Effect of senegin-II on blood glucose in normal and NIDDM mice.
The hypoglycemic effect of senegin-II, the main component of Polygala senega (Polygalaceae), was examined in normal and KK-Ay mice, one of the model animals of non-insulin-dependent diabetes mellitus (NIDDM). Senegin-II (2.5 mg/kg) reduced the level of blood glucose in normal mice from 220 +/- 8 to 131 +/- 5 mg/dl 4 hours after intraperitoneal administration (P < 0.001), and also significantly lowered the blood glucose of KK-Ay mice from 434 +/- 9 to 142 +/- 6 mg/dl under similar conditions (P < 0.001).
Suzuka University of Medical Science and Technology, Japan.
M
M
Kako
T
T
Miura
M
M
Usami
Y
Y
Nishiyama
M
M
Ichimaru
M
M
Moriyasu
A
A
Kato
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004195:Disease Models, Animal; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry
D001786:Blood Glucose; D007004:Hypoglycemic Agents