title: Non-bleeding visible vessel treatment: perendoscopic injection therapy versus omeprazole infusion.
abstract: BACKGROUND
  The non-bleeding visible vessel in a peptic ulcer is the highest risk factor for a bleeding recurrence among not actively bleeding lesions. Perendoscopic injection of sclerosing compounds is usually used as prophylaxis against rebleeding.
  
  
  METHODS
  Forty-two patients with visible vessels in a peptic ulcer at an emergency endoscopic procedure have been studied: 21 patients underwent prophylactic perendoscopic hemostasis, and 21 patients were infused with omeprazole intravenously.
  
  
  RESULTS
  Eight patients (19%), four in each group, had early rebleedings (within 48 h after the enrollment). There was no significant difference between the two types of treatment. At the endoscopic control after 48 h there were significantly more lesions with higher risk of rebleeding (Forrest IIa and IIb) in the group treated with perendoscopic hemostasis.
  
  
  CONCLUSIONS
  Our data suggest that omeprazole infusion is a valid alternative to injection treatment of non-bleeding visible vessels.
authors.affiliation: Gastroenterology and Digestive Endoscopy Unit, Ca' Granda Niguarda Hospital, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Grosso
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: P
authors.initials: P
authors.lastname: Gambitta
authors.forename: M
authors.initials: M
authors.lastname: Bini
authors.forename: G
authors.initials: G
authors.lastname: Zanasi
authors.forename: Z
authors.initials: Z
authors.lastname: Pirone
authors.forename: R
authors.initials: R
authors.lastname: Arcidiacono
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016009:Chi-Square Distribution; D005260:Female; D005773:Gastroscopy; D016558:Hemostasis, Endoscopic; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage* / Q000627:therapeutic use; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy*; D013276:Stomach Ulcer / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole