title: Safety of silver oxide-impregnated silastic tympanostomy tubes.
abstract: Otorrhea occurs after the insertion of tympanostomy tubes in as many as 50% of ears. Although topical antibiotic solutions minimize otorrhea in the immediate postoperative period, recurrent otorrhea is sometimes a clinical problem. The antimicrobial effects of silver oxide when impregnated into a tympanostomy tube may decrease the incidence of recurrent otorrhea. This study demonstrates that silver oxide-impregnated silicone elastomer is well tolerated within the middle ear of gerbils when implanted for 1 year, and the tissue reaction is no more than silicon elastomer without silver oxide. When applied directly to the round window of guinea pigs, there was no evidence of ototoxicity of silver oxide as measured by electrocochleography (N-1 thresholds) and cytocochleography (hair cell counts). These animal studies indicate that silver oxide-impregnated silicone elastomeric tympanostomy tubes may be used safely in clinical trials to determine efficacy.
authors.affiliation: Department of Otolaryngology, University of California at Davis 95616, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Chole
authors.forename: R E
authors.initials: RE
authors.lastname: Brummett
authors.forename: S P
authors.initials: SP
authors.lastname: Tinling
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D004343:Drug Implants; D004432:Ear, Middle / Q000033:anatomy & histology / Q000187:drug effects / Q000601:surgery; D005849:Gerbillinae; D006168:Guinea Pigs; D008297:Male; D008876:Middle Ear Ventilation / Q000295:instrumentation*; D010087:Oxides / Q000633:toxicity*; D012008:Recurrence; D012826:Silicone Elastomers; D018030:Silver Compounds / Q000633:toxicity*
chemical_list: D000890:Anti-Infective Agents; D004343:Drug Implants; D010087:Oxides; D012826:Silicone Elastomers; D018030:Silver Compounds; C040225:disilver oxide