Trihexyphenidyl and isoprinosine in the treatment of subacute sclerosing panencephalitis.
Six cases of subacute sclerosing panencephalitis (1 stage I, 3 stage II, 2 stage III) were diagnosed at our institution in the last 10 years. Five patients were treated with isoprinosine and the antiepileptic drug valproic acid. Three patients presented with myoclonic seizures refractory to valproic acid and the usual antiepileptic therapy. They received trihexyphenidyl with good results. We suggest the use of trihexyphenidyl in combination with isoprinosine in patients with subacute sclerosing panencephalitis with myoclonic seizures refractory to valproic acid.
Nunes
M L
ML
Division of Neurology, São Lucas Hospital, Porto Alegre, Brazil.
da Costa
J C
JC
da Silva
L F
LF
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014282:Trihexyphenidyl / Q000009:adverse effects / Q000627:therapeutic use*; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000927:Anticonvulsants; D000978:Antiparkinson Agents; D014635:Valproic Acid; D014282:Trihexyphenidyl; D007542:Inosine Pranobex