title: Analysis of changes in coagulation factors after postoperative blood loss in burn and non-burn patients.
abstract: A prospective study of the postoperative kinetics of coagulation factors was undertaken in 23 burn patients and in six non-burn patients. All procedures resulted in a large volume blood loss. Fibrinogen, platelets and factors V, VIII and IX were measured serially. Burn patients returned all parameters to preoperative levels by 48 h postoperation, while non-burn patients showed a slower rate of return of platelets and factor V. This study suggests that burn patients may safely undergo re-operation at 48 h intervals for successive wound debridements if clinically necessary.
authors.affiliation: Department of Surgery, University of Iowa College of Medicine, Iowa City, USA.
authors.forename: P
authors.initials: P
authors.lastname: Chang
authors.forename: D J
authors.initials: DJ
authors.lastname: Murray
authors.forename: J D
authors.initials: JD
authors.lastname: Olson
authors.forename: B J
authors.initials: BJ
authors.lastname: Pennell
authors.forename: R W
authors.initials: RW
authors.lastname: Lewis
authors.forename: G P
authors.initials: GP
authors.lastname: Kealey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002056:Burns / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008875:Middle Aged; D010976:Platelet Count; D019106:Postoperative Hemorrhage / Q000097:blood* / Q000601:surgery; D011446:Prospective Studies; D012086:Reoperation
chemical_list: D001779:Blood Coagulation Factors