Tyrosine kinase-mediated signal transduction pathways and the actions of polypeptide growth factors and G-protein-coupled agonists in smooth muscle.
This synopsis focuses on the role that tyrosine kinase pathways may play in the acute regulation of smooth muscle contractility by receptor-kinase-activating growth factors, such as epidermal growth factor-urogastrone (EGF-URO) and by G-protein-coupled agonists, such as angiotensin-II. Growth factor-activated response paradigms that modulate smooth muscle contractility are summarized and the parallels between the actions of G-protein-coupled agonists and growth factors in these response systems are pointed out. A possible dynamic interplay between tyrosine kinase and tyrosine phosphatase activities to modulate tissue tension is also hypothesized. Finally, a model is proposed, wherein an intermediary tyrosine kinase pathway is suggested as a point of convergence for the regulation of smooth muscle contractility by agonists as diverse as EGF-URO and angiotensin-II.
Hollenberg
M D
MD
Department of Pharmacology & Therapeutics, University of Calgary, Faculty of Medicine, Alberta, Canada.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D008962:Models, Theoretical; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology*; D015398:Signal Transduction; D013552:Swine; D014638:Vanadates / Q000494:pharmacology; D014661:Vasoconstriction
D004791:Enzyme Inhibitors; D006133:Growth Substances; D017978:Receptors, Growth Factor; C076715:pervanadate; D000804:Angiotensin II; D014638:Vanadates; D004815:Epidermal Growth Factor; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D002118:Calcium