Administration of the plasticizer di (2-ethylhexyl) phthalate alters glycoconjugate profile.
This study was undertaken to evaluate the level of glycoproteins and sialic acid in rats fed di (2-ethylhexyl)-phthalate (DEHP) in the diet for 24 weeks. Protein-bound hexose, hexosamine and sialic acid were increased in plasma and liver of rats treated with DEHP, whereas the erythrocyte membrane showed a reduction following DEHP administration. Evaluation of glycoproteins is a useful indicator of the carcinogenic process. It is suggested that profound alterations in membrane components observed in the present study may be related to the carcinogenic potential of DEHP.
Selvam
S
S
Department of Biochemistry, Annamalai University, Annamalainagar.
Nagini
S
S
D000818:Animals; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006595:Hexosamines / Q000097:blood / Q000378:metabolism; D006601:Hexoses / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010968:Plasticizers / Q000633:toxicity*; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000097:blood / Q000378:metabolism
D006023:Glycoproteins; D006595:Hexosamines; D006601:Hexoses; D010968:Plasticizers; D012794:Sialic Acids; D004051:Diethylhexyl Phthalate