Maternal origin of extra haploid set of chromosomes in third trimester triploid fetuses.
Twenty-six highly polymorphic markers were used to determine the origin of the extra haploid chromosome set in 6 triploid fetuses of type II phenotype. All had reached the third trimester of pregnancy. The extra set was maternal in origin in all cases, supporting previous research indicating longer in utero survival of maternally-derived triploid fetuses. These findings provide evidence for an instance of genomic imprinting in humans.
Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
E
E
Dietzsch
M
M
Ramsay
A L
AL
Christianson
B D
BD
Henderson
T J
TJ
de Ravel
D000328:Adult; D002869:Chromosome Aberrations / Q000196:embryology / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D005819:Genetic Markers; D018392:Genomic Imprinting; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008540:Meiosis; D009866:Oogenesis; D011123:Polyploidy; D011247:Pregnancy
D005819:Genetic Markers