The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins.
Leukocyte adhesion involves the leukocyte-specific integrins CD11a/CD18, CD11b/CD18 and CD11c/CD18, which bind to intercellular adhesion molecules (ICAM). Three ICAM have been described, and are expressed on leukocytes and various other cells, but are absent from red cells. Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycoprotein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology.
Bailly
P
P
INSERM U76, Institut National de Transfusion Sanguine, Paris, France.
Tontti
E
E
Hermand
P
P
Cartron
J P
JP
Gahmberg
C G
CG
D001789:Blood Group Antigens / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D018845:CD11 Antigens / Q000097:blood*; D018821:CD18 Antigens / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D011485:Protein Binding
D001789:Blood Group Antigens; D018845:CD11 Antigens; D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; C095100:ICAM4 protein, human; D016023:Integrins