Effect of thyroxine on experimental bronchospasm in guinea pigs.
Effect of Thyroxine was studied in histamine induced bronchospasm in guinea pigs. Chronic treatment with the drug significantly protected against experimental bronchospasm. Thyroxine also potentiated salbutamol evoked bronchodilation in this experimental model. Up-regulation of beta-2 adrenoceptors in bronchial smooth muscle may be the probable mechanism of action of thyroxine.
Department of Pharmacology, Burdwan Medical College.
D N
DN
Das
D
D
Bagchi
S
S
Mandal
K
K
De
S B
SB
Chaudhuri
S
S
Dutta
K
K
Roy
G
G
Roy
S
S
Saha
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D013974:Thyroxine / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D006632:Histamine; D013974:Thyroxine; D000420:Albuterol