Haploidentical bone marrow transplantation from mother to child with advanced leukemia.
Use of the mother as mismatched marrow donor was assessed in 19 children with advanced leukemia. Patients were homogeneous for HLA incompatibility, age, donor, and conditioning regimen, and stage of disease. All received busulfan and cytoxan, combined with unmodified donor marrow, ALG given before and after transplant, and short MTX and cyclosporine as GVHD prophylaxis. Survival, LFS, and relapse respectively were 26, 26, and 33%. Incidence of overall and severe acute GVHD was 58 and 32%, respectively. Four patients had failure of engraftment, and two of these are alive with autologous reconstitution in complete remission. Probability of rejection was 21%. Results of haploidentical transplants were compared with those of children with advanced leukemia treated at the same institution, who received marrow from HLA-identical siblings. The probability of long-term leukemia-free survival was similar in the two groups. We thus propose using the mother as an alternative marrow donor in children with advanced leukemia.
Divisione di Ematologia e Centro Trapianto Midollo Osseo di Muraglia, Azienda Autonoma Ospedale San Salvatore di Pesaro, Italy.
P
P
Polchi
G
G
Lucarelli
M
M
Galimberti
C
C
Giardini
D
D
Baronciani
E
E
Angelucci
G
G
Sparaventi
D
D
Capponi
N
N
Talevi
M
M
Debiagi
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000628:therapy*; D008297:Male; D009035:Mothers; D012189:Retrospective Studies