An investigation of the pharmacokinetics and autoinduction of rifabutin metabolism in mice treated with 10 mg/kg/day six times a week for 8 weeks.
Plasma, lung and spleen concentrations of rifabutin have been measured in mice after single and multiple oral administrations of the drug. Rifabutin concentrations in spleen were similar to those measured in plasma, whereas concentrations in lung were higher. No significant autoinduction of rifabutin metabolism was observed.
Pharmacia-Farmitalia Carlo Erba, Milan, Italy.
M
M
Strolin Benedetti
E
E
Pianezzola
G
G
Brianceschi
D
D
Jabes
C
C
Della Bruna
M
M
Rocchetti
I
I
Poggesi
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D008168:Lung / Q000378:metabolism; D051379:Mice; D017828:Rifabutin / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D017828:Rifabutin