[Anticardiolipin antibodies, cerebral ischemia and adrenal hemorrhage in a newborn infant].
BACKGROUND
Anticardiolipin antibodies, usually associated with vascular thrombosis in systemic lupus erythematosus, have been recently found associated with strokes in childhood, and acute adrenal hemorrhage in the adult.


METHODS
A 3 day-old fullterm newborn suffering from cerebrovascular ischemia and bilateral massive hemorrhage was found to have anticardiolipin antibodies detected during the neonatal period and 7 months later. There was no evidence of pathology in the mother or perinatal asphyxia. However, anticardiolipin antibodies were present in the mother 5 and 15 weeks after delivery.


CONCLUSIONS
Association of anticardiolipin antibodies and vascular thrombosis has never been reported in the neonate. Persistence of such antibodies favor the hypothesis that they are not transmitted by the mother; they could represent an early manifestation of primary antiphospholipid syndrome.
Service de réanimation pédiatrique, hôpital Nord, Saint-Etienne, France.
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G
Teyssier
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V
Gautheron
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L
Absi
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Galambrun
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Ravni
J C
JC
Lepetit
D000307:Adrenal Gland Diseases / Q000150:complications* / Q000276:immunology; D017153:Antibodies, Anticardiolipin / Q000276:immunology*; D002545:Brain Ischemia / Q000150:complications* / Q000276:immunology; D006470:Hemorrhage / Q000150:complications* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D017153:Antibodies, Anticardiolipin
Anticorps anticardiolipine, ischémie cérébrale et hémorragie surrénalienne chez un nouveau-né.