title: Determination of a tolerable daily intake of DDT for consumers of DDT contaminated fish from the lower Yakima River, Washington.
abstract: DDT, DDE, and DDD have been detected at elevated concentrations in sediments and fish of the Yakima River, its tributaries and drainages. An assessment was conducted to evaluate the public health significance of eating fish from the river. This was accomplished by establishing a daily intake level of DDT for the population of greatest concern, and comparing this level to a tolerable daily intake. The most sensitive and highly exposed group was determined to be breastfeeding infants. Infant daily intakes of DDT, based on estimated mother's DDT-breast milk levels, were compared to a recommended tolerable daily intake. Results indicate that mothers who frequently consume Yakima River bottom-feeding fish could have breast milk DDT concentrations sufficiently high to expose their infants to levels above the tolerable daily intake.
authors.affiliation: State of Washington, Department of Health, Olympia 98504-7825, USA.
authors.forename: K
authors.initials: K
authors.lastname: Mariën
authors.forename: D M
authors.initials: DM
authors.lastname: Laflamme
mesh_terms: D000818:Animals; D001942:Breast Feeding; D002273:Carcinogens / Q000032:analysis; D003634:DDT / Q000032:analysis; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis; D003632:Dichlorodiphenyldichloroethane / Q000032:analysis; D005260:Female; D005399:Fishes; D005504:Food Analysis; D005506:Food Contamination; D006801:Humans; D007223:Infant; D007306:Insecticides / Q000032:analysis; D008055:Lipids / Q000032:analysis; D008452:Maximum Allowable Concentration; D008895:Milk, Human / Q000737:chemistry; D011634:Public Health; D018570:Risk Assessment; D014861:Washington
chemical_list: D002273:Carcinogens; D007306:Insecticides; D008055:Lipids; D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D003632:Dichlorodiphenyldichloroethane