Effects of inhibitory amino acids on the frequency components in sympathetic nerve discharge.
The effects of the GABA antagonist picrotoxin and the glycine antagonist strychnine on the frequency components in sympathetic inferior cardiac nerve activity were observed. Picrotoxin (0.03-1.0 mg/kg) increased power in the 10-Hz component of sympathetic activity and produced a dramatic shift in the rhythm to higher frequencies. Only small changes were noted in the 2- to 6-Hz component. Strychnine produced a small generalized increase in power in both frequency bands in sympathetic activity. These data suggest that GABA may play an important role in the generation and maintenance of the 10-Hz rhythm in sympathetic activity while glycine likely inhibits activity at a site of convergence of the two rhythms in sympathetic activity.
Clement
M E
ME
The Upjohn Co., Kalamazoo, MI 49001, USA.
McCall
R B
RB
D000818:Animals; D002415:Cats; D004594:Electrophysiology; D018756:GABA Antagonists / Q000494:pharmacology; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D018684:Glycine Agents / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018756:GABA Antagonists; D005998:Glycine; D018684:Glycine Agents; D018377:Neurotransmitter Agents; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid