Evaluation of dopexamine hydrochloride as a renoprotective agent during aortic surgery.
Thirty-two patients undergoing elective infrarenal aortic surgery were randomly assigned to receive a perioperative infusion of either dopexamine hydrochloride at a rate of 2 micrograms/kg/min (n = 15) or 0.9% saline solution as placebo (n = 17). Renal function was monitored by regular measurements of serum creatinine levels. There were significant mean percentage increases in serum creatinine (p < 0.001) at all time points up to 3 days postoperatively in the placebo group but only at 2 and 12 hours in the dopexamine group. It was concluded that dopexamine hydrochloride confers renal protection in patients undergoing aortic reconstruction.
Welch
M
M
Department of Vascular Surgery, Manchester Royal Infirmary, U.K.
Newstead
C G
CG
Smyth
J V
JV
Dodd
P D
PD
Walker
M G
MG
D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology / Q000601:surgery*; D001018:Aortic Diseases / Q000503:physiopathology / Q000601:surgery*; D001157:Arterial Occlusive Diseases / Q000503:physiopathology / Q000601:surgery*; D003404:Creatinine / Q000378:metabolism; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D017558:Elective Surgical Procedures; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests
D018491:Dopamine Agonists; C046318:dopexamine; D003404:Creatinine; D004298:Dopamine