[Protective effects of Angelica sinensis injection on myocardial ischemia/reperfusion injury in rabbits].
The injection of aqueous extract of Angelica sinensis (AS), 50 mg/kg, 30 ml, were administered intravenously at a rate of 0.4 ml/min by an infusion pump 10 min before the left anterior descending coronary artery of rabbit was ligated, the LVP and +/- dp/dtmax of the rabbit heart injured by ischemia/reperfusion in vivo, were significantly higher than those in the control group (N.S. group, P < 0.05-0.01), and the level of malon-dialdehyde (MDA) and the activity of creatine phosphokinase (CPK) in the blood plasma were lower than those in the control group remarkably (P < 0.05-0.01). These results showed that AS exerted obvious protective effects on myocardial dysfunction and myocardial injury induced by ischemia/reperfusion.
Chen
S G
SG
Dept. Pharmacology, Medical College of Shantou University, Guangdong.
Li
C C
CC
Zhuang
X X
XX
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D011817:Rabbits
D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D003402:Creatine Kinase