[Skin and gene therapy. Hopes and realities].
Genetic therapy is developing rapidly in dermatology. Because they are highly accessible and can be cultured and grafted, skin cells are an excellent application for this still experimental therapeutic approach. There are several possible applications in skin diseases. In this review we discuss the techniques of gene transfer, experimental results and future perspectives as well as the limitations of this new therapeutic strategy.
Service de Dermatologie, Hôpital Bichat (Paris)
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Descamps
D000256:Adenoviridae / Q000235:genetics; D005347:Fibroblasts / Q000166:cytology; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D015603:Keratinocytes / Q000166:cytology; D012190:Retroviridae / Q000235:genetics; D012871:Skin Diseases / Q000235:genetics / Q000628:therapy*; D014162:Transfection / Q000379:methods*
Peau et thérapie génique. Espoirs et réalités.