Hydrocephalus, mineralizing angiopathy, hypercholesterolemia, and hyperlipoprotein (a).
A boy born at 34 weeks gestation with initially normal development presented with acute hydrocephalus at 22 months. Subsequently his development has been slow and complicated clinically by epilepsy. Upon extensive investigation, he has been found to have extremely elevated lipoprotein(a) levels, hypercholesterolemia (familial), and lesions of the cortex and meninges. Radiologic studies have disclosed a mineralizing angiopathy.
Manzur
A Y
AY
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Poskitt
K J
KJ
Norman
M G
MG
Frohlich
J
J
Crichton
J U
JU
D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005355:Fibrosis; D006801:Humans; D006849:Hydrocephalus / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006938:Hyperlipoproteinemia Type II / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D007223:Infant; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D011859:Radiography
D002556:Cerebrospinal Fluid Proteins; D008078:Cholesterol, LDL; D017270:Lipoprotein(a)