Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60.
4-[5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-methyldibenzo[b, e]diazepin-11-yl]benzoic acid (4) enhanced the differentiation-inducing activity of retinoic acid (1) and of a synthetic retinoid Am80 (2) toward human promyelocytic leukemia cells HL-60, although 4 alone did not induce differentiation. The synergistic effect of 4 on the activities of retinoids was also seen in suppression of proliferation of HL-60 cells.
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
H
H
Umemiya
E
E
Kawachi
H
H
Kagechika
H
H
Fukasawa
Y
Y
Hashimoto
K
K
Shudo
D002454:Cell Differentiation / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D018168:Receptors, Retinoic Acid; D014212:Tretinoin