Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
Linnen
J
J
Genelabs Technologies, Redwood City, CA 94063, USA.
Wages
J
J
Zhang-Keck
Z Y
ZY
Fry
K E
KE
Krawczynski
K Z
KZ
Alter
H
H
Koonin
E
E
Gallagher
M
M
Alter
M
M
Hadziyannis
S
S
Karayiannis
P
P
Fung
K
K
Nakatsuji
Y
Y
Shih
J W
JW
Young
L
L
Piatak
M
M
Hoover
C
C
Fernandez
J
J
Chen
S
S
Zou
J C
JC
Morris
T
T
Hyams
K C
KC
Ismay
S
S
Lifson
J D
JD
Hess
G
G
Foung
S K
SK
Thomas
H
H
Bradley
D
D
Margolis
H
H
Kim
J P
JP
D000208:Acute Disease; D000595:Amino Acid Sequence; D001483:Base Sequence; D001782:Blood Donors; D017848:Blood-Borne Pathogens; D002908:Chronic Disease; D003001:Cloning, Molecular; D016384:Consensus Sequence; D018562:Disease Transmission, Infectious; D018067:Flaviviridae / Q000235:genetics; D016679:Genome, Viral; D006518:Hepatitis Viruses / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012328:RNA Viruses / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D016415:Sequence Alignment; D065227:Transfusion Reaction; D014481:United States / Q000453:epidemiology; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics; D014766:Viremia / Q000453:epidemiology / Q000821:virology
D012367:RNA, Viral; D014764:Viral Proteins