Mesalazine induced exacerbation of ulcerative colitis.
5-Aminosalicylic acid (5-ASA) compounds occasionally exacerbate diarrhoea in patients with inflammatory bowel disease. This is thought to be due to a secretory mechanism in most cases. A patient with presumed intolerance to sulphasalazine and 5-ASA preparations who developed endoscopic and histological evidence of disease relapse after a rectal challenge with mesalazine is reported.
Department of Gastroenterology, Royal Gwent Hospital, Newport.
K C
KC
Kapur
G T
GT
Williams
M C
MC
Allison
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000139:chemically induced* / Q000473:pathology; D012809:Colon, Sigmoid / Q000473:pathology; D006801:Humans; D008297:Male; D019804:Mesalamine; D012008:Recurrence
D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine