Transendoscopic electrocautery-induced gastric ulcers as a model for gastric healing studies in ponies.
The ponies were apparently healthy and 6-20 months of age. In Study 1, gastric lesions were created by transendoscopic electrocautery in the non-glandular gastric mucosa, adjacent to the margo plicatus in 9 ponies which were then treated with water, 12 mg cimetidine HCl/kg bwt or 18 mg cimetidine HCl/kg bwt per os every 12 h for 35 days. In Study 2, gastric lesions were similarly induced in 9 ponies in the non-glandular mucosa and also in the glandular mucosa just below the non-glandular lesion on the greater curvature of the stomach. The ponies were treated with water, 8 mg cimetidine/kg bwt or 16 mg cimetidine/kg bwt per os every 8 h for 21 days. In both studies gastric lesion healing was monitored twice weekly by video gastroscopy. There was no apparent difference in healing times between the water and cimetidine treatment groups in either study. These results indicate that uniform gastric ulcers can be created by transendoscopic electrocautery in the non-glandular mucosa of ponies and that these ulcers heal at a predictable rate which should be useful in studying compounds that might accelerate healing of gastric mucosal lesions. However, cimetidine was not effective in accelerating the rate of healing under the conditions of this study.
MacAllister
C G
CG
Department of Medicine and Surgery, Oklahoma State University, Stillwater 74078, USA.
Lowrey
F
F
Stebbins
M
M
Newman
M S
MS
Young
B
B
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004564:Electrocoagulation / Q000009:adverse effects / Q000662:veterinary*; D016145:Endoscopy, Digestive System / Q000662:veterinary; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D006734:Horse Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D006736:Horses; D008297:Male; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D014945:Wound Healing / Q000502:physiology
D000897:Anti-Ulcer Agents; D002927:Cimetidine