Synthesis of two peptide scorpion toxins and their use to investigate the aortic tissue regulation.
The 37 amino acid residue polypeptides iberiotoxin and charybdotoxin, which contain three disulfide bridges, were chemically synthesized and characterized. The physiological effectiveness of these peptides was tested on rabbit aorta in vitro.
Tóth
G K
GK
Department of Medical Chemistry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Pataricza
J
J
Janáky
T
T
Mák
M
M
Zarándi
M
M
Papp
J G
JG
Penke
B
B
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta / Q000187:drug effects*; D018999:Charybdotoxin / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011817:Rabbits
D000316:Adrenergic alpha-Agonists; D010455:Peptides; D018999:Charybdotoxin; D010656:Phenylephrine; C064719:iberiotoxin