Occupational allergic contact dermatitis caused by epoxy diacrylate in ultraviolet-light-cured paint, and bisphenol A in dental composite resin.
Allergic contact dermatitis (ACD) caused by epoxy di(meth)acrylates or bisphenol A is rare. Here 2 such cases are reported. A dental assistant had allergic contact dermatitis (ACD) caused by bisphenol A contained in dental composite resin (DCR) products based on epoxy dimethacrylate. The contact allergy was verified by allergic patch test reactions to bisphenol A and 2 DCRs. The DCRs giving allergic reactions were analyzed, and 0.014-0.015% of bisphenol A was detected. Occupational ACD caused by bisphenol A in dental composite resins has not been described before. The other patient was a male process worker in a paint factory. He was sensitized by an epoxy diacrylate, 2,2-bis[4-(2-hydroxy-3-acryloxypropoxy)phenyl]-propane (BIS-GA), and other acrylate compounds contained in raw materials of ultraviolet-light-curable paint. The epoxy diacrylate gave an allergic patch test reaction down to 0.016% in pet. He also had an allergic patch test reaction to several other acrylate compounds, 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, 1,4-butanediol diacrylate, 1,6-hexanediol diacrylate, diethyleneglycol diacrylate, triethylene glycol diacrylate, and tripropylene glycol diacrylate, indicating cross and/or concomitant sensitization.
Section of Dermatology, Finnish Institute of Occupational Health, Helsinki, Finland.
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Jolanki
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Kanerva
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Estlander
D000179:Acrylates / Q000009:adverse effects* / Q000737:chemistry; D000328:Adult; D001559:Benzhydryl Compounds; D002617:Chemical Industry; D003764:Dental Materials / Q000009:adverse effects; D003800:Dental Technicians; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D004853:Epoxy Resins / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D006229:Hand Dermatoses / Q000209:etiology*; D006801:Humans; D008297:Male; D010150:Paint / Q000009:adverse effects; D010328:Patch Tests; D010636:Phenols / Q000009:adverse effects* / Q000737:chemistry; D014466:Ultraviolet Rays; D000098826:Bisphenol A Compounds
D000179:Acrylates; D001559:Benzhydryl Compounds; D003764:Dental Materials; D004853:Epoxy Resins; D010636:Phenols; C534778:2,2-bis(4-(2-hydroxy-3-acryloxypropoxy)phenyl)propane; C029420:bisphenol A epoxy resin diacrylate ester; D000098826:Bisphenol A Compounds; C006780:bisphenol A