title: An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
abstract: An increasingly large number of proteins involved in signal transduction have been identified in recent years and shown to control different steps of cell survival, proliferation, and differentiation. Among the genes recently identified at the tip of the long arm of the human X chromosome, a novel gene, C1, encodes a protein that appears to represent a newly discovered member of the group of signaling proteins involved in regulation of the small GTP binding proteins of the ras superfamily. The protein encoded by C1, p115, is synthesized predominantly in cells of hematopoietic origin. It is characterized by two regions of similarity to motifs present in known proteins: GAP and SH3 homologous regions. Its localization in a narrow cytoplasmic region just below the plasma membrane and its inhibitory effect on stress fiber organization indicate that p115 may down regulate rho-like GTPases in hematopoietic cells.
authors.affiliation: Istituto di Genetica Biochimica ed Evoluzionistica, Consiglio Nazionale delle Ricerche, Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tribioli
authors.forename: S
authors.initials: S
authors.lastname: Droetto
authors.forename: S
authors.initials: S
authors.lastname: Bione
authors.forename: G
authors.initials: G
authors.lastname: Cesareni
authors.forename: M R
authors.initials: MR
authors.lastname: Torrisi
authors.forename: L V
authors.initials: LV
authors.lastname: Lotti
authors.forename: L
authors.initials: L
authors.lastname: Lanfrancone
authors.forename: D
authors.initials: D
authors.lastname: Toniolo
authors.forename: P
authors.initials: P
authors.lastname: Pelicci
mesh_terms: D000199:Actins / Q000302:isolation & purification; D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002451:Cell Compartmentation; D018076:DNA, Complementary / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D020690:GTPase-Activating Proteins; D015723:Gene Library; D008040:Genetic Linkage; D006412:Hematopoietic Stem Cells / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014960:X Chromosome / Q000235:genetics*; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D018909:src Homology Domains
chemical_list: C446101:ARHGAP4 protein, human; D000199:Actins; D018076:DNA, Complementary; D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; C085379:rho GTPase-activating protein; D019204:GTP-Binding Proteins; D018631:ras Proteins