[Lipid peroxidation in the presence of inorganic compounds. Relation to oxidative stress mechanisms].
Oxidizing activity study of inorganic compounds is based on a mechanistic approach. This approach implies research of the capacity of these materials, after interaction with molecular oxygen, to generate activated oxygen species (AOS) in aqueous medium. These electrophilic species are able to participate in oxidative stress processes and some AOS differ in their oxidizing power; highly oxidizing species (A*) and entities (P*) less oxidizing than A*. These AOS are capable of initiating linolenic acid peroxidation leading to formation of different degradation products such MDA, monoaldehydes, conjugated dienes and trienes, hydroperoxydes, and ethane. The detection of these products allows to reveal the presence of AOS. Our data show that the global assessment of lipid peroxidation should be established from the whole of formed peroxidation products and not from one type of degradation products.
Laboratoire de Réactivité de Surface, Université P. et M. Curie, CNRS URA 1106, Paris.
J
J
Fournier
E
E
Copin
S
S
Chouchane
S
S
Dzwigaj
J
J
Guignard
D017632:Asbestos, Serpentine / Q000494:pharmacology*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D017895:Manganese Compounds / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D017962:alpha-Linolenic Acid / Q000378:metabolism
D017632:Asbestos, Serpentine; D017895:Manganese Compounds; D017382:Reactive Oxygen Species; D017962:alpha-Linolenic Acid
Peroxydation lipidique en présence de composés inorganiques. Relation avec les mécanismes du stress oxydant.