Genetic and biochemical factors associated with variation in blood pressure in a genetic isolate.
We previously found an association between blood pressure and genetic variation of angiotensinogen in Canadian Hutterites. We hypothesized that variation in other candidate genes would also be associated with variation in blood pressure. We included genotypes of 12 candidate genes, along with clinical features and biochemical variables as covariates in an association analysis. We found that sex and body mass were significantly associated with variation in both systolic and diastolic blood pressures. We found that genotypes of APOB codon 4154 and AGT codon 174 were significantly associated with variation in systolic blood pressure. We found that genotypes of APOB codon 4154, AGT codon 174, and F7 codon 353 were significantly associated with variation in diastolic blood pressure. We found a significant association between age and variation in systolic but not diastolic blood pressure. We found a significant association between plasma apo B concentration and variation in diastolic but not systolic blood pressure. The association of genomic variation with resting blood pressure is consistent with the existence of important structural elements within or proximal to some genes in lipoprotein metabolism, the renin-angiotensin system, and the coagulation cascade. The association between plasma apo B concentration and diastolic blood pressure suggests that these traits may share some determinants.
Hegele
R A
RA
Department of Medicine, St Michael's Hospital, University of Toronto, Ontario, Canada. robert.hegele@utoronto.ca
Brunt
J H
JH
Connelly
P W
PW
D000808:Angiotensinogen / Q000235:genetics; D001055:Apolipoproteins B / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics*; D002170:Canada; D002835:Christianity; D003062:Codon; D003327:Coronary Disease / Q000453:epidemiology; D005006:Ethnicity / Q000235:genetics*; D005819:Genetic Markers; D014644:Genetic Variation; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008074:Lipoproteins / Q000235:genetics; D015995:Prevalence; D012084:Renin-Angiotensin System / Q000235:genetics; D012307:Risk Factors; D014481:United States
D001055:Apolipoproteins B; D003062:Codon; D005819:Genetic Markers; D008074:Lipoproteins; D000808:Angiotensinogen