Molecular biology and cytogenetics of non-Hodgkin's lymphoma in children.
Molecular analysis, combined with cytogenetic studies of proto-oncogenes and tumor suppressor genes, has provided insight into the pathogenesis of non-Hodgkin's lymphoma. Characterization of these malignancies at the molecular level will aid in developing more sensitive detection methods for earlier and more accurate diagnosis. Thus, genetic rearrangements provide highly specific molecular markers for monitoring malignant cells. Additionally, a more detailed understanding of the precise, molecular steps leading to malignant transformation will facilitate the development of more specific and, perhaps, less toxic therapies.
Williams
S A
SA
Division of Hematology/Oncology and Blood and Bone Marrow Transplantation, Children's Hospital of Orange County, CA 92668, USA.
Suen
Y
Y
Cairo
M S
MS
D015139:Blotting, Southern; D002648:Child; D002869:Chromosome Aberrations; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000235:genetics*; D016133:Polymerase Chain Reaction