Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.
A fundamental question in the basic biology of aging is whether there is a universal aging process. If indeed such a process exists, one would expect that it develops at a higher rate in short- versus long-lived species. We have quantitated pentosidine, a marker of glycoxidative stress in skin collagen from eight mammalian species as a function of age. A curvilinear increase was modeled for all species, and the rate of increase correlated inversely with maximum life-span. Dietary restriction, a potent intervention associated with increased life-span, markedly inhibited glycoxidation rate in the rodent. On the assumption that collagen turnover rate is primarily influenced by the crosslinking due to glycoxidation, these results suggest that there is a progressive age-related deterioration of the process that controls the collagen glycoxidation rate. Thus, the ability to withstand damage due to glycoxidation and the Maillard reaction may be under genetic control.
Sell
D R
DR
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Lane
M A
MA
Johnson
W A
WA
Masoro
E J
EJ
Mock
O B
OB
Reiser
K M
KM
Fogarty
J F
JF
Cutler
R G
RG
Ingram
D K
DK
Roth
G S
GS
Monnier
V M
VM
D000375:Aging; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry; D002417:Cattle; D003094:Collagen / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004032:Diet; D004285:Dogs; D005947:Glucose / Q000737:chemistry; D006801:Humans; D008136:Longevity; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry; D008253:Macaca mulatta; D010084:Oxidation-Reduction; D051381:Rats; D012044:Regression Analysis; D012453:Saimiri; D012867:Skin / Q000737:chemistry; D013552:Swine
D003432:Cross-Linking Reagents; D003094:Collagen; D001120:Arginine; C062187:pentosidine; D005947:Glucose; D008239:Lysine