title: Determination of tissue polypeptide-specific antigen in pleural fluid and serum from patients with pleural effusion.
abstract: As a tool for differentiating malignant and benign pleural effusions, we evaluated the diagnostic value of the assay of tissue polypeptide-specific antigen (TPS) in pleural fluid and serum, and of the pleural fluid TPS/serum TPS ratio in patients with pleural effusion. We studied prospectively 147 consecutive patients who had pleural effusions: 43 malignant pleural effusions and 104 benign pleural effusions. TPS levels were measured by RIA. The sensitivity and specificity of these measurements were: TPS in pleural fluid (cutoff 20,000 U/L): 0.21 and 0.98; TPS in serum (cutoff 300 U/L); 0.31 and 0.96; pleural fluid TPS/serum TPS ratio (cutoff 1200): 0.07 and 0.99. All these values enhanced the sensitivity of cytologic analysis of pleural fluid. However, we conclude that TPS assay in pleural fluid and serum, and the pleural fluid TPS/serum TPS ratio have limited diagnostic value in patients with pleural effusion.
authors.affiliation: Department of Lung Diseases, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Villena
authors.forename: J
authors.initials: J
authors.lastname: Echave-Sustaeta
authors.forename: A
authors.initials: A
authors.lastname: Lopez-Encuentra
authors.forename: P
authors.initials: P
authors.lastname: Martin-Escribano
authors.forename: J
authors.initials: J
authors.lastname: Estenoz-Alfaro
authors.forename: B
authors.initials: B
authors.lastname: Ortuño-de-Solo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000378:metabolism*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood* / Q000378:metabolism*; D010996:Pleural Effusion / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism*; D016066:Pleural Effusion, Malignant / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism*; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D019396:Tissue Polypeptide Antigen
chemical_list: D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen