Field trials of ephemeral fever vaccines.
Various bovine ephemeral fever (BEF) vaccines were tested between 1982 and 1984 in 24 Queensland herds; neutralising antibody responses were monitored and six of the herds were closely observed following natural challenge with ephemeral fever. A vaccine regime of two consecutive vaccinations with attenuated virus combined with the adjuvant Quil A provided excellent protection against BEF for at least 12 months, whereas one vaccination with the Quil A vaccine or two vaccinations with vaccine containing the adjuvant aluminium hydroxide gel did not provide significant protection. Antibody responses were highest for the vaccine incorporating Quil A when it was given as two consecutive injections. There was an apparent relationship between neutralising antibody response and the level of protection.
Vanselow
B A
BA
Department of Veterinary Pathology, University of Queensland, Brisbane, Australia.
Walthall
J C
JC
Abetz
I
I
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D000917:Antibody Formation; D002417:Cattle; D004810:Ephemeral Fever / Q000276:immunology* / Q000517:prevention & control; D018115:Ephemeral Fever Virus, Bovine / Q000276:immunology*; D007115:Immunization Schedule; D009500:Neutralization Tests; D011793:Queensland; D012449:Safety; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D014765:Viral Vaccines