Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion.
1. Lidocaine has been extensively investigated as a potential neuroprotective drug against ischemia-induced neurodegeneration without reaching any satisfactory conclusion. 2. The present work evaluates the effect of lidocaine -17 microM- on the hypoxia-induced release of tritiated D-aspartate from rat striatal slices in superfusion. 3. Hypoxia resulted in a significant increase in the amount of D-aspartate released from striatal slices preloaded with the tritiated excitatory amino acid analog. 4. The addition of lidocaine to the superfusion solution resulted in a drastic reduction in the amount of D-aspartate release evoked by hypoxia, rendering it close to normal values.
Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
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D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects*; D000860:Hypoxia; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009498:Neurotoxins; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D009498:Neurotoxins; D001224:Aspartic Acid; D008012:Lidocaine