Familial non-specific dementia maps to chromosome 3.
A significant minority of degenerative dementias lack distinctive inclusion bodies, plagues or tangles on pathological examination. Half of these cases have a positive family history of dementia. We have studied the largest published family with such a dementia and mapped the disease locus to a 12 cM region of chromosome 3 spanning the centromere. Haplotype analysis demonstrates a common region shared between all affected individuals between the markers D3S1284 and D3S1603. Like a number of other late onset neurodegenerative diseases, the disease presents at an earlier age when paternally inherited.
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK.
J
J
Brown
A
A
Ashworth
S
S
Gydesen
A
A
Sorensen
M
M
Rossor
J
J
Hardy
J
J
Collinge
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D003704:Dementia / Q000235:genetics*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree