[Comparison of in-vitro and in-vivo activities of enoxacin and ofloxacin against the Mycobacterium tuberculosis].
Enoxacin (ENX) showed a moderate degree of activities in vitro against Mycobacterium tuberculosis in modified Saunton medium and modified Lowenstein-Jensen Medium with MICs from 1 to 8micrograms/ml. Ofloxacin (OFLX) is superior to ENX, with MICs from 0.5 to 2.0micrograms/ml. In terms of median survival time (ST50), ENX at doses both 3mg (about 150mg/kg) daily and 6mg (about 300mg/kg) intermittently were inactive (P > 0.05) against M. tuberculosis infection in mice. OFLX at the same doses all were very significantly effective (P < 0.01).
Xu
G
G
Beijing Tuberculosis Research Institute.
Li
H
H
Liu
S
S
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015365:Enoxacin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy*
D000995:Antitubercular Agents; D015365:Enoxacin; D015242:Ofloxacin