[The assessment of basement membrane in cancer of the floor of the mouth and larynx].
An immunohistochemical method using a monoclonal antibody to collagen type IV was employed to assess the basement membrane (BM) deposition in 36 cases of cancer of the floor of the mouth and in 32 cases of cancer of the larynx. The BM deposition was scored as extensive or limited, and compared to degree of histologic differentiation of tumor and to 3-year survival rate for patient and regional metastasis. There were 42 cases with extensive and 26 with limited BM deposition between cancer of the floor of the mouth and cancer of the larynx were found. Statistical analysis did not show a relationship between BM deposition of either cancer and the survival of patients or with regional metastasis, however a little better results was obtained for patients with extensive BM deposition. Poorly differentiated carcinoma of the floor of the mouth had a tendency to limited BM deposition.
Dobroś
W
W
Kliniki Otolaryngologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Farmer
E R
ER
Price
J C
JC
D000911:Antibodies, Monoclonal; D001485:Basement Membrane / Q000473:pathology* / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure*; D007830:Larynx / Q000473:pathology* / Q000648:ultrastructure*; D009060:Mouth Floor / Q000473:pathology* / Q000648:ultrastructure*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate
D000911:Antibodies, Monoclonal
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