The protective effect of inhaled terbutaline, sodium cromoglycate and budesonide on exercise-induced asthma in children.
The effect of single-dose inhaled terbutaline, sodium cromo-glycate and budesonide were compared with control in 11 exercise-induced asthma (EIA) patients, aged 9-14 years. Patients exercise for 6 minutes, 15 minutes after inhaling drugs. The FVC, FEV1, PEFR and MMEF were recorded before exercise and after exercise at 5 minutes interval up to 25 minutes. After exercise, the mean (SEM) maximal percentage fall in FEV1 after placebo, 200 micrograms of terbutaline, 10 mg of sodium cromoglycate, and 100 micrograms of budesonide were 22.81 (3.45), 4.05 (2.11), 11.29 (1.18), and 20.36 (2.33) respectively. It was concluded that single-dose inhaled terbutaline and sodium cromoglycate resulted in a significant protective effect on exerxide-induced asthma whereas budesonide did not.
Pichaipat
V
V
Department of Pediatrics, Maharat Nakhon Ratchasima Hospital, Thailand.
Tongpenyai
Y
Y
Nerntong
T
T
Sriprapachiranont
C
C
D000280:Administration, Inhalation; D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001250:Asthma, Exercise-Induced / Q000517:prevention & control*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019819:Budesonide; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D011282:Pregnenediones / Q000008:administration & dosage / Q000627:therapeutic use*; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D011282:Pregnenediones; D019819:Budesonide; D013726:Terbutaline; D004205:Cromolyn Sodium