Intrathecal immune response in neonatal Flavobacterium meningosepticum meningitis.
Neonates are predisposed to serious infections such as meningitis, probably due to their immature host reaction to the pathogens. We have studied the intrathecal immune response in 2 newborns with Flavobacterium meningosepticum meningitis. They showed a significant elevation of immunoglobulin indices ( >1.10), also after the CSF had become sterile with a normalized cell count. In addition, an intrathecal increase and subsequent decrease of both C3dg and TCC (terminal complement complex) were observed in 1 patient. We conclude that immunoglobulin production and complement activation may occur in neonatal CSF.
Abrahamsen
T G
TG
Department of Pediatrics, Rikshospitalet, Oslo, Norway.
Mollnes
T E
TE
Vandvik
B
B
D000917:Antibody Formation; D003167:Complement Activation; D005417:Flavobacterium; D016905:Gram-Negative Bacterial Infections / Q000134:cerebrospinal fluid / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000276:immunology*; D013116:Spinal Cord / Q000276:immunology*
D007136:Immunoglobulins