Activity of 9-acridanone-hydrazone drugs detected at the pre-postural phase, in the experimental schistosomiasis mansoni.
The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.
Pereira
L H
LH
Departamento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Coelho
P M
PM
Costa
J O
JO
de Mello
R T
RT
D000166:Acridines / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002428:Cebus; D005260:Female; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D012556:Schistosomicides / Q000494:pharmacology* / Q000627:therapeutic use
D000166:Acridines; D012556:Schistosomicides; C062730:Ro 15-5458