Toxicity evaluation of two treatment regimens for cyanide poisoning.
Toxicological evaluation of two recently reported treatment protocols for cyanide--SN (sodium nitrite) + DMAP (4-dimethylaminophenol) and SN + HA (hydroxylamine)--was carried out in male rats. Both treatments produced transient hyperammonaemia and decreased mean arterial pressure. Heart rate decreased and respiratory rate increased, but these changes reached the level of significance only after SN + HA. Histopathological lesions in lung, liver (SN+HA) and kidney (SN+DMAP) were predominantly in the vicinity of blood vessels. The results indicate toxic effects in both treatment groups at a dose known to induce methaemoglobin concentration to the level of antidotal efficiency in cyanide intoxication.
Bhattacharya
R
R
Division of Pharmacology and Toxicolgy, Defence Research and Development Establishment, Gwalior, India.
Pant
S C
SC
Kumar
D
D
Dube
S N
SN
D000627:Aminophenols / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use / Q000633:toxicity*; D003486:Cyanides / Q000037:antagonists & inhibitors / Q000627:therapeutic use / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000627:therapeutic use / Q000633:toxicity*; D007668:Kidney / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000627:therapeutic use / Q000633:toxicity*
D000627:Aminophenols; D000931:Antidotes; D003486:Cyanides; D006898:Hydroxylamines; D019811:Hydroxylamine; D012977:Sodium Nitrite; C020292:4-dimethylaminophenol