Furazolidone toxicosis in young broiler chicks: morphometric and pathological observations on heart and testes.
Broiler chicks 1 d and 3 w of age were given 0, 400, 800, or 1000 mg furazolidone (Fz)/kg feed for 4 w. Bi-ventricular heart dilatation (as measured by increases in ventricular diameter and thinning of the ventricular walls) was present in 1-d-old chicks fed 800 mg Fz, whereas in 3-w-old groups these changes occurred at 1000 mg Fz. There was no heart hypertrophy. Microscopic changes in the heart were not discernible in and Fz-fed birds. The liver had congestion and cytoplasmic vacuolation of hepatocytes. About 37-50% of the male birds in the different Fz-fed groups had testicular degeneration varying from mild to cystic enlargement. The degenerated testes had dilatation of seminiferous tubules; in cystic testes the seminiferous tubules were extremely dilated and had flattened epithelium. The interstitial tissue between the dilated tubules was compressed and atrophic.
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
M Z
MZ
Khan
Q
Q
Zaman
N
N
Islam
G
G
Muhammad
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity*; D002645:Chickens; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D004108:Dilatation, Pathologic / Q000139:chemically induced / Q000662:veterinary; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005664:Furazolidone / Q000008:administration & dosage / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000473:pathology*; D011201:Poultry Diseases / Q000139:chemically induced; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D000890:Anti-Infective Agents; D005664:Furazolidone