Long-term survivors of HIV-1 infection.
The clinical course and outcome of HIV-1 infection are highly variable. A full spectrum of pathology has been observed, from rapid progression to AIDS within months of HIV-1 seroconversion, to asymptomatic survival for more than a decade. This phenomenon probably reflects the multiphasic and multifactorial nature of the virus-host interactions. Obviously, interest in the extremes now recognized in HIV-1 disease progression is growing, with the hope that mechanisms of protection may be found.
Klein
M R
MR
Dept of Clinical Viro-immunology, Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
Miedema
F
F
D018450:Disease Progression; D005544:Forecasting; D015658:HIV Infections / Q000453:epidemiology / Q000503:physiopathology*; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D007113:Immunity, Innate; D017741:Survivors; D009626:Terminology as Topic