TNF alpha interrupts antigen-presenting function of Langerhans cells by two mechanisms: loss of immunogenic peptides and impairment of antigen-independent T cell clustering.
Koch
F
F
Department of Dermatology, University of Innsbruck, Austria.
Kämpgen
E
E
Trockenbacher
B
B
Schuler
G
G
Romani
N
N
D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects*; D002449:Cell Aggregation / Q000187:drug effects / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D066298:In Vitro Techniques; D007801:Langerhans Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D000949:Histocompatibility Antigens Class II; D010455:Peptides; D014409:Tumor Necrosis Factor-alpha