title: Investigation of association between alpha-1 proteinase inhibitor haplotype and endometritis in the thoroughbred mare.
abstract: Failure to inhibit proteinases can lead to excessive tissue damage. The possibility that the severity of endometritis in Thoroughbred mares correlates with the haplotypes of plasma alpha 1-proteinase inhibitor (alpha 1-PI) expressed was investigated in two groups of mares. In mares with pyometritis before treatment, the frequency of the N haplotype, which is already high in the Thoroughbred population, was significantly increased when compared with that in a large published population. In mares with acute endometritis which persisted after treatment followed by sexual rest, the absence of S and T haplotypes was significant, suggesting that, when present, they may have a protective function.
authors.affiliation: Moredun Research Institute, Edinburgh, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Pemberton
authors.forename: H A
authors.initials: HA
authors.lastname: John
authors.forename: S W
authors.initials: SW
authors.lastname: Ricketts
authors.forename: P D
authors.initials: PD
authors.lastname: Rossdale
authors.forename: A M
authors.initials: AM
authors.lastname: Scott
mesh_terms: D000483:Alleles; D000818:Animals; D004716:Endometritis / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D005260:Female; D006239:Haplotypes; D006734:Horse Diseases / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D006736:Horses; D009154:Mutation; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000235:genetics* / Q000502:physiology
chemical_list: D000515:alpha 1-Antitrypsin