The mystery of Alzheimer's disease and its prevention by melatonin.
Preliminary observation suggested that a melatonin deficiency could cause Alzheimer's disease. New evidence reveals that: 1) a significant melatonin deficiency is common in the disease, 2) melatonin acts as a hydroxyl radical scavenger and 3) brain tissue mitochondria from Alzheimer's patients have damage consistent with hydroxyl radical injury.
Maurizi
C P
CP
Department of Pathology, Houston Medical Center, Warner Robins, Georgia 31093, USA.
D000544:Alzheimer Disease / Q000209:etiology* / Q000517:prevention & control; D003574:Cytochrome c Group / Q000172:deficiency; D016166:Free Radical Scavengers; D006801:Humans; D017665:Hydroxyl Radical; D008550:Melatonin / Q000172:deficiency* / Q000502:physiology / Q000627:therapeutic use; D008928:Mitochondria / Q000201:enzymology; D008954:Models, Biological
D003574:Cytochrome c Group; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D008550:Melatonin