Immunomodulatory effects of Maharishi Amrit Kalash 4 and 5 in mice.
To evaluate the immunomodulatory effects of two kinds of Ayurvedic food supplements (Maharishi Amrit Kalash 4 and Maharishi Amrit Kalash 5, M-4 and M-5), superoxide anion (O2-) production of peritoneal macrophages and the response of spleen cells to concanavalin A (Con A) were examined in mice given an aqueous emulsion of M-4 and M-5 p.o. at doses of 50 and 100 mg/kg for 10 days. O2- production of peritoneal macrophages in the M-5 (50 mg/kg)-treated group was significantly higher than that in the control group. The indices of stimulation of spleen cells by Con A were significantly (3 to 4 times) higher in groups treated with M-4 and M-5 at all doses than in the control group. These results indicate that M-4 enhances lymphocyte responsiveness and M-5 enhances not only lymphocyte responsiveness but also macrophage function. It is also suggested in this study that M-4 and M-5 have mitogenic effects on lymphocytes.
Department of Hygiene, Gifu University School of Medicine, Japan.
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Inaba
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Sugiura
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Iwata
D000276:Adjuvants, Immunologic; D000818:Animals; D003208:Concanavalin A / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D013154:Spleen / Q000166:cytology; D013481:Superoxides / Q000378:metabolism*
D000276:Adjuvants, Immunologic; D003208:Concanavalin A; D013481:Superoxides