Hepatic lymph nodes as follow-up factor in primary biliary cirrhosis. An ultrasound study.
BACKGROUND
The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC).


METHODS
Twenty-three consecutive patients were examined with repeated liver biopsies, laboratory tests, and ultrasonographic examinations of the hepatoduodenal ligament. The effect of treatment with ursodeoxycholic acid (UDCA) on these factors was also studied.


RESULTS
A correlation was found between changes in lymph node size and changes in markers of hepatocellular damage, cholestasis, and humoral immunoreactivity and also with intralobular inflammation. In the UDCA-treated patients the node size decreased slightly during 2 years of treatment, whereas it was unchanged in the control group (p = 0.0528).


CONCLUSIONS
Changes in the size of the lymph nodes in the hepatoduodenal ligament may reflect inflammation and cholestasis in PBC and thus be a valuable indicator in the follow-up of patients with this disease.
Dept. of Diagnostic Radiology, University Hospital, Lund, Sweden.
K
K
Lyttkens
H
H
Prytz
L
L
Forsberg
I
I
Hägerstrand
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D014580:Ursodeoxycholic Acid