Ethanol decreases basal cytosolic-free calcium concentration in cultured skeletal muscle cells.
We analysed the effect of ethanol on basal cytosolic-free calcium concentration ([Ca2+]i) in cultured rat myocytes. Ethanol caused a dose-dependent decrease of the resting [Ca2+]i. Removal of ethanol was followed by a transitory increase of [Ca2+]i above the basal level. In cells chronically exposed to ethanol, [Ca2+]i normalized to the previous level.
Cofán
M
M
Department of Internal Medicine, Hospital Clínic, University of Barcelona, Spain.
Fernandez-Solà
J
J
Nicolás
J M
JM
Poch
E
E
Urbano-Márquez
A
A
D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D046508:Culture Techniques; D003600:Cytosol / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
D000431:Ethanol; D002118:Calcium