Serum cortisol levels in children with dengue haemorrhagic fever.
Dengue Haemorrhagic Fever (DHF) is a serious and often fatal paediatric problem in Myanmar. Acute and convalescent serum cortisol levels were measured in 62 children with dengue infection to study cortisol sufficiency in this disease. Twenty-six children with non-dengue acute viral infection were also included as controls. In acute stage, highest mean serum cortisol level (655.4 +/- 72.18 nmol/l) was observed in DHF cases presenting with shock, followed by DHF non-shock cases (640.56 +/- 74.58 nmol/l) and dengue fever cases (617.2 +/- 75.38 nmol/l). Cases with DHF had significantly higher serum cortisol level (P < 0.05) than in controls (444.41 +/- 59.71 nmol/l). In cases of DHF, mean serum cortisol level during the acute stage was found to be significantly two-fold higher than the convalescent stage. We found no cortisol insufficiency in cases of dengue haemorrhagic fever during acute and convalescent stages of illness.
Department of Medical Research, Yangon, Union of Myanmar.
Myo-Khin
Soe-Thein
Thein-Thein-Myint
Than-Nu-Swe
Tin-Tin-Saw
Muya-Than
D000208:Acute Disease; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D002052:Myanmar; D011446:Prospective Studies; D012769:Shock / Q000097:blood / Q000209:etiology; D018709:Statistics, Nonparametric
D006854:Hydrocortisone