Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members.
Department of Molecular Biology, Faculty of Science, Nagoya University, Japan.
K
K
Yamaguchi
K
K
Shirakabe
H
H
Shibuya
K
K
Irie
I
I
Oishi
N
N
Ueno
T
T
Taniguchi
E
E
Nishida
K
K
Matsumoto
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D002460:Cell Line; D003001:Cloning, Molecular; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D020930:MAP Kinase Kinase Kinases; D051379:Mice; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011506:Proteins / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015398:Signal Transduction; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D000099151:MAP Kinase Kinase Kinase 7
D019485:Bone Morphogenetic Proteins; D004815:Epidermal Growth Factor; D020930:MAP Kinase Kinase Kinases; D017346:Protein Serine-Threonine Kinases; D011506:Proteins; D016212:Transforming Growth Factor beta; D000099151:MAP Kinase Kinase Kinase 7