title: YM-47141 and 47142, new elastase inhibitors produced by Flexibacter sp. Q17897. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
abstract: In the course of our screening for elastase inhibitors from microorganism, we have found two new cyclic-depsipeptides designated YM-47141 and 47142. In this paper, we described the taxonomy of the producing organism and isolation, physico-chemical properties, and biological activities of YM-47141 and 47142.
authors.affiliation: Drug Serendipity Research Laboratories, Institute for Drug Discovery Research, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yasumuro
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Shibazaki
authors.forename: K
authors.initials: K
authors.lastname: Teramura
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Orita
mesh_terms: D000818:Animals; D041963:Bacteroidetes / Q000145:classification / Q000378:metabolism*; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006801:Humans; D019272:Leukocyte Elastase; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D010456:Peptides, Cyclic; D015842:Serine Proteinase Inhibitors; C097796:YM 47141; C097797:YM 47142; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase