[General perioperative prevention of thromboembolism in gynecology with low-molecular weight heparin: clinical experiences with enoxaparin over 7 years].
We report on clinical experiences with a low molecular weight heparin (Enoxaparin). Altogether 2339 patients undergoing gynecologic surgery received 20 or 40 mg Enoxaparin once a day beginning 2 hours before surgery. The dose was chosen depending on an assessment of the individual risk factors for each patient. No deep venous thrombosis and no pulmonary embolism were observed. Major intra- or postoperative bleeding was rare (0.3%). We considered these results as favorable. However, early physical therapy and mobilisation of the patients may present an important factor. Most importantly, dose adjustment according to individual risk assessment appears to be a very effective concept with respect to clinical management in gynecologic surgery.
Abteilung für Frauenheilkunde und Geburtshilfe des Allg. öffentl. Krankenhauses, Klosterneuburg, Osterreich.
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R
Slunsky
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D001780:Blood Coagulation Tests; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004434:Early Ambulation; D017984:Enoxaparin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood / Q000601:surgery*; D006801:Humans; D007279:Injections, Subcutaneous; D008875:Middle Aged; D026741:Physical Therapy Modalities; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D011292:Premedication; D011655:Pulmonary Embolism / Q000097:blood / Q000517:prevention & control*; D012307:Risk Factors; D013924:Thrombophlebitis / Q000097:blood / Q000517:prevention & control*
D000925:Anticoagulants; D017984:Enoxaparin
Generelle perioperative Thromboembolie-Prophylaxe in der Gynäkologie mit niedermolekularem Heparin: Klinische Erfahrungen mit Enoxaparin über einen Zeitraum von 7 Jahren.