[A relationship between the breakpoint of the bcr gene and some hematologic parameters in patients with chronic myelogenous leukemia].
We examined the hybrid bcr/abl mRNA present in 59 patients with chronic myeloid leukemia, using the reverse transcription method and polymerase chain reaction. Bcr/abl gene was found in 98% of patients. 60% of patients had b3a2 type of translocation, 40% type b2a2. Patients with b3a2 type had higher platelet count at diagnosis presentation than patients with b2a2. Other hematological data were similar in both groups.
Seferyńska
I
I
Pracowni Biologii Molekularnej Zakładu Serologii Instytutu Hematologii i Transfuzjologii w Warszawie.
Brojer
E
E
Sankowska
M
M
Majewski
M
M
Maj
S
S
D002873:Chromosome Fragility; D017931:DNA Primers; D005260:Female; D016313:Genes, abl; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012333:RNA, Messenger / Q000032:analysis*; D014178:Translocation, Genetic / Q000235:genetics
D017931:DNA Primers; D012333:RNA, Messenger
Zalezność miedzy miejscem złamania genu bcr a niektórymi parametrami hematologicznymi u chorych na przewlekła białaczke szpikowa.