Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by oxidized and reduced lipoic acid.
Peroxynitrite, formed by combination of superoxide radical with nitric oxide, is a reactive tissue-damaging species apparently involved in the pathology of several human diseases. Peroxynitrite nitrates tyrosine residues and inactivates alpha 1-antiproteinase. We show that both lipoic acid and dihydrolipoic acid efficiently protect against damage by peroxynitrite. By contrast, other disulphides tested did not. The biological antioxidant effects of lipoate/dihydrolipoate may involve scavenging of reactive nitrogen species as well as reactive oxygen species.
Whiteman
M
M
Neurodegenerative Disease Research Centre, King's College, London, UK.
Tritschler
H
H
Halliwell
B
B
D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009566:Nitrates / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014443:Tyrosine / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D000975:Antioxidants; D016166:Free Radical Scavengers; D009566:Nitrates; D017382:Reactive Oxygen Species; D000515:alpha 1-Antitrypsin; C039642:peroxynitric acid; D009569:Nitric Oxide; D014443:Tyrosine; D008063:Thioctic Acid; C015144:dihydrolipoic acid