Antibiotic GE37468 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
GE37468 A is a novel antibiotic produced by Streptomyces sp. ATCC 55365. It has molecular mass 1309.48 and formula C59H52O12N14S5 and belongs to the thiazolyl peptide group of antibiotics. The structure was elucidated by 1H and 13C NMR and MS studies on intact molecule and its hydrolysis products. The antibiotic is a highly modified peptide containing a macrocycle and a side chain composed of a thiazole ring and two dehydroalanine units.
Ferrari
P
P
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (VA), Italy.
Colombo
L
L
Stella
S
S
Selva
E
E
Zerilli
L F
LF
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D011232:Chemical Precipitation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010444:Peptide Elongation Factor Tu / Q000037:antagonists & inhibitors; D010456:Peptides, Cyclic / Q000737:chemistry*; D011500:Protein Synthesis Inhibitors / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*; D013844:Thiazoles / Q000737:chemistry*
D000900:Anti-Bacterial Agents; C096599:GE 37468 A; D010456:Peptides, Cyclic; D011500:Protein Synthesis Inhibitors; D013844:Thiazoles; D010444:Peptide Elongation Factor Tu