Chronic alcoholic myopathy: diagnostic clues and relationship with other ethanol-related diseases.
We report the clinical, laboratory, functional and histological features of 100 male alcoholic patients of whom 44 had chronic alcoholic myopathy (CAM). We evaluated the use of non-invasive tests in detecting CAM, and examined its relationship with other ethanol-related diseases such as cirrhosis and cardiomyopathy. Of the CAM patients, 24 (55%) presented clinical symptoms of myopathy, whereas proximal muscle atrophy was observed in 15 patients (35%). Thirty-seven (80%) had significantly decreased muscle strength by myometric measurement and 27 (60%) had abnormally increased serum muscle enzymes. In most of these patients, the myopathy was classified as mild. The most frequent histological findings were myocytolysis, fibre size variability and type II fibre atrophy. As there was a good correlation between clinical symptoms, decreased muscle strength on myometry and histological evidence of CAM, muscle biopsy may be avoidable in some of these patients. Cardiomyopathy and liver cirrhosis were more frequent in patients with CAM, and should be checked for in chronic alcoholics with skeletal myopathy.
Department of Internal Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
E
E
Sacanella
J
J
Fernández-Solà
M
M
Cofan
J M
JM
Nicolás
R
R
Estruch
E
E
Antúnez
A
A
Urbano-Márquez
D000328:Adult; D000437:Alcoholism / Q000150:complications*; D002310:Cardiomyopathy, Alcoholic / Q000209:etiology; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D009752:Nutritional Status; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity