Prevalence of autoantibodies in the very elderly: association with symptoms of ischemic heart disease.
The mechanisms leading to the increased expression of autoantibodies in the elderly are poorly understood. The aim of this study was to investigate whether the presence of ischemic heart disease (IHD) is associated with the prevalence of autoantibodies in the elderly over 85 years of age. Anti-nuclear (ANA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), thyroid anti-microsomal autoantibodies (anti-Tg) and antibodies to gastric parietal cells (PCA) were determined in selected groups of healthy subjects and patients with IHD. In IHD patients, the following autoantibodies were detected: ANA in 42.1% of subjects, SMA in 10.5%, AMA in 5.3%, anti-Tg in 5.3%, and PCA in 5.3%. In control healthy subjects, ANA were detected in 10%, AMA in 5%, and PCA in 15%. In conclusion, autoantibodies were more common in patients with IHD than in control healthy subjects, but no significant differences were found.
Department of Gerontology and Family Medicine, Collegium Medicum, Jagiellonian University, Cracow, Poland.
K
K
Potocka-Plazak
A
A
Pituch-Noworolska
J
J
Kocemba
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000276:immunology*; D012016:Reference Values
D001323:Autoantibodies