Heat stabilized, infectious poliovirus.
Polioviruses type 1 (Mahoney) and type 3 (Sabin) were treated with the antiviral pyridazinamine R78206 by first binding the compound to the virus and then removing unbound compound by dialysis. As a result of this treatment, both poliovirus strains were protected against thermal inactivation at 46 degrees C. The R78206 treatment did not cause inactivation except with the Sabin 3 strain at high R78206 concentrations.
Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
O
O
Ofori-Anyinam
R
R
Vrijsen
P
P
Kronenberger
A
A
Boeyé
D000998:Antiviral Agents / Q000494:pharmacology*; D006358:Hot Temperature; D010880:Piperidines / Q000494:pharmacology*; D017955:Poliovirus / Q000187:drug effects* / Q000472:pathogenicity; D011724:Pyridazines / Q000494:pharmacology*
D000998:Antiviral Agents; D010880:Piperidines; D011724:Pyridazines; C070921:R 78206