[Comparative study of the efficacy and tolerance of 2 types of colon cleansing].
OBJECTIVE
To examine if (hypothesis): orally administered colon cleansing with 3 liters of balanced electrolyte/polyethylene glycol solution is superior to the standard method of bowel preparation with senna laxatives and sodium phosphate enemas.


METHODS
1st) Quality of colon cleansing estimated by the attending endoscopist. 2nd) Patient tolerance.


METHODS



METHODS
prospective randomized trial, blind to the endoscopist, comparing two methods of bowel preparation: group A received 3 L of the balanced electrolyte/polyethylene glycol solution the night before the procedure and group B was instructed to ingest 75 ml of a senna laxative the day before the colonoscopy and sodium phosphate enemas per rectum b.i.d. starting 2 days before the examination and again the morning of the procedure. Assessing criteria: 1st) Questionnaire filled by the attending endoscopist immediately after the completion of the colonoscopy. 2nd) Questionnaire filled by the patient the day after the procedure.


METHODS



METHODS
all the patients addressed to our Unit for colonoscopy (18 patients refused to participate).


METHODS
severe cardiovascular disease, decompensated diabetes mellitus and severe disease or neurological derangement that prevented collaboration (35 patients). Two hundred and sixteen patients were initially included, 110 in group A and 106 in group B; in 39 patients (18 in group A and 21 in group B) colonoscopy could not be completed for causes others than bowel preparation and were excluded for further evaluation by the endoscopist, thus, quality of bowel preparation was evaluated in 92 patients in group A and in 85 patients in group B; 83 patients (43 in group A and 40 in group B) did not answer the questionnaire, or did it incorrectly, thus, tolerance was evaluated in 67 patients in group A and in 66 patients in group B.


RESULTS
In 2 patients in group A (2.2%) and in 9 patients in group B (10.6%) colonoscopy could not be completed because of solid stool (p = 0.045). Mucosal visualization was better in group A than in group B (p = 0.0108). A total of 11.9% of the patients in group A and 25.8% of the patients in group B found the preparation hard or very hard to tolerate (p = 0.0001), patients in this latter group presented more frequently abdominal cramps (p = 0.0004), and distress (p < 0.00001), and dizziness (p = 0.0031). Bad tolerance in group B was primarily due to the rectal enemas (p < 0.0001).


CONCLUSIONS
Bowel preparation for colonoscopy with 3 L of orally administer balanced electrolyte/polyethylene glycol solution (PEG) results in a better colon cleansing and is better tolerated than the classical preparation consisting in oral purge and rectal enemas.
Hospital Santa María Nai, Servicio Galego de Saúde, Orense.
J
J
Fernández Seara
P
P
Pascual Rubín
M A
MA
Pato Rodríguez
J A
JA
Pereira Jorge
L M
LM
Domínguez Alvarez
E
E
Landeiro Aller
I
I
Tesouro Rodríguez
M C
MC
González Simón
M C
MC
Méndez Veloso
L
L
Peña Pérez
D003106:Colon; D003113:Colonoscopy; D004733:Enema; D005069:Evaluation Studies as Topic; D006801:Humans; D010710:Phosphates; D011092:Polyethylene Glycols; D011446:Prospective Studies; D012676:Senna Extract; D012996:Solutions; D013997:Time Factors
D010710:Phosphates; D012996:Solutions; D011092:Polyethylene Glycols; D012676:Senna Extract; C018279:sodium phosphate
Estudio comparativo de la eficacia y tolerancia de dos tipos de limpieza colónica.