Mouse mast cell cytokine production: rôle in cutaneous inflammatory and immunological responses.
The rôle of mast cells in cutaneous physiology and pathology has long been a subject of intense speculation and great clinical interest. In this brief review, which is focused primarily on murine systems, we outline certain important aspects of the biology of the mast cell, including their ability to produce a variety of cytokines, describe the development of a model system (the "mast cell knock-in mouse") for studying the roles of cutaneous mast cells in biological responses in vivo, and illustrate a few examples of how this approach has been used to investigate the contributions of mast cells and their cytokines to cutaneous inflammatory or immune responses.
Department of Pathology, Beth Israel Hospital, Boston, MA 02215, USA.
S J
SJ
Galli
B K
BK
Wershil
D000818:Animals; D002455:Cell Division; D016207:Cytokines / Q000096:biosynthesis* / Q000187:drug effects; D007109:Immunity / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D012867:Skin / Q000166:cytology* / Q000187:drug effects; D012879:Skin Physiological Phenomena; D013373:Substance P / Q000494:pharmacology
D016207:Cytokines; D013373:Substance P