The week in phylogeny and ontogeny: opportunities for oncology.
Like circadian systems, multiseptans are apparently frequent if not ubiquitous chronome components. There is growing evidence from both basic and applied viewpoints that built-in circaseptans play a role complementary to the circadian system as does the circasemiseptan component. We have here compared circaseptans and circasemiseptans, by reference to their corresponding circadians, in humans (at early stages of development or as adults in society vs. isolation in caves) and across species (notably in organisms identified as early inhabitants of the earth), in growth and regeneration, and in tumor markers, presumably reflecting the host carrying a malignant growth, in pre-disease and in overt illness. Intermodulations within the components of chronomes of a given set of variables, and among components of chronomes of different variables, the feedsidewards, are the basic characteristics of life. Many frequencies lower than those here considered, including the biologic year and a component corresponding to the length of the solar cycle have been opportunistically studied. Because of practicality only, the relation of circasemiseptan and circaseptan chronome components to circadian components was here explored as a hint that much information lies in the relations among rhythms with different frequencies, for oncologists in particular.
Halberg
F
F
Chronobiology Laboratory, University of Minnesota, Minneapolis 55455, USA.
D000328:Adult; D005075:Biological Evolution; D014408:Biomarkers, Tumor / Q000502:physiology; D002909:Chronobiology Phenomena / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010802:Phylogeny; D013997:Time Factors
D014408:Biomarkers, Tumor