Retinoic acid induces changes in Xenopus embryo glycolipid pattern.
Retinoic acid (RA), known for its important role in cellular differentiation, may cause a modification of glycolipid distribution characterized by a shift from globoserie towards latto- and ganglio-series. In the present paper, we have investigated the modifications of the lipidic pattern after exogenous RA treatment of Xenopus embryos. We have noticed a decrease in neutral glycolipids with a parallel increase in gangliosides; the content of sulfatides does not seem to be modified. Beside the shift toward ganglio-serie, we have also observed a redistribution inside this class of lipids. In particular, following RA treatment, the relative distribution of GD1b and GT1b increases while that of GM3 decreases.
Rizzo
A M
AM
Istituto di Fisiologia Generale e Chimica Biologica, Università di Milano.
Gornati
R
R
Rossi
F
F
Bernardini
G
G
Berra
B
B
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000737:chemistry; D005260:Female; D005732:Gangliosides / Q000378:metabolism; D006017:Glycolipids / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D013433:Sulfoglycosphingolipids / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism; D014981:Xenopus / Q000196:embryology*
D005732:Gangliosides; D006017:Glycolipids; D010743:Phospholipids; D011506:Proteins; D013433:Sulfoglycosphingolipids; D014280:Triglycerides; D014212:Tretinoin; D004247:DNA; D002784:Cholesterol