Dystrophic form of inherited epidermolysis bullosa in a dog (Akita Inu).
We report a dog with dystrophic epidermolysis bullosa. This 4-year-old female Akita Inu, a species of Canis familiaris var. japonicus Temminck, had a 3-year-history of ulcers and scars over the pressure areas on the limbs, and dystrophic nails, since the age of 1 year, which corresponds to early adulthood in humans. Electron microscopy of a blister revealed separation beneath the lamina densa, and a reduction in the number of anchoring fibrils. The NC-1 domain of type VII collagen was positively stained with monoclonal antibody LH7.2 at the basement membrane zone. These findings indicate that humans and dogs have a similar response to antibody LH7.2, which may aid the development of an animal model for this disease.
Department of Clinical Pathology, Nippon Veterinary and Animal Science University, School of Veterinary Medicine, Tokyo, Japan.
M
M
Nagata
H
H
Shimizu
T
T
Masunaga
T
T
Nishikawa
H
H
Nanko
K
K
Kariya
T
T
Washizu
T
T
Ishida
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D003094:Collagen / Q000032:analysis; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D016108:Epidermolysis Bullosa Dystrophica / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D011312:Pressure / Q000009:adverse effects*; D012867:Skin / Q000378:metabolism / Q000648:ultrastructure
D003094:Collagen