title: Tetracyclines and calcified tissues.
abstract: Tetracyclines are widely used in medical and dental practice. Since these drugs chelate calcium salts they are incorporated into bones and teeth during calcification. A review of the literature on the pharmacology of these drugs, their incorporation into calcified tissues and the management of tetracycline-stained teeth is given.
authors.affiliation: Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: van der Bijl
authors.forename: G
authors.initials: G
authors.lastname: Pitigoi-Aron
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002113:Calcification, Physiologic / Q000187:drug effects; D002118:Calcium / Q000493:pharmacokinetics; D002614:Chelating Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D013754:Tetracyclines; D014070:Tooth / Q000187:drug effects* / Q000378:metabolism; D014075:Tooth Discoloration / Q000139:chemically induced / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D013754:Tetracyclines; D002118:Calcium