The giant cell fibroma. A review of 103 cases with immunohistochemical findings.
This article reports a series of 103 cases of giant cell fibromas occurring in the oral mucosa. The commonest location was the gingiva, followed by the tongue and the buccal mucosa. The mean age of the patients was 27.7 years, and the median age 21 years. Microscopically, the tumors were characterized by the presence of large stellate or angular cells, which occasionally contained several nuclei. Immunohistochemical stains showed that the cells were vimentin-positive but negative for S-100 protein, cytokeratin, leukocyte common antigen, and neurofilament.
Magnusson
B C
BC
Department of Oral Pathology, Faculty of Odontology, Göteborg University, Sweden.
Rasmusson
L G
LG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D005260:Female; D005350:Fibroma / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D005887:Gingival Neoplasms / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D016900:Neurofilament Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D016900:Neurofilament Proteins; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins; D017493:Leukocyte Common Antigens