Mazindol treatment for cocaine dependence.
This double-blind placebo-controlled treatment study tested the efficacy of mazindol in currently cocaine-dependent out-patients. Forty-three patients were randomized to mazindol (2 mg QD) vs. placebo treatment for 6 weeks. All patients received weekly group counseling. Patients improved with respect to objective (urine toxicology) and subjective (self-report of times used, dollars spent, craving, etc.) measures. There was no response difference between patients treated with mazindol and those who received placebo.
Stine
S M
SM
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.
Krystal
J H
JH
Kosten
T R
TR
Charney
D S
DS
D000328:Adult; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use*; D003042:Cocaine / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008454:Mazindol / Q000009:adverse effects / Q000627:therapeutic use*; D009460:Neurologic Examination / Q000187:drug effects; D015813:Substance Abuse Detection; D013375:Substance Withdrawal Syndrome / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000534:rehabilitation*
D000697:Central Nervous System Stimulants; D008454:Mazindol; D003042:Cocaine