[Eruptive nevus in the course of Lyell syndrome].
BACKGROUND
Eruptive nevus have been described after severe bullous cutaneous adverse drug reactions. We report herein a berloque-like nevus extension after toxic epidermal necrolysis.


METHODS
A 23 year-old woman was hospitalized for toxic epidermal necrolysis. A blister was in contact with a nevus. Four months after healing, extension of the nevus was seen on the blister area.


CONCLUSIONS
During toxic epidermal necrolysis and healing: 1) cytokines and growth factors are produced favouring nevocytes proliferation; 2) macromolecules are exposed on the wound bed; 3) adhesion molecules are expressed on nevocytes, restricting cell migration on exposed macromolecules. Interaction between matrix macromolecules and adhesion molecules could explain the limitation of nevus extension.
Jullien
D
D
Service de Dermatologie, Hôpital Henri-Mondor, Créteil.
Prévot
G
G
Wolkenstein
P
P
Roujeau
J C
JC
Revuz
J
J
D000328:Adult; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009508:Nevus, Pigmented / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications*
Extension en coulée d'un naevus après syndrome de Lyell.