Schistosoma mansoni in the baboon: modulation of pathology after vaccination with polyclonal anti-idiotypic antibodies.
Vaccination of five baboons with an anti-idiotypic vaccine to irradiated Schistosoma mansoni cercariae resulted in nearly 19% protection compared to 39% protection conferred to five baboons vaccinated with an irradiated vaccine. Vaccination with the anti-idiotypic antibodies resulted in a significant reduction of pathology and granuloma size following challenge with live unattenuated cercariae. Results presented in this work are considered highly significant because the anti-idiotypic vaccine markedly influenced schistosomiasis morbidity which is the main consideration in this disease.
Nyindo
M
M
Department of Parasitology, National Museums of Kenya, Nairobi, Kenya.
Borus
P K
PK
Farah
I O
IO
Oguya
F O
FO
Makawiti
D W
DW
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000276:immunology*; D000909:Antibodies, Helminth / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006099:Granuloma / Q000469:parasitology; D006801:Humans; D007116:Immunization, Passive; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000517:prevention & control; D010215:Papio; D010270:Parasite Egg Count; D011817:Rabbits; D012550:Schistosoma mansoni / Q000276:immunology* / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*
D000888:Antibodies, Anti-Idiotypic; D000909:Antibodies, Helminth