Can total artificial heart animals control their TAH by themselves? One year survival of a TAH goat using a new automatic control method (1/R control).
A total artificial heart (TAH) goat survived for 360 days on the new automatic control method (1/R control), in which the cardiac output of the TAH can be controlled through the cardiovascular center by making it function by reflecting the beta-adrenergic reaction in peripheral vascular resistance. This is thought to be the only long-term, real-time, measurable parameter by which information on the activity of the cardiovascular center can be received directly by the TAH system. In this goat, the hemodynamic parameters (RAP, AoP, and so forth) were kept within physiologic limits when control was stable, and the cardiac output was automatically increased in response to exercise, not unlike that in the natural heart. There were no abnormal blood chemical or hormone data except at end stage. Based on these results 1/R can be considered a physiologic control method for a TAH.
Abe
Y
Y
Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.
Chinzei
T
T
Imachi
K
K
Mabuchi
K
K
Imanishi
K
K
Isoyama
T
T
Matsuura
H
H
Senih
G
G
Nozawa
H
H
Kouno
A
A
D000818:Animals; D001698:Biomedical Engineering; D002302:Cardiac Output; D005260:Female; D006041:Goats; D006354:Heart, Artificial / Q000009:adverse effects; D006400:Hematocrit; D006439:Hemodynamics; D011655:Pulmonary Embolism / Q000209:etiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors; D014655:Vascular Resistance
D011943:Receptors, Adrenergic, beta