Inhibition by capsaicin against cyclophosphamide-induced clastogenicity and DNA damage in mice.
We have demonstrated in an earlier paper that capsaicin, the pungent principle of red hot chili, has a potent anti-oxidant property that interferes with free-radical involved mechanisms. In the present paper we demonstrate that capsaicin significantly inhibits cyclophosphamide-induced (i.p.) chromosomal aberrations and DNA strand breakages. This protective action of capsaicin against CP-induced toxicity may possibly be linked with its already reported 'desensitisation' effect against chemical irritant-induced damages.
Department of Biochemistry, University College of Science, Calcutta, India.
A K
AK
De
K
K
Agarwal
A
A
Mukherjee
D
D
Sengupta
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002211:Capsaicin / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*
D009153:Mutagens; D003520:Cyclophosphamide; D002211:Capsaicin