title: Ethanol decreases basal cytosolic-free calcium concentration in cultured skeletal muscle cells.
abstract: We analysed the effect of ethanol on basal cytosolic-free calcium concentration ([Ca2+]i) in cultured rat myocytes. Ethanol caused a dose-dependent decrease of the resting [Ca2+]i. Removal of ethanol was followed by a transitory increase of [Ca2+]i above the basal level. In cells chronically exposed to ethanol, [Ca2+]i normalized to the previous level.
authors.affiliation: Department of Internal Medicine, Hospital Clínic, University of Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Cofán
authors.forename: J
authors.initials: J
authors.lastname: Fernandez-Solà
authors.forename: J M
authors.initials: JM
authors.lastname: Nicolás
authors.forename: E
authors.initials: E
authors.lastname: Poch
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Márquez
mesh_terms: D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D046508:Culture Techniques; D003600:Cytosol / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000431:Ethanol; D002118:Calcium