Myopathy and HIV infection.
Skeletal muscle involvement may occur at all stages of HIV infection. The most simple classification of muscular disorders in HIV-infected patients is 1) HIV-associated myopathies, 2) zidovudine myopathy, 3) HIV wasting syndrome, and 4) opportunistic infections and tumoral infiltrations of muscle. Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome c oxidase are helpful in correctly classifying a myopathy as HIV polymyositis or zidovudine myopathy. Studies of cytokine expression in HIV-infected patients and of supplementation with compounds such as carnitine or micronutrients such as selenium might yield new insights into the pathogenesis and treatment of the various AIDS-associated muscular disorders.
Chariot
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P
Groupe de Recherche en Pathologie Neuromusculaire, Hôpital Henri Mondor, Créteil, France.
Gherardi
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R
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000175:diagnosis; D000818:Animals; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D006801:Humans; D009135:Muscular Diseases / Q000175:diagnosis / Q000821:virology*