Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats.
Degree of renal damage in experimental untreated and treated hemorrhagic shock was estimated in light microscopy. Histological preparations were scored with a semiquantitative scale concerning the changes which are typical for the acute renal failure. It was found that an early treatment with the PAF-receptor antagonist (ginkgolide BN 52021) considerably reduced morphological changes observed in rat kidney in hemorrhagic shock, comparing with untreated shock and in shock treated with a polyelectrolyte solution.
Department of Pediatric Surgery, Medical Academy of Bialystok.
J K
JK
Kirejczyk
L
L
Chyczewski
W
W
Debek
D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004224:Diterpenes; D005260:Female; D046934:Ginkgolides; D007684:Kidney Tubules / Q000473:pathology; D007783:Lactones / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D012771:Shock, Hemorrhagic / Q000150:complications*
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; C045856:ginkgolide B