Identification of new members of a carbohydrate kinase-encoding gene family.
In a sequence database search using the human glycerol kinase-encoding sequence (HUMGLYKINB) as a query, we identified six previously unidentified carbohydrate kinase sequences. Five of the six newly identified sequences appear to be known types of carbohydrate kinases, four are glycerol kinases and one is a gluconokinase. The sixth newly identified sequence, the Caenorhabditis elegans gene, CER08D7.7-CEF59B2.1, shows similarity to the family of carbohydrate kinases including other glycerol kinases, xylulokinases, gluconokinases, ribulokinases, rhamnulokinases, and fucokinases. A phylogenetic comparison of this newly identified Caenorhabditis elegans gene with the other members of the carbohydrate kinase family demonstrated that this sequence cannot be assigned to one of the known classes of carbohydrate kinases.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
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Worley
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King
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Chua
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McCabe
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Smith
D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000235:genetics; D002241:Carbohydrates; D017124:Conserved Sequence; D016208:Databases, Factual; D017238:Genes, Helminth; D005941:Glucokinase / Q000235:genetics; D005991:Glycerol Kinase / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software
D002241:Carbohydrates; D017853:Phosphotransferases (Alcohol Group Acceptor); D005941:Glucokinase; D005991:Glycerol Kinase