[Pulmonary metabolism of beta-endorphin in asthmatic patients in asymptomatic periods and after bronchospasm induced by methacholine].
Blood concentration of endogenous beta-endorphines can change during the clinical evolution of chronic bronchopneumopathies. The authors assessed the beta-endorphine concentrations in the pulmonary arterial and systemic arterial blood in 8 asthmatic patients during a symptom-free period and after methacholine-induced bronchospasm. The beta-endorphine analysis was performed in duplicate dor each sample, by means of a RIA assay. There is not difference in the systemic arterial blood concentration of beta-endorphines between asthmatic patients and normal subjects. Furthermore, there is no change in the beta-endorphine blood concentration during the passage through the pulmonary tissue after methacoline-induced bronchospasm.
Dipartimento di Medicina Interna-Università degli Studi di Genova.
G
G
Bottino
G
G
Antognozzi
R
R
Degrandi
C
C
Augeri
G
G
Bogliolo
P
P
Zoccali
D000328:Adult; D001249:Asthma / Q000378:metabolism*; D001986:Bronchial Spasm / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D008688:Methacholine Compounds; D008875:Middle Aged; D001615:beta-Endorphin / Q000097:blood*
D008688:Methacholine Compounds; D001615:beta-Endorphin
Metabolismo polmonare delle beta-endorfine in soggetti asmatici asintomatici e dopo broncospasmo indotto con metacolina.