Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma.
We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.
Michel
M
M
Department of Radiology, Institut Gustave Roussy, Villejuif, France.
Vincent
F
F
Sigal
R
R
Damaj
G
G
Bensousan
T A
TA
Leclercq
B
B
Escudier
B
B
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology
D007376:Interleukin-2