A simple and efficient method to remove free radioiodide from *I-radiopharmaceuticals.
Removal of free radioiodide from *I-radiopharmaceuticals was easily performed by using a pure metallic silver membrane, placed in a screwable holder. Well-known radiopharmaceuticals such as 3-iodobenzylguanidine, Hippuran, iomazenil and fatty acids were treated successfully, and gave reproducible results. Only a trace of free radioiodide (< or = 1%) was left after passing the silver membrane, while rest activity due to retention of the radiopharmaceutical on the membrane was negligible (2%-5%). This simple and reliable method offers the possibility of application as a last purification step in routine productions, in research or in a nuclear medicine department's pharmacy.
Radionuclide Centre, Free University, Amsterdam, The Netherlands.
J L
JL
Eersels
F G
FG
Custers
G J
GJ
Ensing
J D
JD
Herscheid
D005374:Filtration; D006801:Humans; D007454:Iodides; D007457:Iodine Radioisotopes; D008567:Membranes, Artificial; D012834:Silver
D007454:Iodides; D007457:Iodine Radioisotopes; D008567:Membranes, Artificial; D012834:Silver