Expression of S100 protein in the vestibular nuclei during compensation of unilateral labyrinthectomy symptoms.
In adult guinea pigs, unilateral labyrinthine lesions were inflicted by chloroform injections into the middle ear. Immunoreactivity for S100 protein (S100) in the vestibular nuclei was studied during compensation of lesion-induced postural asymmetry symptoms, i.e., nystagmus, asymmetrical head position. 1 h after unilateral labyrinthectomy, increased levels of astroglial S100 immunoreactivity were found in the superior vestibular nucleus and in the medial/lateral vestibular nucleus border region on the side contralateral to the deafferentation. Bilaterally, the astrocytic S100 immunoreaction increased in the lateral vestibular nuclei around Deiters neurons. Maximal expression of S100 was noted 3 h after the lesion. Subsequently, it diminished. Our data reveal that transsynaptically altered neuronal activity induces an astrocytic reaction which provides increased levels of S100 to the local neuropil. Calcium and zinc binding S100 proteins may play a functional role for the neuroplasticity during vestibular compensation.
Department of Clinical Anatomy and Developmental Neurobiology, Universität Göttingen, Germany.
M
M
Rickmann
J R
JR
Wolff
D L
DL
Meyer
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D007758:Ear, Inner / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006168:Guinea Pigs; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D017933:Peripheral Nervous System / Q000502:physiology; D011485:Protein Binding; D009418:S100 Proteins / Q000032:analysis*; D014726:Vestibular Nuclei / Q000737:chemistry*; D015032:Zinc / Q000378:metabolism*
D002352:Carrier Proteins; D009418:S100 Proteins; D015032:Zinc; D002118:Calcium