Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff "taranome," the young shoot of Aralia elata SEEM.: elatosides G, H, I, J, and K.
Five new saponins named elatosides G, H, I, J, and K were isolated from a garnish foodstuff "Taranome," the young shoot of Aralia elata SEEM., together with hederagenin-3-O-glucuronopyranoside and elatoside C. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. Elatosides G, H, and I were found to exhibit potent hypoglycemic activity in the oral glucose tolerance test in rats.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Yoshizumi
S
S
Ueno
T
T
Matsuda
H
H
Murakami
T
T
Yamahara
J
J
Murakami
N
N
D000704:Analysis of Variance; D000818:Animals; D005591:Chemical Fractionation; D002851:Chromatography, High Pressure Liquid; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
D007004:Hypoglycemic Agents; D012503:Saponins; C098089:elatoside G; C098090:elatoside H; C098091:elatoside I; C098092:elatoside J; C098093:elatoside K; D009828:Oleanolic Acid