title: CYP2D6 genotypes in Spanish women with breast cancer.
abstract: Wild type and three mutated alleles of the polymorphic CYP2D6 gene were studied in genomic DNA samples from 187 women with breast carcinoma and 151 healthy women by a mutation-specific polymerase chain reaction. The prevalence of the enzyme-inactivating CYP2D6(B) allele was higher among patients (18.2%) than in controls (11.6%; OR = 1.7; 95% c.i. = 1.14-3.13; P = 0.018). This excess was more marked in postmenopausal patients (19.8%, P = 0.0086) and in patients with non-ductal infiltrating carcinomas (25.8%, P = 0.003). The percentage of carriers of only one active gene (heterozygote extensive metabolizers) was higher in patients (31% vs. 19.9%; OR = 1.81; 95% c.i. = 1.06-3.11; P = 0.02). The CYP2D6(B)-carrier state may be related to a greater risk of breast cancer in women.
authors.affiliation: Department of Pharmacology, University of Extremadura, Badajoz, Spain.
authors.forename: M G
authors.initials: MG
authors.lastname: Ladona
authors.forename: R E
authors.initials: RE
authors.lastname: Abildúa
authors.forename: J M
authors.initials: JM
authors.lastname: Ladero
authors.forename: J M
authors.initials: JM
authors.lastname: Román
authors.forename: M A
authors.initials: MA
authors.lastname: Plaza
authors.forename: J A
authors.initials: JA
authors.lastname: Agúndez
authors.forename: J J
authors.initials: JJ
authors.lastname: Muñoz
authors.forename: J
authors.initials: J
authors.lastname: Benítez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics*; D011110:Polymorphism, Genetic; D013030:Spain
chemical_list: D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6