Ionophoretic properties of the non-sulfonylurea hypoglycemic agents A-4166 and KAD-1229.
The non-sulphonylurea hypoglycaemic agents A-4166 and KAD-1229 were both found to cause 45Ca or 22Na translocation from an aqueous medium into an organic immiscible phase. This ionophoretic effect was more marked with A-4166 than KAD-1229, in mirror image of their insulinotropic potency. Such a dissociated behaviour argues against the view that the ionophoretic properties of these agents represent a major determinant of their insulinotropic action.
Bakkali-Nadi
A
A
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Malaisse-Lagae
F
F
Malaisse
W J
WJ
D002118:Calcium / Q000737:chemistry / Q000494:pharmacology; D002132:Calcium Radioisotopes; D003510:Cyclohexanes / Q000737:chemistry* / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D007476:Ionophores / Q000737:chemistry* / Q000494:pharmacology*; D054833:Isoindoles; D007700:Kinetics; D008567:Membranes, Artificial; D000077715:Nateglinide; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D012965:Sodium Chloride / Q000737:chemistry / Q000494:pharmacology
D002132:Calcium Radioisotopes; D003510:Cyclohexanes; D007004:Hypoglycemic Agents; D007211:Indoles; D007476:Ionophores; D054833:Isoindoles; D008567:Membranes, Artificial; D000077715:Nateglinide; D012965:Sodium Chloride; D010649:Phenylalanine; C087255:mitiglinide; D002118:Calcium