HML-1, a novel integrin made of the beta 7 chain and of a distinctive alpha chain, exerts an accessory function in the activation of human IEL via the CD3-TCR pathway.
INSERM U132, Hôpital Necker-Enfants Malades, Paris.
B
B
Bègue
S
S
Sarnacki
F
F
le Deist
H
H
Buc
J
J
Gagnon
T
T
Méo
N
N
Cerf-Bensussan
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D039001:Integrin alpha Chains; D039641:Integrin beta Chains; D016023:Integrins / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology*; D008213:Lymphocyte Activation; D010716:Phosphatidylinositols / Q000378:metabolism; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D039001:Integrin alpha Chains; D039641:Integrin beta Chains; D016023:Integrins; D010716:Phosphatidylinositols; D017260:Receptor-CD3 Complex, Antigen, T-Cell; C091367:alpha E integrins; C070709:integrin alphaEbeta7; C091368:integrin beta7; D002118:Calcium