Partial recovery of renal function in black patients with apparent end-stage renal failure due to primary malignant hypertension.
We report the largest series in which 12 out of 54 patients with primary malignant hypertension requiring dialysis recovered sufficient renal function to allow withdrawal of dialysis. The patients were divided into recovery (RC; n = 12) and non-recovery (N-RC; n = 42) groups. The two groups were compared for variables which might predict RC. They were also assessed for survival. Nine of the RC and 6 of the N-RC patients presented with acute oliguria (p = 0.01). The initial mean arterial pressure was significantly higher in the RC than the N-RC group (178 +/- 17 vs. 160 +/- 27 mm Hg; p = 0.03). Although not statistically significant, more females recovered (8 of 12 vs. 16 of 42; p < 0.1). More patients presenting with serum creatinine concentrations < 1,000 mumol/l (11 mg/dl) recovered (p = 0.09), while the presence of microangiopathic-haemolytic anaemia occurred more frequently in the RC (7 of 10) than in the N-RC (15 of 35) group (p = 0.16)> Age, kidney size, and the presence of hypertensive retinopathy did not distinguish between the two groups. RC patients had a greater long-term survival (Mantel-Cox chi2 = 4.48; p = 0.03). The renal function RC may be related to the type of dialysis provided (intermittent peritoneal dialysis) and to the use of modern potent peripheral vasodilator antihypertensive agents. Potential renal function RC should always be considered in patients being dialyzed for primary malignant hypertension.
Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.
S H
SH
James
A M
AM
Meyers
F J
FJ
Milne
S G
SG
Reinach
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044383:Black People; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006974:Hypertension, Malignant / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D010349:Patient Compliance; D010530:Peritoneal Dialysis; D012074:Remission Induction
D000959:Antihypertensive Agents; D003404:Creatinine