title: Physiological and toxicological actions of nitric oxide in the central nervous system.
abstract: NO has clearly revolutionized our thinking about aspects of neurotransmission and neuronal signaling. It has also radically altered our thoughts about how synaptic transmission takes place. NO is emerging as an important regulator of a variety of physiological processes; however, under certain conditions of excessive formation, NO is emerging as an important mediator of pathological nervous tissue damage. Understanding the role of NO in these processes will hopefully lead to the development of selective therapeutic agents and to a better understanding of basic processes underlying normal and pathological neuronal functions.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: V L
authors.initials: VL
authors.lastname: Dawson
authors.forename: T M
authors.initials: TM
authors.lastname: Dawson
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology* / Q000633:toxicity*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase