Whole-body retention and fetal uptake of 65Zn in pregnant mice fed a Zn-deficient diet.
Whole-body retention and fetal uptake of 65Zn under a Zn-deficient diet were studied in pregnant mice in the late gestational stage after a single oral administration of 65Zn. Whole-body retentions were much greater in mice given a Zn-deficient diet than in those given a Zn-normal diet. Accordingly, the amount of 65Zn transmitted to the offspring in utero was greater in the Zn-deficient diet group. In another experiment, fetal uptake of 65Zn in dams on gestation day 17 was examined over a period of 24 hr after a single intravenous administration of 65Zn to the Zn-deficient and Zn-normal animals. There was no major difference in fetal uptake between the two groups, indicative that approximately a similar proportion of the 65Zn retained in the maternal body was transmitted to the in utero offspring in both groups.
Matsusaka
N
N
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Japan.
Sakamoto
H
H
Sato
I
I
Shinagawa
K
K
Kobayashi
H
H
Nishimura
Y
Y
D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency*; D015037:Zinc Radioisotopes / Q000493:pharmacokinetics*
D015037:Zinc Radioisotopes; D015032:Zinc