[Helicobacter pylori eradication heals the duodenal ulcer. Randomized, simple, and controlled study with omeprazole].
60 patients with Helicobacter pylori (Hp) infection and duodenal ulcer (DU) were randomized to received either: I) Two weeks of bismuth subcitrate, metronidazole and amoxicillin (TG) or II) Omeprazole for four weeks (OG). Endoscopy and antral biopsies were done at entry and four weeks after treatment, control endoscopy was performed 2-4-8 and 12 weeks after inclusion in the trial. Healing was similar in both groups at two four weeks. At twelve weeks DU recurred in OG 65% vs 13.36% in TG and Hp infection was present. Our results showed that Hp eradication healed DU in a similar rate than Omeprazole providing further evidence of a causal link between Hp infection and duodenal ulcer.
Piñero
R
R
Servico de Gastroenterología, Hospital Vargas de Caracas, Instituto de Biomedicina MSAS.
Pacheco
M
M
Urrestarazu
M
M
Serrano
N
N
Olavarría
R
R
Poleo
J R
JR
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D004724:Endoscopy; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D011446:Prospective Studies; D012008:Recurrence; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin; C002791:bismuth tripotassium dicitrate; D009853:Omeprazole
La erradicación de Helicobacter pylori cicatriza la úlcera duodenal. Estudio aleatorio, sencillo, controlado con omeprazol.