Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor.
We report a patient with eosinophilia accompanied by Hodgkin's disease who showed remarkable increase in granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma but no increase in interleukin-5 (IL-5). The plasma GM-CSF level normalized as eosinophilia and lymphadenopathy disappeared after chemotherapy. Immunohistochemical study with immunoperoxidase staining technique showed a positive stain in lymph node cells by monoclonal anti-GM-CSF antibody. Eosinophilia is often accompanied by Hodgkin's disease, and several cases have been reported to show high levels of plasma IL-5. To our knowledge, this is the first report to show a high level of plasma GM-CSF in Hodgkin's disease with eosinophilia.
Endo
M
M
Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan.
Usuki
K
K
Kitazume
K
K
Iwabe
K
K
Okuyama
Y
Y
Urabe
A
A
D000368:Aged; D004802:Eosinophilia / Q000503:physiopathology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000032:analysis*; D006689:Hodgkin Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008297:Male
D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor