Effect of isolation on behavioural models involving serotonergic 5-HT2 and 5-HT1A receptors.
1. The effect of 7 days of isolation were observed in mice on behavioural models involving 5-HT2 and 5-HT1A receptors. 2. The sensitivity of 5-HT2 receptors as assessed through L-5-HTP or 5-MeODMT induced head-twitches was reduced. 3. The sensitivity of the 5-HT1A receptors implicated in the 8-OH-DPAT induced feeding was unchanged. 4. The sensitivity of the 5-HT1A receptors involved in the 8-OH-DPAT induced hypothermia was diminished. 5. On the whole, these results show that after 7 days of isolation, the responses to the stimulation of serotonergic receptors is unchanged or diminished according to both the receptor's subtype and the model used.
INSERM U26, Hopital Fernand Widal, Paris, France.
J P
JP
Coudereau
C
C
Monier
H
H
Frances
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D007035:Hypothermia; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011985:Receptors, Serotonin / Q000145:classification* / Q000378:metabolism*; D012934:Social Isolation; D013997:Time Factors
D011985:Receptors, Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin