Myelin- and microbe-specific antibodies in Guillain-Barré syndrome.
We surveyed the frequency of reported infections and target autoantigens in 56 Guillain Barré syndrome (GBS) patients by detecting antibodies to myelin and microbes. Sulfatide (43%), cardiolipin (48%), GD1a (15%), SGPG (11%), and GM3 (11%) antibodies were the most frequently detected heterogenous autoantibodies. A wide spectrum of antimicrobial IgG and IgM antibodies were also detected; mumps-specific IgG (66%), adenovirus-specific IgG (52%), varicella-zoster virus-specific IgG (46%), and S. pneumoniae serotype 7-specific IgG (45%) were the most prevalent. Our results indicate that polyclonal expansion of physiologic and pathologic antibodies and/or molecular mimicry likely occurs following infection and is related to other autoimmune factors in the etiology of GBS. Although no single definitive myelin-specific autoantibody was identified, our results suggest a unique pattern of reactivity against autoantigens.
Terryberry
J
J
Specialty Laboratories, Santa Monica, CA 90404-3900, USA.
Sutjita
M
M
Shoenfeld
Y
Y
Gilburd
B
B
Tanne
D
D
Lorber
M
M
Alosachie
I
I
Barka
N
N
Lin
H C
HC
Youinou
P
P
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood* / Q000134:cerebrospinal fluid; D000914:Antibodies, Viral / Q000097:blood* / Q000134:cerebrospinal fluid; D000918:Antibody Specificity; D001324:Autoantigens / Q000276:immunology; D002648:Child; D002855:Chromatography, Thin Layer; D003429:Cross Reactions; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D012044:Regression Analysis
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001324:Autoantigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009185:Myelin Proteins