title: Increased activation of coagulation and formation of late deep venous thrombosis following discontinuation of thromboprophylaxis after hip replacement surgery.
abstract: Hip replacement surgery (HRS) is associated with a high frequency of deep vein thrombosis (DVT). At the same time there is a substantial systemic and local activation of coagulation. This study indicates that discontinuation of thromboprophylaxis one week after surgery may allow a second wave of coagulation and fibrinolysis activation to occur. An almost parallel increase in plasma TAT and D-dimer levels between the 6th and the 35th postoperative day may indicate late DVT formation. Repeated bilateral ascending venography is though to be necessary to evaluate the suitability of using selected activation markers of the coagulation and fibrinolytic systems as indices of DVT formation.
authors.affiliation: Dept. of Medicine, Ullevaal University Hospital, Oslo, Norway.
authors.forename: O E
authors.initials: OE
authors.lastname: Dahl
authors.forename: T
authors.initials: T
authors.lastname: Aspelin
authors.forename: H
authors.initials: H
authors.lastname: Arnesen
authors.forename: I
authors.initials: I
authors.lastname: Seljeflot
authors.forename: P
authors.initials: P
authors.lastname: Kierulf
authors.forename: R
authors.initials: R
authors.lastname: Ruyter
authors.forename: T
authors.initials: T
authors.lastname: Lyberg
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology; D000990:Antithrombin III / Q000378:metabolism*; D017985:Dalteparin / Q000494:pharmacology; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism*; D010690:Phlebography; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood* / Q000000981:diagnostic imaging / Q000517:prevention & control; D013924:Thrombophlebitis / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D000925:Anticoagulants; D017395:Plasminogen Activator Inhibitor 1; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator; D017985:Dalteparin