title: Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
abstract: Structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.
authors.affiliation: Department of Chemistry, Wichita State University, KS 67260, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Groutas
authors.forename: M J
authors.initials: MJ
authors.lastname: Brubaker
authors.forename: L S
authors.initials: LS
authors.lastname: Chong
authors.forename: R
authors.initials: R
authors.lastname: Venkataraman
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: J B
authors.initials: JB
authors.lastname: Epp
authors.forename: R
authors.initials: R
authors.lastname: Kuang
authors.forename: J R
authors.initials: JR
authors.lastname: Hoidal
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D019272:Leukocyte Elastase; D053146:Myeloblastin; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases / Q000187:drug effects*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000596:Amino Acids; D004791:Enzyme Inhibitors; D015842:Serine Proteinase Inhibitors; D013388:Succinimides; C032620:succinimide; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D053146:Myeloblastin