Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.
The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentration to induce significant opacification of bovine lenses maintained in vitro. These data suggest that ocular toxic side effects will be minimized by use of the steroidal (ICI 182780) rather than nonsteroidal antioestrogens (tamoxifen).
Zhang
J J
JJ
Department of Physiology, University of Wales, Cardiff.
Jacob
T J
TJ
Hardy
S P
SP
Higgins
C F
CF
Valverde
M A
MA
D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000517:prevention & control; D002417:Cattle; D018118:Chloride Channels / Q000187:drug effects*; D004195:Disease Models, Animal; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives*; D004965:Estrogen Antagonists / Q000009:adverse effects*; D000077267:Fulvestrant; D066298:In Vitro Techniques; D009447:Neuroblastoma; D018408:Patch-Clamp Techniques; D013629:Tamoxifen / Q000009:adverse effects*; D014407:Tumor Cells, Cultured
D018118:Chloride Channels; D004965:Estrogen Antagonists; D013629:Tamoxifen; D000077267:Fulvestrant; D004958:Estradiol