title: Nitric oxide synthase in chick embryo retina during development.
abstract: High levels of nitric oxide synthase were found in the early stages of developing chick embryo retina. The enzyme activity sharply decreased up to 13-day-old chick embryo retina, when the level of the last embryonic day was reached. The results show that nitric oxide is synthesized in chick embryo retina prior to synaptogenesis. The incubation of chick embryo retinas in presence of NMDA increased the synthesis of nitric oxide, thus, the appearance of nitric oxide production before the synaptogenesis in the retina as well as in the brain may be considered as signal for the development and shaping of neuronal and non-neuronal cells.
authors.affiliation: Institute of Biochemical Sciences and Clinical Biochemistry, Faculty of Medicine, University of Messina, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ientile
authors.forename: B
authors.initials: B
authors.lastname: Malecka
authors.forename: V
authors.initials: V
authors.lastname: Picciurro
authors.forename: A
authors.initials: A
authors.lastname: Naso
authors.forename: S
authors.initials: S
authors.lastname: Pedale
authors.forename: S
authors.initials: S
authors.lastname: Macaione
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002642:Chick Embryo; D016202:N-Methylaspartate / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012160:Retina / Q000187:drug effects / Q000196:embryology* / Q000201:enzymology*; D013569:Synapses / Q000378:metabolism; D013997:Time Factors
chemical_list: D009569:Nitric Oxide; D016202:N-Methylaspartate; D019001:Nitric Oxide Synthase; D002118:Calcium