[Studies on thromboxane B2 level in nasal lavage fluid after antigen challenge in patients with allergic rhinitis and guinea pig models].
Thromboxane A2 (TxA2) seems to play an important role in bronchial constriction and hypersensitivity in asthmatics. To study the role of TxA2 in allergic rhinitis, we investigated the levels of thromboxane B2 (TxB2), a stable metabolite of TxA2, in nasal lavage fluid from patients with allergic rhinitis and from actively sensitized guinea pigs after antigen challenge by radioimmunoassay (RIA). There was a significant (p < 0.05) rise in TxB2 levels soon after antigen challenge in nasal lavage fluid from both patients (36.4 +/- 7.5 pg/ml, mean +/- SE) and models (55.6 +/- 21.8 pg/ml). In some of the patients and models, there was an dual rise in TxB2 in the 10 hours after antigen challenge. There was a significant (p < 0.03) correlation between the patients whose levels of TxB2 were re-elevated and them whose nasal airway resistance showed dual rises. These results suggest that TxA2 may contribute to the nasal obstruction in later phase in allergic rhinitis.
Narita
S
S
Department of Otolaryngology, Sapporo Medical University.
Asakura
K
K
Shirasaki
H
H
Kojima
T
T
Kataura
A
A
D000328:Adult; D000818:Animals; D000941:Antigens / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D017817:Nasal Lavage Fluid / Q000276:immunology* / Q000382:microbiology; D015508:Nasal Obstruction / Q000209:etiology; D011863:Radioimmunoassay; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000378:metabolism; D013928:Thromboxane A2 / Q000502:physiology; D013929:Thromboxane B2 / Q000032:analysis*
D000941:Antigens; D013929:Thromboxane B2; D013928:Thromboxane A2