Functional brain imaging in HIV-1-infected children born to seropositive mothers.
The aim of this work was to study cerebral function in vertically infected children with human immunodeficiency virus 1 (HIV-1).


METHODS
PET with 18F-labeled fluorodeoxyglucose (FDG) was performed in eight children (2.5-5.5 yr): three with severe neurological symptoms and five without. Quantitative analysis was based on gray matter cortical and subcortical regions of interest for which glucose utilization was measured.


RESULTS
Diffuse hypometabolism and subcortical hypermetabolism were found in the three children with severe neurological signs; the five other children had temporo-occipital cortical hypometabolism, mainly on the right side.


CONCLUSIONS
Functional cerebral abnormalities seem to precede clinical symptoms in HIV-1infection of the brain in children.
Service Hospitalier Frédéric Joliot, CEA and INSERM U29, Orsay, France.
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Depas
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Chiron
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Tardieu
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Nuttin
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Blanche
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Raynaud
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A
Syrota
D015526:AIDS Dementia Complex / Q000000981:diagnostic imaging*; D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission; D001921:Brain / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D002675:Child, Preschool; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose