Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis.
During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur in global regulators, such as alternative sigma factors and their accessory elements.
Deretic
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Dept of Microbiology, University of Texas Health Science Center at San Antonio 78284-7758, USA.
Schurr
M J
MJ
Yu
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D016667:Bacterial Capsules / Q000096:biosynthesis*; D001483:Base Sequence; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications*; D005798:Genes, Bacterial / Q000502:physiology*; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000382:microbiology*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D011552:Pseudomonas Infections / Q000150:complications / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity / Q000502:physiology*; D014169:Transformation, Bacterial / Q000235:genetics