Photodynamic eradication of amelanotic melanoma of the hamster with fast acting photosensitizers.
Three porphycenes with fast pharmacokinetics were tested for their ability to photosensitize amelanotic hamster melanoma A-Mel-3 at short time intervals after injection. Laser light irradiation was performed at the time of maximal photosensitizer level in tumor tissue. Photodynamic therapy as short as 5 min after injection led to complete local tumor remission at a dosage of 1.4 mumol/kg for the porphycene CBPn. In comparison, Photofrin required 8.4 mumol/kg for local tumor remission in 5 of 6 animals with 24 hr accumulation time after injection. We propose a swift photodynamic protocol which can compete favorably with conventional techniques of tumor treatment.
Dellian
M
M
Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
Richert
C
C
Gamarra
F
F
Goetz
A E
AE
D000818:Animals; D006224:Cricetinae; D018328:Melanoma, Amelanotic / Q000628:therapy*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010789:Phototherapy; D011166:Porphyrins / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000628:therapy*
D017319:Photosensitizing Agents; D011166:Porphyrins; C051407:porphycene