[Changes in the picture of chronic diseases on long-term hemodialysis treatment].
New data published in the literature provided evidence for appearance of an unknown variant of amyloidosis recorded in patients with a 5-15-year history of hemodialysis. Such amyloidosis may result from high blood levels of beta-2-microglobulin unremovable at standard hemodialysis. Even highly permeable membranes which permit beta-2-microglobulin penetration fail to produce negative balance of this metabolite as the procedure stimulates leukocyte activity and, consequently, beta-2-microglobulin production. In spite of the fact that contact of the blood with synthetic materials during hemodialysis is not longer than 3-5 hours, blood elements and endothelial cell metabolism, homeostasis undergo serious alterations. These effects of biocompatibility provoke the condition of enhanced activation similar to chronic inflammation. Thus, we deal with a new phenomenon in the field of hemodialysis. The efforts of investigators should be aimed at studying long-term adaptation of the body which rings atypical picture of chronic diseases.
von Appen
K
K
Ivanovich
P
P
Klinkmann
H
H
Stetsiuk
E
E
D000686:Amyloidosis / Q000097:blood / Q000209:etiology; D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects; D013997:Time Factors; D014118:Toxins, Biological / Q000097:blood; D014511:Uremia / Q000097:blood / Q000150:complications / Q000628:therapy
D014118:Toxins, Biological; C026865:uremia middle molecule toxins
Izmeneniia v kartine khronicheskikh zabolevaniĭ pri dlitel'nom lechenii gemodializom.