Mineral bioavailability and bone mineral contents in pigs given calcium carbonate postprandially.
We have further investigated the "meal effect" on mineral bioavailability in pigs by mineral balance studies and measurements of bone ash contents and bending moment. A group of seven pigs (CAA) was given all its dietary Ca as CaCO3 5 h after the first daily meal for 8 weeks. The control group of seven pigs received CaCO3 in the meal. Both groups were given normal P within the meals. Ca and P absorption and retention were evaluated by a 10-day balance trial. Several bones were collected at slaughter to determine bone ash, Ca, and P contents and bending moment (three-point bending test). Ingesting Ca after the meal did not affect Ca bioavailability or phosphorus absorption, but did reduce P retention, which in turn decreased the bone scores. Osteopenia, indicated by decreased total mineral contents of bones (and decreased ash:bone volume ratio), was associated with elevated plasma osteocalcin in the CAA group. Thus, CaCO3 need not be incorporated into a meal for high Ca absorption, provided that Ca is given after a meal, but simultaneous intakes of Ca and P are required for the best mineral retention.
Pointillart
A
A
Laboratoire de Nutrition et Sécurité Alimentaire, INRA, Jouy-en-Josas, France.
Colin
C
C
Lacroix
H C
HC
Guéguen
L
L
D000042:Absorption; D000469:Alkaline Phosphatase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001682:Biological Availability; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015592:Immunoradiometric Assay; D008297:Male; D015675:Osteocalcin / Q000097:blood; D016226:Phosphorus, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013552:Swine; D013977:Tibia / Q000502:physiology
D002136:Calcium, Dietary; D016226:Phosphorus, Dietary; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002119:Calcium Carbonate