title: Canine pulmonary hypertension model induced by pulmonary artery embolization of gelatin sponges.
abstract: We attempted to develop a pulmonary hypertension model in dogs by gelatin sponge embolization. We then monitored right-ventricular pressure overload by echocardiography. Gelatin sponges (Spongel, Yamanouchi, Tokyo) were homogenized and mixed in normal saline (0.6 mg/ml). The mixture was administered via the jugular vein to general pulmonary emboli. Repeated administration of the sponges increased the mean pulmonary arterial pressure and caused right ventricular pressure overload. The degree of pulmonary hypertension was proportional to the volume of gelatin sponge injected. Echocardiography, performed both before and after embolization, proved useful assessing for the degree of right-ventricular pressure overload.
authors.affiliation: First Department of Surgery, Nagasaki University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Kawahara
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Tagawa
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Muraoka
authors.forename: M
authors.initials: M
authors.lastname: Tomita
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004452:Echocardiography; D005780:Gelatin; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000503:physiopathology; D011655:Pulmonary Embolism / Q000209:etiology*; D011669:Pulmonary Wedge Pressure
chemical_list: D005780:Gelatin