Monamidocin, a novel fibrinogen receptor antagonist. I. Production isolation, characterization and structural elucidation.
Monamidocin, a novel fibrinogen receptor antagonist, has been isolated from the culture broth of Streptomyces sp. NR 0637 BY carbon adsorption, n-BuOH extraction, SP-Toyopearl, silica gel 60 silanised and Sephadex LH-20 column chromatographies and preparative HPLC. The molecular formula of monamidocin has been determined to be C15H22N4O4 from HRFAB-MS and 13C NMR spectral data. The structure of monamidocin has been determined to be N-[(S)-5-guanidino-2-hydroxypentanoyl]-L-phenylalanine by 2D NMR experiments.
Kamiyama
T
T
Nippon Roche Research Center, Kamakura, Japan.
Umino
T
T
Itezono
Y
Y
Anzai
Y
Y
Nakayama
N
N
Takemae
A
A
Satoh
T
T
Watanabe
J
J
Yokose
K
K
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D017077:Culture Media, Conditioned; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013302:Streptomyces / Q000378:metabolism*
D017077:Culture Media, Conditioned; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C097815:monamidocin; D010649:Phenylalanine