title: Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents.
abstract: Two flavivirus-like viruses, GB virus-A (GBV-A) and GB virus-B (GBV-B), were recently identified in the GB hepatitis agent, and are distinct from the hepatitis A to E viruses. The putative helicase domain of GBV-A and GBV-B was found to have amino acid sequence homology with hepatitis C virus (HCV), and distantly, is also related to pestiviruses, flaviviruses, and plant viruses. A phylogenetic tree construction showed that GBVs and HCV are closely related, and they are clustered with pestiviruses, flaviviruses and plant viruses in that order.
authors.affiliation: Second Department of Medicine, Nagoya City University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohba
authors.forename: M
authors.initials: M
authors.lastname: Mizokami
authors.forename: J Y
authors.initials: JY
authors.lastname: Lau
authors.forename: E
authors.initials: E
authors.lastname: Orito
authors.forename: K
authors.initials: K
authors.lastname: Ikeo
authors.forename: T
authors.initials: T
authors.lastname: Gojobori
mesh_terms: D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D005416:Flavivirus / Q000502:physiology*; D016174:Hepacivirus / Q000502:physiology; D008969:Molecular Sequence Data; D009029:Mosaic Viruses / Q000502:physiology*; D010576:Pestivirus / Q000502:physiology*; D010802:Phylogeny; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases