[Expression of MIB-1/KI-67 and bcl-2 in gastric carcinoma. Relationship with clinico-pathological factors].
Neoplastic development partly depends on a balance between cellular proliferative activity and the eventual suppression of the mechanism of apoptosis. Proliferative activity can be estimated by quantification of KI-67 antigen that appears during phases G1, S, G2 and M of the cellular cycle, whereas apoptosis is shown by the expression of the bcl-2 protein. In this study the expression of KI-67 and bcl-2 antigens was examined in a series of 97 gastric adenocarcinomas, to find out their relations with different clinical and pathological factors. The results showed that the expression of KI-67 was only associated to histological grade and did not have any prognostic significance. On the other hand, there was a better 5 year survival rate when invasion did not go beyond the muscularis propria, there were no lymph node metastases, in the woman and when tumors were located in the antrum. bcl-2 protein was surprisingly negative in all cases albeit of previous descriptions of overexpression of this protein in cases of gastric dysplasia. It is postulated that expression of bcl-2 could appear at an early stage of gastric carcinogenesis and that only a small proportion of malignant tumors would maintain that overexpression.
Hospital Privado de Comunidad, Mar del Plata, Argentina.
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Sundblad
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Tamayo
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D000912:Antibodies, Neoplasm / Q000032:analysis; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D019394:Ki-67 Antigen; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics*; D009687:Nuclear Proteins / Q000032:analysis / Q000235:genetics*; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2
Expresion de MIB-1/KI-67 y de bcl-2 en el carcinoma gástrico. Relación con factores clínico-patológicos.