Complete remission of metastatic breast cancer by non-specific immunostimulation with a Nocardia opaca cell-wall extract after failure of conventional therapy.
In a male patient with recurring lung metastases of infiltrating breast carcinoma (T2NOMO), primary treatment mastectomy, axillar dissection and local irradiation) the tumor metastases developed progressively despite of repeated surgical removement, polychemotherapy, and antiestrogen treatment. Active unspecific immunotherapy with a Nocardia opaca cell-wall extract, started in the final stage of the disease with deterioration of the performance status, resulted within several months in a complete remission without serious side effects. The reported result suggest that is is worth while to try such bacterial immunomodulators in therapy of advanced cancer in spite of many disappointing clinical trials.
Ehrenfeld
U
U
Jomol Pharma GmbH, Regensburg (FRG).
Haas
R
R
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D018567:Breast Neoplasms, Male / Q000473:pathology*; D002457:Cell Extracts; D006801:Humans; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009615:Nocardia
D000276:Adjuvants, Immunologic; D002457:Cell Extracts