Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein.
Two recently developed vaccine--one based on synthetic peptide and one based on recombinant capsid protein--fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology ( > 98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants. This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 micrograms of conjugated peptide or 3 micrograms of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.
Institute for Animal Science and Health (ID-DLO), Lelystad, The Netherlands.
J P
JP
Langeveld
S
S
Kamstrup
A
A
Uttenthal
B
B
Strandbygaard
C
C
Vela
K
K
Dalsgaard
N J
NJ
Beekman
R H
RH
Meloen
J I
JI
Casal
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D002213:Capsid / Q000235:genetics / Q000276:immunology; D036022:Capsid Proteins; D028301:Feline Panleukopenia Virus / Q000276:immunology*; D008907:Mink / Q000821:virology*; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D010322:Parvoviridae Infections / Q000517:prevention & control* / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000276:immunology*; D010455:Peptides / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D036022:Capsid Proteins; D010455:Peptides; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; C095548:capsid protein VP2, parvovirus B19