Modulation of glutamate release by a kappa-opioid receptor agonist in rodent and primate striatum.
The influence of the kappa-opioid receptor agonist, enadoline, on endogenous glutamate release was investigated in rat and marmoset striatal synaptosomes. Enadoline decreased 4-aminopyridine (2 mM)-stimulated glutamate release (rat: IC50 approximately 8.7 microM, marmoset: IC50 approximately 2.9 microM). The effect of enadoline was reversed by nor-binaltorphimine (5 microM). These data indicate that, in the striatum of the rat and marmoset, kappa-opioid receptor agonists can modulate glutamate release. These findings may have implications for the treatment of Parkinson's disease.
Hill
M P
MP
Division of Neuroscience, School of Biological Sciences, Manchester University, UK.
Brotchie
J M
JM
D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002144:Callithrix; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D001572:Benzofurans; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; D018698:Glutamic Acid; D015761:4-Aminopyridine; C067110:enadoline