A slow acetylator genotype is a risk factor for sulphonamide-induced toxic epidermal necrolysis and Stevens-Johnson syndrome.
Department of Dermatology, Hôpital Henri-Mondor, Créteil, France.
P
P
Wolkenstein
V
V
Carrière
D
D
Charue
S
S
Bastuji-Garin
J
J
Revuz
J C
JC
Roujeau
P
P
Beaune
M
M
Bagot
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000009:adverse effects*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000453:epidemiology* / Q000235:genetics; D013449:Sulfonamides / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000927:Anticonvulsants; D013449:Sulfonamides; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D001191:Arylamine N-Acetyltransferase