Dystrophic form of inherited epidermolysis bullosa in a dog (Akita Inu).
We report a dog with dystrophic epidermolysis bullosa. This 4-year-old female Akita Inu, a species of Canis familiaris var. japonicus Temminck, had a 3-year-history of ulcers and scars over the pressure areas on the limbs, and dystrophic nails, since the age of 1 year, which corresponds to early adulthood in humans. Electron microscopy of a blister revealed separation beneath the lamina densa, and a reduction in the number of anchoring fibrils. The NC-1 domain of type VII collagen was positively stained with monoclonal antibody LH7.2 at the basement membrane zone. These findings indicate that humans and dogs have a similar response to antibody LH7.2, which may aid the development of an animal model for this disease.
Nagata
M
M
Department of Clinical Pathology, Nippon Veterinary and Animal Science University, School of Veterinary Medicine, Tokyo, Japan.
Shimizu
H
H
Masunaga
T
T
Nishikawa
T
T
Nanko
H
H
Kariya
K
K
Washizu
T
T
Ishida
T
T
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D003094:Collagen / Q000032:analysis; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D016108:Epidermolysis Bullosa Dystrophica / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D011312:Pressure / Q000009:adverse effects*; D012867:Skin / Q000378:metabolism / Q000648:ultrastructure
D003094:Collagen