Effects of interleukin-1 blockers on ophthalmic wound healing in a rabbit model of trabeculectomy.
A trabeculectomy model was used to test the efficacy of some Interleukin-1 blockers on the modulation of ophthalmic wound healing in the pigmented rabbit. The corticosteroid, methyl prednisolone, was used as a positive control and was effective in prolonging the time to failure of the trabeculectomy by 21%. The experimental compounds CK-17, CK-101A, CK-102 and CK-103A were more efficacious than vehicle control at prolonging the number of days before failure of the trabeculectomy by 55%, 55%, 30% and 79%, respectively. The CK- compounds increased the amount of time before failure of the fistula, with no side effects at the doses tested to date.
Schwade
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ND
Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.
Chiou
G C
GC
D000166:Acridines / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D007097:Imines / Q000494:pharmacology; D007267:Injections; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D007429:Intraocular Pressure; D008775:Methylprednisolone / Q000494:pharmacology; D008954:Models, Biological; D011724:Pyridazines / Q000494:pharmacology; D011817:Rabbits; D012590:Sclera / Q000601:surgery; D013047:Specific Pathogen-Free Organisms; D013524:Surgical Flaps; D013843:Thiazines / Q000494:pharmacology; D014130:Trabeculectomy; D014945:Wound Healing / Q000187:drug effects*
C091705:2-anilino-3-phenyl-1,3-thiazine; D000166:Acridines; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; C091706:CK 103A; D007097:Imines; D007375:Interleukin-1; D011724:Pyridazines; D013843:Thiazines; C097967:CK 102; C091704:CK 17; D008775:Methylprednisolone