Recognition and specificity in protein tyrosine kinase-mediated signalling.
There are several factors that contribute to the specificities of protein tyrosine kinases (PTKs) in signal transduction pathways. While protein-protein interaction domains, such as the Src homology (SH2 and SH3) domains, regulate the cellular localization of PTKs and their substrates, the specificities of PTKs are ultimately determined by their catalytic domains. The use of peptide libraries has revealed the substrate specificities of SH2 domains and PTK catalytic domains, and has suggested cross-talk between these domains.
Songyang
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Division of Signal Transduction, Beth Israel Hospital, Boston, MA 02115, USA.
Cantley
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LC
D000595:Amino Acid Sequence; D001665:Binding Sites; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D010748:Phosphopeptides / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity; D018909:src Homology Domains
D010748:Phosphopeptides; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases