Acute graft-versus-host disease of the gut.
A 28-year-old man with acute promyelocytic leukemia at first early relapse received HLA-matched allogenic bone marrow transplantation (BMT) at first early relapse. Cyclosporin A and methotrexate were administered at conventional doses as a prophylaxis for graft-versus-host disease (GVHD). He presented with severe bloody diarrhea on day 87 after BMT. Examination of the lower gastrointestinal tract revealed diffuse mucosal change of inflammation. A diagnosis of late onset of acute gut GVHD was made, in the absence of other manifestations such as skin and liver involvement. A further survey is needed to clarify the incidence and the pathogenesis of atypical gut GVHD.
Izumi
T
T
Department of Medicine, Jichi Medical School Hospital, Tochig.
Amemiya
Y
Y
Iwao
N
N
Suzuki
T
T
Muroi
K
K
Yoshida
M
M
Hatake
K
K
Miura
Y
Y
Hitomi
N
N
Hatakeyama
M
M
D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003092:Colitis / Q000175:diagnosis / Q000209:etiology*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000628:therapy*; D008297:Male