Energy metabolism during CAPD: a controlled study.
Abnormalities of energy metabolism may exacerbate the high prevalence of protein-calorie malnutrition and inadequate calorie intake in continuous ambulatory peritoneal dialysis (CAPD) patients, leading to further nutritional depletion. In a controlled study, using indirect calorimetry, we evaluated oxygen consumption (VO2), CO2 production, resting energy expenditure, and respiratory exchange ratio (RER) in 12 CAPD patients at rest and during a standard CAPD exchange and in 11 healthy nonuremic control patients. In addition, we investigated the influence of nutritional status and dialysis adequacy on energy metabolism in the CAPD group. There was no significant difference in resting energy parameters between the two groups. Unlike the control group, blood glucose and RER were maintained during prolonged fasting in the CAPD patients. This observation indicates that all the absorbed glucose was used as a metabolic fuel preventing fat oxidation. There was no significant relationship between energy expenditure and dialysis adequacy. There was no significant relationship between nutritional state (including energy intake) and energy expenditure despite evidence of malnutrition in 41% of the patients. If maintenance of "normal levels" of energy expenditure occurs in dialysis patients with suboptimal calorie intake (especially with evidence of protein-calorie malnutrition), this inability to conserve energy may act as an additional risk factor for ongoing malnutrition.
Harty
J
J
Department of Nephrology, Withington Hospital, Manchester, United Kingdom.
Conway
L
L
Keegan
M
M
Curwell
J
J
Venning
M
M
Campbell
I
I
Gokal
R
R
D000368:Aged; D000886:Anthropometry; D001481:Basal Metabolism; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D002153:Calorimetry, Indirect; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010101:Oxygen Consumption; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012119:Respiration
D001786:Blood Glucose