Immunohistochemical distribution of intestinal 15 kDa protein in human tissues.
The distribution of human intestinal 15 kDa protein (I-15P), a new fatty acid-binding protein (FABP), was observed in normal tissues using immunohistochemical techniques. The antiserum against human I-15P intensely reacted with the villous epithelium of the terminal ileum but not with the enterocytes of the crypts. Although the surface epithelium of the stomach and villous epithelium of the duodenum showed weak reactivities, the epithelial cells of the jejunum, proximal ileum, colon and rectum, and also glandular epithelia with intestinal metaplasia of the stomach were not immunostained. The other human tissues examined were negative for anti-human I-15P antibody. Human I-15P thus represents a distinctive, confined tissue distribution different from the other FABPs and is expected to serve as a useful cellular marker of terminal ileal enterocytes.
Department of Pathology, Fukushima Medical College, Japan.
K
K
Watanabe
N
N
Hoshi
Y
Y
Tsuura
T
T
Kanda
M
M
Fujita
H
H
Fujii
T
T
Ono
T
T
Suzuki
D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology; D018996:Myelin P2 Protein / Q000276:immunology / Q000378:metabolism*; D009363:Neoplasm Proteins; D011994:Recombinant Proteins / Q000276:immunology; D013270:Stomach / Q000166:cytology; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D011994:Recombinant Proteins; D025521:Tumor Suppressor Proteins