Biochemical aspects of iron metabolism, transport and regulation.
Iron metabolism in man is controlled by homeostatic mechanisms mainly based on intracellular regulation of iron uptake, utilisation and storage. Despite impressive accumulation of knowledge in recent years, the question how iron actually passes cellular membranes and how this transport process is regulated remains largely unanswered. Various models and hypotheses are discussed in context with other well established features of iron homeostasis.
Institut für Medizinische Chemie, Universität Wien.
H
H
Goldenberg
B
B
Scheiber
D018798:Anemia, Iron-Deficiency / Q000503:physiopathology; D004705:Endocytosis / Q000502:physiology; D005260:Female; D006432:Hemochromatosis / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D035925:Iron-Regulatory Proteins; D008099:Liver / Q000503:physiopathology; D008297:Male; D016601:RNA-Binding Proteins / Q000502:physiology; D011990:Receptors, Transferrin / Q000502:physiology; D014168:Transferrin / Q000502:physiology
D035925:Iron-Regulatory Proteins; D016601:RNA-Binding Proteins; D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron