Clinical, hormonal and sonographic predictors of successful RU-486-induced abortions.
To evaluate which method, clinical, hormonal or sonographic, can be used as the best predictor of successful RU-486-induced abortions, 20 healthy women with fetal cardiac activity, between 6 and 9 weeks from the last menstrual period and desiring abortion, were studied. Fourteen women (70%) successfully aborted, and 6 (30%) failed to abort within 7 days following therapy. A small hematoma, seen as a localized detachment of the gestational sac, was observed in the decidua capsularis in women who aborted successfully. A significant decrease in plasma levels of estradiol and progesterone (p < 0.04) and significantly increased cortisol levels (p < 0.001) in the plasma of the 14 patients who aborted were noted by the 7th day following treatment. No significant changes were observed in the 6 nonaborting patients. In conclusion, the differences in the early sonographic findings may be helpful in the early prediction of successful RU-486 administration.
Menashe
Y
Y
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Bider
D
D
Shalev
J
J
Pariente
C
C
Serr
D M
DM
D000019:Abortifacient Agents; D000028:Abortion, Induced; D006063:Chorionic Gonadotropin / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015735:Mifepristone; D011237:Predictive Value of Tests; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging*
D000019:Abortifacient Agents; D006063:Chorionic Gonadotropin; D006454:Hemoglobins; D015735:Mifepristone; D011374:Progesterone; D004958:Estradiol; D006854:Hydrocortisone