Comparison of rectal to intranasal administration of midazolam for premedication of children.
Sixty children aged 3 to 9, undergoing minor surgical procedures, were studied to compare 0.5 mg/kg intranasal with 0.5 mg/kg rectal midazolam as a premedication. The children were evaluated for their ability to tolerate the medication, preanesthetic sedation, and alertness after anesthesia. Both premedication routes were equally effective in sedating the children. In both groups, a significant loss of effectiveness was noted if induction of the anesthesia began more than 30 minutes after administration of the medication (p < 0.0003). Rectal midazolam was much better tolerated by the children than the intranasal route (30 versus 3, p < 0.0001). We advocate the rectal over the intranasal route for premedication with midazolam in children, and anesthetic induction should occur no more than 30 minutes after administration of premedication.
Khazin
V
V
Department of Anesthesiology, Edith Wolfson Medical Center, Holon, Israel.
Ezra
S
S
Cohen
A
A
D000281:Administration, Intranasal; D000285:Administration, Rectal; D001007:Anxiety / Q000188:drug therapy / Q000517:prevention & control; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D011229:Preanesthetic Medication / Q000009:adverse effects / Q000379:methods*
D008874:Midazolam