Estrogen receptor immunoreactivity in ferret brain is regulated by estradiol in a region-specific manner.
The effects of estrogen on estrogen receptor (ER) immunoreactivity in the male ferret brain were examined. Estrogen treatment reduced the mean number of ER-immunopositive (ER+) cells/unit area in periventricular preoptic area but increased the mean number of ER+ cells/unit area in the medial division of the ventromedial hypothalamic nucleus, while having no effect on the number of ER+ cells/unit area in the lateral VMH and arcuate nucleus. Thus, estrogen regulates brain ER immunoreactivity in male ferrets and the direction and magnitude of this regulation are brain region-specific.
Sisk
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CL
Neuroscience Program, Michigan State University, East Lansing 48824, USA.
DonCarlos
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LL
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005289:Ferrets; D007150:Immunohistochemistry; D008297:Male; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen; D004958:Estradiol