Inhibition of bacterial growth in vitro by human ejaculate seminal plasma fraction 1 and its possible practical use in male infertility phenomenon.
OBJECTIVE
The in vitro bacteriostatic effect on bacteria by a fraction of human ejaculate (HuSePl-Fr1) was studied.


METHODS
As bacterial indicators, Pseudomonas aeruginosa (Pa), total coliforms (Tc), fecal coliforms (Fc), Escherichia coli (Ec), and Staphylococcus aureus (Sa) were used. These bacterial strains are known as agents that cause urinary and sexually transmitted infections (STI).


RESULTS
Preliminary results suggest that HuSePl-Fr1 has a significant in vitro bacteriostatic effect on Pa and Sa at 42 degrees C. In addition, Pa was inhibited at 37 degrees C after 48 hr incubation. The remaining bacterial indicators were not affected.


CONCLUSIONS
The results indicate a possible protective role of HuSePl-Fr1 in treatment of infertile men due to genital infections.
Marcus
Z H
ZH
Blood Bank, Edith Wolfson Medical Center, Holon, Israel.
Lewin
L M
LM
Ginsberg
R
R
D017077:Culture Media, Conditioned; D004926:Escherichia coli / Q000254:growth & development*; D004927:Escherichia coli Infections / Q000517:prevention & control; D006801:Humans; D066298:In Vitro Techniques; D007248:Infertility, Male / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000254:growth & development*; D012661:Semen / Q000502:physiology*; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000254:growth & development*
D017077:Culture Media, Conditioned