title: Bone-bonding behavior under load-bearing conditions of an alumina ceramic implant incorporating beads coated with glass-ceramic containing apatite and wollastonite.
abstract: Alumina ceramic with a porous surface coated with glass-ceramic containing apatite and wollastonite (AW-GC) was implanted in a state of press-fit under load-bearing conditions in the femoral condylus of the mongrel dog and compared with a non-glass-ceramic-coated alumina ceramic. A trapezoid alumina ceramic implant (7 x 10 x 5 mm) with a lateral recess (0.9 mm deep) coated with alumina ceramic beads (mean diameter, 750 microns) in a single layer was prepared. The alumina ceramic beads were bonded to the alumina ceramic substratum using an identical alumina binder. The thickness of coating was 10-50 microns (mean, 30 microns). The surface of the beads and the substratum of the alumina implant were coated with AW-GC. A pull-out test and histologic examination were performed at 4, 8, and 24 weeks after implantation. The interfacial shear load was significantly increased from 8 to 24 weeks in both groups. The shear load of the glass-ceramic-coated implant was significantly greater than that of the noncoated implant at every stage. The interface shear load of the noncoated implant was 12.13 +/- 2.76 kg at 4 weeks, 13.92 +/- 4.18 kg at 8 weeks, and 24.17 +/- 5.17 kg at 24 weeks after implantation. The interface shear load of the glass-ceramic-coated implant was 17.96 +/- 2.81 kg at 4 weeks, 24.92 +/- 9.87 kg at 8 weeks, and 34.83 +/- 4.12 kg at 24 weeks after implantation. Histologic examination showed more ingrown bone tissue in the glass-ceramic-coated implants. It is suggested that AW-GC stimulated the bone ingrowth.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Kitsugi
authors.forename: T
authors.initials: T
authors.lastname: Yamamuro
authors.forename: Y S
authors.initials: YS
authors.lastname: Chang
authors.forename: Y
authors.initials: Y
authors.lastname: Senaha
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Oka
mesh_terms: D000818:Animals; D001031:Apatites; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D017610:Calcium Compounds; D002516:Ceramics; D004285:Dogs; D004577:Electron Probe Microanalysis; D005269:Femur; D005898:Glass; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis; D019736:Prostheses and Implants; D017640:Silicates
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D017610:Calcium Compounds; D017640:Silicates; C031293:calcium silicate