title: The sedative and analgesic effects of detomidine (Domosedan) in donkeys.
abstract: Detomidine (Domosedan) was administered to four groups of donkeys, using four different dosages (5, 10, 20 and 40 micrograms/kg bwt) intravenously. The drug provided adequate sedation at dosages of 5 and 10 micrograms/kg bwt. Sedation deepened only slightly by increasing the dose. Analgesia was considered good with a dose of 20 micrograms/kg, and 40 micrograms/kg provided a deep analgesia associated with a longer duration. No significant changes had been observed in haematocrit (PCV), haemoglobin content (Hb %), total red and white cell counts and differential leucocytic counts. It was concluded that detomidine is a valuable sedative and analgesic drug to be used in donkeys without any serious implications.
authors.affiliation: Department of Veterinary Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Egypt.
authors.forename: M B
authors.initials: MB
authors.lastname: Mostafa
authors.forename: K A
authors.initials: KA
authors.lastname: Farag
authors.forename: E
authors.initials: E
authors.lastname: Zomor
authors.forename: M M
authors.initials: MM
authors.lastname: Bashandy
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D018397:Equidae / Q000097:blood / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine