Enterovirus specific IgM responses in children with acute and chronic paralytic syndrome.
Enterovirus specific IgM responses in 51 children aged 0-7 years with acute, clinically diagnosed paralytic syndrome and 8 children with chronic paralysis were detected by IgM antibody capture enzyme immunoassay. Twenty-nine out of 51 (56.86%) acute phase sera were positive for enterovirus (Polio, CVB3 and CVA7) IgM antibodies, in 21 of whom poliovirus antibodies were found in close association with CVB3 and CVA7. On the other hand, preponderance of CVA7 specific IgM was detected in 6 out of 8 sera samples of chronically paralytic children.
Department of Microbiology, Defence Research and Development Establishment, Gwalior, India.
U
U
Tuteja
G
G
Pandya
R
R
Bharagava
D
D
Agarwal
A M
AM
Jana
D000208:Acute Disease; D000914:Antibodies, Viral / Q000096:biosynthesis; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003384:Coxsackievirus Infections / Q000276:immunology*; D004770:Enterovirus / Q000276:immunology*; D029822:Enterovirus B, Human / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007223:Infant; D010243:Paralysis / Q000276:immunology*; D011051:Poliomyelitis / Q000276:immunology*; D017955:Poliovirus / Q000276:immunology; D013577:Syndrome
D000914:Antibodies, Viral; D007075:Immunoglobulin M