Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats.
Intravenous injection of gadolinium chloride (GdCl3) at a dose of 10 mg/kg caused an increase in proliferating cell nuclear antigen labeling index and the grade of pyronin positivity (RNA level) in rat liver. In CCl4-exposed rats, pretreatment with GdCl3 also showed a preventive effect of the liver injury both biochemically and histologically. Moreover, the proliferative action preceded the attenuative effect of the liver injury. Results suggest that GdCl3 induces hepatocyte proliferation, and this action of GdCl3 may modify the development of CCl4-induced liver injury.
Ishiyama
H
H
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
Sato
M
M
Matsumura
K
K
Sento
M
M
Ogino
K
K
Hobara
T
T
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D005682:Gadolinium / Q000494:pharmacology*; D007150:Immunohistochemistry; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000893:Anti-Inflammatory Agents; D018809:Proliferating Cell Nuclear Antigen; D005682:Gadolinium; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase; C038958:gadolinium chloride