title: [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist].
abstract: A platelet-activating factor (PAF) antagonist was found to inhibit superoxide production in the leukocytes of patients with type IIA hypercholesterolemia. PAF (10(-7)-10(-6) M) alone failed to stimulate superoxide production in intact or PAF-antagonist-treated leukocytes. The PAF-antagonist-induced inhibition of superoxide production was observed in the leukocytes from hypercholesterolemic patients whose plasma cholesterol levels varied from 8.3 to 14.0 mmole/l.
authors.forename: G I
authors.initials: GI
authors.lastname: Muzia
authors.forename: N S
authors.initials: NS
authors.lastname: Bol'shakova
authors.forename: I F
authors.initials: IF
authors.lastname: Cherniad'eva
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
authors.forename: V I
authors.initials: VI
authors.lastname: Kulikov
mesh_terms: D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D013481:Superoxides / Q000037:antagonists & inhibitors*
chemical_list: D010713:Phosphatidylcholines; D010972:Platelet Activating Factor; D013481:Superoxides
vernacular_title: Ingibirovanie obrazovaniia superoksidnykh radikalov leĭkotsitami krovibol'nykh s giperkholesterinemieĭ pod vliianiem lipidnogo antagonista faktora aktivatsii trombotsitov.