Antecedents and consequences of negative life events in adulthood: a longitudinal study.
OBJECTIVE
This study investigated whether negative life events affected subjects' long-term physical and mental health.


METHODS
One hundred thirteen normal college men completed biennial follow-up questionnaires from age 26 until age 62. At age 62 they retrospectively assessed 16 major negative life events with a self-report checklist. A blind rater read each man's complete records over the 35 years and completed the same checklist prospectively. The men had independent physical examinations at age 65.


RESULTS
It was demonstrated that negative life events affect men's psychological health more than their physical health. The correlation of negative life events with physical health was so low that no significant relationship between the two variables could be established. Negative life events were significantly associated with affective spectrum disorder and its relevant indicators. Further, the Cox proportional hazards model revealed that negative life events, family history of depression, and psychosocial stability during the college years were independent and statistically significant predictors of depression.


CONCLUSIONS
This study supports the widely held belief that biological factors (heredity), psychological factors (unstable personality), and social factors (negative life events) are all etiologically related to depression.
Division of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
X J
XJ
Cui
G E
GE
Vaillant
D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology*; D003866:Depressive Disorder / Q000209:etiology; D005500:Follow-Up Studies; D005823:Genetics; D006304:Health Status; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology; D010551:Personality; D010555:Personality Inventory; D011336:Probability; D016016:Proportional Hazards Models; D012189:Retrospective Studies