NMR studies of drug-DNA complexes.
The application of high-resolution, multidimensional NMR techniques to the problem of determining the structure of drug-DNA complexes in solution has led to substantial progress in understanding the effect of drugs on DNA at the molecular level. With the development of isotopic labeling methods applied in three- and four-dimensional experiments, we anticipate that more complex drug-DNA systems will become amenable to structural analysis. In addition to implementing these newer techniques, progress will also be made in terms of investigating the structure of drug complexes with more unusual forms of DNA, such as triplexes, quadruplexes, multistranded junctions, and so forth.
Keniry
M A
MA
Research School of Chemistry, Australian National University, Canberra, Australia.
Shafer
R H
RH
D000465:Algorithms; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D003609:Dactinomycin / Q000378:metabolism / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007364:Intercalating Agents; D007554:Isotopes; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D008926:Plicamycin / Q000378:metabolism / Q000494:pharmacology; D011522:Protons; D012984:Software; D012995:Solubility
D007364:Intercalating Agents; D007554:Isotopes; D004364:Pharmaceutical Preparations; D011522:Protons; D003609:Dactinomycin; D004247:DNA; D008926:Plicamycin