title: Serohematologic alterations in broiler chicks on feed amended with Fusarium proliferatum culture material on fumonisin B1 and moniliformin.
abstract: Two hundred twenty-eight male broiler chicks (Columbia x New Hampshire) were given feed amended with autoclaved culture material of Fusarium proliferatum containing fumonisin B1 (FB1) at 61, 193, and 546 ppm, fumonisin B2 (FB2) at 14, 38, and 98 ppm, and moniliformin at 66, 193, and 367 ppm in 3 separate feeding trials (amounts of toxin in each trial, respectively). Birds were started on amended rations at days 1, 7, and 21 and continuing for 14 days. Of serum chemistry parameters, only glucose was significantly decreased. Significant increases were noted in serum cholesterol, sodium, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and gamma-glutamyl transferase. Of the hematologic parameters, significant decreases were noted in red blood cell counts, hemoglobin, packed cell volume, and white blood cell counts. Immunologic changes included impaired anti-Newcastle disease antibody hemagglutination inhibition titers associated with relative decreases in total serum globulins and increases in albumin/globulin ratios. The changes were noted in all treatment groups when compared to controls.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
authors.forename: T
authors.initials: T
authors.lastname: Javed
authors.forename: M A
authors.initials: MA
authors.lastname: Dombrink-Kurtzman
authors.forename: J L
authors.initials: JL
authors.lastname: Richard
authors.forename: G A
authors.initials: GA
authors.lastname: Bennett
authors.forename: L M
authors.initials: LM
authors.lastname: Côté
authors.forename: W B
authors.initials: WB
authors.lastname: Buck
mesh_terms: D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002645:Chickens / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003503:Cyclobutanes / Q000008:administration & dosage / Q000494:pharmacology*; D004798:Enzymes / Q000097:blood; D004906:Erythrocyte Count / Q000187:drug effects; D005527:Food, Fortified; D037341:Fumonisins; D005670:Fusarium; D006385:Hemagglutination Inhibition Tests; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009183:Mycotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D012964:Sodium / Q000097:blood; D013723:Teratogens / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D003503:Cyclobutanes; D004798:Enzymes; D037341:Fumonisins; D006454:Hemoglobins; D009183:Mycotoxins; D013723:Teratogens; C008539:moniliformin; C056933:fumonisin B1; D002784:Cholesterol; D012964:Sodium; D003404:Creatinine