Stunned myocardium, an opinionated review.
Brief coronary occlusions cause stunning and ischemic preconditioning, the molecular mechanisms of which are insufficiently known. A marked reprogramming of sarcolemmal functions (including those of the sarcoplasmic reticulum) seems to occur and may be the basis for many of the observed phenomena. A bewilderingly complex pattern of gene expression emerges from mRNA-studies with reperfused tissue which at present does not permit a focussed or coherent view of mechanisms.
Schaper
W
W
W. G. Kerckhoff-Institut, Max-Planck-Institut für physiologische und klinische Forschung Abt. Experimentelle Kardiologie, Bad Nauheim.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009200:Myocardial Contraction; D017682:Myocardial Stunning / Q000503:physiopathology*
D002118:Calcium