title: 3D domain swapping: a mechanism for oligomer assembly.
abstract: 3D domain swapping is a mechanism for forming oligomeric proteins from their monomers. In 3D domain swapping, one domain of a monomeric protein is replaced by the same domain from an identical protein chain. The result is an intertwined dimer or higher oligomer, with one domain of each subunit replaced by the identical domain from another subunit. The swapped "domain" can be as large as an entire tertiary globular domain, or as small as an alpha-helix or a strand of a beta-sheet. Examples of 3D domain swapping are reviewed that suggest domain swapping can serve as a mechanism for functional interconversion between monomers and oligomers, and that domain swapping may serve as a mechanism for evolution of some oligomeric proteins. Domain-swapped proteins present examples of a single protein chain folding into two distinct structures.
authors.affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104-6059, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bennett
authors.forename: M P
authors.initials: MP
authors.lastname: Schlunegger
authors.forename: D
authors.initials: D
authors.lastname: Eisenberg
mesh_terms: D042846:CDC2-CDC28 Kinases; D002352:Carrier Proteins / Q000737:chemistry; D018797:Cell Cycle Proteins; D004722:Endoribonucleases / Q000737:chemistry; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000737:chemistry; D015848:Interleukin-5 / Q000737:chemistry; D046911:Macromolecular Substances; D008958:Models, Molecular; D011494:Protein Kinases; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D012259:Ribonuclease, Pancreatic / Q000737:chemistry
chemical_list: D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D015848:Interleukin-5; D046911:Macromolecular Substances; D011506:Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D011494:Protein Kinases; D042846:CDC2-CDC28 Kinases; C083689:CKS2 protein, human; D004722:Endoribonucleases; C032523:ribonuclease SPL; D012259:Ribonuclease, Pancreatic