Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q.
The Clc2 gene of the mouse codes for the ubiquitously expressed chloride channel ClC-2, a member of a family of at least seven voltage gated chloride channels, some of which are implicated in hereditary diseases. Using a mouse interspecies back-cross panel, we have mapped Clc2 to Chr 16, proximal to the somatostatin gene Smst, extending a region of documented conserved synteny to human Chr 3q.
Developmental Biology Unit, University of Bielefeld, Federal Republic of Germany.
A
A
Lengeling
M
M
Gronemeier
M
M
Ronsiek
A
A
Thiemann
T J
TJ
Jentsch
H
H
Jockusch
D000818:Animals; D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels / Q000235:genetics*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL
D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels; C000715428:Clcn2 protein, mouse