title: Evaluation of the pharmacokinetic interaction between cimetidine or famotidine and cyclosporine in healthy men.
abstract: OBJECTIVE
  To investigate the potential interaction between cimetidine or famotidine and cyclosporine in healthy men.
  
  
  METHODS
  All subjects received oral cyclosporine at baseline, after the first week of 1 histamine2 (H2)-blocker, and a third time after a 1-week washout plus 1 week of the second H2-blocker. Blood samples were collected just before each dose of cyclosporine and for up to 36 hours afterward for pharmacokinetic analysis.
  
  
  METHODS
  A college of pharmacy in a university teaching hospital.
  
  
  METHODS
  The study population consisted of 8 healthy men at least 19 years of age.
  
  
  METHODS
  Cyclosporine concentrations in whole blood were measured using a polyclonal fluorescence polarization immunoassay. Cyclosporine pharmacokinetic parameters during each of the 3 treatment periods were compared.
  
  
  RESULTS
  The average times to maximum cyclosporine concentrations were similar between baseline (3.2 h), cimetidine (2.9 h), and famotidine (3.6 h) dosing periods. There were no significant differences in area under the curve, half-life, or maximum concentration during the 3 dosing periods.
  
  
  CONCLUSIONS
  Neither cimetidine or famotidine produced a significant change in the pharmacokinetics of single-dose oral cyclosporine in healthy men.
authors.affiliation: College of Pharmacy, University of Nebraska Medical Center, Omaha, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Shaefer
authors.forename: S J
authors.initials: SJ
authors.lastname: Rossi
authors.forename: T R
authors.initials: TR
authors.lastname: McGuire
authors.forename: L J
authors.initials: LJ
authors.lastname: Schaaf
authors.forename: D S
authors.initials: DS
authors.lastname: Collier
authors.forename: R J
authors.initials: RJ
authors.lastname: Stratta
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D018592:Cross-Over Studies; D016572:Cyclosporine / Q000493:pharmacokinetics*; D004347:Drug Interactions; D015738:Famotidine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006785:Hospitals, University; D006801:Humans; D008297:Male
chemical_list: D006635:Histamine H2 Antagonists; D015738:Famotidine; D002927:Cimetidine; D016572:Cyclosporine