Pemoline effects on children with ADHD: a time-response by dose-response analysis on classroom measures.
OBJECTIVE
To evaluate the dose-response by time-response characteristics of pemoline (Cylert) on dependent measures of behavior and academic performance in a laboratory classroom.


METHODS
After a 2-week baseline, a double-blind crossover design was used to compare placebo, 18.75 mg, 37.5 mg, 75 mg, and 112.5 mg of pemoline, q.a.m., with each dose administered for 1 week. Medication was given at 9:00 A.M., and performance was measured beginning immediately and beginning 2, 4, and 6 hours after ingestion. The dependent measures included number of math problems completed correctly, teacher-recorded rates of on-task behavior and noncompliance, and teacher ratings on an Abbreviated Conners Teacher Rating Scale.


RESULTS
There were linear effects of medication, with pemoline doses greater than 18.75 mg having an effect beginning 2 hours after ingestion and lasting through the seventh hour after ingestion.


CONCLUSIONS
Results are contrasted with widespread misbeliefs regarding pemoline's time course and efficacy.
University of Pittsburgh, USA.
W E
WE
Pelham
J M
JM
Swanson
M B
MB
Furman
H
H
Schwindt
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010389:Pemoline / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D012574:Schools; D013997:Time Factors
D000697:Central Nervous System Stimulants; D010919:Placebos; D010389:Pemoline