title: Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis.
abstract: The effects of oxytocin on the percentage of technetium 99m albumin colloid (99mTc-microAA), cleared from the uterine lumen was measured in 13 mares. Scintigraphy was performed during 4 consecutive oestrous cycles, on Day 3 of oestrus during Cycles one and 3 and 48 h after ovulation during Cycles 2 and 4. Oxytocin (20 iu) was given i.v. after the initial scintigraphy image during Cycles 3 and 4. Seven multiparous mares (Group 1) were classified as 'susceptible' and 6 mares (2 nulliparous and 4 multiparous; Group 2) were classified as 'resistant' to endometritis. All mares cleared > 90% of 99mTc-microAA within 30 min of oxytocin injection. When no drug was given, Group 1 mares cleared negligible amounts of radiocolloid (< 5%) and Group 2 mares cleared 50-80%. No mares showed signs of colic after oxytocin administration. It is concluded that oxytocin enhances uterine clearance of radiocolloid and may be useful for treating mares exhibiting impaired uterine clearance.
authors.affiliation: Department of Large Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville 32610, USA.
authors.forename: M
authors.initials: M
authors.lastname: LeBlanc
authors.forename: L
authors.initials: L
authors.lastname: Neuwirth
authors.forename: D
authors.initials: D
authors.lastname: Mauragis
authors.forename: E
authors.initials: E
authors.lastname: Klapstein
authors.forename: T
authors.initials: T
authors.lastname: Tran
mesh_terms: D000818:Animals; D003102:Colloids; D004198:Disease Susceptibility; D004716:Endometritis / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000378:metabolism / Q000503:physiopathology*; D006736:Horses; D010060:Ovulation / Q000502:physiology; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D011877:Radionuclide Imaging; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D013668:Technetium Tc 99m Aggregated Albumin / Q000493:pharmacokinetics; D014599:Uterus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology
chemical_list: D003102:Colloids; D010120:Oxytocics; D013668:Technetium Tc 99m Aggregated Albumin; D010121:Oxytocin