Does dopamine act on myocardial cells?
We examined the electrophysiological effects of dopamine on the single myocardial cells isolated from the rat and rabbit heart. Dopamine at a concentration of 1 or 10 microM did not affect the L-type Ca2+ current (ICa) or the transient outward current (ITO) in rat ventricular, rabbit atrial, ventricular, and sinoatrial node cells. It did not induce any detectable change in the action potential configuration of the rabbit ventricular cells either. We conclude that dopamine does not directly act on myocardial cells at least in terms of the electrophysiological properties.
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan.
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Y
Habuchi
L L
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T
Komori
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Okamoto
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Nishimura
J
J
Morikawa
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Yoshimura
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology*; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000166:cytology*; D018408:Patch-Clamp Techniques; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D015220:Calcium Channels; D004298:Dopamine