Vaginal rhabdomyosarcoma in a patient with Noonan syndrome.
This is the first report of a Noonan syndrome patient who has had a vaginal rhabdomyosarcoma. Recent reports of Noonan syndrome patients with leukaemia have prompted speculation that there may be a slightly increased malignancy risk associated with this syndrome.
Khan
S
S
Department of Oncology, Alder Hey Children's Hospital, Liverpool, UK.
McDowell
H
H
Upadhyaya
M
M
Fryer
A
A
D004252:DNA Mutational Analysis; D005145:Face / Q000002:abnormalities; D005260:Female; D006801:Humans; D007223:Infant; D009634:Noonan Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D012307:Risk Factors; D014625:Vaginal Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology