[Cancer family syndrome in lung cancer--Li-Fraumeni syndrome in lung cancer].
A family with lung cancer family syndrome was reported with 5 persons of the Ist relatives, 3 of IInd relatives and one of IIIrd relatives, in whom one was synchronous, one asynchronous double cancers and one was in combination with lung cancer and renal cell carcinoma. Four surgical specimens were investigated in terms of p53 mutation by PCR-SSCR and also the analysis of ploidy pattern, AgNOR and PCNA. As a result, a special pattern of lung cancer family syndrome was not detected as compared with other lung cancer patients.
First Department of Surgery, Nagasaki University School of Medicine.
M
M
Tomita
Y
Y
Tagawa
T
T
Tsuji
H
H
Tsuji
H
H
Ayabe
D000328:Adult; D000368:Aged; D005192:Family Health; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D018095:Germ-Line Mutation; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged