Combination treatment with cisplatin and schizophyllan for 7,12-dimethylbenz(a)anthracene-induced rat ovarian adenocarcinoma.
OBJECTIVE
Experimental chemotherapy was conducted to investigate the combined effect of Schizophyllan (SPG) and Cisplatin (CDDP).


METHODS
Rats with 7,12-dimethylbenz(a)anthracene (DMBA)-induced ovarian adenocarcinoma received SPG and/or CDDP, were observed for the anti-tumor effect of the drugs and were subjected to immunohistochemical study.


RESULTS
1) Tumor reduction was enhanced by the combined use of SPG and CDDP; 2) The survival rate of rats given SPG alone was significantly higher than that of the control rats, and treatment with SPG combined with CDDP tended to improve the survival rate; 3) Immunohistochemically, an infiltrative increase in cytotoxic T-lymphocytes (CTL) was induced, although the development of helper T-cells and macrophages was immunohistochemically weak at the tumor site.


CONCLUSIONS
The administration of SPG enhanced the anti-tumor effect of CDDP.
Sugiyama
T
T
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan.
Nishida
T
T
Kumagai
S
S
Imaishi
K
K
Ushijima
K
K
Kataoka
A
A
Yakushiji
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002273:Carcinogens; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D011916:Rats, Inbred F344; D012566:Sizofiran / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D012566:Sizofiran; D002945:Cisplatin