The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments.
Many bacterial pathogens and eukaryotic parasites can enter mammalian cells and live intracellularly inside membrane-bound vacuoles. The intravacuolar lifestyle of these pathogens plays a key role in pathogenesis. Understanding the molecular basis of the development of these specialized intracellular compartments is critical to understanding how these organisms cause disease.
Garcia-del Portillo
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Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Facultad de Biología, Universidad Autónoma de Madrid, Spain.
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D000818:Animals; D018407:Bacterial Physiological Phenomena; D004912:Erythrocytes / Q000382:microbiology / Q000469:parasitology; D006790:Host-Parasite Interactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010271:Parasites / Q000502:physiology*; D010588:Phagosomes; D014617:Vacuoles / Q000382:microbiology* / Q000469:parasitology*