[A patient with acute leukemia and meningitis caused by Staphylococcus epidermidis treated with fosfomycin].
In a 17-year-old male patient with acute lymphoblastic leukaemia, who was being treated with chemotherapy, a Staphylococcus epidermidis infection with several septicaemias developed during a period of protracted neutropenia. The patient was treated with vancomycin and fusidic acid, but blood cultures remained positive. The patient also developed staphylococcal meningitis. After the antibiotic regimen was supplemented by fosfomycin, the blood cultures became sterile. Combination treatment with vancomycin and fosfomycin was continued for two months without apparent toxicity. In individual cases of infection with multiresistant S. epidermidis fosfomycin may be included in the antibiotic regimen. This is the first report of parenteral use of fosfomycin in the Netherlands.
Afd. Inwendige Geneeskunde, Academisch Ziekenhuis Rotterdam-Dijkzigt.
M H
MH
Silbermann
I C
IC
Gyssens
J J
JJ
Wielenga
H P
HP
Endtz
B
B
Löwenberg
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005578:Fosfomycin / Q000008:administration & dosage; D005672:Fusidic Acid / Q000008:administration & dosage; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000382:microbiology*; D013212:Staphylococcus epidermidis; D014640:Vancomycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D005672:Fusidic Acid; D014640:Vancomycin
Een patiënt met acute leukemie en meningitis door Staphylococcus epidermidis behandeld met fosfomycine.