Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.
A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 microM, respectively.
Enomoto
Y
Y
Reseaarch Center for Biological Function, The Kitasato Institute, Tokyo 108, Japan.
Shiomi
K
K
Hayashi
M
M
Masuma
R
R
Kawakubo
T
T
Tomosawa
K
K
Iwai
Y
Y
Omura
S
S
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits
D000470:Alkaloids; D010975:Platelet Aggregation Inhibitors; C098363:herquline B