title: Double chamber ventricular assist device with a roller screw linear actuator driven by left and right latissimus dorsi muscles.
abstract: A double chamber ventricular assist device (VAD) with a roller screw linear muscle actuator (RSLMA) driven by the left and right latissimus dorsi muscles was developed. The inflow port of each chamber was connected to form the compound inflow port, and the outflow ports were connected to form the compound outflow port. The advantages of this system include 1) the contraction of each muscle contributes to ejection from each ventricle into the common outflow port, thus doubling the net outflow; 2) through proper adjustment of muscle length, the preload to each muscle can be optimized to yield the maximum muscle force; 3) muscle can be stimulated at a lower rate to reduce fatigue and to optimize muscle performance; and 4) the compliance chamber needed in the implantable VAD system is not required with this system. In vitro evaluation in the mock loop with the human arm actuating the RSLMA revealed that the double chamber VAD can provide pump flows of 2-4 L/min against an afterload of 100 mmHg at a stimulation rate of 35-50 beats per minute. The power requirement for each muscle ranged from 2.5 to 3 W at a muscle stroke length of 4 cm. These results verify that the double chamber VAD with the RSLMA driven by the left and right latissimus dorsi muscles can meet the design requirements of a muscle driven VAD to assist the left heart.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Takatani
authors.forename: Y
authors.initials: Y
authors.lastname: Takami
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: G
authors.initials: G
authors.lastname: Jacobs
authors.forename: Y
authors.initials: Y
authors.lastname: Nose
mesh_terms: D001674:Bioelectric Energy Sources; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D001794:Blood Pressure; D004566:Electrodes; D004582:Electronics, Medical; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000502:physiology*