[Morphological characteristics of reparative process in tuberculous inflammation].
The morphological analysis of the reparative process in the involvement foci and adjacent pulmonary tissue in patients with pulmonary tuberculosis and experimental animals during intensive focal resolution has revealed a change in the cellular composition: epithelioid cells are replaced by macrophages, T-lymphocytes SD8 (suppressors) by those CD4 (helpers); actively synthesizing fibroblasts and vascular endothelium appear in the area of specific inflammation instead of the cells that have a decreased collagen-forming function. The employment of various methods for stimulation of cellular reactions (lasers, electromagnetic irradiation of the mm range - MM waves, the complex of cytokines) leukinferon enables one to alter the qualitative and quantitative cellular composition of granulomas, the rate of metabolic processes and the differentiation of cells, as well as to examine the regularities of reparative reactions more effectively and more purposefully. The perfocally adjacent pulmonary tissue wherein the diseased parenchyma and stroma recover has been ascertained to be also involved into the reparative process.
Erokhin
V V
VV
Gedymin
L E
LE
Lepekha
L N
LN
Nikolaeva
G M
GM
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008264:Macrophages; D051379:Mice; D008808:Mice, Inbred CBA; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
D000995:Antitubercular Agents; D003094:Collagen
Morfologicheskaia kharakteristika reparativnogo protsessa pri tuberkuleznom vospalenii.