Measles virus replication in neural cells.
Measles virus gene expression is attenuated in neural cells by mechanisms that affect both viral transcription and translation. Host enzymes that hypermutate viral genes, and those induced by cytokines, may act cooperatively to slow viral replication and to favor persistent measles virus infections in the human central nervous system.
Institute for Virology, Würzburg, Germany
I C
IC
Johnston
L M
LM
Dunster
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J
Schneider-Schaulies
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S
Schneider-Schaulies
D001921:Brain / Q000166:cytology / Q000821:virology*; D016207:Cytokines / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D008459:Measles virus / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009474:Neurons / Q000821:virology*; D014158:Transcription, Genetic; D014779:Virus Replication / Q000235:genetics
D016207:Cytokines