Characterization of the human XPA promoter.
We cloned the human xeroderma pigmentosum group A gene (XPA) and characterized the XPA promoter (pXPA) by transient cat expression. The pXPA is extraordinarily weak in human fibroblasts (1% of RSV-LTR) and appears to function without any of the usual promoter elements. Regions containing positive and negative control elements were localized.
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.
R S
RS
Topping
S P
SP
Myrand
B L
BL
Williams
J C
JC
Albert
J C
JC
States
D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D014983:Xeroderma Pigmentosum / Q000235:genetics*; D051760:Xeroderma Pigmentosum Group A Protein
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D051760:Xeroderma Pigmentosum Group A Protein