[Expression of tenascin in lymphoid cells and changes in it upon exposure to low doses of x-rays].
The oncofetal protein tenascin was detected in some strains of lymphoid cells: murine myeloma X-63, murine hybridoma MLC-1 and K-48 and T-cell plasmacytoma MOLT-4. This effect was in agreement with the concept that tenascin serves as a marker of cell malignancy; such a concept allows one to use the marker in the studies of X irradiation impact on hybridoma clones. A non-linear correlation was found between the content of tenascin and the irradiation dosage, by using two hybridoma strains. There might be alterations in the expression of tenascin in the cultured lymphoid cells while detecting the genotoxic effect produced by different damaging agents.
Safronova
E E
EE
Lunga
I N
IN
Shishkin
S S
SS
D000818:Animals; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D019063:Tenascin / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D019063:Tenascin
Ekspressiia tenastsina v limfoidnykh kletkakh i ee izmeneniia pod deĭstviem malykh doz rentgenovskogo izlucheniia.