Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor.
Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1- benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylamin obenzamide), a selective dopamine D2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.
Yonezawa
Y
Y
Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kuroki
T
T
Tashiro
N
N
Hondo
H
H
Uchimura
H
H
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004357:Drug Synergism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D017551:Microdialysis; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001549:Benzamides; D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D018691:Excitatory Amino Acid Antagonists; D010622:Phencyclidine; C030265:nemonapride; D004298:Dopamine