[Pre S1 antigen in different forms of hepatitis B virus infection].
Pre S1 antigen was measured using an ELISA technique in patients with different forms of hepatitis B virus infection. It was detected in 10 of 19 patients with acute hepatitis B (53%), 12 of 15 chronic hepatitis B virus carriers (80%), 9 of 11 patients with chronic hepatitis B (82%) and 3 of 4 patients with hepatoma and positive markers of hepatitis B virus infection. Pre S1 remained positive beyond 150 days in two patients with acute hepatitis that evolved to chronicity. Among subjects with chronic hepatitis B that received interferon, pre S1 antigen negativized only in the patient that had a complete response. Pre S1 detection is an index of hepatitis B virus replication and its persistence determines chronicity. Its negativization after antiviral therapy should have a predictive value.
Centro de Gastroenterología Hospital Clínico Universidad de Chile, Santiago de Chile.
J
J
Brahm
C
C
Hurtado
S
S
Elgueta
C
C
Fuentes
A
A
Velásquez
D000208:Acute Disease; D015415:Biomarkers; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D014779:Virus Replication
D015415:Biomarkers; D006511:Hepatitis B Antigens
Antígeno Pre S1 en diferentes formas de infección con el virus de la hepatitis B.