title: Practical management of treatment-resistant affective disorders.
abstract: The Geoffrey Knight National Unit was set up in 1970 exclusively for psychosurgery. In recent years it has become increasingly concerned with the development of medication regimens that might avoid the need for surgery. This has offered a unique pharmacotherapeutic opportunity because all the referrals have severe, persistent and treatment-resistant disorders. The scheme of high-dose and combined medication devised is presented and discussed.
authors.affiliation: Geoffrey Knight National Unit for Affective Disorders, Maudsley Hospital, London.
authors.forename: P K
authors.initials: PK
authors.lastname: Bridges
authors.forename: A D
authors.initials: AD
authors.lastname: Hodgkiss
authors.forename: A L
authors.initials: AL
authors.lastname: Malizia
mesh_terms: D000465:Algorithms; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003663:Decision Trees; D004359:Drug Therapy, Combination; D004565:Electroconvulsive Therapy; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D018579:Patient Selection; D011612:Psychosurgery / Q000379:methods*; D012017:Referral and Consultation; D017211:Treatment Failure
chemical_list: D000928:Antidepressive Agents