Physical chemistry and the biologic week in the perspective of chrono-oncology.
The computation of spectra and cross-spectra yielding coherences suggests that there exist certain relationships between rhythmicities and electromagnetic fields that are external to the biologic structure studied. Models are here provided which may prompt further investigation by allowing at least tentative, quantitative temporal insights into physico-chemical aspects of the biologic week. On the basis of empirical data, a computation of the oscillating frequency during the diffusion of ions in a magnetic field can be performed. The frequency of some ions found in cells (Ca2+, K+, Na+, Mg2+) and of some proteins (albumin, hemoglobin) can be calculated given the diffusion constant in cells, the magnetic field strength, the relative molecular mass and the effective charge. For a field of 10(-9) Tesla, the oscillating period of K+ is about 180 hours, that of Ca2+ about 160 hours, that of Na+ about 150 hours and that of Mg2+ about 145 hours; the period lengths of albumin and hemogiobin are of the order of 30 and 40 days. Without a consideration of any receptors, the results seem to represent, at least numerically, realistic components in the time structure investigated by chronobiology.
Ulmer
W
W
Biophysics Institute, University of Göttingen, Germany.
Cornélissen
G
G
Halberg
F
F
D001774:Blood Chemical Analysis; D002909:Chronobiology Phenomena / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D008280:Magnetics; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors