Changes in G protein levels in the hippocampus and the striatum of rat brain after chronic treatment with haloperidol and sulpiride.
Treatment with either haloperidol or sulpiride for 14 days increased the levels of Gs alpha and Gi alpha in the rat hippocampus, but decreased those of Golf alpha and Gi alpha in the rat striatum. Levels of Gq alpha/G11 alpha and Go alpha were not affected by the drugs. These results demonstrate that haloperidol and sulpiride regulate G protein expression in the hippocampus and striatum quite differently.
Shin
C J
CJ
Department of Psychiatry, Seoul National University College of Medicine, Chongno-gu, Korea.
Kim
Y S
YS
Park
J B
JB
Juhnn
Y S
YS
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D019204:GTP-Binding Proteins / Q000032:analysis*; D006220:Haloperidol / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013469:Sulpiride / Q000494:pharmacology*
D013469:Sulpiride; D019204:GTP-Binding Proteins; D006220:Haloperidol