title: Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer.
abstract: PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.
authors.affiliation: Department of Pathology, University of Rijeka, Croatia.
authors.forename: D
authors.initials: D
authors.lastname: Kovac
authors.forename: M
authors.initials: M
authors.lastname: Rubinic
authors.forename: M
authors.initials: M
authors.lastname: Krasevic
authors.forename: S
authors.initials: S
authors.lastname: Krizanac
authors.forename: M
authors.initials: M
authors.lastname: Petrovecki
authors.forename: D
authors.initials: D
authors.lastname: Stimac
authors.forename: M
authors.initials: M
authors.lastname: Melato
mesh_terms: D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D015996:Survival Rate
chemical_list: D018809:Proliferating Cell Nuclear Antigen