Endogenous nitric oxide is not involved in acute parathyroid hormone-induced hypotension in rat: effect of hypertension and hypoparathyroid status.
The present study investigated the acute hypotensive effect of parathyroid hormone (PTH) in anesthetized adult spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats. Furthermore, in order to determine the possible contribution of nitric oxide (NO), a mediator of endothelium-dependent vasorelaxation, hypotensive responses to PTH were obtained in the presence of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthesis. The hypotensive effect of PTH (expressed as % of baseline blood pressure) was similar for the two strains. In the presence of L-NAME (18.5 mumol/kg), both strains demonstrated a similar hypotensive response to PTH, indicating that the hypotensive response to PTH is NO-independent.
Schleiffer
R
R
CNRS URA 600, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France.
Pernot
F
F
Gairard
A
A
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000097:blood; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D007011:Hypoparathyroidism / Q000503:physiopathology*; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010281:Parathyroid Hormone / Q000494:pharmacology*; D016105:Parathyroidectomy; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D004791:Enzyme Inhibitors; D010281:Parathyroid Hormone; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D002118:Calcium; D019331:NG-Nitroarginine Methyl Ester