[Comparison of in vitro action of cetylpyridinium chloride containing preparations].
The fungicidal efficacy on Candida albicans of cetylpyridinium chloride (CAS 123-03-5) solution (CPC I solution, Dobendan) in various dilutions was tested with help of the quantitative suspension test and compared with CPC containing self-made preparations with or without addition of alcohol. The dilution of all test preparations caused an impairment of antimicrobial efficacy; the activity was reduced distinctly: due to a 50% dilution a decrease of 2-3 ten's powers was observed. The reduction of efficacy of the self-made preparation was less pronounced. The addition of 1% albumin as well impaired the fungicidal activity of all test preparations. CPC + alcohol revealed the most pronounced fungicidal efficacy; no differences were seen between CPC (without alcohol) and CPC I solution.
Deckers
C
C
Institut für Anästhesiologie, Medizinischen Universität zu Lübeck.
Ohgke
H
H
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002594:Cetylpyridinium / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D000431:Ethanol; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D000431:Ethanol; D002594:Cetylpyridinium