title: The trophic action of human growth hormone on human duodenal mucosa cultured in vitro.
abstract: The influence of human growth hormone (hGH) on crypt cell proliferation in cultured explants of human duodenal mucosa has been studied, using a stathmokinetic technique with crypt microdissection. The addition of hGH (0.004 IU/ml) to paired duodenal explants from eight patients significantly increased epithelial crypt cell proliferation (p < 0.001), showing that hGH has a trophic action on the human duodenal mucosa in vitro.
authors.affiliation: Somerset Children's Research Unit, Musgrove Park Hospital, Taunton, England.
authors.forename: D N
authors.initials: DN
authors.lastname: Challacombe
authors.forename: E E
authors.initials: EE
authors.lastname: Wheeler
mesh_terms: D000368:Aged; D001706:Biopsy; D002455:Cell Division / Q000187:drug effects; D046508:Culture Techniques; D004386:Duodenum / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged
chemical_list: D013006:Growth Hormone