Efficacy and tolerance of insoluble carob fraction in the treatment of travellers' diarrhoea.
The water-insoluble carob fraction (fraction insoluble caroube, FIC, Nestlé) has been successfully used in the treatment of infantile diarrhoea. To investigate the efficacy and toxicity of FIC (1970 mg to be taken every 2 hours over a 48-hour period except during sleeping time) in the treatment of travellers' diarrhoea in adults, a double-blind, computer randomized, placebo-controlled study was conducted. Of the 755 volunteers recruited at the Zurich University Vaccination Centre, 628 (83.5%) returned their questionnaires. Among them, 164 (27.7%) had diarrhoea, but only 69 (42%) used the trial medication correctly; the others were rated non-complaint. No significant difference in efficacy (p = 0.12) or adverse effects were observed in the two study groups. In conclusion, FIC, although showed a positive trend, was not efficacious.
Hostettler
M
M
Division of Epidemiology and Prevention of Communicable Diseases, Institute of Social and Preventive Medicine of the University, Zurich, Switzerland.
Steffen
R
R
Tschopp
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000930:Antidiarrheals / Q000009:adverse effects / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005685:Galactans; D006801:Humans; D008297:Male; D008351:Mannans; D008875:Middle Aged; D053149:Plant Gums; D011134:Polysaccharides / Q000009:adverse effects / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D014195:Travel; D016896:Treatment Outcome
D000930:Antidiarrheals; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; C017471:locust bean gum