New protein functions in yeast chromosome VIII.
The analysis of the 269 open reading frames of yeast chromosome VIII by computational methods has yielded 24 new significant sequence similarities to proteins of known function. The resulting predicted functions include three particularly interesting cases of translation-associated proteins: peptidyl-tRNA hydrolase, a ribosome recycling factor homologue, and a protein similar to cytochrome b translational activator CBS2. The methodological limits of the meaningful transfer of functional information between distant homologues are discussed.
Ouzounis
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European Molecular Biology Laboratory-Heidelberg, Germany.
Bork
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P
Casari
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Sander
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C
D000429:Alcohol Oxidoreductases; D000595:Amino Acid Sequence; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D015825:Chromosomes, Fungal; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D017385:Sequence Homology
D005656:Fungal Proteins; D024101:Mitochondrial Proteins; C114727:RRF1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000429:Alcohol Oxidoreductases; C097954:PAN5 protein, S cerevisiae; D002265:Carboxylic Ester Hydrolases; C019674:aminoacyl-tRNA hydrolase