Visualisation of mass transport of small organic molecules and metal ions through articular cartilage by magnetic resonance imaging.
Magnetic resonance imaging of water has been used to visualise the migration of three paramagnetic species, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (4-hydroxy-TEMPO, 1), Cu2+ ions, and copper ethylenediamine-tetraacetate (CuEDTA, 2) through cartilage on the femoral condyle of the chicken knee. The migration of copper ions is dominated by strong binding with the cartilage. In contrast, both 1 and 2 bind weakly, and their diffusion can be followed as a progressive wave through the cartilage and subsequently into the trabecular bone structure.
Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge School for Clinical Medicine, UK.
A E
AE
Fischer
T A
TA
Carpenter
J A
JA
Tyler
L D
LD
Hall
D000818:Animals; D001692:Biological Transport; D002358:Cartilage, Articular / Q000033:anatomy & histology* / Q000378:metabolism*; D002645:Chickens; D003300:Copper / Q000378:metabolism*; D003497:Cyclic N-Oxides / Q000378:metabolism; D004492:Edetic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D013113:Spin Labels
D003497:Cyclic N-Oxides; D013113:Spin Labels; D003300:Copper; D004492:Edetic Acid; C001803:tempol