Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021.
Renal damage in rat hemorrhagic shock model was assessed by estimation of the reactive oxygen metabolites generation (malondialdehyde measured as thiobarbituric acid reactive substances) and antioxidative potential (activity of Cu-, Zn- superoxide dismutase, activity of glutathione reductase and level of sulfhydryl compounds). It was found that treatment with BN 52021 (a platelet-activating factor antagonist), and polyelektrolyte solution had had a beneficial effect in comparison with both the untreated shock and shock treated by reperfusion only.
Department of Pediatric Surgery, Medical Academy of Bialystok.
J K
JK
Kirejczyk
W
W
Debek
J
J
Dziecioł
L
L
Chyczewski
M
M
Makarewicz
J
J
Nikliński
D000704:Analysis of Variance; D000818:Animals; D004224:Diterpenes; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D046934:Ginkgolides; D005980:Glutathione Reductase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007783:Lactones / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D004224:Diterpenes; D005609:Free Radicals; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D013438:Sulfhydryl Compounds; C039351:platelet activating factor receptor; C045856:ginkgolide B; D013482:Superoxide Dismutase; D005980:Glutathione Reductase