title: Functional and genetic analysis of annexin VI.
abstract: This study is concerned with the determination of the function of the 68kDa calcium-binding protein, annexin VI. Studies on the structure and regulation of the gene include a detailed analysis of annexin VI expressed heterologously in human A431 carcinoma cells. We have recently discovered that annexin VI is subject to a novel growth dependent post-translational modification. Interestingly, the protein exerts a negative effect on A431 cells. This effect was manifested as a partial reversal of the transformed phenotype. We are currently exploring the hypothesis that the post-translational modification of annexin VI is required for sub-cellular targeting, and that correct localisation within the cell is essential for function.
authors.affiliation: Department of Physiology, University College London, UK.
authors.forename: H C
authors.initials: HC
authors.lastname: Edwards
authors.forename: S E
authors.initials: SE
authors.lastname: Moss
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D017317:Annexin A6 / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D005796:Genes; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D012091:Repetitive Sequences, Nucleic Acid; D014018:Tissue Distribution
chemical_list: D017317:Annexin A6