The use of trabeculectomy to study the pharmacological modulation of ophthalmic wound healing.
A trabeculectomy model was developed to test the efficacy of a putative interleukin-1 blocker on the modulation of ophthalmic wound healing in the pigmented rabbit. The corticosteroid, methylprednisolone acetate, was used as a positive control and was effective in prolonging the time to failure of the trabeculectomy. The experimental compound CK-103A was found to be more efficacious than methyl prednisolone acetate. CK-103A increased the time of failure by 79%, with no side effects at the doses tested to date.
Schwade
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ND
Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.
Chiou
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GC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D009877:Endophthalmitis / Q000503:physiopathology; D007267:Injections; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D007429:Intraocular Pressure / Q000502:physiology; D008775:Methylprednisolone / Q000494:pharmacology; D008954:Models, Biological; D011724:Pyridazines / Q000494:pharmacology*; D011817:Rabbits; D012590:Sclera / Q000601:surgery; D013047:Specific Pathogen-Free Organisms; D013524:Surgical Flaps; D014130:Trabeculectomy; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; C091706:CK 103A; D007375:Interleukin-1; D011724:Pyridazines; D008775:Methylprednisolone