Low spinal and pelvic bone mineral density among individuals with Down syndrome.
The bone mineral density of 15 adults with Down syndrome was compared to 25 control subjects without Down syndrome. Bone mineral density was measured by dual x-ray absorptiometry with a Lunar DPX scanner. Arm, leg, pelvic, and spine bone mineral density was tested. Analysis of covariance was conducted for each variable; Down syndrome was the independent variable, and the covariates were height, lean body mass, fat mass, age, and gender. No significant group differences were found for arm or leg bone mineral density. Individuals with Down syndrome had significantly lower pelvic and spinal bone mineral density. Before adjustment for covariates, percentage difference between group means for spine was 14.5% and for pelvis, 11.6%. Adjusted percentage was 11.1% and 13.9%, respectively. Suggestions for further research were made.
Columbia University College of Physicians and Surgeons, USA.
D
D
Sepúlveda
D B
DB
Allison
J E
JE
Gomez
K
K
Kreibich
R A
RA
Brown
R N
RN
Pierson
S B
SB
Heymsfield
D000328:Adult; D015519:Bone Density / Q000235:genetics*; D004314:Down Syndrome / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis / Q000235:genetics*; D012016:Reference Values; D013122:Spinal Diseases / Q000175:diagnosis / Q000235:genetics