Tissue plasminogen activator in the surgical excision of subfoveal choroidal neovascular membranes.
We investigated the use of tissue plasminogen activator (t-PA) as an adjunct to the surgical removal of subfoveal choroidal neovascular membranes. t-PA in a concentration of 6 micrograms/0.1 cc dissolved the fibrin rim surrounding recent subfoveal membranes but was less effective on more mature lesions. t-PA may be a useful intraoperative tool to limit the damage to surrounding structures during the surgical excision of recent subfoveal choroidal neovascular membranes with surrounding fibrin rims.
Baylor College of Medicine, Houston, Texas 77030, USA.
J W
JW
Thomas
P F
PF
Lopez
H M
HM
Lambert
D000328:Adult; D000368:Aged; D002462:Cell Membrane; D017024:Chemotherapy, Adjuvant; D002829:Choroid / Q000098:blood supply*; D005260:Female; D005342:Fibrinolysis; D005584:Fovea Centralis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000601:surgery*; D010960:Plasminogen Activators / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014792:Visual Acuity
D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator