[Recombinant human erythropoietin in the treatment of anemic patients undergoing chemotherapy for cancer].
Twenty-seven anemic patients with malignant tumour who received chemotherapy were treated with recombinant human erythropoietin (r-HuEPO). The objective of this study was to evaluate the effect of r-huEPO on hematologic and quality of life parameters as well as on transfusion requirement in patients with anemia secondary to cancer and cyclic chemotherapy. Patient population was allocated into two groups based on the chemotherapeutic regimens: 1. cisplatin containing and 2, non cisplatin containing regimen. Using 2 g/dl increase in haemoglobin levels as the criteria for response, twenty women responded to r-huEPO treatment. The response was more marked in the cisplatin group. R-huEPO treatment saved transfusion in both groups. Again, less patients required transfusion among those treated with cisplatin. There was a marked improvement in the quality of life which was more pronounced in patients who responded to r-huEPO treatment and in those receiving non cisplatin chemotherapy. No serious adverse experiences occurred. In conclusion, two third of patients with anemia secondary to cancer and cyclic chemotherapy can be effectively treated with r-huEPO. R-huEPO treatment invariably saves transfusion and is highly effective in improving quality of life. Adverse reaction is exceptional.
Szülészeti-Nögyógyászati Osztály. MAV Kórház, Budapest.
P
P
Bösze
A
A
Mayer
L
L
Thurzó
A
A
Kiss
K
K
Rák
J
J
Stumpf
D000740:Anemia / Q000188:drug therapy / Q000209:etiology*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001803:Blood Transfusion; D002945:Cisplatin / Q000627:therapeutic use; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007258:Informed Consent; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004921:Erythropoietin; D002945:Cisplatin
Kemoterápiában részesülö vérszegény daganatos betegek kezelése rekombináns humán erythropoetinnel.