Insulin and prostaglandins as signals between tumor and the host immune system.
The development of malignant tissue in vivo is partially favored by the immunosuppression that occurs in cancer patients. However, the signals between tumor and immune tissues remain to be identified. We present evidence that prostaglandins may act as one of these signals by a direct action on cells of the immune system, or by inhibition of insulin secretion which in turn suppresses immune function, or both.
Curi
R
R
Departamento de Fisiologia e Biofísica, Universidade de São Paulo, Brasil.
Homem-de-Bittencourt
P I
PI
Costa-Rosa
L F
LF
Fernandes
L C
LC
el-Razi
S
S
Seelaender
M C
MC
Carpinelli
A R
AR
D000818:Animals; D002279:Carcinoma 256, Walker / Q000473:pathology; D018267:Carcinoma, Acinar Cell / Q000473:pathology; D006801:Humans; D007165:Immunosuppression Therapy; D007328:Insulin / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D000078790:Insulin Secretion; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats
D007328:Insulin; D011453:Prostaglandins