title: Bromide toxicosis secondary to renal insufficiency in an epileptic dog.
abstract: Bromide toxicosis was diagnosed in an 8-year-old Labrador Retriever that had been treated for epilepsy with potassium bromide, at a dosage of 29 mg/kg of body weight/d. Clinical signs included hind limb weakness, ataxia, and disorientation. Renal insufficiency, diagnosed by determination of endogenous creatinine clearance, was believed to be responsible for the development of bromide toxicosis in this dog. Diuresis with physiologic saline solution and discontinuation of bromide and phenobarbital treatment resulted in rapid resolution of abnormal neurologic signs; however, serum bromide concentrations decreased dramatically during diuresis and seizures recurred. Although saline diuresis has been recommended for the treatment of bromide intoxication in human beings, more conservative measures, such as discontinuation of bromide and short-term fluid administration, may be more appropriate for epileptic dogs.
authors.affiliation: Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Nichols
authors.forename: L A
authors.initials: LA
authors.lastname: Trepanier
authors.forename: K
authors.initials: K
authors.lastname: Linn
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D001965:Bromides / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D003404:Creatinine / Q000378:metabolism; D004231:Diuresis; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006207:Half-Life; D008657:Metabolic Clearance Rate; D010634:Phenobarbital / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy / Q000662:veterinary; D017680:Potassium Compounds / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000150:complications / Q000662:veterinary*; D012965:Sodium Chloride / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; D012965:Sodium Chloride; D003404:Creatinine; C039004:potassium bromide; D010634:Phenobarbital