title: [General argyria caused by administration of tobacco-withdrawal tablets containing silver acetate].
abstract: In a 49-year-old man generalised argyria was diagnosed, a systemic dissemination and tissue deposition of silver in the body. The clinical picture was brought about by use of a silver acetate-containing lozenge as a deterrent to smoking. Argyria is characterised by a slate blue-gray discolouration of the skin, particularly in areas exposed to light. Generally, it causes patients a great deal of anguish and embarrassment. Present understanding is that it does not entail non-cutaneous, systemic effects. There is no effective treatment--the discolouration is permanent. Currently, prevention is the only possible measure. Efforts should be made to eliminate the uncontrolled use of silver-containing preparations.
authors.affiliation: Algemeen Ziekenhuis Sint-Blasius, afd. Inwendige Ziekten, Dendermonde, België.
authors.forename: L
authors.initials: L
authors.lastname: Van Garsse
authors.forename: J
authors.initials: J
authors.lastname: Versieck
mesh_terms: D000085:Acetates / Q000009:adverse effects*; D019342:Acetic Acid; D000643:Ammonium Chloride / Q000009:adverse effects*; D001129:Argyria / Q000097:blood / Q000209:etiology*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000009:adverse effects; D012834:Silver / Q000097:blood; D000074606:Smoking Prevention
chemical_list: D000085:Acetates; D004338:Drug Combinations; D004366:Nonprescription Drugs; D000643:Ammonium Chloride; D012834:Silver; C019076:Respaton; D019342:Acetic Acid
vernacular_title: Veralgemeende argyrose door het gebruik van tabak-ontwenningstabletten met zilveracetaat.