title: Current strategies for the treatment of alcohol dependence in the United States.
abstract: Substantial progress has been reported in the treatment of patients with alcoholism in the United States. Studies that seek to identify the most appropriate form of therapy for alcohol-dependent patients have been an important part of this effort. Recognition that psychotherapy alone cannot help all patients who have alcoholism has led to interest in the use of pharmacotherapy. Recent research demonstrates that pharmacotherapy with the opioid receptor antagonists naltrexone and nalmefene helps prevent relapse in many alcohol-dependent patients.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: O'Malley
mesh_terms: D000436:Alcoholics Anonymous; D000437:Alcoholism / Q000523:psychology / Q000534:rehabilitation*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D009271:Naltrexone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014481:United States
chemical_list: D009292:Narcotic Antagonists; D009271:Naltrexone; C038981:nalmefene