title: The structural basis of nuclear function.
abstract: Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.
authors.affiliation: CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
authors.forename: D A
authors.initials: DA
authors.lastname: Jackson
authors.forename: P R
authors.initials: PR
authors.lastname: Cook
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry; D006801:Humans; D015530:Nuclear Matrix / Q000648:ultrastructure; D011487:Protein Conformation
chemical_list: D002843:Chromatin; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase