Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy.
Comparison of mid- and near-infrared spectra of control and infarcted rat ventricular tissue reveals the presence of absorptions in infarcted tissue which are highly characteristics of collagen, indicating large scale deposition of type I collagen in the myocardium following infarction. These results demonstrate that IR spectroscopy may be used to rapidly monitor the modifications of the extracellular matrix associated with myocardial infarction.
Lui
K
K
Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Manitoba.
Jackson
M
M
Sowa
M G
MG
Ju
H
H
Dixon
I M
IM
Mantsch
H H
HH
D000818:Animals; D003094:Collagen / Q000032:analysis* / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D006352:Heart Ventricles; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
D003094:Collagen