Recurrent meningococcal septicaemia and properdin deficiency.
A 32-year-old male presented with two episodes of meningococcal septicaemia, each of which was caused by a different serogroup of Neisseria meningitidis. Examination of the alternative pathway of complement revealed the rare X-linked disorder properdin deficiency (PD). Meningococcal Infection in complement deficiency states is discussed and the unusual features of this case are highlighted.
Department of Infectious Diseases and Tropical Medicine, (Monsall Unit) North Manchester General Hospital, Crumpsall, U.K.
N A
NA
Cunliffe
N
N
Snowden
E M
EM
Dunbar
M R
MR
Haeney
D000328:Adult; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008589:Meningococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000302:isolation & purification*; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D011414:Properdin / Q000172:deficiency*
D010406:Penicillins; D011414:Properdin; D010400:Penicillin G