[Neurotransplantation in Parkinson disease: experimental and clinical results of functional reconstruction of the dopaminergic system].
The first results on functional effects induced by embryonic nigral grafts in the rat model of Parkinson's disease (PD) were reported in the late 70 s. It took another 10 years before the first publications on PD patients demonstrated clinical and neuroradiological signs of improvement after the transplantation of allogeneic embryonic nigral grafts. Technical details as well as clinical results varied considerably in the first clinical studies. In the last years crucial questions have been identified, also because of increasing international cooperation, which represent a challenge jointly to basic and clinical scientists. The clarification of those questions related to scientific and ethical issues will determine which impact the transplantation of embryonic nigral dopamine neurons will have as a potential therapy for PD in clinical medicine.
Nikkhah
G
G
Neurochirurgische Klinik, Krankenhaus Nordstadt, Hannover.
Brandis
A
A
D000818:Animals; D001931:Brain Mapping; D016380:Brain Tissue Transplantation; D016332:Fetal Tissue Transplantation; D006801:Humans; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000175:diagnosis / Q000601:surgery*; D011699:Putamen / Q000601:surgery; D051381:Rats; D013378:Substantia Nigra / Q000196:embryology / Q000637:transplantation*
Neurotransplantation bei Morbus Parkinson: Experimentelle und klinische Ergebnisse der funktionellen Rekonstruktion des dopaminergen Systems.