title: Non-ulcer dyspepsia in the long-term perspective.
abstract: OBJECTIVE
  To study the natural history of non-ulcer dyspepsia.
  
  
  METHODS
  Retrospective study on consecutive cases of non-ulcer dyspepsia diagnosed in 1980 and 1981. The long-term course was ascertained from medical records and from answers to a questionnaire completed by the patients at 10-year follow-up.
  
  
  METHODS
  Out-patients at the endoscopy unit of a county hospital.
  
  
  METHODS
  The diagnosis was based on typical symptoms of dyspepsia, a normal index endoscopy and a lack of evidence of organic disease related to the symptoms during the subsequent 12-month period. Two hundred and seventy-one patients were entered into the study. Of the 195 who received a questionnaire at 10-year follow-up, 165 (85%) responded.
  
  
  RESULTS
  The median age at inclusion was 51 years (25-75 percentiles 38-65 years), and 130 men and 141 women were included in the study. The cumulative death rate after 10 years was 18%, a value no greater than that in the general population: 8% had died of cardiovascular disease, 1.5% of gastrointestinal cancer and 3% of other malignancies. One patient had died of a perforated gastric ulcer. At 10-year follow-up, a further three patients had developed peptic ulcers (expected number 4.2), 64% had experienced dyspeptic symptoms during the preceding 12 months and 41% had been taking analgesics during the previous week. Of the symptoms listed by the patients, 30% were typical of irritable bowel syndrome.
  
  
  CONCLUSIONS
  Non-organic dyspepsia seems to be a chronic disease in most patients. The course is benign and unrelated to peptic ulcer disease.
authors.affiliation: Department of Surgery, Lund University Hospital, Sweden.
authors.forename: G H
authors.initials: GH
authors.lastname: Lindell
authors.forename: F
authors.initials: F
authors.lastname: Celebioglu
authors.forename: H O
authors.initials: HO
authors.lastname: Graffner
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D002908:Chronic Disease; D003109:Colonic Diseases, Functional / Q000150:complications; D004415:Dyspepsia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016145:Endoscopy, Digestive System; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications; D012189:Retrospective Studies; D011795:Surveys and Questionnaires