title: Parental exposure to hydrocarbons in Prader-Willi syndrome.
abstract: The purpose of this study was to ascertain whether parental age and parental pre-conceptional exposure to various agents differentiated children with Prader-Willi syndrome (PWS) from obese children without PWS. Two groups of patients under 25 years of age were studied, 15 persons with PWS, and 13 with PWS-like symptoms. In the PWS group deletions were detected on chromosome 15q11-q13 and parents were older. The parents' occupational and recreational exposure to environmental toxins was recorded and correlated to the clinical diagnosis, genetics and behaviour characteristics. Paternal exposure to gasoline/petrol was significantly higher in the PWS group and is suggested as a possible important factor in the aetiology of PWS.
authors.affiliation: Department of Clinical Neuroscience, Annedalskliniken, Göteborg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Akefeldt
authors.forename: M
authors.initials: M
authors.lastname: Anvret
authors.forename: U
authors.initials: U
authors.lastname: Grandell
authors.forename: R
authors.initials: R
authors.lastname: Nordlinder
authors.forename: C
authors.initials: C
authors.lastname: Gillberg
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002884:Chromosomes, Human, Pair 15; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects*; D007223:Infant; D008297:Male; D010290:Parents; D011218:Prader-Willi Syndrome / Q000235:genetics*
chemical_list: D006838:Hydrocarbons