Influence of metronidazole and tamoxifen in a case of otherwise untreated ulcerous breast carcinoma.
A 78-year-old patient with an ulcerous, purulent, exophytic fist-sized breast carcinoma (FIGO IVd) and a pulmonary metastasis who refused radiation, chemotherapy and operation, was treated with oral tamoxifen and metronidazole daily and with local antiseptics. After two months she was pain-free without analgesics. After eight months the exophytic part of the tumor had completely gone. One year after the beginning of treatment, during which she had led a normal life, metronidazole was withdrawn due to neuropathy, and the wound worsened within a few days. One month later opioids were required to treat tumor-induced pain. Two months later the patient died. The surprisingly long survival with good quality-of-life may indicate important effects of metronidazole combined with tamoxifen in the treatment of ulcerous breast cancer.
Krankenhaus der Barmherzigen Brüder Gynäkologische Station, München, Germany.
F
F
Heirler
S
S
de la Motte
W
W
Popp
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D013629:Tamoxifen / Q000008:administration & dosage; D014456:Ulcer / Q000188:drug therapy / Q000473:pathology
D013629:Tamoxifen; D008795:Metronidazole