CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.
Members of the Tumour Necrosis Factor-Receptor (TNFR) family play an essential role in the control of lymphoid cell growth and differentiation. The ligand of one of its lymphoid-specific members, CD27, was recently characterized as CD70, a type II transmembrane molecule with homology to TNF that is expressed on activated T and B cells. Ligation of CD27 by its natural ligand generates a potent costimulatory signal for cytokine production and proliferation of activated T cells. In contrast to normal B cells, where CD27 expression is confined to germinal centre cells and to a small subset of circulating B lymphocytes, CD27 expression is found on a large array of distinct B-cell neoplasia. Here, we review recent data on the expression and function of TNFR family members on normal and malignant lymphocytes and propose a role for CD27-CD70 interaction in B-cell development.
Lens
S M
SM
Department of Clinical (Viro-)Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
de Jong
R
R
Hintzen
R Q
RQ
Koopman
G
G
van Lier
R A
RA
van Oers
R H
RH
D015703:Antigens, CD; D001402:B-Lymphocytes / Q000166:cytology* / Q000473:pathology; D053282:CD27 Ligand; D002455:Cell Division / Q000502:physiology; D006801:Humans; D015448:Leukemia, B-Cell / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008565:Membrane Proteins / Q000502:physiology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000502:physiology*
D015703:Antigens, CD; D053282:CD27 Ligand; C505771:CD70 protein, human; D008565:Membrane Proteins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7