[Structure and function of P-glycoprotein in antitumor agent resistance; implication for clinical setting].
Resistance of tumors to a variety of chemotherapeutic agents presents a major problem in cancer treatment. The gene responsible for multidrug resistance, termed mdr1, encodes a membrane glycoprotein (P-glycoprotein) that acts as a pump to transport various cytotoxic agents. The P-glycoprotein has been shown to bind anticancer drugs and several resistance-reversing agents including calcium channel blockers, and to be an ATPase. The P-glycoprotein was found to function in blood-brain barrier. The implication of the P-glycoprotein in relation to therapy is discussed.
Institute of Molecular and Cellular Biosciences, University of Tokyo.
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D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000502:physiology*; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism; D001812:Blood-Brain Barrier; D002121:Calcium Channel Blockers / Q000378:metabolism; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D006801:Humans; D014700:Verapamil / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D014700:Verapamil