title: Ultrastructural findings in the vestibular end-organs of AIDS cases.
abstract: Neurotologic manifestations are apparent in human immunodeficiency virus (HIV) infection, but are poorly understood. Symptoms related to the vestibular system include episodes of vertigo, imbalance, ataxia, and nausea. Although patients present more often with hearing impairment, vestibular complaints are described and electrophysiologic studies indicate vestibular dysfunction in HIV-infected patients. Whether the disease involvement includes the central, or the peripheral nervous system has not been established. Ultrastructural analysis of vestibular end-organs obtained from HIV autopsy cases revealed pathologic changes in the labyrinth wall, the epithelial lining, and the receptor maculae and cristae. Cytologic changes in hair cells included inclusion bodies, viral-like particles, and hair bundle malformations. Epithelial lining cells, supporting cells, and connective tissue cells had inclusions and viral-like particles. These findings are consistent with those of a previous cochlear study demonstrating intracellular viral-like particles with the morphologic characteristics of HIV. Further cytologic evaluation of decalcified temporal bones and immunohistochemical analysis of freshly harvested HIV-infected temporal bones may provide further insight into the pathogenesis of viral-induced hearing loss and vestibular impairment.
authors.affiliation: Department of Otolaryngology, NYU Medical Center, NY 10016, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Pappas
authors.forename: J T
authors.initials: JT
authors.lastname: Roland
authors.forename: J
authors.initials: J
authors.lastname: Lim
authors.forename: A
authors.initials: A
authors.lastname: Lai
authors.forename: D E
authors.initials: DE
authors.lastname: Hillman
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D000328:Adult; D003238:Connective Tissue / Q000648:ultrastructure / Q000821:virology; D018069:Hair Cells, Vestibular / Q000648:ultrastructure*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008875:Middle Aged; D013701:Temporal Bone / Q000648:ultrastructure; D015837:Vestibular Diseases / Q000473:pathology* / Q000821:virology; D014722:Vestibule, Labyrinth / Q000648:ultrastructure* / Q000821:virology