Tetrasomy 21 as a sole abnormality in erythroleukemia.
A 13-year-old girl presented with swelling in the neck, fever, bleeding of the gums, and hepatosplenomegaly. Bone marrow morphology was suggestive of erythroleukemia (AML-M6). Chromosome analysis of the marrow revealed 48,XX, +21, +21 as the sole clonal abnormality.
Udayakumar
A M
AM
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.
Sundareshan
T S
TS
D000293:Adolescent; D000782:Aneuploidy; D001853:Bone Marrow / Q000648:ultrastructure; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics* / Q000473:pathology