title: Are bacterial proteinases pathogenic factors?
abstract: Evidence is rapidly accumulating that suggests that the growth and proliferation of pathogenic bacteria depend on proteolytic enzymes of the invading organism and of the host. Proteinase inhibitors targeting bacterial proteinases may be useful antimicrobial agents.
authors.affiliation: Dept of Biochemistry, University of Georgia, Athens 30602, USA.
authors.forename: J
authors.initials: J
authors.lastname: Travis
authors.forename: J
authors.initials: J
authors.lastname: Potempa
authors.forename: H
authors.initials: H
authors.lastname: Maeda
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001426:Bacterial Proteins / Q000187:drug effects / Q000502:physiology*; D010450:Endopeptidases / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D007705:Kinins / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D007705:Kinins; D011480:Protease Inhibitors; D010450:Endopeptidases; D007610:Kallikreins