Cobalt(II), nickel(II), and copper(II) complexes of sulfanilamide derivatives: synthesis, spectroscopic studies, and antibacterial activity. Crystal structure of [Co(sulfacetamide)2(NCS)2].
The synthesis and characterization of new coordination compounds of Co(II), Ni(II), and Cu(II) with sulfacetamide (N-[4-(amino-fenil)sulfonil]acetamide) is reported. The complex [Co(sulfacetamide)2(NCS)2] crystallizes in the triclinic space group P-1. The cell dimensions are a = 7.80(2) A, b = 8.327(9) A, c = 9.568(3) A, alpha = 90.5(1) degrees, beta = 90.5(1) degrees, gamma = 97.8(2) degrees, V = 616(1) A3, Z = 2, and Dx = 1.689 g/cm3. The final conventional R-factor = 0.039 (Rw = 0.039) for 3535 "observed" reflections and 173 variables. The Co(II) is surrounded in a regular octahedral arrangement by two Nthyocianato from the NCS, two Namino and two Oacetamido atoms from the sulfacetamide. Each sulfacetamide, acting as a bidentate ligand, chelates two Co(II) ions as a bridge through the Namino and the Oacetamido atoms. IR, Reflectance Diffuse, EPR, and magnetic properties of the obtained complexes are discussed. The complexes were screened for their activity against E. Coli and S. aureus, showing an appreciable antimicrobial activity compared with the ligands.
Blasco
F
F
Departamento de Química Inorgánica, Universidad de Valencia, Spain.
Perelló
L
L
Latorre
J
J
Borrás
J
J
Garciá-Granda
S
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013424:Sulfanilamides / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013424:Sulfanilamides; D003035:Cobalt; D003300:Copper; D009532:Nickel