Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose.
Drug-induced eosinophilic lung disease commonly presents as a simple pulmonary eosinophilia-like syndrome consisting of transient pulmonary infiltrates, peripheral eosinophilia, and mild pulmonary symptoms that disappear promptly upon withdrawal of the offending medication. However, a more fulminant presentation most resembling acute eosinophilic pneumonia has been recently described. We present a patient with BAL-confirmed eosinophilic pneumonia (EP) and respiratory failure after a trazodone overdose. This is the first case of EP associated with trazodone and only the third drug-mediated EP reported to precipitate respiratory failure.
Department of Medicine, Madigan Army Medical Center, Tacoma, Washington 98431-5000, USA.
S M
SM
Salerno
J S
JS
Strong
B J
BJ
Roth
V
V
Sakata
D000208:Acute Disease; D000328:Adult; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D014196:Trazodone / Q000506:poisoning*
D014196:Trazodone