Supported membranes: scientific and practical applications.
Scientific and practical applications of supported lipid-protein bilayers are described. Membranes can be covalently coupled to or separated from solids by ultrathin layers of water or soft polymer cushions. The latter systems maintain the structural and dynamic properties of free bilayers, forming a class of models of biomembranes that allow the application of a manifold of surface-sensitive techniques. They form versatile models of low-dimensionality complex fluids, which can be used to study interfacial forces and wetting phenomena, and enable the design of phantom cells to explore the interplay of lock-and-key forces (such as receptor-ligand binding) and universal forces for cell adhesion. Practical applications are the design of (highly selective) receptor surfaces of biosensors on electrooptical devices or the biofunctionalization of inorganic solids.
Physik Department E22 (Biophysics Laboratory) Technische Universität München, Garching, Germany.
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Sackmann
D015374:Biosensing Techniques; D002448:Cell Adhesion; D004058:Diffusion; D004563:Electrochemistry; D008024:Ligands; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D011108:Polymers; D011506:Proteins / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000378:metabolism; D013499:Surface Properties; D013816:Thermodynamics
D008024:Ligands; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D011108:Polymers; D011506:Proteins; D011956:Receptors, Cell Surface