Correlations between lipid peroxide and glutathione levels in vitamin C supplemented fasting guinea pigs.
The object of this study was to investigate correlations between lipid peroxide (MDA) and glutathione (GSH) levels in liver, kidney, heart and brain of guinea pigs during fasting (24 h, 48 h, 120 h) and respectively by supplementation (A single dose, 500 mg/kg bw, ip) of vitamin C (AA, Ascorbic acid) on fasting (24 h, 48 h, 120 h). MDA and GSH levels of various tissues by fasting and AA supplemented fasting were dependent on the function of each tissue during the fasting period. Lipid peroxide (LP) levels of kidney, heart and brain decreased for the AA supplemented fasting period. However, LP levels of liver increased in the AA supplemented 48 h and 120 h fasting groups. GSH levels of all tissues were affected differently in all of the AA supplemented fasting periods.
Kaplan
B
B
Department of Physiology, Medical Faculty, Gazi University, Ankara, Türkey.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D005215:Fasting / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D006168:Guinea Pigs; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism
D000975:Antioxidants; D008054:Lipid Peroxides; D008315:Malondialdehyde; D005978:Glutathione; D001205:Ascorbic Acid