Activity of sparfloxacin on Staphylococcus epidermidis attached to plastic catheters.
The activity of sparfloxacin on Staphylococcus epidermidis biofilms on different plastic catheters was evaluated. Sparfloxacin showed high bactericidal activity against S. epidermidis biofilms on Vialon and polyvinylchloride catheters. The combination of sparfloxacin with amikacin or rifampicin significantly increased its activity against bacterial biofilms on polyurethane and Teflon catheters.
Department of Microbiology, School of Medicine, Sevilla, Spain.
A
A
Pascual
I
I
García
E
E
Ramirez de Arellano
E J
EJ
Perea
D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D001672:Biocompatible Materials; D018441:Biofilms / Q000187:drug effects; D002404:Catheterization / Q000295:instrumentation; D004359:Drug Therapy, Combination / Q000494:pharmacology; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D010969:Plastics; D011138:Polytetrafluoroethylene; D011140:Polyurethanes; D015363:Quinolones / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D001672:Biocompatible Materials; D024841:Fluoroquinolones; D010969:Plastics; D011140:Polyurethanes; D015363:Quinolones; D000583:Amikacin; D011138:Polytetrafluoroethylene; C061363:sparfloxacin; D012293:Rifampin