Codon repeats in genes associated with human diseases: fewer repeats in the genes of nonhuman primates and nucleotide substitutions concentrated at the sites of reiteration.
Five human diseases are due to an excessive number of CAG repeats in the coding regions of five different genes. We have analyzed the repeat regions in four of these genes from nonhuman primates, which are not known to suffer from the diseases. These primates have CAG repeats at the same sites as in human alleles, and there is similar polymorphism of repeat number, but this number is smaller than in the human genes. In some of the genes, the segment of poly(CAG) has expanded in nonhuman primates, but the process has advanced further in the human lineage than in other primate lineages, thereby predisposing to diseases of CAG reiteration. Adjacent to stretches of homogeneous present-day codon repeats, previously existing codons of the same kind have undergone nucleotide substitutions with high frequency. Where these lead to amino acid substitutions, the effect will be to reduce the length of the original homopolymeric stretch in the protein.
Djian
P
P
Centre National de la Recherche Scientifique, Centre de Recherche sur l'Endocrinologie, Moléculaire et le Développement, Meudon, France.
Hancock
J M
JM
Chana
H S
HS
D000818:Animals; D001483:Base Sequence; D003062:Codon; D016384:Consensus Sequence; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005971:Glutamates / Q000235:genetics; D000882:Haplorhini / Q000235:genetics*; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D017827:Machado-Joseph Disease / Q000235:genetics; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D012326:RNA Splicing; D011944:Receptors, Androgen / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013132:Spinocerebellar Degenerations / Q000235:genetics
D003062:Codon; D005971:Glutamates; D011944:Receptors, Androgen