[The thrombocytic serotoninergic markers of the efficacy of electroconvulsive therapy in endogenous depressions].
The changes of main platelet serotonergic parameters (maximal velocity of 3H-serotonin uptake, Vmax; and density of (3)3H-imipramine binding sites, Bmax) were followed up in 25 endogenously depressed patients before and after electroconvulsive therapy (ECT). It was found a marked decrease in the velocity of 3H-serotonin uptake into platelets (Vmax) from patients before ECT (especially in non-responder group) and the significant increase of Vmax- and Bmax-values after the course of ECT in responders but not in resistant patients (non-responders). The increase of Vmax- and Bmax-values in responders was evidence of the rise of the functional activity serotonin system after treatment. The results evidence about the significance of serotonergic-mechanisms in the therapeutic efficacy of ECT.
Brusov
O S
OS
Dikaia
V I
VI
Gubergrits
I M
IM
Piatnitskiĭ
A N
AN
Zlobina
G P
GP
Faktor
M I
MI
Pavlova
O A
OA
Lideman
R R
RR
Panteleeva
G P
GP
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000628:therapy; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000097:blood* / Q000628:therapy*; D004565:Electroconvulsive Therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D011985:Receptors, Serotonin / Q000032:analysis / Q000378:metabolism*; D012074:Remission Induction; D012559:Schizophrenia / Q000097:blood / Q000628:therapy
D015415:Biomarkers; D011985:Receptors, Serotonin
Trombotsitarnye serotoninergicheskie markery éffektivnosti élektrosudorozhnoĭ terapii éndogennykh depressiĭ.