title: Replacement of long segments of the esophagus with a collagen-silicone composite tube.
abstract: Artificial esophagi designed thus far can be classified into three types in terms of the materials used: natural, artificial, and composite. In conventional models, even when artificial esophagi were made of ideal materials with high tissue affinity, they remained in the tissue as a foreign body, and therefore were not free of the complications caused by implanted material. The authors have designed a new type of artificial esophagus composed of a Silicone tube covered with nonantigenic collagen. The novel feature of this artificial esophagus is that the prosthesis does not remain in the implanted site, but is replaced by regenerated host tissue. Using this artificial esophagus, the authors have already succeeded in replacing a 5 cm gap in the esophagus. In this study, replacement of longer portions of the esophagus was assessed in seven dogs using a 10 cm long artificial esophagus. Stenosis did not occur in five of the seven dogs and, consequently, these dogs survived by oral feeding alone for more than 6 months without dry weight loss. The other two animals died of anesthetic accidents at the time of stent removal 6 weeks after surgery. In both cases, the internal surface of the neoesophagus was covered with a polylayer of squamous epithelium. Regenerated esophagi had normal esophageal glands and immature muscle tissue. It is therefore concluded that this new artificial esophagus is also applicable for replacement of long segments of esophagus.
authors.affiliation: Department of Artificial Organs, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takimoto
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Teramachi
authors.forename: T
authors.initials: T
authors.lastname: Kiyotani
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D003094:Collagen; D004285:Dogs; D004947:Esophagus / Q000473:pathology / Q000502:physiology / Q000601:surgery; D005069:Evaluation Studies as Topic; D008854:Microscopy, Electron; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012038:Regeneration; D012828:Silicones; D013997:Time Factors
chemical_list: D012828:Silicones; D003094:Collagen