Characterization of the human XPA promoter.
We cloned the human xeroderma pigmentosum group A gene (XPA) and characterized the XPA promoter (pXPA) by transient cat expression. The pXPA is extraordinarily weak in human fibroblasts (1% of RSV-LTR) and appears to function without any of the usual promoter elements. Regions containing positive and negative control elements were localized.
Topping
R S
RS
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.
Myrand
S P
SP
Williams
B L
BL
Albert
J C
JC
States
J C
JC
D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D014983:Xeroderma Pigmentosum / Q000235:genetics*; D051760:Xeroderma Pigmentosum Group A Protein
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D051760:Xeroderma Pigmentosum Group A Protein