title: Clozapine-caused eosinophilic colitis.
abstract: Four patients with diarrhea and eosinophilia associated with clozapine therapy are presented. In two cases clozapine therapy was interrupted but then restarted; all patients eventually tolerated clozapine well. A syndrome of clozapine-induced eosinophilic colitis is suggested.
authors.affiliation: McLean Hospital, Belmont, Massachusetts 02178, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Friedberg
authors.forename: F R
authors.initials: FR
authors.lastname: Frankenburg
authors.forename: J
authors.initials: J
authors.lastname: Burk
authors.forename: W
authors.initials: W
authors.lastname: Johnson
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003092:Colitis / Q000150:complications* / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine