title: Hantavirus pulmonary syndrome in Florida: association with the newly identified Black Creek Canal virus.
abstract: Hantavirus pulmonary syndrome (HPS) is a recently recognized viral zoonosis. The first recognized cases were caused by a newly described hantavirus. Sin Nombre virus (previously known as Muerto Canyon virus), isolated from Peromyscus maniculatus (deer mouse). We describe a 33-year-old Floridian man who resided outside the ecologic range of P maniculatus but was found to have serologic evidence of a hantavirus infection during evaluation of azotemia associated with adult respiratory distress syndrome. Small mammal trapping conducted around this patient's residence demonstrated the presence of antihantaviral antibodies in 13% of Sigmodon hispidus [cotton rat). Serologic testing using antigen derived from the Black Creek Canal hantavirus subsequently isolated from this rodent established that this patient was acutely infected with this new pathogenic American hantavirus. HPS is not confined to the geographical distribution of P maniculatus and should be suspected in individuals with febrile respiratory syndromes, perhaps associated with azotemia, throughout the continental United States.
authors.affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Gaviria
authors.forename: P E
authors.initials: PE
authors.lastname: Rollin
authors.forename: W G
authors.initials: WG
authors.lastname: Hlady
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: L R
authors.initials: LR
authors.lastname: Armstrong
authors.forename: R
authors.initials: R
authors.lastname: Greenman
authors.forename: E
authors.initials: E
authors.lastname: Ravkov
authors.forename: M
authors.initials: M
authors.lastname: Kolber
authors.forename: H
authors.initials: H
authors.lastname: Anapol
authors.forename: E D
authors.initials: ED
authors.lastname: Sfakianaki
authors.forename: S T
authors.initials: ST
authors.lastname: Nichol
authors.forename: C J
authors.initials: CJ
authors.lastname: Peters
authors.forename: R F
authors.initials: RF
authors.lastname: Khabbaz
mesh_terms: D058186:Acute Kidney Injury / Q000821:virology; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005431:Florida; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000276:immunology; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D008297:Male; D051379:Mice; D011654:Pulmonary Edema / Q000821:virology; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000821:virology; D016205:Sigmodontinae / Q000821:virology; D014511:Uremia / Q000821:virology; D015047:Zoonoses
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral