[Allogeneic transplantation and HIV infection: studies of HIV-infected tissue].
BACKGROUND
Because of the limited availability of autologous tissue, stored allograft is commonly used. Before grafting, bank tissue is subjected to chemical preservation procedures. This procedure is important to diminish antigenicity and to inactivate possible inherent viruses. The aim of this study was to determine the influence of different chemical preservation procedures like Cialit, Merthiolate, and formaldehyde on the presence of HIV DNA.


METHODS
HIV-infected tissues were obtained from eight HIV-positive patients and examined using the polymerase chain reaction (PCR).


RESULTS
After chemical treatment, we could observe the presence of HIV DNA in all examined tissues.


CONCLUSIONS
The findings indicate the importance of the mandatory serological screening and selection in donor patients.
Bujía
J
J
Klinik und Poliklinik für Hals-Nasen- und Ohrenkranke.
Kastenbauer
E
E
Wilmes
E
E
Gürtler
L
L
D000328:Adult; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006678:HIV / Q000235:genetics; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
D004279:DNA, Viral
Allogene Transplantation und HIV-Infektion: Untersuchungen an HIV-infiziertem Gewebe.