Effect of varying surface patterns on antibiotic elution from antibiotic-loaded bone cement.
In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.
Masri
B A
BA
Department of Orthopaedics, Vancouver Hospital and Health Sciences Centre, British Columbia, Canada.
Duncan
C P
CP
Beauchamp
C P
CP
Paris
N J
NJ
Arntorp
J
J
D019072:Antibiotic Prophylaxis; D001843:Bone Cements / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007595:Joint Prosthesis; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D014031:Tobramycin / Q000008:administration & dosage* / Q000737:chemistry
D001843:Bone Cements; D014031:Tobramycin