Chromosomal translocations in two feline T-cell lymphomas.
Two feline malignant lymphoma cell lines, FT-1 and FT-G, established from cats naturally infected with the feline leukemia virus were analyzed for chromosomal aberrations. Both FT-1 and FT-G cells had a modal number of 38 which is the normal diploid (2n) chromosome number of the domestic cat. G-banding-analysis showed that FT-1 had a translocation involving the short arms of chromosome A2 and D3--t (A2;D3) (p-;p+), and FT-G had a translocation involving the short arms of chromosomes A2 and B2--t (A2;B2) (p-;p+). Our data suggest that the chromosomal translocations were closely associated with the tumorigenesis in malignant lymphoma in cats.
Wu
F Y
FY
Department of Maternal and Child Health, Faculty of Medicine, University of Tokyo, Japan.
Iijima
K
K
Tsujimoto
H
H
Tamura
Y
Y
Higurashi
M
M
D000818:Animals; D002415:Cats; D002871:Chromosome Banding; D007621:Karyotyping; D005256:Leukemia Virus, Feline; D016399:Lymphoma, T-Cell / Q000235:genetics*; D012192:Retroviridae Infections / Q000235:genetics; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000235:genetics