title: A dialysis patient with systemic calciphylaxis exhibiting rapidly progressive visceral ischemia and acral gangrene.
abstract: Systemic calciphylaxis is a rare, poorly understood syndrome of progressive peripheral ischemic necrosis and medial arterial calcification in patients with end-stage renal disease. We report a patient with this syndrome which developed following corticosteroid administration and who ultimately required amputation of the four extremities. Furthermore, cerebral, myocardial, splenic, and intestinal infarctions also developed in parallel with the increment of visceral arterial calcification. No evidence of noticeable hyperparathyroidism or elevation of serum calcium-phosphate product was observed. We speculated that, in addition to diabetes mellitus and chronic renal failure while undergoing dialysis therapy, the administration of corticosteroids might act synergistically to cause calciphylaxis.
authors.affiliation: Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu.
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Hiroshige
authors.forename: A
authors.initials: A
authors.lastname: Osajima
authors.forename: M
authors.initials: M
authors.lastname: Soejima
authors.forename: M
authors.initials: M
authors.lastname: Takasugi
authors.forename: A
authors.initials: A
authors.lastname: Kuroiwa
mesh_terms: D002115:Calciphylaxis / Q000150:complications*; D048909:Diabetes Complications; D005121:Extremities / Q000098:blood supply*; D017809:Fatal Outcome; D005260:Female; D005734:Gangrene / Q000209:etiology*; D006801:Humans; D007511:Ischemia / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D014781:Viscera / Q000098:blood supply*