title: Tracheoesophageal anastomosis, continent gastrostomy and oesophagostomy--a new experimental model in minipiglets.
abstract: Tracheoesophageal fistulae endanger newborn children by aspiration pneumonia. An animal model of this dangerous malformation was thought to be impossible until now. By tracheoesophageal anastomosis, occlusion of the oesophagogastral junction, proximal cervical oesophagostomy and continent gastrostomy in 25 minipiglets a reliable model of tracheoesophageal fistula has been developed. After establishing the model in a pilot study the mortality following the establishment of this procedure was 5.6% and the minipiglets survived in excellent condition for 2-10 week periods under complete alimentary restriction and gastrostomy feeding. Therefore the method seems to be suitable for long-term investigations on major oesophagotracheal surgery.
authors.affiliation: Clinic of Pediatric Surgery, University of Münster, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Schaarschmidt
authors.forename: K W
authors.initials: KW
authors.lastname: Paschertz
authors.forename: U
authors.initials: U
authors.lastname: Stratmann
authors.forename: L
authors.initials: L
authors.lastname: Ruprecht
authors.forename: G H
authors.initials: GH
authors.lastname: Willital
authors.forename: E
authors.initials: E
authors.lastname: Unsöld
mesh_terms: D000714:Anastomosis, Surgical / Q000662:veterinary; D000818:Animals; D000830:Animals, Laboratory / Q000601:surgery; D001835:Body Weight; D004032:Diet; D004195:Disease Models, Animal; D004750:Enteral Nutrition; D004933:Esophageal Atresia / Q000473:pathology; D004946:Esophagostomy / Q000662:veterinary; D004947:Esophagus / Q000601:surgery; D005774:Gastrostomy / Q000662:veterinary; D008297:Male; D013552:Swine; D013556:Swine, Miniature / Q000601:surgery; D014132:Trachea / Q000601:surgery; D014138:Tracheoesophageal Fistula / Q000601:surgery