[Dominant monogenic markers of quantitative characters].
Peculiarities of interdependent variation of monogenic and polygenic traits were analyzed using a one-locus diallelic model of a monogenic, dominantly inherited trait. The possibility of determining the mean genotypic value of the trait (m) and also the additive (a) and nonadditive (d) effects of the interaction between alleles of a monogenic trait on a quantitative trait is considered. It is shown that a and d can differ from zero even if the mean values in the groups with dominant and recessive phenotypes are equal. Equations are presented that allow the direct use of data obtained in population studies for determining m, a, and d, as well as corresponding standard errors under the conditions of codominance and dominance of the monogenic trait. Another group of equations allows determination of the sample size necessary for calculating m, a, and d. The problem concerning the ambiguity of m, a, and d values calculated using the proposed equations is discussed. This ambiguity depends on the fact that identification of genotypes in the case of a dominantly inherited monogenic trait is impossible.
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Bezrukov
D000483:Alleles; D005075:Biological Evolution; D002874:Chromosome Mapping; D005799:Genes, Dominant; D005808:Genes, Recessive; D005819:Genetic Markers; D014644:Genetic Variation; D005838:Genotype; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D010641:Phenotype; D015203:Reproducibility of Results; D012641:Selection, Genetic
D005819:Genetic Markers
Dominantnye monogennye markery kolichestvennykh priznakov.