title: Endometrial carcinoma associated with hyperplasia.
abstract: The aim of this study was to clarify the relationship of endometrial hyperplasia to endometrial carcinoma. From 1979 through 1990, 115 cases of stage I-IV endometrial carcinomas treated initially by hysterectomy were reviewed histologically. Forty-two of 115 (36.3%) patients had hyperplasia in the endometrium adjacent to the carcinoma. Women with both endometrial carcinoma and hyperplasia were significantly younger than those with carcinoma without hyperplasia (P < 0.05). In a comparison of patients with carcinoma without hyperplasia, those with hyperplasia were better differentiated (P = 0.0072), and lacked deep myometrial invasion (P < 0.0001), cervical involvement (P = 0.0192), lymph-vascular space invasion (P = 0.0102), and para-aortic lymph node metastases (P = 0.0434). The presence of endometrial metaplasia (P = 0.0001). The estimated 5-year survival rates for patients with carcinoma with hyperplasia and those with carcinoma without hyperplasia were 96.55 and 73.33%, respectively (P = 0.0016). In endometrial carcinomas, the presence of endometrial hyperplasia may demonstrate a more favorable prognosis.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University 60, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kaku
authors.forename: N
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Hachisuga
authors.forename: N
authors.initials: N
authors.lastname: Tsuruchi
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Hirakawa
authors.forename: S
authors.initials: S
authors.lastname: Amada
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Kamura
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D004714:Endometrial Hyperplasia / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D016889:Endometrial Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015996:Survival Rate