Metobromuron/metolachlor ingestion with late onset methemoglobinemia in a pregnant woman successfully treated with methylene blue.
Metobromuron, a substituted urea herbicide, is widely used for control of grasses and broad-leaved weeds in Taiwan. Major systemic toxicity has not been reported following poisoning. A 22-year-old woman at 36 weeks of gestation was admitted to the emergency department three hours after ingestion of a mixture of 25% metobromuron and 25% metolachlor. Though stable initially, she developed central cyanosis 12 hours later. Emergent cesarean section was considered but administration of intravenous methylene blue readily reversed the cyanosis and prevented the operation. Recurrent cyanosis did not develop. Normal vaginal delivery occurred 17 days after the poisoning. Follow-up for four years revealed normal growth of the child. Metobromuron poisoning, like other urea herbicides, may cause methemoglobinemia via its hydrolysis products. Administration of methylene blue is effective treatment and should be considered in the treatment of methemoglobinemia following urea herbicide poisoning.
Yang
C C
CC
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, R.O.C.
Hwang
S F
SF
Chou
M M
MM
Deng
J F
JF
D000081:Acetamides / Q000506:poisoning*; D000328:Adult; D003490:Cyanosis / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D008708:Methemoglobinemia / Q000139:chemically induced / Q000188:drug therapy*; D008751:Methylene Blue / Q000627:therapeutic use*; D010671:Phenylurea Compounds / Q000506:poisoning*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000188:drug therapy; D013405:Suicide
D000081:Acetamides; D006540:Herbicides; D010671:Phenylurea Compounds; C008770:metobromuron; D008751:Methylene Blue; C051786:metolachlor