[Refractory epilepsy in adults and the new antiepileptic drugs: the role of gabapentin].
The features of refractory epilepsies and the role of functional surgery and new antiepileptic drugs is reviewed. Among the latter, gabapentin, a drug with peculiar pharmacokinetic properties, is highlighted as a therapeutic alternative in refractory epilepsies and eventually for epileptic patients without previous treatment. A new type of relationship between the pharmaceutical industry and physicians, that privileges clinical research, is discussed.
Departamento de Neurología Neurocirugía, Facultad de Medicina, Universidad de Chile, Hospital Clínico José Joaquín Aguirre, Santiago de Chile.
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D
Galdames
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L
Aguilera
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Fauré
D000085:Acetates / Q000097:blood / Q000627:therapeutic use*; D000588:Amines; D000927:Anticonvulsants / Q000627:therapeutic use*; D002677:Chile; D002986:Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy* / Q000601:surgery; D000077206:Gabapentin; D006801:Humans; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
La epilepsia refractaria del adulto y los antiepilépticos noveles: el rol de la gabapentina.