Topical treatment of early cutaneous T-cell lymphoma.
The two major topical treatment modalities for cutaneous T-cell lymphoma (CTCL) are mechlorethamine (nitrogen mustard) and topical carmustine (BCNU). Topical mechorethamine hydrochloride has been used since the late 1950s as therapy for CTCL. Topical BCNU solution is a highly effective treatment for early stage mycosis fungoides. This article describes these two modalities.
Ramsay
D L
DL
New York University Medical Center, New York, USA.
Meller
J A
JA
Zackheim
H S
HS
D000287:Administration, Topical; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000266:history / Q000627:therapeutic use*; D002330:Carmustine / Q000627:therapeutic use*; D049673:History, 20th Century; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy*; D008466:Mechlorethamine / Q000009:adverse effects / Q000266:history / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*
D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine; D002330:Carmustine