The association between oral leukoplakia and use of tobacco, alcohol and khat based on relative risks assessment in Kenya.
A case-control study was conducted to determine the significance of tobacco, alcohol and khat (Catha edulis) chewing habits in the development of oral leukoplakia among Kenyans aged 15 yr and over. In a house-to-house survey, 85 cases and 141 controls matched for sex, age and cluster origin was identified and compared for these risk factors. Smoking unprocessed tobacco (Kiraiku) with a relative risk (RR) of 10.0 (95% confidence interval (CI) = 2.9-38.4) and smoking cigarettes (RR = 8.4; 95% CI = 4.1-17.4) were the most significant factors. While the RR associated with smoking cigarettes alone was 4.5 (95% CI = 1.9-10.8), smoking of both products (RR = 15.2) suggested probable synergy or additive effects. Oral leukoplakia in 18 cases could not be attributed to smoking tobacco. Commercial beer, wines and spirits were relatively weak, but statistically significant, risk factors. Traditional beer, khat and chilies were not significantly associated with oral leukoplakia.
University of Nairobi, College of Health Sciences, Department of Dental Surgery, Kenya.
F G
FG
Macigo
D L
DL
Mwaniki
S W
SW
Guthua
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D029754:Catha; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D007972:Leukoplakia, Oral / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects*; D010947:Plants, Toxic; D018570:Risk Assessment; D012744:Sex Ratio; D012907:Smoking / Q000009:adverse effects*; D014026:Nicotiana
D010936:Plant Extracts