Activity of 9-acridanone-hydrazone drugs detected at the pre-postural phase, in the experimental schistosomiasis mansoni.
The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.
Departamento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
L H
LH
Pereira
P M
PM
Coelho
J O
JO
Costa
R T
RT
de Mello
D000166:Acridines / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002428:Cebus; D005260:Female; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D012556:Schistosomicides / Q000494:pharmacology* / Q000627:therapeutic use
D000166:Acridines; D012556:Schistosomicides; C062730:Ro 15-5458