title: Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment.
abstract: Reactivation of Chlamydia pneumoniae infection was studied by inducing immunosuppression by cortisone acetate treatment given every other day for 14 days in intranasally infected NIH/s mice. The treatment started 2 or 4 weeks after primary infection, when no C. pneumoniae was detected. C. pneumoniae could be recovered from the lung cultures on days 7 and 9 in 10 and 60% of the mice, respectively, when cortisone treatment was begun 30 days after infection. These results confirm the persistent nature of C. pneumoniae infection.
authors.affiliation: National Public Health Institute, Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Laitinen
authors.forename: A L
authors.initials: AL
authors.lastname: Laurila
authors.forename: M
authors.initials: M
authors.lastname: Leinonen
authors.forename: P
authors.initials: P
authors.lastname: Saikku
mesh_terms: D000818:Animals; D002690:Chlamydia Infections / Q000209:etiology* / Q000276:immunology; D016993:Chlamydophila pneumoniae; D003348:Cortisone / Q000494:pharmacology*; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice
chemical_list: D007166:Immunosuppressive Agents; D003348:Cortisone