Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.
On intracerebral infection with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV), certain mouse strains develop a chronic demyelinating disease similar both clinically and pathologically to human multiple sclerosis. Other strains remain resistant. We previously established that differential susceptibility to this demyelinating disease exists among BALB/c substrains, with BALB/cAnNCr mice being susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice are rendered susceptible to TMEV-induced demyelination on exposure to low dose gamma-irradiation before TMEV infection. BALB/cAnNCr and irradiated, infected BALB/cByJ animals are protected against TMEV-induced demyelination by the transfer of a splenic population from TMEV-infected BALB/cByJ donors. Resistance to demyelination appears to be mediated by a CD8+ radiosensitive population, which is induced on infection with TMEV and which must act early to establish resistance to TMEV-induced demyelination.
Nicholson
S M
SM
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611, USA.
Dal Canto
M C
MC
Miller
S D
SD
Melvold
R W
RW
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000528:radiation effects / Q000637:transplantation*; D003711:Demyelinating Diseases / Q000276:immunology / Q000517:prevention & control; D004198:Disease Susceptibility; D004307:Dose-Response Relationship, Radiation; D007108:Immune Tolerance / Q000528:radiation effects; D007113:Immunity, Innate / Q000528:radiation effects; D016219:Immunotherapy, Adoptive; D051379:Mice; D008807:Mice, Inbred BALB C; D011051:Poliomyelitis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D013154:Spleen / Q000637:transplantation; D017945:Theilovirus / Q000276:immunology*