Successful matched unrelated transplantation from a donor with idiopathic thrombocytopenic purpura (ITP).
The case of a 5 year old male is described who had acute myeloblastic leukaemia (AML M5) and was in third remission when he underwent an allogeneic T cell depleted bone marrow transplantation (BMT). The bone marrow was from an HLA matched unrelated donor (MUD) who suffered from chronic idiopathic thrombocytopenic purpura (ITP). In spite of this, the patient had rapid platelet engraftment post BMT (> 50 x 10(9) l-1 on day 20). He is now 12 months post-transplantation and has normal platelet counts, without any clinical or laboratory evidence of ITP. Autoimmune manifestations such as ITP occurring in bone marrow recipients following BMT have been previously reported. Furthermore, severe and protracted thrombocytopenia is a known complication following MUD transplantation and with its respective high risk of graft versus host disease (GVHD). In this case, no signs of ITP could be detected in the recipient despite the fact that the donor had ITP. Our data suggest that in the absence of an alternative choice, a person with ITP should be considered as an appropriate donor for transplantation.
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
M
M
Delukina
Y
Y
Kapelushnik
R
R
Or
E
E
Naparstek
S
S
Slavin
A
A
Nagler
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000628:therapy*; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014019:Tissue Donors