Synthesis of novel intranuclear diazasteroids.
By use of the aza Diels-Alder reaction a series of aminoisoquinolines and aminoquinolines have been elaborated to provide an effective synthesis of diverse diazasteroids. In particular, representative 1,11-diaza-, 3,11-diaza-, and 4,11-diazasteroids have been synthesized from cyclopentadiene. From dihydropyran a 4,11-diaza-15-oxa-D-homosteroid has been obtained.
Mellor
J M
JM
Department of Chemistry, Southampton University, UK.
Merriman
G D
GD
D000634:Aminoquinolines / Q000737:chemistry; D001378:Azasteroids / Q000138:chemical synthesis*; D005557:Formaldehyde / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry
D000634:Aminoquinolines; D001378:Azasteroids; D011714:Pyrans; D005557:Formaldehyde