[Various immunohistochemical markers of precancer and variants of prostate cancer].
The prostates of 45 patients with benign hyperplasia, precancer and carcinoma of the prostate were studied using histochemical and immunohistochemical methods. The correlation between the expression of the prostatic specific antigen and prostatic acid phosphatase according to the histological type of tumor and the level of differentiation of the prostatic intraepithelial neoplasia (PIN) was established. PIN is connected with acinar glandular epithelium. It occupies an intermediate position between well differentiated non-invasive carcinoma and large-acinar carcinoma. Cytospecificity of these antigens may be used as markers of premalignant lesions for differential diagnosis of precancerous processes in the prostate. Immunohistochemical properties of PIN may be used for revealing groups of a high risk.
Romanenko
A M
AM
Vorob'eva
L R
LR
D000135:Acid Phosphatase / Q000032:analysis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D016022:Case-Control Studies; D004848:Epithelium / Q000276:immunology; D000939:Epitopes; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009024:Morphogenesis; D011230:Precancerous Conditions / Q000378:metabolism*; D011467:Prostate / Q000201:enzymology*; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000201:enzymology / Q000473:pathology; D012307:Risk Factors
D014408:Biomarkers, Tumor; D000939:Epitopes; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen
Nekotorye immunokhistokhimicheskie markery predraka i razlichnykh variantov raka predstatel'noĭ zhelezy.