Oral prednisone as a risk factor for infections in children with asthma.
OBJECTIVE
To determine whether the frequency of acute infections in children with asthma is associated with the number of doses of prednisone received for asthma attacks.


METHODS
A cohort study.


METHODS
Primary care clinic and emergency department of an inner-city teaching hospital from March 31, 1992, to May 31, 1993.


METHODS
Convenience sample of clinic enrollees aged 2 to 14 years who had made two or more outpatient visits for acute asthma in the preceding year. Eighty-six children were enrolled. Seventy-eight (91%) completed the study.


METHODS
The independent variable was cumulative prednisone dose received during the study period. Outcome variables were episodes of acute infections.


RESULTS
The mean (+/-SD) number of doses of prednisone (2 mg/kg to a maximum of 60 mg) received was 9.5 +/- 11.8 doses (range, 0 to 57 doses). Ninety-four episodes of acute infection occurred in 50 children. No difference was observed in the mean number of doses of prednisone received by those with the infection compared with those without the infection. No correlation was observed between the number of doses of prednisone received and the number of episodes of each infection.


CONCLUSIONS
The administration of prednisone as short courses for acute asthma is not associated with an increase in the number of episodes of common acute infections.
Division of General Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
C C
CC
Grant
A K
AK
Duggan
M
M
Santosham
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C
DeAngelis
D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007239:Infections / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D011241:Prednisone / Q000009:adverse effects*; D012307:Risk Factors
D000893:Anti-Inflammatory Agents; D011241:Prednisone