Structural analysis of antiviral sulfated alpha-D-(1-->3)-linked mannans.
The structures of two alpha-(1-->3)-alpha-D-xylo-mannans were determined. The different antiviral activity of the xylo-mannans from Nothogenia fastigiata was explained on the basis of a flexible backbone, molecular size, content and distribution of sulfate groups and of the single stubs of beta-(1-->2)-linked D-xylose.
Kolender
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AA
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Matulewicz
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MC
Cerezo
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AS
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002236:Carbohydrate Conformation; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008351:Mannans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008745:Methylation; D008970:Molecular Weight; D009005:Monosaccharides / Q000032:analysis; D009904:Optical Rotation; D012624:Seaweed / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013463:Sulfuric Acid Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014994:Xylose / Q000737:chemistry
D000998:Antiviral Agents; D008351:Mannans; D009005:Monosaccharides; D013463:Sulfuric Acid Esters; D014994:Xylose