Effect of calcium and 1,25 dihydroxyvitamin D on the level of parathyroid hormone in patients with secondary hyperparathyroidism due to chronic renal insufficiency.
Thirty-two patients with chronic renal insufficiency on the heamodialys were studied. Serum calcium significantly correlated with mPTH/iPTH ratio (p < 0.01). The rise in concentrations of calcium during calcium infusion significantly increased mPTH/iPTH ratio (p < 0.05). Concentrations of iPTH declined for more than 50% in 65% patients during calcium infusion. Secretion of PTH was not suppressed in two patients. Serum PTH values were lower in group of patients who received 1,25 dihydroxyvitamin D (p < 0.05). Serum calcium values were similar in these investigated groups. Suppression of PTH secretion with calcium rose in group of patients who received 1,25 dihydroxyvitamin D for two years. Suppression of PTH with calcium declined in two of three investigated patients who did not receive 1,25 dihydroxyvitamin D for two years.
Vucković
S
S
Service of Nuclear Medicine, Medical Centre, Zajecar.
Paunković
N
N
D002118:Calcium / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000494:pharmacology
D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium