Reduction by NG-nitro-L-arginine methyl ester (L-NAME) of antigen-induced nasal airway plasma extravasation in human subjects in vivo.
In non-allergic subjects, histamine induced a reduction of minimal nasal cross-sectional area (Amin) and an increase in albumin release into nasal lavage. The effect of histamine on albumin release was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), 1 mumol but not by D-NAME, 1 mumol. L-NAME, 1 and 10 mumol, did not inhibit the histamine-induced reduction of Amin. In subjects allergic to grass pollen, antigen challenge induced a reduction in Amin that was not changed by pretreatment with L-NAME, and an increase in albumin release that was inhibited by L-NAME, 1 mumol. The data support a role for nitric oxide in mediating plasma extravasation in the nose induced by antigen challenge or histamine.
Department of Pharmacology, University College London.
J W
JW
Dear
G K
GK
Scadding
J C
JC
Foreman
D000328:Adult; D000418:Albumins / Q000378:metabolism; D000941:Antigens / Q000276:immunology; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D019331:NG-Nitroarginine Methyl Ester; D009296:Nasal Cavity / Q000187:drug effects*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D012965:Sodium Chloride / Q000494:pharmacology
D000418:Albumins; D000941:Antigens; D004791:Enzyme Inhibitors; D012965:Sodium Chloride; D006632:Histamine; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester