Cyclic ADP-ribose, the ryanodine receptor and Ca2+ release.
In a variety of vertebrate and invertebrate tissues the ryanodine-sensitive Ca2+ channel is the pathway for Ca2+ release from intracellular stores. The mechanism for activation of the ryanodine receptor-channel complex appears to depend both on the ryanodine receptor isoform and the cell type. In addition, a complex combination of endogenous intracellular compounds regulates channel gating. In this article, Rebecca Sitsapesan, Stephen McGarry and Alan Williams review the mechanisms involved in cyclic ADP-ribose (cADPR)-induced Ca2+ release and discuss the likelihood that cADPR-activated Ca2+ release is mediated by one of the recognized isoforms of the ryanodine receptor-Ca2+ channel complex.
Sitsapesan
R
R
National Heart and Lung Institute, Imperial College, London, UK.
McGarry
S J
SJ
Williams
A J
AJ
D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002110:Caffeine / Q000378:metabolism / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism / Q000494:pharmacology; D002148:Calmodulin-Binding Proteins / Q000187:drug effects / Q000378:metabolism*; D036563:Cyclic ADP-Ribose; D015640:Ion Channel Gating / Q000187:drug effects*; D007527:Isoenzymes; D009124:Muscle Proteins / Q000187:drug effects / Q000378:metabolism*; D011869:Radioligand Assay; D012433:Ryanodine / Q000378:metabolism / Q000494:pharmacology; D019837:Ryanodine Receptor Calcium Release Channel; D012617:Sea Urchins
D015220:Calcium Channels; D002147:Calmodulin; D002148:Calmodulin-Binding Proteins; D007527:Isoenzymes; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel; D036563:Cyclic ADP-Ribose; D012433:Ryanodine; D000246:Adenosine Diphosphate Ribose; D002110:Caffeine; D000255:Adenosine Triphosphate; D002118:Calcium