Early regionalized expression of a novel Xenopus fibroblast growth factor receptor in neuroepithelium.
A cDNA encoding a novel Xenopus fibroblast growth factor receptor, XFGFR4B, has been cloned. XFGFR4B mRNA is detected throughout embryogenesis. However, from the late gastrula stage on, XFGFR4B transcripts are expressed in two defined areas of the anterior neural plate. Interestingly, these two regions are fated to become parts of the retina, midbrain, hindbrain, and otic vesicle, all of which continue to express XFGFR4B mRNA in tailbud stage embryos and early tadpoles. Expression of XFGFR4B mRNA can be maintained at neurula stage in isolated blastula ectoderm in response to mesodermal induction by activin or neural induction by noggin, suggesting that XFGFR4B expression might be regulated by early cell interactions. Distribution of XFGFR4B mRNA suggests that XFGFR4B might serve an important function during patterning of neuroepithelium.
Riou
J F
JF
Laboratoire de Biologie Moléculaire et Cellulaire du Développement, URA CNRS 1135, Université Pierre et Marie Curie, Paris, France.
Clavilier
L
L
Boucaut
J C
JC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005775:Gastrula / Q000378:metabolism; D015870:Gene Expression; D017403:In Situ Hybridization; D008648:Mesoderm / Q000502:physiology; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis*; D011994:Recombinant Proteins / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014981:Xenopus / Q000196:embryology
D017931:DNA Primers; D018076:DNA, Complementary; D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D011994:Recombinant Proteins