[Congenital and acquired cytomegalovirus infection in infants confirmed by virologic studies].
Sixty infants in whom clinical symptoms suspected of cytomegalovirus (CMV) infection were studied. CMV infection was found in 50% of the subjects. The diagnosis was based on studies of specific antibodies and isolation of the virus from urine and/or throat swabs. In most of the children the examinations were repeated several times, and clinical observations continued for 1 to 42 months (avg. 18 months). IgM-class antibodies were detected in 26 children and in 18 the virus was isolated. In 3 infants, isolation of CMV virus was the only evidence of active infection. Persisting viruria (avg. 11 months) and long-term presence of Ig G antibodies, even to 44th month of life were also observed. Congenital infection was diagnosed in 4 infants; the remaining ones acquired the infection during the perinatal period or later. In 7 cases transfused blood cannot be excluded as the source of infection. The clinical symptoms manifested in infected and non-infected children were similar. There was a statistically significant increase in the occurrence of hepatomegaly, splenomegaly, hyperbiliru-binemia and diarrhoea in infected children. Congenital abnormalities were found in 10 infected children, including 4 cases of congenital cytomegaly.
Zawilińska
B
B
Zakładu Wirusologii, Instytutu Mikrobiologii, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Kruszewska
M
M
Stopyrowa
J
J
Zgórniak-Nowosielska
I
I
D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis* / Q000821:virology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D008297:Male; D010614:Pharynx / Q000821:virology; D014556:Urine / Q000821:virology
D000914:Antibodies, Viral; D007075:Immunoglobulin M
Cytomegalia wrodzona i nabyta niemowlat potwierdzona badaniami wirusologicznymi.