title: [Hair-like hyperkeratoses in patients with kidney transplants. A new cyclosporin side-effect].
abstract: We report a 31-year-old renal transplant patient treated with cyclosporin A who developed an unusual sebaceous gland hyperplasia accompanied by a disseminated follicular spiny hyperkeratosis. Those alterations were most evident on his face and limbs. In some locations hairy hyperkeratosis with authentic hair neogenesis was found. The histology of these alterations showed a marked hyperkeratosis of the hair follicles with formation of hair-like spikes either alone or in connection with hairs. The presence of true hairs distinguishes our case from the morphologically similar disseminated spiked hyperkeratosis and other spiny keratinization disorders. Scanning electron microscopy helped to demonstrate the hair-like structure of these keratoses. Some of the sebaceous glands showed cystic widening of their lumina, which were filled with abundant amorphous eosinophilic material, a finding similar to earlier observations. Our case demonstrates that these skin alterations should be classified as side effects of cyclosporin A and that they are apparently dose-dependent.
authors.affiliation: Dermatologische Universitätsklinik, Universität Basel.
authors.forename: J
authors.initials: J
authors.lastname: Izakovic
authors.forename: S A
authors.initials: SA
authors.lastname: Büchner
authors.forename: M
authors.initials: M
authors.lastname: Düggelin
authors.forename: R
authors.initials: R
authors.lastname: Guggenheim
authors.forename: P H
authors.initials: PH
authors.lastname: Itin
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D007644:Darier Disease; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006197:Hair / Q000473:pathology; D006201:Hair Diseases / Q000139:chemically induced* / Q000175:diagnosis; D018859:Hair Follicle / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007642:Keratosis / Q000139:chemically induced* / Q000175:diagnosis; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008855:Microscopy, Electron, Scanning; D011183:Postoperative Complications / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine
vernacular_title: Haarartige Hyperkeratosen bei einem Nierentransplantierten. Eine neue Cyclosporin-Nebenwirkung.