Analysis of TCR usage in human tumors: a new tool for assessing tumor-specific immune responses.
Tumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences. Here, Marialuisa Sensi and Giorgio Parmiani analyze the available information on TCR usage by T cells present in the infiltrate of histologically different tumors and suggest that the analysis of TCR sequences represents a powerful new tool to assess the in vivo immune response to growing tumors. Ultimately, this strategy may lead to the identification and manipulation of T-cell populations endowed with antitumor reactivity.
Sensi
M
M
Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy.
Parmiani
G
G
D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D000951:Antigens, Neoplasm; D011948:Receptors, Antigen, T-Cell