Passive cutaneous anaphylaxis in diabetic rats.
The effect of diabetic condition on heterologous passive cutaneous anaphylaxis (PCA) reaction was studied. In alloxan diabetic rats, PCA reaction was inhibited by 68.2% of control values. The skin hyposensitivity in diabetic rats could not be attributed to a lower quantity of skin mast cells; it is suggested that alterations in the endothelial cells of the microcirculatory blood vessels decrease permeability to biologically active mast cell factors.
Casacó
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A
Department of Pharmacology, National Center for Scientific Research, Ciudad Habana, Cuba.
Merino
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N
González
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A
D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D005260:Female; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000496:Alloxan