Pharmacokinetics of ampicillin administered intravenously and intraosseously to kittens.
An aqueous solution of ampicillin sodium (100 mg ml-1) was administered intravenously and intraosseously to six kitten at 50 mg kg-1 in a crossover study. Jugular vein blood samples were taken at intervals up to eight hours after treatment and the serum ampicillin concentration-time data, derived from a microbiological assay, were analysed pharmacokinetically. The disposition kinetics of ampicillin administered by the two routes were very similar. The mean elimination half-life (t1/2 beta), the area-derived volume of distribution (Varea) and the total body clearance (ClB) values after the intravenous and intraosseous treatment were 86.3 and 79.0 minutes, 0.9 and 0.8 litre kg-1 and 7.3 and 7.6 ml min-1 kg-1, respectively. No side-effects related to the intraosseous administration of the drug were observed.
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
R
R
Goldstein
E
E
Lavy
M
M
Shem-Tov
A
A
Glickman
H
H
Bark
G
G
Ziv
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001842:Bone and Bones; D002415:Cats; D018592:Cross-Over Studies; D005260:Female; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D010406:Penicillins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D010406:Penicillins; D000667:Ampicillin