In vivo metabolism of benzo(a)pyrene in a lower vertebrate, the newt Pleurodeles walt.
The capacity of the newt to metabolize benzo(a)pyrene in vivo was investigated qualitatively and quantitatively: metabolism was found to be rapid. Treatment of bile with beta-glucuronidase and aryl-sulfatase released high proportions of diols and quinones. 3-Methylcholanthrene treatment shortened the elimination half-life of benzo(a)pyrene which was about three times shorter than the half-life found for non-3-methylcholanthrene-pretreated animals. Thus, a greater proportion of benzo(a)pyrene was converted into water-soluble products.
Marty
J
J
CNRS, Centre de Biologie du Développement, UMR 9925, Université Paul Sabatier, Toulouse, France.
Michel
X R
XR
Narbonne
J F
JF
Ferrier
V
V
D000818:Animals; D001564:Benzo(a)pyrene / Q000493:pharmacokinetics*; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004785:Environmental Pollutants / Q000493:pharmacokinetics*; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D008748:Methylcholanthrene / Q000494:pharmacology; D010999:Pleurodeles / Q000378:metabolism*; D011874:Radiometry
D004785:Environmental Pollutants; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene