A randomized trial of amphotericin B alone or in combination with itraconazole in the treatment of mucocutaneous leishmaniasis.
A randomized trial of amphotericin B (AB) alone and in combination with oral itraconazole (IZ) is carried out in two groups of 10 mucocutaneous leishmaniasis patients from Bolivia and Peru. AB+IZ combination is no better than AB monotherapy, as far as efficacy and tolerability are concerned. No antagonism was detected.
Rodriguez
L V
LV
Servicio de Dermatologia, Hospital de Clinicas Universitario, Miraflores, La Paz, Bolivia.
Dedet
J P
JP
Paredes
V
V
Mendoza
C
C
Cardenas
F
F
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000900:Anti-Bacterial Agents; D017964:Itraconazole; D000666:Amphotericin B