On the nature of the link between malignant hyperthermia and exertional heatstroke.
Malignant hyperthermia (MH) is a rare myopathy inducing severe accident when carriers are exposed to triggering agents. MH susceptibility (MHS) is assessed by pharmacological tests performed on muscle strips. Exertional heat stroke (EHS) is a severe accident occurring during long and strenuous exercise. It has been observed that numerous EHS patients are susceptible to MH according to pharmacological tests. Because most of those EHS-MHS subjects were soldiers, we hypothesize that military duty could select subjects with infraclinical myopathy and therefore would increase the MHS:EHS subject ratio.
Bourdon
L
L
Centre de Recherces du Service de Santé des Armées, La Tronche, France.
Canini
F
F
D000818:Animals; D001833:Body Temperature Regulation; D002110:Caffeine / Q000494:pharmacology; D015220:Calcium Channels / Q000172:deficiency / Q000235:genetics; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000175:diagnosis; D004734:Energy Metabolism; D005602:France / Q000453:epidemiology; D006221:Halothane / Q000494:pharmacology; D018883:Heat Stroke / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008305:Malignant Hyperthermia / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D008889:Military Personnel; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D009124:Muscle Proteins / Q000172:deficiency / Q000235:genetics; D018482:Muscle, Skeletal / Q000378:metabolism; D005082:Physical Exertion; D019837:Ryanodine Receptor Calcium Release Channel; D013552:Swine
D015220:Calcium Channels; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel; D002110:Caffeine; D006221:Halothane