title: Severe arterial thrombosis in a congenitally factor VII deficient patient.
abstract: We report a patient with congenital factor VII deficiency who developed severe arterial thrombosis. A 63-year-old-woman presented low factor VII clotting activity, amidolytic activity and antigen level < 4%. Activated factor VII plasmatic level was < 0.03 ng/ml compared to 4 ng/ml for the control value. She developed severe aorto-iliac thrombosis. 7 d before the thrombotic event, factor VII replacement therapy had been infused. Successful low molecular weight heparin therapy led to total disappearance of the aorto-iliac thrombus without bleeding complications. This suggests that factor VII infusion might have a thrombogenic effect in vivo and might be responsible for thrombosis.
authors.affiliation: Service d'Angiohématologie, Hôpital Lariboisière, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Escoffre
authors.forename: J M
authors.initials: JM
authors.lastname: zini
authors.forename: L
authors.initials: L
authors.lastname: Schliamser
authors.forename: E
authors.initials: E
authors.lastname: Mazoyer
authors.forename: C
authors.initials: C
authors.lastname: Soria
authors.forename: G
authors.initials: G
authors.lastname: Tobelem
authors.forename: E
authors.initials: E
authors.lastname: Dupuy
mesh_terms: D001018:Aortic Diseases / Q000209:etiology*; D005168:Factor VII Deficiency / Q000150:complications* / Q000151:congenital; D005260:Female; D006801:Humans; D007083:Iliac Artery; D008875:Middle Aged; D013927:Thrombosis / Q000209:etiology*