Spontaneous recovery or evoked reversal of neuromuscular block.
Recovery from the effects of muscle relaxants can occur either spontaneously by their metabolism in the body or by elimination via the normal excretion pathways, or by the administration of pharmacologic antagonists. The decision as to whether spontaneous recovery should be allowed to take place or pharmacologic reversal should be induced depends upon several factors, principal among them being the duration of action of the muscle relaxant used, its dose, and the time that is available. The recovery times of most relaxants, including atracurium and vecuronium, are such as to require antagonism if adequate recovery is to be attained quickly. An agent such as mivacurium may, however, allow complete spontaneous recovery to take place without the use of antagonists.
Department of Anaesthetics, Royal Victoria Hospital, Belfast, UK.
R K
RK
Mirakhur
D000762:Anesthesia Recovery Period; D001279:Atracurium / Q000037:antagonists & inhibitors / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D004491:Edrophonium / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007546:Isoquinolines / Q000037:antagonists & inhibitors / Q000378:metabolism; D000077590:Mivacurium; D009388:Neostigmine / Q000008:administration & dosage / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011729:Pyridostigmine Bromide / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014673:Vecuronium Bromide / Q000037:antagonists & inhibitors / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D009388:Neostigmine; D004491:Edrophonium; D000077590:Mivacurium; D014673:Vecuronium Bromide; D011729:Pyridostigmine Bromide