Cooperativity: over the Hill.
Cooperativity, the ability of ligand binding at one site on a macromolecule to influence ligand binding at a different site on the same macromolecule, is a fascinating biological property that is often poorly explained in textbooks. The Hill coefficient is commonly used in biophysical studies of cooperative systems although it is not a quantitative measure of cooperativity. The free energy of interaction between binding sites (delta delta G) is a more stringent definition of cooperativity and provides a direct quantitative measure of how the binding of ligand at one site affects the ligand affinity of another site.
Forsén
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Lund University, Chemical Centre, Sweden.
Linse
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D001665:Binding Sites; D064026:Calbindins; D002118:Calcium; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008024:Ligands; D008433:Mathematics; D064030:S100 Calcium Binding Protein G / Q000737:chemistry / Q000378:metabolism; D013816:Thermodynamics
D064026:Calbindins; D008024:Ligands; D064030:S100 Calcium Binding Protein G; D002118:Calcium