Peripheral injection of arginine8-vasopressin increases Fos in specific brain areas.
Learned behaviors and tolerance to ethanol can be maintained by peripheral injection of arginine8-vasopressin (vasopressin) under conditions in which they would otherwise be lost. However, the sites of this action in the brain have not been clearly identified. Using a polyclonal antibody raised against Fos and Fos-like proteins, we have demonstrated increases in immunoreactive Fos and Fos-like proteins in the suprachiasmatic, supraoptic and paraventricular nuclei of the hypothalamus, and lesser increases in piriform cortex and amygdala, of the rat 2 h after a s.c. injection of vasopressin. Our results suggest that the exogenous vasopressin may exert its central action by activating a cellular immediate early gene in specific brain regions.
Department of Pharmacology, University of Toronto, Ontario, Canada.
P H
PH
Wu
A J
AJ
Lança
J F
JF
Liu
C F
CF
Man
H
H
Kalant
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D017781:Genes, Immediate-Early / Q000187:drug effects; D007031:Hypothalamus / Q000276:immunology; D007150:Immunohistochemistry; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000906:Antibodies; D016760:Proto-Oncogene Proteins c-fos; D001127:Arginine Vasopressin