The in vivo biological activity of ceramic fibres.
The well-known health effects following exposure to amphibole asbestos have led to some concern about the potential for other fibrous materials to cause similar diseases. This paper presents a summary of some of the inhalation experiments conducted with ceramic fibres in both rats and hamsters at the Research and Consulting Company, Geneva. One ceramic fibre (designated RCF1) was tested in rats at four exposure levels, this fibre was also tested in hamsters. Three other fibres were only tested in rats at the highest level--30 mg m-3. The increased incidence of tumours in these experiments has been contrasted with the negative results obtained with glass or mineral wools. However, there is evidence that the ceramic fibres were longer than the glass fibres and that long ceramic fibres were retained in lung tissue to a greater extent. This is sufficient to explain the results without recourse to explanations based on chemical differences between fibres.
MRC Toxicology Unit, University of Leicester, U.K.
R C
RC
Brown
J A
JA
Hoskins
L R
LR
Glass
D000336:Aerosols; D000538:Aluminum Silicates; D000818:Animals; D015197:Carcinogenicity Tests; D002516:Ceramics / Q000633:toxicity*; D006224:Cricetinae; D008175:Lung Neoplasms / Q000209:etiology*; D019016:Mineral Fibers / Q000633:toxicity; D051381:Rats; D013997:Time Factors
D000336:Aerosols; D000538:Aluminum Silicates; D019016:Mineral Fibers