Compartmental organization of calretinin in the rat striatum.
The present study examined the compartmental distribution of a calcium-binding protein, calretinin, in the rat striatum. Calretinin-immunoreactive cells were homogeneously scattered throughout the striatum, but calretinin-immunoreactive fibers were clustered as patches in the medial, central and ventral caudoputamen and in the lateral nucleus accumbens. These patches corresponded to striosomes, identified by immunostaining for calbindin-D28 K in adjacent sections. In the medial nucleus accumbens, calretinin-immunoreactive fibers showed diffuse distribution with occasional islands of calretinin-poor zones. These islands contained tightly packed, Nissl-stained cells, which have been previously shown to correspond to mu-opiate receptor-rich patches. Calretinin-positive fibers fill striosomes/patches in the caudoputamen and in the lateral nucleus accumbens and avoid them in the medial nucleus accumbens.
Hiroi
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N
McGill University, Department of Psychology, Montreal, Que., Canada.
D000818:Animals; D064032:Calbindin 2; D064026:Calbindins; D002421:Caudate Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D007158:Immunologic Techniques; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D011699:Putamen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013194:Staining and Labeling; D014018:Tissue Distribution
C576512:Calb2 protein, rat; D064032:Calbindin 2; D064026:Calbindins; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G