The immunomodulatory diversity of the proteins of the transforming growth factor beta (TGF beta) family.
The examination of immunomodulatory properties of oligopeptides derived from two exposed loops (containing thymopentin-like and tuftsin-like sequences, respectively) of the proteins belonging to TGF beta family suggests that the particular species of the TGF beta family should differ distinctly in their influence on the immune response. According to our results obtained from three TGF beta species of mammals, TGF beta 2 should be a strong immunosuppressor, whereas for TGF beta 3 the immunostimulative potency is more probable. TGF beta 1 species would possess both immunosuppressive and immunostimulative potency, residing in two different loops of the protein. The results obtained also suggest that chicken TGF beta 4 should be associated with immunostimulative effects and xenopus TGF beta 5 with immunosuppressive ones.
Wieczorek
Z
Z
Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Słoń
J
J
Kluczyk
A
A
Zbozień
R
R
Stafanowicz
P
P
Siemion
I Z
IZ
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D006462:Hemolytic Plaque Technique; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments; D016305:Thymopentin / Q000737:chemistry; D016212:Transforming Growth Factor beta / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D014405:Tuftsin / Q000737:chemistry
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D009842:Oligopeptides; D010446:Peptide Fragments; D016212:Transforming Growth Factor beta; D016305:Thymopentin; D014405:Tuftsin