Peroxidase activation of 4-hydroxytamoxifen to cause DNA damage in vitro.
Davies
A M
AM
MRC Toxicology Unit, University of Leicester, U.K.
Malone
M E
ME
White
I N
IN
D001711:Biotransformation; D004249:DNA Damage; D004578:Electron Spin Resonance Spectroscopy; D004965:Estrogen Antagonists / Q000378:metabolism* / Q000493:pharmacokinetics / Q000633:toxicity*; D005609:Free Radicals / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000378:metabolism; D066298:In Vitro Techniques; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity
D004965:Estrogen Antagonists; D005609:Free Radicals; D013629:Tamoxifen; C016601:afimoxifene; D006735:Horseradish Peroxidase; C062262:4-hydroxytoremifene