Effect of blood transfusion and cyclophosphamide on cardiac allograft survival in sensitized mice.
In the H-2-incompatible donor-recipient model in mice (BALB/c-->CBA/H), combination of donor-specific blood transfusion (DST) on the day -9 before transplantation with both pre- and posttransplant immunosuppression with cyclophosphamide (CY) interacted beneficially to produce significant donor-specific prolongation of cardiac graft survival. However, in recipients presensitized with donor-specific blood on the day -21, combination of DST with pre- and posttransplant CY immunosuppression did not act synergistically and graft survival in this group did not differ from that in presensitized mice treated with 2 doses of CY alone.
Lasek
W
W
Department of Immunology, Medical Academy, Warsaw, Poland.
Sora
M
M
Jakóbisiak
M
M
D000818:Animals; D001803:Blood Transfusion; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology*; D007114:Immunization; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide