Reduction of extracellular superoxide dismutase activity by decapeptide derived from FGF-receptor.
Several synthetic decapeptides containing an HAV tripeptide motif were tested for their ability to modulate the enzymatic activity of rat extracellular SOD, an enzyme which also contains an HAV motif. Out of nine decapeptides that were tested, only a FGF-receptor derived peptide was active as a negative modulator of enzyme activity. These results strengthen the thesis that HAV motifs are not only involved in homophilic interactions and suggest that soluble FGF-receptor molecules might moderate the activity of extracellular SOD.
Willems
J
J
Interdisciplinary Research Center; K.U. Leuven Campus Kortrijk, Belgium.
Noppe
W
W
Slegers
H
H
D000595:Amino Acid Sequence; D000818:Animals; D015820:Cadherins / Q000302:isolation & purification / Q000494:pharmacology*; D005910:Glioma; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000201:enzymology / Q000648:ultrastructure
D015820:Cadherins; D009842:Oligopeptides; D017468:Receptors, Fibroblast Growth Factor; D013482:Superoxide Dismutase