Adenovirus vectors as recombinant viral vaccines.
Adenoviruses can efficiently induce immunity in the lung following single enteric delivery. These viruses can also be engineered to express a number of heterologous proteins in vitro. In the past 10 years, recombinant adenoviruses expressing a variety of antigens have been constructed and tested. This article reviews the main properties of adenoviruses which render them attractive for vaccine development, as well as the results of the immunization studies performed to date. Some disadvantages of this technology and the desired characteristics of second generation adenoviral vectors are discussed.
Imler
J L
JL
Department of Gene Therapy, Transgène S.A., Strasbourg, France.
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D002986:Clinical Trials as Topic; D005816:Genetic Complementation Test; D005822:Genetic Vectors; D006801:Humans; D007114:Immunization; D014614:Vaccines, Synthetic / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*; D014779:Virus Replication
D014614:Vaccines, Synthetic; D014765:Viral Vaccines