[Excretion of erythromycin, clindamycin and lincomycin into the saliva].
In rabbit experiments (n = 10) the salivary and serum levels of several antibiotics were studied after per os (clindamycin, erythromycin and lincomycin) and iv. (erythromycin) administration. Erythromycin was excreted into the saliva in a considerable degree (in 60-75% of the serum level) and displayed therapeutical levels for 5-6 hrs, whereas clindamycin and lincomycin reached in the saliva only 25-30% of the serum level and therapeutic levels were maintained only for 3 hours.
Debreceni Orvostudományi Egyetem, Stomatologiai Klinika, Debrecen.
B A
BA
Kelentey
B J
BJ
Kelentey
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002981:Clindamycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008034:Lincomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D012463:Saliva / Q000737:chemistry
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D008034:Lincomycin
Erythromycin, clindamycin és lincomycin nyálba történö kiválasztódásának vizsgálata.