A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR).
We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.
Kohonen-Corish
M R
MR
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Wang
Y
Y
Doe
W F
WF
D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D017931:DNA Primers; D005787:Gene Frequency; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D055293:Receptors, Urokinase Plasminogen Activator; D012016:Reference Values; D012091:Repetitive Sequences, Nucleic Acid
D017931:DNA Primers; C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator