Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA-identical sisters.
We report three family members, including a set of identical twins, who developed CD5 positive B-CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related VH regions belonging to the VH3 subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.
Institute of Haematology, Sheba Medical Centre, Tel Hashomer, Israel.
I
I
Hakim
N
N
Amariglio
F
F
Brok-Simoni
M
M
Berkowitz
E
E
Rosner
A
A
Kneller
N
N
Hulu
B
B
Ramot
I
I
Ben-Bassat
G J
GJ
Silverman
D000368:Aged; D001483:Base Sequence; D018956:CD5 Antigens; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007557:Israel; D007585:Jews; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D008969:Molecular Sequence Data; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012306:Risk; D014430:Twins, Monozygotic
D018956:CD5 Antigens; D017931:DNA Primers; D006680:HLA Antigens