title: Endotracheal intubation influences respiratory water loss during heat stress in young lambs.
abstract: To study the effect of intubation on respiratory water loss (RWL) during heat stress, 10 young nonsedated lambs were exposed to radiative heat stress both when intubated and when not. RWL, oxygen consumption (VO2), and carbon dioxide production were monitored continuously by using a flow-through system with a mass spectrometer for gas analysis. When the lambs were not intubated, heat stress caused RWL to increase by 218%, whereas VO2 and body temperature remained unchanged. When the lambs were intubated, heat stress caused RWL to increase by 131% and VO2 to increase by 36%. On extubation during heat stress, RWL increased by 117 +/- 48% (standard error of the estimate) of the preextubation value and body temperature started to fall. This study shows that intubation reduces the ability of the lamb to increase RWL and heat loss during heat stress in a warm environment, possibly as an effect of exclusion of the nose and a reduction in dead space. After extubation, RWL increases markedly, a finding that might also be valid for intubated infants.
authors.affiliation: Department of Paediatrics, Uppsala University, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Hammarlund
authors.forename: T
authors.initials: T
authors.lastname: Norsted
authors.forename: T
authors.initials: T
authors.lastname: Riesenfeld
authors.forename: G
authors.initials: G
authors.lastname: Sedin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018882:Heat Stress Disorders / Q000503:physiopathology*; D007442:Intubation, Intratracheal; D011659:Pulmonary Gas Exchange; D012756:Sheep; D014870:Water Loss, Insensible / Q000502:physiology*