Inhibitory effect of a single local probucol administration on neointimal formation in balloon-injured rat carotid artery.
The aim of this study was to determine whether a single local probucol administration could suppress neointimal formation in balloon-injured rat carotid artery. Rats were divided into four groups; (i) rats receiving no probucol (control group); (ii) rats receiving topical application of 50 mg probucol at the time of ballooning (p-top group); (iii) rats fed chow containing 1% probucol (p-fed group; (iv) rats receiving both topical application of 50 mg probucol and chow containing 1% probucol (p-top/fed group). Although serum total cholesterol levels did not significantly differ between the control and the p-top groups at two weeks after balloon injury, the p-top group had a smaller intimal/medial ratio or intimal area than the control group (0.97 +/- 0.11 vs. 0.53 +/- 0.08 or 0.15 +/- 0.02 mm2 vs. 0.08 +/- 0.02 mm2 respectively, P < 0.01). Neointimal formation was suppressed to a similar extent in the p-fed group, in which serum total cholesterol level was approximately 40% lower than that in the control group. Thus, a single local delivery of probucol can suppress neointimal formation in balloon-injured rat carotid artery without altering serum lipid level.
Ishizaka
N
N
First Department of Internal Medicine Faculty of Medicine, of Tokyo, Japan.
Kurokawa
K
K
Taguchi
J
J
Miki
K
K
Ohno
M
M
D000287:Administration, Topical; D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D020212:Carotid Artery Injuries; D017536:Carotid Artery, Common / Q000473:pathology*; D002404:Catheterization; D002784:Cholesterol / Q000097:blood; D006965:Hyperplasia; D008297:Male; D011341:Probucol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017539:Tunica Intima / Q000473:pathology*
D000924:Anticholesteremic Agents; D002784:Cholesterol; D011341:Probucol