Changes in serotonin-immunoreactivity in the dorsal and median raphe nuclei of rats exposed to 2,4-dichlorophenoxyacetic acid through lactation.
Comparison of serotonin-immunoreactive (SER-IR) neurons in nucleus raphe dorsalis (NRD) and median raphe nucleus (MRN) of 25-d-old rat pups exposed to 70 mg/kg/d 2,4-dichloro-phenoxyacetic acid through mothers milk and control pups was made using an immunohistochemical analysis. Significant 2,4-D-treatment-related increase in size and density of SER-IR neuronal somata as well as in fiber length were observed. We postulate that exposure to 2,4-dichlorophenoxyacetic acid on the first day of life would modify the synthesis of 5-HT or the maturation of the brain serotonergic system.
Evangelista de Duffard
A M
AM
Experimental Toxicology Laboratory, School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Argentine Republic.
Brusco
A
A
Duffard
R
R
García
G
G
Pecci Saavedra
J
J
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D002452:Cell Count / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D007124:Immunoenzyme Techniques; D007774:Lactation; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry / Q000187:drug effects*; D009474:Neurons / Q000737:chemistry / Q000187:drug effects*; D011903:Raphe Nuclei / Q000737:chemistry* / Q000166:cytology / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012701:Serotonin / Q000032:analysis*
D015084:2,4-Dichlorophenoxyacetic Acid; D012701:Serotonin