Heparin-induced thrombocytopenia: cross-reactivity between standard heparin, low molecular weight heparin, dalteparin (Fragmin) and heparinoid, danaparoid (Orgaran).
The incidence of cross-reactivity between unfractionated heparin and LMWH, fragmin, in patients with HIT is significantly lower (6/15, 40%) than hitherto reported in the literature. 7/9 patients with a negative cross-reactivity test were treated with dalteparin sodium (Fragmin) without any untoward events.
Ramakrishna
R
R
Department of Clinical Haematology, St George Hospital, Kogarah, N.S.W., Australia.
Manoharan
A
A
Kwan
Y L
YL
Kyle
P W
PW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002809:Chondroitin Sulfates / Q000009:adverse effects; D017985:Dalteparin / Q000627:therapeutic use*; D003871:Dermatan Sulfate / Q000009:adverse effects; D004347:Drug Interactions; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006496:Heparinoids / Q000009:adverse effects; D006497:Heparan Sulfate / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced*
D002809:Chondroitin Sulfates; D017985:Dalteparin; D003871:Dermatan Sulfate; D006493:Heparin; D006495:Heparin, Low-Molecular-Weight; D006496:Heparinoids; D006497:Heparan Sulfate; C035838:danaparoid