[Immunohistochemical study of radiation-induced apoptosis and oncogenes].
Relationships between radiation-induced apoptosis and oncogenes or suppressor genes (p53, MDM2, c-myc, p21ras and bcl-2) were immunohistochemically studied in 7 human tumors transplanted to nude mice. The most radiosensitive ependymoblastoma was negative for p53 and c-myc, however, the other 6 tumors were positive for them. Following irradiation, the ependymoblastoma became p53 positive, and showed the highest incidence of apoptosis among the 7 tumors. In addition, bcl-2 expression in this tumor was slightly different from that in the others.
Department of Radiology and Radiation Oncology, Gunma University, School of Medicine.
M
M
Hasegawa
M
M
Yamakawa
N
N
Mitsuhashi
M
M
Furuta
H
H
Sakurai
K
K
Hayakawa
H
H
Niibe
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects*; D016153:Genes, Suppressor / Q000528:radiation effects; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes / Q000528:radiation effects*