title: Interferon treatment of chronic active hepatitis C in patients with end-stage chronic renal failure.
abstract: Alpha interferon has been shown to be effective in the treatment of chronic hepatitis C virus infection. We studied the efficacy of alpha 2a-interferon in chronic active hepatitis C patients with end-stage chronic renal failure (CRF). Thirteen patients with CRF and 12 patients with a normal renal function were included in the study. The patients received interferon 3 million units three times a week subcutaneously for 6 months. All patients with CRF and 6 patients without CRF had a complete response, defined as a decline in serum alanine aminotransferase levels to the normal range. One patient had a decrease in alanine aminotransferase of more than 50%, and 5 patients were nonresponders. A relapse was observed in 4 patients with and in 4 without CRF. Three patients had renal transplantation, and the alanine aminotransferase levels were normal after 12-14 months. This preliminary study shows that interferon is effective in the treatment of patients with chronic hepatitis C and CRF.
authors.affiliation: Department of Internal Medicine, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ozyilkan
authors.forename: H
authors.initials: H
authors.lastname: Simşek
authors.forename: B
authors.initials: B
authors.lastname: Uzunalimoğlu
authors.forename: H
authors.initials: H
authors.lastname: Telatar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000150:complications / Q000201:enzymology / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000150:complications / Q000201:enzymology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000201:enzymology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D016898:Interferon-alpha; D000410:Alanine Transaminase