Polymorphonuclear leukocytes (PMN) activity in peripheral blood in patients with esophageal carcinoma.
The aim of this study was to evaluate some of the PMN functions connected with phagocytosis in 34 patients with esophageal carcinoma, confronted with a clinical progression of the neoplastic disease, according to TNM classification. The level of the neoplastic markers--SCC and CEA antigens were determined also. In the examined group of patients significant decrease in the mean values of FcR and CR receptors expression, migration, chemotaxis and phagocytosis of PMN were observed. No correlation was found between the percentage cells with FcR and CR and phagocytosis and clinical progression of neoplasma. Significant differences were in mean values of chemotaxis and migration in group with IV stage TNM. There was no found correlation between granulocytic tests and levels of SCC and CEA.
Jabłońska
E
E
Department of Immunopathology, Medical Academy, Bialłystok, Poland.
Pietruska
Z
Z
Furman
M
M
Kozłowski
M
M
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D002634:Chemotaxis, Leukocyte; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis
D000936:Antigen-Antibody Complex; D014408:Biomarkers, Tumor