Aetiopathogenesis of Takayasu's arteritis and BCG vaccination: the missing link?
Takayasu's arteritis is an inflammatory disease of unknown aetiology involving the aorta, its major branches and pulmonary arteries. Historical, epidemiological and immunological data are presented which suggest that BCG vaccination in the susceptible host might be important in the pathogenesis of Takayasu's arteritis. This hypothesis best explains the various known facts about the disease.
Kothari
S S
SS
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
D000942:Antigens, Bacterial / Q000096:biosynthesis / Q000276:immunology*; D001011:Aorta / Q000276:immunology / Q000378:metabolism; D001324:Autoantigens / Q000096:biosynthesis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D001500:BCG Vaccine / Q000009:adverse effects*; D001426:Bacterial Proteins; D018834:Chaperonin 60; D018833:Chaperonins / Q000096:biosynthesis / Q000276:immunology*; D003429:Cross Reactions; D003906:Developing Countries; D004198:Disease Susceptibility / Q000208:ethnology / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D059950:HLA-B52 Antigen; D006801:Humans; D007111:Immunity, Cellular; D007564:Japan / Q000453:epidemiology; D008297:Male; D018448:Models, Immunological; D018716:Molecular Mimicry; D009163:Mycobacterium bovis / Q000145:classification / Q000276:immunology*; D013625:Takayasu Arteritis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D014376:Tuberculosis / Q000150:complications / Q000517:prevention & control; D014611:Vaccination / Q000009:adverse effects* / Q000706:statistics & numerical data; D014651:Vasa Vasorum / Q000276:immunology / Q000378:metabolism
D000942:Antigens, Bacterial; D001324:Autoantigens; D001500:BCG Vaccine; D001426:Bacterial Proteins; D018834:Chaperonin 60; D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins