The clinical significance of an autoimmune response against glutamic acid decarboxylase.
Glutamic acid decarboxylase is attracting much interest because of its putative involvement in two clinical disorders: stiffman syndrome and insulin-dependent diabetes. Here we discuss the clinical significance of an autoimmune response against GAD and consider how such information may help identify the disease mechanisms of these disorders.
Ellis
T M
TM
University of Florida, Department of Pathology and Laboratory Medicine College of Medicine, Gainesville 32610, USA.
Atkinson
M A
MA
D000818:Animals; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D016750:Stiff-Person Syndrome / Q000209:etiology / Q000276:immunology*
D005968:Glutamate Decarboxylase