Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors.
The preparation of hydroxylamine analogs of 2,6-di-tert-butylphenols (DTBP) and the inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) by these compounds is discussed.
Kramer
J B
JB
Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Capiris
T
T
Sircar
J C
JC
Connor
D T
DT
Bornemeier
D A
DA
Dyer
R D
RD
Kuipers
P J
PJ
Kennedy
J A
JA
Wright
C D
CD
Okonkwo
G C
GC
D000478:Alkylation; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors; D010084:Oxidation-Reduction; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents
D001577:Benzophenones; D016861:Cyclooxygenase Inhibitors; D006898:Hydroxylamines; D016859:Lipoxygenase Inhibitors; D010091:Oximes; D010636:Phenols; C098202:TZI 41078; D014665:Vasodilator Agents; C035407:2,6-di-tert-butylphenol; D019811:Hydroxylamine