A case of ovarian carcinoma with production of granulocyte colony-stimulating factor.
A 60-year-old female with ovarian carcinoma showed marked leucocytosis. After exploratory laparotomy she had received carboplatin-based chemotherapy, but she died of respiratory failure. In this case the immunohistochemical examination of the tumour cells showed partial-positive staining for anti-G-CSF monoclonal antibody in addition to the elevation of the serum G-CSF concentration. This case is the first report of an ovarian carcinoma producing G-CSF.
Sudo
S
S
Department of Obstetrics and Gynaecology, Obihiro Kousei Hospital, Hokkaido, Japan.
Yamada
H
H
Kikuchi
K
K
Sumie
A
A
Yamashita
Y
Y
Tumura
N
N
Kawaguchi
I
I
Fujimoto
S
S
Kato
A
A
Yamaguchi
J
J
D000230:Adenocarcinoma / Q000378:metabolism*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007964:Leukocytosis / Q000378:metabolism; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism*
D016179:Granulocyte Colony-Stimulating Factor