Are bacterial proteinases pathogenic factors?
Evidence is rapidly accumulating that suggests that the growth and proliferation of pathogenic bacteria depend on proteolytic enzymes of the invading organism and of the host. Proteinase inhibitors targeting bacterial proteinases may be useful antimicrobial agents.
Travis
J
J
Dept of Biochemistry, University of Georgia, Athens 30602, USA.
Potempa
J
J
Maeda
H
H
D000818:Animals; D001419:Bacteria / Q000201:enzymology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001426:Bacterial Proteins / Q000187:drug effects / Q000502:physiology*; D010450:Endopeptidases / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D007705:Kinins / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use; D014774:Virulence
D001426:Bacterial Proteins; D007705:Kinins; D011480:Protease Inhibitors; D010450:Endopeptidases; D007610:Kallikreins