Innovative approaches to gene therapy.
The past year has witnessed several advances in the development of targeted, cell-specific gene delivery systems of both viral and non-viral origin. Progress has been made in understanding the cellular mechanisms of nuclear import, and novel sequence-specific integrases have been developed that mediate insertion of DNA molecules into specific target sequences. Knowledge of the mechanisms by which herpes simplex virus and Epstein-Barr virus escape from immune surveillance has also advanced significantly; this may be exploited to reduce the immunogenicity of certain therapeutic gene products.
Therexsys Ltd. Keele, UK.
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Cunliffe
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Thatcher
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Craig
D000818:Animals; D001709:Biotechnology / Q000639:trends; D016503:Drug Delivery Systems / Q000639:trends; D015870:Gene Expression; D015316:Genetic Therapy / Q000639:trends*; D005822:Genetic Vectors; D006801:Humans; D007109:Immunity