Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.
We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.
Nagoya University Graduate School of Agriculture, Japan.
Y
Y
Nakagawa
H
H
Asai
J
J
Kitoh
H
H
Mori
K
K
Nakano
D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D049308:Dioxygenases; D004827:Epilepsy / Q000201:enzymology* / Q000235:genetics; D020022:Genetic Predisposition to Disease; D051379:Mice; D008969:Molecular Sequence Data; D010105:Oxygenases / Q000235:genetics*; D017378:Quinolinic Acid / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
D012333:RNA, Messenger; D010105:Oxygenases; D049308:Dioxygenases; D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D017378:Quinolinic Acid