title: A live attenuated vaccine for the control of avian coccidiosis: trials in broiler breeders and replacement layer flocks in the United Kingdom.
abstract: Losses caused by coccidiosis are a significant problem in the rearing of breeder and layer flocks. A live vaccine has been developed that contains attenuated lines of the seven species of Eimeria that infect the chicken. The attenuated lines were derived from virulent strains by selection for earlier development in chickens. In 11 field trials, the performance of vaccinated chicks was compared with that of matched controls receiving conventional drug prophylaxis. The vaccine was given in the drinking water to 116,600 young chickens and provided excellent control of coccidiosis. The occurrence of coccidial oocysts in the litter, coccidial lesions post mortem and overt coccidiosis was markedly lower in the vaccinated birds than in the controls.
authors.affiliation: Institute for Animal Health, Compton Laboratory, Newbury.
authors.forename: M W
authors.initials: MW
authors.lastname: Shirley
authors.forename: A C
authors.initials: AC
authors.lastname: Bushell
authors.forename: J E
authors.initials: JE
authors.lastname: Bushell
authors.forename: V
authors.initials: V
authors.lastname: McDonald
authors.forename: B
authors.initials: B
authors.lastname: Roberts
mesh_terms: D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000453:epidemiology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D004539:Eimeria / Q000276:immunology*; D005260:Female; D010270:Parasite Egg Count / Q000662:veterinary; D011201:Poultry Diseases / Q000453:epidemiology / Q000469:parasitology / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000008:administration & dosage*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated