Platelet count and platelet factor 3 (PF-3) availability in sickle cell disease.
In view of the effect of red blood cell membrane on platelet factor 3 release in sickle cell disease, platelet count and platelet factor 3 (PF-3) availability were measured in 30 sickle cell patients in a stable state and 15 with thrombocytosis, and these were compared with 60 non-sickle cell individuals as controls. There were no significant differences in platelet counts, but there was a slightly higher PF-3 availability in sickle cell patients not in crisis than in the controls (P < 0.025). Sickle cell patients with thrombocytosis made PF-3 available more readily than did the control individuals and sickle cell patients not in crisis (P < 0.001). We conclude that sickle cell patients are capable of making platelet factor 3 readily available for coagulation activation, and this may play a decisive role in vaso-occlusive crisis.
Famodu
A A
AA
Department of Haematology, Faculty of Medicine, University of Benin, Nigeria.
Oduwa
D
D
D000755:Anemia, Sickle Cell / Q000097:blood*; D006801:Humans; D010976:Platelet Count; D010977:Platelet Factor 3 / Q000032:analysis*; D013922:Thrombocytosis / Q000097:blood
D010977:Platelet Factor 3