Vascular complications of total abdominal perfusion and aortic stop-flow infusion.
During a 2 year period (1992-1993), 149 patients with advanced abdominal cancer underwent total abdominal ischemic perfusion (TAP) and stop-flow infusion (SFI) 159 times in an attempt to achieve palliation. These procedures and aortic stop-flow infusion require insertion of balloon catheters into the abdominal aorta and inferior vena cava by a transfemoral approach. Flow is arrested for 15 minutes, during which time chemotherapeutic agents are infused into the aorta, distal to the balloon occlusion. Femoral access is by a surgical incision. The passage of the catheters is guided by fluoroscopy. Some tumor response was observed in 35% of the patients. Ten patients had major vascular complications; two iliac artery aneurysms were lacerated and required emergency repair. There were two femoral artery false aneurysms that required surgical correction, one early and one late. Aortic dissection was detected in four patients, but these did not require surgical intervention. Two patients had thrombosis distal to the occluded vessel, both required surgical intervention. To reduce the incidence of these vascular complications we recommend: (1) a clinical and vascular laboratory evaluation before the procedure, and (2) angiography of normal flow in patients with underlying vascular disease.
Department of Surgical Oncology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
E S
ES
Klein
G Y
GY
Ben-Ari
M Z
MZ
Papa
R
R
Adar
A
A
Bass
D000008:Abdominal Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D000784:Aortic Dissection / Q000209:etiology*; D017541:Aneurysm, False / Q000209:etiology* / Q000601:surgery; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001011:Aorta; D001014:Aortic Aneurysm / Q000209:etiology*; D002404:Catheterization / Q000009:adverse effects* / Q000295:instrumentation; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007083:Iliac Artery / Q000293:injuries*; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008297:Male; D013927:Thrombosis / Q000209:etiology / Q000628:therapy
D000970:Antineoplastic Agents