title: Reduced stomach capacity in obese subjects after dieting.
abstract: The objective of the study was to assess the change in gastric capacity of obese subjects consuming a hypoenergetic diet. Otherwise healthy, obese subjects participated in a prospective controlled study as hospital outpatients. Fourteen (11 females, 3 males) subjects were assigned to the diet group and 9 (7 females, 2 males) were assigned to the control group. Subjects in the diet group were provided a 2508-kJ/d(600 kcal/d) formula diet for 4 wk. Subjects in the control group ate ad libitum for 4 wk. Gastric capacity was determined before the study and 4 wk later by oral insertion of a latex gastric balloon after an overnight fast. The balloon was infused with water at a rate of 100 mL/min, with pauses for measuring intragastric pressure, until no further distension was tolerated. Two indexes for estimating gastric capacity were used based on subjective and objective criteria: 1) the maximal volume that could be tolerated, and 2) the volume required to produce a rise in water pressure of 5 cm. Subjects in the diet group, who lost a mean of 9.1 kg, showed a 27% reduction in gastric capacity based on the first index (P = 0.004) and a 36% reduction based on the second index (P = 0.006). For the control subjects, gastric capacity did not change significantly with use of either index. The results demonstrate a reduction in gastric capacity in obese subjects after a restricted diet.
authors.affiliation: Department of Medicine and Psychiatry, St. Lukes-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.
authors.forename: A
authors.initials: A
authors.lastname: Geliebter
authors.forename: S
authors.initials: S
authors.lastname: Schachter
authors.forename: C
authors.initials: C
authors.lastname: Lohmann-Walter
authors.forename: H
authors.initials: H
authors.lastname: Feldman
authors.forename: S A
authors.initials: SA
authors.lastname: Hashim
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002404:Catheterization; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D015905:Gastric Balloon; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000503:physiopathology*; D011446:Prospective Studies; D013270:Stomach / Q000503:physiopathology*; D015431:Weight Loss