Administration of the plasticizer di (2-ethylhexyl) phthalate alters glycoconjugate profile.
This study was undertaken to evaluate the level of glycoproteins and sialic acid in rats fed di (2-ethylhexyl)-phthalate (DEHP) in the diet for 24 weeks. Protein-bound hexose, hexosamine and sialic acid were increased in plasma and liver of rats treated with DEHP, whereas the erythrocyte membrane showed a reduction following DEHP administration. Evaluation of glycoproteins is a useful indicator of the carcinogenic process. It is suggested that profound alterations in membrane components observed in the present study may be related to the carcinogenic potential of DEHP.
Department of Biochemistry, Annamalai University, Annamalainagar.
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Selvam
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Nagini
D000818:Animals; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006595:Hexosamines / Q000097:blood / Q000378:metabolism; D006601:Hexoses / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010968:Plasticizers / Q000633:toxicity*; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000097:blood / Q000378:metabolism
D006023:Glycoproteins; D006595:Hexosamines; D006601:Hexoses; D010968:Plasticizers; D012794:Sialic Acids; D004051:Diethylhexyl Phthalate