Cloning and sequencing of a tpr-met oncogene cDNA isolated from MNNG-transformed human XP fibroblasts.
A rearranged tpr-met oncogene was identified in a MNNG-transformed human Xeroderma pigmentosum (XP) cell line (ASKMN). A 2016 bp cDNA was cloned and sequenced, disclosing an ORF with a coding capacity for a 523 aa protein. The sequence of this tpr-met cDNA was very similar to that previously reported in another human MNNG-transformed cell line (MNNG-HOS).
C.N.R.S., Institut de Recherches sur le Cancer, Villejuif, France.
R
R
Wicker
A
A
Bounacer
A
A
Gascon
O
O
Brison
A
A
Sarasin
H G
HG
Suárez
D000595:Amino Acid Sequence; D001483:Base Sequence; D002461:Cell Line, Transformed; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000096:biosynthesis / Q000302:isolation & purification*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008769:Methylnitronitrosoguanidine; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000235:genetics*
D018076:DNA, Complementary; D015514:Oncogene Proteins, Fusion; D008769:Methylnitronitrosoguanidine