[Determination of the general prothrombin level and detection of its functionally inactive forms using the enzyme ecamulin purified from Echis multisquamatus venom].
The method for determination of the general prothrombin level and detection of its inactive forms (prothrombin-1, decarboxylated prothrombin, etc.) has been worked out. Enzyme ecamulin was purified from the venom of Echis multisquamatus. Ecamulin test was used for plasma of practically healthy people and patients with hypertension. The results obtained proved that this test is informative and precise. Comparison of two tests, prothrombin and ecamulin ones, permits characterizing the state of blood coagulation and finding functionally inactive prothrombin forms which are the markers of some pathological states.
Platonova
T N
TN
Sushko
E A
EA
Petrov
A V
AV
Solov'ev
D A
DA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D004796:Clinical Enzyme Tests; D004795:Enzyme Stability; D004798:Enzymes / Q000302:isolation & purification*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008875:Middle Aged; D011516:Prothrombin / Q000378:metabolism*; D012016:Reference Values; D013379:Substrate Specificity; D014757:Viper Venoms / Q000201:enzymology*
D001779:Blood Coagulation Factors; D004798:Enzymes; D014757:Viper Venoms; D011516:Prothrombin
Opredelenie obshchego urovnia protrombina i vyiavlenie ego funktsional'no neaktivnykh form s pomoshch'iu fermenta ékamulina, vydelennogo iz iada éfy mnogocheshuĭchatoĭ.