Danazol versus a gonadotropin-releasing hormone agonist as preoperative preparation for hysteroscopic metroplasty.
OBJECTIVE
To compare the efficacy of danazol and a GnRH agonist as preoperative preparation for hysteroscopic metroplasty in women with septate uterus.


METHODS
Prospective randomized clinical study.


METHODS
Tertiary care center.


METHODS
Thirty patients with septate uterus.


METHODS
The patients were randomized to treatment with danazol 600 mg/d for 2 to 4 weeks (n = 15) or with leuprolide acetate depot 3.75 mg for 2 months (n = 15) as preoperative therapy for hysteroscopic metroplasty.


METHODS
At the intervention the hysteroscopist evaluated difficulty in dilation of the cervical canal, presence of endometrial fragments, bleeding, difficulty in maneuvering the resectoscope, and operating time.


RESULTS
Both the treatments were well tolerated. Metroplasty was simpler overall in the danazol group and also faster in introducing the resectoscope through the cervical canal and maneuvering it in the uterine cavity were both easier. Bleeding was modest in both groups and the anatomic outcome of the operation was similar.


CONCLUSIONS
Short preoperative preparation with danazol results in favorable operating conditions at limited costs with minimal side effects.
Fedele
L
L
Department of Obstetrics and Gynecology, University of Milan, Italy.
Bianchi
S
S
Gruft
L
L
Bigatti
G
G
Busacca
M
M
D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D016729:Leuprolide / Q000627:therapeutic use*; D011300:Preoperative Care; D011446:Prospective Studies; D014599:Uterus / Q000601:surgery*
D004965:Estrogen Antagonists; D016729:Leuprolide; D003613:Danazol