A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.
A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
Meerabux
J
J
Department of Medical Oncology, Imperial Cancer Research Fund, St. Bartholomew's Hospital, London, United Kingdom.
Yaspo
M L
ML
Roebroek
A J
AJ
Van de Ven
W J
WJ
Lister
T A
TA
Young
B D
BD
D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D003001:Cloning, Molecular; D015321:Gene Rearrangement; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D012697:Serine Endopeptidases / Q000235:genetics*; D013381:Subtilisins; D014178:Translocation, Genetic
C099101:PCSK7 protein, human; D012697:Serine Endopeptidases; D013381:Subtilisins