Localisation of a gene for chondrocalcinosis to chromosome 5p.
Chondrocalcinosis is a common disorder which may associate with acute and chronic arthritis. A familial form, inherited as an autosomal dominant trait, has been mapped in a large family in which affected members also suffer recurrent fits in childhood. The gene which causes this disease shows linkage with several polymorphic markers on chromosome 5p with a maximum multipoint lod score of 4.6 between D5S810 and D5S416. Mapping a locus for chondrocalcinosis will allow the heterogeneity of the disorder to be assessed and may also be relevant to understanding the aetiology of osteoarthritis with which it commonly associates.
Hughes
A E
AE
Department of Medical Genetics, Queen's University of Belfast, UK.
McGibbon
D
D
Woodward
E
E
Dixey
J
J
Doherty
M
M
D002648:Child; D002805:Chondrocalcinosis / Q000209:etiology / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic