title: Acceptability of HIV vaccine trials in high-risk heterosexual cohorts in Mombasa, Kenya.
abstract: OBJECTIVE
  To ascertain the level of acceptance of a prophylactic HIV vaccine trial in high-risk HIV-seronegative heterosexual cohorts of men and women in Mombasa, Kenya, and to assess the anticipated effects of participation on risk behavior.
  
  
  METHODS
  Standardized questionnaire administered to a convenience sample of commercial sex workers and trucking company employees enrolled in prospective cohort studies.
  
  
  RESULTS
  Ninety-six per cent of respondents believed that HIV was a major problem in Kenya and 86% of men and 94% of women perceived themselves at risk. One hundred per cent of women and 84% of men expressed interest in participation in an HIV vaccine trial, after explanation of the experimental nature of the vaccine, double-blind placebo-controlled design, prolonged follow-up and potential change in serostatus. Seventeen per cent of men and 9% of women anticipated an increase in risk behavior as a result of participation.
  
  
  CONCLUSIONS
  The majority of individuals in two high-risk cohorts were interested in participating in Phase III efficacy trials of HIV vaccines. A significant minority anticipated an increase in risk behavior, which emphasizes the need for intensive counseling and education throughout a vaccine trial.
authors.affiliation: Department of Epidemiology, University of Washington, Seattle 98104-2499, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Jackson
authors.forename: H L
authors.initials: HL
authors.lastname: Martin
authors.forename: J J
authors.initials: JJ
authors.lastname: Bwayo
authors.forename: P M
authors.initials: PM
authors.lastname: Nyange
authors.forename: J P
authors.initials: JP
authors.lastname: Rakwar
authors.forename: F
authors.initials: F
authors.lastname: Kashonga
authors.forename: K
authors.initials: K
authors.lastname: Mandaliya
authors.forename: J O
authors.initials: JO
authors.lastname: Ndinya-Achola
authors.forename: J K
authors.initials: JK
authors.lastname: Kreiss
mesh_terms: D016915:AIDS Vaccines / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D018023:HIV Seronegativity; D006801:Humans; D007630:Kenya; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012725:Sexual Behavior; D011795:Surveys and Questionnaires
chemical_list: D016915:AIDS Vaccines