title: Effect of partial pressure on solubility of isoflurane in blood.
abstract: The effect of partial pressure of isoflurane on its solubility in blood of different haematocrit was determined at different isoflurane partial pressures, using a syringe--flask method and gas chromatography with blood from one donor. The solubility of isoflurane decreased with increasing blood haematocrit (39.5%, 51.9% and 61.9%) and isoflurane partial pressure from 1 MAC to 4 MAC. The solubility in 50% and 60% haematocrit blood at 2, 3 and 4 MAC was significantly different from the solubility in normal blood at 1 MAC (P < 0.05). We conclude that the solution of isoflurane in blood (especially in high haematocrit blood) does not obey Henry's law.
authors.affiliation: Institute for Anaesthesiology and Intensive Care, University Hospital, Bern, Switzerland.
authors.forename: G M
authors.initials: GM
authors.lastname: Xie
authors.forename: R
authors.initials: R
authors.lastname: Lauber
authors.forename: A M
authors.initials: AM
authors.lastname: Zbinden
mesh_terms: D000328:Adult; D002849:Chromatography, Gas; D006400:Hematocrit; D006801:Humans; D007530:Isoflurane / Q000097:blood*; D008297:Male; D010313:Partial Pressure; D012995:Solubility
chemical_list: D007530:Isoflurane