Characterization of monascidin A from Monascus as citrinin.
Following our investigations on red pigments and monascidin co-production by Monascus species, the antibiotic called monascidin A was characterized as citrinin. Evidence was given by qualitative methods, mass spectra and NMR. Citrinin, a nephrotoxic agent was produced both by Monascus purpureus and Monascus ruber, either in submerged culture of concentrations of 270 and 340 mg/l, respectively, or in solid state culture of concentration of 100 and 300 mg/kg dried matter, respectively. Since citrinin is a toxic product, it is essential that the production of red pigments as food additives from Monascus spp. avoid the occurrence of citrinin.
Blanc
P J
PJ
Département Génie Biochimique et Alimentaire, UA-CNRS N. 544, Institut National des Sciences Appliquées, Complexe Scientifique de Rangueil, Toulouse, France.
Laussac
J P
JP
Le Bars
J
J
Le Bars
P
P
Loret
M O
MO
Pareilleux
A
A
Prome
D
D
Prome
J C
JC
Santerre
A L
AL
Goma
G
G
D001419:Bacteria / Q000187:drug effects*; D002953:Citrinin / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D005656:Fungal Proteins / Q000096:biosynthesis* / Q000494:pharmacology; D005658:Fungi / Q000378:metabolism*; D010860:Pigments, Biological
D005656:Fungal Proteins; D010860:Pigments, Biological; D002953:Citrinin