Immune-complex glomerulonephritis associated with Staphylococcus aureus infection of a totally implantable venous device.
We report a previously unrecognized complication of totally implanted subcutaneous ports. A patient with a totally implantable central venous device developed a septic syndrome. Blood and injection-reservoir cultures grew Staphylococcus aureus. There was no evidence of endocarditis. The port was removed but acute oliguric renal failure developed. A percutaneous renal biopsy showed acute diffuse proliferative glomerulonephritis. There was no extracapillary crescent. On immunofluorescence study, capillary wall granular deposits stained brightly for IgG and C3. These findings were thought to be consistent with infection-associated immune-complex glomerulonephritis.
Department of Haematology, Centre Hospitalier d'Argenteuil, France.
M
M
Pulik
F
F
Lionnet
P
P
Genet
C
C
Petitdidier
B
B
Vacher
D000368:Aged; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology; D007074:Immunoglobulin G / Q000378:metabolism; D007668:Kidney / Q000276:immunology; D013203:Staphylococcal Infections / Q000150:complications*
D003176:Complement C3; D007074:Immunoglobulin G