Malabsorption and villous atrophy in patients receiving enteral feeding.
BACKGROUND
The purpose of this study was to assess the structure and function of the small intestine before and after enteral feeding given via a percutaneous feeding gastrostomy (PEG). It is not known whether this method of feeding provides a good luminal drive to the small intestine.


METHODS
Studies were performed of patients at the time of PEG placement, in a cross-sectional group after a period of feeding and in a smaller longitudinal subgroup. Enteral feeds were adjusted in volume and caloric content for each patient. Duodenal biopsies were taken during endoscopy for quantitative morphometry, and lactulose-rhamnose permeability tests were performed during the next day. Duodenal fluid was cultured quantitatively in the first study, and disaccharidases determined in the second study.


RESULTS
The first study of 15 patients, who had enteral feeding for a median (range) period of 13 (8 to 104) weeks, showed partial villous atrophy with normal crypt length, no increase in duodenal bacteriology, and abnormal lactulose-rhamnose sugar permeability due to rhamnose malabsorption. These changes were also present in 38 similar patients before enteral feeding. A second study before enteral feeding showed lowered maltase activity (24 patients), and similar intestinal permeability findings (22 patients). Twelve of these patients were followed longitudinally for 3 months of enteral feeding that maintained but did not improve nutrition, as assessed by body mass index and mid-arm muscle circumference, and there was no change in duodenal morphometry (11 patients), rhamnose malabsorption (4 patients), or disaccharidases (11 patients).


CONCLUSIONS
These studies suggest villous atrophy was not due to an inflammatory enteropathy but resulted from a poor luminal "drive" associated with the enteral feeding. Enteral feeding maintained but did not improve nutrition status.
Cummins
A
A
Gastroenterology Unit, Queen Elizabeth Hospital, Woodville South, South Australia.
Chu
G
G
Faust
L
L
Chandy
G
G
Argyrides
J
J
Robb
T
T
Wilson
P
P
D001284:Atrophy; D003430:Cross-Sectional Studies; D004386:Duodenum / Q000382:microbiology / Q000473:pathology; D004750:Enteral Nutrition / Q000009:adverse effects*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D007792:Lactulose / Q000378:metabolism; D008137:Longitudinal Studies; D008286:Malabsorption Syndromes / Q000209:etiology*; D009747:Nutritional Physiological Phenomena; D012210:Rhamnose / Q000378:metabolism; D013997:Time Factors; D000520:alpha-Glucosidases / Q000378:metabolism
D007792:Lactulose; D000520:alpha-Glucosidases; D012210:Rhamnose