[Anesthesia in a patient with history of multiple drug allergies].
A 38-year-old woman was admitted for intranasal ethmoidectomy. She had a history of serious anaphylactic reactions, including respiratory distress, hypotension and unconsciousness, to nonsteroidal anti-inflammatory drugs (Loxonin, Niflan) and antibiotics (Kefral, Minomycin). Preoperative intradermal skin tests against anesthesia-related drugs showed positive reactions to succinylcholine and vecuronium. After bilateral maxillary nerve block with 0.5 % bupivacaine (negative intradermal test) 3 ml, anesthesia was induced with diazepam, nitrous oxide, oxygen and sevoflurane. Trachea was intubated smoothly without muscle relaxants. Anesthesia was maintained with nitrous oxide, oxygen and sevoflurane 0.5-1 %. The anesthesia and postoperative course of this patient were uneventful. To confirm the initiation of allergic reaction to anesthetics used in the patient, serum histamine, tryptase, and complement 1, 3 and 4 factors were measured at 3 points: preoperatively, immediately after the induction, and after extubation. They showed normal levels. These results showed that no allergic reaction occurred perioperatively. In conclusion, the valuable information was provided for the choice of anesthetics by thorough evaluation of the past history and intradermal testing.
Department of Anesthesiology, Nihon University School of Medicine, Tokyo.
Y
Y
Horiguchi
H
H
Mitsuhata
S
S
Ikeno
H
H
Fukuda
S
S
Inoue
J
J
Saitoh
Y
Y
Hirabayashi
R
R
Shimizu
D000328:Adult; D000707:Anaphylaxis / Q000517:prevention & control*; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D002045:Bupivacaine; D004342:Drug Hypersensitivity / Q000150:complications; D004987:Ethers; D015521:Ethmoid Sinusitis / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D007428:Intradermal Tests; D008738:Methyl Ethers; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D002045:Bupivacaine