Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome.
myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects.
Shetty
H U
HU
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Holloway
H W
HW
Acevedo
L D
LD
Galdzicki
Z
Z
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004171:Diploidy; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013402:Sugar Alcohols / Q000378:metabolism; D014314:Trisomy
D013402:Sugar Alcohols; D007294:Inositol