title: School-age follow-up of a single-dose prophylactic surfactant cohort.
abstract: This study reports the school-age developmental and health status of a preventilatory surfactant cohort. The sample consisted of 39 surviving subjects (21 experimental and 18 controls) born at 25 to 29 weeks gestation who were studied at 6 and 12 months and 5 to 7 years of age. At 6- and 12-month follow-ups, the cohort was functioning close to the population normative mean. Although cognitive and motor assessments at school age also showed no group differences, 8 of 19 (42%) in the surfactant group and 9 of 17 (53%) in the normal saline group attained a McCarthy General Cognitive Index score of < or = 84 (abnormal range). On the Connors' Parental Questionnaire, both groups scored high on the Learning Disability Subscale. The surviving cohort at 5 to 7 years had no identified long-term sequelae due to surfactant therapy, yet both groups were at risk for neurodevelopmental and educational morbidity.
authors.affiliation: Department of Pediatrics, University of Rochester Medical Center, New York, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Wagner
authors.forename: B M
authors.initials: BM
authors.lastname: Kramer
authors.forename: J W
authors.initials: JW
authors.lastname: Kendig
authors.forename: J G
authors.initials: JG
authors.lastname: Brooks
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: M T
authors.initials: MT
authors.lastname: Wagner
authors.forename: D L
authors.initials: DL
authors.lastname: Phelps
mesh_terms: D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006305:Health Status Indicators; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*
chemical_list: D011663:Pulmonary Surfactants