Identification of an anaerobically induced phosphoenolpyruvate-dependent fructose-specific phosphotransferase system and evidence for the Embden-Meyerhof glycolytic pathway in the heterofermentative bacterium Lactobacillus brevis.
Heterofermentative gram-positive bacteria are believed to metabolize sugars exclusively via the pentose phosphoketolase pathway following uptake via sugar:cation symport. Here we show that anaerobic growth of one such bacterium, Lactobacillus brevis, in the presence of fructose induces the synthesis of a phosphotransferase system and glycolytic enzymes that allow fructose to be metabolized via the Embden-Meyerhof pathway.
Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
M H
MH
Saier
J J
JJ
Ye
S
S
Klinke
E
E
Nino
D000332:Aerobiosis; D000693:Anaerobiosis; D001426:Bacterial Proteins; D005285:Fermentation; D005632:Fructose / Q000378:metabolism*; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006019:Glycolysis; D007778:Lactobacillus / Q000201:enzymology* / Q000378:metabolism; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism*; D010732:Phosphofructokinase-1 / Q000378:metabolism
D001426:Bacterial Proteins; D005632:Fructose; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; C030182:phosphocarrier protein HPr; D010732:Phosphofructokinase-1; C068652:1-phosphofructokinase; D005634:Fructose-Bisphosphate Aldolase