Familial multiple cutaneous leiomyomas.
BACKGROUND
Leiomyomas are rare, benign tumors that originate from the arrector muscle of hair follicles (cutaneous leiomyoma, piloleiomyoma), the tunica dartos of the scrotum and the mammillary muscle of the nipple (genital leiomyoma), and the smooth muscle of blood vessels (angioleiomyoma).


METHODS
We describe 6 members of a single family with mostly painful papulonodular cutaneous lesions on the limbs, trunk and face. Histological examination of sections stained with hematoxylin-eosin and Masson trichromic stain confirmed the diagnosis of leiomyoma. All affected women had also uterine myoma.


CONCLUSIONS
Our observations support the concept that this entity is an autosomally inherited disorder.
Fernández-Pugnaire
M A
MA
Department of Medicine, School of Medicine, University of Granada, Spain.
Delgado-Florencio
V
V
D000328:Adult; D000368:Aged; D005121:Extremities; D005153:Facial Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D018859:Hair Follicle / Q000473:pathology; D006801:Humans; D018231:Leiomyomatosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D013899:Thoracic Neoplasms / Q000235:genetics / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology