Yolk sac tumor in a case of testicular feminization syndrome.
A 17 month old who had been diagnosed as having testicular feminization syndrome (noted during inguinal herniorrhaphy) was operated on because of an abdominal mass that had a high serum level of alpha-fetoprotein. Histologically, the lesion was a yolk sac tumor. The alpha-fetoprotein level normalized within 2 months of the surgery, through the administration of adjunctive chemotherapy containing cisplatinum. The patient is disease-free 4 years postoperatively. When performing inguinal herniorrhaphy in a girl, the surgeon should be prepared to deal with testicular feminization syndrome. If gonadal neoplasm is deniable at the time of diagnosis, careful follow-up examinations are needed until completion of the development of secondary sex characteristics.
Department of Surgery, Fukuoka Municipal Children's Hospital, Japan.
N
N
Handa
A
A
Nagasaki
M
M
Tsunoda
H
H
Ohgami
T
T
Kawanami
K
K
Sueishi
M
M
Nagoshi
D013734:Androgen-Insensitivity Syndrome / Q000150:complications*; D018240:Endodermal Sinus Tumor / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013577:Syndrome; D013736:Testicular Neoplasms / Q000150:complications* / Q000601:surgery