title: [Immunology of tuberculosis].
abstract: Protective immunity against Mycobacterium tuberculosis is mediated by specific T lymphocytes and executed by mononuclear phagocytes. The crosstalk between distinct T cell subsets and macrophages involves various cytokines. Attraction of blood monocytes to the site of mycobacterial replication and local macrophage activation result in granuloma formation. Interactions between T cell subsets and macrophages within granulomas enable the host to restrict mycobacterial growth, but only rarely cause sterile eradication. Therefore, at later time points, active tuberculosis may develop as a consequence of weakened immunity.
authors.affiliation: Abteilung für Immunologie, Universität Ulm und Max-Planck-Institut für Infektionsbiologie, Berlin.
authors.forename: S H
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008211:Lymphocyte Cooperation / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D010587:Phagocytosis; D013601:T-Lymphocytes / Q000276:immunology; D014375:Tuberculoma / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
vernacular_title: Immunologie der Tuberkulose.