Invasive Haemophilus influenzae type b infection in a child with familial deficiency of the beta subunit of the eighth component of complement.
A child who had had meningitis caused by Haemophilus influenzae type b, and then had meningococcal meningitis, was found to have familial deficiency of the beta subunit of the eighth component of complement. The child had not received the H. influenzae type b vaccine. If this deficiency is discovered, we recommend that family members be screened, regardless of their health status.
Pallares
D E
DE
Department of Allergy and Immunology, Henry Ford Hospital, Detroit, Michigan, USA.
Figueroa
J E
JE
Densen
P
P
Giclas
P C
PC
Marshall
G S
GS
D003185:Complement C8 / Q000172:deficiency* / Q000235:genetics*; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology* / Q000382:microbiology; D006193:Haemophilus influenzae / Q000145:classification / Q000276:immunology; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000276:immunology* / Q000382:microbiology; D009345:Neisseria meningitidis / Q000276:immunology
D003185:Complement C8