title: Improvement of scleredema associated with IgA multiple myeloma after chemotherapy.
abstract: The presence of a monoclonal gammopathy in patients with chronic scleredema is a recently described, unusual association of unknown significance. There have been very occasional reports of multiple myeloma in such patients. We now report a patient with long-standing scleredema who developed an IgA-kappa multiple myeloma. Once chemotherapy for the myeloproliferative disorder was instituted, scleredema improved significantly, suggesting a pathogenetic link between the two conditions.
authors.affiliation: Department of Dermatology, Hospital Clinico Universitario, Faculty of Medicine, Zaragoza, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Pujol
authors.forename: M
authors.initials: M
authors.lastname: Bueno
authors.forename: M A
authors.initials: MA
authors.lastname: Fuertes
authors.forename: H
authors.initials: H
authors.lastname: Gimenez
authors.forename: F J
authors.initials: FJ
authors.lastname: Carapeto
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000473:pathology
chemical_list: D007070:Immunoglobulin A