Azo polymeric hydrogels for colon targeted drug delivery.
Azo polymeric hydrogels were developed for colon specific targeting. Methacryloyloxy azobenzene was synthesized and hydrogels were prepared by copolymerizing with hydroxyethyl methacrylate. These hydrogels were characterized by various spectral techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy. Equilibrium swelling measurements of the hydrogels were carried out in distilled water and also in simulated gastric and intestinal fluids. The in vitro release studies of the incorporated 5-flurouracil were carried out in simulated gastric and intestinal fluids. The in vitro release profiles of the drug were also obtained in the presence of azoreductase in the culture of intestinal flora. The release was faster and almost followed a zero order pattern. This can be attributed to the cleavage of the azo crosslinks in the hydrogel by the azoreductase and the release of the entrapped drug at the site of targeting i.e., colon.
Shantha
K L
KL
Biomaterials Division, Central Leather Research Institute, Adyar, Madras, India.
Ravichandran
P
P
Rao
K P
KP
D001391:Azo Compounds / Q000737:chemistry*; D001421:Bacteria, Anaerobic / Q000378:metabolism; D001672:Biocompatible Materials / Q000592:standards; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D016503:Drug Delivery Systems; D005243:Feces / Q000737:chemistry; D005472:Fluorouracil / Q000378:metabolism; D005782:Gels / Q000592:standards; D006801:Humans; D066298:In Vitro Techniques; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D001391:Azo Compounds; D001672:Biocompatible Materials; D005782:Gels; D008689:Methacrylates; D011108:Polymers; C005044:hydroxyethyl methacrylate; C009850:azobenzene; D005472:Fluorouracil