[The effect of norfloxacin on the luminol-dependent chemiluminescence and adhesion of leukocytes].
The in vitro effect of norfloxacin on the luminol-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied with the use of a wide range of the drug concentrations from 0.1 to 100 micrograms/ml under two different conditions, i.e. during the cell incubation in the presence of norfloxacin various concentrations and after the cell washing to remove the drug. In a concentration of 1 microgram/ml norfloxacin stimulated the zymosan-induced chemiluminescence. When the drug was used in a concentration of 10 micrograms/ml, the stimulating effect was less pronounced. In a concentration of 100 mu/ml norfloxacin significantly inhibited the leukocyte chemiluminescence. In concentrations of 0.1 to 100 micrograms/ml norfloxacin had no effect on the leukocyte adherence to the plastic surface covered by albumin.
A I
AI
Iordanova
T V
TV
Smolkina
A V
AV
Nikitin
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects*; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology*; D009643:Norfloxacin / Q000494:pharmacology*
D008165:Luminol; D009643:Norfloxacin
Vliianie norfloksatsina na liuminolzavisimuiu khemiliuminestsentsiiu i adgeziiu leĭkotsitov.