Combined superwarfarin and ethylene glycol ingestion. A unique case report with misleading clinical history.
A markedly elevated prothrombin time (PT) and activated partial thromboplastin time (APTT) were observed in a 24-year-old man who was admitted with a history of ethylene glycol ingestion. Further laboratory evaluation suggested that the coagulopathy was related to acquired factor deficiencies. The PT and APTT improved transiently on usual doses of vitamin K, but rapidly became abnormal again. The coagulopathy was controlled only after large doses of vitamin K for at least 37 days. On further questioning, the patient admitted to consuming a large quantity of a rodenticide. The second generation anticoagulant rodenticides (superwarfarins) result in a potent and prolonged anticoagulant effect by reducing the activity of the vitamin K dependent factors (II, XII, IX, and X). To our knowledge, this is the first reported concomitant ingestion of both ethylene glycol and a superwarfarin compound. This case serves to illustrate how a logical laboratory evaluation can lead to the proper diagnosis, despite a misleading clinical history.
Hennepin County Medical Center, Clinical Laboratories, Minneapolis, Minnesota 55415, USA.
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S
Seidelmann
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V
Kubic
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E
Burton
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L
Schmitz
D015110:4-Hydroxycoumarins / Q000008:administration & dosage / Q000506:poisoning*; D000328:Adult; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D006435:Renal Dialysis; D012378:Rodenticides / Q000008:administration & dosage / Q000506:poisoning*; D014812:Vitamin K / Q000627:therapeutic use
D015110:4-Hydroxycoumarins; D005026:Ethylene Glycols; D012378:Rodenticides; D014812:Vitamin K; C013418:bromfenacoum; D019855:Ethylene Glycol