Altered gene transcription following brief episodes of coronary occlusions.
This study was designed to elucidate whether previously observed enhanced mRNAs were due to accelerated transcription, enhanced mRNA stability or both mechanisms. We employed the nuclear run-on technique on myocardial nuclei and found the transcriptional induction of several genes, especially nuclear protooncogenes, Ca2+ regulating and heat shock protein genes.
Knöll
R
R
Max-Planck-Institute, Department of Experimental Cardiology, Bad Nauheim, F.R. Germany.
Zimmermann
R
R
Schaper
W
W
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003327:Coronary Disease / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D013552:Swine; D014158:Transcription, Genetic
D009687:Nuclear Proteins; D012333:RNA, Messenger