[Current aspects of the use of clozapine in the Châlons-sur-Marne Psychiatric Hospital: intestinal occlusion with clozapine].
The authors report three cases--one of them lethal--of intestinal occlusion among 30 patients treated with clozapine between 1991 and 1994 in Châlons-sur-Marne Psychiatric Hospital. The responsibility of clozapine seems to be linked with its potent anticholinergic property. The attention of prescriptors is necessary and the monitoring of the drug should not be limited to the hematologic aspect.
Centre régional de Pharmacovigilance (Pr H. Choisy), CHU, Hôpital de la Maison-Blanche, Reims.
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L
Théret
M L
ML
Germain
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A
Burde
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D003248:Constipation / Q000139:chemically induced; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003024:Clozapine
Actualité de l'utilisation de la clozapine à l'Hôpital psychiatrique de Châlons-sur-Marne: occlusions intestinales sous clozapine.