[Cytogenetic abnormalities in seven patients with the Sezary syndrome].
The cytogenetic studies performed on 7 patients diagnosed of Sezary's syndrome are reported. The chromosomal study was made after 72 hours of culture of phytohaemagglutinin-stimulated peripheral blood. The 7 patients had abnormal karyotypes, the numeral alterations involving chromosomes 10 and 13, whereas the structural abnormalities affected chromosomes 1, 2, 4, 6 and 14. The large-cell variant has been associated with tetraploidy and the small-cell variant with diploidy, but this fact was not confirmed in the present series.
Solé
F
F
Laboratori de Citologia Hematològica, Hospital Central l'Aliança, Barcelona.
Woessner
S
S
Vallespí
T
T
Domingo
A
A
Pérez Losada
A
A
Florensa
L
L
Irriguible
D
D
Espinet
B
B
Sans-Sabrafén
J
J
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D012751:Sezary Syndrome / Q000235:genetics*
Alteraciones citogenéticas en siete pacientes con síndrome de Sézary.