[Regulation of the expression of HLA class I genes in human trophoblasts].
This article presents an overview of the more recent data dealing with the constitutive expression of classical HLA-A, -B, -C and nonclassical HLA-E, -F, -G class I genes in the different trophoblast cell subpopulations that constitute the materno-fetal interface during human pregnancy. Although transcribed, classical HLA class I genes are never expressed as membrane-bound products in any of the trophoblast cell subpopulations. On the contrary, HLA-G is expressed at the cell surface of extravillous cytotrophoblast cells from first trimester placenta, suggesting that it may play a role in the maternal tolerance against the fetal allograft. Molecular regulatory mechanisms that may control such differential expression of classical and nonclassical class I molecules, according to the cell type, state of differentiation and stage of gestation are also examined. They may operate at the levels of transcription (cis- and/or trans-acting mechanisms), translation and/or transport of HLA class I heavy chains to the cell surface.
Le Bouteiller
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Unité INSERM 395, CHU Purpan, Toulouse, France.
D005260:Female; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D014158:Transcription, Genetic; D014327:Trophoblasts / Q000502:physiology*; D000097625:HLA-E Antigens
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens
Régulation de l'expression des gènes HLA de classe I dans le trophoblaste humain.