Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer.
PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.
Kovac
D
D
Department of Pathology, University of Rijeka, Croatia.
Rubinic
M
M
Krasevic
M
M
Krizanac
S
S
Petrovecki
M
M
Stimac
D
D
Melato
M
M
D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D015996:Survival Rate
D018809:Proliferating Cell Nuclear Antigen