The base excision repair pathway.
The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.
Seeberg
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E
Ecole Supérieure de Biotechnologie de Strasbourg, UPR9003 de CNRS, Unité de Cancérogenèse et de Mutagenèse Moléculaire et Structurale, Illkirch-Graffenstaden, France.
Eide
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L
Bjørås
M
M
D000225:Adenine; D000478:Alkylation; D000595:Amino Acid Sequence; D001482:Base Composition; D003596:Cytosine; D004249:DNA Damage; D004260:DNA Repair; D004706:Endodeoxyribonucleases; D006868:Hydrolysis; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009699:N-Glycosyl Hydrolases; D011687:Purines; D014498:Uracil
D011687:Purines; D014498:Uracil; D003596:Cytosine; D004706:Endodeoxyribonucleases; D009699:N-Glycosyl Hydrolases; D000225:Adenine; C030985:purine