Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.
Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca(2+)-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca(2+)-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.
Vito
P
P
T Cell Molecular Biology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lacanà
E
E
D'Adamio
L
L
D000470:Alkaloids / Q000494:pharmacology; D000544:Alzheimer Disease / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary; D003609:Dactinomycin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D053222:Fas Ligand Protein; D006825:Hybridomas; D007376:Interleukin-2 / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D053766:Presenilin-2; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction; D019311:Staurosporine; D013601:T-Lymphocytes; D014162:Transfection; D015854:Up-Regulation; D019014:fas Receptor / Q000378:metabolism
D000470:Alkaloids; D051017:Apoptosis Regulatory Proteins; D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D007376:Interleukin-2; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C490815:Pdcd6 protein, mouse; D053766:Presenilin-2; C095101:Psen2 protein, mouse; D011948:Receptors, Antigen, T-Cell; D019014:fas Receptor; D003609:Dactinomycin; D003907:Dexamethasone; D019311:Staurosporine; D002118:Calcium