[Familial pituitary tumors].
Familial pituitary tumors are relatively rare. Most commonly, they occur as a part of multiple endocrine neoplasia type 1 (MEN 1). However, familial pituitary adenomas unrelated MEN 1 (familial pituitary adenomas) are extremely rare. In review of MEN 1 in Japan, 60% of the patients with MEN 1 had pituitary tumors. Only 45 cases of familial pituitary adenomas have been reported from 20 families. In our review of familial pituitary adenomas, 30 (67%) of 45 reported cases are acromegaly or gigantism. This incidence is much higher than 28% in MEN 1 patients with pituitary tumors. Allelic deletions at 11q13 were identified in MEN 1 associated pituitary adenomas and familial pituitary adenomas in two gigantism brothers.
Otsuka Department of Clinical and Molecular Nutrition, University of Tokushima.
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Yoshimoto
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Saito
D000172:Acromegaly; D000236:Adenoma / Q000235:genetics*; D000328:Adult; D000483:Alleles; D002880:Chromosomes, Human, Pair 11; D005192:Family Health; D005260:Female; D017353:Gene Deletion; D005877:Gigantism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D010911:Pituitary Neoplasms / Q000235:genetics*