Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety.
Dickson
J K
JK
Bristol-Myers Sqibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA.
Biller
S A
SA
Magnin
D R
DR
Petrillo
E W
EW
Hillyer
J W
JW
Hsieh
D C
DC
Lan
S J
SJ
Rinehart
J K
JK
Gregg
R E
RE
Harrity
T W
TW
Jolibois
K G
KG
Kalinowski
S S
SS
Kunselman
L K
LK
Mookhtiar
K A
KA
Ciosek
C P
CP
D000284:Administration, Oral; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D006168:Guinea Pigs; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D000960:Hypolipidemic Agents; D011355:Prodrugs; D013451:Sulfonic Acids; D013186:Farnesyl-Diphosphate Farnesyltransferase