title: A right ventricular hemopump restores right ventricular function with pulmonary artery banding.
abstract: We investigated the ability of the Hemopump to support the right ventricle during acute, partial, pulmonary artery obstruction. In 6 pigs, a 14 Fr size Hemopump was placed through the pulmonary artery into the right ventricle. Control measurements were made. A band around the pulmonary artery proximal to the outflow port of the Hemopump was tightened, and measurements were repeated with the Hemopump at minimum and then maximum speed. With banding, right ventricular stroke volume and output decreased (43 [SD, 7] to 28 [SD, 8] ml, p < 0.001; 4.9 [SD, 0.8] to 3.7 [SD, 1.0] L/min, p < 0.01 respectively), but they were restored with the Hemopump (38 [SD, 5] ml and 4.5 [SD, 0.6] L/min; both p = NS vs control). Increases in right ventricular peak systolic (28 [SD, 10] to 42 [SD, 17] mm Hg; p < 0.01) and end-diastolic pressure (2 [SD, 1] to 12 [SD, 6] mm Hg; p < 0.02) were reversed by the Hemopump (29 [SD, 8] and 4 [SD, 2] mm Hg; both p = NS vs control). Right ventricular pressure rate product almost doubled with banding (3,199 [SD, 1,252] to 5,962 [SD, 2,796] mm Hg; p < 0.01), but it decreased with the Hemopump (3,368 [SD, 767] mm Hg; p = NS vs control). With acute partial pulmonary artery banding, a right ventricular Hemopump restores output from and offloads the right ventricle.
authors.affiliation: Centre de Recherches Chirurgicales Henri Mondor, Association Claude Bernard, Créteil, France.
authors.forename: G J
authors.initials: GJ
authors.lastname: Cooper
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Miyama
authors.forename: P
authors.initials: P
authors.lastname: Deleuze
authors.forename: D Y
authors.initials: DY
authors.lastname: Loisance
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003250:Constriction; D006353:Heart-Assist Devices / Q000592:standards*; D011651:Pulmonary Artery / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume / Q000502:physiology; D013552:Swine; D016278:Ventricular Function, Right