Integrin transmembrane signaling and cytoskeletal control.
Integrins are remarkably multifunctional: they mediate cell adhesion and migration, orchestrate organization of the actin-based cytoskeleton, and activate signal transduction pathways. Recent studies have identified a variety of steps and hierarchies in these intracellular cytoskeletal and signaling responses, laying the groundwork for future studies on specificity and coordination with responses to growth factors.
Yamada
K M
KM
Laboratory of Developmental Biology NIDR, NIH, Bethesda, MD 20892-4370, USA.
Miyamoto
S
S
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D016023:Integrins