[Pulmonary metastases of glioblastoma].
Extracranial metastases arising from primary brain tumors are very unusual. We report a case of glioblastoma with intra-thoracic spread characterized by mediastinal lymph nodes metastasis and bronchial, lung parenchyma and pleura carcinomatous lymphangitis. Pathologic findings are consistent with non-differentiated cell proliferation but Glial Fibrillary Acidic Protein immunodetection can be helpful to relate such a non-differentiated cell proliferation to its glial origin. The mechanisms of extra-cerebral spread are discussed according to autopsic findings and to the data reported in the literature.
Granjon
O
O
Unité de pneumologie, Hôpital Henri-Mondor, Créteil.
Lange
F
F
Authier
F J
FJ
Lebargy
F
F
D001344:Autopsy; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology; D005909:Glioblastoma / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology
Métastases pulmonaires d'un glioblastome.