Induction of artificial endometrial cycles with oestradiol implants and injectable progesterone: establishment of a viable pregnancy in a woman with 17-alpha-hydroxylase deficiency.
Repeated attempts with oral oestrogens and injectable progesterone failed to induce secretory endometrium in a woman with 17-alpha-hydroxylase deficiency. The insertion of s.c. 17-beta-oestradiol implants dramatically improved the endometrial response and enabled the establishment of endometrial maturation. A viable pregnancy was achieved after the uterine transfer of in-vitro fertilized donated eggs.
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.
I
I
Ben-Nun
A
A
Siegal
A
A
Shulman
Y
Y
Ghetler
H
H
Kaneti
B
B
Lunenfeld
Y
Y
Beyth
M
M
Fejgin
D000312:Adrenal Hyperplasia, Congenital; D000328:Adult; D004343:Drug Implants; D004624:Embryo Transfer; D004717:Endometrium / Q000503:physiopathology*; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D017359:HELLP Syndrome; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D011225:Pre-Eclampsia; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use*
D004343:Drug Implants; D011374:Progesterone; D004958:Estradiol