title: Clinicopathologic correlation of submacular membranectomy with retention of good vision in a patient with age-related macular degeneration.
abstract: We present the clinicopathologic features of the eye of a patient with age-related macular degeneration who underwent submacular membranectomy and had retention of good visual acuity for almost 4 years despite recurrent choroidal neovascularization treated with krypton laser photocoagulation and mild expansion of the laser lesion with time. Histopathologic study of the surgically removed membrane from the right eye disclosed a thin fibrovascular membrane lined by retinal pigment epithelium on one surface. Microscopic examination of the right eye obtained post mortem disclosed a 2.75-mm (horizontal) x 2.1-mm (vertical) retinal pigment epithelium defect with overlying photoreceptor cell atrophy centered on the temporal parafoveal area, and a 0.6 x 0.1-mm subretinal pigment epithelium fibrovascular membrane with an area of retinal pigment epithelial hyperplasia and vascularization from the retina 0.4 mm temporal to the fovea. Basal laminar deposit was present in the region of the fovea and nasal parafoveal area.
authors.affiliation: Eye Pathology Laboratory, Wilmer Institute, The Johns Hopkins Medical Institutions, Baltimore, Md., USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Rosa
authors.forename: M A
authors.initials: MA
authors.lastname: Thomas
authors.forename: W R
authors.initials: WR
authors.lastname: Green
mesh_terms: D000368:Aged; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation; D008266:Macula Lutea / Q000473:pathology* / Q000601:surgery; D008268:Macular Degeneration / Q000150:complications*; D008566:Membranes / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D014785:Vision, Ocular; D014792:Visual Acuity; D014821:Vitrectomy