title: Clomipramine treatment for stereotype and related repetitive movement disorders associated with mental retardation.
abstract: The efficacy of the serotonin uptake inhibitor clomipramine in the treatment of stereotyped and related repetitive behavior disorders was tested in individuals with severe and profound mental retardation. A double-blind, placebo-controlled crossover trial of clomipramine was associated with significant reductions in the frequency and intensity of stereotyped behavior and teacher ratings of stereotypy, hyperactivity, and irritability as well as increased adaptive engagement and decreased staff intervention for nontargeted behavior problems. Adverse effects occurred in 3 of the 10 subjects. Of the 7 subjects who tolerated the drug, 6 exhibited a clinically significant improvement in one or more repetitive behaviors. Our results provide support for the hypothesis that clomipramine is effective in treating stereotyped and related behaviors associated with mental retardation.
authors.affiliation: Department of Psychiatry, University of Florida, Gainesville 32610, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Lewis
authors.forename: J W
authors.initials: JW
authors.lastname: Bodfish
authors.forename: S B
authors.initials: SB
authors.lastname: Powell
authors.forename: R N
authors.initials: RN
authors.lastname: Golden
mesh_terms: D000293:Adolescent; D000328:Adult; D002997:Clomipramine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D008297:Male; D009069:Movement Disorders / Q000150:complications* / Q000188:drug therapy*; D010919:Placebos; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013239:Stereotyped Behavior; D016896:Treatment Outcome
chemical_list: D002997:Clomipramine; D010919:Placebos; D017367:Selective Serotonin Reuptake Inhibitors