Renal reserve: a functional view of glomerular filtration rate.
The hyperfiltration theory challenged the view that glomerular filtration rate is a fixed function as well as that there is a good correlation between GFR and renal parenchymal damage. Glomerular filtration rate is a dynamic parameter that is diet-dependent and can be altered by hemodynamic maneuvers. Therefore, it is not a good indicator of renal lesion. The renal reserve is an indicator of the workload per nephron and may be a useful parameter to assess the progression of renal disease in the presence of dietary or pharmacological intervention.
Division of Renal Diseases and Hypertension, George Washington University, Washington, DC 20037, USA.
J P
JP
Bosch
D004044:Dietary Proteins / Q000008:administration & dosage; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology
D004044:Dietary Proteins