The lipooligosaccharides of Haemophilus ducreyi are highly sialylated.
The major lipooligosaccharides of the sexually transmitted pathogen Haemophilus ducreyi 35000 have been previously found to terminate in N-acetyllactosamine and sialyl-N-acetyllactosamine, Neu5Ac alpha 2-->3Gal beta 1-->4GlcNAc (W. Melaugh, N. J. Phillips, A. A. Campagnari, M. V. Tullius, and B. W. Gibson, Biochemistry 33: 13070-13078, 1994). In this study, mass spectrometry and composition analyses have shown that the lipooligosaccharides from three other H. ducreyi strains also contain N-acetyllactosamine and are highly sialylated (approximately 30 to 50%), although one African strain was found to contain neither of these structural features.
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.
W
W
Melaugh
A A
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Campagnari
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Gibson
D000606:Amino Sugars / Q000032:analysis; D002240:Carbohydrate Sequence; D006191:Haemophilus ducreyi / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D019158:N-Acetylneuraminic Acid; D009844:Oligosaccharides / Q000032:analysis; D012794:Sialic Acids / Q000032:analysis*
D000606:Amino Sugars; D008070:Lipopolysaccharides; D009844:Oligosaccharides; D012794:Sialic Acids; C023023:lipid-linked oligosaccharides; C000458:N-acetyllactosamine; D019158:N-Acetylneuraminic Acid