Changes of brain anatomy in patients with posttraumatic stress disorder: a pilot magnetic resonance imaging study.
No abnormalities in magnetic resonance images were recorded in patients with posttraumatic stress disorder other than an increased incidence (50%) of a small cleft in the callosal-septal interface, a cavum of the septum pellucidum. A similar grade of cavum was obtained in 14% of normal volunteers matched for age, socioeconomic background, and military experience. The cavum is believed to have antedated the disorder and is conceived to be a neurodevelopmental aberration. The possibility that the cavum is a marker of vulnerability to stress in psychopathology is discussed.
Myslobodsky
M S
MS
Department of Psychology, Tel-Aviv University, Israel.
Glicksohn
J
J
Singer
J
J
Stern
M
M
Bar-Ziv
J
J
Friedland
N
N
Bleich
A
A
D000328:Adult; D001921:Brain / Q000473:pathology*; D003130:Combat Disorders / Q000175:diagnosis* / Q000523:psychology; D003337:Corpus Callosum / Q000473:pathology; D005260:Female; D006801:Humans; D007861:Lebanon; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D012016:Reference Values; D012688:Septum Pellucidum / Q000473:pathology