Visible light anaerobic photoconversion of tyrosine sensitized by riboflavin. Cytotoxicity on mouse tumoral cells.
The anaerobic phototransformation of tyrosine under visible light sensitized by riboflavin is reported. The cytotoxicity of the anaerobic photoproducts on in vitro-cultured myeloid mouse tumoral cells was demonstrated. A radical mechanism is proposed. Dityrosine was identified as one of the main anaerobic photoproducts by using absorption, emission and 1H-NMR spectra.
Silva
E
E
Facultad de Química (536), P. Universidad Católica de Chile, Santiago, Chile.
Fürst
S
S
Edwards
A M
AM
Becker
M I
MI
De Ioannes
A E
AE
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D004347:Drug Interactions; D007951:Leukemia, Myeloid / Q000628:therapy*; D008027:Light; D051379:Mice; D010777:Photochemistry; D010789:Phototherapy; D012256:Riboflavin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D014443:Tyrosine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D014443:Tyrosine; D012256:Riboflavin