[The effect of the blood serum factors of HIV-infected persons on the functional activity of the neutrophils in healthy donors].
The influence of 64 blood serum samples from HIV-infected patients at different stages of the infection on the functional activity of polymorphonuclear neutrophils (PMN) of 9 healthy donors was studied. In this study an increase in the production of oxygen radicals by PMN of the donors was revealed (in the chemiluminescence test), positive correlations between this increase and stages of HIV infection were followed. The presence of HIV-positive serum in the incubation medium led to the inhibition of phagocytosis and produced almost no changes in the capacity of PMN for its completion. A decrease in phagocytosis correlated with the level of complement and did not depend on other serum factors; on the contrary, an increase in chemiluminescence was not linked with the levels of complement, but had correlative relationships with the levels of anti-HIV antibodies and circulating immune complexes.
D I
DI
Gabrilovich
L A
LA
Ivanova
G K
GK
Shepeleva
L V
LV
Serebrovskaia
E V
EV
Buravtsova
V V
VV
Pokrovskiĭ
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005260:Female; D005609:Free Radicals / Q000097:blood; D015658:HIV Infections / Q000097:blood*; D015497:HIV-1; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D018375:Neutrophil Activation / Q000502:physiology*; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010587:Phagocytosis
D005609:Free Radicals; D010100:Oxygen
Vliianie faktorov syvorotki krovi VICh-infitsirovannykh lits na funktsional'nuiu aktivnost' neĭtrofilov zdorovykh donorov.