title: Acute occlusive ischemia of the rat intestine: early detection by MR imaging with polylysine-Gd-DTPA enhancement.
abstract: The purpose of this study was to assess the potential role of MR imaging with polylysine-Gd-DTPA enhancement in the early detection of acute occlusive intestinal ischemia in a rat model. After devascularization of the distal ileum in 12 rats, T2-weighted fast spin-echo MR images were acquired, followed by T1-weighted images before and after IV administration of 0.1 mmol/kg polylysine-Gd-DTPA. The signal intensity of the ischemic intestine did not differ significantly from that of the normal intestine before the administration of the contrast material. No mucosal or submucosal edema or hemorrhage was found in the ischemic intestine at histologic examination. After the administration of polylysine-Gd-DTPA, the ischemic intestine lacked enhancement and its signal intensity was significantly lower than that of the normal intestine. MR imaging with polylysine-Gd-DTPA enhancement can detect acute occlusive ischemia of the rat intestine at an early stage.
authors.affiliation: Department of Radiology, University of Louvain, St-Luc University Hospital, Brussels, Belgium.
authors.forename: B E
authors.initials: BE
authors.lastname: Van Beers
authors.forename: I
authors.initials: I
authors.lastname: Mottet
authors.forename: M
authors.initials: M
authors.lastname: Delos
authors.forename: J F
authors.initials: JF
authors.lastname: Goudemant
authors.forename: R
authors.initials: R
authors.lastname: Demeure
authors.forename: J
authors.initials: J
authors.lastname: Pringot
mesh_terms: D000208:Acute Disease; D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D019786:Gadolinium DTPA; D007089:Image Enhancement; D007275:Injections, Intravenous; D007422:Intestines / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011107:Polylysine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D004369:Pentetic Acid; D019786:Gadolinium DTPA