title: Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients.
abstract: The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopenem demonstrated consistent activity against Escherichia coli [minimum inhibitory concentration (MIC90) = 1.0 microgram/ml)] Klebsiella pneumoniae (MIC90 = 2.0 micrograms/ml), Salmonella enteriditis and Shigella spp. (MIC90 = 1.0 microgram/ml), and beta-lactamase-positive or -negative Haemophilus influenzae (MIC90 = 1.0 microgram/ml) and Moraella catarrhalis (MIC90 = 1.0 microgram/ml). Furopenem was also active against a number of the Gram-positive organisms tested including methicillin-susceptible Staphylococcus aureus and penicillin-susceptible Streptococcus pneumoniae. These results suggest a potential application for this agent in the treatment of children as outpatients.
authors.affiliation: Department of Laboratories, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Mortensen
authors.forename: J H
authors.initials: JH
authors.lastname: Egleton
mesh_terms: D001420:Bacteria, Aerobic / Q000187:drug effects* / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002675:Child, Preschool; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*
chemical_list: D015780:Carbapenems; D002511:Cephalosporins; D010406:Penicillins; C060114:SUN 5555