title: Pyridoxine in atopic dermatitis.
abstract: A previous study has reported benefit when pyridoxine hydrochloride was given to patients with atopic dermatitis. To investigate this in children, we performed a randomized, double-blind, parallel-group, placebo-controlled trial. Forty-eight children with moderate or severe atopic dermatitis were recruited and, of those who completed the study, 19 received pyridoxine hydrochloride 50 mg once daily for 4 weeks and 22 received placebo. Disease activity was monitored by clinical severity scores measuring the extent and degrees of erythema recorded by the investigator and symptom scores (daytime itch and nocturnal sleep disturbance) recorded by parents. There was no statistically significant difference between the two groups at the end of treatment. We have been unable to demonstrate clinical benefit from pyridoxine supplementation in children with atopic dermatitis.
authors.affiliation: Department of Child Health, University of Manchester, Booth Hall Children's Hospital, Blackley, U.K.
authors.forename: D C
authors.initials: DC
authors.lastname: Mabin
authors.forename: S
authors.initials: S
authors.lastname: Hollis
authors.forename: J
authors.initials: J
authors.lastname: Lockwood
authors.forename: T J
authors.initials: TJ
authors.lastname: David
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011736:Pyridoxine / Q000627:therapeutic use*; D012720:Severity of Illness Index; D017211:Treatment Failure
chemical_list: D003879:Dermatologic Agents; D011736:Pyridoxine