AH17, a new non-polyenic antifungal antibiotic produced by a strain of Spirillospora.
An antibiotic (AH17) was produced by Spirillospora strain 719. This substance was obtained only from the broth filtrate after precipitation with acetic acid followed by extraction with n-butanol. Its purification was carried out by thin layer chromatography on silica gel followed by HPLC procedures. It showed activity against Gram-positive and Gram-negative bacteria and fungi. The spectroscopic and chemical properties were examined and indicated that AH17 was a quinone. It seems that this is a new antibiotic from Spirillospora.
Hacène
H
H
Laboratoire de Microbiologie, Université des Sciences et de la Technologie Houari-Boumediène, Alger-Gare, Algeria.
Lefebvre
G
G
D000192:Actinomycetales / Q000378:metabolism*; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D005658:Fungi / Q000187:drug effects / Q000254:growth & development
D000935:Antifungal Agents