[Hereditary solitary adenoma].
Hereditary solitary adenomas is characterized by a low number of adenomatous polyps (usually fewer than 100), but still carries an elevated risk of colon cancer. This colon cancer susceptibility disorder is believed to be inherited as an autosomal dominant. Recent molecular studies have revealed that the mutant alleles responsible for this disorder is mapped to the adenomatous polyposis coli (APC) locus on human chromosome 5q. The average age at onset for developing cancer is approximately 15 years later than that observed in classical APC and approximately 10 years earlier than patients with sporadic colorectal cancer.
Second Department of Surgery, Hyogo College of Medicine.
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Yoshikawa
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Utsunomiya
D018256:Adenomatous Polyps / Q000175:diagnosis / Q000235:genetics*; D017668:Age of Onset; D000483:Alleles; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics*; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D012306:Risk