[Epidermal growth factor (EGF) can induce prostatic buds in the absence of androgens].
We have investigated the prostatic bud induction in the urogenital sinus of fetal rats and mice when the sinuses were cultured with non-androgenic growth factors, and found that epidermal growth factor (EGF) as well as transforming growth factor-alpha (TGF-alpha) powerfully induces the prostatic buds in the absence of androgens even in the androgen-receptor-deficient Tfm sinuses. Immunofluorescence study revealed that endogenous EGF and EGF receptor exist in the sinus mesenchyme of 19.5-day fetal male rats, where many prostatic buds are appearing.
Saito
M
M
Département de Biologie, Faculté des Sciences pharmaceutiques, Teikyo Université, Kanagawa-Ken, Japan.
Mizuno
T
T
D000818:Animals; D004815:Epidermal Growth Factor / Q000032:analysis / Q000494:pharmacology*; D066246:ErbB Receptors / Q000032:analysis; D005455:Fluorescent Antibody Technique; D008297:Male; D051379:Mice; D011467:Prostate / Q000187:drug effects / Q000196:embryology*; D051381:Rats; D017208:Rats, Wistar; D016211:Transforming Growth Factor alpha / Q000494:pharmacology; D014566:Urogenital System / Q000737:chemistry / Q000196:embryology
D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor; D066246:ErbB Receptors
Le facteur de croissance de l'épiderme (EGF) peut induire des bourgeons prostatiques en l'absence d'androgènes.