Porcine TNF: a review.
One of the classical animal model systems in the study of important cardiovascular diseases, such as septic shock is that of swine. Important mediators of such disease states are different cytokines, among them tumor necrosis factor alpha (TNF-alpha) and beta (TNF-beta). This review aims to summarize the current knowledge about the primary structure and the regulation of the porcine TNF genes, as well as methods used to measure their respective proteins.
Pauli
U
U
Institute of Veterinary Virology, University of Bern, Switzerland.
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay / Q000662:veterinary; D002874:Chromosome Mapping; D005786:Gene Expression Regulation; D006801:Humans; D008233:Lymphotoxin-alpha / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012772:Shock, Septic / Q000378:metabolism / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha