title: Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis.
abstract: The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.
authors.affiliation: Hemostasis and Thrombosis Research Center, University Hospital Leiden, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Bertina
authors.forename: P H
authors.initials: PH
authors.lastname: Reitsma
authors.forename: F R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: J P
authors.initials: JP
authors.lastname: Vandenbroucke
mesh_terms: D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D018572:Disease-Free Survival; D004777:Environment; D004789:Enzyme Activation; D005165:Factor V / Q000235:genetics*; D005166:Factor V Deficiency / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D015995:Prevalence; D011486:Protein C / Q000378:metabolism*; D012307:Risk Factors; D013924:Thrombophlebitis / Q000453:epidemiology / Q000209:etiology*
chemical_list: D003278:Contraceptives, Oral, Hormonal; D011486:Protein C; C095381:factor V Leiden; D005165:Factor V