Effects of VLDL, chylomicrons, and chylomicron remnants on platelet aggregability.
Although influences of cholesterol-rich lipoproteins on platelet aggregation are well established, the knowledge of interactions between triglyceride-rich lipoproteins and platelets, in particular in the postprandial state, is limited and controversial. The in-vitro effects of these lipoproteins from hypertriglyceridemic subjects on the aggregation behavior of platelets from normolipemic donors were investigated with two whole-blood methods. VLDL and chylomicrons, but not chylomicron remnants, in concentrations comparable to concentrations occurring after a fatty meal, reduced platelet aggregation in a dose-dependent manner in particle counting. Impedance aggregometry failed to monitor these effects. We conclude, that triglyceride-rich lipoproteins inhibit platelet aggregation in vitro. They may, therefore, not be linked to the acute onset of myocardial infarction.
Institute of Clinical Pathology and Clinical Biochemistry, Otto-von-Guericke-University, Magdeburg, Germany.
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Orth
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Luley
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Wieland
D000328:Adult; D002914:Chylomicrons / Q000502:physiology*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
D002914:Chylomicrons; D008079:Lipoproteins, VLDL; D014280:Triglycerides