[Three cases of uterine cervical adenocarcinoma successfully treated by neoadjuvant chemotherapy with continuous intra-arterial infusion (cisplatin, 5-fluorouracil)].
Low-dose consecutive intra-arterial infusion therapy with cisplatin and 5-fluorouracil as neoadjuvant chemotherapy was performed on 3 cases of cervical adenocarcinoma (two stage IIb and one stage IIIb). Ten-day infusion of cisplatin 10 mg/day (one shot) and 5-fluorouracil 250 mg/day (continuous) into blood flow-altered bilateral internal iliac arteries, was carried out as one course and 2 times at intervals of 3 weeks. As a result, side effects were slight, and all of these 3 cases showed a tumor diminution rate of above 83.5%, making it possible to perform complete tumorectomy through radical hysterectomy. However, some postoperative additional treatment was thought to be necessary, considering that with the present method, the area under the curve of free Pt of cubital venous blood is 2.4 mg hr/l and that by the present method alone long-term survival cannot be expected in cervical adenocarcinoma.
Nagato General Hospital.
A
A
Narimatsu
O
O
Okada
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007044:Hysterectomy; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery
D002945:Cisplatin; D005472:Fluorouracil