Differential characteristics and localisation of [3H]oxazoline and [3H]imidazoline binding sites in rat kidney.
Comparative autoradiography revealed that the imidazolines [3H]p-aminoclonidine and [3H]idazoxan labelled high densities of alpha 2A-adrenoceptor sites in the inner medulla and inner stripe of the outer medulla of rat kidney. In contrast, the oxazoline [3H]rilmenidine labelled a high density of non-adrenergic sites in the cortex and outer stripe of the outer medulla, a lower density in the inner stripe and inner medulla and a low density of alpha 2A-adrenoceptor sites in inner medulla. The existence of novel, non-adrenergic oxazoline sites of potential functional importance in rat kidney has important implications for the classification of imidazoline receptors.
University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Vic., Australia.
P R
PR
King
S
S
Suzuki
W J
WJ
Louis
A L
AL
Gundlach
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D004146:Dioxanes / Q000494:pharmacology*; D019329:Idazoxan; D007093:Imidazoles / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D011921:Rats, Inbred WKY; D000077769:Rilmenidine
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D007093:Imidazoles; D010080:Oxazoles; D000077769:Rilmenidine; D019329:Idazoxan