MitoProt, a Macintosh application for studying mitochondrial proteins.
The paper describes the Macintosh program MitoProt, which is suitable for studying mitochondrion-related proteins. MitoProt supplies a series of parameters that permit theoretical evaluation of mitochondrial targeting sequences, as well as calculation of the most hydrophobic fragment of 17 residues in the sequence, and a new parameter called mesohydrophobicity. The last two calculations are important for predicting the putative importability of a protein into mitochondria. Taken together, targeting sequence and hydrophobicity characteristics enable one to predict whether a given protein could be mitochondrial when no previous information on the nature of the sequence is available.
Ecole Normale Supérieure, Laboratoire de Génétique Moléculaire, CNRS URA 1302, Paris, France.
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Claros
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001665:Binding Sites; D004272:DNA, Mitochondrial / Q000235:genetics; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D008838:Microcomputers; D008928:Mitochondria / Q000737:chemistry*; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D012984:Software
D000596:Amino Acids; D004272:DNA, Mitochondrial; D005656:Fungal Proteins; D011506:Proteins