Redirection of cellular cytotoxicity. A two-step approach using recombinant single-chain Fv molecules.
In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a "universal" bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.
George
A J
AJ
Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Titus
J A
JA
Jost
C R
CR
Kurucz
I
I
Perez
P
P
Andrew
S M
SM
Nicholls
P J
PJ
Huston
J S
JS
Segal
D M
DM
D018033:Antibodies, Bispecific / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D016259:Genes, myc; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018033:Antibodies, Bispecific; D007135:Immunoglobulin Variable Region; D011993:Recombinant Fusion Proteins