Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli.
The leucine-responsive regulatory protein (Lrp) regulates transcription of the many genes of the Lrp regulon, repressing some and activating others, some in response to L-leucine and some independent of it. The physiology and molecular biology of the regulon in Escherichia coli are summarized here. However, the high degree of conservation of the protein suggests that it has an important role in all enterobacteria. We suggest that this role is not only as a transcriptional regulator but also as a determinant of chromosome structure.
Newman
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Biology Department, Concordia University, Montreal, Quebec, Canada.
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D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D007930:Leucine / Q000378:metabolism; D051756:Leucine-Responsive Regulatory Protein; D008969:Molecular Sequence Data; D009154:Mutation; D009876:Operon / Q000235:genetics; D011485:Protein Binding; D018085:Regulon; D014157:Transcription Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C497278:Lrp protein, E coli; D014157:Transcription Factors; D051756:Leucine-Responsive Regulatory Protein; D007930:Leucine