title: Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol.
abstract: Nipradilol, a beta-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilation and plasma nitrite (NO2-) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO2- concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.
authors.affiliation: Department of Internal Medicine, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: A
authors.initials: A
authors.lastname: Udagawa
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Aikawa
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D002395:Catecholamines / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D009573:Nitrites / Q000097:blood*; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D009573:Nitrites; D011412:Propanolamines; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor; C036089:nipradilol; D006152:Cyclic GMP