Staphylococcal enterotoxin is a bovine T cell superantigen.
Different isoforms of soluble staphylococcal enterotoxins (SE): SEB, SEC-1 and SEC-2, were shown to stimulate bovine T cell proliferation, expression of cytokine messages, and IgG production. Intact metabolic function of APC was not required since peripheral blood mononuclear cells (PBMC), UV-irradiated prior to or following incubation with SE, were both capable of presenting SE, while PBMC treated with MAbs against MHC II lost the ability to stimulate T cell proliferation. SE caused approximately two fold increase of CD4+, and CD8+ T cells, but not MHC II+ APC or B cells. This model system suggests that SE transduces not only T cell activation signal, but also a non-proliferative signal for primary B cells to produce polyclonal IgG. We hypothesize that enterotoxin virulence may be in part due to its effect on activating the immune system.
Schmaltz
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R
Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, USA.
Bhogal
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B
Wang
Y Y
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Petro
T
T
Chen
S S
SS
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D008213:Lymphocyte Activation; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013552:Swine / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004768:Enterotoxins; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G; D007376:Interleukin-2; D018089:Superantigens; C031818:enterotoxin B, staphylococcal; C034959:enterotoxin C, staphylococcal; D007371:Interferon-gamma