[Pathomorphology of kidney lesions induced by non-steroidal anti-inflammatory drugs].
Pathomorphological findings on nephrobiopsies from two groups of patients with NSAID-induced kidney lesions are provided. In the first group (9 patients) the disease developed in patients of different age after short-term use of NSAID and was clinically manifested by acute renal failure with extrarenal allergic symptoms (skin, rash, eosinophilia). Morphological features were acute tubulo-interstitial nephritis without glomerular lesions. In the second group (23 patients) the disease developed after longterm use of NSAID in older patients with a compromised renal blood circulation presenting clinically with nephrotic syndrome, and morphologically by acute tubulo-interstitial nephritis with minimal change (lipoid nephrosis).
Postishil'
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D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001706:Biopsy; D004342:Drug Hypersensitivity / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology; D009402:Nephrosis, Lipoid / Q000473:pathology; D009404:Nephrotic Syndrome / Q000473:pathology; D012189:Retrospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal
Patomorfologiia porazheniĭ pochek, obuslovlennykh nesteroidnymi protivovosplaitel'nymi preparatmi.