[The amino acid pool of the liver during activation of glutathione synthesis].
Regularities of formation of a pool of free amino acids and their derivatives in the liver of rats were studied during L-2-oxothiazoidin-4-carboxylate-induced glutathione synthesis activation. It was shown that an increase in concentrations of sulfur-containing (cysteate, cysteine) and branched-chain (valine, isoleucine, leucine) amino acids was the most typical change. The correlation and linear-discriminant analysis of the whole range of the compounds studied in the dynamics of the experimental process has proved high informativeness of glycogenic amino acid levels, activation of the whole chain of synthesis and degradation of thiol-containing amino acids as well as determination of the obtained shifts in concentrations of reduced glutathione.
Nefedov
L I
LI
Doroshenko
E M
EM
Khomich
T N
TN
Klimovich
I I
II
Smirnov
V Iu
VIu
Zav'ialova
G N
GN
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D003544:Cysteic Acid / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism*; D016002:Discriminant Analysis; D005260:Female; D005978:Glutathione / Q000096:biosynthesis*; D007532:Isoleucine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011761:Pyrrolidonecarboxylic Acid; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D013844:Thiazoles; D053778:Thiazolidines; D007532:Isoleucine; D003544:Cysteic Acid; D005978:Glutathione; D007930:Leucine; D014633:Valine; D003545:Cysteine; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid
Aminokislotnyĭ fond pecheni na fone aktivatsii sinteza glutationa.