Reliability of sequential naloxone challenge tests.
To determine the reliability of serial naloxone challenges, five heroin addicts stabilized on methadone were given 0.2 mg naloxone intravenously on three consecutive days. Two-factor ANOVA revealed that the between-subjects effect accounted for at least 63% of the variance in each of the dependent measures, and the effect of challenge number for at most 22%. Withdrawal tended to be slightly more severe for the first challenge. Intraclass correlation coefficients were calculated for the area-under-the-curve of the change from baseline: subject-rated (.74) and observer-rated (.71) withdrawal, pulse (.88), systolic blood pressure (.58), diastolic blood pressure (.85), and skin temperature (.63).
Rosen
M I
MI
Connecticut Mental Health Center, New Haven 06508, USA.
McMahon
T J
TJ
Margolin
A
A
Gill
T S
TS
Woods
S W
SW
Pearsall
H R
HR
Kreek
M J
MJ
Kosten
T R
TR
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000008:administration & dosage; D009294:Narcotics; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D019966:Substance-Related Disorders / Q000188:drug therapy
D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D008691:Methadone