Distinct Xp11.2 breakpoints in two renal cell carcinomas exhibiting X;autosome translocations.
Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X;1)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above-mentioned subset of RCC. Using FISH in conjunction with X-specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2.
Dijkhuizen
T
T
Department of Medical Genetics, University of Groningen, The Netherlands.
van den Berg
E
E
Wilbrink
M
M
Weterman
M
M
Geurts van Kessel
A
A
Störkel
S
S
Folkers
R P
RP
Braam
A
A
de Jong
B
B
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002871:Chromosome Banding; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014960:X Chromosome