Intrathecal baclofen for motor disorders.
To test the efficacy of intrathecal baclofen in various movement disorders, 18 patients with dystonia, head trauma, cerebral palsy, rigidity, or painful spasms underwent a trial of intrathecal baclofen. Ten went on to permanent implantation with an infusion pump to provide long-term treatment. Patients with a component of spasticity, painful spasms, or focal dystonias did best, and no response was seen in patients with rigidity due to anoxic encephalopathy. A videotape of responses is provided.
Penn
R D
RD
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.
Gianino
J M
JM
York
M M
MM
D000293:Adolescent; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage* / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications; D006259:Craniocerebral Trauma / Q000150:complications; D004421:Dystonia / Q000150:complications; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy* / Q000209:etiology; D009125:Muscle Relaxants, Central / Q000008:administration & dosage* / Q000627:therapeutic use*; D009127:Muscle Rigidity / Q000150:complications; D009128:Muscle Spasticity / Q000150:complications; D016896:Treatment Outcome; D014743:Videotape Recording
D009125:Muscle Relaxants, Central; D001418:Baclofen