Influence of dextrans on cardiac preservation in an extracorporeal rat heart model.
Despite advances in preservation techniques for thoracic organs, the ischemic tolerance of the donor heart is still limited. Recently, a beneficial effect of oncotic substances such as dextran was shown in lung transplantation. Clinically, only in the University of Wisconsin (UW) solution oncotic substances for the prevention of cellular edema are used. Since little is known about the perspective value of dextrans in cardiac preservation, we investigated dextrans with different molecular weights added to the St. Thomas Hospital solution in an experimental working rat heart Langendorff model for functional and histological aspects. By comparison of various dextrans with molecular weights of 40,000, 70,000 and 160,000 daltons, best results were achieved by the addition of 5% dextran with the highest molecular weight.
Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany.
M
M
Albes
I
I
Baumgärtel
R
R
Rohde
B
B
Hausen
S
S
Demertzis
T
T
Wahlers
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D002314:Cardioplegic Solutions / Q000494:pharmacology; D003911:Dextrans / Q000737:chemistry / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008970:Molecular Weight; D009926:Organ Preservation; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000494:pharmacology
D001639:Bicarbonates; D002314:Cardioplegic Solutions; D003911:Dextrans; C041711:St. Thomas' Hospital cardioplegic solution; D012965:Sodium Chloride; D011189:Potassium Chloride; D008274:Magnesium; D002122:Calcium Chloride