[The influence of modified sequential therapy on lipid metabolism in postmenopausal women].
The study was performed in 50 women aged 49 to 55 years, divided into two groups. Group I received transdermally at a rising dose of 2 to 8 mg, altogether 16 mg during the therapeutic cycle of 20 days. Group II received estriol intravaginally 0.03 mg/day 10 days and 0.06 mg/day for 10 days. During the second part of the therapeutic cycle all women were given progesterone sublingually 25 mg/day for 6 days and 50/day for 6 days. Measurements in serum of total cholesterol, free cholesterol and triglycerides using an enzymic method, of HDL-Ch and LDL-Ch using a precipitation method and of cholesterol esters using thing-layer chromatography were performed before and after 3 months of therapy. It was found that the use of estradiol leads to a significant decrease in the level of triglycerides, total and free cholesterol, LDL-Ch, with a rise in HDL-Ch. The use of estriol leads to a decrease in LDL-Ch only. No changes in the composition of cholesterol esters were found in both groups, with the exception of an insignificant rise in the percentage of cholesterol oleate.
Kliniki Ginekologii Instytutu Połoznictwa i Ginekologii AM w Szczecinie.
S
S
b1anosz
B
B
Lisiecka
T
T
Wesołowska
G
G
Sycz
K
K
Goertz
D
D
Kuligowski
B
B
Kościuszkiewicz
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004334:Drug Administration Schedule; D004958:Estradiol / Q000008:administration & dosage; D004964:Estriol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D011374:Progesterone; D004958:Estradiol; D002784:Cholesterol; D004964:Estriol
Wpływ własnej modyfikacji sekwencyjnej estrogenoterapii na przemiany lipidowe u kobiet w okresie pomenopauzalnym.