Follow-up of spongiosa plugs with contrast enhanced magnetic resonance imaging.
The aim of this study was to evaluate the extent and duration of the revascularization process in spongiosa plugs when a fibrin sealant was used. 20 patients with tumour-like lesions, benign tumours and tumours with a potential for malignant transformation were studied. After intralesional tumour removal, the defect was filled with homologous spongiosa either combined with or without a fibrin sealant, according to a prospective randomization. Magnetic resonance imaging (MRI) follow-up examinations were performed within 1 week, and 1.5, 3, 4.5, 6, 8, 12, 24 and 36 months after surgery. Those patients without a fibrin sealant showed an increased revascularization zone up to the sixth week. Patients treated with fibrin, however, showed increased revascularization up to 3 months. In the 25% percentile the extent as well as the rate of revascularization is higher in those with a fibrin sealant. It is of clinical relevance that no revascularization should be expected at 3 months after surgery, which is easily demonstrated by MR follow-up.
Kramer
J
J
MR Institute, University of Vienna, Austria.
Schiller
C
C
Lang
S
S
Frodl
J
J
Hornberger
C
C
Andrea
K
K
Steiner
E
E
Imhof
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation; D001842:Bone and Bones / Q000098:blood supply*; D005260:Female; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D018919:Neovascularization, Physiologic; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D015718:Fibrin Tissue Adhesive