title: Fibrin sealant in surgery of patients with a hemorrhagic diathesis.
abstract: The utilization of fibrin sealants in patients with hemostatic disorders has hitherto been very limited. Our experiences from 40 major and 8 minor surgical procedures, 10 circumcisions and 118 tooth extractions in 106 patients with hemophilia A, B or von Willebrand's disease, almost exclusively of the severe form, respectively, demonstrate the benefits regarding reduction of blood loss and requirements for systemic replacement therapy. The literature on the use of fibrin sealants in this group of patients, which mainly concerns dental procedures, is reviewed and compared with our data. The importance of the composition of the glue is also discussed in detail.
authors.affiliation: National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: U
authors.initials: U
authors.lastname: Martinowitz
authors.forename: S
authors.initials: S
authors.lastname: Schulman
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D018849:Controlled Clinical Trials as Topic; D003432:Cross-Linking Reagents / Q000378:metabolism; D015718:Fibrin Tissue Adhesive / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D005884:Gingival Hemorrhage / Q000191:economics / Q000628:therapy; D006474:Hemorrhagic Disorders / Q000188:drug therapy*; D006490:Hemostatics / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D012449:Safety; D014014:Tissue Adhesives / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects / Q000191:economics; D011503:Transglutaminases / Q000378:metabolism
chemical_list: D003432:Cross-Linking Reagents; D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D014014:Tissue Adhesives; D011503:Transglutaminases