Cyclosporine-associated mutism in liver transplant patients.
Four liver transplant recipients treated with cyclosporine developed a reversible neurologic syndrome characterized by a speech disorder leading to mutism. This complication, previously reported in a few liver transplant recipients treated with the immunosuppressive drug FK506, had not been described with cyclosporine. Recognition of this syndrome should prompt withdrawal of the drug and avoidance of unnecessary diagnostic procedures.
Valldeoriola
F
F
Service of Neurology, Hospital Clínic i Provincial, Barcelona, Spain.
Graus
F
F
Rimola
A
A
Andreu
H
H
Santamaria
J
J
Catafau
A
A
Visa
J
J
Tolosa
E
E
Rodés
J
J
D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009155:Mutism / Q000139:chemically induced*
D016572:Cyclosporine