Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations.
Highly specific immunoradiometric assays were used to measure plasma concentrations of insulin, proinsulin, and 32-33 split proinsulin in neonates (n = 16). Neonatal plasma insulin concentrations were high relative to blood glucose concentrations and compared with adult insulin-glucose relations. Concentrations of proinsulin and 32-33 split proinsulin together accounted for 34-70% of the total concentration of insulin and pro-peptides. This study confirms the need to use a specific assay and neonatal reference data in the diagnosis of neonatal hyperinsulinism, and shows that neonatal pancreatic beta cell function may differ from that of older subjects.
Hawdon
J M
JM
Institute of Child Health, Liverpool University.
Hubbard
M
M
Hales
C N
CN
Clark
P M
PM
D001786:Blood Glucose; D005865:Gestational Age; D006801:Humans; D015592:Immunoradiometric Assay; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007328:Insulin / Q000097:blood*; D011384:Proinsulin / Q000097:blood; D011498:Protein Precursors / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D011498:Protein Precursors; C070703:proinsulin, des(31,32)-; D011384:Proinsulin