Site-directed mutagenesis of baboon CD14 to the human sequence allows for antibody recognition and enhanced LPS binding.
R.W. Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA.
J S
JS
DeGraw
J
J
Gao
D J
DJ
Leturcq
G B
GB
Thornton
A M
AM
Moriarty
D000818:Animals; D000911:Antibodies, Monoclonal; D001665:Binding Sites; D016466:CHO Cells; D003001:Cloning, Molecular; D006224:Cricetinae; D004195:Disease Models, Animal; D004351:Drug Resistance; D016905:Gram-Negative Bacterial Infections / Q000209:etiology; D000882:Haplorhini; D006801:Humans; D066298:In Vitro Techniques; D018950:Lipopolysaccharide Receptors / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000378:metabolism* / Q000633:toxicity; D016297:Mutagenesis, Site-Directed; D010215:Papio; D012772:Shock, Septic / Q000209:etiology; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides