title: Neuroendocrine tumors of the liver and pancreas associated with elevated serum prostatic acid phosphatase.
abstract: A 58-year-old man was revealed to have multiple liver tumors with elevated prostatic acid phosphatase (PAP) during a medical examination. The tumors were of neuroendocrine nature, but no abnormal findings were obtained in other organs in which neuroendocrine tumors develop frequently. Repeated transarterial embolization was partially effective. However, the tumors became resistant to the therapy three years later, continued growing and ruptured. Autopsy disclosed neuroendocrine tumors in the pancreas, which were immunohistologically positive for PAP. Neuroendocrine tumors of the pancreas and liver producing PAP are rare; this case is reported with a review of literature.
authors.affiliation: First Department of Medicine, Faculty of Medicine, University of Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: N
authors.initials: N
authors.lastname: Motoi
authors.forename: A
authors.initials: A
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Motoi
authors.forename: T
authors.initials: T
authors.lastname: Oka
authors.forename: R
authors.initials: R
authors.lastname: Machinami
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000201:enzymology*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D011467:Prostate / Q000201:enzymology*
chemical_list: D000135:Acid Phosphatase