Chronic UVB irradiation induces superoxide dismutase activity in human epidermis in vivo.
In order to study the effects of repeated UVB exposures on the epidermal antioxidant defence system, we obtained epidermis samples from male volunteers who were exposed to chronic UVB irradiation. Chronic UVB irradiation was shown to be accompanied by induction of epidermal superoxide dismutase (SOD) activity in vivo, while the activities of the other antioxidant enzymes were not significantly changed. The repeated exposure of the epidermis to UVB irradiation was not accompanied by accumulation of products of lipid peroxidation reactions. As superoxide dismutase is of major importance in scavenging the reactive oxygen species, the UVB-induced changes in SOD activity might provide the epidermis a way of defending itself against the effects of chronic UVB irradiation.
Punnonen
K
K
Department of Clinical Chemistry, University Central Hospital of Turku, Finland.
Lehtola
K
K
Autio
P
P
Kiistala
U
U
Ahotupa
M
M
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000528:radiation effects; D002374:Catalase / Q000378:metabolism; D004790:Enzyme Induction / Q000528:radiation effects; D004817:Epidermis / Q000201:enzymology* / Q000528:radiation effects; D005982:Glutathione Transferase / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D015227:Lipid Peroxidation / Q000528:radiation effects; D008297:Male; D010427:Pentose Phosphate Pathway; D013482:Superoxide Dismutase / Q000096:biosynthesis*; D014466:Ultraviolet Rays
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase