title: Infantile osteopetrosis; bone marrow transplantation from a cousin donor.
abstract: The successful correction of infantile osteopetrosis in an Asian child by bone marrow transplantation (BMT) from an HLA-A,B matched cousin donor is reported. Retrospective HLA molecular analysis revealed that patient and donor were incompatible for HLA-DPB1. Donor type cells detected in the patient after transplantation indicate successful engraftment. The patient is currently alive and well.
authors.affiliation: Immunogenetics Laboratory, St Marys Hospital, Manchester.
authors.forename: G M
authors.initials: GM
authors.lastname: Taylor
authors.forename: S P
authors.initials: SP
authors.lastname: Dearden
authors.forename: A M
authors.initials: AM
authors.lastname: Will
authors.forename: D I
authors.initials: DI
authors.lastname: Evans
authors.forename: R F
authors.initials: RF
authors.lastname: Stevens
authors.forename: S
authors.initials: S
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Super
authors.forename: G
authors.initials: G
authors.lastname: Morrell
authors.forename: W D
authors.initials: WD
authors.lastname: Fergusson
authors.forename: I H
authors.initials: IH
authors.lastname: Brown
mesh_terms: D016026:Bone Marrow Transplantation; D005260:Female; D006680:HLA Antigens; D015235:HLA-B Antigens; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; D006648:Histocompatibility; D006801:Humans; D007223:Infant; D010022:Osteopetrosis / Q000235:genetics / Q000276:immunology / Q000601:surgery*; D010375:Pedigree
chemical_list: D006680:HLA Antigens; D015235:HLA-B Antigens; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen