Synthesis of phospholipid polymers having a urethane bond in the side chain as coating material on segmented polyurethane and their platelet adhesion-resistant properties.
Surface modification of segmented polyurethanes (SPUs) was carried out using new blood compatible polymers having both phospholipid polar groups and urethane bonds in the side chains. The polymers were composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA) and methacrylate with a urethane bond (MU). The MPC copolymers were soluble in ethanol. The SPU membranes were immersed in an ethanol solution of MPC copolymers and dried in vacuo for coating. The surface formed was completely covered with the MPC copolymer which was confirmed by X-ray photoelectron spectroscopic analysis. The polymer coatings were hardly detached in water, ethanol and 40% aqueous solution of ethanol compared with poly(MPC-co-BMA) which did not have the MU moieties. Therefore, the MU moieties had affinity for the SPU. The surface modification of the SPUs suppressed platelet adhesion effectively after contact with platelet-rich plasma for 180 min.
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
K
K
Ishihara
H
H
Hanyuda
N
N
Nakabayashi
D001672:Biocompatible Materials / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010743:Phospholipids / Q000138:chemical synthesis*; D010973:Platelet Adhesiveness; D011108:Polymers / Q000138:chemical synthesis*; D011140:Polyurethanes / Q000737:chemistry*; D012995:Solubility; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D008689:Methacrylates; D010743:Phospholipids; D011108:Polymers; D011140:Polyurethanes; D014867:Water; D000431:Ethanol