Anti-liver membrane protein antibodies in dogs with chronic hepatitis.
Serum from 21 dogs with chronic hepatitis was evaluated for anti-liver membrane protein (anti-LMP) antibodies by an enzyme-linked immunosorbent assay. Ten of the 21 dogs had anti-LMP antibody concentrations greater than 2 SD above the mean value for the 10 healthy control dogs; titers ranged from 1:40 to greater than 1:1,600. Anti-LMP-positive dogs were not restricted by breed, had higher alanine amino transferase activity and total bilirubin concentration, and more severe liver lesions when compared with anti-LMP-negative dogs. This study provided evidence of humoral autoantibodies in dogs with chronic hepatitis, but it did not determine if the autoantibodies were primary or secondary.
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
D J
DJ
Weiss
P J
PJ
Armstrong
A
A
Mruthyunjaya
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001663:Bilirubin / Q000097:blood; D002462:Cell Membrane / Q000276:immunology; D002908:Chronic Disease; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006520:Hepatitis, Animal / Q000276:immunology*; D008099:Liver / Q000166:cytology / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*
D001323:Autoantibodies; D008565:Membrane Proteins; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin