title: Biosynthesis of factor IX: implications for gene therapy.
authors.affiliation: Center for Hemostasis and Thrombosis, New England Medical Center, Boston, MA 02111, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Furie
authors.forename: B
authors.initials: B
authors.lastname: Furie
mesh_terms: D000595:Amino Acid Sequence; D019735:Carbon-Carbon Ligases; D004721:Endoplasmic Reticulum / Q000201:enzymology; D004789:Enzyme Activation; D005164:Factor IX / Q000096:biosynthesis* / Q000235:genetics; D015949:Factor IXa / Q000502:physiology; D015316:Genetic Therapy; D006031:Glycosylation; D002836:Hemophilia B / Q000235:genetics / Q000628:therapy*; D006801:Humans; D006900:Hydroxylation; D008025:Ligases / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals / Q000378:metabolism; D014812:Vitamin K / Q000378:metabolism
chemical_list: D011498:Protein Precursors; D021382:Protein Sorting Signals; D014812:Vitamin K; D005164:Factor IX; D015949:Factor IXa; D008025:Ligases; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase