title: Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?
abstract: In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that mitochondrially located nitric oxide synthase is a ubiquitous regulator of mitochondrial oxidative phosphorylation in mammalian cells is discussed.
authors.affiliation: Department of Neurochemistry, University of London, England.
authors.forename: T E
authors.initials: TE
authors.lastname: Bates
authors.forename: A
authors.initials: A
authors.lastname: Loesch
authors.forename: G
authors.initials: G
authors.lastname: Burnstock
authors.forename: J B
authors.initials: JB
authors.lastname: Clark
mesh_terms: D000818:Animals; D006706:Homeostasis; D007668:Kidney / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D008322:Mammals; D016253:Microscopy, Immunoelectron; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D008931:Mitochondria, Muscle / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019001:Nitric Oxide Synthase