title: Hearing loss in Paget's disease of bone: evidence of auditory nerve integrity.
abstract: Auditory brainstem responses (ABRs) were recorded in 64 ears with radiographically confirmed Paget's disease involving the skull. Responses were absent in eight ears, all of which had elevated high pure-tone thresholds. Auditory brainstem responses were interpreted as normal in 56 ears; none were abnormal. Computed tomography and digital image analysis were used to quantify internal auditory canal (IAC) dimensions. The midlength diameter and minimum diameter of the IAC of 68 temporal bones from subjects with Paget's disease were found to have no statistically significant relation to hearing thresholds. Increased IAC length showed a limited relation to reduced hearing level in pagetic subjects, possibly consistent with bossing adjacent to the porus acusticus. Findings support the principle that hearing loss in Paget's disease of bone is generally associated with intact auditory nerve function and also support a cochlear site of lesion.
authors.affiliation: Department of Otolaryngology--Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Monsell
authors.forename: H G
authors.initials: HG
authors.lastname: Bone
authors.forename: D D
authors.initials: DD
authors.lastname: Cody
authors.forename: G P
authors.initials: GP
authors.lastname: Jacobson
authors.forename: C W
authors.initials: CW
authors.lastname: Newman
authors.forename: S C
authors.initials: SC
authors.lastname: Patel
authors.forename: G W
authors.initials: GW
authors.lastname: Divine
mesh_terms: D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D016057:Evoked Potentials, Auditory, Brain Stem; D007839:Functional Laterality; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D010001:Osteitis Deformans / Q000150:complications*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D000159:Vestibulocochlear Nerve / Q000502:physiology*