title: Cyclosporine-associated mutism in liver transplant patients.
abstract: Four liver transplant recipients treated with cyclosporine developed a reversible neurologic syndrome characterized by a speech disorder leading to mutism. This complication, previously reported in a few liver transplant recipients treated with the immunosuppressive drug FK506, had not been described with cyclosporine. Recognition of this syndrome should prompt withdrawal of the drug and avoidance of unnecessary diagnostic procedures.
authors.affiliation: Service of Neurology, Hospital Clínic i Provincial, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Valldeoriola
authors.forename: F
authors.initials: F
authors.lastname: Graus
authors.forename: A
authors.initials: A
authors.lastname: Rimola
authors.forename: H
authors.initials: H
authors.lastname: Andreu
authors.forename: J
authors.initials: J
authors.lastname: Santamaria
authors.forename: A
authors.initials: A
authors.lastname: Catafau
authors.forename: J
authors.initials: J
authors.lastname: Visa
authors.forename: E
authors.initials: E
authors.lastname: Tolosa
authors.forename: J
authors.initials: J
authors.lastname: Rodés
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009155:Mutism / Q000139:chemically induced*
chemical_list: D016572:Cyclosporine