title: Quantitative electroencephalographic analyses in cocaine-preferring polysubstance abusers during abstinence.
abstract: Quantitative electroencephalographic (QEEG) analyses are presented for a group of 90 subjects recovering from polysubstance abuse (median = 90 days abstinent) who preferentially used cocaine. QEEGs showed significant decreases from normal in both absolute and relative delta power and decreased theta power in both absolute and relative power. Significantly increased relative but not absolute alpha and beta power was found. Asymmetry of frontal delta, theta, and alpha power differed from normal with right power greater than left. Globally, reduced interhemispheric coherence was found in delta and theta bands and frontally in the beta band. An atypical EEG pattern was observed in about half of the subjects. This was a paroxysmal-like EEG alpha pattern reminiscent of vertex waves typically associated with drowsiness but lacking the waxing and waning of alpha and the slow lateral eye drift associated with drowsiness.
authors.affiliation: Department of Psychiatry, Temple University Health Sciences Center, Philadelphia, PA 19140, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Roemer
authors.forename: A
authors.initials: A
authors.lastname: Cornwell
authors.forename: D
authors.initials: D
authors.lastname: Dewart
authors.forename: P
authors.initials: P
authors.lastname: Jackson
authors.forename: D V
authors.initials: DV
authors.lastname: Ercegovac
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000503:physiopathology / Q000534:rehabilitation; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003042:Cocaine / Q000009:adverse effects*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects*; D008297:Male; D002189:Marijuana Abuse / Q000503:physiopathology / Q000534:rehabilitation; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012815:Signal Processing, Computer-Assisted; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000503:physiopathology* / Q000534:rehabilitation
chemical_list: D013287:Illicit Drugs; D011619:Psychotropic Drugs; D003042:Cocaine