title: Maternal age and gestational age-specific risk for chromosomal defects.
abstract: This study provides estimates of risks for a wide range of chromosomal defects taking into account maternal age as well as the gestation at assessment. The estimates make it possible to counsel patients presenting at different stages of pregnancy. At the same time, they offer the possibility of evaluating the efficacy of biochemical and ultrasonographic markers in identifying fetuses with chromosomal defects.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Snijders
authors.forename: N J
authors.initials: NJ
authors.lastname: Sebire
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000209:etiology; D025063:Chromosome Disorders; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis; D018570:Risk Assessment