Ki-1 (CD30) positive anaplastic large cell lymphoma of T-cell phenotype developing in association with long-standing tuberculous pyothorax: report of a case with detection of Epstein-Barr virus genome in the tumor cells.
We report a case of CD30 positive anaplastic large cell lymphoma of T-cell phenotype developing in association with long-standing tuberculous pyothorax. Phenotypic analysis showed CD1a-, CD2+, CD3+, CD4+, CD5-, CD8-, CD10-, CD19-, CD20 +/-, CD21-, CD25-, CD56-, T-cell receptor (TCR) alpha/beta antigens-, and HLA-DR+ phenotype. Neither rearrangement of TCR beta and gamma chain genes or of immunoglobulin heavy chain gene was detected in DNA extract from fresh material. The lymphoma cells were also shown to express the latent membrane protein-1 and the Epstein-Barr virus (EBV)-encoded nuclear antigen-2 by immunohistochemistry and EBV-encoded small RNAs by in situ hybridization.
Department of Pathology, Aichi Cancer Center Hospital, Nagoya, Japan.
S
S
Nakamura
Y
Y
Sasajima
T
T
Koshikawa
K
K
Kitoh
M
M
Kato
R
R
Ueda
S
S
Mori
T
T
Suchi
D000368:Aged; D004654:Empyema, Tuberculous / Q000150:complications / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000473:pathology* / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000473:pathology
D012367:RNA, Viral