title: [Relationship between chronic liver diseases and hepatitis C in Burundi adults].
abstract: A case/control study was conducted in Bujumbura, Burundi, from 1991 to 1992 to assess the relationship between chronic liver disease and hepatitis C virus (HCV). Patients presenting chronic liver disease (n = 80) were selected based on clinical, laboratory, ultrasonographic, and/or endoscopic findings. Patients with AIDS or hepatocellular carcinoma were excluded. Controls (n = 159) matched with regard to age and sex were recruited from outpatients who had blood tests at a liver disease clinic. Patients and controls were tested for anti-HCV antibodies by ELISA and LIA. Screening for hepatitis B virus (HBs antigen, anti-HBs and anti-HBc antibodies) and human immunodeficiency virus (HIV) was achieved by ELISA with confirmation of HIV infection by LIA. The incidence of anti-HCV antibodies was significantly higher in patients (55.0%) than controls (33.3%) (p < 0.001). The incidence of HBs antigens was significantly higher in patients (28.8%) than controls (7.5%) (p < 0.0001). The incidence of anti-HIV antibodies was not significantly different in the two groups. Multifactorial analysis indicated that anti-HCV antibodies and HBs antigens were risk factors for chronic liver disease, but did not detected a significant interaction between these two risk factors. Prevention of hepatitis C and B would reduce the incidence of chronic liver disease but cost currently limits widespread use of this approach.
authors.affiliation: Département de Médecine Interne, Centre Hospitalier Universitaire Kamenge, Bujumbura, Burundi.
authors.forename: P
authors.initials: P
authors.lastname: Aubry
authors.forename: B
authors.initials: B
authors.lastname: Larouze
authors.forename: G
authors.initials: G
authors.lastname: Muhirwa
authors.forename: D
authors.initials: D
authors.lastname: Henzel
authors.forename: E
authors.initials: E
authors.lastname: Ndabaneze
authors.forename: J M
authors.initials: JM
authors.lastname: Nsabimana
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002063:Burundi; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D015994:Incidence; D008107:Liver Diseases / Q000276:immunology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016036:Seroepidemiologic Studies; D014504:Urban Health
chemical_list: D018937:Hepatitis C Antibodies
vernacular_title: Relations entre maladies hépatiques chroniques et virus de l'hépatite C chez des adultes burundais.