title: [Structural-functional features of factor VIII (FVIII) and its role in the cascade system of blood coagulation].
abstract: Functions and structure of FVIII which is a cofactor in the internal way of blood coagulation are described as well as the known activation and inactivation mechanisms of FVIII following from its domain structure. The effect exerted by the Willibrandt factor (Wf), thrombin, factor X alpha(FX), activated protein C(APC) on the FVIII functions and interrelation between internal and external ways of blood coagulation in FVIII activation are discussed. The homologous structure of factors V and VIII which is a result of their cofactor action is described.
authors.forename: A E
authors.initials: AE
authors.lastname: Gutsalo
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000502:physiology; D005169:Factor VIII / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D011486:Protein C / Q000502:physiology; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000502:physiology; D014841:von Willebrand Factor / Q000737:chemistry / Q000502:physiology
chemical_list: D001779:Blood Coagulation Factors; D011486:Protein C; D014841:von Willebrand Factor; D005169:Factor VIII; D013917:Thrombin
vernacular_title: Strukturno-funktsional'nye osobennosti faktora VIII (FVIII) i ego rol' v kaskadnoĭ sisteme svertyvaniia krovi.