An eye banking program for selecting donor corneas for surgical distribution.
Since fewer donated corneas have become available for surgery, we sought to chart the reasons to exclude them for surgical use over time. Those excluded from surgical use (1991-1994) were plotted using an algorithm based on the reasons for exclusion. Four general categories (universal contraindications [UC], national/local medical criteria [NLMC], serology, and morphology) yielded 13 possible areas. UC and NLMC exclusions for 1993-1994 were higher compared with 1991 and 1992 (p < 0.001). The proportion of corneas excluded for serological reasons decreased (p < 0.001) from 1991 to 1994. Exclusions due to morphology remained the same for all 4 years (p = NS). NLMC eliminate older donors but also exclude younger donors before the tissue reaches the eye bank (p > 0.001). Three of four of the youngest tissues ( < 30 years) are used for surgery, whereas one of five of the oldest ( > 70 years) is used. A quality control algorithm provides a heuristic and logical paradigm for noting changes from year to year. Heightened regulation has counteracted many gains in corneal donation fostered by favorable laws.
Farge
E J
EJ
Lions Eye Bank of Texas, Houston 77030, USA.
Cox
W G
WG
Khan
M M
MM
D000328:Adult; D000368:Aged; D000465:Algorithms; D003315:Cornea / Q000601:surgery*; D005125:Eye Banks / Q000592:standards* / Q000706:statistics & numerical data; D006801:Humans; D015948:Keratoplasty, Penetrating; D008875:Middle Aged; D011786:Quality Control; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data