Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice.
A slight increase in mean corpuscular hemoglobin (MCH) has been reported in erythrocytes from human fragile X patients. As it is difficult to perform case-controlled studies in patients with fragile X syndrome, we studied MCH in erythrocytes from transgenic mice with an Fmr1 knockout. None of the knockout mice showed increased MCH levels when compared with normal littermates. We conclude that it is unlikely that the FMR1 gene product has an effect on MCH.
Reyniers
E
E
Department of Medical Genetics, University of Antwerp, Belgium.
Van Bockstaele
D R
DR
De Boulle
K
K
Kooy
R F
RF
Bakker
C E
CE
Oostra
B A
BA
Willems
P J
PJ
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000097:blood* / Q000235:genetics; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D012016:Reference Values
D051860:Fragile X Messenger Ribonucleoprotein 1; D006454:Hemoglobins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human; C497684:Fmr1 protein, mouse