Aleukemic monocytic leukemia cutis.
Aleukemic leukemia cutis is a rare condition in which leukemic cells invade the skin before they appear in peripheral blood or bone marrow specimens. Herein we describe a 67-year-old man who underwent assessment because of papules and nodules on his back and lower extremities. A biopsy of these lesions confirmed a dense, predominantly monocytic infiltrate of the dermis and subcutaneous tissue. Immunohistochemical stains were positive for CD43 (Leu-22) as well as monocytic markers. Bone marrow and peripheral blood examinations failed to reveal leukemia. Treatment was based on the results of the skin biopsy, and the patient is doing well 1 year after therapy.
Daoud
M S
MS
Department of Dermatology, Mayo Clinic Rochester, Minnesota 55905, USA.
Snow
J L
JL
Gibson
L E
LE
Daoud
S
S
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*
D015703:Antigens, CD