[Value of the use of milrinone in the treatment of acute crisis in patients with congestive heart failure].
OBJECTIVE
To assess the hemodynamic effects of milrinone in a 48h intravenous infusion in patients with severe congestive heart failure (CHF) (NYHA class III or IV).


METHODS
Forty patients with CHF were sequentially evaluated. Right heart catheterization was performed in order to measure, before and after administration of milrinone, several hemodynamic parameters (cardiac index, pulmonary wedge pressure, systemic and pulmonary vascular resistance).


RESULTS
There was a significant improvement in hemodynamic parameters (cardiac index, cardiac output), and a decrease in systemic vascular resistance and pulmonary vascular resistance. Serious side effects were not observed in these patients.


CONCLUSIONS
These findings indicate that milrinone is effective in the treatment of deteriorating phases of CHF and suggest that milrinone should be used in these select patients.
Gun
C
C
Instituto Dante Pazzanese de Cardiologia, São Paulo.
Piegas
L S
LS
Bianco
A C
AC
Freire
R B
RB
Ramos
R F
RF
Timerman
A
A
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D005260:Female; D006333:Heart Failure / Q000145:classification / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D020105:Milrinone; D011446:Prospective Studies; D011728:Pyridones / Q000008:administration & dosage*
D002316:Cardiotonic Agents; D011728:Pyridones; D020105:Milrinone
Valor do uso da milrinona no tratamento das crises de agudização em portadores de insuficiência cardíaca congestiva.