[Ability of bone marrow cells to generate active forms of oxygen in C57Bl/6 and BALB/C mice and mutagenic effects of dioxidine].
Phorbol-myristate acetate- and opsonized zymosan-induced statistically significant differences were shown in the intensity of chemiluminescence occurring in the bone marrow cell suspension. The bone marrow cells from male BALB/c mice showed the most pronounced response to stimulation in the two cases. After 5-day administration of dioxidine (300 mg/kg), the number of the injured metaphases in the bone marrow from the examined animals was 43.6 +/- 2.2 and 23.8 +/- 1.9% in BALB/c and C57B1/6 mice, respectively, which provides evidence for marked strain-specific differences in the cytogenetic effect of this proxidative mutagen. The findings indicated that there was a relationship between the capacity of bone marrow cells of producing APA and the severity of cytogenetic lesions in these cells.
Guseva
N V
NV
Durnev
A D
AD
Seredenin
S B
SB
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D001854:Bone Marrow Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*; D011810:Quinoxalines / Q000633:toxicity*; D017382:Reactive Oxygen Species
D009153:Mutagens; D011810:Quinoxalines; D017382:Reactive Oxygen Species; C001077:dioxidine
Sposobnost' kletok kostnogo mozga k generatsii aktivnykh form kislorodau mysheĭ linii C57Bl/6 i BALB/C i mutagennye éffekty dioksidina.