Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients.
The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.
Suzuki
Y
Y
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301, USA.
Wong
S Y
SY
Grumet
F C
FC
Fessel
J
J
Montoya
J G
JG
Zolopa
A R
AR
Portmore
A
A
Schumacher-Perdreau
F
F
Schrappe
M
M
Köppen
S
S
Ruf
B
B
Brown
B W
BW
Remington
J S
JS
D017088:AIDS-Related Opportunistic Infections / Q000235:genetics* / Q000276:immunology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004198:Disease Susceptibility; D004660:Encephalitis / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D016781:Toxoplasmosis, Cerebral / Q000235:genetics*
D005819:Genetic Markers; D006683:HLA-DQ Antigens