The down-regulated in adenoma (DRA) gene encodes an intestine-specific membrane glycoprotein.
The protein product of the DRA gene, a gene whose expression is down-regulated in colon adenomas and adenocarcinomas, is a membrane glycoprotein and a member of a family of sulfate transporters. It is expressed in the intestinal tract (duodenum, ileum, cecum, distal colon), but not in the esophagus or stomach. DRA mRNA expression is restricted to the mucosal epithelium, and DRA protein expression is further limited to the columnar epithelial cells, particularly to the brush border. Consistent with its expression in the differentiated columnar epithelium of the adult human colon, DRA is first expressed in the midgut of developing mouse embryos at day 16.5, corresponding with the time of differentiation of the epithelium of the small intestine. A model for the structure of the DRA protein is proposed and its possible role in colon tumorigenesis is discussed.
Byeon
M K
MK
Center for Molecular and Structural Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, USA.
Westerman
M A
MA
Maroulakou
I G
IG
Henderson
K W
KW
Suster
S
S
Zhang
X K
XK
Papas
T S
TS
Vesely
J
J
Willingham
M C
MC
Green
J E
JE
Schweinfest
C W
CW
D000818:Animals; D017920:Antiporters; D002352:Carrier Proteins / Q000235:genetics*; D002478:Cells, Cultured; D003106:Colon / Q000378:metabolism; D003110:Colonic Neoplasms / Q000235:genetics; D018076:DNA, Complementary / Q000032:analysis; D004622:Embryo, Mammalian / Q000378:metabolism; D006031:Glycosylation; D007422:Intestines / Q000737:chemistry*; D008562:Membrane Glycoproteins / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D012333:RNA, Messenger / Q000032:analysis; D000076988:Sulfate Transporters
D017920:Antiporters; D002352:Carrier Proteins; D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D012333:RNA, Messenger; C489860:Slc26a3 protein, mouse; D000076988:Sulfate Transporters