[Hypocorticism due to selected deficiency of CRH with spontaneous resolution. A case report].
Hypocortisolism derived from hypothalamic deficiency of corticotropin releasing hormone is a highly unusual cause of adrenal insufficiency, and its pathogenesis is still not fully understood. We report a mildly symptomatic patient having repeated low basal plasma cortisol levels with normal cortisol response to ACTH and Lysine-vasopressin; however, she showed a clearly limited response to deep hypoglycemia, while GH reached a normal concomitant response. After 7 years of cortisol replacement the endogenous cortisol returned spontaneously to normality. The rest of pituitary function has been always normal.
Departamento de Endocrinología, Metabolismo y Nutrición, P Universidad Católica de Chile, Santiago de Chile.
J M
JM
López
I E
IE
Cárdenas
D000309:Adrenal Insufficiency / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000368:Aged; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000172:deficiency*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000627:therapeutic use; D008236:Lypressin / Q000494:pharmacology; D012075:Remission, Spontaneous
D008236:Lypressin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone
Hipocortisolismo por déficit selectivo de CRH de resolución espontánea. Análisis de un caso.