Long-term survival of four dogs with disseminated Aspergillus terreus infection treated with itraconazole.
Four dogs with disseminated aspergillosis caused by Aspergillus terreus were treated with oral itraconazole for 190 to 1095 days. Infection was eliminated in 1 dog. Two dogs were treated for 1000 and 1095 days but were eventually euthanased 572 and 485 days after treatment was stopped. At necropsy both dogs had widespread aspergillosis. The fourth dog was euthanased for other reasons after 190 days of treatment when it was showing a good clinical response although there was radiographic evidence that the disease was progressing.
Kelly
S E
SE
School of Veterinary Studies, Murdoch University, Western Australia.
Shaw
S E
SE
Clark
W T
WT
D000818:Animals; D000935:Antifungal Agents / Q000592:standards / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D001230:Aspergillus / Q000302:isolation & purification; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D004285:Dogs; D005065:Euthanasia / Q000662:veterinary; D005260:Female; D017964:Itraconazole / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D015996:Survival Rate; D013997:Time Factors; D014556:Urine / Q000382:microbiology
D000935:Antifungal Agents; D017964:Itraconazole