[Effect of 1-alpha blockader on maximal oxygen consumption and physical endurance in hypertensive men].
The effect of alpha 1 adrenoceptor blockade (doxazosin, 4 mg daily) on maximal oxygen uptake (VO2 max) and physical endurance capacity in 16 mildly hypertensive, athletic men was investigated in a randomized, placebo-controlled, double-blind, two-period of 4 weeks, cross-over study. The maximal work load obtained during graded bicycle ergometer exercise and the VO2 max were reduced by 16 +/- 3 W (mean +/- SE) and 3 +/- 1 ml x kg-1 x min-1 on doxazosin (p < 0.001 for both), and the running time on 5000 m track increased by 43 +/- 12 sec (p < 0.05). Thus, alpha 1-blockade moderately reduces VO2 max and physical endurance capacity in mildly hypertensive athletic men. However, lower systolic blood pressure (9 +/- 4 mm Hg, p < 0.05) immediately after running, and unchanged heart rate suggest a safer performance of exercise.
Tomten
S E
SE
Norsk idrettsmedisinsk institutt, Oslo.
Nilsson
S
S
Kjeldsen
S E
SE
Westheim
A S
AS
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D017292:Doxazosin / Q000008:administration & dosage*; D005080:Exercise Test; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D010807:Physical Endurance / Q000187:drug effects*; D012420:Running
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D017292:Doxazosin
Effekt av alpha 1-blokade på maksimalt oksygenopptak og fysisk utholdenhet hos hypertensive menn.