Central effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) in mice.
The central effects of endothelin-1 (ET-1, 0.5, 1, 2.5 and 10 pmol/mouse) and endothelin-3 (ET-3, 2.5, 5, 10, 20 and 25 pmol/mouse) have been studied after intracerebroventricular (i.c.v.) administration in mice. The following methods were used: behavioral observations, rotarod, spontaneous and amphetamine-stimulated motor activity, and hexobarbital-induced narcosis. ET-1 and ET-3 evoked a dose-dependent behavioral syndrome with a short excitatory period in the higher doses lasting for 5-10 min, followed by a prolonged depressive phase (about 90 min). ET-1 and ET-3 produced central depressive effects demonstrated by depressive behavior signs, decrease of the spontaneous and amphetamine-stimulated motor activity, and prolongation of the hexobarbital-induced narcosis.
Maslarova
J
J
Chemical Pharmaceutical Research Institute, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Getova
D
D
Semkova
I
I
Nikolov
R
R
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003198:Computer Simulation; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects
D016232:Endothelins; D000661:Amphetamine