title: Mitigating the effects of halofuginone on skin strength by feeding L-proline to broiler chickens.
abstract: Two experiments were conducted to determine whether supplemental levels of L-proline in the diets of broiler chickens would mitigate the skin weakening effect caused by continuous feeding of the anticoccidial halofuginone. In Experiment 1, tensile strength and collagen levels in thigh apteria skin were determined at 21 and 42 d of age in male broilers fed 0, .5, and 1% L-proline with either halofuginone (3 mg/kg) or salinomycin (61 mg/kg). In Experiment 2, the same measurements were made on female broilers receiving diets containing halofuginone and supplemented with 0, .5, or 1% L-proline, 1% L-proline through 21 d of age, or 1% L-glutamic acid through 21 d of age, or a diet containing high L-proline feedstuffs (corn gluten meal and ring dried blood meal). In Experiment 1, dermis thickness of thigh apteria was measured in the males at Day 21. Skin strength was increased in male and female broilers fed halofuginone with addition of .5 and 1% L-proline, respectively, at 21 and 42 d of age. Continuous incorporation of synthetic L-proline into diets was shown to improve skin strength in females, whereas diets formulated to contain high levels of L-proline from feedstuffs, 21-d feeding of L-proline, or L-glutamic acid did not increase skin strength.
authors.affiliation: Washington State University, Puyallup Research and Extension Center 98371-4998, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Christensen
authors.forename: N G
authors.initials: NG
authors.lastname: Zimmermann
authors.forename: C L
authors.initials: CL
authors.lastname: Wyatt
authors.forename: T N
authors.initials: TN
authors.lastname: Goodman
authors.forename: R J
authors.initials: RJ
authors.lastname: Buhr
authors.forename: P F
authors.initials: PF
authors.lastname: Twining
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D003049:Coccidiostats / Q000008:administration & dosage / Q000009:adverse effects*; D003094:Collagen / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005527:Food, Fortified; D008297:Male; D010880:Piperidines; D011392:Proline / Q000008:administration & dosage / Q000494:pharmacology*; D011799:Quinazolines / Q000008:administration & dosage / Q000009:adverse effects*; D052999:Quinazolinones; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012879:Skin Physiological Phenomena; D013718:Tensile Strength / Q000187:drug effects*
chemical_list: D003049:Coccidiostats; D010880:Piperidines; D011799:Quinazolines; D052999:Quinazolinones; D003094:Collagen; D011392:Proline; C010176:halofuginone