Leukaemia inhibitory factor prevents injury induced proliferation of striatal dopamine uptake sites.
The injury associated with implantation of an inert gelatin matrix (gel foam) into normal mouse striatum induces a long-lived increase in binding of [3H]mazindol to presynaptic dopamine uptake sites, probably due to proliferation of striatal dopaminergic terminals. Because of the known effects of leukaemia inhibitory factor (LIF) on catecholaminergic cells, we tested the hypothesis that LIF may alter the striatal dopaminergic response to injury in vivo. Application of LIF to mouse striatum in a gel foam implant abolished the usual injury induced proliferation of dopamine uptake sites. The ability of LIF to prevent proliferation of dopamine terminals may have important implications for our understanding of neural regeneration, the aetiology of Parkinson's disease and its treatment by intrastriatal grafting.
Howells
D W
DW
Department of Neurology, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.
Wong
J Y
JY
Churchyard
A J
AJ
Donnan
G A
GA
D000704:Analysis of Variance; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D005780:Gelatin; D006131:Growth Inhibitors / Q000627:therapeutic use*; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009411:Nerve Endings / Q000187:drug effects*; D010641:Phenotype; D019736:Prostheses and Implants; D013378:Substantia Nigra / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism
D018765:Dopamine Uptake Inhibitors; D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D008222:Lymphokines; D005780:Gelatin