[Sensibility and specificity of N-myc oncogene with respect to other prognostic factors in 15 neuroblastomas].
Several biologic features of tumor cells correlate closely with a favorable or unfavorable outcome. To aid in assessing correlation in the various number of prognostic factors including the age, stage, VMA/HVA ratios, and the serum levels of NSE and ferritin, the histopathological features, ploidy, partial monosomy for the short arm of chromosome 1, and the tumor N-myc gene copy number, are examined. We determined the sensitivity and specificity of classical markers above the amplification of the N-myc oncogene. A striking new observation is the positive correlation between genomic amplification and some prognostic factors (stage, ferritin, NSE, pathologic anatomy and 1p deletion.
Departamento de Cirugía Pediátrica, Hospital Infantil La Paz, Madrid.
A
A
Queizán
P
P
García-Miguel
M J
MJ
Belló
J C
JC
Castresana
J A
JA
Rey
A
A
Pestaña
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D005293:Ferritins / Q000097:blood; D005784:Gene Amplification; D016259:Genes, myc; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes; D011003:Ploidies; D011379:Prognosis; D014642:Vanilmandelic Acid / Q000097:blood
D014642:Vanilmandelic Acid; D005293:Ferritins; D006719:Homovanillic Acid
Sensibilidad y especificidad del oncogén N-myc con respecto a otros factores de pronóstico en 15 neuroblastomas.