IL-10 immunosuppression in transplantation.
The description of IL-10 as an immunosuppressive cytokine that inhibits numerous T-cell and antigen-presenting cell functions has led to the investigation of the role of IL-10 in graft acceptance and rejection, in both manipulated and unmanipulated experimental systems. Recent results suggest a complex interaction of IL-10 with other cytokines and numerous cell types. Although IL-10 is not a simple immunosuppressive molecule, manipulation of its actions may be a useful approach for prolonging graft survival and preventing rejection.
Bromberg
J S
JS
University of Michigan, Ann Arbor, USA.
D000818:Animals; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D016753:Interleukin-10 / Q000276:immunology*; D016377:Organ Transplantation
D016753:Interleukin-10