title: [The clinical efficacy of the first Russian angiotensin-converting enzyme inhibitor methiopril in patients with heart failure].
abstract: Changes in central hemodynamics as recorded by tetrapolar rheography were investigated in 90 coronary heart disease (CHD) patients with circulatory insufficiency (CI) receiving methiopril. Relevant clinical response was registered in 94%, hemodynamic in 83% of patients. Those with CI stage IIA and IIB benefited more. Arterial pressure went down significantly only in CHD patients with arterial hypertension. Tachycardia patients showed a reduction in pulse rate absent in bradycardia. Cardiac output increased at the expense of low afterload. Efficient doses averaged 300 mg/day.
authors.forename: M G
authors.initials: MG
authors.lastname: Glezer
authors.forename: L L
authors.initials: LL
authors.lastname: Orlova
authors.forename: D Kh
authors.initials: DKh
authors.lastname: Titova
authors.forename: G Ia
authors.initials: GIa
authors.lastname: Shvarts
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology; D013607:Tablets; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013607:Tablets
vernacular_title: Klinicheskaia éffektivnost' pervogo otechestvennogo ingibitora angiotenzinprevrashchaiushchego fermenta metioprila u bol'nykh s serdechnoĭ nedostatochnost'iu.