Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to high-density 50-Hz magnetic fields.
Exposure to extremely low frequency magnetic field (ELFMF) of 50 Hz and 400 mT induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene of human melanoma MeWo cells. The mutant frequency was enhanced both by increasing the exposure period and the induced current intensity. Mutations induced by X-rays were enhanced by ELFMF exposure. No significant increase in mutant frequency occurred when DNA replication was inhibited during ELFMF exposure. DNA replication error is suspected of causing the mutations produced by ELFMF exposure.
Miyakoshi
J
J
Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Japan. miyakosh@minko.hyg.med.kyoto-u.ac.jp
Yamagishi
N
N
Ohtsu
S
S
Mohri
K
K
Takebe
H
H
D002455:Cell Division; D002470:Cell Survival; D004247:DNA / Q000528:radiation effects; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008280:Magnetics; D016296:Mutagenesis; D014407:Tumor Cells, Cultured
D004247:DNA; D007041:Hypoxanthine Phosphoribosyltransferase