Conjugates of glycosylated steroids and polyamines as novel nonviral gene delivery systems.
We have designed novel glycosteroid-polyamines for transmembrane DNA delivery based on amphiphilic drug transport agents. These glycosteroid-based agents show promise as viable DNA delivery technology for gene therapy.
Longley
C
C
Department of Biology, Transcell Technologies, Inc., Monmouth Junction, New Jersey 08852, USA.
Axelrod
H
H
Midha
S
S
Kakarla
R
R
Kogan
N
N
Sofia
M
M
Babu
S
S
Wierichs
L
L
Walker
S
S
D000818:Animals; D002461:Cell Line, Transformed; D002522:Chlorocebus aethiops; D004274:DNA, Recombinant / Q000008:administration & dosage* / Q000235:genetics; D004337:Drug Carriers; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D010714:Phosphatidylethanolamines / Q000008:administration & dosage; D011073:Polyamines; D013256:Steroids; D001616:beta-Galactosidase / Q000096:biosynthesis / Q000235:genetics
D004274:DNA, Recombinant; D004337:Drug Carriers; D010714:Phosphatidylethanolamines; D011073:Polyamines; D013256:Steroids; C020888:1,2-dielaidoylphosphatidylethanolamine; D001616:beta-Galactosidase