[The role of enzymatic systems in pathophysiology and pharmacotherapy of Parkinson's disease].
In the metabolism of one of the main CNS neurotransmitters dopamine very important roles are played by four enzymes: two synthetizing dopamine: TH and DDC, and two enzymes breaking down dopamine: MAO-B and COMT. In a short review the author discusses disturbances of these enzymatic systems in parkinsonism and therapeutic possibilities of using drugs stimulating or inhibiting the activity of these systems.
Kuran
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Kliniki Diagnostyki i Terapii Chorób Układu Nerwowego, Instytutu Psychiatrii i Neurologii, Warszawie.
D001921:Brain / Q000201:enzymology* / Q000378:metabolism* / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000201:enzymology* / Q000503:physiopathology*
D008996:Monoamine Oxidase Inhibitors; D004298:Dopamine
Rola układów enzymatycznych w patofizjologii i farmakoterapii choroby Parkinsona.