Antibody engineering.
Antibody engineering has been an extremely intensive research area for many years. Recent achievements discussed in this review include: (i) significant improvements in the field of selection of antigen-specific antibody fragments on bacteriophages; (ii) new structural work, in particular using NMR; (iii) the cloning of essentially the complete set of human VH genes; (iv) the use of antibodies to catalyze complicated chemical reactions; and (v) novel antibody fusion proteins to potentiate immune therapy. An interesting new development is the replacement of antibodies with more stable protein scaffolds for many future biotechnological applications.
Pharmacia AB, Department of Structural Biology, Stockholm, Sweden.
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Nilsson
D000906:Antibodies / Q000737:chemistry* / Q000235:genetics; D000917:Antibody Formation; D001435:Bacteriophages / Q000235:genetics; D006801:Humans; D011487:Protein Conformation; D015202:Protein Engineering
D000906:Antibodies