Parsimonious estimation of sex-specific map distances by stepwise maximum likelihood regression.
In human genetic maps, differences between female (xf) and male (xm) map distances may be characterized by the ratio, R = xf/xm, or the relative difference, Q = (xf - xm)/(xf + xm) = (R - 1)/(R + 1). For a map of genetic markers spread along a chromosome, Q(d) may be viewed as a graph of Q versus the midpoints, d, of the map intervals. To estimate male and female map distances for each interval, a novel method is proposed to evaluate the most parsimonious trend of Q(d) along the chromosome, where Q(d) is expressed as a polynomial in d. Stepwise maximum likelihood polynomial regression of Q is described. The procedure has been implemented in a FORTRAN program package, TREND, and is applied to data on chromosome 18.
Fann
C S
CS
Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, USA.
Ott
J
J
D002877:Chromosomes, Human; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005819:Genetic Markers; D005826:Genetics, Medical; D006801:Humans; D008297:Male; D008957:Models, Genetic; D008962:Models, Theoretical; D011336:Probability; D012044:Regression Analysis; D012727:Sex Characteristics
D005819:Genetic Markers