Enzymuria in a population living near a cadmium battery plant.
OBJECTIVE
To study the body burden of cadmium and signs of tubular dysfunction in a rural population living near a closed nickel cadmium battery plant.


METHODS
Cadmium and N-acetyl-beta-glucosaminidase (NAG) in urine were measured in 72 subjects who lived close to the plant.


RESULTS
Residents living close to the plant had higher median urinary cadmium concentrations than those living farther away (1.01 v 0.46 nmol/mmol creatinine) and than a control group (0.2 nmol/mmol creatinine). There was a significant correlation between urinary cadmium and the excretion of NAG in urine as well as signs of tubular dysfunction in residents who excreted urinary cadmium above 0.5 nmol/mmol creatinine.


CONCLUSIONS
Tubular dysfunction may appear in environmentally exposed subjects at lower cadmium body burdens than previously anticipated.
Järup
L
L
Department of Environmental Health and Infectious Diseases Control, Karolinska Hospital, Stockholm, Sweden.
Carlsson
M D
MD
Elinder
C G
CG
Hellström
L
L
Persson
B
B
Schütz
A
A
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001822:Body Burden; D002104:Cadmium / Q000009:adverse effects* / Q000652:urine; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013548:Sweden
D002104:Cadmium; D000118:Acetylglucosaminidase