title: Trisomy 21 in acute myeloid leukemia.
abstract: We report two cases of acute myeloid leukemia (AML), constitutionally normal, with trisomy 21. Trisomy 21 does not often occur as a sole numerical karyotypic abnormality in AML leukemia. The possible prognostic significance of the finding in acute leukemia is discussed.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: C H
authors.initials: CH
authors.lastname: Wei
authors.forename: I T
authors.initials: IT
authors.lastname: Yu
authors.forename: C H
authors.initials: CH
authors.lastname: Tzeng
authors.forename: F S
authors.initials: FS
authors.lastname: Fan
authors.forename: R K
authors.initials: RK
authors.lastname: Hsieh
authors.forename: T J
authors.initials: TJ
authors.lastname: Chiou
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
authors.forename: P M
authors.initials: PM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D004314:Down Syndrome; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D015255:Idarubicin / Q000008:administration & dosage; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D008942:Mitoxantrone; D006918:Hydroxyurea; D015255:Idarubicin