title: Antigen-independent reactivation of anti-E, years after allogeneic bone marrow transplantation: a case report.
abstract: Nine years after allogenic bone marrow transplantation a strong anti-E was observed in a patient transplanted with bone marrow from his HLA-identical brother. This IgG anti-E, with a titre of 4000, was detected together with autoantibodies to red blood cells and platelets and was not induced by transfusion with E+ cells. The hypothesis is proposed that the anti-E represents either antigen-independent desuppression of the donor immune system sensitized at the time of bone marrow transplantation by E antigens in the recipient, or antigen-independent memory B-cell activation by Epstein-Barr virus infection.
authors.affiliation: Department of Transfusion Medicine, University Hospital, Tübingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Wernet
authors.forename: B
authors.initials: B
authors.lastname: Weiss
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Northoff
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D012203:Rh Isoimmunization; D014184:Transplantation, Homologous
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G