Absence of evidence for mutagenicity of alcoholic beverages: an analysis of hprt mutant frequencies in 153 normal humans.
A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors were classified into four groups, including total abstainers (n = 18); those who consumed less than the Royal College of Physicians guideline (men, 21 units; women, 14 units) (n = 113); those who consumed more than the guideline value (n = 12); and designated alcohol-dependent subjects (n = 10). No significant difference in mutant frequency between the four groups was found, nor was an overall correlation between alcohol consumption and mutant frequency seen.
Cole
J
J
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.
Green
M H
MH
D000079:Acetaldehyde / Q000633:toxicity; D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics; D000434:Alcoholic Beverages / Q000633:toxicity*; D000437:Alcoholism / Q000235:genetics; D001711:Biotransformation; D000431:Ethanol / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008297:Male; D009152:Mutagenicity Tests; D012907:Smoking / Q000235:genetics; D013695:Temperance
D000431:Ethanol; D007041:Hypoxanthine Phosphoribosyltransferase; D000079:Acetaldehyde