Effect of familial hypophosphatemic rickets on dental development: a controlled, longitudinal study.
Familial or X-linked hypophosphatemic rickets (XLHR) is the most common type of rickets in developed countries today. While the dental manifestations of rickets are well reported, there is little information regarding its relationship to dental development and other dental anomalies. This investigation studied the rate of dental development and associated dental anomalies in 19 XLHR subjects compared with 38 race-, age-, and sex-matched control children. The results showed that in both XLHR and control children, no significant differences existed in dental age compared with the respective chronological age, indicating that rickets did not affect the rate of dental development. Longitudinal growth curves of seven XLHR and matched control children substantiated that relationships of dental to chronological ages were comparable in both groups. Male XLHR subjects showed significantly increased tendency for dental taurodontism with mean Crown-Body (CB):Root (R) ratio of 1.1 compared with 1.0 in females and 0.8 in controls (P < 0.02). Male XLHR children also showed significantly increased prevalence (50%) of ectopic permanent canines compared with control children (8%, P < 0.01).
Seow
W K
WK
University of Queensland Dental School, Australia.
Needleman
H L
HL
Holm
I A
IA
D000293:Adolescent; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003481:Cuspid / Q000002:abnormalities; D003786:Dental Pulp Cavity / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D009811:Odontometry; D012744:Sex Ratio; D014070:Tooth / Q000254:growth & development; D014071:Tooth Abnormalities / Q000209:etiology*; D014078:Tooth Eruption; D014079:Tooth Eruption, Ectopic / Q000209:etiology