Experimental megaileum.
Typical megaileum occurred in young male Wistar rats three months after ileum myenteric plexus denervation. An average of 58.4% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in an 8 nm ring-shaped histological sectfrom the midportion of the treated segment. A morphometric study showed that the increased thickness of the megaileum wall was due to muscle hypertrophy and mucosal hyperplasia. The potential usefulness of this model of megaileum is emphasized.
Department of Morphology, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
S B
SB
Garcia
L Z
LZ
Pinto
S
S
Zucoloto
J S
JS
Oliveira
D000818:Animals; D001548:Benzalkonium Compounds / Q000633:toxicity; D003714:Denervation / Q000379:methods; D006965:Hyperplasia; D006984:Hypertrophy; D007077:Ileal Diseases / Q000209:etiology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology; D009197:Myenteric Plexus / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D001548:Benzalkonium Compounds