Stevens-Johnson syndrome resulting from whole-brain radiation and phenytoin.
Phenytoin, one of the most widely prescribed anticonvulsants, and steroids are routinely utilized for seizure prophylaxis in patients with various intracranial tumors. We report a case of severe Stevens-Johnson syndrome (SJS), documented by biopsy, which occurred in a patient, with metastatic squamous cell carcinoma receiving phenytoin, whole-brain radiation therapy (WBRT), and a tapering steroid dose. The pathogenesis and implications are then briefly discussed.
Cockey
G H
GH
College of Medicine, University of Florida, Gainesville, USA.
Amann
S T
ST
Reents
S B
SB
Lynch
J W
JW
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000556:secondary; D018890:Chemoprevention; D016371:Cranial Irradiation / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D013125:Spinal Neoplasms / Q000532:radiotherapy / Q000556:secondary; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology
D000927:Anticonvulsants; D005938:Glucocorticoids; D010672:Phenytoin; D003907:Dexamethasone