Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency.
Cameron
C E
CE
Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106-4935, USA.
Burstein
H
H
Bizub-Bender
D
D
Ridky
T
T
Weber
I T
IT
Wlodawer
A
A
Skalka
A M
AM
Leis
J
J
D000595:Amino Acid Sequence; D016282:Aspartic Acid Endopeptidases / Q000737:chemistry* / Q000378:metabolism*; D001358:Avian Sarcoma Viruses / Q000201:enzymology*; D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D011994:Recombinant Proteins; D016282:Aspartic Acid Endopeptidases; D016333:HIV Protease; C072891:Rous sarcoma virus protease