Decreased urinary peptide excretion in schizophrenic patients after neuroleptic treatment.
Six schizophrenic patients had their urinary peptide levels measured before and after 5 weeks of treatment with neuroleptic medications. For two patients, levels were also measured after a reduction in the neuroleptic dose. Because of the heterogeneity of peptide peaks with the same bioactivity, the overall peptide levels were compared to initial levels. A neuroleptic effect on peptide levels was demonstrated. Several research groups have reported enzyme induction caused by neuroleptics in vivo.
Reichelt
K L
KL
Department of Pediatric Research, University of Oslo, Rikshospitalet, Norway.
Teigland-Gjerstad
B
B
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000652:urine*; D012016:Reference Values; D012559:Schizophrenia / Q000188:drug therapy* / Q000652:urine; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D010455:Peptides