The rat genes encoding the pancreatitis-associated proteins I, II and III (Pap1, Pap2, Pap3), and the lithostathin/pancreatic stone protein/regeneration protein (Reg) colocalize at 4q33-->q34.
Using fluorescence in situ hybridization, we determined that the three rat PAP genes, and the related REG gene map in the same chromosomes region, namely 4q33-->q34. This rat chromosome region is thus homologous to the human 2p12 region, which also contains the PAP gene, the REG1A gene, and a REG-related gene (REGL).
Stephanova
E
E
Département de Biologie moléculaire, Université Libre de Bruxelles, Rhode-St-Genèse (Belgium).
Tissir
F
F
Dusetti
N
N
Iovanna
J
J
Szpirer
J
J
Szpirer
C
C
D000209:Acute-Phase Proteins / Q000235:genetics*; D000818:Animals; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D017404:In Situ Hybridization, Fluorescence; D037181:Lectins, C-Type; D051847:Lithostathine; D009419:Nerve Tissue Proteins; D000073718:Pancreatitis-Associated Proteins; D051381:Rats / Q000235:genetics*
D000209:Acute-Phase Proteins; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D037181:Lectins, C-Type; D051847:Lithostathine; D009419:Nerve Tissue Proteins; D000073718:Pancreatitis-Associated Proteins; C000612141:REG3A protein, human; C497616:Reg1a protein, rat; C000612146:Reg3a protein, rat; C000612144:Reg3b protein, rat; C000612145:Reg3g protein, rat