CD46-mediated measles virus entry: a first key to host-range specificity.
Humans are the sole natural host of measles virus. The identification of CD46 as a virus receptor and of the involvement of moesin sheds some light on the molecular events occurring during virus entry into the cell. Knowledge of the key role of CD46 paves the way to creating transgenic mice sensitive to measles virus infection.
Laboratoire Immunité et Infections Virales, I.V.M.C. CNRS-UCBL UMR30, Faculté de Médecine Alexis Carrel, Lyon, France.
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Gerlier
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Varior-Krishnan
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Devaux
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D004195:Disease Models, Animal; D006389:Hemagglutinins, Viral / Q000378:metabolism*; D006801:Humans; D008459:Measles virus / Q000472:pathogenicity / Q000502:physiology* / Q000648:ultrastructure; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008840:Microfilament Proteins; D011506:Proteins / Q000378:metabolism; D013045:Species Specificity; D014760:Viral Fusion Proteins / Q000378:metabolism; D014779:Virus Replication
D015703:Antigens, CD; C497857:CD46 protein, human; D006389:Hemagglutinins, Viral; C497859:Mcp protein, mouse; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; D011506:Proteins; D014760:Viral Fusion Proteins; C071058:moesin