Recurrent meningococcal septicaemia and properdin deficiency.
A 32-year-old male presented with two episodes of meningococcal septicaemia, each of which was caused by a different serogroup of Neisseria meningitidis. Examination of the alternative pathway of complement revealed the rare X-linked disorder properdin deficiency (PD). Meningococcal Infection in complement deficiency states is discussed and the unusual features of this case are highlighted.
Cunliffe
N A
NA
Department of Infectious Diseases and Tropical Medicine, (Monsall Unit) North Manchester General Hospital, Crumpsall, U.K.
Snowden
N
N
Dunbar
E M
EM
Haeney
M R
MR
D000328:Adult; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008589:Meningococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000302:isolation & purification*; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D011414:Properdin / Q000172:deficiency*
D010406:Penicillins; D011414:Properdin; D010400:Penicillin G