title: [Several indicators of protein and nucleic acid metabolism in lymphoid organs of rats exposed to hypokinesia and vitamin B1 deficiency].
abstract: RNA, DNA, total protein, transketolase (TK), alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), methionyl-tRNA (met-tRNA)- and cysteinyl-tRNA (cys-tRNA)-synthetases in the thymus and spleen of 46 intact rats exposed to hypokinesia and vitamin B1 deficiency were measured. It was found that 15-day hypokinesia induced a significant decrease of the thymus and spleen weight and an increase of AlAT in the thymus. Vitamin B1 deficiency (hydroxy thiamine in drinking water at a dose of 2 mg/kg body weight for 15 days) led to a substantial decrease of TK in blood, AlAT and AsAT in the spleen; it diminished AsAT and increased AlAT in the thymus. Combined exposure to hypokinesia and vitamin B1 deficiency caused a more marked decrease of the weight of lymph organs, a significant loss of body weight, an increase of DNA in the thymus and spleen, and an increase of TK, met-tRNA-synthetase and AlAT in the thymus. These results suggest that vitamin B1 deficiency aggravates disorders in protein and nucleic acid metabolism in the lymph organs of hypokinetic animals.
authors.forename: L N
authors.initials: LN
authors.lastname: Dvorianinovich
authors.forename: V V
authors.initials: VV
authors.lastname: Klimovich
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D006948:Hyperkinesis / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism*; D013832:Thiamine Deficiency / Q000378:metabolism*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism*; D014174:Transketolase / Q000097:blood; D015431:Weight Loss
chemical_list: D011506:Proteins; D012313:RNA; D004247:DNA; D014174:Transketolase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Nekotorye pokazateli metabolizma belkov i nukleinovykh kislot v limfoidnykh organakh krys v usloviiakh gipokinezii i defitsita vitamina B1.