Effects of S-allyl cysteine sulfoxide isolated from Allium sativum Linn and gugulipid on some enzymes and fecal excretions of bile acids and sterols in cholesterol fed rats.
S-allyl cysteine sulfoxide, isolated from garlic, A. sativum, is more or less as active as gugulipid in controlling hypercholestermia, obesity and derangement of enzyme activities in cholesterol diet fed rats. The beneficial effects of the drugs are partly due to their inhibitory effects on transaminases, alkaline phosphatase, lipogenic enzymes and HMG CoA reductase and partly due to their stimulatory effects on plasma lecithin-cholesterol acyl transferase lipolytic enzymes and fecal excretion of sterols and bile acids.
Sheela
C G
CG
Department of Bio-Chemistry, University of Kerala, Thiruvananthapuram, India.
Augusti
K T
KT
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D029744:Commiphora; D003545:Cysteine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D004798:Enzymes / Q000097:blood; D005243:Feces / Q000737:chemistry; D005737:Garlic / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D053149:Plant Gums; D010946:Plants, Medicinal; D051381:Rats; D013261:Sterols / Q000378:metabolism*
D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D004798:Enzymes; D010936:Plant Extracts; D053149:Plant Gums; D013261:Sterols; C018562:guggulu extract; C006453:alliin; D003545:Cysteine