title: [Bioavailability and pharmacodynamics of various forms of synthetic beta-carotene in volunteers].
abstract: The biological availability of artificial beta-carotene as a water-soluble versus oily formulation based on cyclodextrin (Cyclocar tablets) was studied on volunteers given a single dose of 25 mg. The concentrations of beta-carotene and major carotenoids were measured in the blood serum during the experiment by high performance liquid chromatography. The maximum content of beta-carotene in the serum was attained 24-30 and 30-48 hrs after oily formulations and Cyclocar and were 48.0 +/- 7.7 and 28.1 +/- 3.6 mg/dl, respectively. The rate of beta-carotene utilization from Cyclocar was 2.2 times less than that from the oil paste. Besides, beta-carotene absorbed from these oily drugs retained in the blood serum for longer period than that form Cyclocar.
authors.forename: L M
authors.initials: LM
authors.lastname: Iakushina
authors.forename: E A
authors.initials: EA
authors.lastname: Malakhova
authors.forename: T N
authors.initials: TN
authors.lastname: Shkarina
authors.forename: A A
authors.initials: AA
authors.lastname: Poznanskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Spirichev
mesh_terms: D000328:Adult; D000368:Aged; D001682:Biological Availability; D002338:Carotenoids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004304:Dosage Forms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D019207:beta Carotene
chemical_list: D004304:Dosage Forms; D019207:beta Carotene; D002338:Carotenoids
vernacular_title: Izuchenie biodostupnosti i farmakodinamiki razlichnykh form sinteticheskogo beta-karotina na dobrovol'tsakh.