title: Genetic basis for resistance to polytropic murine leukemia viruses in the wild mouse species Mus castaneus.
abstract: Cultured cells derived from the wild mouse species Mus castaneus were found to be uniquely resistant to exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs). This MCF MuLV resistance is inherited as a genetically recessive trait in the progeny of F1 crosses between M. castaneus and MCF MuLV-susceptible laboratory mice. Examination of the progeny of backcrosses demonstrated that susceptibility is inherited as a single gene which maps to chromosome 1. The map location of this gene places it at or near the locus Rmc1, the gene encoding the receptor for MCF/xenotropic MuLVs, suggesting that resistance is mediated by the M. castaneus allele of this receptor.
authors.affiliation: Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Lyu
authors.forename: C A
authors.initials: CA
authors.lastname: Kozak
mesh_terms: D000818:Animals; D000835:Animals, Wild; D002460:Cell Line; D002478:Cells, Cultured; D002874:Chromosome Mapping; D005808:Genes, Recessive; D007113:Immunity, Innate / Q000235:genetics; D051379:Mice; D008806:Mice, Inbred AKR; D008811:Mice, Inbred DBA; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics / Q000502:physiology*; D009115:Muridae / Q000235:genetics* / Q000821:virology; D011991:Receptors, Virus / Q000235:genetics; D000089842:Xenotropic and Polytropic Retrovirus Receptor
chemical_list: D011991:Receptors, Virus; D000089842:Xenotropic and Polytropic Retrovirus Receptor; C000715268:Xpr1 protein, mouse