Effects of putative cognition enhancers on the NMDA receptor by [3H]MK801 binding.
Piracetam, aniracetam, and D-cycloserine were tested for their ability to reduce inhibition of [3H]MK801 (dizocilpine) binding by 100 microM kynurenate. Piracetam (100 microM-1 mM) failed to reduce inhibition by kynurenate but stimulated [3H]MK801 binding in the absence of kynurenate. In contrast, D-cycloserine (30 microM-1 mM) and aniracetam markedly reduced this inhibition by kynurenate. Thus, cognition enhancers might function via at least some subtypes of NMDA receptors.
Department of Neurosurgery, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19102-1192, USA.
S M
SM
Hamelin
J C
JC
Lehmann
D000818:Animals; D001667:Binding, Competitive; D003071:Cognition / Q000187:drug effects*; D003523:Cycloserine / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007736:Kynurenic Acid / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000187:drug effects*
D004338:Drug Combinations; D011760:Pyrrolidinones; D016194:Receptors, N-Methyl-D-Aspartate; C036466:aniracetam; D016291:Dizocilpine Maleate; D003523:Cycloserine; D007736:Kynurenic Acid; D010889:Piracetam