Random copolymers containing specific ratios of negatively charged and aromatic amino acids bind V3 disulfide loop and neutralize diverse HIV type 1 isolates.
Random copolymers of polyamino acids containing negatively charged and aromatic residues at specific ratios appear to bind HIV type 1 V3 loop and neutralize diverse laboratory isolates. At least the putative heparin binding domain and isoleucine residues in the amino half of V3 are involved in the interactions with these polymers. There are a number of interesting features common between these polymer's modes of binding to the V3 and the protease inhibition drug ABT-538.
Javaherian
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Repligen Corporation, Cambridge, Massachusetts 02139, USA.
McDanal
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D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry; D004563:Electrochemistry; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000187:drug effects*; D015497:HIV-1 / Q000737:chemistry / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000187:drug effects*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D004220:Disulfides; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments; D010455:Peptides; D011108:Polymers