[The biomimetic oxidation of propiverine hydrochloride and 1-methyl-4-piperidylbenzilate].
The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/pyridine/hydrogen peroxide affords unchanged 1 and 2 and 15 potential metabolites, which were isolated and identified. These compounds are products of cleavage of the ester bond, of O-dealkylation, aromatic oxidation, respectively of decarboxylation, demethylation, and N-oxidation, Products were identified by TLC, UV, and MS in comparison with authentic samples. Thereby we found a nearly conformity with rat metabolism.
Fröhlich
L
L
Institut für Pharmazie der Humboldt-Universität zu Berlin.
Pietzyk
B
B
Göber
B
B
D000818:Animals; D001561:Benzilates / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010880:Piperidines / Q000737:chemistry*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D001561:Benzilates; D010880:Piperidines; C015586:propiverine; C020407:enpiperate
Untersuchungen zur biomimetischen Oxidation von Propiverin-hydrochlorid und 1-Methyl-4-piperidyl benzilat.