title: [Platinum-based antineoplastic agents: biomedical applications and therapeutic aspects].
abstract: A survey of investigations performed over the last decade concerning analytical, clinical and pharmacological data on cancer chemotherapy with Pt-based drugs is reported. From this standpoint discussion focuses on clinical studies aimed at evaluating therapeutic response and toxicity during regional and systemic treatment of cisplatin against solid tumors in adults as well as in children. Concurrent treatments with locoregional hyperthermia in the case of limb tumors or with radiotherapy in the case of lung carcinoma are also dealt with.
authors.affiliation: Clinica Pediatrica, Universià degli Studi, La Sapienza, Roma.
authors.forename: C
authors.initials: C
authors.lastname: Dominici
authors.forename: F
authors.initials: F
authors.lastname: Petrucci
authors.forename: A
authors.initials: A
authors.lastname: Alimonti
authors.forename: F
authors.initials: F
authors.lastname: La Torre
authors.forename: A
authors.initials: A
authors.lastname: Cifani
authors.forename: S
authors.initials: S
authors.lastname: Caroli
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002945:Cisplatin / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D009944:Organoplatinum Compounds / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D002945:Cisplatin
vernacular_title: Composti antitumorali a base di platino: applicazioni biomediche e aspetti terapeutici.