Reduction of HIV concentration during acute infection: independence from a specific immune response.
After infection with the human immunodeficiency virus (HIV), the concentration of the virus in the person's plasma increases. The subsequent decrease in concentration a few weeks later was though to result from an HIV-specific immune response. This purported causal relation is investigated with a model of the dynamics of early HIV infection that incorporates no increase in the rate of removal of free virions or virus-infected cells. A pattern of changes in virus concentration similar to that observed in patients is predicted by the model. Thus, the reduction in virus concentration during acute infection may not reflect the ability of the HIV-specific immune response to control virus replication.
Phillips
A N
AN
Department of Primary Care and Population Sciences, Royal Free Hospital School of Medicine, London, UK.
D000208:Acute Disease; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D006801:Humans; D008213:Lymphocyte Activation; D008433:Mathematics; D008954:Models, Biological; D011157:Population Dynamics; D014766:Viremia / Q000276:immunology / Q000821:virology*; D014771:Virion / Q000502:physiology; D017735:Virus Latency; D014779:Virus Replication