Involvement of sigma 1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats.
The effects of the stereoisomers of N-allylnormetazocine (SKF-10,047) on the hippocampal cholinergic functions were compared in rats. A putative sigma 1 receptor agonist, (+)-SKF-10,047, elicited an increase of hippocampal extracellular acetylcholine level and anti-amnesic effect against scopolamine-induced memory dysfunctions in rats. These phenomena were not produced by (-)-SKF-10,047, and were reversed by haloperidol, a putative sigma 1 receptor antagonist. Such stereoselectivity and antagonism imply an involvement of sigma 1 receptors in these (+)-SKF-10,047-stimulated hippocampal cholinergic functions.
Central Research Laboratories, Santen Pharmaceutical Co., Ltd., Osaka, Japan.
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Matsuno
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Senda
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Kobayashi
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Mita
D000109:Acetylcholine / Q000502:physiology*; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D013268:Stimulation, Chemical; D009435:Synaptic Transmission / Q000187:drug effects*
D018727:Muscarinic Antagonists; D017480:Receptors, sigma; C012134:SK&F 10047; D012601:Scopolamine; D010620:Phenazocine; D006220:Haloperidol; D000109:Acetylcholine