Organization of the provisional fibronectin matrix: control by products of blood coagulation.
Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal modules and occurs at specialized cell surface sites. Cellular display of assembly sites is labile and requires that cells be under tension and have functional beta 1 integrins. Lysophosphatidic acid (LPA) an intermediate for de novo lipid biosynthesis and a product of platelet activation, is a powerful serum modulator of fibronectin assembly.
Mosher
D F
DF
Department of Medicine, University of Wisconsin, Madison 53706, USA.
D000818:Animals; D001777:Blood Coagulation; D003599:Cytoskeleton / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000737:chemistry*; D005353:Fibronectins / Q000737:chemistry*; D008055:Lipids / Q000096:biosynthesis; D008246:Lysophospholipids / Q000502:physiology; D008958:Models, Molecular; D015539:Platelet Activation; D011487:Protein Conformation; D051381:Rats; D013499:Surface Properties; D014982:Xenopus laevis
D005353:Fibronectins; D008055:Lipids; D008246:Lysophospholipids