[The activation of Yersinia pestis "murine" toxin and endotoxin by hemolyzed erythrocytes from mammalian blood].
Y. pestis "mouse" toxin and endotoxin have been found to be capable of being activated with hemolyzed mammalian red blood cells. The LD50 of the activated endotoxin decreases 5-10 times in comparison with the initial preparation. The LD50 of the activated "mouse" toxin decreases 5 times. As revealed in this study, the joint introduction of nonlethal doses of "mouse" toxin and endotoxin is highly toxic for white mice and guinea pigs. The presence of both "mouse" toxin and endotoxin in the toxic mixture is an essential factor for these two species of animals.
Tynianova
V I
VI
Demidova
G V
GV
Ziuzina
V P
VP
Bespalova
I A
IA
Kubantseva
E P
EP
Goncharov
E K
EK
Pasiukova
N I
NI
D000818:Animals; D001427:Bacterial Toxins / Q000302:isolation & purification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000302:isolation & purification / Q000633:toxicity*; D004912:Erythrocytes / Q000382:microbiology*; D004926:Escherichia coli; D006017:Glycolipids / Q000302:isolation & purification / Q000633:toxicity; D006168:Guinea Pigs; D006461:Hemolysis; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D010957:Plasmids; D011994:Recombinant Proteins / Q000633:toxicity; D015010:Yersinia pestis
D001427:Bacterial Toxins; D004731:Endotoxins; D006017:Glycolipids; D011994:Recombinant Proteins
Aktivatsiia "myshinogo" toksina i éndotoksina Yersinia pestis gemolizirovannymi éritrotsitami krovi mlekopitaiushchikh.