[Bioavailability and pharmacodynamics of various forms of synthetic beta-carotene in volunteers].
The biological availability of artificial beta-carotene as a water-soluble versus oily formulation based on cyclodextrin (Cyclocar tablets) was studied on volunteers given a single dose of 25 mg. The concentrations of beta-carotene and major carotenoids were measured in the blood serum during the experiment by high performance liquid chromatography. The maximum content of beta-carotene in the serum was attained 24-30 and 30-48 hrs after oily formulations and Cyclocar and were 48.0 +/- 7.7 and 28.1 +/- 3.6 mg/dl, respectively. The rate of beta-carotene utilization from Cyclocar was 2.2 times less than that from the oil paste. Besides, beta-carotene absorbed from these oily drugs retained in the blood serum for longer period than that form Cyclocar.
Iakushina
L M
LM
Malakhova
E A
EA
Shkarina
T N
TN
Poznanskaia
A A
AA
Spirichev
V B
VB
D000328:Adult; D000368:Aged; D001682:Biological Availability; D002338:Carotenoids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004304:Dosage Forms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D019207:beta Carotene
D004304:Dosage Forms; D019207:beta Carotene; D002338:Carotenoids
Izuchenie biodostupnosti i farmakodinamiki razlichnykh form sinteticheskogo beta-karotina na dobrovol'tsakh.