title: Systemic mastocytosis in a goat.
abstract: Systemic mastocytosis was diagnosed in a 4-year-old, female Nubian goat. Clinically, the animal was depressed and had severe macrocytic hypochromic anemia and leukopenia. Postmortem examination revealed neoplastic mast cells invading the heart, lung, liver, spleen, lymph nodes, and bone marrow. Eosinophils were frequently admixed with infiltrating mast cells in all organs. Using routine light microscopy, histochemistry, and transmission electron microscopy, metachromatic and periodic acid-Schiff-positive granules were identified within the cytoplasm of neoplastic mast cells. Erythrophagocytosis was observed in some neoplastic cells, although its contribution to the anemia was not clear. This report represents the first description of mast cell neoplasia in the goat.
authors.affiliation: Department of Veterinary Pathobiology, Ohio State University, Columbus 43210, USA.
authors.forename: K N
authors.initials: KN
authors.lastname: Khan
authors.forename: J E
authors.initials: JE
authors.lastname: Sagartz
authors.forename: G
authors.initials: G
authors.lastname: Koenig
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000747:Anemia, Hypochromic / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D015511:Goat Diseases / Q000175:diagnosis / Q000473:pathology*; D006041:Goats; D006651:Histocytochemistry; D007970:Leukopenia / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008407:Mast Cells / Q000473:pathology / Q000648:ultrastructure; D012515:Mast-Cell Sarcoma / Q000473:pathology / Q000662:veterinary; D008415:Mastocytosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron / Q000662:veterinary; D009206:Myocardium / Q000473:pathology; D013154:Spleen / Q000473:pathology