Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7.
The chromosomal localizations of Scnn1b and Scnn1g, genes corresponding to the beta- and gamma-subunits, respectively, of an epithelial non-voltage-gated amiloride-sensitive sodium channel, were determined by analyses of two sets of multilocus crosses using probes generated by polymerase chain reaction and a mouse kidney cortical collecting tubule cell line (M1). Scnn1b and Scnn1g were determined to be closely linked on distal mouse chromosome 7, showing no recombination with Zp2, whereas the gene for the alpha-subunit, Scnn1a, was confirmed to map to distal mouse chromosome 6.
Brooker
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DR
Department of Medicine, University of Pennsylvania, Philadelphia 19104-6144, USA.
Kozak
C A
CA
Kleyman
T R
TR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D017931:DNA Primers; D053503:Epithelial Sodium Channels; D004848:Epithelium / Q000378:metabolism; D008040:Genetic Linkage; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D017386:Sequence Homology, Amino Acid; D015222:Sodium Channels / Q000235:genetics*
D017931:DNA Primers; D053503:Epithelial Sodium Channels; C507047:Scnn1a protein, mouse; C507049:Scnn1b protein, mouse; C507050:Scnn1b protein, rat; C507053:Scnn1g protein, mouse; C507054:Scnn1g protein, rat; D015222:Sodium Channels