Anti-infection treatment of a transcutaneous device by a collagen-rifampicine composite.
The polyurethane surface of a transcutaneous energy transmitter, which is implanted into a subcutaneous pouch for a total artificial heart, was coated with a Type I atelocollagen and rifampicine composite to prevent the infection that frequently occurs in the interfacial space between the tissue and the device. The specimen obtained after 7 weeks from a transcutaneous energy transmitter placed in a dorsal subcutaneous pouch of a dog revealed noninfected but well-attached dermal tissue without specific epithelial down-growth around the transcutaneous energy transmitter surface at the pouch-orifice area. The transcutaneous energy transmitter implanted in the pouch adhered well to the subcutaneous tissues. The collagen matrix seemed to have provided a favorable environment for the regenerating dermal tissue to obstruct the interfacial space. The coated collagen-antibiotic composite was degraded.
Suh
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Institute of Biomedical Engineering, College of Medicine, Seoul National University, Korea.
Suh
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Min
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003094:Collagen / Q000302:isolation & purification; D004285:Dogs; D005069:Evaluation Studies as Topic; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D019736:Prostheses and Implants / Q000009:adverse effects*; D012293:Rifampin / Q000008:administration & dosage*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D011140:Polyurethanes; D003094:Collagen; D012293:Rifampin