High-performance liquid chromatographic determination of iobitridol in plasma, urine and bile.
Iobitridol is a new non-ionic, low-osmolality contrast medium for urography and angiography. We have developed a method for determining iobitridol in body fluids using high-performance liquid chromatography with ultraviolet detection. The method, which is specific and reproducible, does not require an internal standard. Determinations can be carried out in body fluids against a set of standards in ethanol. The method was validated for the quantification of iobitridol in biological samples obtained during pharmacokinetic studies.
Laboratoire Guerbet, Roissy Charles de Gaulle, France.
P
P
Bourrinet
H
H
Feldman
A
A
Dencausse
C
C
Chambon
B
B
Bonnemain
D000818:Animals; D001646:Bile / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000032:analysis*; D004285:Dogs; D007472:Iohexol / Q000031:analogs & derivatives* / Q000032:analysis; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet
D003287:Contrast Media; C093233:iobitridol; D007472:Iohexol