The nonspecific nature of endotoxin tolerance.
Re-exposure of organisms or cells to endotoxin after a previous challenge is not accompanied by the profound metabolic changes that are induced by the first encounter with endotoxin. Endotoxin tolerance is not specific to the action of lipopolysaccharide, and crossreactivity with other exogenous stimuli occurs. Various cytokines can mimic the effects of endotoxin in vivo and/or in vitro.
Unité d'Immuno-Allergie, Institut Pasteur, Paris, France.
J M
JM
Cavaillon
D000818:Animals; D016207:Cytokines / Q000276:immunology; D004731:Endotoxins / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D018448:Models, Immunological
D016207:Cytokines; D004731:Endotoxins