Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism.
Autism likely results from several different etiologies or a combination of pathological mechanisms. Recent studies suggest that this disorder may be associated with immune abnormalities, pathogen-autoimmune processes and perhaps the major histocompatibility complex (MHC). In a preliminary study we found that 22 autistic subjects had an increased frequency of the extended or ancestral MHC haplotype B44-SC30-DR4. The current study attempted to confirm this observation by studying 23 additional randomly chosen autistic subjects, most of their parents and 64 unrelated normal subjects. In agreement with earlier findings B44-SC30-DR4 was associated with autism. In combining the data from the original and current studies, B44-SC30-DR4 or a substantial fragment of this extended haplotype was represented in 40% of the autistic subjects and/or their mothers as compared to about 2% of the unrelated subjects. It is concluded that one or more genes of the MHC is (are) involved in the development of some cases of autism.
Daniels
W W
WW
Center for Persons with Disabilities, Utah State University, Logan 84322, USA.
Warren
R P
RP
Odell
J D
JD
Maciulis
A
A
Burger
R A
RA
Warren
W L
WL
Torres
A R
AR
D001321:Autistic Disorder / Q000209:etiology* / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics*; D005190:Family; D005260:Female; D006680:HLA Antigens; D006239:Haplotypes; D006801:Humans; D008297:Male
D006680:HLA Antigens