[The diagnostic and prognostic significance of the indices of the immune response to streptococcal group A antigens in rheumatism].
Serum samples obtained from 33 patients with acute rheumatic fever (ARF), 60 patients with rheumatic heart disease (RHD) and 30 adult healthy persons have been studied. Antibodies to streptococcal A polysaccharide (SAP) and lypoteichoic acid (LTA) were examined by ELISA, to streptolysin O by standard technique. SAP antibodies in high titers persisted from 5 to 12 months in ARF and rheumatic carditis patients especially when RHD was developing. High titers of antibodies to LTA and SLO persisted for 3 months since ARF onset, then fell (p < 0.05). ELISA proved sensitive in determination of antibodies to SAP and LTA. Its combination with determination of the titers to SLO antigens confirmed Streptococcus A infection involvement in emergence of ARF in all the cases including insidious or late-onset carditis and chorea. High levels of antibodies to SAP and LTA were more frequently detected in patients with RHD than in healthy persons (p < 0.001). Correlation between frequency of high levels of antibodies to SAP and bicillin 5 or erythromycin administration, duration of RHD was not established.
Miasoedova
S E
SE
Bobkov
V A
VA
Andreeva
D V
DV
Shevelev
B I
BI
Dmitrieva
N F
NF
Briko
N I
NI
Vylegzhanina
E S
ES
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012216:Rheumatic Diseases / Q000175:diagnosis*; D012213:Rheumatic Fever / Q000175:diagnosis; D012214:Rheumatic Heart Disease / Q000175:diagnosis; D013297:Streptococcus pyogenes / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial
Diagnosticheskoe i prognosticheskoe znachenie pokazateleĭ immunnogo otveta na antigeny streptokokka gruppy A pri revmatizme.