title: Changes in intraocular pressure during low dose intravenous sedation with propofol before cataract surgery.
abstract: OBJECTIVE
  This study examined the effects on intraocular pressure, pulse rate, and blood pressure of low dose intravenous sedation with propofol.
  
  
  METHODS
  Twenty adult patients who were scheduled to undergo cataract surgery were given a single intravenous bolus (0.98 (SEM 0.4) mg/kg) of propofol for sedation before administering the local anaesthetic for cataract surgery. A small intravenous dose of lignocaine was the only other anaesthetic or sedative agent given. The intraocular pressure in the non-surgery eye, the pulse rate, and the blood pressure were measured before and after propofol induction.
  
  
  RESULTS
  Compared with the preinduction baseline, there was a 17% to 27% (from 16.2 (0.7) mm Hg to 11.8 (0.7) mm Hg) decrease in intraocular pressure after propofol induction. A significant decrease in intraocular pressure occurred within the first minute and was still evident at 7 minutes when the measurements were stopped. There was also a 7%-12% increase in pulse rate during the first 4 minutes, a 12% decrease in mean systolic blood pressure, and a 7% decrease in mean diastolic blood pressure from baseline after propofol induction.
  
  
  CONCLUSIONS
  A single low dose bolus of propofol used for sedation before cataract surgery caused a moderate reduction in intraocular pressure with minimal, easily managed side effects.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: S
authors.initials: S
authors.lastname: Neel
authors.forename: R
authors.initials: R
authors.lastname: Deitch
authors.forename: S S
authors.initials: SS
authors.lastname: Moorthy
authors.forename: S
authors.initials: S
authors.lastname: Dierdorf
authors.forename: R
authors.initials: R
authors.lastname: Yee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol