Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness.
Intracerebral microinjections of gamma amino butyric acid were given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotransmitter in the genesis and regulation of sleep-wakefulness. GABA (50 micrograms/0.2 microliters) when administered through chronically implanted cannulae in free moving rats, did not produce any significant alterations in sleep-wakefulness. This may be attributed either to the non-involvement of GABA at the level of mPOA in the regulation of sleep, or to other factors like the low dose and rapid breakdown of the injected drug.
Department of Physiology, All India Institute of Medical Sciences, New Delhi.
D M
DM
Chari
V
V
Ramesh
J
J
John
V M
VM
Kumar
D000818:Animals; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid