title: Intralesional sustained-release chemotherapy with therapeutic implants for treatment of canine sun-induced squamous cell carcinoma.
abstract: Squamous cell carcinoma (SCC) is the most frequently reported malignant epithelial tumour in dogs. Canine sun-induced SCC represents a useful animal model to evaluate new therapeutic modalities for possible human applications. We evaluated the safety and efficacy of treating sun-induced SCC in dogs with intralesional sustained-released chemotherapeutic gel implants that contained collagen, epinephrine (epi), and either 5-fluorouracil (5-FU) or cisplatin (CDDP). Dogs with large, single SCC or fields of multiple SCC were treated with 5-FU/epi gel for a minimum of three weekly injections. Dogs without a complete response were then treated with CDDP/epi gel for a minimum of three weekly treatments. We treated from one to 11 primary, recurrent, or refractory SCC per dog (tumour size 0.2-92.4 cm2; mean cumulative tumour area of 40.7 cm2 per dog). All dogs had at least 50% reduction in cumulative tumour area after treatment with 5-FU/epi gel. More than half (seven of 13) had complete resolution of SCC after treatment with 5-FU/epi gel or CDDP/epi gel. Minimal local tissue reactions were noted; no systemic toxicity occurred. Sustained-release chemotherapy using intralesional 5-FU/epi gel and CDDP/epi gel therapeutic implants is effective in treating canine sun-induced SCC of the skin.
authors.affiliation: Special Veterinary Services, Berkeley, California, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Kitchell
authors.forename: E K
authors.initials: EK
authors.lastname: Orenberg
authors.forename: D M
authors.initials: DM
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Hutson
authors.forename: K
authors.initials: K
authors.lastname: Ray
authors.forename: L
authors.initials: L
authors.lastname: Woods
authors.forename: E
authors.initials: E
authors.lastname: Luck
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D004343:Drug Implants; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D013472:Sunlight / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D002945:Cisplatin; D005472:Fluorouracil