title: Major histocompatibility complex class II I-E-independent transmission of C3H mouse mammary tumor virus.
abstract: C57BL/6 mice are resistant to C3H mouse mammary tumor virus (MMTV)-induced mammary tumorigenesis and lack major histocompatibility complex class II I-E molecules that are essential for presentation of C3H superantigen to T cells. T cells are needed for transmission of milk-borne MMTV from the gut to the mammary gland. In this report, we show that infectious C3H MMTV is produced by C57BL/6 mice that nurse on C3H mothers but that virus production in the mammary gland is delayed compared with that in I-E+ mouse strains.
authors.affiliation: Department of Microbiology, University of Texas at Austin 78712, USA.
authors.forename: T
authors.initials: T
authors.lastname: Wrona
authors.forename: J P
authors.initials: JP
authors.lastname: Dudley
mesh_terms: D000818:Animals; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D012192:Retroviridae Infections / Q000276:immunology / Q000635:transmission*; D014412:Tumor Virus Infections / Q000276:immunology / Q000635:transmission*
chemical_list: D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta