NAD glycohydrolases and the metabolism of cyclic ADP-ribose.
Cyclic ADP-ribose is a recently discovered metabolite of NAD that functions in cellular calcium signalling. The discovery that NAD glycohydrolases can catalyze the synthesis and hydrolysis of cyclic ADP-ribose has renewed interest in this class of ADP-ribose transferring enzymes that were discovered over 50 years ago.
Jacobson
M K
MK
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 76107, USA.
Cervantes-Laurean
D
D
Strohm
M S
MS
Coyle
D L
DL
Bummer
P M
PM
Jacobson
E L
EL
D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D036563:Cyclic ADP-Ribose; D006801:Humans; D009243:NAD / Q000378:metabolism*; D009244:NAD+ Nucleosidase / Q000378:metabolism*; D015398:Signal Transduction
D009243:NAD; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D009244:NAD+ Nucleosidase; D002118:Calcium