Inhibition of Ras function in vitro and in vivo using inhibitors of farnesyl-protein transferase.
Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
N E
NE
Kohl
F R
FR
Wilson
T J
TJ
Thomas
R L
RL
Bock
S D
SD
Mosser
A
A
Oliff
J B
JB
Gibbs
D016475:3T3 Cells; D019883:Alkyl and Aryl Transferases; D000818:Animals; D002460:Cell Line; D004151:Dipeptides / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D017368:Protein Prenylation / Q000187:drug effects; D051381:Rats; D014166:Transferases / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000037:antagonists & inhibitors*
D004151:Dipeptides; D004791:Enzyme Inhibitors; C081840:L 731734; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D018631:ras Proteins