Potential intraembryonic hemogenic sites at pre-liver stages in the mouse.
In the course of a previous experimental study on the early development of the mouse embryo hemopoietic system, we found that, at the 10-25 pairs of somite stages, the para-aortic splanchnopleure contains hemopoietic progenitors. Trying to discover a structural basis for this potentiality, we have looked for cytological signs of hemopoiesis in the embryo proper between 8.5 and 12 days post-coitum, i.e. prior to full-blown fetal liver hemopoiesis. Two suggestive findings are reported: (1) intra-arterial hemopoietic cells aggregates are present in the omphalomesenteric and umbilical arteries and to a lesser degree in the dorsal aorta; (2) cells groups resembling yolk sac blood islands are observed in the mesentery. The intra-arterial aggregates are strikingly similar to the intra-aortic clusters of avian embryos. These cytological aspects provide the anatomical basis underlying recent functional data that revealed the hemogenic capacity of the para-aortic splanchnopleure.
Garcia-Porrero
J A
JA
Departamento de Anatomia y Biologia Cellular, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.
Godin
I E
IE
Dieterlen-Lièvre
F
F
D000818:Animals; D001158:Arteries / Q000196:embryology; D001808:Blood Vessels / Q000196:embryology; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology*; D005314:Embryonic and Fetal Development; D006410:Hematopoiesis; D008099:Liver / Q000196:embryology*; D008643:Mesentery / Q000196:embryology; D051379:Mice / Q000196:embryology*; D008807:Mice, Inbred BALB C; D013152:Splanchnic Circulation