Resistance of Candida albicans biofilms to antifungal agents in vitro.
Biofilms formed by Candida albicans on small discs of catheter material were resistant to the action of five clinically important antifungal agents as determined by [3H]leucine incorporation and tetrazolium reduction assays. Fluconazole showed the greatest activity, and amphotericin B showed the least activity against biofilm cells. These findings were confirmed by scanning electron microscopy of the biofilms.
Laboratory of Microbiology, University of Glasgow, United Kingdom.
S P
SP
Hawser
L J
LJ
Douglas
D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans; D006801:Humans; D007930:Leucine / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013282:Stomatitis, Denture / Q000382:microbiology
D000935:Antifungal Agents; D007930:Leucine