Repair of chronic tympanic membrane perforations with long-term epidermal growth factor.
Chronic tympanic membrane (TM) perforation is a common problem worldwide. Recent reports have shown epidermal growth factor (EGF) to stimulate healing in approximately 80% of chronic TM perforations in chinchillas when applied in three doses over 1 week. The objective of this controlled study is to evaluate the efficacy of long-term EGF in the closure of TM perforations. Chronic chinchilla TM perforations were treated with EGF for up to 6 weeks. One hundred percent (17 of 17) of treatment group perforations completely healed. However, two new findings with this long dosing scheme were reperforation on long-term follow-up and three TMs with cholesteatomas. It is likely that reperforation was due to a progressive thinning seen with prolonged EGF application. Long-term EGF use is not recommended for the treatment of TM perforations because of possible wound healing impairment and possible cholesteatoma induction.
Department of Otolaryngology, Ohio State University, Columbus 43210, USA.
D W
DW
Dvorak
G
G
Abbas
T
T
Ali
S
S
Stevenson
D B
DB
Welling
D000818:Animals; D002682:Chinchilla; D018424:Cholesteatoma, Middle Ear / Q000209:etiology / Q000473:pathology; D002908:Chronic Disease; D004334:Drug Administration Schedule; D004724:Endoscopy; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005781:Gelatin Sponge, Absorbable; D008137:Longitudinal Studies; D010919:Placebos; D012008:Recurrence; D012421:Rupture; D012965:Sodium Chloride; D013997:Time Factors; D014432:Tympanic Membrane / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D014945:Wound Healing
D010919:Placebos; D012965:Sodium Chloride; D004815:Epidermal Growth Factor