Compatibility of ondansetron hydrochloride with meperidine hydrochloride for combined administration.
OBJECTIVE
To determine the physical compatibility and chemical stability of ondansetron hydrochloride 0.1 and 1 mg/mL with meperidine hydrochloride 4 mg/mL admixed in NaCl 0.9% injection USP.


METHODS
Triplicate test solutions of the drugs in NaCl 0.9% injection USP were prepared and stored at 4, 22, and 32 degrees C. Samples were removed initially and at various time points over 31 days and were stored at -70 degrees C until they were analyzed. Physical compatibility was assessed by measuring solution turbidity with a color-correcting turbidimeter and particle content with a light-obscuration particle sizer/counter, as well as by visual assessment. Chemical stability of the drugs was determined using a stability-indicating HPLC analytic method. Duplicate determinations were performed on each sample to measure the concentration of each drug.


RESULTS
All admixtures were found to exhibit no visual or subvisual changes of consequence in turbidity or particle content at all observation points. Further, little or no loss of any of the drugs occurred in any concentration throughout the study.


CONCLUSIONS
The physical compatibility and chemical stability of ondansetron hydrochloride with meperidine hydrochloride under the conditions of this study have been established for 7 days at 32 degrees C and 31 days at 4 and 22 degrees C.
Xu
Q A
QA
Division of Pharmacy, University of Texas, MD Anderson Cancer Center, Houston 77030, USA.
Trissel
L A
LA
Fox
J L
JL
D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004344:Drug Incompatibility; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D008614:Meperidine / Q000737:chemistry*; D017294:Ondansetron / Q000737:chemistry*; D013696:Temperature
D004338:Drug Combinations; D017294:Ondansetron; D008614:Meperidine