A biochemical study on combined treatment of experimental silicosis with tetradrine-PVNO and tetradrine-QOHP in rats.
A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats.
Yu
L
L
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China.
Zhou
C Q
CQ
Li
Y R
YR
Qu
L
L
Xing
K J
KJ
Du
Q C
QC
D000470:Alkaloids / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D044182:Benzylisoquinolines; D004150:Dipeptidases / Q000097:blood; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D010958:Plasminogen / Q000378:metabolism; D011144:Polyvinylpyridine N-Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012829:Silicosis / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism
D000470:Alkaloids; D044182:Benzylisoquinolines; D010879:Piperazines; C009438:tetrandrine; D010958:Plasminogen; D011144:Polyvinylpyridine N-Oxide; D008995:Monoamine Oxidase; D004150:Dipeptidases; C022449:proline dipeptidase