title: Animal models of protective immunity in tuberculosis to evaluate candidate vaccines.
abstract: While the etiology of tuberculosis is well understood, the nature of the protective immune response to the causative mycobacteria has remained a mystery. There is an urgent need to define protective immunity critically, and to develop alternative animal models to evaluate the efficacy of new-generation vaccines against tuberculosis in a cost-effective way.
authors.affiliation: Dept of Microbiology, University of Otago, Dunedin, New Zealand. frank.griffin@stonebow.otago.ac.nz
authors.forename: J F
authors.initials: JF
authors.lastname: Griffin
authors.forename: C G
authors.initials: CG
authors.lastname: Mackintosh
authors.forename: G S
authors.initials: GS
authors.lastname: Buchan
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007109:Immunity; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine