Influence of emotional-algic stress on the activity of carboxypeptidase H--an enzyme involved in processing rat brain neuropeptides.
It was established that the activity of carboxypeptidase H increases in divisions of the brain of rats during a one-time emotional-algic stress. The most substantial increase in the activity of the enzyme is observed in the hypophysis and the hypothalamus. The changes in activity were less marked with chronic emotional-algic stress. The involvement of carboxypeptidase H in the development of stress reactions, as well as the possibility of the participation of the soluble form of the enzyme in the processing of secretory peptides, and of the membrane-bound form in the processing of neuropeptides with a central action, is hypothesized.
Gengin
M T
MT
Department of Chemistry, V. G. Belinskii State Pedagogical Institute, Penza.
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D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry / Q000502:physiology; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D004558:Electric Stimulation; D004644:Emotions / Q000502:physiology*; D007031:Hypothalamus / Q000201:enzymology; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D010146:Pain / Q000201:enzymology / Q000523:psychology*; D010904:Pituitary Gland, Posterior / Q000201:enzymology; D051381:Rats; D013315:Stress, Psychological / Q000201:enzymology / Q000523:psychology*
D009479:Neuropeptides; D002268:Carboxypeptidases; D043423:Carboxypeptidase H