Differential characteristics and localisation of [3H]oxazoline and [3H]imidazoline binding sites in rat kidney.
Comparative autoradiography revealed that the imidazolines [3H]p-aminoclonidine and [3H]idazoxan labelled high densities of alpha 2A-adrenoceptor sites in the inner medulla and inner stripe of the outer medulla of rat kidney. In contrast, the oxazoline [3H]rilmenidine labelled a high density of non-adrenergic sites in the cortex and outer stripe of the outer medulla, a lower density in the inner stripe and inner medulla and a low density of alpha 2A-adrenoceptor sites in inner medulla. The existence of novel, non-adrenergic oxazoline sites of potential functional importance in rat kidney has important implications for the classification of imidazoline receptors.
King
P R
PR
University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Vic., Australia.
Suzuki
S
S
Louis
W J
WJ
Gundlach
A L
AL
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D004146:Dioxanes / Q000494:pharmacology*; D019329:Idazoxan; D007093:Imidazoles / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D011921:Rats, Inbred WKY; D000077769:Rilmenidine
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D007093:Imidazoles; D010080:Oxazoles; D000077769:Rilmenidine; D019329:Idazoxan