Nucleotide excision repair and the link with transcription.
Nucleotide excision repair (NER) uses the products of about 30 genes to remove a damage-containing oligonucleotide from cellular DNA. The transcription factor TFIIH is an essential component of NER. In man, defects in NER can result in three distinct genetic disorders, whose features can be ascribed to abnormalities in DNA repair or transcription.
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.
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Lehmann
D003057:Cockayne Syndrome / Q000235:genetics; D004260:DNA Repair; D006197:Hair / Q000002:abnormalities*; D006801:Humans; D008957:Models, Genetic; D009711:Nucleotides; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000235:genetics; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic; D014983:Xeroderma Pigmentosum / Q000235:genetics
D009711:Nucleotides; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH