Congenital streptococcal toxic shock syndrome with absence of antibodies against streptococcal pyrogenic exotoxins.
Congenital infection with group A beta-hemolytic streptococcus was complicated by toxic shock syndrome in a neonate. We hypothesize that the severity of the clinical syndrome was related to the streptococcal pyrogenic exotoxin in the absence of corresponding antibodies. The outcome may have been favorably influenced by the antibodies to streptococcal pyrogenic exotoxin present in the immunoglobulins given as treatment.
Mahieu
L M
LM
Department of Pediatrics, University of Antwerp, Belgium.
Holm
S E
SE
Goossens
H J
HJ
Van Acker
K J
KJ
D000907:Antibodies, Bacterial; D005098:Exotoxins / Q000506:poisoning*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use; D007275:Injections, Intravenous; D008297:Male; D011749:Pyrogens / Q000506:poisoning*; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000209:etiology*; D013290:Streptococcal Infections / Q000151:congenital* / Q000188:drug therapy / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000302:isolation & purification*
D000907:Antibodies, Bacterial; D005098:Exotoxins; D007136:Immunoglobulins; D011749:Pyrogens