Measles, mumps, and rubella antibodies in children 5-6 years after immunization: effect of vaccine type and age at vaccination.
The levels of antibody against measles, mumps, and rubella were determined at 5-6 years postimmunization in 468 children vaccinated with two different trivalent vaccines. The proportions of children without detectable antibody levels were 12 and 3.6% for measles (p < 0.001), 14.9 and 7% for mumps (p = 0.006), and 3.3 and 3.1% for rubella (p = 0.88), respectively, in MMR II and Trivirix recipients. A higher proportion of those vaccinated at younger ages had undetectable or low levels of measles antibody. These data indicate that a large proportion of children vaccinated under routine conditions do not have detectable measles and mumps antibody.
Boulianne
N
N
Centre de Santé Publique de Québec, Beauport, Canada.
De Serres
G
G
Ratnam
S
S
Ward
B J
BJ
Joly
J R
JR
Duval
B
B
D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008458:Measles Vaccine / Q000276:immunology / Q000627:therapeutic use*; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000276:immunology / Q000627:therapeutic use*; D012411:Rubella Vaccine / Q000276:immunology / Q000627:therapeutic use*; D013997:Time Factors; D014611:Vaccination; D017778:Vaccines, Combined / Q000276:immunology / Q000627:therapeutic use
D000914:Antibodies, Viral; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined; C040901:rubella antibodies