Effects of moderate chronic alcoholism treatment on fertilization.
The effect of 10% m/v ethanol treatment during 4 weeks on mice reproductive function was studied. Fertilization rates significantly decreased when oocytes came from alcoholic females. Oocytes viability were decreased since fragmented ova were increased. Also decreased number of oocytes per oviduct was found. Spontaneous activation was increased in alcoholic females. Motility and hyperactivation were not been altered by treatment. These results show that the female gamete seem to be more sensible to moderate chronic alcoholism than the male gamete.
Cebral
E
E
Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina, Buenos Aires, Argentina.
Lasserre
A
A
Vitullo
A
A
Rettori
V
V
de Gimeno
M A
MA
D000437:Alcoholism / Q000150:complications*; D000704:Analysis of Variance; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development
D000431:Ethanol