Sex-related differences in acetazolamide-induced cerebral vasomotor reactivity.
OBJECTIVE
Cerebral vasomotor reactivity can easily be assessed reliably by measuring vasodilatory response to acetazolamide by transcranial Doppler sonography. The aim of this study was to confirm the hypothesis that female sex is associated with an increased cerebrovascular flow reserve.


METHODS
Blood flow velocity of the middle cerebral artery was measured by transcranial Doppler sonography in 36 healthy sex- and age-matched subjects. After the initial blood flow velocities were recorded, the subjects received 14.3 mg/kg body wt acetazolamide, ie, 1 g/70 kg, intravenously. The measurements were repeatedly performed at 5-minute intervals starting 10 minutes after injection and lasting for 30 minutes. The highest measured flow velocities were used for further analysis.


RESULTS
In both groups mean blood flow velocity increased significantly after acetazolamide (women, from 60.2 +/- 12.5 to 89.9 +/- 14.4 cm/s, P < .006; men, from 54.5 +/- 18.8 to 75.7 +/- 24.5 cm/s, P < .02). The difference in mean blood flow velocity after acetazolamide between groups of women and men was statistically significant (P < .02).


CONCLUSIONS
Female subjects show an increased vasodilatory response to the acetazolamide test compared with men.
Karnik
R
R
Second Department of Medicine, Krankenanstalt Rudolfstiftung, Vienna, Austria.
Valentin
A
A
Winkler
W B
WB
Khaffaf
N
N
Donath
P
P
Slany
J
J
D000054:Acceleration; D000086:Acetazolamide / Q000008:administration & dosage / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure; D001835:Body Weight; D016022:Case-Control Studies; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D012727:Sex Characteristics; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014666:Vasomotor System / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology
D014665:Vasodilator Agents; D000086:Acetazolamide