[Nasal smear cytology in bronchial asthma: correlation of appearance and numbers of nasal smear mast cells, eosinophils or basophils and serum IgE antibodies to house dust mite in patients with bronchial asthma].
Nasal smear cytology was studied in pediatric patients with bronchial asthma with special reference with IgE RAST to house dust mite, Dermatophagoides pteronyssinus (Dp). Results obtained were as follows: (1) Numbers of eosinophils on the nasal smear correlated well with Dp RAST score, (2) mast cells were detected before Dp RAST becoming positive and appearance of eosinophils, (3) basophils appeared after detection of eosinophils and only in patients with nasal smear eosinophils. These results suggest that mast cells are the early marker for allergic inflammation and basophils and eosinophils appear in association with overt sensitization with house dust mite in house dust mite-sensitized asthmatic patients.
Department of Pediatrics, School of Medicine, Chiba University.
K
K
Hirano
N
N
Shimojo
K
K
Saito
A
A
Hoshioka
T
T
Katsuki
K
K
Homma
Y
Y
Kohno
H
H
Niimi
D000293:Adolescent; D000818:Animals; D000918:Antibody Specificity; D001249:Asthma / Q000175:diagnosis*; D001491:Basophils; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003581:Cytodiagnosis; D004804:Eosinophils; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008407:Mast Cells; D008925:Mites / Q000276:immunology*; D009297:Nasal Mucosa / Q000166:cytology* / Q000276:immunology; D011852:Radioallergosorbent Test
D007073:Immunoglobulin E