Effects of misoprostol on circulating HDL-cholesterol, total cholesterol, triglycerides and their relationship with hepatic microsomal function.
The effects of misoprostol (cytotec, SC29333) on circulating lipoproteins and liver microsomal enzyme activity were studied. Misoprostol increased serum levels of high density lipoprotein-cholesterol and decreased total cholesterol and triglycerides. The high density lipoprotein-cholesterol/total cholesterol ratio increased by 54.8%. In parallel, misoprostol significantly altered enzyme hepatic activity. Liver microsomal cytochromes P450 and b5 were significantly increased in correlation with enhanced liver aminopyrine N-demethylase and antipyrine hydroxylase activities, suggesting a liver induction effect of misoprostol. Other observations such as increased liver weight and glycogen and increased plasma albumin and glucose in rats receiving misoprostol support this evidence.
Godinho
A F
AF
Department of Physiological Sciences, Faculty of Medicine of Marilia, São Paulo, Brazil.
Silva
M A
MA
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D015786:Cytochromes b5 / Q000187:drug effects / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D016595:Misoprostol / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D008076:Cholesterol, HDL; D012709:Serum Albumin; D014280:Triglycerides; D016595:Misoprostol; D006003:Glycogen; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D000633:Aminopyrine N-Demethylase