Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1.
In the course of isolation and sequence analysis of microsatellite repeat containing human cDNAs, we have isolated the human homologue of the rat visinin-like peptide gene. The human gene shows a high degree of conservation at both the amino acid and the DNA sequence level. The (CA)n microsatellite repeat embedded in the 3' untranslated region of the gene is conserved between rat and human, along with the flanking DNA sequences. We have mapped the VSNL1 gene to the short arm of chromosome 2.
Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
M H
MH
Polymeropoulos
S
S
Ide
M B
MB
Soares
G G
GG
Lennon
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D017124:Conserved Sequence; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D018076:DNA, Complementary; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D051596:Neurocalcin; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D051381:Rats; D044169:Receptors, Calcium-Sensing; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D002135:Calcium-Binding Proteins; D017931:DNA Primers; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D051596:Neurocalcin; D044169:Receptors, Calcium-Sensing; C496688:VSNL1 protein, human; C496690:Vsnl1 protein, rat; D004247:DNA