Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene.
The two enteropathogens Yersinia pseudotuberculosis and Yersinia enterocolitica penetrate eukaryotic cells in vitro through invasin, a surface-exposed protein. In contrast, Yersinia pestis, the causative agent of plague, is unable to enter mammalian cell lines, although the inv gene is present on its chromosome. Although 99.3% identical to the inv gene of Y. pseudotuberculosis, the Y. pestis inv gene was disrupted in its central region by a 708-bp IS200-like element. Multiple copies of this insertion sequence element were found within the genome of the plague bacillus.
Simonet
M
M
INSERM U-411, Faculté de Médecine Necker, Paris, France.
Riot
B
B
Fortineau
N
N
Berche
P
P
D018829:Adhesins, Bacterial; D000595:Amino Acid Sequence; D001422:Bacterial Adhesion / Q000235:genetics; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D004251:DNA Transposable Elements; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D015010:Yersinia pestis / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; C053476:invasin, Yersinia