[A case report of prostate cancer with Paneth cell-like change].
We report one case of Paneth cell-like change of prostate cancer. An 81-year-old male reported to our hospital with the chief complaint of urinary retention. The serum concentration of prostate specific antigen, 168 ng/ml, was high, and digital examination was performed. Because we suspected prostate cancer, needle biopsy of the prostate was performed. Histological examination revealed moderately-poorly differentiated adenocarcinoma. Computed tomography revealed no invasion to the prostatic wall and no metastasis to the lymph node. 99mTc-HMDP revealed no bone metastasis. We chose intravenous hormonotherapy (fosfestrol 500 mg/day, 20 days), but urinary retention did not improve. Therefore, we performed transurethral prostatectomy to improve the symptoms. Histological examination of the removed specimen revealed moderately differentiated adenocarcinoma with Paneth cell-like change. Immunochemical and histochemical stains were positive for Grimelius, serotonin and prostatic acid phosphatase and negative for periodic acid-Schiff reaction, lysozyme, neuron specific enolase, prostate specific antigen, alpha-1-antitrypsin and IgA.
Department of Urology, Health Insurance Hazu Hospital.
N
N
Soga
R
R
Suzuki
Y
Y
Komeda
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*
D000970:Antineoplastic Agents; D004054:Diethylstilbestrol; C004955:fosfestrol