Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis.
Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs of increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunophenotypic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.
Lowichik
A
A
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA.
Bernini
J C
JC
Tonk
V
V
Ansari
M Q
MQ
Rollins
N K
NK
Winick
N J
NJ
Timmons
C F
CF
D000293:Adolescent; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002051:Burkitt Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012008:Recurrence; D013997:Time Factors; D014057:Tomography, X-Ray Computed