The subcellular localization of 17 beta-hydroxysteroid dehydrogenase type 4 and its interaction with actin.
The porcine 17 beta-hydroxysteroid dehydrogenase type 4 is the key enzyme for the inactivation of estradiol. Its localization in peroxisomes was proven by immunogold electron microscopy. Interactions of the 17 beta-hydroxysteroid dehydrogenase with cytoskeletal proteins might be mandatory for a topical assignment of enzymatic activity to defined subcellular compartments.
Max-Planck-Institut für experimentelle Endokrinologie, Hannover, Germany.
M
M
Markus
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B
Husen
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J
Adamski
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002451:Cell Compartmentation; D004717:Endometrium / Q000201:enzymology* / Q000648:ultrastructure; D004960:Estradiol Dehydrogenases / Q000378:metabolism*; D004971:Estrus; D005260:Female; D007150:Immunohistochemistry; D008830:Microbodies / Q000201:enzymology; D011485:Protein Binding; D013552:Swine
D000199:Actins; D004960:Estradiol Dehydrogenases