Effects of ketanserin on heart rate and blood pressure variability: implications for the effect on the baroreflex mechanisms.
Ketanserin is an antihypertensive drug with affinity to both serotonin S2- and alpha 1-adrenoceptors. The specific effects of ketanserin on the baroreflex are not fully understood. We, therefore, studied baroreflex regulation based on blood pressure (BP) and heart rate (HR) responses to several maneuvers before and after the administration of 2 x 5 mg of ketanserin i.v. both in supine and in standing posture. Seven young healthy volunteers were investigated. We measured spontaneous variability in HR and BP (Finapres), and performed deep inspiration, Valsalva, and lying-to-standing tests. We also used a modified Valsalva maneuver that consist of Deep Inspiration Breath-holding with closed glottis and EXpiration: DIBEX maneuver. From the BP recordings, peripheral resistance (TPR) and stroke volume (SV) were estimated by the Modelflow method. Thirty minutes after the administration of ketanserin, there was no significant change in mean HR, BP, spectral power of HR and BP variability, baroreflex sensitivity, or Valsalva ratio. Thus ketanserin did not affect the cardiac baroreflex mechanism. However, in standing position, SV increased and TPR decreased under the influence of ketanserin, and BP overshoot after the Valsalva and DIBEX maneuver was significantly decreased as well. There was also no reflex recovery of BP during the DIBEX maneuver in three volunteers, who felt faint. These observations indicate that there is a lack of vasoconstriction. We conclude that ketanserin is not a vasodilator but seems to inhibit vasoconstriction.
Kingma
R
R
Department of Anesthesiology, Vrije Universiteit Amsterdam, The Netherlands.
Scheffer
G J
GJ
TenVoorde
B J
BJ
Wesseling
K H
KH
de Lange
J J
JJ
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007320:Inspiratory Capacity / Q000187:drug effects; D007650:Ketanserin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011187:Posture; D013318:Stroke Volume / Q000187:drug effects; D014636:Valsalva Maneuver / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000959:Antihypertensive Agents; D007650:Ketanserin