[Probable coumarin poisoning upon ingestion of an anti-inflammatory agent].
Warfarin overdose leads to hypoprothrombinemia and bleeding diathesis. We report here the case of a 47 year old woman who ingested an overdose of a non-steroidal anti-inflammatory drug, sold in Mexico under the name of Wobenzym (R), and containing, according to the manufacturer: pancreatin, bromelin, papain, lipase, amylase, trypsin, alpha chymotrypsin and rutin. She developed skin, urinary and gastrointestinal bleeding and was found to be apparently under the effect of a coumadin overdose, i.e. prolonged prothrombin time, prolonged activated thromboplastin time, and low functional and antigenic levels of prothrombin. A platelet count, and the thrombin, reptilase and bleeding times were normal. All laboratory and clinical abnormalities reverted to normal by using fresh frozen plasma and parenteral vitamin K. In addition, we were able to show that the commercial preparation could prolong the prothrombin time in rabbits and, by high-performance liquid chromatography, a pike consonant with purified coumadin was found in the drug. It is concluded that this drug is probably contaminated by coumadin, and that physicians must be aware of its potential side effects.
Laboratorios Clínicos de Puebla, México.
J
J
Pérez-Jáuregui
A
A
Escate-Cavero
J
J
Vega-Galina
G J
GJ
Ruiz-Argüelles
G
G
Macip-Nieto
D000818:Animals; D001780:Blood Coagulation Tests; D002853:Chromatography, Liquid; D003374:Coumarins / Q000302:isolation & purification / Q000506:poisoning*; D004338:Drug Combinations; D004340:Drug Contamination; D062787:Drug Overdose; D005260:Female; D006474:Hemorrhagic Disorders / Q000139:chemically induced*; D006801:Humans; D006867:Hydrolases / Q000009:adverse effects* / Q000737:chemistry; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D008875:Middle Aged; D010936:Plant Extracts / Q000737:chemistry; D011817:Rabbits; D012431:Rutin / Q000009:adverse effects* / Q000737:chemistry; D012646:Self Administration
D003374:Coumarins; D004338:Drug Combinations; D010936:Plant Extracts; D012431:Rutin; C023295:Wobenzym; D006867:Hydrolases
Probable intoxicación por cumarínicos al ingerir un antiinflamatorio.