Necrotizing sarcoid granulomatosis: computed tomography and pathologic findings.
OBJECTIVE
To describe the CT findings and corresponding pathological findings of necrotizing sarcoid granulomatosis (NSG).


METHODS
We reviewed the high-resolution CT and macroscopic and histologic findings in three pathologically proven cases of NSG.


RESULTS
The CT findings consisted of one case each with single nodule, multiple nodules, and parenchymal opacification. The abnormalities were peribronchovascular or subpleural in distribution. Histologically, all patients had sarcoid-like granulomas with central necrosis and granulomatous vasculitis. The CT findings correlated closely with the gross pathologic findings.


CONCLUSIONS
We conclude that the CT manifestations of NSG reflect the variable macroscopic pathologic findings.
Department of Radiology, University of British Columbia and Vancouver Hospital, Vancouver.
H
H
Niimi
T E
TE
Hartman
N L
NL
Müller
D000328:Adult; D005260:Female; D006099:Granuloma / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed