title: Stachybocins, novel endothelin receptor antagonists, produced by Stachybotrys sp. M6222. II. Structure determination of stachybocins A, B and C.
abstract: The structures of stachybocins A, B and C, new endothelin receptor antagonist, were determined by NMR spectral analysis using pulse-field-gradient technique. Stachybocin A consists of two spirobenzofuran units each fused to a substituted decalin, which were connected by a lysine residue. Stachybocins B and C are derivatives of stachybocin A with an additional hydroxy group at the same position in the different decalin unit.
authors.affiliation: Institute for Life Science Research, Asahi Chemical Industry Co. Ltd, Shizuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Yaginuma
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: K
authors.initials: K
authors.lastname: Shin-Ya
authors.forename: H
authors.initials: H
authors.lastname: Seta
mesh_terms: D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology; D002247:Carbon Isotopes; D065128:Endothelin Receptor Antagonists; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology; D013191:Stachybotrys / Q000378:metabolism*; D014316:Tritium
chemical_list: D001572:Benzofurans; D002247:Carbon Isotopes; D065128:Endothelin Receptor Antagonists; D013141:Spiro Compounds; C097789:stachybocin A; C097790:stachybocin B; C097791:stachybocin C; D014316:Tritium