Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder.
Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls. Neither prolactin nor cortisol response was different in SAD patients in comparison to controls. The reasons for discrepancy in findings between studies are discussed.
Nova Scotia Hospital, Dartmouth, NS, Canada.
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Yatham
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Michalon
D000328:Adult; D000375:Aging / Q000097:blood / Q000502:physiology; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology; D008875:Middle Aged; D015999:Multivariate Analysis; D011388:Prolactin / Q000097:blood*; D016574:Seasonal Affective Disorder / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D012701:Serotonin / Q000493:pharmacokinetics / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012727:Sex Characteristics; D011795:Surveys and Questionnaires
D005277:Fenfluramine; D006854:Hydrocortisone; D011388:Prolactin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors