Is median thoracic artery a target organ artery for estradiol and progesterone? A comparison with uterine artery.
OBJECTIVE
The aim of this study was to show the parallel evolution of the pulsatility index of the uterine artery and the one of the median thoracic artery.


METHODS
The study involved seven volunteer women, below 38, suffering from premature ovarian failure, who received E2 and progesterone replacement therapy. Plasma levels of E2, progesterone, follicle stimulating hormone and luteinizing hormone were measured and PI were studied and compared before treatment and on Days 13, 27 and 41.


RESULTS
Before treatment, a high-resistance vascular for both arteries is uniformly found. The curves show with the increasing of the E2 plasma levels, a decrease in the PI of UA and MTA with a fall at Day 13. We compared the mean values in MTA and UA PI. No statistical difference between the three mean values in PI obtained at Day -1, Day 13 and Day 41 was demonstrated.


CONCLUSIONS
The results suggest that median thoracic artery is a target organ artery. Such as the UA, the MTA vascular resistance is according to the variations of plasma levels of E2. In consideration of it rectilinear and superficial type, this led us to study this artery when we use different sorts of replacement therapy, and particularly in the oocyte donation program.
Guis
F
F
Department of Obstetrics and Gynecology, Hôpital A. Béclère, Clamart, France.
Letur-Könirsch
H
H
Vincent
Y
Y
Olivennes
F
F
Fernandez
H
H
Frydman
R
R
D000328:Adult; D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000592:standards; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000188:drug therapy; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D011863:Radioimmunoassay; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013895:Thoracic Arteries / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D018617:Ultrasonography, Doppler, Pulsed; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone