Immunoglobulin allotypes and RFLPs in disease association.
Immunoglobulin heavy chain (Gm) and light chain (Km) allotypes have been extensively studied as possible markers of susceptibility to a range of immune-related diseases including malignancies, infectious diseases and autoimmune disorders. This review is concentrated on susceptibility to multiple sclerosis, systemic lupus erythematosus and insulin-dependent diabetes mellitus.
Department of Applied Biology and Biotechnology, Royal Melbourne Institute of Technology, Vic., Australia.
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D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D005787:Gene Frequency; D005803:Genes, Immunoglobulin; D020022:Genetic Predisposition to Disease; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics* / Q000276:immunology; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology; D012150:Polymorphism, Restriction Fragment Length; D044469:Racial Groups / Q000235:genetics
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes; D007143:Immunoglobulin Heavy Chains