Genetic heterogeneity study of non-syndromic autosomal recessive sensorineural deafness within the Tunisian population.
The number of loci for non-syndromic autosomal recessive sensorineural (N-SARS) deafness, was estimated within the Tunisian population and compared to that obtained in other populations. 30 deaf couples have been collected from 4 governorates (2,318,900 inhabitants) and 3 villages. Our investigations in these regions show that the percentage of congenitally deaf persons which marry each other is exceptionally low (10-30%). The number of loci for N-SARS deafness in the governorates sample was estimated at 8.3. Results could provide data for genetic counseling and facilitate our research concerning the localization of the different loci for N-SARS deafness present in Tunisian population.
Faculté de Pharmacie, Monastir, Tunisia.
H
H
Chaabani
S
S
Ben Arab
K
K
Chebbi
D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D004247:DNA / Q000032:analysis; D003638:Deafness / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D018740:Genetic Heterogeneity; D006801:Humans; D008297:Male; D013577:Syndrome; D014416:Tunisia / Q000453:epidemiology
D004247:DNA