title: The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease.
abstract: Cognitive and noncognitive psychiatric symptoms were systematically evaluated in 21 patients with Alzheimer's disease by using the Neurobehavioral Rating Scale. Regional cerebral metabolic activity was measured in each patient by [18F]fluorodeoxyglucose PET. Significant correlations emerged between global cortical metabolic activity and the Agitation/Disinhibition factor score, Cognition factor score, and total score. Relationships between noncognitive symptoms and metabolic activity were regionally specific, with significant correlations between Agitation/Disinhibition factor score and metabolism in the frontal and temporal lobes, between Psychosis factor score and metabolism in the frontal lobe, and between Anxiety/Depression factor score and metabolism in the parietal lobe. These results suggest that psychiatric symptoms are fundamental expressions of the cortical dysfunction of Alzheimer's disease.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Sultzer
authors.forename: M E
authors.initials: ME
authors.lastname: Mahler
authors.forename: M A
authors.initials: MA
authors.lastname: Mandelkern
authors.forename: J L
authors.initials: JL
authors.lastname: Cummings
authors.forename: W G
authors.initials: WG
authors.lastname: Van Gorp
authors.forename: C H
authors.initials: CH
authors.lastname: Hinkin
authors.forename: M A
authors.initials: MA
authors.lastname: Berisford
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000523:psychology; D001143:Arousal / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose