title: Composite porosity of expanded polytetrafluoroethylene vascular prosthesis.
abstract: Polytetrafluoroethylene (PTFE) prostheses were modified to produce two types of composite porosity PTFE grafts: type I--inner 60 microns/outer 20 microns and type II--inner 20 microns/outer 60 microns. These composite porosity PTFE designs were investigated for bleed through, graft healing and patency and compared with high porosity PTFE (60 microns) and standard PTFE (20 microns) grafts. The grafts were implanted into the carotid and femoral arteries of dogs and retrieved after 4, 12 and 18 weeks. Both composite porosity grafts showed significantly less bleed through than standard and high porosity grafts after reperfusion. In composite grafts, the 60-microns layer allowed fibrovascular tissue and histiocyte ingrowth from perigraft tissue, but the 20-microns layer did not. Neointima formation occurred earlier and endothelialization was more extensive in high porosity grafts, but seroma formation occurred in 25% of cases. In type I composite porosity grafts, smooth muscle cells of neointima migrated into the pores of the graft, providing a firmly anchored intima. Type II composite porosity grafts allowed better ingrowth of fibrovascular tissue at the outer layer from the perigraft tissue; however, endothelialization was not completed. Composite porosity grafts should be considered for evaluation in specific clinical situations.
authors.affiliation: Department of Surgery, University of California, Irvine Medical Center, Orange, USA.
authors.forename: T
authors.initials: T
authors.lastname: Nagae
authors.forename: H
authors.initials: H
authors.lastname: Tsuchida
authors.forename: S K
authors.initials: SK
authors.lastname: Peng
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: S E
authors.initials: SE
authors.lastname: Wilson
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure; D002455:Cell Division; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure; D006083:Graft Occlusion, Vascular / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D011138:Polytetrafluoroethylene; D016062:Porosity; D017539:Tunica Intima / Q000473:pathology / Q000648:ultrastructure
chemical_list: D011138:Polytetrafluoroethylene