Non specific resistance against malaria pre-erythrocytic stages: involvement of acute phase proteins.
Levels of different acute phase proteins were compared in sera from parasitaemic and non-parasitaemic women living in a Plasmodium falciparum endemic area of Thailand. The ability of their sera to interfere with hepatic stage development of the parasite was examined. Correlations were found between levels of alpha-1 antitrypsin, alpha-2 macroglobulin, hemopexin and the potential of sera to block hepatocyte invasion by the sporozoite.
INSERM U 313, Groupe Pitié-Salpêtrière, Paris, France.
S
S
Pied
M D
MD
Tabone
G
G
Chatellier
M
M
Marussig
C
C
Jardel
F
F
Nosten
D
D
Mazier
D000209:Acute-Phase Proteins / Q000032:analysis / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008288:Malaria / Q000453:epidemiology / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010963:Plasmodium falciparum / Q000276:immunology; D010967:Plasmodium yoelii / Q000276:immunology; D013785:Thailand / Q000453:epidemiology
D000209:Acute-Phase Proteins; D000913:Antibodies, Protozoan