Effect of oleanolic acid on complement in adjuvant- and carrageenan-induced inflammation in rats.
The present work was aimed at evaluating the influence of oleanolic acid on complement-related inflammation. In adjuvant-induced arthritis and carrageenan-induced paw oedema in rats, oleanolic acid was found to possess significant anti-inflammatory and complement-inhibitory activities. The intraperitoneal injection of oleanolic acid (60 mg kg-1, twice a day), before and after Freund's Complete Adjuvant challenge and thereafter repeated for several days, significantly reduced foot-pad thickness of experimental animal models and simultaneously reduced complement activity. Oleanolic acid also produced marked reduction in complement levels and inflammatory effects on carrageenan-induced paw oedema in rats when injected intraperitoneally (60 mg kg-1, twice a day).
Kapil
A
A
Pharmacology Division, Regional Research Laboratory, Jammu Tawi, India.
Sharma
S
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D002351:Carrageenan; D003169:Complement Inactivator Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005620:Freund's Adjuvant; D006614:Hindlimb / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000893:Anti-Inflammatory Agents; D003169:Complement Inactivator Proteins; D009828:Oleanolic Acid; D002351:Carrageenan; D005620:Freund's Adjuvant