title: Rakicidins, new cytotoxic lipopeptides from Micromonospora sp. fermentation, isolation and characterization.
abstract: The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2,4-dienoic acid, 3-hydroxy-2,4,16-trimethyl-heptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the M109 cell line.
authors.affiliation: Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: McBrien
authors.forename: R L
authors.initials: RL
authors.lastname: Berry
authors.forename: S E
authors.initials: SE
authors.lastname: Lowe
authors.forename: K M
authors.initials: KM
authors.lastname: Neddermann
authors.forename: I
authors.initials: I
authors.lastname: Bursuker
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: S E
authors.initials: SE
authors.lastname: Klohr
authors.forename: J E
authors.initials: JE
authors.lastname: Leet
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005285:Fermentation; D055666:Lipopeptides; D051379:Mice; D008847:Micromonospora / Q000378:metabolism*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured; D047630:Depsipeptides
chemical_list: D000903:Antibiotics, Antineoplastic; D055666:Lipopeptides; D010456:Peptides, Cyclic; C000723972:rakicidins; D047630:Depsipeptides