title: Recombinant human DNase in management of lobar atelectasis due to retained secretions.
abstract: Recombinant human deoxyribonuclease (rhDNase) is an agent which reduces the viscoelasticity of purulent sputum. Two cases are reported in which rhDNase was utilised for the management of lobar atelectasis due to retained purulent secretions.
authors.affiliation: Section of Pulmonary and Critical Care Medicine, Norwalk Hospital, Connecticut 06856, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Touleimat
authors.forename: C S
authors.initials: CS
authors.lastname: Conoscenti
authors.forename: J M
authors.initials: JM
authors.lastname: Fine
mesh_terms: D000328:Adult; D003850:Deoxyribonuclease I / Q000627:therapeutic use*; D005100:Expectorants / Q000627:therapeutic use*; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000188:drug therapy*; D013183:Sputum / Q000187:drug effects
chemical_list: D005100:Expectorants; D011994:Recombinant Proteins; C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I