[Plasma endothelin 1 and its clinical evaluation in asthma].
Plasma endothelin 1 (ET1) was determined by radioimmunoassay in 28 cases of acute attack of asthma (attack group), 23 subjects of non-symptomatic asthma (remission group) and 20 normal volunteers (control group). The results showed that the plasma ET1 in attack group (13.4 +/- 5.2 fmol/ml) was much higher than that in both remission group (8.4 +/- 3.9 fmol/ml, P < 0.01) and control group (6.6 +/- 2.6 fmol/ml, P < 0.01). However, there was no significant difference between remission group and control group. The plasma ET1 level revealed notably negative correlation to PaO2 and FEV1% (r = -0.8257, r = -0.8157, P < 0.01). The results suggested that ET1 probably involved in pathophysiologic process of acute attack of bronchial asthma.
Sun
R
R
Army 404th Hospital, Weihai.
Luo
W
W
Chen
L
L
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000503:physiopathology; D001785:Blood Gas Monitoring, Transcutaneous; D016232:Endothelins / Q000097:blood* / Q000502:physiology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D016232:Endothelins