Discontinuation of neuroleptics in community-dwelling individuals with mental retardation and mental illness.
Many individuals with mental retardation and mental illness who are on neuroleptics can have the dose reduced or discontinued. A recent study, however, suggests that individuals with psychosis not only may be difficult to discontinue from neuroleptics but also may require an increased neuroleptic dose. The current study is a retrospective chart review. Individuals were followed for 12 months postneuroleptic discontinuation. Individuals with a "psychotic" disorder were significantly more likely to be restarted on neuroleptics at 3 months and 12 months. A logistic regression failed to reveal any psychotic symptoms that predicted resumption on neuroleptics. An absent history of delusions, however, was significantly associated with remaining neuroleptic-free at 3 months.
University of Pittsburgh, Department of Psychiatry, USA.
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Pary
D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004363:Drug Utilization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology / Q000534:rehabilitation*; D008297:Male; D001523:Mental Disorders / Q000523:psychology / Q000534:rehabilitation*; D008875:Middle Aged; D010414:Pennsylvania; D011618:Psychotic Disorders / Q000523:psychology / Q000534:rehabilitation; D012008:Recurrence; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000209:etiology
D014150:Antipsychotic Agents