Water deprivation in the rat induces nitric oxide synthase (NOS) gene expression in the hypothalamic paraventricular and supraoptic nuclei.
We examined the effects of water deprivation on nitric oxide synthase (NOS) gene expression in the rat hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), using in situ hybridization histochemistry. Dehydration caused a significant increase in NOS gene transcripts in the PVN and SON but not in the subfornical organ (SFO). The results suggest that dehydration has a major effect on the NOS gene expression in the PVN and SON.
Department of Medicine, University of Bristol, Bristol Royal Infirmary, UK.
Y
Y
Ueta
A
A
Levy
H S
HS
Chowdrey
S L
SL
Lightman
D000818:Animals; D015870:Gene Expression / Q000235:genetics*; D007031:Hypothalamus / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D019001:Nitric Oxide Synthase / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus / Q000378:metabolism*; D014868:Water Deprivation
D019001:Nitric Oxide Synthase