Aminoglycoside pharmacokinetics and -dynamics: a nonlinear approach.
A model which correctly describes the pharmacokinetic-pharmacodynamic relationship is necessary to perform a rational pharmacotherapy. This model could predict the effects under variable conditions. The prediction will provide a basis for adapting therapy to individuals. A nonlinear model should be most appropriate for describing drug effects. A new model, containing nonlinear pharmacokinetics and pharmacodynamics, is presented to describe effects of aminoglycosides on bacterial growth and accumulation in kidney tissue.
Czock
D
D
Free University, University Hospital Benjamin Franklin, Berlin, Germany.
Giehl
M
M
D000583:Amikacin / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics; D006207:Half-Life; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008962:Models, Theoretical; D011237:Predictive Value of Tests; D051381:Rats
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000583:Amikacin