title: Cumulative risk of Alzheimer-like dementia in relatives of autopsy-confirmed cases of Alzheimer's disease.
abstract: The cumulative risk of Alzheimer-like dementia (AD) was investigated in first-degree relatives (n = 176) of 35 probands with autopsy-confirmed clinical diagnoses of Alzheimer's disease. Seventeen of the 176 first-degree relatives showed evidence of AD. Cumulative morbid risk for the first-degree relatives was estimated to be 28.8%. This result is broadly consistent with previously reported studies, and affirms the presence of substantial disease risk in close relatives of those with Alzheimer's disease.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, N.C., USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Hocking
authors.forename: J C
authors.initials: JC
authors.lastname: Breitner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000473:pathology; D005190:Family; D006801:Humans; D018570:Risk Assessment