Safety and pharmacokinetics of iotrolan in hysterosalpingography. Retention and irritability compared with Lipiodol.
OBJECTIVE
The authors compared the safety and pharmacokinetics of Iotrolan (water-soluble) in hysterosalpingography (HSG) with those of Lipiodol (oil-soluble).


METHODS
Iotrolan and Lipiodol were administered intraperitoneally at doses of 100 mg iodine/kg to female rabbits. Retention in the body was investigated by x-ray imaging, plasma kinetics, and urinary and fecal excretion. Irritability in the abdomen was investigated by histologic examination.


RESULTS
Iotrolan was entirely excreted into the urine within 2 days after administration. Conversely, Lipiodol was excreted into the urine, had a half-life of 50 days, and was retained for more than 21 days in the abdomen. Iotrolan induced no inflammatory reaction in the abdomen, whereas Lipiodol induced a marked abdominal inflammatory reaction, including granuloma formation. Iotrolan had no effect on iodine concentration in the thyroid; Lipiodol increased iodine concentration significantly.


CONCLUSIONS
Iotrolan, which is a water-soluble and nonionic dimeric contrast medium, has potential greater safety for use in HSG than Lipiodol.
Miyamoto
Y
Y
Research Department, Nihon Schering K.K., Osaka, Japan.
Tsujimoto
T
T
Iwai
K
K
Ishida
K
K
Uchimoto
R
R
Miyazawa
T
T
Azuma
H
H
D000005:Abdomen / Q000473:pathology; D000818:Animals; D001202:Ascitic Fluid / Q000139:chemically induced / Q000473:pathology; D003287:Contrast Media / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D005260:Female; D006099:Granuloma / Q000139:chemically induced; D006207:Half-Life; D007047:Hysterosalpingography; D007274:Injections, Intraperitoneal; D007455:Iodine / Q000032:analysis; D007459:Iodized Oil / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics*; D007509:Irritants / Q000009:adverse effects; D011817:Rabbits; D011860:Radiography, Abdominal; D012449:Safety; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D003287:Contrast Media; D007509:Irritants; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007459:Iodized Oil; D007455:Iodine