Preparation and biological behaviour of 99mTc-carbonyl and 99mTc-nitrido complexes of cysteine and some cysteine esters.
The preparation of 99mTcO-, 99mTcN- and 99mTc(CO)-complexes of cysteamine (CYA), cysteine (CYS) and the methyl (CME) and ethyl (CEE) esters of cysteine is described. All complexes were stable and their biological behaviour in mice was studied. Most complexes were found to clear predominantly via the renal pathway with TcN- and Tc(CO)-complexes exhibiting greater urinary clearance than the corresponding TcO-complex. 99mTcN-CME, 99mTc(CO)-CME and 99mTc(CO)-CYS were found to be rapidly cleared via the kidneys and the effect of probenicid on renal clearance was studied to determine whether tubular excretion was involved. The results suggest that tubular secretion is involved in the renal clearance of 99mTcN-CME and Tc(CO)-CYS.
Australian Radiation Laboratory, Yallambie, VIC, Australia.
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Bonnyman
D000818:Animals; D003543:Cysteamine / Q000031:analogs & derivatives; D003545:Cysteine / Q000031:analogs & derivatives*; D004952:Esters / Q000138:chemical synthesis / Q000493:pharmacokinetics; D007553:Isotope Labeling / Q000379:methods; D007668:Kidney / Q000378:metabolism; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D004952:Esters; D015609:Organotechnetium Compounds; D003543:Cysteamine; D003545:Cysteine