Infantile osteopetrosis; bone marrow transplantation from a cousin donor.
The successful correction of infantile osteopetrosis in an Asian child by bone marrow transplantation (BMT) from an HLA-A,B matched cousin donor is reported. Retrospective HLA molecular analysis revealed that patient and donor were incompatible for HLA-DPB1. Donor type cells detected in the patient after transplantation indicate successful engraftment. The patient is currently alive and well.
Taylor
G M
GM
Immunogenetics Laboratory, St Marys Hospital, Manchester.
Dearden
S P
SP
Will
A M
AM
Evans
D I
DI
Stevens
R F
RF
Simon
S
S
Super
M
M
Morrell
G
G
Fergusson
W D
WD
Brown
I H
IH
D016026:Bone Marrow Transplantation; D005260:Female; D006680:HLA Antigens; D015235:HLA-B Antigens; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; D006648:Histocompatibility; D006801:Humans; D007223:Infant; D010022:Osteopetrosis / Q000235:genetics / Q000276:immunology / Q000601:surgery*; D010375:Pedigree
D006680:HLA Antigens; D015235:HLA-B Antigens; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen