Lipidemic effect of methanol.
The effect of methanol on some of the lipid components in serum was studied in rats. Methanol was administered by stomach tube in doses of 2 and 6 ml/kg b.wt daily for 21 and 6 days, respectively. Methanol was found to accumulate lipids; thus, cholesterol, phospholipids and triglycerides increased significantly. Concurrently, modification of the lipoid content of organs has been considered. It was concluded that methanol and not only formate, is toxic to rats, inspite of the alleged difference in routes of its metabolism in primates and rodents.
Gaafar
K M
KM
Dept of Zoology, Faculty of Science, Cairo University, Giza, Egypt.
Fayek
K I
KI
Taha
H M
HM
Kishta
O A
OA
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005561:Formates / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D000432:Methanol / Q000633:toxicity*; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005561:Formates; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D007770:L-Lactate Dehydrogenase; D000432:Methanol