title: Activated protein C sensitivity ratio in pregnant women at delivery.
abstract: We studied activated protein C sensitivity ratio (APC-SR), factors V and VIII activity and von Willebrand antigen in control women, women using oral contraceptives, and pregnant women at delivery. The mean APC-SR of 2.4 in pregnant women was significantly lower than the mean APC-SR value of 3.5 for both the other groups and 45% of pregnant women had a ratio below the 5th percentile of the control group. None of them carried the R506-->Q mutation. This decreased ratio at delivery appeared to be connected, at least in part, with increased VIII activity. Thus, APC-SR at delivery should not be used to detect APC resistance.
authors.affiliation: Laboratoire de Biologie, CHI de Poissy, Université Paris V, INSERM CJF 94-02, Poissy, France.
authors.forename: F
authors.initials: F
authors.lastname: Mathonnet
authors.forename: P
authors.initials: P
authors.lastname: de Mazancourt
authors.forename: B
authors.initials: B
authors.lastname: Bastenaire
authors.forename: M
authors.initials: M
authors.lastname: Morot
authors.forename: N
authors.initials: N
authors.lastname: Benattar
authors.forename: S
authors.initials: S
authors.lastname: Beufé
authors.forename: J Y
authors.initials: JY
authors.lastname: Borg
authors.forename: Y
authors.initials: Y
authors.lastname: Giudicelli
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D003276:Contraceptives, Oral / Q000494:pharmacology*; D036861:Delivery, Obstetric; D005165:Factor V / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011486:Protein C / Q000502:physiology*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D003276:Contraceptives, Oral; D011486:Protein C; D014841:von Willebrand Factor; D005165:Factor V; D005169:Factor VIII