title: Regulation of tyrosine protein kinase receptor Trk-B and motor function in rats following cardiac arrest.
abstract: Following 10 min cardiac arrest and resuscitation, male Sprague-Dawley rats developed posthypoxic myoclonus. Sixty days later, the motor function of the animals was restored. In the present study, we investigated brain levels of tyrosine protein kinase receptor Trk-B with quantitative immunoblot analysis at various time points following cardiac arrest. In the frontal cortex, a significant reduction of Trk-B was found in rats 3 days (53%) after cardiac arrest, whereas significant increases were detected in rats 14 (124%) and an average 60 days (98%) after cardiac arrest. In the striatum, significant increases were found in rats 3 (389%), 14 (483%), and 60 days (521%) after resuscitation. In contrast, significant reductions of Trk-B were detected in the cerebellum of rats 3 (46%), 14 (22%), and 60 days (18%) after cardiac arrest. The results indicate that regulation of Trk-B may vary in different brain regions and have important roles in recovery processes following hypoxic-ischemic insults to the brain.
authors.affiliation: Department of Neurology, University of California Irvine 92717, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Jaw
authors.forename: D D
authors.initials: DD
authors.lastname: Su
authors.forename: Q V
authors.initials: QV
authors.lastname: Vuong
authors.forename: D D
authors.initials: DD
authors.lastname: Truong
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D006323:Heart Arrest / Q000378:metabolism* / Q000523:psychology*; D007091:Image Processing, Computer-Assisted; D015151:Immunoblotting; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009207:Myoclonus / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*
chemical_list: D020794:Receptor Protein-Tyrosine Kinases