Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys.
PET imaging studies with 4-[18F]fluoro-L-m-tyrosine (FMT) in normal macaca monkeys showed selective accumulations of radioactivity in the striatum with time. In monkeys rendered hemiparkinsonian by intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), FMT uptake was eliminated in the lesioned striatum. FMT-PET studies were able to detect dopaminergic terminals in both normal and hemiparkinsonian monkeys, and clearly showed a reduction in aromatic L-amino acid decarboxylase (AAAD) activities in the MPTP-lesioned striatum. These results show that FMT is promising as a PET tracer for the evaluation of central dopaminergic systems in parkinsonism.
Department of Neurosurgery and Nuclear Medicine, Gunma University School of Medicine, Japan.
N
N
Hayase
K
K
Tomiyoshi
K
K
Watanabe
S
S
Horikoshi
T
T
Shibasaki
C
C
Ohye
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D000697:Central Nervous System Stimulants / Q000493:pharmacokinetics; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D008251:Macaca; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000378:metabolism; D012016:Reference Values; D014055:Tomography, Emission-Computed / Q000379:methods; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D000697:Central Nervous System Stimulants; D005462:Fluorine Radioisotopes; C001245:3-fluorotyrosine; D014443:Tyrosine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine