Electrotonic coupling between two CA3 hippocampal pyramidal neurons: a distributed cable model with somatic gap-junction.
A model of a pair of electrotonically coupled CA3 hippocampal pyramidal neurons is presented. Each neuron is represented by a tapered equivalent cable attached to an isopotential soma. The synaptic potential in a neuron soma is determined as a consequence of electrical coupling to another soma that receives a synaptic input on its dendritic tree. Estimates of the coupling resistances, soma input resistances and soma-to-dendritic tree conductance ratio show that a substantial current may arise in a neuron as a consequence of synaptic activity in a neuron coupled to it. The small increase in decay time due to coupling in the model indicates that actual coupling is between more than just pairs of neurons.
Poznanski
R R
RR
The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW, Australia.
Gibson
W G
WG
Bennett
M R
MR
D000818:Animals; D002450:Cell Communication; D017629:Gap Junctions / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D008322:Mammals; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology