Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production.
Immune responses dominated by interleukin-4 (IL-4)-producing T helper type 2 (TH2) cells or by interferon gamma (IFN-gamma)-producing T helper type 1 (TH1) cells express distinctive protection against infection with different pathogens. Interleukin-4 promotes the differentiation of naïve CD4+ T cells into IL-4 producers and suppresses their development into IFN-gamma producers. CD1-specific splenic CD4+NK1.1+ T cells, a numerically minor population, produced IL-4 promptly on in vivo stimulation. This T cell population was essential for the induction of IL-4-producing cells and for switching to immunoglobulin E, an IL-4-dependent event, in response to injection of antibodies to immunoglobulin D.
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.
T
T
Yoshimoto
A
A
Bendelac
C
C
Watson
J
J
Hu-Li
W E
WE
Paul
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D007073:Immunoglobulin E / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis; D007694:Killer Cells, Natural; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology; D018418:Th2 Cells / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D015847:Interleukin-4; D007073:Immunoglobulin E