title: Absorption of a new oral formulation of cyclosporin A in a child on parenteral nutrition.
abstract: A 2-year-old child underwent renal transplantation in the presence of a post-viral enteropathy rendering him dependent on total parenteral nutrition. As part of his immunosuppression, he was given a new oral formulation of cyclosporin A (Neoral), which he was able to absorb satisfactorily, using conventional doses, during the 6 weeks he was dependent on intravenous nutrition and in the face of intermittent severe diarrhoea. An unusual pharmacokinetic profile was observed.
authors.affiliation: Department of Child Health, Cardiff Royal Infirmary, Wales, UK.
authors.forename: F E
authors.initials: FE
authors.lastname: Jewkes
authors.forename: H R
authors.initials: HR
authors.lastname: Jenkins
authors.forename: R
authors.initials: R
authors.lastname: Lord
authors.forename: K
authors.initials: K
authors.lastname: Verrier Jones
mesh_terms: D000284:Administration, Oral; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D010289:Parenteral Nutrition, Total; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000378:metabolism / Q000628:therapy*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine