title: Approaches to short-acting neuromuscular blocking agents: nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters.
abstract: Nonsymmetrical bisquaternary mono- and diesters combining the potency-enhancing properties of the (1R)-laudanosinium group with a second unhindered quaternary ammonium moiety have been studied as a means of promoting short action with high-potency neuromuscular block. Atracurium-related nonsymmetrical diesters showed high potency, freedom from vagal blockade at neuromuscular blocking doses, and short action. Nonsymmetrical monoesters were short acting but showed varying degrees of vagal block.
authors.affiliation: Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, Scotland.
authors.forename: N C
authors.initials: NC
authors.lastname: Dhar
authors.forename: R B
authors.initials: RB
authors.lastname: Maehr
authors.forename: L A
authors.initials: LA
authors.lastname: Masterson
authors.forename: J M
authors.initials: JM
authors.lastname: Midgley
authors.forename: J B
authors.initials: JB
authors.lastname: Stenlake
authors.forename: W B
authors.initials: WB
authors.lastname: Wastila
mesh_terms: D000818:Animals; D002415:Cats; D002855:Chromatography, Thin Layer; D004952:Esters; D006868:Hydrolysis; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009466:Neuromuscular Blocking Agents / Q000737:chemistry / Q000494:pharmacology*; D011806:Quinolinium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects
chemical_list: D004952:Esters; D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D011806:Quinolinium Compounds; C001522:laudanosine