[Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist].
A platelet-activating factor (PAF) antagonist was found to inhibit superoxide production in the leukocytes of patients with type IIA hypercholesterolemia. PAF (10(-7)-10(-6) M) alone failed to stimulate superoxide production in intact or PAF-antagonist-treated leukocytes. The PAF-antagonist-induced inhibition of superoxide production was observed in the leukocytes from hypercholesterolemic patients whose plasma cholesterol levels varied from 8.3 to 14.0 mmole/l.
Muzia
G I
GI
Bol'shakova
N S
NS
Cherniad'eva
I F
IF
Kukharchuk
V V
VV
Kulikov
V I
VI
D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D013481:Superoxides / Q000037:antagonists & inhibitors*
D010713:Phosphatidylcholines; D010972:Platelet Activating Factor; D013481:Superoxides
Ingibirovanie obrazovaniia superoksidnykh radikalov leĭkotsitami krovibol'nykh s giperkholesterinemieĭ pod vliianiem lipidnogo antagonista faktora aktivatsii trombotsitov.