The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies.
The small GTP-binding proteins Rac and Rho are key control elements in the reorganization of the actin cytoskeleton induced by growth factors or oncogenic Ras. It has been established recently that Rac and Rho also play a crucial role in Ras transformation. This suggests that the elements in the pathways regulated by Rac and Rho are valid targets for cancer therapy. Several important components of those signaling pathways have now have identified.
Symons
M
M
Onyx Pharmaceuticals, Richmond, USA.
D000818:Animals; D001709:Biotechnology; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D003599:Cytoskeleton / Q000378:metabolism; D015195:Drug Design; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology*; D011905:Genes, ras / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D012234:Rho Factor / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D020744:rac GTP-Binding Proteins
D012234:Rho Factor; D014157:Transcription Factors; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins