Transcriptional regulation of the human intercellular adhesion molecule-1 gene: a short overview.
Human intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein that functions as a ligand for lymphocyte function-associated antigen-1, plays an important role in mediating cell-cell interactions in inflammatory reactions. It is induced by proinflammatory cytokines such as interleukin-1, tumor necrosis factor-alpha or interferon-gamma, as well as by phorbol esters, retinoic acid and lipopolysaccharide. Furthermore, ICAM-1 is upregulated by interleukin-6, which suggests that it belongs to the family of acute phase response genes. Investigation of the 5'-regulatory region of the human ICAM-1 gene revealed sequence motifs for a variety of transcription factors implicated in transcriptional regulation. This review summarizes the current knowledge of the transcriptional regulation of the human ICAM-1 gene.
Ernst Boehringer Institut, Bender & Co, Vienna, Austria.
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Audette
D001483:Base Sequence; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008969:Molecular Sequence Data; D014158:Transcription, Genetic / Q000276:immunology*
D018799:Intercellular Adhesion Molecule-1