title: Principles of protein-protein interactions.
abstract: This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College, London, England.
authors.forename: S
authors.initials: S
authors.lastname: Jones
authors.forename: J M
authors.initials: JM
authors.lastname: Thornton
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000737:chemistry; D018360:Crystallography, X-Ray; D006801:Humans; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000936:Antigen-Antibody Complex; D046911:Macromolecular Substances; D011506:Proteins