P1 blood group antigen expression and epidemic hemolytic uremic syndrome.
P1 blood group positivity has been postulated as a host factor which may provide protection against the development of post-enteropathic hemolytic uremic syndrome (HUS). In this study, blood group status in 20 Inuit survivors of Escherichia coli O157:H7-associated HUS was compared with age- and sex-matched controls from the same community who had experienced uncomplicated diarrheal illness due to the same pathogen. Of 20 HUS survivors, 6 were P1 antigen positive compared with 8 of the 20 controls (P = 0.7). We conclude that P1 antigen positivity was not protective against HUS in this population. Further studies of this condition to clarify the role of host factors in verotoxin-induced endothelial damage are indicated.
Orr
P H
PH
Department of Community Health Sciences, University of Manitoba, Canada.
Dong
V
V
Schroeder
M L
ML
Ogborn
M R
MR
D000368:Aged; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000097:blood*; D001427:Bacterial Toxins / Q000097:blood*; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004768:Enterotoxins / Q000097:blood*; D004926:Escherichia coli; D005260:Female; D005500:Follow-Up Studies; D005759:Gastroenteritis / Q000150:complications* / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D006463:Hemolytic-Uremic Syndrome / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D009687:Nuclear Proteins / Q000097:blood*; D022622:Shiga Toxin 1
D034961:Antigens, Nuclear; D001324:Autoantigens; D001427:Bacterial Toxins; D004768:Enterotoxins; D009687:Nuclear Proteins; D022622:Shiga Toxin 1