The effect of unkei-to on pituitary gonadotropin secretion and ovulation in anovulatory cycles of young women.
Unkei-to (TJ-106) induced significant increases of plasma follicle stimulating hormone level in the first grade (P < 0.05), second grade amenorrhea without weight loss (P < 0.05), and weight loss related to second grade amenorrhea (P < 0.01) in eight weeks of treatment, respectively. Plasma estradiol level significantly increased 1.8 times in 4 week treatment with Unkei-to in first grade amenorrhea (P < 0.01). In second grade amenorrhea without weight loss and weight loss related second grade amenorrhea, plasma estradiol level significantly increased 2.9 times (P < 0.01) and 1.7 times (P < 0.05) in 8 weeks treatment, respectively. On the other hand, the patterns of pulsatile secretion of follicle stimulating hormone and luteinizing hormone remarkably improved by the treatment with Unkei-to. In the patients with second grade amenorrhea, follicles stimulating hormone and luteinizing hormone pulses appeared in 3 out of 13 (23.1%) and 6 out of 13 (46.2%) with the treatment of Unkei-to, respectively in 85% of whom no pulses has been observed before the treatment. Ovulation occurred in 62.2% (23/37), 26.6% (4/15), and 21.7% (5/23) of the patients with first grade, second grade amenorrhea without weight loss, and weight loss related second grade amenorrhea by the treatment with Unkei-to, respectively. These results indicate that Unkei-to is effective on improvement of gonadotropin pulsatile secretion in the treatment of anovulatory women. This suggests that Unkei-to may enhance the pituitary response to Gn-RH or improvement of the pulsatile secretion of Gn-RH, inducing normalization of diencephalon-pituitary-ovarian endocrine system in the anovulatory patients.
Ushiroyama
T
T
Department of Obstetrics and Gynecology, Osaka Medical College, Japan.
Tsubokura
S
S
Ikeda
A
A
Ueki
M
M
D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D010060:Ovulation / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects*; D013997:Time Factors
D006062:Gonadotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone