title: Cholecystokinin changes the duration but not the rate of licking in vagotomized rats.
abstract: Abdominal vagotomy markedly reduces or abolishes the inhibitory effect of cholecystokinin (CCK-8) on meal size. To investigate the rate and microstructure of licking underlying this phenomenon, licking was measured throughout a meal of milk in intact and vagotomized rats after intraperitoneal injections of isotonic saline or CCK-8. CCK-8 increased the slope of the decay of licking, decreased the efficiency of licking, and decreased the duration of licking in intact rats but had no effect on either the slope of the decay of licking or the efficiency of licking, but it increased the duration of licking in vagotomized rats. These results demonstrate that abdominal vagal nerves are necessary for CCK-8 to increase the rate of decay of licking, but nonvagal mechanisms mediate the effect of CCK-8 on duration of licking.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Davis
authors.forename: G P
authors.initials: GP
authors.lastname: Smith
authors.forename: T M
authors.initials: TM
authors.lastname: Kung
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology; D004326:Drinking / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009042:Motivation; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D012844:Sincalide