[Structure and function of tumor suppressor genes].
Tumor suppressor genes encode molecules involved in cell adhesion, cytoplasmic signal transduction, transcriptional regulation and DNA repair. Recent studies have shown that p53 and WT1 regulate the cell cycle by altering the expression of genes involved in controlling the activity of cyclin/CDK complexes. By contrast, RB regulates the expression of genes that mediate cell cycle progression from the G1 to S phase and its activity is negatively regulated by cyclin/CDK. Recent progress in this field is summarized in the light of cell cycle control.
Akiyama
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Research Institute, for Microbial Diseases, Osaka University.
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D015870:Gene Expression; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans
D016213:Cyclins; D018844:Cyclin-Dependent Kinases