Influence of age, treadmill running, and food restriction on plasma fibrinogen concentration and expression of gamma chain mRNA in female Sprague-Dawley rats.
Plasma fibrinogen concentration and expression of mRNA encoding the gamma-chain of fibrinogen were determined in female Sprague-Dawley rats aged 10, 21 and 30 months. Both parameters increased significantly with age in a parallel fashion. Food restriction was able to reduce the age-dependent increase of both plasma concentration and gene expression to levels below young controls. On the other hand, long-term treadmill running failed to influence the plasma fibrinogen concentration. From these results we conclude that the plasma fibrinogen concentration increases with age due to an increased fibrinogen biosynthesis.
Dorner
H
H
Chair of Internal Medicine-Gerontology, University of Erlangen-Nürnberg, Germany.
Fischer
B
B
Seefried
G
G
Platt
D
D
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D004586:Electrophoresis; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis*; D005508:Food Deprivation / Q000502:physiology*; D008099:Liver / Q000473:pathology; D009043:Motor Activity / Q000502:physiology*; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D012333:RNA, Messenger; D005340:Fibrinogen