title: Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.
abstract: A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H]quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced dementia) as potential agents for the treatment of Alzheimer's disease. Compounds displaying significant activity were more broadly evaluated, which revealed the presence of a desirable adrenergic component of activity. The synthesis and structure-activity relationships for this series is presented, along with the biological profiles of selected compounds.
authors.affiliation: Hoechst-Roussel Pharmaceuticals Inc., Somerville, New Jersey 08876, USA.
authors.forename: L
authors.initials: L
authors.lastname: Davis
authors.forename: G E
authors.initials: GE
authors.lastname: Olsen
authors.forename: J T
authors.initials: JT
authors.lastname: Klein
authors.forename: K J
authors.initials: KJ
authors.lastname: Kapples
authors.forename: F P
authors.initials: FP
authors.lastname: Huger
authors.forename: C P
authors.initials: CP
authors.lastname: Smith
authors.forename: W W
authors.initials: WW
authors.lastname: Petko
authors.forename: M
authors.initials: M
authors.lastname: Cornfeldt
authors.forename: R C
authors.initials: RC
authors.lastname: Effland
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000037:antagonists & inhibitors / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D011813:Quinuclidinyl Benzilate / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001679:Biogenic Amines; D011725:Pyridines; D011813:Quinuclidinyl Benzilate