Enhancement of biliary carcinogenesis in hamsters by cholecystokinin.
We recently developed a new model for rapid and reproducible induction of biliary carcinoma in hamsters. In the present study, we evaluated the effects of cholecystokinin (CCK), which has a trophic action on the gastrointestinal tract and on the pancreaticobiliary system, on biliary carcinogenesis in this hamster model. Hamsters treated with N-nitrosobis (2-oxopropyl) amine (BOP) were divided into four groups: In Group I, hydrolyzed gelatin, a solvent of CCK, was injected subcutaneously. In Groups II and III, CCK 2.5 and 25 microgram/kg were administered, respectively. In Group IV loxiglumide, a CCK receptor antagonist, was administered. CCK significantly promoted the carcinogenetic effect of BOP in the intra- and extrahepatic bile ducts but not in the gallbladder or pancreas. Loxiglumide exerted an inhibitory effect on carcinogenesis in the intrahepatic bile duct.
Ikematsu
Y
Y
Second Department of Surgery, Nagasaki University School of Medicine, Japan.
Tomioka
T
T
Tajima
Y
Y
Tsunoda
T
T
Kanematsu
T
T
D000704:Analysis of Variance; D000818:Animals; D001661:Biliary Tract Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D002273:Carcinogens; D002766:Cholecystokinin / Q000633:toxicity*; D006224:Cricetinae; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology; D008647:Mesocricetus; D009602:Nitrosamines; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors
D002273:Carcinogens; D006727:Hormone Antagonists; D009602:Nitrosamines; D011949:Receptors, Cholecystokinin; C013622:nitrosobis(2-oxopropyl)amine; C053737:loxiglumide; D002766:Cholecystokinin; D011377:Proglumide