Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit.
A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.
Heinemann
S H
SH
Max-Planck-Gesellschaft z.Ed.W. c.V. AG Molecular und zelluläre, Biophysik, Jena, Germany.
Rettig
J
J
Wunder
F
F
Pongs
O
O
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D018076:DNA, Complementary / Q000235:genetics; D004553:Electric Conductivity; D015723:Gene Library; D051038:Large-Conductance Calcium-Activated Potassium Channel beta Subunits; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D009865:Oocytes; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D011487:Protein Conformation; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014981:Xenopus
D018076:DNA, Complementary; C494840:Kcnab3 protein, rat; D051038:Large-Conductance Calcium-Activated Potassium Channel beta Subunits; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D012333:RNA, Messenger