M-caveolin, a muscle-specific caveolin-related protein.
Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells. The best-characterised caveolar protein is the integral membrane protein, VIP21-caveolin. We now describe a novel homologue of VIP21-caveolin, M-caveolin, which is expressed exclusively in muscle. M-caveolin was shown to be expressed in differentiated myotubes but not myoblasts. Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin. M-caveolin may play a specialised role in the caveolae of muscle cells.
European Molecular Biology Laboratory, Heidelberg, Germany.
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D051242:Caveolin 1; D051244:Caveolin 3; D022461:Caveolins; D018076:DNA, Complementary / Q000302:isolation & purification; D015870:Gene Expression; D015723:Gene Library; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry; D051379:Mice; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000737:chemistry* / Q000235:genetics; D018482:Muscle, Skeletal / Q000737:chemistry; D009132:Muscles / Q000737:chemistry*; D009928:Organ Specificity; D051381:Rats; D017385:Sequence Homology; D014162:Transfection
C495540:CAV1 protein, human; C495541:Cav1 protein, mouse; C495537:Cav1 protein, rat; C495548:Cav3 protein, mouse; C495549:Cav3 protein, rat; D051242:Caveolin 1; D051244:Caveolin 3; D022461:Caveolins; D018076:DNA, Complementary; D008565:Membrane Proteins; D009124:Muscle Proteins