The INS B allele (1,428 Fok I) is associated with reduced IDDM incidence in autoantibody-positive first degree relatives despite the presence of autoantibodies and high-risk HLA alleles.
Pugliese
A
A
Diabetes Research Institute, Miami, FL 33101, USA.
Awdeh
Z L
ZL
Alper
C A
CA
Jackson
R A
RA
Eisenbarth
G S
GS
D000483:Alleles; D001323:Autoantibodies / Q000097:blood / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology*; D005190:Family; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics*; D012307:Risk Factors
D001323:Autoantibodies; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D007328:Insulin