title: A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.
abstract: A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
authors.affiliation: Department of Medical Oncology, Imperial Cancer Research Fund, St. Bartholomew's Hospital, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Meerabux
authors.forename: M L
authors.initials: ML
authors.lastname: Yaspo
authors.forename: A J
authors.initials: AJ
authors.lastname: Roebroek
authors.forename: W J
authors.initials: WJ
authors.lastname: Van de Ven
authors.forename: T A
authors.initials: TA
authors.lastname: Lister
authors.forename: B D
authors.initials: BD
authors.lastname: Young
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D003001:Cloning, Molecular; D015321:Gene Rearrangement; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D012697:Serine Endopeptidases / Q000235:genetics*; D013381:Subtilisins; D014178:Translocation, Genetic
chemical_list: C099101:PCSK7 protein, human; D012697:Serine Endopeptidases; D013381:Subtilisins