Steps toward gene therapy: 2. Cancer and AIDS.
Strategies under investigation--in some cases in clinical trials--include the delivery of "suicide genes" to induce the self-destruction of infected or tumorous cells and the delivery of genes to facilitate T-cell recognition of such cells. The HIV life cycle offers many additional attack points for therapeutic genes designed to prevent the expression of viral genes or to impede the function of essential HIV proteins.
Clinical Gene Therapy Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Md, USA.
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D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy*; D000818:Animals; D001932:Brain Neoplasms / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods; D005910:Glioma / Q000628:therapy*; D006678:HIV / Q000235:genetics; D006801:Humans