[Ultrasonic evaluation of early atherosclerotic damage in patients with type 1 diabetes mellitus].
The aim of this study was to evaluate the influence of metabolic control on the development of atherosclerotic lesions in type 1 insulin-dependent diabetic patients (IDDM).


METHODS
Twenty-eight well controlled IDDM patients, without known risk factors or clinical evidence of cardiovascular disease, together with 28 age-matched healthy controls spontaneously underwent high-resolution echographic evaluation of carotid femoral arteries. A global score of atherosclerotic damage as been assigned to the four investigated vessels on the basis of 1-6 scale, which takes into account most important ultrasound atherosclerotic lesion found in every artery.


RESULTS
Diabetic and healthy controls differed significantly as regard to medio-intimal carotid thickness (p < 0.001), but were similar as for score of atherosclerotic damage.


CONCLUSIONS
Our results suggest that, in spite of a carotid wall medio-intimal thickness more pronounced in IDDM patients, well controlled IDDM is associated with atherosclerotic damage almost identical to that of healthy age-matched controls.
Rossi
M
M
Cattedra e Scuola di Specializzazione in Medicina Interna, Università degli Studi Pisa.
Matteucci
E
E
Vagheggini
G
G
Ruberti
F
F
Galetta
F
F
Uncini Manganelli
C
C
Fiorelli
A
A
Giampietro
O
O
Giusti
C
C
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000000981:diagnostic imaging*; D002339:Carotid Arteries / Q000473:pathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017539:Tunica Intima / Q000473:pathology; D018608:Ultrasonography, Doppler
Valutazione ultrasonografica del danno aterosclerotico precoce in diabetici di tipo 1 insulino-dipendenti.