title: [A clinical-pharmacological case (1). Action of cisapride (Prepulsid) on bladder function].
abstract: We report the case of a 75 old man with chronic constipation due to traumatic spinal cord injury 25 years ago. Following prostatectomy the patient developed retention of urine and urinary incontinence, which improved significantly during a therapy with cisapride (3 x 10 mg/day). While the administration of cisapride is associated with increased detrusor activity and possibly urinary incontinence in neurologically normal persons, patients with urinary retention due to spinal cord injury may benefit from a therapy with this indirect parasympathomimetic agent.
authors.affiliation: Departement Innere Medizin, Abteilung Klinische Pharmakologie, Universitätsspital Zürich.
authors.forename: C
authors.initials: C
authors.lastname: Meier
authors.forename: C
authors.initials: C
authors.lastname: Hess
authors.forename: P J
authors.initials: PJ
authors.lastname: Meier-Abt
authors.forename: S
authors.initials: S
authors.lastname: Krähenbühl
mesh_terms: D000368:Aged; D020117:Cisapride; D003248:Constipation / Q000209:etiology; D006801:Humans; D008297:Male; D010277:Parasympathomimetics / Q000627:therapeutic use*; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications*; D016055:Urinary Retention / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D010277:Parasympathomimetics; D010880:Piperidines; D020117:Cisapride
vernacular_title: Der klinisch-pharmakologische Fall (1). Wirkung von Cisaprid (Prepulsid) auf die Harnblasenfunktion.