Inhaled nitric oxide in children with pulmonary hypertension and congenital mitral stenosis.
We demonstrated selective pulmonary vasodilation in patients with congenital mitral stenosis with inhaled NO, and used NO as prolonged therapy to stabilize the postintervention course of these children. The pulmonary vasoreactivity was greater than that previously reported in adults and may be due to particular sensitivity of pulmonary veins to inhaled NO when pulmonary venous hypertension has been present since birth.
Atz
A M
AM
Cardiac Intensive Care Unit, Children's Hospital, Boston, Massachusetts 02115, USA.
Adatia
I
I
Jonas
R A
RA
Wessel
D L
DL
D000280:Administration, Inhalation; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D008297:Male; D008946:Mitral Valve Stenosis / Q000150:complications* / Q000151:congenital; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000627:therapeutic use; D011652:Pulmonary Circulation / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
D014665:Vasodilator Agents; D009569:Nitric Oxide