Nutritional status and growth hormone-binding protein.
To study the effects of nutrition on growth hormone (GH) receptor status, the plasma GH-binding protein was evaluated under conditions of poor nutrition, anorexia nervosa, celiac disease, and obesity. Nine patients, aged 12-30 years, presented anorexia nervosa and had a mean weight loss of -19% of their initial weight at the time of the study. Ten patients with celiac disease, aged 3-14 years, had a mean height at -4.2 SD, and normal body weight for height. Fourteen severely obese children, aged 3-10 years, had a mean body mass index (BMI) of 25.7 +/- 0.9. GH-binding protein was low in patients with anorexia nervosa (16.8 +/- 1.9% of radioactivity) and in patients with celiac disease (16.1 +/- 2.2%) whereas it was very high in obese children (57.2 +/- 3.3%). A strong correlation was found between GH-binding protein and BMI. GH-binding protein was also correlated with insulin-like growth factor-1 plasma levels. Nutrition is an important regulator of the GH receptor/binding protein. The growth failure presented by undernourished children is associated with partial GH resistance and low GH receptor level. On the contrary, children with obesity and normal growth have a high GH receptor level.
INSERM Unité 344, Faculté de Médecine Necker, Paris, France.
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Postel-Vinay
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Saab
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Gourmelen
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood / Q000503:physiopathology; D015992:Body Mass Index; D002352:Carrier Proteins / Q000378:metabolism*; D002446:Celiac Disease / Q000097:blood / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D009765:Obesity / Q000097:blood; D011863:Radioimmunoassay; D011986:Receptors, Somatotropin / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology
D002352:Carrier Proteins; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; C051815:somatotropin-binding protein