title: Etiology of chronic renal failure in Turkish children.
abstract: The etiology of chronic renal failure (CRF) was studied in 459 Turkish children (205 girls, 254 boys) for the period January 1979-December 1993. Their mean age at onset of CRF was 9.5 +/- 4.2 years (range 1-16 years); CRF was defined as a glomerular filtration rate (GFR) below 50 ml/min per 1.73 m2 for at least 6 months. When a GFR determination was not available, the serum creatinine concentration was used: greater than 1 mg/dl for children aged 1-3 years, greater than 1.5 mg/dl for those 3-10 years and greater than 2 mg/dl for those 10-16 years. Primary renal disorders were as follows: reflux nephropathy 32.4% glomerular diseases 22.2%, hereditary renal disorders 11.4%, amyloidosis 10.6%, urinary stones 8% and other renal disorders 15.4%. Twenty-three cases of reflux nephropathy (15.4%) were associated with neural tube defects (NTD) and 20 (13.4%) were caused by infravesical obstruction. CRF caused vesicoureteral reflux associated with NTD and amyloidosis are more frequent in our series compared with west European and Nordic countries.
authors.affiliation: Department of Pediatric Nephrology, Medical Faculty of Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sirin
authors.forename: S
authors.initials: S
authors.lastname: Emre
authors.forename: H
authors.initials: H
authors.lastname: Alpay
authors.forename: A
authors.initials: A
authors.lastname: Nayir
authors.forename: I
authors.initials: I
authors.lastname: Bilge
authors.forename: F
authors.initials: F
authors.lastname: Tanman
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology