Nafcillin-associated hepatotoxicity. Report of a case and review of the literature.
Nafcillin is a semisynthetic penicillin that is generally well tolerated with few side effects. Hepatic complications are rare but have a potential for serious liver dysfunction. This unusual complication causes a predominantly cholestatic injury, which can persist for prolonged periods even after discontinuing the medication. The pathophysiology may include direct cytotoxicity or an immune-mediate hypersensitivity. Treatment is generally supportive, except for severely symptomatic patients who may require steroids. We report a case of nafcillin-associated hepatotoxicity and review the literature of this disorder.
Presti
M E
ME
Department of Pathology, Saint Louis University Health Sciences Center, Missouri 63110, USA.
Janney
C G
CG
Neuschwander-Tetri
B A
BA
D056486:Chemical and Drug Induced Liver Injury; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008875:Middle Aged; D009254:Nafcillin / Q000009:adverse effects*
D009254:Nafcillin