Acute hepatic and renal failure caused by Pneumocystis carinii in patients with AIDS.
Clinical and pathological findings are described in two AIDS patients with Pneumocystis carinii infection who received prophylactic treatment with nebulised pentamidine and developed unusual hepatic and renal failure. Histological examination showed clumps of P carinii massively obstructing hepatic sinuses and portal vessels in the first patient, and merular and intertubular capillaries in the second. These findings could explain the unusual clinical features, characterised by acute hepatic and renal failure.
Dipartimento di Scienze Mediche, II Facoltà di Medicina e Chirurgia di Novara-Università di Torino, Italy.
R
R
Boldorini
S
S
Guzzetti
L
L
Meroni
T
T
Quirino
S
S
Cristina
G
G
Monga
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000382:microbiology* / Q000473:pathology; D008297:Male; D010419:Pentamidine / Q000627:therapeutic use; D016720:Pneumocystis Infections / Q000150:complications*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy; D051437:Renal Insufficiency / Q000382:microbiology* / Q000473:pathology
D000935:Antifungal Agents; D010419:Pentamidine