In vivo 31P spectroscopy study of treated and untreated recovery of rat partial brain ischemia.
Quantitative 31P NMR was used to follow the time variation of the hypometabolic response to hypoxic partial ischemia in an animal model. The purpose of the study was to establish the value of this repeated spectroscopy operating by means of a surface coil. It aimed at determining whether a therapeutic intervention could influence the transient changes occurring during the insult or early recovery. A pharmacological substance was thus used during a reversible forebrain ischemia, induced by a combination of vascular occlusion and mild hypoxia in two groups of rats. As an available and convenient example, L-carnitine was chosen. Statistical analysis of the experimental results revealed a significant difference of the Pi and PCr levels between treated and untreated animals.
Macri
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MA
Dipt. di Fisica, Università di Roma La Sapienza, Italy.
Campanella
R
R
De Luca
F
F
Montalbano
A
A
Taggi
F
F
Maraviglia
B
B
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001488:Basilar Artery; D002331:Carnitine / Q000008:administration & dosage / Q000627:therapeutic use; D002339:Carotid Arteries; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D002534:Hypoxia, Brain / Q000188:drug therapy / Q000378:metabolism; D007262:Infusions, Intravenous; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010084:Oxidation-Reduction; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010759:Phosphorus Isotopes; D016548:Prosencephalon / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
D005227:Fatty Acids; D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D002331:Carnitine