title: Mineral bioavailability and bone mineral contents in pigs given calcium carbonate postprandially.
abstract: We have further investigated the "meal effect" on mineral bioavailability in pigs by mineral balance studies and measurements of bone ash contents and bending moment. A group of seven pigs (CAA) was given all its dietary Ca as CaCO3 5 h after the first daily meal for 8 weeks. The control group of seven pigs received CaCO3 in the meal. Both groups were given normal P within the meals. Ca and P absorption and retention were evaluated by a 10-day balance trial. Several bones were collected at slaughter to determine bone ash, Ca, and P contents and bending moment (three-point bending test). Ingesting Ca after the meal did not affect Ca bioavailability or phosphorus absorption, but did reduce P retention, which in turn decreased the bone scores. Osteopenia, indicated by decreased total mineral contents of bones (and decreased ash:bone volume ratio), was associated with elevated plasma osteocalcin in the CAA group. Thus, CaCO3 need not be incorporated into a meal for high Ca absorption, provided that Ca is given after a meal, but simultaneous intakes of Ca and P are required for the best mineral retention.
authors.affiliation: Laboratoire de Nutrition et Sécurité Alimentaire, INRA, Jouy-en-Josas, France.
authors.forename: A
authors.initials: A
authors.lastname: Pointillart
authors.forename: C
authors.initials: C
authors.lastname: Colin
authors.forename: H C
authors.initials: HC
authors.lastname: Lacroix
authors.forename: L
authors.initials: L
authors.lastname: Guéguen
mesh_terms: D000042:Absorption; D000469:Alkaline Phosphatase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001682:Biological Availability; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015592:Immunoradiometric Assay; D008297:Male; D015675:Osteocalcin / Q000097:blood; D016226:Phosphorus, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013552:Swine; D013977:Tibia / Q000502:physiology
chemical_list: D002136:Calcium, Dietary; D016226:Phosphorus, Dietary; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002119:Calcium Carbonate