[A mathematical model of the changes in bone marrow cellularity in radiation exposures].
The model is based on classical ideas about of hemopoiesis in normal conditions and under irradiation. It consists of only two equations characterizing stem and differentiated bone marrow cell dynamics. The systemic mechanisms of hemopoiesis regulation were roughly taken into account. The formulae suitable for calculations of equilibrium cell concentrations under prolonged irradiation were derived. The model was shown to be in agreement with experimental data on hemopoietic system changes under acute and prolonged irradiation of rodents and dogs. The model is intended for describing the extent of hemopoiesis disturbance under those modes of mammalian exposure when describing of general regularities is enough.
Gubin
A T
AT
Sakovich
V A
VA
Shafirkin
A V
AV
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects; D006801:Humans; D008322:Mammals; D008433:Mathematics; D008954:Models, Biological
Matematicheskaia model' izmeneniĭ kletochnosti kostnogo mozga pri radiatsionnykh vozdeĭstviiakh.