Ethanol intake, plasma catecholamine levels, and ST-segment changes without myocardial injury in rats with short-term ethanol consumption.
The authors studied the effect of short-term ethanol consumption on the ST-segment and the association between ST-segment changes and the amount of daily ethanol intake and levels of plasma catecholamines. The study used 63 rats (control group n = 20, study group n = 43). The rats in the study group were exposed for 6 days to progressively larger doses of ethanol followed by 15 days of continuous exposure to ethanol. At baseline an electrocardiogram (ECG) was recorded, and on day 25 the ECG was repeated and plasma catecholamine levels were measured. The animals' hearts were removed and processed for histologic study. Repolarization abnormalities were observed in 68% of the ethanol-consuming rats. Two factors differentiated the subgroup of ethanol-consuming rats with ST-segment changes from the subgroup without ST-segment changes: amount of daily ethanol intake (0.0077 +/- 0.02 mL/g/d vs 0.0058 +/- 0.019 mL/g/d) and plasma epinephrine levels (3,881 +/- 733 pg/mL vs 1,478 +/- 406 pg/mL). No myocardial damage was detected. Our results suggest that in ethanol-consuming rats, high-volume daily ethanol intake and increased plasma catecholamines may mediate changes in the ST-segment.
Fantidis
P
P
Research-Experimental Surgery Unit, Hospital La Paz, Facultad de Medicina, Universidad Autónoma, Madrid, Spain.
Del Cerro
M J
MJ
Martínez
I
I
Rubio
G
G
Ruiz Villaespesa
A
A
Gamallo
C
C
Leon
G
G
Santodomingo
J
J
D000818:Animals; D004562:Electrocardiography / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood*; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000431:Ethanol; D009638:Norepinephrine; D004837:Epinephrine