TUDCA and UDCA are incorporated into hepatocyte membranes: different sites, but similar effects.
The aim of this paper is to point out that: 1) CDCA and DCA increase the polarity of cell membranes and cause the release of cholesterol and phospholipid from the membranes; 2) the extent of this damage is inversely correlated with the cholesterol content of the membrane investigated; 3) UDCA, TUDCA and GUDCA decrease membrane polarity; 4) they prevent membrane damage when added prior to CDCA or DCA; 5) UDCA appears to be incorporated into the apolar domain of the membrane, TUDCA, GUDCA into the interface; 6) UDCA decreases HLA class I expression on hepatocyte membranes; 7) CDCA induces GLDH-release from liver mitochondria and increases mitochondrial membrane polarity and mobility; and 8) UDCA reduces the release of GLDH from mitochondria caused by CDCA.
Leuschner
U
U
Department of Gastroenterology, Johann Wolfgang Goethe Universität, Frankfurt am Main, Germany.
Guldutuna
S
S
Bhatti
S
S
Elze
A
A
Imhof
M
M
You
T
T
Zimmer
G
G
D000818:Animals; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003840:Deoxycholic Acid / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000276:immunology / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D013655:Taurochenodeoxycholic Acid / Q000378:metabolism*; D014580:Ursodeoxycholic Acid / Q000378:metabolism*
D015395:Histocompatibility Antigens Class I; D008563:Membrane Lipids; D010743:Phospholipids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine; D014580:Ursodeoxycholic Acid; D002784:Cholesterol