title: Ontogeny of two different benzodiazepine binding sites in the chick optic lobe.
abstract: The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development.
authors.affiliation: Instituto de Biología Celular, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Gravielle
authors.forename: S F
authors.initials: SF
authors.lastname: de Plazas
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001665:Binding Sites; D002645:Chickens; D005445:Flunitrazepam / Q000378:metabolism; D007700:Kinetics; D011724:Pyridazines / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D003336:Tectum Mesencephali / Q000254:growth & development / Q000378:metabolism*
chemical_list: D014151:Anti-Anxiety Agents; D011724:Pyridazines; D011963:Receptors, GABA-A; D005445:Flunitrazepam; C021604:CL 218872