[An experimental study of the effect of an artichoke preparation on the activity of the sympathetic-adrenal system in carbon disulfide exposure].
Artichoke, a new Bulgarian preparation based on the plant Cynara scolymus, was tested for influence on sympatho-adrenal system (SAS) activity in experimental inhalation exposure to carbon disulfide. This chronic (six-month) inhalation experiment was done on Wistar albino rats of either sex. Activity of SAS was assessed through excretion of noradrenalin and adrenalin. Findings indicated a phasic SAS response depending on concentration and duration of carbon disulfide exposure. With exposure to 30 mg.m3, SAS activity was observed to decrease in the second month, followed by increase in the fourth and sixth months. With exposure to 300 mg.m3, SAS activity was elevated over the whole period of study. Under the influence of the preparation artichoke at dosage 200 mg.kg-1, catecholamines, increased by carbon disulfide exposure, returned to normal. This trend was more marked for noradrenalin.
Khalkova
Zh
Zh
Vangelova
K
K
Zaĭkov
Kh
Kh
D000311:Adrenal Glands / Q000187:drug effects*; D000704:Analysis of Variance; D000818:Animals; D000931:Antidotes / Q000494:pharmacology* / Q000627:therapeutic use; D002246:Carbon Disulfide / Q000506:poisoning*; D002395:Catecholamines / Q000652:urine; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy / Q000209:etiology / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013997:Time Factors; D014675:Vegetables
D000931:Antidotes; D002395:Catecholamines; D010936:Plant Extracts; D002246:Carbon Disulfide
Eksperimentalno prouchvane na vliianieto na preparata artishok vŭrkhu aktivnostta na simpatiko-adrenalnata sistema pri ekspozitsiia na serovŭglerod.