[Sjögren's syndrome associated with non-Hodgkin's lymphoma].
Sjögren's syndrome (SS) is characterized by an increased risk of development of a non-Hodgkin's lymphoma (NHL). In this paper, the clinical, histological and molecular biological topics, with a brief account of two cases of NHL, in SS are discussed. Low grade NHL, typically monocytoid B cell lymphoma related to mucosa associated lymphoid tissue (MALT) lymphoma, is the topic of NHL in SS. B cell clonal expansion has been detected by DNA analysis of immunoglobulin gene in non-lymphoma patients, as well as, in NHL patients in SS. Molecular biological analysis, especially detection of fusion gene of IgH and bcl-2, t(14;18), using PCR method, can help to detect early onset of NHL in SS. A better understanding of NHL in SS is needed to develop a co-operative research of large mass study.
Department of Internal Medicine, Niigata prefectural Central Hospital.
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Nagai
D000368:Aged; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2; D012859:Sjogren's Syndrome / Q000150:complications*
D007136:Immunoglobulins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2