title: Healing of experimentally created defects: a review.
abstract: Within cranio-maxillofacial surgery and orthopedic surgery a bone graft or a bone substitute is required to recontour or assist bony healing in repair of osseous congenital deformities, or in repair of deformity due to trauma or to surgical excision after elimination of osseous disease processes exceeding a certain size. An autogenous bone graft is the optimal material of choice, however its use is problematic due to donor site morbidity, sparse amounts and uncontrolled resorption. Immunological responses and risk of viral contamination of allogenous and xenogenous bone materials make the use of these materials questionable. Healing and degradation of alloplastic materials are inconsistent with subsequent restricted use. The principle of guided tissue regeneration excluding soft tissue cells from a certain area is not alone sufficient to insure complete bony healing. Recombinant bone morphogenetic proteins have with success been added as adjuncts to already known biomaterials. In the future, inductive materials together with a suitable carrier and a biodegradable membrane may be the choice of bone substitute used within cranio-maxillofacial and orthopaedic surgery.
authors.affiliation: Department of Oral and Maxillofacial, University of Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Aaboe
authors.forename: E M
authors.initials: EM
authors.lastname: Pinholt
authors.forename: E
authors.initials: E
authors.lastname: Hjørting-Hansen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001847:Bone Diseases / Q000503:physiopathology* / Q000601:surgery; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods; D005147:Facial Bones / Q000503:physiopathology; D006133:Growth Substances / Q000627:therapeutic use; D048091:Guided Tissue Regeneration; D006801:Humans; D011506:Proteins / Q000627:therapeutic use; D011994:Recombinant Proteins; D012886:Skull / Q000503:physiopathology; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D006133:Growth Substances; D011506:Proteins; D011994:Recombinant Proteins