The effect of aortic coarctation on expression of endothelin-1 and endothelin receptors in heart and lungs.
Expression of prepro-endothelin-1 (ppET-1), and endothelin (ET) receptor subtype (ETA, ETB) mRNAs was studied in atria, ventricles, and lungs of aortic coarctated rats. During 8 weeks following aortic banding, rats developed ventricular hypertrophy. The levels of expression of ppET-1, ETA- and ETB-receptors were significantly lower in the ventricles of coarctated rats than in sham-operated animals. In atria, the level of expression of ppET-1, ETA and ETB-receptors was not significantly changed. These results indicate that production of ET-1 is decreased and ETA and ETB-receptors are down-regulated in hypertrophied ventricles 8 weeks after aortic coarctation. This may be a compensatory response to pressure overload.
Unit of Clinical Physiology, Minerva Foundation Institute for Medical Research, Helsinki, Finland.
M L
ML
Sirviö
N
N
Uhlenius
P
P
Stewen
K
K
Metsärinne
F
F
Fyhrquist
D000818:Animals; D001017:Aortic Coarctation / Q000235:genetics*; D001483:Base Sequence; D016232:Endothelins / Q000235:genetics*; D008168:Lung / Q000737:chemistry*; D008297:Male; D008969:Molecular Sequence Data; D009206:Myocardium / Q000737:chemistry*; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D017466:Receptors, Endothelin / Q000235:genetics*
D016232:Endothelins; D012333:RNA, Messenger; D017466:Receptors, Endothelin