Abnormalities of regional distribution of cerebral vasculature in schizophrenia detected by dynamic susceptibility contrast MRI.
OBJECTIVE
The authors tested the hypothesis that the regional distribution of cerebral vasculature is anomalous in schizophrenia.


METHODS
Dynamic susceptibility contrast magnetic resonance imaging was used to evaluate cerebral blood volume in the right and left occipital cortex, basal ganglia, and cerebellum of 10 subjects with schizophrenia and 10 healthy comparison subjects.


RESULTS
Cerebral blood volume was greater in the schizophrenic subjects in every region studied.


CONCLUSIONS
The findings suggest an abnormality of the configuration of cerebral blood vessels in schizophrenia.
Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA.
B M
BM
Cohen
D
D
Yurgelun-Todd
C D
CD
English
P F
PF
Renshaw
D000328:Adult; D001479:Basal Ganglia / Q000098:blood supply; D001808:Blood Vessels / Q000503:physiopathology; D002531:Cerebellum / Q000098:blood supply; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging; D005260:Female; D007839:Functional Laterality; D005682:Gadolinium; D006571:Heterocyclic Compounds; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000098:blood supply; D009942:Organometallic Compounds; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology
D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium