Simulation of chronic mitral regurgitation.
In mitral regurgitation the left ventricle enlarges in order to increase its stroke volume because of the regurgitation through the mitral valve. The amount of this volume increase, and of the consequent increase in left ventricular mass, its dependent upon the amount of the regurgitant volume, but many other factors come into play, such as left ventricular pumping capability (contractility), the level of peripheral pressure, resistance and compliance of the arterial tree. The aim of this study is to predict the final left ventricular volumes and mass given the amount of mitral regurgitation. The predicted results are compared with actual data in real patients. In most cases prediction is fairly good; some discrepancies can be interpreted as an index of advanced decompensation.
Razzolini
R
R
Department of Hemodynamics, University of Padova Medical School, Italy.
Viena
P
P
Degan
F
F
Chioin
R
R
Carasi
M
M
Vaccari
D
D
Vendrametto
F
F
Dalla-Volta
S
S
D002302:Cardiac Output; D002908:Chronic Disease; D003198:Computer Simulation; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D016018:Least-Squares Analysis; D016014:Linear Models; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D013318:Stroke Volume