title: Changes in T-cell subpopulations in mice during prolonged experimental secondary infection with Echinococcus granulosus.
abstract: Balb/c mice were infected intraperitoneally with protoscoleces of Echinococcus granulosus. After 15 months of infection, and by means of flow cytometry, the expression of T-cell markers CD3, CD4, and CD8 on T cells from peripheral blood, spleen, and thymus was analyzed and compared with that of age-matched controls. Infected mice had higher percentages of CD3+, and CD4+ cells in peripheral blood, and higher percentages of CD8+ cells in the spleen, when compared with control mice. CD4+ and CD8+ cells in peripheral blood and CD8+ cells in thymus also showed higher percentages of expression of interleukin-2 receptor. The results infer a role for interleukin-2 in experimental secondary echinococcosis.
authors.affiliation: Laboratorio de Análisis, Hospital Torrecardenas, Almería, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Rueda
authors.forename: A
authors.initials: A
authors.lastname: Osuna
authors.forename: P H
authors.initials: PH
authors.lastname: De Rycke
authors.forename: D
authors.initials: D
authors.lastname: Janssen
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000032:analysis; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000469:parasitology; D018414:CD8-Positive T-Lymphocytes / Q000469:parasitology; D004443:Echinococcosis / Q000097:blood / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D051379:Mice; D008807:Mice, Inbred BALB C; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000378:metabolism / Q000469:parasitology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology; D013997:Time Factors
chemical_list: D017252:CD3 Complex; D015375:Receptors, Interleukin-2