title: The African swine fever virus IAP homolog is a late structural polypeptide.
abstract: The analysis of the complete nucleotide sequence of the African swine fever virus genome has revealed the existence of a number of genes potentially capable of modifying the host's response to the virus infection. In this report, we describe the results of the characterization of the A224L gene that encodes a novel member of the family of apoptosis inhibitors known as IAP proteins. A224L is expressed during the late phase of the infectious cycle, and its polypeptide product is assembled into virus particles.
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, Madrid, Spain.
authors.forename: M R
authors.initials: MR
authors.lastname: Chacón
authors.forename: F
authors.initials: F
authors.lastname: Almazán
authors.forename: M L
authors.initials: ML
authors.lastname: Nogal
authors.forename: E
authors.initials: E
authors.lastname: Viñuela
authors.forename: J F
authors.initials: JF
authors.lastname: Rodríguez
mesh_terms: D000358:African Swine Fever Virus / Q000737:chemistry* / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002461:Cell Line, Transformed; D002522:Chlorocebus aethiops; D004279:DNA, Viral; D051034:Inhibitor of Apoptosis Proteins; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014709:Vero Cells; D014764:Viral Proteins / Q000737:chemistry; D015678:Viral Structural Proteins / Q000737:chemistry* / Q000235:genetics
chemical_list: C097626:A224L protein, African swine fever virus; D004279:DNA, Viral; D051034:Inhibitor of Apoptosis Proteins; D012367:RNA, Viral; D014764:Viral Proteins; D015678:Viral Structural Proteins; C086430:inhibitor of apoptosis, Nucleopolyhedrovirus