[The stress-protective effect of fenazepam in rats with different capacities for escape in an acute aversive situation].
Stress-protective effect of phenazepam (1 mg/kg) was studied in rats with different ability to avoid acute aversive situation. Two types of extreme situations were created, immobilization and hyperkinesia (permanent running inside the wheel). It was found out that rats which easily avoided acute aversive situation (I group) were more resistant to extreme effects. In immobilization stress phenazepam produced protective effect mostly in rats with low ability to avoid acute stress situation (II group). In situation with hyperkinesia the drug did not essentially influence the state of rats of the II group and even aggravated the state of rats of the I group. It seems likely that stress resistance of animals and dissimilar protective effects of phenazepam are determined by distinctions in coping mechanisms.
Ostrovskiĭ
O V
OV
Spasov
A A
AA
D000208:Acute Disease; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D006948:Hyperkinesis / Q000503:physiopathology; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Izuchenie stress-protektivnogo vliianiia fenazepama na krys s razlichnoĭ sposobnost'iu k izbavleniiu v ostroĭ aversivnoĭ situatsii.