title: Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma.
abstract: We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.
authors.affiliation: Department of Radiology, Institut Gustave Roussy, Villejuif, France.
authors.forename: M
authors.initials: M
authors.lastname: Michel
authors.forename: F
authors.initials: F
authors.lastname: Vincent
authors.forename: R
authors.initials: R
authors.lastname: Sigal
authors.forename: G
authors.initials: G
authors.lastname: Damaj
authors.forename: T A
authors.initials: TA
authors.lastname: Bensousan
authors.forename: B
authors.initials: B
authors.lastname: Leclercq
authors.forename: B
authors.initials: B
authors.lastname: Escudier
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D007376:Interleukin-2