Serum TNF-alpha, sCD8 and sIL-2R levels in childhood tuberculosis.
In this study we have determined the serum tumor necrosis factor-alpha (TNF-alpha), soluble CD8 (sCD8) and soluble interleukin-2 receptor (sIL-2R) levels in children with active pulmonary tuberculosis (n = 66) and healthy controls (n = 20). Measurable serum TNF-alpha levels were detected in nine of 86 children (10.5%), all of whom belonged to the group with active disease. Serum sCD8 and sIL-2R determinations revealed a significant difference between the group with active pulmonary tuberculosis and the controls (p < 0.05). Deeper insight into the involvement of cytokines and T cells will provide a better understanding
Barlan
I B
IB
Dept. of Pediatrics, Marmara Univ. Hospital, Istanbul, Turkey.
Başaran
M M
MM
Bakir
M
M
Tükenmez
F
F
Bekiroğlu
N
N
D000293:Adolescent; D016827:CD8 Antigens / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D016827:CD8 Antigens; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha