[Effects of Chinese ginseng root and stem-leaf saponins on learning, memory and biogenic monoamines of brain in rats].
The present investigation has shown that Ginseng root saponins (ig, 50mg/kg x 7d) facilitate the learning and memory of normal male Wistar rats, while the effect of Ginseng stem-leaf saponins (ig, 50mg/kg x 7d) on antielectrconvulsive shock-induced impairment of memory consolidation in rats is more intensive than that of root saponins. Both Ginseng root and stem-leaf saponins can significantly raise the levels of biogenic monoamines in normal rat's brain.
Wang
A
A
Shenyang Pharmaceutical University.
Cao
Y
Y
Wang
Y
Y
Zhao
R
R
Liu
C
C
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000302:isolation & purification / Q000494:pharmacology*; D036145:Ginsenosides; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D005894:Panax / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D015306:Biogenic Monoamines; D002491:Central Nervous System Agents; D036145:Ginsenosides; D012503:Saponins