Regional cortical anatomy and clozapine response in refractory schizophrenia.
Regional measures of cortical sulcal and ventricular enlargement on computed tomography scan were studied in a clinical sample of patients treated with clozapine. Cortical sulci were significantly enlarged in clozapine nonresponders compared to responders. The Clinical Global Impressions score at discharge was related to the size of the posterior frontal and lateral temporal sulci, with large sulci predicting a poorer response to clozapine treatment.
Honer
W G
WG
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Smith
G N
GN
Lapointe
J S
JS
MacEwan
G W
GW
Kopala
L
L
Altman
S
S
D000328:Adult; D014150:Antipsychotic Agents; D001921:Brain / Q000473:pathology*; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents; D003024:Clozapine