title: Low pulsatility signals through the orbits.
abstract: OBJECTIVE
  Low pulsatility signals (LPS) on transcranial Doppler ultrasonography are detected (1) with arteriovenous malformations, (2) distal to hemodynamically significant stenosis, and (3) in venous structures. We describe focal LPS in the territory of the internal carotid artery siphon that do not represent any of the above conditions.
  
  
  METHODS
  We performed retrospective and prospective reviews of transcranial Doppler studies on 3225 patients over 5 years. Clinical and radiological data of all patients with focal LPS were extracted. LPS was defined as a focal signal identified through the orbital windows with a low pulsatility index (< 0.6).
  
  
  RESULTS
  Sixteen LPS (mean flow velocity [mean +/- SD], 62 +/- 11 cm/s; pulsatility index [mean +/- SD], 0.41 +/- 0.08; depth range, 46 to 72 mm) from 15 patients (mean +/- SD age, 45 +/- 15 years; 4 men, 11 women) were identified. LPS flow direction was away from the probe in 13 cases and toward it in 3. Presenting symptoms included headache, focal neurological deficits, dizziness, and pulsatile tinnitus. All patients had cranial MRI (MRI and MR angiography in 11). Three patients underwent conventional cerebral angiography. Arteriovenous malformations or significant arterial stenoses were not detected on any study.
  
  
  CONCLUSIONS
  A focal signal from the internal carotid artery siphon region with low pulsatility index and normal mean flow velocity, identified in the absence of other transcranial Doppler abnormalities, is not related to an arteriovenous malformation or proximal arterial stenosis. LPS, as defined, are not of venous origin since mean flow velocity was in the arterial range. LPS are likely related to prominent venous flow in the cavernous sinus secondary to unusually strong pulsation of the intracavernous internal carotid artery.
authors.affiliation: Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, Mich. 48202, USA.
authors.forename: C
authors.initials: C
authors.lastname: Gymnopoulos
authors.forename: N M
authors.initials: NM
authors.lastname: Ramadan
mesh_terms: D001783:Blood Flow Velocity; D016893:Carotid Stenosis / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D013599:Systole; D017585:Ultrasonography, Doppler, Transcranial