title: Preparation and use of fibrin glue in surgery.
abstract: Fibrin glue (FG) is used to control bleeding, to adhere tissues together, and to seal tissue defects. FG is prepared from platelet-rich plasma or by mixing concentrated fibrinogen solutions with thrombin. Concentrated fibrinogen solutions are produced by cryoprecipitation or by chemical precipitation of plasma. The literature on FG preparation is reviewed in order to compare the advantages and disadvantages of the different products reported and to summarize the clinical applications. It is concluded that additional studies are needed to fully evaluate the advantages and disadvantages of fibrinogen concentrated using cryoprecipitation and chemical precipitation and that specific advantages exist for use of both pooled homologous and autologous blood.
authors.affiliation: Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854, USA.
authors.forename: F H
authors.initials: FH
authors.lastname: Silver
authors.forename: M C
authors.initials: MC
authors.lastname: Wang
authors.forename: G D
authors.initials: GD
authors.lastname: Pins
mesh_terms: D000645:Ammonium Sulfate / Q000737:chemistry; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D011232:Chemical Precipitation; D003080:Cold Temperature; D000431:Ethanol / Q000737:chemistry; D015718:Fibrin Tissue Adhesive / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D005340:Fibrinogen / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D013514:Surgical Procedures, Operative / Q000639:trends*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D000431:Ethanol; D011092:Polyethylene Glycols; D005340:Fibrinogen; D000645:Ammonium Sulfate