Enteropathy-associated T-cell lymphoma in the West of Ireland: low-frequency of Epstein-Barr virus in these tumors.
The Epstein-Barr virus has been implicated in the etiology of endemic Burkitt's lymphoma, post-transplant lymphoma, large-cell anaplastic CD30 (Ki-1)-positive lymphoma, and in many T-cell lymphomas. A recent report has found Epstein-Barr virus genome in association with 4 of 11 cases (36%) of enteropathy-associated T-cell lymphoma. In a retrospective study, we have characterized 22 consecutive cases of enteropathy-associated T-cell lymphoma from the West of Ireland where celiac disease is endemic. All cases were immunophenotyped with T- and B-cell markers including the anaplastic large-cell lymphoma marker CD30 or Ki-1. Nineteen cases were studied for latent membrane protein expression and 16 for Epstein-Barr virus small RNAs by in situ hybridization using EBER oligonucleotides on routinely processed sections. Only 1 of 16 cases (6%) showed Epstein-Barr virus in tumor cells and no cases stained with latent membrane protein. Eight of 22 cases (36%) including the EBER-positive case were positive for CD30. These results suggest that the Epstein-Barr virus does not commonly play a role in the pathogenesis of enteropathy-associated T-cell lymphoma from this area.
Walsh
S V
SV
Department of Histopathology, University College Hospital, Galway, Ireland.
Egan
L J
LJ
Connolly
C E
CE
Stevens
F M
FM
Egan
E L
EL
McCarthy
C F
CF
D015703:Antigens, CD / Q000032:analysis; D002446:Celiac Disease / Q000150:complications*; D002467:Cell Nucleus / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D007494:Ireland; D017730:Ki-1 Antigen / Q000032:analysis; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012189:Retrospective Studies; D014763:Viral Matrix Proteins / Q000032:analysis
D015703:Antigens, CD; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D017730:Ki-1 Antigen; D012367:RNA, Viral; D014763:Viral Matrix Proteins