Some characteristics of the glutathione cycle revealed by ionising and non-ionising electromagnetic radiation.
The cyclic reaction of GSH-->GSSG-->GSH (designated R(exp) or R(e)) obeys the three specific features of life by producing energy in exponential quantities relative to time, is in effect irreversible and is inherited from generation to generation. In multicellular life, this reaction produces the energy for mitosis and is kept in controlled inactivity until needed to maintain perfection of form and function by energising mitosis. The immediate control of Re appears to be feedback process-dependent on the concentration of GSSG. Ultra high-frequency electromagnetic radiation of 434 MHz (UHF) will change Re from inactive to active and, in so doing, it causes resonance and/or fluorescence of the glutathione cycle which changes its radiosensitivity. Re is the primary direct target of ionising radiation and produces the energy for mitosis. Clinical observations suggest that, in the normal cell, Re is inactive and is not killed by 3 x 2700 rads or 6 x 1650 rads yet, when active, its sensitivity value (DO) is approximately 160 rads. Using the standard radiobiological equation of response to ionising radiation, it can be deduced that radiosensitive cancers have two or three Re units active per cell and radioresistance increases in proportion to the number of potentially active Re units per cell. Re appears to be the main cause of cancers' increased conductivity of electricity compared with normal tissue. In cancer therapy, UHF is the best radiosensitiser ever discovered (up to two or more decades). Re is also intelligent compared with non-exponential reactions but cannot be the basis of intellectual brain functions which must be based on non-electrical chemical processes.
Holt
J A
JA
Microwave Therapy Centre, West Perth, Australia.
D000293:Adolescent; D000328:Adult; D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D002962:Civilization; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004734:Energy Metabolism; D005246:Feedback; D005260:Female; D005978:Glutathione / Q000378:metabolism* / Q000528:radiation effects; D006019:Glycolysis; D006801:Humans; D006979:Hyperthermia, Induced; D007360:Intelligence; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D008875:Middle Aged; D008938:Mitosis; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy / Q000628:therapy*; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology; D000069497:Origin of Life; D010084:Oxidation-Reduction; D011157:Population Dynamics; D011827:Radiation; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage
D005978:Glutathione