[Enzymatic mechanisms of resistance to aminoglycoside antibiotics in gram negative bacilli from Chilean hospitals].
The presence of aminoglycoside modifying enzymes (AMEs) has been investigated, by an agar diffusion method, in 344 strains of aminoglycoside-resistant Gram negative bacilli isolated in different Chilean hospitals. Most of the strains exhibited a combination of enzymatic mechanism of resistance, but two acetylating (AAC(3)II and AAC(6')I) and one phosphorylating (APH(3')I) enzymes were the main mechanism detected in the strains. A significant increase in the frequency of strains producing AAC(6')I, possible due to wide use of amikacin, has been found when results were compared with those of a report published in 1985.
Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
E
E
Del Solar
A
A
García
H
H
Bello
M
M
Domínguez
G
G
González
R
R
Zemelman
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002677:Chile; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
Mecanismos enzimáticos de resistencia a antibióticos aminoglicósidos en bacilos gram negativos de hospitales chilenos.