Adeno-associated virus (AAV) as a vector for gene transfer into glial cells of the human central nervous system.
To examine the potential of AAV as a vector for gene transfer in glial cells, an established astrocytoma cell line and short-term cultures derived from human oligodendroglioma have been coinfected with AAV and helper adenovirus. The level of AAV replication in glioma cells was high indicating that they express receptors for AAV.
Tenenbaum
L
L
Laboratory of Pharmacology, Free University of Brussels, Belgium.
Darling
J L
JL
Hooghe-Peters
E
E
D001254:Astrocytoma / Q000628:therapy / Q000821:virology*; D001932:Brain Neoplasms / Q000628:therapy / Q000821:virology*; D000229:Dependovirus / Q000235:genetics* / Q000502:physiology; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D009837:Oligodendroglioma / Q000628:therapy / Q000821:virology; D014407:Tumor Cells, Cultured; D014779:Virus Replication