Effect of amitriptyline on blood glucose level in rabbits.
Effect of single graded doses of amitriptyline (4, 8 and 16, mg/kg, p.o.) were observed on blood glucose level in 18 h fasted albino rabbits. All the doses of Amitriptyline produced significant hyperglycemia at 4 h, which attained a peak at 24 h with 16 mg/kg dose and appears to be due to blockade of the uptake of monominergic transmitters across the axoplasmic membrane, It (16 mg/kg) also produced glucose intolerance during early hours probably due to interference with gastrin function.
Department of Pharmacology, L. L. R. M. Medical College, Meerut.
B
B
Gupta
M K
MK
Shakarwal
A
A
Kumar
B P
BP
Jaju
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D011817:Rabbits
D000929:Antidepressive Agents, Tricyclic; D001786:Blood Glucose; D000639:Amitriptyline