The effects of hormone replacement therapy on uterine fibroids in postmenopausal women.
OBJECTIVE
To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids.


METHODS
Randomized clinical study.


METHODS
The Menopause Center of a public hospital.


METHODS
Postmenopausal women with small asymptomatic uterine fibroids were selected.


METHODS
One group was treated with 50 micrograms transdermal E2 plus 5 mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625 mg conjugated equine estrogen plus 2.5 mg MPA continuously.


METHODS
The size of the uterine fibroids was measured before and after the first year of HRT.


RESULTS
At the end of the first year on HRT, the size of the uterine fibroids was re-evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.


CONCLUSIONS
Hormone replacement therapy with 50 micrograms transdermal E2 plus 5 mg MPA increases the size of the uterine fibroids.
Sener
A B
AB
Dr. Zekai Tahir Burak Women's Hospital, Menopause Center, Ankara, Turkey.
Seçkin
N C
NC
Ozmen
S
S
Gökmen
O
O
Doğu
N
N
Ekici
E
E
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D017698:Postmenopause; D014594:Uterine Neoplasms / Q000188:drug therapy*
D018931:Antineoplastic Agents, Hormonal; D004958:Estradiol; D017258:Medroxyprogesterone Acetate