title: Effects of inhibitory amino acids on the frequency components in sympathetic nerve discharge.
abstract: The effects of the GABA antagonist picrotoxin and the glycine antagonist strychnine on the frequency components in sympathetic inferior cardiac nerve activity were observed. Picrotoxin (0.03-1.0 mg/kg) increased power in the 10-Hz component of sympathetic activity and produced a dramatic shift in the rhythm to higher frequencies. Only small changes were noted in the 2- to 6-Hz component. Strychnine produced a small generalized increase in power in both frequency bands in sympathetic activity. These data suggest that GABA may play an important role in the generation and maintenance of the 10-Hz rhythm in sympathetic activity while glycine likely inhibits activity at a site of convergence of the two rhythms in sympathetic activity.
authors.affiliation: The Upjohn Co., Kalamazoo, MI 49001, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Clement
authors.forename: R B
authors.initials: RB
authors.lastname: McCall
mesh_terms: D000818:Animals; D002415:Cats; D004594:Electrophysiology; D018756:GABA Antagonists / Q000494:pharmacology; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D018684:Glycine Agents / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D018756:GABA Antagonists; D005998:Glycine; D018684:Glycine Agents; D018377:Neurotransmitter Agents; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid