title: Immune response to influenza vaccination in children with renal disease.
abstract: Although immunization with influenza vaccine is recommended for children with chronic renal disease and after organ transplantation, the antibody response in these children has not been well described. We studied the response to the 1993-1994 trivalent influenza vaccine in children, aged 1-21 years, with chronic renal failure (n = 15), end-stage renal disease requiring dialysis (n = 10), and post renal transplantation (n = 17). Each group's antibody response was compared with that of a control group (n = 7). No significant differences were found in seroconversion rates, percentage of patients achieving protective hemagglutination-inhibition titers post vaccination or change in geometric mean titers from pre to post vaccination between study groups and controls. These results suggest that pediatric patients with renal disease will respond and therefore will benefit from currently recommended influenza immunization.
authors.affiliation: Division of Pediatric Nephrology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Furth
authors.forename: A M
authors.initials: AM
authors.lastname: Neu
authors.forename: S A
authors.initials: SA
authors.lastname: McColley
authors.forename: B
authors.initials: B
authors.lastname: Case
authors.forename: M
authors.initials: M
authors.lastname: Steinhoff
authors.forename: B
authors.initials: B
authors.lastname: Fivush
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000276:immunology* / Q000628:therapy; D008297:Male; D017582:Renal Replacement Therapy; D012189:Retrospective Studies
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines