In vitro activity of piperacillin/tazobactam against recent clinical isolates from hospitalized patients in ten Belgian hospitals.
The in vitro activity of the combination piperacillin/tazobactam has been compared to that of piperacillin, ticarcillin/clavulanate, cefotaxine, ceftazidime, imipenem and ciprofloxacin against 678 Enterobacteriaceae, 173 nonfermenters, 185 staphylococci, 96 E. faecalis, 217 S. pneumoniae, 202 H. influenzae and 178 M. catarrhalis isolated from hospitalized patients. Piperacillin/tazobactam was similar in activity to third generation cephalosporins, imipenem and ciprofloxacin, and more active than piperacillin alone and ticarcillin/clavulanate.
Department Microbiologie, Universitair Ziekenhuis St-Rafaël, Leuven, Belgium.
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D001419:Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin