Nutritional and metabolic considerations of the adult liver transplant candidate and organ donor.
Liver transplantation has progressed from an experimental procedure to an accepted treatment for end-stage liver disease. Yet, many potential recipients will die from infection, coagulopathy, or metabolic derangements before a donor liver becomes available. In addition, primary graft dysfunction after transplantation still represents a significant drain on professional resources. For these reasons, more attention is being directed toward identification of nutritional and metabolic factors in both the liver recipient and organ donor that can influence transplant outcome. The metabolic alterations present in these patients before and after liver transplantation require a more sophisticated approach to the provision of appropriate nutrition support. The goals of nutrition intervention for both the recipient and donor are to foster improved function of the allograft liver and to optimize eventual transplant outcome.
From the Department of Anesthesiology, Montefiore Medical Center and The Albert Einstein College of Medicine, Bronx, New York, USA.
D F
DF
Driscoll
J D
JD
Palombo
B R
BR
Bistrian
D000328:Adult; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology; D008107:Liver Diseases / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D016031:Liver Transplantation / Q000502:physiology / Q000592:standards*; D018529:Nutritional Support / Q000592:standards*; D011182:Postoperative Care; D011300:Preoperative Care; D014019:Tissue Donors; D014184:Transplantation, Homologous