[Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma].
BACKGROUND
While cigarette smoking and alcohol consumption have been linked to laryngeal carcinoma, the role of genetic factors in determining individual susceptibility is unknown. We describe the role of allelism at glutathione-S-transferase GSTM1, GSTT1, and cytochrome P 450 CYP2D6 loci in determining individual susceptibility to laryngeal squamous cell carcinoma.


METHODS
Enzyme genotypes were determined using the polymerase chain reaction in 169 patients suffering T1-T4 laryngeal carcinoma and in 145 controls.


RESULTS
While the frequency of the heterozygote GSTM1 A/B genotype was statistically significantly lower in the cases than controls, the frequency of the GSTT1 null genotype was higher in cases than controls.


CONCLUSIONS
These initial data suggest that allelism at GST loci mediates susceptibility to squamous cell carcinoma of the larynx. Thus, GSTM1 A/B appears to be associated with a reduced risk while GSTT1 null confers increased risk. The findings are compatible with the view that genetic predisposition is important in determining risk of this cancer.
Jahnke
V
V
Hals-Nasen-Ohren-Klinik und Poliklinik des Virchow-Klinikums der Humboldt-Universität zu Berlin.
Strange
R
R
Matthias
C
C
Fryer
A A
AA
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D003043:Cocarcinogenesis; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D005819:Genetic Markers; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D005982:Glutathione Transferase
Erste Ergebnisse über Glutathion-S-Transferase GSTM1 and GSTT1 Genotypen und die genetische Prädisposition beim Larynxkarzinom.