Antigen-independent reactivation of anti-E, years after allogeneic bone marrow transplantation: a case report.
Nine years after allogenic bone marrow transplantation a strong anti-E was observed in a patient transplanted with bone marrow from his HLA-identical brother. This IgG anti-E, with a titre of 4000, was detected together with autoantibodies to red blood cells and platelets and was not induced by transfusion with E+ cells. The hypothesis is proposed that the anti-E represents either antigen-independent desuppression of the donor immune system sensitized at the time of bone marrow transplantation by E antigens in the recipient, or antigen-independent memory B-cell activation by Epstein-Barr virus infection.
Wernet
D
D
Department of Transfusion Medicine, University Hospital, Tübingen, Germany.
Weiss
B
B
Schmidt
H
H
Northoff
H
H
D001323:Autoantibodies / Q000276:immunology; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D012203:Rh Isoimmunization; D014184:Transplantation, Homologous
D001323:Autoantibodies; D007074:Immunoglobulin G