The use of a streamlined bacterial mutagenicity assay, the MINISCREEN.
A streamlined bacterial mutagenicity assay, the MINISCREEN, was developed to enable the rapid screening of a large number of chemical compounds on a purely qualitative basis. Experiments with a series of known carcinogens/mutagens and non-carcinogens/mutagens showed a good correlation with conventional bacterial mutagenicity assays (Ames tests), and the subsequent testing of over 300 candidate agricultural chemicals and over 100 industrial chemicals has proven its value as a screening method.
Corning Hazleton, Harrogate, North Yorkshire, UK.
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Brooks
D000818:Animals; D001431:Bacteriological Techniques; D001711:Biotransformation; D002273:Carcinogens / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D002273:Carcinogens; D009153:Mutagens