Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract.
Studies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. In the vitamin E sufficient group a significantly lower IL-6 concentration than in vitamin E deficient animals was observed. Addition of tea extract to the diet produced a similar reduction in IL-6, but no synergism occurred in the presence of both vitamin E and tea extract. However, a significantly lower caeruloplasmin and a significantly higher liver glutathione concentration was observed in rats fed both substances. It is suggested that consideration of dietary components which alter antioxidant/oxidant status may contribute towards treatment of inflammatory/autoimmune diseases.
Amarakoon
A M
AM
Department of Human Nutrition, University of Southampton, UK.
Tappia
P S
PS
Grimble
R F
RF
D000704:Analysis of Variance; D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005419:Flavonoids; D005978:Glutathione / Q000378:metabolism; D015850:Interleukin-6 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010636:Phenols / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology; D059808:Polyphenols; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet; D013662:Tea / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects
D005419:Flavonoids; D015850:Interleukin-6; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D014810:Vitamin E; D002570:Ceruloplasmin; D005978:Glutathione