Changes in a CSF antigen associated with dementia.
An 85-kDa antigen was detected in cerebrospinal fluid (CSF) using a monoclonal antibody, 11.57, raised against a fraction of paired helical filaments extracted from Alzheimer's disease (AD) brain tissues. The antigen is a thermostable protein that is unrelated either to tau or amyloid beta-protein precursor. Its level was measured in lumbar and post-mortem CSF samples and found to be decreased significantly in patients with dementia as compared with non-demented controls. There was no difference in its level between patients with AD and those with non-Alzheimer type dementia. In AD, however, there was a significant relationship between disease progression and the amount of the 85-kDa antigen.
Cambridge Brain Bank Laboratory, University of Cambridge Department of Psychiatry, UK.
M T
MT
Carretero
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Harrington
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CM
Wischik
D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000276:immunology; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000134:cerebrospinal fluid / Q000276:immunology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000276:immunology; D016875:tau Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens; D016875:tau Proteins