title: Perspectives of pQCT technology associated to biomechanical studies in skeletal research employing rat models.
abstract: Assessment of bone material quality and architectural indicators by means of peripheral quantitative computed tomography (pQCT) offers a wide perspective for skeletal research employing noninvasive procedures. Some mechanically-validated examples of these pQCT applications in animal models are described. They concern (a) the analysis of bone mechanostatical interrelationships as shown by experimental "distribution/quality" curves, and (b) the noninvasive determination of bone strength. An attractive attempt to extrapolate the latter to human bone studies is also discussed.
authors.affiliation: CEMFoC-CIUNR-CONICET, National University of Rosario, Argentina.
authors.forename: J L
authors.initials: JL
authors.lastname: Ferretti
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D006801:Humans; D051381:Rats; D015203:Reproducibility of Results; D012107:Research Design; D014057:Tomography, X-Ray Computed