Arsenite, but not cadmium, induces ornithine decarboxylase and heme oxygenase activity in rat liver: relevance to arsenic carcinogenesis.
Sodium arsenite and cadmium chloride, were administered orally to adult female rats at 21 and 4 h prior to sacrifice. Liver, lung, skin and urinary bladder were the tissues studied. DNA damage, cytochrome P450, glutathione content (GSH), ornithine decarboxylase (ODC), serum alanine aminotransferase and heme oxygenase activity were measured. Sodium arsenite increased rat hepatic ODC activity at 1.6 and 24.6 mg/kg and hepatic heme oxygenase activity at 8.2 and 24.6 mg/kg, but did not cause any DNA damage. Cadmium chloride did not affect any of the six parameters tested. These findings suggest that sodium arsenite may be a promoter rather than an initiator of carcinogenesis.
Brown
J L
JL
Environmental Carcinogenesis Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Kitchin
K T
KT
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D018053:Arsenites / Q000633:toxicity*; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002273:Carcinogens / Q000633:toxicity*; D002712:Chlorides / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017670:Sodium Compounds / Q000633:toxicity*
D018053:Arsenites; D002273:Carcinogens; D002712:Chlorides; D017670:Sodium Compounds; D002104:Cadmium; C017947:sodium arsenite; D003577:Cytochrome P-450 Enzyme System; D006419:Heme Oxygenase (Decyclizing); D000410:Alanine Transaminase; D009955:Ornithine Decarboxylase; D005978:Glutathione; D019256:Cadmium Chloride