Acute renal failure after exercise in a child with renal hypouricemia.
We describe a 15 year old boy with renal hypouricemia who developed acute renal failure after a school athletics meeting, accompanied by appendicitis. During acute renal failure, the highest level of uric acid was 5.0 mg/dL, creatinine 7.9 mg/dL and urea nitrogen 58.6 mg/dL. After recovery, the serum uric acid fell to 0.9 mg/dL and the fractional excretion of uric acid (FEuA) exceeded the normal range. The probenecid and pyrazinamide tests showed that the patient had a total defect of uric acid reabsorption. This case suggested that strenuous exercise could be responsible for acute renal failure in patients with renal hypouricemia.
Fujieda
M
M
Department of Pediatrics, Kochi Medical School, Nanokoku-city, Japan.
Yokoyama
W
W
Oishi
N
N
Okada
T
T
Kurashige
T
T
Hamada
G
G
D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D001064:Appendicitis / Q000150:complications; D015444:Exercise; D006801:Humans; D008297:Male; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid