Diurnal variation in angiotensin sensitivity in pregnancy.
OBJECTIVE
Our purpose was to study the diurnal variation in angiotensin II sensitivity.


METHODS
Angiotensin sensitivity tests were performed at 9 AM and at 2 PM in 12 normotensive pregnant women, with each woman serving as her own control.


RESULTS
In all patients the effective pressor dose was higher in the afternoon.


CONCLUSIONS
We suggest the greater sensitivity to angiotensin in the morning is related to an intrinsic circadian variation in vascular reactivity. When the result of an angiotensin sensitivity test is interpreted, the time of day it is performed should be taken into account.
Delemarre
F M
FM
Department of Obstetrics and Gynecology, Catharina Hospital Eindhoven, The Netherlands.
Didden
M A
MA
de Jong
P A
PA
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000502:physiology*
D000804:Angiotensin II