Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9.
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and RANTES are members of the beta chemokine family of leukocyte chemoattractants. We have previously cloned three mouse genes by cross-hybridization with the human MIP-1 alpha/RANTES receptor gene CMKBR1. One of the mouse genes, Scya3r, encodes a functional MIP-1 alpha receptor. The functions of the other two, Scya3r-rs1 and Scya3r-rs2, are not known. We have now mapped Scya3r, Scya3r-rs1, and Scya3r-rs2 to chromosome 9, in a region of conserved synteny with the location of CMKBR1. Thus, like chemokine genes and alpha chemokine receptor genes, this group of beta chemokine receptor genes arose by tandem duplication.
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
C A
CA
Kozak
J L
JL
Gao
P M
PM
Murphy
D000818:Animals; D001483:Base Sequence; D054407:Chemokine CCL4; D002874:Chromosome Mapping; D017124:Conserved Sequence; D003433:Crosses, Genetic; D016207:Cytokines / Q000235:genetics*; D006801:Humans; D019402:Macrophage Inflammatory Proteins; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D015846:Monokines / Q000235:genetics*; D005810:Multigene Family; D009115:Muridae / Q000235:genetics*; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000235:genetics*; D015183:Restriction Mapping
D054407:Chemokine CCL4; D016207:Cytokines; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; C080633:macrophage inflammatory protein 1alpha receptor