Dose-dependent effects of chronic amphetamine administration in local cerebral glucose utilization in rat.
The daily dose of amphetamine pretreatment may affect the development of behavioral-sensitized patterns in rodents and amphetamine psychosis in humans. This experiment investigated the regional cerebral metabolic changes in rats after pretreatment with different doses of amphetamine by the 2-[14C]deoxyglucose method. Rates of local cerebral glucose utilization were examined in 37 regions of the rat brain. The result showed generally maximal metabolic augmentation in the 5.0 mg/kg group instead of in the 1.0 or the 10.0 mg/kg groups. Behavioral testing using motor activity cages in rats with the same regimen found no difference among groups. The findings demonstrate that there might be a window effect by daily amphetamine dose on the development of drug dependence and amphetamine psychosis. It was suggested that the 2(-)[14C]deoxyglucose method could be used for further study of animal models of amphetamine psychosis.
Huang
Y H
YH
Institute and Department of Anatomy, National Yang-Ming University, Taiwan.
Tsai
S J
SJ
Yu
M F
MF
Wang
Y C
YC
Yang
Y C
YC
Sim
C B
CB
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D000661:Amphetamine; D005947:Glucose