Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717.
A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2,5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC50 being 1.9 x 10(-4) M.
Kagamizono
T
T
Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd., Saitama, Japan.
Nishino
E
E
Matsumoto
K
K
Kawashima
A
A
Kishimoto
M
M
Sakai
N
N
He
B M
BM
Chen
Z X
ZX
Adachi
T
T
Morimoto
S
S
D000818:Animals; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D003904:Mitosporic Fungi / Q000378:metabolism* / Q000648:ultrastructure; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
D009025:Morpholines; D010975:Platelet Aggregation Inhibitors; C085610:lateritin