title: CD-44: a marker of metastases of head and neck melanomas.
abstract: Specimens of 38 melanomas of the oral cavity and facial skin and 23 lymph nodes with melanoma metastases were stained immunohistochemically for the presence of variants 5, 6, 7 and 8 of CD-44 antigen. A positive reaction was observed only for variant 7-8 in primary melanomas as well as in lymph nodes with metastases from melanoma. The CD-44 score (percentage of CD-44 positive cells chi intensity of reaction) correlated with metastatic behaviour of tumours and was greater in metastatic lymph nodes than in primary tumours.
authors.affiliation: Department of Pathology, Georg August University Göttingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Korabiowska
authors.forename: U
authors.initials: U
authors.lastname: Brinck
authors.forename: J
authors.initials: J
authors.lastname: Hönig
authors.forename: O
authors.initials: O
authors.lastname: Mora
authors.forename: S
authors.initials: S
authors.lastname: Bartkowski
authors.forename: A
authors.initials: A
authors.lastname: Schauer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000556:secondary*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000556:secondary
chemical_list: D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors