Syndrome of inappropriate antidiuretic hormone secretion in papillary serous surface carcinoma of the peritoneum.
A case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with suboptimally cytoreduced stage III papillary serous surface carcinoma of the peritoneum is described. After the primary surgery, the patient refused further therapy. Within a month bilateral pleural effusions and abdominal ascites compelled the patient to accept treatment with carboplatin and cyclophosphamide. Ten days following the chemotherapy, she was admitted in a disoriented state with serum sodium of 117-mEq/L. During the evaluation, treatment, and subsequent follow-up, the diagnosis of SIADH was confirmed. Numerous disease processes have been associated with the development of SIADH; however, there have been few reports in gynecologic malignancies. Possible etiology and clinical management of this patient are briefly discussed.
Resnik
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Division of Gynecologic Oncology, Lutheran General Hospital, Park Ridge, IL 60068, USA.
Bender
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D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001202:Ascitic Fluid / Q000209:etiology / Q000601:surgery; D016190:Carboplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018283:Cystadenocarcinoma, Papillary / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000601:surgery; D011677:Punctures
D003520:Cyclophosphamide; D016190:Carboplatin