Halofantrine in the treatment of falciparum malaria.
50 patients (45 males + 5 females) suffering from acute uncomplicated attack of Plasmodium falciparum (Pf) malaria were treated with 1500 mg of halofantrine divided in three doses of 500 mg each given at an interval of 6 h. Results showed there were no primary treatment failures. Average Parasite Clearance Time (av. PCT) was 51.12 h and average Fever Clearance Time (av. FCT) was 31.25 h. Adverse Drug Reactions (ADR) were mild and self limiting. We conclude that halofantrine is a quite safe and effective new antimalarial agent in the treatment of Pf malaria cases.
Patel
K H
KH
Department of Medicine, Pathology, Medical College, Baroda, India.
Shastri
H
H
Patel
R Z
RZ
Parikh
P J
PJ
Patel
H R
HR
Pathak
K J
KJ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010616:Phenanthrenes / Q000009:adverse effects / Q000627:therapeutic use*
D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine