title: The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.
abstract: The melanoma antigen gene (MAGE) family comprises 12 known genes, of which 6 are expressed in tumors. In the course of a systematic analysis of transcripts in Xq28, we have identified cDNAs related to different MAGE genes. Analysis of cell hybrids, ordered YACs, and cosmids showed that all MAGE genes are located in Xq28 and are clustered in three main intervals within 3.5 Mb. The six genes expressed in tumors are contained in the two intervals closest to the telomere and are highly homologous to each other. Analysis of different species suggests that human MAGE sequences are conserved in primates, but less well conserved in other vertebrate species.
authors.affiliation: Deutsches Krebsforschungszentrum, Abteilung Molekulare Genomanalyse, Heidelberg, Germany.
authors.forename: U C
authors.initials: UC
authors.lastname: Rogner
authors.forename: K
authors.initials: K
authors.lastname: Wilke
authors.forename: E
authors.initials: E
authors.lastname: Steck
authors.forename: B
authors.initials: B
authors.lastname: Korn
authors.forename: A
authors.initials: A
authors.lastname: Poustka
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D016466:CHO Cells; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D017124:Conserved Sequence; D003360:Cosmids; D006224:Cricetinae; D016172:DNA Fingerprinting; D018076:DNA, Complementary; D005091:Exons; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000276:immunology; D058950:Melanoma-Specific Antigens; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011323:Primates; D012689:Sequence Homology, Nucleic Acid; D014714:Vertebrates; D014960:X Chromosome
chemical_list: D000951:Antigens, Neoplasm; D018076:DNA, Complementary; C072011:MAGEA1 protein, human; C072013:MAGEA3 protein, human; C095204:MAGEA4 protein, human; C095203:MAGEA6 protein, human; C072012:MAGEB2 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins