Elevated levels of the chromosomal protein HMG 17 in chronic myelogenic leukemia.
The High Mobility Group protein HMG 17 has been isolated from human leukemia cells obtained from patients with chronic myelogenic leukemia (CML). The level of expression of HMG 17 was investigated Human leukemia cells have three times more HMG 17 than normal human leukocytes. Three other malignant tissues were also compared. Two of these breast adenocarcinoma and other intestine- also exhibit higher amounts of HMG 17. The elevated expression of HMG 17 suggests that the level of the protein may be associated with rates of cellular proliferation.
Department of Biochemistry, Cell and Molecular Biology and Genetics, University of Athens, Greece.
H
H
Kondos
E
E
Anastasiadou
A
A
Photopoulou
P
P
Cary
V
V
Aleporou-Marinou
T
T
Pataryas
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000097:blood* / Q000302:isolation & purification; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism*; D008970:Molecular Weight; D012016:Reference Values; D013950:Thymus Gland / Q000378:metabolism
D000596:Amino Acids; D006609:High Mobility Group Proteins