[The role of vascular nitric oxide (NO) in the pathomechanism of pre-eclampsia].
The significance of nitric-oxide as a biological mediator is increasingly elucidated in various physiological processes. In addition to the endothelium dependent vasodilator effect it also plays an important role as a neurotransmitter. Possible synthesis of endothelial nitric-oxide is an essential factor in the regulation of blood pressure and utero-placental circulation. Recently the relationship of nitric-oxide and preeclampsia has extensively been studied. The results of human studies and animal experiments suggest that insufficient production of endothelial nitric-oxide probably has an important role in the pathomechanism of preeclampsia.
Visontai
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I. sz. Szülészeti és Nógyógyászati Klinika. Semmelweis Orvostudományi Egyetem, Budapest.
Rigó
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J
Dézsi
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D000818:Animals; D004727:Endothelium / Q000378:metabolism*; D005260:Female; D006801:Humans; D018377:Neurotransmitter Agents; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000097:blood; D011225:Pre-Eclampsia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D014665:Vasodilator Agents
D018377:Neurotransmitter Agents; D014665:Vasodilator Agents; D009569:Nitric Oxide
A vascularis nitrogén-oxid (NO) szerepe a praeeclampsia patomechanizmusában.