title: [Combination of propofol-sufentanil on somatosensory evoked potentials in surgery of the spine].
abstract: OBJECTIVE
  Most anaesthetics depress cortical somatosensory evoked potentials (CSEPs). However, the modification of CSEPs during total intravenous anaesthesia using propofol remaining still unknown, justified this trial.
  
  
  METHODS
  Open, prospective, clinical study.
  
  
  METHODS
  Nine consecutive patients requiring CSEPs monitoring for spine surgery, were studied. Anaesthesia was induced with propofol (2.5 mg.kg-1 then 10 mg.kg-1.h-1) and sufentanil (0.50 micrograms.kg-1 then 0.25 micrograms.kg-1.h-1). Maximum positive (P40) and negative (N50) waweform latencies, and the peak to peak amplitude of CSEPs (posterior tibial nerve stimulation, cortical recording), were recorded before induction, 30 min, 1 and 2 h after induction, and at the end of surgery. Data are means +/- SD.
  
  
  RESULTS
  Duration of anaesthesia was 260 +/- 73 min. Propofol induced significant lengthening of CSEPS (P40: from 37 +/- 10 up to 41 +/- 11 ms; N50: from 45 +/- 11 up to 51 +/- 14 ms), and a significant decrease in amplitude (from 1.9 +/- 0.9 down to 0.8 +/- 0.4 microV), but these changes were stable from 30 min after the induction to the end of spine surgery. A motor response was obtained 29 +/- 14 min after the end of anaesthetic administration.
  
  
  CONCLUSIONS
  Total intravenous anaesthesia with propofol and sufentanil induces a small but stable lengthening of CSEPs latency and a stable decrease of its amplitude, which enable an appropriate monitoring of CSEPs during spine surgery.
authors.affiliation: Département d'Anesthésie-Réanimation, Groupe Hospitalier Pitié-Salpêtrière, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Borrissov
authors.forename: O
authors.initials: O
authors.lastname: Langeron
authors.forename: F
authors.initials: F
authors.lastname: Lille
authors.forename: A
authors.initials: A
authors.lastname: Gomola
authors.forename: G
authors.initials: G
authors.lastname: Saillant
authors.forename: B
authors.initials: B
authors.lastname: Riou
authors.forename: P
authors.initials: P
authors.lastname: Viars
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D013131:Spine / Q000601:surgery*; D017409:Sufentanil / Q000494:pharmacology*
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D017409:Sufentanil; D015742:Propofol
vernacular_title: Effets de l'association propofol-sufentanil sur les potentiels évoqués somesthésiques au cours de la chirurgie du rachis.