title: The evolution of platelet aggregability in patients undergoing catheter ablation for supraventricular tachycardia with radiofrequency energy: the role of antiplatelet therapy.
abstract: Forty-two consecutive patients were checked for profiles of platelet aggregability before, during, and 10 and 30 minutes after catheter ablation. They were randomized into Group A (n = 20) who accepted intravenous aspirin (in 0.015 g/kg body weight) and Group P (n = 22) who accepted only placebo treatment. Blood samples were drawn from ascending aorta (Ao) and main pulmonary artery (MPA) simultaneously at each time period. In Group P, the EC50 of substrate induced platelet aggregability decreases significantly during (for ADP, from 1.72 to 0.78 mumol/L for samples from Ao, P < 0.0001; and from 1.68 to 0.69 mumol/L for MPA, P < 0.0001; for collagen, from 2.26 to 1.34 micrograms/mL for Ao, P < 0.005, and from 2.40 to 1.64 micrograms/mL, P < 0.0001) and 10 minutes after successful ablation (for ADP, to 0.70 mumol/L for Ao, P < 0.000, and to 0.61 mumol/L for MPA, P < 0.0001; for collagen, to 1.54 micrograms/mL for Ao, P < 0.01, and to 1.63 micrograms/mL, P < 0.0001), and then returned to baseline levels 30 minutes later (all P = NS) compared with comparative baseline levels. The levels of thromboxane B2 (TXB2) had the similar evolution. The evolution of platelet aggregability profiles was not associated with total energy dose, duration of energy application, duration of procedure, impedance, and ablation site. However, there were moderate positive correlations between the TXB2 levels and tip temperatures (r = 0.56, P < 0.05 for Ao and r = 0.65, P < 0.01 for MPA). These results suggest that increased platelet aggregability can occur during and 10 minutes after radiofrequency current ablation and antiplatelet therapy can maintain "flat" response of platelet aggregability to radiofrequency energy, which may provide possible benefits in preventing the occurrence of the complication.
authors.affiliation: Department of Emergency Medicine, Hsin-Kong Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: T L
authors.initials: TL
authors.lastname: Wang
authors.forename: J L
authors.initials: JL
authors.lastname: Lin
authors.forename: J J
authors.initials: JJ
authors.lastname: Hwang
authors.forename: C D
authors.initials: CD
authors.lastname: Tseng
authors.forename: H M
authors.initials: HM
authors.lastname: Lo
authors.forename: W P
authors.initials: WP
authors.lastname: Lien
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Tseng
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001011:Aorta; D001241:Aspirin / Q000627:therapeutic use; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods; D003094:Collagen / Q000494:pharmacology; D017097:Electric Impedance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D010919:Placebos; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011182:Postoperative Care; D011651:Pulmonary Artery; D013617:Tachycardia, Supraventricular / Q000097:blood / Q000601:surgery*; D013696:Temperature; D013929:Thromboxane B2 / Q000097:blood; D013997:Time Factors
chemical_list: D010919:Placebos; D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D000244:Adenosine Diphosphate; D003094:Collagen; D001241:Aspirin