[Isotypes and subtypes of anti-SS-A and/or SS-B antibodies in different subgroups of Sjögren's syndrome].
Profiles of anti-SS-A/SS-B antibodies, including their isotypes and subtypes, in patients with primary Sjögren's syndrome (SS) were similar to those in SS patients with systemic lupus erythematosus (SLE), except for anti-SS-A52-Kd/60-Kd antibody profiles. The incidence and titers of these antibodies in SS patients with rheumatoid arthritis, however, were lower than those in primary SS or SS patients with SLE. It is suggested that IgA anti-SS-A/SS-B antibodies are produced in the salivary gland. In addition, IgG1 anti-SS-A antibodies were dominant in all groups of SS patients examined. The results indicate a preferential activation of Th2 helper T cells in SS.
Department of Internal Medicine, Tokai University School of Medicine.
M
M
Takaya
Y
Y
Ichikawa
D000974:Antibodies, Antinuclear / Q000145:classification* / Q000378:metabolism; D006801:Humans; D012469:Salivary Glands / Q000276:immunology; D012859:Sjogren's Syndrome / Q000145:classification* / Q000276:immunology
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies