Cytotoxic ent-kaurene diterpenoids from Isodon gesneroides.
From Isodon gesneroides, three new cytotoxic diterpenoids, gesneroidins A, B and C, together with one known diterpenoid, dawoensin A, were isolated, and the structure determination and unambiguous assignment of their stereochemistry and NMR spectral data were made by a combination of one-and two-dimensional NMR techniques, computer modelling calculations and X-ray analysis.
Sun
H D
HD
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Yunnan, P.R. China.
Lin
Z W
ZW
Niu
F D
FD
Zhen
Q T
QT
Wu
B
B
Lin
L Z
LZ
Cordell
G A
GA
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D004224:Diterpenes