title: [The correlation of dopamin- and enkephalinergic influences on rat conditioned-reflex activity].
abstract: Behavioural effects of enkephalin microinjections into substantia nigra of rat brain were studied in short time after intrastriatal administration of 6-hydroxydopamine (6-OHDA). It was shown that such microinjections improved conditioned activity of animals. A conclusion was made that the role of enkephalinergic brain structures in compensatory processes in acute period of development of 6-OHDA neurotoxic action was related to increase in efficiency of the mechanisms of self-regulation of dopamine neurons.
authors.forename: N P
authors.initials: NP
authors.lastname: Shugalev
authors.forename: G
authors.initials: G
authors.lastname: Hartman
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004347:Drug Interactions; D004743:Enkephalin, Leucine / Q000008:administration & dosage / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000008:administration & dosage / Q000494:pharmacology; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D008297:Male; D008845:Microinjections; D009498:Neurotoxins / Q000008:administration & dosage / Q000494:pharmacology; D016627:Oxidopamine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D009498:Neurotoxins; D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D016627:Oxidopamine
vernacular_title: Sootnoshenie dofamin- i énkefalinergicheskikh vliianiĭ na uslovnoreflektornuiu deiatel'nost' krys.