Furazolidone toxicosis in young broiler chicks: morphometric and pathological observations on heart and testes.
Broiler chicks 1 d and 3 w of age were given 0, 400, 800, or 1000 mg furazolidone (Fz)/kg feed for 4 w. Bi-ventricular heart dilatation (as measured by increases in ventricular diameter and thinning of the ventricular walls) was present in 1-d-old chicks fed 800 mg Fz, whereas in 3-w-old groups these changes occurred at 1000 mg Fz. There was no heart hypertrophy. Microscopic changes in the heart were not discernible in and Fz-fed birds. The liver had congestion and cytoplasmic vacuolation of hepatocytes. About 37-50% of the male birds in the different Fz-fed groups had testicular degeneration varying from mild to cystic enlargement. The degenerated testes had dilatation of seminiferous tubules; in cystic testes the seminiferous tubules were extremely dilated and had flattened epithelium. The interstitial tissue between the dilated tubules was compressed and atrophic.
Khan
M Z
MZ
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
Zaman
Q
Q
Islam
N
N
Muhammad
G
G
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity*; D002645:Chickens; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D004108:Dilatation, Pathologic / Q000139:chemically induced / Q000662:veterinary; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005664:Furazolidone / Q000008:administration & dosage / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000473:pathology*; D011201:Poultry Diseases / Q000139:chemically induced; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D000890:Anti-Infective Agents; D005664:Furazolidone