[Treatment of heart failure in dogs with ACe inhibitors: comparison of quinapril and captopril].
In this study 72 dogs the efficacy and safety of quinapril and captopril in the treatment of canine heart failure were found to be comparable. Differences exist between the dosage schedules of both ACE inhibitors. The recommended dosage schedule for the short acting captopril is three times daily 0.5 mg/kg bodyweight. Quinapril belongs to a newer generation of ACE inhibitors with a longer half life. Therefore a dosage of 0.5 mg/kg KGW once daily was in most cases sufficient for a successful therapy. This means that quinapril can ease the management of canine heart failure, because at least in dogs with mild to moderate heart failure the dosing interval is longer compared to captopril. Moreover, the treatment of small dogs is easier, because quinapril is available as 5 mg tablets whereas the smallest captopril tablets contain 12.5 mg agent.
Morisse
B
B
Klinik für kleine Haustiere, Tierärztlichen Hochschule Hannover.
Kersten
U
U
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D002216:Captopril / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary; D004283:Dog Diseases; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D000077583:Quinapril; D044005:Tetrahydroisoquinolines
D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D002216:Captopril; D000077583:Quinapril