A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma.
Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein. Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET.
Urano
F
F
Department of Pathology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Umezawa
A
A
Hong
W
W
Kikuchi
H
H
Hata
J
J
D017500:Adenovirus E1A Proteins / Q000096:biosynthesis / Q000235:genetics*; D000293:Adolescent; D001483:Base Sequence; D003001:Cloning, Molecular; D017931:DNA Primers; D004273:DNA, Neoplasm; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D034802:RNA-Binding Protein EWS; D012261:Ribonucleoproteins / Q000096:biosynthesis / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D017500:Adenovirus E1A Proteins; D017931:DNA Primers; D004273:DNA, Neoplasm; C079853:ETV4 protein, human; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D034802:RNA-Binding Protein EWS; D012261:Ribonucleoproteins