Fluorescein labeling of tissue plasminogen activator for subretinal thrombolysis.
OBJECTIVE
To assess a technique that facilitated the use of tissue plasminogen activator in the dissolution and evacuation of subretinal blood.


METHODS
Fluorescein dye was added to the tissue plasminogen activator solution before subretinal injection.


RESULTS
Labeling tissue plasminogen activator solution with fluorescein made the solution easily visible, enhancing the ability of the surgeon to assess clot lavage, detect reflux into the vitreous cavity, and judge the extent of clot dissolution.


CONCLUSIONS
Adding fluorescein dye to tissue plasminogen activator solution is simple and gives the surgeon added control of clot lysis.
Department of Ophthalmology, W. K. Kellogg Eye Center, University of Michigan School of Medicine, Ann Arbor 48105, USA.
T E
TE
Schneiderman
M W
MW
Johnson
D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D019793:Fluorescein; D005452:Fluoresceins; D006406:Hematoma / Q000188:drug therapy*; D006801:Humans; D011184:Postoperative Period; D012166:Retinal Hemorrhage / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014792:Visual Acuity
D005343:Fibrinolytic Agents; D005452:Fluoresceins; D010959:Tissue Plasminogen Activator; D019793:Fluorescein