In vitro models of the blood-brain barrier to study bacterial meningitis.
In vitro models of the blood-brain barrier involving culturing cerebral microvascular endothelial cells may provide information critical to understanding diseases of the central nervous system, such as bacterial meningitis, that would be difficult to obtain from clinical studies or from in vivo models. These models may also identify targets for therapeutic intervention.
Townsend
G C
GC
Dept of Internal Medicine, University of Virginia, Charlottesvilled 22908, USA. gct2r@virginia.edu
Scheld
W M
WM
D000818:Animals; D001812:Blood-Brain Barrier; D006801:Humans; D016920:Meningitis, Bacterial / Q000503:physiopathology*; D008954:Models, Biological