Rich dynamics in a simplified excitable system.
The study aims at exploring effects of microscopic channel fluctuations on macroscopic dynamics of excitable systems. Molecular biology techniques are used in order to construct a minimal excitable system that is built of cloned channels embedded in a small (approximately 1 micron 2) isolated patch of membrane. This simple synthetic "point" system exhibits dynamics in time scales that are several orders of magnitude longer then a single spike.
Faculty of Medicine Rappaport Institute of Medical Science, Haifa, Israel.
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Marom
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Toib
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Braun
D000818:Animals; D001001:Anura; D002462:Cell Membrane / Q000502:physiology*; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D018408:Patch-Clamp Techniques
D007473:Ion Channels