Basic study to develop the undulation pump for practical use: antithrombogenicity, hemolysis, and flow patterns inside the pump.
The undulation pump (formerly called the precessional displacement pump) is a continuous flow displacement-type blood pump that is being developed as an implantable total artificial heart. A new undulation pump was developed for chronic use and was examined with animal experiment and flow visualization studies. In the animal experiment using a left ventricular bypass in goats, severe hemolysis occurred. After driving for 12 h, thrombus formation inside the pump was found. In the flow visualization studies, the flow pattern showed that the flow inside the pump was a very complicated turbulent flow. Improvement of hemolysis and thrombus formation is important to realize implantable total artificial hearts using undulation pumps.
Abe
Y
Y
Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.
Chinzei
T
T
Isoyama
T
T
Ono
T
T
Mabuchi
K
K
Imanishi
K
K
Kouno
A
A
Atsumi
K
K
Fujimasa
I
I
Imachi
K
K
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D004867:Equipment Design; D006041:Goats; D018611:Heart Bypass, Left; D006354:Heart, Artificial / Q000592:standards*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis / Q000502:physiology*; D006358:Hot Temperature; D013927:Thrombosis / Q000517:prevention & control*; D014741:Video Recording
D006454:Hemoglobins