[Concentrate of coagulation factor IX: viral validation of the thermoinactivation process].
The coagulation factor IX obtained at the Institute of Haematology and Transfusion in Warsaw was subjected to virological validation. Two lipide enveloped viruses were used: HSV-1 and Sindbis which may be a model for the viruses of B and C types in hepatitis. It was shown that heating of the freeze-drying preparations at 80 degrees C during 72 hrs leads to full inactivation of the added model viruses.
Zahorska
R
R
Centralne Laboratorium Surowic i Szczepionek w Warszawie.
Buchowicz
I
I
Ejduk
A
A
D001688:Biological Products / Q000592:standards*; D005164:Factor IX / Q000592:standards*; D006361:Heating; D018139:Simplexvirus / Q000302:isolation & purification*; D012845:Sindbis Virus / Q000302:isolation & purification*; D013242:Sterilization / Q000379:methods*
D001688:Biological Products; D005164:Factor IX
Koncentrat czynnika IX krzepniecia krwi: walidacja wirusologiczna procesu termoinaktywacji.