title: MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4.
abstract: Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I-selected CD4-CD8-TCR alpha beta+ T cells, potentially implicated in the development of specific Th2 immune cells, is reviewed.
authors.affiliation: Université René Descartes, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Leite-de-Moraes
authors.forename: M
authors.initials: M
authors.lastname: Dy
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation; D005805:Genes, MHC Class I / Q000502:physiology*; D015847:Interleukin-4 / Q000502:physiology*; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000502:physiology*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D015847:Interleukin-4