Ultrasound-guided microwave thermotherapy on a VX-2 carcinoma implanted in rabbit kidney.
A temperature greater than 60 degrees C was maintained for 60 s within a 5-mm radius of a microwave electrode implanted in a rabbit kidney using 2450 MHz at 100 W for 30 s. Histological examination revealed complete coagulation necrosis in that area. VX-2 cells were inoculated into the kidneys of 10 rabbits. One week later, five rabbits received ultrasound-guided microwave thermotherapy, and the remaining five rabbits received no treatment. All rabbits with microwave thermotherapy had a complete response to treatment while all rabbits without therapy died of cancer within 6 weeks of the VX-2 implantation. These results indicate that ultrasound-guided microwave thermotherapy has the potential of being a nephron-salvaging treatment for small renal tumors.
Kigure
T
T
Department of Urology, Akita University School of Medicine, Japan.
Harada
T
T
Yuri
Y
Y
Satoh
Y
Y
D000818:Animals; D001831:Body Temperature; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D008839:Microelectrodes; D008872:Microwaves; D009368:Neoplasm Transplantation; D011817:Rabbits; D014407:Tumor Cells, Cultured; D014464:Ultrasonic Therapy; D014463:Ultrasonography