The effect of vasopressin analogue [d(CH2)5(1),Tyr(Me)2]AVP on memory process in rats with experimental amnesia.
We investigated the effect of a single 2 micrograms dose of vasopressin (AVP) analogue [(CH2)5(1),Tyr(Me)2]AVP on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia. The models used were: electroconvulsive shock (ECS) and hypoxia. It severely impaired the memory processes. The AVP analogue [d(CH2)5(1),Tyr(Me)2]AVP facilitated retrieval of passive avoidance in all animals.
Car
H
H
Department of Pharmacology, Medical Academy, Białystok, Poland.
Borawska
M
M
Wiśniewski
K
K
D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D004597:Electroshock; D002534:Hypoxia, Brain / Q000523:psychology; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar
D001127:Arginine Vasopressin; C025044:argipressin, beta-mercapto-beta,beta cyclopentamethylenepropionic acid(1)-