title: Neuronal ceroid-lipofuscinosis in a cat.
abstract: Neuronal ceroid-lipofuscinosis was diagnosed in a young adult domestic short-haired cat euthanatized because of severe progressive neurologic disease. Clinical signs included blindness, seizures, and decreased mentation. An autofluorescent pigment, identified as ceroid-lipofuscin by electron microscopy and staining properties, was found within neurons of the central and peripheral nervous systems. A diffuse reactive astrocytosis accompanied by multifocal microgliosis was visible in all areas of the brain. Retinal atrophy with intraneuronal lipopigment accumulation was also identified. Contrary to the human neuronal ceroid-lipofuscinoses, pigment deposition appeared to be restricted to neural tissues.
authors.affiliation: Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Bildfell
authors.forename: C
authors.initials: C
authors.lastname: Matwichuk
authors.forename: S
authors.initials: S
authors.lastname: Mitchell
authors.forename: P
authors.initials: P
authors.lastname: Ward
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000473:pathology; D001766:Blindness / Q000209:etiology / Q000662:veterinary; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology; D002415:Cats; D002490:Central Nervous System / Q000473:pathology; D008062:Lipofuscin / Q000032:analysis*; D008297:Male; D017628:Microglia / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron / Q000662:veterinary; D009472:Neuronal Ceroid-Lipofuscinoses / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009474:Neurons / Q000737:chemistry* / Q000648:ultrastructure; D017933:Peripheral Nervous System / Q000473:pathology; D012160:Retina / Q000473:pathology / Q000648:ultrastructure; D012640:Seizures / Q000209:etiology / Q000662:veterinary; D013194:Staining and Labeling; D013787:Thalamic Nuclei / Q000473:pathology / Q000648:ultrastructure
chemical_list: D008062:Lipofuscin