[Severe protracted intrauterine impaired perfusion--a cause of enteral motility disorder in the premature infant].
The importance of measurement of blood flow in the fetal and uteroplacental circulations for the assessment of fetal wellbeing has been undisputed since some years. The present study is designed to prove if any relationship exists between severe hemodynamic disturbance in fetal as well as uteroplacental vessels and the occurrence of postnatal impairment of intestinal motility. The progress of 130 children, born in the University Women's Hospital Leipzig between 1991-1993 and with birth weights below 1500 g, has been analyzed. Doppler ultrasound examinations for detection of impairment in fetal and uteroplacental circulation were performed in all cases during pregnancy. A severe impairment of blood flow in the above mentioned circulations was defined by the presence of pathological pulsatility or resistance indices in both fetal and uteroplacental vessels as well as absent end diastolic flow in the umbilical artery and signs of centralization in the fetus. A severe hemodynamic impairment was found in 27 children and 26 of these were classified as severe hypotrophic after birth. The progress of these children was compared with this of other hypotrophic and euthrophic premature babies who had not revealed hemodynamic abnormalities. The incidence of disturbed postnatal intestinal motility (delayed meconium excretion, abdominal distention, retrograde peristalsis, subileus) was significantly higher in hypotrophic neonates with hemodynamic abnormalities in the course of pregnancy. Four of these newborns underwent surgery and surgical findings did not correlate with enterocolitis. The resumption of oral food intake for neonates who had hemodynamic impairments during pregnancy was delayed compared with the control groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Kinderklinik Universität Leipzig.
E
E
Tillig
R
R
Robel
C
C
Vogtmann
B
B
Viehweg
A
A
Möckel
D001724:Birth Weight / Q000502:physiology; D004761:Enterocolitis, Pseudomembranous / Q000151:congenital* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000503:physiopathology; D005333:Fetus / Q000098:blood supply*; D005746:Gastric Emptying / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology; D005865:Gestational Age; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007415:Intestinal Obstruction / Q000151:congenital* / Q000000981:diagnostic imaging / Q000503:physiopathology; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000151:congenital / Q000000981:diagnostic imaging / Q000503:physiopathology; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D012307:Risk Factors; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal
Die schwere protrahierte intrauterine Perfusionsstörung--eine Ursache der enteralen Motilitätsstörung des Frühgeborenen.