title: Acute subjective responses to paroxetine in normal volunteers.
abstract: The purpose of this study was to compare the subjective effects of the selective serotonin reuptake inhibitor, paroxetine, to those of the prototypic stimulant, d-amphetamine. Ten healthy volunteers attended 5 sessions and received paroxetine (10, 20, 50 mg), d-amphetamine (20 mg), and placebo. Subjective effects were measured at regular intervals for 26-30 h. Paroxetine and d-amphetamine produced highly dissimilar effects on mood. For example, whereas d-amphetamine increased ratings of euphoria, drug high, and desire for drug, paroxetine produced no effects on these measures. Conversely, whereas paroxetine increased ratings of Confusion and Fatigue, d-amphetamine did not. These findings suggest that serotonin does not play a significant role in mediating the positive subjective effects of stimulant drugs.
authors.affiliation: Department of Psychiatry, University of Chicago, IL 60637, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Brauer
authors.forename: M R
authors.initials: MR
authors.lastname: Rukstalis
authors.forename: H
authors.initials: H
authors.lastname: de Wit
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005059:Euphoria / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009042:Motivation; D017374:Paroxetine / Q000494:pharmacology*; D010555:Personality Inventory; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
chemical_list: D003913:Dextroamphetamine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors