title: First-pass contrast-enhanced inversion recovery and driven equilibrium fast GRE imaging studies: detection of acute myocardial ischemia.
abstract: The purpose of this study was (1) to monitor the dynamic effects of T1-enhancing and magnetic susceptibility contrast material on normal canine myocardium using inversion recovery (IR)- and driven equilibrium (DE)-prepared fast gradient-recalled echo (GRE) sequences and (2) to determine the relative value of T1-enhancing and magnetic susceptibility contrast material in detecting regions of ischemia in the same animal. Normal dogs (n = 5) and dogs with acute occlusion of the left anterior descending (LAD) coronary artery (n = 11) were studied using a 1.5-T MR imager. ECG-gated fast IR-prepared GRE images were acquired using TI/TR/TE of 700/7.0/2.9 msec and a flip angle of 7 degrees. Fast DE-prepared GRE images were obtained using a flip angle of 12 degrees and a DE delay/TR/TE of 60/10.2/4.2 msec. Sequential images were acquired to monitor transit of 0.05 mmol/kg gadodiamide injection and 0.2 and 0.4 mmol/kg sprodiamide injection. On slice-nonselective IR fast GRE images, gadodiamide caused significant enhancement of the normal myocardium and the left ventricular (LV) chamber blood. In dogs with LAD occlusion, the ischemic region was defined as an area of low signal intensity (SI). On DE-prepared GRE sequences, administration of sprodiamide resulted in a substantial decrease in signal from normal myocardium and LV chamber blood in normal dogs. In animals subjected to LAD occlusion, this contrast medium produced a transient decrease in SI from normal myocardium (P < .05) and no significant change in SI from ischemic myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Radiology, University of California, San Francisco 94143, USA.
authors.forename: M
authors.initials: M
authors.lastname: Saeed
authors.forename: M F
authors.initials: MF
authors.lastname: Wendland
authors.forename: K
authors.initials: K
authors.lastname: Lauerma
authors.forename: H
authors.initials: H
authors.lastname: Sakuma
authors.forename: W
authors.initials: W
authors.lastname: Chew
authors.forename: N
authors.initials: N
authors.lastname: Derugin
authors.forename: C B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004195:Disease Models, Animal; D004285:Dogs; D017352:Echo-Planar Imaging / Q000379:methods*; D019786:Gadolinium DTPA; D007089:Image Enhancement; D009203:Myocardial Infarction / Q000175:diagnosis*; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid; C064925:gadodiamide; D019786:Gadolinium DTPA