Association study of schizophrenia and the IL-2 receptor beta chain gene.
A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2R beta chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2R beta gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.
Nimgaonkar
V L
VL
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA.
Yang
Z W
ZW
Zhang
X R
XR
Brar
J S
JS
Chakravarti
A
A
Ganguli
R
R
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D015375:Receptors, Interleukin-2 / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D044465:White People
D015375:Receptors, Interleukin-2