Relative resistance of rabbits to MPTP neurotoxicity.
The neurotoxic actions of MPTP and its 4-(O-tolyl) analog (2'-Me-MPTP) on two breeds of rabbits were investigated. MPTP, but not 2'-Me-MPTP, causes a reduction (about 40%) in striatal dopamine content in rabbits of the "little silver-black" breed. The dopamine content of striata of "chinchilla" rabbits was not affected by either agent.
Laboratory of Neurochemistry, Russian Academy of Sciences, Moscow Region, Russia.
N
N
Lermontova
O
O
Drany
D
D
Dobrota
V
V
Mezesova
V
V
Lombardi
S
S
Bachurin
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000633:toxicity*; D018492:Dopamine Antagonists / Q000633:toxicity; D020267:MPTP Poisoning; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000523:psychology; D011817:Rabbits; D013045:Species Specificity
D015259:Dopamine Agents; D018492:Dopamine Antagonists; C048977:1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine