The value of TPS in breast cancer.
The serum concentration of the cell proliferation marker TPS (Tissue Polypeptide-Specific Antigen) was compared with 7 different common tumor markers (CEA, CA 12-5, CA 19-9, CA 15-3, ferritin, AFP and beta 2-Microglobulin) in order to assess its practical value in the management of breast cancer. The new monoclonal TPS assay utilizing the specific epitope M3 is used to monitor cell multiplication in cancer patients. The values are not related to tumor burden but rather reflect the tumor proliferation rate. In our study no association was found between the TPS values and the age of the patients and histologic tumor types. Significant correlation was observed between the TPS values and the menopausal status of the patient. The regression analyses between TPS and the other markers did not reveal a correlation. Association between the TPS values and the CA 15-3 was not found. However, strong correlation between CA 15-3 and four other markers was observed. Therefore, it was concluded that TPS can provide additional information when used in combination with CA 15-3.
I.U. Oncology Institute, Department of Basic Oncology Istanbul, Turkey.
D
D
Karaloglu
V
V
Yasasever
N
N
Ertürk
N
N
Dalay
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D018396:Mucin-1; D010455:Peptides; C089984:tissue polypeptide specific antigen