Optical resolution of 1-arylethanols with a condensed aromatic ring by lipase from Pseudomonas aeruginosa.
Enantioselective syntheses of both enantiomers of 1-arylethanols with a condensed aromatic ring have been done through acetylation of the racemic alcohols with vinyl acetate in the presence of a lipase from Pseudomonas aeruginosa (Toyobo, LIP). The lipase LIP showed high enantioselectivity and reactivity for the title compounds, reacted acetates, and remaining alcohols were obtained with high optical purity.
Kato
K
K
Department of Chemistry, National Industrial Research Institute of Nagoya, Japan.
Katayama
M
M
Fujii
S
S
Kimoto
H
H
D000107:Acetylation; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000031:analogs & derivatives / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D013055:Spectrophotometry, Infrared
D000431:Ethanol; D008049:Lipase