A novel TaqI/DQA RFLP associated with HLA-DR9, DQ9 (DQA1*0302).
A new TaqI/DQA restriction fragment length polymorphism (RFLP) has been found in two Spanish Caucasoid individuals. The novel polymorphic fragment has a relative mobility of 4.2 kb and is associated with an HLA-A2,Cw*1401,B51,DR9,DR53,DQ9 haplotype. Nucleotide sequence analysis indicates that individuals showing this RFLP pattern do not carry a new DQA1 allele, but that (DQA1*0302) commonly observed in DR9,DQ9 haplotypes. The new RFLP seems to be a locally restricted marker of uncertain origin.
Vilches
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Servicio de Immunología, Hospital Puerto de Hierro, Madrid, Spain.
de Pablo
R
R
Solís
R
R
Martín
R
R
Herrero
M J
MJ
Moreno
M E
ME
Kreisler
M
M
D000483:Alleles; D001483:Base Sequence; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D013030:Spain; D044465:White People / Q000235:genetics
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C038988:HLA-DR9 antigen; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases