Acute interstitial nephritis associated with loracarbef therapy.
We describe a biopsy-confirmed case of acute interstitial nephritis associated with the use of loracarbef in an 18-month-old boy, which resulted in end-stage renal failure. This complication has been documented with the use of beta-lactam antibiotics, and it seems likely the loracarbef was responsible for acute interstitial nephritis in this patient.
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA.
R E
RE
Thieme
S A
SA
Caldwell
G M
GM
Lum
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D001706:Biopsy; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D009336:Necrosis / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology*; D010033:Otitis Media / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C054920:loracarbef