Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report.
Twenty ASA I-II patients received either 2 or 3 x ED95 doses of rocuronium bromide during nitrous oxide, oxygen, propofol, fentanyl-based anaesthesia. The mean times to maximum block were 98 s and 74 s and the mean duration of clinical relaxation (recovery to 25% T1) was 35 min and 46 min following 620 micrograms kg-1 and 930 micrograms kg-1, respectively. Neuromuscular blockade was antagonized with either neostigmine or edrophonium from a twitch height of 25%. Although there was no significant difference between the recovery times neostigmine appeared to give more consistent antagonism of rocuronium-induced blockade.
Davis
L
L
Anaesthetics Unit, Royal London Hospital, UK.
Jayarajah
M J
MJ
Toner
C C
CC
Flynn
P J
PJ
D000293:Adolescent; D000328:Adult; D000732:Androstanols / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000758:Anesthesia; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004311:Double-Blind Method; D004491:Edrophonium / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000077123:Rocuronium; D013997:Time Factors
D000732:Androstanols; D002800:Cholinesterase Inhibitors; D003473:Neuromuscular Nondepolarizing Agents; D009388:Neostigmine; D004491:Edrophonium; D000077123:Rocuronium