[Damage to the catecholaminergic system causes a slowing in the formation of early behavioral reactions in rats].
Influence of 6-hydroxydopamine (6-OHDA) on catecholaminergic brain system and development of early behavioural patterns was studied in 1-20-days-old Wistar rats. After 6-OHDA neonatal injection the number on catecholaminergic terminals in deep layers of pons-medulla was considerably reduced while the number of catecholaminergic neurons was 2-3 times increased. Damage of catecholaminergic innervation of the forebrain of rats was shown to cause a delay in development of washing behaviour, searching activity and disturbance of orientation in new environment.
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D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D009498:Neurotoxins / Q000494:pharmacology; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D017983:Receptors, Catecholamine / Q000187:drug effects / Q000502:physiology*; D018709:Statistics, Nonparametric; D013997:Time Factors
D009498:Neurotoxins; D017983:Receptors, Catecholamine; D016627:Oxidopamine
Povrezhdenie katekholaminergicheskoĭ sistemy obuslovlivaet zamedlenie fomirovaniia rannikh povedencheskikh reaktsiĭ u krys.