[The interferonogenic properties of yeast RNA-tilorone complexes in a cell culture].
The use of molecular complexes of yeast RNA with thyloron as inductors of type I interferons (alpha/beta-interferons) in the culture of cells L929 is described. It was shown that the complexes induced the interferon synthesis in the cells at the level comparable to that of the standard inductors of the polyribonucleotide nature i.e. larifan and poly(I)-poly(C). In the experimental doses the complexes proved to be nontoxic. It was concluded that the use of the yeast RNA and thyloron complexes as inductors in large-scale production of type I interferons was promising.
Karpov
A V
AV
Zholobak
N M
NM
D000818:Animals; D002478:Cells, Cultured; D004271:DNA, Fungal / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007369:Interferon Inducers / Q000494:pharmacology* / Q000633:toxicity; D007372:Interferons / Q000032:analysis; D007739:L Cells; D051379:Mice; D009930:Organic Chemicals; D011070:Poly I-C / Q000494:pharmacology; D013994:Tilorone / Q000494:pharmacology* / Q000633:toxicity
D004271:DNA, Fungal; D007369:Interferon Inducers; D009930:Organic Chemicals; C066530:larifan; D007372:Interferons; D013994:Tilorone; D011070:Poly I-C
Izuchenie interferonogennykh svoĭstv kompleksov drozhzhevaia DNK--tiloron v kul'ture kletok.