title: Effects of Ganoderma lucidum and krestin on subset T-cell in spleen of gamma-irradiated mice.
abstract: Effects of Ganoderma lucidum (Gl) and Krestin (PSK) extracts on spleen, thymus and splenocytes in gamma-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A was the normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gy gamma-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in groups D and E were higher than group C on day 28 after gamma-irradiation. Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damage of subset T-cells in the spleen of gamma-irradiated mice.
authors.affiliation: Institute of Radiation Biology, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: W C
authors.initials: WC
authors.lastname: Chen
authors.forename: D M
authors.initials: DM
authors.lastname: Hau
authors.forename: C C
authors.initials: CC
authors.lastname: Wang
authors.forename: I H
authors.initials: IH
authors.lastname: Lin
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry; D005434:Flow Cytometry; D007369:Interferon Inducers / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D011509:Proteoglycans / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects*; D013997:Time Factors
chemical_list: D007369:Interferon Inducers; D011509:Proteoglycans; C010770:polysaccharide-K