Major gene analysis for diseases and disorders of complex etiology.
Genetic analysis of complex diseases is undergoing a paradigm shift as the DNA technology and computational resources for analysis become more precise. In this review we compare the old paradigm for genetic disease analysis with the new, more powerful and efficient methods, which rely on the application of genetically linked markers. To illustrate the utility of the new approach, we apply it in the study of ankylosing spondylitis.
Amos
C I
CI
Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
Rubin
L A
LA
D004247:DNA / Q000235:genetics; D004843:Epistasis, Genetic; D030342:Genetic Diseases, Inborn / Q000209:etiology / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005821:Genetic Techniques; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D013167:Spondylitis, Ankylosing / Q000209:etiology / Q000235:genetics
D005819:Genetic Markers; D015796:HLA-B27 Antigen; D004247:DNA