Hypertension as a factor in chronic renal insufficiency progression in polycystic kidney disease. The Northern Italian Cooperative Study Group.
The aim of this study was to evaluate the role of blood pressure in the progression of chronic renal failure (CRF) in polycystic kidney disease, by analysing the behaviour of 74 affected patients, out of 456 CRF patients with various underlying nephropathies enrolled in a multicentre, formal prospective trial aimed at clarifying the role of protein restriction in retarding CRF progression. Because no difference was found between the patients on a low protein and those on a controlled protein diet, an inductive analysis was made by separating all of the patients into fast progressive or slowly progressive CRF groups. Hypertensive patients were defined as those with a mean resting blood pressure of more than 107 mmHg; of the 62 polycystic patients who completed the study or who reached an end point, 41 patients were hypertensive and 21 normotensive (10 of whom were pharmacologically controlled). The results of the stratified analysis, taking into account the degree of renal function deterioration and the underlying disease, showed a significant relationship between hypertension and CRF progression only in patients with polycystic kidney disease.
Marcelli
D
D
Divisione di Nefrologia e Dialisi, Azienda Ospedaliera di Lecco, Italy.
Locatelli
F
F
Alberti
D
D
Graziani
G
G
Buccianti
G
G
Redaelli
B
B
Giangrande
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D018753:Diet, Protein-Restricted; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000150:complications* / Q000178:diet therapy / Q000209:etiology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors