[The effect of human recombinant erythropoietin on levels of plasma phospholipids in patients chronically treated with hemodialysis].
In uremic patients a disturbed lipid metabolism is observed. In our former works a positive effect of erythropoietin (EPO) on blood platelet phospholipids composition in uremic patients was indicated. In this study we examined the EPO influence on blood plasma phospholipids in chronically hemodialyzed patients. Phospholipids were measured by thin layer chromatography method before and 3 months after the beginning of EPO treatment. EPO was administered subcutaneously, 2000 U twice a week. Decreased phosphatidylethanolamine, phosphatidylinositol and phosphatidylcholine levels were shown in patients before EPO treatment, compares with the control group. During EPO therapy the phospholipid levels approached to normal values. Conclusion is that EPO administration has a positive influence on blood plasma phospholipids in hemodialyzed patients. The detailed importance of this event has been not known yet, but our observations suggest that EPO profoundly interferes with lipid metabolism.
Oddziału Chorób Wewnetrznych Szpitala Wojewódzkiego, Chełmie.
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W
Krawczyk
A
A
Dmoszyńska
A
A
Ledwozyw
K
K
Marczewski
D000328:Adult; D004334:Drug Administration Schedule; D004921:Erythropoietin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D011994:Recombinant Proteins; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000628:therapy*
D010743:Phospholipids; D011994:Recombinant Proteins; D004921:Erythropoietin
Wpływ ludzkiej rekombinowanej erytropoetyny na stezenie fosfolipidów osocza u chorych przewlekle hemodializowanych.