DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.
Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.
Jackson
S P
SP
Wellcome/CRC Institute, Cambridge, UK.
Jeggo
P A
PA
D000818:Animals; D004247:DNA; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D015321:Gene Rearrangement; D005816:Genetic Complementation Test; D008322:Mammals / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011995:Recombination, Genetic
D004268:DNA-Binding Proteins; D004247:DNA; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases