title: A randomized trial of amphotericin B alone or in combination with itraconazole in the treatment of mucocutaneous leishmaniasis.
abstract: A randomized trial of amphotericin B (AB) alone and in combination with oral itraconazole (IZ) is carried out in two groups of 10 mucocutaneous leishmaniasis patients from Bolivia and Peru. AB+IZ combination is no better than AB monotherapy, as far as efficacy and tolerability are concerned. No antagonism was detected.
authors.affiliation: Servicio de Dermatologia, Hospital de Clinicas Universitario, Miraflores, La Paz, Bolivia.
authors.forename: L V
authors.initials: LV
authors.lastname: Rodriguez
authors.forename: J P
authors.initials: JP
authors.lastname: Dedet
authors.forename: V
authors.initials: V
authors.lastname: Paredes
authors.forename: C
authors.initials: C
authors.lastname: Mendoza
authors.forename: F
authors.initials: F
authors.lastname: Cardenas
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D017964:Itraconazole; D000666:Amphotericin B