Effect of cefotaxime or ceftriaxone treatment on nasopharyngeal Haemophilus influenzae type b colonization in children.
The effects of cefotaxime and ceftriaxone treatment on nasopharyngeal carriage of Haemophilus influenzae type b (Hib) were prospectively studied with 53 children with invasive Hib disease. Nasopharyngeal aspirates were monitored during therapy. Hib was eliminated within 2 days in 92% of patients and was eliminated in all patients after the third day of antibiotic treatment.
Microbiology Department, Women's and Children's Hospital, North Adelaide, Australia.
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Goldwater
D002439:Cefotaxime / Q000494:pharmacology* / Q000627:therapeutic use; D002443:Ceftriaxone / Q000494:pharmacology* / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D008297:Male; D009305:Nasopharynx / Q000187:drug effects / Q000382:microbiology*; D011446:Prospective Studies
D002511:Cephalosporins; D002443:Ceftriaxone; D002439:Cefotaxime