title: [Postoperative radiotherapy in carcinoma of the pyriform sinus. Work of the "Groupe radiothérapie de la Féderation national des centres de lutte le cancer"].
abstract: Between January 1980 to December 1985, 248 patients with advanced squamous cell carcinoma of the pyriform sinus were retrospectively analysed. Criteria for inclusion in the study were the following: no previous treatment and treatment combining total pharyngolaryngectomy and postoperative radiotherapy. Mean follow up was 5 years with a minimum of 3 years. Seventy-one patients had a local regional recurrence (27.4%). Clinical staging at presentation and residual tumor at the primary site after surgery were factors significantly associated with higher local failure rates. The 5 year survival rate was 33% and the median survival time was 32 months (plateau was reached after the 6th year). The most frequent severe complication observed was pharyngeal stenosis occurring in 6% of the cases. This study confirms the poor prognosis of squamous cell carcinoma of the pyriform sinus, in spite of the combination of radical surgery and high dose postoperative radiotherapy.
authors.affiliation: Institut Jean-Godinot, Reims, Nancy, France.
authors.forename: T D
authors.initials: TD
authors.lastname: Nguyen
authors.forename: L
authors.initials: L
authors.lastname: Malissard
authors.forename: F
authors.initials: F
authors.lastname: Eschwege
authors.forename: X
authors.initials: X
authors.lastname: Panis
authors.forename: S
authors.initials: S
authors.lastname: Hoffstetter
authors.forename: G M
authors.initials: GM
authors.lastname: Jung
authors.forename: J M
authors.initials: JM
authors.lastname: Bachaud
authors.forename: B
authors.initials: B
authors.lastname: Prevost
authors.forename: R
authors.initials: R
authors.lastname: Quint
authors.forename: G
authors.initials: G
authors.lastname: Chaplain
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005602:France; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010611:Pharyngectomy; D011184:Postoperative Period; D011379:Prognosis; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D017211:Treatment Failure
vernacular_title: Radiothérapie postopératoire dans les cancers du sinus piriforme. Travail du groupe radiothérapie de la Fédération nationale des centres de lutte contre le cancer.