Tetrasomy of chromosome 8 in a patient with acute myeloid leukemia.
We report a case of acute myeloid leukaemia (AML), FAB classification M2, associated with tetrasomy 8. This chromosomal aberration was detected using conventional cytogenetics and flourescent in-situ hybridization (FISH). Using FISH, the pre-treatment cells with tetrasomy 8 were disomic for chromosome 7. A small number of tetrasomy 8 cells were found post-treatment, but these were tetrasomic for chromosome 7. The significance of this is considered, and the literature regarding tetrasomy 8 in acute myeloid leukaemia is reviewed.
Cull
G M
GM
Department of Haematological Medicine, Taunton and Somerset Hospital, UK.
Howe
D J
DJ
Stack-Dunne
M
M
Phillips
M J
MJ
Johnson
S A
SA
D000328:Adult; D000782:Aneuploidy; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*