Peritoneal membrane failure in children on peritoneal dialysis.
Peritoneal dialysis (PD) success depends on adequate renal function replacement. Reports in adult dialysis populations indicate the risk of ultrafiltration failure (UF) increases with the time on dialysis. Type 1 UF is the most common. For children, dialysis modalities are temporizing measures until renal transplantation, considered optimal therapy for end-stage renal disease in children, can be performed. Children are frequently on dialysis for less than 2 years prior to transplantation. Thus if type 1 UF frequency increases with time on dialysis, it would be expected to occur less frequently in children, because they often are on dialysis for shorter periods. A retrospective chart review was performed to determine the cause of ultrafiltration failure in children; 172 children, mean age 8.0 +/- 5.5 (SD) years received a mean of 15 +/- 11.9 (SD) months of chronic PD; 39 patients received only continuous ambulatory peritoneal dialysis, 18 received only continuous cycling peritoneal dialysis, 22 received only tidal PD, and 94 received more than one type of PD. Ten patients (5.8%) developed type 2 UF failure as sequellae of atypical peritonitis, Candida albicans (6 patients), Mycobacterium foruitum (2), Achromatium spp. (1), and Pseudomonas aeruginosa (1). There was no significant difference in time on dialysis for children who developed membrane failure. No patients with type 1 or type 3 UF could be identified. It appears that the causes of peritoneal membrane failure in children are different from those in adults.
Department of Pediatrics, University of Florida College of Medicine, Gainesville, USA.
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Neiberger
D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010537:Peritoneum / Q000378:metabolism*; D010538:Peritonitis / Q000209:etiology; D010539:Permeability; D012189:Retrospective Studies