Elevation of serum-soluble E-selectin in atopic dermatitis.
Atopic dermatitis (AD) is characterized by alterations in cellular and humoral immunity. The objective of this study is to determine whether soluble E-selectin (sE-selectin) plays a role in AD. We examined the serum sE-selectin levels in patients with atopic dermatitis (n = 23), patients with urticaria (n = 9), and normal healthy individuals (n = 15). The severity of the disease in the AD patients was graded using an established clinical scoring system. We found that sE-selectin levels were significantly higher in atopic dermatitis than in urticaria (P < 0.001) or normal controls (P < 0.0001). In addition, there was a significant correlation between serum sE-selectin and the clinical score (R = 0.73, P < 0.0001). Clinical improvement was associated with a decrease in both the clinical score (P < 0.01) and serum sE-selectin (P < 0.01). E-selectin was recognized on the vascular endothelial cells of the erythematous lesions of AD patients. These results indicate that sE-selectin may play a role in AD.
Morita
H
H
Department of Dermatology, Hyogo College of Medicine, Japan.
Kitano
Y
Y
Kawasaki
N
N
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D002452:Cell Count; D003876:Dermatitis, Atopic / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D019040:E-Selectin / Q000097:blood* / Q000378:metabolism; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D012016:Reference Values; D012260:Ribonucleases; D012867:Skin / Q000378:metabolism; D012995:Solubility; D014581:Urticaria / Q000097:blood
D001798:Blood Proteins; D019040:E-Selectin; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D007073:Immunoglobulin E; D012260:Ribonucleases