Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse.
The analgesic effects of the nonsteroidal anti-inflammatory drugs, ketoprofen (2.2 and 3.63 mg/kg bwt) and phenylbutazone (4.4 mg/kg bwt) were compared in 7 horses with chronic laminitis. Hoof pain was quantified objectively by means of an electronic hoof tester and lameness was subjectively graded on a modified Obel scale. Ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) reduced hoof pain and lameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. These effects were still present at 24 h in 3 of the 4 pain tests, including lameness grade. These data suggest that ketoprofen at the dosage rate of 1.65 times the recommended therapeutic dose was more potent than phenylbutazone in alleviating chronic pain and lameness in horses.
Department of Veterinary Physiology, Pharmacology and Toxicology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
J G
JG
Owens
S G
SG
Kamerling
S R
SR
Stanton
M L
ML
Keowen
D000698:Analgesia / Q000662:veterinary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D005534:Foot Diseases / Q000188:drug therapy / Q000662:veterinary; D006724:Hoof and Claw; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007660:Ketoprofen / Q000627:therapeutic use*; D007794:Lameness, Animal / Q000188:drug therapy*; D008297:Male; D015999:Multivariate Analysis; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010653:Phenylbutazone / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen; D010653:Phenylbutazone