title: Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease.
abstract: This report describes the prospective and systematic psychiatric assessment of nine patients who received transplantation of human fetal mesencephalic tissue into the caudate nucleus for treatment of Parkinson's disease. Unlike adrenal medullary transplantation, which often causes psychosis or delirium, this procedure appeared to have few perioperative sequelae. On longer-term follow-up, there was some statistical evidence of deterioration in psychiatric status, as manifested primarily in depressive and nonspecific emotional and behavioral symptoms. This group effect was partly attributable to the occurrence of discrete episodes of illness (major depression and panic disorder with agoraphobia) in some patients, but it was unclear whether such episodes occurred more often than would ordinarily be expected in Parkinson's disease. Differences in the neurobiological effects of fetal mesencephalic and adrenal medullary grafts may account for differences in the psychiatric sequelae of patients receiving these procedures.
authors.affiliation: Yale Neural Transplant Program, Yale University School of Medicine, New Haven, CT 06519, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Price
authors.forename: D D
authors.initials: DD
authors.lastname: Spencer
authors.forename: K L
authors.initials: KL
authors.lastname: Marek
authors.forename: R J
authors.initials: RJ
authors.lastname: Robbins
authors.forename: C
authors.initials: C
authors.lastname: Leranth
authors.forename: A
authors.initials: A
authors.lastname: Farhi
authors.forename: F
authors.initials: F
authors.lastname: Naftolin
authors.forename: R H
authors.initials: RH
authors.lastname: Roth
authors.forename: B S
authors.initials: BS
authors.lastname: Bunney
authors.forename: P B
authors.initials: PB
authors.lastname: Hoffer
mesh_terms: D000328:Adult; D000368:Aged; D016380:Brain Tissue Transplantation / Q000502:physiology / Q000523:psychology*; D002421:Caudate Nucleus / Q000503:physiopathology / Q000601:surgery; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology; D004298:Dopamine / Q000502:physiology; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology / Q000523:psychology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000637:transplantation*; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000503:physiopathology / Q000523:psychology*; D009483:Neuropsychological Tests; D016584:Panic Disorder / Q000503:physiopathology / Q000523:psychology; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology / Q000523:psychology*; D011446:Prospective Studies
chemical_list: D004298:Dopamine