Effect of acute and chronic glutathione depletion on renal function in the rat.
Renal function was evaluated in normal and acid-loaded rats following acute and chronic depletion of glutathione (GSH) by buthionine sulfoximine (BSO). Creatinine clearance and fractional excretion of electrolytes were normal. There was no acidification or concentration defect detected in animals with acute or chronic GSH depletion.
Section of Nephrology, Cook County Hospital, Hektoen Institute for Medical Research, University of Illinois at Chicago 60612, USA.
S L
SL
Garber
J A
JA
Arruda
G
G
Dunea
D000643:Ammonium Chloride / Q000378:metabolism; D000818:Animals; D000963:Antimetabolites / Q000633:toxicity*; D019328:Buthionine Sulfoximine; D003404:Creatinine / Q000652:urine; D004573:Electrolytes / Q000652:urine; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005978:Glutathione / Q000172:deficiency / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D000963:Antimetabolites; D004573:Electrolytes; D004791:Enzyme Inhibitors; D000643:Ammonium Chloride; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D003404:Creatinine; D005978:Glutathione