[Preparation of aryloxyaminopropanol derivatives with potential effects on the cardiovascular system].
The synthesis of nine compounds belonging to the group of aryloxyaminopropanols with carbamate substitutions of the aromatic ring is described and pharmacologically evaluated. The results suggest that an addition of N-phenyl-piperazine derivatives to the main basic moiety can exert a positive influence on their beta-adrenolytic, antiarrhytmic or antihypertensive activity.
Hlavácová
H
H
Katedra farmaceutické chemie Farmaceutické fakulty Univerzity Komenského, Bratislava.
Csöllei
J
J
Seginko
J
J
D000818:Animals; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D011412:Propanolamines / Q000138:chemical synthesis* / Q000737:chemistry
D002317:Cardiovascular Agents; D010879:Piperazines; D011412:Propanolamines
Príprava derivátů aryloxyaminopropanolů s potenciálním úcinkem na kardiovaskulární systém.