title: [Pulmonary metastases of glioblastoma].
abstract: Extracranial metastases arising from primary brain tumors are very unusual. We report a case of glioblastoma with intra-thoracic spread characterized by mediastinal lymph nodes metastasis and bronchial, lung parenchyma and pleura carcinomatous lymphangitis. Pathologic findings are consistent with non-differentiated cell proliferation but Glial Fibrillary Acidic Protein immunodetection can be helpful to relate such a non-differentiated cell proliferation to its glial origin. The mechanisms of extra-cerebral spread are discussed according to autopsic findings and to the data reported in the literature.
authors.affiliation: Unité de pneumologie, Hôpital Henri-Mondor, Créteil.
authors.forename: O
authors.initials: O
authors.lastname: Granjon
authors.forename: F
authors.initials: F
authors.lastname: Lange
authors.forename: F J
authors.initials: FJ
authors.lastname: Authier
authors.forename: F
authors.initials: F
authors.lastname: Lebargy
mesh_terms: D001344:Autopsy; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology; D005909:Glioblastoma / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology
vernacular_title: Métastases pulmonaires d'un glioblastome.