A new antiherpetic agent produced by Streptomyces sp. strain no. 758.
A new antiherpetic agent, AH-758, was isolated from the culture broth of Streptomyces sp. strain No. 758. The structure was determined by NMR special analyses to be a new antibiotic belonging to bafilomycin group containing (5-oxo-2-pyrrolin-2-yl) methyl fumarate in its C-21.
Uyeda
M
M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Kondo
K I
KI
Ito
A
A
Yokomizo
K
K
Kido
Y
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017077:Culture Media, Conditioned; D006094:Gram-Positive Bacteria / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
C097817:AH 758; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D017077:Culture Media, Conditioned; D018942:Macrolides