Influence of combined AC-DC magnetic fields on free radicals in organized and biological systems. Development of a model and application of the radical pair mechanism to radicals in micelles.
The effect of an alternating current (AC) magnetic field (MF) on radical behavior is identical to that exerted by a direct current (DC) field of the same instantaneous strength provided that the frequency is low enough in comparison with radical pair dynamics. This criterion is easily met by environmental fields. In general, combined AC/DC fields will lead to increased radical concentrations and oscillating free radical concentrations. Interestingly, the frequency of oscillation for radical concentration seldom follows exactly the pattern of the external AC component of the MF. Even the simple case of an AC-only field at 60 Hz can lead to oscillations in radical concentrations at 120 Hz. The concentration time dependence patterns can be even more complex when the singlet and triplet levels of the radical pair are not degenerate. Further, the effects can change dramatically depending upon the absolute and relative values of the AC and DC components, thus providing a possible explanation for MF windows for certain effects reported experimentally. Effects on the average radical concentration are probably relevant only for fields higher than about 0.1 gauss. Oscillating radical concentrations may influence signal transduction processes or other cellular mechanisms; at the present time there is not enough knowledge available to establish a reasonable threshold for these types of effects. This contribution aims at providing a solid foundation to guide the experimentalist in the design of meaningful experiments on the possible role of MF perturbations of radical chemistry on biological response.
Scaiano
J C
JC
Department of Chemistry, University of Ottawa, Ontario, Canada.
Cozens
F L
FL
Mohtat
N
N
D001577:Benzophenones / Q000737:chemistry; D003510:Cyclohexanes / Q000737:chemistry; D053138:Cyclohexenes; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005609:Free Radicals; D008823:Micelles; D008954:Models, Biological; D008956:Models, Chemical; D015398:Signal Transduction
D001577:Benzophenones; D003510:Cyclohexanes; D053138:Cyclohexenes; D005609:Free Radicals; D008823:Micelles; C048401:1,4-cyclohexadiene; C047723:benzophenone