[CD5-negative B-cell chronic lymphocytic leukemia (B-CLL) associated with massive splenomegaly and without lymphadenopathy].
A 39-year-old male was referred to our hospital in June, 1993, because of leukocytosis. Physical examinations showed massive splenomegaly without any lymphadenopathy. The white blood cell count was 13,800/microliters with 87% morphologically mature lymphocytes. Bone marrow aspirate revealed hypercellularity with 67% lymphocytes morphologically similar to peripheral lymphocytes. The lymphocytes displayed monoclonal rearrangements of immunoglobulin genes and the phenotype of CD5-CD19+CD20+ CD21+ and Smlg+. Splenectomy was effective against neutropenia and thromboytopenia. The clinical and laboratory findings of this case were unusual compared to those of typical B-CLL in massive splenomegaly, no lymphadenopathy and CD5-phenotype, suggesting the heterogeneity of B-CLL.
First Department of Internal Medicine, School of Medicine, Ehime University.
T
T
Yamada
H
H
Ninomiya
T
T
Horiuchi
K
K
Takada
T
T
Hato
K
K
Yamauchi
M
M
Yasukawa
S
S
Fujita
D000328:Adult; D018956:CD5 Antigens / Q000276:immunology*; D015321:Gene Rearrangement; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008206:Lymphatic Diseases; D008297:Male; D013163:Splenomegaly / Q000150:complications* / Q000601:surgery
D018956:CD5 Antigens; D007136:Immunoglobulins