Pulmonary function changes induced by three regimens of bronchodilating agents in calves with acute respiratory distress syndrome.
Two aerosolised bronchodilators, one sympathomimetic and one parasympatholytic, were tested either alone or in combination for their ability to improve the pulmonary function of double-muscled calves suffering from acute respiratory distress syndrome. In control animals treated with 0.9 per cent saline the parameters of pulmonary function and signs of clinical distress did not change significantly within the hour following the first treatment. Among the other animals, both at one hour and seven days after the first treatment, the most clinical improvement was observed in the animals treated with both bronchodilators and the least in the animals treated with clenbuterol hydrochloride. One hour after the first treatment the respiratory system compliance of the animals treated with ipratropium bromide and the arterial oxygen tension of the animals treated with both bronchodilators were significantly enhanced. After seven days the resistive parameters, the rectal temperature and the respiratory rate were also significantly improved in the animals treated with ipratropium bromide or both bronchodilators whereas only the respiratory rate and rectal temperature were significantly reduced in the animals treated with clenbuterol hydrochloride.
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Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liège, Belgium.
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Lindsey
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Lekeux
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D000208:Acute Disease; D000336:Aerosols; D000818:Animals; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000503:physiopathology; D002976:Clenbuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D009241:Ipratropium / Q000008:administration & dosage / Q000627:therapeutic use*; D009330:Nebulizers and Vaporizers / Q000662:veterinary; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests / Q000662:veterinary; D012131:Respiratory Insufficiency / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D013566:Sympathomimetics / Q000008:administration & dosage / Q000627:therapeutic use
D000336:Aerosols; D001993:Bronchodilator Agents; D010276:Parasympatholytics; D013566:Sympathomimetics; D009241:Ipratropium; D002976:Clenbuterol