RES-701-2, -3 and -4, novel and selective endothelin type B receptor antagonists produced by Streptomyces sp. I. Taxonomy of producing strains, fermentation, isolation, and biochemical properties.
RES-701-2, -3 and -4, novel cyclic peptide endothelin antagonists, were isolated from the culture broths of Streptomyces sp. RE-701 and RE-896, RES-701s selectively inhibited the ET-1 binding to endothelin type B receptor (ETB receptor) with IC50 values ranging from 5 to 20 nM. Taxonomy of the producing strains, fermentation, isolation and biochemical properties of RES-701s are described.
Ogawa
T
T
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Japan.
Ochiai
K
K
Tanaka
T
T
Tsukuda
E
E
Chiba
S
S
Yano
K
K
Yamasaki
M
M
Yoshida
M
M
Matsuda
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D017077:Culture Media, Conditioned; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000378:metabolism; D005285:Fermentation; D006801:Humans; D008168:Lung / Q000378:metabolism; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017466:Receptors, Endothelin / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D017077:Culture Media, Conditioned; D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D010456:Peptides, Cyclic; C097812:RES 701-2; C097813:RES 701-3; C097814:RES 701-4; D017466:Receptors, Endothelin; D011994:Recombinant Proteins