Thyroid function parameters during a selenium repletion/depletion study in phenylketonuric subjects.
Phenylketonuric (PKU) subjects have a limited supply of selenium (Se) in their phenylalanine-restricted diet. A Se repletion (1 microgram Se/kg/day)/depletion study was conducted in PKU children to determine the effect of Se on thyroid function parameters. The initial plasma Se concentration (mean +/- SD: 0.26 +/- 0.12 mumol/L, p < 0.00003, n = 10) and glutathione peroxidase (GSH-Px) activity (140 +/- 58 U/L, p < 0.00003, n = 10) were significantly lower compared to age-matched controls. After 14 weeks of supplementation, the plasma Se concentration (mean +/- SD: 0.74 +/- 0.20 mumol/L) normalized (normal range: 0.57-1.15 mumol/L, mean +/- SD: 0.76 +/- 0.13 mumol/L, n = 32) and remained stable thereafter during repletion. Plasma GSH-Px activity reached normal values after 18 weeks of supplementation (312 +/- 57 U/L; normal range: 238-492 U/L, mean +/- SD: 345 +/- 54 U/L, n = 32) and increased significantly for up to eight weeks thereafter (332 +/- 52 U/L). Individual and mean thyroid parameters were initially normal in all cases. The mean concentrations of plasma thyroxine (T4: p < 0.025), free T4 (FT4: p < 0.01) and reverse triiodothyronine (rT3: p < 0.005) decreased to 75% of their initial value within three weeks of Se supplementation and remained stable thereafter, within a normal physiological range during selenium supplementation. They increased back to their initial values three weeks (T4: p < 0.05, FT4: p < 0.05) and six weeks (rT3: p < 0.025) respectively, after the end of the supplementation. In conclusion, Se supplementation modifies thyroid function parameters in Se-deficient PKU subjects most likely by an increase in activity of type I 5'-deiodinase (5'-DIase I).
School of Medicine and Pharmaceutical Sciences, Antwerp-Wilrijk, Belgium.
M R
MR
Calomme
J B
JB
Vanderpas
B
B
François
M
M
Van Caillie-Bertrand
A
A
Herchuelz
N
N
Vanovervelt
C
C
Van Hoorebeke
D A
DA
Vanden Berghe
D000293:Adolescent; D002648:Child; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007453:Iodide Peroxidase / Q000097:blood; D008297:Male; D010661:Phenylketonurias / Q000503:physiopathology*; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood; D013961:Thyroid Gland / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones; D007453:Iodide Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium