The effect of temazepam on respiration in elderly insomniacs with mild sleep apnea.
This study evaluated the respiratory effect of temazepam in elderly subjects (mean age 65 +/- 3.8 years), with mild sleep apnea. The 15 subjects of this report were enrolled in a larger randomized trial comparing pharmacological and behavioral treatments for insomnia. Seven subjects received temazepam 15-30 mg/day either alone or in combination with behavior therapy, and eight subjects received placebo or behavior therapy. The mean baseline respiratory disturbance index (RDI) was 9.2 +/- 2.8 for the nondrug and 8.8 +/- 5.3 for the temazepam group. There were no significant time, group or interaction effects. There was no increase in the RDI in elderly subjects with mild respiratory apnea receiving 15-30 mg of temazepam.
Camacho
M E
ME
Division of Geriatric Medicine, Medical College of Virginia/Virginia Commonwealth University, USA.
Morin
C M
CM
D000368:Aged; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use*; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects*; D012891:Sleep Apnea Syndromes / Q000188:drug therapy*; D013693:Temazepam / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D006993:Hypnotics and Sedatives; D013693:Temazepam