Enhanced reactivation of nitrous acid treated adenovirus is not associated with enhanced mutagenesis in pretreated with heavy metals HeLa cells.
The reversion frequency of an adenovirus 2 temperature-sensitive growth mutant treated with different doses of nitrous acid was determined after infection of control. UV-irradiated, cadmium chloride and zinc chloride treated HeLa cells. No enhanced mutagenesis was observed.
Department of Biology, National Centre for Scientific Research Demokritos, Athens, Greece.
S M
SM
Piperakis
D000260:Adenoviruses, Human / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D002104:Cadmium / Q000633:toxicity; D019256:Cadmium Chloride; D002712:Chlorides / Q000633:toxicity; D004279:DNA, Viral / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D008670:Metals / Q000633:toxicity*; D008970:Molecular Weight; D016296:Mutagenesis; D009608:Nitrous Acid / Q000494:pharmacology*; D012044:Regression Analysis; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000187:drug effects / Q000528:radiation effects; D017967:Zinc Compounds / Q000633:toxicity
D002712:Chlorides; D004279:DNA, Viral; D008670:Metals; D017967:Zinc Compounds; D002104:Cadmium; C016837:zinc chloride; D019256:Cadmium Chloride; D009608:Nitrous Acid