New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum.
Three new steroids, zhankuic acids A [1], B [2], and C [3], were isolated from the fruiting bodies of Antrodia cinnamomea by bioassay-guided fractionation. The structures of these compounds were elucidated by chemical reactions and detailed analysis of their 1H- and 13C-nmr spectra. Biological studies revealed that 1 exhibited cytotoxic activity against P-388 murine leukemia cells and 2 showed weak anticholinergic and antiserotonergic activities.
Chen
C H
CH
School of Pharmacy, National Taiwan University, Taipei, Republic of China.
Yang
S W
SW
Shen
Y C
YC
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003460:Crystallization; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008516:Medicine, Chinese Traditional; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011124:Polyporaceae / Q000737:chemistry*; D012702:Serotonin Antagonists / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018680:Cholinergic Antagonists; D012702:Serotonin Antagonists; C098367:zhankuic acid A; C098370:zhankuic acid B; C098428:zhankuic acid C; D004875:Ergosterol