Hydrogen ion-dependent oncogenesis and parallel new avenues to cancer prevention and treatment using a H(+)-mediated unifying approach: pH-related and pH-unrelated mechanisms.
A comprehensive examination of phenomena related to cancer is presented that is based on hydrogen ion dynamics, as viewed from the biological, biochemical, and biophysical perspective. A model is described that considers an array of cancer-associated events from oncogenesis to carcinogenesis from this perspective. The basic ideas are viewed from various aspects, ranging from the cellular level to the clinical situation. The novel types of therapeutic and prophylactic agents that result from applying these concepts are elucidated. Considerable insight into this modern approach is seen from some of the mechanisms that characterize the phenomenon of spontaneous regression of cancer.
Harguindey
S
S
Oncology Service, Clinica la Esperanza, Vitoria, Spain.
Pedraz
J L
JL
García Cañero
R
R
Pérez de Diego
J
J
Cragoe
E J
EJ
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000584:Amiloride / Q000627:therapeutic use; D000818:Animals; D002100:Cachexia / Q000378:metabolism; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009362:Neoplasm Metastasis; D009365:Neoplasm Regression, Spontaneous; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy*; D011522:Protons; D015398:Signal Transduction; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism; D014158:Transcription, Genetic
D004791:Enzyme Inhibitors; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D000584:Amiloride; D000251:Adenosine Triphosphatases