Involvement of 5-HT3 receptor in the pressure-induced increase in striatal and accumbens dopamine release and the occurrence of behavioral disorders in free-moving rats.
Rats exposed to high pressure developed locomotor and motor activity (LMA) that correlated with an increase of DA release in both the nucleus accumbens and the caudate-putamen. We investigated the effects of the 5-HT3 receptor antagonist MDL 72222 on these pressure-induced neurochemical and behavioral disorders. MDL 72222 totally blocked the pressure-induced increase in accumbens DA release and the development of LMA, whereas it only reduced the increase in striatal DA release. This suggest that both LMA and the increase of DA release in the nucleus accumbens, but not in the caudate-putamen, could specifically result from a 5-HT3 receptor activation in rats exposed to high pressure.
Laboratoire de Physiopathologie Respiratoire Intégrée et Cellulaire, CNRS-URA 1630, Institut Jean Roche, Faculté de Médecine, Marseille, France.
B
B
Kriem
J C
JC
Rostain
J H
JH
Abraini
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D004563:Electrochemistry; D006610:High Pressure Neurological Syndrome / Q000378:metabolism* / Q000523:psychology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009207:Myoclonus / Q000139:chemically induced; D017072:Neostriatum / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; C042253:bemesetron; D004298:Dopamine