title: Acquired factor VIII-specific antibody disorder accompanied by a life-threatening retroperitoneal hematoma.
abstract: A male patient, aged 58, without any discernible underlying disease developed a massive hemorrhage in the retroperitoneal cavity and in the femoral muscle. The hemorrhagic tendency of the patient was found to be due to the acquired anti-Factor VIII specific autoantibody in the blood. A concentrate of an activated prothrombin complex (FEIBA: Factor eight inhibitor bypassing activity) was administered and produced a remarkable effect in stemning the bleeding tendency of the patient. Immunosuppressive therapy was also effective for the control of the bleeding.
authors.affiliation: Department of Hematology, Nagoya National Hospital.
authors.forename: E
authors.initials: E
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Utsumi
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Tsushita
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahara
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Takamatsu
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D006406:Hematoma / Q000175:diagnosis / Q000209:etiology*; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000175:diagnosis / Q000209:etiology*; D012187:Retroperitoneal Space
chemical_list: D001323:Autoantibodies