Fever in uncomplicated Plasmodium falciparum malaria: randomized double-'blind' comparison of ibuprofen and paracetamol treatment.
Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-'blind' study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever > 38.5 degrees C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use.
Krishna
S
S
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pukrittayakamee
S
S
Supanaranond
W
W
ter Kuile
F
F
Ruprah
M
M
Sura
T
T
White
N J
NJ
D000082:Acetaminophen / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D000075202:Contraindications; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D007052:Ibuprofen