Oral ciprofloxacin as prophylaxis in gastroduodenal surgery.
One hundred and fifty patients undergoing gastroduodenal surgery were randomly allocated to receive intravenous (iv) cefuroxime, iv ciprofloxacin or oral ciprofloxacin as prophylaxis. There were no differences in the incidence of postoperative infection complications or duration of stay among the three groups. Oral ciprofloxacin offers obvious advantages in terms of ease of administration and cost.
McArdle
C S
CS
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Morran
C G
CG
Anderson
J R
JR
Pettit
L
L
Gemmell
C G
CG
Sleigh
J D
JD
Tillotson
G S
GS
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000517:prevention & control*; D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004386:Duodenum / Q000601:surgery*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012606:Scotland; D013270:Stomach / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D002444:Cefuroxime