title: Nuclear matrix and the cell cycle.
abstract: The facts that the nuclear matrix represents a structural framework of the cell nucleus and that nuclear events, such as DNA replication, transcription, and DNA repair, are associated with this skeletal structure suggest that its components are subject to cell cycle-regulatory mechanisms. Cell cycle regulation has been shown for nuclear lamina assembly and disassembly during mitosis and chromatin reorganization. Little attention has so far been paid to internal nuclear matrix proteins and matrix-associated proteins with respect to the cell cycle. This survey attempts to summarize available data and presents experimental evidence that important metabolic functions of the nucleus are regulated by the transient, cell cycle-dependent attachment of enzymes and regulatory proteins to the nuclear matrix. Results on thymidine kinase and RNA polymerase during the synchronous cell cycle of Physarum polycephalum demonstrate that reversible binding to the nuclear matrix represents an additional level of regulation for nuclear processes.
authors.affiliation: Department of Microbiology, University of Innsburck-Medical School, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Loidl
authors.forename: A
authors.initials: A
authors.lastname: Eberharter
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D004261:DNA Replication; D012321:DNA-Directed RNA Polymerases; D034882:Lamins; D015530:Nuclear Matrix / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D009687:Nuclear Proteins / Q000502:physiology; D016839:Physarum polycephalum
chemical_list: D034882:Lamins; D009687:Nuclear Proteins; D012321:DNA-Directed RNA Polymerases