[Appearance of anti-DNA antibodies after treatment with interferon in a patient with chronic type C viral hepatitis].
The development of autoantibodies and autoimmune reactions has been reported during and after interferon (IFN) therapy. We report the case of a 55-years-old woman who developed anti-DNA and anti-nuclear antibodies after a 9 months treatment with alpha-IFN for chronic hepatitis C. Autoantibodies appearance has not modified the response to therapy; no clinical sign of autoimmune disease is appeared in a 5 months follow-up. HLA typing didn't show a genetic predisposition for the development of autoimmune reactions.
Divisione di Medicina Generale, Ospedale S. Camillo, Comacchio (FE), Italy.
P
P
Ballardini
I
I
Cicognani
E
E
Montanari
F
F
Fabbri
R
R
Ferrari
A
A
Del Noce
D000974:Antibodies, Antinuclear / Q000276:immunology*; D002467:Cell Nucleus / Q000276:immunology; D004247:DNA / Q000276:immunology*; D005260:Female; D006526:Hepatitis C / Q000276:immunology / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011994:Recombinant Proteins
D000974:Antibodies, Antinuclear; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D004247:DNA
Comparsa di anticorpi anti-DNA dopo trattamento con interferone in un paziente con epatite virale cronica di tipo C.