Chronic treatments with 5-HT1A agonists attenuate posthypoxic myoclonus in rats.
Following 10 min cardiac arrest and resuscitation, male Sprague-Dawley rats developed posthypoxic myoclonus. This phenomenon peaked at 14 days and disappeared by 60 days after cardiac arrest. From previous results, the 5-hydroxytryptamine (5-HT) system was implicated in the pathogenesis of the disease. In the present study, we investigated the involvement of 5-HT1A receptors in posthypoxic myoclonus in rats. Single injections of 5-HT1A agonists, buspirone (5 and 10 mg/kg body wt.) or 8-OH-DPAT (1, 2, and 4 mg/kg), had no effect on either the intensity or time course of the disease. In contrast, multiple injections (twice a day for 7 or more days) of buspirone (10 mg/kg) or 8-OH-DPAT (4 mg/kg) significantly attenuated the myoclonus scores of animals (p < 0.05). The results indicate that chronic stimulation of 5-HT1A receptors in the brain may accelerate endogenous compensatory mechanisms and shorten the time course of the disease.
Jaw
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SP
Parkinson and Movement Disorders Laboratory, Department of Neurology, University of California Irvine 92717, USA.
Dang
T
T
Truong
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DD
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D006323:Heart Arrest / Q000139:chemically induced / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000150:complications*; D008297:Male; D008954:Models, Biological; D009207:Myoclonus / Q000188:drug therapy* / Q000209:etiology; D011189:Potassium Chloride; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012702:Serotonin Antagonists / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*
D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D011189:Potassium Chloride