title: Electrophysiologic mechanisms of perpetuation of atrial fibrillation.
abstract: The presence of an excitable gap during atrial fibrillation (AF), although short and variable, may be of potential importance for the development of alternative techniques for termination of AF by rapid pacing. Also the notion that perpetuation of AF may be partly dependent on macroreentry around the natural atrial orifices, may provide a new therapeutic option for the permanent cure of AF by interrupting the anatomical circular pathways in the atria by radiofrequency ablation. In our opinion the rapidly growing understanding of the electrophysiologic mechanisms of AF certainly warrants some optimism about the possibility of cure of AF in the near future without causing too much discomfort and without carrying on unacceptable risk.
authors.affiliation: Department of Physiology, Maastricht University of Limburg, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Allessie
authors.forename: K
authors.initials: K
authors.lastname: Konings
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirchhof
authors.forename: M
authors.initials: M
authors.lastname: Wijffels
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000628:therapy; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D004594:Electrophysiology; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008297:Male; D013997:Time Factors