MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4.
Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I-selected CD4-CD8-TCR alpha beta+ T cells, potentially implicated in the development of specific Th2 immune cells, is reviewed.
Leite-de-Moraes
M C
MC
Université René Descartes, Paris, France.
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D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation; D005805:Genes, MHC Class I / Q000502:physiology*; D015847:Interleukin-4 / Q000502:physiology*; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000502:physiology*
D016693:Receptors, Antigen, T-Cell, alpha-beta; D015847:Interleukin-4