title: Treatment of vaginal recurrence in endometrial cancer. A review.
abstract: BACKGROUND
  We have reviewed the literature concerning vaginal recurrence in endometrial cancer with emphasis on prognostics and therapeutic results. Compared to the overall outcome of recurrences (11-17 per cent survive more than 3-19 years) the survival rate of strictly vaginal recurrence appears significantly higher (up to 60-70 per cent survive more than 5 years). However, the prognosis deteriorates significantly in cases where recurrences prove to be more widespread. Other factors towards predicting a poor outcome are high age, high stage, high grade, detection of papillary carcinoma, rapid recurrence, location to the lower part of vagina, large tumor size, and previous radiation.
  
  
  METHODS
  Different methods of initial treatment and cross-relations between most prognostic factors renders any ranking of prognostic factors almost impossible.
  
  
  RESULTS
  Standard treatment of vaginal recurrence including combined external and intra vaginal radiation used for decades have been unable to improve survival rate.
  
  
  CONCLUSIONS
  We suggest a more individualized treatment based on exact delineation of the disease.
authors.affiliation: Finsen Center, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: L A
authors.initials: LA
authors.lastname: Møller
authors.forename: S A
authors.initials: SA
authors.lastname: Engelholm
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D003718:Denmark / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D014625:Vaginal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000628:therapy*