A steric approach for the design of antihistamines with low muscarinic receptor antagonism.
Leiden/Amsterdam Center for Drug Research, Vrije Universiteit, The Netherlands.
M Q
MQ
Zhang
K
K
Walczynski
H
H
Timmerman
D000818:Animals; D002090:Butyrophenones / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D015394:Molecular Structure; D018727:Muscarinic Antagonists / Q000737:chemistry* / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D018727:Muscarinic Antagonists; D010880:Piperidines; C058249:ebastine