title: [Duplex sonographic studies on the pathogenesis of splenic hemodynamics in liver cirrhosis].
abstract: OBJECTIVE
  The haemodynamic role of the spleen in portal hypertension remains unclear. Duplex sonography was undertaken prospectively to discover the relationship of splenomegaly and splenic vein flow to type and severity of liver cirrhosis and portal vein flow, as well as to the degree of oesophageal varices.
  
  
  METHODS
  89 patients (54 men, 35 women; mean age 52 [26-81] years), diagnosed in the second half of 1993 as having liver cirrhosis were consecutively included in the study. In 40 patients the cirrhosis was in stage A (according to Child-Pugh classification), in 31 in stage B and in 18 in stage C.
  
  
  RESULTS
  Portal vein flow fell significantly with increasing degree of cirrhosis (stage A: 8.29 cm/s; stage B 7.03 cm/s; stage C 5.26 cm/s; P < 0.05). Splenic vein flow differed significantly only between stages B and C (stage A: 9.22 cm/s; stage B: 9.46 cm/s; stage C: 7.87 cm/s; B vs C, P < 0.05). There was no correlation between portal vein flow, splenic vein flow, degree of splenomegaly and extent of oesophageal varices.
  
  
  CONCLUSIONS
  The results may be explained by the presence of collateral circulations and by the differing pathophysiological part played by the spleen in liver cirrhosis of different aetiologies.
authors.affiliation: Medizinische Klinik und Poliklinik, Universität Mainz.
authors.forename: H
authors.initials: H
authors.lastname: Mohr
authors.forename: W
authors.initials: W
authors.lastname: Gödderz
authors.forename: A
authors.initials: A
authors.lastname: Grosse
authors.forename: G
authors.initials: G
authors.lastname: Gerken
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D016145:Endoscopy, Digestive System; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013154:Spleen / Q000098:blood supply / Q000000981:diagnostic imaging*; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D018709:Statistics, Nonparametric; D018616:Ultrasonography, Doppler, Duplex / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data
vernacular_title: Duplexsonographische Untersuchungen zur Pathogenese der lienalen Hämodynamik bei Leberzirrhose.