title: Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.
abstract: Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV-1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV-1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.
authors.affiliation: University of Alabama at Birmingham, School of Public Health, Department of Epidemiology, Birmingham, Alabama 35294, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Kaslow
authors.forename: M
authors.initials: M
authors.lastname: Carrington
authors.forename: R
authors.initials: R
authors.lastname: Apple
authors.forename: L
authors.initials: L
authors.lastname: Park
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: A J
authors.initials: AJ
authors.lastname: Saah
authors.forename: J J
authors.initials: JJ
authors.lastname: Goedert
authors.forename: C
authors.initials: C
authors.lastname: Winkler
authors.forename: S J
authors.initials: SJ
authors.lastname: O'Brien
authors.forename: C
authors.initials: C
authors.lastname: Rinaldo
authors.forename: R
authors.initials: R
authors.lastname: Detels
authors.forename: W
authors.initials: W
authors.lastname: Blattner
authors.forename: J
authors.initials: J
authors.lastname: Phair
authors.forename: H
authors.initials: H
authors.lastname: Erlich
authors.forename: D L
authors.initials: DL
authors.lastname: Mann
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015331:Cohort Studies; D008040:Genetic Linkage; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D015497:HIV-1 / Q000302:isolation & purification*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D016019:Survival Analysis
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II