[Treatment of acute poisoning caused by carbamazepine, digoxin, and acetylsalicylic acid, with repeated doses of activated charcoal].
Twelve pediatric patients with acute poisonings caused by carbamazepine, digoxin and acetylsalicylic acid were treated with multiple doses of activated charcoal combined with a saline cathartic (adsorption surface of activated charcoal nearly 950 m2/g). This procedure was effective to shorten the plasmatic levels of the drugs, besides the clinical improvement of the poisoned patients. The average initial and final levels of the drugs were: carbamazepine 21.64 and 0.9 micrograms/ml (lowering 95.81%, p < 0.05), digoxin 5.14 and 1.1 ng/ml (lowering 78.6%, P < 0.05) and acetylsalicylic acid 418.5 and 57.5 micrograms/ml, respectively, (lowering 86.3%, p < 0.05). These results suggest the usefulness of activated charcoal in the clearance of the four overdosed drugs.
Montoya-Cabrera
M A
MA
Departamento de Urgencias y Toxicología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (IMSS).
Escalante-Galindo
P
P
Sauceda-García
J M
JM
Márquez-Enríquez
L M
LM
González-Cabello
H
H
Flores-Alvarez
E
E
D000208:Acute Disease; D000293:Adolescent; D000931:Antidotes / Q000008:administration & dosage*; D001241:Aspirin / Q000506:poisoning*; D002220:Carbamazepine / Q000506:poisoning*; D002606:Charcoal / Q000008:administration & dosage*; D002648:Child; D004077:Digoxin / Q000506:poisoning*; D004334:Drug Administration Schedule; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
D000931:Antidotes; D002606:Charcoal; D002220:Carbamazepine; D004077:Digoxin; D001241:Aspirin