Phototoxic and photoprotective effects of topical isothipendyl.
Isothipendyl, an H1-receptor antagonist, is an antihistamine used as an antiallergic drug. Its molecular structure is close to the phenothiazines, but it has different photobiological properties. Like phenothiazines, isothipendyl is phototoxic with ultraviolet A (UVA) but it reduces the erythema response to UVB radiation. Isothipenyl seems to have the same protective properties as a sunscreen because its UVB protective properties are effective only if the substance is applied prior to exposure.
Service de Dermatologie, Centre Hospitalier Universitaire, Caen, France.
A
A
Moreau
A
A
Dompmartin
A
A
Dubreuil
D
D
Leroy
D018926:Anti-Allergic Agents / Q000494:pharmacology; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D004492:Edetic Acid / Q000009:adverse effects; D004890:Erythema / Q000517:prevention & control; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000209:etiology; D011398:Promethazine / Q000009:adverse effects; D013473:Sunscreening Agents / Q000494:pharmacology*; D013843:Thiazines / Q000009:adverse effects / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects / Q000145:classification
D018926:Anti-Allergic Agents; D006635:Histamine H2 Antagonists; D013473:Sunscreening Agents; D013843:Thiazines; D004492:Edetic Acid; D011398:Promethazine; C008214:isothipendyl