Severe renal hypouricemia secondary to hyperbilirubinemia.
A 64-year-old man with alcoholic liver cirrhosis had a progressive decrease in the serum uric acid (UA) until it became undetectable, an increase renal UA clearance, mild glycosuria with normal serum glucose and a decrease in the tubular reabsorption of phosphate in association with cholestasis secondary to a gallbladder carcinoma. All these abnormalities returned to normal when the serum bilirubin levels decreased following surgical treatment. This clinical observation suggests that the reversible renal tubular transport defect was secondary to high levels of serum bilirubin.
Arranz-Caso
J A
JA
Servicio de Medicina Interna, Hospital Universitario Principe de Asturias, Facultad de Medicina, Universidad de Alcalá de Henares, Madrid, España.
Fernández de Paz
F J
FJ
Barrio
V
V
Cuadrado-Gomez
L M
LM
Albarran-Hernandez
F
F
Alvarez de Mon
M
M
D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002779:Cholestasis / Q000209:etiology; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000097:blood / Q000503:physiopathology* / Q000601:surgery / Q000652:urine; D006029:Glycosuria; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood* / Q000150:complications / Q000652:urine; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000150:complications / Q000652:urine; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014527:Uric Acid / Q000097:blood* / Q000652:urine
D001786:Blood Glucose; D014527:Uric Acid; D001663:Bilirubin