[Neutron capturing irradiation: principle, current results and perspectives].
Neutron capture irradiation aims to selectively destroy the tumoral cells with nuclear reactions produced inside themselves. Therefore, 10B is selectively carried into tumours, being linked to a molecular vehicle. The tissues are then irradiated with thermal neutrons, and the boron neutron capture leads to the formation of alpha and 7Li particles which produce high levels of radiolytic damage along their range of 10 microns. Boron neutron capture therapy (BNCT) uses a thermal/epithermal neutron beam for irradiation, while boron neutron capture potentiation uses the addition of the captures in a fast neutron irradiation. A first trial, conducted in 1951 to 1961 in the USA to test BNCT on patients suffering of glioblastoma, was a failure, essentially because 10B was located in the cerebral capillaries rather than in the tumoral cells. Today, with great improvement in the boronated compounds which show an uptake preferentially inside the cells; the quality of neutron beams; and the knowledge of the microdosimetry of the technique, this technique may be clinically used to increase the local control of radioresistant tumours, like the high grade gliomas, cutaneous or uveal melanoma, and perhaps soft tissue sarcomas.
Pignol
J P
JP
Service de radiothérapie, centre Antoine-Lacassagne, Nice, France.
Chauvel
P
P
D001894:Borohydrides / Q000627:therapeutic use; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods / Q000639:trends; D002470:Cell Survival / Q000528:radiation effects; D004337:Drug Carriers; D006801:Humans; D018499:Linear Energy Transfer; D009369:Neoplasms / Q000532:radiotherapy*; D009688:Nuclear Reactors; D010315:Particle Accelerators; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D013438:Sulfhydryl Compounds / Q000627:therapeutic use
D001894:Borohydrides; D001896:Boron Compounds; D004337:Drug Carriers; D011838:Radiation-Sensitizing Agents; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D010649:Phenylalanine; C033685:4-boronophenylalanine
Irradiations par capture de neutrons: principe, résultats actuels et perspectives.