Localization of Epstein-Barr virus genome in lymphoid cells in poorly differentiated adenocarcinoma with lymphoid stroma of the colon.
Poorly differentiated adenocarcinoma with lymphoid stroma occurred in the transverse colon of a 77 year old female. Numerous small lymphocytes and plasma cells were distributed in the tumor stroma. Non-isotopic in situ hybridization study for Epstein-Barr (EBV)-related small nuclear RNA (EBER-1) revealed positive signals in the nuclei of a few lymphocytes in the tumor stroma, while the tumor cell nuclei were not labeled. Immunostaining for latent membrane protein-1 was negative. The significance of detection of the EBV-infected lymphocytes in the colon tumor stroma is discussed.
Vilor
M
M
Tsutsumi
Y
Y
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000821:virology*; D000368:Aged; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology / Q000821:virology*; D005260:Female; D016679:Genome, Viral; D006566:Herpesviridae Infections / Q000150:complications / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008214:Lymphocytes / Q000821:virology*