The effect of Toremifene on the expression of some genes in human mononuclear cells.
Toremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells. After short-term, in vitro exposure to therapeutical levels, distinct changes in P-glycoprotein, steroid receptors, p53 and Bcl-2 expression take place. In view of the increasing use of antiestrogens in cancer therapy and prevention, there is obvious merit in long-term in vivo studies to be conducted.
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Sunnybrook Health Science Centre, Department of Clinical Biochemistry, University of Toronto, Ontario, Canada.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects / Q000235:genetics; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D011505:Protein-Tyrosine Kinases / Q000187:drug effects / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000187:drug effects / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2; D011987:Receptors, Steroid / Q000187:drug effects / Q000235:genetics; D017312:Toremifene / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018931:Antineoplastic Agents, Hormonal; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011987:Receptors, Steroid; D016159:Tumor Suppressor Protein p53; D017312:Toremifene; D011505:Protein-Tyrosine Kinases