Structure-activity relationships of some 4-quinazolylthiosemicarbazides and their triazolo derivatives.
Eight 4-quinazolylthiosemicarbazides and nine of their structural analogues have been tested for antibacterial effects and for structure activity relationships. 9-Chloro-5-morpholino-1,2,4-triazolo[4,3-c]quinazoline-3-thione has demonstrated the highest antibacterial effect (MIC of 1 mg/L for E. coli and P. mirabilis and < 1 mg/L for S. aureus and B. subtilis). The most effective derivatives have the carbon aromatic ring substituted with chlorine and the pyrimidine ring with morpholine or with secondary amine group.
Department of Microbiology, Biochemistry and Biology, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovakia.
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Jantová
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Hudecová
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Spirková
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Stankovský
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012663:Semicarbazides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D012663:Semicarbazides; D014230:Triazoles