title: Distortion product otoacoustic emissions in the elderly.
abstract: Clinical interest in otoacoustic emissions (OAEs) is increasing. These can be elicited rapidly in a number of test paradigms that reflect the functional status of the outer hair cells of the organ of Corti. Distortion product otoacoustic emissions (DPOEs) have been well described in infants, and adults, but not in the elderly. The value of DPOE testing as a means of objective assessment of cochlear function is still being studied. The authors obtained DPOEs in 129 ears of 71 elderly volunteer subjects (age 56-93 yr) and in 16 ears of eight young adults (age 19-26 yr) with normal pure-tone thresholds (PTTs). The relation between DPOEs and PTTs, as expressed by the r2 statistic, was 0.18, 0.46, and 0.30 at 1, 2, and 4 kHz, respectively. Amplitudes of DPOEs did not decrease significantly with age, when adjusted for PTTs. Sensitivity and specificity, receiver operating characteristic curves, as well as posterior probabilities were analyzed to elucidate the relation between DPOEs and PTTs. At 2 kHz 90 percent of ears with PTTs 40 dB HL or less exhibited DPOEs of -4 dB SPL or greater, and all ears with PTTs greater than 40 dB HL had either no measurable DPOEs or DPOE amplitude less than 4 dB SPL.
authors.affiliation: St. Louis Children's Hospital, Missouri, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Karzon
authors.forename: P
authors.initials: P
authors.lastname: Garcia
authors.forename: J L
authors.initials: JL
authors.lastname: Peterein
authors.forename: G A
authors.initials: GA
authors.lastname: Gates
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone / Q000379:methods* / Q000592:standards; D001309:Auditory Threshold; D005260:Female; D006311:Hearing Disorders / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity