title: Vestibular dysfunction in a child with embryonic exposure to accutane.
abstract: Children with a history of embryonic exposure to Accutane (isotretinoin) are at great risk for major physical malformations, brain malformations, and decreased intelligence. A case is presented of a 4-year 7-month-old black male with a history of embryonic exposure to Accutane who was born with embryopathy that includes bilateral major ear deformities. The child has a significant bilateral conductive hearing loss, and, in addition, a left sided sensorineural loss. Vestibular function testing revealed evidence of peripheral and central vestibular dysfunction. A course of diphenhydramine hydrochloride and Donnatal (phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide) significantly alleviated the symptoms of vestibular dysfunction. Otologic management of these children should include clinical documentation of the external deformities, evaluation of cochlear function, and early auditory habilitation. Vestibular function should also be evaluated in all children with a history of embryonic exposure to isotretinoin.
authors.affiliation: Hahnemann Medical College, Philadelphia, Pennsylvania, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Westerman
authors.forename: L M
authors.initials: LM
authors.lastname: Gilbert
authors.forename: L
authors.initials: L
authors.lastname: Schondel
mesh_terms: D002675:Child, Preschool; D004431:Ear, External / Q000002:abnormalities*; D007758:Ear, Inner / Q000033:anatomy & histology / Q000502:physiology; D004584:Electronystagmography; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006314:Hearing Loss, Conductive / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D009759:Nystagmus, Pathologic; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015837:Vestibular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000503:physiopathology*
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin