Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A.
Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.
Inskip
A
A
Department of Neurosurgery, North Staffordshire Hospital, Stoke-on-Trent, Staffordshire, U.K.
Elexperu-Camiruaga
J
J
Buxton
N
N
Dias
P S
PS
MacIntosh
J
J
Campbell
D
D
Jones
P W
PW
Yengi
L
L
Talbot
J A
JA
Strange
R C
RC
D001483:Base Sequence; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000378:metabolism; D050981:Erythroid-Specific DNA-Binding Factors; D005091:Exons; D017353:Gene Deletion; D005787:Gene Frequency; D008040:Genetic Linkage; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014157:Transcription Factors / Q000378:metabolism; D050986:YY1 Transcription Factor
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D014157:Transcription Factors; D050986:YY1 Transcription Factor; C494698:YY1 protein, human; D005982:Glutathione Transferase