title: Amnioinfusion for preventing puerperal infection. A prospective study.
abstract: OBJECTIVE
  To evaluate the hypothesis that irrigation of the uterine cavity by amnioinfusion in women with membranes ruptured for greater than six hours would decrease maternal puerperal infection.
  
  
  METHODS
  We designed a prospective study at three teaching institutions. Sixty-eight women were randomized to receive either amnioinfusion or routine care. Amnioinfusion was through preexisting internal uterine pressure catheters with a 300-500-mL bolus and a 125-150 mL/h constant drip. Chorioamnionitis and endometritis were evaluated as the outcome variables.
  
  
  RESULTS
  Women from the amnioinfusion group, n = 36, and the control group, n = 32, had similar times in labor (mean 4 hours), times of ruptured membranes (mean 18 hours), vaginal examinations (mean 7), gestational age (mean 40 weeks), types of anesthesia and methods of delivery. Women who received amnioinfusion had significantly less puerperal infection, 9/36, as compared to women in the control group, 16/32 (P < .033, relative risk = .5, confidence interval .26-.94). There were no cases of neonatal sepsis in either group, and there were no complications from the amnioinfusions.
  
  
  CONCLUSIONS
  In this study of women at high risk for puerperal infection, amnioinfusion was an inexpensive and safe technique for reducing the incidence of infection.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill 27599-7570, USA.
authors.forename: E
authors.initials: E
authors.lastname: Monahan
authors.forename: V L
authors.initials: VL
authors.lastname: Katz
authors.forename: R L
authors.initials: RL
authors.lastname: Cox
mesh_terms: D000293:Adolescent; D000328:Adult; D000650:Amnion; D002821:Chorioamnionitis / Q000209:etiology*; D016001:Confidence Intervals; D004716:Endometritis / Q000209:etiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications* / Q000628:therapy*; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011446:Prospective Studies; D011644:Puerperal Disorders / Q000209:etiology*; D012306:Risk; D007507:Therapeutic Irrigation / Q000379:methods*; D013997:Time Factors