Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment.
Two cases of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis following treatment with propylthiouracil and carbimazole are described. Both patients had crescentic glomerulonephritis proven by renal biopsy and responded to immunosuppressive therapy and withdrawal of the anti-thyroid drugs. Though systemic vasculitis associated with propylthiouracil is reported, this is the first report to our knowledge of renal biopsy-proven vasculitis associated with either of these drugs.
Department of Rheumatology, St Bartholomew's Hospital, West Smithfield, London.
D
D
D'Cruz
A M
AM
Chesser
C
C
Lightowler
M
M
Comer
M J
MJ
Hurst
L R
LR
Baker
A E
AE
Raine
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D002231:Carbimazole / Q000009:adverse effects* / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D013971:Thyrotoxicosis / Q000188:drug therapy; D014657:Vasculitis / Q000139:chemically induced / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D001323:Autoantibodies; D011441:Propylthiouracil; D002231:Carbimazole