Optical resolution of 1-arylethanols with a condensed aromatic ring by lipase from Pseudomonas aeruginosa.
Enantioselective syntheses of both enantiomers of 1-arylethanols with a condensed aromatic ring have been done through acetylation of the racemic alcohols with vinyl acetate in the presence of a lipase from Pseudomonas aeruginosa (Toyobo, LIP). The lipase LIP showed high enantioselectivity and reactivity for the title compounds, reacted acetates, and remaining alcohols were obtained with high optical purity.
Department of Chemistry, National Industrial Research Institute of Nagoya, Japan.
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K
Kato
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Katayama
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Fujii
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Kimoto
D000107:Acetylation; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000031:analogs & derivatives / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D013055:Spectrophotometry, Infrared
D000431:Ethanol; D008049:Lipase