title: Aspergillosis of the sphenoid sinus: presentation as a pituitary mass and postoperative gallium-67 imaging.
abstract: Invasive aspergillosis of the paranasal sinuses is an uncommon, but well-recognized, form of fungal infection. We describe an elderly female patient with invasive aspergillosis of the sphenoid sinus and associated osteomyelitis of the skull base, with clinical presentation as a pituitary mass. Postoperative gallium scan showed intense uptake in the sphenoid sinus, which resolved after treatment with amphotericin-B. This case demonstrates some of the pathologic and clinical features of invasive aspergillosis and suggests a potential role for gallium-67 imagining in monitoring clinical response to therapy.
authors.affiliation: Department of Pathology, Princeton Baptist Medical Center, Birmingham, Alabama, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Parker
authors.forename: J K
authors.initials: JK
authors.lastname: Nicholson
authors.forename: R C
authors.initials: RC
authors.lastname: Cezayirli
authors.forename: P J
authors.initials: PJ
authors.lastname: Biggs
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D001230:Aspergillus / Q000302:isolation & purification; D003937:Diagnosis, Differential; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000175:diagnosis*; D015524:Sphenoid Sinusitis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery
chemical_list: D005710:Gallium Radioisotopes; D000666:Amphotericin B