Phosalone poisoning on the cation-linked ATPases of central nervous system of Rana tigrina (Daudin).
An acute dose of phosalone, an organophosphate pesticide, widely used in crop fields, injected to Rana tigrina, intraperitoneally, inhibited the different inorganic ion linked ATPase enzymes of the central nervous system (CNS). Six discrete CNS compartments, namely telencephalon, mid-brain, rhombencephalon, cervical spinal cord, thoracic spinal cord and lumbar spinal cord showed markedly diminished ATPase activity. ATPases inhibition affected the neuronal activity and muscular coordination leading to moribund or comatose phase in the poisoned frogs. The specific inhibition of Mg(2+)-ATPase suggests the uncoupling action of the compound in the neuronal tissue. Increased oxygen uptake in the brain regions of phosalone-treated frogs also supports the above uncoupling action.
Balasundaram
K
K
Department of Zoology, Presidency College, Madras, India.
Ramalingam
K
K
Selvarajan
V R
VR
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000187:drug effects / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000187:drug effects / Q000378:metabolism*; D002412:Cations / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects* / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000506:poisoning* / Q000633:toxicity; D007306:Insecticides / Q000506:poisoning* / Q000633:toxicity; D008297:Male; D009946:Organothiophosphorus Compounds / Q000506:poisoning* / Q000633:toxicity; D010101:Oxygen Consumption / Q000187:drug effects; D011898:Ranidae; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism*
D002412:Cations; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C003117:phosalone; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase