Blood conservation strategies to minimize allogeneic blood use in urologic surgery.
Analysis of the net costs, efficacy, and cost-effectiveness of preoperative autologous blood donation (PAD), versus acute normovolemic hemodilution (ANH), in patients undergoing radical prostatectomy is presented. Currently, PAD is a standard of care for patients undergoing radical prostatectomy. Comparison of PAD with ANH showed no differences in risks or outcome, but ANH was less expensive. Hemodilution is a simple, safe, convenient, and effective alternative to PAD. The use of recombinant human erthropoietin in conjunction with PAD and ANH has optimized perioperative hematocrits and further minimized exposure to allogeneic blood. Intraoperative blood salvage, lower transfusion triggers, and other blood conservation strategies are discussed. The most cost-effective techniques currently available for decreasing allogeneic blood transfusions appear to be avoidance of blood loss, increased tolerance for decreased HCT levels, and autologous blood procurement via ANH.
Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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Monk
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Goodnough
D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion / Q000191:economics; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D003362:Cost-Benefit Analysis; D004921:Erythropoietin / Q000008:administration & dosage; D006400:Hematocrit; D006438:Hemodilution / Q000191:economics; D006801:Humans; D007432:Intraoperative Period; D011300:Preoperative Care; D011994:Recombinant Proteins / Q000008:administration & dosage; D014570:Urologic Diseases / Q000601:surgery*
D011994:Recombinant Proteins; D004921:Erythropoietin