The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype.
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544-1014, USA.
A J
AJ
Levine
M C
MC
Wu
A
A
Chang
A
A
Silver
E F
EF
Attiyeh
J
J
Lin
C B
CB
Epstein
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003062:Codon / Q000235:genetics; D005260:Female; D016368:Frameshift Mutation; D016158:Genes, p53; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D016296:Mutagenesis; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D009928:Organ Specificity; D010641:Phenotype; D017354:Point Mutation; D017386:Sequence Homology, Amino Acid; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D014981:Xenopus
D003062:Codon; D016159:Tumor Suppressor Protein p53