[Mechanisms for inactivation of tumor suppressor genes].
Tumor suppressor genes are inactivated by various mechanisms. Since a mutant allele of a tumor suppressor gene is recessive for cellular malignant transformation, mutation is heritable and germ line mutations of tumor suppressor genes such as retinoblastoma gene and p53 gene are well characterized. In the process of loss-of-function of a tumor suppressor gene, chromosome type of mutations are often involved, which results in tumor specific loss of heterozygosity (LOH) on a specific chromosome. Somatic mutations of the p53 gene in a variety of tumors were extensively studied and a huge data base is now available. Mutation spectra of the p53 gene in various tumors are different each other and to be used as a molecular indicator of carcinogens involved in each type of tumor.
Ishizaki
K
K
Aichi Cancer Center Research Institute, Laboratory of Experimental Radiology.
D015972:Gene Expression Regulation, Neoplastic; D016161:Genes, Retinoblastoma / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D009154:Mutation