Model studies of cellular excitation.
A mathematical model of the cardiac ventricular cell is used to describe ionic currents and dynamic concentration changes during a normal action potential. The model is also used to study arrhythmogenic activity of the single cell including early afterdepolarizations, delayed afterdepolarizations and rhythmic (spontaneous and triggered) activity under various degrees of calcium overload.
Rudy
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Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA.
D000200:Action Potentials; D000818:Animals; D006801:Humans; D017136:Ion Transport; D008962:Models, Theoretical; D009200:Myocardial Contraction / Q000502:physiology*; D016276:Ventricular Function