[Exercise capacity after heart transplantation].
Independently of phenomena related to rejection, atherosclerosis of the grafted heart or high blood pressure, there exists a qualitative and quantitative degradation of response to exercise in heart transplant recipients. Maximal oxygen consumption is generally reduced to 40 to 60% of normal levels. There are several interactive mechanisms. Paradoxically, the transplanted heart is a clear demonstration of the fact that several other elements are involved in the organisms response to exercise. Indeed, ventilation, exercise load, peripheral circulation, muscle metabolism and neurohormonal response also play a role. Vasoactivity of the peripheral arteries limits distribution and extraction of oxygen during exercise. Noradrenaline, renin, atrial natriuretic factor, vasopressin and endothelin levels are normal at rest, but an overreaction occurs during exercise. The percentage of type I (oxidative) fibres is reduced in muscles. Cyclosporine has also been shown to have a toxic effect on mitochondria in muscles. The deinnervated transplanted heart is thus called upon to work in coordination with peripheral elements which have also undergone alterations. Consequently, response to exercise cannot be significantly increased above the level reached before transplantation. Usually patients are not greatly hindered in their daily activities and rarely complain of breathlessness. Nevertheless, an improvement would be appreciated. A coherent physical rehabilitation programme can increase maximal oxygen consumption by 25 to 30% in these patients, essentially via improvement in peripheral anomalies. It is more difficult to modify cardiac response.
Cohen-Solal
A
A
Service de Cardiologie, Hôpital Beaujon, Clichy.
Pansard
Y
Y
Gourgon
R
R
D015444:Exercise / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D016491:Peripheral Vascular Diseases / Q000209:etiology; D011184:Postoperative Period; D013318:Stroke Volume / Q000502:physiology
Capacité fonctionnelle à l'effort après transplantation cardiaque.