title: Angiotensin-converting enzyme (ACE) gene polymorphism in type II diabetic patients with increased albumin excretion rate.
abstract: Approximately one in three patients with diabetes is at risk of developing kidney disease, despite current methods of treatment. It has long been suspected that diabetic kidney disease has a genetic basis, but this has been difficult to prove. Polymorphisms of the angiotensin-converting enzyme (ACE) gene have been shown to be related to the occurrence of nephropathy in type I diabetic patients. This study showed that there was no association in the ACE genotype frequency and increased albumin excretion rate in type II diabetic patients.
authors.affiliation: Endocrine Unit, Austin Hospital, Heidelberg, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Panagiotopoulos
authors.forename: T J
authors.initials: TJ
authors.lastname: Smith
authors.forename: G P
authors.initials: GP
authors.lastname: Aldred
authors.forename: E J
authors.initials: EJ
authors.lastname: Baker
authors.forename: C J
authors.initials: CJ
authors.lastname: Jacklin
authors.forename: G
authors.initials: G
authors.lastname: Jerums
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000453:epidemiology / Q000503:physiopathology*; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000235:genetics / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics* / Q000652:urine; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A