The effects of H2 and non-H2 genes on the survival of Onchocerca lienalis microfilariae in the mouse.
The effect of H2 and non-H2 genes in a mouse model of protective immunity against Onchocerca lienalis microfilariae have been investigated. Non-H2 effects were determined using CBA, BALB/c, B10, SJL and TO strains. All were permissive for establishment of a primary infection with microfilariae, although significant differences in parasite recoveries were evident amongst the various strains. The effect of H2 genes upon a primary infection was investigated using H2 congenic B10 and BALB strains, B10, B10.S, B10.BR, B10.D2/n, BALB/c, BALB.B, and BALB.K. Significant H2 effects were seen among the relatively weak responder B10 strains, but were not present among the relatively strong responder BALB strains. These results support a dominant effect of non-H2 genes following primary exposure to microfilariae, and a 'fine tuning' effect of H2 genes that is apparent only in weaker responding strains. Upon reinfection of all the strains investigated, a gradation of protection was detected that appeared to be exclusively dependent upon H2.
Folkard
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SG
Liverpool School of Tropical Medicine, UK.
Bianco
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AE
D000818:Animals; D004198:Disease Susceptibility; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006239:Haplotypes; D007110:Immunity, Active; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008842:Microfilariae / Q000302:isolation & purification / Q000502:physiology; D009854:Onchocerca / Q000302:isolation & purification / Q000502:physiology*; D009855:Onchocerciasis / Q000235:genetics / Q000276:immunology*