title: Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.
abstract: New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
authors.affiliation: Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Gunma, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Kamishohara
authors.forename: A
authors.initials: A
authors.lastname: Odagawa
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Tsuruo
authors.forename: N
authors.initials: N
authors.lastname: Otake
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011684:Purine Nucleosides / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000903:Antibiotics, Antineoplastic; D011684:Purine Nucleosides; C015502:septacidin