[Effect of reimplantation response on recipient pulmonary hemodynamics in single lung transplantation].
Until now, reimplantation response (RR) has been thought to be a transient dysfunction of the transplanted lung in single lung transplantation. How does RR influence on the native lung in single lung transplantation? We studied the influence of RR to the native lung with 20 dogs which were divided separated into 3 groups. In group I (6 dogs) and II (6), left lung allotransplantation without immunosuppression was performed. In group II, PGI2 was administered to the donors at 1 microgram/kg/min for 60 minutes iv drip infusion during lung extraction and super oxide dismutase (SOD) was administered to the recipients at 20 mg/kg just before reperfusion of the transplanted lung. In group III (8), allotransplantation with immunosuppression (CYA 20 mg/kg, AZ 4 mg/kg) was done using PGI2 and SOD in the same way as group II. In all groups doppler flow probes were attached to the ascending aorta and left pulmonary artery. For over 1 week, pulmonary hemodynamics was evaluated. In group I pulmonary arterial pressure increased up to 38.7 +/- 19.7 mmHg on 3 postoperative day, which showed significant difference (p < 0.05) from group II. An increase in vascular resistance of the transplanted lung was recognized right after transplantation in the both groups (0.212 +/- 0.058 mmHg/ml/kg to 0.487 +/- 0.114 in group I, 0.207 +/- 0.072 to 0.407 +/- 0.172 in group II). However, vascular resistance of the right lung increased in group I against group II right after transplantation (0.182 +/- 0.116 to 0.367 +/- 0.195 in group I, 0.183 +/- 0.116 to 0.214 +/- 0.149 in group II), which showed significant difference (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Surgery, Kobe University School of Medicine, Japan.
H
H
Yamamoto
C
C
Yamashita
M
M
Okada
S
S
Tobe
F
F
Tsuji
H
H
Ohbo
H
H
Nakamura
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology; D008168:Lung / Q000502:physiology* / Q000601:surgery*; D011652:Pulmonary Circulation / Q000502:physiology; D015427:Reperfusion Injury / Q000517:prevention & control; D012092:Replantation; D013482:Superoxide Dismutase / Q000494:pharmacology; D014184:Transplantation, Homologous; D014655:Vascular Resistance / Q000502:physiology
D011464:Epoprostenol; D013482:Superoxide Dismutase