title: Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient.
abstract: A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatous disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.
authors.affiliation: Istituto di Medicina Interna, University of Milano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cofrancesco
authors.forename: M A
authors.initials: MA
authors.lastname: Viviani
authors.forename: C
authors.initials: C
authors.lastname: Boschetti
authors.forename: A M
authors.initials: AM
authors.lastname: Tortorano
authors.forename: A
authors.initials: A
authors.lastname: Balzani
authors.forename: D
authors.initials: D
authors.lastname: Castagnone
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001752:Blast Crisis; D003102:Colloids; D004359:Drug Therapy, Combination; D005260:Female; D016469:Fungemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005704:Gallbladder / Q000000981:diagnostic imaging; D005847:Geotrichosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000935:Antifungal Agents; D003102:Colloids; D017964:Itraconazole; D000666:Amphotericin B