title: Reliability of sequential naloxone challenge tests.
abstract: To determine the reliability of serial naloxone challenges, five heroin addicts stabilized on methadone were given 0.2 mg naloxone intravenously on three consecutive days. Two-factor ANOVA revealed that the between-subjects effect accounted for at least 63% of the variance in each of the dependent measures, and the effect of challenge number for at most 22%. Withdrawal tended to be slightly more severe for the first challenge. Intraclass correlation coefficients were calculated for the area-under-the-curve of the change from baseline: subject-rated (.74) and observer-rated (.71) withdrawal, pulse (.88), systolic blood pressure (.58), diastolic blood pressure (.85), and skin temperature (.63).
authors.affiliation: Connecticut Mental Health Center, New Haven 06508, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Rosen
authors.forename: T J
authors.initials: TJ
authors.lastname: McMahon
authors.forename: A
authors.initials: A
authors.lastname: Margolin
authors.forename: T S
authors.initials: TS
authors.lastname: Gill
authors.forename: S W
authors.initials: SW
authors.lastname: Woods
authors.forename: H R
authors.initials: HR
authors.lastname: Pearsall
authors.forename: M J
authors.initials: MJ
authors.lastname: Kreek
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000008:administration & dosage; D009294:Narcotics; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D019966:Substance-Related Disorders / Q000188:drug therapy
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D008691:Methadone