title: Peroxidase activation of 4-hydroxytamoxifen to cause DNA damage in vitro.
authors.affiliation: MRC Toxicology Unit, University of Leicester, U.K.
authors.forename: A M
authors.initials: AM
authors.lastname: Davies
authors.forename: M E
authors.initials: ME
authors.lastname: Malone
authors.forename: I N
authors.initials: IN
authors.lastname: White
mesh_terms: D001711:Biotransformation; D004249:DNA Damage; D004578:Electron Spin Resonance Spectroscopy; D004965:Estrogen Antagonists / Q000378:metabolism* / Q000493:pharmacokinetics / Q000633:toxicity*; D005609:Free Radicals / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000378:metabolism; D066298:In Vitro Techniques; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D004965:Estrogen Antagonists; D005609:Free Radicals; D013629:Tamoxifen; C016601:afimoxifene; D006735:Horseradish Peroxidase; C062262:4-hydroxytoremifene