title: MRI in thorotrastosis.
abstract: Magnetic resonance imaging (MRI) and computed tomography (CT) were performed in four patients with thorotrastosis. On CT scan, Thorotrast (thorium oxide) deposition was shown as high-density areas in the liver and spleen and the abdominal lymph nodes. These deposits were not found on MRIs. Splenic volume was significantly small due to atrophy. The contrast-noise ratio in the spleen on T1-weighted images was significantly lower. Thorotrast deposition does not affect MRI appearance; therefore it may be useful for the early detection of malignant tumors as a complication of thorotrastosis.
authors.affiliation: Second Department of Medicine, Kurume University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: H
authors.initials: H
authors.lastname: Ijyuin
authors.forename: S
authors.initials: S
authors.lastname: Itano
authors.forename: H
authors.initials: H
authors.lastname: Noguchi
authors.forename: K
authors.initials: K
authors.lastname: Sakata
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
authors.forename: T
authors.initials: T
authors.lastname: Aritaka
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Tanikawa
mesh_terms: D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D003287:Contrast Media / Q000009:adverse effects* / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D013154:Spleen / Q000473:pathology; D013158:Splenic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D013911:Thorium Dioxide / Q000009:adverse effects* / Q000493:pharmacokinetics; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D013911:Thorium Dioxide