Effect of cisplatin administration on the electrochemical composition of endolymph in the rat cochlea.
The effect of cisplatin on the electrochemical composition of the cochlear endolymph was studied in Long-Evans rats three days after a single intraperitoneal injection (8 mg/kg b.w.). A dose 2/3 of LD50 induced a decrease of the endolymphatic concentration of potassium whereas the endocochlear potential was unaffected. The discrepancy between these two findings indicated that cisplatin did not alter the mechanisms involved in the genesis of the endocochlear potential but modified the passive K transport into endolymph.
Laurell
G
G
Institut National de la Santé et de la Recherche Médicale U251, Department of Physiology, Faculté Xavier Bichat, Université Paris 7, France.
Teixeira
M
M
Sterkers
O
O
Ferrary
E
E
D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003051:Cochlea / Q000737:chemistry / Q000187:drug effects*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004563:Electrochemistry; D004710:Endolymph / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D010498:Perilymph / Q000737:chemistry / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D013316:Stria Vascularis / Q000187:drug effects / Q000378:metabolism
D000970:Antineoplastic Agents; D002945:Cisplatin; D011188:Potassium