Malathion and dichlorvos toxicokinetics after the oral administration of malathion and trichlorfon.
We studied the distribution and persistence of malathion and dichlorvos in the Wistar rat and established their toxicokinetics with the help of the PCNONLIN software program.
Garcia-Repetto
R
R
Instituto Nacional de Toxicologia, Seville, Spain.
Martinez
D
D
Repetto
M
M
D000042:Absorption; D000273:Adipose Tissue / Q000378:metabolism; D000284:Administration, Oral; D000478:Alkylation; D000818:Animals; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D003198:Computer Simulation; D004006:Dichlorvos / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008294:Malathion / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D009132:Muscles / Q000378:metabolism; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D014018:Tissue Distribution; D014236:Trichlorfon / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*
D007306:Insecticides; D000069463:Olive Oil; D010938:Plant Oils; D004006:Dichlorvos; D014236:Trichlorfon; D008294:Malathion