title: Comparison of gadolinium-DTPA and polylysine-gadolinium-DTPA--enhanced magnetic resonance imaging of hepatocarcinoma in the rat.
abstract: OBJECTIVE
  To compare the magnetic resonance (MR) imaging characteristics of gadolinium-DTPA (Gd-DTPA), a low-molecular-weight contrast agent, and polylysine-Gd-DTPA, a macromolecular contrast agent, in two types of hepatocarcinomas (HCC) in the rat.
  
  
  METHODS
  T1-weighted spin-echo images were obtained in 13 rats with chemically induced HCC and 26 rats with Novikoff HCC before and 3 minutes to 60 hours after administration of either Gd-DTPA or polylysine-Gd-DTPA.
  
  
  RESULTS
  Three minutes after polylysine-Gd-DTPA administration, the tumor-to-liver contrast of the two types of HCC increased significantly (positive contrast for chemically induced HCC and negative contrast for Novikoff HCC). At 30 minutes and 60 hours, the tumor-to-liver contrast remained above baseline values in chemically induced HCC and returned progressively to baseline values in Novikoff HCC. No significant increase in tumor-to-liver contrast was observed after Gd-DTPA administration.
  
  
  CONCLUSIONS
  These results suggest that polylysine-Gd-DTPA provides a higher and more prolonged increase in tumor-to-liver contrast than Gd-DTPA.
authors.affiliation: Department of Radiology, Cliniques Universitaires St-Luc, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Grandin
authors.forename: B E
authors.initials: BE
authors.lastname: Van Beers
authors.forename: R
authors.initials: R
authors.lastname: Demeure
authors.forename: J F
authors.initials: JF
authors.lastname: Goudemant
authors.forename: I
authors.initials: I
authors.lastname: Mottet
authors.forename: J
authors.initials: J
authors.lastname: Pringot
mesh_terms: D000792:Angiography; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D007089:Image Enhancement; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D046911:Macromolecular Substances; D008279:Magnetic Resonance Imaging; D008297:Male; D008970:Molecular Weight; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011107:Polylysine / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D003287:Contrast Media; D046911:Macromolecular Substances; D009942:Organometallic Compounds; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA