[Excretion of fluoroquinolones into saliva].
The excretion of three fluoroquinolones derivatives into the saliva were studied in animal experiments. Ofloxacin per os administered to rabbits was excreted into the saliva well, and maintained the therapeutic level long--about 7 hours. Pefloxacin and ciprofloxacin iv. administered to mice were similarly excreted into the saliva at therapeutic levels and retained the antibacterial level for about 4 hours.
Debreceni Orvostudományi Egyetem, Stomatologiai Klinika, Gyógyszertani Intézet, Debrecen.
B A
BA
Kelentey
B J
BJ
Kelentey
I
I
Fekete
J
J
Kozma
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D051379:Mice; D015242:Ofloxacin / Q000493:pharmacokinetics*; D015366:Pefloxacin / Q000493:pharmacokinetics*; D011817:Rabbits; D012463:Saliva / Q000737:chemistry
D000890:Anti-Infective Agents; D015366:Pefloxacin; D002939:Ciprofloxacin; D015242:Ofloxacin
Fluorokinolonok nyálba történö kiválasztódásának vizsgálata.