title: Plasma ionized calcium in brain-dead patients.
abstract: BACKGROUND
  The mechanism of brain death-induced myocardial dysfunction remains debatable. Hypocalcemia is known to induce reversible myocardial dysfunction. However, the incidence of hypocalcemia and its effect on myocardial function during brain death is unknown.
  
  
  METHODS
  In 54 consecutive brain-dead patients, we measured plasma total and ionized calcium concentrations, QT and corrected QT intervals, and left ventricular ejection fraction area (LVEFa), using transesophageal echocardiography.
  
  
  RESULTS
  49 (91%) of brain-dead patients had a decrease in total plasma total calcium concentration but only 19 (35%) had a decrease in plasma ionized calcium. Corrected total plasma calcium failed to predict ionized calcium concentration and QT intervals were not significantly different in normo and hypocalcemic patients. The LVEFa was not significantly different between normo and hypocalcemic patients (53 +/- 13 versus 50 +/- 20%), and no correlation was found between LVEFa and ionized calcium (R = 0.02, NS). Hypocalcemic patients required greater doses of dopamine (8.2 +/- 5.2 versus 5.0 +/- 3.4 micrograms.kg-.min-1, p < 0.02) to maintain arterial pressure. Hypocalcemia was associated with a higher volume loading and a lower plasma protide concentration which reflected hemodilution.
  
  
  CONCLUSIONS
  A decrease in plasma ionized calcium is not frequent, rarely severe, and probably not the main mechanism of myocardial dysfunction in brain-dead patients. Hypocalcemic patients required higher doses of dopamine, suggesting a decrease in systemic resistance. Only direct measurement of ionized calcium can assess plasma calcium ion status in brain-dead patients.
authors.affiliation: Département d'Anesthésie-Réanimation, Groupe Hospitalier Pitié-Salpêtrière, Université Paris VI, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Fulgenico
authors.forename: B
authors.initials: B
authors.lastname: Riou
authors.forename: C
authors.initials: C
authors.lastname: Devilliers
authors.forename: R
authors.initials: R
authors.lastname: Guesde
authors.forename: M
authors.initials: M
authors.lastname: Saada
authors.forename: P
authors.initials: P
authors.lastname: Viars
mesh_terms: D000328:Adult; D001926:Brain Death / Q000097:blood* / Q000503:physiopathology; D002118:Calcium / Q000097:blood*; D004298:Dopamine / Q000008:administration & dosage; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000097:blood* / Q000503:physiopathology; D015994:Incidence; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016277:Ventricular Function, Left
chemical_list: D002118:Calcium; D004298:Dopamine