Temporal bone findings in Alzheimer's disease.
Sensorineural hearing loss has been reported in Alzheimer's disease (AD) and a topographically specific pattern of degeneration in the central auditory system has been described. Although peripheral visual and olfactory systems have been extensively studied, there is no report of peripheral auditory system abnormalities in AD patients. Comparison of temporal bones from eight AD patients with those from eight non-AD controls revealed a significant difference in the percentage of remaining hair cells, peripheral processes, and spiral ganglion cells in the basal cochlear turn but no significant differences in the overall percentage between the two groups. Furthermore, special stains (thioflavin S and Bielschowsky's silver impregnation) of temporal bone nervous tissue from AD patients did not show neuritic plaques and neurofibrillary tangles. It is unclear whether the differences between the two groups in the basal portion of the cochlea are due to AD or some other process, such as presbycusis. However, lack of significant degeneration in other parts of the cochlea and absence of neurofibrillary tangles and neuritic plaques in all eight patients may suggest that the peripheral auditory system, unlike the peripheral visual and olfactory systems, is not involved in AD. A larger sample of AD patients is necessary to clarify the peripheral auditory system findings in the present study.
Department of Otolaryngology--Head and Neck Surgery, University of Southern California School of Medicine, USA.
U K
UK
Sinha
D
D
Saadat
F H
FH
Linthicum
K M
KM
Hollen
C A
CA
Miller
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001306:Auditory Pathways / Q000473:pathology*; D003051:Cochlea / Q000473:pathology; D004396:Coloring Agents; D005260:Female; D006198:Hair Cells, Auditory / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology; D013136:Spiral Ganglion / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology*
D004396:Coloring Agents