The effect of hyperbaric oxygen on different phases of healing of ischaemic flap wounds and incisional wounds in skin.
Several studies have revealed a positive effect of treatment of ischaemic wounds and flaps with hyperbaric oxygen. We studied the effect of 100% oxygen (2.4 ATA) for 90 min daily on different phases of healing ischaemic and normal incisional wounds in rats. Hyperbaric oxygen on day 0-3 significantly increased almost all the force parameters of ischaemic flap wounds by 41-57% after 10 days of healing. On the other hand, when the treatment was continued until day 9 the positive effect on the wound healing was abolished. Furthermore, when hyperbaric oxygen was given on days 4-9 there was a tendency towards a decrease in the biomechanical parameters. Hyperbaric oxygen had no effect on the healing of normal incisional wounds.
Department of Connective Tissue Biology, University of Aarhus, Denmark.
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D000818:Animals; D001696:Biomechanical Phenomena; D006931:Hyperbaric Oxygenation; D007511:Ischemia / Q000628:therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000098:blood supply* / Q000293:injuries*; D013314:Stress, Mechanical; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*