title: Regression of coronary artery disease: the role of plaque biology.
abstract: Research has lead to a better understanding of the pathophysiology and history of atherosclerotic heart disease, which has reached epidemic proportions in industrialized countries in this century. Atherosclerosis should be seen as a chronic, protracted process that encompasses complex and dynamic interactions between cellular, biochemical, and biophysical factors in the microcosmos of the arterial vessel wall and blood circulation. In this context, the ultimate consequences of this disease process, namely coronary artery disease, must be seen as the "tip of the iceberg." The most dramatic manifestation of coronary artery disease, the acute coronary syndrome, usually occurs as the result of different forces and factors, which lead to abrupt plaque disruption, rupture, and vessel thrombosis. In contrast, the genesis of this atherosclerotic lesion is a slow process. Despite considerable experimental clinical evidence accrued during the past decade, atherosclerosis remains a complex pathophysiological process that is not fully understood. It is clear, however, that the interaction between the cellular elements of the vessel wall and the circulation are the determinants of atheroma formation. In this regard, the vascular endothelium appears to play a pivotal role because of its strategic location and metabolic activity. Antilipidemic therapy influences the outcome of coronary disease through a variety of mechanisms, including direct and indirect effects on the endothelium.
authors.affiliation: Department of Medicine, University of Miami School of Medicine, Fla., USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Valle
authors.forename: G A
authors.initials: GA
authors.lastname: Valle
authors.forename: L
authors.initials: L
authors.lastname: Lemberg
mesh_terms: D003324:Coronary Artery Disease / Q000503:physiopathology / Q000628:therapy*; D018752:Diet, Fat-Restricted; D004730:Endothelium, Vascular / Q000503:physiopathology; D015444:Exercise; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D000960:Hypolipidemic Agents