Crossbridge dynamics in muscle contraction.
The study deals with the description of muscle contraction based on biochemical studies and describes four major approaches for coupling calcium kinetics with crossbridge (Xb) cycling. The analysis illuminates two controversial points: 1) the relationship between Xb attachment/detachment and Xb cycling, i.e., the transition between weak to strong conformations, and 2) the effect of calcium on Xb function: does it regulate Xb kinetics or Xb recruitment.
Julius Silver Institute, Department of Biomedical Engineering, Technion-IIT, Haifa, Israel.
A
A
Landesberg
R
R
Beyar
S
S
Sideman
D000818:Animals; D002118:Calcium / Q000502:physiology*; D006801:Humans; D008962:Models, Theoretical; D009200:Myocardial Contraction / Q000502:physiology*
D002118:Calcium