Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock.
Brain interleukin-1 (IL-1) plays a key role in mediating the neural, endocrine, and behavioral consequences of injury and infection. Recent evidence indicates that brain IL-1 may also be important in producing endocrine and neurochemical responses to stressors. The present experiment sought to determine whether intracerebroventricular (i.c.v.) administration of an interleukin-1 receptor antagonist (IL-1ra) would block behavioral effects of a stressor. I.c.v. application of hrIL-1ra before inescapable shock blocked the subsequent interference with escape learning and enhancement of fear conditioning normally produced by this treatment.
Maier
S F
SF
Neuroscience & Behavior Program, University of Colorado, Boulder 80309-0345, USA.
Watkins
L R
LR
D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects*; D005239:Fear / Q000187:drug effects*; D006380:Helplessness, Learned; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000523:psychology
D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins