[The experimental validation of methods for the emergency immunoprophylaxis of gas gangrene].
The effectiveness, both immunological (by an increase in the titers of antitoxins) and protective (by resistance to the inoculation of the absolute lethal dose of infective agents), of the regional (wound) revaccination with tetratoxoid (Clostridium perfringens, C. oedematiens, C. septicum, C. histolyticum) was demonstrated on the experimental model of wound infection (gas gangrene) of guinea pigs. The schedule of rapid immunization with tetratoxoid was developed, which made it possible to create good immunological preparedness (basic immunity) for subsequent revaccination in case of traumas within 6 days. The effectiveness of rapid immunization by the application of tetratoxoid on the wound was shown. This immunization ensured a considered increase in the titers of antitoxins within the first 6 days, which increased the protection of the animals from infection with each of the four causative agents of gas gangrene.
Sergeeva
T I
TI
Chirikova
E V
EV
Babaĭtseva
V A
VA
D000818:Animals; D000992:Antitoxins / Q000097:blood; D003013:Clostridium / Q000276:immunology*; D003016:Clostridium perfringens / Q000276:immunology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004630:Emergencies; D005738:Gas Gangrene / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D006168:Guinea Pigs; D007117:Immunization, Secondary; D051379:Mice; D011817:Rabbits; D013997:Time Factors; D014121:Toxoids / Q000627:therapeutic use*; D014946:Wound Infection / Q000276:immunology / Q000401:mortality / Q000517:prevention & control
D000992:Antitoxins; D014121:Toxoids
Eksperimental'noe obosnovanie metodov ékstrennoĭ immunoprofilaktiki gazovoĭ gangreny.