[Clastogenic activity of dietary sugar substitutes].
The present paper describes the possible clastogenic activity of the following synthetic sugar substitutes, such as cyclamate in daily doses of 11 and 110 mg/kg, saccharin, 5 and 50 mg/kg, acesulfam, 15 and 150 mg/kg, sucralose, 15 and 150 mg/kg, aspartame, 40 and 400 mg/kg, orally given to C57Bl/6 mice during 5 days. No clastogenic activity was found in the compounds tested.
Durnev
A D
AD
Oreshchenko
A V
AV
Kulakova
A V
AV
Beresten'
N F
NF
Seredenin
S B
SB
D000818:Animals; D002869:Chromosome Aberrations; D004032:Diet; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D013549:Sweetening Agents / Q000633:toxicity*
D013549:Sweetening Agents
Issledovanie klastogennoĭ aktivnosti pishchevykh sakharozameniteleĭ.