title: Effect of 6-OHDA lesions on striatal mRNA levels encoding for glutamate receptor subunits.
abstract: Levels of mRNAs encoding for subunits of glutamate receptors were measured by in situ hybridization in the rat striatum after unilateral injections of 6-hydroxydopamine in the substantia nigra. When compared with the contralateral striatum, levels of NMDAR1, GluR1 and GluR2 mRNAs were significantly higher in the dopamine-deafferented striatum. Comparison with saline-injected rats showed that the NMDAR1 and the GluR1 mRNA labelling was increased in the striatum ipsilateral to the lesion. In contrast, GluR2 mRNA labelling in 6-OHDA-injected rats was not different from that in saline-injected rats. These results support the hypothesis that experimental dopamine deafferentation induces functional changes at the level of glutamatergic synapses in the striatum.
authors.affiliation: Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Tremblay
authors.forename: P
authors.initials: P
authors.lastname: Salin
authors.forename: J J
authors.initials: JJ
authors.lastname: Soghomonian
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects*; D000818:Animals; D001483:Base Sequence; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003714:Denervation; D005815:Genetic Code; D008297:Male; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects; D016627:Oxidopamine; D012333:RNA, Messenger / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D017470:Receptors, Glutamate; D016627:Oxidopamine