Effects of a thromboxane synthase inhibitor (CS-518) on the eosinophil-dependent late asthmatic response and airway hyperresponsiveness in guinea pigs.
The effects of CS-518, a thromboxane A2 synthase inhibitor, on antigen-induced dual bronchial responses, airway hyperresponsiveness (AHR) and airway eosinophilia were investigated in an experimental guinea pig model of the late asthmatic response. Oral CS-518 (1 and 10 mg/kg) inhibited immediate and late asthmatic responses dose-dependently. It also inhibited AHR and eosinophil accumulation after antigen challenge. Therefore, thromboxane A2 is possibly involved in development of the late asthmatic response and AHR, and CS-518 was inferred to inhibit these via inhibition of eosinophil accumulation and thromboxane production.
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
K
K
Itoh
E
E
Takahashi
O
O
Mukaiyama
Y
Y
Satoh
T
T
Yamaguchi
D000818:Animals; D001249:Asthma / Q000209:etiology / Q000517:prevention & control*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000517:prevention & control*; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002634:Chemotaxis, Leukocyte; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D004804:Eosinophils / Q000276:immunology*; D006168:Guinea Pigs; D008297:Male; D016210:Methacholine Chloride; D010047:Ovalbumin / Q000276:immunology; D011657:Pulmonary Eosinophilia / Q000209:etiology / Q000517:prevention & control*; D013876:Thiophenes / Q000494:pharmacology* / Q000627:therapeutic use; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D013876:Thiophenes; D016210:Methacholine Chloride; C055806:RS 5186; D010047:Ovalbumin; D013930:Thromboxane-A Synthase