title: Anticonvulsant activity of aryl and hetarylsulfonylhydrazones.
abstract: A series of aryl and hetarylsulfonylhydrazones of aromatic aldehydes were tested for acute toxicity and anticonvulsant activity in mice. Some of these compounds were effective in the MES, pentetrazol and strychnine tests. Thiophene derivatives were the most active terms of the series.
authors.affiliation: Departamento de Farmacología, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Darias
authors.forename: S
authors.initials: S
authors.lastname: Abdallah
authors.forename: L
authors.initials: L
authors.lastname: Delgado
authors.forename: S
authors.initials: S
authors.lastname: Vega
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D004597:Electroshock; D005260:Female; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D013331:Strychnine
chemical_list: D000927:Anticonvulsants; D006835:Hydrazones; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D013331:Strychnine; D010424:Pentobarbital; D010433:Pentylenetetrazole