Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome.
Plasma interleukin-1 (IL-1) activity is modulated in part through the simultaneous appearance of several inhibitors of IL-1 action, including interleukin-1 receptor antagonist (IL-1ra) and the soluble IL-1 type II receptor (IL-1RII). However, little is known concerning the plasma appearance of these inhibitors in patients following operative trauma or those with sepsis syndrome. In the present report, plasma IL-1beta, IL-1ra, and soluble IL-1RI and IL-1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma. Plasma concentrations of IL-1ra increased significantly following elective operative repair of thoraco-abdominal and abdominal aortic aneurysms, and after bowel resection for inflammatory bowel disease, but did not increase after laparoscopic cholecystectomy. Plasma IL-1ra levels were also elevated in patients with sepsis syndrome. In contrast, soluble IL-1RII levels were only increased in patients after operative repair of thoraco-abdominal aortic aneurysms and in sepsis syndrome, whereas concentrations were unaffected by the other more modest surgical procedures. Plasma IL-1RI concentrations decreased in all postoperative patients in the first 24 hours after surgery. We conclude that both plasma IL-1ra and soluble IL-1RII concentrations often increase in sepsis and following some operative trauma. Less severe operative trauma increases the plasma concentration of only IL-1ra, whereas both IL-1ra and soluble IL-1RII are increased in patients with sepsis syndrome or following thoraco-abdominal aneurysm repair.
Pruitt
J H
JH
Department Surgery, University of Florida College of Medicine, Gainesville; USA.
Welborn
M B
MB
Edwards
P D
PD
Harward
T R
TR
Seeger
J W
JW
Martin
T D
TD
Smith
C
C
Kenney
J A
JA
Wesdorp
R I
RI
Meijer
S
S
Cuesta
M A
MA
Abouhanze
A
A
Copeland
E M
EM
Giri
J
J
Sims
J E
JE
Moldawer
L L
LL
Oldenburg
H S
HS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000097:blood / Q000601:surgery; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000097:blood / Q000601:surgery; D003082:Colectomy; D016638:Critical Illness; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000601:surgery; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D011184:Postoperative Period; D017472:Receptors, Interleukin-1 / Q000032:analysis* / Q000145:classification; D018805:Sepsis / Q000097:blood*; D012795:Sialoglycoproteins / Q000097:blood; D012995:Solubility; D013577:Syndrome; D014656:Vascular Surgical Procedures
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins