Ampicillin plus ciprofloxacin therapy of experimental endocarditis caused by multidrug-resistant Enterococcus faecium.
The combination of ampicillin and ciprofloxacin displayed bactericidal in-vitro activity against two strains of Enterococcus faecium which were highly resistant to ampicillin, vancomycin, and aminoglycosides. This antibiotic combination was used to treat rabbits with experimental endocarditis caused by these strains. Although a significant decrease in vegetation bacterial counts occurred with one strain, the degree of killing did not approach that of penicillin with an aminoglycoside against susceptible enterococci.
Department of Medicine (111E), Department of Veterans Affairs Medical Center, Brooklyn, New York 11209, USA.
D
D
Landman
J M
JM
Quale
N
N
Mobarakai
M M
MM
Zaman
D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D016984:Enterococcus faecium; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007668:Kidney / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000627:therapeutic use; D011817:Rabbits; D013154:Spleen / Q000382:microbiology
D000890:Anti-Infective Agents; D010406:Penicillins; D002939:Ciprofloxacin; D000667:Ampicillin