Patterns of cell proliferation in actinic keratoacanthomas and squamous cell carcinomas of the skin. Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections.
We report the pattern of cell proliferation in 20 cases of actinic keratoacanthomas and 20 cases of squamous cell carcinomas of the skin as shown by a new monoclonal antibody, MIB 1, raised against the recombinant Ki-67 antigen. The substantial differences between proliferation patterns in these two entities emphasize the different nature of these two entities.
Skálová
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Soft Tissue and Skin Tumor Registry, Sikls Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic.
Michal
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D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D005404:Fixatives; D005557:Formaldehyde; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007636:Keratoacanthoma / Q000473:pathology*; D019394:Ki-67 Antigen; D008867:Microtomy; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D009687:Nuclear Proteins / Q000032:analysis* / Q000276:immunology; D016612:Paraffin Embedding; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D005404:Fixatives; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D005557:Formaldehyde