title: Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus).
abstract: A malignant melanocytic tumor was found in an 8-week-old chicken. The tumor, which was composed of melanocytes, ganglion cells, nerves, and primitive pressure receptors, was examined by light microscopy, transmission electron microscopy, and immunohistochemistry. Antibodies to neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein variably stained nerves, but melanocytes were only rarely immunolabelled by NSE antibodies and there was no specific staining of these cells for S-100 or GFAP. Ultrastructurally, neoplastic melanocytes contained melanin within melanosomes and premelanosomes and did not resemble Schwann cells.
authors.forename: S
authors.initials: S
authors.lastname: Hafner
authors.forename: K
authors.initials: K
authors.lastname: Latimer
authors.forename: L C
authors.initials: LC
authors.lastname: Kelley
authors.forename: K
authors.initials: K
authors.lastname: Wortham
authors.forename: M
authors.initials: M
authors.lastname: Puette
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry; D008545:Melanoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron / Q000662:veterinary; D009432:Neural Crest / Q000473:pathology*; D011201:Poultry Diseases / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000473:pathology
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins