Antimutagens reduce ofloxacin-induced bleaching in Euglena gracilis.
The genotoxic effect of ofloxacin was significantly decreased by standard antimutagens (sodium selenite, ascorbic acid, butylated hydroxyanisole and butylated hydroxytoluene) in the unicellular flagellate Euglena gracilis. The antiofloxacin activity of sodium selenite was also documented by a bacterial test in which the repair-proficient strain Salmonella typhimurium TA102 was used.
Ebringer
L
L
Institute of Molecular and Subcellular Biology, Faculty of Science, Comenius University, Odborárske nám. 5, 81107 Bratislava, Slovak Republic.
Dobias
J
J
Krajcvoic
J
J
Polónyi
J
J
Krizková
L
L
Lahitová
N
N
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005056:Euglena gracilis / Q000187:drug effects*; D015242:Ofloxacin / Q000633:toxicity*; D018038:Sodium Selenite / Q000494:pharmacology
D000890:Anti-Infective Agents; D016587:Antimutagenic Agents; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; D015242:Ofloxacin; D018038:Sodium Selenite; D001205:Ascorbic Acid