title: Epidemiology and outcome of cervical dystonia (spasmodic torticollis) in Rochester, Minnesota.
abstract: The natural history of cervical dystonia (spasmodic torticollis) was investigated in a population-based study in Rochester, Minnesota. Eleven new cases were identified with onset during the 20-year period 1960-1979. The overall incidence rate was 1.2 per 100,000 person-years (95% confidence interval 0.5-1.9) with a female:male ratio of age-adjusted incidence rates of 3.6:1. A unitary etiology was not apparent: injury antedated onset in four of the 11 patients, whereas six had documented thyroid disease and four had diabetes. A family history of movement disorder was recorded for only one subject. Only one of the cases would have been classified as moderate in severity; the others were mild. In follow-up through 1993, progressive disability was noted in only two patients, and two others went into remission. Three cases of intracranial aneurysm were confirmed, two of which produced fatal subarachnoid hemorrahage. A third death was due to amyotrophic lateral sclerosis.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Claypool
authors.forename: D D
authors.initials: DD
authors.lastname: Duane
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
authors.forename: L J
authors.initials: LJ
authors.lastname: Melton
mesh_terms: D017668:Age of Onset; D002574:Cervical Vertebrae / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D009333:Neck / Q000503:physiopathology; D013035:Spasm / Q000150:complications* / Q000503:physiopathology; D014103:Torticollis / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D014481:United States / Q000453:epidemiology