Advances in surgical care of infants and children with congenital heart disease.
Recent important technical developments in the field of surgery for congenital heart disease have included the Ross pulmonary autograft replacement of the aortic valve, video-assisted thoracoscopic surgery, and the double-switch and switch-Rastelli procedure for congenitally corrected transposition. Although the growth potential of the pulmonary autograft has been confirmed, an important incidence of late aortic regurgitation has been noted. Expanding indications for video-assisted thoracoscopic surgery have been described, including division of the vascular ring. Late hemodynamic assessment after the double-switch or switch-Rastelli procedure will encourage increased application of this repair. Both clinical and laboratory studies have focused on neurologic and developmental outcome after cardiac surgery. Perioperative seizures in young infants have been found to be associated with impaired psychomotor development at 1 year of age. In the area of perioperative management, the antifibrinolytic agents tranexamic acid, epsilon-aminocaproic acid, and aprotinin have been found to be useful in reducing postoperative hemorrhage. Nitric oxide is useful in reducing postoperative pulmonary hypertension. Late clinical follow-up studies of patients with single ventricle have revealed an important incidence of pulmonary arteriovenous malformations after a bidirectional Glenn shunt and atrial flutter after a Fontan procedure. Late assessment of patients after the arterial switch procedure for transposition has revealed preservation of ventricular function and an extremely low incidence of late arrhythmias.
Children's Hospital, Department of Cardiac Surgery, Boston, MA 02115, USA.
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Jonas
D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery; D016063:Blood Loss, Surgical / Q000517:prevention & control; D002545:Brain Ischemia / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D004724:Endoscopy; D018729:Fontan Procedure; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000517:prevention & control; D007223:Infant; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D011664:Pulmonary Valve / Q000637:transplantation; D013906:Thoracoscopy; D014182:Transplantation, Autologous; D014188:Transposition of Great Vessels / Q000601:surgery
D000933:Antifibrinolytic Agents; D009569:Nitric Oxide