Regulation of adenosine receptors in cultured heart cells.
A1 adenosine receptors were studied on heart cells grown in cultures by the radioligand binding technique. Treatments with agents that accelerated heart rate for 3-4 days, caused an increase in the level of adenosine receptors. Treatments that attenuated heart rate, reduced the level of the receptors. Thus, the cardiac cells respond to environmental conditions affecting heart contraction so as to restore the basal rate of heart activity.
Otto Meyerhoff Drug Receptor Center, Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
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el-Ani
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Jacobson
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Shainberg
D000818:Animals; D002478:Cells, Cultured; D004558:Electric Stimulation; D006339:Heart Rate; D009206:Myocardium / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism*
D018047:Receptors, Purinergic P1