title: Human obesity does not segregate with the chromosomal regions of Prader-Willi, Bardet-Biedl, Cohen, Borjeson or Wilson-Turner syndromes.
abstract: Prader-Willi, Bardet-Biedl, Cohen, Borjeson and Wilson-Turner syndromes are genetic disorders characterized by obesity and other diverse abnormalities. These disorders have been mapped to their respective chromosomal regions, and we hypothesize that each region contains a gene or genes important in the regulation of body weight. We tested this hypothesis by genotyping sibling pairs (n = 207; 17 markers) from 44 families who were segregating an extreme obesity phenotype but were otherwise clinically normal. The number of alleles shared between siblings from these chromosomal regions did not correlate with similarity in body mass index (kg/m2). If genes in these regions contribute to non-syndromal obesity, the prevalence is low and the corresponding alleles are rare.
authors.affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Reed
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: W
authors.initials: W
authors.lastname: Xu
authors.forename: C
authors.initials: C
authors.lastname: Cather
authors.forename: R A
authors.initials: RA
authors.lastname: Price
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002874:Chromosome Mapping; D002875:Chromosomes / Q000737:chemistry; D004247:DNA / Q000032:analysis; D005192:Family Health; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000235:genetics*; D008607:Intellectual Disability / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics*; D010641:Phenotype; D017689:Polydactyly / Q000150:complications / Q000235:genetics*; D011218:Prader-Willi Syndrome / Q000150:complications / Q000235:genetics*; D011795:Surveys and Questionnaires; D013577:Syndrome
chemical_list: D004247:DNA