Effect of chemotherapy on growth.
Growth restriction has been demonstrated clearly following the treatment of childhood malignancies, even in the absence of irradiation to the hypothalamic-pituitary axis. The use of CT and spinal irradiation in the original treatment of brain tumours has a marked effect on growth. This effect is most profound in children who have received both treatments and cannot be overcome using GH therapy at conventional doses.
Ogilvy-Stuart
A L
AL
Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
Shalet
S M
SM
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy
D000970:Antineoplastic Agents