title: Apoptosis of neurons in the vestibular nuclei of adult mice results from prolonged change in the external environment.
abstract: Pharmacological manipulations which result in abnormal levels of excitatory amino acid (EAA) mediated neurotransmission can result in neuronal apoptosis. We accordingly hypothesised that manipulations of the external environment which induce prolonged EAA-mediated transmission in sensory neurons may also induce apoptosis. This hypothesis was tested by placing groups of adult mice, housed in their home cage, on a turntable which slowly rotated (0.8 rev./min). This non-invasive manipulation will have resulted in abnormal discharge patterns in the vestibular nuclei. Significantly greater levels of neuronal apoptosis were seen in the vestibular complex after rotation for 48 h compared with non-rotated controls. This finding was also predicted independently from a computational approach.
authors.affiliation: School of Psychology, University of Birmingham, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Mitchell
authors.forename: A J
authors.initials: AJ
authors.lastname: Cooper
authors.forename: G D
authors.initials: GD
authors.lastname: Brown
authors.forename: C M
authors.initials: CM
authors.lastname: Waters
mesh_terms: D000818:Animals; D017209:Apoptosis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000473:pathology / Q000502:physiology; D012399:Rotation; D013194:Staining and Labeling; D014726:Vestibular Nuclei / Q000473:pathology / Q000502:physiology*