Number of platelet dense granules varies with age, schizophrenia and dementia.
In the present study we observed that the number of dense granules per platelet increases with age, attaining a maximum level above the age of about 40 years. Platelets of newborns apparently contain only a small number of dense granules per platelet. The numbers of platelet dense granules and platelet cell size in schizophrenic patients increase compared to age-matched healthy controls. In contrast, in Alzheimer-type dementia the number of platelet dense granules tends to decrease compared to healthy persons.
Kessler
A
A
Department of Membrane Research, Weizman Institute of Science, Rehovot, Israel.
Shinitzky
M
M
Kessler
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000544:Alzheimer Disease / Q000097:blood; D001792:Blood Platelets / Q000648:ultrastructure*; D048429:Cell Size; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood*