Native-like and structurally characterized designed alpha-helical bundles.
A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.
Betz
S F
SF
DuPont Merck Pharmaceutical Company, Wilmington, USA.
Bryson
J W
JW
DeGrado
W F
WF
D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D012996:Solutions
D012996:Solutions