[Determination of procollagen III levels in serum and broncho-alveolar lavage fluid in patients with interstitial lung disease and its clinical significance].
Serum and broncho-alveolar lavage fluid (BALF) levels of procollagen III (PCIII) were determined in 26 patients with interstitial lung disease (ILD) and healthy subjects as controls. The results showed: (1) Levels of PCIII in serum and BALF were significantly higher in the patient group than those in the control group; (2) A highly positive correlation was found between PCIII levels and alveolar macrophage counts in BALF in the patient group. (3) PCIII level in BALF (albumin as a denominator) is higher than that in own serum both in control and patient group, the higher level of PCIII in BALF might be the result of local production. We are of the opinion that changes of PCIII level in serum and BALF might be helpful in the evaluation of the turnover of collagen in the lung.
Chen
B
B
Respiratory Disease Research Institute China Medical University, Shenyang.
Zhao
H
H
Lu
C
C
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011347:Procollagen / Q000378:metabolism*; D011658:Pulmonary Fibrosis / Q000378:metabolism*
D011347:Procollagen