Early events in infection of lymphoid tissue by a lentivirus, maedi-visna.
All members of the lentivirus family infect cells of the monocyte-macrophage lineage, although this may be obscured during infection in vivo by the effect of the virus on other cells, such as CD4+ lymphocytes. Macrophages are the major cell type infected by the ruminant lentivirus maedi-visna, making it a valuable model for studying the pathogenesis of lentiviruses in these cells.
Blacklaws
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B
Dept of Clinical Veterinary Medicine, University of Cambridge, UK. bab2@cam.ac.uk
Bird
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P
McConnell
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I
D000818:Animals; D006801:Humans; D016086:Lentivirus / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology / Q000821:virology*; D017735:Virus Latency; D016182:Visna / Q000276:immunology / Q000821:virology*; D014790:Visna-maedi virus / Q000276:immunology*