title: Topographical regulation of cone and rod opsin genes: parallel, position dependent levels of transcription.
abstract: RNase protection assays were used to follow rhodopsin and red cone opsin mRNA levels during bovine fetal development as a function of retinal position. Following induction, an equivalent radial gradient of rod and cone opsin mRNA is present in the fetal retina. This gradient is maintained in the adult retina even though no corresponding gradient in rod or cone cell density is present. Since the mRNA expression gradient does not progress radially, position dependent levels of photoreceptor-specific transcription is suggested.
authors.affiliation: Department of Molecular Genetics, University of Florida, Gainesville 32610, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: van Ginkel
authors.forename: A M
authors.initials: AM
authors.lastname: Timmers
authors.forename: A
authors.initials: A
authors.lastname: Szél
authors.forename: W W
authors.initials: WW
authors.lastname: Hauswirth
mesh_terms: D000818:Animals; D002417:Cattle; D002452:Cell Count; D005314:Embryonic and Fetal Development / Q000235:genetics; D010786:Photoreceptor Cells / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D012243:Rhodopsin / Q000235:genetics*; D012260:Ribonucleases; D017299:Rod Opsins / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D017299:Rod Opsins; D012243:Rhodopsin; D012260:Ribonucleases