Specific cleavage of synthetic renin substrate by mouse gamma-nerve growth factor.
Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity. Since other mouse kallikreins do not cleave this bond, gamma-NGF may play a regulatory role in the generation of antiogensin-II.
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Department of Anatomy and Cell Biology, Meharry Medical College, Nashville, Tennessee 37208, USA.
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D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007610:Kallikreins / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000737:chemistry / Q000378:metabolism*; D010446:Peptide Fragments / Q000302:isolation & purification / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D012083:Renin / Q000378:metabolism*; D017421:Sequence Analysis; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
D009414:Nerve Growth Factors; D010446:Peptide Fragments; D010455:Peptides; D000804:Angiotensin II; D007610:Kallikreins; D012697:Serine Endopeptidases; C079910:nerve growth factor, gamma; D012083:Renin