[123I-MIBG myocardial SPECT in two patients with familial amyloid polyneuropathy].
201T1C1 SPECT and 123I-MIBG SPECT were performed in two patients with familial amyloid polyneuropathy (FAP). Both patients showed normal accumulation of 201T1C1 and no accumulation of 123I-MIBG in the myocardium at the early and delayed images. These results indicate that the patient with FAP-related myocardial change accompanies sympathetic nerve dysfunction. The dysfunction is supposed to be caused by disturbance of re-uptake of MIBG by the terminal ending of the sympathetic nerve (uptake-1) through the amyloid-deposited connective tissue.
Department of Radiology, Shinshu University School of Medicine.
A
A
Itoh
S
S
Sone
T
T
Kasuga
F
F
Nakanishi
M
M
Hasegawa
K
K
Oguchi
K
K
Yokota
M
M
Tanaka
R
R
Kai
D019797:3-Iodobenzylguanidine; D000328:Adult; D017772:Amyloid Neuropathies / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine