title: Molecular inactivation. Spatially and temporally defined molecular knockouts.
abstract: Most monoclonal antibodies do not functionally inactivate the antigen they recognize. This limitation can be overcome by localized chromophore-assisted laser inactivation (CALI) of specific antibody-linked proteins.
authors.affiliation: Abteilung Physikalische Biologie, Max-Planck-Institute für Entwicklungsbiologie, Tübingen, Germany.
authors.forename: B K
authors.initials: BK
authors.lastname: Müller
authors.forename: F
authors.initials: F
authors.lastname: Bonhoeffer
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000276:immunology; D000941:Antigens / Q000737:chemistry* / Q000276:immunology; D004396:Coloring Agents; D007834:Lasers; D011489:Protein Denaturation
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D004396:Coloring Agents