Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments.
Antihypertensive treatments were given to young and adult SHRs, to prevent and reverse hypertension, respectively. Cardiac hypertrophy and the steady state level of the "fetal" genes, ANP, alpha-skeletal actin (alpha-skA), and beta myosin heavy chain (beta-MHC) mRNAs were assessed. Our findings show that the reduction of blood pressure does not consistently result in a similar regression of the "fetal gene program".
Basil and Gerald Felsenstein Medical Research Center, Petah-Tikva, Israel.
G
G
Kessler-Icekson
Y
Y
Barhum
H
H
Schlesinger
J
J
Shohat
H
H
Sharma
W
W
Schaper
D000199:Actins / Q000235:genetics; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D009320:Atrial Natriuretic Factor / Q000235:genetics; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000235:genetics* / Q000503:physiopathology; D015870:Gene Expression / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D009218:Myosins / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR
D000199:Actins; D000959:Antihypertensive Agents; D009320:Atrial Natriuretic Factor; D009218:Myosins