Providing distinct vergence and version dynamics in a bilateral oculomotor network.
Given reported interactions between vergence and version dynamics, ocular reflexes cannot be properly modelled as separate independent subsystems. Using a model structure compatible with known anatomy, we show that a single bilateral system can produce results consistent with observed data both at the central and ocular levels. This model provides for both vergence and conjugate integrators in a single controller, and explains the observed modulation on abducens interneurons and mesencephalic vergence cells during vergence responses. Reported interactions between version and vergence would then be a natural consequence of a shared premotor network. Major implications include: the need to record both eyes in a protocol, since cross-talk is always possible; and adaptation to monocular changes could be distributed in all motor projections to both eyes.
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Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
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D000010:Abducens Nerve / Q000502:physiology; D000465:Algorithms; D003290:Convergence, Ocular / Q000502:physiology; D003624:Darkness; D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular; D006801:Humans; D008027:Light; D008636:Mesencephalon / Q000502:physiology; D008954:Models, Biological; D009415:Nerve Net / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D014726:Vestibular Nuclei / Q000502:physiology; D015348:Vision, Binocular / Q000502:physiology*; D015349:Vision, Monocular / Q000502:physiology