title: Persistence of bovine herpesvirus-1-specific antibodies in cattle after intranasal vaccination with a live virus vaccine.
abstract: To study the development and persistence of circulating antibodies directed against bovine herpesvirus-1 (BHV-1) induced by vaccination, approximately 80 per cent of the seronegative cows in four partly seronegative dairy herds were vaccinated once with a temperature-sensitive live virus vaccine. Most (83 per cent) of the vaccinated animals developed antibodies to BHV-1 within two months after the vaccination. In the same period, 21 per cent of the unvaccinated control cattle also seroconverted, suggesting that the vaccine virus had been transmitted to them. Thirty months after they had been vaccinated 91 per cent of the vaccinated animals which responded still had detectable antibodies. The results suggest that vaccine-induced antibodies may persist for years and thus may interfere with control programmes for BHV-1 which are based on serological monitoring.
authors.affiliation: Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: W H
authors.initials: WH
authors.lastname: Van der Poel
authors.forename: J A
authors.initials: JA
authors.lastname: Kramps
authors.forename: J
authors.initials: J
authors.lastname: Quak
authors.forename: A
authors.initials: A
authors.lastname: Brand
authors.forename: J T
authors.initials: JT
authors.lastname: Van Oirschot
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000517:prevention & control; D003612:Dairying; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines