Evaluation of the results of endotoxic shock (ES) treatment with dopamine (DA) and hydrocortisone (H).
The aim of this report is to present complex evaluation of the applied treatment with dopamine (DA) and hydrocortisone (H) in experimental endotoxic shock (ES). An evaluation is based on long-term experiences of the author's Clinic. The studies were performed in dogs. ES was evoked by intravenous E. coli endotoxin administration in a dose of 2 mg/kg. An appearance and progress of ES was evaluated by determination of many hemodynamic and biochemical parameters. In the treatment DA and H were used. Besides of mentioned above parameters also morphological, histochemical and ultrastructural investigations of the lung and liver were done. DA and H applied together were the most effective treatment in the course of ES. It could be a theoretical ground for combined ES treatment in people.
Department of General Surgery, Medical Academy of Białystok.
J
J
Barczyk
J R
JR
Ladny
L
L
Trochimowicz
Z
Z
Puchalski
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004285:Dogs; D004298:Dopamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006854:Hydrocortisone / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D000893:Anti-Inflammatory Agents; D004298:Dopamine; D006854:Hydrocortisone