The long-acting gonadotropin-releasing hormone analogues impaired the implantation rate.
OBJECTIVE
To determine the efficacy and innocuousness of long-acting versus short-acting GnRH analogues (GnRH-a) in long protocol for in IVF-ET.


METHODS
Prospective randomized study.


METHODS
The IVF unit at an academic hospital.


METHODS
One hundred couples admitted for their first IVF-ET attempt.


METHODS
Serum concentrations of LH, E2, and P during the all cycles and duration of pituitary desensitization were assessed, as well as fertilization rate, embryo quality, and implantation and pregnancy rates.


RESULTS
Significantly more days (10.8 +/- 1.8 versus 9.2 +/- 1.7 days) of stimulation and more ampules of hMG (47 +/- 22 versus 33 +/- 16) were necessary to obtain similar numbers of embryos of quality with the long-acting GnRH-a. Implantation and delivery rates were significantly lower with the long-acting GnRH-a (32.8% versus 21.1%; 48.9% versus 29.1%, respectively).


CONCLUSIONS
As the long-acting GnRH-a might interfere with the luteal phase and embryo development, short-acting GnRH-a should be preferred for ovarian hyperstimulation in IVF-ET.
Devreker
F
F
Free University of Brussels, Belgium.
Govaerts
I
I
Bertrand
E
E
Van den Bergh
M
M
Gervy
C
C
Englert
Y
Y
D000328:Adult; D002064:Buserelin / Q000494:pharmacology*; D018592:Cross-Over Studies; D010064:Embryo Implantation / Q000187:drug effects*; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D017329:Triptorelin Pamoate / Q000494:pharmacology*
D017329:Triptorelin Pamoate; D011374:Progesterone; D004958:Estradiol; D002064:Buserelin