[The preliminary results of a study of the role of endogenous nitric oxide in pregnant women with chronic glomerulonephritis, hypertension and puerperal eclampsia].
NO-synthase activity and formation of ERP/NO were evaluated in 19 pregnant women by high activity of platelet guanylate-cyclase (GC) and presence of z-arginine. The examinees were divided into 4 groups: 3 women with chronic glomerulonephritis (CGN), 9 patients with essential hypertension (EH), 3 nonpregnant women of reproductive age with EH, 3 healthy pregnant women. One patient had puerperal eclampsia. Z-arginine activation failed to change GC activity in healthy pregnant women, reduced it in pregnant and nonpregnant women with EH, increased GC activity 1.6-fold in a patient with puerperal eclampsia and in CGN pregnant females. It is inferred that changes in NO-dependent synthesis of cGMP manifested more distinctly in a patient with puerperal eclampsia.
Zozulia
O V
OV
Rogov
V A
VA
Belushkina
N N
NN
Riaposova
I K
IK
Beĭlin
A L
AL
Dzgoeva
F U
FU
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D002908:Chronic Disease; D004461:Eclampsia / Q000097:blood*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011644:Puerperal Disorders / Q000097:blood*
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase
Predvaritel'nye rezul'taty izucheniia roli éndogennogo oksida azota u beremennykh s khronicheskim glomerulonefritom, gipertonicheskoĭ bolezn'iu, rodovoĭ éklampsieĭ.