title: Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice.
abstract: A slight increase in mean corpuscular hemoglobin (MCH) has been reported in erythrocytes from human fragile X patients. As it is difficult to perform case-controlled studies in patients with fragile X syndrome, we studied MCH in erythrocytes from transgenic mice with an Fmr1 knockout. None of the knockout mice showed increased MCH levels when compared with normal littermates. We conclude that it is unlikely that the FMR1 gene product has an effect on MCH.
authors.affiliation: Department of Medical Genetics, University of Antwerp, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Reyniers
authors.forename: D R
authors.initials: DR
authors.lastname: Van Bockstaele
authors.forename: K
authors.initials: K
authors.lastname: De Boulle
authors.forename: R F
authors.initials: RF
authors.lastname: Kooy
authors.forename: C E
authors.initials: CE
authors.lastname: Bakker
authors.forename: B A
authors.initials: BA
authors.lastname: Oostra
authors.forename: P J
authors.initials: PJ
authors.lastname: Willems
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000097:blood* / Q000235:genetics; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D012016:Reference Values
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D006454:Hemoglobins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human; C497684:Fmr1 protein, mouse