Effect of sodium concentration in a carbohydrate-electrolyte solution on intestinal absorption.
Intestinal absorption during infusion (15 ml.min-1) of a 6% carbohydrate (2% glucose and 4% sucrose) solution containing either 0, 25 or 50 mEq.l-1 Na+ was measured by segmental perfusion with a triple lumen tube in males (age 24.3 +/- 1.6) at rest in a neutral environment (22 degrees C). Infusion of the 25 and 50 mEq.l-1 Na+ solutions was performed using a balanced design on the same day, separated by a 1-hr period of no infusion. Infusion of 0 mEq.l-1 Na+ solution was performed on a separate day. A 45-min equilibration period preceded a 90-min test session. Water and solute fluxes were determined from differences in concentration of polyethylene glycol and solute across a 40-cm intestinal segment of the duodenojejunum. A two-factor repeated measures ANOVA indicated no differences (P > 0.1) over time for water, Na+, or glucose flux for all solutions. Plasma volume increased (P < 0.01) approximately 5% over time for all solutions. We conclude that Na+ concentrations of 0, 25, or 50 mEq.l-1 in a 6% carbohydrate solution have similar effects on the absorption of water, Na+, and glucose from the duodenojejunum. Glucose in the infusion solution is the more important factor determining intestinal water absorption than Na+. This study suggests that adding Na+ to fluid replacement beverages may not be a factor in fluid absorption.
Department of Exercise Science and Internal Medicine, University of Iowa, Iowa City 52242, USA.
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Gisolfi
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Summers
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Schedl
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Bleiler
D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D004386:Duodenum / Q000378:metabolism; D004573:Electrolytes; D005440:Fluid Therapy; D005947:Glucose / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007441:Intubation, Gastrointestinal; D007583:Jejunum / Q000378:metabolism; D008297:Male; D009994:Osmolar Concentration; D014677:Pharmaceutical Vehicles; D010953:Plasma Volume; D011092:Polyethylene Glycols; D011188:Potassium / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D015532:Rehydration Solutions / Q000008:administration & dosage; D012964:Sodium / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D012996:Solutions; D013395:Sucrose / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D014867:Water / Q000378:metabolism
D001786:Blood Glucose; D004573:Electrolytes; D014677:Pharmaceutical Vehicles; D015532:Rehydration Solutions; D012996:Solutions; D014867:Water; D011092:Polyethylene Glycols; D013395:Sucrose; D012964:Sodium; D005947:Glucose; D011188:Potassium