Expression of proliferating cell nuclear antigen in basal cell carcinomas and in squamous cell carcinomas of canine skin: correlation with mitotic index and histological features.
In this study we evaluated the behaviour of proliferating cell nuclear antigen labelling index (PCNA-LI), mitotic index (MI) and histological features in ten basal cell carcinomas (BCC) and ten squamous cell carcinomas (SCC) of canine skin. PCNA-LI ranged from 2.1% to 4.8% in SCC and from 0.1% to 2.0% in BCC samples. A significant statistical correlation, between PCNA-LI and MI could be demonstrated only in SCC, but not in BCC samples. Furthermore, PCNA-LI was also significantly and consistently greater in the three BCC of solid type and in poorly differentiated SCC. PCNA-LI may provide additional criterion in evaluating the intrinsic malignancy and growth potential of the above tumours.
Maiolino
P
P
Dipartimento di Patologia, Profilassi e di Ispezione degli Alimenti, Facoltà di Medicina Veterinaria, Università degli studi di Napoli Federico II, Italy.
Restucci
B
B
De Vico
G
G
D000818:Animals; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D008940:Mitotic Index; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis* / Q000378:metabolism; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*
D018809:Proliferating Cell Nuclear Antigen