Keratinocyte-derived cytokines and UVB-induced immunosuppression.
Ultraviolet radiation (UVB) in sunlight is known to have multiple effects on the immune system. Evidence suggests that UVB-induced immunosuppression is mediated in part by immunosuppressive and immunoregulatory cytokines. Our studies have utilized gene-targeted mutant mice to determine key molecular requirements essential for the development of UVB-induced immunosuppression. Preliminary results from our laboratory suggest that TNF-alpha plays a regulatory role in contact hypersensitivity, but is not a crucial factor for UVB-induced immunosuppression, and that multiple factors are involved in the induction of UVB mediated immunosuppression.
Kondo
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Division of Dermatology, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Sauder
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DN
D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D007108:Immune Tolerance / Q000528:radiation effects*; D015603:Keratinocytes / Q000276:immunology / Q000528:radiation effects*; D051379:Mice; D014466:Ultraviolet Rays / Q000009:adverse effects*
D016207:Cytokines