title: [Neurohumoral activity in liver cirrhosis].
abstract: The authors assessed in 40 patients with cirrhosis of the liver and in 33 controls the plasma renin activity (PRA), aldosterone (PA), the atrial natriuretic factor (ANF) and the digoxin like activity (DLA) in plasma under basal conditions. In patients with cirrhosis of the liver they found significantly lower levels of PRA, PA and DLA, as compared with the control group, the ANF levels were not significantly altered. In the group with cirrhosis the highest neuroendocrine activity was recorded, in particular of PRA and PA in decompensated cirrhotics receiving diuretic treatment. Therefore it is useful to combine diuretics with preparations or measures which reduce the activity of the renin-angiotensin-aldosterone system and/or promote the activity of natriuretic substances. The authors found a negative correlation between PRA and SNa, PRA and UNaV, while ANF did not correlate with natriuresis. The main determinant of Na excretion in decompensated cirrhosis is the activity of the renin-angiotensin-aldosterone system. DLA plasma levels also correlated inversely with SNa values and Na excretion and thus also reflect the severity of fluid retention.
authors.affiliation: II. interná klinika FN, Kosice.
authors.forename: I
authors.initials: I
authors.lastname: Lazúrová
authors.forename: I
authors.initials: I
authors.lastname: Rosochová
authors.forename: B
authors.initials: B
authors.lastname: Lichardus
authors.forename: D
authors.initials: D
authors.lastname: Trejbal
authors.forename: T
authors.initials: T
authors.lastname: Hildebrand
authors.forename: I
authors.initials: I
authors.lastname: Tkác
authors.forename: Y
authors.initials: Y
authors.lastname: Machánová
authors.forename: J
authors.initials: J
authors.lastname: Murár
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D002298:Cardenolides; D004077:Digoxin; D004231:Diuresis; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D018377:Neurotransmitter Agents / Q000097:blood*; D012083:Renin / Q000097:blood; D012503:Saponins
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D018377:Neurotransmitter Agents; D012503:Saponins; C034504:digoxin-like factors; D000450:Aldosterone; D004077:Digoxin; D009320:Atrial Natriuretic Factor; D012083:Renin
vernacular_title: Neurohumorálna aktivita pri cirhóze pecene.