[Proton-magnetic resonance spectroscopy (1H-MRS) of human plasma obtained from patients with various cancer--new detection method for common cancer].
1H-Magnetic Resonance (MR) Spectra of plasma obtained from patients with various cancer were measured. Clinical usefulness of 1H-MRS assay for detection of common cancer was examined. The following results were obtained. 1. High lactate peak was detected significantly with 1H-MR Spectra of plasma in every cancer patients. The patterns of 1H-MR spectra were very similar in each case, except for the lactate peak. 2. Lactate values (area ratio of lactate peak to TSP) of cancer patients showed high correlation with tumor marker of AFP, but not significant with CEA and CA19-9. 3. 1H-MRS assay has many advantages in the clinical examination. From these results, it was concluded that lactate peak in 1H-MRS might be useful to detect common cancer as a new tumor marker and 1H-MRS assay was equipped with enough characters as a new clinical laboratory assay for detection of specific metabolic deficiency.
Itoh
Y H
YH
Department of Radiology, Aichi Medical University.
Kikuchi
A
A
Kobayashi
M
M
Oguri
T
T
D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D007773:Lactates / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000175:diagnosis*; D011522:Protons; D000509:alpha-Fetoproteins / Q000032:analysis
D014408:Biomarkers, Tumor; D007773:Lactates; D011522:Protons; D000509:alpha-Fetoproteins