The appearance of active plasminogen activator of urokinase type (u-PA) in the rabbit anterior eye segment irradiated by UVB rays. A histochemical and biochemical study.
Repeated irradiation of the rabbit eye with UV rays of 312 nm wavelength (UVB) evoked the appearance of active plasminogen activator of urokinase type (u-PA) in the anterior eye segment. Using histochemistry, active u-PA appeared first in the corneal epithelium followed by the corneal endothelium, inflammatory cells in the corneal stroma and the lens epithelium. With a semiquantitative fluorescent method active u-PA was also found in the tear fluid and aqueous humour. UV rays of 365 nm wavelength (UVA) under the same conditions did not cause the appearance of active u-PA in the anterior eye segment.
Cejková
J
J
Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Prague 4, Czech Republic.
Lojda
Z
Z
D000595:Amino Acid Sequence; D000818:Animals; D000869:Anterior Eye Segment / Q000201:enzymology* / Q000528:radiation effects*; D001082:Aqueous Humor / Q000201:enzymology / Q000528:radiation effects; D006651:Histocytochemistry; D008969:Molecular Sequence Data; D011817:Rabbits; D013666:Tears / Q000201:enzymology / Q000528:radiation effects; D014466:Ultraviolet Rays; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis* / Q000528:radiation effects*
D014568:Urokinase-Type Plasminogen Activator