Hyperresponsiveness of granulocytes to anaphylatoxins, C5a and C3a, in Churg-Strauss syndrome.
A 50-year-old man with Churg-Strauss syndrome showed granulocytes (GNLs) which generated more superoxide anion (O2-) than GNLs from healthy subjects following in vitro stimulation with C5a or C3a. Production of O2- subsided as the clinical symptoms improved with steroid treatment. A hyperresponsiveness of GNLs may be involved in this disorder.
Tanaka
T
T
Research Institute for Diseases of the Chest, Kyushu University Faculty of Medicine, Fukuoka.
Abe
M
M
Mitsuyama
T
T
Fukuoka
Y
Y
Sakurada
T
T
Hara
N
N
D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000276:immunology*; D003167:Complement Activation; D015926:Complement C3a / Q000276:immunology*; D015936:Complement C5a / Q000276:immunology*; D004802:Eosinophilia / Q000209:etiology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D015926:Complement C3a; D015936:Complement C5a