title: [Long-term administration of benzodiazepines--disease follow-up, sequelae, treatment. A retrospective clinical record evaluation of 194 patients].
abstract: Clinical records of all patients treated from 1983 to 1991 in a university clinic for lang-term-use of benzodiazepines were examined. Daily intake of benzodiazepines began in 80% immediately after the first prescription. At the time of admission, 34% reported intake of more than 3 DDD, i.e. more than 30 mg of diazepam. In patients 70%, additional abuse of alcohol and/or other psychotropic substances was established. Benzodiazepines were the first substances abused in 49%. The diagnosis of abuse or dependency was made in 65% before admission. Symptoms of organic brain syndrome were described in 30% of all records. Symptom leading to first benzodiazepine intake were somatic complaints (40%), depressed mood (39%), insomnia (37% and anxiety (24%). Between first intake and admission, there was a significant increase in patients with somatic complaints, depressed mood and anxiety. After detocification, symptoms leading to admission improved in 80% of all patients.
authors.affiliation: Psychiatrische Klinik der Universität Erlangen-Nürnberg.
authors.forename: H J
authors.initials: HJ
authors.lastname: Luderer
authors.forename: M
authors.initials: M
authors.lastname: Schulz
authors.forename: M
authors.initials: M
authors.lastname: Mayer
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000175:diagnosis / Q000534:rehabilitation; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects; D001569:Benzodiazepines; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011619:Psychotropic Drugs / Q000009:adverse effects; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000209:etiology* / Q000534:rehabilitation
chemical_list: D014151:Anti-Anxiety Agents; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D001569:Benzodiazepines
vernacular_title: Langzeiteinnahme von Benzodiazepinen--Krankheitsentwicklung, Folgeerscheinungen, Behandlung. Eine retrospektive Krankenblattauswertung bei 194 Patienten.