Female rhesus monkeys dosed with Aroclor 1254: analysis of polychlorinated biphenyl congeners in dam's milk and in the blood of dams and their offspring before, during, and after gestation.
Specific polychlorinated biphenyl (PCB) congeners were measured before, during, and after gestation in the blood of rhesus monkeys, as well as in their milk and in the blood of their infants during lactation, as part of a long-term feeding study to evaluate the toxicology of Aroclor 1254 on pre- and postnatal development of infant monkeys. During gestation a considerable shift from the higher to lower chlorinated biphenyls in the blood was observed in both dosed and nondosed animals. The contribution of penta- and hexachlorobiphenyls in the milk slightly increased with higher dosage. In addition, the percentages of 2,2'3,4,5'-,2,2',4,5,5'-, and 2,3,3',4',6-pentachlorobiphenyls were remarkably lower in the milk of dosed dams than in the originally ingested Aroclor 1254. PCB congener levels in infant blood increased during the lactation period but immediately decreased upon weaning. The lower chlorinated biphenyls virtually disappeared from infant blood after 16 weeks of nursing. Some correlations were observed between PCB congener levels in mother and infant and the congener ratios calculated.
Mes
J
J
Toxicology Research Division, Bureau of Chemical Safety, Health Canada, Ottawa, ON.
Arnold
D L
DL
Bryce
F
F
D000818:Animals; D001140:Aroclors / Q000378:metabolism* / Q000633:toxicity; D002849:Chromatography, Gas; D004785:Environmental Pollutants / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D005865:Gestational Age; D008253:Macaca mulatta; D008892:Milk / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D001140:Aroclors; D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls