title: Compression of lactose, glucose and mannitol granules.
abstract: The effect of the amount of granulation liquid, compression speed and maximum compression force on then compressibility and compactibility of lactose, glucose and mannitol granules was studied. The porosity based on the geometrical shape and the uniformity of weight of tablets was also studied. Lactose and mannitol granules showed a greater compressibility than glucose granules. Mannitol granules produced the hardest tablets and lactose and glucose the weakest. The change in the amount of granulation liquid caused changes both in the granule porosity and in the amount of binder; this was attributed to differences in tablet strength. All parameters studied were relatively insensitive to changing speeds of compression in the range used, except for the breaking force of mannitol tablets, which was greatest with the lowest speed of compression. All granule masses showed a relatively good continuous flow suitable for table production. Tablets compressed from lactose granules had the best uniformity of weight of the tablets studied.
authors.affiliation: University of Helsinki, Department of Pharmacy, Finland.
authors.forename: A M
authors.initials: AM
authors.lastname: Juppo
authors.forename: L
authors.initials: L
authors.lastname: Kervinen
authors.forename: J
authors.initials: J
authors.lastname: Yliruusi
authors.forename: E
authors.initials: E
authors.lastname: Kristoffersson
mesh_terms: D004304:Dosage Forms; D004339:Drug Compounding; D005947:Glucose / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D008353:Mannitol / Q000737:chemistry*; D013607:Tablets
chemical_list: D004304:Dosage Forms; D013607:Tablets; D008353:Mannitol; D005947:Glucose; D007785:Lactose