title: Origin of circulating group II phospholipase A2 in hepatocytes in a patient with epitheloid hemangioendothelioma of the liver.
abstract: The concentration of group II phospholipase A2 was measured in blood plasma samples before and after liver transplantation in a 27-year-old woman who suffered from a massive epitheloid hemangioendothelioma of the liver. The pretransplantation concentration of group II phospholipase A2 was 830 microg/L, which is markedly above the upper limit of the reference interval (10.8 microg/L). After the transplantation, there was a dramatic decrease in the group II phospholipase A2 level (33 microg/L on the first posttransplantation day). In situ hybridization of mRNA and immunohistochemistry revealed synthesis of group II phospholipase A2 in hepatocytes in non-neoplastic areas of the liver. Tumor cells did not contain group II phospholipase A2. The results indicate that group II phospholipase A2 circulating in blood plasma originates in hepatocytes.
authors.affiliation: Department of Pathology, University of Turku, Finland.
authors.forename: T J
authors.initials: TJ
authors.lastname: Nevalainen
authors.forename: M
authors.initials: M
authors.lastname: Kallajoki
authors.forename: E
authors.initials: E
authors.lastname: Pesonen
authors.forename: S
authors.initials: S
authors.lastname: Andersson
authors.forename: P
authors.initials: P
authors.lastname: Kärkkäinen
authors.forename: K
authors.initials: K
authors.lastname: Höckerstedt
mesh_terms: D000328:Adult; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000201:enzymology* / Q000235:genetics / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000601:surgery; D016031:Liver Transplantation / Q000502:physiology; D010741:Phospholipases A / Q000097:blood* / Q000145:classification / Q000235:genetics; D054467:Phospholipases A2; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012334:RNA, Neoplasm; D010741:Phospholipases A; D054467:Phospholipases A2