Testing of saliva and serum for HIV in high-risk populations. Ad Hoc Group for the Comparative Saliva and Serum Study.
Paired samples of saliva and serum from 286 high-risk subjects were tested for HIV using two commercial enzyme immunoassays following the same WHO testing strategy supplemented with a Western blot technique. Agreement between HIV testing in both sample types was 98.9% (95% confidence interval: 97.7-100). The sensitivity of an EIA (Wellcozyme GACELISA) alone for saliva was 100% (133/133) and the specificity 98.7% (151/153). These results support previous data showing that in some situations saliva might be an effective alternative to serum for HIV testing.
Vall Mayans
M
M
AIDS Programme, Department of Health, Generalitat de Catalunya, Barcelona, Spain.
Casabona
J
J
Rabella
N
N
De Miniac
D
D
D015492:AIDS Serodiagnosis / Q000379:methods*; D000328:Adult; D015153:Blotting, Western; D016001:Confidence Intervals; D005260:Female; D015483:HIV Antibodies / Q000032:analysis*; D015658:HIV Infections / Q000175:diagnosis*; D015528:HIV Seroprevalence; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D012463:Saliva / Q000821:virology*; D012680:Sensitivity and Specificity
D015483:HIV Antibodies