title: Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.
abstract: An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
authors.affiliation: Genelabs Technologies, Redwood City, CA 94063, USA.
authors.forename: J
authors.initials: J
authors.lastname: Linnen
authors.forename: J
authors.initials: J
authors.lastname: Wages
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhang-Keck
authors.forename: K E
authors.initials: KE
authors.lastname: Fry
authors.forename: K Z
authors.initials: KZ
authors.lastname: Krawczynski
authors.forename: H
authors.initials: H
authors.lastname: Alter
authors.forename: E
authors.initials: E
authors.lastname: Koonin
authors.forename: M
authors.initials: M
authors.lastname: Gallagher
authors.forename: M
authors.initials: M
authors.lastname: Alter
authors.forename: S
authors.initials: S
authors.lastname: Hadziyannis
authors.forename: P
authors.initials: P
authors.lastname: Karayiannis
authors.forename: K
authors.initials: K
authors.lastname: Fung
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatsuji
authors.forename: J W
authors.initials: JW
authors.lastname: Shih
authors.forename: L
authors.initials: L
authors.lastname: Young
authors.forename: M
authors.initials: M
authors.lastname: Piatak
authors.forename: C
authors.initials: C
authors.lastname: Hoover
authors.forename: J
authors.initials: J
authors.lastname: Fernandez
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: J C
authors.initials: JC
authors.lastname: Zou
authors.forename: T
authors.initials: T
authors.lastname: Morris
authors.forename: K C
authors.initials: KC
authors.lastname: Hyams
authors.forename: S
authors.initials: S
authors.lastname: Ismay
authors.forename: J D
authors.initials: JD
authors.lastname: Lifson
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: S K
authors.initials: SK
authors.lastname: Foung
authors.forename: H
authors.initials: H
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Bradley
authors.forename: H
authors.initials: H
authors.lastname: Margolis
authors.forename: J P
authors.initials: JP
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000595:Amino Acid Sequence; D001483:Base Sequence; D001782:Blood Donors; D017848:Blood-Borne Pathogens; D002908:Chronic Disease; D003001:Cloning, Molecular; D016384:Consensus Sequence; D018562:Disease Transmission, Infectious; D018067:Flaviviridae / Q000235:genetics; D016679:Genome, Viral; D006518:Hepatitis Viruses / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012328:RNA Viruses / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D016415:Sequence Alignment; D065227:Transfusion Reaction; D014481:United States / Q000453:epidemiology; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics; D014766:Viremia / Q000453:epidemiology / Q000821:virology
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins