[Effect of the phytogenic secretolytic drug Gelomyrtol forte on mucociliary clearance of the maxillary sinus].
BACKGROUND
To date, there has not been sufficient experimental evidence to demonstrate the pharmacological effect of secretolytic and mucolytic drugs.


METHODS
Scintigraphic studies to detect the mucociliary clearance in the maxillary sinus before and after application of the secretolytic drug Gelomyrtol forte were performed on four healthy persons and one patient after sinus surgery. The most important parameter was the mucociliary transport velocity of the "region of interest-maxillary sinus" and the increase of radioactivity accumulated in a tampon placed in the middle meatus of the nose. Measurements were done with a gamma-camera, 99 m Technetium-sulphurcolloid was used as the radiopharmacentical. A dose of 1 MBq in 0.2 ml NaCl-solution was injected into the maxillary sinus.


RESULTS
The results show a clear increase of mucociliary transport velocity in the maxillary sinus after intake of secretolytics in connection with an increase of radioactivity in the tampon.


CONCLUSIONS
The results can be explained by the secretolytic and secretomotoric effects of the investigated drug.


CONCLUSIONS
The study reveals that ethereal oils have secretolytic effects and also have a pharmacological effect on the mucociliary apparatus.
Behrbohm
H
H
Krankenhaus Berlin-Weissensee, HNO-Klinik.
Kaschke
O
O
Sydow
K
K
D000328:Adult; D004338:Drug Combinations; D005100:Expectorants / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000187:drug effects*; D008610:Menthol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D011877:Radionuclide Imaging; D012016:Reference Values; D013671:Technetium Tc 99m Sulfur Colloid; D013729:Terpenes / Q000494:pharmacology*
D004338:Drug Combinations; D005100:Expectorants; D013729:Terpenes; C016469:gelomyrtol; D008610:Menthol; D013671:Technetium Tc 99m Sulfur Colloid
Der Einfluss des pflanzlichen Sekretolytikums Gelomyrtol forte auf die mukoziliäre Clearance der Kieferhöhle.