New tumor antigens recognized by T cells.
A series of tumor cell antigens that are recognized by cytolytic T lymphocytes has been characterized this year. Besides the antigens derived from proteins specifically expressed in tumors, many melanoma antigens derive from melanocytic differentiation proteins. In addition, antigens unique to individual tumors result from mutations in ubiquitously expressed genes.
Van den Eynde
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Ludwig Institute for Cancer Research, Brussels, Belgium.
Brichard
V G
VG
D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000302:isolation & purification; D014408:Biomarkers, Tumor / Q000276:immunology; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D008546:Melanoma, Experimental / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology*
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor