Association study of schizophrenia and the IL-2 receptor beta chain gene.
A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2R beta chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2R beta gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA.
V L
VL
Nimgaonkar
Z W
ZW
Yang
X R
XR
Zhang
J S
JS
Brar
A
A
Chakravarti
R
R
Ganguli
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D015375:Receptors, Interleukin-2 / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D044465:White People
D015375:Receptors, Interleukin-2