Exacerbation of nickel induced oxidative response by vitamin E.
Vitamin E (alpha-tocopherol), a well known naturally occurring chain breaking antioxidant and a free radical scavenger was found to exacerbate nickel (Ni) toxicity in mice. Vitamin E (Vit. E) mediated enhancement of nickel toxicity was demonstrated by (i) enhanced mortality in mice treated with Ni and Vit. E (ii) increased hepatic lipid peroxidation, (iii) increased rate of benzoate hydroxylation, and (iv) liposomal membrane damage.
Industrial Toxicology Research Centre, Mahatma Gandhi Marg Lucknow, India.
M M
MM
Husain
N
N
Ahmad
S
S
Gupta
J R
JR
Behari
S K
SK
Hasan
S K
SK
Srivastava
R C
RC
Srivastava
D000818:Animals; D001565:Benzoates; D019817:Benzoic Acid; D004357:Drug Synergism; D005260:Female; D006801:Humans; D006900:Hydroxylation / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes; D051379:Mice; D008815:Mice, Inbred Strains; D009532:Nickel / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species; D014810:Vitamin E / Q000494:pharmacology*
D001565:Benzoates; D008081:Liposomes; D017382:Reactive Oxygen Species; D014810:Vitamin E; D009532:Nickel; D019817:Benzoic Acid