Screening for corticosteroid contact hypersensitivity.
To evaluate which corticosteroids are most useful for the detection of corticosteroid contact allergy in our population, 2123 patients were patch tested with a series of 6 corticosteroids, in parallel with a standard series, and other relevant investigations. 127 patients (5.98%) were allergic to one or more corticosteroids; 96 to tixocortol pivalate, 51 to hydrocortisone butyrate, 47 to budesonide, 11 to betamethasone valerate, 11 to clobetasone butyrate and 8 to clobetasol propionate. 511 patients with negative patch tests to the limited corticosteroid series were in addition tested to a further 12 corticosteroids; only 1 of these patients reacted to a corticosteroid. A combination of tixocortol pivalate and budesonide thus detected 91.3% of corticosteroid-allergic subjects. We believe that both these allergens should be included in the standard series and that there may be a case for extending this further.
Boffa
M J
MJ
Skin Hospital, University of Manchester School of Medicine, UK.
Wilkinson
S M
SM
Beck
M H
MH
D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010328:Patch Tests; D013256:Steroids
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D013256:Steroids