Review of azithromycin activity against Legionella spp.
Azithromycin is about as active against Legionella spp. in vitro as is erythromycin, with modal MICs approximately 0.5 to 0.125 microgram/ml, depending on the method used. In contrast, azithromycin is much more active against intracellular L. pneumophila than is erythromycin. In a guinea pig model of Legionnaires' disease, azithromycin is much more active than is erythromycin or clarithromycin. Despite the paucity of reports of treatment of Legionnaires' disease with azithromycin, it is likely to be as or more effective than erythromycin.
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
P H
PH
Edelstein
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017963:Azithromycin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007875:Legionella / Q000187:drug effects*; D016952:Legionella pneumophila / Q000187:drug effects*; D007877:Legionnaires' Disease / Q000188:drug therapy*; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D017963:Azithromycin