Recurrence and mortality in patients with differentiated thyroid carcinoma.
We examined the factors associated with increased recurrence and/or mortality of 195 patients with primary differentiated thyroid carcinoma. Of 171 patients who underwent at least, resection of the primary macroscopic tumor (curable), 26 patients (15%) developed recurrence and 6 of these patients died from the disease. Sixteen (67%) of 24 patients with initial distant metastasis or grossly malignant tumor residua in the neck after the operation (non-curable patients) died from the disease. In the curable patients, age, sex and tumor size correlated significantly with recurrence and/or mortality. When the characteristics of patients who died after recurrence were compared to those who survived after recurrence, however, only the patient's age correlated significantly with mortality. In the non-curable patients, the histologic subtype correlated significantly with mortality. It may be concluded, therefore, that the risk factors which affect mortality in differentiated thyroid cancer differ between curable and non-curable patients.
Noguchi
M
M
Department of Surgery, Kanazawa University Hospital, Japan.
Yagi
H
H
Earashi
M
M
Kinoshita
K
K
Miyazaki
I
I
Mizukami
Y
Y
D018263:Adenocarcinoma, Follicular / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D012307:Risk Factors; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy