Platinum(II) complexes of 4-methoxy- and 4-chlorobenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect.
The complexes [Pt(NH3)(pmbah)Cl2], [Pt(NH3)(pcbah)Cl2], [Pt(pmbah)2X2] and [Pt(pcbah)2X2] (pmbah = 4-methoxybenzoic acid hydrazide, pcbah = 4-chlorobenzoic acid hydrazide; X = Cl, Br, I) have been synthesized and characterized by elemental analysis, electric conductivity, 1H NMR, IR, and electronic spectra. A cis-square planar structure with hydrazide ligands coordinated via the NH2 groups has been proposed for these compounds. The complexes, but not the free ligands, have shown a strong growth inhibitory effect in Friend leukemia cells in vitro, most of which are more active than cisplatin.
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
N
N
Dodoff
K
K
Grancharov
N
N
Spassovska
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002723:Chlorobenzoates / Q000737:chemistry; D005622:Friend murine leukemia virus; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000737:chemistry; D007939:Leukemia L1210 / Q000188:drug therapy*; D004915:Leukemia, Erythroblastic, Acute; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002723:Chlorobenzoates; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D009944:Organoplatinum Compounds; C004520:4-anisic acid; C040768:4-chlorobenzoic acid