New insights into the function of collagens from genetic analysis.
Recent studies utilizing transgenic approaches, in combination with mouse and human genetics, are leading to insights into the in vivo functions of fibrillar and non-fibrillar collagens. This information helps define the molecular causes of inherited disorders of connective tissues and provides answers to fundamental questions of tissue and organ morphogenesis.
Olsen
B R
BR
Department of Cell Biology, Harvard Medical School, Boston, MA 02115-6092, USA.
D000818:Animals; D030801:Animals, Genetically Modified; D003094:Collagen / Q000235:genetics / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation
D003094:Collagen