title: [Midazolam versus placebo before spinal anesthesia].
abstract: The goal of this randomized, double blind and multicentric study was to compare the effects of midazolam (M) and placebo (P) administered by titration before puncture for spinal anaesthesia on the comfort of 211 patients scheduled for elective surgery after oral premedication with hydroxyzine. The administered dose of midazolam was 3.4 +/- 1.3 mg (mean +/- SD). Anxiety was nil in 92% of the patients of the M group and in 64% of the patients of the P group (p < 0.001) and memorization of the pain of the puncture was reported in 34% of the patients of the M group and in 66% of the patients of the P group (p < 0.001). However cooperation of the patient and easiness of the puncture were similar in both groups. In conclusion titrated sedation with midazolam before puncture for spinal anaesthesia increases the comfort of the patient.
authors.affiliation: Service d'Anesthésie-Réanimation, Hôpital de Bicêtre, Le Kremlin-Bicêtre.
authors.forename: D
authors.initials: D
authors.lastname: Fletcher
authors.forename: K
authors.initials: K
authors.lastname: Samii
authors.forename: A
authors.initials: A
authors.lastname: Bénichou
authors.forename: D
authors.initials: D
authors.lastname: Fillette
authors.forename: A
authors.initials: A
authors.lastname: Bertin
authors.forename: M
authors.initials: M
authors.lastname: Germond
authors.forename: D
authors.initials: D
authors.lastname: Laverdisse
authors.forename: J M
authors.initials: JM
authors.lastname: Mascaro
authors.forename: E
authors.initials: E
authors.lastname: Normand
authors.forename: Y
authors.initials: Y
authors.lastname: Piroelle
mesh_terms: D000759:Adjuvants, Anesthesia; D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D001007:Anxiety / Q000188:drug therapy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D010919:Placebos
chemical_list: D000759:Adjuvants, Anesthesia; D006993:Hypnotics and Sedatives; D010919:Placebos; D008874:Midazolam
vernacular_title: Midazolam versus placebo avant rachianesthésie.