Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.
A series of derivatives of 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute cancer cell line screen. Analysis by the COMPARE algorithm suggested that their cytotoxicity derived from interactions with tubulin. Significant inhibition of tubulin assembly and of the binding of radiolabeled colchicine to tubulin was demonstrated with several of the compounds, particularly NSC 145669, 175635, and 175636. The DHQZ derivatives are structurally analogous to a number of antimitotic agents, flavonols and derivatives of 2-styrylquinazolin-4(3H)-one and of 2-phenyl-4-quinolone. Structure-activity analogies between these agents, the combretastatins, and the colchicinoids were analyzed and summarized.
Laboratory of Molecular Pharmacology, National Intitutes of Health, Bethesda, MD 20892, USA.
E
E
Hamel
C M
CM
Lin
J
J
Plowman
H K
HK
Wang
K H
KH
Lee
K D
KD
Paull
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D001667:Binding, Competitive; D001921:Brain; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D003078:Colchicine / Q000378:metabolism; D006131:Growth Inhibitors / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D011034:Podophyllotoxin / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D011799:Quinazolines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000737:chemistry*; D014404:Tubulin / Q000737:chemistry* / Q000187:drug effects; D014747:Vinblastine / Q000378:metabolism
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D011799:Quinazolines; D013343:Styrenes; D014404:Tubulin; C071666:2-styrylquinazolin-4(3H)-one; D014747:Vinblastine; D011034:Podophyllotoxin; D003078:Colchicine