Computation of the initial distribution of a drug by repetitive convolution with a circulatory transport function.
Hereby we present a widely applicable computational method for the description of recirculation and distribution phenomena occurring immediately after intravenous injection of a substance. The intravascular concentration-time course, r, is described as r = c0 + g * r, where the asterisk denotes the convolution operation, c0 is the concentration-time course during the first passage of the substance at an arterial measuring site and g is the transport function of the body. If the body transport function is known, then the arterial concentration-time course of a substance can be predicted for different amounts, injection times and elimination rates. The site of interest can be chosen arbitrarily, i.e. the concentration-time course in the arterial circulation supplying any organ can be described. This might be of special interest for the optimal design of intravenous injections of contrast media, where initial concentrations at the region of interest determine the success of the diagnostic procedure.
Schröder
T
T
Department of Experimental Anesthesiology, University of Göttingen, Germany.
Bouillon
T
T
Rösler
U
U
Hellige
G
G
D000818:Animals; D004396:Coloring Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006325:Heart Atria / Q000378:metabolism; D007208:Indocyanine Green / Q000008:administration & dosage / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008962:Models, Theoretical; D010599:Pharmacokinetics; D012756:Sheep; D014018:Tissue Distribution
D004396:Coloring Agents; D007208:Indocyanine Green