A fatal dothiepin overdose.
High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (Prothiaden) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature.
Cirimele
V
V
Institut de Médecine Légale, Strasbourg, France.
Kintz
P
P
Tracqui
A
A
Mangin
P
P
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000032:analysis* / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D004308:Dothiepin / Q000032:analysis* / Q000506:poisoning*; D017809:Fatal Outcome; D005554:Forensic Medicine / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry; D006801:Humans; D008297:Male; D011041:Poisoning / Q000097:blood / Q000175:diagnosis
D000929:Antidepressive Agents, Tricyclic; D004308:Dothiepin