Disseminated epidermolytic acanthoma with disseminated superficial porokeratosis and verruca vulgaris in an immunosuppressed patient.
A 40-year-old man who had received long term immunosuppressive treatment for 14 years following kidney transplantation developed multiple skin lesions on both antecubital fossae, scalp, and both lower extremities. Histopathologic findings from three skin regions revealed characteristic features of epidermolytic hyperkeratosis, verruca vulgaris, and disseminated superficial porokeratosis, respectively. Although immunocompromised individuals may demonstrate verruca vulgaris or porokeratosis, disseminated epidermolytic acanthoma (DEA) has not been reported to be associated with immunosuppressed status. We suggest that immunosuppression may play a role in the pathogenesis of DEA, as shown in our case.
Chun
S I
SI
CHA General Hospital, Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Lee
J S
JS
Kim
N S
NS
Park
K D
KD
D000328:Adult; D004817:Epidermis / Q000473:pathology; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006965:Hyperplasia; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D017499:Porokeratosis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000276:immunology* / Q000473:pathology; D014860:Warts / Q000150:complications / Q000276:immunology* / Q000473:pathology