An unusual cytogenetic abnormality involving chromosomes 1 and 7 in a case of chronic myelomonocytic leukemia.
We report a case of chronic myelomonocytic leukemia in which cytogenetic analysis revealed a 47,XY, +1, +der(7)del(7)(q32q36)ins(7;1)(q32;p36.3p22) chromosomal constitution. This abnormal karyotype, which as a whole is new to any myeloid malignancy, points to a possible pathogenetic role for the oncogenes MET and FGR on the derivative chromosome 7, and for the CSF1 and JUN genes flanking the breakpoint on chromosome 1.
Papadhimitriou
S I
SI
Department of Clinical Hematology, Greek Cancer Institute, Athens, Greece.
Abazis
D
D
Repa
C
C
Papaconstantinou
C
C
Papanastasiou
C
C
Pangalos
C
C
Stamatelou
M
M
D000368:Aged; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D014314:Trisomy