In vivo setting behaviour of fast-setting calcium phosphate cement.
The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca10(PO4)6(OH)2) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-CPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillofacial surgery.
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan.
Y
Y
Miyamoto
K
K
Ishikawa
H
H
Fukao
M
M
Sawada
M
M
Nagayama
M
M
Kon
K
K
Asaoka
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D001843:Bone Cements / Q000737:chemistry* / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D017886:Durapatite / Q000737:chemistry; D005269:Femur / Q000378:metabolism / Q000502:physiology; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D019736:Prostheses and Implants / Q000592:standards; D051381:Rats; D017208:Rats, Wistar; D013718:Tensile Strength; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D017886:Durapatite