title: 27-O-demethylrapamycin, an immunosuppressant compound produced by a new strain of Streptomyces hygroscopicus.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Box
authors.forename: P R
authors.initials: PR
authors.lastname: Shelley
authors.forename: J W
authors.initials: JW
authors.lastname: Tyler
authors.forename: M S
authors.initials: MS
authors.lastname: Verrall
authors.forename: S R
authors.initials: SR
authors.lastname: Warr
authors.forename: A M
authors.initials: AM
authors.lastname: Badger
authors.forename: M A
authors.initials: MA
authors.lastname: Levy
authors.forename: R M
authors.initials: RM
authors.lastname: Banks
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003208:Concanavalin A / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011994:Recombinant Proteins / Q000378:metabolism; D020123:Sirolimus; D013154:Spleen / Q000166:cytology; D013302:Streptomyces / Q000378:metabolism*; D022021:Tacrolimus Binding Proteins
chemical_list: C097851:27-O-demethylrapamycin; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D011090:Polyenes; D011714:Pyrans; D011994:Recombinant Proteins; D003208:Concanavalin A; D022021:Tacrolimus Binding Proteins; D020123:Sirolimus