title: Synthesis, chemical and pharmacological properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides.
abstract: The synthesis and properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides (1-15) are reported. Imide 11, containing 2-hydroxy-3-(4-phenyl-l-piperazinyl) propyl substituent at the nitrogen atom, proved to have the lowest toxicity and, at very high dosages, to be the most pharmacologically active.
authors.affiliation: Department of Chemistry of Drugs, Wroclaw University of Medicine, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sĺadowska
authors.lastname: Potoczek
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: A
authors.initials: A
authors.lastname: Semczuk
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D005260:Female; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D000661:Amphetamine