[Immunology of tuberculosis].
Protective immunity against Mycobacterium tuberculosis is mediated by specific T lymphocytes and executed by mononuclear phagocytes. The crosstalk between distinct T cell subsets and macrophages involves various cytokines. Attraction of blood monocytes to the site of mycobacterial replication and local macrophage activation result in granuloma formation. Interactions between T cell subsets and macrophages within granulomas enable the host to restrict mycobacterial growth, but only rarely cause sterile eradication. Therefore, at later time points, active tuberculosis may develop as a consequence of weakened immunity.
Kaufmann
S H
SH
Abteilung für Immunologie, Universität Ulm und Max-Planck-Institut für Infektionsbiologie, Berlin.
D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008211:Lymphocyte Cooperation / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D010587:Phagocytosis; D013601:T-Lymphocytes / Q000276:immunology; D014375:Tuberculoma / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
Immunologie der Tuberkulose.