Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.
Galli
J
J
Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Li
L S
LS
Glaser
A
A
Ostenson
C G
CG
Jiao
H
H
Fakhrai-Rad
H
H
Jacob
H J
HJ
Lander
E S
ES
Luthman
H
H
D000818:Animals; D001483:Base Sequence; D001835:Body Weight; D002874:Chromosome Mapping; D017931:DNA Primers / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004195:Disease Models, Animal; D005215:Fasting; D005260:Female; D008040:Genetic Linkage; D005947:Glucose / Q000378:metabolism; D006943:Hyperglycemia / Q000235:genetics; D007328:Insulin / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D011916:Rats, Inbred F344; D011922:Rats, Mutant Strains / Q000235:genetics*
D017931:DNA Primers; D007328:Insulin; D005947:Glucose