title: [123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease.
abstract: We have used in vivo single-photon emission computed tomography (SPECT) of the dopamine transporter with 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane ([123I] beta-CIT) to investigate striatal dopamine transporter loss in patients with early Parkinson's disease (PD). Striatal uptake of ([123I] beta-CIT was compared in eight early-PD patients with exclusively hemi-parkinsonism and eight age- and sex-matched healthy subjects. [123I] beta-CIT striatal uptake was reduced by approximately 53% contralateral and by 38% ipsilateral to the clinically symptomatic side in the hemi-PD patients, compared with the mean striatal uptake in age- and sex-matched healthy subjects. The relative reduction in [123I] beta-CIT uptake in the hemi-PD patients was greater in the putamen than in the caudate. These data demonstrate that SPECT imaging of the dopamine transporter with [123I] beta-CIT can identify patients with PD at the onset of motor symptoms and suggest that this technique also may be useful in identifying individuals with developing dopaminergic pathology before onset of motor symptoms.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Marek
authors.forename: J P
authors.initials: JP
authors.lastname: Seibyl
authors.forename: S S
authors.initials: SS
authors.lastname: Zoghbi
authors.forename: Y
authors.initials: Y
authors.lastname: Zea-Ponce
authors.forename: R M
authors.initials: RM
authors.lastname: Baldwin
authors.forename: B
authors.initials: B
authors.lastname: Fussell
authors.forename: D S
authors.initials: DS
authors.lastname: Charney
authors.forename: C
authors.initials: C
authors.lastname: van Dyck
authors.forename: P B
authors.initials: PB
authors.lastname: Hoffer
authors.forename: R P
authors.initials: RP
authors.lastname: Innis
mesh_terms: D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000378:metabolism; D002452:Cell Count; D015283:Citalopram; D003342:Corpus Striatum / Q000473:pathology*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D015283:Citalopram