title: Evaluation of a hypertonic sodium chloride/dextran solution for treatment of traumatic shock in dogs.
abstract: OBJECTIVE
  To compare the efficacy of 7% NaCl solution (hypertonic saline) in 6% dextran 70 solution (HSD) with that of lactated Ringer's solution (LRS) for treatment of dogs in traumatic shock.
  
  
  METHODS
  Prospective, randomized, clinical study.
  
  
  METHODS
  16 traumatized adult dogs with clinical signs of shock.
  
  
  METHODS
  Physical, hemodynamic, blood gas, and clinical chemistry measurements were performed prior to treatment. Initial treatment consisted of HSD (n = 8) or LRS (n = 8) administered as a bolus (5 ml/kg of body weight, IV) over a 3-minute period, followed by administration of additional LRS and other treatments to restore hemodynamic and physical criteria to within reference limits. Measurements were repeated for 3 hours after initial treatment. The volumes of LRS and HSD administered were recorded hourly. Degree of injury was scored by using a trauma severity index.
  
  
  RESULTS
  Dogs responded similarly to the treatments, and all but 3 dogs survived to be discharged. The amount of fluid administered to dogs in the HSD group over the final 2 hours of the study was significantly less than that administered to the dogs in the LRS group. Serum sodium concentration and osmolality of the dogs in the HSD group were not significantly greater than those values in the LRS group. Bradyarrhythmias were observed in 2 dogs in the HSD group.
  
  
  CONCLUSIONS
  Hypertonic sodium chloride/dextran solution is safe and effective for resuscitating dogs in traumatic shock. Seven percent NaCl in 6% dextran 70 may reduce the need for isotonic fluids in the hours after initial resuscitation.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, College of Medicine, Ohio State University, Columbus 43210, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Schertel
authors.forename: D A
authors.initials: DA
authors.lastname: Allen
authors.forename: W W
authors.initials: WW
authors.lastname: Muir
authors.forename: B D
authors.initials: BD
authors.lastname: Hansen
mesh_terms: D000063:Accidents, Traffic; D000818:Animals; D003911:Dextrans / Q000627:therapeutic use*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs / Q000293:injuries*; D005440:Fluid Therapy / Q000662:veterinary*; D007552:Isotonic Solutions / Q000627:therapeutic use; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011446:Prospective Studies; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012774:Shock, Traumatic / Q000628:therapy / Q000662:veterinary*; D015599:Trauma Severity Indices; D016896:Treatment Outcome
chemical_list: D003911:Dextrans; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic