title: [Stevens-Johnson syndrome after lamotrigine treatment].
abstract: We report a 18 years old female with Lennox-Gastaut syndrome under treatment with sodium valproate, carbamazepine and clonazepam. When seizures increased we stopped carbamazepine and introduced lamotrigine slowly. One month later the girl developed haemorrhagic erosions in mucoses and limbs with deterioration of her general state. Skin biopsy confirmed the diagnosis of erythema multiforme, the Stevens-Johnson's form. The immediate withdrawal of lamotrigine and treatment with antihystaminics and steroids was followed of a slowly favourable course with disappearance of symptomatology one month later. It's another case of Stevens-Johnson syndrome related to the introduction of lamotrigine in polytherapy.
authors.affiliation: Consorci Sant Gregori, Girona.
authors.forename: J
authors.initials: J
authors.lastname: Campistol
authors.forename: M
authors.initials: M
authors.lastname: Geli
authors.forename: E
authors.initials: E
authors.lastname: Llistosella
authors.forename: J
authors.initials: J
authors.lastname: Molins
authors.forename: M
authors.initials: M
authors.lastname: Llobet
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000008:administration & dosage / Q000627:therapeutic use; D002998:Clonazepam / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004817:Epidermis / Q000473:pathology / Q000648:ultrastructure; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D009336:Necrosis / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D002220:Carbamazepine; D002998:Clonazepam; D014635:Valproic Acid; D000077213:Lamotrigine
vernacular_title: Sídrome de Stevens-Johnson tras la introducción de lamotrigina.