Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice.
It is generally believed that a smooth execution of a compound movement, or motor coordination, requires learning of component movements as well as experience-based refinement of the motor program as a whole. PKC gamma mutant mice display impaired motor coordination but intact eyeblink conditioning, a form of component movement learning. Cerebellar long-term depression, a putative cellular mechanism for component motor learning, is also unimpaired. Thus, PKC gamma mutant mice are defective in refinement of the motor program. In the accompanying paper, we demonstrate that innervation of multiple climbing fibers onto Purkinje cells persists in adulthood in these mutant mice. We propose that this defective elimination of surplus climbing fibers underlies motor discoordination.
Chen
C
C
Howard Hughes Medical Institute, Center for Learning and Memory, Cambridge, Massachusetts, USA.
Kano
M
M
Abeliovich
A
A
Chen
L
L
Bao
S
S
Kim
J J
JJ
Hashimoto
K
K
Thompson
R F
RF
Tonegawa
S
S
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000502:physiology; D003215:Conditioning, Eyelid / Q000502:physiology; D004594:Electrophysiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000235:genetics*; D017998:Leukotriene D4 / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D009043:Motor Activity / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000494:pharmacology; D011689:Purkinje Cells / Q000502:physiology / Q000648:ultrastructure; D013569:Synapses / Q000502:physiology
D015220:Calcium Channels; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D010446:Peptide Fragments; C072093:protein kinase C (19-36); D017998:Leukotriene D4; C087857:protein kinase C gamma; D011493:Protein Kinase C