[Localization of insulin-like growth factor I in the upper end of human fetal femur].
The localization of insulin-like growth factor I in the upper end of the human fetal femur was studied by immunohistochemistry on the undecalcified bone sections. Certain numbers of chondrocytes in germinal, proliferating and hypertrophic zones of the epiphysial growth plates, some osteoblasts and a few osteoclasts were immunoreactive to the antibody to IGF-I. The end-product of the DAB reaction was deposited in the osteoid and bone matrix of metaphysis. Also presented is a discussion on the local effects of IGF-I on the chondrocytes, osteoblasts and osteoclasts.
Yang
H
H
Wang
F
F
Li
R
R
Zhu
Z
Z
Li
G
G
D005269:Femur / Q000737:chemistry*; D005333:Fetus; D006132:Growth Plate / Q000737:chemistry* / Q000166:cytology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D010006:Osteoblasts / Q000737:chemistry; D010010:Osteoclasts / Q000737:chemistry
D007334:Insulin-Like Growth Factor I