[Ki-1 positive non-Hodgkin's lymphoma disclosed by mucocutaneous ulcerations and glomerulonephritis].
Malignant lymphoma particularly of T phenotype can be associated with specific or non specific cutaneous lesions. These cutaneous manifestations can occur at the onset of the disease being sometimes the revealing sign or they can appear during the course of the lymphoreticular malignancies. Glomerulonephritis was also described in lymphoma. Ki-1 positive large cell lymphoma was recently identified. A new case is reported with lymphadenopathy and intestinal localisation revealed by cutaneous and mucosal ulcerations principally in the mouth and a focal segmental glomerulonephritis with endo- and extracapillary proliferation. The absence of lymphoma in cutaneous and renal lesions and the clinical presentation support the hypothesis of paraneoplastic manifestations, may be related to a vasculitis.
Bellou
A
A
Service de médecine D, médecine interne, immunologie clinique et allergologie, CHU, hôpital Central, Nancy, France.
de Korwin
J D
JD
Boman-Ferran
F
F
Cuny
J F
JF
Kessler
M
M
D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology
Lymphome non hodgkinien Ki-1 positif révélé par des ulcérations cutanéomuqueuses et une glomérulonéphrite.