kappa-1 Opioid receptors of the temporal cortex are preserved in Alzheimer's disease.
The binding of [3H]-U-69593 and [3H]-CI-977 to kappa-1 opioid receptors has been examined in the temporal cortex of postmortem brains from patients with Alzheimer's disease and age-matched controls using quantitative autoradiography. There was no significant difference between Alzheimer and control subjects in the level of [3H]-U-69593 and [3H]-CI-977 binding, but ChAT activity was markedly reduced (by 73% compared to controls). These results are not consistent with a presynaptic localisation of kappa-1 receptors on cholinergic terminals in human temporal cortex.
Mackay
K B
KB
Wellcome Neuroscience Group, Wellcome Surgical Institute & Hugh Fraser Neuroscience Labs., University of Glasgow, Scotland, United Kingdom.
Dewar
D
D
McCulloch
J
J
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D001345:Autoradiography; D044482:Benzeneacetamides; D001667:Binding, Competitive; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011759:Pyrrolidines / Q000494:pharmacology; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D044482:Benzeneacetamides; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; C045444:U 69593