Phenopyrrozin, a new radical scavenger produced by Penicillium sp. FO-2047.
A new radical scavenger, named phenopyrrozin, was isolated from the culture broth of Penicillium sp. FO-2047. Phenopyrrozin was purified from whole broth solvent extraction, silica gel chromatography, and HPLC. The structure of phenopyrrozin was elucidated as 5,6,7,7a-tetrahydro-2-hydroxy-1-phenyl-3H-pyrrolizin-3-one. The IC50 of phenopyrrozin against lipid peroxidation induced by Cr2K2O7 was 73 micrograms/ml. Phenopyrrozin also reduced chromosomal aberrations induced by paraquat.
Shiomi
K
K
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Yang
H
H
Xu
Q
Q
Arai
N
N
Namiki
M
M
Hayashi
M
M
Inokoshi
J
J
Takeshima
H
H
Masuma
R
R
Komiyama
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D016166:Free Radical Scavengers; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D015227:Lipid Peroxidation / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009153:Mutagens / Q000633:toxicity; D010269:Paraquat / Q000633:toxicity; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013057:Spectrum Analysis
D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D009153:Mutagens; D011758:Pyrroles; C097794:phenopyrrozin; D006026:Glycoside Hydrolases; D010269:Paraquat