Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus).
A malignant melanocytic tumor was found in an 8-week-old chicken. The tumor, which was composed of melanocytes, ganglion cells, nerves, and primitive pressure receptors, was examined by light microscopy, transmission electron microscopy, and immunohistochemistry. Antibodies to neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein variably stained nerves, but melanocytes were only rarely immunolabelled by NSE antibodies and there was no specific staining of these cells for S-100 or GFAP. Ultrastructurally, neoplastic melanocytes contained melanin within melanosomes and premelanosomes and did not resemble Schwann cells.
Hafner
S
S
Latimer
K
K
Kelley
L C
LC
Wortham
K
K
Puette
M
M
D000310:Adrenal Gland Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry; D008545:Melanoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron / Q000662:veterinary; D009432:Neural Crest / Q000473:pathology*; D011201:Poultry Diseases / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000473:pathology
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins