A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk.
The associations between lung cancer risk, mutagen sensitivity (a marker of cancer susceptibility), and a putative lung carcinogen, wood dust, were assessed in a hospital-based case-control study. There were 113 African -American and 67 Mexican-American cases with newly diagnosed, previously untreated lung cancer and 270 controls, frequency-matched on age, ethnicity, and sex. Mutagen sensitivity ( 1 chromatid break/cell after short-term bleomycin treatment) was associated with statistically significant elevated risk for lung cancer [odds ration (OR) = 4.3; 95% confidence intervals (CI) = 2.3-7.9]. Wood dust exposure was also a significant predictor of risk (overall OR = 3.5; CI = 1.4-8.6) after controlling for smoking and mutagen sensitivity. When stratified by ethnicity, wood dust exposure was s significant risk factor for African-Americans (OR = 5.5; CI = 1.6-18.9) but not for Mexican-Americans (OR = 2.0; CI = 0.5-8.1). The ORs were 3.8 and 4.8 for non-small cell lung cancer in Mexican-Americans (CI = 1.2-18.5). Stratified analysis suggested evidence of strong interactions between wood dust exposure and both mutagen sensitivity and smoking in lung cancer risk.
Department of epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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Wu
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Delclos
J F
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Annegers
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Bondy
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Honn
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Henry
T C
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Hsu
M R
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Spitz
D000328:Adult; D017677:Age Distribution; D000368:Aged; D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D016001:Confidence Intervals; D004391:Dust / Q000009:adverse effects*; D005260:Female; D016468:Forestry; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D008297:Male; D017058:Mexican Americans / Q000235:genetics / Q000706:statistics & numerical data; D008875:Middle Aged; D009152:Mutagenicity Tests; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D018570:Risk Assessment; D017678:Sex Distribution; D012907:Smoking; D013781:Texas / Q000453:epidemiology; D014934:Wood; D001741:Black or African American
D004391:Dust