[The effect of adenosine on the hypothalamo-hypophyseal-adrenal system].
The effect of various doses of intraperitoneally administered adenosine on the content of corticotropin and corticosteroids on the blood plasma was studied in Wistar rats. Dependence of the effect exerted by adenosine on the hypothalamo-pituitary-adrenal system on its dose was demonstrated: 1 hour after nucleoside administration in a dose of 50 mg/kg corticotropin concentration increased; 1 hour after adenosine administration in a dose of 25 mg/kg the level of corticosteroids in the blood plasma decreased.
Kononenko
V Ia
VIa
Pil'kevych
L I
LI
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000241:Adenosine / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D015062:11-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone; D000241:Adenosine
Vplyv adenozynu na hipotalamo-hipofizarno-nadnyrkovu systemu.