Tricycloillicinone, a novel prenylated c6-c3 compound increasing choline acetyltransferase (ChAT) activity, isolated from Illicium tashiroi.
Tricycloillicinone (1), a novel tricyclic prenylated C6-C3 compound, has been isolated as a neurotrophic substance from the woods of Illicium tashiroi and its structure has been elucidated by spectroscopic analyses. Compound 1 could increase ChAT activity in culture of P10 rat septal neurons.
Fukuyama
Y
Y
Faculty of Pharmaceutical Sciences, Tokushima, Yokohama, Japan.
Shida
N
N
Kodama
M
M
Chaki
H
H
Yugami
T
T
D000818:Animals; D001921:Brain / Q000166:cytology / Q000201:enzymology; D002478:Cells, Cultured; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004149:Dioxoles / Q000302:isolation & purification* / Q000494:pharmacology; D008958:Models, Molecular; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013268:Stimulation, Chemical
D004149:Dioxoles; D010936:Plant Extracts; C098157:tricycloillicinone; D002795:Choline O-Acetyltransferase