Caffeine attenuates CNS oxygen toxicity in rats.
We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO2 at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may be used in low doses for protection against hyperoxia-induced seizures.
Bitterman
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Israel Naval Medical Institute, Haifa, Israel.
Schaal
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S
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D005583:Fourier Analysis; D006931:Hyperbaric Oxygenation; D010100:Oxygen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D002245:Carbon Dioxide; D002110:Caffeine; D010100:Oxygen