Activated protein C sensitivity ratio in pregnant women at delivery.
We studied activated protein C sensitivity ratio (APC-SR), factors V and VIII activity and von Willebrand antigen in control women, women using oral contraceptives, and pregnant women at delivery. The mean APC-SR of 2.4 in pregnant women was significantly lower than the mean APC-SR value of 3.5 for both the other groups and 45% of pregnant women had a ratio below the 5th percentile of the control group. None of them carried the R506-->Q mutation. This decreased ratio at delivery appeared to be connected, at least in part, with increased VIII activity. Thus, APC-SR at delivery should not be used to detect APC resistance.
Mathonnet
F
F
Laboratoire de Biologie, CHI de Poissy, Université Paris V, INSERM CJF 94-02, Poissy, France.
de Mazancourt
P
P
Bastenaire
B
B
Morot
M
M
Benattar
N
N
Beufé
S
S
Borg
J Y
JY
Giudicelli
Y
Y
D000328:Adult; D001777:Blood Coagulation; D003276:Contraceptives, Oral / Q000494:pharmacology*; D036861:Delivery, Obstetric; D005165:Factor V / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011486:Protein C / Q000502:physiology*; D014841:von Willebrand Factor / Q000378:metabolism
D003276:Contraceptives, Oral; D011486:Protein C; D014841:von Willebrand Factor; D005165:Factor V; D005169:Factor VIII