[The effect of treatment with propafenone, metoprolol and amiodarone on lymphocyte sodium efflux and level of cAMP in serum].
The effect of long-term treatment with propafenone, metoprolol and amiodarone was studied on the activity of Na,K-adenosine triphosphatase in lymphocytes and the plasma level of cAMP in patients with ventricular arrhythmias. The investigations were carried out in 86 patients with cardiac dysrhythmias caused by coronary artery disease, hypertension, post-inflammatory and alcohol cardiomyopathy and preexcitation syndrome. Propafenone was used in treatment in 31 patients, metoprolol in 30, amiodarone in 25. The activity of of Na,K-adenosine triphosphatase in lymphocytes was estimated by the method of Heagerty et al. The plasma level of cAMP was measured radioimmunologically. Disappearance of ventricular arrhythmias after treatment was accompanied by increase in activity of of Na,K-adenosine triphosphatase and decrease in plasma level of cAMP regardless of which drug was used. Ineffective treatment did not affect both parameters.
Katedry i Kliniki Kardiologii AM, Wroclławiu.
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D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008875:Middle Aged; D011405:Propafenone / Q000627:therapeutic use; D012964:Sodium / Q000097:blood*
D000889:Anti-Arrhythmia Agents; D011405:Propafenone; D012964:Sodium; D000242:Cyclic AMP; D008790:Metoprolol; D000638:Amiodarone
Wpływ leczenia propafenonem, metoprololem oraz amiodaronem na przepływ sodu przez błony komórkowe limfocytów i stezenie cAMP w surowicy.