The Sir David Cuthbertson Medal Lecture. Enteral-feeding-related diarrhoea: proposed causes and possible solutions.
So to summarize the key points: 1. concomitant antibiotic therapy, infected diets and possibly hypoalbuminaemia can lead to enteral-feeding-related diarrhoea; 2. the small intestinal responses to both intragastric and intraduodenal enteral feeding are normal and predictable; 3. there is an ascending colonic secretion during enteral feeding which is more profound during intragastric feeding; 4. the suppression of distal colonic motor activity occurs only during high-load feeding and is probably a secondary phenomenon to the hormonal and secretory responses; 5. peptide YY appears to be intrinsically bound up with the causation of the secretory effect; 6. the secretory effect is abolished by intracaecal SCFA.
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.
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Bowling
D003106:Colon / Q000503:physiopathology; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D004043:Dietary Fiber / Q000008:administration & dosage; D004750:Enteral Nutrition / Q000009:adverse effects*; D005232:Fatty Acids, Volatile / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000503:physiopathology
D004043:Dietary Fiber; D005232:Fatty Acids, Volatile