title: High dietary chloride content associated with loss of therapeutic serum bromide concentrations in an epileptic dog.
abstract: Bromide treatment was successful in controlling seizures in an 11-year-old Dachshund with epilepsy and presumptive phenobarbital-associated hepatopathy. Because bromide does not induce liver enzyme activity and does not seem to be hepatotoxic, it can be used to control seizures in dogs with concurrent epilepsy and hepatic disease. In this dog, institution of a special calculolytic diet with high chloride content was associated with a decrease in serum bromide concentrations and the recurrence of seizures. High chloride intake increases the elimination of bromide in dogs, leading to higher dosage requirements for bromide in dogs fed high-chloride diets.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: N
authors.initials: N
authors.lastname: Shaw
authors.forename: L A
authors.initials: LA
authors.lastname: Trepanier
authors.forename: S A
authors.initials: SA
authors.lastname: Center
authors.forename: S
authors.initials: S
authors.lastname: Garland
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D001965:Bromides / Q000097:blood / Q000627:therapeutic use*; D002712:Chlorides / Q000008:administration & dosage* / Q000009:adverse effects; D004032:Diet / Q000009:adverse effects / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000378:metabolism*; D004285:Dogs; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D008099:Liver / Q000187:drug effects; D010634:Phenobarbital / Q000009:adverse effects / Q000627:therapeutic use; D017680:Potassium Compounds / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D002712:Chlorides; D017680:Potassium Compounds; C039004:potassium bromide; D010634:Phenobarbital