title: Acquired von Willebrand's syndrome causing a hemorrhagic diathesis in a patient with hypothyroidism.
abstract: The occurrence of bleeding diathesis with menorrhagia and easy bruising may occur in patients with moderate to severe hypothyroidism sometimes linked to acquired von Willebrand's disease (VWD). We describe a patient with profound hypothyroidism in whom the diagnosis of hypothyroidism was established while evaluating uncontrolled gingival bleeding after a dental procedure. Thyroid hormone replacement led to a rise in von Willebrand factor, factor VIIIC, and a significant fall in the elevated bleeding time from 15 to 8 min. Acquired von Willebrand's disease is an unusual manifestation of hypothyroidism and is reversible.
authors.affiliation: Don Monti Division of Oncology, Department of Medicine, North Shore University Hospital/Cornell University Medical College, Manhasset, New York 11030, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Attivissimo
authors.forename: S M
authors.initials: SM
authors.lastname: Lichtman
authors.forename: I
authors.initials: I
authors.lastname: Klein
mesh_terms: D000328:Adult; D005884:Gingival Hemorrhage / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D013974:Thyroxine / Q000627:therapeutic use; D014081:Tooth Extraction; D014842:von Willebrand Diseases / Q000150:complications* / Q000175:diagnosis
chemical_list: D013974:Thyroxine