Development of IgG subclasses in healthy Polish children.
To determine the ontogeny of IgG subclasses in healthy Polish children IgG1, IgG2, IgG3, IgG4 concentrations were measured by enzyme-linked immunosorbent assay in 30 cord blood sera and sera from 152 healthy children aged 4 months to 16 years. The geometric mean of concentrations all of IgG subclasses in age-related groups of children were calculated. In cord sera, four IgG subclasses were found with the IgG1 level reaching about 90%, IgG2--52%, IgG3--80% and IgG4--33% of the mean adult values. In the group of youngest children (4-6 months of age) the concentration of all IgG subclasses were significantly decreased in comparison to initial values. Then, IgG1 and IgG3 levels increased rapidly reaching ca. 50% of the mean adult values by 1 year of age. We also demonstrated much slower maturation of IgG2 and IgG4 which lagged behind IgG1 and IgG3 development, especially in younger children.
Gregorek
H
H
Department of Immunology, Child Health Center, Warsaw, Poland.
Imielska
D
D
Gornicki
J
J
Mikołajewicz
J
J
Przeradzka
B
B
Madaliński
K
K
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011044:Poland; D012016:Reference Values
D007074:Immunoglobulin G