Sequence and analysis of the rpoB gene of Mycobacterium smegmatis.
The rpoB gene encodes the beta subunit of the DNA-dependent RNA polymerase of bacteria. Mutations in defined areas result in resistance to rifampin. Mycobacterium smegmatis is naturally resistant to rifampin, but analysis of the rpoB gene revealed no identifiable rifampin resistance mutations. Another mechanism of resistance may be present.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
S V
SV
Hetherington
A S
AS
Watson
C C
CC
Patrick
D000595:Amino Acid Sequence; D000995:Antitubercular Agents / Q000494:pharmacology; D003001:Cloning, Molecular; D004259:DNA-Directed DNA Polymerase / Q000235:genetics* / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D005798:Genes, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000187:drug effects* / Q000235:genetics*; D012293:Rifampin / Q000494:pharmacology
D000995:Antitubercular Agents; D004259:DNA-Directed DNA Polymerase; D012293:Rifampin