Drug removal in continuous haemofiltration and haemodialysis.
Although both continuous haemofiltration and continuous haemodialysis are techniques routinely employed in the management of critically ill patients, deciding on a drug dosing regimen is often difficult. This article highlights the factors influencing drug removal by both processes, the difficulties associated with the interpretation of research in this area and offers a number of approaches which can be used when selecting a dosing regimen for a patient receiving one of these therapies.
Davies
J G
JG
Department of Pharmacy, University of Brighton.
Kingswood
J C
JC
Sharpstone
P
P
Street
M K
MK
D003404:Creatinine / Q000378:metabolism; D016903:Drug Monitoring; D006440:Hemofiltration; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D006435:Renal Dialysis
D004364:Pharmaceutical Preparations; D003404:Creatinine