Stachybocins, novel endothelin receptor antagonists, produced by Stachybotrys sp. M6222. II. Structure determination of stachybocins A, B and C.
The structures of stachybocins A, B and C, new endothelin receptor antagonist, were determined by NMR spectral analysis using pulse-field-gradient technique. Stachybocin A consists of two spirobenzofuran units each fused to a substituted decalin, which were connected by a lysine residue. Stachybocins B and C are derivatives of stachybocin A with an additional hydroxy group at the same position in the different decalin unit.
Ogawa
K
K
Institute for Life Science Research, Asahi Chemical Industry Co. Ltd, Shizuoka, Japan.
Nakamura
M
M
Hayashi
M
M
Yaginuma
S
S
Yamamoto
S
S
Furihata
K
K
Shin-Ya
K
K
Seta
H
H
D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology; D002247:Carbon Isotopes; D065128:Endothelin Receptor Antagonists; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology; D013191:Stachybotrys / Q000378:metabolism*; D014316:Tritium
D001572:Benzofurans; D002247:Carbon Isotopes; D065128:Endothelin Receptor Antagonists; D013141:Spiro Compounds; C097789:stachybocin A; C097790:stachybocin B; C097791:stachybocin C; D014316:Tritium