Metabolic aspects of the treatment of hypertension.
INSULIN RESISTANCE AND HYPERTENSION: Hypertension is often associated with insulin resistance, which may be the underlying cause of hypertension in many cases. The whole complex of insulin resistance and its related factors appears to be based on a reduction in nutritional blood flow to large muscle groups. EFFECT OF TREATMENT: Blood flow is further reduced during beta-blockade but improves during alpha 1-blockade, which may explain the contrasting effects of these treatments on insulin resistance and triglyceride metabolism.
Lithell
H
H
Uppsala University, Sweden.
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D018482:Muscle, Skeletal / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014280:Triglycerides / Q000097:blood*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D014280:Triglycerides