title: Analysis of left atrioventricular plane movement during diastole in ischemic heart disease.
abstract: The aim of the present study was to investigate the properties of diastolic left atrioventricular plane displacement (AVPD) in coronary artery disease (CAD) patients. In 125 patients (mean age 58.7 +/- 13.7) with CAD and in 51 age-matched healthy subjects, a complete transthoracic echocardiographic study was performed. The AVPD was recorded by M-mode echocardiography, from apical four and two chamber views at four sites corresponding to the septal, lateral, anterior and inferior walls of the left ventricle. Mean AVPD in early diastole (E-AVPD), mean AVPD from atrial systole (A-AVPD) and the ratio A-AVPD/E-AVPD were determined. In normal subjects, such as in 35 patients without left ventricular segmental wall motion abnormalities (SWMA), stepwise multiple regression analysis showed none of these factors to be significantly related to E-AVPD or A-AVPD. Aging was correlated negatively to the E-AVPD/A-AVPD ratio (p < 0.05). In 90 patients with left ventricular SWMA, stepwise multiple regression analysis showed that indices of left ventricular systolic function correlated positively to E-AVPD (p < 0.001) and A-AVPD (p < 0.001). The E-AVPD/A-AVPD ratio was correlated to left ventricular ejection fraction and heart rate (p < 0.005). Mean E-AVPD was significantly lower in CAD patients than in normal subjects (p 0.001), while A-AVPD was higher in patients without left ventricular SWMA in comparison to normal subjects (p = 0.02). Also, mean A-AVPD/E-AVPD was higher in CAD patients than in the control group (p < 0.001). Mean E-AVPD/A-AVPD was correlated to the E/A ratio of transmitral flow in CAD patients with (r = 0.669) and without (r = 0.771) SWMA. The E-AVPD and A-AVPD in CAD patients with SWMA is reduced according to the deterioration of left ventricular systolic function. The atrial contribution to the longitudinal distension of the left ventricle is increased in CAD patients. In CAD patients, especially those without left ventricular SWMA, the E-AVPD/A-AVPD ratio has a good correlation to left ventricular filling behavior.
authors.affiliation: First Department of Cardiology, Evangelismos Hospital, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Kranidis
authors.forename: K
authors.initials: K
authors.lastname: Kostopoulos
authors.forename: G
authors.initials: G
authors.lastname: Filippatos
authors.forename: J
authors.initials: J
authors.lastname: Antonelis
authors.forename: K
authors.initials: K
authors.lastname: Kappos
authors.forename: F
authors.initials: F
authors.lastname: Kardaras
authors.forename: N
authors.initials: N
authors.lastname: Margaris
authors.forename: A
authors.initials: A
authors.lastname: Sideris
authors.forename: P
authors.initials: P
authors.lastname: Amartolos
authors.forename: G
authors.initials: G
authors.lastname: Kritharidou
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012044:Regression Analysis; D016277:Ventricular Function, Left