[Leishmania-macrophage interactions: role of cytokines and molecules co-involved in killing].
In this review we have summarized the main data concerning Leishmania-macrophage interactions, with particular emphasis on receptors involved in adhesion, activating or deactivating cytokines and toxic molecules responsible for parasite killing. At present it is also known that a different T helper (Th)1- or Th2-cell response may be critical for the outcome of Leishmania infection in human and in murine models. Therefore, we have mentioned the recent studies on cytokines, such as IL-2, which are able to cause the switch from a Th2, disease-promoting immune response, to a Th1, protective response. In fact, in the light of these findings, these molecules may be used in the future for immunotherapeutical or immunoprophylactic purposes.
Istituto di Malattie Infettive e Parassitarie degli Animali, Università di Bari.
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SM
Faliero
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Marzio
M A
MA
Panaro
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O
Brandonisio
D000818:Animals; D001120:Arginine / Q000502:physiology*; D002448:Cell Adhesion; D016207:Cytokines / Q000502:physiology*; D006790:Host-Parasite Interactions; D006801:Humans; D007891:Leishmania / Q000502:physiology*; D007896:Leishmaniasis / Q000276:immunology / Q000503:physiopathology*; D008264:Macrophages / Q000469:parasitology*; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000502:physiology
D016207:Cytokines; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase
Interazioni Leishmania-macrofago: ruolo delle citochine e delle molecole coinvolte nel killing.