A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa.
A community-based study of provirus load in human immunodeficiency virus (HIV) type 2-infected subjects was done in a rural village in Guinea-Bissau. HIV-2 provirus load varied considerably, with a geometric mean of 124.3 (95% confidence interval, 86.0-179.6) copies/10(5) CD4 cells, which is a level similar to that found in HIV-1 infection. Neither malaria parasitemia, active syphilis, or human T cell leukemia virus coinfection significantly influenced provirus load, nor did age. Eleven of 104 HIV-2-infected subjects had died after 3 years of follow-up; 9 of those who died had a high provirus load of > or = 100 copies/10(5) CD4 cells and a relatively low CD4 cell percentage of < 29%.
Ariyoshi
K
K
Medical Research Council Laboratories, Banjul, Gambia.
Berry
N
N
Wilkins
A
A
Ricard
D
D
Aaby
P
P
Nauclér
A
A
Ngom
P T
PT
Jobe
O
O
Jaffar
S
S
Dias
F
F
Tedder
R S
RS
Whittle
H
H
D000328:Adult; D000367:Age Factors; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006169:Guinea-Bissau / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D015528:HIV Seroprevalence; D015498:HIV-2 / Q000502:physiology; D015490:HTLV-I Infections / Q000150:complications; D006801:Humans; D008288:Malaria / Q000150:complications; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D011533:Proviruses / Q000502:physiology; D012424:Rural Population / Q000706:statistics & numerical data; D013587:Syphilis / Q000150:complications
D004279:DNA, Viral