[The effect of basic therapy on the morphological picture of the rectal mucosa in patients with rheumatoid arthritis].
140 rectal mucosa biopsies were obtained from 86 patients with rheumatoid arthritis (RA), from 54 RA patients prior to or after a year basic therapy with either methotrexate or sulfa drug (sulfasalazine or salazopyridazine). 80% of the examinees exhibited large macrophages, lymphoid follicules, IgM- and IgG-containing cells. The knowledge of the initial morphologic changes in the rectal mucosa from RA patients helps predict efficacy of methotrexate or sulfonic drug treatment. Rectoromanoscopy with biopsy proved important diagnostic tool in RA capable of differentiating the disease variants, prompting valid therapeutic approach with control of the treatment results.
Frizen
B N
BN
Panchenko
K I
KI
Vinogradov
Iu N
IuN
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology*; D001706:Biopsy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011351:Proctoscopy; D012007:Rectum / Q000187:drug effects* / Q000473:pathology*; D012460:Sulfasalazine / Q000031:analogs & derivatives / Q000627:therapeutic use
D018501:Antirheumatic Agents; C009943:salazodin; D012460:Sulfasalazine; D008727:Methotrexate
Vliianie bazisnoĭ terapii na morfologicheskuiu kartinu slizistoĭ obolochki priamoĭ kishki u bol'nykh revmatoidnym artritom.