Two-sample rank tests for acceleration in cure models.
I derive the locally most powerful rank tests for acceleration against semi-parametric alternatives when some patients are cured of the disease. I consider some particular classes of alternatives and present simulation results to verify the validity of the proposed tests. Real data from clinical trials for childhood leukaemia illustrate the proposed tests.
Lee
J W
JW
Department of Statistics, Korea University, Seoul, Korea.
D002648:Child; D003198:Computer Simulation; D018572:Disease-Free Survival; D006801:Humans; D016015:Logistic Models; D008297:Male; D015233:Models, Statistical; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D016016:Proportional Hazards Models; D012008:Recurrence; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors