[Cholestatic hepatitis and amoxicillin-clavulanic acid combination. Personnel case report and literature review].
The association amoxicillin-clavulanic acid is a widely used medication. Only about 15 cases of cholestatic hepatitis were reported in Belgium between 1990 and 1993; about 100 cases have been reported to the pharmaceutical company. This effect is severe but reversible. The injury is probably idiosyncratic or immunologically based. Age, sex and treatment duration are as many agents of risk. The diagnosis is undertaken on basis of clinical examination, chronological study, biological evolution and histology.
Watteeuw
G
G
Hôpital Universitaire Saint-Pierre, Service de Médecine Interne, Bruxelles.
Vasilevski
D
D
Hautekeete
M
M
Taton
G
G
Lambilliotte
J P
JP
François
E
E
Adler
M
M
D000367:Age Factors; D000658:Amoxicillin / Q000009:adverse effects; D019980:Amoxicillin-Potassium Clavulanate Combination; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D002969:Clavulanic Acids / Q000009:adverse effects; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Hépatite cholostatique et association amoxicilline-acide clavulanique. Observation personnelle et revue de la littérature.