[Imaging of infectious and inflammatory foci using 111In-DTPA-IgG].
We performed radionuclide scanning after intravenous administration of 80 MBq of 111In-labeled non-specific polyclonal human immunoglobulin G (111In-DTPA-IgG). Serial scintigrams were acquired at 6, 24, 48, and 72 hr after injection in 10 patients suspected of having inflammation and/or infection. In 5 patients, the results of scintigraphy were verified with intraoperative cultures or biopsy. The values were as follow: sensitivity: 100% (4/4); specificity 50% (3/6); accuracy: 70% (7/10); positive predictive value: 57.1% (4/7); and negative predictive value: 100% (3/3). The results indicate that 111In-DTPA-IgG scintigraphy is certainly a promising method for the detection of inflammation and/or infection.
Kanegae
K
K
Department of Nuclear Medicine, Hokkaido University, School of Medicine.
Itoh
K
K
Tsukamoto
E
E
Kato
C
C
Nakada
K
K
Mochizuki
T
T
Shiga
T
T
Furudate
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D007239:Infections / Q000000981:diagnostic imaging*; D007249:Inflammation / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D004369:Pentetic Acid