Melanin-concentrating hormone gene-related peptide stimulates ACTH, but not alpha-MSH, release from the tilapia pituitary.
Tilapia (Oreochromis mossambicus; teleostei) melanin-concentrating hormone gene-related peptide (tMgrp) was tested for tropic actions on adenocorticotropin hormone (ACTH) and alpha-melanocyte stimulating hormone (alpha-MSH) producing cells in the tilapia pituitary gland in vitro. Up to 100 microM synthetic tilapia Mgrp (tMgrp) had no effect on alpha-MSH release from tilapia neuro-intermediate lobes in a superfusion set up. However, at concentrations above 1 microM, tMgrp concentration dependently stimulated ACTH release from tilapia anterior lobes. This is the first evidence that Mgrp modulates ACTH release from teleost corticotropes, and this might implicate the peptide in the regulation of the pituitary-interrenal axis of fish.
Gröneveld
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Department of Animal Physiology, Faculty of Science, University of Nijmegen, The Netherlands.
Balm
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Wendelaar Bonga
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D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D017210:Tilapia / Q000502:physiology*; D000521:alpha-MSH / Q000378:metabolism
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C097980:melanin-concentrating hormone gene-related peptide, tilapia; D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone