Use of micellar electrokinetic capillary chromatography in the study of in vitro metabolism of phenol by human liver microsomes.
Micellar electrokinetic capillary chromatography (MECC) is used for analysis of microsome incubation samples. Phenol, a neutral analyte, is separated from interferences. The separation is achieved without sample clean-up. MECC is shown to be advantageous for situations where rapid sampling with minimum handling is desired.
Davies
M I
MI
Department of Chemistry, University of Kansas, Lawrence 66045, USA.
Lunte
C E
CE
Smyth
M R
MR
D002138:Calibration; D002845:Chromatography / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006873:Hydroquinones / Q000032:analysis; D008823:Micelles; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D019800:Phenol; D010636:Phenols / Q000378:metabolism*; D012015:Reference Standards
D006873:Hydroquinones; D008823:Micelles; D010636:Phenols; D019800:Phenol; C031927:hydroquinone