[Acridine mutagen ICR-170 induced developmental suppression of ovary and vitelline gland in female Schistosoma japonicum].
Mice of Kunming strain were infected with Schistosoma japonicum cercariae previously incubated with various concentrations of acridine mutagen ICR-170 for different time durations. At 6 weeks after infection, the mice were autopsied. The results showed that 24 out of 28(85.7%) adult female worms had deformed or lacked ovaries and vitelline glands when the cercariae were treated with the agent at a concentration of 10 micrograms/ml and incubated at 30.5 degrees C for 30min. No apparent changes were observed in the male worms inhabiting the mesenteric and portal veins with the females worms in their gynecophoral canals. The mutagenized female schistosomes obtained from the present experiment might be served as another form of attenuated worms for the induction of protective immunity.
Lu
Q
Q
Shanghai Municipal Institute of Parasitic Diseases.
Jiang
S
S
Zhang
B
B
Pan
C
C
Zhu
G
G
Fu
F
F
D000609:Aminoacridines / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*; D012549:Schistosoma japonicum / Q000187:drug effects*
D000609:Aminoacridines; D009153:Mutagens; D009588:Nitrogen Mustard Compounds; C091910:acridine mustard