[Diazepam eliminates the anxious state induced by amputation of the vibrissae (a model for assessing anxious behavior)].
Diazepam (0.5 mg/kg) prevented reduction of motor activity of rats (both vertical and horizontal components) induced by vibrissae amputation. It is suggested that the observed decrease in motility is related to development of a pathologic reaction of anxiety. The method is recommended as a test for anxious behaviour in experiment.
Kozlovskiĭ
V L
VL
Prakh'e
I V
IV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D051381:Rats; D012683:Sensory Deprivation / Q000502:physiology; D013997:Time Factors; D014738:Vibrissae / Q000502:physiology*
D014151:Anti-Anxiety Agents; D003975:Diazepam
Diazepam snizhaet trevozhnoe sostoianie, vyzvannoe amputatsieĭ vibriss (model' otsenki trevozhnogo povedeniia).