[Clinical research of muscular relaxation induced by alcuronium and pancuronium].
The clinical experiment was designed for observing effect of muscular relaxation induced by alcuronium and pancuronium. 40 patients were randomly divided into alcuronium group (A) and Pancuronium group (P). A group and P group were redivided into A1,A2 groups and P1,P2 groups according to differences of the initial doses of muscle relaxants. The results of neuromuscular monitoring indicate that onset time and main-tenance time of 0.3 mg/kg alcuronium were respectively 2.4 min and 63 min; 0.1 mg/kg pancuronium were 2.7 min and 70 min. The initial doses mentioned above are suitable to intubation of anesthesia and meet surgical need for muscular relaxation. The changes of MAP,HR,blood kalium and natrium were not evident in statistical significance before and after administration of relaxants.
Gong
Z
Z
PUMC Hospital, CAMS, Beijing.
Ye
T
T
Pei
L
L
Luo
X
X
Luo
A
A
D000443:Alcuronium / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D006801:Humans; D009126:Muscle Relaxation / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010197:Pancuronium / Q000008:administration & dosage / Q000494:pharmacology*
D003473:Neuromuscular Nondepolarizing Agents; D010197:Pancuronium; D000443:Alcuronium