title: Cancer incidence, mortality and exposure-response among Swedish man-made vitreous fiber production workers.
abstract: OBJECTIVE
  The objective of this study was to provide an extended follow-up of workers in three Swedish plants producing man-made vitreous fibers (MMVF).
  
  
  METHODS
  Mortality and cancer incidence was investigated among 3539 male and female workers, employed for at least one year before 1978. Mortality was followed from 1952 to 1990 and cancer incidence from 1958 to 1989. National and regional mortality and cancer incidence rates were used to calculate the expected numbers.
  
  
  RESULTS
  Twenty-seven lung cancer deaths were observed compared with 23 expected (standardized mortality ratio 117, 95% confidence interval 81-176), based on regional mortality. With a latency time of 30 years, the lung cancer risk was significantly elevated, but not trend was found for the standardized mortality ratio with increasing duration of exposure to MMVF. The lung cancer and stomach cancer mortality was higher in the rock wool industry than in the fiber glass industry. Fiber exposure from 1938 to 1990 was estimated in the two rock wool plants by applying a model for historical fiber exposure estimation, specific for different job titles in the rock wool production industry. No relationship was found between individually cumulated rock wool fiber exposure and lung cancer or stomach cancer risk.
  
  
  CONCLUSIONS
  The numbers of lung cancers and stomach cancer cases were low and did not therefore allow more general conclusions regarding the cancer hazard for exposed workers. A large European study in progress will probably allow more precise conclusions.
authors.affiliation: Department of Occupational Health, Karolinska Hospital, Stockholm, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Plato
authors.forename: P
authors.initials: P
authors.lastname: Westerholm
authors.forename: P
authors.initials: P
authors.lastname: Gustavsson
authors.forename: T
authors.initials: T
authors.lastname: Hemmingsson
authors.forename: C
authors.initials: C
authors.lastname: Hogstedt
authors.forename: S
authors.initials: S
authors.lastname: Krantz
mesh_terms: D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D019016:Mineral Fibers / Q000009:adverse effects*; D009369:Neoplasms / Q000209:etiology / Q000401:mortality*; D009784:Occupational Diseases / Q000209:etiology / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology / Q000401:mortality; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology
chemical_list: D000395:Air Pollutants, Occupational; D019016:Mineral Fibers