title: Scintigraphic measurement of uterine clearance in normal mares and mares with recurrent endometritis.
abstract: The percentage of Technetium 99m-albumin colloid (99mTc-microAA), a radiocolloid, cleared from the uterine lumen within 4 h of intrauterine infusion, was measured in 15 mares during 2 consecutive cycles, on Day 3 of oestrus and 48 h after ovulation. Four nulliparous (Group 1) and 4 multiparous (Group 2) mares were classified as resistant and the remaining 7 multiparous mares were classified as susceptible (Group 3) to endometritis. Mares in Groups 1 and 2 cleared more 99mTc-microAA from their uteri than did mares in Group 3 during oestrus (P < 0.01) and 48 h after ovulation (P < 0.001). In the Group 1 + 2 mares, > 50% of the colloid was cleared in 7 and none in the remaining mare, apparently related to lack of cervical relaxation. Mean percentage of 99mTc-microAA cleared by Group 3 mares was negligible (< 5%), but some 99mTc-microAA was cleared by 3 of the 7 mares during 4 of the 6 studies conducted. Clearance of radiocolloid infused into the uterus of 3 reproductively normal mares during dioestrus was negligible. 99mTc-microAA infused into the uterus did not adversely affect endometrial integrity as determined by endometrial biopsy. Mares tolerated the procedures well. We conclude that scintigraphy can be used to detect impaired mechanical clearance of the uterus: reproductively normal mares clear > 50% 99mTc-microAA within 2 h of infusion whereas those susceptible to endometritis or mares with poor cervical dilatation may exhibit delayed uterine clearance.
authors.affiliation: University of Florida, College of Veterinary Medicine, Department of Large Animal Clinical Sciences, Gainesville 32610, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: LeBlanc
authors.forename: L
authors.initials: L
authors.lastname: Neuwirth
authors.forename: A C
authors.initials: AC
authors.lastname: Asbury
authors.forename: T
authors.initials: T
authors.lastname: Tran
authors.forename: D
authors.initials: D
authors.lastname: Mauragis
authors.forename: E
authors.initials: E
authors.lastname: Klapstein
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004716:Endometritis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000662:veterinary*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006734:Horse Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D006736:Horses / Q000378:metabolism*; D011877:Radionuclide Imaging; D012008:Recurrence; D013668:Technetium Tc 99m Aggregated Albumin; D014599:Uterus / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin