title: [Changes in the natural history of peptic ulcer after Helicobacter pylori eradication. Randomized, double-blind, placebo controlled trial. Follow-up of 44 months].
abstract: We included 63 patients (p) with duodenal ulcer and Helicobacter pylori infection to be treated with Famotidine 40mg/day for six weeks. In the first ten days one group of 33p (TG) received Metronidazole 250mg plus Amoxicillin 500mg T.I.D and 30p (PG) placebo. Helicobacter pylori was eradicated in 62.5% of TG. Infection was always associated with ulcer recurrence. Healing was similar in both groups but recurrence was statistically significant after three month in PG and in the first year all Pg had relapsed. At 44 month only 25% of TG relapsed. The natural history of peptic ulcer disease was changed with Helicobacter pylori eradication.
authors.affiliation: Servicio de Gastroenterología, Hospital Vargas de Caracas.
authors.forename: R
authors.initials: R
authors.lastname: Piñero
authors.forename: J
authors.initials: J
authors.lastname: Ramon Poleo
authors.forename: M
authors.initials: M
authors.lastname: Urrestarazo
authors.forename: N
authors.initials: N
authors.lastname: Serrano
authors.forename: R
authors.initials: R
authors.lastname: Olavarría
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology*; D015738:Famotidine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D012008:Recurrence; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents; D010406:Penicillins; D008795:Metronidazole; D015738:Famotidine; D000658:Amoxicillin
vernacular_title: Cambio de la historia natural de la ulcera duodenal después de la erradicacíon de Helicobacter pyroli. Estudio aleatório, doble ciego, controlado con placebo. Seguimiento de 44 meses.