BCR-ABL rearrangement and 'variant' Philadelphia chromosome in de novo acute myelogenous leukaemia FAB subtype M1.
We report a case of de novo acute myelogenous leukaemia FAB subtype M1 that presents a cytogenetic complex translocation between chromosomes 7, 9 and 22, producing a 'variant' Philadelphia chromosome. Molecular analysis revealed a BCR-ABL rearrangement involving exons b3 and a2 (b3a2). Haematological parameters and genetic analysis again raise the problem of the true nature of this disease, which is briefly discussed.
Service of Genetics, Faculty of Medicine, University of La Laguna, Hospital N. Sra. La Candelaria, Tenerife, Spain.
J C
JC
Cigudosa
M T
MT
Acosta Almeida
V
V
Carrasco
T
T
Bello
J L
JL
Carrasco
A
A
Otero Gómez
J
J
Garcia Talavera
J L
JL
García Miranda
D000328:Adult; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D004587:Electrophoresis, Agar Gel; D005091:Exons; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D010677:Philadelphia Chromosome; D016133:Polymerase Chain Reaction
D016044:Fusion Proteins, bcr-abl