Danger of amiodarone therapy and elevated inspired oxygen concentrations in mice.
Our study showed a statistically significant incidence of pulmonary edema in mice receiving amiodarone and 100% oxygen. This finding, together with a variety of clinical reports, indicates that in patients receiving amiodarone therapy, FiO2 should be maintained at the lowest possible level, consistent with adequate oxygenation.
Donica
S K
SK
Department of Anesthesiology, Baylor University Medical Center, Dallas, Texas 75246, USA.
Paulsen
A W
AW
Simpson
B R
BR
Ramsay
M A
MA
Saunders
C T
CT
Swygert
T H
TH
Tappe
J
J
D000638:Amiodarone / Q000009:adverse effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D008168:Lung / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000378:metabolism*; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000378:metabolism; D012119:Respiration; D014665:Vasodilator Agents / Q000009:adverse effects*
D000889:Anti-Arrhythmia Agents; D014665:Vasodilator Agents; D000638:Amiodarone; D010100:Oxygen