Correlation of bone mineral density and femoral neck hardness in bovine and human samples.
Bone mineral density (BMD) is a predictor of fracture risk. The purpose of this study was to determine whether a correlation exists between femoral neck BMD and an indicator of mechanical bone strength in human and bovine samples. Human proximal femurs were obtained from seven men and two women undergoing total hip arthroplasty (THA), mean age 60.3 years. Preoperative BMD measurements of the femoral neck were obtained (Lunar DPX). A 3 cm2 area of interest on each excised femoral neck corresponding to the preoperative BMD measurement site was carefully marked and BMD was remeasured postoperatively. Ten excised bovine femoral necks were also measured for BMD. A bicortical core, each cortex 2.8 cm2 in area, containing the center of the area of interest was removed from the human and bovine femoral necks, cut into multiple 7-mm thick, multiple cross-sectional discs, and measured for hardness by indent depth (Rockwell International Hardness Tester, Wilson Mechanical Instruments, New York, NY). In vivo human femoral neck BMD measurements correlated with in vitro BMD measurements (r = 0.99). BMD measurements of human femoral necks were significantly lower than BMD measurements of bovine femoral necks (P < 0.05). Inverse relationships were found between in vivo and in vitro human BMD measurements and indent depth (r = -0.58 and -0.59, respectively). Bovine BMD measurements and indent depth were also inversely related (r = -0.64).(ABSTRACT TRUNCATED AT 250 WORDS)
Houde
J
J
Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical Center, Worcester 01655, USA.
Marchetti
M
M
Duquette
J
J
Hoffman
A
A
Steinberg
G
G
Crane
G K
GK
Baran
D
D
D000328:Adult; D000368:Aged; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000502:physiology*; D002417:Cattle; D005260:Female; D005272:Femur Neck / Q000502:physiology*; D006244:Hardness; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged