A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2).
Department of Chemistry, Searle Research and Development, Skokie, IL 60077, USA.
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Huff
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Collins
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Kramer
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Seibert
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Koboldt
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Gregory
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Isakson
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D051379:Mice; D009578:Nitrobenzenes / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013449:Sulfonamides / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D009578:Nitrobenzenes; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D011451:Prostaglandin-Endoperoxide Synthases