title: Carcinoma of the pancreatic head area. Therapy: nonoperative biliary drainage for palliation.
abstract: Jaundice is the dominant symptom in patients with biliary obstruction from carcinomas of the pancreatic head area. The many symptoms usually associated to prolonged biliary stasis (malnutrition, coagulopathy, pruritus hepatocellular failure, renal dysfunction, angiocolitis) is commonly resolved or relieved by biliary drainage. Palliation is frequently the only feasible treatment in these patients due to the biological aggressiveness of these tumors characterized by the early infiltration of adjacent tissues. Endoscopic and percutaneous procedures of biliary recanalization are as effective as those of surgical palliation, are more comfortable to the patients and burdened with a lower morbidity and mortality. In selected patients, palliation of jaundice can be combined with intraluminal radiotherapy or pancreatic drainage the latter aimed at the relief of the "obstructive" pain present in some patients with carcinoma of the area of the head of the pancreas.
authors.affiliation: Istituto di Clinica Chirurgica Generale, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Costamagna
authors.forename: A R
authors.initials: AR
authors.lastname: Cotroneo
authors.forename: M
authors.initials: M
authors.lastname: Mutignani
authors.forename: C
authors.initials: C
authors.lastname: Di Stasi
authors.forename: V
authors.initials: V
authors.lastname: Perri
mesh_terms: D003131:Combined Modality Therapy; D004322:Drainage; D006801:Humans; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000628:therapy*