title: Clinical assessment of adrenergic tone and responsiveness to beta-blocker therapy in patients with symptomatic ventricular tachycardia and no apparent structural heart disease.
abstract: To further define the relation between changing adrenergic tone, beta-blocker therapy, and clinical ventricular tachycardia (VT), we evaluated these factors in 35 patients with VT unrelated to coronary artery disease or ventricular dysfunction. Testing included Holter monitoring (91% had VT), exercise test (69% had VT), Adrenergic responsiveness of VT was graded according to diurnal variation, response to exercise, isoproterenol infusion, and response to beta-blockers. beta-Blockers were effective and well tolerated in this population. There was also a predictable relation between changing adrenergic tone and the arrhythmia response to beta-blocker therapy.
authors.affiliation: Department of Medicine, University of California Irvine Medical Center, Orange 92668-3298, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Brodsky
authors.forename: M V
authors.initials: MV
authors.lastname: Orlov
authors.forename: B J
authors.initials: BJ
authors.lastname: Allen
authors.forename: Y S
authors.initials: YS
authors.lastname: Orlov
authors.forename: L
authors.initials: L
authors.lastname: Wolff
authors.forename: R
authors.initials: R
authors.lastname: Winters
mesh_terms: D000293:Adolescent; D000320:Adrenergic Fibers / Q000187:drug effects* / Q000502:physiology; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D004558:Electric Stimulation; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology; D012890:Sleep / Q000502:physiology; D013566:Sympathomimetics / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000188:drug therapy* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D013566:Sympathomimetics; D007545:Isoproterenol