title: Benign salivary gland tumors: a cytogenetic study of 21 cases.
abstract: Cytogenic findings of 21 benign salivary gland tumors, including 14 pleomorphic adenomas, 5 Warthin's tumors, 1 myoepithelioma, and 1 cystadenoma, are reported. The present study confirms that pleomorphic adenomas characteristically have highly specific rearrangements involving only a few chromosome regions (3p21, 8q12 and 12q13-15) which suggests their specific role in the mixed tumor genesis. Warthin's tumors also show non-random numerical and structural alterations that were concurrent in one of the cases studied. To our knowledge no cytogenetic data are available in myoepitheliomas and cystadenomas. The former reveals a normal karyotype and the latter shows only clonal numerical alterations (gain of chromosomes 2 and 18).
authors.affiliation: Departmento de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisbon, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Martins
authors.forename: I
authors.initials: I
authors.lastname: Fonseca
authors.forename: A
authors.initials: A
authors.lastname: Félix
authors.forename: L
authors.initials: L
authors.lastname: Roque
authors.forename: J
authors.initials: J
authors.lastname: Soares
mesh_terms: D000235:Adenolymphoma / Q000235:genetics; D008949:Adenoma, Pleomorphic / Q000235:genetics; D000328:Adult; D000368:Aged; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000235:genetics*