Differentiation of extramedullary acute promyelocytic leukemia by all-trans-retinoic acid.
The effect of all-trans-retinoic acid (ATRA) on extramedullary acute promyelocytic leukemia (APL) has not been fully delineated. We report an unusual case of APL in which a patient relapsed in the skin and central nervous system. Cytodifferentiation of leukemic cells from these extramedullary sites was demonstrated following treatment with ATRA.
Lederman
C A
CA
Division of Oncology/Hematology, New York Medical College, Valhalla, New York 10595, USA.
Weisberger
J
J
Seiter
K
K
Feldman
E J
EJ
D001853:Bone Marrow / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D002490:Central Nervous System / Q000473:pathology; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D017254:Leukemic Infiltration; D007964:Leukocytosis / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use*
D014212:Tretinoin