Influence of thyroid hormones on the regulation of growth hormone secretion.
The effects of thyroid hormones on GH secretion and the mechanisms underlying their action are very similar in man and the laboratory animal. We feel that it is possible to organize the available data into a unique pathophysiological model explaining these complex interactions (Table 1). In summary, physiological levels of circulating thyroid hormones are necessary to maintain normal pituitary GH secretion owing to their direct stimulatory actions. When the serum concentrations of thyroid hormone increase above the normal range there is an increase in hypothalamic somatostatin tone, which in turn suppresses pituitary GH secretion and overrides any stimulatory effects. The suppression of GH secretion by thyroid hormones may be mediated at the hypothalamic level also by a decrease in GHRH release.
Department of Internal Medicine, University of Brescia, Italy.
A
A
Giustina
W B
WB
Wehrenberg
D000818:Animals; D013006:Growth Hormone / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000032:analysis / Q000097:blood / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D010902:Pituitary Gland / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000032:analysis / Q000097:blood / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood / Q000502:physiology*
D013963:Thyroid Hormones; D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone