Late juvenile metachromatic leukodystrophy treated with bone marrow transplantation; a 4-year follow-up study.
We treated a 28-year-old woman who had metachromatic leukodystrophy with bone marrow transplantation. Leukocyte arylsulfatase A levels increased to the donor's range after successful graft. Motor and sensory nerve conduction values did not change significantly in the 4 years after the transplant, and subcortical white matter lesions, as shown on MRI, remained stable during that period of time. The results, after 4 years of follow-up, indicate that the disease has not progressed and signs and symptoms are stabilized.
Navarro
C
C
Department of Pathology and Neuropathology, Hospital do Meixoeiro, Vigo, Spain.
Fernández
J M
JM
Domínguez
C
C
Fachal
C
C
Alvarez
M
M
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007966:Leukodystrophy, Metachromatic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D009431:Neural Conduction / Q000502:physiology; D013997:Time Factors