Experimental megaileum.
Typical megaileum occurred in young male Wistar rats three months after ileum myenteric plexus denervation. An average of 58.4% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in an 8 nm ring-shaped histological sectfrom the midportion of the treated segment. A morphometric study showed that the increased thickness of the megaileum wall was due to muscle hypertrophy and mucosal hyperplasia. The potential usefulness of this model of megaileum is emphasized.
Garcia
S B
SB
Department of Morphology, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
Pinto
L Z
LZ
Zucoloto
S
S
Oliveira
J S
JS
D000818:Animals; D001548:Benzalkonium Compounds / Q000633:toxicity; D003714:Denervation / Q000379:methods; D006965:Hyperplasia; D006984:Hypertrophy; D007077:Ileal Diseases / Q000209:etiology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology; D009197:Myenteric Plexus / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D001548:Benzalkonium Compounds