title: Three-dimensional simulation of epicardial potentials using a microcomputer-based heart-torso model.
abstract: Previous cardiac simulation studies have focused on simulating the activation isochrones and subsequently the body surface potentials. Epicardial potentials, which are important for clinical applications as well as for electrocardiography inverse problem studies, however, have usually been neglected. This paper presents a procedure of simulating epicardial potentials using a microcomputer-based heart-torso model with real geometry. The heart model developed earlier which was composed of more than 60,000 cell units was used in this study. To simulate the epicardial potentials, an epicardial surface model which enclosed the whole heart was constructed. The heart model, together with the epicardial surface model, are mounted in an inhomogeneous human torso model. Electric dipoles, which are proportional to the spatial gradient of the action potential, are generated in all cell units. These dipoles give rise to a potential distribution on the epicardial surface, which is calculated by means of the boundary element method. The simulated epicardial potential maps during a normal heart beat and in patients with left bundle branch block (LBBB) are in close agreement with those reported in the literature.
authors.affiliation: Institute of Biomedical Engineering, Zhejiang University, Hangzhou, P.R., China.
authors.forename: W
authors.initials: W
authors.lastname: Lu
authors.forename: L
authors.initials: L
authors.lastname: Xia
mesh_terms: D000200:Action Potentials; D000465:Algorithms; D018780:Body Surface Potential Mapping / Q000379:methods* / Q000706:statistics & numerical data; D002037:Bundle-Branch Block / Q000175:diagnosis; D003198:Computer Simulation; D006321:Heart / Q000502:physiology*; D006801:Humans; D008838:Microcomputers; D008955:Models, Cardiovascular; D012016:Reference Values