Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection.
Portmann
G A
GA
Sanofi Research Division, Collegeville, PA 19426, USA.
Simmons
D M
DM
D000726:Androgen Antagonists / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry*; D000818:Animals; D004285:Dogs; D007275:Injections, Intravenous; D007555:Isoxazoles / Q000008:administration & dosage* / Q000032:analysis* / Q000097:blood / Q000737:chemistry*; D010069:Oxadiazoles / Q000032:analysis* / Q000097:blood / Q000737:chemistry*; D011278:Pregnanes / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry*; D011720:Pyrazoles / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry*; D012995:Solubility; D013777:Tetrazoles / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry*
D000726:Androgen Antagonists; D007555:Isoxazoles; D010069:Oxadiazoles; D011278:Pregnanes; D011720:Pyrazoles; D013777:Tetrazoles; C098042:WIN 61605; C098039:WIN 63843; C060492:zanoterone