[Involvement of urodilatin in the hydro-electrolytic modifications induced in man by a 6 degree head-down tilt].
On 6 healthy men, we measured: 1/ the effects of 28-day -6 degrees head-down tilt on the excretion of urodilatin and 2/ the relationship between urodilatin and urinary fluid, or sodium excretion. Aliquots of the pooled 24-h urine output were used. Urodilatin increased parallel to urinary fluid or Na+ at first day of head-down tilt. Positive and statistically significant linear correlations could be established between urodilatin (and ANP) and urinary volume, or Na+ in five subjects on six. Urodilatin might participate as one of the several mechanisms of diuresis and natriuresis of first hours of head-down tilt.
Laboratoire de Physiologie de l'Environnement, GIP, Exercice, Faculté de Médecine, Lyon Grange-Blanche, France.
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Gauquelin
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Allevard
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Fagette
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Gharib
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000652:urine*; D006152:Cyclic GMP / Q000652:urine; D018475:Head-Down Tilt / Q000502:physiology*; D006801:Humans; D008297:Male; D009318:Natriuresis / Q000502:physiology*; D010446:Peptide Fragments / Q000652:urine*; D015290:Second Messenger Systems / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
D010446:Peptide Fragments; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP
Implication de l'urodilatine dans les modifications hydro-électrolytiques induites chez l'Homme par un décubitus à-6 degrees.