Increased c-fos expression associated with hyperthermia-induced apoptosis of a Burkitt lymphoma cell line.
Hyperthermia (42 - 44 degrees C for 30 min to 1 h) can induce apoptosis in a variety of cell types and tumour cell lines. This process is usually, but not invariably unaffected by RNA and protein synthesis inhibition. C-fos expression has been implicated in the regulation of apoptosis occurring under diverse circumstances. By heating the Burkitt lymphoma cell line, BM 13674, for 43 degrees C for 30 min, approximately 60% of cells underwent apoptosis within 6h of treatment. Co-ordinate with the massive induction of apoptosis, a 10-fold increase in the steady state c-fos mRNA expression occurred.
Cummings
M
M
Department of Pathology, University of Queensland Medical School, Herston, Australia.
D017209:Apoptosis; D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000235:genetics / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D016762:Genes, fos / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger