A rabbit tooth-pulp assay to quantify efficacy and duration of antinociception by local anesthetics infiltrated into maxillary tissues.
The rabbit tooth-pulp assay is well established as a method for measuring the efficacy and potency of parenteral analgesic drugs. We describe a method for administration of local anesthetic drugs into the maxillary arch and subsequent measurements of antinociceptive action. It was possible to use two different methods of ED50 estimation and to provide measures of the potency, efficacy, and duration of local anesthetic drugs. These measurements corresponded with in vitro estimates of potency and duration and with intrinsic observations of the clinical actions.
Thut
P D
PD
Department of Pharmacology and Therapeutics, Baltimore College of Dental Surgery, Dental School, University of Maryland 21201-1586, USA.
Turner
M D
MD
Cordes
C T
CT
Wynn
R L
RL
D000698:Analgesia; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003782:Dental Pulp / Q000187:drug effects*; D003791:Dental Pulp Test; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008437:Maxilla / Q000187:drug effects* / Q000378:metabolism; D008619:Mepivacaine / Q000494:pharmacology / Q000627:therapeutic use; D011343:Procaine / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits
D000779:Anesthetics, Local; D011343:Procaine; D008012:Lidocaine; D008619:Mepivacaine