title: Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.
abstract: The effect of hyperbaric oxygen (HBO) as an immunosuppressive agent was evaluated by using a highly immunogenic skin allograft mouse model. Immune-histoincompatible female C57BL/6 and BALB/c mice (N = 30) were randomly assigned to three groups receiving no treatment (control group), low dose HBO treatment (two treatments once a week), and intermediate HBO treatment (two treatments 3 times/wk) 1 wk before and 2 wk after transplantation of a 1.5 x 2 cm full thickness skin allograft from the back. Rejection was observed a Day 7 and was completed 14 days after surgery in controls. Low dose and intermediate HBO treatment delayed skin allograft rejection, which was histologically confirmed.
authors.affiliation: Department of Surgery, Southern Illinois University-School of Medicine, Springfield 63702-9230, USA.
authors.forename: D
authors.initials: D
authors.lastname: Erdmann
authors.forename: A C
authors.initials: AC
authors.lastname: Roth
authors.forename: J
authors.initials: J
authors.lastname: Hussmann
authors.forename: S F
authors.initials: SF
authors.lastname: Lyons
authors.forename: N J
authors.initials: NJ
authors.lastname: Mody
authors.forename: J O
authors.initials: JO
authors.lastname: Kucan
authors.forename: R C
authors.initials: RC
authors.lastname: Russell
mesh_terms: D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006931:Hyperbaric Oxygenation; D007121:Immunocompetence; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011897:Random Allocation; D013524:Surgical Flaps