Effects of interleukin-1 beta and interleukin-2 on amino acids levels in mouse cortex and hippocampus.
We measured the levels of glutamine, aspartic acid, glutamic acid and GABA in cortex and hippocampus of mice acutely treated with i.p. human recombinant interleukin-2 (IL-2) or human recombinant interleukin-1 beta (IL-1 beta). Administration of IL-2 (5.0 micrograms kg-1) induced a slight but statistically significant increase in glutamine concentrations in both brain areas, while similar administration of IL-1 beta (20 micrograms kg-1) significantly reduced the hippocampal levels of glutamine, glutamic acid and GABA. Our data suggest that brain amino acid pathways are involved in the central modifications induced by IL-1 beta.
Bianchi
M
M
Department of Pharmacology, University of Milano, Italy.
Ferrario
P
P
Zonta
N
N
Panerai
A E
AE
D000596:Amino Acids / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D007375:Interleukin-1; D007376:Interleukin-2; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid