Influence of age, treadmill running, and food restriction on plasma fibrinogen concentration and expression of gamma chain mRNA in female Sprague-Dawley rats.
Plasma fibrinogen concentration and expression of mRNA encoding the gamma-chain of fibrinogen were determined in female Sprague-Dawley rats aged 10, 21 and 30 months. Both parameters increased significantly with age in a parallel fashion. Food restriction was able to reduce the age-dependent increase of both plasma concentration and gene expression to levels below young controls. On the other hand, long-term treadmill running failed to influence the plasma fibrinogen concentration. From these results we conclude that the plasma fibrinogen concentration increases with age due to an increased fibrinogen biosynthesis.
Chair of Internal Medicine-Gerontology, University of Erlangen-Nürnberg, Germany.
H
H
Dorner
B
B
Fischer
G
G
Seefried
D
D
Platt
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D004586:Electrophoresis; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis*; D005508:Food Deprivation / Q000502:physiology*; D008099:Liver / Q000473:pathology; D009043:Motor Activity / Q000502:physiology*; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D012333:RNA, Messenger; D005340:Fibrinogen