title: Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults.
abstract: We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 micrograms i.m.) (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached > or = 100 mIU/mL at a similar rate, but a higher seroprotection rate at > or = 500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti-hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.
authors.affiliation: Department of Medicine, University of Kentucky, Lexington 40536-0084, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Marsano
authors.forename: R N
authors.initials: RN
authors.lastname: Greenberg
authors.forename: R B
authors.initials: RB
authors.lastname: Kirkpatrick
authors.forename: R K
authors.initials: RK
authors.lastname: Zetterman
authors.forename: A
authors.initials: A
authors.lastname: Christiansen
authors.forename: D J
authors.initials: DJ
authors.lastname: Smith
authors.forename: M D
authors.initials: MD
authors.lastname: DeMedina
authors.forename: E R
authors.initials: ER
authors.lastname: Schiff
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D016037:Single-Blind Method; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic