title: Primary invasive vaginal carcinoma treated with radiotherapy: analysis of prognostic factors.
abstract: Between 1965 and 1988, 125 patients with primary invasive vaginal carcinoma were treated with radiation therapy at the Center of Oncology in Kraków. Twenty-two superficial stage I patients received radium or cesium intracavitary radiation alone. The remaining 11 patients with stage I disease whose lesions were either large or thick and 77 patients with stages II and III were treated with a combination of external irradiation followed by intracavitary brachytherapy. Fifteen patients with stage IVA received external irradiation only. Five-year NED survival was achieved in 42.4% of patients. In the Cox multivariate analysis three variable were independently related to beneficial survival: grade G1 + G2, stage I + II, and age below 60 years. Of 66 patients who died of vaginal cancer, locoregional failure was found in 51 (77.3%), locoregional and distant in 5 (7.6%), and distant only in 10 (15.1%) patients. Late radiation morbidity occurred in 16 (12.8%) patients.
authors.affiliation: Department of Gynecologic Oncology, Maria Skłodowska-Curie Memorial Institute, Kraków, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Urbański
authors.forename: Z
authors.initials: Z
authors.lastname: Kojs
authors.forename: M
authors.initials: M
authors.lastname: Reinfuss
authors.forename: W
authors.initials: W
authors.lastname: Fabisiak
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects; D016879:Salvage Therapy; D014625:Vaginal Neoplasms / Q000473:pathology / Q000532:radiotherapy*