title: CO dehydrogenase.
abstract: Structurally and functionally diverse CO dehydrogenases are key components of various energy-yielding pathways in aerobic and anaerobic microbes from the Bacteria and Archaea domains. Aerobic microbes utilize Mo-Fe-flavin CO dehydrogenases to oxidize CO in respiratory pathways. Phototrophic anaerobes grow by converting CO to H2, a process initiating with a CO dehydrogenase that contains nickel and iron-sulfur centers. Acetate-producing anaerobes employ a nickel/iron-sulfur CO dehydrogenase to synthesize acetyl-CoA from a methyl group, CO, and CoA. A similar enzyme is responsible for the cleavage of acetyl-CoA by anaerobic Archaea that obtain energy by fermenting acetate to CH4 and CO2. Acetotrophic sulfate reducers from the Bacteria and Archaea also utilize CO dehydrogenase to cleave acetyl-CoA yielding methyl and carbonyl groups. These microbes obtain energy for growth via a respiratory pathway in which the methyl and carbonyl groups are oxidized to CO2, and sulfate is reduced to sulfide.
authors.affiliation: Department of Biochemistry, Microbiology, Molecular & Cell Biology, Pennsylvania State University, University Park 16802-4500, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Ferry
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D001420:Bacteria, Aerobic / Q000201:enzymology; D001421:Bacteria, Anaerobic / Q000201:enzymology; D002248:Carbon Monoxide / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D008667:Metalloproteins / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*
chemical_list: D007506:Iron-Sulfur Proteins; D008667:Metalloproteins; D009097:Multienzyme Complexes; D002248:Carbon Monoxide; D000445:Aldehyde Oxidoreductases; C019823:carbon monoxide dehydrogenase