[The biochemical changes in the brain synaptosomes during the gamma irradiation of mice at a low dose with different intensities].
Some characteristics of mice brain nerve-endings' lipid phase were studied (total lipids, total and individual phospholipids and cholesterol contents, their ratios, lipid peroxidation level, rigidity index) after single low dose, whole body gamma-irradiation (15 cGy) with dose intensities of 0.01, 0.25, 9.0 cGy/min. Some markedly expressed alterations were found out in those parameters. Brain membranes functioning also changed significantly as it was judged by membrane-bound acetylcholinesterase activity. All the changes revealed complicated dependence both on dose intensity and on time period after irradiation. The ranges of the observed changes suppose CNS state to have been modified by low dose irradiation including CNS sensibility to external psycho- and neurotrophic factors.
Molochkina
E M
EM
Dzhaman
U M
UM
Ozerova
I B
IB
Burlakova
E B
EB
Shishkina
L N
LN
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D001923:Brain Chemistry / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000528:radiation effects; D008055:Lipids / Q000032:analysis / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009411:Nerve Endings / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects; D018709:Statistics, Nonparametric; D013574:Synaptosomes / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014916:Whole-Body Irradiation
D008055:Lipids
Biokhimicheskie izmeneniia v sinaptosomakh golovnogo mozga pri gamma-obluchenii mysheĭ maloĭ dozoĭ s raznoĭ intensivnost'iu.