title: Paradoxical puborectalis contraction is a feature of constipation in patients with multiple sclerosis.
abstract: OBJECTIVE
  To study the disturbed anorectal physiology associated with constipation in multiple sclerosis.
  
  
  METHODS
  Anorectal function in 10 patients with clinically definite multiple sclerosis and constipation has been compared with 10 normal persons and 11 patients with idiopathic constipation, without multiple sclerosis.
  
  
  RESULTS
  All 10 constipated patients with multiple sclerosis had difficulty evacuating barium paste during defaecography. In four of these there was complete failure of puborectalis relaxation when straining to defaecate, and in another four there was incomplete puborectalis relaxation. There was no evidence of lower motor neuron involvement of pelvic floor muscles in the multiple sclerosis group.
  
  
  CONCLUSIONS
  Paradoxical puborectalis contraction is common in patients with multiple sclerosis in whom constipation is a symptom. This may be a feature of the disturbed voluntary sphincter control mechanism, analogous to detrusor sphincter dyssnergia in the bladder.
authors.affiliation: Department of Surgery, Central Middlesex Hospital, London, UK.
authors.forename: Y W
authors.initials: YW
authors.lastname: Chia
authors.forename: K P
authors.initials: KP
authors.lastname: Gill
authors.forename: J S
authors.initials: JS
authors.lastname: Jameson
authors.forename: A D
authors.initials: AD
authors.lastname: Forti
authors.forename: M M
authors.initials: MM
authors.lastname: Henry
authors.forename: M
authors.initials: M
authors.lastname: Swash
authors.forename: P J
authors.initials: PJ
authors.lastname: Shorvon
mesh_terms: D000328:Adult; D001466:Barium Sulfate; D016022:Case-Control Studies; D003248:Constipation / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D003672:Defecation; D004576:Electromyography; D004733:Enema; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology; D009119:Muscle Contraction; D012007:Rectum / Q000503:physiopathology*
chemical_list: D001466:Barium Sulfate