Potential use of gabapentin and lamotrigine.
Based on the proposed neurotoxic etiology of ALS and possible actions of gabapentin and lamotrigine, there is some reason to hope for a beneficial response when using these agents in patients with ALS. However, because of the lack of evidence supporting this use, the cost of treatment, and the risk of adverse effects, there is no rationale for this use before larger, controlled clinical trials are completed.
Cory
P R
PR
Department of Pharmacy, University of Wisconsin Hospital and Clinics, Madison 53792, USA.
Gidal
B e
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D000085:Acetates / Q000494:pharmacology / Q000627:therapeutic use*; D000588:Amines; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D000077213:Lamotrigine; D014227:Triazines / Q000494:pharmacology / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D015507:Drugs, Investigational; D014227:Triazines; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D000077213:Lamotrigine