Tumor cells cultured in vivo in diffusion chambers induce hematological alterations.
We have studied in BALB/c mice the hematological alterations of the host induced by the growth of tumor cells in diffusion chambers (DC) In this model, host-tumor interactions are only mediated by soluble factors. Tumor cells proliferate and grow in DC up to 15 days after implant. Our results show a reversal of the granulocyte-lymphocyte ratio in peripheral blood, with lymphopenia and a relative increase of myeloid progenitors in the bone marrow of mice bearing DC with M3 tumor cells (M3TC).
Diament
M
M
Departamento de Investigaciones, Instituto de Oncologia A.H.Roffo Universidad de Buenos Aires, Argentina.
Klein
S
S
Rodriguez Paradisi
E
E
Elia
I D
ID
De Bonaparte
Y P
YP
D000236:Adenoma; D000818:Animals; D001854:Bone Marrow Cells; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D015194:Diffusion Chambers, Culture; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D007958:Leukocyte Count; D008297:Male; D015674:Mammary Neoplasms, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured / Q000166:cytology