Inhibitory effects of phenolic carboxylic acid analogues on xanthine oxidase.
Nineteen phenolic carboxylic acid analogues were tested for the effects on xanthine oxidase inhibition. 2,2',4,'4'-Tetrahydroxybenzophenone and 2,3,4-trihydroxybenzoic acid displayed the strongest activities (IC50 = 38.70 microM, IC50 = 90.16 microM respectively). Their apparent inhibition constants (Ki) were 7.052 and 0.535 microM respectively, and induced mixed type and competitive type inhibitions respectively with respect to the substrate xanthine.
Chang
W S
WS
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, ROC.
Yan
G F
GF
Chiang
H C
HC
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D002264:Carboxylic Acids / Q000494:pharmacology*; D017665:Hydroxyl Radical; D010636:Phenols / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D002264:Carboxylic Acids; D010636:Phenols; D017665:Hydroxyl Radical; D000449:Aldehyde Reductase; D014969:Xanthine Oxidase