[The protective activity of the adhesion pili of Yersinia pestis].
Y. pestis adhesion pili (AP) in the native form and in the subunit form, used for immunization in one or two injections in a dose of 12-100 mu g on aluminum hydroxide, did not protect white mice and guinea pigs from experimental Y. pestis infection. The study revealed that AP produced a pronounced cytotoxic effect on macrophages and practically no influence on leukocytes. This result was confirmed in the study of luminol-dependent chemiluminescence and in the analysis of 5'-nucleotidase activity of phagocytes. These data make it possible to regard AP as Y. pestis antimacrophagal pathogenicity factor.
S O
SO
Vodop'ianov
A A
AA
Rybianets
L M
LM
Verkina
L V
LV
Romanova
T B
TB
Sorokina
B N
BN
Mishan'kin
D015720:5'-Nucleotidase / Q000032:analysis; D000818:Animals; D001422:Bacterial Adhesion; D003602:Cytotoxicity, Immunologic; D010861:Fimbriae, Bacterial / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D007962:Leukocytes / Q000201:enzymology / Q000276:immunology; D008163:Luminescent Measurements; D017737:Macrophages, Peritoneal / Q000201:enzymology / Q000276:immunology; D051379:Mice; D010930:Plague / Q000201:enzymology / Q000276:immunology / Q000517:prevention & control; D014774:Virulence; D015010:Yersinia pestis / Q000276:immunology* / Q000472:pathogenicity
D015720:5'-Nucleotidase
Izuchenie protektivnoĭ aktivnosti pileĭ adgezii Yersinia pestis.