Prolactin induced analgesia is dependent on ATP sensitive potassium channels.
1. The role of ATP sensitive potassium channels in the analgesic activity of prolactin (PRL) was studied in mice using glibenclamide and minoxidil, a blocker and an opener of these channel, respectively. 2. Pre-treatment with glibenclamide attenuated the analgesic activity of PRL while treatment with minoxidil potentiated the activity. 3. It is concluded that PRL, similar to morphine, utilizes ATP sensitive potassium channels in eliciting the analgesic response.
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education, Pondicherry, India.
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Shewade
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Ramaswamy
D000085:Acetates; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008914:Minoxidil / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011388:Prolactin / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D000085:Acetates; D000700:Analgesics; D007004:Hypoglycemic Agents; D015221:Potassium Channels; D011957:Receptors, Opioid; D014665:Vasodilator Agents; D008914:Minoxidil; D000255:Adenosine Triphosphate; D011388:Prolactin; D005905:Glyburide