A case of ovarian serous adenocarcinoma suggestive of transformation to an AFP-producing tumor during chemotherapy.
Ovarian serous adenocarcinoma with AFP production is very rare. A case involving a 66-year-old woman with an elevated serum AFP level without detectable hepatic involvement. AFP-positive cells were seen in the tumor at the second surgery. Fifty-seven percent of serum AFP from the patient bound Con A, whereas 43% did not. Similarly, 54% of the tumor fluid also bound Con A. These suggest that the serum AFP was similar to that of gastrointestinal tumors and yolk-sac tumors.
Department of Obstetrics and Gynecology, Kurume University, Japan.
A
A
Kataoka
T
T
Nishida
T
T
Sugiyama
M
M
Yakushiji
D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D018284:Cystadenocarcinoma, Serous / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000032:analysis / Q000378:metabolism*
D018394:CA-125 Antigen; D000509:alpha-Fetoproteins