[Scintigraphy of iodine 123 labelled serum amyloid P component in beta 2-microglobulin amyloidosis of hemodialysis].
To assess the iodine-123-labelled serum amyloid P component (SAP) scintigraphy in patients with haemodialysis-associated amyloidosis.


METHODS
Eight patients with histologically proven beta 2-microglobulin amyloidosis.


METHODS
Purified SAP was iodinated by a modified iodogen method. Whole body data were acquired with a large rectangular field gamma-camera.


RESULTS
In 7 cases, articular uptake was observed in the symptomatic joints (shoulders, wrists, knees) or in view of bone cysts (wrists). Among the 3 patients with erosive arthropathy of the hands, only one had positive scintigraphy. None positive scintigraphic image was obtained in the spine or the hip joint. In one patient with multifocal amyloid joint disease, no positive image was noted. No abnormal visceral uptake was observed and particularly of the spleen except in one patient with liver uptake.


CONCLUSIONS
I-123 SAP scintigraphy might be not very sensitive in diagnosing beta 2 amyloid deposits. This method needs further investigations and particularly in patients undergoing haemodialysis for more than 20 years.
Service de rhumatologie (Pr B. Delcambre), Höpital B. CHRU Lille.
R M
RM
Flipo
M
M
Deveaux
O
O
Duneton
P
P
Foissac-Gegoux
A
A
Dumont
B
B
Duquesnoy
X
X
Marchandise
D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D006435:Renal Dialysis / Q000009:adverse effects*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component; D001613:beta 2-Microglobulin
Etude de la scintigraphie au composant sŕique amyloïde P marqué à l'iode 123 dans l'amylose à bêta 2-microglobuline des hémodialysés.