title: Active epilepsy in mentally retarded children. II. Etiology and reduced pre- and perinatal optimality.
abstract: A population-based study of active epilepsy in mentally retarded children identified 98 children, 6-13 years old. A biopathological origin was established in 66% of mildly and 92% of severely retarded children: a prenatal etiology was considered in 51% and 57%, a perinatal in 9% and 19%, a postnatal in 6% and 16% and an untraceable etiology in 34% and 8%, respectively. Severe mental retardation was more frequent in the peri- and postnatal groups (80% and 83%) than in the prenatal and untraceable groups (67% and 29%). Thirty-four pre- and perinatal optimal items were defined. Children with a prenatal etiology did not differ from controls in any of the periods. Children with a perinatal etiology had, compared with controls, higher proportions of non-optimal items successively increasing through the pre- and perinatal periods showing the accumulation of negative events.
authors.affiliation: Department of Pediatrics, University of Göteborg, Ostra Hospital, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Steffenburg
authors.forename: G
authors.initials: G
authors.lastname: Hagberg
authors.forename: M
authors.initials: M
authors.lastname: Kyllerman
mesh_terms: D000293:Adolescent; D001724:Birth Weight; D001921:Brain / Q000002:abnormalities; D001927:Brain Diseases / Q000150:complications; D016009:Chi-Square Distribution; D002648:Child; D015331:Cohort Studies; D004827:Epilepsy / Q000209:etiology* / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000150:complications* / Q000235:genetics; D008297:Male; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors