Function and metabolism of brain synaptosomes in chronic renal failure.
Patients with advanced renal failure have derangements in the function of their nervous system. The available clinical and experimental data indicate that the state of the secondary hyperparathyroidism of renal failure plays a major role in the genesis of the nervous system dysfunction. The excess parathyroid hormone (PTH) mediates its deleterious effect by causing an elevation in cytosolic calcium of brain cells. This report reviews the evidence leading to the conclusion that PTH is a major uremic toxin.
Smogorzewski
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M
Division of Nephrology, University of Southern California, School of Medicine, Los Angeles 90033, USA.
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Massry
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D000109:Acetylcholine / Q000378:metabolism; D015152:Blotting, Northern; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology; D009498:Neurotoxins / Q000009:adverse effects; D010281:Parathyroid Hormone / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism* / Q000502:physiology
D009498:Neurotoxins; D010281:Parathyroid Hormone; D012333:RNA, Messenger; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D000109:Acetylcholine; D002118:Calcium