EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.
The frequencies of certain periodic behaviors of the nematode C. elegans are regulated in a dose-dependent manner by the activity of the gene egl-10. These behaviors are modulated oppositely by the activity of the G protein alpha subunit gene goa-1, suggesting that egl-10 may regulate a G protein signaling pathway in a dose-dependent fashion. egl-10 encodes a protein similar to Sst2p, a negative regulator of G protein signaling in yeast. EGL-10 protein is localized in neural processes, where it may function in neurotransmitter signaling. Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways.
Koelle
M R
MR
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Horvitz
H R
HR
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D017124:Conserved Sequence / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics; D019204:GTP-Binding Proteins / Q000032:analysis / Q000235:genetics*; D018628:Gene Dosage; D017238:Genes, Helminth / Q000502:physiology*; D008322:Mammals; D008969:Molecular Sequence Data; D009132:Muscles / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D009154:Mutation / Q000235:genetics; D009420:Nervous System / Q000737:chemistry; D009424:Nervous System Physiological Phenomena; D010063:Ovum / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D020710:RGS Proteins; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D015003:Yeasts / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; C105577:EGL-10 protein, C elegans; D005656:Fungal Proteins; D011506:Proteins; D020710:RGS Proteins; D012701:Serotonin; D019204:GTP-Binding Proteins