title: A comparison of the effect of cochlear perfusion with ouabain on summating potentials and distortion product otoacoustic emissions in the guinea pig.
abstract: In order to investigate whether or not the summating potential (SP) and the 2f1-f2 distortion product otoacoustic emission (DPOAE) are due to related cochlear non-linearities, their behavior was studied in the guinea pig after intracochlear perfusion with ouabain and subsequent rinsing. The SP was evoked with either 4 or 8 kHz tone bursts, and the 2f1-f2 DPOAE was evoked with simultaneous presentations of 6.6 and 8 kHz continuous tones. After ouabain perfusion, DPOAE was dramatically reduced while the SP underwent only a small reduction. After rinsing out the ouabain with artificial perilymph, the DPOAE showed partial recovery while the SP displayed a large and long-lasting increase when compared to its a initial value. These results suggest that the non-linear processes giving rise to the SP and DPOAE are not identical.
authors.affiliation: Department of Otorhinolaryngology, University Hospital, Utrecht, The Netherlands.
authors.forename: S F
authors.initials: SF
authors.lastname: Klis
authors.forename: G
authors.initials: G
authors.lastname: Rebillard
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001307:Auditory Perception / Q000187:drug effects; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006168:Guinea Pigs; D007267:Injections; D010042:Ouabain / Q000008:administration & dosage / Q000494:pharmacology*; D010498:Perilymph / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase