title: [Fasciolinip-1: experimental fasciolicidal activity in sheep].
abstract: The aim of the present study was to evaluate the flukicide efficacy of the 2-amino-5(6)-chloro-1-methoxycarbonylbenzimidazole (II), named Fasciolinip-1, against eight and twelve-week old flukes in sheep. In a first experiment 35 young sheep were infected each with 300 metacercariae of Fasciola hepatica. Eight weeks postinfection five groups of seven animals each were treated as follows: Groups 1, 2 and 3 were given 2.5, 5 and 10 mg/kg of Fasciolinip-1. Groups 4 and 5 remained as non-treated and vehicle controls, respectively. In a second study, 32 sheep were infected each with 150 metacercariae. Twelve weeks postinfection, the animals were divided into 4 groups of 8 sheep each. Groups 1, 2 and 3 were treated orally with 5, 10 and 15 mg/kg of Fasciolinip-1, respectively. Group 4 remained as non-treated control. Fifteen days after treatment, all sheep from both experiments were killed to collect the flukes present in liver. Results indicated efficacies of 19.1%, 49.6% and 65.2% for groups 1, 2 and 3 of the first study and 48.3%, 64.8 and 90.6% for sheep of the second experiment, respectively. It was concluded that Fasciolinip-1 removed 8-week old flukes in limited numbers and 12-week old flukes in 90.6% when used at 15 mg/kg body weight.
authors.affiliation: Proyecto Fasciolasis, CENID-Parasitología/INIFAP, Cuernavaca-Cuautla, Estado de Morelos, Mexico.
authors.forename: F
authors.initials: F
authors.lastname: Ibarra-Velarde
authors.forename: Y
authors.initials: Y
authors.lastname: Vera-Montenegro
authors.forename: S
authors.initials: S
authors.lastname: Olazarán-Jenkins
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Campos
authors.forename: R
authors.initials: R
authors.lastname: Castillo-Bocanegra
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D001652:Bile Ducts / Q000469:parasitology; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D005210:Fasciola hepatica / Q000187:drug effects* / Q000302:isolation & purification; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D010270:Parasite Egg Count; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome
chemical_list: C097677:2-amino-5(6)-chloro-1-methoxycarbonylbenzimidazole; D000871:Anthelmintics; D001562:Benzimidazoles
vernacular_title: Fasciolinip-1: eficacia fasciolicida experimental en ovinos.