Ion channel forming colicins.
Entry of proteins into membranes and transmembrane ion channel formation are two fundamental aspects of membrane biology. The ion channel forming colicins beautifully exemplify both properties. Recent results delineate the structure of a whole colicin; coupled with new biophysical studies, a mechanism for insertion is proposed.
Stroud
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Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448, USA.
D001692:Biological Transport; D003087:Colicins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D007109:Immunity / Q000235:genetics; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D003087:Colicins; D007473:Ion Channels