Effects of acute 2,4-dichlorophenoxyacetic acid on cattle serum components and enzyme activities.
The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in cattle. Steers were dosed po with 100, 300 or 600 mg 2,4-D/kg bw. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), O-glutamyl transferase (O-GT), creatine kinase (CK), lactate dehydrogenase (LDH) activities and urea, creatinine, glucose, total proteins and albumin levels were determined at intervals after dosing. The lowest 2,4-D dose did not change the biochemical parameters studied; the 300 mg/kg dose decreased AST, O-GT and CK activities and increased urea and glucose levels; the highest dose of 2,4-D increased LDH and CK activities and protein, urea, creatinine and glucose levels. These changes were time and dose-dependent and completely reversible. Acute 2,4-D intoxication disrupted the serum levels of several enzymes and blood components which mainly reflect kidney and muscle damage induced by the herbicide.
Research Center for Veterinary Toxicology (CEPTOX), School of Veterinary Medicine, University of Sao Paulo, Brazil.
C A
CA
Paulino
J
J
Palermo-Neto
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D002417:Cattle / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009132:Muscles / Q000187:drug effects; D011897:Random Allocation; D013997:Time Factors; D014508:Urea / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D014508:Urea; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000469:Alkaline Phosphatase