Rethinking CD4+ T cell counts for individuals who recently seroconverted to human immunodeficiency virus.
The distribution of initial CD4+ T lymphocyte counts for individuals who have recently seroconverted to human immunodeficiency virus (HIV) is broad. We review major articles describing CD4 cell counts shortly after documented HIV infection and discuss both the possible sources of variability in these studies and the clinical importance of recognizing that even recently infected patients may have low CD4 cell counts and thus will require therapeutic intervention with antiretroviral agents or prophylactic antibiotics.
Department of Internal Medicine, Naval Medical Center, San Diego, California, USA.
P J
PJ
Weiss
M R
MR
Wallace
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D006679:HIV Seropositivity / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents