Remote cortical dysfunction as a possible cause of subcortical neglect? A regional cerebral blood flow study.
Cortical remote effects of right deep-seated lesions were studied with two cerebral blood flow measurement methods (two-dimensional xenon-133 inhalation and 99mTc HMPAO SPECT) in a population of 13 right-handed stroke patients. A neuropsychological battery of tests suitable for assessment of possible visual neglect was performed. Neglect was present in 7 cases. A regional cortical hypoperfusion was observed in all patients. However, in neglect patients it was more extended and involved the right inferior parietal region suggesting a causal relationship between cortical dysfunction and neuropsychological deficit. This finding supports the model attributing neglect to a unilateral attention-arousal defect in a cortico-limbic-reticular loop.
Hôpital Universitaire Brugmann, Service de Revalidation Neurologique, Bruxelles, Belgique.
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C
Hublet
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Demeurisse
J
J
Paternot
C
C
Colson
A
A
Capon
D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D008032:Limbic System / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000000981:diagnostic imaging; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D010091:Oximes; D011597:Psychomotor Performance / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D012154:Reticular Formation / Q000098:blood supply / Q000000981:diagnostic imaging; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
D015609:Organotechnetium Compounds; D010091:Oximes; D014980:Xenon Radioisotopes; D019690:Technetium Tc 99m Exametazime