title: Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.
abstract: A fundamental question in the basic biology of aging is whether there is a universal aging process. If indeed such a process exists, one would expect that it develops at a higher rate in short- versus long-lived species. We have quantitated pentosidine, a marker of glycoxidative stress in skin collagen from eight mammalian species as a function of age. A curvilinear increase was modeled for all species, and the rate of increase correlated inversely with maximum life-span. Dietary restriction, a potent intervention associated with increased life-span, markedly inhibited glycoxidation rate in the rodent. On the assumption that collagen turnover rate is primarily influenced by the crosslinking due to glycoxidation, these results suggest that there is a progressive age-related deterioration of the process that controls the collagen glycoxidation rate. Thus, the ability to withstand damage due to glycoxidation and the Maillard reaction may be under genetic control.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Sell
authors.forename: M A
authors.initials: MA
authors.lastname: Lane
authors.forename: W A
authors.initials: WA
authors.lastname: Johnson
authors.forename: E J
authors.initials: EJ
authors.lastname: Masoro
authors.forename: O B
authors.initials: OB
authors.lastname: Mock
authors.forename: K M
authors.initials: KM
authors.lastname: Reiser
authors.forename: J F
authors.initials: JF
authors.lastname: Fogarty
authors.forename: R G
authors.initials: RG
authors.lastname: Cutler
authors.forename: D K
authors.initials: DK
authors.lastname: Ingram
authors.forename: G S
authors.initials: GS
authors.lastname: Roth
authors.forename: V M
authors.initials: VM
authors.lastname: Monnier
mesh_terms: D000375:Aging; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry; D002417:Cattle; D003094:Collagen / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004032:Diet; D004285:Dogs; D005947:Glucose / Q000737:chemistry; D006801:Humans; D008136:Longevity; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry; D008253:Macaca mulatta; D010084:Oxidation-Reduction; D051381:Rats; D012044:Regression Analysis; D012453:Saimiri; D012867:Skin / Q000737:chemistry; D013552:Swine
chemical_list: D003432:Cross-Linking Reagents; D003094:Collagen; D001120:Arginine; C062187:pentosidine; D005947:Glucose; D008239:Lysine