title: Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (fa/fa) rats.
abstract: Expression of the obese (ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the ob gene expression during the development of obesity, we examined the ob gene expression in genetically obese-hyperglycemic Wistar fatty (fa/fa) rats at several stages of obesity. The ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the ob gene expression.
authors.affiliation: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Masuzaki
authors.forename: K
authors.initials: K
authors.lastname: Hosoda
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Shigemoto
authors.forename: N
authors.initials: N
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: N
authors.initials: N
authors.lastname: Tamura
authors.forename: S
authors.initials: S
authors.lastname: Nishi
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimasa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamori
authors.forename: K
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000367:Age Factors; D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D015870:Gene Expression; D006943:Hyperglycemia / Q000150:complications / Q000235:genetics; D020738:Leptin; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D020738:Leptin; D011506:Proteins; D012333:RNA, Messenger; D008071:Lipoprotein Lipase