title: [Biochemical-histological study of the effects of lithium on various organs of vizcacha (Lagostomus maximus maximus)].
abstract: Considering that the vizcacha (Lagostomus maximus maximus) is a very Lithium sensitive rodent, we planned a biochemical-histological study injecting IP doses of 1 mEq/kg/day LiCl during one month to adult vizcachas, and they were divided into three lots: Lot I the optical microscopy revealed evident renal, gonadal, hyphophyseal and adrenal damages; the biochemical analysis showed that Li significantly decreased the female serum LH levels while testosterone and estradiol levels were not affected. The male Li serum values resulted to be significantly higher than those of female animals. The damage was greater in male specimens. Lott II: the tissue recovery from the damage observed in Lot I was the following: total in hyphophysis, partial in testis, the same in kidney and was enhanced in adrenal and ovary. The Li renal clearance was determined in Lot III verifying no changes in both sexs. According to our results, Li (1 mEq/kg/day during one month) produce modifications in different tissues probably the gonadal damage may be consequence of a direct Li effect and not for a hyphophysis alteration, since in male vizcacha the LH serum level was not changed. In regard to the selective effect in the suprarenal glomerulus structure, this Li effect is produced via hyphophysis. In conclusion, the selective effect of Li on adrenal and gonada organs of this rodent is a contribution in order to warm about the possible reproduction of such effects in human beings.
authors.affiliation: Cátedra De Farmacología, Universidad Nacional De San Luis.
authors.forename: S
authors.initials: S
authors.lastname: García Aseff
authors.forename: L B
authors.initials: LB
authors.lastname: Fuentes
authors.forename: A O
authors.initials: AO
authors.lastname: Maria
authors.forename: J A
authors.initials: JA
authors.lastname: Guzmán
authors.forename: F
authors.initials: F
authors.lastname: Mohamed
authors.forename: E
authors.initials: E
authors.lastname: Muñoz
authors.forename: A
authors.initials: A
authors.lastname: Ribes
authors.forename: S
authors.initials: S
authors.lastname: Domínguez
authors.forename: L
authors.initials: L
authors.lastname: Scardapane
authors.forename: O
authors.initials: O
authors.lastname: Villegas
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D005260:Female; D006066:Gonads / Q000187:drug effects* / Q000473:pathology; D007672:Kidney Cortex / Q000473:pathology; D018021:Lithium Chloride / Q000097:blood / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D012377:Rodentia / Q000097:blood*; D012737:Sex Factors
chemical_list: D007986:Luteinizing Hormone; D018021:Lithium Chloride
vernacular_title: Estudio bioquímico-histológico de los efectos de litio en algunos órganos de vizcacha (Lagostomus maximus maximus).