title: [Refractory hypertension--principles of combination therapy].
abstract: "Non response" to treatment of hypertension may have different reasons: it may be "physician-related" ("white coat hypertension"), of "patient related" (poor adherence to prescribed medication, alcohol abuse, obesity) and it may really be a "resistant hypertension". In such cases one should search for a primary disease. If no such disease is found one should--according to the time-factor--wait for several weeks before increasing the dose; later on one should switch to another drug with a different mechanism of action and, if necessary, use a rational combination.
authors.affiliation: Gesellschaft für klinische Pharmakologie, Wien.
authors.forename: G
authors.initials: G
authors.lastname: Hitzenberger
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents
vernacular_title: Die nicht einstellbare Hypertonie--Prinzipien der Kombinationstherapie.