A new animal model for abdominal aortic aneurysms:initial results using a multiple-wire stent.
OBJECTIVE
The effect of a plain 48-wire self-expanding flexible stent (Wallstent-Schneider (Europe) AG) on abdominal aortic aneurysms has been studied in a new animal model.


METHODS
Aneurysms were created by interposing fusiform segments of glutaraldehyde-tanned bovine internal jugular vein into the infrarenal aortas of 12 Large White pigs. The first six pigs were assessed after 6 weeks by ultrasonography and arteriography; they were then sacrificed for pathological examination. Endovascular placement of the stents, 2 weeks after aneurysm creation, was performed under arteriographic control in the next six pigs. These pigs were assessed by ultrasonography and arteriography 6 weeks after stenting; they were then sacrificed for pathological examination.


RESULTS
At 6 weeks the aneurysms in the first group were pulsatile with partial endothelialisation and no mural thrombus. Placement of the stent in the second group was accomplished easily. Stenting resulted in an immediate reduction in wall pulsatility of all aneurysms and thrombosis of the excluded aneurysm sac occurred in three cases. In the other three cases the pulse pressure in the sac was reduced. In all cases there was a significant reduction in maximum aneurysm diameter when measured 6 weeks after stenting.


CONCLUSIONS
A pulsatile, non-thrombogenic aortic aneurysm model approaching human dimensions has been successfully developed for the study of endoprostheses prior to their clinical use. Endovascular placement of a plain, multiple-wire Wallstent was associated with reductions in aneurysm pulsatility, pulse pressure within the sac and maximum aneurysm diameter over the study period. Stenting was associated with thrombosis of the excluded aneurysm sac in 50% of cases.
Whitbread
T
T
Vascular Unit, Royal Hallamshire Hospital, Sheffield, U.K.
Birch
P
P
Rogers
S
S
Majeed
A
A
Rochester
J
J
Beard
J D
JD
Gaines
P
P
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001027:Aortography; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D015607:Stents; D013552:Swine; D014463:Ultrasonography