Expression of an ovine growth hormone transgene in mice causes organomegaly and hepatic lesions which resolve following transgene inactivation.
Sharp
K R
KR
Animal Resources Service, University of California at Davis 95616, USA.
Knudsen
D E
DE
Pomp
D
D
Murray
J D
JD
D000818:Animals; D001835:Body Weight; D048429:Cell Size; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D013006:Growth Hormone / Q000096:biosynthesis / Q000235:genetics*; D006529:Hepatomegaly / Q000473:pathology / Q000662:veterinary; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D009929:Organ Size; D011247:Pregnancy; D012376:Rodent Diseases / Q000209:etiology* / Q000473:pathology; D012756:Sheep / Q000235:genetics; D013163:Splenomegaly / Q000473:pathology / Q000662:veterinary; D019076:Transgenes / Q000235:genetics*
D013006:Growth Hormone