title: Double renal transplant from infant donors. A good alternative for adult recipients.
abstract: Several groups have reported technical complications and poor graft survival rates in kidney transplants from pediatric donors to adult recipients. Increased incidences of acute rejections, vascular thrombosis, and early glomerulosclerotic lesions have led many groups to abandon this graft combination. Over the last 4 years, we have set up a program of two-kidney transplantation from cadaveric infant donors under age 3 years, which to date includes 15 adult recipients. Thirteen of these grafts are currently functioning at least as well as those from adult donors, after a mean follow-up of 1.5 years. Our surgical and therapeutic procedures have led to a minimization of the early complications reported by other groups. With this transplantation procedure, the patients receive double the number of nephrons, which will probably give them better long-term function. The encouraging results achieved by our group may help change the current consideration of pediatric donors as "suboptimal" ones.
authors.affiliation: Departamentos de Nefrología y Cirugía, Hospital Universitario S. Carlos, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Portolés
authors.forename: A
authors.initials: A
authors.lastname: Marañes
authors.forename: D
authors.initials: D
authors.lastname: Prats
authors.forename: J
authors.initials: J
authors.lastname: Torrente
authors.forename: B
authors.initials: B
authors.lastname: Marrón
authors.forename: M J
authors.initials: MJ
authors.lastname: Perez-Contín
authors.forename: J A
authors.initials: JA
authors.lastname: Herrero
authors.forename: F
authors.initials: F
authors.lastname: Coronel
authors.forename: J
authors.initials: J
authors.lastname: Grimalt
authors.forename: A
authors.initials: A
authors.lastname: Barrientos
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D014019:Tissue Donors