Recurrent dermatofibrosarcoma protuberans with myxoid and fibrosarcomatous changes paralleled by loss of CD34 expression.
A 38-year-old woman complained of recurrent nodules on her anterior chest wall. She noticed the first nodule at the age of 12 and has since undergone surgical removal a total of 31 times. Finally, wide resection of parts of the rib cartilage and sternum and chest wall reconstruction were required. Histopathological examination of a series of surgical specimens were reevaluated. Immunohistochemical staining of the tumors by anti-CD34 antibody provided a definite diagnosis of dermatofibrosarcoma protuberans (DFSP). A noteworthy result was that her DFSP did not always express CD34; the recurrent tumors with myxoid and fibrosarcomatous changes lost their CD34 expression.
Department of Dermatology, Akita University School of Medicine, Japan.
N
N
Sato
K
K
Kimura
Y
Y
Tomita
D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001706:Biopsy; D018223:Dermatofibrosarcoma / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery
D018952:Antigens, CD34