Successful treatment of parvovirus B19 infection and red cell aplasia occurring after an allogeneic bone marrow transplant.
Chronic parvovirus B19 infection in the immunocompromised host may cause severe anaemia secondary to failure of erythropoiesis. This has been previously documented in patients with the Acquired Immune Deficiency Syndrome (AIDS), congenital immunodeficiencies and in children with acute lymphoblastic leukaemia during maintenance chemotherapy. We describe persistent parvovirus infection in a 14-year-old boy after HLA-matched sibling allogeneic bone marrow transplantation for acute lymphoblastic leukaemia in second remission.
Corbett
T J
TJ
Department of Haematology, Royal Free Hospital School of Medicine, London, UK.
Saw
H
H
Popat
U
U
MacMahon
E
E
Cohen
B J
BJ
Knowles
W A
WA
Beard
S
S
Prentice
H G
HG
D000293:Adolescent; D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D014184:Transplantation, Homologous
D004279:DNA, Viral