Systemic lupus erythematosus relapse with lupus cystitis.
A 45-year-old woman who had been diagnosed as having systemic lupus erythematosus (SLE) at the age of 28 years and who had been in remission developed severe urinary frequency, watery diarrhea, vomiting and weight loss. She also developed acute renal failure and her serological examination was consistent with active SLE. She had a markedly decreased urinary bladder capacity of 20 ml with hydroureteronephrosis. Histopathological study of her urinary bladder biopsy specimen showed mucosal edema, infiltration by lymphocytes and granulocytes, and deposition of IgA in the epithelium and submucosal region. We diagnosed this as a case of lupus cystitis. The patient's symptoms were alleviated by bilateral nephrostomy and corticosteroid therapy. In the present episode the patient showed none of the usual symptoms of SLE. This case and others reported in the literature show that lupus cystitis presents with specific signs and symptoms and therefore, this syndrome may represent a specific clinical manifestation of SLE.
Nakauchi
Y
Y
Second Department of Internal Medicine, Kochi Medical School, Japan.
Suehiro
T
T
Tahara
K
K
Kumon
Y
Y
Yasuoka
N
N
Ohashi
Y
Y
Kawada
M
M
Hashimoto
K
K
D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D018856:Cystitis, Interstitial / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D012008:Recurrence