title: Cardiovascular response to mental stress in offspring of hypertensive parents: the Dutch Hypertension and Offspring Study.
abstract: OBJECTIVE
  To compare blood pressure-regulating mechanisms during mental stress in two groups of offspring with contrasting risk for hypertension.
  
  
  METHODS
  Cardiovascular reactivity to two different types of mental stressors was studied in adolescents and young adults with two hypertensive or two normotensive parents. The two tasks used were intended to evoke either a predominantly adrenergic cardiac response (a memory search task) or a predominantly vascular response (a reaction-time task with visual search and tone avoidance).
  
  
  METHODS
  Blood pressure and heart rate were recorded at rest and during stress. To study adaptations of the cardiovascular system to mental stress, cardiac output, total peripheral resistance and indices of vagal and sympathetic influences on the heart were measured.
  
  
  RESULTS
  The reactivity of systolic blood pressure (SBP) to the memory search task was significantly higher in offspring of hypertensive parents, which resulted in a longer recovery after the task. In contrast, during the reaction-time task, offspring of hypertensive parents had a significantly enhanced reactivity of peripheral resistance, but no differences in heart rate or blood pressure response were observed. No differences between the two groups were found in sympathetic or vagal activity during either task measured by the ratio of pre-ejection time and left ventricular ejection time, and respiratory sinus arrhythmia, respectively.
  
  
  CONCLUSIONS
  Apart from a higher reactivity of SBP during the memory search task, no other indications supporting the presence of hyperadrenergic activation of the heart in early primary hypertension were found. On the contrary, the results of the present study support the hypothesis that blood pressure responses in prehypertensive subjects are characterized by enhanced vasoconstriction rather than by increased cardiac output.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: D C
authors.initials: DC
authors.lastname: de Visser
authors.forename: I M
authors.initials: IM
authors.lastname: van Hooft
authors.forename: L J
authors.initials: LJ
authors.lastname: van Doornen
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: J F
authors.initials: JF
authors.lastname: Orlebeke
authors.forename: D E
authors.initials: DE
authors.lastname: Grobbee
mesh_terms: D000293:Adolescent; D000328:Adult; D002319:Cardiovascular System / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D011930:Reaction Time; D013315:Stress, Psychological / Q000503:physiopathology*