title: Takayasu's arteritis as a cause of renovascular hypertension in a non-Asian population.
abstract: Takayasu's disease (TD) is a chronic inflammatory arteritis which affects the aorta and its main branches and occasionally the pulmonary artery. Its cause is not known. Clinical manifestations are due to the intensity and location of arterial inflammation in the acute phase, as well as chronic arterial stenosis over time; 50% of patients have hypertension. Although TD appears to be more common in Asia, increasing numbers of patients of different races are observed in Western countries. The most important pathogenetic mechanism of hypertension seems to be through renal artery stenosis. We show here seven Caucasian hypertensive patients with TD and renovascular stenosis and arterial hypertension. One case was diagnosed in the acute phase of the disease, while in the others diagnosis was established in an advanced occlusive phase. Basic diagnosis was established by angiographic study, with biopsy confirmation in two cases. All patients had at least three of the six criteria listed as diagnostic of TD (by the American College of Reumatology). All patients had the following criteria: age of disease onset before 40 years (symptoms or findings related to TD), vascular bruits in different areas and all patients also had aortic and renal arterial stenosis with some lesions of the main aortic branches. Six of them had claudication of the extremities. We describe their clinical, analytical and angiographic features and also the therapeutic approach. We discuss the aetiopathogenic mechanisms of hypertension in this disease and suggest that TD is not an unusual cause of vasculorenal hypertension.
authors.affiliation: Department of Nephrology, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Castellote
authors.forename: R
authors.initials: R
authors.lastname: Romero
authors.forename: J
authors.initials: J
authors.lastname: Bonet
authors.forename: P
authors.initials: P
authors.lastname: Torguet
authors.forename: J M
authors.initials: JM
authors.lastname: Callejas
authors.forename: A
authors.initials: A
authors.lastname: Caralps
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006978:Hypertension, Renovascular / Q000208:ethnology / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies; D013625:Takayasu Arteritis / Q000150:complications* / Q000208:ethnology; D044465:White People