New insights into peripheral T-cell lymphomas.
Peripheral T-cell lymphomas comprise a morphologically diverse group of malignant lymphoproliferative disorders that arise from postthymic T cells. Currently, there exists no universally accepted system of classification of peripheral T-cell lymphoma. Recent efforts to elucidate pathogenetic mechanisms and define recognizable entities have begun to clarify the nature of these tumors. These and future studies may one day lead to a unified system of classification of peripheral T-cell lymphoma that is reproducible, biologically relevant, and more predictive of clinical behavior and prognosis.
Beth Israel Hospital, Boston, Massachusetts, USA.
J F
JF
DeCoteau
M E
ME
Kadin
D002869:Chromosome Aberrations; D053804:Granzymes; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000096:biosynthesis
D009363:Neoplasm Proteins; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases