title: Evaluation of a novel synthetic material for closure of large abdominal wall defects.
abstract: BACKGROUND
  This study was undertaken to compare the efficacy of a novel synthetic material (TMS-1) with polytetrafluoroethylene, polypropylene, and primary closure of experimentally fashioned clean and contaminated abdominal wounds.
  
  
  METHODS
  One square centimeter full-thickness abdominal wall defects were created in each of the four abdominal quadrants of anesthetized rats (n = 6). Patches of polytetrafluoroethylene, polypropylene, and a polyurethane-polypropylene composite material (TMS-1) were used to repair three of these defects; the fourth was primarily closed. A second group of rats (n = 9) underwent the same operative protocol; however, peritonitis was induced at the time of operation by using the fecal inoculation technique. Animals were killed 2 to 3 weeks later, and surface area and severity of formed adhesions were assessed.
  
  
  RESULTS
  By all methods of assessment, primary closure proved significantly superior to all other methods of closure in clean and contaminated conditions. The three synthetic materials were equally matched for surface area involved in adhesion formation. When compared with the other synthetic materials, TMS-1 was associated with significantly milder adhesions in uninfected (p < 0.002) and in infected (p < 0.002) conditions.
  
  
  CONCLUSIONS
  The clear superiority of TMS-1 over other nonabsorbable synthetic materials shown in this pilot study warrants further investigation relative to its use to close large abdominal wall defects.
authors.affiliation: Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: S
authors.initials: S
authors.lastname: Aliabadi-Wahle
authors.forename: E U
authors.initials: EU
authors.lastname: Choe
authors.forename: J
authors.initials: J
authors.lastname: Jacob-LaBarre
authors.forename: L M
authors.initials: LM
authors.lastname: Flint
authors.forename: J J
authors.initials: JJ
authors.lastname: Ferrara
mesh_terms: D000009:Abdominal Muscles / Q000293:injuries* / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D008297:Male; D008855:Microscopy, Electron, Scanning; D011126:Polypropylenes / Q000009:adverse effects; D011138:Polytetrafluoroethylene / Q000009:adverse effects; D011140:Polyurethanes / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000209:etiology; D014946:Wound Infection
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes; D011140:Polyurethanes; C097985:polyurethane-polypropylene composite; D011138:Polytetrafluoroethylene