title: [Analgosedation with fentanyl/midazolam after correction of congenital heart defects].
abstract: There is no standard therapy in the management of postoperative pain control following corrective cardiac surgery of congenital heart disease. Assessment in the preverbal age is difficult. In a randomized study we compared a combined treatment of fentanyl and midazolam, given as continuous infusion versus single dose application. A pain assessment score was used to measure the effectiveness of analgosedation in addition to recording nurseries observations. Fentanyl and midazolam are an appropriate combination for postoperative pain treatment. Continuous application is considered to be more effective concerning basic anxiety, cumulative dosage and to avoid volume overload in infants and young children, following cardiac surgery; overdosage was not observed.
authors.affiliation: Kinderklinik der Johannes Gutenberg-Universität Mainz.
authors.forename: I
authors.initials: I
authors.lastname: Michel-Behnke
authors.forename: A
authors.initials: A
authors.lastname: Rothes
authors.forename: F
authors.initials: F
authors.lastname: Hund
authors.forename: R
authors.initials: R
authors.lastname: Huth
authors.forename: C F
authors.initials: CF
authors.lastname: Wippermann
authors.forename: F X
authors.initials: FX
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Oelert
authors.forename: D
authors.initials: D
authors.lastname: Schranz
mesh_terms: D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005283:Fentanyl; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D008874:Midazolam; D005283:Fentanyl
vernacular_title: Analgosedierung mit Fentanyl/Midazolam nach Korrektur angeborener Herzfehler.