Availability of 0.3% ofloxacin ointment and solution in human conjunctiva and aqueous humor.
Ofloxacin 0.3% ophthalmic solution or ointment was administered preoperatively to 13 patients undergoing cataract surgery. Mean drug concentrations in conjunctival biopsies were 2.62 and 6.55 micrograms/gm and in aqueous humor samples were 0.36 micrograms/mL and 0.43 micrograms/mL, for ointment and solution respectively. Mean conjunctival concentrations of ofloxacin achieved MIC90 values for 419 gram-positive and gram-negative organisms previously analyzed.
Department of Pharmacokinetics, Allergan, Inc., Irvine, California, USA.
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D
Tang-Liu
J
J
Lambert
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S
Blancaflor
A
A
Gwon
D000368:Aged; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D001682:Biological Availability; D002387:Cataract Extraction; D003228:Conjunctiva / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics*; D009824:Ointments; D009883:Ophthalmic Solutions; D011817:Rabbits; D013666:Tears / Q000378:metabolism
D000890:Anti-Infective Agents; D009824:Ointments; D009883:Ophthalmic Solutions; D015242:Ofloxacin