Safety of lidocaine-prilocaine cream in the treatment of preterm neonates.
The safety of lidocaine-prilocaine cream (EMLA) was evaluated in an open trial in 30 preterm neonates (mean gestational age, 32.8 weeks; birth weight, 1911 gm); 0.5 gm was applied to the heel for 1 hour. Mean baseline and follow-up (4, 8, or 12 hours after EMLA application) methemoglobin levels were not different, ranging from 1.15% to 1.45%, and from 1.13% to 1.49%, respectively.
Taddio
A
A
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Shennan
A T
AT
Stevens
B
B
Leeder
J S
JS
Koren
G
G
D000700:Analgesics / Q000494:pharmacology*; D001724:Birth Weight; D003257:Consumer Product Safety; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D011318:Prilocaine / Q000494:pharmacology*
D000700:Analgesics; D011318:Prilocaine; D008012:Lidocaine