A correlation study between serum adenosine deaminase activities and peripheral lymphocyte subsets in Parkinson's disease.
Adenosine deaminase (ADA) and its isozyme activities in serum were measured together with peripheral lymphocyte subsets in 42 patients with idiopathic Parkinson's disease. The total and ADA 2 activities were significantly higher than normal controls (p < 0.01). As regards the peripheral lymphocyte subsets, the proportion of OKT 10+ cells (activated T lymphocytes) and the proportions of interleukin-2 receptor+ and HLA-DR+ cells (mainly activated T lymphocytes) were significantly higher than normal controls (p < 0.05, 0.01, 0.01, respectively). On the other hand, OKT 10+ cells demonstrated a significant correlation not only with total ADA but also with ADA 2 activity. These results suggest that high serum ADA activity may be involved in the pathogenesis of Parkinson's disease through peripheral T lymphocyte activation.
Chiba
S
S
Department of Neurology, School of Medicine, Sapporo Medical University, Japan.
Matsumoto
H
H
Saitoh
M
M
Kasahara
M
M
Matsuya
M
M
Kashiwagi
M
M
D000243:Adenosine Deaminase / Q000097:blood*; D000368:Aged; D001772:Blood Cell Count; D005260:Female; D005434:Flow Cytometry; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D016131:Lymphocyte Subsets / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*
D007527:Isoenzymes; D000243:Adenosine Deaminase