Carbamazepine and cocaine-cue reactivity.
Subjective and electroencephalographic reactions to cocaine cues were evaluated in 33 cocaine-dependent out-patients and 17 non-cocaine-dependent controls. Subjective, EEG, and autonomic reactions to three 5-min videos (cocaine-associated, erotic, neutral) were evaluated twice with an interpolated 1-week interval. Between evaluations, cocaine-dependent patients received carbamazepine 400 mg daily or matching placebo in double-blind fashion. In all three groups the cocaine-associated and erotic videos produced a comparable increase in the self-rated desire for cocaine and reduction in total EG power. Carbamazepine treatment increased EEG fast alpha power and self-rated fatigue, and decreased self-rated concentration and vigor. However, it had no specific effect on subjective or physiological reactivity to either the cocaine-associated or erotic videos. This negative finding is consistent with recent clinical trials of carbamazepine for cocaine dependence.
Hersh
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Department of Psychiatry, University of Connecticut Health Center, Farmington 06030, USA.
Bauer
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Kranzler
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HR
D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects; D001143:Arousal / Q000187:drug effects*; D002220:Carbamazepine / Q000008:administration & dosage* / Q000009:adverse effects; D002540:Cerebral Cortex / Q000187:drug effects; D003042:Cocaine; D003463:Cues; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D012815:Signal Processing, Computer-Assisted; D013375:Substance Withdrawal Syndrome / Q000523:psychology / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
D018712:Analgesics, Non-Narcotic; D002220:Carbamazepine; D003042:Cocaine