Drug effects on intraocular pressure and vascular flow in the bovine perfused eye using radiolabelled microspheres.
A novel technique is described in which the effect of the beta-adrenoceptor antagonists timolol and carteolol, and the vasodilators sodium nitroprusside (SNP) and verapamil on intraocular pressure (IOP) and the distribution of ocular flow in the bovine arterially perfused eye is investigated using radiolabelled microspheres. At maximum IOP-reducing dose timolol was found to significantly reduce perfusion in the choroid and, at higher dose, it was found to significantly reduce perfusion in the iris. By contrast, a maximal IOP-reducing dose of carteolol markedly reduced perfusion in the iris, ciliary body and choroid. Vasoconstriction induced by carteolol was not inhibited by the alpha-antagonist phentolamine. Against a background of vascular tone induced by noradrenaline, SNP and verapamil were found to significantly increase perfusion in the iris, ciliary body and choroid. The effects of these drugs upon the vasculature of the bovine perfused eye are varied and complex and may not bear a direct relationship to their ocular hypotensive effect.
Department of Pharmacology, University of Glasgow, Scotland.
J C
JC
Millar
W S
WS
Wilson
R D
RD
Carr
R G
RG
Humphries
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002354:Carteolol / Q000494:pharmacology; D002417:Cattle; D002565:Cerium Radioisotopes; D002829:Choroid / Q000098:blood supply; D002924:Ciliary Body / Q000098:blood supply; D005123:Eye / Q000098:blood supply*; D007429:Intraocular Pressure / Q000187:drug effects*; D007498:Iris / Q000098:blood supply; D008863:Microspheres; D009599:Nitroprusside / Q000494:pharmacology; D010477:Perfusion; D012039:Regional Blood Flow / Q000187:drug effects; D013999:Timolol / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D002565:Cerium Radioisotopes; D014665:Vasodilator Agents; D009599:Nitroprusside; D013999:Timolol; D002354:Carteolol; D014700:Verapamil