A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk.
The associations between lung cancer risk, mutagen sensitivity (a marker of cancer susceptibility), and a putative lung carcinogen, wood dust, were assessed in a hospital-based case-control study. There were 113 African -American and 67 Mexican-American cases with newly diagnosed, previously untreated lung cancer and 270 controls, frequency-matched on age, ethnicity, and sex. Mutagen sensitivity ( 1 chromatid break/cell after short-term bleomycin treatment) was associated with statistically significant elevated risk for lung cancer [odds ration (OR) = 4.3; 95% confidence intervals (CI) = 2.3-7.9]. Wood dust exposure was also a significant predictor of risk (overall OR = 3.5; CI = 1.4-8.6) after controlling for smoking and mutagen sensitivity. When stratified by ethnicity, wood dust exposure was s significant risk factor for African-Americans (OR = 5.5; CI = 1.6-18.9) but not for Mexican-Americans (OR = 2.0; CI = 0.5-8.1). The ORs were 3.8 and 4.8 for non-small cell lung cancer in Mexican-Americans (CI = 1.2-18.5). Stratified analysis suggested evidence of strong interactions between wood dust exposure and both mutagen sensitivity and smoking in lung cancer risk.
Wu
X
X
Department of epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Delclos
G L
GL
Annegers
J F
JF
Bondy
M L
ML
Honn
S E
SE
Henry
B
B
Hsu
T C
TC
Spitz
M R
MR
D000328:Adult; D017677:Age Distribution; D000368:Aged; D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D016001:Confidence Intervals; D004391:Dust / Q000009:adverse effects*; D005260:Female; D016468:Forestry; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D008297:Male; D017058:Mexican Americans / Q000235:genetics / Q000706:statistics & numerical data; D008875:Middle Aged; D009152:Mutagenicity Tests; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D018570:Risk Assessment; D017678:Sex Distribution; D012907:Smoking; D013781:Texas / Q000453:epidemiology; D014934:Wood; D001741:Black or African American
D004391:Dust