title: The determination of palladium in fosinopril sodium (monopril) by ICP-MS.
abstract: A rapid, sensitive ICP-MS method was developed to determine palladium in fosinopril sodium. The assay could not be carried out in a purely aqueous solvent owing to the instability of the palladium species in this media. It was found that the most appropriate vehicle for solubilization of this material was a solution of 25% (v/v) 2-butoxyethanol and water. A minimum quantifiable limit of 0.1 microns g-1 for Pd in the sample (corresponding to 1 ng Pd mL-1 in the analyte solution) was obtained.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA.
authors.forename: N
authors.initials: N
authors.lastname: Lewen
authors.forename: M
authors.initials: M
authors.lastname: Schenkenberger
authors.forename: T
authors.initials: T
authors.lastname: Larkin
authors.forename: S
authors.initials: S
authors.lastname: Conder
authors.forename: H G
authors.initials: HG
authors.lastname: Brittain
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D004340:Drug Contamination; D017328:Fosinopril / Q000737:chemistry*; D016014:Linear Models; D013058:Mass Spectrometry / Q000379:methods; D010165:Palladium / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D012997:Solvents; D010165:Palladium; D017328:Fosinopril