title: A case of angiocentric T-cell lymphoma presenting as lethal midline granuloma.
abstract: A case of angiocentric T-cell lymphoma with glabellar skin being the only affected site was reported. A 43-year-old woman had a several months' history of glabellar swelling followed by progressive and destructive ulceration of the region. Histopathology of the biopsied specimen showed panniculitis with atypical lymphocytes and degenerative vessels filled with atypical cells. Most of the infiltrated lymphocytes were positive for CD2, CD3, CD4 and CD5. Antibodies to Epstein-Barr virus were detected in the patient serum. Intensive chemotherapy using a protocol of the L17M regimen was partially effective for clinical manifestations. Angiocentric T-cell lymphoma presenting as lethal midline granuloma is a rare but distinct entity with an acute fatal course.
authors.affiliation: Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Unno
authors.forename: H
authors.initials: H
authors.lastname: Yaguchi
authors.forename: C
authors.initials: C
authors.lastname: Nishikawa
authors.forename: R
authors.initials: R
authors.lastname: Tsuboi
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006103:Granuloma, Lethal Midline / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000473:pathology*; D009668:Nose Diseases / Q000473:pathology*; D009669:Nose Neoplasms / Q000188:drug therapy / Q000473:pathology*; D015434:Panniculitis / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D012883:Skin Ulcer / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000914:Antibodies, Viral