Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.
The effect of hyperbaric oxygen (HBO) as an immunosuppressive agent was evaluated by using a highly immunogenic skin allograft mouse model. Immune-histoincompatible female C57BL/6 and BALB/c mice (N = 30) were randomly assigned to three groups receiving no treatment (control group), low dose HBO treatment (two treatments once a week), and intermediate HBO treatment (two treatments 3 times/wk) 1 wk before and 2 wk after transplantation of a 1.5 x 2 cm full thickness skin allograft from the back. Rejection was observed a Day 7 and was completed 14 days after surgery in controls. Low dose and intermediate HBO treatment delayed skin allograft rejection, which was histologically confirmed.
Erdmann
D
D
Department of Surgery, Southern Illinois University-School of Medicine, Springfield 63702-9230, USA.
Roth
A C
AC
Hussmann
J
J
Lyons
S F
SF
Mody
N J
NJ
Kucan
J O
JO
Russell
R C
RC
D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006931:Hyperbaric Oxygenation; D007121:Immunocompetence; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011897:Random Allocation; D013524:Surgical Flaps