von Willebrand's disease in Dobermann dogs in Australia.
Over a 5-year period (1988-92), von Willebrand factor antigen (vWf:Ag) concentrations were determined on plasma samples from 614 Dobermanns. The vWf:Ag concentration was < 50 canine units (CU)/dL in 373 dogs (61%); these dogs were classified as carriers of the von Willebrand's disease (vWD) gene. In order to identify which dogs were at risk of haemorrhage due to vWD, we determined a cut-off vWf:Ag concentration below which dogs could be considered at risk. This cut-off was chosen in order to minimise the number of dogs genuinely at risk of haemorrhage, being wrongly classified as not at risk. This was done without sacrificing the specificity of the cut-off to any great extent. A vWf:Ag concentration of < 36 CU/dL was empirically chosen as the optimum cut-off concentration. In 282 dogs (76% of the carriers), the vWf:Ag concentration was below this cut-off and these dogs were, thus, classified as being at risk of haemorrhage due to vWD. Haemorrhage attributable to vWD was seen in 107 dogs (29% of the carriers, or 17% of all the dogs). Haemorrhage mostly followed trauma or surgery, but spontaneous genito-urinary and gastrointestinal haemorrhages were also frequent. Of these dogs, 92 were of known age, with a median of 3 years, and 102 were of known sex, with 61% being female. In 89 dogs in which the severity of haemorrhage was subjectively assessed, mild and moderate bleeding occurred with similar frequency (48% and 43%, respectively). There were 8 cases of severe haemorrhage, with two deaths.(ABSTRACT TRUNCATED AT 250 WORDS)
Stokol
T
T
Department of Veterinary Science, University of Melbourne, Werribee, Victoria.
Parry
B W
BW
Mansell
P D
PD
D000818:Animals; D000941:Antigens / Q000032:analysis; D001315:Australia / Q000453:epidemiology; D003627:Data Interpretation, Statistical; D004283:Dog Diseases / Q000453:epidemiology* / Q000276:immunology; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006580:Genetic Carrier Screening; D006470:Hemorrhage / Q000209:etiology / Q000662:veterinary; D006579:Heterozygote; D008297:Male; D015995:Prevalence; D014842:von Willebrand Diseases / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; C029417:Von Willebrand antigen; D014841:von Willebrand Factor