Accumulation of chromosomal changes in human glioma progression. A cytogenetic study of 50 cases.
Cytogenetic studies of 50 human gliomas, including three oligodendrogliomas, 16 grade I-III astrocytomas, and 31 glioblastomas multiforme, were performed using the short-term tissue culture method. The most common numerical chromosome aberrations were +7, -9, -10, -14, and loss of a sex chromosome. Structural changes involved predominantly the following chromosome arms: 1q, 2q, 6q, 7q, 9p, 14q, 17p, and 18p. Losses of chromosomes 9, 10, and 14, often occurring simultaneously and in polyploid clones, were observed almost exclusively in high-grade gliomas, and appear to constitute important events during glioma progression.
Laboratory of Electron Microscopy, Medical Academy of Gdańsk, Poland.
M
M
Debiec-Rychter
J
J
Alwasiak
P P
PP
Liberski
B
B
Nedoszytko
M
M
Babińska
K
K
Mrózek
B
B
Imieliński
J
J
Borowska-Lehman
J
J
Limon
D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D005909:Glioblastoma / Q000235:genetics; D005910:Glioma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000235:genetics; D014407:Tumor Cells, Cultured