[The effect of gallopamil and propranolol in patients with ischemic cardiopathy and moderate depression of ventricular function].
BACKGROUND
Calcium channel blockers have been wide and successfully used in the treatment of coronary heart disease. Gallopamil, a metoxylic derivative of verapamil, has many of its properties and so, caution is recommended when given to patients with depressed left ventricular function. Clinical studies about this effect are scarce, and we have assessed it in patients with coronary heart disease and diminished left ventricular function.


METHODS
We studied 20 patients in a cross-over, randomized, double-blind study during three weeks active periods with two intercalating washout placebo periods of one week. Patients had history of previous myocardial infarction, positive exercise stress test and ejection fraction ranging from 30% to 50% by echocardiography.


RESULTS
There were no significant differences between each drug and corresponding placebo on either systolic or diastolic function. When we compared both drugs, patients showed a milder increase in area under E after propranolol than after gallopamil (p < 0.008). Clinical episodes of cardiac failure were not reported, and ejection fraction did not change.


CONCLUSIONS
Both gallopamil and propranolol can be used in patients with coronary heart disease and moderately depressed left ventricular ejection fraction.
Servicio de Cardiología, Complejo Hospitalario Insalud, León.
E
E
Simarro
M A
MA
Rodríguez
J
J
Bayón
J A
JA
Lastra
P
P
Prieto
G
G
Suárez
E
E
García Porrero
R
R
Fernández
J
J
Garrido
J
J
Velasco
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015150:Echocardiography, Doppler / Q000187:drug effects / Q000706:statistics & numerical data; D004562:Electrocardiography / Q000187:drug effects / Q000706:statistics & numerical data; D005260:Female; D005711:Gallopamil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*; D016037:Single-Blind Method; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D005711:Gallopamil; D011433:Propranolol
Efecto del gallopamil y del propranolol en pacientes con cardiopatía isquémica y depresión moderada de la función ventricular.