Primary and secondary orbital melanomas: a clinical and prognostic study.
The clinical, radiologic, and histologic features of 14 cases of orbital melanoma are reviewed. Two cases were presumed to be primary orbital melanomas because no primary pigmented lesion was found in the globe, conjunctiva, or skin. Five cases originated from a conjunctival melanoma, one case from an eyelid cutaneous melanoma, and the remaining six patients had extrascleral extension of a choroidal melanoma. Four patients at the time of first diagnosis already had extraorbital metastases (one patient with extrascleral extension of a choroidal melanoma also had a metastasis to the opposite orbit). The median time interval between diagnosis and metastasis was 14 months. Patients without metastatic disease received radical surgery (partial or total orbital exenteration, in addition to regional lymph node resection if indicated) or conservative treatment (tumor excision plus chemotherapy and interferon). Log-rank test showed an equally poor prognosis for both groups (median time to metastasis was, respectively, 19.5 and 8 months), with no statistically significant difference between the two groups. The authors' reconstructive techniques (dermis-fat grafting and transplantation of temporalis muscle) following partial- and total orbital exenteration are described.
Department of Ophthalmology and Neurosurgery, University of Siena, Italy.
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Polito
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Leccisotti
D000273:Adipose Tissue / Q000637:transplantation; D000328:Adult; D000368:Aged; D002830:Choroid Neoplasms / Q000473:pathology* / Q000601:surgery; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000601:surgery; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000637:transplantation; D009918:Orbital Neoplasms / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed