Huntington's disease. Their loss is our gain?
'Knockout' mice have been developed that lack the Huntington's disease gene, in an effort to gain insight into the disorder and into the pathophysiological effects of tri-nucleotide repeat expansion.
Feero
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Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.
Hoffman
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EP
D000818:Animals; D006801:Humans; D006816:Huntington Disease / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D018911:Trinucleotide Repeats