p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.
p59fyn is an Src family nonreceptor tyrosine kinase that has been suggested to play an important role in T-cell development and function. p125FAK is a unique nonreceptor tyrosine kinase and has been known to respond to integrin-extracellular matrix interactions. To examine their roles in thymocytes, heterozygous fak mutation was introduced into homozygous Fyn deficiency. The double mutation, but neither Fyn deficiency nor FAK heterozygosity alone, displayed impaired development of CD4+CD8+ thymocytes with atrophy of the thymic cortex, suggesting a unique cooperation between p59fyn and p125FAK in CD4+CD8+ T-cell development.
Kanazawa
S
S
Department of Morphogenesis, Kumamoto University School of Medicine, Japan.
Ilić
D
D
Hashiyama
M
M
Noumura
T
T
Yamamoto
T
T
Suda
T
T
Aizawa
S
S
D000818:Animals; D001284:Atrophy; D001483:Base Sequence; D015704:CD4 Antigens; D016827:CD8 Antigens; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002454:Cell Differentiation; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D005838:Genotype; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000172:deficiency / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000502:physiology*; D051076:Proto-Oncogene Proteins c-fyn; D016176:T-Lymphocyte Subsets / Q000166:cytology*; D013950:Thymus Gland / Q000473:pathology
D015704:CD4 Antigens; D016827:CD8 Antigens; D015815:Cell Adhesion Molecules; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn; C496051:Ptk2 protein, mouse