Diffuse plane xanthomatosis associated with a monoclonal band displaying anti-smooth muscle antibody activity.
We report a patient with diffuse planar xanthomatous lesions associated with a benign monoclonal gammopathy. This patient has a very high titre of anti-smooth muscle antibody (1:10,240), but normal liver function tests and a normal liver biopsy. The paraprotein band displays anti-smooth muscle antibody activity. There is no evidence of any other underlying disease process. The findings are consistent with a diagnosis of diffuse plane xanthomatosis, but the mechanism of xanthoma formation remains unclear.
Department of Clinical Biochemistry, Royal Victoria Hospital, Belfast, U.K.
P C
PC
Sharpe
J F
JF
Dawson
M J
MJ
O'Kane
M Y
MY
Walsh
S A
SA
McMillan
D P
DP
Nicholls
D001323:Autoantibodies / Q000097:blood*; D001365:Axilla; D004586:Electrophoresis; D005145:Face; D005260:Female; D006801:Humans; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology*; D009333:Neck; D012867:Skin / Q000473:pathology; D014973:Xanthomatosis / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies