Homeostatic derangement in the CBA rodent host during the growth of the CaNT tumor.
The purpose of this study was to evaluate some indicators of the pathogenesis of cancer cachexia in which the growth of the CaNT tumor markedly alters the metabolism and induces measurable biochemical changes of the host. An increase of hexokinase and lactate dehydrogenase activities with tumor volume, coupled with the decline of oxygen consumption are shown in this work. Furthermore changes in the mean spin lattice and spin-spin relaxation time values of the tumor provide additional information of the abnormal cellular spatial and metabolic relationships that exists within the tumor. In the liver of the host, the augmentation of the oxygen uptake and specific activities of lactate dehydrogenase and fructose-1,6-diphosphatase shown in this work, reflecting an increase in the glucose metabolism rate and thus, energy expenditure of the host. This may envisage some correlation with the onset of biochemical changes in the homeostatic derangement in the host during the fast growth of the tumor.
Research Institute for Medical Biophysics, Medical Research Council, Tygerberg, South Africa.
N
N
De Villiers
A P
AP
Burger
H
H
Smith
D
D
Szeinfeld
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002100:Cachexia / Q000209:etiology*; D004734:Energy Metabolism; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D006706:Homeostasis; D007672:Kidney Cortex / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption
D006593:Hexokinase; D006597:Fructose-Bisphosphatase; D005947:Glucose