title: Effects of high-calorie diet on blood pressure and sodium retention in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats.
abstract: Previous reports from our laboratory have documented that spontaneously hypertensive rats (SHR) have insulin resistance and that insulin resistance is enhanced by high-caloric diet (HCD) feeding. The aim of this study was to elucidate the effect of HCD on blood pressure and sodium retention in both SHR and normotensive Wistar-Kyoto rats (WKY). SHR and WKY were divided into two groups. One group of rats was fed normal diet (ND). The other rats were fed HCD. After the 8-week feeding period, insulin suppression tests were performed. The animals were individually housed in metabolic cages for the last 2 days of the experiment. Food consumption was recorded for 24 h, and a 24-h urine was collected to calculate the sodium excretory ratio. In both strains, body weight was significantly increased by HCD feeding. Blood pressure was significantly elevated in SHR by HCD feeding, whereas that of WKY was not affected by HCD feeding. In both strains, steady-state plasma glucose (SSPG) during the insulin suppression test was higher in the HCD group than in the ND group. SSPG was consistently higher in SHR than in WKY treated with HCD. Urinary sodium excretion ratio was significantly decreased in SHR by HCD, and plasma potassium concentrations were significantly lower in SHR with HCD than in SHR with ND, whereas those of WKY were not affected by HCD feeding. SHR are more sensitive to the induction of insulin resistance than WKY, resulting in sodium retention and elevation of blood pressure.
authors.affiliation: Department of Internal Medicine, Shimane Medical University, Izumo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Nara
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Yamori
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D001835:Body Weight; D002149:Energy Intake; D005951:Glucose Tolerance Test; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D012982:Sodium, Dietary
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012982:Sodium, Dietary; D012964:Sodium