title: A fatal dothiepin overdose.
abstract: High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (Prothiaden) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature.
authors.affiliation: Institut de Médecine Légale, Strasbourg, France.
authors.forename: V
authors.initials: V
authors.lastname: Cirimele
authors.forename: P
authors.initials: P
authors.lastname: Kintz
authors.forename: A
authors.initials: A
authors.lastname: Tracqui
authors.forename: P
authors.initials: P
authors.lastname: Mangin
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000032:analysis* / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D004308:Dothiepin / Q000032:analysis* / Q000506:poisoning*; D017809:Fatal Outcome; D005554:Forensic Medicine / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry; D006801:Humans; D008297:Male; D011041:Poisoning / Q000097:blood / Q000175:diagnosis
chemical_list: D000929:Antidepressive Agents, Tricyclic; D004308:Dothiepin