The expression of mRNA for fibrinogen in megakaryocytes isolated from patients with T-cell lymphoma.
The expression of fibrinogen mRNA was studied by in situ hybridization in freshly isolated megakaryocytes in 14 newly-diagnosed patients: seven with non-Hodgkin's lymphoma (NHL), three with immune thrombocytopenic purpura (ITP) and four haematologically normal patients prior to coronary artery bypass surgery. Fibrinogen mRNA in megakaryocytes was not detected in ITP, B-cell lymphomas or in healthy donors. However, it was present in all patients with the high-grade T-cell lymphomas, both with and without thrombocytopenia.
Podolak-Dawidziak
M
M
Department of Haematology, Medical University, Wroclaw, Poland.
Hancock
V
V
Lelchuk
R
R
Kotlarek-Haus
S
S
Martin
J F
JF
D000328:Adult; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D008297:Male; D008533:Megakaryocytes / Q000378:metabolism*; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism*
D012333:RNA, Messenger; D005340:Fibrinogen