[The modification of Bacillus intermedius ribonuclease by urea derivatives].
The results of the "Bacillus intermedius" RNAase modification by urea derivatives are presented. The modifiers synthesized for that purpose were the following: N-(4-chlorbenzoyl)-N'-benzolsulfonyl urea (M1) and N-(4-chlorbenzoyl)carbomoyl-epsilon-aminocapronic acid (M2). It was shown that RNAase modified by M2 stimulated the cell general metabolism by the test of the cell absorption of neutral red and had a more marked ability to disrupt RNA of the cell plasmatic membranes in comparison to that of the native enzyme.
Kurinenko
B M
BM
Kalacheva
N V
NV
Fedotova
N R
NR
Bulgakova
R Sh
RSh
D000650:Amnion / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D001407:Bacillus / Q000201:enzymology*; D002478:Cells, Cultured; D006801:Humans; D007202:Indicators and Reagents; D009499:Neutral Red; D012313:RNA / Q000187:drug effects / Q000378:metabolism; D012260:Ribonucleases / Q000737:chemistry / Q000187:drug effects* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D007202:Indicators and Reagents; D009499:Neutral Red; D012313:RNA; D014508:Urea; D012260:Ribonucleases
Modifikatsiia ribonukleazy Bacillus intermedius proizvodnymi mochevin.