Prevalence of latex-specific IgE antibodies in hospital personnel.
BACKGROUND
Rubber latex hypersensitivity is an important concern for health care workers.


OBJECTIVE
The Center for Devices and Radiological Health, in collaboration with the Consumer Product Safety Commission, conducted a multicenter study of the prevalence of latex-specific IgE antibodies among United States hospital personnel.


METHODS
Nine hospitals participated in the cross-sectional study. A total of 504 hospital personnel completed questionnaires that provided an array of demographic, occupational, and clinical information, including a history, if any, of allergies and the use of latex and nonlatex gloves. More than three-quarters (76.5%) of the participants were tested for total IgE and latex specific IgE.


RESULTS
A total of 21 (5.5%, 95% CI = 3%-7%) of the tested participants were positive for the presence of latex specific IgE antibodies, defined as a latex IgE level of > or = 0.6 ng/mL. Latex specific IgE antibodies were more prevalent in participants who reported tachycardia, palpitations, flushing, or wheezing associated with latex gloves (Odds Ratio = 10.2, 95% CI = 3.7-28.6).


CONCLUSIONS
The study's results suggest that the prevalence of latex-specific IgE antibodies among hospital personnel is appreciable and these personnel and their health care providers should be aware of this entity.
Kaczmarek
R G
RG
Center for Devices and Radiological Health, Rockville, Maryland, USA.
Silverman
B G
BG
Gross
T P
TP
Hamilton
R G
RG
Kessler
E
E
Arrowsmith-Lowe
J T
JT
Moore
R M
RM
D000328:Adult; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D009783:Dermatitis, Occupational / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D005260:Female; D005932:Gloves, Surgical; D006229:Hand Dermatoses / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007840:Latex / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D010564:Personnel, Hospital; D015995:Prevalence; D012408:Rubber / Q000009:adverse effects; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
D007840:Latex; D007073:Immunoglobulin E; D012408:Rubber