Effects of putative cognition enhancers on the NMDA receptor by [3H]MK801 binding.
Piracetam, aniracetam, and D-cycloserine were tested for their ability to reduce inhibition of [3H]MK801 (dizocilpine) binding by 100 microM kynurenate. Piracetam (100 microM-1 mM) failed to reduce inhibition by kynurenate but stimulated [3H]MK801 binding in the absence of kynurenate. In contrast, D-cycloserine (30 microM-1 mM) and aniracetam markedly reduced this inhibition by kynurenate. Thus, cognition enhancers might function via at least some subtypes of NMDA receptors.
Hamelin
S M
SM
Department of Neurosurgery, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19102-1192, USA.
Lehmann
J C
JC
D000818:Animals; D001667:Binding, Competitive; D003071:Cognition / Q000187:drug effects*; D003523:Cycloserine / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007736:Kynurenic Acid / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000187:drug effects*
D004338:Drug Combinations; D011760:Pyrrolidinones; D016194:Receptors, N-Methyl-D-Aspartate; C036466:aniracetam; D016291:Dizocilpine Maleate; D003523:Cycloserine; D007736:Kynurenic Acid; D010889:Piracetam