Nimodipine increases CSF somatostatin in affectively ill patients.
Preliminary evidence suggests that nimodipine, an L-type calcium channel blocker, is effective in treating some patients with rapidly cycling affective disorders and some phases of Alzheimer's disease, i.e., two syndromes associated with transient or permanent reductions in cerebrospinal fluid (CSF) somatostatin, respectively. CSF somatostatin (SRIF) was measured in 14 affectively ill patients while they were medication-free and during chronic nimodipine treatment. CSF somatostatin significantly increased in patients during active nimodipine treatment compared with ones in the medication-free state. The current findings raise the possibility that nimodipine-induced increases in CSF somatostatin could potentially contribute to its spectrum of efficacy on neuropsychiatric disorders associated with cognitive or affective impairment. Further clinical and preclinical studies are indicated to elucidate the potential mechanisms involved in the elevation of CSF SRIF, whether it is reflected in regional changes in brain, and its possible relevance to nimodipine's clinical actions.
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892-1272, USA.
P J
PJ
Pazzaglia
M S
MS
George
R M
RM
Post
D R
DR
Rubinow
C L
CL
Davis
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy*; D009553:Nimodipine / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D013004:Somatostatin / Q000134:cerebrospinal fluid*
D002121:Calcium Channel Blockers; D013004:Somatostatin; D009553:Nimodipine