title: Neuropsychiatry of obsessive-compulsive disorder in children and adolescents.
abstract: Physicians understanding of the pathobiobiology, diagnosis, and treatment of OCD in children and adolescents closely resembles that for OCD in adults. Moreover, it is now clear that OCD is a neurobehavioral disorder involving dysregulation in links between cortical and subcortical circuitry that is substantially influenced by serotonergic neurotransmission. Although current treatments are not generally curative, given a correct diagnosis and the skillful combination of pharmacotherapy with a serotonin reuptake inhibitor and focused cognitive-behavioral psychotherapy, most children can be helped to resume a normal developmental trajectory.
authors.affiliation: Department of Psychiatry and Psychology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: March
authors.forename: H L
authors.initials: HL
authors.lastname: Leonard
authors.forename: S E
authors.initials: SE
authors.lastname: Swedo
mesh_terms: D000293:Adolescent; D002648:Child; D002997:Clomipramine / Q000627:therapeutic use*; D006801:Humans; D009420:Nervous System / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D009460:Neurologic Examination; D018377:Neurotransmitter Agents / Q000378:metabolism; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D002997:Clomipramine; D018377:Neurotransmitter Agents; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors