Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo.
We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 microliters) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.
Federal Institute for Neurobiology, Department of Neurophysiology, Magdeburg, Germany.
G
G
Riedel
D
D
Manahan-Vaughan
A P
AP
Kozikowski
K G
KG
Reymann
D000818:Animals; D001383:Azetidinecarboxylic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D018891:Dentate Gyrus / Q000187:drug effects*; D004558:Electric Stimulation; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; C083095:azetidine-2,4-dicarboxylic acid; D001383:Azetidinecarboxylic Acid