title: Lack of progression of neurologic deficit in survivors of paralytic polio: a 5-year prospective population-based study.
abstract: We completed a prospective, population-based cohort study of polio survivors in Olmsted County, Minnesota, between 1986 and 1993. We identified 50 individuals who had had paralytic polio between 1935 and 1960, as representative of all 300 cases of paralytic polio in the county. We completed detailed quantitative clinical and electrophysiologic studies at entry and after 5 years. These studies demonstrated stable neuromuscular function within the cohort, although 60% of the individuals were symptomatic. In two-thirds of the symptomatic patients, the causes of their symptoms were unrelated to earlier polio. For the 20% of patients who had unexplained muscle pain, perception of weakness, and fatigue, a mechanical disorder most likely underlies their symptoms.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Windebank
authors.forename: W J
authors.initials: WJ
authors.lastname: Litchy
authors.forename: J R
authors.initials: JR
authors.lastname: Daube
authors.forename: R A
authors.initials: RA
authors.lastname: Iverson
mesh_terms: D000200:Action Potentials / Q000502:physiology; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D011051:Poliomyelitis / Q000503:physiopathology*; D011446:Prospective Studies; D011795:Surveys and Questionnaires