Protein kinase C. Seeing two domains.
Conventional protein kinase Cs have two conserved regulatory domains, C1 and C2, shared by many other membrane-interacting proteins. The structures of a C1 and a C2 domain provide insights into how they function.
Newton
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Department of Pharmacology, University of California at San Diego, La Jolla 92093-0640, USA.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D017124:Conserved Sequence; D004075:Diglycerides / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D010703:Phorbol Esters / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D011487:Protein Conformation; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism*
D004075:Diglycerides; D010703:Phorbol Esters; D010718:Phosphatidylserines; D011493:Protein Kinase C; D002118:Calcium