The transfer of polystyrene microspheres from the gastrointestinal tract to the circulation after oral administration in the rat.
Factors relating to the transfer of latex microspheres of 0.87 micron mean diameter from the gastrointestinal tract (GIT) to the circulation have been investigated. The rapidity of appearance and the number of particles increased when the volume of water used as a suspending vehicle was increased. This was probably due to barrier cell integrity being compromised so that the movement of particles across the enterocytes would be enhanced. Particles were swept into these channels by the waterflow. The tonicity of the fluid was important as isotonic and hypertonic saline were not as effective as water in transferring particles. Particles were transferred from GIT segments adjacent to the stomach which may in part explain the rapid appearance of particles in the circulation. Particle uptake was blocked by cytochalasin B which suggests an active component may also be involved.
Eyles
J
J
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
Alpar
O
O
Field
W N
WN
Lewis
D A
DA
Keswick
M
M
D000284:Administration, Oral; D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology; D004064:Digestive System / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008863:Microspheres; D011137:Polystyrenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000737:chemistry / Q000378:metabolism
D011137:Polystyrenes; D012462:Saline Solution, Hypertonic; D003571:Cytochalasin B; C024075:styrofoam