[The efficacy of the therapeutic and prophylactic actions of immunomodulators in experimental infection due to the causative agent of Venezuelan equine encephalomyelitis].
The investigation of the prevention and treatment action of some immunomodulators (ridostin, reaferon and polyribonate) used alone and in combinations was conducted on laboratory animals infected aerogenically by Venezuelan equine encephalitis (VEE) virus. A lower death rate of the aerogenically infected mice (10-30 respiratory LD50) was observed after intramuscular injection of ridostin. The preventive affect of ridostin and ridostin + reaferon administered intranasally and intramuscularly was achieved in the aerogenically infected guinea pigs (10 respiratory LD50). The results of the study on the early virus reproduction in the animals were used for the choice of the treatment scheme. The immunomodulators had no effect when the treatment was started 1 day after the VEE virus infection.
L E
LE
Bulychev
A N
AN
Sergeeva
A B
AB
Ryzhikov
L A
LA
Kotliarov
V D
VD
Poryvaev
I V
IV
Pliasunov
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000336:Aerosols; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004685:Encephalomyelitis, Venezuelan Equine / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control* / Q000635:transmission; D006168:Guinea Pigs; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D051379:Mice; D009930:Organic Chemicals; D012330:RNA, Double-Stranded / Q000627:therapeutic use; D012331:RNA, Fungal / Q000627:therapeutic use; D011994:Recombinant Proteins; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000336:Aerosols; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009930:Organic Chemicals; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D011994:Recombinant Proteins; C065320:polyribonate; C076741:ridostin
Effektivnost' lechebno-profilakticheskogo deĭstviia immunomoduliatorov pri éksperimental'noĭ infektsii, vyzvannoĭ vozbuditeliami venesuél'skogo éntsefalomielita loshadeĭ.