and urine fluoride and beta 2-microglobulin, blood urea nitrogen, and serum creatinine were measured during and after anaesthesia. The area under the curve of serum fluoride (AUC0-infinity) was significantly higher for longer anaesthesia (more than 7 h), but serum fluoride at the end of inhalation and the rate of decrease of serum fluoride were similar in both groups. Although urine beta 2-microglobulin increased above normal after anaesthesia, there were no significant differences between groups. Other indices of renal function remained normal. Sevoflurane dose, duration of administration, serum fluoride at the end of inhalation, area under the curve and rate of decrease of serum fluoride were compared against indices of renal function using Spearman's rank correlated index. The only significant correlation was serum fluoride at the end of inhalation with serum creatinine. The duration of sevoflurane administration and the area under the curve for serum fluoride did not affect renal function.
Department of Anesthesiology, JR Tokyo General Hospital, Japan.
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Nishiyama
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Hirasaki
D000758:Anesthesia / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D004987:Ethers / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000652:urine; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D000077149:Sevoflurane; D001613:beta 2-Microglobulin / Q000378:metabolism
D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D001613:beta 2-Microglobulin; D000077149:Sevoflurane; D003404:Creatinine; D005459:Fluorides