Prevention of glomerular hypertrophy and glomerulosclerosis in Milan normotensive rats by low-protein diet, but not by low-dose captopril treatment.
Milan normotensive rats, which spontaneously develop marked proteinuria (PU) and glomerulosclerosis (GS), were either kept on a normal-protein diet, a normal-protein diet with additional low-dose captopril (CAP), which did not affect blood pressure, or on a low-protein diet. After 8 months PU (79 +/- 25 mg/day) GS (3 +/- 2%) and total glomerular volume (TGV; 27.9 +/- 2.9 mm3/kidney) were significantly lower (p < 0.05) in the low-protein diet group than in both the normal-protein group (PU 583 +/- 210 mg/day, GS 12 +/- 5%, TGV 34.6 +/- 8 mm3/kidney) and the low-CAP group (PU 611 +/- 224 mg/day, GS 16 +/- 6%, TGV 41.8 +/- 8.6 mm3/kidney). In conclusion, the development of glomerular hypertrophy and GS in Milan normotensive rats was reduced by the low-protein diet, but not by low-CAP treatment.
Kliem
V
V
Department of Internal Medicine, Hannover Medical School, Germany.
Brunkhorst
R
R
Ehlerding
G
G
Kühn
K
K
Neumann
K H
KH
Koch
K M
KM
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D002216:Captopril / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine; D018753:Diet, Protein-Restricted; D004305:Dose-Response Relationship, Drug; D005923:Glomerulosclerosis, Focal Segmental / Q000178:diet therapy / Q000517:prevention & control / Q000628:therapy*; D006984:Hypertrophy / Q000517:prevention & control; D007444:Inulin / Q000652:urine; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation
D000806:Angiotensin-Converting Enzyme Inhibitors; D007444:Inulin; D002216:Captopril; D003404:Creatinine