title: Visible light anaerobic photoconversion of tyrosine sensitized by riboflavin. Cytotoxicity on mouse tumoral cells.
abstract: The anaerobic phototransformation of tyrosine under visible light sensitized by riboflavin is reported. The cytotoxicity of the anaerobic photoproducts on in vitro-cultured myeloid mouse tumoral cells was demonstrated. A radical mechanism is proposed. Dityrosine was identified as one of the main anaerobic photoproducts by using absorption, emission and 1H-NMR spectra.
authors.affiliation: Facultad de Química (536), P. Universidad Católica de Chile, Santiago, Chile.
authors.forename: E
authors.initials: E
authors.lastname: Silva
authors.forename: S
authors.initials: S
authors.lastname: Fürst
authors.forename: A M
authors.initials: AM
authors.lastname: Edwards
authors.forename: M I
authors.initials: MI
authors.lastname: Becker
authors.forename: A E
authors.initials: AE
authors.lastname: De Ioannes
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D004347:Drug Interactions; D007951:Leukemia, Myeloid / Q000628:therapy*; D008027:Light; D051379:Mice; D010777:Photochemistry; D010789:Phototherapy; D012256:Riboflavin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D014443:Tyrosine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D014443:Tyrosine; D012256:Riboflavin