Signalling in extracellular-matrix-mediated control of epithelial cell phenotype.
Interactions with an appropriate ECM are crucial for normal cell behaviour. The basement membrane contributes to both the tissue-specific lactational function and survival of mammary epithelial cells, possibly through a similar beta 1-integrin-dependent mechanism. Of current interest is whether the downstream intracellular signals diverge, with milk expression regulated through cell shape and the Jak-Stat pathway and survival mediated through controls on the Bcl-2/Bax and Ice checkpoints.
Edwards
G
G
School of Biological Sciences, Univerisity of Manchester, U.K.
Streuli
C
C
D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D002454:Cell Differentiation; D002470:Cell Survival; D004847:Epithelial Cells; D005109:Extracellular Matrix / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000254:growth & development / Q000502:physiology; D051379:Mice; D010641:Phenotype; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology*