Relevance of body weight to apolipoprotein levels in Australian children.
OBJECTIVE
To assess weight and apolipoprotein profiles in a representative sample of primary school children.


METHODS
1543 children (936 girls and 607 boys) aged 6-11 years from schools in the Eastern Sydney Area Health Service region in 1994.


METHODS
We measured body mass index (BMI) and capillary blood apolipoprotein (apo) B and A-I levels (the carrier proteins for low and high density lipoprotein cholesterol, respectively) as well as lipoprotein (Lp) (a). We related BMI levels to those documented in the 1985 Australian Council on Health, Physical Education and Recreation (ACHPER) survey of school children.


RESULTS
Compared with the ACHPER distribution, BMI was increased in the boys but not in the girls; 16.8% of boys were above the 90th percentile of the ACHPER distribution (P = 0.003) and only 6.5% were below the 10th percentile (P = 0.046). There were 45 boys (7.4%) and 53 girls (5.7%) with BMIs above the 95th percentile who were, by definition, obese. They had highly significant increases in apo B (P = 0.003) and apo B: apo A-I ratio (P = 0.0001) compared with children in the normal BMI range (10th-90th percentiles); and 20% of the population, including the obese group, also had Lp(a) levels greater than 300 mg/L. The results in children aged 10 and 11 years were not different from those of the whole group, consistent with an absence of possible confounding effects due to early puberty or smoking.


CONCLUSIONS
There was an increase in weight relative to height in boys aged 6-11 years in eastern Sydney, compared with the 1985 ACHPER survey. In both boys and girls with the highest BMI category, levels of apo B and the apo B: apo A-I ratio were significantly increased. As these apolipoprotein changes are correlated closely with early onset atherogenesis and are correctable, their identification offers prospects for prevention.
Wilcken
D E
DE
Department of Cardiovascular Medicine, Prince Henry Hospital, Little Bay, Sydney, NSW.
Lynch
J F
JF
Marshall
M D
MD
Scott
R L
RL
Wang
X L
XL
D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009517:New South Wales; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D012307:Risk Factors
D001053:Apolipoproteins; D001054:Apolipoproteins A; D001055:Apolipoproteins B