Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases.
Tamanoi
F
F
Department of Microbiology and Molecular Genetics, University of California at Los Angeles 90024, USA.
Mitsuzawa
H
H
D019883:Alkyl and Aryl Transferases; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D005800:Genes, Fungal; D016296:Mutagenesis; D009154:Mutation; D017368:Protein Prenylation; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics*; D013379:Substrate Specificity; D014166:Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics*; D018631:ras Proteins / Q000378:metabolism
D004791:Enzyme Inhibitors; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D018631:ras Proteins