Fever and rigors as sole symptoms of azathioprine hypersensitivity.
The case history of a haemodialysis patient with fever and rigors is presented. This diagnostic problem turned out to be a hypersensitivity reaction to azathioprine, with identical complaints recurring after a rechallenge with azathioprine, findings which resolved on discontinuation of this drug. The more extended indications for use of azathioprine warrant attention to the possibility of side-effects like drug fever.
Smak Gregoor
P J
PJ
Department of Internal Medicine and Nephrology, St. Clara Hospital, Rotterdam, Netherlands.
van Saase
J L
JL
Weimar
W
W
Kramer
P
P
D001379:Azathioprine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012768:Shivering
D007166:Immunosuppressive Agents; D001379:Azathioprine