Effects of PF1022A on adult Angiostrongylus cantonensis in the pulmonary arteries and larvae migrating into the central nervous system of rats.
We examined the effects of PF1022A, newly developing in Japan, on adult Angiostrongylus cantonensis in the pulmonary arteries of rats. Following five and ten successive oral doses at 10 mg/kg per day, the first-stage larvae in rat faeces disappeared completely at 2 weeks after treatment. The treatment completely killed the female worms, but not the male worms. However, numbers of male worms were also decreased after the administration of either five successive oral doses at 10 mg/kg per day for four courses or five successive intraperitoneal doses at 0.5 mg/kg per day. Next, we examined the effects of PF1022A on larval A. cantonensis migrating into the central nervous system (CNS) of rats. Following five successive oral doses at 5 or 10 mg/kg per day and five successive intraperitoneal doses at 0.5 mg/kg per day, lesser killing effects were observed on male as well as female worms. On the basis of these results it is apparent that PF1022A will become a promising anthelmintic available as treatment for tissue-dwelling as well as intestinal nematodes.
Kachi
S
S
Department of Parasitology, Hamamatsu University School of Medicine, Japan.
Ishih
A
A
Terada
M
M
D000284:Administration, Oral; D017185:Angiostrongylus cantonensis / Q000187:drug effects* / Q000472:pathogenicity; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D002490:Central Nervous System / Q000469:parasitology*; D047630:Depsipeptides; D005260:Female; D007274:Injections, Intraperitoneal; D007814:Larva; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000469:parasitology; D051381:Rats; D017208:Rats, Wistar; D017206:Strongylida Infections / Q000188:drug therapy* / Q000469:parasitology
D000969:Antinematodal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C075544:PF 1022A