[Possibilities of the use of MR tomography-based cerebral blood volume maps in the diagnosis of brain tumors].
OBJECTIVE
Today contrast enhanced MR imaging is a reliable method for detecting mostly distinguishing between different histological types of tumours. In this study we use a MR-based method to measure the regional cerebral blood volume (rCBV). Using this technique we try to judge the grading and vitality of the tumours.


METHODS
26 patients with various types of brain tumours were examined. To calculate rCBV-maps of one slice, low-dosed Gd-DTPA was injected as a bolus. Using the relaxation effect the obtained signal intensity-time curves were converted pixel-wise into rCBV images. For the tumours rCBV-ratios were calculated relative to the corresponding area in the contralateral hemisphere.


RESULTS
In the investigated group all tumours were detected on the basis of a raised rCBV-ratio. Since only vital parts of the tumour are perfused, the rCBV maps may be used to determine the place of biopsy.


CONCLUSIONS
The differential diagnosis of all histological tumour types was not possible on the basis of rCBV values. Distinction between low grade and high grade gliomas was also not significant. However, a low grade glioma can be excluded if the morphological images definitely indicate an astrocytoma and if the rCBV-ratio was higher than 2.
Hackländer
T
T
Institut für Diagnostische Radiologie, Heinrich-Heine-Universität Düsseldorf.
Hofer
M
M
Reichenbach
J
J
Bettag
J M
JM
Kiwit
J C
JC
Herzog
H
H
Mödder
U
U
D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis; D001810:Blood Volume; D001921:Brain / Q000098:blood supply*; D001932:Brain Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009837:Oligodendroglioma / Q000175:diagnosis
Einsatzmöglichkeiten von kernspintomographischen Parameterbildern des zerebralen Blutvolumens in der Diagnostik von Hirntumoren.