title: The function of dynamin in endocytosis.
abstract: Temperature-sensitive shibire mutants of Drosophila melanogaster become rapidly paralyzed upon a shift to the restrictive temperature, which is due to a block in synaptic vesicle endocytosis. The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated clathrin-coated pits, and have suggested that a conformational change in the ring, which correlates with GTP hydrolysis, plays an essential role in vesicle fission.
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. pietro-decamilli@quickmail.yale.edu
authors.forename: P
authors.initials: P
authors.lastname: De Camilli
authors.forename: K
authors.initials: K
authors.lastname: Takei
authors.forename: P S
authors.initials: PS
authors.lastname: McPherson
mesh_terms: D000818:Animals; D029721:Drosophila Proteins; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000502:physiology*; D008958:Models, Molecular; D017729:Presynaptic Terminals / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; D020558:GTP Phosphohydrolases; D034281:Dynamins; C439628:shi protein, Drosophila