title: An improved left ventricular cannula for chronic dynamic blood pump support.
abstract: Ventricular unloading with dynamic blood pumps can be markedly affected by the geometry of the cannula tip within the ventricular chamber. Due to the ability of these pumps to develop significant negative inflow pressure, existing cannula tips designed for passively filling blood pumps can be predisposed to inflow occlusion by intraventricular anatomic structures. A novel "trumpet" mouth cannula was constructed to overcome this limiting problem. This design was based on two criteria: to provide additional stenting to the ventricular apex, and to assure placement of the tip opening relative to the endocardial surface. This prototype cannula was evaluated in vivo against conventional caged, blunt, and tapered designs to assess anatomic and hemodynamic interaction within the ventricular apex. Post mortem examination revealed the inflow tract to be devoid of myocardial obstruction in all cases. These initial studies indicate that a trumpet mouth cannula can provide satisfactory hemodynamic performance required by dynamic blood pumps.
authors.affiliation: University of Pittsburgh, Artificial Heart and Lung Program, Pennsylvania 15219, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Antaki
authors.forename: T J
authors.initials: TJ
authors.lastname: Dennis
authors.forename: H
authors.initials: H
authors.lastname: Konishi
authors.forename: M E
authors.initials: ME
authors.lastname: Brown
authors.forename: T R
authors.initials: TR
authors.lastname: Maher
authors.forename: J P
authors.initials: JP
authors.lastname: Tomczak
authors.forename: J P
authors.initials: JP
authors.lastname: Kerrigan
authors.forename: R L
authors.initials: RL
authors.lastname: Kormos
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization / Q000295:instrumentation* / Q000592:standards; D002408:Catheters, Indwelling / Q000592:standards*; D005240:Feasibility Studies; D005260:Female; D006353:Heart-Assist Devices / Q000592:standards*; D006439:Hemodynamics; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D012756:Sheep; D013927:Thrombosis / Q000517:prevention & control; D016276:Ventricular Function