title: The effects of protective occlusive gloves on stratum corneum barrier properties.
abstract: Data suggests that protection from gloves is paradoxically reduced because of effects of occlusion on the skin. The aim of this study was to characterize these effects on physical and functional properties of stratum corneum. Volunteer trials were conducted using patches of polyvinyl chloride (PVC) glove material on the skin. Impairment of barrier function was assessed by measuring transepidermal water loss (TEWL). Hydration and water sorption-desorption was assessed using skin conductance. The major finding was a short-term impairment of barrier function, measured as an increase in TEWL of 1.7 gn-2h-1 (95% C.I. 0.4 to 2.6 gn-2h-1,p < 0.01). Temporary increases in hydration and water sorption were also observed. On this basis, the effects of wearing PVC gloves over 2 days on stratum corneum barrier properties on the dorsum of the hand were studied. TEWL measurements remained elevated by 1.5 gn-2h-1 the day after occlusive glove removal (95% C.I. 0.2 to 2.8 gn-2h-1, p < 0.01), indicating a possible cumulative effect. In conclusion, our studies demonstrate a potential hazard resulting from the repeated use of protective gloves.
authors.affiliation: Department of Dermatology, University of Wales College of Medicine, Cardiff, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Graves
authors.forename: C
authors.initials: C
authors.lastname: Edwards
authors.forename: R
authors.initials: R
authors.lastname: Marks
mesh_terms: D000328:Adult; D016001:Confidence Intervals; D004817:Epidermis / Q000502:physiology*; D005260:Female; D017575:Gloves, Protective; D006801:Humans; D008297:Male; D010328:Patch Tests; D010539:Permeability; D011143:Polyvinyl Chloride; D012879:Skin Physiological Phenomena; D013997:Time Factors; D014870:Water Loss, Insensible / Q000502:physiology
chemical_list: D011143:Polyvinyl Chloride