Risk factors for non-insulin-dependent diabetes mellitus.
RISK FACTORS AND PREDICTORS: The risk factors for non-insulin-dependent diabetes mellitus (NIDDM) include age, overall adiposity, an adverse body fat distribution, adverse glucose and insulin concentrations, insulin resistance and lack of physical exercise. The strongest predictors of NIDDM appear to be metabolic factors, including impaired glucose tolerance and insulin resistance.


METHODS
Pharmacological agents that improve insulin sensitivity are being tested in multicenter clinical trials. In patients with a high risk of NIDDM, it seems prudent to avoid the use of pharmacologic agents that increase insulin resistance.
Haffner
S M
SM
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7873, USA.
D000273:Adipose Tissue / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D003327:Coronary Disease / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity; D011384:Proinsulin / Q000502:physiology; D012307:Risk Factors
D001786:Blood Glucose; D011384:Proinsulin