Pulmonary myxoid leiomyosarcoma.
A primary myxoid leiomyosarcoma arising from the peripheral bronchus of the right middle lobe was removed from a 20 year old man and examined by immunohistochemistry and electron microscopy. The tumor was well circumscribed, yellow-whitish focal polypoid growth into the bronchial lumen and consisted of spindle cells with abundant myxoid substance in the stroma. Intrapulmonary metastasis, invasion to the bronchial wall and a few mitotic figures were found. Immunohistochemically, several, but not all, tumor cells were positive against anti-vimentin, anti-S-100 protein, anti-myosin and anti-muscle specific actin. Ultrastructurally, tumor cells had thin filaments with dense bodies, pinocytic vesicles and discontinuous basal lamina. These findings indicate a myoxoid variant of leiomyosarcoma arising from mesenchyme in the peribronchial area.
Koizumi
N
N
Second Department of Pathology, Niigata University School of Medicine, Japan.
Fukuda
T
T
Ohnishi
Y
Y
Naito
M
M
Emura
I
I
Sato
K
K
Hirono
T
T
Suzuki
E
E
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000473:pathology* / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008297:Male