Apolipoprotein A-I-containing lipoproteins and atherosclerosis.
Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholesterol transport. This review describes the different apolipoprotein A-I-containing HDL subfractions, their role in reverse cholesterol transport, and their metabolic interconversions and relationship with lipoprotein-modifying enzymes.
Unité-325 Institut National de la Santé Et de la Recherche Médicale, Institut Pasteur de Lille, France.
A
A
Leroy
J
J
Dallongeville
J C
JC
Fruchart
D000818:Animals; D016632:Apolipoprotein A-I / Q000737:chemistry / Q000378:metabolism*; D001161:Arteriosclerosis / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D053480:Cholesterol Ester Transfer Proteins; D004195:Disease Models, Animal; D006023:Glycoproteins; D008049:Lipase / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism
D016632:Apolipoprotein A-I; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008049:Lipase