[Circulating antigliadin antibodies. Prevalence in a diabetic (type 1 or 2) and non diabetic adult population].
OBJECTIVE
The level of circulating antigliadin antibodies is an essential element in diabetic patients with signs of coeliac disease. Intolerance to gluten can disrupt glucose regulation leading to greater risk of hypoglycaemia. Search for antigliadin antibodies could be a routine test in diabetics.


METHODS
Plasma gliadin antibodies were measured by immunoenzymatic assay in adult subjects: 80 type 1 diabetics, 80 type 2 diabetics, 80 non diabetics without auto-immune disease.


RESULTS
IgA antibodies were present in 6 type 1 diabetics (7.5%), 8 type 2 diabetics (10%) and 6 non-diabetics (7.5%). Anti-reticulin and anti-endomysium antibodies were measured in type 1 diabetics with antigliadine antibodies. They were present only in one patient (Tunisian) who suffered from a coeliac disease.


CONCLUSIONS
In France, the prevalence of coeliac disease is very low. Antigliadin antibodies measurement is justified only in patients with clinical and/or biological symptoms of coeliac disease.
Tourniaire
J
J
Clinique Endocrinologique, Hôpital de l'Antiquaille, Lyon.
Guichard-Rode
S
S
Monier
J C
JC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D000906:Antibodies; D005903:Gliadin
Anticorps anti-gliadine circulants. Prévalence dans une population adulte diabétique (de type 1 ou 2) et non diabétique.