M-caveolin, a muscle-specific caveolin-related protein.
Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells. The best-characterised caveolar protein is the integral membrane protein, VIP21-caveolin. We now describe a novel homologue of VIP21-caveolin, M-caveolin, which is expressed exclusively in muscle. M-caveolin was shown to be expressed in differentiated myotubes but not myoblasts. Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin. M-caveolin may play a specialised role in the caveolae of muscle cells.
European Molecular Biology Laboratory, Heidelberg, Germany.
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000737:chemistry; D051242:Caveolin 1; D051244:Caveolin 3; D022461:Caveolins; D002454:Cell Differentiation / Q000235:genetics; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D005455:Fluorescent Antibody Technique; D015870:Gene Expression / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D051379:Mice; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000737:chemistry*; D018482:Muscle, Skeletal / Q000737:chemistry*; D051381:Rats; D016415:Sequence Alignment; D017421:Sequence Analysis
C495540:CAV1 protein, human; D002352:Carrier Proteins; C495541:Cav1 protein, mouse; C495537:Cav1 protein, rat; C495548:Cav3 protein, mouse; C495549:Cav3 protein, rat; D051242:Caveolin 1; D051244:Caveolin 3; D022461:Caveolins; D008565:Membrane Proteins; D009124:Muscle Proteins