[The efficacy of the emergency prophylactic and therapeutic actions of immunomodulators in experimental filovirus infections].
The study of the preventive and therapeutic action of some immunomodulators (ridostin, reaferon and polyribonate) used alone and in combinations was conducted on laboratory animals infected aerogenically by Marburg or Ebola virus. It was found that special preventive intranasal and intramuscular administration of ridostin provided protection of the animals infected by Marburg virus (p = 0.1) and an increase in their mean lifespan by 2.4 days (p = 0.15). In the Ebola infection combined administration of ridostin and reaferon caused an essential increase in the mean lifespan of the animals by 2.9 days (p = 0.04). None of the tested drugs had any significant positive effect when used in various combinations according to the treatment schemes in Marburg and Ebola infections in guinea pigs.
A N
AN
Sergeev
M Iu
MIu
Lub
O G
OG
P'iankova
L A
LA
Kotliarov
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000336:Aerosols; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control* / Q000635:transmission; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008379:Marburg Virus Disease / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control* / Q000635:transmission; D009930:Organic Chemicals; D012330:RNA, Double-Stranded / Q000627:therapeutic use; D012331:RNA, Fungal / Q000627:therapeutic use; D011994:Recombinant Proteins; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000336:Aerosols; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009930:Organic Chemicals; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D011994:Recombinant Proteins; C065320:polyribonate; C076741:ridostin
Effektivnost' ékstrenno-profilakticheskogo i lechebnogo deĭstviia immunomoduliatorov pri éksperimental'nykh filovirusnykh infektsiiakh.