Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents.
Two flavivirus-like viruses, GB virus-A (GBV-A) and GB virus-B (GBV-B), were recently identified in the GB hepatitis agent, and are distinct from the hepatitis A to E viruses. The putative helicase domain of GBV-A and GBV-B was found to have amino acid sequence homology with hepatitis C virus (HCV), and distantly, is also related to pestiviruses, flaviviruses, and plant viruses. A phylogenetic tree construction showed that GBVs and HCV are closely related, and they are clustered with pestiviruses, flaviviruses and plant viruses in that order.
Ohba
K
K
Second Department of Medicine, Nagoya City University Medical School, Japan.
Mizokami
M
M
Lau
J Y
JY
Orito
E
E
Ikeo
K
K
Gojobori
T
T
D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D005416:Flavivirus / Q000502:physiology*; D016174:Hepacivirus / Q000502:physiology; D008969:Molecular Sequence Data; D009029:Mosaic Viruses / Q000502:physiology*; D010576:Pestivirus / Q000502:physiology*; D010802:Phylogeny; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software
D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases