Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater.
The presence of the neurotrophin, nerve growth factor, brain derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 (NGF, BDNF, NT-3 and NT-4) and their receptors of the tyrosine kinase family (trkA, trkB and trkC) have been investigated in the choroid plexus and dura mater of the adult rat by ribonuclease protection assay. The choroid plexus contained high levels of mRNAs for NGF and NT-4, and low levels of NT-3 and BDNF mRNA; and high levels of trkB mRNA, and undetectable levels of trkA and trkC mRNA. In the dura mater there were high levels of NT-3 and NGF, and low levels of BDNF and NT-4 mRNAs; and high levels of trkC mRNA, and relatively high amount of trkB mRNA, while levels of trkA mRNA was undetectable. The present analysis revealed a different distribution of neurotrophins and their related receptors in the choroid plexus and dura mater.
Timmusk
T
T
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Mudò
G
G
Metsis
M
M
Belluardo
N
N
D000818:Animals; D002831:Choroid Plexus / Q000378:metabolism*; D004388:Dura Mater / Q000378:metabolism*; D015870:Gene Expression / Q000235:genetics; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*
D009414:Nerve Growth Factors; D012333:RNA, Messenger; D017475:Receptors, Nerve Growth Factor; D011505:Protein-Tyrosine Kinases