8-Oxo-2'-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy.
We analyzed the level of 8-oxo-2'-deoxyguanosine in lymphocytes DNA of cancer patients undergoing radiotherapy. The results of this work indicate that exposure of cancer patients to therapeutic doses of ionizing radiation causes significant increase of the amount of 8-oxo-dG in DNA isolated from their lymphocytes.
Bialkowski
K
K
Department of Clinical Biochemistry, University School of Medical Sciences, Bydgoszcz, Poland. karolb/aci.amb.bydgoszcz.pl.
Kowara
R
R
Windorbska
W
W
Olinski
R
R
D000080242:8-Hydroxy-2'-Deoxyguanosine; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000097:blood* / Q000532:radiotherapy*; D004273:DNA, Neoplasm / Q000097:blood* / Q000528:radiation effects*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D006801:Humans; D007206:Individuality; D008175:Lung Neoplasms / Q000097:blood* / Q000532:radiotherapy*; D008214:Lymphocytes / Q000378:metabolism* / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D013056:Spectrophotometry, Ultraviolet
D004273:DNA, Neoplasm; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine