Renal transplantation one week after conception.
A successful 38-week pregnancy is reported following renal transplantation approximately 1 week after conception. The patient was treated with quadruple sequential induction therapy, maintenance immunosuppression, and routine posttransplantation care, including ganciclovir treatment for a symptomatic cytomegalovirus infection during the pregnancy and 3 months after delivery. No decline in renal function was noted. The mother and child remain healthy at 18 months. This case demonstrates the ability of renal transplant patients to maintain renal function throughout pregnancy and the lack of deleterious effects upon the child during gestation and at up to 18 months after birth, despite significant immunosuppression, including antithymocyte globulin induction therapy, and infectious complications of the mother's renal transplantation.
Miller
B W
BW
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Howard
T K
TK
Goss
J A
JA
Mostello
D J
DJ
Holcomb
W L
WL
Brennan
D C
DC
D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000601:surgery; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications