Role of receptors in human and rodent hepatocarcinogenesis.
The liver is a major target organ in rodent carcinogenicity assays. Amongst the agents that are effective in producing rodent liver tumours are many chemicals which are not mutagenic, but are believed to mediate their effects by promoting the clonal outgrowth of initiated cells. Some of these chemicals, such as dibenzo-p-dioxins and certain PCBs, have been demonstrated to interact with specific cellular receptors and receptor binding appears crucial for their tumourigenic activity. Enzyme-altered foci in rat liver may serve as a sensitive means to estimate the promoting activity of these agents in rodents. Mechanistic considerations are of relevance when extrapolating these data from rodents to humans.
Institute of Toxicology, University of Tübingen, Germany.
M
M
Schwarz
A
A
Buchmann
S
S
Stinchcombe
G
G
Luebeck
S
S
Moolgavkar
K W
KW
Bock
D000818:Animals; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D051379:Mice; D009154:Mutation; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology*
D000072317:Polychlorinated Dibenzodioxins; D011956:Receptors, Cell Surface; D011078:Polychlorinated Biphenyls