Efficacy of ICAM-1 antisense oligonucleotide in pancreatic islet transplantation.
Significant islet allograft prolongation was achieved by ICAM-1/LFA-1 blockade. ICAM-1 antisense oligonucleotide IP-3082 was effective in improving islet function as well as prolonging graft survival.
Katz
S M
SM
University of Texas Medical School, Houston 77030, USA.
Browne
B
B
Phan
T
T
Wang
M E
ME
Bennett
C F
CF
Stepkowski
S M
SM
Kahan
B D
BD
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D006085:Graft Survival; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology*; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000379:methods* / Q000502:physiology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D001786:Blood Glucose; D016169:Lymphocyte Function-Associated Antigen-1; D016376:Oligonucleotides, Antisense; D018799:Intercellular Adhesion Molecule-1