Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.
We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.
Handelsman
L
L
Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA.
Limpitlaw
L
L
Williams
D
D
Schmeidler
J
J
Paris
P
P
Stimmel
B
B
D000328:Adult; D000547:Amantadine / Q000008:administration & dosage* / Q000009:adverse effects; D003042:Cocaine / Q000009:adverse effects; D018491:Dopamine Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006556:Heroin Dependence / Q000523:psychology / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000523:psychology / Q000534:rehabilitation*; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
D018491:Dopamine Agonists; D000547:Amantadine; D003042:Cocaine; D008691:Methadone