[Effects of selenium and vitamin E on arachidonic acid metabolism in experimental myocardial ischaemia].
Wistar rats were fed with grain produced in the areas prevalent of Keshan Disease, and supplemented by selenium (Se) and vitamin E (VE) for ten weeks, and an acute myocardial ischaemia animal model was established by ligation of left anterior descending coronary arteries. Results indicated activities of phospholipase A2 (PLA2), creatine kinase (CK) and lactate dehydrogenase (LDH), and levels of arachidonic acid (AA), thromboxane A2 (TXA2), leucotriene C4 (LTC4) and lipid peroxides (LPO) increased, but level of prostacyclin (PC) and activities of glutathione peroxidase (GSH-PO), copper-zinc superoxide dismutase (Cu-Zn-SOD) and catalase (CAT) decreased 48 hours after ligation of the coronary vessels in rats without supplement of Se and VE. Supplement of Se or VE in their feed could reverse the above effects and the best results could be got by supplement of both. It suggested that supplement of adequate amount of Se and VE in their feed could affect metabolism of AA and levels of its metabolites, improve myocardial function and metabolic status and reduce myocardial damage in rats under the stress of acute myocardial ischaemia.
Liu
W
W
Institute of Preclinical Sciences Norman Bethune University of Medical Sciences, Changchun.
Li
G
G
Zhang
X
X
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D001095:Arachidonic Acids; D014810:Vitamin E; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D012643:Selenium