title: The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons.
abstract: We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca2+]i in NTera2-neurons. While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca2+]i, high concentrations of extracellular NAA (3, 10 mM) elicited sharp and statistically significant elevations of [Ca2+]i. Different classes of antagonists of the N-methyl-D-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca2+]i, indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca2+]i.
authors.affiliation: Radiology Department, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Rubin
authors.forename: M C
authors.initials: MC
authors.lastname: LaPlaca
authors.forename: D H
authors.initials: DH
authors.lastname: Smith
authors.forename: L E
authors.initials: LE
authors.lastname: Thibault
authors.forename: R E
authors.initials: RE
authors.lastname: Lenkinski
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009474:Neurons / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D013997:Time Factors
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D016291:Dizocilpine Maleate; C000179:N-acetylaspartate; D002118:Calcium