Glassy cell carcinoma of the colon with human chorionic gonadotropin-production. A case report with immunohistochemical and ultrastructural analysis.
An unusual tumor in the descending colon with human chorionic gonadotropin-beta (HCG-beta) production and histological features of a "glassy cell" carcinoma is presented. Glassy cell carcinoma has been described in the uterus and fallopian tubes as well as the cervix, but in these locations the tumor is not HCG-beta producing. Glassy cell carcinomas have been described in some cases as having glandular and squamous differentiation as well as marked cellular pleomorphism. The tumors are generally associated with a poor prognosis.
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Department of Pathology, Frederiksborg County Hospital, Copenhagen, Denmark.
Rasmussen
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Federspiel
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Horn
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D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D003110:Colonic Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D003598:Cytoskeletal Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D018396:Mucin-1 / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D011379:Prognosis; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D053379:Chromogranin A; D002864:Chromogranins; D003598:Cytoskeletal Proteins; D018396:Mucin-1; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins