The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor.
Kimble
E
E
Research Department, Ciba-Geigy Corp., Summit, NJ 07901, USA.
Hadala
J
J
Ludewig
R
R
Peters
P
P
Greenberg
G
G
Xiao
G
G
Guida
W
W
McQuire
L
L
Simon
P
P
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007288:Inosine / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors* / Q000172:deficiency; D013601:T-Lymphocytes / Q000187:drug effects
D001593:Benzyl Compounds; D004791:Enzyme Inhibitors; C082660:9-benzyl-9-deazaguanine; D007288:Inosine; D006147:Guanine; D011683:Purine-Nucleoside Phosphorylase