title: A new rat model for studying the calpain-calpastatin system.
abstract: A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.
authors.affiliation: Department of Sciences and Biomedical Technologies, University of Milan, Italy.
authors.forename: L P
authors.initials: LP
authors.lastname: Soldati
authors.forename: B R
authors.initials: BR
authors.lastname: Barber
authors.forename: S
authors.initials: S
authors.lastname: Salardi
authors.forename: I
authors.initials: I
authors.lastname: Molinari
authors.forename: G
authors.initials: G
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D002154:Calpain / Q000502:physiology*; D003433:Crosses, Genetic; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics / Q000502:physiology*; D005260:Female; D005838:Genotype; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D002135:Calcium-Binding Proteins; D015853:Cysteine Proteinase Inhibitors; C033668:calpastatin; D002154:Calpain