[Sensibility and specificity of N-myc oncogene with respect to other prognostic factors in 15 neuroblastomas].
Several biologic features of tumor cells correlate closely with a favorable or unfavorable outcome. To aid in assessing correlation in the various number of prognostic factors including the age, stage, VMA/HVA ratios, and the serum levels of NSE and ferritin, the histopathological features, ploidy, partial monosomy for the short arm of chromosome 1, and the tumor N-myc gene copy number, are examined. We determined the sensitivity and specificity of classical markers above the amplification of the N-myc oncogene. A striking new observation is the positive correlation between genomic amplification and some prognostic factors (stage, ferritin, NSE, pathologic anatomy and 1p deletion.
Queizán
A
A
Departamento de Cirugía Pediátrica, Hospital Infantil La Paz, Madrid.
García-Miguel
P
P
Belló
M J
MJ
Castresana
J C
JC
Rey
J A
JA
Pestaña
A
A
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D005293:Ferritins / Q000097:blood; D005784:Gene Amplification; D016259:Genes, myc; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes; D011003:Ploidies; D011379:Prognosis; D014642:Vanilmandelic Acid / Q000097:blood
D014642:Vanilmandelic Acid; D005293:Ferritins; D006719:Homovanillic Acid
Sensibilidad y especificidad del oncogén N-myc con respecto a otros factores de pronóstico en 15 neuroblastomas.