Effects of chromium and guar on sugar-induced hypertension in rats.
Ingestion of sugars (sucrose, fructose, glucose) by various rat strains is associated with perturbations in the glucose/insulin system and higher systolic blood pressure (SBP). The association suggests causality, because alterations in insulin metabolism have been found in essential hypertension and many experimental forms of hypertension. To test the hypothesis that sugar-induced SBP elevation is secondary to perturbed insulin metabolism, we examined in 2 experiments effects of chromium and guar, substances known to affect insulin metabolism, on SBP of Spontaneously Hypertensive Rats (SHR). In both studies, sucrose compared to starch ingestion caused significant elevation of SBP; but addition of 2 chromium nicotinate complexes and guar prevented development of sugar-induced SBP elevations. The basal, genetic hypertension of the SHR was not affected by either nutrient. An additional finding in the first study was that sugar-consuming SHR supplemented with chromium had greater BW and increased organ weight (kidney, spleen, and liver) than nonsupplemented SHR. Accordingly, we have shown that two different mechanisms known to ameliorate insulin perturbations, use of chromium and guar, prevent sugar-induced SBP elevations. Since essential hypertension may be due to insulin perturbations and high dose chromium supplementation seems nontoxic, this may prove to be a useful means to lower blood pressure (BP) in some essential hypertensives, as well as diabetic hypertensives. Soluble fiber in the form of guar is also quite effective in favorably influencing sugar-induced SBP elevations.
Preuss
H G
HG
Department of Medicine (Nephrology), Georgetown University Medical Center, Washington, DC 20007, USA.
Gondal
J A
JA
Bustos
E
E
Bushehri
N
N
Lieberman
S
S
Bryden
N A
NA
Polansky
M M
MM
Anderson
R A
RA
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002241:Carbohydrates; D002857:Chromium / Q000494:pharmacology*; D004032:Diet; D005685:Galactans / Q000494:pharmacology*; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D053149:Plant Gums; D051381:Rats; D011918:Rats, Inbred SHR
D001786:Blood Glucose; D002241:Carbohydrates; D005685:Galactans; D007328:Insulin; D008055:Lipids; D008351:Mannans; D053149:Plant Gums; D002857:Chromium; C007894:guar gum