title: Rhinocerebral mucormycosis. Therapy with amphotericin B lipid complex.
abstract: Rhinocerebral mucormycosis with intracranial involvement has a high mortality. The standard therapy consists of aggressive surgical débridement accompanied by high doses of amphotericin B deoxycholate. Even with this therapy, the mortality rate has been 48% in the series reported since 1980. We treated a 60-year-old diabetic woman with rhinocerebral mucormycosis involving the cavernous sinus whose infection responded to medical therapy with amphotericin B lipid complex. To our knowledge, this is the only well-documented medical cure of a patient with rhinocerebral mucormycosis and intracranial involvement.
authors.affiliation: University of Arizona, College of Medicine, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Strasser
authors.forename: R J
authors.initials: RJ
authors.lastname: Kennedy
authors.forename: R D
authors.initials: RD
authors.lastname: Adam
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001927:Brain Diseases / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B