title: Central nervous system granulocytic sarcoma in a patient with essential thrombocythemia.
abstract: We report a rare case of central nervous system granulocytic sarcoma (GS) in a patient with essential thrombocythemia (ET). The diagnosis of GS was established by morphological and cytochemical findings (peroxidase and naphthol-AS-D-chloroacetate esterase positivity) of neoplastic cells. GS was detected as an intracranial frontal mass 7 months before the transformation of ET in acute myeloid leukemia and relapsed as two extradural spinal masses during the course of leukemic evolution.
authors.affiliation: Second Institute of Medical Clinics, University of Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Grande
mesh_terms: D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001752:Blast Crisis / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D002066:Busulfan / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D018450:Disease Progression; D004824:Epidural Space / Q000473:pathology*; D017809:Fatal Outcome; D005624:Frontal Bone / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D017254:Leukemic Infiltration / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D013115:Spinal Canal / Q000473:pathology; D013920:Thrombocythemia, Essential / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D003561:Cytarabine; D002066:Busulfan; D008775:Methylprednisolone; D003630:Daunorubicin