Effect of angiotensin converting enzyme inhibitor (captopril) on gastric ulcer production in pylorus ligated rats.
Intraperitoneal injection of Angiotensin Converting Enzyme inhibitor, captopril, reduced significantly (P < 0.001), the production of gastric ulcers in pylorus-ligated albino rats, compared to the control groups, irrespective of the dose schedule--single or quadruple. In the light of evidence available in the literature, it is reasonable to hypothesise that the anti-ulcer effect of captopril may be mediated through prostaglandins.
Department of Physiology, Kasturba Medical College, Manipal.
S P
SP
Rao
A
A
Sathiamoorthy
S S
SS
Sathiamoorthy
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002216:Captopril / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000897:Anti-Ulcer Agents; D002216:Captopril