[Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance].
BACKGROUND
Mild methemoglobinemia is a known side-effect of one of the constituents of EMLA cream, this topical local anesthetic is used with great caution in neonates.


METHODS
One hundred and sixteen neonates admitted from January to July 1994 in an intensive care unit were included in the study. All required skin punctures which were performed 1 h 30-2 hours after EMLA had been applied on the skin. A reaction score (0 to 5) to skin puncture was established 157 times (120 after and 37 without local anesthesia); methemoglobin (Met Hb) concentrations were measured in 47 blood samples, 18-24 hours (40.4% of samples) or 2-3 days (36.2%) after application of EMLA.


RESULTS
Ninety-four neonates were quiet before puncture (score 0-1). Among them, 57% of those who were given EMLA had a low score (2 or less) vs 18% without EMLA. A low reaction was observed in 65% when the dressings had been kept in place for at least 90 minutes vs 15% with a shorter application. A lower reaction was noted in 78.8% of cases after venopuncture (41% after arterial puncture). No Met Hb level was above 5% and 7 (15%), in five neonates, were between 3 and 5%. There was no clear relationship between methemoglobinemia and gestational age or duration of dressing.


CONCLUSIONS
EMLA cream is effective and safe in neonates including preterms, when it is applied in a small amount once a day.
Service de néonatalogie, hôpital René-Dubos, Pontoise, France.
E
E
Gourrier
P
P
Karoubi
A
A
el Hanache
S
S
Merbouche
G
G
Mouchnino
S
S
Dhabhi
J
J
Leraillez
D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004361:Drug Tolerance; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects; D000077442:Lidocaine, Prilocaine Drug Combination; D008708:Methemoglobinemia / Q000139:chemically induced*; D009824:Ointments; D011318:Prilocaine / Q000008:administration & dosage* / Q000009:adverse effects
D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine
Utilisation de la crème EMLA chez le nouveau-né à terme et prématuré. Etude d'efficacité et de tolérance.