Prospective epidemiologic study of painful and neurologic sequelae induced by herpes zoster in patients treated early with oral acyclovir.
Three hundred and one patients with acute herpes zoster treated early with oral acyclovir were enrolled in an open, prospective study designed to evaluate painful and neurologic disorders over a 6-month period. Age, initial pain severity, and occurrence of a neurologic deficit influenced the incidence of postherpetic neuralgia. No relationship was found between initial rash severity and either pain incidence or neurologic deficit.
Bruxelle
J
J
Department of Anesthesiology, Hospital Cochin-Tarnier, Paris, France.
D000212:Acyclovir / Q000008:administration & dosage*; D000284:Administration, Oral; D000368:Aged; D006562:Herpes Zoster / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D010146:Pain / Q000453:epidemiology* / Q000209:etiology; D011446:Prospective Studies
D000212:Acyclovir