title: Management of rectourethral fistulas in Crohn's disease.
abstract: We report the thirteenth case of a recto-urethral fistula in Crohn's disease. The patient, a 37-year-old white male, had a 20-year history of intestinal Crohn's disease and had undergone numerous bowel resections. His symptoms were fecaluria, urorrhea and passing of urine from an orifice just outside the base of the scrotum. He had urinary infection and severe ileocolitis. He underwent a diagnostic evaluation (cystourethroscopy, proctoscopy, retrograde pyelography, intravenous urography, voiding cystourethrography) that revealed a fistula comprising the membranous urethra, the rectum, the perineum and the scrotum. He was treated with Metronidazole (20 mg/kg/day/12 mo). At 1 year no signs of intestinal disease and urinary sepsis were noted. The external orifice and the perineal fistulous network were closed, and the drainage from the rectum and the urethra had improved. No side effects limited use of the drug. No relapse was observed in the 3 months, after the therapy was discontinued. We present a review of the literature on the management of rectourethral fistulas in Crohn's disease. Surgeons have used successfully several approaches in the repair of this lesion, but no single procedure has proved optimal or even universally applicable. We emphasize, as the literature suggests, that the management must be individualized. Medical therapy with metronidazole has an important role in a patient with rectourethral fistula and concomitant proctitis, ileocolitis, urinary sepsis and multiple previous surgical procedures.
authors.affiliation: Department of General Surgery, 2nd Division, School of Medicine, University Federico II of Naples, Italy.
authors.forename: G A
authors.initials: GA
authors.lastname: Santoro
authors.forename: L
authors.initials: L
authors.lastname: Bucci
authors.forename: F A
authors.initials: FA
authors.lastname: Frizelle
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D010502:Perineum; D012003:Rectal Fistula / Q000175:diagnosis / Q000188:drug therapy*; D012611:Scrotum; D014522:Urethral Diseases / Q000175:diagnosis / Q000188:drug therapy*; D014548:Urinary Fistula / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D008795:Metronidazole