NMR characterization of guanine DNA site alkylated by kapurimycin A3, an antitumour antibiotic from Streptomyces sp.
The kapurimycin A3-guanine adduct was formed by alkylation of the antitumour antibiotic with d(CGCG)2. The site of alkylation of the guanine was confirmed by comparative NMR studies with N-7-methyl-guanine in DMSO-d6.
School of Pharmnaceutical Sciences, University of Science Malaysia, Penang, Malaysia.
K L
KL
Chan
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H
Sugiyama
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I
Saito
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M
Hara
D000478:Alkylation; D000873:Anthracenes / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001665:Binding Sites; D004247:DNA / Q000187:drug effects* / Q000378:metabolism*; D004249:DNA Damage; D006147:Guanine / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011753:Pyrones / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013302:Streptomyces / Q000737:chemistry
D000873:Anthracenes; D000903:Antibiotics, Antineoplastic; D011753:Pyrones; C066903:kapurimycin A3; D006147:Guanine; D004247:DNA