Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy.
alpha 1-Blocking agents (alphuzosine and terazosine) have been tested to determine their effectiveness over a placebo in the treatment of premature ejaculation. A total of 91 patients, all of whom were resistant to psychological therapy, were submitted to a double-blind controlled cross-over trial. Side effects were recorded as well. Alphuzosine and terazosine proved effective in approximately 50% of the cases and were, thus, significantly more active than the placebo; moreover no significant difference was found between them in terms of side effects. It is concluded that alpha 1 blockers are reasonably safe active drugs, effective in the treatment of premature ejaculation which does not respond to the psychological approach.
Department of Urology, Adria Hospital, Italy.
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Cavallini
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011613:Psychotherapy; D011799:Quinazolines / Q000627:therapeutic use*; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000628:therapy
D000317:Adrenergic alpha-Antagonists; D011799:Quinazolines; C041226:Terazosin; C047638:alfuzosin; D011224:Prazosin