Quantitative structure-activity relationships and COMPACT analysis of a series of food mutagens.
Quantitative structure-activity relationships between chemical structure and Ames mutagenicity for a group of 24 food mutagens, including 17 cooked-food heterocyclic amines, have been determined. For the TA98 strain of Salmonella typhimurium (frameshift mutagens) the best correlation of mutagenicity is with molecular diameter (R = 0.91), while for the TA100 strain (base-pair mutations) the best correlation is with delta E, the energy difference between the lowest unoccupied and highest occupied molecular orbitals. High mutagenicity is related to high values of molecular diameter, hence to planarity and to high values of the COMPACT ratio ([area/depth2]/delta E). High mutagenicity is also related to low values of delta E. Consequently, highly mutagenic and potentially carcinogenic food chemicals can readily be identified as substrates of cytochrome P4501 (CYP1) and may therefore be detected by the COMPACT procedure. Highly mutagenic compounds also exhibit high values of dipole moment.
Lewis
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DF
School of Biological Sciences, University of Surrey, Guildford, UK.
Ioannides
C
C
Walker
R
R
Parke
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DV
D002273:Carcinogens / Q000032:analysis; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D012984:Software; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009153:Mutagens