Soluble intercellular adhesion molecule 1 (ICAM-1) antigen in sera of bronchial asthmatics.
Previous studies have suggested that intercellular adhesion molecule 1 (ICAM-1, CD54) may be involved in the pathogenesis of asthma. In addition, a soluble form of ICAM-1 (sICAM-1) has been detected in increased concentrations in the sera of patients with certain inflammatory conditions. To determine whether bronchial asthma is associated with increased levels of sICAM-1 in serum and to assess the effects of therapy on these levels, the concentrations of sICAM-1 were measured in sera of healthy donors and asthmatic patients. The mean (+/- SD) level of serum sICAM-1 for 60 asthmatic patients (304.0 +/- 82.5 ng/mL) was significantly higher than that for 39 healthy volunteers (260.9 +/- 67.2 ng/mL; p = 0.004). Twenty-two patients considered to have atopic asthma and 24 patients with nonatopic asthma did not differ in their levels of sICAM-1. In 14 patients, serum concentrations of sICAM-1 were higher during asthma attacks than in the same patients during remission (p = 0.035). Serum sICAM-1 levels were lower in nine patients during treatment with oral prednisolone (2.5 to 40 mg/d) than during periods without systemic corticosteroid therapy (p = 0.002). Thus, active bronchial asthma is associated with the presence of increased levels of sICAM-1 in serum, and these levels may be modulated by corticosteroid therapy.
Department of Clinical Research, Kure Kyousai Hospital, Japan.
Y
Y
Shiota
J G
JG
Wilson
M
M
Marukawa
T
T
Ono
M
M
Kaji
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000485:Allergens; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001249:Asthma / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000503:physiopathology; D004391:Dust; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000503:physiopathology; D007073:Immunoglobulin E / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008925:Mites; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
D000485:Allergens; D018927:Anti-Asthmatic Agents; D004391:Dust; D005938:Glucocorticoids; D018799:Intercellular Adhesion Molecule-1; D007073:Immunoglobulin E; D011239:Prednisolone