title: Cytomegalovirus-induced thrombocytopenia and haemolysis in an immunocompetent adult.
abstract: We describe a patient with severe symptomatic thrombocytopenia and haemolytic anaemia caused by cytomegalovirus (CMV) infection. As far as we know, this is the second case in the literature. Treatment with ganciclovir seemed to be more effective for thrombocytopenia than treatment with corticosteroids. The hypothetical mechanisms leading to thrombocytopenia and haemolysis in CMV infection are briefly discussed. In cases of acute thrombocytopenia and clinical manifestations of an infectious disease, with or without haemolysis, testing for CMV may be useful in connection with therapeutic consequences.
authors.affiliation: Department of Internal Medicine, Catharina Hospital, Eindhoven, The Netherlands.
authors.forename: D J
authors.initials: DJ
authors.lastname: van Spronsen
authors.forename: W P
authors.initials: WP
authors.lastname: Breed
mesh_terms: D000208:Acute Disease; D000743:Anemia, Hemolytic / Q000188:drug therapy / Q000821:virology*; D003586:Cytomegalovirus Infections / Q000150:complications*; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D008875:Middle Aged; D013921:Thrombocytopenia / Q000188:drug therapy / Q000821:virology*
chemical_list: D003907:Dexamethasone; D015774:Ganciclovir