Apolipoprotein E epsilon 4 in inclusion body myositis.
The genetic predisposition to inclusion body myositis (IBM) is probably multifactorial. The deposition of the beta-amyloid protein is a characteristic histological feature of both IBM and Alzheimer's disease (AD). The epsilon 4 allele of apolipoprotein E (APO E) has been strongly associated with familial and late-onset AD. We therefore compared the APO E allele frequencies in a group of 14 patients with IBM with those in a group of patients with other inflammatory muscle diseases and in the general population. The frequency of the epsilon 4 allele in IBM was increased (0.29) compared with that in patients with other inflammatory muscle diseases (0.15) and the general population (0.13) (p < 0.05). These data suggest that APO E genotype may be one of the factors involved in determining the predisposition to the development of IBM.
Australian Neuromuscular Research Institute, Australia.
M J
MJ
Garlepp
H
H
Tabarias
F M
FM
van Bockxmeer
P J
PJ
Zilko
B
B
Laing
F L
FL
Mastaglia
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000235:genetics*; D017678:Sex Distribution
D001057:Apolipoproteins E