Metoclopramide blocks bromocriptine induced antihypertensive effect in hypertensive patients.
Two groups of patients with essential hypertension were studied at the Vargas Hospital of Caracas. The first group of 9 patients under placebo treatment for 1 week received a single 2.5 mg oral dose of bromocriptine. Cardiovascular and biochemical parameters including arterial pressure, heart rate, plasma renin activity, and plasma aldosterone levels were evaluated during the 6-hour period before and after the administration of drugs. The second experimental design was as follows: 9 patients received 30 mg metoclopramide daily (divided in 3 doses) for 1 week. At the end of the period a single oral dose of 2.5 mg of bromocriptine was given to each patient. The cardiovascular and biochemical parameters were also determined. Bromocriptine reduced both systolic and diastolic arterial pressure. The peak antihypertensive effect was shown 3 hours after administration of the drug, but the reduction of arterial pressure lasted approximately 6 hours. At the same time bromocriptine reduced plasma aldosterone levels and plasma renin activity. This reduction persisted 6 hours after its administration. Metoclopramide reversed the antihypertensive effect of bromocriptine and its effect on aldosterone secretion and plasma renin activity. We conclude from these findings that bromocriptine acts as an antihypertensive agent by stimulating DA2 dopaminergic receptor, the dopaminergic receptor involved in aldosterone and renin secretion is possibly DA2.
Luchsinger
A
A
Section of Clinical Pharmacology, Vargas Medical School, Central University of Venezuela, Caracas, Venezuela.
Grilli
M
M
Forte
P
P
Morales
E
E
Velasco
M
M
D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000037:antagonists & inhibitors*; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D012083:Renin / Q000097:blood
D000959:Antihypertensive Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D001971:Bromocriptine; D000450:Aldosterone; D012083:Renin; D008787:Metoclopramide