[Changes in myocardial ATPase activity and Ca2+ content in burned rats].
The myocardial ATPase activity and Ca2+ content were investigated in rats with full thickness skin burn injury of 30% TBSA. The results showed that there were significant inhibitions of Na+, K(+)-ATPase,Ca2+, Mg(2+)-ATPase, and Ca(2+)-ATPase activities of myocardium after burn injury. The burn injury could result in increase of calcium content in myocardium. Burned rats also had a higher level of MDA in heart tissue when compared to controls. This study demonstrates that the membrane defects with respect to ATPase activity, oxygen free radical, and Ca2+ overload in myocardium may be associated with damage of myocardium after burns.
Huan
J
J
Burn Institute, Changhai Hospital, Shanghai.
Chen
Y
Y
Ge
S
S
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D002056:Burns / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008315:Malondialdehyde; D000251:Adenosine Triphosphatases; D002118:Calcium