Improvement of scleredema associated with IgA multiple myeloma after chemotherapy.
The presence of a monoclonal gammopathy in patients with chronic scleredema is a recently described, unusual association of unknown significance. There have been very occasional reports of multiple myeloma in such patients. We now report a patient with long-standing scleredema who developed an IgA-kappa multiple myeloma. Once chemotherapy for the myeloproliferative disorder was instituted, scleredema improved significantly, suggesting a pathogenetic link between the two conditions.
Pujol
J A
JA
Department of Dermatology, Hospital Clinico Universitario, Faculty of Medicine, Zaragoza, Spain.
Bueno
M
M
Fuertes
M A
MA
Gimenez
H
H
Carapeto
F J
FJ
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000473:pathology
D007070:Immunoglobulin A