Urinary excretion of glycosaminoglycans in patients with superficial bladder tumors.
Urinary glycosaminoglycan/creatinine (GAG/Cr) ratio was determined in 73 patients with superficial bladder tumors and 34 healthy volunteers. While the mean GAG/Cr value in the tumor group was higher than the control group (11.25 +/- 5.36 vs. 10.11 +/- 2.67) this difference was not statistically significant. However, comparing the urinary GAG/Cr ratio of T1, Grade III and recurrent tumors with the control group revealed statistically significant results (p < 0.01, p < 0.001 and p < 0.02 respectively). Therefore, the urinary GAG/Cr ratio determination in the follow-up of these patients may be used as noninvasive procedure and high levels may be signs of higher grade, higher stage disease.
Department of Biochemistry Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
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D000328:Adult; D014408:Biomarkers, Tumor / Q000652:urine*; D003404:Creatinine / Q000652:urine; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000652:urine; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000652:urine; D011237:Predictive Value of Tests; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000652:urine*
D014408:Biomarkers, Tumor; D006025:Glycosaminoglycans; D003404:Creatinine