Tissue plasminogen activator in the surgical excision of subfoveal choroidal neovascular membranes.
We investigated the use of tissue plasminogen activator (t-PA) as an adjunct to the surgical removal of subfoveal choroidal neovascular membranes. t-PA in a concentration of 6 micrograms/0.1 cc dissolved the fibrin rim surrounding recent subfoveal membranes but was less effective on more mature lesions. t-PA may be a useful intraoperative tool to limit the damage to surrounding structures during the surgical excision of recent subfoveal choroidal neovascular membranes with surrounding fibrin rims.
Thomas
J W
JW
Baylor College of Medicine, Houston, Texas 77030, USA.
Lopez
P F
PF
Lambert
H M
HM
D000328:Adult; D000368:Aged; D002462:Cell Membrane; D017024:Chemotherapy, Adjuvant; D002829:Choroid / Q000098:blood supply*; D005260:Female; D005342:Fibrinolysis; D005584:Fovea Centralis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000601:surgery*; D010960:Plasminogen Activators / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014792:Visual Acuity
D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator