[Allogeneic transplantation of stem cells--procedure and biological aspects].
The biological challenges to be overcome for allogeneic stem cell transplantation to succeed include: 1, eradication of the patient's malignant tissue by effective, yet tolerable cytoreductive preconditioning; 2, suppression of the patient's immunocompetence to prevent graft rejection; 3, a stem cell graft of adequate haematopoietic capacity must be obtained from a donor of acceptable histocompatibility, and transferred to the patient; and 4, since the graft also contains lymphocytes mediating antirecipient donor alloimmunity, posttransplant immunosuppressive therapy is required to prevent, and sometimes to treat graft-versus-host disease. Basic immunobiological and clinical aspects, and methods used in stem cell transplantation are reviewed in the article.
Kirurgisk avdeling B, Rikshospitalet, Oslo.
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Albrechtsen
D006084:Graft Rejection / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000517:prevention & control; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents
Allogen transplantasjon av stamceller--prosedyre og biologiske forutsetninger.