title: [Subacute thrombosis of the abdominal aorta with suprarenal involvement and successful treatment with pharmacomechanical fibrinolysis].
abstract: In a 43-year-old patient with Ebstein's anomaly and a history of acute myocardial infarction by means of duplex ultrasonography and aortography the diagnosis of thrombotic occlusion of the a aorta was established, starting above the insertion of the renal arteries and reaching as far as the bifurcation of the aorta and the common iliac arteries. In the clinical picture dominated complete anuria with uraemia and marked hyperkaliaemia as a result of ischaemic affection of the extremities due to thrombosis of the aorta; at the onset of hospitalization also left ventricular failure with hyperhydration and later also signs of the hyperviscous syndrome. The latter developed after repeated haemofiltrations which led to a rise of the originally high haemoglobin and haemotocrit values a result of a righ-left shunt in Ebstein's anomaly. After improvement of the clinical condition local fibrinolytic treatment of the aortal thrombosis with urokinase (total dose 2,160,000 u. administered within 24 hours) was provided. The thrombus with a total length of 13.5 cm was dissolved except for a residual portion of 10 mm located in the area of insertion of the right renal artery. After dissolution of the thrombus it proved possible to restore the blood flow into the left kidney a and lower extremities, but not into the right kidney because of the residual thrombus. Seventy-two hours after terminated fibrinolysis - and after 31 days of anuria - the diuresis was restored and after a polyuric stage normalization of mineral, urea levels was restored and the creatinine value was slightly above the upper normal range. Concurrently with fibrinolytic therapy angioplasty of the aorta was carried out and a stent was placed on the left iliac artery. The clinical condition of the patient was improving, the patient started to mount stairs. Death occurred suddenly and the cause was cardiac failure due to very serious congenital heart disease.
authors.affiliation: Interní klinika FN, Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Bastecký
authors.forename: A
authors.initials: A
authors.lastname: Krajina
authors.forename: P
authors.initials: P
authors.lastname: Eliás
authors.forename: J
authors.initials: J
authors.lastname: Kvasnicka
authors.forename: A
authors.initials: A
authors.lastname: Michl
authors.forename: E
authors.initials: E
authors.lastname: Simáková
authors.forename: M
authors.initials: M
authors.lastname: Lojík
authors.forename: P
authors.initials: P
authors.lastname: Fixa
authors.forename: R
authors.initials: R
authors.lastname: Stilec
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal; D001018:Aortic Diseases / Q000150:complications / Q000188:drug therapy*; D004437:Ebstein Anomaly / Q000150:complications; D006801:Humans; D008297:Male; D012078:Renal Artery Obstruction / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Subakutní trombóza brisní aorty suprarenálnĕ zasahující, úspĕsnĕ lécená farmakomechanickou fibrinolýzou.