title: Metabotropic glutamate receptors are involved in TEA-induced long-term potentiation in area CA1 of the hippocampus.
abstract: A brief application of the K+ channel blocker tetraethylammonium induces a long-lasting potentiation in the CA1 region of hippocampal slices (TEA LTP). We report here that metabotropic glutamate receptors (mGluRs) contribute to this kind of synaptic enhancement, since the mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine ((+) MCPG) inhibits TEA LTP with a concentration-dependent component.
authors.affiliation: Federal Institute for Neurobiology, Deparatment of Neurophysiology, Magdeburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Platt
authors.forename: T
authors.initials: T
authors.lastname: Behnisch
authors.forename: K G
authors.initials: KG
authors.lastname: Reymann
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*
chemical_list: D018094:Receptors, Metabotropic Glutamate; D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium