Investigation of the impurities found in methamphetamine synthesised from pseudoephedrine by reduction with hydriodic acid and red phosphorus.
The synthesis of methamphetamine from pseudoephedrine via the reduction with hydriodic acid and red phosphorus was studied and the impurities which were generated, along with the methamphetamine, were investigated. Some of the impurities found have been reported previously, while the diastereoisomers of N-methyl-N-(alpha- methylphenethyl)amino-1-phenyl-2-propanone and the cis-cinnamoyl derivative of methamphetamine are reported here for the first time. Further work on the sequence of reactions occurring in this reduction is also reported.
Windahl
K L
KL
School of Chemistry, La Trobe University, Bundoora, Victoria, Australia.
McTigue
M J
MJ
Pearson
J R
JR
Pratt
S J
SJ
Rowe
J E
JE
Sear
E M
EM
D000143:Acids; D000697:Central Nervous System Stimulants / Q000032:analysis* / Q000737:chemistry; D002849:Chromatography, Gas; D004340:Drug Contamination; D004809:Ephedrine / Q000378:metabolism*; D013287:Illicit Drugs / Q000032:analysis* / Q000737:chemistry; D017613:Iodine Compounds; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008694:Methamphetamine / Q000032:analysis* / Q000737:chemistry; D010084:Oxidation-Reduction; D010758:Phosphorus
D000143:Acids; D000697:Central Nervous System Stimulants; D013287:Illicit Drugs; D017613:Iodine Compounds; D010758:Phosphorus; D008694:Methamphetamine; C010466:hydroiodic acid; D004809:Ephedrine