Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle.
Transdifferentiation is a relatively rare phenomenon in which cells of one differentiated type and function switch to a second discrete identity. In vertebrate embryos, smooth muscle and skeletal muscle are distinct tissues that arise from separate compartments of the mesoderm. The musculature of the mouse esophagus was found to undergo a conversion from smooth muscle in the fetus to skeletal muscle during early postnatal development. The switch from smooth to skeletal muscle features the transitory appearance of individual cells expressing a mixed phenotype, which suggests that this conversion is a result of programmed transdifferentiation.
Division of Biology, California Institute of Technology, Pasadena 91125, USA.
A
A
Patapoutian
B J
BJ
Wold
R A
RA
Wagner
D000185:Actinin / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D002454:Cell Differentiation / Q000235:genetics*; D005314:Embryonic and Fetal Development; D004947:Esophagus / Q000166:cytology / Q000196:embryology*; D051379:Mice; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D009130:Muscle, Smooth / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D018006:Myogenic Regulatory Factors / Q000378:metabolism; D018995:Myosin Heavy Chains / Q000378:metabolism; D018994:Myosin Light Chains / Q000378:metabolism; D010641:Phenotype
D018006:Myogenic Regulatory Factors; D018994:Myosin Light Chains; D000185:Actinin; D018995:Myosin Heavy Chains