Anti-liver membrane protein antibodies in dogs with chronic hepatitis.
Serum from 21 dogs with chronic hepatitis was evaluated for anti-liver membrane protein (anti-LMP) antibodies by an enzyme-linked immunosorbent assay. Ten of the 21 dogs had anti-LMP antibody concentrations greater than 2 SD above the mean value for the 10 healthy control dogs; titers ranged from 1:40 to greater than 1:1,600. Anti-LMP-positive dogs were not restricted by breed, had higher alanine amino transferase activity and total bilirubin concentration, and more severe liver lesions when compared with anti-LMP-negative dogs. This study provided evidence of humoral autoantibodies in dogs with chronic hepatitis, but it did not determine if the autoantibodies were primary or secondary.
Weiss
D J
DJ
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
Armstrong
P J
PJ
Mruthyunjaya
A
A
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001663:Bilirubin / Q000097:blood; D002462:Cell Membrane / Q000276:immunology; D002908:Chronic Disease; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006520:Hepatitis, Animal / Q000276:immunology*; D008099:Liver / Q000166:cytology / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*
D001323:Autoantibodies; D008565:Membrane Proteins; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin