Stimulation and regulation of tumor cell motility in invasion and metastasis.
In this review, the role of extracellular factors in the stimulation and regulation of tumor cell motility are discussed. Tumor cells respond in a motile fashion to a variety of external ligands including autocrine motility factors, growth factors, and components of the extracellular matrix. Since tumor cell motility is a necessary component of tumor invasion and metastasis, we speculate that these protein factors could play important regulatory roles in tumor motility at different stages of the metastatic cascade.
Levine
M D
MD
Harvard College, Cambridge, MA 02138, USA.
Liotta
L A
LA
Stracke
M L
ML
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002465:Cell Movement; D002630:Chemotactic Factors / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D005956:Glucose-6-Phosphate Isomerase / Q000737:chemistry / Q000502:physiology*; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000503:physiopathology; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured; D000099189:Lysophospholipase D
D002630:Chemotactic Factors; D016207:Cytokines; D005956:Glucose-6-Phosphate Isomerase; D006023:Glycoproteins; D006133:Growth Substances; D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D000099189:Lysophospholipase D