[Evolutionary programming for finding "structure-activity" relationships in a series of 3-phenoxychromone and 3-phenoxy-4-hydroxycoumarin derivatives].
Based on a set of compounds possessing hypolipidemic activity, it was demonstrated that evolutionary algorithms can be successfully used to compile an informative set of molecular parameters. The parameter sets selected using the method of potential functions allowed correct prediction of the activity of test molecules.
Tetko
I V
IV
Tanchuk
V Iu
VIu
Vasil'ev
S A
SA
Khilia
V P
VP
Poda
G I
GI
Luĭk
A I
AI
D015110:4-Hydroxycoumarins / Q000737:chemistry* / Q000494:pharmacology; D000465:Algorithms; D002867:Chromones / Q000737:chemistry* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
C097882:3-phenoxychromone; D015110:4-Hydroxycoumarins; D002867:Chromones; D000960:Hypolipidemic Agents; C097883:3-phenoxy-4-hydroxycoumarin
Evoliutsionnoe programmirovanie dlia vyiavleniia zakonomernosteĭ "struktura-aktivnost" v riadu proizvodnykh 3-fenoksikhromona i 3-fenoksi-4-gidroksikumarina.