title: Use of molecular analysis in pathophysiological investigation of late-onset neonatal Escherichia coli meningitis.
abstract: We describe one case of late-onset neonatal Escherichia coli meningitis associated with urinary tract infection. Two genotypic methods revealed that the E. coli isolates obtained from blood, feces, and cerebrospinal fluid shared the same pattern, which was different from the unique pattern obtained for the isolates recovered from the urine and the tracheal aspirate. Our study supports passage of bacteria through the gastrointestinal mucosa to the bloodstream as the initial event, with subsequent meningeal localization.
authors.affiliation: Service de Microbiologie, Hôpital Robert Debré, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: A
authors.initials: A
authors.lastname: Bedu
authors.forename: N
authors.initials: N
authors.lastname: Brahimi
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
mesh_terms: D015373:Bacterial Typing Techniques; D001483:Base Sequence; D004927:Escherichia coli Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications / Q000209:etiology* / Q000382:microbiology; D008969:Molecular Sequence Data; D019105:Random Amplified Polymorphic DNA Technique; D014552:Urinary Tract Infections / Q000150:complications / Q000382:microbiology