Complete remission of multicentric reticulohistiocytosis with combination therapy of steroid, cyclophosphamide, and low-dose pulse methotrexate. Case report, review of the literature, and proposal for treatment.
We describe a patient with multicentric reticulohistiocytosis in whom complete remission was achieved by sequential combination therapy with steroid, methotrexate, and cyclophosphamide. We reviewed all cases of complete or near-complete remissions of multicentric reticulohistiocytosis reported in the English-language literature and propose a new drug regimen for this rare but potentially disabling disease.
Liang
G C
GC
Northwestern University Medical School, Chicago, Illinois 60611, USA.
Granston
A S
AS
D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D015614:Histiocytosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D011241:Prednisone / Q000008:administration & dosage*; D012074:Remission Induction
D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate