Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.
Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
J
J
Galli
L S
LS
Li
A
A
Glaser
C G
CG
Ostenson
H
H
Jiao
H
H
Fakhrai-Rad
H J
HJ
Jacob
E S
ES
Lander
H
H
Luthman
D000818:Animals; D001483:Base Sequence; D001835:Body Weight; D002874:Chromosome Mapping; D017931:DNA Primers / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004195:Disease Models, Animal; D005215:Fasting; D005260:Female; D008040:Genetic Linkage; D005947:Glucose / Q000378:metabolism; D006943:Hyperglycemia / Q000235:genetics; D007328:Insulin / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D011916:Rats, Inbred F344; D011922:Rats, Mutant Strains / Q000235:genetics*
D017931:DNA Primers; D007328:Insulin; D005947:Glucose