[The protective effect of the nerve growth factor on sensory neurons in organotypic culture under the action of diphtheria toxin].
Diphtheria toxin (1.10(-1) - 1.10(-6) Lf/ml) was found to inhibit neurite extension in chick embryo dorsal root ganglia in vitro. If the nerve growth factor (60 ng/ml) was added with the toxin to culture media, the effect of diphtheria toxin was seen to decrease and the neurite outgrowth was compared with control. Protective effect of nerve growth factor estimated by the influence of diphtheria toxin may be used for new principles of diphtheria treatment.
Romaniuk
A V
AV
Davydovskaia
M V
MV
Sorokina
M N
MN
Chalisova
N I
NI
Liudyno
M I
MI
D000818:Animals; D002642:Chick Embryo; D004167:Diphtheria Toxin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005727:Ganglia, Spinal / Q000187:drug effects / Q000648:ultrastructure; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects / Q000648:ultrastructure; D009924:Organ Culture Techniques; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000648:ultrastructure
D004167:Diphtheria Toxin; D009414:Nerve Growth Factors
Protektiruiushchiĭ éffekt faktora rosta nervov na chuvstvitel'nye neĭrony v organotipicheskoĭ kul'ture pri deĭstvii na nee difteriĭnogo toksina.