Endothelial leukocyte adhesion molecule-1-mediated vasoinvasion of human pancreatic adenocarcinoma.
The sialyl Lewis antigens, the ligands of endothelial leukocyte adhesion molecule-1 (ELAM-1), have been used as important tumor markers for the digestive system. The expression of two sialyl Lewis antigens, sialyl Lewis A antigen (SLea) and sialyl Lewis X antigen, was examined in human pancreatic cancer cells. The expression of SLea was dominant, as shown by flow cytometric analysis. Furthermore, suppressive effects of anti-SLea antibody and anti-ELAM-1 antibody on human pancreatic cancer cell vasoinvasion were demonstrated using a new assay system, the vasoinvasion chamber. These results suggest the critical involvement of SLea and ELAM-1 molecules in human pancreatic cancer cell vasoinvasion.
First Department of Surgery, Kobe University School of Medicine, Japan.
M
M
Takada
M
M
Yamamoto
Y
Y
Hasegawa
Y
Y
Saitoh
D000230:Adenocarcinoma / Q000473:pathology*; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D019040:E-Selectin / Q000502:physiology*; D005732:Gangliosides / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness; D009844:Oligosaccharides / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000473:pathology*; D000080506:Sialyl Lewis X Antigen; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D019040:E-Selectin; D005732:Gangliosides; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; C064564:sialyl Le(a) ganglioside