[Respective value of glycated hemoglobin and fructosamine assays in the care of diabetes mellitus].
The monitoring of metabolic balance in diabetes mellitus involves the assay of cumulative markers of protein glycation. Glycated hemoglobin, particularly the major component HbA1c, and fructosamine, which reflects glycated plasma protein levels, are the most commonly used parameters. Nevertheless, their utilization is still under discussion with respect to methodologies used, as well as to their respective interest in clinical diabetology. This review shows current opinion concerning the analytical and physiopathological use of these biological indicators.
Bernard
M
M
Laboratoire central de biochimie, hôpital de la Pitié, Paris, France.
Bordas-Fonfrède
M
M
Grimaldi
A
A
Guillemin
C
C
Stahl
A
A
Leutenegger
M
M
Gillery
P
P
D002852:Chromatography, Ion Exchange; D003920:Diabetes Mellitus / Q000097:blood* / Q000517:prevention & control; D004587:Electrophoresis, Agar Gel; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis*; D017127:Glycation End Products, Advanced / Q000097:blood; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007158:Immunologic Techniques
D019270:Fructosamine; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006595:Hexosamines
Intérêts respectifs des dosages d'hémoglobine glyquée et de fructosamines dans la surveillance du diabète sucré.