Clozapine-caused eosinophilic colitis.
Four patients with diarrhea and eosinophilia associated with clozapine therapy are presented. In two cases clozapine therapy was interrupted but then restarted; all patients eventually tolerated clozapine well. A syndrome of clozapine-induced eosinophilic colitis is suggested.
Friedberg
J W
JW
McLean Hospital, Belmont, Massachusetts 02178, USA.
Frankenburg
F R
FR
Burk
J
J
Johnson
W
W
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003092:Colitis / Q000150:complications* / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D003024:Clozapine