Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells.
James
G L
GL
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Brown
M S
MS
Goldstein
J L
JL
D019883:Alkyl and Aryl Transferases; D000595:Amino Acid Sequence; D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D001921:Brain / Q000201:enzymology; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000032:analysis; D004926:Escherichia coli / Q000235:genetics; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D018411:Spodoptera; D014166:Transferases / Q000037:antagonists & inhibitors* / Q000235:genetics
D004791:Enzyme Inhibitors; D009842:Oligopeptides; D011994:Recombinant Proteins; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I