Association of biogenic amine metabolites with symptomatology in delusional (psychotic) and nondelusional depressed patients.
1. The levels of the main norepinephrine, serotonin, and dopamine metabolite excretion in the urine, MHPG, 5HIAA and HVA respectively, were measured in 84 patients with major depressive disorder, 34 delusional (psychotic) and 50 nondelusional (DSM-III-R criteria). 2. Associations with the 17 items of the HDRS were evaluated using the multiple regression analysis model. In the delusional group, MHPG excretion was positively related to the scores in the items of depressed mood (p = 0.04), middle insomnia (p = 0.008) and genital symptoms (p = 0.001). 5HIAA excretion was negatively associated with late insomnia (p = 0.02), work and interests (p = 0.001) and genital symptoms (p = 0.007). HVA was positively related to agitation (p = 0.043). In the nondelusional group the only association found was between agitation and HVA excretion (p = 0.03).
Athens University Medical School, Psychiatric Clinic, Greece.
L
L
Lykouras
M
M
Markianos
J
J
Hatzimanolis
D
D
Malliaras
C
C
Stefanis
D000328:Adult; D001679:Biogenic Amines / Q000378:metabolism*; D003702:Delusions / Q000175:diagnosis* / Q000652:urine; D003866:Depressive Disorder / Q000175:diagnosis / Q000652:urine*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000378:metabolism / Q000652:urine*
D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine