Retrieval from semantic memory may be normal in multiple sclerosis patients: a study of free word association.
Increased effort of retrieval from memory is considered to be a feature of cognition in subcortical neurological diseases, such as multiple sclerosis (MS). Free word association provides a means to investigate alterations in automatic and effortful retrieval. Using this procedure we investigated whether in MS free word association would shift from commonality towards idiosyncrasy, as a result of effortful, controlled retrieval. The MS group consisted of a cohort of outpatients, who suffered from chronic but quiescent MS. The patients responded with perfectly normal association patterns. Apparently, impairment of retrieval, or more specifically increased effort of retrieval, from memory does not hold true generally in MS. In patients with obvious physical handicaps (mean Kurtzke DSS = 4 +/- 2) we could not demonstrate abnormal associative processes.
Department of Neuropsychology, University Hospital Leiden, Netherlands.
M J
MJ
Pijpers-Kooiman
E A
EA
van der Velde
A
A
Jennekens-Schinkel
D000328:Adult; D005260:Female; D005608:Free Association; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008606:Mental Processes / Q000502:physiology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000523:psychology*; D012660:Semantics