Effects of a component of green tea on the proliferation of vascular smooth muscle cells.
The effects of a component of green tea on the proliferation of smooth muscle cells were measured in terms of [3H]thymidine uptake. When green tea tannin mixture was added to the medium of cultured smooth muscle cells, it suppressed the proliferation of the cells dose-dependently. Similarly to the effects of the green tea tannin mixture, (-)-epigallocatechin 3-O-gallate, its main ingredient, had an inhibitory effect on smooth muscle cell proliferation at a low concentration. (-)-Epicatechin 3-O-gallate was also an effective component. Among four types of gallate-free tannin, (-)-epigallocatechin, (-)-epicatechin, and (+)-catechin showed significant dose-dependent inhibition of smooth muscle cell proliferation. However, caffeine and theanine were found to have no such action.
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
T
T
Yokozawa
H
H
Oura
H
H
Nakagawa
S
S
Sakanaka
M
M
Kim
D000818:Animals; D002392:Catechin / Q000737:chemistry; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D010936:Plant Extracts; D013662:Tea; D014316:Tritium; D002392:Catechin; D013936:Thymidine