Breaking the shackles of the genetic code: engineering retroviral proteases through total chemical synthesis.
Kent
S B
SB
Scripps Research Institute, La Jolla, California 92037, USA.
Baca
M
M
Elder
J
J
Miller
M
M
Milton
R
R
Milton
S
S
Rao
J K
JK
Schnölzer
M
M
D000595:Amino Acid Sequence; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D002415:Cats; D005815:Genetic Code; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000201:enzymology* / Q000235:genetics; D046911:Macromolecular Substances; D008961:Models, Structural; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods*; D017433:Protein Structure, Secondary; D012190:Retroviridae / Q000201:enzymology*; D013379:Substrate Specificity
D046911:Macromolecular Substances; D010455:Peptides; D016282:Aspartic Acid Endopeptidases; C095555:FIV protease; D016333:HIV Protease