title: Dishevelled is a component of the frizzled signaling pathway in Drosophila.
abstract: The tissue polarity genes in Drosophila are required to coordinate cell polarity within the plane of the epidermis. Evidence to date suggests that these genes may encode components of a novel signal transduction pathway. Three of the genes, frizzled (fz), dishevelled (dsh), and prickle (pk) share a similar tissue polarity phenotype, suggesting that they function together in a single process. dsh is also known to function as a mediator of wingless (wg) signaling in a variety of developmental patterning processes in the fly. In this study, we make use of a fz transgene and a hypomorphic fz allele as genetic tools in an attempt to order these genes in a genetic hierarchy. Our results argue that dsh encodes a dosage sensitive component required for fz function and that it likely acts downstream of fz in the generation of tissue polarity. Our findings suggest that dsh may have a general role in signal transduction, perhaps as a component of a receptor complex.
authors.affiliation: Biology Department, University of Virginia, Charlottesville 22903, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Krasnow
authors.forename: L L
authors.initials: LL
authors.lastname: Wong
authors.forename: P N
authors.initials: PN
authors.lastname: Adler
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D016764:Cell Polarity / Q000235:genetics; D000072261:Dishevelled Proteins; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins; D004817:Epidermis / Q000196:embryology*; D051157:Frizzled Receptors; D017344:Genes, Insect; D008565:Membrane Proteins / Q000235:genetics*; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation; D010641:Phenotype; D010750:Phosphoproteins; D011506:Proteins / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction / Q000235:genetics*; D014921:Wings, Animal / Q000033:anatomy & histology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008565:Membrane Proteins; D010750:Phosphoproteins; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; C000606588:dsh protein, Drosophila; C058784:fz protein, Drosophila