Electrophysiology of dopamine D-1 receptors in the basal ganglia: old facts and new perspectives.
1. The dopamine (DA) D1-receptor family is highly represented in the mammalian brain and particularly in the nigrostriatal system, whose integrity is crucial for the execution of motor performances. 2. In the last decade, our understanding of the electrophysiology of D1 receptors on caudate-putamen neurons has greatly improved. The effects of the activation of striatal D1 receptors were studied by extracellular single unit recordings in the intact animal as well as by intracellular recordings in rat brain slice preparation. More recently, whole-cell recordings on isolated striatal neurons have further addressed this issue and confirmed the inhibitory modulatory role of D1 receptor on the electrical activity of striatal neurons. 3. Several important questions, however, concerning the functional effects of D1 receptor activation in the basal ganglia are still debated: the cellular segregation of the distribution of D1-D2-like receptors, their synergistic or opposite functional roles at the second messenger level, the effects of D1 receptor activation on the transmitter release and the modifications of D1 receptor pharmacology in dopamine-denervated striata. 4. A different perspective will also be discussed: the involvement of D1 receptors in long-term changes of synaptic efficacy in the striatum as a possible correlate of motor learning.
Clinica Neurologica, Università di Roma Tor Vergata, Italy.
A
A
Stefani
M
M
De Murtas
A
A
Pisani
F
F
Stratta
A
A
Bonci
N B
NB
Mercuri
P
P
Calabresi
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004594:Electrophysiology; D018408:Patch-Clamp Techniques; D017447:Receptors, Dopamine D1 / Q000187:drug effects* / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology
D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D013469:Sulpiride