Effects of nonsteroidal antiinflammatory drugs on renal plasma flow and glomerular filtration rate in patients with glomerulonephritis.
We investigated the effects of NSAIDs (Ibuprofen) on renal plasma flow (RPF) and glomerular filtration rate (GFR) in patients with glomerulonephritis. The study included 98 patients (53 men and 45 women) with idiopathic glomerulonephritis. All of the patients received Ibuprofen 1200 mg (3x400) during 7 days. Before and after the treatment with Ibuprofen ERPF (clearance of 131I-Hippuran) and GFR (clearance of 99mTc-DTPA) were determined. In our patients administration of Ibuprofen was associated with a significant reduction in renal plasma flow and glomerular filtration rate. In patients with reduced renal function the decrease in RPF and GFR after Ibuprofen was significantly greater than in patients with normal renal function.
Stosić
Z
Z
Department of Nephrology and Clinical Immunology, Faculty of Medicine, Novi Sad.
Sedlak
V
V
Curić
S
S
Fellé
D
D
Budakov
P
P
Tepavcević
P
P
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D005921:Glomerulonephritis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D017596:Renal Plasma Flow, Effective / Q000187:drug effects*; D016284:Technetium Tc 99m Pentetate
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D016284:Technetium Tc 99m Pentetate; D007052:Ibuprofen