title: [Spectroscopic imaging of the brain. Examination technique and clinical applications].
abstract: OBJECTIVE
  MR spectroscopy allows the acquisition of a two-dimensional array of spatially resolved proton spectra of the human brain, known as MR spectroscopic imaging. Here the examination protocol and clinical applications in focal brain lesions are presented.
  
  
  METHODS
  An array of data is acquired from a tissue slice positioned in the brain. These data can be presented as a set of spectra, in which each spectrum is allocated to a specific position in the sample, or as a set of images or "metabolite maps".
  
  
  RESULTS
  The NAA signal typical for neuronal tissue is decreased in the centre of brain tumours as well as in brain infarcts. The intensity of the choline signal is increased in solid tumour tissue, whereas it is reduced in infarcts.
  
  
  CONCLUSIONS
  Spectroscopic imaging reveals metabolite alterations in and around focal lesions. The spatial resolution of spectroscopic imaging enables matching with other macro-morphological or functional imaging methods like positron emission tomography.
authors.affiliation: Institut und Poliklinik für Radiologische Diagnostik, Universität zu Köln.
authors.forename: W
authors.initials: W
authors.lastname: Heindel
authors.forename: H
authors.initials: H
authors.lastname: Kugel
authors.forename: H
authors.initials: H
authors.lastname: Lanfermann
authors.forename: P
authors.initials: P
authors.lastname: Landwehr
authors.forename: T
authors.initials: T
authors.lastname: Krahe
authors.forename: K
authors.initials: K
authors.lastname: Lackner
mesh_terms: D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000473:pathology; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D007773:Lactates; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline