Visual attention and perception in patients with Huntington's disease: comparisons with other subcortical and cortical dementias.
Shifts in attention were examined in patients with Huntington's disease (HD) using a divided attention paradigm that involved the presentation of global-local stimuli. The HD patients' pattern of performance was compared to the previously reported results of groups of patients with Alzheimer's disease (AD; Filoteo et al., 1992) or Parkinson's disease (PD; Filoteo et al., 1994). Across consecutive trials of the divided attention task, a visual target could appear at either the same global-local level or at a different level. When the target changed levels across consecutive trials, the AD patients demonstrated an impairment in disengaging attention from the level at which the last target appeared, whereas the PD patients were impaired in maintaining their attention at the previously attended level. In contrast to these patterns of performances, the HD patients did not demonstrate a significant impairment in shifting attention between hierarchical levels. Both the AD and the PD patients' abnormal shifting ability was significantly related to the number of errors they made in identifying target stimuli; however, the pattern of the relationship was qualitatively distinct. These results suggest that different attentional mechanisms may underlie AD and PD patients' visual-perceptual deficits. The HD patients' shifting ability was not related to the number of errors they made in identifying target stimuli, suggesting that a different mechanism may account for the visual-perceptual impairments exhibited by these patients.
Filoteo
J V
JV
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
Delis
D C
DC
Roman
M J
MJ
Demadura
T
T
Ford
E
E
Butters
N
N
Salmon
D P
DP
Paulsen
J
J
Shults
C W
CW
Swenson
M
M
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001288:Attention / Q000502:physiology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*