[Experimental and clinical trial of degradable starch microspheres (DSM) in treatment of hepatic neoplasm: Part 2. Clinical study].
Hepatic chemotherapy with DSM was performed in 63 patients (45 patients with hepatocellular carcinoma and 18 patients with liver metastases). Two patients showed complete response and 12 patients showed partial response. The greater the blockade of arterial blood flow, the better the clinical response seemed. Analysis of changes in CT images after hepatic chemotherapy with DSM revealed that, in addition to enhancement of the effect of the anticancer drugs by blockade of blood flow, DSM also had an ischemic effect. In conclusion, DSM used together with anticancer drug may improve the therapeutic effects.
Department of Radiology, Osaka City University, Medical School.
T
T
Yamada
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000628:therapy*; D008863:Microspheres; D008937:Mitomycins / Q000008:administration & dosage; D013213:Starch / Q000008:administration & dosage*
D008937:Mitomycins; D004317:Doxorubicin; D013213:Starch