Field trials of ephemeral fever vaccines.
Various bovine ephemeral fever (BEF) vaccines were tested between 1982 and 1984 in 24 Queensland herds; neutralising antibody responses were monitored and six of the herds were closely observed following natural challenge with ephemeral fever. A vaccine regime of two consecutive vaccinations with attenuated virus combined with the adjuvant Quil A provided excellent protection against BEF for at least 12 months, whereas one vaccination with the Quil A vaccine or two vaccinations with vaccine containing the adjuvant aluminium hydroxide gel did not provide significant protection. Antibody responses were highest for the vaccine incorporating Quil A when it was given as two consecutive injections. There was an apparent relationship between neutralising antibody response and the level of protection.
Department of Veterinary Pathology, University of Queensland, Brisbane, Australia.
B A
BA
Vanselow
J C
JC
Walthall
I
I
Abetz
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D000917:Antibody Formation; D002417:Cattle; D004810:Ephemeral Fever / Q000276:immunology* / Q000517:prevention & control; D018115:Ephemeral Fever Virus, Bovine / Q000276:immunology*; D007115:Immunization Schedule; D009500:Neutralization Tests; D011793:Queensland; D012449:Safety; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D014765:Viral Vaccines