In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.
The in vitro susceptibility of Mycobacterium leprae to levofloxacin was studied by using two biochemical parameters to measure the metabolic activity of the organism. Levofloxacin consistently exhibited twofold greater bactericidal activity than ofloxacin, with the MIC being 0.75 microgram/ml. When combined with one of the three rifamycin analogs, synergism was obtained with KRM-1648 and rifabutin but not with rifampin.
Dhople
A M
AM
Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901-6988, USA.
Ibanez
M A
MA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D003470:Culture Media; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000378:metabolism; D015242:Ofloxacin / Q000494:pharmacology*; D012294:Rifamycins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003470:Culture Media; D012294:Rifamycins; D064704:Levofloxacin; D000255:Adenosine Triphosphate; D015242:Ofloxacin; D013936:Thymidine