Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice.
Cis-urocanic acid, converted from trans-urocanic acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-urocanic acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-urocanic acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-urocanic acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-urocanic acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-urocanic acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate.
Lauerma
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Department of Dermatology, University of California, San Francisco 94143-0989, USA.
Aioi
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A
Maibach
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HI
D000287:Administration, Topical; D000485:Allergens; D000818:Animals; D003436:Croton Oil; D003877:Dermatitis, Contact / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D007509:Irritants; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone; D010796:Phthalic Anhydrides; D014560:Urocanic Acid / Q000008:administration & dosage*
D000485:Allergens; D007509:Irritants; D010796:Phthalic Anhydrides; D010081:Oxazolone; D003436:Croton Oil; C015559:trimellitic anhydride; D014560:Urocanic Acid