Epstein-Barr virus genomes in Hodgkin's disease and non-Hodgkin's lymphomas.
Seventeen of 40 cases of Hodgkin's disease (HD) and eight of 46 non-Hodgkin's lymphomas (NHL) were associated with Epstein-Barr virus (EBV) infection, judged by the EBER-1 in situ hybridization (ISH) method. Approximately 40% incidence in HD was comparable to previous reports. Young children and elderly HD patients were more prone to be found EBV positive. Fourteen of 17 HD and two of 8 NHL cases with positive EBER-1 ISH were also positive on LMP-1 immunostaining. EBV might have a role in lymphomagenesis in these cases. The fact that 7 of 8 EBV-related NHL were peripheral T cell lymphoma indicates the necessity of a larger-scale survey on this subject. As the present study revealed four cases with positive LMP-1 immunostaining but negative EBER-1 ISH (1 HD, 3 NHL), LMP-1 alone should not be regarded as a tool to prove EBV infection.
Li
D
D
First Department of Pathology, School of Medicine, Chiba University, Japan.
Oda
K
K
Mikata
A
A
Yumoto
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D016679:Genome, Viral; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000145:classification / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008214:Lymphocytes / Q000473:pathology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*; D014763:Viral Matrix Proteins / Q000032:analysis
D014763:Viral Matrix Proteins