[Effect of olive oil and fish oil on parameters of lipids and antioxidants in hyperlipoproteinemia].
In 56 patients with HLP (40 with hypertriglyceridemia and mixed HLP respectively and 16 with hypercholesterolemia), changes in the lipid state and in the parameters of the antioxidative potential before and after a 4-week olive-oil phase, and after 8-, 20- and 32-week intakes of salmon-oil capsules were determined. The treatment with salmon-oil led to a decrease of triglycerides in patients with hypertriglyceridemia and mixed HLP respectively, on the other hand, it led to an increase of cholesterol in hypercholesterolemia. The increase of malondialdehyde as measure of lipid peroxidation in both patient groups underlines the necessity of a substitution of antioxidants. Further investigations are necessary before wide use of fish-oil capsules can be recommended, especially to avoid side-effects.
Abteilung Gerontologie/-Stoffwechsel, Universität Leipzig.
W
W
Reuter
B
B
Vorberg
K
K
Krumpolt
I
I
Sauer
D000328:Adult; D000368:Aged; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001053:Apolipoproteins / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D006951:Hyperlipoproteinemias / Q000097:blood*; D015228:Hypertriglyceridemia / Q000097:blood*; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology*; D012474:Salmon; D012643:Selenium / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D001053:Apolipoproteins; D002214:Capsules; D008076:Cholesterol, HDL; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D014810:Vitamin E; D008315:Malondialdehyde; D002784:Cholesterol; D005979:Glutathione Peroxidase; D012643:Selenium
Einfluss von Oliven- und Fischöl auf Fettstoffwechsel- und Antioxidantienparameter bei Hyperlipoproteinämie.