Isoforms of glucose transporter in the iris-ciliary body.
Isoforms of the facilitated glucose transporter (GLUT) were identified in the iris-ciliary body. Western blot analysis showed that GLUT1 and GLUT4 proteins were expressed in the rat iris-ciliary body. In addition, the content of GLUT proteins in the rabbit iris-ciliary body was estimated by specific [3H]cytochalasin B binding assay. The content of GLUT proteins was found to be more abundant in the iris-ciliary body than in the cerebral cortex. The utilization of glucose in the iris-ciliary body and the transport of glucose into the aqueous humor are suggested to be mediated by GLUT1 and GLUT4 proteins.
Tsukamoto
H
H
Department of Ophthalmology, Hiroshima University School of Medicine, Japan.
Mishima
H K
HK
Kurokawa
T
T
Kiuchi
Y
Y
Sato
E
E
Ishibashi
S
S
D000818:Animals; D015153:Blotting, Western; D002540:Cerebral Cortex / Q000737:chemistry; D002924:Ciliary Body / Q000737:chemistry*; D003571:Cytochalasin B / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D007498:Iris / Q000737:chemistry*; D009004:Monosaccharide Transport Proteins / Q000032:analysis* / Q000378:metabolism; D009124:Muscle Proteins; D011817:Rabbits; D051381:Rats
D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495679:Slc2a1 protein, rat; C495694:Slc2a4 protein, rat; D003571:Cytochalasin B