In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum.
Experiments were carried out to compare the sensitivity of Ancylostoma ceylanicum and Necator americanus to ivermectin (IVM) and pyrantel in vitro. Loss of motility and inhibition of ingestion by IVM were compared and A. ceylanicum was found to be approximately 40-50 times more sensitive to IVM than N. americanus. Both species showed a similar sensitivity to pyrantel. Uptake of [3H]IVM across the cuticle was compared and shown to be unlikely to account for the differences in sensitivity to IVM between the two species.
Richards
J C
JC
Department of Life Science, University of Nottingham, University Park, U.K.
Behnke
J M
JM
Duce
I R
IR
D000722:Ancylostoma / Q000187:drug effects*; D000818:Animals; D000969:Antinematodal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D006224:Cricetinae; D004347:Drug Interactions; D005260:Female; D007444:Inulin / Q000493:pharmacokinetics; D007559:Ivermectin / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D009331:Necator / Q000187:drug effects*; D011715:Pyrantel / Q000494:pharmacology
D000969:Antinematodal Agents; D011715:Pyrantel; D007559:Ivermectin; D007444:Inulin