title: Cyclosporin-induced remission in an infant with alkylating agents-resistant nephrotic syndrome. A case report.
abstract: The efficacy of cyclosporin-A, a potent immunosuppressive agent, has not been clearly proven in the management of childhood nephrotic syndrome. The occurrence of early relapse as the dose of cyclosporin is tapered or as soon as the drug is stopped and the potential nephrotoxic effects of prolonged treatment have caused it to be used in limited cases. We report an eighteen-month-old boy with steroid toxicity and alkylating agents-resistant nephrotic syndrome, who subsequently went very quickly into remission lasting at least one year after receiving cyclosporin-A for only three months.
authors.affiliation: Department of Pediatrics, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: G G
authors.initials: GG
authors.lastname: Yilmaz
authors.forename: A G
authors.initials: AG
authors.lastname: Güven
mesh_terms: D000477:Alkylating Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D004487:Edema / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy*; D011507:Proteinuria / Q000209:etiology; D012008:Recurrence
chemical_list: D000477:Alkylating Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine