Transient myocardial dysfunction in a child with salicylate toxicity.
Aspirin overdose may result in acid-base disturbances, electrolyte abnormalities, pulmonary edema, chemical hepatitis, seizures, and mental status alteration, but myocardial depression has not been reported following aspirin overdose in children. In addition to these more typical features, the 13-month-old boy reported here developed clinical, radiographic, and echocardiographic evidence of myocardial impairment with pulmonary edema and moderately severe global left ventricular dysfunction (estimated shortening fraction of 23%). Complete resolution of the myocardial dysfunction was demonstrated on follow-up echocardiography as the child recovered from the aspirin intoxication. This case suggests that myocardial dysfunction can occur as a result of toxic aspirin ingestion, and that it may contribute to salicylate-induced pulmonary edema.
Ralston
M E
ME
Department of Pediatrics, Naval Medical Center, San Diego, California 92134-5000, USA.
Pearigen
P D
PD
Ponaman
M L
ML
Erickson
L C
LC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D001241:Aspirin / Q000506:poisoning*; D006332:Cardiomegaly / Q000139:chemically induced / Q000175:diagnosis; D004452:Echocardiography; D006801:Humans; D007223:Infant; D008297:Male; D008944:Mitral Valve Insufficiency / Q000139:chemically induced / Q000175:diagnosis; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000175:diagnosis; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000175:diagnosis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin