title: [Effect of obstetric factors on neonatal hypoxic-ischemic brain injuries].
abstract: OBJECTIVE
  To determine the effect of high risk obstetric factors on neonatal hypoxic-ischemic brain injuries. The obstetric factors were investigated, including maternal complications during pregnancy and labor, the mode of delivery.
  
  
  METHODS
  Intensive B-ultrasound brain monitoring in 211 newborns within the first 48 hours of life was carried out. The abnormalities were followed up by B-ultrasound. We assessed the extent of hypoxic-ischemic brain injuries with two kind of types, mild and severe. The mild type included 1-2 degree intracranial hemorrhage and the local hypoxic-ischemic encephalopathy. The severe type included 3-4 degree intracranial hemorrhage and extensive cerebral edema.
  
  
  RESULTS
  Thirty-nine cases (18.5%) were diagnosed intracranial hemorrhage and 22 cases (10.4%) were diagnosed hypoxic-ischemic encephalopathy (HIE) or cerebral edema. The total positive rate was 28.9%. Of the positive cases, 67.2% were mild brain injuries without clinical symptoms. Those cases need no medical treatment and recovered in a natural course. The rates of brain injuries in groups of pregnancy induced hypertension, fetal distress, neonatal asphyxia and premature newborns, were 46.1%, 48.9%, 66.7% and 71.4% respectively. It suggested that high risk obstetric factors were closely related to neonatal brain injuries. 15.9% of positive cases were from normal mothers without any obstetric complications. The brain injuries in those cases were mild.
  
  
  CONCLUSIONS
  The study showed that as a non-invasive procedure, B ultrasound brain examination is necessary for newborns with perinatal high risk factors of brain injuries. The study also suggested that perinatal care and systematic fetal monitoring were key-points for reduction of neonatal brain injuries.
authors.affiliation: First Teaching Hospital, Beijing Medical University.
authors.forename: L
authors.initials: L
authors.lastname: Zhu
authors.forename: C
authors.initials: C
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications; D001929:Brain Edema / Q000453:epidemiology* / Q000209:etiology; D002545:Brain Ischemia / Q000453:epidemiology* / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000209:etiology; D002681:China / Q000453:epidemiology; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011225:Pre-Eclampsia; D011247:Pregnancy; D012307:Risk Factors