Auditory and vestibular functions after single or combined exposure to toluene: a review.
Toluene is a widely used organic solvent, heavily employed in many manufacturing industries. Recently, evidence has begun to accumulate on the deleterious effect of toluene exposure has on the auditory and vestibular systems. Although little published information exists regarding these effects, the reported findings indicate a need for further investigation. The results of such investigations may dramatically affect occupational hearing conservation practices and legislation. Both human and animal studies will be summarized in discussing the effects of toluene alone or in combination with noise or other chemicals. Gaps in scientific knowledge are highlighted to assist future research.
Morata
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National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226-1998, USA.
Nylén
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Johnson
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Dunn
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D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D004195:Disease Models, Animal; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D016273:Occupational Exposure; D012997:Solvents / Q000009:adverse effects*; D014050:Toluene / Q000009:adverse effects*; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D012997:Solvents; D014050:Toluene