Time course and mechanisms of decreased plasma volume during acute psychological stress and postural change in humans.
In this study, we examined the effects of psychological stress on calculated plasma volume, the relationship of these changes to changes in hematologic and hemodynamic factors, and the time course of plasma volume changes. Plasma volume changes were assessed using mass densitometry techniques, which measured changes in blood and plasma density. Hematologic and hemodynamic variables were assessed in 40 healthy men and women during a mental arithmetic (math) or benign reading task and during postural change (standing). Results indicated that math and posture change produced a significant decrease in plasma volume (ps < .001) and increases in blood pressure (ps < .001), blood and plasma density (ps < .001), and total plasma protein (p < .001). Correlations were observed between plasma volume changes and changes in systolic (r = .55, p < .0001), diastolic (r = .61, p < .0001), and mean (r = .65, p < .0001) arterial pressure during math; plasma volume and blood pressure returned to baseline within 12 min following the math task. These results suggest that an important mechanism for stress-induced decreases in plasma volume is increased blood pressure leading to increased fluid shifts from the vasculature into the interstitial spaces.
Patterson
S M
SM
Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Krantz
D S
DS
Jochum
S
S
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*