Native-like and structurally characterized designed alpha-helical bundles.
A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.
DuPont Merck Pharmaceutical Company, Wilmington, USA.
S F
SF
Betz
J W
JW
Bryson
W F
WF
DeGrado
D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D012996:Solutions
D012996:Solutions