Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist.
Tolerance to delta 9-tetrahydrocannabinol (delta 9-THC) was produced in rats by twice daily injections (15 mg/kg i.p.) for 6.5 days. Administration of the cannabinoid antagonist SR141716A (i.p. or i.c.v.) induced a profound precipitated withdrawal syndrome in delta 9-THC-tolerant animals. The syndrome was characterized by a disorganized pattern of constantly changing brief sequences of motor behavior. Autonomic signs were not evident. THC-tolerant animals that were treated with vehicle remained quiet throughout the observation period.
Tsou
K
K
Department of Psychology, Brown University, Providence, RI 02912, USA.
Patrick
S L
SL
Walker
J M
JM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D013759:Dronabinol / Q000008:administration & dosage / Q000009:adverse effects*; D006213:Hallucinogens / Q000008:administration & dosage / Q000009:adverse effects*; D007274:Injections, Intraperitoneal; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000037:antagonists & inhibitors*; D000077285:Rimonabant; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000503:physiopathology; D014828:Vocalization, Animal / Q000187:drug effects
D006213:Hallucinogens; D010880:Piperidines; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D013759:Dronabinol; D000077285:Rimonabant