title: Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.
abstract: We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.
authors.affiliation: Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA.
authors.forename: L
authors.initials: L
authors.lastname: Handelsman
authors.forename: L
authors.initials: L
authors.lastname: Limpitlaw
authors.forename: D
authors.initials: D
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Schmeidler
authors.forename: P
authors.initials: P
authors.lastname: Paris
authors.forename: B
authors.initials: B
authors.lastname: Stimmel
mesh_terms: D000328:Adult; D000547:Amantadine / Q000008:administration & dosage* / Q000009:adverse effects; D003042:Cocaine / Q000009:adverse effects; D018491:Dopamine Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006556:Heroin Dependence / Q000523:psychology / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000523:psychology / Q000534:rehabilitation*; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
chemical_list: D018491:Dopamine Agonists; D000547:Amantadine; D003042:Cocaine; D008691:Methadone