[Pruritus--also a challenge in internal medicine].
Generalized or localized itch without primary skin manifestations may be the presenting symptom of serious internal diseases. Five characteristic cases of pruritus are discussed: Hodgkin's disease, primary sclerosing cholangitis, polycythemia vera, iron deficiency (with pica), and uremia. Other important causes must be considered; all forms of cholestasis, including primary biliary cirrhosis, drug-induced, pregnancy-related, and extrahepatic cholestasis; other hematologic and malignant disorders such as non-Hodgkin's lymphoma, leukemia, multiple myeloma, solid tumors, and myelodysplastic syndromes; metabolic and endocrine diseases, most notably diabetes mellitus, hyperthyroidism, hypothyroidism, and carcinoid syndrome; focal neurologic diseases such as brain tumors, cerebral infarctions and multiple sclerosis; adverse drug reactions without rash; infectious diseases, especially parasitic and HIV infections. A diagnostic laboratory screening for pruritus of undetermined origin is suggested.
Brunner
W
W
Medizinische Klinik, Kantonsspital Chur.
D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000150:complications; D015209:Cholangitis, Sclerosing / Q000150:complications; D003937:Diagnosis, Differential; D005260:Female; D006402:Hematologic Diseases / Q000150:complications; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008659:Metabolic Diseases / Q000150:complications; D008875:Middle Aged; D010842:Pica / Q000150:complications; D011087:Polycythemia Vera / Q000150:complications; D011537:Pruritus / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D014511:Uremia / Q000150:complications
Pruritus--auch eine internistische Herausforderung.