Increased concentrations of transferrin in the urine and serum of cattle with cardiomyopathy.
Bovine cardiomyopathy affects adult cattle of the Simmental/red Holstein and Holstein-Friesian breeds and is characterised clinically by signs of congestive heart failure. Animals with cardiomyopathy suffered a marked renal loss of transferrin (Tf). The urinary concentration of Tf discriminated very well between healthy and affected cattle, 93 per cent of the affected and 97 per cent of the healthy cows being identified correctly. In spite of the severe liver congestion and renal loss of Tf, cattle with cardiomyopathy had considerably higher concentrations of serum Tf than healthy cattle. This increase may help to compensate for the low serum concentration of iron in the affected animals. The pronounced changes in the concentrations of iron and transferrin in the serum had little effect on the haemogram of the diseased animals.
Klinik für Nutztiere und Pferde, Universitaet Bern, Switzerland.
H U
HU
Graber
H
H
Pfister
J
J
Martig
D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D009202:Cardiomyopathies / Q000097:blood / Q000652:urine / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D012016:Reference Values; D014168:Transferrin / Q000032:analysis / Q000378:metabolism* / Q000652:urine
D015415:Biomarkers; D006454:Hemoglobins; D014168:Transferrin