Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine?
Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.
Tendler
M
M
Departamento de Helmintologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
Vilar
M M
MM
Brito
C A
CA
Freire
N M
NM
Katz
N
N
Simpson
A
A
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology; D005210:Fasciola hepatica / Q000276:immunology*; D005211:Fascioliasis / Q000517:prevention & control*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000276:immunology; D006801:Humans; D051379:Mice; D018996:Myelin P2 Protein / Q000276:immunology; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011817:Rabbits; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D025521:Tumor Suppressor Proteins; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*
D000947:Antigens, Helminth; D002352:Carrier Proteins; C107608:FABP7 protein, human; C082667:Fabp5 protein, mouse; C086936:Fabp7 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D025521:Tumor Suppressor Proteins; D014614:Vaccines, Synthetic