title: Use of antimicrobial-impregnated polymethyl methacrylate beads for treatment of chronic, refractory septic arthritis and osteomyelitis of the digit in a bull.
abstract: A 6-year-old 895-kg Angus bull was evaluated for a 6-month history of left hind limb lameness that was refractory to antimicrobial treatment. On physical examination, there was soft-tissue swelling associated with the lateral digit. Radiography revealed septic arthritis of the distal interphalangeal joint and osteomyelitis of the distal and middle phalanges. Treatment included debridement and lavage. Bacteriologic culture of debrided tissues yielded aerobic and anaerobic organisms. Antimicrobials were administered parenterally and locally in the form of antimicrobial-impregnated polymethyl methacrylate beads. The limb also was placed in a cast to promote ankylosis. The bull recovered, and the digit was salvaged.
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Trostle
authors.forename: D A
authors.initials: DA
authors.lastname: Hendrickson
authors.forename: W C
authors.initials: WC
authors.lastname: Stone
authors.forename: A A
authors.initials: AA
authors.lastname: Klohnen
mesh_terms: D000190:Actinomyces / Q000302:isolation & purification; D000196:Actinomycosis / Q000188:drug therapy / Q000662:veterinary; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use; D002751:Chlortetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D003646:Debridement / Q000662:veterinary; D005534:Foot Diseases / Q000188:drug therapy / Q000662:veterinary; D006614:Hindlimb; D006724:Hoof and Claw; D008297:Male; D008768:Methylmethacrylates; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D008863:Microspheres; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D010653:Phenylbutazone / Q000008:administration & dosage / Q000627:therapeutic use; D007507:Therapeutic Irrigation / Q000662:veterinary
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002511:Cephalosporins; D008768:Methylmethacrylates; D008795:Metronidazole; D010653:Phenylbutazone; D002437:Cefazolin; D002751:Chlortetracycline