[Protein-carbohydrate recognition. Foundation and medical application with illustrations of tumor lectin studies].
Protein-carbohydrate interactions are involved in multifarious physiological processes. Together with antibodies and enzymes, lectins constitute the family of carbohydrate-binding proteins. The current research activities of tumor lectinology comprise the design of custom-made carrier-immobilized carbohydrate ligands (neoglycoconjugates), their application for the detection of specific binding sites and the evaluation of potential therapeutical approaches by blocking access or by directing drug conjugates to cell surface lectins, correlation of their expression to clinical parameters such as prognosis and their biochemical characterization. Thereby, mammalian lectins are made available to serve as tools. These experimental approaches are evaluated as regards their potential for improving cancer diagnosis and therapy.
Gabius
H J
HJ
Institut für Physiologische Chemie, Tierärztliche Fakultät der Universität, München.
Kayser
K
K
Gabius
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002236:Carbohydrate Conformation; D050260:Carbohydrate Metabolism; D002240:Carbohydrate Sequence; D004337:Drug Carriers; D006001:Glycoconjugates / Q000502:physiology*; D006801:Humans; D037102:Lectins / Q000502:physiology*; D008322:Mammals; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D011506:Proteins / Q000378:metabolism*
D000970:Antineoplastic Agents; D004337:Drug Carriers; D006001:Glycoconjugates; D037102:Lectins; D011506:Proteins
Protein-Zucker-Erkennung. Grundlagen und medizinische Anwendung am Beispiel der Tumorlektinologie.