Experimental incomplete spinal cord injury: treatment with a combination of nimodipine and adrenaline.
The effect of combination of nimodopine and adrenaline treatment on the motility deficits following secondary spinal cord damage was studied. Morphometric axonal analyses were also done. Incomplete spinal compression was induced in albino New Zealand rabbits anesthetized with ketamine. Neurological deficit was assessed by Tarlov's scale. The animals were divided into different groups. In one group the animals were anesthetized and subjected to all procedures except spinal cord injury and pharmacological treatment. Each of the other groups were divided into 2 subgroups; the spinal cord compression was induced for 2 min in one subgroup and 5 min in other subgroup. The pharmacological treatment in different groups consisted of slow intravenous infusions of saline alone, combination of adrenaline and nimodipine, nimodipine alone and adrenaline alone. The evolution of the motor damage was evaluated by comparing scores obtained with Tarlov's scale 1, 24 and 48 hrs after the end of spinal cord compression. In all animals, spinal cord compression for 2 and 5 min induced a 5th degree motor deficit. Treatment with saline improved slightly the motor deficit. The improvement of motor deficit was much better when a combination of nimodipine and adrenaline was used. The animals treated with nimodipine alone showed a better recovery in comparison with the animals treated with saline alone.
Gambardella
G
G
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.
Collufio
D
D
Caruso
G N
GN
Abbate
F
F
Germanà
G
G
Tomasello
F
F
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000627:therapeutic use*; D005260:Female; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D011817:Rabbits; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D009553:Nimodipine; D004837:Epinephrine