title: Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717.
abstract: A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2,5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC50 being 1.9 x 10(-4) M.
authors.affiliation: Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd., Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kagamizono
authors.forename: E
authors.initials: E
authors.lastname: Nishino
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: A
authors.initials: A
authors.lastname: Kawashima
authors.forename: M
authors.initials: M
authors.lastname: Kishimoto
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: B M
authors.initials: BM
authors.lastname: He
authors.forename: Z X
authors.initials: ZX
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D003904:Mitosporic Fungi / Q000378:metabolism* / Q000648:ultrastructure; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D009025:Morpholines; D010975:Platelet Aggregation Inhibitors; C085610:lateritin