The role of chromosome translocations in T cell acute leukemia.
A variety of unique chromosome translocations are found in the malignant cells of patients with T cell acute lymphoblastic leukemia (T-ALL). Molecular analysis of these translocations has implicated nine different proto-oncogenes in the pathogenesis of T-ALL. Despite the apparent genetic complexity of this disease, recent studies have uncovered a common pathway of T-ALL development that involves two distinct families of transcription factors.
Hwang
L Y
LY
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235-9140, USA.
Baer
R J
RJ
D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000378:metabolism; D011519:Proto-Oncogenes; D014157:Transcription Factors / Q000378:metabolism; D014178:Translocation, Genetic
D014157:Transcription Factors