[Epidemiological risk assessment for chemical substances].
Epidemiological risk assessment for chemicals is usually based on analytical studies like case-control or cohort studies. Both study types have a number of specific advantages and disadvantages which are outlined. The evaluation of a substance is done on the basis of the results of these studies either qualitatively or quantitatively. For quantitative risk assessment reliable data are needed for the dose of the substance to which the individuals in the study were exposed. For a number of chemical sufficient data are available. Among these are experimental pollutants like arsenic, benzene or radon. As an example the possibilities of risk assessment for dioxin are outlined. The knowledge on the carcinogenicity of dioxin has significantly improved during the last years. Some research groups currently use data of a number of cohort studies to perform a quantitative risk assessment.
Becher
H
H
Deutsches Krebsforschungszentrum, Abteilung Epidemiologie, Heidelberg.
Wahrendorf
J
J
D002273:Carcinogens; D016022:Case-Control Studies; D015331:Cohort Studies; D004785:Environmental Pollutants; D004812:Epidemiologic Methods; D005858:Germany; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D000072317:Polychlorinated Dibenzodioxins; D018570:Risk Assessment
D002273:Carcinogens; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins
Epidemiologische Risikobewertung chemischer Stoffe.