title: [Fibrin fragment beta 15-118. Inhibitory and complex-forming properties].
abstract: Peptide beta 15-118 isolated from desAABB-NDSK preserves fibrin polymerization active site "B", inhibits polymerization process at 12 degrees C, eliminates the inhibitory properties of plasmin D-D-fragment but does not influence inhibitory properties of a D-monomer fragment. Complex formation between peptide beta 15-118 and both D- and D-D fragments was electrophoretically demonstrated. Peptide beta 15-118 forms more stable complex with the D-D fragment which does not dissociate in the medium of polymerizing fibrin as the complex of the peptide with monomer D fragment does. Gel filtration data confirm dimerization of D-monomer fragments after their complexing with beta 15-118. This phenomenon suggests that mutual affinity of D-domains in fibrin increases after loci interactions of the "B"-"b" type.
authors.forename: E V
authors.initials: EV
authors.lastname: Lugovskoĭ
authors.forename: V S
authors.initials: VS
authors.lastname: Chudnovets
authors.forename: E M
authors.initials: EM
authors.lastname: Makogonenko
authors.forename: S G
authors.initials: SG
authors.lastname: Derzskaia
authors.forename: G K
authors.initials: GK
authors.lastname: Gogolinskaia
authors.forename: L I
authors.initials: LI
authors.lastname: Mikhalovskaia
authors.forename: S V
authors.initials: SV
authors.lastname: Komissarenko
mesh_terms: D000933:Antifibrinolytic Agents / Q000737:chemistry*; D001704:Biopolymers; D001782:Blood Donors; D002850:Chromatography, Gel; D005337:Fibrin / Q000737:chemistry*; D005338:Fibrin Fibrinogen Degradation Products / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D011485:Protein Binding
chemical_list: D000933:Antifibrinolytic Agents; D001704:Biopolymers; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C036309:fibrin fragment D; C097636:fibrin fragment beta (15-118); D005337:Fibrin
vernacular_title: Fibrinovyĭ fragment beta 15-118. Ingibitornye i kompleksoobrazuiushchie svoĭstva.