[Comparative study of nicardipine versus placebo in the prevention of cognitive deterioration in patients with transient ischemic attack].
The neuropsychological follow up of transient ischemic attacks can provide a model for evaluating the efficiency of a drug in vascular dementia. A double blind study has been conducted using nicardipine, a calcium-antagonist, as opposed to a placebo in 40 patients with transient ischemic attacks, over a six month period. The patients were evaluated according to a Wechsler's intelligence scale, and their memory was also tested before and after this period. Although no alterations were registered on either scale, some differences did appear in certain sub-tests, especially as regards the verbal coefficient. This pilot study has provided information concerning the possible beneficial effect of the drug, which should be proven by means of a larger-scale study.
Hospital Virgen de los Lirios de Alcoy, Departamento de Medicina, Universidad de Alicante.
J M
JM
Moltó
R
R
Falip
R
R
Martín
R
R
Insa
I
I
Pastor
J
J
Matías-Guiu
D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D016896:Treatment Outcome; D014888:Wechsler Scales
D002121:Calcium Channel Blockers; D010919:Placebos; D009529:Nicardipine
Estudio comparativo de nicardipina frente a placebo en la prevención del deterioro cognitivo en los pacientes con accidentes isquémicos transitorios.