Bleomycin and FK 565 enhance the release of GM-CSF from LPS-stimulated BALB/c peritoneal macrophages.
The anti-tumour antibiotic Bleomycin, the experimental immunostimulatory tripeptide FK 565, and the immunosuppressive agent Cyclosporin A were examined for their in vitro effects on the release of the haemopoietic cytokine Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) from LPS stimulated BALB/c adherent peritoneal macrophages. FK 565 and Bleomycin produced an increase in GM-CSF release indicating that these agents are capable of stimulating peritoneal macrophage populations. Cyclosporin A was found to have no effect.
Blaney
B A
BA
Immunology Department, Strathclyde University, Glasgow.
Turk
J L
JL
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009842:Oligopeptides / Q000494:pharmacology*
D008070:Lipopolysaccharides; D009842:Oligopeptides; D001761:Bleomycin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D016572:Cyclosporine; C039537:heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine