Molecular genetics of androgenic 17 beta-hydroxysteroid dehydrogenases.
17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) type 2 catalyzes the NAD(+)-dependent oxidation of androgens, estrogens and progestins, predominantly in the secretory endometrium, placenta, liver and small intestine. 17 beta-HSD type 3 catalyzes the NADPH-dependent conversion of androstenedione to testosterone in the testis, and the genetic disease 17 beta-HSD deficiency is caused by mutations in the 17 beta-HSD3 gene.
Andersson
S
S
Cecil H. & Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235-9051, USA.
D015067:17-Hydroxysteroid Dehydrogenases / Q000172:deficiency / Q000235:genetics*; D000728:Androgens / Q000096:biosynthesis*; D012734:Disorders of Sex Development / Q000235:genetics; D004717:Endometrium / Q000201:enzymology; D005260:Female; D005796:Genes; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008861:Microsomes / Q000201:enzymology; D010920:Placenta / Q000201:enzymology; D013737:Testis / Q000201:enzymology
D000728:Androgens; D007527:Isoenzymes; D015067:17-Hydroxysteroid Dehydrogenases