title: CD26 and CD31 surface antigen expression on human colostral T cells.
abstract: The expression levels of CD26 and CD31 surface antigens, two adhesion/activation molecules with helper and suppressor activities, respectively, were found to be significantly higher on human colostral T cells (CD3+) than in autologous peripheral blood samples. These findings provide further phenotypical evidence that immune system T lymphocytes are compartmentalized in the mammary gland late in pregnancy and during lactation. The question of whether these overexpanded T lymphocyte populations in breast milk modulate in situ, either by enhancing or suppressing, the cellular and/or humoral immune response of the suckling infant remains to be answered. Additional studies are, therefore, needed to explore this intriguing field concerning the immunology of the colostrum.
authors.affiliation: Department of Paediatrics, Perugia University School of Medicine, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertotto
authors.forename: F
authors.initials: F
authors.lastname: Spinozzi
authors.forename: R
authors.initials: R
authors.lastname: Gerli
authors.forename: G
authors.initials: G
authors.lastname: Castellucci
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
authors.forename: S
authors.initials: S
authors.lastname: Crupi
authors.forename: G M
authors.initials: GM
authors.lastname: Fabietti
authors.forename: C
authors.initials: C
authors.lastname: Vagliasindi
authors.forename: N
authors.initials: N
authors.lastname: Forenza
authors.forename: P
authors.initials: P
authors.lastname: Pazzelli
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D003126:Colostrum / Q000166:cytology* / Q000276:immunology; D018819:Dipeptidyl Peptidase 4 / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D018819:Dipeptidyl Peptidase 4