Trisomy 13 in a case of myelofibrosis with myeloid metaplasia with early blastic transformation.
We describe a case of early myeloid blastic transformation in a 64-year-old man suffering from myelofibrosis with myeloid metaplasia. Both chronic and blastic phase cytogenetic analysis showed trisomy 13 to be the sole chromosome aberration. A potential role for this rare abnormality in determining such an unusually poor clinical outcome is discussed.
Ferrara
F
F
Divisione di Ematologia, Ospedale Cardarelli, Naples, Italy.
Vicari
L
L
Festa
B
B
Di Noto
R
R
Pane
F
F
Sebastio
L
L
Cimino
R
R
D001752:Blast Crisis / Q000473:pathology; D002882:Chromosomes, Human, Pair 13; D017809:Fatal Outcome; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D014314:Trisomy; D051941:fms-Like Tyrosine Kinase 3
D011518:Proto-Oncogene Proteins; C497970:FLT3 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3