[The effect of individual serum proteins and native blood serum on the adhesion of Staphylococcus aureus to cells in vitro].
Blood serum and its components were found to produce an antiadhesive effect which inhibited the attachment of S.aureus to cells HEp-2 and immortalized astrocytes. Normal and antistaphylococcal immunoglobulins exhibited the highest activity, inhibiting the process of bacterial adhesion in a serum-free medium. The antiadhesive activity level of native serum was considerably lower and constituted 4% of that of normal immunoglobulin and 85% of that of albumin. In spite of pronounced inhibiting action of normal immunoglobulin and albumin, their dissolution in serum did not increase its antiadhesive activity.
Eropkina
E M
EM
Afinogenov
G E
GE
Eropkin
M Iu
MIu
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000382:microbiology; D001422:Bacterial Adhesion / Q000187:drug effects*; D001790:Blood Physiological Phenomena; D001798:Blood Proteins / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D006168:Guinea Pigs; D006801:Humans; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity*
D001798:Blood Proteins
Vliianie otdel'nykh syvorotochnykh belkov i nativnoĭ syvorotki krovi na adgeziiu Staphylococcus aureus k kletkam in vitro.