Tissue factor initiation of disseminated intravascular coagulation in filovirus infection.
Filovirus infections in humans and primates cause intrinsic activation of the clotting cascade. Tissue factor, the normal activator of the clotting cascade, is released into the bloodstream from activated leukocytes and viral budding from infected cells. This release of tissue factor, a trans-membrane protein found in large amounts in cells preferred by filoviruses for replication, initiates the hemorrhagic complications characteristic of filovirus infection. These complications contribute to the high mortality rates of filovirus infections. Directing chemotheraputic measures at the release of tissue factor, which causes the hemorrhagic complications, will result in significant reductions of mortality rates in man and primates.
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State University At Stony Brook, NY 11794, USA.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002477:Cells / Q000821:virology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D016563:Filoviridae / Q000472:pathogenicity / Q000502:physiology; D018702:Filoviridae Infections / Q000097:blood / Q000150:complications* / Q000401:mortality / Q000662:veterinary; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D010431:Pentoxifylline / Q000627:therapeutic use; D018419:Primate Diseases / Q000097:blood / Q000821:virology; D011323:Primates; D013925:Thromboplastin / Q000276:immunology / Q000502:physiology*; D014759:Viral Envelope Proteins / Q000502:physiology; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D014759:Viral Envelope Proteins; D013925:Thromboplastin; D010431:Pentoxifylline