[The behavior of the activation parameters of plasma coagulation under HDR-afterloading therapy in patients with endometrial carcinoma].
BACKGROUND
In the radium era heparin prophylaxis was necessary to avoid thromboembolic events. Today with high-dose-rate (HDR) afterloading thromboembolic events are rare. Coagulation activation parameters were monitored during HDR afterloading to evaluate the necessity of heparin prophylaxis.


METHODS
Twenty patients with uterine carcinoma and no postoperative tumor residuals were randomized before their first 10 Gy OD HDR-afterloading application. Ten patients received heparin prophylaxis, the other ten patients received no prophylaxis. Blood samples were taken before, immediately after, 6 and 24 hours after HDR afterloading. D-Dimer, TAT, and F 1 + 2 were measured.


RESULTS
No significant activation of the coagulation system was observed over the investigated time period and no differences have been detected between both groups. None of the patients of either group developed thromboembolic complications.


CONCLUSIONS
HDR afterloading has no direct influence on the plasmatic coagulation system. From this point of view heparin prophylaxis does not seem necessary.
Münstedt
K
K
Abteilung für gynäkologische Onkologie und Strahlentherapie, Frauenklinik, Justus-Liebig-Universität Giessen.
Kemkes-Matthes
B
B
Matthes
K J
KJ
Vahrson
H
H
D000368:Aged; D001777:Blood Coagulation / Q000528:radiation effects*; D001780:Blood Coagulation Tests; D001918:Brachytherapy; D016889:Endometrial Neoplasms / Q000097:blood* / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage; D010949:Plasma / Q000528:radiation effects*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D014621:Vagina
D007496:Iridium Radioisotopes
Verhalten der Aktivierungsparameter der plasmatischen Gerinnung unter HDR-Afterloading-Therapie bei Patientinnen mit Endometriumkarzinom.