title: Oxygen metabolism in animals with total artificial hearts.
abstract: The relationship between indices of oxygen metabolism has been widely used in clinical practice to evaluate the adequacy of tissue perfusion, to predict the outcome of the critically ill patient, and to evaluate the effectiveness of therapies. This study quantitated and correlated the relationship between oxygen delivery (DO2), oxygen consumption (VO2), and oxygen extraction rate (EO2) in 14 animals with total artificial hearts (TAH) to investigate the oxygen metabolism in animals with TAH during different physiologic and pathologic conditions. These 14 animals were subdivided into healthy, critical, and exercise groups. There was a physiologic dependence of DO2 to VO2 in animals in the healthy and exercise groups, whereas a pathologic dependence of VO2 to DO2 appeared to occur in animals in the critical group. Reduced or inadequate VO2 leads to organ dysfunction, shock syndrome, multiple organ failure, and finally, mortality. Providing a higher level of DO2 by restoring circulating blood volume, increasing cardiac output, raising hematocrit levels, and improving pulmonary function to achieve a higher level of oxygen extract efficiency and oxygen consumption in animals with TAH that are in a critical condition might be helpful for the treatment of complications and result in decreasing mortality. Using the relationship between indices of oxygen metabolism as a physiologic modifier for TAH control algorithms also might improve the physiologic performance and quality of life of TAH recipients.
authors.affiliation: Artificial Heart Research Laboratory, University of Utah, Salt Lake City 84103-1414, USA.
authors.forename: B Y
authors.initials: BY
authors.lastname: Chiang
authors.forename: G M
authors.initials: GM
authors.lastname: Pantalos
authors.forename: G L
authors.initials: GL
authors.lastname: Burns
authors.forename: J W
authors.initials: JW
authors.lastname: Long
authors.forename: P S
authors.initials: PS
authors.lastname: Khanwilkar
authors.forename: S D
authors.initials: SD
authors.lastname: Everett
authors.forename: S F
authors.initials: SF
authors.lastname: Mohammad
authors.forename: D B
authors.initials: DB
authors.lastname: Olsen
mesh_terms: D000818:Animals; D002302:Cardiac Output; D002417:Cattle; D016638:Critical Illness; D005069:Evaluation Studies as Topic; D006354:Heart, Artificial; D006439:Hemodynamics; D006706:Homeostasis; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D005082:Physical Exertion / Q000502:physiology
chemical_list: D010100:Oxygen