[Normolipemic plane xanthoma, monoclonal gammopathy, anti-lipoprotein activity, hypocomplementemia].
BACKGROUND
Normolipaemic plane xanthomatosis is classically associated with a monoclonal gammapathy.


METHODS
We observed this association in a 69-year-old woman. This case was particular since anti-lipoprotein activity due to a monoclonal IgG immunoglobulin was found in the serum with abnormal complement fractions. The paraproteinaemia remained stable after a 2-year follow-up.


CONCLUSIONS
This association is remarkable. The anti-lipoprotein activity of the monoclonal protein should be emphasized in light of the immunological processes involved in the pathogenesis of this association.
Modiano
P
P
Service de Dermatologie, Hôpital Fournier, Nancy.
Gillet-Terver
M N
MN
Reichert
S
S
François-Griffaton
A
A
Beaumont
J L
JL
Weber
M
M
Schmutz
J L
JL
D000368:Aged; D003165:Complement System Proteins / Q000172:deficiency*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000276:immunology*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications*; D014973:Xanthomatosis / Q000097:blood / Q000150:complications*
D007074:Immunoglobulin G; D008055:Lipids; D008074:Lipoproteins; D003165:Complement System Proteins
Xanthomes plans normolipémiques, gammapathie monoclonale, activité antilipoprotéine, hypocomplémentémie.