Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura.
Migraine is a common neurological disease of two main types: migraine with aura and migraine without aura. Familial clustering suggests that genetic factors are involved in the etiology of migraine. Recently, a gene for familial hemiplegic migraine, a rare autosomal dominant subtype of migraine with aura, was mapped to chromosome 19p13. We tested the involvement of this chromosomal region in 28 unrelated families with the common forms of migraine with and without aura, by following the transmission of the highly informative marker D19S394. Sib-pair analysis showed that affected sibs shared the same marker allele more frequently than expected by chance. Our findings thus also suggest the involvement of a gene on 19p13 in the etiology of the common forms of migraine.
Department of Neurology, Essen University, Germany.
A
A
May
R A
RA
Ophoff
G M
GM
Terwindt
C
C
Urban
R
R
van Eijk
J
J
Haan
H C
HC
Diener
D
D
Lindhout
R R
RR
Frants
L A
LA
Sandkuijl
D001483:Base Sequence; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D008881:Migraine Disorders / Q000235:genetics* / Q000503:physiopathology; D008969:Molecular Sequence Data; D010375:Pedigree