Danger of amiodarone therapy and elevated inspired oxygen concentrations in mice.
Our study showed a statistically significant incidence of pulmonary edema in mice receiving amiodarone and 100% oxygen. This finding, together with a variety of clinical reports, indicates that in patients receiving amiodarone therapy, FiO2 should be maintained at the lowest possible level, consistent with adequate oxygenation.
Department of Anesthesiology, Baylor University Medical Center, Dallas, Texas 75246, USA.
S K
SK
Donica
A W
AW
Paulsen
B R
BR
Simpson
M A
MA
Ramsay
C T
CT
Saunders
T H
TH
Swygert
J
J
Tappe
D000638:Amiodarone / Q000009:adverse effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D008168:Lung / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000378:metabolism*; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000378:metabolism; D012119:Respiration; D014665:Vasodilator Agents / Q000009:adverse effects*
D000889:Anti-Arrhythmia Agents; D014665:Vasodilator Agents; D000638:Amiodarone; D010100:Oxygen