Bone marrow transplantation from bench to bedside.
Marrow grafting, now more appropriately called hematopoietic stem cell grafting, has come a long way from early bench studies and desperate bedside therapeutic attempts in terminal patients. Grafting of hematopoietic stem cells is now standard therapy for selected diseases and stages of disease, and increasing application on an outpatient basis is rapidly lowering the cost of the procedure. The combined efforts of the now many clinical marrow transplant teams and the interested basic science laboratories will undoubtedly make the coming decade an exciting and productive time for science and for the well-being of patients with otherwise incurable diseases.
Thomas
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Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
D000818:Animals; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000628:therapy