[Lichen planus and hepatitis C virus. Apropos of 5 new cases].
Lichen planus is an immunologically mediated skin or mucous disease, which has recently been described in some patients with hepatitis C virus-related liver disease. We report 5 new cases of the association of hepatitis C with lichen planus, to be added to the 15 cases published in the literature. The sex ratio (female/male) was of 1.2. Lichen planus occurred more frequently in chronic active hepatitis (2/3 of cases) than in cirrhosis (1/3 of cases). Lichen planus manifestations were only mucous (30%), only cutaneous (40%) or both (30%). Mucous lesions were mainly observed in patients with cirrhosis (3/4 of cases). The onset of skin and hepatic manifestations was variable, with liver disease as the most frequent revealing symptom (60%). The influence of interferon remains unclear. However, it seemed to trigger more than to relieve lichen planus.
Hyrailles
V
V
Service d'Hépato-Gastroentérologie, Hôpital Saint-Eloi, Montpellier.
Peyron
N
N
Blanc
P
P
Mark
Y
Y
Meunier
L
L
Meynadier
J
J
Larrey
D
D
Michel
H
H
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006521:Hepatitis, Chronic / Q000150:complications* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D008010:Lichen Planus / Q000188:drug therapy / Q000209:etiology*; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D016898:Interferon-alpha
Lichen plan et virus de l'hépatite C. A propos de 5 nouveaux cas.