title: Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1.
abstract: The process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1. In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.
authors.affiliation: Department of Neurology, National Institute for Medical Research, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Nosten-Bertrand
authors.forename: M L
authors.initials: ML
authors.lastname: Errington
authors.forename: K P
authors.initials: KP
authors.lastname: Murphy
authors.forename: Y
authors.initials: Y
authors.lastname: Tokugawa
authors.forename: E
authors.initials: E
authors.lastname: Barboni
authors.forename: E
authors.initials: E
authors.lastname: Kozlova
authors.forename: D
authors.initials: D
authors.lastname: Michalovich
authors.forename: R G
authors.initials: RG
authors.lastname: Morris
authors.forename: J
authors.initials: J
authors.lastname: Silver
authors.forename: C L
authors.initials: CL
authors.lastname: Stewart
authors.forename: T V
authors.initials: TV
authors.lastname: Bliss
authors.forename: R J
authors.initials: RJ
authors.lastname: Morris
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology; D005260:Female; D018390:Gene Targeting; D006624:Hippocampus / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018800:Thy-1 Antigens / Q000235:genetics / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018800:Thy-1 Antigens; D005680:gamma-Aminobutyric Acid