title: Pooled patient samples as reference material for D-Dimer.
abstract: A low-D-Dimer concentration has a high negative predictive value for thromboembolic events. Actual and proposed applications include exclusion diagnosis of DIC, DVT and pulmonary embolism (1-7), follow up of cancer therapy (8) and diagnosis of abruptio placentae(9). A variety of tests are commercially available. Unfortunately, due to differences in standardization protocols, the cut-off normal/pathological of one test can usually not be used for another(10). As was shown by Nieuwenhuizen, one way to at least reduce these discrepancies is to use patient material as a reference(11). We have used this approach to standardize the latex test Tinaquant a D-Dimer against the ELISA test Asserachrom D-Dimer.
authors.affiliation: Boehringer Mannheim, Tutzing, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Adema
authors.forename: U
authors.initials: U
authors.lastname: Gebert
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D012016:Reference Values; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen