Protein kinases and phosphatases that act on histidine, lysine, or arginine residues in eukaryotic proteins: a possible regulator of the mitogen-activated protein kinase cascade.
Phosphohistidine goes undetected in conventional studies of protein phosphorylation, although it may account for 6% of total protein phosphorylation in eukaryotes. Procedures for studying protein N- kinases are described. Genes whose products are putative protein histidine kinases occur in a yeast and a plant. In rat liver plasma membranes, activation of the small G-protein, Ras, causes protein histidine phosphorylation. Cellular phosphatases dephosphorylate phosphohistidine. One eukaryotic protein histidine kinase has been purified, and specific proteins phosphorylated on histidine have been observed. There is a protein arginine kinase in mouse and protein lysine kinases in rat. Protein phosphohistidine may regulate the mitogen-activated protein kinase cascade.
Matthews
H R
HR
Department of Biological Chemistry, University of California at Davis 95616, USA.
D000818:Animals; D001120:Arginine / Q000187:drug effects* / Q000378:metabolism; D015195:Drug Design; D006639:Histidine / Q000187:drug effects* / Q000378:metabolism; D008239:Lysine / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases; D010749:Phosphoprotein Phosphatases / Q000378:metabolism / Q000494:pharmacology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000187:drug effects* / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D015003:Yeasts / Q000201:enzymology
D006639:Histidine; D001120:Arginine; D011494:Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; D010749:Phosphoprotein Phosphatases; D008239:Lysine