title: Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents.
abstract: A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show IC50 values at microM levels.
authors.affiliation: Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gordaliza
authors.forename: J M
authors.initials: JM
authors.lastname: del Corral
authors.forename: M A
authors.initials: MA
authors.lastname: Castro
authors.forename: M L
authors.initials: ML
authors.lastname: López-Vázquez
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
authors.forename: M D
authors.initials: MD
authors.lastname: García-Grávalos
authors.forename: A
authors.initials: A
authors.lastname: Carpy
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D011720:Pyrazoles