From pseudocholinesterase to human immunodeficiency virus.
Pseudocholinesterase is a protein for which no function exists in mammals including human beings. To date, no substrate has been identified for this 'enzyme'. Involvement of this protein in the aetiopathogenesis of many diseases, such as hyperlipoproteinaemia, is still actively debated. Here, we propose a theoretical method to immobilize pseudocholinesterase in hepatocytes using antibody bound to liposomes. Conceptually, this approach will have widespread application, especially in blocking human immunodeficiency virus replication in vivo.
Madhavankutty
K
K
Department of Pediatrics, Faculty of Medicine, Memorial University of Newfoundland, Canada.
Shyamasundar
K
K
Andrews
W
W
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D001057:Apolipoproteins E / Q000008:administration & dosage* / Q000378:metabolism; D001671:Biochemistry / Q000379:methods*; D002091:Butyrylcholinesterase / Q000276:immunology / Q000502:physiology*; D002738:Chloroquine / Q000494:pharmacology; D004337:Drug Carriers; D004705:Endocytosis; D004789:Enzyme Activation; D006678:HIV / Q000201:enzymology*; D015483:HIV Antibodies / Q000008:administration & dosage*; D015699:HIV Envelope Protein gp120 / Q000008:administration & dosage* / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy / Q000628:therapy / Q000821:virology; D054303:HIV Reverse Transcriptase; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage*; D007167:Immunotherapy / Q000379:methods*; D008081:Liposomes; D008099:Liver / Q000201:enzymology*; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008322:Mammals / Q000378:metabolism; D012194:RNA-Directed DNA Polymerase / Q000276:immunology; D018110:Receptors, Lipoprotein / Q000378:metabolism; D015215:Zidovudine / Q000008:administration & dosage
D000906:Antibodies; D001057:Apolipoproteins E; D004337:Drug Carriers; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D018796:Immunoconjugates; D008081:Liposomes; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D018110:Receptors, Lipoprotein; D015215:Zidovudine; D002738:Chloroquine; C072416:reverse transcriptase, Human immunodeficiency virus 2; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase; D002091:Butyrylcholinesterase