[Use of an activated chemiluminescence method for studying the pharmacologic properties of medicinal substances].
When given to non-inbred male rats during 1, 2, and 3 months, aqueous extract from the above-ground Padus Grajana maxim parts was tested for its effects on the parameters of chemiluminescence-activated rat serum. The tested agent was found to increase he rate of rapid and slow chemiluminescence flashes. The level of steady-state glow considerably declined after the agent was given for a month; however, its longer use increased the steady-state chemiluminiscence and by the end of the 3rd month it was equal to that of control animals. Whether the activated chemiluminescence technique can be used to evaluate the effect of biologically active substances on cell structures, to refine some aspects of the mechanism of action of drugs is discussed on in terms of the findings.
Nanaeva
M T
MT
Zurdinov
A Z
AZ
Sabirova
T S
TS
Atanaev
T B
TB
Kudaĭbergenova
T A
TA
D000818:Animals; D001769:Blood; D008163:Luminescent Measurements; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D010936:Plant Extracts
Ispol'zovanie metoda aktivirovannoĭ khemiliuminestsentsii pri izuchenii farmakologicheskikh svoĭstv lekarstvennykh preparatov.