[An experimental study of the effect of vanadium on enzyme indices in chronic oral exposure].
Changes in selected enzyme parameters were followed in a one year-long toxicologic experiment on albino rat males given vanadium by mouth at either of two dosages: 0.005 mg/kg b.w., which is the equivalent of the regulated level for 1st category drinking water, or 0.01 mg/kg, i.e., twice the safety standard. The endpoints measured included: free sulfhydryl groups in blood serum, heart, and liver; cholinesterase and creatine kinase activities in blood serum; catalase activity in blood; and cytochrome oxidase activity in liver and heart. Chronic oral exposures to vanadium 0.01 mg/kg and, to a lesser extent, 0.005 mg/kg were observed to produce disturbances in redox processes and tissue respiration. The evidence from this study should be taken into consideration when regulating vanadium levels in drinking water from a hygiene standpoint.
Vodichenska
Ts
Ts
Bŭdeva
V
V
D000284:Administration, Oral; D000818:Animals; D002374:Catalase / Q000097:blood / Q000187:drug effects*; D002802:Cholinesterases / Q000097:blood / Q000187:drug effects*; D003402:Creatine Kinase / Q000097:blood / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D003576:Electron Transport Complex IV / Q000187:drug effects* / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013997:Time Factors; D014639:Vanadium / Q000008:administration & dosage / Q000633:toxicity*
D013438:Sulfhydryl Compounds; D014639:Vanadium; D002374:Catalase; D003576:Electron Transport Complex IV; D003402:Creatine Kinase; D002802:Cholinesterases
Eksperimentalno prouchvane na vliianieto na vanadiia vŭrkhu enzimni pokazateli pri khronichno oralno vŭzdeĭstvie.