[Treating steroids dependent asthmatic patients with high dose beclomethasone dipropionate aerosol].
In order to provide a more effective alternative therapy for the steroid dependent asthmatic (SDA) patients, 23 SDA patients replaced their oral steroids with high dose beclomethasone dipropionate (1500 micrograms/d) inhalation were investigated. The changes of clinical features, pulmonary function and the Synacthen test were recorded. The results showed that about 82% of the patients replaced their oral steroids completely or partially with the inhalation therapy, the clinical features were improved in 13% of the patients and the failure rate was only 4.4%, the results also revealed that, after replacement, the pulmonary function of the patients were improved (P < 0.05); according to the results of Synacthen test, after alternative therapy for 3-6 months, the damaged reserve power and secretive ability of adrenal cortex of the patients were also partially improved (P < 0.01).
Dong
J
J
Huashan Hospital, Shanghai Medical University.
Shi
Z
Z
Cui
Y
Y
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011241:Prednisone; D019966:Substance-Related Disorders
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D001507:Beclomethasone; D011241:Prednisone; D006854:Hydrocortisone