Experimental neonatal autoimmune myasthenia gravis: an immunohistochemical, ultrastructural and electrophysiological study of the motor end-plate.
Neonatal rats born of and nursed by mothers immunized with Narke japonica acetylcholine receptor protein had elevated serum anti-acetylcholine receptor antibodies that reached the mother's level on day 10 after delivery and decreased rapidly after weaning. IgG was present at the motor end-plates up to day 170, and the motor end-plate fine structure remained abnormal up to day 80. Miniature end-plate potential amplitudes in the diaphragm were at the control levels within 10 days of birth, but were lower than those of the controls up to day 80 after birth. We could not obtain the direct evidence that transient synthesis of antibodies occurs in experimental autoimmune myasthenia gravis pups. This model can serve as an experimental model of transient neonatal myasthenia gravis in humans, exception for the route of antibody transfer and the time of the onset of illness.
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
N
N
Tetsuo
M
M
Tsujihata
A
A
Satoh
T
T
Yoshimura
T
T
Nakamura
M
M
Seto
S
S
Nagataki
D000818:Animals; D000831:Animals, Newborn; D001327:Autoimmune Diseases / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D004555:Electric Fish; D004557:Electric Organ / Q000378:metabolism; D004594:Electrophysiology; D005260:Female; D007150:Immunohistochemistry; D008564:Membrane Potentials / Q000502:physiology; D009045:Motor Endplate / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure*; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009157:Myasthenia Gravis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D011233:Precipitin Tests; D051381:Rats; D011917:Rats, Inbred Lew; D011950:Receptors, Cholinergic / Q000378:metabolism; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure
D011950:Receptors, Cholinergic