title: The effect of Toremifene on the expression of some genes in human mononuclear cells.
abstract: Toremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells. After short-term, in vitro exposure to therapeutical levels, distinct changes in P-glycoprotein, steroid receptors, p53 and Bcl-2 expression take place. In view of the increasing use of antiestrogens in cancer therapy and prevention, there is obvious merit in long-term in vivo studies to be conducted.
authors.affiliation: Sunnybrook Health Science Centre, Department of Clinical Biochemistry, University of Toronto, Ontario, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Kellen
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects / Q000235:genetics; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D011505:Protein-Tyrosine Kinases / Q000187:drug effects / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000187:drug effects / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2; D011987:Receptors, Steroid / Q000187:drug effects / Q000235:genetics; D017312:Toremifene / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects / Q000235:genetics
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018931:Antineoplastic Agents, Hormonal; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011987:Receptors, Steroid; D016159:Tumor Suppressor Protein p53; D017312:Toremifene; D011505:Protein-Tyrosine Kinases