Rate of detection of human herpesvirus-6 at different stages of HIV infection.
In a cross-sectional study, human herpesvirus-6 (HHV-6) infection was analysed by means of polymerase chain reaction in peripheral blood mononuclear cells (PBMCs) and saliva from 125 HIV-seropositive subjects and 29 HIV-seronegative controls. HHV-6 was detected in saliva significantly more frequently in HIV-seronegative subjects than in HIV-seropositive subjects (p = 0.023), with no significant difference between HIV-seropositive subgroups. The HIV proviral copy number in PBMCs differed significantly according to HIV subgroup, as expected, but did not differ according to either the presence of HHV-6 or the number of HHV-6 copies in PBMCs. All the HHV-6 identified were variant B except for one variant A strain detected in saliva from a healthy subject. These results do not support the hypothesis that there is synergistic activation of HHV-6 infection in the course of HIV infection.
Laboratoire de Virologie, Centre National de Recherche Scientifique, CERVI, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
A
A
Gautheret
J T
JT
Aubin
V
V
Fauveau
W
W
Rozenbaum
J M
JM
Huraux
H
H
Agut
D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis; D015658:HIV Infections / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D012463:Saliva / Q000821:virology
D004279:DNA, Viral