Influence of glycyrrhizin on the evolution and respiration of Ehrlich ascites tumour cells.
It has been demonstrated that 18 alpha-glycyrrhetinic acid, 18 beta-glycyrrhetinic acid and glycyrrhizin effectively inhibit the inception and growth of skin tumours. Moreover, glycyrrhizin and its aglycone act on the growth and differentiation of mouse melanoma cells in culture. In this study we investigated the effect of glycyrrhizin, 18 alpha- and 18 beta-glycyrrhetinic acids on the evolution of Ehrlich ascites tumour in mice. A prolonged glycyrrhizin treatment proved to be effective in modifying the animals' survival pattern.
Rossi
T
T
Department of Pharmaceutical Sciences, University of Modena, Italy.
Galatulas
I
I
Bossa
R
R
Tampieri
A
A
Tartoni
P
P
Baggio
G
G
Ruberto
A I
AI
Castelli
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D019069:Cell Respiration / Q000187:drug effects; D005260:Female; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D006170:Gum Arabic / Q000494:pharmacology; D051379:Mice
D000970:Antineoplastic Agents; D019695:Glycyrrhizic Acid; D006170:Gum Arabic; D006034:Glycyrrhetinic Acid