[Prevention of galactose-induced cataractogenesis in rats by salvianolic acid A].
Salvianolic acid A has been demonstrated to have efficient antioxidative and free radical scavenging effects. In the present experiments, the preventive effects of salvianolic acid A on galactose-induced cataract in rats were investigated. Dropping 0.05% salvianolic acid A in the eyes (two times a day) was found to delay the development of cataract. The contents of MDA and H2O2 in the cataract lens were decreased in salvianolic acid A treated rats. The protein and non-protein thiols in the cataract lens of the salvianolic acid A treated rats were higher than those of control rats. In in vitro experiments salvianolic acid A was shown to inhibit aldose reductase activity. These results indicate that salvianolic acid A can prevent galactose-induced cataract by antioxidation and inhibition of aldose reductase.
Du
G H
GH
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Qiu
Y
Y
Tian
Y E
YE
Zhang
J T
JT
D000449:Aldehyde Reductase / Q000378:metabolism; D000818:Animals; D002109:Caffeic Acids / Q000302:isolation & purification / Q000627:therapeutic use*; D002386:Cataract / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005690:Galactose; D006861:Hydrogen Peroxide / Q000378:metabolism; D007773:Lactates / Q000302:isolation & purification / Q000627:therapeutic use*; D007908:Lens, Crystalline / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D007773:Lactates; D008315:Malondialdehyde; C066201:salvianolic acid A; D006861:Hydrogen Peroxide; D000449:Aldehyde Reductase; D005690:Galactose