Successful allogeneic bone marrow transplantation in a case with myelodysplastic syndrome which developed following Fanconi anemia.
We report the case of a 14-year-old boy with myelodysplastic syndrome (MDS/RAEB) which developed following Fanconi anemia. The patient received BMT from an HLA-identical sister. Based on the in vitro CY-sensitivity test, 100 mg/kg of CY was administered for conditioning combined with 6 Gy TBI. Mucosal symptoms such as stomatitis, diarrhea and hematuria were severe, but manageable, and engraftment was successful. The patient has maintained normal trilineage hematopoiesis with > 90% Karnofsky score for 30 months with disappearance of a clonal chromosomal abnormality (47,XY, +i(lq)) which was detected before BMT.
Ikushima
S
S
Department of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine, Japan.
Hibi
S
S
Todo
S
S
Sawada
T
T
Matsumoto
Y
Y
Iwami
H
H
Tsunamoto
K
K
Kasubuchi
Y
Y
Yabe
M
M
Kato
S
S
D000293:Adolescent; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use; D005199:Fanconi Anemia / Q000150:complications*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000628:therapy*; D014184:Transplantation, Homologous
D003520:Cyclophosphamide