title: Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone.
abstract: OBJECTIVE
  To evaluate the ability of an ultrasound (US)-measured periovulatory endometrial thickness to predict conception in hMG-stimulated cycles.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  A university-based tertiary practice.
  
  
  METHODS
  One hundred twelve patients undergoing 292 cycles of ovulation induction with hMG alone.
  
  
  METHODS
  A periovulatory transvaginal US measurement of endometrial thickness was obtained during cycles of ovulation induction with hMG alone. Clinical pregnancy was defined by fetal cardiac activity. Sensitivity and false-positive rates for multiple discriminatory values of endometrial thickness were calculated and a relative operating characteristic (ROC) curve was constructed to evaluate the performance of this test as a predictor of pregnancy.
  
  
  RESULTS
  Thirty-eight of 292 cycles resulted in pregnancy. Conception and nonconception cycles showed similar demographics, diagnoses, peak E2, maximum number of follicles, midluteal P, and mean endometrial thickness. Ovulatory dysfunction was a more frequent diagnosis in the conception group. Relative operating characteristic analysis for endometrial thickness as a predictor of pregnancy yielded an area under the curve of 0.623 +/- 0.049 (mean +/- SD).
  
  
  CONCLUSIONS
  Endometrial thickness is a valid screening test for conception outcome in cycles stimulated with hMG. A periovulatory endometrial thickness > or = 10 mm defined 91% of conception cycles. No pregnancy occurred when the endometrium measured < 7 mm.
authors.affiliation: Washington University School of Medicine, Department of Obstetrics and Gynecology, St. Louis, Missouri, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Isaacs
authors.forename: C S
authors.initials: CS
authors.lastname: Wells
authors.forename: D B
authors.initials: DB
authors.lastname: Williams
authors.forename: R R
authors.initials: RR
authors.lastname: Odem
authors.forename: M J
authors.initials: MJ
authors.lastname: Gast
authors.forename: R C
authors.initials: RC
authors.lastname: Strickler
mesh_terms: D000328:Adult; D004717:Endometrium / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D008991:Monitoring, Physiologic; D010062:Ovulation Induction / Q000379:methods*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D005300:Fertility Agents, Female; D008596:Menotropins