Expression of lymphoid-associated antigens in mast cells: report of a case of systemic mast cell disease.
In this study the expression of 'classically' considered lymphoid-associated antigens (CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD19, CD20, and CD22) was explored both in peripheral blood (PB) and bone marrow (BM) mast cells (MC) in a case of systemic mast cell disease (SMCD) by means of using multiple stainings and a direct immunofluorescence technique. CD2 and CD22 were expressed in both PB and BM MC, all the remaining lymphoid-associated markers were negative. Our results suggest that the reactivity for both CD2 and CD22 in PB and BM MC would be aberrant.
Serviciío de Hematologia, Hospital Ramón y Cajal, Madrid, Spain.
L
L
Escribano
A
A
Orfao
J
J
Villarrubia
C
C
Cerveró
J L
JL
Velasco
F
F
Martín
J F
JF
San Miguel
J L
JL
Navarro
D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology*; D018801:CD2 Antigens / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D005434:Flow Cytometry; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D016130:Immunophenotyping; D037102:Lectins; D007946:Leukemia, Mast-Cell / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D051918:Sialic Acid Binding Ig-like Lectin 2
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D015415:Biomarkers; D018801:CD2 Antigens; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D037102:Lectins; D051918:Sialic Acid Binding Ig-like Lectin 2