title: Mediastinal tuberculous lymphadenitis: MR imaging appearance with clinicopathologic correlation.
abstract: OBJECTIVE
  The purpose of our study was to determine the MR imaging appearance of mediastinal tuberculous lymphadenitis and to compare these findings with clinical and pathologic findings.
  
  
  METHODS
  MR images of 23 consecutive patients with mediastinal tuberculous lymphadenitis were retrospectively analyzed with regard to homogeneity, signal intensity, and enhancement of diseased nodes after injection of contrast material (n = 19), and the imaging findings were grouped by patterns and correlated with clinical signs or symptoms and with pathologic (n = 9) findings.
  
  
  RESULTS
  Three imaging patterns of mediastinal tuberculous lymphadenitis (113 nodes) were seen of MR images. In six patients, nodes (type 1, n = 25) were relatively homogeneous and hyperintense to muscle on both T1- and T2-weighted images and enhanced homogeneously after injection of contrast material. The patients had mild (n = 2) or no (n = 4) constitutional symptoms. The nodes corresponded pathologically to tuberculous granulomas without or with minimal necrosis. In 14 patients, nodes (type 2, n = 71) were inhomogeneous with a strong peripheral enhancement after injection of contrast material. Enhancing areas were of intermediate intensity on T1-weighted images and hypointense on T2-weighted images, and corresponded pathologically to peripheral granulation tissue within the nodes. Unenhanced areas were relatively hypointense on T1-weighted images and markedly hyperintense on T2-weighted images, and corresponded pathologically to central caseation or liquefaction necrosis within the nodes. All but one patient with type 2 nodes had moderate to severe clinical signs and symptoms. In the remaining three patients, nodes (type 3, n = 17) were homogeneously hypointense on both T1- and T2-weighted images and did not enhance after injection of contrast material. No patient with type 3 nodes had clinical signs or symptoms. The nodes corresponded pathologically to fibrocalcified nodes.
  
  
  CONCLUSIONS
  The most common MR imaging appearance of mediastinal tuberculous lymphadenitis was as inhomogeneous nodes with marked hyperintensity on T2-weighted images and peripheral enhancement after injection of contrast material. This typical MR imaging appearance was mostly seen in severely symptomatic patients and was due to caseation necrosis of the tuberculous nodes.
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Korea.
authors.forename: W K
authors.initials: WK
authors.lastname: Moon
authors.forename: J G
authors.initials: JG
authors.lastname: Im
authors.forename: I K
authors.initials: IK
authors.lastname: Yu
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: K M
authors.initials: KM
authors.lastname: Yeon
authors.forename: M C
authors.initials: MC
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology