[Acute tubular necrosis in patients after kidney transplantation: associated factors and impact on functional survival of the graft].
Acute tubular necrosis (ATN) represents a serious problem in kidney transplantation. We have reviewed the causes and effects of ATN on kidney transplant patients treated in our hospital between June 1981 and December 1992. We analyzed 359 consecutive kidney transplants performed in 338 patients (213 male and 125 female). There were 311 first grafts. The actuarial functional graft survival (AFGS) was 85% at 1 year and 58.2% at 10 years. The incidence of long-term chronic rejection, the 1-year creatinine blood level (CBL) and the AFGS are summarized: [table: see text] The donor age and the PRA level were significantly correlated with ATN occurrence. ATN after transplantation was associated with a poorer function and survival of the kidney graft. Better donor and patient selection could decrease the occurrence of ATN, thus improving the graft outcome.
Bergeron
E
E
Unité de Transplantation, Hôpital Notre-Dame, Montréal, Québec, Canada.
Aboujaoudé
M
M
Saint-Louis
G
G
Corman
J
J
Smeeters
C
C
Daloze
P
P
D002170:Canada / Q000453:epidemiology; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000601:surgery; D005260:Female; D005921:Glomerulonephritis / Q000601:surgery; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality*; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology / Q000401:mortality*; D008297:Male; D009395:Nephritis, Interstitial / Q000601:surgery; D011183:Postoperative Complications; D017211:Treatment Failure
Nécrose tubulaire aiguë chez les transplantés rénaux: facteurs associés et impact sur la survie fonctionnelle de la greffe.