Syndrome of inappropriate antidiuretic hormone secretion in papillary serous surface carcinoma of the peritoneum.
A case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with suboptimally cytoreduced stage III papillary serous surface carcinoma of the peritoneum is described. After the primary surgery, the patient refused further therapy. Within a month bilateral pleural effusions and abdominal ascites compelled the patient to accept treatment with carboplatin and cyclophosphamide. Ten days following the chemotherapy, she was admitted in a disoriented state with serum sodium of 117-mEq/L. During the evaluation, treatment, and subsequent follow-up, the diagnosis of SIADH was confirmed. Numerous disease processes have been associated with the development of SIADH; however, there have been few reports in gynecologic malignancies. Possible etiology and clinical management of this patient are briefly discussed.
Division of Gynecologic Oncology, Lutheran General Hospital, Park Ridge, IL 60068, USA.
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Resnik
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Bender
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001202:Ascitic Fluid / Q000209:etiology / Q000601:surgery; D016190:Carboplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018283:Cystadenocarcinoma, Papillary / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000601:surgery; D011677:Punctures
D003520:Cyclophosphamide; D016190:Carboplatin