Lipid peroxidation in cord blood at birth.
OBJECTIVE
The purpose of this study was to determine oxygen free radical activity in the neonate at birth and relate it to umbilical cord blood acid-base status.


METHODS
A series of 110 singleton deliveries had determination of two lipoperoxides in umbilical cord blood: malondialdehyde and organic hydroperoxide. Umbilical pH, PO2, PCO2, bicarbonate, and base excess were also measured.


RESULTS
There was a significant association between lipoperoxides and cord blood pH and base excess. A significant difference existed in the levels of umbilical artery lipoperoxides between nonacidemic and acidemic fetus, as defined by an umbilical arterial pH < 7.20.


CONCLUSIONS
There is a positive association between lipoperoxide production and acid-base balance at delivery.
Wang
W
W
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Pang
C C
CC
Rogers
M S
MS
Chang
A M
AM
D000136:Acid-Base Equilibrium; D000293:Adolescent; D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D010100:Oxygen / Q000097:blood; D011247:Pregnancy
D002245:Carbon Dioxide; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D010100:Oxygen