Stable isotope identification of lead sources in preschool children--the Omaha Study.
The objective was to determine, from analysis of the naturally occurring stable isotopes of lead, the relative contribution of food, handdust, housedust, soil and air lead to the absorbed (urinary) lead and the blood lead of children living in a former smelter city. A longitudinal 12 month study was conducted of 21 children, 2 - 3 years of age, living in central Omaha, balanced for race, gender and socioeconomic status. Field clean samples were collected monthly of 24 hour duplicate diet, handwipe and urine, with quarterly blood lead, annual environmental lead, weekly air for total lead and 206Pb, 207Pb and 208Pb by thermal ionization/mass spectrometry with a 205Pb spike in a Class II laboratory. Despite residence in a smelter city each child had a unique isotopic ratio of handwipe, blood and urine lead, the latter being identical. There was no correlation of handwipe isotopic ratio with proximity to a lead emission source or to the decade of the housing stock. The isotopic ratio of the annual mean handwipe lead predicted 43% of the variance of the annual mean blood and urine lead ratio (r2 = .43; p = .001). Handwipe lead ratios correlated (p < or = .05) with those of the windowsills and air ducts. The mean isotopic ratios of blood and urine lead were lower than those of handwipe and food, consistent with a contribution by endogenous bone lead. Clean catch urine provides a noninvasive index of blood lead isotopic ratio in children, as in adults.
Angle
C R
CR
University of Nebraska Medical Center, Omaha 68198-6055, USA.
Manton
W I
WI
Stanek
K L
KL
D002675:Child, Preschool; D004784:Environmental Monitoring; D004787:Environmental Pollution; D005260:Female; D005506:Food Contamination; D006801:Humans; D007554:Isotopes; D007854:Lead / Q000032:analysis*; D008137:Longitudinal Studies; D008297:Male; D009329:Nebraska
D007554:Isotopes; D007854:Lead