title: [The biochemical screening of Down's syndrome].
abstract: Since the initial observation of an association between low maternal serum aFP and trisomies noninvasive for chromosomal abnormalities is an obvious goal of genetics and obstetricians. Here are reported the results of a biochemical screening for fetal trisomies study based on the dosages of maternal serum aFP, bHCG and uE3 at 16 week gestational age on 1166 pregnant women without risk factors for genetical abnormalities. Sensitivity, positive predictivity and negative predictivity of the screening were 50%, 42.86% and 99.74% respectively.
authors.affiliation: Divisione di Ostetricia e Ginecologia, USSL n. 75.VI, Ospedale Vittore Buzzi, Milano.
authors.forename: S
authors.initials: S
authors.lastname: Beolchi
authors.forename: M
authors.initials: M
authors.lastname: Fadin
authors.forename: A
authors.initials: A
authors.lastname: Paganelli
authors.forename: C I
authors.initials: CI
authors.lastname: Brambilla
authors.forename: C
authors.initials: C
authors.lastname: Messina
authors.forename: C
authors.initials: C
authors.lastname: Morandi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D004314:Down Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D004964:Estriol / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004964:Estriol
vernacular_title: Screening biochimico della sindrome di Down.