title: Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A.
abstract: Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.
authors.affiliation: Department of Neurosurgery, North Staffordshire Hospital, Stoke-on-Trent, Staffordshire, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Inskip
authors.forename: J
authors.initials: J
authors.lastname: Elexperu-Camiruaga
authors.forename: N
authors.initials: N
authors.lastname: Buxton
authors.forename: P S
authors.initials: PS
authors.lastname: Dias
authors.forename: J
authors.initials: J
authors.lastname: MacIntosh
authors.forename: D
authors.initials: D
authors.lastname: Campbell
authors.forename: P W
authors.initials: PW
authors.lastname: Jones
authors.forename: L
authors.initials: L
authors.lastname: Yengi
authors.forename: J A
authors.initials: JA
authors.lastname: Talbot
authors.forename: R C
authors.initials: RC
authors.lastname: Strange
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000378:metabolism; D050981:Erythroid-Specific DNA-Binding Factors; D005091:Exons; D017353:Gene Deletion; D005787:Gene Frequency; D008040:Genetic Linkage; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014157:Transcription Factors / Q000378:metabolism; D050986:YY1 Transcription Factor
chemical_list: D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D014157:Transcription Factors; D050986:YY1 Transcription Factor; C494698:YY1 protein, human; D005982:Glutathione Transferase