[Cardiac transplantation; results after 5 years].
After cardiac transplantation, long-term results were assessed in a group of 46 patients who survived more than 5 years after surgery. They were the survivors (50%) of a group of 92 patients who underwent transplantation before January 1990. On January 1995, mean follow-up was 82 +/- 14 months. Quality of life was estimated satisfactory (mean score 8.4 +/- 2); 60% of the patients were active; 89% were class NYHA I or II. Nevertheless, several problems have been identified: rise in body weight for all, over 10 kg in 31%; hypertension, renal failure, considered to be severe (serum creatinine > 250 micrograms/l) in 26%, diabetes in 13%, osteoarthropathy in 33%, cancer in 6%, and, above all, chronic alteration of the coronary arterial bed in 53% of the patients. These problems reflect the immunological conflict and complications of immuno-suppression.
Loisance
D
D
Service de chirurgie thoracique et cardiovasculaire, hôpital Henri-Mondor, Créteil.
Mazzucotelli
J P
JP
Benvenuti
C
C
Le Besnerais
P
P
Mourtada
A
A
Aptecar
E
E
Pouillard
F
F
Deleuze
P H
PH
Hillion
M L
ML
Cachera
J P
JP
D000293:Adolescent; D000328:Adult; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000503:physiopathology; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011788:Quality of Life; D016896:Treatment Outcome
La transplantation cardiaque; résultats après 5 ans.