Kappa- and lambda-positive cells in centroblastic-centrocytic lymphoma (follicular lymphoma) may share a secondary chromosome aberration: reflections on early lymphoma development.
The technique of simultaneous fluorescence immunophenotyping and interphase cytogenetics (FICTION) was applied in four cases of centroblastic-centrocytic (working formulation: follicular) lymphoma. Our aim in this study was to establish whether secondary chromosome aberrations known from a prior cytogenetic analysis were detectable in both kappa- and lambda-expressing tumor cells from the same lymphoma patient. One of the cases did indeed contain kappa- and lambda-positive tumor cells with trisomy 8. On the basis of our results, we reflect on the events that take place during early development of centroblastic-centrocytic lymphoma.
Department of Human Genetics, University of Kiel, Federal Republic of Germany.
K
K
Weber-Matthiesen
M
M
Winkemann
W
W
Grote
B
B
Schlegelberger
D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014314:Trisomy
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains