Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria.
We examined the subcellular distribution of two glycogen synthase kinase-3 (GSK-3) isoforms in rat cerebellum. Results from immunoelectron microscopy and subcellular fractionation revealed that one isoform, tau protein kinase I/GSK-3 beta (TPKI/GSK-3 beta), was present in mitochondria, but GSK-3 alpha was not. Although the two GSK-3 isoforms seem to have similar properties, the difference of subcellular localization observed here suggests that TPKI/GSK-3 beta fulfills some specific function in mitochondria.
Hoshi
M
M
Mitsubishi Kasei Institute of Life Sciences, Tokyo.
Sato
M
M
Kondo
S
S
Takashima
A
A
Noguchi
K
K
Takahashi
M
M
Ishiguro
K
K
Imahori
K
K
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000032:analysis*; D002451:Cell Compartmentation; D002531:Cerebellum / Q000201:enzymology* / Q000648:ultrastructure; D038362:Glycogen Synthase Kinase 3; D038341:Glycogen Synthase Kinases; D016253:Microscopy, Immunoelectron; D008928:Mitochondria / Q000201:enzymology* / Q000648:ultrastructure; D017346:Protein Serine-Threonine Kinases / Q000032:analysis*; D051381:Rats
D038341:Glycogen Synthase Kinases; D017346:Protein Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3; C080888:tau-protein kinase