Effect of inhaled nedocromil sodium therapy on blood gas changes in children challenged with ultrasonically nebulized distilled water. A comparison of 8 mg versus 16 mg daily dose.
Changes in time course of blood partial pressures of oxygen (PtcO2) and carbon dioxide (PtcCO2) before, during and after challenge with ultrasonically nebulized distilled water (UNDW) were evaluated in 22 children with mild asthma in basal conditions, and after 8 weeks of therapy with inhaled nedocromil sodium at a daily dosage of 8 or 16 mg. PtcO2 and PtcCO2 were followed using transcutaneous O2 and CO2 monitoring system. All asthmatic subjects presented a significant decrease in PtcO2 and/or PtcCO2 (> 20% basal value) during or after challenge. After therapy, the decrease in PtcO2 and PtcCO2 was normalized in the group treated with 16 mg/day, whereas only a partial yet significant reduction in the decrease of O2 and CO2 was observed in the group assuming 8 mg/-day. These data indicate that inhaled nedocromil is effective in treating bronchial hyperresponsiveness in childhood and that the dose required to achieve this effect is of 16 mg/day.
Oggiano
N
N
Clinica Pediatrica, Università degli Studi, Ancona.
Kantar
A
A
Bruni
S
S
Cutrona
F M
FM
Fabbrizi
E
E
Piccinini
R
R
De Cristofaro
L
L
Lanfranchi
E
E
Giorgi
P L
PL
D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D002245:Carbon Dioxide / Q000097:blood*; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D017835:Nedocromil / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood*; D013997:Time Factors; D014465:Ultrasonics; D014867:Water
D018927:Anti-Asthmatic Agents; D014867:Water; D017835:Nedocromil; D002245:Carbon Dioxide; D010100:Oxygen