Laue crystallography. It's show time.
New crystallographic techniques make it possible to observe directly all of the intermediates in an enzymatic reaction. Such a series of structures can be combined to create a detailed movie of enzymatic catalysis.
Farber
G K
GK
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA.
D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray / Q000379:methods*; D007521:Isocitrate Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D015394:Molecular Structure; D016297:Mutagenesis, Site-Directed; D013329:Structure-Activity Relationship
D007521:Isocitrate Dehydrogenase