Non-ketotic hyperosmolar coma complicating steroid treatment in childhood nephrosis.
Two nephrotic children treated with prednisone developed steroid-induced diabetes and non-ketotic hyperosmolar coma (NKHC). Both patients presented with convulsions, coma and shock. The glucose concentration of the cerebrospinal fluid was 425 mg/dl and 622 mg/dl, respectively. Both patients had no diabetic family history, but had been treated with prednisone for 4 and 8 months, receiving total doses of 6.6 and 10.8 g, respectively. Despite conventional therapy, both patients deteriorated rapidly and died several hours later. Steroid-induced diabetes associated with NKHC is a rare but serious complication of steroid therapy.
Yang
J Y
JY
Paediatric Department, First Teaching Hospital of Beijing Medical University, China.
Cui
X L
XL
He
X J
XJ
D000293:Adolescent; D002648:Child; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000139:chemically induced*; D008297:Male; D009401:Nephrosis / Q000188:drug therapy*; D011241:Prednisone / Q000009:adverse effects*
D005938:Glucocorticoids; D011241:Prednisone