title: [Effect of primary prevention of Pneumocystis carinii pneumonia on the inaugural clinical and biological presentation of AIDS: 624 cases (Aquitaine Cohort, 1985-1994)].
abstract: In a cohort of HIV-infected patients, this study compares the clinical and immunological features at the time of AIDS diagnosis of patients who either received primary Pneumocystis carinii prophylaxis (P+; n = 335) or who did not (P-; n = 289). Frequency of P carinii pneumonia was lower in P+ than in P- patients (14.9% vs 26.0%; p < 0.001). Conversely, toxoplasmic encephalitis, esophageal candidiasis, cytomegalovirus disease and M avium complex disease were more frequent in P+ patients. CD4+ count (median/mm3) at the time of AIDS diagnosis was lower in P+ than in P- patients: 22 vs 97 (p < 0.001); this suggests that early intervention delays the onset of AIDS for about one year. While searching for new prevention strategies against other opportunistic infections, efforts should be expanded to improve prophylaxis of P carinii pneumonia which remains in France the most frequent first AIDS-related illness.
authors.affiliation: Service de médecine interne, hôpital Saint-André, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Morlat
authors.forename: J B
authors.initials: JB
authors.lastname: Hubert
authors.forename: G
authors.initials: G
authors.lastname: Chêne
authors.forename: M
authors.initials: M
authors.lastname: Buisson
authors.forename: M C
authors.initials: MC
authors.lastname: Paty
authors.forename: C
authors.initials: C
authors.lastname: Lasseur
authors.forename: J
authors.initials: J
authors.lastname: Constans
authors.forename: N
authors.initials: N
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Beylot
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000517:prevention & control*; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D015497:HIV-1; D006785:Hospitals, University; D006801:Humans; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology / Q000517:prevention & control*
vernacular_title: Effet de la prophylaxie primaire de la pneumocystose pulmonaire sur la présentation clinique et biologique inaugurale du SIDA: 624 observations (cohorte Aquitaine, 1985-1994). d'épidémiologie clinique du SIDA en Aquitaine (GECSA).