title: Natural interferon-beta and tamoxifen in hormone-resistant patients with advanced breast cancer.
abstract: Tamoxifen (T) is the mainstay of hormonal treatment and is able to give high response rates in selected postmenopausal women with advanced breast cancer (ABC). Nevertheless, even in responders, invariably resistance to hormones is developed. In a previous paper we reported that in a subset of patients (pts) with metastatic breast cancer the resistance to the antiestrogen could be overcome by pretreatment with natural interferon-beta (nIFN-beta) followed by the association of nIFN-beta and T. In the present study we adopted a treatment schedule employing nIFN-beta (3 x 10(6) IU/day im three times a week) and T (60 mg/day) concurrently in 30 pts with ABC progressive to previous treatment with T (30 mg/day). We obtained a 13% response rate with a median duration of response of 8 months (range 4-16 m). All the responses occurred in pts whose disease progressed after an initial response to T. Stabilisation of disease was observed in 37%. Toxicity was mild. In our opinion the use of the combination T plus nIFN-beta in the treatment of breast cancer remains investigational and the optimal scheduling still undetermined.
authors.affiliation: Medical Oncology Service, of Tern, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Buzzi
authors.forename: M
authors.initials: M
authors.lastname: Brugia
authors.forename: F
authors.initials: F
authors.lastname: Trippa
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Trivisonne
authors.forename: L
authors.initials: L
authors.lastname: Giustini
authors.forename: D
authors.initials: D
authors.lastname: Pinaglia
authors.forename: V
authors.initials: V
authors.lastname: Capparella
authors.forename: G
authors.initials: G
authors.lastname: Sica
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage*; D008875:Middle Aged; D013629:Tamoxifen / Q000008:administration & dosage*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D016899:Interferon-beta