title: Inhibitory influence from the nucleus reticularis pontis oralis on the micturition reflex induced by electrical stimulation of the pontine micturition center in cats.
abstract: An inhibitory influence from the nucleus reticularis pontis oralis on the micturition induced by electrical stimulation of the pontine micturition center was investigated in decerebrate cats at the supracollicular level. Monopolar electrical stimulation (30-50 microA, 0.2 ms, 50 Hz, 3 s) of the nucleus locus coeruleus alpha (pontine micturition center) produced micturition similar to that induced by distending the bladder by saline infusion. The intravesical pressure increase and micturition induced by electrical stimulation of the nucleus locus coeruleus alpha were suppressed by electrical stimulation of the nucleus reticularis pontis oralis in the intensity range 20-100 microA in a stimulus-intensity-dependent manner. These findings indicate that the nucleus reticularis pontis oralis has an inhibitory influence on the functions of the micturition center.
authors.affiliation: Department of Pharmacology, Nippon Shinyaku Co. Ltd., Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Ukai
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Sugaya
authors.forename: O
authors.initials: O
authors.lastname: Nishizawa
mesh_terms: D000818:Animals; D002415:Cats / Q000502:physiology*; D003655:Decerebrate State / Q000503:physiopathology; D004558:Electric Stimulation; D008125:Locus Coeruleus / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D011149:Pons / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation; D014554:Urination / Q000502:physiology*