Absorption of a new oral formulation of cyclosporin A in a child on parenteral nutrition.
A 2-year-old child underwent renal transplantation in the presence of a post-viral enteropathy rendering him dependent on total parenteral nutrition. As part of his immunosuppression, he was given a new oral formulation of cyclosporin A (Neoral), which he was able to absorb satisfactorily, using conventional doses, during the 6 weeks he was dependent on intravenous nutrition and in the face of intermittent severe diarrhoea. An unusual pharmacokinetic profile was observed.
Jewkes
F E
FE
Department of Child Health, Cardiff Royal Infirmary, Wales, UK.
Jenkins
H R
HR
Lord
R
R
Verrier Jones
K
K
D000284:Administration, Oral; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D010289:Parenteral Nutrition, Total; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000378:metabolism / Q000628:therapy*
D007166:Immunosuppressive Agents; D016572:Cyclosporine