Distribution of the mammalian Stat gene family in mouse chromosomes.
Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.
Copeland
N G
NG
Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
Gilbert
D J
DJ
Schindler
C
C
Zhong
Z
Z
Wen
Z
Z
Darnell
J E
JE
Mui
A L
AL
Miyajima
A
A
Quelle
F W
FW
Ihle
J N
JN
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D008322:Mammals / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D005810:Multigene Family; D009115:Muridae / Q000235:genetics*; D015345:Oligonucleotide Probes; D015183:Restriction Mapping; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
D015345:Oligonucleotide Probes; D014157:Transcription Factors