Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461.
Dugar
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Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA.
Clader
J W
JW
Chan
T M
TM
Davis
H
H
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006224:Cricetinae; D015195:Drug Design; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000924:Anticholesteremic Agents; D001384:Azetidines; C095487:1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone