The structural basis of nuclear function.
Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.
Jackson
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CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
Cook
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D000818:Animals; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry; D006801:Humans; D015530:Nuclear Matrix / Q000648:ultrastructure; D011487:Protein Conformation
D002843:Chromatin; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase