Chronobiology and chronotherapy of asthma.
There is no doubt that many pathophysiologic conditions change over a 24-hour period and thus therapy needs to be directed at these changes. In particular, asthma has been one of the better-studied disease processes in regard to circadian changes in pathophysiology. As we continue to learn more about circadian changes, better approaches to treating the disease with the same medications will emerge. It should be remembered that many asthmatics do not perceive their degree of bronchoconstriction. This was brought forth in Turner-Warwick's epidemiologic study in that less than one half of the asthmatic individuals who had problems with their asthma every night describe their asthma as being severe. The majority stated they either had mild or moderate asthma. Therefore, it is important that we use objective criteria such as peak flow meters in determining an individual patient's day-to-night changes in lung function. Then, any therapeutic intervention can be objectively determined at home with both the patient and physician gaining knowledge about the ongoing asthmatic process.
Pincus
D J
DJ
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.
Beam
W R
WR
Martin
R J
RJ
D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D006801:Humans