Severe arterial thrombosis in a congenitally factor VII deficient patient.
We report a patient with congenital factor VII deficiency who developed severe arterial thrombosis. A 63-year-old-woman presented low factor VII clotting activity, amidolytic activity and antigen level < 4%. Activated factor VII plasmatic level was < 0.03 ng/ml compared to 4 ng/ml for the control value. She developed severe aorto-iliac thrombosis. 7 d before the thrombotic event, factor VII replacement therapy had been infused. Successful low molecular weight heparin therapy led to total disappearance of the aorto-iliac thrombus without bleeding complications. This suggests that factor VII infusion might have a thrombogenic effect in vivo and might be responsible for thrombosis.
Escoffre
M
M
Service d'Angiohématologie, Hôpital Lariboisière, Paris, France.
zini
J M
JM
Schliamser
L
L
Mazoyer
E
E
Soria
C
C
Tobelem
G
G
Dupuy
E
E
D001018:Aortic Diseases / Q000209:etiology*; D005168:Factor VII Deficiency / Q000150:complications* / Q000151:congenital; D005260:Female; D006801:Humans; D007083:Iliac Artery; D008875:Middle Aged; D013927:Thrombosis / Q000209:etiology*