Corneal perforation as a complication of epidermolysis bullosa acquisita.
Epidermolysis bullosa acquisita (EBA) is now recognised as a histopathologically distinct condition. Ocular complications of hereditary epidermolysis bullosa (EB) have been well documented, but little has been reported with respect to the ocular manifestations associated with the acquired form. A patient with EBA and sarcoidosis--an association that does not appear to have been previously reported--developed spontaneous peripheral corneal melting and perforation. The defect healed with the use of a bandage contact lens, antibiotics, mydriatics and pulsed intravenous steroids, and resulted in a satisfactory visual outcome.
Aclimandos
W A
WA
Eye Department, King's College Hospital, London, UK.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003316:Corneal Diseases / Q000150:complications* / Q000188:drug therapy; D016107:Epidermolysis Bullosa Acquisita / Q000150:complications*; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D009184:Mydriatics / Q000627:therapeutic use; D012422:Rupture, Spontaneous / Q000188:drug therapy; D012507:Sarcoidosis / Q000150:complications
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D009184:Mydriatics; D008775:Methylprednisolone