title: Production of interleukin-5 and the suppressive effect of cyclosporin A in childhood severe atopic dermatitis.
abstract: A child with severe atopic dermatitis had marked improvement with oral cyclosporin A (CyA) therapy. The function of activated T lymphocytes and serum interleukin-5 concentrations were reduced. The expression and production of interleukin-5 were high, but were suppressed during CyA therapy and by CyA in vitro. Oral CyA therapy may be useful for severe atopic dermatitis.
authors.affiliation: Division of Pediatrics, Saga Prefectural Hospital Koseikan, Saga, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Hamasaki
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
mesh_terms: D002675:Child, Preschool; D016572:Cyclosporine / Q000494:pharmacology* / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D015848:Interleukin-5 / Q000096:biosynthesis / Q000097:blood*; D008297:Male
chemical_list: D016207:Cytokines; D015848:Interleukin-5; D016572:Cyclosporine