title: [Ambulatory blood pressure monitoring and clinical trials].
abstract: Ambulatory blood pressure monitoring (ABPM) is now widely used for the assessment of antihypertensive drugs. This procedure may be used in phase II studies in dose-ranging evaluations as well as in phase III in order to assess the drug efficacy in the patient's natural environment. The increase in the reproducibility related to the repetition of blood pressure measurements by ambulatory monitoring may improve the accuracy of the trial and minimize the numbers of subjects required. Placebo fails to lower ambulatory blood pressure in almost all studies. Nevertheless, placebo is always necessary in clinical studies with ABPM at least for the pre-inclusion phase and in order to study the peak-trough ratio. This ratio may be accurately assessed by ABPM. Finally, ABPM may be useful to rule out "white coat" responders, who are not really hypertensive patients.
authors.affiliation: Service de pharmacologie clinique, CHU hôpital Sud, Amiens.
authors.forename: M
authors.initials: M
authors.lastname: Andréjak
authors.forename: J M
authors.initials: JM
authors.lastname: Mallion
authors.forename: R
authors.initials: R
authors.lastname: Asmar
authors.forename: N G
authors.initials: NG
authors.lastname: Chau
authors.forename: R
authors.initials: R
authors.lastname: de Gaudemaris
authors.forename: M
authors.initials: M
authors.lastname: Drici
authors.forename: D
authors.initials: D
authors.lastname: Herpin
authors.forename: P
authors.initials: P
authors.lastname: Poncelet
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D018660:Blood Pressure Monitoring, Ambulatory / Q000706:statistics & numerical data; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003627:Data Interpretation, Statistical; D004608:Eligibility Determination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D018579:Patient Selection; D010919:Placebos; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D010919:Placebos
vernacular_title: Mesure ambulatoire de la pression artérielle et essais thérapeutiques.