[A study of interleukin-6 and soluble interleukin-6 receptors during pregnancy and delivery].
In order to investigate the correlation between uterine contraction and Interleukin-6 (IL-6), we studied the effects of the prenatal course and uterine contraction on IL-6 and the soluble Interleukin-6 receptor (sIL-6R) concentration in human amniotic fluid. We also determined the effects of IL-6 on the permeability of the human amnion cell monolayer. The results were as follows: 1) The level of IL-6 at full term delivery was significantly higher than that at premature delivery. 2) The level of IL-6 without uterine contraction was significantly (p < 0.05) higher than that with uterine contraction. 3) The mean sIL-6R value at full term delivery was 1.28 +/- 0.21 ng/ml. There was no correlation between sIL-6R and the prenatal course. 4) IL-6 enhanced permeability in the human amniotic cell monolayer. This effect of Il-6 was concentration dependent and time dependent. These results show that uterine contractions increased the IL-6 concentration in human amniotic fluid, and suggest that uterine contraction enhanced the permeability of the human amniotic cell in vivo.
Ishizaki
S
S
First Department of Obstetrics and Gynecology, Toho University School of Medicine, Tokyo.
D000653:Amniotic Fluid / Q000166:cytology / Q000378:metabolism*; D015703:Antigens, CD / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D007743:Labor, Obstetric / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*; D018123:Receptors, Interleukin / Q000378:metabolism*; D019947:Receptors, Interleukin-6; D012995:Solubility; D014590:Uterine Contraction
D015703:Antigens, CD; D015850:Interleukin-6; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6