Foamy virus vectors.
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
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Russell
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Miller
D016475:3T3 Cells; D000818:Animals; D001769:Blood; D016466:CHO Cells; D002455:Cell Division; D002460:Cell Line; D002461:Cell Line, Transformed; D002522:Chlorocebus aethiops; D006224:Cricetinae; D005822:Genetic Vectors; D016679:Genome, Viral; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics; D051379:Mice; D051381:Rats; D016092:Spumavirus / Q000235:genetics* / Q000254:growth & development; D014161:Transduction, Genetic; D014709:Vero Cells; D016662:Virus Integration