[Prognostic significance of delayed cutaneous reactivity in 5-year survival in colorectal cancer: a prospective study].
A series of 84 patients operated on for colorrectal cancer-Duke's stages A:6, B:22, C:51 and D:5- are studied prospectively and with a 5 year follow-up. All of them were treated in the same hospital and with identical criteria during a period of time of two years. Immunoglobulins (A, G, M) and skin reactivity measured through a multiantigen device were determined preoperatively and at 48 hours and 30 days after operation. Data analysis was done once real survival at 5 years was known. Immunoglobulins changes showed no significance in relation to survival in this series. Preoperative skin reactivity values measured in mms demonstrated prognostic significance for patients in stage C when considering survivors -p < 0.05- and decreased -p < 0.01- at five years. Numerical values of skin reactivity done with a delayed hypersensitivity multiantigen compound may represent and additional prognostic factor to be considered in advanced colorrectal cancer patients.
Echenique Elizondo
M
M
Universidad del País Vasco, Unidad Docente de Medicina, San Sebastián.
Amondarain Arratibel
J
J
Lirón de Robles Sanz
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000276:immunology / Q000401:mortality* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012882:Skin Tests; D013997:Time Factors
D007136:Immunoglobulins
El valor pronóstico de la reactividad cutánea retardada en la supervivencia a 5 años en el cáncer colorrectal: un estudio prospectivo.