Animal models of protective immunity in tuberculosis to evaluate candidate vaccines.
While the etiology of tuberculosis is well understood, the nature of the protective immune response to the causative mycobacteria has remained a mystery. There is an urgent need to define protective immunity critically, and to develop alternative animal models to evaluate the efficacy of new-generation vaccines against tuberculosis in a cost-effective way.
Griffin
J F
JF
Dept of Microbiology, University of Otago, Dunedin, New Zealand. frank.griffin@stonebow.otago.ac.nz
Mackintosh
C G
CG
Buchan
G S
GS
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007109:Immunity; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
D001500:BCG Vaccine