title: ISIS 4: clinical controversy regarding magnesium infusion, thrombolytic therapy, and acute myocardial infarction.
abstract: Magnesium (Mg) infusions over 24 hours were given to patients with suspected acute myocardial infarction (AMI) at least 2 hours after thrombolysis. Patients showed no benefit and even some increased risk in contrast to reduction in mortality obtained by Mg therapy in smaller trials. Results of all of the studies were pooled and statistically analyzed, according to a fixed-effects model that is inappropriate for studies of different protocols. The panel concluded that further study of Mg in AMI is not needed. This conclusion has been questioned.
authors.affiliation: Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Seelig
mesh_terms: D014943:Global Health; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D012307:Risk Factors; D015912:Thrombolytic Therapy
chemical_list: D008274:Magnesium