Short echo time proton spectroscopy of the brain in HIV infection/AIDS.
Short echo time proton spectra have been acquired from the brains of 30 male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and 12 age-matched control subjects on a 1.5 T MR system. The acquisition protocol used stimulated acquisition voxel localisation with a voxel size of 8 ml and repeat, echo, and mixing times of 5000, 20, and 30 ms, respectively. A single 25.6-ms Gaussian water suppression pulse was used with 128 spectral acquisitions and the data were eddy current corrected using a water reference. Baseline-corrected spectra were nonlinearly least squares fitted to a model function consisting of Gaussian functions representing the major metabolites reported in short echo proton spectra. Results indicate that the N-acetyl/creatine (NA/Cr) ratio is significantly reduced by 20% in AIDS patients [NA/Cr = 1.91 (0.51)] compared to control subjects [NA/Cr = 2.37 (0.25)] at short echo times.
Paley
M
M
MRI Unit, Middlesex Hospital, University College London Hospitals, UK.
Wilkinson
I D
ID
Hall-Craggs
M A
MA
Chong
W K
WK
Chinn
R J
RJ
Harrison
M J
MJ
D015526:AIDS Dementia Complex / Q000378:metabolism*; D000328:Adult; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male