Microvascular disease and anastomotic dehiscence in the colon.
Platelet-derived serotonin released in response to tissue manipulation during surgery may contribute to mesenteric arterial vasospasm leading to postoperative anastomotic leakage after colorectal resection. Organ bath experiments were used to demonstrate the efficacy of naftidrofuryl fumarate (NFT) to oppose serotonin-induced vasoconstriction of human mesenteric arteries. Cumulative dose-response curves were derived with and without NFT at 10(-9) and 10(-6) mol/l concentrations. The difference in maximal contractility between the three sets of curves (n = 8 for each) was significant (P < 0.0001). Sensitivity to serotonin in each of the three curves was measured by calculating the concentration for half-maximal response; differences were again significant (P < 0.0001). NFT reduced serotonin-induced contractility in a dose-dependent fashion in rings of human mesenteric arteries in vitro. This suggests a possible role for NFT in reducing mesenteric vasospasm in colorectal surgery.
Department of Surgery, Charing Cross Hospital, London, UK.
A
A
Fawcett
R
R
Vashisht
A
A
Shankar
P M
PM
Dawson
M K
MK
O'Malley
D M
DM
Nott
R G
RG
Springall
D000714:Anastomosis, Surgical; D003106:Colon / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017537:Mesenteric Artery, Inferior / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009257:Nafronyl / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013529:Surgical Wound Dehiscence
D012702:Serotonin Antagonists; D009257:Nafronyl