[The clinical significance of the ratio in FSH/LH of human menopausal gonadotropins in a programmed stimulation regimen for IVF-ET].
Human menopausal Gonadotropin (hMG) has been used in controlled ovarian hyperstimulation (COH) protocol for IVF-ET. We investigated three hMG preparations with different FSH/LH ratios to determine their clinical effectiveness in a programmed stimulation regimen for IVF-ET. Eighty-four IVF-ET candidates at Toho University Hospital received injections of an hMG preparation containing a 3:1 ratio of FSH/LH: Group A, 36 patients received hMG at an FSH/LH 1 : 1 ratio: Group B, and 20 patients receive pure FSH : group C. All received injections of 300IU hMG daily for 7 days according to our COH protocol (=7-day schedule). Analysis determined the serum levels of E2, number of mature follicles, number of retrieved oocytes, fertilization rate, cleavage rate, number of transferred embryos and pregnancy rate. The results were as follows: 1. The serum E2 level was higher in Group A than in Group C with significant differences. 2. The oocyte retrieval rate was significantly higher in Group A. 3. The rate of equally cleaved eggs was significantly higher in Group A. 4. The pregnancy rate was significantly higher in Group A. In conclusion, an hMG preparation containing a 3 : 1 FSH/LH ratio was most suitable in our COH protocol.
Ikenaga
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First Department of Obstetrics and Gynecology, Toho University School of Medicine, Tokyo.
D004334:Drug Administration Schedule; D004339:Drug Compounding; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000737:chemistry; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D007986:Luteinizing Hormone / Q000008:administration & dosage*; D008596:Menotropins / Q000008:administration & dosage* / Q000737:chemistry; D010062:Ovulation Induction; D011247:Pregnancy
D005300:Fertility Agents, Female; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone