Influence of the compliance of the pump housing and cannulas of a paracorporeal pneumatic ventricular assist device on transient pressure characteristics.
The dependence of transient pressure characteristics of a ventricular assist device (VAD) on the compliance of its housing and cannulas was investigated in a mock circulation. The peak rate of change of pressure (dP/dtmax) values was greater in the cannulas than other compartments and was associated with valve closure-induced pressure oscillations. When cannula compliance was increased from 0.0057 to 0.0129 cm3/mm Hg, these values decreased by approximately 20%, and outflow cannula pressure oscillation frequency decreased from 17.5 Hz by 35%. This trend was also apparent in the inflow. A VAD housing compliance increase from 0.0162 to 0.0483 cm3/mm Hg caused a dP/dtmax decrease of 30% in both the blood chamber and the outflow cannula. The effect of this change on the inflow was weaker implying that housing absorbs the energy associated with outflow deceleration more effectively than the inflow. These findings suggest that increasing VAD housing and cannulas compliance can improve hydrodynamic performance.
Heart Science Centre, National Heart and Lung Institute, Harefield Hospital, Middlesex, UK.
H
H
Ogino
N
N
Klangsuk
W
W
Jin
C T
CT
Bowles
M H
MH
Yacoub
D001672:Biocompatible Materials; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods*; D003187:Compliance; D006350:Heart Valve Prosthesis / Q000592:standards; D006351:Heart Valves / Q000502:physiology; D006353:Heart-Assist Devices / Q000592:standards* / Q000639:trends; D006801:Humans; D066298:In Vitro Techniques; D011140:Polyurethanes / Q000378:metabolism; D011312:Pressure
D001672:Biocompatible Materials; D011140:Polyurethanes