Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases.
We have cloned a novel human cDNA, INPPL1 (GenBank Accession No. L36818), which maps to 11q23. The corresponding mRNA is 4657 nt in length and is widely expressed in both fetal and adult tissues. An open reading frame of 3441 nt encodes a putative polypeptide that shares several domains with inositol triphosphate phosphatases. Several polymorphisms have been mapped to the 3'-untranslated region, yet the putative coding region showed no polymorphisms in nine independent cDNA samples.
Hejna
J A
JA
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
Saito
H
H
Merkens
L S
LS
Tittle
T V
TV
Jakobs
P M
PM
Whitney
M A
MA
Grompe
M
M
Friedberg
A S
AS
Moses
R E
RE
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018076:DNA, Complementary; D005333:Fetus; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010744:Phosphoric Monoester Hydrolases / Q000096:biosynthesis / Q000235:genetics*; D011110:Polymorphism, Genetic; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; C035215:inositol triphosphate phosphomonoesterase; D010744:Phosphoric Monoester Hydrolases