title: Role of prostaglandin synthesis inhibitors on chemically induced seizures.
abstract: The study was conducted to find out the possible role of prostaglandin synthesis inhibitors on different parameters of chemically induced seizures in albino mice. The results suggest that prostaglandins have a proconvulsant activity. Augmentation of central dopamine and serotonin levels is partly responsible for the inhibitory effect of prostaglandin synthesis inhibitors on chemically induced seizures.
authors.affiliation: Department of Pharmacology, Banaras Hindu University, Varanasi, India.
authors.forename: J
authors.initials: J
authors.lastname: Bhaduri
authors.forename: D
authors.initials: D
authors.lastname: Hota
authors.forename: S B
authors.initials: SB
authors.lastname: Acharya
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D016861:Cyclooxygenase Inhibitors