title: Short-term effects of captopril (Katopil) on renal haemodynamics and function in hypertensive patients.
abstract: Short-term effects of captopril on the renal-hemodynamics and function were evaluated in 75 adult hypertensive patients. The behaviour of total and divided effective renal plasma flows (ERPF) and parenchymal mean transit time (PaMTT) implied three types of effect the premedication exerted on local renal haemodynamics and function: a protective one, no significant changes and an adverse one. In the vast majority of the cases captopril induced reduction in systemic blood pressure, was observed, irrespective of the renal response. The methodology presented seems to be a sensitive test for the selection of patients in whom an overall beneficial effect from the therapy with captopril monotherapy is expected.
authors.affiliation: Department of Pathophysiology, Medical Faculty, Novi Sad.
authors.forename: V
authors.initials: V
authors.lastname: Sedlak-Vadoc
authors.forename: M
authors.initials: M
authors.lastname: Petrović
authors.forename: M
authors.initials: M
authors.lastname: Ubavić
authors.forename: Z
authors.initials: Z
authors.lastname: Stosić
authors.forename: D
authors.initials: D
authors.lastname: Atanacković
mesh_terms: D000328:Adult; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D007668:Kidney / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012079:Renal Circulation / Q000187:drug effects*; D017263:Technetium Tc 99m Mertiatide
chemical_list: D017263:Technetium Tc 99m Mertiatide; D002216:Captopril