[Effect of GH/IGF-I deficiency on bone and collagen turnover in children and adults with GH deficiency].
Serum bone Gla protein (BGP), marker of osteoblastic function, carboxyterminal cross-linked telopeptide of type I collagen (ICTP), index of bone resorption, and aminoterminal propeptide of type III procollagen, marker of collagen synthesis, were evaluated in children with GH deficiency (GHD), in adults with childhood-onset GHD and in adults with acquired GHD in adultlife. In children with GHD, serum BGP (12.7 +/- 0.5 ng/ml), ICTP (8.5 +/- 0.9 ng/ml) and PIIINP (3.4 +/- 0.4 ng/ml) were significantly lower (p < 0.0001, p < 0.0001 and p < 0.001, respectively) than those observed in a sex and age matched control group (BGP:18.9 +/- 0.9 ng/ml, ICTP: 14.4 +/- 0.6 ng/ml, PIIINP: 6.7 +/- 0.7 ng/ml). In adults with childhood onsed GHD, BGP levels (3.7 +/- 0.4 ng/ml) were significantly lower (p < 0.0001) than those recorded in a sex and age matched control group (5.4 +/- 0.1 ng/ml), while ICTP (4.7 +/- 0.7 ng/ml) and PIIINP (3.7 +/- 0.5 ng/ml) levels were similar to those found in controls (ICTP: 4.1 +/- 0.3 ng/ml; PIIINP: 3.3 +/- 0.2 ng/ml). In adults with acquired GHD, serum BGP (5.3 +/- 0.4 ng/ml), ICTP (3.8 +/- 0.4 ng/ml) and PIIINP (3.6 +/- 0.3 ng/ml) levels were not significantly different from those recorded in controls (BGP: 5.4 +/- 0.1 ng/ml, ICTP: 4.1 +/- 0.3 ng/ml, PIIINP: 3.3 +/- 0.2 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Laboratorio Sperimentale di Ricerche Endocrinologiche, Centro Auxologico Italiano, IRCCS, Milano.
A
A
Sartorio
A
A
Conti
M
M
Monzani
S
S
Ferrero
O
O
Biella
G
G
Casati
G
G
Faglia
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016723:Bone Remodeling / Q000502:physiology*; D002648:Child; D003094:Collagen / Q000097:blood* / Q000502:physiology*; D024042:Collagen Type I; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*
D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide; D015675:Osteocalcin; D013006:Growth Hormone; D003094:Collagen
Effetti della carenza di GH/IGF-I sul turnover osseo e collagene in bambini ed adulti con deficit di GH.