Contribution of class I HLA-A2 antigen in immune reactions.
The involvement of the Class I HLA-A2 antigen is briefly reviewed in relation to allograft rejection, the feto-maternal relationship, viral cytotoxic reactions and tumor immunity. It is suggested that the HLA-A2 molecule may have, as compared to other HLA Class I alleles, a dominant role as a restricting element in cytotoxic T-cell recognition in the feto-maternal relationship to male fetuses, in specific viral infections and in tumors. As compared to other HLA Class I alleles, its reduced expression or loss in a variety of tumors suggests its possible important role in tumor immune surveillance. The disappearance of HLA-A2 from tumor cells may eventually contribute to the escape from T-cell recognition of malignant cells.
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Golda Medical Center, Petah-Tiqva, Israel.
L
L
Komlos
J
J
Hart
T
T
Klein
E
E
Livni
J
J
Notmann
D
D
Vardimon
Z
Z
Ben-Rafael
I
I
Halbrecht
D003602:Cytotoxicity, Immunologic; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D011247:Pregnancy; D012727:Sex Characteristics; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
D015789:HLA-A2 Antigen