[Changes of the plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cerebral infarction induced by the venous occlusion].
To examine the fibrinolytic system and platelet factors (PF4 and beta-TG), we conducted a venous occlusion test (V.O. test) on two groups of elderly patients suffering from cerebral infarction, one group being able to walk (A group), the other being bed-ridden for during a long period (B group). Their levels of t-PA, PAI-1 antigen and platelet factors were compared between A or B, A + B and healthy elderly groups. The t-PA antigen level of both group A and B after the V.O. test tended to increase. The t-PA values of A + B groups after the V.O. test were also similar to that of the healthy elderly. The PAI-1 antigen level of both group A and B before the V.O. test was higher than that of the healthy elderly. However, the PAI-1 antigen level of both group A and B tended to decrease after the V.O. test. No remarkable changes were noted in PF4 and beta-TG, which have been thought to reflect platelet function. The above findings suggest that the fibrinolytic activity in A or B groups can recover through stimulation by exercise training and some medical treatment.
Second Department of Internal Medicine, Aichi Medical University.
S
S
Wakamatsu
T
T
Banno
M
M
Tohnai
T
T
Oguri
D001780:Blood Coagulation Tests / Q000379:methods*; D002544:Cerebral Infarction / Q000097:blood* / Q000503:physiopathology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000503:physiopathology; D005342:Fibrinolysis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010978:Platelet Factor 4 / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000097:blood*; D001620:beta-Thromboglobulin / Q000032:analysis
D017395:Plasminogen Activator Inhibitor 1; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D010959:Tissue Plasminogen Activator