title: Initial clinical experience with the Baylor-Nikkiso centrifugal pump.
abstract: Recently, a newly developed centrifugal pump, the Baylor-Nikkiso pump, was approved for clinical use in the United States. This pump is the most compact centrifugal pump with a priming volume of only 25 ml. Although it is small, this pump can provide a flow of 4 L/min against a total pressure head of 300 mm Hg at 3,000 rpm. In vitro and in vivo validation of the Baylor-Nikkiso pump has proved that this pump could effectively reduce blood trauma even under high total head pressure. In addition, 48-h durability tests with biventricular bypass using calves verified the reliability of shaft sealing and antithrombogenicity. Clinical trials of the Baylor-Nikkiso pumps have been initiated in our department. This pump provides flows of 60-70 ml/kg/min with stable hemodynamic conditions. No leakage of thrombus formation was observed. The results of the initial clinical experience of the Baylor-Nikkiso pump suggest that it is suitable for cardiopulmonary bypass surgery.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ohtsubo
authors.forename: K
authors.initials: K
authors.lastname: Naito
authors.forename: M
authors.initials: M
authors.lastname: Matsuura
authors.forename: K
authors.initials: K
authors.lastname: Kawahito
authors.forename: T
authors.initials: T
authors.lastname: Shimono
authors.forename: K
authors.initials: K
authors.lastname: Makinouchi
authors.forename: K
authors.initials: K
authors.lastname: Tasai
authors.forename: Y
authors.initials: Y
authors.lastname: Ohara
authors.forename: G
authors.initials: G
authors.lastname: Damm
authors.forename: J
authors.initials: J
authors.lastname: Glueck
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001783:Blood Flow Velocity; D002315:Cardiopulmonary Bypass / Q000592:standards*; D002417:Cattle; D002498:Centrifugation; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass / Q000592:standards; D006353:Heart-Assist Devices / Q000592:standards* / Q000639:trends; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007260:Infusion Pumps / Q000592:standards*; D013927:Thrombosis / Q000517:prevention & control; D014481:United States
chemical_list: D001672:Biocompatible Materials