HLA-B27 negative ankylosing spondylitis in a father and a son.
Only 5% of AS patients are B27 negative. We describe two cases of HLA-B27 negative AS in a father and a son who both developed clinical and radiological features characteristic of AS. Tissue typing for HLA-A,-B,-C was performed in all 1.degree family members except for the father who died in 1990. All family members possessed B40. HLA-B40 may contribute to an increased susceptibility for AS not only in B27 positive individuals but also in B27 negative cases.
Skomsvoll
J F
JF
Department of Rheumatology, University Hospital of Trondheim, Norway.
Ostensen
M
M
Romberg
O
O
Anda
S
S
D000328:Adult; D000368:Aged; D001175:Arthrography; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D010388:Pelvis / Q000000981:diagnostic imaging; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000235:genetics* / Q000276:immunology*
D015796:HLA-B27 Antigen