Influence of ethanol ingestion on tetracycline kinetics.
The effect of ethyl alcohol ingestion on tetracycline kinetics was studied in 9 healthy male volunteers. They received, on two separate occasions, 500 mg of tetracycline tablets given with water or with an alcoholic beverage. The antibiotic was assayed in plasma, using a HPLC method. Absorption and disposition parameters were calculated according to classical pharmacokinetic techniques for one compartment model. The significance of changes in pharmacokinetic parameters was determined by a multiway ANOVA test. In the present study, ingestion of alcohol caused significant increase of Cmax (from 9.317 to 12.362 micrograms/ml), and increase of AUC (from 62.65 to 94.28 micrograms/ml*h).
Seitz
C
C
Department of Pharmaceutical Science and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Garcia
P
P
Arancibia
A
A
D000042:Absorption; D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D000704:Analysis of Variance; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D006801:Humans; D008297:Male; D013752:Tetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D013752:Tetracycline