Novel pyrimidinediones and thiazolidinones as anti depressants.
2-Mercapto-5-[4'-methoxy phenyl thiourea]-1,3,4-thiadiazole (2a-c) prepared by the condensation of 2-amino-5-mercapto-1,3,4-thiadiazole (1) with substituted phenyl isothiocyanates. Further on cyclisation with malonic acid in the presence of acetyl chloride gave the corresponding 2-mercapto-5-[3-(4-methoxy phenyl)-2-thioxo-2-5-dihydro-4, 6-pyrimidionoyl]-1,3,4-thiadiazole (3a-c) [sequence: see text]. This on further reaction with substituted aryl aldehydes in presence of zinc chloride gave 2-mercapto-5-[3-(4'-methoxy phenyl)-2'-thioxo-2',5'-dihydro-4',6' -pyrimidionoyl 5'-phenyl carboxaldehyde]-1,3,4- thiadiazole (4a-g) [sequence: see text]. The compounds were screened for antidepressant activity and compared with antidepressant (imipramine).
Department of Pharmacology & Therapeutics King George's Medical College, Lucknow, India.
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Misra
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Shukla
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Gurtu
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Saxena
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Shanker
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000928:Antidepressive Agents; D011743:Pyrimidines; D013844:Thiazoles