title: Experimental model of chronic tonsillar herniation associated with early stage syringomyelia.
abstract: This report describes an experimental model of chronic tonsillar herniation and its effects on the spinal cord. In ten rats, a small piece of chemically induced mammary cancer was transplanted to the supraoccipital bone. In all cases, the transplanted cancers grew into the posterior fossa, destroying the supraoccipital bone and compressing the cerebellum extradurally. In six of the ten rats, tonsillar herniation was observed at 8-14 weeks after transplantation. Transdural infiltration of the tumor cells was not apparent in any animal. In those rats with tonsillar herniation (n = 6), the spinal cord from the C5 to the T8 segments showed enlargement of the central canal without exception. Histological examination revealed the following changes: stretching and thinning of the ependymal cells; swelling of the astrocytic processes; and extra-cellular edema, predominantly in the dorsal gray matter, but also in the ventral inner portion of the dorsal column. In the control group (n = 4) and those rats without tonsillar herniation (n = 4), such histological changes of the spinal cord were not observed. Although the lesions can not be regarded as representing mature syringomyelia, they most likely constitute an earlier evolutionary stage.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: S
authors.initials: S
authors.lastname: Tachibana
authors.forename: N
authors.initials: N
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Yada
authors.forename: E
authors.initials: E
authors.lastname: Ohama
mesh_terms: D000818:Animals; D002526:Cerebellar Diseases / Q000150:complications / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology / Q000648:ultrastructure; D004195:Disease Models, Animal; D005260:Female; D008854:Microscopy, Electron; D051381:Rats; D011916:Rats, Inbred F344; D013116:Spinal Cord / Q000473:pathology; D013595:Syringomyelia / Q000150:complications / Q000473:pathology*