title: Does a routine operation for intracranial aneurysm incur brain damage?
abstract: A biochemical marker of brain cell damage, the BB-isozyme of the intracellular enzyme Creatine Kinase (CK), was used to evaluate any possible injury to the brain, caused by an operation for a ruptured intracranial aneurysm (SAH). CSF-CK BB was assessed before and at intervals after operation in a series of 60 patients, aged 29-71 (mean 51 years) operated on for intracranial aneurysms, all but one after SAH. The m/f ratio was 18/42. 35 of the 60 patients were operated on acutely, i.e. within 72 hours after the SAH. CK BB was determined as CKB-activity after immunological inactivation of CKM. Normally there should be almost no detectable enzyme activity in the CSF. The pre-operative CK BB-activity was 0.01+ -0.01 mikrokatal in the patients in Hunt & Hess grade I who were operated on > 7 days after their SAH, and 0.05+ -0.04 in those operated on acutely, probably still reflecting the effects of the SAH on the brain. The mean per-operative CK BB increase was 0.11+ -0.17 for patients who had an uneventful postoperative course, compared to 0.39+ -0.49 for those showing some degree of immediate postoperative deterioration. This difference is significant at the 1% level. 52 of the 60 patients showed a rise of CK BB after operation. The mean increase for those patients operated upon in a good state and without any complication or postoperative deterioration was 0.02+ -0.03 mikrokatal, which could therefore be considered as a "normal" or acceptable elevation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neurosurgery, Norrland University Hospital, Umeå, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Rabow
authors.forename: G
authors.initials: G
authors.lastname: Algers
authors.forename: J
authors.initials: J
authors.lastname: Elfversson
authors.forename: P A
authors.initials: PA
authors.lastname: Ridderheim
authors.forename: O
authors.initials: O
authors.lastname: Rudolphi
authors.forename: S
authors.initials: S
authors.lastname: Zygmunt
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000201:enzymology / Q000601:surgery*; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000201:enzymology / Q000601:surgery*; D002546:Ischemic Attack, Transient / Q000175:diagnosis / Q000201:enzymology; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011183:Postoperative Complications / Q000175:diagnosis* / Q000201:enzymology; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000201:enzymology / Q000601:surgery*
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase; D010751:Phosphopyruvate Hydratase