[Significance of Staphylococcus aureus in nose operations. Risk of toxic shock syndrome?].
In a prospective clinical trial the pre- and postoperative presence of S. aureus was examined in 130 patients undergoing nasal septal surgery. The patients were randomized into three groups. The first group received no perioperative antibiotics, the second group was given oral amoxicillin plus clavulanic acid, while the third group was treated with oral sulfamethoxazol and trimethoprim. A significant decrease in the incidence of S. aureus was observed in post-operative cultures, but the difference was not attributable to the antibiotic use. Overall, 18.9% of the S. aureus carriers harbored toxic shock syndrome toxin-1 positive strains. However, the decrease in the presence of S. aureus and the risk for toxic shock syndrome was not influenced by the antibiotics administered. These findings show that the routine use of oral prophylactic antibiotics for patients undergoing nasal surgery seems not indicated.
Institut für Klinische Mikrobiologie und Immunologie, St. Gallen.
A
A
Pennekamp
P
P
Tschirky
R
R
Grossenbacher
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects; D019072:Antibiotic Prophylaxis; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000009:adverse effects; D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000382:microbiology / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D012225:Rhinoplasty; D012307:Risk Factors; D012772:Shock, Septic / Q000209:etiology / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
Bedeutung von Staphylococcus aureus bei Nasenoperationen. Gefahr des Toxic-shock-Syndroms?