Unifying concept of pharmacokinetics derived from drug distribution and elimination in renal failure.
We are in the process of establishing a pharmacokinetic database for drug dosage adjustment to impaired renal function. To meet these demands, the system needs a unifying pharmacokinetic concept. Drug clearance is the common parameter that allows for intersecting the different pharmacokinetic approaches. In addition, two parameters are essentially needed for the concept, either the area-derived volume and the dominant elimination half-life or the moment-derived volume and the mean residence time. For drugs where the area-derived volume decreases with renal impairment, it can be shown that compartment-derived parameters are explicitly convertible into moment-derived parameters and vice versa.
Keller
F
F
University Hospital, Medical Department, Ulm.
Frankewitsch
T
T
Zellner
D
D
Simon
S
S
D004304:Dosage Forms / Q000592:standards*; D006207:Half-Life; D007256:Information Systems; D015233:Models, Statistical; D010599:Pharmacokinetics; D012015:Reference Standards; D051437:Renal Insufficiency / Q000378:metabolism*; D014018:Tissue Distribution
D004304:Dosage Forms