[Serum hepatitis B markers: atypical patterns detected at the Hospital Insular de Gran Canaria].
Two atypical serological markers of hepatitis B virus (HBV) infection were detected in 19 patients during a 18-month period study. Pattern 1 (10 patients) was consistent with HBV-2 infection. Reactivity of HbsAG was confirmed by neutralization tests; the absence of other markers was also verified, included anti-HBcIgM. Three of the patients were classified in high risk groups and seven in the low risk groups for hepatitis B; in none of them was co-infection with hepatitis A virus (HAV) detected. Pattern 2 (9 patients) was characterized by the detection of HBsAg and HBeAg and the absence of other hepatitis B markers. Six of these patients were HIV-positive patients and had increased and persistent levels (for longer than 12 weeks) of these markers. In the three remaining patients (with no underlying immunological disorders) there was a loss of these markers within a variable time (2 days to 16 weeks). Nevertheless, DNA-VHB was detected in one of these serum samples once all markers of virus B had disappeared.
Servicio de Microbiología, Hospital Insular de Gran Canaria, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria.
O E
OE
Santana
A
A
Francés
A
A
Sierra
J
J
Hernández
A M
AM
Martín-Sánchez
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics; D006769:Hospitals, General; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain; D013997:Time Factors
D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
Marcadores serológicos de hepatitis B: patrones atípicos detectados en el Hospital Insular de Gran Canaria.