title: A randomised prospective comparison of percutaneous endoscopic gastrostomy and nasogastric tube feeding after acute dysphagic stroke.
abstract: OBJECTIVE
  To compare percutaneous endoscopic gastrostomy and nasogastric tube feeding after acute dysphagic stroke.
  
  
  METHODS
  Randomised prospective study of inpatients with acute stroke requiring enteral nutrition.
  
  
  METHODS
  One university hospital (Nottingham) and one district general hospital (Derby).
  
  
  METHODS
  30 patients with persisting dysphagia at 14 days after acute stroke: 16 patients were randomised to gastrostomy tube feeding and 14 to nasogastric tube feeding.
  
  
  METHODS
  Six week mortality; amount of feed administered; change in nutritional state; treatment failure; and length of hospital stay.
  
  
  RESULTS
  Mortality at 6 weeks was significantly lower in the gastrostomy group with two deaths (12%) compared with eight deaths (57%) in the nasogastric group (P < 0.05). All gastrostomy fed patients (16) received the total prescribed feed whereas 10/14 (71%) of nasogastric patients lost at least one day's feed. Nasogastric patients received a significantly (P < 0.001) smaller proportion of their prescribed feed (78%; 95% confidence interval 63% to 94%) compared with the gastrostomy group (100%). Patients fed via a gastrostomy tube showed greater improvement in nutritional state, according to several different criteria at six weeks compared with the nasogastric group. In the gastrostomy group the mean albumin concentration increased from 27.1 g/l (24.5 g/l to 29.7 g/l) to 30.1 g/l (28.3 g/l to 31.9 g/l). In contrast, among the nasogastric group there was a reduction from 31.4 g/l (28.6 g/l to 34.2 g/l) to 22.3 g/l (20.7 g/l to 23.9 g/l) (P < 0.003). In addition, there were fewer treatment failures in the gastrostomy group (0/16 versus 3/14). Six patients from the gastrostomy group were discharged from hospital within six weeks of the procedure compared with none from the nasogastric group (P < 0.05).
  
  
  CONCLUSIONS
  This study indicates that early gastrostomy tube feeding is greatly superior to nasogastric tube feeding and should be the nutritional treatment of choice for patients with acute dysphagic stroke.
authors.affiliation: Derbyshire Royal Infirmary, Derby.
authors.forename: B
authors.initials: B
authors.lastname: Norton
authors.forename: M
authors.initials: M
authors.lastname: Homer-Ward
authors.forename: M T
authors.initials: MT
authors.lastname: Donnelly
authors.forename: R G
authors.initials: RG
authors.lastname: Long
authors.forename: G K
authors.initials: GK
authors.lastname: Holmes
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D002561:Cerebrovascular Disorders / Q000150:complications / Q000401:mortality / Q000628:therapy*; D003680:Deglutition Disorders / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D005774:Gastrostomy / Q000379:methods*; D006801:Humans; D008297:Male; D009752:Nutritional Status; D011446:Prospective Studies