title: The role of chromosome translocations in T cell acute leukemia.
abstract: A variety of unique chromosome translocations are found in the malignant cells of patients with T cell acute lymphoblastic leukemia (T-ALL). Molecular analysis of these translocations has implicated nine different proto-oncogenes in the pathogenesis of T-ALL. Despite the apparent genetic complexity of this disease, recent studies have uncovered a common pathway of T-ALL development that involves two distinct families of transcription factors.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235-9140, USA.
authors.forename: L Y
authors.initials: LY
authors.lastname: Hwang
authors.forename: R J
authors.initials: RJ
authors.lastname: Baer
mesh_terms: D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000378:metabolism; D011519:Proto-Oncogenes; D014157:Transcription Factors / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D014157:Transcription Factors