Regulation of viral and cellular gene expression in sensory neurons.
Herpes simplex virus (HSV) establishes latent infections of neuronal cells but replicates readily in other cell types. This effect is dependent upon the presence of the inhibitory cellular transcription factor Oct-2 in neuronal cells. This factor inhibits the viral immediate-early gene promoters by at least two distinct mechanisms. The significance of Oct-2 in regulating viral and cellular gene expression in sensory neurons is discussed.
Latchman
D S
DS
Division of Molecular Pathology, University College London Medical School.
D000818:Animals; D001483:Base Sequence; D002461:Cell Line, Transformed; D006224:Cricetinae; D004279:DNA, Viral; D004268:DNA-Binding Proteins / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D015967:Gene Expression Regulation, Viral; D017781:Genes, Immediate-Early; D008969:Molecular Sequence Data; D009475:Neurons, Afferent / Q000378:metabolism* / Q000821:virology; D050813:Octamer Transcription Factor-2; D011401:Promoter Regions, Genetic; D051381:Rats; D018139:Simplexvirus / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D014779:Virus Replication
D004279:DNA, Viral; D004268:DNA-Binding Proteins; D050813:Octamer Transcription Factor-2; C489205:Pou2f2 protein, rat; D014157:Transcription Factors