[Bilateral femoro-popliteal acute recurrent arterial thrombosis in the course of heparin-induced thrombocytopenia (white thrombus syndrome)].
Heparin induced thrombocytopenia with thrombosis, or the "white clot syndrome" is a rare but very important complication of heparin therapy. The syndrome is idiosyncrasic, immune-mediated and not dose dependent and therefore is equally likely to occur with prophylactic and therapeutic heparin dosage regimens. We report a typical case of HIT that occurs with prophylactic heparin therapy and results in bilateral amputation of the lower limbs. We discuss this important condition and some guidelines on its prevention and treatment.
USL 13-Ascoli Piceno-Ospedale G.C. Mazzoni, Divisione di Chirurgia Generale I.
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Senati
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Barioglio
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Petrucci
D000208:Acute Disease; D000276:Adjuvants, Immunologic; D000671:Amputation, Surgical; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia; D007866:Leg / Q000098:blood supply / Q000601:surgery; D008875:Middle Aged; D010048:Ovarian Cysts / Q000601:surgery; D011150:Popliteal Artery / Q000601:surgery; D012008:Recurrence; D013577:Syndrome; D017131:Thrombectomy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D013927:Thrombosis / Q000209:etiology* / Q000276:immunology / Q000601:surgery
D000276:Adjuvants, Immunologic; D005338:Fibrin Fibrinogen Degradation Products; D006493:Heparin
Trombosi arteriosa acuta recidivante femoropoplitea bilaterale in corso di trombocitopenia indotta da eparina (sindrome da trombo bianco).