Mivacurium chloride administration by infusion.
As a consequence of its rapid hydrolysis by plasma cholinesterase, mivacurium has a short duration of action, and recovery from neuromuscular blockade is rapid (5-95% twitch recovery = 13-15 min). Mivacurium is easy to titrate to individual patient requirements; the average infusion rate to maintain neuromuscular blockade at 89-99% twitch suppression during N2O/opioid anaesthesia is 6-7 micrograms/kg per min in adults and approximately 14 micrograms/kg per min in children. There is no evidence of a cumulative effect of mivacurium; recovery is unaffected by dose administered or duration of infusion. These characteristics make mivacurium a very suitable agent for use by infusion.
Department of Anesthesia and Critical Care, University of Chicago Hospitals, IL 60637, USA.
J L
JL
Apfelbaum
D000328:Adult; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D002648:Child; D002802:Cholinesterases / Q000097:blood; D006801:Humans; D006868:Hydrolysis; D007262:Infusions, Intravenous; D007546:Isoquinolines / Q000008:administration & dosage* / Q000378:metabolism; D000077590:Mivacurium; D009294:Narcotics / Q000008:administration & dosage; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage* / Q000378:metabolism; D009609:Nitrous Oxide / Q000008:administration & dosage; D013997:Time Factors
D018685:Anesthetics, Inhalation; D007546:Isoquinolines; D009294:Narcotics; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002802:Cholinesterases; D009609:Nitrous Oxide