Flavoprotein structure and mechanism. 8. Structure-function relations for old yellow enzyme.
The past 5 years have seen tremendous progress in our knowledge of old yellow enzyme (OYE) as a number of OYEs have been cloned and expressed, a high-resolution crystal structure has been determined for one of these, and new substrates have been found that can be turned over by the enzyme. Together these studies do not yet define the physiological role of OYE, but they lead to significant new insights into the enzymatic properties and structure-function relations of OYE.
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA.
P A
PA
Karplus
K M
KM
Fox
V
V
Massey
D000595:Amino Acid Sequence; D002384:Catalysis; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D005800:Genes, Fungal; D008024:Ligands; D008969:Molecular Sequence Data; D009249:NADP / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013329:Structure-Activity Relationship
D005656:Fungal Proteins; D008024:Ligands; D009249:NADP; D009252:NADPH Dehydrogenase