Gamma delta T lymphocytes in mumps meningitis patients.
Flowcytometric analysis on T-cell subpopulations in the blood and cerebrospinal fluid (CSF) of 10 children with mumps meningitis (MM) revealed that the proportion of lymphocytes which bore the gamma delta T-cell receptor for antigen was significantly higher in CSF than in autologous and heterologous blood samples. gamma delta T-cell values in CSF of MM patients were also significantly higher than those calculated in CSF specimens from nine children with non-inflammatory neurological disorders. Whether and how the expanded CSF gamma delta T-lymphocyte subset, either CD8+ or double-negative (CD4-/CD8-), contributes to the eradication of mumps virus infection from the central nervous system represents a central focus of our ongoing research.
Bertotto
A
A
Department of Paediatrics, Perugia University Medical School, Italy.
Spinozzi
F
F
Gerli
R
R
Bassotti
G
G
Forenza
N
N
Pazzelli
P
P
Bartolucci
M
M
De Giorgi
G
G
Vaccaro
R
R
D015703:Antigens, CD; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008581:Meningitis / Q000097:blood* / Q000134:cerebrospinal fluid*; D009107:Mumps / Q000097:blood* / Q000134:cerebrospinal fluid*; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes
D015703:Antigens, CD; D011948:Receptors, Antigen, T-Cell