title: Metastasis to the optic nerve: clinicopathological correlations.
abstract: OBJECTIVE
  To describe the clinical, radiologic and histopathological features of two cases of carcinoma metastatic to the optic nerve with different pathways of spread.
  
  
  METHODS
  Chart review.
  
  
  METHODS
  Oncology clinic in Montreal.
  
  
  METHODS
  One patient previously treated for breast carcinoma and one patient previously treated for small-cell carcinoma of the lung.
  
  
  RESULTS
  The patient with breast carcinoma was found to have an elevated mass involving her right optic nerve head. This finding was confirmed by B-scan ultrasonography. The other patient initially presented with left retinal metastasis and subsequently manifested massive secondary involvement of the ipsilateral optic nerve, documented by computed tomography. Both patients were initially treated with radiotherapy to the eye and orbit, but postmortem histopathological study showed that this treatment had little effect on the tumour.
  
  
  CONCLUSIONS
  The histopathological observations suggest that if radiotherapy is to be used in the treatment of metastasis to the optic nerve, the dosage of radiation should be higher than that recommended for the treatment of choroidal metastasis.
authors.affiliation: Department of Pathology, Hôpital Notre-Dame, Montreal, PQ.
authors.forename: G S
authors.initials: GS
authors.lastname: Allaire
authors.forename: C
authors.initials: C
authors.lastname: Corriveau
authors.forename: J D
authors.initials: JD
authors.lastname: Arbour
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D002277:Carcinoma / Q000532:radiotherapy / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000532:radiotherapy / Q000556:secondary*; D003390:Cranial Nerve Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D008875:Middle Aged; D009900:Optic Nerve / Q000000981:diagnostic imaging / Q000473:pathology; D009901:Optic Nerve Diseases / Q000473:pathology* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography