HLA phenotypes and severe Rh(D) immunization.
Blood samples from 24 Rh(D) immunized women were analyzed for antibody titers and quantification of anti-D. The HLA-DR and -DQ polymorphisms were identified as RFLP. In 11 women with titers 16-256 the HLA-DQB1 allele *0201 was found in 18%, i e as in a reference population. In 13 women with titers > or = 512 the HLA-DQB1 allele *0201 was found in 85% indicating a correlation between severe Rh(D) immunization with high titers/quantification values and the DQB1 allele *0201. In this group the fetus was severely affected by the immunization and treatment during pregnancy was frequently needed. HLA phenotyping of women known to have anti-D antibodies early in pregnancy seems to be an effective way to assess the probability of severe hemolytic disease of the newborn.
Hildén
J O
JO
Department of Transfusion Medicine & Clinical Immunology, University Hospital, Linköping, Sweden.
Gottvall
T
T
Lindblom
B
B
D000483:Alleles; D005260:Female; D005315:Fetal Diseases / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000276:immunology*; D018029:Rho(D) Immune Globulin / Q000097:blood / Q000276:immunology
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D018029:Rho(D) Immune Globulin