Toward salivary-urinary chronosensitivity testing: chronomes of OVX1, M-CSF and CA130.
Several rhythmic components were previously mapped for salivary and/or urinary CA125 and CA130. On the background of such reference standards, OVX1 and M-CSF were assayed on 242 urine samples and 160 saliva samples provided by a 71-year-old patient with a Müllerian/ovarian adenocarcinoma. Serum OVX1 correlates with serum CA125 (P = 0.002); when circulating CA125 concentrations decreased (from 122 to 14 U/ml), the urinary excretion rate of OVX1 decreased (P = 0.005), whereas the urinary excretion rate of CA125 increased (P < 0.001). Salivary OVX1 and urinary M-CSF show ultradian variations (with a frequency of one cycle in 14-17 hours), which could be utilized to guide treatment timing targeted first to optimize treatment efficacy and as a second consideration to minimize treatment toxicity.
Xu
F
F
Duke University Medical Center, Durham, North Carolina, USA.
Yu
Y
Y
Bast
R C
RC
Cornélissen
G
G
Fujii
S
S
Takagi
M
M
O'Brien
T
T
Halberg
F
F
D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000652:urine*; D014408:Biomarkers, Tumor / Q000652:urine*; D002909:Chronobiology Phenomena / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006023:Glycoproteins; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000652:urine*; D011506:Proteins; D012463:Saliva / Q000276:immunology* / Q000378:metabolism*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C083823:CA-130 antigen; D006023:Glycoproteins; C086414:OVX1 antigen; D011506:Proteins; D016173:Macrophage Colony-Stimulating Factor