title: Acute monocytic leukemia in a dog with X-linked severe combined immunodeficiency.
abstract: We describe the occurrence of acute monocytic leukemia in a dog with X-linked severe combined immunodeficiency (XSCID) that had been raised in a gnotobiotic environment for 20 months. This case represents the first reported instance of malignancy in canine XSCID, the first case of acute monocytic leukemia in any species with severe combined immunodeficiency, and the first documented malignancy in any species with XSCID that was not associated with immunotherapy.
authors.affiliation: Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania 19104, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Felsburg
authors.forename: R L
authors.initials: RL
authors.lastname: Somberg
authors.forename: G S
authors.initials: GS
authors.lastname: Krakowka
mesh_terms: D000818:Animals; D004285:Dogs; D008040:Genetic Linkage / Q000276:immunology; D005856:Germ-Free Life; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000473:pathology; D016511:Severe Combined Immunodeficiency / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D013154:Spleen / Q000276:immunology / Q000473:pathology; D014960:X Chromosome / Q000276:immunology