[Role of glycosoaminoglycans in venous disease. Mode of action of some flavonoid drugs].
Varicose vein walls differ from normal venous walls by an important loss of their collagen content and an increase of their glycosaminoglycan content, essentially of hyaluronan. The decrease in fibrous protein content can be attributed to increased proteolytic (collagenolytic) activity as well as to free radicals. Glycosaminoglycan increase reflects a disregulation of the normal program of matrix biosynthesis by the cells of varicose vein wall, essentially smooth muscle cells. Some flavonoid drugs are capable of correcting these deviations by decreasing proteolytic attack on fibrous proteins and the accumulation of proteoglycans and hyaluronan. These effects, due to interactions between flavonoid drugs and the cells and fibrous proteins of the venous wall differ according to the nature of such drugs. A hypothesis is proposed to explain these differences in the intensity of action of flavonoid drugs with apparently closely related structures, based on the conformation of these drugs and their interaction with the triple helical structure of collagen fibers as well as with the cell membranes.
Laboratoire de Biologie Cellulaire, Université Paris VII, France.
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Drubaix
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Viljanen-Tarifa
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Robert
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Robert
D000959:Antihypertensive Agents / Q000737:chemistry / Q000627:therapeutic use; D044946:Biflavonoids; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000737:chemistry / Q000378:metabolism*; D044945:Proanthocyanidins; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism; D014648:Varicose Veins / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
D000959:Antihypertensive Agents; D044946:Biflavonoids; D005419:Flavonoids; D006025:Glycosaminoglycans; D044945:Proanthocyanidins; D011509:Proteoglycans; C017674:procyanidin; D002392:Catechin; D006820:Hyaluronic Acid
Rôle des glycosaminoglycannes dans la maladie veineuse. Mode d'action de médicaments flavonoïdes.