Increased cerebral blood flow during m-CPP exacerbation of obsessive-compulsive disorder.
The partial serotonin agonist m-chlorophenyl-piperazine (m-CPP) has been reported to increase obsessive-compulsive symptoms in some patients with obsessive-compulsive disorder (OCD). The authors investigated the underlying physiological mechanisms of this variable exacerbation by imaging regional cerebral blood flow with the planar xenon-133 method after administration of oral m-CPP (0.5 mg/kg). Seven patients who responded to m-CPP with symptomatic exacerbation had a marked increase in global cortical perfusion (18.1%), in contrast to the remaining 7 nonresponders to m-CPP, who showed no change. These results suggest that m-CPP exacerbation of OCD symptoms is associated with increased cortical blood flow.
Hollander
E
E
Department of Brain Imaging, New York State Psychiatric Institute, USA.
Prohovnik
I
I
Stein
D J
DJ
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000098:blood supply*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D010879:Piperazines; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D017366:Serotonin Receptor Agonists; D014980:Xenon Radioisotopes
D010879:Piperazines; D017366:Serotonin Receptor Agonists; D014980:Xenon Radioisotopes; C015068:1-(3-chlorophenyl)piperazine