A case of acute dapsone poisoning: toxicological data and review of the literature.
A case of nonfatal, acute poisoning following the ingestion of an undetermined amount of dapsone (DDS) in a 49-year-old woman is presented. The clinical features were dyspnea and deep cyanosis. Methemoglobinemia was 39.0% on admission. DDS was identified and quantitated in blood samples taken on the third day (sample A) and fifth day (sample B) in the hospital using a high-performance liquid chromatographic technique with diode-array detection. DDS concentrations were 26.99 and 8.40 micrograms/mL in samples A and B, respectively. Results are discussed in the light of an extensive review of the literature (1950-1993) available on DDS poisonings.
Institut de Médecine Légale, Strasbourg, France.
A
A
Tracqui
A M
AM
Gutbub
P
P
Kintz
P
P
Mangin
D002851:Chromatography, High Pressure Liquid; D003490:Cyanosis / Q000139:chemically induced*; D003622:Dapsone / Q000097:blood / Q000506:poisoning*; D004417:Dyspnea / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000097:blood / Q000506:poisoning*; D008875:Middle Aged
D007917:Leprostatic Agents; D003622:Dapsone