[Successful treatment of splenomegaly and anemia by VP therapy in idiopathic myelofibrosis complicated with acromegaly: a case report].
Here we report a 65-year-old male patient with idiopathic myelofibrosis (IMF) accompanied with acromegaly. He was admitted because of anemia and splenomegaly. No favorable effects were observed when hydroyurea was administered. However, his symptoms were successfully treated by administration of vincristine and prednisolone (VP therapy), which is usually applied for choronic myelogenous leukemia in the accelerated phase. Therefore, VP therapy might be one possible for IMF. Since there have been several reports suggesting the possible association of hematological malignancies with acromegaly, we speculate that acromegaly was implicated in the initiation or progression of IMF in this case.
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
Y
Y
Imai
N
N
Akiyama
Y
Y
Hanazono
K
K
Inamori
K
K
Mitani
H
H
Hirai
R
R
Nagai
Y
Y
Yazaki
D000172:Acromegaly / Q000150:complications*; D000368:Aged; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D055728:Primary Myelofibrosis / Q000150:complications / Q000188:drug therapy*; D013163:Splenomegaly / Q000188:drug therapy* / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D011239:Prednisolone