Design and synthesis of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic.
Kiso
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Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D016333:HIV Protease / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010649:Phenylalanine; D010654:Phenylbutyrates; D011392:Proline; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D010654:Phenylbutyrates; D010649:Phenylalanine; C034940:3-amino-2-hydroxy-4-phenylbutanoic acid; D011392:Proline; D016333:HIV Protease