The inhibitory effects of propranolol on genital reflexes in male rats.
We have previously reported that propranolol adversely affects sexual behavior in male rats. To elucidate whether the effects of propranolol might involve decrements in ability, we examined two components of sexual function ex copula--ejaculatory reflex capacity and erectile reflexes. In the first study, we examined the effects of various doses of (+/-)-propranolol (1.25-10 mg/kg) administered subcutaneously. Marked inhibition was observed, evidenced by increases in the latency to ex copula ejaculation and to initial erection and decrements in the number of seminal emissions and in the number of erectile reflexes. Analyses of dose-response relationships indicated that the degree of inhibition increased with increasing dose. In the second study, we evaluated the stereo-selectivity of the responses. Both (+)- and (-)-propranolol (1.25 mg/kg) significantly inhibited ejaculatory reflex potential, and although (+)- and (-)-propranolol significantly inhibited erectile reflexes, (-)-propranolol had a greater effect. The data are interpreted to indicate that a) propranolol-induced sexual dysfunction involves both motivational and ability aspects; and b) propranolol-induced inhibition of genital reflexes may be due, at least in part, to mechanisms other than beta-adrenoceptor blockade.
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305, USA.
E R
ER
Smith
E J
EJ
Cetrulo
J P
JP
Donahue
H
H
Sparrow
J M
JM
Davidson
B B
BB
Hoffman
J T
JT
Clark
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D010410:Penile Erection / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D011433:Propranolol