An unusual cytogenetic abnormality involving chromosomes 1 and 7 in a case of chronic myelomonocytic leukemia.
We report a case of chronic myelomonocytic leukemia in which cytogenetic analysis revealed a 47,XY, +1, +der(7)del(7)(q32q36)ins(7;1)(q32;p36.3p22) chromosomal constitution. This abnormal karyotype, which as a whole is new to any myeloid malignancy, points to a possible pathogenetic role for the oncogenes MET and FGR on the derivative chromosome 7, and for the CSF1 and JUN genes flanking the breakpoint on chromosome 1.
Department of Clinical Hematology, Greek Cancer Institute, Athens, Greece.
S I
SI
Papadhimitriou
D
D
Abazis
C
C
Repa
C
C
Papaconstantinou
C
C
Papanastasiou
C
C
Pangalos
M
M
Stamatelou
D000368:Aged; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D014314:Trisomy