The effect of nasolacrimal occlusion on drug-induced mydriasis.
BACKGROUND
Nasolacrimal occlusion has been shown to improve the efficacy of some topically applied ocular drugs. The aim of this study was to investigate the effect of nasolacrimal occlusion on tropicamide-induced mydriasis.


METHODS
We compared pupillary dilatation by 0.125% tropicamide with and without nasolacrimal occlusion in 40 healthy volunteers.


RESULTS
Analysis of variance with repeated measures failed to show any advantage due to nasolacrimal occlusion in drug-induced mydriasis.


CONCLUSIONS
Nasolacrimal occlusion did not increase the mydriasis obtained with 0.125% tropicamide.
Department of Ophthalmology, Ichilov Hospital, Tel-Aviv, Israel.
A
A
Loewenstein
A
A
Sadeh
M
M
Goldstein
M
M
Lazar
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004311:Double-Blind Method; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000503:physiopathology*; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage*; D009301:Nasolacrimal Duct / Q000503:physiopathology*; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects / Q000502:physiology*; D014331:Tropicamide / Q000008:administration & dosage*
D009184:Mydriatics; D009883:Ophthalmic Solutions; D014331:Tropicamide