Surgical prophylaxis of familial colon cancer: prevention of death from familial colorectal cancer.
Patients at risk for inherited colorectal cancer constitute a heterogeneous population. A total colectomy is minimal treatment for those patients with invasive cancer or those with established risk factors. For others at risk, predictive genetic markers, correlated with clinical and pathologic determinants, will establish the basis for policies of surveillance and preventive surgery.
DeCosse
J J
JJ
Department of Surgery, New York Hospital-Cornell Medical Center, NY 10021, USA.
D000328:Adult; D017668:Age of Onset; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery; D017558:Elective Surgical Procedures; D005819:Genetic Markers; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012307:Risk Factors
D005819:Genetic Markers