title: [Neuroleptic malignant syndrome: a review of literature].
abstract: Neuroleptic malignant syndrome is characterized by altered consciousness, fever, extrapyramidal signs and autonomic instability. Although originally described in patients receiving neuroleptic drugs, this syndrome may also occur in patients who were taking a wide variety of medications. It is a rare and potentially lethal idiosyncratic reaction that occurs after therapeutic rather than toxic doses of neuroleptics drugs and is unrelated to the duration of therapy. The implications of dopaminergic disturbances underlying the mental illnesses involved are considered. Treatment of the neuroleptic malignant syndrome involves, first of all, supportive measures and withdrawal of the neuroleptic drugs therapy.
authors.affiliation: M.I.R. Servicio de Psiquiatría, Hospital Universitario San Carlos, Madrid.
authors.forename: B
authors.initials: B
authors.lastname: Crespo Facorro
authors.forename: C
authors.initials: C
authors.lastname: Carbonell Masia
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000494:pharmacology; D003244:Consciousness Disorders; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000453:epidemiology / Q000209:etiology*
chemical_list: D014150:Antipsychotic Agents; D004298:Dopamine
vernacular_title: Síndrome neuroléptico maligno: una revisión bibliográfica.