Exclusion from proximal 11q of a common gene with megaphenic effect on atopy.
We have typed three markers on proximal 11q in 131 random families with three or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2-locus disease model, we performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene.
Watson
M
M
Human Genetics Centre University of Southampton, Princess Ann Hospital.
Lawrence
S
S
Collins
A
A
Beasley
R
R
Doull
I
I
Begishvili
B
B
Lampe
F
F
Holgate
S T
ST
Morton
N E
NE
D000483:Alleles; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D007962:Leukocytes; D008126:Lod Score; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D006005:Phosphorylases / Q000235:genetics; D017455:Receptors, IgE / Q000235:genetics*; D006113:United Kingdom
D005819:Genetic Markers; D017455:Receptors, IgE; D006005:Phosphorylases