Ageing, oscillations and efficiency.
The phenomenon of ageing still defies understanding. Theoretical studies have indicated that glycolysis is more efficient at maintaining a high ATP/ADP ratio when oscillating at its resonant frequency. Earlier, it was proposed that the differentiated state results from the establishment of a stable pattern of temporal organisation. It is now suggested that ageing involves a decrease in efficiency due to the detuning of oscillating glycolysis as a result of frequency locking with other cellular oscillations in the differentiated state.
Gilbert
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DA
Department of Medical Biochemistry, Medical School, University of the Witwatersrand, South Africa.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009991:Oscillometry
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate