The D-1 dopamine receptor: past, present and future an idiosyncratic review.
1. Key events in the experimental investigation of the D-1 dopamine receptor are reviewed. 2. The efficacy of D-1 receptor agonists in the treatment of experimental parkinsonism in MPTP-treated primates is demonstrated. The diminished dyskinetic liability of D-1 agonists is discussed. 3. The significance of the dopa-induced dyskinesias is discussed from the perspective of deterministic chaos. The unpredictibility and irreproducibility of dyskinetic movements is highlighted and compared with features of the logistic equation. 4. The authors propose that the dopa-induced dyskinesias should be considered to be a manifestation of a chaotic process within the basal ganglia. The loss of the dopaminergic innervation and the subsequent repeated exposure to dopamine (derived from the exogenous dopa administered to the subjects) alters the response properties of the basal ganglia circuitry so that stimulation of dopamine receptors now elicits the dyskinetic movements.
Kebabian
J W
JW
Research Biochemicals International, Natick, MA, USA.
Blanchet
P J
PJ
Bedard
P
P
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D009069:Movement Disorders / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000187:drug effects* / Q000502:physiology*
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1