title: Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?
abstract: Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events.
authors.affiliation: Oxford Regional Genetics Service, Oxford Radcliffe Trust, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Hurst
authors.forename: R S
authors.initials: RS
authors.lastname: Houlston
authors.forename: A
authors.initials: A
authors.lastname: Roberts
authors.forename: S J
authors.initials: SJ
authors.lastname: Gould
authors.forename: W G
authors.initials: WG
authors.lastname: Tingey
mesh_terms: D000014:Abnormalities, Drug-Induced; D000328:Adult; D002675:Child, Preschool; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005333:Fetus / Q000002:abnormalities; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000473:pathology*; D007741:Labetalol / Q000009:adverse effects; D017880:Limb Deformities, Congenital; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000009:adverse effects; D011247:Pregnancy
chemical_list: D007741:Labetalol; D011224:Prazosin