title: Normal levels of soluble E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease with age.
abstract: sE-selectin, sICAM-1, sVCAM-1 and von Willebrand factor (vWF) were assayed in 238 samples in a longitudinal study of 81 normal children from 9.5 to 15.5 years old. Multilevel modelling was used to quantify changes with age. sE-selectin, sICAM-1 and sVCAM-1 all fell significantly over the age range (by 17%, 16%, and 10%, respectively). In contrast, levels of vWF were not age-dependent. Our findings highlight the need for age-matched controls when studying cell surface adhesion molecules in disease groups, and may imply developmental changes in expression of these molecules and their shedding from the cell surface.
authors.affiliation: Department of Epidemiology and Biostatistics, Institute of Child Health, London, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Nash
authors.forename: A M
authors.initials: AM
authors.lastname: Wade
authors.forename: V
authors.initials: V
authors.lastname: Shah
authors.forename: M J
authors.initials: MJ
authors.lastname: Dillon
mesh_terms: D000293:Adolescent; D000375:Aging / Q000276:immunology*; D002648:Child; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012016:Reference Values; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1