Ovarian autoimmunity and corticotherapy in an in-vitro fertilization attempt.
This case report describes a successful pregnancy and delivery in a woman presenting with ovarian autoimmunity who had previously been involved in two unsuccessful in-vitro fertilization (IVF) attempts. Ten days before a third attempt, she began a regimen of 25 mg per day of prednisolone which was continued throughout the whole IVF protocol. Ovulation was induced by human menopausal gonadotrophin. After administration of 5000 IU of human chorionic gonadotrophin, 18 oocytes were collected. At 48 h after insemination with the patient's husband's spermatozoa, four 4-cell pre-embryos were transferred. A singleton pregnancy developed and led to the birth of a girl who is doing well 10 months later.
Barbarino-Monnier
P
P
In Vitro Fertilization Unit, Clinique Universitaire de Gynécologie Obstétrique, Maternité Régionale, Nancy, France.
Gobert
B
B
Guillet-May
F
F
Béné
M C
MC
Barbarino
A
A
Foliguet
B
B
Faure
G C
GC
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010053:Ovary / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome
D001323:Autoantibodies; D007136:Immunoglobulins; D011239:Prednisolone