title: [Neurobrucellosis. A report of 13 cases].
abstract: Thirteen patients with nervous system brucellosis are described. The clinical signs were heterogeneous: meningoencephalitis in 5 cases, meningoradiculitis in another 5, meningomyelitis with cranial neuropathy in 1 and of a vascular nature in 2 others. Neurologic signs appeared during the active phase in 5 patients and later in 8. Diagnosis was based on clinical manifestations, serum and cerebrospinal fluid (CSF) serology, quantitative changes in CSF and favorable response to treatment. Therapy consisted of a combination of 2 or 3 of the following drugs: rifampin, doxycycline, streptomycin and trimethoprim sulfamethoxazole. In spite of favorable evolution, 5 patients suffered sequelae. We suggest that brucellosis be investigated when neurologic deficit ensues with no known etiology, especially in endemic countries.
authors.affiliation: Servicio de Neurología, Hospital Miguel Servet, Zaragoza.
authors.forename: M E
authors.initials: ME
authors.lastname: Marzo Sola
authors.forename: C
authors.initials: C
authors.lastname: Calderón Girón
authors.forename: T
authors.initials: T
authors.lastname: Ayuso Blanco
authors.forename: M
authors.initials: M
authors.lastname: Usón Martín
authors.forename: M E
authors.initials: ME
authors.lastname: Marta Moreno
authors.forename: M
authors.initials: M
authors.lastname: Bestué Cardiel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D001921:Brain / Q000382:microbiology* / Q000503:physiopathology; D002002:Brucella / Q000302:isolation & purification; D002006:Brucellosis / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular
vernacular_title: Neurobrucelosis. Aportación de 13 casos.