Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation.
Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) have been observed after bone marrow transplantation (BMT), typically occurring 1-6 months following BMT. We describe two patients who developed TTP very early after BMT while receiving intravenous FK506. They were treated with platelet support and plasma exchange (PE) using either fresh frozen plasma (FFP) or cryosupernatant fraction of plasma (CFP), resulting in remission of TTP activity.
Gharpure
V S
VS
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Devine
S M
SM
Holland
H K
HK
Geller
R B
RB
O'Toole
K
K
Wingard
J R
JR
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000628:therapy; D016559:Tacrolimus / Q000009:adverse effects*
D016559:Tacrolimus