[Ratio of neuromediator amino acids in a comparative analysis of the stress protective effects of delta-sleep inducing peptide and piracetam].
The GABAergic system was adequate altered after simultaneous use of delta-sleeping peptide and piracetam in intact animals: gamma-butyric acid was accumulated unidirectionally by inhibiting brain glutamate decarboxylase activity. Administration of the peptide caused a slight decrease in the levels of aspartic acid, while piracetam contributed to a marked accumulation of the amino acid. The antistressor and adaptive effects of each drug were augmented if they were given simultaneously before acute emotional stress developed in the animals during one-hour hypokinesia; these effects were expressed as stabilized balance of inhibitory and excitatory neurotransmitter amino acids.
Mendzheritskiĭ
A M
AM
Uskova
N I
NI
Lysenko
A V
AV
Matsionis
A E
AE
Sametskiĭ
E A
EA
D000222:Adaptation, Physiological; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors; D008297:Male; D008854:Microscopy, Electron; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D013312:Stress, Physiological / Q000517:prevention & control*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018696:Neuroprotective Agents; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D003701:Delta Sleep-Inducing Peptide; D005968:Glutamate Decarboxylase; D010889:Piracetam
Sootnoshenie neĭromediatornykh aminokislot pri sravnitel'nom analize stressprotektornykh éffektov delta-sonindutsiruiushchego peptida i piratsetama.