title: Effect of chemotherapy on growth.
abstract: Growth restriction has been demonstrated clearly following the treatment of childhood malignancies, even in the absence of irradiation to the hypothalamic-pituitary axis. The use of CT and spinal irradiation in the original treatment of brain tumours has a marked effect on growth. This effect is most profound in children who have received both treatments and cannot be overcome using GH therapy at conventional doses.
authors.affiliation: Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Ogilvy-Stuart
authors.forename: S M
authors.initials: SM
authors.lastname: Shalet
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents