title: Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion.
abstract: Endothelial cells co-express platelet-activating factor and P-selectin on their surfaces after activation by certain receptor-mediated agonists. Together they mediate the adhesion of leukocytes to the endothelial cell surface. P-selectin tethers leukocytes to the endothelial cell surface allowing leukocyte activation by platelet-activating factor. Adhesion and activation are specific for leukocytes because they are the only cells known to express the ligand for P-selectin. Leukocytes adherent to the endothelial cell surface may promote thrombosis by three mechanisms: (1) they secrete factors that damage the underlying endothelium, (2) they secrete factors that directly initiate the coagulation cascade, and (3) they bind and activate platelets.
authors.affiliation: Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Lorant
authors.forename: G A
authors.initials: GA
authors.lastname: Zimmerman
authors.forename: T M
authors.initials: TM
authors.lastname: McIntyre
authors.forename: S M
authors.initials: SM
authors.lastname: Prescott
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D019007:P-Selectin / Q000378:metabolism; D010972:Platelet Activating Factor / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D013927:Thrombosis / Q000503:physiopathology
chemical_list: D019007:P-Selectin; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor