[Complications of allogeneic microsurgical transplantation of a limb (composite tissue), in rats].
OBJECTIVE
To analyze the composite tissue vascularized allotransplantation post operative complications and to identify factors associated with agents toxicity.


METHODS
The study was done across a strong histocompatibility barrier using 39 Brown-Norway rats as donors and 78 Fischer 344 as hindlimb allotransplantation recipients treated with cyclosporine and RS-61443.


RESULTS
1 (1/78: 1.28%) was eliminated owing to thrombosis; 2 (2/78: 2.56%) owing to enteritis; 1 (1/78: 1.28%) owing to autophagia and 8 (8/78: 10.42%) died owing to undiscovered cause.


CONCLUSIONS
Among 78 (78/78: 100%) rat limb vascularized allotransplantations, 12 (15.5%) rats died or were eliminated because of acute postoperative complications that were not related to rejection, to immunosuppressive toxicity or to opportunistic infection.
Ferreira
L M
LM
Departamento de Cirurgia, Universidade Federal de São Paulo-Escola Paulista de Medicina.
Anthony
J P
JP
Mathes
S
S
Andrews
J M
JM
Laredo Filho
J
J
D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage*; D006614:Hindlimb / Q000637:transplantation*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008866:Microsurgery; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011183:Postoperative Complications / Q000209:etiology*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000401:mortality
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid
Complicações em transplante alógeno microcirúrgico de membro (tecido composto), em ratos.