CD68+ reactive histiocytosis complicating early gastric cancer.
A peculiar form of reactive, non-granulomatous proliferation of CD68+ histiocytes was demonstrated, for the first time, in the submucosal layer just beneath the IIa-type early gastric adenocarcinoma that focally invaded submucosal lymphatics. The histiocytic cells possessed plump eosinophilic and often foamy cytoplasm and eccentric small nuclei with apparent nucleoli. They contained periodic acid-Schiff-reactive granules, and were further immunoreactive for lysozyme and alpha 1-antitrypsin. The infiltration was ill-defined, and partly involved the tunica muscularis mucosae and the proper muscle layer. Markers of epithelial cells, Langerhans' histiocytes, smooth muscle cells and myofibroblasts were all negative.
Ogawa
Y
Y
Inada
K
K
Tsutsumi
Y
Y
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006644:Histiocytes / Q000276:immunology* / Q000473:pathology; D015614:Histiocytosis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D010503:Periodic Acid-Schiff Reaction; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule