title: [Bone metastasis of leiomyosarcoma. Apropos of a case].
abstract: BACKGROUND
  Bone leiomyosarcoma is a rare tumor, whether it may be primary or secondary. The authors report on the case of a woman, aged 67, admitted in January 1992 complaining of pain in the left hip and the upper end of the femur.
  
  
  METHODS
  In 1985 the patient underwent surgical excision of a soft tissue tumor in the right thigh, histologically diagnosed as a benign fibrous tumor. This lesion recurred locally four times and repeated excisions were performed throughout the years, always with a histological diagnosis of a benign lesion. On admission to hospital, the physical examination as well as laboratory data and plain roentgenograms were unremarkable. Both tomography and MRI showed a lesion in the upper end of the left femur. An isotopic bone scan showed marked increased uptake in the left hip extending to the femoral diaphysis. An open biopsy was performed for histology, immunohistochemistry and electron microscopy. A diagnosis of metastatic leiomyosarcoma was made. The retrospective histological examination of specimens of the soft tissue tumor excised in 1985 showed the same immunohistochemical features of the contralateral leiomyosarcoma. On this basis, one stage resection of the left hip and the upper end of the femur was performed and a Kotz modular prosthesis was inserted. Postoperative healing was achieved without any complications and the function of the operated limb was satisfactory. Three months after the operation pulmonary lesions were noted on chest radiographs and CT scan. The patient died two years after the first admission for widespread metastasis.
  
  
  CONCLUSIONS
  In the reported case, the bony metastasis appeared to be the presenting finding of the soft tissue tumor of the contralateral thigh. This presentation is rare in previously published series. The misdiagnosis of the primary tumor had caused local recurrences, and an increased malignity occurred. According to the literature, a soft tissue leiomyosarcoma can be easily confused with other spindle cell lesions. Therefore an accurate histological and ultrastructural diagnosis is necessary for adequate surgical treatment.
authors.affiliation: Clinique Orthopédique, Faculté de Médecine de Catanzaro, Université de Reggio Calabria, Italie.
authors.forename: M
authors.initials: M
authors.lastname: Mariconda
authors.forename: C
authors.initials: C
authors.lastname: Tacchetti
authors.forename: C M
authors.initials: CM
authors.lastname: Misiti
authors.forename: G
authors.initials: G
authors.lastname: Lotti
authors.forename: A
authors.initials: A
authors.lastname: Ammendolia
authors.forename: R
authors.initials: R
authors.lastname: Millo
authors.forename: C
authors.initials: C
authors.lastname: Milano
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D001984:Bronchial Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005269:Femur; D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D011859:Radiography; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000601:surgery; D013848:Thigh
vernacular_title: Métastase osseuse d'un leiomyosarcome. A propos d'un cas.