title: [A case of biopsy-proven sarcoid meningoencephalitis presented with hallucination, nominal aphasia and dementia].
abstract: Here we report a 36-year-old male with sarcoid meningoencephalitis who initially presented with hallucination, nominal aphasia and disturbance of consciousness. After the onset, his symptoms fluctuated. He had no meningeal signs, and his cranial nerves were normal except for bilateral papapilledema. Muscle power and tone was normal, and there was no gait disturbance. Deep tendon reflexes were slightly exaggerated in lower extremities, but no pathological reflexes were noted. There was no impairment in extrapyramidal system, cerebellar system and sensory system. The cerebrospinal fluid revealed increased opening pressure, mild lymphocytic pleocytosis, slightly decreased glucose, increased protein to 87mg/dl and increased IgG index to 1.11. Cerebrospinal fluid culture was negative. Marked meningeal thickening and contrast enhancement was shown by CT and MRI. The meningeal biopsy demonstrated characteristic sarcoid nodules and confirmed the diagnosis of neurosarcoidosis. His manifestations were alleviated by oral administration of corticosteroid. Since neurosarcoidosis is a disorder treatable with corticosteroid, it is important to consider the possibility of this disorder in mind when a patient is presenting with psychiatric manifestations and chronic meningitis.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: J
authors.initials: J
authors.lastname: Onodera
authors.forename: T
authors.initials: T
authors.lastname: Nagata
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000328:Adult; D000849:Anomia / Q000209:etiology*; D003704:Dementia / Q000209:etiology*; D006212:Hallucinations / Q000209:etiology*; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000150:complications*; D012507:Sarcoidosis / Q000150:complications*