Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion.
Endothelial cells co-express platelet-activating factor and P-selectin on their surfaces after activation by certain receptor-mediated agonists. Together they mediate the adhesion of leukocytes to the endothelial cell surface. P-selectin tethers leukocytes to the endothelial cell surface allowing leukocyte activation by platelet-activating factor. Adhesion and activation are specific for leukocytes because they are the only cells known to express the ligand for P-selectin. Leukocytes adherent to the endothelial cell surface may promote thrombosis by three mechanisms: (1) they secrete factors that damage the underlying endothelium, (2) they secrete factors that directly initiate the coagulation cascade, and (3) they bind and activate platelets.
Lorant
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DE
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City, USA.
Zimmerman
G A
GA
McIntyre
T M
TM
Prescott
S M
SM
D000818:Animals; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D019007:P-Selectin / Q000378:metabolism; D010972:Platelet Activating Factor / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D013927:Thrombosis / Q000503:physiopathology
D019007:P-Selectin; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor