title: Hydrocephalus, mineralizing angiopathy, hypercholesterolemia, and hyperlipoprotein (a).
abstract: A boy born at 34 weeks gestation with initially normal development presented with acute hydrocephalus at 22 months. Subsequently his development has been slow and complicated clinically by epilepsy. Upon extensive investigation, he has been found to have extremely elevated lipoprotein(a) levels, hypercholesterolemia (familial), and lesions of the cortex and meninges. Radiologic studies have disclosed a mineralizing angiopathy.
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, Canada.
authors.forename: A Y
authors.initials: AY
authors.lastname: Manzur
authors.forename: K J
authors.initials: KJ
authors.lastname: Poskitt
authors.forename: M G
authors.initials: MG
authors.lastname: Norman
authors.forename: J
authors.initials: J
authors.lastname: Frohlich
authors.forename: J U
authors.initials: JU
authors.lastname: Crichton
mesh_terms: D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005355:Fibrosis; D006801:Humans; D006849:Hydrocephalus / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006938:Hyperlipoproteinemia Type II / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D007223:Infant; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D011859:Radiography
chemical_list: D002556:Cerebrospinal Fluid Proteins; D008078:Cholesterol, LDL; D017270:Lipoprotein(a)