Equine infectious anemia virus replication is upregulated during differentiation of blood monocytes from acutely infected horses.
Equine infectious anemia virus is a lentivirus that replicates in mature tissue macrophages of horses. Ponies were infected with equine infectious anemia virus. During febrile episodes, proviral DNA was detectable, but viral mRNA was not detectable. As cultured blood monocytes from these ponies differentiated into macrophages, viral expression was upregulated. In situ hybridization confirmed that viral transcription occurred in mature macrophages.
Department of Food Animal and Equine Medicine, North Carolina State University College of Veterinary Medicine, Raleigh 27606, USA.
D C
DC
Sellon
K M
KM
Walker
K E
KE
Russell
S T
ST
Perry
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P
Covington
F J
FJ
Fuller
D000208:Acute Disease; D000818:Animals; D002454:Cell Differentiation; D004279:DNA, Viral; D004859:Equine Infectious Anemia / Q000097:blood / Q000821:virology*; D006736:Horses; D004860:Infectious Anemia Virus, Equine / Q000302:isolation & purification / Q000502:physiology*; D009000:Monocytes / Q000378:metabolism / Q000821:virology*; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D015854:Up-Regulation; D014779:Virus Replication
D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral