title: A comparative study of the visible light photochemistry of gilvocarcins V and M.
abstract: Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturated dry DMSO was also determined. These values are not different, within experimental error, from those corresponding to gilvocarcin V (GV). Because GV is a strong photocytotoxic agent and GM is not, these results imply that Type I and Type II mechanisms are not important pathways in the cytotoxicity of GV.
authors.affiliation: Department of Chemistry, CUH Station, University of Puerto Rico at Humacao.
authors.forename: A E
authors.initials: AE
authors.lastname: Alegría
authors.forename: L
authors.initials: L
authors.lastname: Zayas
authors.forename: N
authors.initials: N
authors.lastname: Guevara
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000528:radiation effects*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000528:radiation effects*; D003374:Coumarins; D006027:Glycosides; D008027:Light; D010777:Photochemistry
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003374:Coumarins; D006027:Glycosides; C031782:gilvocarcin M; C031781:gilvocarcin V