Staphylococcal enterotoxin is a bovine T cell superantigen.
Different isoforms of soluble staphylococcal enterotoxins (SE): SEB, SEC-1 and SEC-2, were shown to stimulate bovine T cell proliferation, expression of cytokine messages, and IgG production. Intact metabolic function of APC was not required since peripheral blood mononuclear cells (PBMC), UV-irradiated prior to or following incubation with SE, were both capable of presenting SE, while PBMC treated with MAbs against MHC II lost the ability to stimulate T cell proliferation. SE caused approximately two fold increase of CD4+, and CD8+ T cells, but not MHC II+ APC or B cells. This model system suggests that SE transduces not only T cell activation signal, but also a non-proliferative signal for primary B cells to produce polyclonal IgG. We hypothesize that enterotoxin virulence may be in part due to its effect on activating the immune system.
Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, USA.
R
R
Schmaltz
B
B
Bhogal
Y Y
YY
Wang
T
T
Petro
S S
SS
Chen
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D008213:Lymphocyte Activation; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013552:Swine / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004768:Enterotoxins; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G; D007376:Interleukin-2; D018089:Superantigens; C031818:enterotoxin B, staphylococcal; C034959:enterotoxin C, staphylococcal; D007371:Interferon-gamma