title: Chlorogenic acid as a natural scavenger for hypochlorous acid.
abstract: The effect of chlorogenic acid (CGA) on the killing of Escherichia coli by hypochlorous acid (HOCI) was examined. CGA prevented E. coli from bactericidal action of HOCI in a concentration-dependent manner. HOCI reacted rapidly with CGA. By comparison with the one- and two-electron oxidation products produced by peroxidase and phenolase reactions, respectively, the main product was identified as o-quinone of CGA via the formation of o-semiquinone of CGA as an intermediate The quinone form of CGA reacted further with HOCI to yield unstable product(s).
authors.affiliation: Department of Bacteriology, Faculty of Medicine, Tottori University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kono
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Kodama
authors.forename: A
authors.initials: A
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Sawa
mesh_terms: D001770:Blood Bactericidal Activity; D002726:Chlorogenic Acid / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects*; D005609:Free Radicals; D006997:Hypochlorous Acid / Q000737:chemistry*; D010084:Oxidation-Reduction; D011809:Quinones / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D005609:Free Radicals; D011809:Quinones; D002726:Chlorogenic Acid; D006997:Hypochlorous Acid