Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation.
The most well-described renal disease associated with hepatitis B virus (HBV) infection is membranous glomerulonephritis; membranoproliferative glomerulonephritis is described much less frequently. The course of HBV-associated renal disease after liver transplantation has not been described to date. We present a 15-year-old girl with HBV-associated membranoproliferative glomerulonephritis and end-stage liver disease, in whom, after cadaver liver transplantation, clinical and histological resolution of renal disease was observed. Resolution was associated with diminution of circulating HBV surface antigen levels.
Quan
A
A
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75235-9063, USA.
Portale
A
A
Foster
S
S
Lavine
J
J
D000293:Adolescent; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000628:therapy / Q000821:virology*; D006509:Hepatitis B / Q000150:complications* / Q000209:etiology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*