The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy.
In order to elucidate the role of macrophage in lipid-induced nephrotoxicity in diabetic nephropathy, we examined the effect of macrophage colony-stimulating factor (M-CSF) on the progression of renal lesions in hypercholesterolemic steptozotocin (STZ)-diabetic rats fed with high cholesterol chow. Hypercholesterolemia aggravated albuminuria in diabetic rats accompanied by infiltration of macrophages in glomeruli. Treatment with M-CSF suppressed simultaneously infiltration of glomerular macrophages and urinary albumin excretion in hypercholesterolemic diabetic rats. These results suggest that infiltration of glomerular macrophage has a primary role in lipid-induced nephrotoxicity in diabetic nephropathy, and M-CSF is involved in this process as a preventive factor.
Utsunomiya
K
K
Third Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Ohta
H
H
Kurata
H
H
Tajima
N
N
Isogai
Y
Y
D000419:Albuminuria / Q000517:prevention & control; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000633:toxicity*; D019826:Cholic Acid; D002793:Cholic Acids / Q000633:toxicity*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D006949:Hyperlipidemias / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology
D002791:Cholesterol, Dietary; D002793:Cholic Acids; D011994:Recombinant Proteins; D016173:Macrophage Colony-Stimulating Factor; D019826:Cholic Acid