Production of interleukin-5 and the suppressive effect of cyclosporin A in childhood severe atopic dermatitis.
A child with severe atopic dermatitis had marked improvement with oral cyclosporin A (CyA) therapy. The function of activated T lymphocytes and serum interleukin-5 concentrations were reduced. The expression and production of interleukin-5 were high, but were suppressed during CyA therapy and by CyA in vitro. Oral CyA therapy may be useful for severe atopic dermatitis.
Ishii
E
E
Division of Pediatrics, Saga Prefectural Hospital Koseikan, Saga, Japan.
Yamamoto
S
S
Sakai
R
R
Hamasaki
Y
Y
Miyazaki
S
S
D002675:Child, Preschool; D016572:Cyclosporine / Q000494:pharmacology* / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D015848:Interleukin-5 / Q000096:biosynthesis / Q000097:blood*; D008297:Male
D016207:Cytokines; D015848:Interleukin-5; D016572:Cyclosporine