Alzheimer's disease-type neurofibrillary degeneration in verrucose dysplasias of the cerebral cortex.
Verrucose dysplasias, found at autopsy in the cerebral cortex of three elderly individuals (two without neurological disorders and one with motor neuron disease), are shown to present neurofibrillary degeneration of Alzheimer's disease type. This neurofibrillary degeneration immunoreacted with antibodies against abnormally phosphorylated tau (5E2 and AT8), disclosed acetyl- and butyrylcholinesterase activity, and was consistently stained with thioflavin-S. Cortical dysplasias, found either as isolated verrucose nodules or comprising multiple nodules, contained cell-sparse areas around which a peak of neurofibrillary changes was seen. Cell-sparse areas were sometimes bridged by stripes of neurons and fibers arranged in a radial fashion, and many of these neurons showed neurofibrillary degeneration. Cytoskeletal abnormalities were conspicuous in layers II and III at the external borders of the dysplasias, as well as in neurons located in layers V and VI, and in the white matter beneath layer VI in central zones of each lesion. The morphology of cells undergoing neurofibrillary changes (from early non-fibrillar stages to late extracellular ones) suggests that neurons disturbed in their migration toward the site to which they had been committed may become vulnerable to cytoskeletal changes. Micro-environmental disturbances related to hypoxia-ischemia in the affected cortex are proposed as likely contributing factors for the long-term production of this neurofibrillary degeneration.
Department of Morphology, School of Medicine, Autonomous University of Madrid, Spain.
M A
MA
Morán
A
A
Probst
C
C
Navarro
P
P
Gómez-Ramos
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D052160:Benzothiazoles; D002540:Cerebral Cortex / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002802:Cholinesterases / Q000378:metabolism; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology; D016874:Neurofibrillary Tangles / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D013844:Thiazoles; D016707:Tissue Fixation; D016875:tau Proteins / Q000378:metabolism
D052160:Benzothiazoles; D005456:Fluorescent Dyes; D013844:Thiazoles; D016875:tau Proteins; C009462:thioflavin T; D002802:Cholinesterases