Primary prevention in patients with coronary heart disease: the APSIS study.
Symptomatic treatment of patients with angina pectoris is well established and consists of nitrates, calcium antagonists, or beta-blockers. All these drugs improve symptomatology and reduce signs of ischemia on exercise test or long-term electrocardiogram recordings. It is not known, however, whether these drugs also improve prognosis. The only drug shown to improve prognosis is aspirin. In order to study the prognostic effect of calcium antagonists and beta-blockers, these two drugs were compared in the APSIS study.
Rehnqvist
N
N
Department of Medicine, Danderyd Hospital, Sweden.
Hjemdahl
P
P
Björkander
I
I
Eriksson
S V
SV
Forslund
L
L
Held
C
C
Wallén
H
H
Billing
E
E
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000787:Angina Pectoris / Q000150:complications; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003327:Coronary Disease / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D014665:Vasodilator Agents / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D014700:Verapamil; D008790:Metoprolol