Cell biological analysis of the human cataractous lens: implication of lens epithelial cells in the development of aftercataract.
Lens epithelial cells (LECs) from 3 patients with congenital cataract aged 2, 4 and 12 months, respectively, were cultured. The findings were compared with those from 26 eyes of 26 patients with senile cataract, with ages ranging from 60 to 89 years. The significantly higher growth potential of LECs in patients with congenital cataract compared to those with senile cataract, seems to be the cause of the higher frequency of aftercataract following cataract surgery in infants.
Department of Ophthalmology, Fujita Health University School of Medicine, Toyoake, Japan.
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Majima
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D002386:Cataract / Q000151:congenital / Q000209:etiology* / Q000473:pathology; D002387:Cataract Extraction / Q000009:adverse effects; D002478:Cells, Cultured; D004847:Epithelial Cells; D006801:Humans; D007223:Infant; D007903:Lens Capsule, Crystalline / Q000166:cytology; D007908:Lens, Crystalline / Q000166:cytology*; D008875:Middle Aged; D011183:Postoperative Complications