Temporal changes in meal number and meal size relationship in response to rHu IL-1 alpha.
Peripherally infused interleukin-1 reduces food intake. Its temporal and selective effects on meal number and meal size were investigated in seven rats continuously infused for 3 days with recombinant human interleukin-1 alpha (rHu IL-1 alpha; 3 micrograms day-1, i.v.). Food intake decreased significantly during the first two infusion days, and was brought about by first the early reduction of meal number, followed by meal size with a 1 day delay. The primary effect of rHu IL-1 alpha was seen during the dark cycle. After the infusion was stopped, meal number recovered most quickly, followed by a lag in recovery of meal size. We conclude that rHu IL-1 alpha influenced food intake primarily via an effect on meal number, which responds more rapidly than a decrease in meal size, thereby inducing an immediate decrease in food intake.
Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210, USA.
D
D
Debonis
M M
MM
Meguid
A
A
Laviano
Z J
ZJ
Yang
J R
JR
Gleason
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003201:Computers; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011994:Recombinant Proteins / Q000494:pharmacology
D007375:Interleukin-1; D011994:Recombinant Proteins