title: Trisomy 13 in a case of myelofibrosis with myeloid metaplasia with early blastic transformation.
abstract: We describe a case of early myeloid blastic transformation in a 64-year-old man suffering from myelofibrosis with myeloid metaplasia. Both chronic and blastic phase cytogenetic analysis showed trisomy 13 to be the sole chromosome aberration. A potential role for this rare abnormality in determining such an unusually poor clinical outcome is discussed.
authors.affiliation: Divisione di Ematologia, Ospedale Cardarelli, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: L
authors.initials: L
authors.lastname: Vicari
authors.forename: B
authors.initials: B
authors.lastname: Festa
authors.forename: R
authors.initials: R
authors.lastname: Di Noto
authors.forename: F
authors.initials: F
authors.lastname: Pane
authors.forename: L
authors.initials: L
authors.lastname: Sebastio
authors.forename: R
authors.initials: R
authors.lastname: Cimino
mesh_terms: D001752:Blast Crisis / Q000473:pathology; D002882:Chromosomes, Human, Pair 13; D017809:Fatal Outcome; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D014314:Trisomy; D051941:fms-Like Tyrosine Kinase 3
chemical_list: D011518:Proto-Oncogene Proteins; C497970:FLT3 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3