Effect of interferon alpha IIb on the activity of sialyltransferase in testis homogenates of adult rats.
Interferon alpha IIb was injected to adult male rats at doses ranging from 10,000 to 200,000 units. Animals were dissected at intervals of 12 h, 24 h, and 5 days. The activity of the enzyme sialyltransferase in testis homogenates was estimated. In the majority of experiments enzyme activity decreased in comparison to controls.
Singer
R
R
Male Fertility Laboratory, Beilinson Medical Center, Petah Tikva, Israel.
Cohen
A
A
Levinsky
H
H
Raanani
P
P
Luria
B B
BB
Weissenberg
R
R
Lahav
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D012799:Sialyltransferases / Q000187:drug effects / Q000378:metabolism*; D013737:Testis / Q000201:enzymology*; D013997:Time Factors
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012799:Sialyltransferases