Myelin mutants: new models and new observations.
The myelin mutants have been extensively used as tools to study the complex process of myelination in the central and peripheral nervous system. A multidisciplinary approach to the study of these models ultimately allows a correlation to be made between phenotype and genotype. This correlation may then lead to the formation of new hypotheses about the functions of the products of genes involved in myelination. This review presents a number of new myelin mutants which have recently been described. The species involved include mouse, rat, rabbit, hamster, and dog models. The genetic defect has not been elucidated in all of these animals, but most have been characterized clinically and pathologically, and, in some cases, biochemically. In addition, a better known myelin mutant, the trembler mouse, is discussed. Recent molecular findings have brought this fascinating mutant to the forefront of the field of peripheral nervous system research. The range of abnormalities in the mutants described in this review includes defects in specific myelin proteins, suspected abnormalities in membrane formation, and apparent defects of the oligodendrocyte cytoskeleton. These findings underscore the complexity of the myelination process and highlight the numerous ways in which it can be disrupted.
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706, USA.
K F
KF
Lunn
M L
ML
Fanarraga
I D
ID
Duncan
D000818:Animals; D006224:Cricetinae; D004285:Dogs; D008647:Mesocricetus; D051379:Mice; D009154:Mutation; D004676:Myelin Basic Protein / Q000032:analysis; D018991:Myelin Proteolipid Protein / Q000032:analysis / Q000235:genetics; D009186:Myelin Sheath / Q000737:chemistry / Q000473:pathology* / Q000502:physiology; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D004676:Myelin Basic Protein; D018991:Myelin Proteolipid Protein