Mu-opioid activation of phospholipase C in SH-SY5Y cells rapidly desensitizes: mechanistic studies.
Smart
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University Dept. of Anaesthesia, Leicester Royal Infirmary.
Lambert
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DG
D015761:4-Aminopyridine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D004789:Enzyme Activation / Q000187:drug effects; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate / Q000096:biosynthesis; D007546:Isoquinolines / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013449:Sulfonamides; D010738:Type C Phospholipases / Q000378:metabolism*
D007211:Indoles; D007546:Isoquinolines; D017450:Receptors, Opioid, mu; D013449:Sulfonamides; D015544:Inositol 1,4,5-Trisphosphate; D015761:4-Aminopyridine; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D010738:Type C Phospholipases; C063509:N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide; D002118:Calcium; D005283:Fentanyl; C064758:Ro 31-8220