Systemic mycosis caused by a new Cladophialophora species.
A 22-year-old woman suffered from haemoptyses of unknown aetiology. A tumour in the lingula was diagnosed histologically to be a granulomatosis, most likely a sarcoidosis. Two years later, the patient returned with dyspnoea caused by a granulomatous tumour in the trachea, histologically similar to that seen earlier. After bronchoscopic laser resection, cortisone therapy was applied but without success. A fungus was subsequently discovered histologically and was cultivated from biopsy specimens. Retrospective research of primary histological slides led to the conclusion that a mycosis was the initial cause of the tumours. The mycosis was successfully treated with high-dose itraconazole for 1 year, combined with 5-fluorocytosine (5-FC) during the first few months. The causative agent was found to be a new species of Cladophialophora, and is described as C. arxii Tintelnot; its key characteristics are presented.
Tintelnot
K
K
Robert Koch-Institut, Berlin, Germany.
von Hunnius
P
P
de Hoog
G S
GS
Polak-Wyss
A
A
Guého
E
E
Masclaux
F
F
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006099:Granuloma / Q000150:complications / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000302:isolation & purification*
D000935:Antifungal Agents