[Effect of praziquantel treatment on serum circulating soluble egg antigen-antibody complex (SEAIC) level in mice infected with Schistosoma japonicum].
Employing Capture ELISA, we determined the level of the circulating soluble egg antigen-antibody complex (SEAIC) in sera from mice infected with Schistosoma japonicum for 7 weeks and then treated the infected mice with praziquantel (100 mg/kg body weight). It was noted that the serum SEAIC level in treated mice dropped gradually after treatment. There was a significant decrease in 13 out of 15 mice in serum SEAIC levels at five weeks after treatment, OD value dropped from 0.358 +/- 0.074 to 0.165 +/- 0.049 (P < 0.01). The serum SEAIC level in 10 mice declined to disappear (OD < 0.097) by the 7th week after treatment. By contrast, no significant changes in serum SEAIC levels were found in the non-treated mice, the serum SEAIC level in the control group maintained moderately high (OD = 0.266 +/- 0.076) till the end of the observation.
Shi
G
G
Division of Clinical Science, Huashan Hospital, Shanghai Medical University.
Xu
Z
Z
Fu
C
C
Weng
X
X
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood*; D005260:Female; D051379:Mice; D010063:Ovum / Q000276:immunology; D011223:Praziquantel / Q000627:therapeutic use*; D012554:Schistosomiasis japonica / Q000188:drug therapy / Q000276:immunology*; D012556:Schistosomicides / Q000627:therapeutic use*
D000936:Antigen-Antibody Complex; D012556:Schistosomicides; D011223:Praziquantel