Pharmacology of receptors for calcitonin gene-related peptide and amylin.
Calcitonin gene-related peptide (CGRP), a widespread neuropeptide with multiple actions, has substantial homology with amylin, a peptide implicated in insulin-resistant diabetes, and adrenomedullin, a recently discovered potent vasodilator. There is controversy over the existence of CGRP receptor subtypes, and whether independent receptors exist for amylin and adrenomedullin. In this article, the current status of CGRP receptor classification is reviewed by David Poyner, taking particular account of species differences, and evidence is presented supporting the existence of multiple receptors for CGRP, as well as independent binding sites for amylin.
Poyner
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Department of Pharmaceutical and Biological Sciences, Aston University, Aston Triangle, Birmingham.
D000595:Amino Acid Sequence; D000682:Amyloid / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism / Q000494:pharmacology*; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D008297:Male; D008969:Molecular Sequence Data; D011869:Radioligand Assay; D051381:Rats; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000737:chemistry / Q000145:classification* / Q000187:drug effects / Q000378:metabolism; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000145:classification* / Q000187:drug effects / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014649:Vas Deferens / Q000187:drug effects / Q000378:metabolism
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D018015:Receptors, Calcitonin Gene-Related Peptide; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide; D015740:Calcitonin Gene-Related Peptide