Efficient removal of albumin-bound furancarboxylic acid by protein-leaking hemodialysis.
Furancarboxylic acid (3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF), an inhibitor of erythropoiesis, cannot be removed by conventional hemodialysis due to its strong albumin binding, resulting in its accumulation in uremic serum. We used protein-leaking hemodialysis with BK-F dialyzers in 8 uremic patients for 4 months to determine its effect on the serum levels of CMPF. Pre-hemodialysis serum levels of CMPF significantly decreased to about 50% after 4 months by protein-leaking hemodialysis, while those of BUN and serum creatinine did not change significantly. Pre-hemodialysis hematocrit and hemoglobin levels significantly increased by protein-leaking hemodialysis. These results indicate that protein-leaking hemodialysis reduces serum levels of albumin-bound CMPF and improves anemia.
Nagoya University Branch Hospital, Japan.
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T
Niwa
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H
Asada
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S
Tsutsui
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T
Miyazaki
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000517:prevention & control; D001806:Blood Urea Nitrogen; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood; D005260:Female; D005663:Furans / Q000097:blood*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011422:Propionates / Q000097:blood*; D011485:Protein Binding; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods; D012709:Serum Albumin / Q000378:metabolism*; D014511:Uremia / Q000097:blood / Q000628:therapy*
D005663:Furans; D006454:Hemoglobins; D008567:Membranes, Artificial; D011422:Propionates; D012709:Serum Albumin; C041693:3-carboxy-4-methyl-5-propyl-2-furanpropionic acid; D003404:Creatinine