[Neuromodulation of synaptic transmission with thymopentin].
The effect of thymopentin (TP-5; 1 x 10(-5) and 1 x 10(-4) M), the active center of the thymic hormone thymopoietin was examined upon spontaneous and induced neuromuscular synaptic activity (N-MS) in the isolated diaphragm of Wistar-strain rat. Standard electrophysiological method of intracellular registration was used. Analysis of original experimental microphysiologic results revealed clear depressant neuromodulative effect of TP-5 upon skeletal N-MS in vitro. Effect of TP-5 is expressed in decreased amount of the released median quantal value of neurotransmitter acetylcholine at orthodromic stimulation of the alpha-motor nerve. TP-5 also reduces chemiosensitivity of postsynaptic nicotinic acetylcholine receptors.
Malicević
Z
Z
Vojnomedicinska akademija, Institut za medicinska istrazivanja, Beograd.
Kojić
L Z
LZ
Stamenović
B A
BA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003964:Diaphragm / Q000294:innervation; D066298:In Vitro Techniques; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects*; D016305:Thymopentin / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D016305:Thymopentin
Neuromodulacija sinapticke transmisije timopentinom.