Inhibition of tumor necrosis factor activity fails to restore 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of the antibody response to sheep red blood cells.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity is characterized in part by a profound suppression in T cell-dependent antibody production to sheep red blood cells (SRBC); however the mechanisms involved in antibody suppression are not fully understood. Recent studies from several different laboratories have suggested that increased tumor necrosis factor (TNF) activity may mediate some of the toxicity associated with TCDD exposure. The current studies were designed to evaluate the role TNF plays in TCDD-induced suppression of the antibody response. We examined the effects of exogenous TNF alpha and the effects of blocking TNF activity with a soluble TNF receptor (rhuTNFR:Fc) on antibody production in control and TCDD exposed C57B1/6 mice. Results indicate that under certain conditions, increased TNF can suppress antibody production to SRBC, but TNF does not appear to mediate TCDD-induced antibody suppression.
Moos
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College of Veterinary Medicine, Oregon State University, Corvallis 97331-7304, USA.
Kerkvliet
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D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007274:Injections, Intraperitoneal; D051379:Mice; D008810:Mice, Inbred C57BL; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology / Q000502:physiology*
D007141:Immunoglobulin Fc Fragments; D000072317:Polychlorinated Dibenzodioxins; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha