Spontaneous pregnancy in women awaiting oocyte donation.
OBJECTIVE
To evaluate the rate of spontaneous pregnancy in women awaiting oocyte donation.


METHODS
Two hundred women with histories of hypergonadotropic hypogonadism (follicle-stimulating hormone > 60 mIU/mL, estradiol < 20 pg/mL) were evaluated for oocyte donation.


RESULTS
While awaiting gamete donation, five women (2.5% of patients monitored) spontaneously conceived. Their ages ranged from 32 to 42 years (mean, 37.0 +/- 5.0) (mean +/- SD). Conceptions occurred 5.0 +/- 2.6 years (range, two to eight) from their original diagnosis, while they were using hormone replacement therapy. Four of the five pregnancies continued uneventfully, and one patient spontaneously aborted. Subsequently all women demonstrated elevated serum gonadotropins and amenorrhea.


CONCLUSIONS
Patients with hypergonadotropic hypogonadism may spontaneously conceive while awaiting oocyte donation.
Sauer
M V
MV
Department of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.
D000328:Adult; D015914:Estrogen Replacement Therapy; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy
D006062:Gonadotropins