title: TUDCA and UDCA are incorporated into hepatocyte membranes: different sites, but similar effects.
abstract: The aim of this paper is to point out that: 1) CDCA and DCA increase the polarity of cell membranes and cause the release of cholesterol and phospholipid from the membranes; 2) the extent of this damage is inversely correlated with the cholesterol content of the membrane investigated; 3) UDCA, TUDCA and GUDCA decrease membrane polarity; 4) they prevent membrane damage when added prior to CDCA or DCA; 5) UDCA appears to be incorporated into the apolar domain of the membrane, TUDCA, GUDCA into the interface; 6) UDCA decreases HLA class I expression on hepatocyte membranes; 7) CDCA induces GLDH-release from liver mitochondria and increases mitochondrial membrane polarity and mobility; and 8) UDCA reduces the release of GLDH from mitochondria caused by CDCA.
authors.affiliation: Department of Gastroenterology, Johann Wolfgang Goethe Universität, Frankfurt am Main, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Leuschner
authors.forename: S
authors.initials: S
authors.lastname: Guldutuna
authors.forename: S
authors.initials: S
authors.lastname: Bhatti
authors.forename: A
authors.initials: A
authors.lastname: Elze
authors.forename: M
authors.initials: M
authors.lastname: Imhof
authors.forename: T
authors.initials: T
authors.lastname: You
authors.forename: G
authors.initials: G
authors.lastname: Zimmer
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003840:Deoxycholic Acid / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000276:immunology / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D013655:Taurochenodeoxycholic Acid / Q000378:metabolism*; D014580:Ursodeoxycholic Acid / Q000378:metabolism*
chemical_list: D015395:Histocompatibility Antigens Class I; D008563:Membrane Lipids; D010743:Phospholipids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine; D014580:Ursodeoxycholic Acid; D002784:Cholesterol