A subclass of bHLH proteins required for cardiac morphogenesis.
Skeletal muscle development is controlled by a family of muscle-specific basic helix-loop-helix (bHLH) transcription factors. Two bHLH genes, dHAND and eHAND, have now been isolated that are expressed in the bilateral heart primordia and subsequently throughout the primitive tubular heart and its derivatives during chick and mouse embryogenesis. Incubation of stage 8 chick embryos with dHAND and eHAND antisense oligonucleotides revealed that either oligonucleotide alone had no effect on embryonic development, whereas together they arrested development at the looping heart tube stage. Thus, dHAND and eHAND may play redundant roles in the regulation of the morphogenetic events of vertebrate heart development.
Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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Srivastava
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Cserjesi
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Olson
D000199:Actins / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D002319:Cardiovascular System / Q000196:embryology / Q000378:metabolism; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D005314:Embryonic and Fetal Development; D015870:Gene Expression; D006321:Heart / Q000196:embryology*; D018257:Helix-Loop-Helix Motifs; D017403:In Situ Hybridization; D064326:MEF2 Transcription Factors; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009206:Myocardium / Q000378:metabolism; D018006:Myogenic Regulatory Factors; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D014157:Transcription Factors / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D029961:Zebrafish Proteins
D000199:Actins; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D064326:MEF2 Transcription Factors; D018006:Myogenic Regulatory Factors; D016376:Oligonucleotides, Antisense; D014157:Transcription Factors; D029961:Zebrafish Proteins; C095572:Hand1 protein, mouse; C498766:Hand2 protein, mouse; C578041:Mef2c protein, mouse; C410915:hand2 protein, zebrafish; C097341:helix-loop-helix protein, eHAND