Apo B signal peptide insertion/deletion polymorphism is involved in postprandial lipoparticles' responses.
The changes in postprandial concentrations of five lipoparticles (LpC-III, LpC-III:B, LpC-IIInoB, LpA-I and LpA-I:A-II) were studied on 144 apparently healthy (71 male and 73 female) subjects during the 4 h following the ingestion of a 1.260 kJ milkshake. The influence of apo B signal peptide polymorphisms, apo E polymorphism, and other factors including age, gender, BMI, tobacco and alcohol consumption on the postprandial responses of lipoparticles was investigated. Apo-A-I-containing lipoparticles were not influenced during the 4 h following the test meal except for LpA-I:A-II, which decreased in women. LpA-I:A-II is the only particle that showed a gender-dependent change in postprandial concentration. Apo-CIII-containing lipoparticles showed significant postprandial variations. Particles containing both apo B and apo C-III (total LpC-III and LpC-III:B), mainly present in VLDL fraction, had significantly different postprandial responses among the genotypes of the apo B signal peptide polymorphism. Homozygotes for Del allele showed a decrease of LpC-III:B concentrations over the 4 h, whereas Ins/Ins homozygotes and Ins/Del heterozygotes had a peak in concentration at 2 h. The apo B signal peptide polymorphism explained 2.3% of the variance of LpCIII:B, whereas apo E polymorphism did not influence the postprandial concentrations of any lipoparticles.
Régis-Bailly
A
A
Centre de Médecine Préventive, URA CNRS 597, Vandoeuvre-lès-Nancy, France.
Fournier
B
B
Steinmetz
J
J
Gueguen
R
R
Siest
G
G
Visvikis
S
S
D000328:Adult; D000367:Age Factors; D000483:Alleles; D001053:Apolipoproteins / Q000097:blood; D001055:Apolipoproteins B / Q000235:genetics*; D015992:Body Mass Index; D004435:Eating; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D021382:Protein Sorting Signals / Q000235:genetics*; D012737:Sex Factors
D001053:Apolipoproteins; D001055:Apolipoproteins B; D008055:Lipids; D008074:Lipoproteins; D021382:Protein Sorting Signals