Bullous drug eruption to griseofulvin in a man with Hailey-Hailey disease.
Hailey-Hailey disease (chronic benign familial pemphigus) is a blistering disease characterized by episodic maceration and erosions in areas subject to friction and trauma such as the neck, axilla, and other intertriginous areas. We report a case in which a griseofulvin-induced drug eruption led to a generalized vesiculobullous eruption requiring treatment in a burn treatment center. This emphasizes that Hailey-Hailey disease, usually confined to relatively small areas, has the potential to cause blistering throughout the epidermis under certain conditions.
Meffert
J J
JJ
Department of Dermatology, Wilford Hall Medical Center, Lackland AFB, Texas, USA.
Davis
B M
BM
Campbell
J C
JC
D000279:Administration, Cutaneous; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D006118:Griseofulvin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000188:drug therapy*; D012835:Silver Nitrate / Q000008:administration & dosage / Q000627:therapeutic use; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000188:drug therapy
D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D006118:Griseofulvin; D012835:Silver Nitrate