Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures.
Spirito
S
S
Ciba-Geigy Corp., Research Department, Summit, NJ 07901, USA.
Doughty
J
J
O'Byrne
E
E
Ganu
V
V
Goldberg
R L
RL
D000818:Animals; D002356:Cartilage / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D003094:Collagen / Q000378:metabolism*; D006877:Hydroxamic Acids; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D009297:Nasal Mucosa / Q000378:metabolism*; D009666:Nose / Q000187:drug effects; D009924:Organ Culture Techniques; D011480:Protease Inhibitors / Q000494:pharmacology*; D011509:Proteoglycans / Q000378:metabolism; D011719:Pyrazines; D013449:Sulfonamides
C097658:CGS 27023A; D006877:Hydroxamic Acids; D007375:Interleukin-1; D011480:Protease Inhibitors; D011509:Proteoglycans; D011719:Pyrazines; C097661:Ro 31-9790; D013449:Sulfonamides; D003094:Collagen; D008666:Metalloendopeptidases