Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene (GUSB) to 7q11.21 --> q11.22 and two pseudogenes to 5p13 and 5q13.
The gene coding for human beta-glucuronidase (GUSB) was mapped to 7q11.21 --> q11.22 by fluorescence in situ hybridization (FISH), thus clarifying the contradictory published localizations of this gene. Multiple unprocessed pseudogenes and pseudogene fragments for GUSB have been described. However, only two weak signals, one at chromosome band 5p13 and the other at 5q13, could be detected with FISH, suggesting considerable divergence between GUSB and its related sequences.
Speleman
F
F
Department of Medical Genetics, University Hospital Ghent, Belgium.
Vervoort
R
R
van Roy
N
N
Liebaers
I
I
Sly
W S
WS
Lissens
W
W
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D011544:Pseudogenes
D005966:Glucuronidase