Genotoxicity assay of chloral hydrate and chloropicrine.
The chlorination by-products chloral hydrate and chloropicrine were assayed for genotoxicity in three short-term tests. Chloropicrine was 100-fold more potent than chloral in inducing mutations in strain TA100 of S. typhimurium (fluctuation test) and, at variance with chloral, was positive in the SOS chromotest using strain PQ37 of E. coli. On the other hand, only chloral caused a significant increase in the frequency of micronucleated erythrocytes following in vivo exposure of the amphibian Pleurodeles waltl newt larvae.
Laboratory of Genetic Toxicology, Pasteur Institute, Lille, France.
S
S
Giller
F
F
Le Curieux
L
L
Gauthier
F
F
Erb
D
D
Marzin
D000818:Animals; D002697:Chloral Hydrate / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010999:Pleurodeles; D012486:Salmonella typhimurium / Q000187:drug effects; D018508:Water Purification
D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D002697:Chloral Hydrate; C100187:chloropicrin