title: YM-47141 and YM-47142, new elastase inhibitors produced by Flexibacter sp. Q17897. II. Structure elucidation.
abstract: YM-47141 and YM-47142 are new elastase inhibitor produced by Flexibacter sp. Q17897. These structures were elucidated by MS and NMR spectral analysis. YM-47141 and YM-47142 were the cyclic peptides containing tricarbonyl moiety hydrated on the center carbonyl carbon in DMSO-d6.
authors.affiliation: Molecular Chemistry Research Lab, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Orita
authors.forename: K
authors.initials: K
authors.lastname: Yasumuro
authors.forename: K
authors.initials: K
authors.lastname: Kokubo
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Tokunaga
authors.forename: H
authors.initials: H
authors.lastname: Kaniwa
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; D015842:Serine Proteinase Inhibitors; C097796:YM 47141; C097797:YM 47142; D010196:Pancreatic Elastase