Two unusual presentations of müllerian adenosarcoma: case reports, literature review, and treatment considerations.
Müllerian adenosarcomas of the uterus usually present as pedunculated endometrial masses in postmenopausal women with vaginal bleeding. Extraendometrial variants (originating in the ovary, adnexa, or myometrium) are much less common, and they tend to present at a more advanced stage due to their location. The sarcomatous portion of müllerian adenosarcoma can vary from low grade to very high grade and the clinical behavior of the tumors can be indolent or aggressive. We present two cases, one of which originated in the adnexa and the other in an apparent focus of uterine adenomyosis. These cases illustrate the difficulty of correct diagnosis and treatment.
Division of Hematology/Medical Oncology, Ida M. and Cecil H. Green Cancer Center, Scripps Clinic and Research Institute, La Jolla, CA 92037, USA.
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R
Gollard
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M
Kosty
G
G
Bordin
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A
Wax
C
C
Lacey
D018195:Adenosarcoma / Q000473:pathology* / Q000628:therapy; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000473:pathology* / Q000628:therapy; D014594:Uterine Neoplasms / Q000473:pathology* / Q000628:therapy