Comparison of rectal to intranasal administration of midazolam for premedication of children.
Sixty children aged 3 to 9, undergoing minor surgical procedures, were studied to compare 0.5 mg/kg intranasal with 0.5 mg/kg rectal midazolam as a premedication. The children were evaluated for their ability to tolerate the medication, preanesthetic sedation, and alertness after anesthesia. Both premedication routes were equally effective in sedating the children. In both groups, a significant loss of effectiveness was noted if induction of the anesthesia began more than 30 minutes after administration of the medication (p < 0.0003). Rectal midazolam was much better tolerated by the children than the intranasal route (30 versus 3, p < 0.0001). We advocate the rectal over the intranasal route for premedication with midazolam in children, and anesthetic induction should occur no more than 30 minutes after administration of premedication.
Department of Anesthesiology, Edith Wolfson Medical Center, Holon, Israel.
V
V
Khazin
S
S
Ezra
A
A
Cohen
D000281:Administration, Intranasal; D000285:Administration, Rectal; D001007:Anxiety / Q000188:drug therapy / Q000517:prevention & control; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D011229:Preanesthetic Medication / Q000009:adverse effects / Q000379:methods*
D008874:Midazolam