The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination.
The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele ED gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E+ produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18.
Klungland
H
H
Department of Animal Science, Agricultural University of Norway, As, Norway.
Våge
D I
DI
Gomez-Raya
L
L
Adalsteinsson
S
S
Lien
S
S
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002874:Chromosome Mapping; D004247:DNA; D016368:Frameshift Mutation; D006200:Hair Color / Q000235:genetics / Q000502:physiology*; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length; D011979:Receptors, Pituitary Hormone / Q000235:genetics / Q000502:physiology*
D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D004247:DNA