Additional proof of reduction of ethanol absorption from rat intestine in vivo by high acetaldehyde concentrations.
We investigated intestinal ethanol absorption in rats pretreated with saline, cyanamide, 4-methylpyrazole and cyanamide + 4-methylpyrazole. The value of the absorption rate constant in the cyanamide-pretreated group with high acetaldehyde levels was the lowest among the four groups, but there were no significant differences among the remaining groups. We found that high acetaldehyde concentration itself clearly reduces intestinal ethanol absorption.
Department of Forensic Medicine, Kagawa Medical School, Japan.
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H
Kinoshita
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Ijiri
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S
Ameno
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C
Fuke
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K
Ameno
D000079:Acetaldehyde / Q000097:blood* / Q000378:metabolism; D000818:Animals; D003484:Cyanamide / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D000077604:Fomepizole; D007408:Intestinal Absorption / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D011720:Pyrazoles; D000431:Ethanol; D003484:Cyanamide; D000077604:Fomepizole; D000079:Acetaldehyde