Chronobiologic aspects of urinary gonadotropin peptide (UGP).
When using urinary gonadotropin peptide (UGP) as a marker for ovarian cancer, a circadian rhythm of large amplitude is best assessed for improving preanalytic quality control, for specifying how often and when to sample and for resolving chronobiologic endpoints. In a patient (EH, 73 y) with an ovarian (Müllerian) adenocarcinoma, overall high UGP values occurred consistently around 07:00 (standard deviation, SD = 2 h), similar to the timing observed in a presumably healthy woman. The circadian rhythm of EH averages in amplitude about 45% of the daily mean value (SD = 15%). The results indicate the desirability of deriving time-specified reference limits in health for an improved diagnostic value of UGP. The circadian UGP pattern awaits tests of applications for a chronodiagnosis of ovarian cancer, for optimizing treatment efficacy by timing according to rhythms, and conceivably for detecting earliest precancer risk.
Cornélissen
G
G
University of Minnesota, Minneapolis 55455, USA.
Halberg
F
F
Walker
R
R
Zaslavskaya
R M
RM
Fine
R L
RL
Haus
E
E
D000368:Aged; D014408:Biomarkers, Tumor / Q000652:urine*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D002909:Chronobiology Phenomena / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*
D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; C063554:urinary gonadotropin fragment