Effect of repeated administrations of neomycin on the neuromuscular functions and the enhancement of d-tubocurarine action in mice.
Effects of repeated s.c. treatments with 50 mumol (approx. 31 mg)/kg/day of neomycin for 10 or 15 days were examined in mice. There were no significant differences between saline and neomycin treatment groups in the motor coordination assessed by rota-rod test and traction test. On tension recordings, an in vitro addition of d-tubocurarine inhibited the twitch tensions evoked by the nerve stimulations in both cases of saline or neomycin treatment. Neomycin treatments shifted the concentration-response curve between twitch tension and d-tubocurarine to the left, dependently on its injection days. These results suggest that repeated treatments with neomycin enhance the inhibitory effect of d-tubocurarine on the neuromuscular transmission in mice without eliciting motor incoordination and muscle relaxation.
Department of Toxicology, School of Veterinary Medicine, University of Osaka Prefecture, Japan.
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Tsusaki
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Nishimura
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Kurebe
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D004357:Drug Synergism; D004558:Electric Stimulation; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects; D009355:Neomycin / Q000008:administration & dosage / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018733:Nicotinic Antagonists / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009466:Neuromuscular Blocking Agents; D018733:Nicotinic Antagonists; D009355:Neomycin; D014403:Tubocurarine