Perspectives and future directions. Immunogenetics.
An outline of the history of immunogenetics is presented. The usefulness of the Rh, HLA and Gm systems in disease prediction and prevention will increase with our capacity precisely to relate polymorphic variants to particular functions and pathophysiological events. Alloimmunization to Gm markers is common in rheumatoid arthritis, an allegedly autoimmune disease. This paradox and the paradox of nonnominal allotypes, disobeying Mendelian rules, are resolved by the interpretation that herpesviruses may transfer nonself polymorphic genes. Transduction of such genes may be important also in AIDS pathogenesis.
Grubb
R
R
Department of Medical Microbiology, University of Lund, Sweden.
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D001789:Blood Group Antigens / Q000235:genetics; D004198:Disease Susceptibility / Q000276:immunology; D005544:Forecasting; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D049673:History, 20th Century; D006801:Humans; D007125:Immunogenetics / Q000266:history / Q000639:trends*; D007126:Immunoglobulin Allotypes / Q000235:genetics; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000266:history; D018570:Risk Assessment; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology
D001789:Blood Group Antigens; D006680:HLA Antigens; D007126:Immunoglobulin Allotypes; D012204:Rh-Hr Blood-Group System