title: Fever and rigors as sole symptoms of azathioprine hypersensitivity.
abstract: The case history of a haemodialysis patient with fever and rigors is presented. This diagnostic problem turned out to be a hypersensitivity reaction to azathioprine, with identical complaints recurring after a rechallenge with azathioprine, findings which resolved on discontinuation of this drug. The more extended indications for use of azathioprine warrant attention to the possibility of side-effects like drug fever.
authors.affiliation: Department of Internal Medicine and Nephrology, St. Clara Hospital, Rotterdam, Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Smak Gregoor
authors.forename: J L
authors.initials: JL
authors.lastname: van Saase
authors.forename: W
authors.initials: W
authors.lastname: Weimar
authors.forename: P
authors.initials: P
authors.lastname: Kramer
mesh_terms: D001379:Azathioprine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012768:Shivering
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine