Unidirectional valve patch for repair of cardiac septal defects with pulmonary hypertension.
BACKGROUND
Congenital septal defects with a large left-to-right shunt often cause pulmonary hypertension, which complicates surgical repair of the defects.


METHODS
Twenty-four patients with congenital cardiac septal defects and severe pulmonary hypertension had operation to close the septal defect using a unidirectional valve patch during a 3-year period. The ratio of systolic pulmonary artery pressure to systolic arterial blood pressure was near to or more than 1.0 in all patients.


RESULTS
Two patients died in the hospital after operation, and there have been no deaths during intermediate term follow-up. Mean pulmonary artery pressure decreased from 80 +/- 12 mm Hg to 56 +/- 18 mm Hg. The ratio of pulmonary artery pressure to systemic arterial pressure dropped from 1.1 +/- 0.1 mm Hg to 0.7 +/- 0.1 mm Hg. The unidirectional valve patch functioned allowing right to left shunting in 4 patients with a systolic pulmonary artery pressure more than systolic arterial blood pressure immediately after closure of a septal defect. The patch sealed or was effectively closed by the third postoperative day. There was impressive improvement in symptoms and exercise tolerance after operation during the 3-month to 3-year (mean, 1.1 year) follow-up period.


CONCLUSIONS
The unidirectional valve patch is useful for management of patients having operation to close cardiac septal defects in the presence of severe pulmonary hypertension.
Zhou
Q
Q
Department of Cardiac Surgery, Beijing Heart, Lung and Blood Vessel Medical Center, People's Republic of China.
Lai
Y
Y
Wei
H
H
Song
R
R
Wu
Y
Y
Zhang
H
H
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D005080:Exercise Test; D005500:Follow-Up Studies; D006343:Heart Septal Defects / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000379:methods; D017052:Hospital Mortality; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D011652:Pulmonary Circulation; D011669:Pulmonary Wedge Pressure; D013599:Systole; D016896:Treatment Outcome