Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues.
The Ber-ACT35 mAb was raised against the human T-cell lymphotrophic virus (HTLV) 1-transformed, CD4+ HUT 102 cell line and recognizes the human homologue of the OX40 (hOX40) antigen. The analysis of the expression of hOX40 by immunohistochemical techniques in malignant lymphomas, carcinomas and non-malignant tissues of different organs shows that hOX40 expression was almost completely restricted to T lymphocytes. Besides T cells only a small subpopulation of macrophages in Langerhans' cell histiocytosis and a few blasts in B-cell non-Hodgkin's lymphoma (B-NHL) revealed a faint immunostaining with the Ber-ACT35 mAb. Furthermore, most of the hOX40+ T-cells are CD4+.
Dürkop
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H
Institute of Pathology, Klinikum Benjamin Franklin, Free University of Berlin, Germany.
Latza
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U
Himmelreich
P
P
Stein
H
H
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002277:Carcinoma / Q000276:immunology; D002461:Cell Line, Transformed; D005434:Flow Cytometry; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins; D053278:OX40 Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*; D014018:Tissue Distribution
D008562:Membrane Glycoproteins; D053278:OX40 Ligand; D018124:Receptors, Tumor Necrosis Factor; C089251:TNFSF4 protein, human