YM-47141 and YM-47142, new elastase inhibitors produced by Flexibacter sp. Q17897. II. Structure elucidation.
YM-47141 and YM-47142 are new elastase inhibitor produced by Flexibacter sp. Q17897. These structures were elucidated by MS and NMR spectral analysis. YM-47141 and YM-47142 were the cyclic peptides containing tricarbonyl moiety hydrated on the center carbonyl carbon in DMSO-d6.
Orita
M
M
Molecular Chemistry Research Lab, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan.
Yasumuro
K
K
Kokubo
K
K
Shimizu
M
M
Abe
K
K
Tokunaga
T
T
Kaniwa
H
H
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
D010456:Peptides, Cyclic; D015842:Serine Proteinase Inhibitors; C097796:YM 47141; C097797:YM 47142; D010196:Pancreatic Elastase