Massive isotretinoin intoxication.
We report a case of acute intoxication due to a massive overdose of isotretinoin. A 29-year-old male patient ingested 900 mg of isotretinoin corresponding to 12.5 mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously, We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side-effects were mild and represented only exacerbations of some common isotretinoin side-effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotretinoin overdose.
Department of Dermatology, University Medical Center, Tours, France.
S
S
Aubin
G
G
Lorette
C
C
Muller
L
L
Vaillant
D000328:Adult; D062787:Drug Overdose; D006801:Humans; D015474:Isotretinoin / Q000506:poisoning*; D007641:Keratolytic Agents / Q000506:poisoning*; D008297:Male; D013406:Suicide, Attempted
D007641:Keratolytic Agents; D015474:Isotretinoin