Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.
Department of Physiology and Internal Medicine, Ohio State University, Columbus 43210, USA.
S M
SM
Jhiang
J E
JE
Sagartz
Q
Q
Tong
J
J
Parker-Thornburg
C C
CC
Capen
J Y
JY
Cho
S
S
Xing
C
C
Ledent
D000818:Animals; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D029721:Drosophila Proteins; D018628:Gene Dosage; D015870:Gene Expression; D051379:Mice; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
D029721:Drosophila Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C494999:Ret protein, mouse