Modulation of idiotypic and antiidiotypic immunoglobulin G responses in an immune thrombocytopenic purpura patient as a consequence of extracorporeal protein A immunoadsorption.
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by the presence of antiplatelet antibody which sensitizes platelets resulting in their clearance by the reticuloendothelial system. Extracorporeal protein A immunoadsorption has been demonstrated to be of benefit in the treatment of this autoimmune disorder. In the present study, a patient with underlying systemic lupus erythematosus (SLE) presented with ITP. The patient received 14 immunoadsorption treatments and responded to therapy. During the course of immunoadsorption treatments, there was a decline in circulating immune complex (CIC) levels, antinuclear antibody (ANA) levels, and antiplatelet IgG antibody levels. In addition, elevated levels of antiidiotypic IgG antibody detected before initiation of therapy were significantly reduced during the course of immunoadsorption treatments. This study suggests that specific autoimmune idiotypic IgG antibody and corresponding antiidiotypic IgG antibody responses may be modulated in association with extracorporeal immunoadsorption employing protein A/silica columns.
IMRE Corporation, Seattle, WA 98109, USA.
J P
JP
Balint
S K
SK
Cochran
F R
FR
Jones
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism; D000974:Antibodies, Antinuclear / Q000276:immunology / Q000378:metabolism; D000936:Antigen-Antibody Complex / Q000276:immunology; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007163:Immunosorbent Techniques; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D013205:Staphylococcal Protein A / Q000378:metabolism*
D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D013205:Staphylococcal Protein A