[Activity of blood antioxidant enzymes in chronic liver damage].
Patients with chronic hepatic disease have higher superoxide dismutase (SOD) activity and lower erythrocytic glutathione levels. There was a decrease in plasma SOD activity in cirrhosis, a feedback between the dismutase and oxidase activities of ceruloplasmin in cholestatic damages to the liver. Drug therapy resulted in positive dynamics in the levels of SOD, glutathione peroxidase, glutathione, ceruloplasmin, which is likely to be associated with the control of the enzymatic mechanisms of antioxidative protection. It is suggested that the enhanced erythrocytic SOD activity in hepatic diseases might trigger free radical oxidation.
Matiushin
B N
BN
Loginov
A S
AS
Iakimchuk
G N
GN
Tkachev
V D
VD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002908:Chronic Disease; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000201:enzymology*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione
Aktivnost' antioksidantnykh fermentov krovi pri khronicheskikh porazheniiakh pecheni.