Size variation of the major immunodominant protein of Cowdria ruminantium.
An immunodominant response is made to a polypeptide of approximately 32 kDa in animals infected with the rickettsial pathogen Cowdria ruminantium. We show here using cultured strains of the rickettsia from different geographical areas that the apparent size of this polypeptide varies with strain origin. Changes in the primary structure between strains should be considered in the design of vaccines and diagnostic tests based on this antigen.
Barbet
A F
AF
Department of Infectious Diseases, University of Florida, Gainesville 32611-0880, USA.
Semu
S M
SM
Chigagure
N
N
Kelly
P J
PJ
Jongejan
F
F
Mahan
S M
SM
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D003429:Cross Reactions; D004285:Dogs; D016995:Ehrlichia ruminantium / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006357:Heartwater Disease / Q000175:diagnosis / Q000276:immunology; D016056:Immunodominant Epitopes / Q000276:immunology*; D008970:Molecular Weight; D011817:Rabbits; D012698:Serologic Tests; D012756:Sheep
D000942:Antigens, Bacterial; D016056:Immunodominant Epitopes