Hypothesis on cellular ATP depletion and adenosine release as causes of heart failure and vasodilatation in cardiovascular beriberi.
Cardiovascular beriberi is a syndrome caused by thiamine deficiency and characterized by systemic vasodilatation, heart failure and lactic acidosis. The occurrence of heart failure and vasodilatation is yet unexplained: neither theoretical nor experimental data are known. In this article, it is suggested that a fall of cellular ATP levels causes heart failure and that the release of adenosine is the cause of vasodilatation.
Bakker
S J
SJ
Department of Nephrology, University Hospital Maastricht, The Netherlands.
Leunissen
K M
KM
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000140:Acidosis, Lactic / Q000209:etiology / Q000378:metabolism; D000241:Adenosine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D001602:Beriberi / Q000150:complications* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D006333:Heart Failure / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007655:Ketoglutarate Dehydrogenase Complex / Q000172:deficiency / Q000502:physiology*; D008954:Models, Biological; D015325:Pyruvate Dehydrogenase Complex Deficiency Disease / Q000209:etiology* / Q000378:metabolism; D013831:Thiamine / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
D000431:Ethanol; D000105:Acetyl Coenzyme A; D000255:Adenosine Triphosphate; D007655:Ketoglutarate Dehydrogenase Complex; D000241:Adenosine; D013831:Thiamine