[The effect of subinhibitory concentrations of quinolone and macrolide antibiotics on production of thermolabile hemolysins in Pseudomonas aeruginosa].
The authors investigated the effect of subinhibitory concentrations (sub-MICs) of selected quinolones (enoxacine, nalidixic acid, norfloxacine) and macrolid antibiotics (erythromycin, roxitromycin) on the production of thermolabile haemolysin (phospholipase C) of P. aeruginosa. The activity of phospholipase C was markedly reduced by norfloxacine (more than 80%) and enoxacine (75 - 80%) in all sub-MICs. Nalidixic acid inhibited phospholipase C in 1/4 of MIC (75%). As to macrolid antibiotics the greatest inhibition was caused by erthromycin in 1/4 and 1/8 MIC (more than 90%). 1/16 MIC of roxitromycin did not influence the activity of the investigated enzyme and other tested sub-MICs caused its reduction to cca one half.
Hybenová
D
D
Ustav preventívnej a klinickej medicíny, Bratislava.
Majtán
V
V
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D018942:Macrolides; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000378:metabolism*; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006460:Hemolysin Proteins; D018942:Macrolides; D010738:Type C Phospholipases
Ucinok subinhibicných koncentrácií chinolónov a makrolidových antibiotík na produkciu termolabilného hemolyzínu Pseudomonas aeruginosa.