title: Modified allergen immunotherapy: effect on immunoglobulin E production.
abstract: New forms of allergen immunotherapy are proposed employing modified allergens that induce T-cell responses without associated increased IgE-related responses. Synthetic polyelectrolytes attached to an analyte amy modulate T- and B-cell function, producing effective desensitization and altering immunoglobulin production dependent on the physico-chemical nature of the carrier molecule.
authors.affiliation: Russian Federal Institute of Immunology and Academy of Sciences of Russia, Moscow.
authors.forename: A A
authors.initials: AA
authors.lastname: Babakhin
authors.forename: R M
authors.initials: RM
authors.lastname: Khaitov
authors.forename: R V
authors.initials: RV
authors.lastname: Petrov
mesh_terms: D000485:Allergens / Q000737:chemistry / Q000627:therapeutic use*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004573:Electrolytes / Q000737:chemistry; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000187:drug effects*; D007167:Immunotherapy; D008214:Lymphocytes / Q000187:drug effects; D011108:Polymers / Q000494:pharmacology
chemical_list: D000485:Allergens; D004573:Electrolytes; D011108:Polymers; D007073:Immunoglobulin E