Identification of non-tissue-specific helix-loop-helix genes in Xenopus laevis.
We have isolated four non-tissue-specific helix-loop-helix (HLH) transcription factors from Xenopus laevis (Xl). While some are clearly orthologous to known mammalian HLH proteins, others have dramatic amino-acid differences in otherwise highly conserved protein domains. We propose that these changes arose following the tetraploidization of Xl approx. 30 Myr ago.
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523, USA.
D H
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Shain
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Zuber
D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D019143:Evolution, Molecular; D018257:Helix-Loop-Helix Motifs / Q000235:genetics*; D008969:Molecular Sequence Data; D011123:Polyploidy; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C489533:TCF12 protein, Xenopus