title: Thermic effect of food in hypothyroid rats.
abstract: The regulatory and obligatory components of cephalic and gastrointestinal phases of the thermic effect of food (TEF) were measured in control and hypothyroid rats. A significant decrease (P < 0.05) in regulatory and obligatory components of cephalic and gastrointestinal TEF, after either a control or energy-dense meal, was found in hypothyroid rats compared with control rats. Our findings indicate that hypothyroidism is associated with a decreased thermogenic response to food which contributes to the reduced energy expenditure of hypothyroid rats. Our results also suggest that tri-iodothyronine is involved in the regulation of postprandial thermogenesis directly as well as through its influence on beta-adrenergic response and insulin release.
authors.affiliation: Department of General and Environmental Physiology, University of Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Iossa
authors.forename: L
authors.initials: L
authors.lastname: Lionetti
authors.forename: M P
authors.initials: MP
authors.lastname: Mollica
authors.forename: A
authors.initials: A
authors.lastname: Barletta
authors.forename: G
authors.initials: G
authors.lastname: Liverini
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D007037:Hypothyroidism / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood / Q000378:metabolism; D015430:Weight Gain
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine