Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone.
OBJECTIVE
To evaluate the ability of an ultrasound (US)-measured periovulatory endometrial thickness to predict conception in hMG-stimulated cycles.


METHODS
Retrospective.


METHODS
A university-based tertiary practice.


METHODS
One hundred twelve patients undergoing 292 cycles of ovulation induction with hMG alone.


METHODS
A periovulatory transvaginal US measurement of endometrial thickness was obtained during cycles of ovulation induction with hMG alone. Clinical pregnancy was defined by fetal cardiac activity. Sensitivity and false-positive rates for multiple discriminatory values of endometrial thickness were calculated and a relative operating characteristic (ROC) curve was constructed to evaluate the performance of this test as a predictor of pregnancy.


RESULTS
Thirty-eight of 292 cycles resulted in pregnancy. Conception and nonconception cycles showed similar demographics, diagnoses, peak E2, maximum number of follicles, midluteal P, and mean endometrial thickness. Ovulatory dysfunction was a more frequent diagnosis in the conception group. Relative operating characteristic analysis for endometrial thickness as a predictor of pregnancy yielded an area under the curve of 0.623 +/- 0.049 (mean +/- SD).


CONCLUSIONS
Endometrial thickness is a valid screening test for conception outcome in cycles stimulated with hMG. A periovulatory endometrial thickness > or = 10 mm defined 91% of conception cycles. No pregnancy occurred when the endometrium measured < 7 mm.
Isaacs
J D
JD
Washington University School of Medicine, Department of Obstetrics and Gynecology, St. Louis, Missouri, USA.
Wells
C S
CS
Williams
D B
DB
Odem
R R
RR
Gast
M J
MJ
Strickler
R C
RC
D000328:Adult; D004717:Endometrium / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D008991:Monitoring, Physiologic; D010062:Ovulation Induction / Q000379:methods*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
D005300:Fertility Agents, Female; D008596:Menotropins