Angiogenesis as a component of epithelial-mesenchymal interactions.
Here we review the role of angiogenesis as it pertains to the interactions between the epithelium and the mesenchyme, especially during tumor growth and metastasis. We illustrate and discuss several models of angiogenesis including endothelial tube formation on Matrigel. Finally, we examine angiogenic factors using the Matrigel model and investigate several other matrix molecules for their importance in angiogenesis and epithelial/stromal interactions.
Grant
D S
DS
Cardeza Foundation for Hematological Research, Thomas Jefferson University, College of Medicine, Philadelphia, PA 19107, USA.
Rose
R W
RW
Kinsella
J K
JK
Kibbey
M C
MC
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D003094:Collagen; D004338:Drug Combinations; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007797:Laminin / Q000502:physiology; D008648:Mesoderm / Q000473:pathology / Q000502:physiology*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D011509:Proteoglycans; D014407:Tumor Cells, Cultured
D004338:Drug Combinations; D006133:Growth Substances; D007797:Laminin; D011509:Proteoglycans; C059485:matrigel; D003094:Collagen