Molecular dynamics of HIV-1 protease in complex with a difluoroketone-containing inhibitor: implications for the catalytic mechanism.
Structural Biochemistry Program, PRI/Dyn Corp, NCI-Frederick Cancer Research and Development Center, Maryland 21702, USA.
A M
AM
Silva
R E
RE
Cachau
E T
ET
Baldwin
S
S
Gulnik
H L
HL
Sham
J W
JW
Erickson
D001665:Binding Sites; D002384:Catalysis; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology; D006801:Humans; D008782:Methylurea Compounds / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
C097457:A 79285; D017320:HIV Protease Inhibitors; D008782:Methylurea Compounds; D011725:Pyridines; D016333:HIV Protease