[Screening of multiple endocrine neoplasias type 1. Reflexions of the Study Group on Multiple Endocrine Neoplasias type 1].
The "Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1). The objectives of this group are to define diagnostic and therapeutic protocols and to carry out genetic research on NEM1. The first aim of physicians is to recognize the syndrome and to determine the appropriate screening especially into two circumstances: 1 degree In case of isolated and sporadic glandular disease -i-e-parathyroid glands, endocrine pancreas, antehypophysis, adrenal glands and neuroendocrine tumors? 2 degrees In case of very high probability of NEM 1 syndrome? This paper answers these two questions, based on the analysis of the first 150 cases collected by the GENEM 1.
Service de Chirurgie Générale et Endocrinienne, Hôpital Général, CHRU, Dijon.
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P
Cougard
A
A
Calender
B
B
Carnaille
A
A
Beckers
G
G
Cadiot
P
P
Chanson
J A
JA
Chayvialle
B
B
Conte-Devolx
M
M
Decoulx
J F
JF
Henry
D000236:Adenoma / Q000235:genetics / Q000517:prevention & control / Q000601:surgery; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000235:genetics / Q000517:prevention & control; D005260:Female; D005602:France; D015408:Gastrinoma / Q000235:genetics / Q000517:prevention & control / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery; D010903:Pituitary Gland, Anterior; D010911:Pituitary Neoplasms / Q000235:genetics / Q000517:prevention & control*
Dépistage des néoplasies endocriniennes multiples de type 1 (NEM 1). Réflexion du Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1 (GENEM 1).