Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients.
OBJECTIVE
Low concentrations of alpha tocopherol are claimed to be associated with an increased prevalence of coronary heart disease. This study was undertaken to see whether measurements of serum tocopherol concentrations can contribute to discrimination between subjects with and without coronary heart disease.


METHODS
All patients had been referred to the department of cardiology of the University Hospital in Uppsala, Sweden.


METHODS
Male patients (n = 69) below 60 years of age with coronary heart disease (CHD) and healthy age-matched reference subjects (n = 138) were compared.


RESULTS
Lipid-corrected alpha tocopherol concentrations did not differ significantly between the groups, but the CHD group had a lower mean concentration of gamma tocopherol and a higher alpha/gamma ratio. In a stepwise logistic regression analysis, the LDL/HDL ratio was the best independent discriminator between the groups, followed by the proportion of palmitic acid in the cholesterol esters and the alpha/gamma tocopherol ratio.


CONCLUSIONS
The lower gamma tocopherol concentration and the high ratio between alpha and gamma tocopherol in the CHD group indicate a difference in antioxidative status between CHD patients and healthy subjects. The lipid-lowering treatment of these CHD patients is far from optimal.
Ohrvall
M
M
Department of Geriatrics, University of Uppsala, Sweden.
Sundlöf
G
G
Vessby
B
B
D000328:Adult; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000097:blood; D011795:Surveys and Questionnaires; D014810:Vitamin E / Q000097:blood*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D010169:Palmitic Acids; D014810:Vitamin E; D019308:Palmitic Acid