Hexasomy of chromosome 8 and trisomy of chromosome 11 characterize two karyotypically independent clones in a case of acute non-lymphocytic leukemia. Conventional cytogenetic and FISH investigation.
A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics and FISH. Significant quantitative differences between data obtained by metaphase and interphase analysis of the hexasomy 8 clone were observed. A difference in the sensitivity to chemotherapy of the two clones was found: while the hexasomy 8 clone markedly decreased in response to treatment, the trisomy 11 clone remained unchanged.
Trakhtenbrot
L
L
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Rosner
E
E
Gipsh
N
N
Berman
S
S
Sofer
O
O
Brok-Simoni
F
F
Rechavi
G
G
Ben-Bassat
I
I
D000782:Aneuploidy; D001853:Bone Marrow / Q000648:ultrastructure; D002880:Chromosomes, Human, Pair 11; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy