Secretion is a stimulus for the synthesis of human chorionic gonadotrophin by first trimester human placenta.
Time course of release of immunoreactive hCG to a placental incubation in the medium revealed a steady increase over a period of 4 hours. However, levels in the tissue, showed an increase at 10' and 60' after an initial decrease. Studies using A23187 which stimulated secretion also revealed a net increase in the quantity of hCG in the tissue. These results suggest that the secretion of hCG acts as a stimulus for fresh synthesis of hCG.
Department of Biochemistry, Indian Institute of Science, Bangalore, India.
S C
SC
Sharma
A J
AJ
Rao
D000032:Abortion, Therapeutic; D000001:Calcimycin / Q000494:pharmacology; D006063:Chorionic Gonadotropin / Q000096:biosynthesis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010920:Placenta / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013997:Time Factors
D006063:Chorionic Gonadotropin; D000001:Calcimycin