Foamy virus vectors.
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.
Russell
D W
DW
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
Miller
A D
AD
D016475:3T3 Cells; D000818:Animals; D001769:Blood; D016466:CHO Cells; D002455:Cell Division; D002460:Cell Line; D002461:Cell Line, Transformed; D002522:Chlorocebus aethiops; D006224:Cricetinae; D005822:Genetic Vectors; D016679:Genome, Viral; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics; D051379:Mice; D051381:Rats; D016092:Spumavirus / Q000235:genetics* / Q000254:growth & development; D014161:Transduction, Genetic; D014709:Vero Cells; D016662:Virus Integration