title: Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation.
abstract: The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97 +/- 0.1 microM. Mevalonate (100 microM), as well as geranylgeraniol (5 microM), at their highest non-toxic concentrations, restored cell proliferation to control levels.
authors.affiliation: Institute of Pharmacological Sciences, University of Milan, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Viganõ
authors.forename: A
authors.initials: A
authors.lastname: Hernandez
authors.forename: A
authors.initials: A
authors.lastname: Corsini
authors.forename: A
authors.initials: A
authors.lastname: Granata
authors.forename: P
authors.initials: P
authors.lastname: Belloni
authors.forename: R
authors.initials: R
authors.lastname: Fumagalli
authors.forename: R
authors.initials: R
authors.lastname: Paoletti
authors.forename: G
authors.initials: G
authors.lastname: Folco
mesh_terms: D001980:Bronchi / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D008798:Mevalonic Acid / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects; D019821:Simvastatin
chemical_list: D004224:Diterpenes; D004791:Enzyme Inhibitors; D008148:Lovastatin; D019821:Simvastatin; C017338:geranylgeraniol; D008798:Mevalonic Acid