Modeling the leech heartbeat elemental oscillator. II. Exploring the parameter space.
In the previous paper, we described a model of the elemental heartbeat oscillator in the leech. Here, the parameters of our model are explored around the baseline canonical model. The maximal conductances of the currents and the reversal potential of the leak current are varied to reveal the effects of individual currents and the interaction between synaptic and intrinsic currents in the model. The model produces two distinct modes of oscillation as the parameters are varied, S-mode and G-mode. These two modes are defined, their origin is identified, and the parameter space is mapped into S-mode and G-mode oscillation and no oscillation. Finally, we will make predictions for how the period can be modulated in heart interneurons.
Department of Biology, Emory University, Atlanta, GA 30322, USA.
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Olsen
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Nadim
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Calabrese
D000818:Animals; D002118:Calcium / Q000502:physiology; D006321:Heart / Q000294:innervation* / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D007865:Leeches / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011188:Potassium / Q000502:physiology; D012964:Sodium / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D012964:Sodium; D011188:Potassium; D002118:Calcium