title: Long latency postural reflexes are under supraspinal dopaminergic control.
abstract: Scaling of posturally stabilizing long latency (LL) reflexes in tibialis anterior muscles induced by "toe-up" rotational perturbations is abnormal in standing patients with Parkinson's disease. To investigate the contribution of dopaminergic pathways to abnormal scaling, we studied LL reflexes in 22 patients with selective hypodopaminergic syndromes: 10 psychiatric patients taking chronic neuroleptic medication (7 with mild parkinsonism), 8 patients with young-onset Parkinson's disease, and 4 patients with MPTP-induced parkinsonism. Results were compared with those of 10 healthy controls. Stimuli consisted of (a) 10 serial (predictable) perturbations of 4 degrees amplitude, (b) 10 serial (predictable) perturbations of 10 degrees amplitude, and (c) 20 randomly mixed (unpredictable) perturbations of either 4 or 10 degrees amplitude. In normal subjects, LL reflex amplitudes were adapted to match predictable variations in stimulus size, whereas under unpredictable conditions a "default" response emerged that anticipated the 10 degrees perturbation. LL reflex scaling under predictable conditions was intact in patients with neuroleptic-induced parkinsonism and young-onset Parkinson's disease, but the large default LL response under unpredictable conditions was absent. In patients with MPTP-induced parkinsonism, LL reflex scaling was absent during both predictable and unpredictable conditions. We conclude that abnormal scaling of posturally stabilizing LL reflexes is related to decreased supraspinal dopaminergic influence.
authors.affiliation: Department of Neurology, University Hospital Leiden, The Netherlands.
authors.forename: B R
authors.initials: BR
authors.lastname: Bloem
authors.forename: D J
authors.initials: DJ
authors.lastname: Beckley
authors.forename: J P
authors.initials: JP
authors.lastname: van Vugt
authors.forename: J G
authors.initials: JG
authors.lastname: van Dijk
authors.forename: M P
authors.initials: MP
authors.lastname: Remler
authors.forename: J W
authors.initials: JW
authors.lastname: Langston
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000009:adverse effects; D000328:Adult; D017668:Age of Onset; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000172:deficiency / Q000378:metabolism*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal; D010300:Parkinson Disease / Q000188:drug therapy; D010302:Parkinson Disease, Secondary / Q000209:etiology; D011187:Posture; D012559:Schizophrenia / Q000188:drug therapy; D013378:Substantia Nigra / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine