Effect of short-term therapy with ceftizoxime and ceftriaxone on human peripheral WBC, serum immunoglobulins and lymphocyte subpopulations.
Serum immunoglobulins, peripheral white blood cells and lymphocyte subpopulation counts of twenty patients who received ceftizoxime and ceftriaxone for antimicrobial prophilaxis in surgery were examined in order to obtain a profile of the effects of these drugs on humoral and cellular immune system of human. No differences in the serum concentrations of IgG, IgM, IgA, peripheral blood lymphocytes and lymphocyte subpopulations 24 h and 48 h following the last dose of these two drugs were observed.
Karakaya
A
A
Department of Toxicology, Faculty of Pharmacy, Ankara University, Turkey.
Gümüşay
S
S
Yücesoy
B
B
Hengirmen
S
S
D000328:Adult; D015296:Ceftizoxime / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects*; D016131:Lymphocyte Subsets / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D007136:Immunoglobulins; D002443:Ceftriaxone; D015296:Ceftizoxime