A new rat model for studying the calpain-calpastatin system.
A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.
Soldati
L P
LP
Department of Sciences and Biomedical Technologies, University of Milan, Italy.
Barber
B R
BR
Salardi
S
S
Molinari
I
I
Bianchi
G
G
D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D002154:Calpain / Q000502:physiology*; D003433:Crosses, Genetic; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics / Q000502:physiology*; D005260:Female; D005838:Genotype; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic
D002135:Calcium-Binding Proteins; D015853:Cysteine Proteinase Inhibitors; C033668:calpastatin; D002154:Calpain