Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
Sakai
T
T
Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Gunma, Japan.
Kawai
H
H
Kamishohara
M
M
Odagawa
A
A
Suzuki
A
A
Uchida
T
T
Kawasaki
T
T
Tsuruo
T
T
Otake
N
N
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011684:Purine Nucleosides / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D011684:Purine Nucleosides; C015502:septacidin