title: Bilateral subthalamic nucleus stimulation for severe Parkinson's disease.
abstract: Subthalamic nucleus (STN) lesions or high-frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained < or = 15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.
authors.affiliation: Department of Clinical and Biological Neurosciences, Joseph Fourier University of Grenoble, France.
authors.forename: P
authors.initials: P
authors.lastname: Limousin
authors.forename: P
authors.initials: P
authors.lastname: Pollak
authors.forename: A
authors.initials: A
authors.lastname: Benazzouz
authors.forename: D
authors.initials: D
authors.lastname: Hoffmann
authors.forename: E
authors.initials: E
authors.lastname: Broussolle
authors.forename: J E
authors.initials: JE
authors.lastname: Perret
authors.forename: A L
authors.initials: AL
authors.lastname: Benabid
mesh_terms: D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D007839:Functional Laterality; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D012720:Severity of Illness Index; D013787:Thalamic Nuclei
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa