BCR-ABL rearrangement and 'variant' Philadelphia chromosome in de novo acute myelogenous leukaemia FAB subtype M1.
We report a case of de novo acute myelogenous leukaemia FAB subtype M1 that presents a cytogenetic complex translocation between chromosomes 7, 9 and 22, producing a 'variant' Philadelphia chromosome. Molecular analysis revealed a BCR-ABL rearrangement involving exons b3 and a2 (b3a2). Haematological parameters and genetic analysis again raise the problem of the true nature of this disease, which is briefly discussed.
Cigudosa
J C
JC
Service of Genetics, Faculty of Medicine, University of La Laguna, Hospital N. Sra. La Candelaria, Tenerife, Spain.
Acosta Almeida
M T
MT
Carrasco
V
V
Bello
T
T
Carrasco
J L
JL
Otero Gómez
A
A
Garcia Talavera
J
J
García Miranda
J L
JL
D000328:Adult; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D004587:Electrophoresis, Agar Gel; D005091:Exons; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D010677:Philadelphia Chromosome; D016133:Polymerase Chain Reaction
D016044:Fusion Proteins, bcr-abl