Efficacy of etofenprox against insecticide susceptible and resistant mosquito strains containing characterized resistance mechanisms.
Etofenprox is a non-ester pyrethroid insecticide with comparable toxicity and a similar mode of action to other pyrethroids. Cross-resistance studies on mosquitoes showed no effect of carboxylesterase, elevated esterase, altered acetylcholinesterase or glutathione S-transferase-based resistance mechanisms on etofenprox toxicity, when compared to standard susceptible strains of Anopheles and Culex. Cross-resistance to etofenprox occurred in a pyrethroid-resistant strain of Culex quinquefasciatus with both oxidase and 'kdr'-like resistance mechanisms. Dose-response data for susceptible mosquito strains suggest that, in standard W.H.O. susceptibility tests of adult mosquitoes, appropriate discriminating concentrations of etofenprox for detection of resistance would be 0.1% for Culex and 0.25% for Anopheles.
School of Pure and Applied Biology, College of Cardiff, University of Wales, U.K.
J
J
Hemingway
D000818:Animals; D000852:Anopheles; D003465:Culex; D007305:Insecticide Resistance; D007306:Insecticides; D009032:Mosquito Control; D011722:Pyrethrins
D007306:Insecticides; D011722:Pyrethrins; C076840:ethofenprox