Electrotonic coupling between two CA3 hippocampal pyramidal neurons: a distributed cable model with somatic gap-junction.
A model of a pair of electrotonically coupled CA3 hippocampal pyramidal neurons is presented. Each neuron is represented by a tapered equivalent cable attached to an isopotential soma. The synaptic potential in a neuron soma is determined as a consequence of electrical coupling to another soma that receives a synaptic input on its dendritic tree. Estimates of the coupling resistances, soma input resistances and soma-to-dendritic tree conductance ratio show that a substantial current may arise in a neuron as a consequence of synaptic activity in a neuron coupled to it. The small increase in decay time due to coupling in the model indicates that actual coupling is between more than just pairs of neurons.
The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW, Australia.
R R
RR
Poznanski
W G
WG
Gibson
M R
MR
Bennett
D000818:Animals; D002450:Cell Communication; D017629:Gap Junctions / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D008322:Mammals; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology