[Analysis of cytogenetic activity of food dyes].
The cytogenetic activity of food dyes was examined in the experiments on male C57B1/6 mice which were orally given during 5 days the following daily doses: Tartrasine (E102), 0.5 and 5.0 mg/kg; Indigo carmine (E132), 1.4 and 14 mg/kg; Canset yellow (E110), 0.17 and 1.7 mg/kg; Cochenillerot A (E124), 0.63 and 6.3mg/kg; Azorubin (E122), 1 and 10 mg/kg and Patentblau V (E131), 0.08 and 0.8 mg/kg. Five hundred metaphase slides each were analyzed in the control and experimental test series. The findings may conclude that the dyes tested within the above dose ranges do not induce any increase in the level of cells with chromosomal damages in the inbred animals.
Durnev
A D
AD
Oreshchenko
A V
AV
Kulakova
A V
AV
Beresten'
N F
NF
D000818:Animals; D002869:Chromosome Aberrations; D005505:Food Coloring Agents / Q000633:toxicity*; D008297:Male; D008677:Metaphase; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests
D005505:Food Coloring Agents
Analiz tsitogeneticheskoĭ aktivnosti pishchevykh krasitele'i.