Absence of evidence for mutagenicity of alcoholic beverages: an analysis of hprt mutant frequencies in 153 normal humans.
A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors were classified into four groups, including total abstainers (n = 18); those who consumed less than the Royal College of Physicians guideline (men, 21 units; women, 14 units) (n = 113); those who consumed more than the guideline value (n = 12); and designated alcohol-dependent subjects (n = 10). No significant difference in mutant frequency between the four groups was found, nor was an overall correlation between alcohol consumption and mutant frequency seen.
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.
J
J
Cole
M H
MH
Green
D000079:Acetaldehyde / Q000633:toxicity; D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics; D000434:Alcoholic Beverages / Q000633:toxicity*; D000437:Alcoholism / Q000235:genetics; D001711:Biotransformation; D000431:Ethanol / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008297:Male; D009152:Mutagenicity Tests; D012907:Smoking / Q000235:genetics; D013695:Temperance
D000431:Ethanol; D007041:Hypoxanthine Phosphoribosyltransferase; D000079:Acetaldehyde