Insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in Taiwanese women during normal pregnancy.
Circulating levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-1 (IGFBP-1) in Taiwanese women during normal pregnancy were investigated. Three hundred and eighty-five pregnant women at various gestational ages and 30 nonpregnant females were recruited into the study. Serum concentrations of IGF-I and IGFBP-1 were determined by immunoradiometric assay (IRMA) and radioimmunoassay (RIA). Maternal serum levels of IGF-I increased as pregnancy progressed. Circulating IGF-I levels in women during the first trimester of pregnancy were higher than those in nonpregnant females. Serum levels of IGFBP-1 rose rapidly before 12 weeks of gestation and remained high until term. Serum IGFBP-1 levels in pregnant women during the first trimester were significantly higher than those in nonpregnant females. However, there was no difference in maternal serum IGFBP-1 levels between the second and the third trimester of pregnancy. It is concluded that serum IGF-I levels during pregnancy may be regulated by various classes of IGF-binding proteins other than IGFBP-1.
Department of Obstetrics and Gynecology, Chang-Gung Medical School, Chang-Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan, ROC.
H S
HS
Wang
B J
BJ
Cheng
Y K
YK
Soong
D001724:Birth Weight; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011247:Pregnancy / Q000097:blood*; D011863:Radioimmunoassay; D012016:Reference Values; D013624:Taiwan
D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I