[Prognostic factors of hepatocellular carcinoma: a multivariate analysis in 113 patients].
The aim of this study was to identify clinical, biological or morphological prognostic factors in 113 patients with HCC in terms of survival. All patients (100 men, aged 65 [28-85], 95% cirrhosis) were diagnosed between 1982-1990. Mean survival time was 21 +/- 3 weeks. Eleven (over 25) variables were isolated by univariate analysis. A multivariate survival analysis (Cox regression model) disclosed that serum creatinine (p = 0.0002), alkaline phosphatase (p = 0.02) and Okuda's stage (p = 0.025) were independent predictors of survival. Comparison of survival curves for different values of these prognostic variables allows division of patients in three groups of prognostic significance in terms of survival (p < 0.05).


CONCLUSIONS
these results facilitate stratification of patients with HCC to design and evaluate future controlled trials.
Service de médecine interne E, hôpital Saint-Eloi, Montpellier, France.
M
M
Ychou
M
M
Veyrac
B
B
Hanslik
M
M
Abouhafss
J P
JP
Daures
P
P
Perney
J
J
Pinto
J M
JM
Bruel
F
F
Blanc
H
H
Michel
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000401:mortality / Q000628:therapy; D005260:Female; D005355:Fibrosis / Q000150:complications; D006801:Humans; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
Facteurs pronostiques du carcinome hépatocellulaire: étude multivariée chez 113 patients.