Lymphoepithelioma-like carcinoma of the vulvar region.
A case of lymphoepithelioma-like carcinoma of the vulvar region is described. Histologically, the tumour was similar to lymphoepithelioma of the nasopharynx but was Epstein-Barr virus negative. Infiltrating lymphocytes were predominantly T-cells, but also included some B-cells. Immunohistochemical stains showed positivity in tumour cells for cytokeratins but negativity for neuroendocrine markers, the melanoma-associated antigen. HMB45 and leucocyte common antigen. We conclude that the tumour histologically resembles lymphoepithelioma of the nasopharynx and lymphoepithelioma-like carcinomas of the skin, and has no relation to prior infection with the Epstein-Barr virus.
Department of Obstetrics and Gynaecology Randers Hospital, Denmark.
S M
SM
Axelsen
I M
IM
Stamp
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006566:Herpesviridae Infections / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D008875:Middle Aged; D014412:Tumor Virus Infections / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology*