[Effect of zinc-metallothionein on lipid peroxidation in blood plasma and in mouse liver in acute alcoholic intoxication].
The reduction of malondialdehyde (MDA) content in mouse blood plasma and liver 1h-1 day after the acute ethanol poisoning (3 g/kg) was discovered. Rat liver zinc-metallothionein in a dose 2 mg/kg inoculated before the alcohol introduction restored the MDA level to norm; at the same time the mixture which modulated this protein (albumin, cysteine and zinc) had only the tendency to normalization of the MDA level. On the third day after the poisoning in all cases the 2-2.5 times increase of the plasma MDA level was shown, but the liver MDA content did not change in comparison with the control. The number of the possible explanation of reduction of plasma lipid peroxidation level in the early time after the ethanol poisoning was proposed (hypoxy, aldehyde dehydrogenase activation etc.). It is supposed that zinc-metallothionein influence is connected with its capacity to inactivate acetaldehyde.
Koterov
A N
AN
Shilina
N M
NM
D000435:Alcoholic Intoxication / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008668:Metallothionein / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D015032:Zinc / Q000494:pharmacology*
C021267:zinc thionein; D008315:Malondialdehyde; D008668:Metallothionein; D015032:Zinc
Vliianie tsink-metallotioneina na perekisnoe okislenie lipidov v plazme krovi i v pecheni mysheĭ pri ostroĭ alkogol'noĭ intoksikatsii.