A comparative study of the visible light photochemistry of gilvocarcins V and M.
Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturated dry DMSO was also determined. These values are not different, within experimental error, from those corresponding to gilvocarcin V (GV). Because GV is a strong photocytotoxic agent and GM is not, these results imply that Type I and Type II mechanisms are not important pathways in the cytotoxicity of GV.
Alegría
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AE
Department of Chemistry, CUH Station, University of Puerto Rico at Humacao.
Zayas
L
L
Guevara
N
N
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000528:radiation effects*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000528:radiation effects*; D003374:Coumarins; D006027:Glycosides; D008027:Light; D010777:Photochemistry
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003374:Coumarins; D006027:Glycosides; C031782:gilvocarcin M; C031781:gilvocarcin V