[Translocation t(6;9;8)(p23;q34;q22) in acute myeloid leukemia: Contribution of fluorescence in situ hybridization].
A complex translocation involving chromosome 6, 8 and 9 [t(6;9;8)(p23;q34;q22)] associated with other structural and numerical abnormalities was observed on bone marrow karyotype of a woman suffering with acute myeloblastic leukemia (AML2). Fluorescence in situ hybridization agreed with the conventional cytogenetic interpretation by showing that a part of chromosome 6 short arm was inserted on the rearranged chromosome 9 resulting in the t (6;9) usually encountered in AML.
Laboratoire de Cytogénétique, Hôpital Saint-Antoine, Paris, France.
J
J
van den Akker
C
C
Pérot
M F
MF
Portnoï
L
L
Philizot
J M
JM
Dupont
J P
JP
Laporte
J L
JL
Taillemite
D000208:Acute Disease; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic
Translocation t(6;9;8)(p23;q34;q22) dans une leucémie aiguë myéloïde: apport de l'hybridation in situ fluorescente.