Recurrent placental site trophoblastic tumor of the uterus: clinical, pathologic, ultrastructural, and DNA fingerprint study.
Placental site trophoblastic tumor is a rare disease. Most benign cases of this disease show a few mitotic figures of the tumor while recurrent cases usually have more than 5 mitoses per 10 high-power fields. The present case was primarily treated by hysterectomy and chemotherapy and had 2 mitoses in 10 high-power fields. After 1 years and 4 months of therapy the patients was diagnosed as ovarian metastasis because of gradually increasing serum beta-human chorionic gonadotropin (hCG) level and abnormally high fluid levels of beta-hCG and human placental lactogen (hPL) punctured from her cystic ovarian tumor. This recurrent case was further treated with another regimen of chemotherapy for 7 courses, and the serum beta-hCG level had decreased at present. This report describes the recurrent case and discusses the histology of a few mitotic figures, electron microscopic findings, and results of the DNA fingerprint analysis of the primary tumor.
Kodama
S
S
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
Kase
H
H
Aoki
Y
Y
Yahata
T
T
Tanaka
K
K
Motoyama
T
T
Dewa
K
K
D000328:Adult; D016172:DNA Fingerprinting; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000235:genetics / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology