Flow-injection spectrofluorimetric determination of flufenamic and mefenamic acid in pharmaceuticals.
Two sensitive and rapid flow-injection (FI) spectrofluorimetric methods are proposed for the determination of flufenamic acid (FF) and mefenamic acid (MF), based on the formation of complexes of these compounds with A1(III) in an ethanolic medium. The calibration graphs resulting from the measurements of the fluorescence at lambda exc = 351 nm and lambda em = 440 nm, and lambdaexc = 355 nm and lambda em = 454 nm for the complexes with FF and MF, respectively, are linear over the range 0.030-1.20 micrograms ml-1 for FF and 0.30-16.1 micrograms ml-1 for MF. The methods have been applied to the determination of these drugs in pharmaceutical preparations.
Albero
M I
MI
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Sanchez-Pedreño
C
C
Garcia
M S
MS
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000032:analysis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002138:Calibration; D004347:Drug Interactions; D000431:Ethanol / Q000737:chemistry; D017022:Flow Injection Analysis; D005439:Flufenamic Acid / Q000032:analysis* / Q000737:chemistry; D008528:Mefenamic Acid / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008528:Mefenamic Acid; D000431:Ethanol; D005439:Flufenamic Acid