Effects of acute 2,4-dichlorophenoxyacetic acid on cattle serum components and enzyme activities.
The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in cattle. Steers were dosed po with 100, 300 or 600 mg 2,4-D/kg bw. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), O-glutamyl transferase (O-GT), creatine kinase (CK), lactate dehydrogenase (LDH) activities and urea, creatinine, glucose, total proteins and albumin levels were determined at intervals after dosing. The lowest 2,4-D dose did not change the biochemical parameters studied; the 300 mg/kg dose decreased AST, O-GT and CK activities and increased urea and glucose levels; the highest dose of 2,4-D increased LDH and CK activities and protein, urea, creatinine and glucose levels. These changes were time and dose-dependent and completely reversible. Acute 2,4-D intoxication disrupted the serum levels of several enzymes and blood components which mainly reflect kidney and muscle damage induced by the herbicide.
Paulino
C A
CA
Research Center for Veterinary Toxicology (CEPTOX), School of Veterinary Medicine, University of Sao Paulo, Brazil.
Palermo-Neto
J
J
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D002417:Cattle / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009132:Muscles / Q000187:drug effects; D011897:Random Allocation; D013997:Time Factors; D014508:Urea / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D014508:Urea; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000469:Alkaline Phosphatase