Acute renal failure after exercise in a child with renal hypouricemia.
We describe a 15 year old boy with renal hypouricemia who developed acute renal failure after a school athletics meeting, accompanied by appendicitis. During acute renal failure, the highest level of uric acid was 5.0 mg/dL, creatinine 7.9 mg/dL and urea nitrogen 58.6 mg/dL. After recovery, the serum uric acid fell to 0.9 mg/dL and the fractional excretion of uric acid (FEuA) exceeded the normal range. The probenecid and pyrazinamide tests showed that the patient had a total defect of uric acid reabsorption. This case suggested that strenuous exercise could be responsible for acute renal failure in patients with renal hypouricemia.
Department of Pediatrics, Kochi Medical School, Nanokoku-city, Japan.
M
M
Fujieda
W
W
Yokoyama
N
N
Oishi
T
T
Okada
T
T
Kurashige
G
G
Hamada
D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D001064:Appendicitis / Q000150:complications; D015444:Exercise; D006801:Humans; D008297:Male; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid