[Role of low-frequency neuronal activity in the medulla in the regulation of the cardiovascular system].
We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55%) units. The same rhythmicity was found in SAP variability in 25 of 45 (55%) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71%) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.
Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale L Sacco, Università degli Studi, Milano.
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Montano
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Barman
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Gnecchi-Ruscone
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Porta
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Lombardi
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Malliani
D000704:Analysis of Variance; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002415:Cats; D003655:Decerebrate State; D004569:Electroencephalography; D008526:Medulla Oblongata / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011903:Raphe Nuclei / Q000502:physiology*
Evidenza di un ritmo a bassa frequenza nella scarica di singoli neuroni del tronco encefalico coinvolti nella regolazione del sistema cardiovascolare.