Course of pregnancy, steroid hormone levels and maturation process of placentomes after oestrone infusion in cows near term.
The present study was designed to examine the effect of systemic oestrone infusion on the course of late pregnancy and parturition, steroid hormone concentrations and maturation of placentomes in cows. Twelve pluriparous pregnant cows with known breeding dates were used in this experiment. Starting on day 267 of pregnancy six cows (experimental group) received 20 mg oestrone daily (in four doses) infused into the vena jugularis until parturition. Six other cows infused with vehicle served as control. Concentrations of oestrone (E1), oestrone sulphate (E1S) and progesterone (P4) were measured by RIA, and after parturition placentomes were examined histologically. In experimental and control animals parturition occurred on days 276,9 +/- 1.8 and 277,2 +/- 1.1 of gestation, respectively. The concentrations of E1 in the treated group were higher (8-12 ng/ml) than those in control animals (1-3 ng/ml), while the levels of E1S (8-14 ng/ml) were similar for both groups. The concentrations of P4 in experimental and control cows were typical for late pregnancy (4-6 ng/ml), with a sharp drop of this hormone 1-2 days before calving. The histological pictures of placentomes obtained from both groups of animals were similar and maturation of the placenta was observed. These results suggest that the prepartal increase of oestrone in maternal plasma does not play a major role in the regulation of parturition and placental maturation.
Janowski
T
T
Division of Clinical Endocrinology, Faculty of Veterinary Medicine, University of Agriculture and Technology, Olsztyn, Poland.
Zduńczyk
S
S
Podhalicz-Dziegielewska
M
M
Raś
A
A
Chmielewski
A
A
D000818:Animals; D002417:Cattle / Q000097:blood / Q000502:physiology*; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood* / Q000494:pharmacology*; D005260:Female; D007262:Infusions, Intravenous / Q000662:veterinary; D007743:Labor, Obstetric / Q000097:blood / Q000187:drug effects / Q000502:physiology; D010920:Placenta / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000097:blood*
D004970:Estrone; D011374:Progesterone; C017296:estrone sulfate