title: Disposable devices for the dispensing of oral drops. Study of photoprotectiveness and compatibility.
abstract: Amber-coloured syringes designed for the distribution of unit-doses of oral drops were studied for the efficiency of the photoprotectiveness and the possible binding of eleven phenothiazine neuroleptics: alimemazine, chlorpromazine, cyamemazine, fluphenazine, levomepromazine, periciazine, pipotiazine, prochlorperazine, thioproperazine, thioridazine, and trifluoperazine, all very easily oxidized in solution in daylight. Spectrofluorimetry made it possible, in one operation, to determine the remaining concentrations of drugs after storage and to verify the absence of photo-oxidation. The storage was performed up to 13 days at 25 +/- 3 degrees C and without any precaution from daylight. All the drugs studied were stable and none bound on the syringes. However, the stability appeared to be due to the antioxidants in the drug preparations, and not to the coloured material, since oral drops were also stable in uncoloured syringes designed for injection. Nevertheless, the amber-coloured syringes efficiently protect the active principles in pure aqueous solutions, without preservative, and thus this physical protection reinforces the chemical one of the galenical formulation.
authors.affiliation: Pharmacy of Valvert Hospital, Marseilles, France.
authors.forename: C B
authors.initials: CB
authors.lastname: Airaudo
authors.forename: A
authors.initials: A
authors.lastname: Gayte-Sorbier
authors.forename: M
authors.initials: M
authors.lastname: Froissart
authors.forename: C
authors.initials: C
authors.lastname: Machou
authors.forename: B
authors.initials: B
authors.lastname: Pion
mesh_terms: D000284:Administration, Oral; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D001672:Biocompatible Materials / Q000592:standards; D003116:Color; D004209:Disposable Equipment / Q000592:standards*; D016503:Drug Delivery Systems / Q000592:standards*; D004355:Drug Stability; D004356:Drug Storage / Q000592:standards; D008027:Light; D010084:Oxidation-Reduction; D010640:Phenothiazines
chemical_list: D014150:Antipsychotic Agents; D001672:Biocompatible Materials; D010640:Phenothiazines