SOS-regulated proteins in translesion DNA synthesis and mutagenesis.
Studies of Escherichia coli have revealed that most mutagenesis resulting from exposure to UV radiation and various chemicals (SOS mutagenesis) requires the operation of a specialized system involving the UmuD', UmuC, RecA and DNA polymerase III proteins, which allows translesion synthesis to occur on damaged DNA templates. The SOS mutagenesis system is induced by DNA damage and is subject to elaborate regulatory control involving both transcriptional derepression and post-translational activation and inhibition. The implications of the E. coli SOS mutagenesis system for mutagenesis in other organisms are discussed.
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
G C
GC
Walker
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D004247:DNA / Q000096:biosynthesis*; D004258:DNA Polymerase III / Q000235:genetics; D004259:DNA-Directed DNA Polymerase; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016296:Mutagenesis; D014176:Protein Biosynthesis; D011938:Rec A Recombinases / Q000235:genetics; D013014:SOS Response, Genetics
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D004247:DNA; C078202:UmuC protein, E coli; D011938:Rec A Recombinases; D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase; C055218:UmuD protein, E coli