An improved 191Os/191mIr generator using a hybrid anion exchanger.
Iridium-191m is an attractive radionuclide for first-pass radionuclide angiography, but development of an 191Os/191mIr generator with high 191mIr yield has proven difficult. The use of trans-dioxobisoxalatoosmate(VI) as a parent species results in a higher initial yield (20 to 25%/mL), but the yield decreases over time. Using an anion-exchange column of tridodecylmethylammonium chloride-treated silica gel and AG MP-1 resin, we have developed an improved 191Os/191mIr generator with higher initial yield (25 to 30%/mL) and a slower rate of decrease than the previous design.
Packard
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Division of Nuclear Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Day
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PJ
Treves
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D007475:Ion Exchange Resins; D007495:Iridium / Q000737:chemistry*; D007554:Isotopes; D009992:Osmium / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds; D011854:Radiochemistry / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry*; D058428:Silica Gel; D012822:Silicon Dioxide
D007475:Ion Exchange Resins; D007554:Isotopes; D000644:Quaternary Ammonium Compounds; D011868:Radioisotopes; D009992:Osmium; D007495:Iridium; D058428:Silica Gel; C009543:tridodecylmethylammonium; D012822:Silicon Dioxide