IR and turbidity studies of vitamin E-cholesterol-phospholipid membrane interactions.
Binary and tertiary mixture of alpha-tocophenol, cholesterol and dimyristoylphosphatidylcholine in the form of multilamellar liposomes were investigated by Fourier Transform Infrared and visible spectroscopy. Results of the FTIR and turbidity experiments indicate that alpha T decreases or diminishes the effect of cholesterol on the frequency and the bandwidth of the C-H stretching, CH2 scissoring and C = O stretching bands in FTIR spectra and the turbidity measurements (recorded as absorbance values at 440 nm) in phospholipid model membranes.
Severcan
F
F
Middle East Technical University, Department of Biological Sciences, Ankara, Turkey.
Kazanci
N
N
Baykal
U
U
Süzer
S
S
D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000494:pharmacology*; D004134:Dimyristoylphosphatidylcholine / Q000378:metabolism; D004347:Drug Interactions; D008081:Liposomes / Q000378:metabolism; D008563:Membrane Lipids / Q000494:pharmacology*; D009391:Nephelometry and Turbidimetry; D010743:Phospholipids / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D014810:Vitamin E / Q000494:pharmacology*
D008081:Liposomes; D008563:Membrane Lipids; D010743:Phospholipids; D014810:Vitamin E; D002784:Cholesterol; D004134:Dimyristoylphosphatidylcholine