Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.
Jhiang
S M
SM
Department of Physiology and Internal Medicine, Ohio State University, Columbus 43210, USA.
Sagartz
J E
JE
Tong
Q
Q
Parker-Thornburg
J
J
Capen
C C
CC
Cho
J Y
JY
Xing
S
S
Ledent
C
C
D000818:Animals; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D029721:Drosophila Proteins; D018628:Gene Dosage; D015870:Gene Expression; D051379:Mice; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
D029721:Drosophila Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C494999:Ret protein, mouse