title: Catatonic syndrome following recovery from neuroleptic malignant syndrome.
abstract: In June 1992, a 51-year-old Caucasian man with a mild learning disability was prescribed chlorpromazine and thioridazine for sleeplessness and agitation. He developed neuroleptic malignant syndrome (NMS) which was treated successfully with intravenous diazepam. Without further exposure to neuroleptics, the patient became acutely unwell with signs of catatonic syndrome in March 1993 and responded to oral diazepam. When the dose of diazepam was reduced in August 1993, the catatonic syndrome recurred and responded to an increase in his oral diazepam. In the past, the patient had been admitted to hospital in 1983 and 1986 with severe extrapyramidal symptoms and parkinsonism following prescription of neuroleptics for agitation. This case provides evidence that patients with a predisposition to catatonic syndrome may be at increased risk of developing NMS, and therefore, should not be treated with neuroleptics.
authors.affiliation: Department of Psychiatry, St Mary's Hospital, London, England.
authors.forename: J
authors.initials: J
authors.lastname: Dent
mesh_terms: D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002389:Catatonia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D002746:Chlorpromazine / Q000009:adverse effects* / Q000627:therapeutic use; D003975:Diazepam / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000523:psychology; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000523:psychology; D013577:Syndrome; D013881:Thioridazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D013881:Thioridazine; D003975:Diazepam; D002746:Chlorpromazine