[Desensitization of the nicotinic acetylcholine receptor].
In biological membranes, ionic channels act speeding up ion movements. Each ionic channel is excited by a specific stimulus (i.e. electric, mechanical, chemical, etc.). Chemically activated ionic channels (CAIC), such as the nicotinic acetylcholine receptor (nAChR), suffer desensitization when the receptor site is still occupied by the agonist molecule. The desensitized CAIC is a non functional channel state regarded as a particular case of receptors rundown. CAIC desensitization only involve reduced activity and not their membrane elimination. Desensitization is important to control synaptic transmission and the development of the nervous system. In this review we discuss results related to its production, modulation and some aspects associated to models that consider it. Finally, an approach combining molecular biology and electrophysiology techniques to understand desensitization and its importance in biological systems is presented.
Laboratorio de Fisiología y Biofísica de la Sinapsis, Facultad de Ciencias, Caracas, Venezuela.
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Quiñonez
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Rojas
D000818:Animals; D002024:Bufo marinus; D004594:Electrophysiology; D007473:Ion Channels / Q000502:physiology*; D008956:Models, Chemical; D018733:Nicotinic Antagonists; D013696:Temperature
D007473:Ion Channels; D018733:Nicotinic Antagonists
La desensibilizacion del receptor nicotinico para la acetilcolina.