In vitro activity of trimethoprim in association with sulfimidazole against aerobic gram-negative and gram-positive microorganisms and Clostridia.
The in vitro activity of a chemotherapeutic agent, sulfimidazole (SIZ), obtained by combining two molecules belonging to groups of extremely different antibacterial drugs, p-aminobenzene sulfonamide and a derivative with a 5-nitroimidazole ring, was studied. In association with trimethoprim, SIZ induces an intense synergistic antibacterial effect on gram-negative and gram-positive aerobic microorganisms and Clostridia. The results show that, in SIZ, the activity of each starting molecule remains unchanged providing that its structure-action relationship is kept intact.
Castelli
M
M
Department of Biomedical Sciences, University of Modena, Italy.
Baggio
G
G
Ruberto
A I
AI
Rossi
T
T
Provvisionato
A
A
Malagoli
M
M
Bossa
R
R
Galatulas
I
I
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D066298:In Vitro Techniques; D009593:Nitroimidazoles / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009593:Nitroimidazoles; D013449:Sulfonamides; C061005:1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole; D014295:Trimethoprim