Evaluation of a new dentifrice for the treatment of sensitive teeth.
A dentifrice containing 5% potassium nitrate, 1.3% soluble pyrophosphate, 1.5% polyvinylmethyl ether and maleic acid (PVM/MA) copolymer and 0.243% sodium fluoride in a silica base (Sensitive/Tartar Control) has been developed to concomitantly control tartar, caries and dentinal hypersensitivity. In vitro and animal studies show that the fluoride in this product effectively inhibits formation of enamel and dentine caries. In vitro studies also demonstrate that this dentifrice effectively reduces hydraulic conductance by occluding dentine tubules with a mixed surface deposit of copolymer and silica. Using an in vitro model that simulates in vivo conditions, this dentifrice also allows a rapid penetration of potassium nitrate through the dentine matrix. These findings demonstrate a correlation under in vivo conditions between the occlusion of dentine and the ability to deliver topically applied agents to target sites within or below dentine. The results indicate that this new dentifrice should provide multiple clinical therapeutic benefits including controlling tooth decay and tartar formation, and reducing and preventing dentinal hypersensitivity.
Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA.
S
S
Miller
A
A
Gaffar
R
R
Sullivan
R
R
Heu
T
T
Truong
M
M
Stranick
D000818:Animals; D003728:Dental Calculus / Q000517:prevention & control; D003731:Dental Caries / Q000517:prevention & control; D003802:Dentifrices / Q000494:pharmacology / Q000627:therapeutic use*; D003804:Dentin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D003806:Dentin Permeability / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000188:drug therapy* / Q000503:physiopathology; D011756:Diphosphates / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D006801:Humans; D006874:Hydrostatic Pressure; D008298:Maleates / Q000494:pharmacology / Q000627:therapeutic use; D008855:Microscopy, Electron, Scanning; D009566:Nitrates / Q000494:pharmacology / Q000627:therapeutic use*; D009584:Nitrogen / Q000032:analysis; D011095:Polyethylenes / Q000494:pharmacology / Q000627:therapeutic use*; D011188:Potassium / Q000493:pharmacokinetics; D017680:Potassium Compounds / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012212:Rheology; D012825:Silicon / Q000032:analysis; D012969:Sodium Fluoride / Q000627:therapeutic use*; D013499:Surface Properties; D014089:Tooth Remineralization
D003802:Dentifrices; D011756:Diphosphates; D004338:Drug Combinations; D008298:Maleates; D009566:Nitrates; D011095:Polyethylenes; D017680:Potassium Compounds; C097426:Sensitive Tartar Control Dentifrice; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D009584:Nitrogen; C023844:potassium nitrate; D011188:Potassium; D012825:Silicon