title: No confirmation of Geschwind's hypothesis of associations between reading disability, immune disorders, and motor preference in ADHD.
abstract: Geschwind and colleagues have proposed an association among reading disability, immune disorder, and motor preference. Although reading disability commonly overlaps with attention deficit hyperactivity disorder (ADHD), ADHD has not been previously examined in studies evaluating Geschwind's hypothesis. In this paper we evaluate whether ADHD is associated with either asthma or left motor preference and whether asthma and left motor preference are associated with each other. Subjects were 6- to 17-year-old boys with DSM-III-R ADHD (n = 140) and normal controls (n = 120). Information on reading disability, asthma, and motor preference was obtained in a standardized manner blind to the proband's clinical status. Neither ADHD nor reading disability was associated with either asthma or left motor preference nor was asthma and left motor preference associated with one another. Our results are not consistent with Geschwind's hypothesis linking reading disability, immune disorder, and left motor preference.
authors.affiliation: Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: J
authors.initials: J
authors.lastname: Biederman
authors.forename: S
authors.initials: S
authors.lastname: Milberger
authors.forename: S V
authors.initials: SV
authors.lastname: Faraone
authors.forename: K A
authors.initials: KA
authors.lastname: Lapey
authors.forename: E D
authors.initials: ED
authors.lastname: Reed
authors.forename: L J
authors.initials: LJ
authors.lastname: Seidman
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D002648:Child; D015897:Comorbidity; D004410:Dyslexia / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D013739:Testosterone / Q000502:physiology
chemical_list: D013739:Testosterone