Short report: pefloxacin does not potentiate quinine efficacy against Plasmodium falciparum malaria.
Twenty-four patients presenting with severe Plasmodium falciparum infection at the Kamenge Hospital in Burundi were enrolled in a double-blind study comparing the efficacy of a seven-day regimen of intravenous quinine alone or in combination with pefloxacin. The aim of this study was to assess whether pefloxacin modified chloroquine efficacy or its uptake by infected erythrocytes as shown with other antimalarials. Pefloxacin did not modify the antimalarial activity of quinine, in terms of speed of parasite or fever clearance. Moreover, pefloxacin does not appear to interact with quinine uptake by erythrocytes in humans.
Deloron
P
P
Institut Natiional de la Sante et de la Recherche Medicale (INSERM) Unite 13, Institut de Medecine et d'Epidemiologie Africaines (IMEA), Paris, France.
Aubry
P
P
Ndayirabije
A
A
Clavier
F
F
Verdier
F
F
D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000962:Antimalarials / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D006801:Humans; D007275:Injections, Intravenous; D016778:Malaria, Falciparum / Q000188:drug therapy*; D018512:Parasitemia / Q000188:drug therapy; D015366:Pefloxacin / Q000494:pharmacology / Q000627:therapeutic use*; D010963:Plasmodium falciparum / Q000187:drug effects; D011803:Quinine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D000962:Antimalarials; D015366:Pefloxacin; D011803:Quinine