[Toxic tricyclic drug plasma level caused by fluoxetine].
A case study illustrates that even after discontinuation fluoxetine still increases amtitriptyline plasma-levels. This is caused by an inhibition of the metabolism of tricyclics by fluoxetine which was still active due to the long elimination half-life of this substance and its metabolite.
Hambrecht
M
M
Psychiatrische Klinik Zentralinstitut für Seelische Gesundheit, Mannheim.
D000639:Amitriptyline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006327:Heart Block / Q000097:blood / Q000139:chemically induced; D006801:Humans; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D009661:Nortriptyline / Q000493:pharmacokinetics; D012008:Recurrence
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine; D000639:Amitriptyline; D009661:Nortriptyline
Toxische Trizyklika-Plasmaspiegel durch Fluoxetin.