Development of alternative methods.
This presentation will raise specific issues and explore areas that need discussion and development of mechanistically based tests in toxicology. In addition, an approach to validation will be presented that is based on fundamental principles and modeled after actual practice in other areas of methodology acceptance. Further, it is recognized that the validation process is but only one aspect of incorporation of in vitro approaches into safety-evaluation and risk assessment.
Center for Alternatives to Animal Testing, Johns Hopkins School of Public Health, Baltimore, Maryland 21202-6709, USA.
A M
AM
Goldberg
D000826:Animal Testing Alternatives / Q000379:methods / Q000458:organization & administration; D000818:Animals; D005060:Europe; D015203:Reproducibility of Results; D018675:Toxicity Tests / Q000379:methods; D014481:United States