title: Expression of M-twist during postimplantation development of the mouse.
abstract: The murine homologue of the Drosophila twist gene has been shown to be essential for head mesenchyme formation and to act as an inhibitor of muscle differentiation. This paper presents a detailed analysis of M-twist expression patterns from day 7 post coitum (p.c.) to day 18 p.c., indicating a more general function of the M-twist gene. At day 7 p.c., M-twist is expressed in the mesoderm outside the primitive streak. Later M-twist message is predominantly found in the somites, the head mesenchyme, the branchial arches, the limbs, and in the mesenchyme underneath the epidermis. Beginning at day 8 p.c., M-twist is mainly expressed in undifferentiated cells committed to muscle and cartilage development: this expression is consistent with a suggested role of M-twist in inhibiting overt muscle and cartilage differentiation. However, during organogenesis, M-twist is expressed in several areas of mesenchyme-epithelia interactions, suggesting additional tissue specific functions.
authors.affiliation: Max-Planck-Institut für Immunbiologie, Freiburg, Germany.
authors.forename: E M
authors.initials: EM
authors.lastname: Füchtbauer
mesh_terms: D000818:Animals; D002356:Cartilage / Q000196:embryology; D047108:Embryonic Development / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006351:Heart Valves / Q000196:embryology; D018257:Helix-Loop-Helix Motifs / Q000502:physiology; D017403:In Situ Hybridization; D018878:Limb Buds / Q000502:physiology; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D051379:Mice / Q000196:embryology*; D009132:Muscles / Q000196:embryology; D018006:Myogenic Regulatory Factors / Q000235:genetics; D009432:Neural Crest / Q000166:cytology / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D051879:Twist-Related Protein 1
chemical_list: D018006:Myogenic Regulatory Factors; D009687:Nuclear Proteins; D012333:RNA, Messenger; D051879:Twist-Related Protein 1; C067250:Twist1 protein, mouse