Low expression of adhesion molecules in a case of cutaneous T-cell lymphoma.
A case of cutaneous T-cell lymphoma (CTCL) with low expression of the adhesion molecules lymphocyte function-associated antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and very late antigen-4 (VLA-4) is described. The patient was a 90-year-old man with red round homogeneous tumors on his scalp, trunk, and extremities. He had no history of definite erythema or plaque stage. A biopsy sample taken from a tumor revealed massive infiltration of atypical lymphocytes in the reticular dermis and subcutis with a definite clear zone. The atypical lymphocytes were medium-sized with slightly convoluted nuclei. Immunohistochemically, the infiltrates showed the phenotype of so-called memory T cells. On the basis of these features, the case was diagnosed as CTCL. Expression of LFA-1, ICAM-1 and VLA-4 on the infiltrates was 9%, 13% and 11%, respectively, which is much lower than that in classic mycosis fungoides. This finding suggests that loss of these adhesion molecules may contribute to loss of epidermotropism in the advanced stage of CTCL.
Miyazawa
M
M
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Takahashi
S
S
Kawaguchi
H
H
Nagatani
T
T
Higuchi
M
M
Matsuzaki
T
T
Iemoto
G
G
Kim
S T
ST
Baba
N
N
Miyamoto
H
H
D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000032:analysis*; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D039001:Integrin alpha Chains; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D016029:Receptors, Very Late Antigen / Q000032:analysis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
C063493:CDw49d; D015815:Cell Adhesion Molecules; D039001:Integrin alpha Chains; D016169:Lymphocyte Function-Associated Antigen-1; D016029:Receptors, Very Late Antigen; D018799:Intercellular Adhesion Molecule-1