Comparative entry of carboplatin and sucrose in endolymph in the rat cochlea.
The permeability of the perilymphatic-endolymphatic interface for carboplatin was determined after lateral cerebral ventricle infusion of radioactive carboplatin (cis-diamine[1,1-cyclobutane-1-14C-dicarboxylate]platinum) to rats. [14C]sucrose, a similar weight molecule was used for comparison of the kinetics in the inner ear fluids. 14C-radioactivity was measured in perilymph and endolymph. The rate of elimination of the tracers from perilymph was equivalent indicating no difference in transport across the blood-perilymph barrier. The transport from perilymph to endolymph was very restricted for both substances. The present study indicates that the ototoxic effect of carboplatin cannot be explained by a specific endolymphatic transport mechanism.
Laurell
G
G
Institut National de la Santé et de la Recherche Médicale U 251, Department of Physiology, Faculté Xavier Bichat, Université Paris, France.
Teixeira
M
M
Sterkers
O
O
Ferrary
E
E
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001826:Body Fluids / Q000378:metabolism; D002250:Carbon Radioisotopes; D016190:Carboplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004710:Endolymph / Q000378:metabolism*; D007276:Injections, Intraventricular; D010498:Perilymph / Q000378:metabolism; D051381:Rats; D013395:Sucrose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000378:metabolism
D000970:Antineoplastic Agents; D002250:Carbon Radioisotopes; D013395:Sucrose; D016190:Carboplatin