The effect of low dose diclofenac sodium administered locally on heterotopic bone formation in rats.
The effect of a low dose of diclofenac sodium, administered locally, on heterotopic bone formation in rats was investigated. Heterotopic bone was induced by implantation of demineralised bone matrix into the gluteal muscles. Diclofenac was released continuously for 2 weeks from micro-osmotic pumps for each demineralised bone implant in the rats. Each had a control implant in the opposite gluteal muscle to which saline was released in the same way. The yield of new woven bone was determined after 4 weeks by measuring the ash-weights of the implants. Those of the diclofenac samples were significantly decreased compared to the controls. These results suggest that a low dose of diclofenac given locally decreases heterotopic bone formation in rats.
Risto
O
O
Department of Orthopaedics, University Hospital, Faculty of Health Sciences, Linköping University, Sweden.
Wahlström
O
O
Abdiu
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009999:Ossification, Heterotopic / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac