Successful methylphenidate treatment of apathy after subcortical infarcts.
A patient with prominent apathy secondary to multiple subcortical infarcts was treated successfully with methylphenidate. SPECT and reaction time testing showed selective improvement of frontal system function, consistent with a recent model of frontal-subcortical circuits and behavior.
Watanabe
M D
MD
Department of Pharmacy Practice, University of Illinois-Chicago 60612, USA.
Martin
E M
EM
DeLeon
O A
OA
Gaviria
M
M
Pavel
D G
DG
Trepashko
D W
DW
D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000523:psychology; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use*; D009042:Motivation; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000523:psychology; D012039:Regional Blood Flow / Q000187:drug effects; D012919:Social Behavior; D015899:Tomography, Emission-Computed, Single-Photon
D000697:Central Nervous System Stimulants; D008774:Methylphenidate