A single-blind study of podophyllotoxin cream 0.5% and podophyllotoxin solution 0.5% in male patients with genital warts.
OBJECTIVE
To evaluate the efficacy-safety ratio of a new topical podophyllotoxin cream 0.5% compared with podophyllotoxin solution 0.5% (Condyline) in male patients with genital warts.


METHODS
In an observer-blinded controlled study a total of 136 and 133 wart lesions were treated with podophyllotoxin cream 0.5% and podophyllotoxin solution 0.5%, respectively. The preparations were applied twice daily for 3 days, repeated with 4 days intervals for a minimum of two and a maximum of four treatment cycles.


RESULTS
At the conclusion of the study (8 weeks after completion of therapy) a significant reduction in mean wart area was observed in both the cream group (87.7, SD 8.4 to 20.6, SD 2.7) and in the solution group (92.3, SD 7.5 to 21.5, SD 2.8) (p < 0.01). At the same time all treated warts had completely cleared in 63% of patients in both study groups. Mild to moderate side effects occurred to the same extent in both podophyllotoxin cream and podophyllotoxin solution recipients.


CONCLUSIONS
We conclude that podophyllotoxin 0.5% administered in a cream formulation does not give additional clinical benefits when compared with podophyllotoxin solution 0.5% in male patients with external genital warts.
Petersen
C S
CS
Department of Dermato-venereology, Gentofte Hospital, University of Copenhagen, Denmark.
Agner
T
T
Ottevanger
V
V
Larsen
J
J
Ravnborg
L
L
D000287:Administration, Topical; D000328:Adult; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009824:Ointments; D010409:Penile Diseases / Q000188:drug therapy* / Q000821:virology; D011034:Podophyllotoxin / Q000008:administration & dosage* / Q000009:adverse effects; D016037:Single-Blind Method; D012996:Solutions; D016896:Treatment Outcome
D007641:Keratolytic Agents; D009824:Ointments; D012996:Solutions; D011034:Podophyllotoxin