Prognostic relevance of Ki-67 antigen and c-myc oncoprotein in malignant fibrous histocytoma.
47 cases of malignant fibrous histiocytoma were stained immunohistochemically for the presence of Ki-67 antigen and c-myc oncoprotein. Percentage of Ki-67 and c-myc positive cells correlated with each other and with grade of tumour, mitotic index, cellularity and survival time of patients, but not with the extent of necrosis. Differences of mean values of Ki-67 index between grade I and grade II tumours as well as between grade II and grade III tumours were highly statistically significant. All 3 parameters connected with c-myc expression (index, intensity and score) differed significantly between grade I and grade II tumours but not between grade II and grade III MFH. The possible differential role of Ki-67 antigen and c-myc oncoprotein for improvement of grading is discussed.
Brinck
U
U
Department of Pathology Georg August University Göttingen, Germany.
Stachura
J
J
Kellner
S
S
Schauer
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis*
D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc