title: The use of technetium-99m hexamethylpropylene amine oxime labelled granulocytes with single-photon emission tomography imaging in the detection and follow-up of recurrence of infective endocarditis complicating transvenous endocardial pacemaker.
abstract: In this case report we present a patient with a recurrence of subacute bacterial infectious endocarditis (IE) complicating a transvenous endocardial pacemaker. Technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) labelled granulocytes were used for diagnosis and follow-up under medical treatment only, since surgical removal of the pacemaker lead was ruled out because of the general condition of the patient. Single-photon emission tomography (SPET) imaging displayed the active lesion previously suspected on echography. At the end of antibiotic therapy, SPET indicated a favourable disease outcome whereas echocardiographic abnormalities remained nearly unchanged. The medical treatment had eradicated the IE, and the patient did well for more than 1 year thereafter.
authors.affiliation: Department of Nuclear Medicine, CHU E. Herriot, Lyon, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Ramackers
authors.forename: P O
authors.initials: PO
authors.lastname: Kotzki
authors.forename: I
authors.initials: I
authors.lastname: Couret
authors.forename: P
authors.initials: P
authors.lastname: Messner-Pellenc
authors.forename: J M
authors.initials: JM
authors.lastname: Davy
authors.forename: M
authors.initials: M
authors.lastname: Rossi
mesh_terms: D000368:Aged; D004452:Echocardiography; D004698:Endocarditis, Subacute Bacterial / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D006098:Granulocytes; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D012008:Recurrence; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime