The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.
Gabapentin has come into clinical use as adjunctive therapy in the treatment of epilepsy. Designed to mimic gamma-aminobutyric acid (GABA), its mechanism of action remains elusive. In vivo measurements of GABA in human brain were made using 1H magnetic resonance spectroscopy. We used a 2.1-T magnetic resonance imager-spectrometer and an 8-cm surface coil to measure a 13.5-cm3 volume in the occipital cortex. GABA levels were measured in 14 patients enrolled in an open-lbel trial of gabapentin. GABA was elevated in patients taking gabapentin compared with 14 complex partial epilepsy patients, matched for antiepileptic drug treatment. Brain GABA levels appeared to be higher in patients taking high-dose gabapentin (3,300-3,600 mg/day) than in those taking standard doses (1,200-2,400 mg/day). Gabapentin appears to increase human brain GABA levels.
Petroff
O A
OA
Department of Neurology, Yale University, New Haven, CT 06510, USA.
Rothman
D L
DL
Behar
K L
KL
Lamoureux
D
D
Mattson
R H
RH
D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology; D003509:Cyclohexanecarboxylic Acids; D004305:Dose-Response Relationship, Drug; D017029:Epilepsy, Complex Partial / Q000378:metabolism*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000187:drug effects* / Q000378:metabolism; D011522:Protons; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D011522:Protons; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin