[Changes in plasma cytokine levels during lung surgery].
We studied the changes in plasma cytokine (IL-6 and IL-8) levels during lung surgery in 20 patients. The correlation between the changes in cytokine levels and surgical stress as well as the postoperative complications were examined. The levels of IL-6 and IL-8 increased shortly after the surgical incision and were 326 pg.ml-1 and 61 pg.ml-1 respectively, at the end of surgery. The changes in cytokine levels correlated well with the duration of surgery, blood loss and CPR levels for 2 days after the surgery. However, there were no severe postoperative complications in the present study. We conclude that the cytokines increase shortly after the surgical incision and the changes in cytokine levels correlate well with the surgical stress.
Taniguchi
T
T
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University.
Matsumoto
Y
Y
Yoneda
T
T
Mori
I
I
Kobayashi
H
H
Yamamoto
K
K
D000210:Acute-Phase Reaction / Q000097:blood; D000368:Aged; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D007432:Intraoperative Period; D008168:Lung / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000097:blood
D015850:Interleukin-6; D016209:Interleukin-8