Effect of isolation on behavioural models involving serotonergic 5-HT2 and 5-HT1A receptors.
1. The effect of 7 days of isolation were observed in mice on behavioural models involving 5-HT2 and 5-HT1A receptors. 2. The sensitivity of 5-HT2 receptors as assessed through L-5-HTP or 5-MeODMT induced head-twitches was reduced. 3. The sensitivity of the 5-HT1A receptors implicated in the 8-OH-DPAT induced feeding was unchanged. 4. The sensitivity of the 5-HT1A receptors involved in the 8-OH-DPAT induced hypothermia was diminished. 5. On the whole, these results show that after 7 days of isolation, the responses to the stimulation of serotonergic receptors is unchanged or diminished according to both the receptor's subtype and the model used.
Coudereau
J P
JP
INSERM U26, Hopital Fernand Widal, Paris, France.
Monier
C
C
Frances
H
H
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D007035:Hypothermia; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011985:Receptors, Serotonin / Q000145:classification* / Q000378:metabolism*; D012934:Social Isolation; D013997:Time Factors
D011985:Receptors, Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin