Protection of CCL4-induced liver damage in rats by some calcium channel blockers.
Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels serun aspartate aminotrans ferase (AST), alanine aminotransferase (AIT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Nitrendipine, nimodipine and nisoldipine (1 mg/100 g of rat, ip) significantly reduced these elevated levels of AST, AIT and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in nitrendipine, nimodipine and nisoldipine pre-treated animals as observed macroscopically and histologically.
Department of Pharmacology, Medical College, Rohtak.
J
J
Singh
A H
AH
Kaur
S K
SK
Mathur
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009336:Necrosis / Q000473:pathology; D009553:Nimodipine / Q000627:therapeutic use; D015737:Nisoldipine / Q000627:therapeutic use; D009568:Nitrendipine / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000097:blood
D002121:Calcium Channel Blockers; D015737:Nisoldipine; D009553:Nimodipine; D009568:Nitrendipine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase