Effect of pyrethroids on pentobarbital-induced sleeping time in relation to the chemical structure.
The effect of pyrethroids on pentobarbital-induced sleeping time was examined in mice. Pentobarbital-induced sleeping time was defined as the time interval from loss of righting reflex to reappearance of righting reflex. Mice were administered pyrethroids orally 2 h before the intraperitoneal injection of pentobarbital at a dose of 45 mg/kg. Pyrethroids with a cyano group on the alcohol moiety, such as cyphenothrin, cypermethrin, fenvalerate and fenpropathrin shortened the pentobarbital-induced sleeping time, while pyrethroids with an ethynyl group on the acid moiety, such as prallethrin, furamethrin and empenthrin, prolonged sleeping time. Pyrethroids with neither a cyano nor an ethynyl group had no effect on sleeping time. We, thus, found a clear relationship between the chemical structure of pyrethroids and their effect on pentobarbital-induced sleeping time.
Tsuji
R
R
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Osaka, Japan.
Isobe
N
N
Kawasaki
H
H
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007306:Insecticides / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010424:Pentobarbital / Q000494:pharmacology; D011722:Pyrethrins / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D012890:Sleep / Q000187:drug effects*; D013329:Structure-Activity Relationship
D006993:Hypnotics and Sedatives; D007306:Insecticides; D011722:Pyrethrins; D010424:Pentobarbital