title: Once-daily tobramycin therapy in lower respiratory tract infections.
abstract: In a multicenter Italian study of 104 adult patients with severe bacterial lower respiratory tract infections, the safety and efficacy of a regimen of high dose, once-daily tobramycin alone or in combination with antipseudomonas betalactams was assessed. The overall bacteriological response was an elimination of the original pathogen in 70% of the patients while the overall clinical response mirrored the bacteriological results with a successful clinical outcome in 78% of patients. Adverse experiences were, in general, few and mild without oto- or nephrotoxicity. The once-daily, high dose regimen of tobramycin proved to be a safe and efficacious therapy for severe lower respiratory tract infections in adult patients.
authors.affiliation: Clinica Tisiologica e Malattie dell'Apparato Respiratorio, Università, Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Grassi
authors.forename: F
authors.initials: F
authors.lastname: Ginesu
authors.forename: E
authors.initials: E
authors.lastname: Pozzi
authors.forename: R
authors.initials: R
authors.lastname: Rimoldi
authors.forename: N
authors.initials: N
authors.lastname: Crimi
authors.forename: P
authors.initials: P
authors.lastname: Periti
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007558:Italy; D007769:Lactams; D008171:Lung Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014031:Tobramycin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D014031:Tobramycin