Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk.
Feeding of bovine milk to mice induced a high incidence of bacterial translocation from the intestines to the mesenteric lymph nodes, and the bacteria involved were mainly members of the family Enterobacteriaceae. Supplementation of the milk diet with bovine lactoferrin or a pepsin-generated hydrolysate of bovine lactoferrin resulted in significant suppression of bacterial translocation. Our findings suggest that this ability of lactoferrin to inhibit bacterial translocation may be due to its suppression of bacterial overgrowth in the guts of milk-fed mice.
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa, Japan.
S
S
Teraguchi
K
K
Shin
T
T
Ogata
M
M
Kingaku
A
A
Kaino
H
H
Miyauchi
Y
Y
Fukuwatari
S
S
Shimamura
D000284:Administration, Oral; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D004032:Diet; D004755:Enterobacteriaceae / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D007422:Intestines / Q000033:anatomy & histology / Q000187:drug effects* / Q000382:microbiology*; D007781:Lactoferrin / Q000008:administration & dosage / Q000494:pharmacology*; D008198:Lymph Nodes / Q000382:microbiology; D008643:Mesentery / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008892:Milk
D007781:Lactoferrin