title: Biotin carboxylase comes into the fold.
abstract: Extensive three-dimensional structural resemblances between biotin carboxylase and the ADP-forming peptide synthetases, represented by glutathione synthetase and D-Ala:D-Ala ligase, reveal a previously unsuspected evolutionary relationship between two major families of ADP-forming ligases.
authors.forename: P J
authors.initials: PJ
authors.lastname: Artymiuk
authors.forename: A R
authors.initials: AR
authors.lastname: Poirrette
authors.forename: D W
authors.initials: DW
authors.lastname: Rice
authors.forename: P
authors.initials: P
authors.lastname: Willett
mesh_terms: D000595:Amino Acid Sequence; D019731:Carbon-Nitrogen Ligases; D005981:Glutathione Synthase / Q000737:chemistry / Q000378:metabolism; D008025:Ligases / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010453:Peptide Synthases / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary
chemical_list: D008025:Ligases; D019731:Carbon-Nitrogen Ligases; D010453:Peptide Synthases; D005981:Glutathione Synthase; C019638:D-alanylalanine synthetase; C019791:biotin carboxylase