Identification of non-tissue-specific helix-loop-helix genes in Xenopus laevis.
We have isolated four non-tissue-specific helix-loop-helix (HLH) transcription factors from Xenopus laevis (Xl). While some are clearly orthologous to known mammalian HLH proteins, others have dramatic amino-acid differences in otherwise highly conserved protein domains. We propose that these changes arose following the tetraploidization of Xl approx. 30 Myr ago.
Shain
D H
DH
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523, USA.
Zuber
M X
MX
D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D019143:Evolution, Molecular; D018257:Helix-Loop-Helix Motifs / Q000235:genetics*; D008969:Molecular Sequence Data; D011123:Polyploidy; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C489533:TCF12 protein, Xenopus