title: How fission yeast fission in the middle.
abstract: In fission yeast, we propose that the division plane may be positioned by the position of the premitotic nucleus, perhaps by a signal emanating from the nucleus. Gene products involved in the assembly of the ring and its temporal and spatial controls are beginning to be characterized. Some of these, such as mid1p, may be involved in signals that position the division site. In animal cells, the division site may be determined by analogous signals emanating from the mitotic asters (Rappaport, 1986). We speculate that the signals defined in fission yeast will help identify signals that determine the division plane in all kinds of eukaryotes.
authors.affiliation: Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.
authors.forename: F
authors.initials: F
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: Nurse
mesh_terms: D002455:Cell Division / Q000502:physiology*; D005656:Fungal Proteins / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics
chemical_list: D005656:Fungal Proteins; C090463:MID1 protein, S cerevisiae; D008562:Membrane Glycoproteins; D029701:Saccharomyces cerevisiae Proteins