Local anesthetic [2-(decyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid perturbs phosphatidylcholine bilayer.
Monohydrochloride of [2-(decyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid (C10A) has a biphasic effect on the fluidity of egg yolk phosphatidylcholine (EYPC) model membranes as detected by the methyl ester of stearic acid spin probe, with the paramagnetic doxyl group bound to C-16. The fluidity increases up to a molar ratio of C10A:EYPC = 0.5 with a subsequent decrease. This decrease in fluidity may be due to interdigitation of hydrocarbon chains in the bilayer.
Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
J
J
Gallová
J
J
Cizmárik
P
P
Balgavý
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity / Q000187:drug effects*; D048448:Phenylcarbamates; D010713:Phosphatidylcholines / Q000737:chemistry*; D010880:Piperidines / Q000494:pharmacology*; D013113:Spin Labels
D000779:Anesthetics, Local; D002219:Carbamates; D003497:Cyclic N-Oxides; D008051:Lipid Bilayers; D048448:Phenylcarbamates; D010713:Phosphatidylcholines; D010880:Piperidines; D013113:Spin Labels; C032363:16-nitroxystearic acid; C097380:2-(1-piperidinyl)ethyl 2-(decyloxy)phenylcarbamate