Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene.
The human CDX1 gene has been isolated from a small intestine cDNA library using a murine Cdx1 cDNA probe. The nucleotide sequence of CDX1 is 81% identical to murine Cdx1 and predicts a 265-amino-acid protein with 85% identity to the mouse protein (98% identity, including conservative amino acid changes). The CDX1 locus has been mapped to a cosmid contig from chromosome 5q31-q33, placing CDX1 approximately 100 kb distal to CSFIR. Expression of CDX1 in adults appears to be limited to the intestine and colon by Northern analysis, suggesting a possible role in the terminal differentiation of the intestine. Further analysis of CDX1 should elucidate the function of caudal-type homeobox genes in human development.
Bonner
C A
CA
Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717, USA.
Loftus
S K
SK
Wasmuth
J J
JJ
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003106:Colon / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D013045:Species Specificity
D030161:Avian Proteins; C491273:CDX1 protein, human; C491272:Cdx1 protein, mouse; D018076:DNA, Complementary; D018398:Homeodomain Proteins