The H1-histamine receptor antagonist dithiaden inhibits stimulated platelet aggregation, malondialdehyde formation and thromboxane production in vitro.
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
R
R
Nosál
V
V
Jancinová
M
M
Petríková
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000818:Animals; D001582:Benzothiepins / Q000494:pharmacology*; D000001:Calcimycin / Q000037:antagonists & inhibitors; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013917:Thrombin / Q000037:antagonists & inhibitors; D013929:Thromboxane B2 / Q000096:biosynthesis*
D001582:Benzothiepins; D006634:Histamine H1 Antagonists; D010975:Platelet Aggregation Inhibitors; D000001:Calcimycin; D008315:Malondialdehyde; D013929:Thromboxane B2; C100170:dithiadene; D000244:Adenosine Diphosphate; D013917:Thrombin