Low-cost measurement of body composition with 18O-enriched water.
Total body water (TBW) and body composition are crucial for the estimation of nutritional status in many clinical circumstances. While the measurement of TBW with 18O-enriched water is technically easier than with 2H2O, the cost of 10% 18O-enriched water can be regarded as prohibitive. The aim of this study was to prove that less enriched (i.e. 2%) and cheaper (about 25 ECU per dose per subject, i.e. $30) 18O water can be used to measure TBW. In the 41 subjects studied, isotopic equilibrium was achieved 4 hours after the isotope was administered. Plateau enrichments in urine, saliva, and plasma samples did not differ significantly between 5 and 8 hours after the dose. TBW measurements in 8 of these subjects showed no significant differences, regardless of whether 2% or 10% water was used. We conclude that accurate estimates of TBW and body composition can be obtained with low-cost, 2% 18O-enriched water.
Laboratoire de Nutrition Humaine, Centre de Recherche en Nutrition Humaine-Auvergne, Clermont-Ferrand, France.
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Vache
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Gachon
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Ferry
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Beaufrere
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Ritz
D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry / Q000379:methods; D001823:Body Composition; D001834:Body Water; D005260:Female; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D008875:Middle Aged; D010103:Oxygen Isotopes; D012016:Reference Values
D010103:Oxygen Isotopes