[Characterization of lorazepam and oxazepam by the thermal behavior of their degradation product].
Lorazepam and oxazepam are benzodiazepine which differ by the presence, or not, of chlorine atom on the phenyl ring. These molecules are able of chemical and thermal degradation with water intramolecular elimination between hydroxy and amine functional group and formation of carboxaldehyde quinazoline. These substances characterise lorazepam and oxazepam by their thermal behaviour and melting temperature by heating and cooling cycles.
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Faculté de Pharmacie, Laboratoire de Chimie Générale et Minérale, Montpellier.
D014151:Anti-Anxiety Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D006358:Hot Temperature; D008140:Lorazepam / Q000737:chemistry*; D010076:Oxazepam / Q000737:chemistry*; D013818:Thermogravimetry
D014151:Anti-Anxiety Agents; D010076:Oxazepam; D008140:Lorazepam
Caractérisation du lorazépam et de l'oxazépam par le comportement thermique de leur produit de dégradation.