title: Hereditary polymorphic light eruption of American Indians: occurrence in non-Indians with polymorphic light eruption.
abstract: BACKGROUND
  Hereditary polymorphic light eruption (HPLE) occurs unique ly in the American Indian and Inuit and exhibits autosomal dominant transmission. Because the cutaneous expression of HPLE resembles that of polymorphic light eruption (PLE) and because many non-Indians in the United States have American Indian heritage, some instances of PLE may actually be HPLE.
  
  
  OBJECTIVE
  Our purpose was to determine whether non-Indian patients with PLE have characteristics suggestive of HPLE.
  
  
  METHODS
  We surveyed in Nebraska 25 European-Caucasian and 36 African-American patients with PLE for American Indian heritage and photosensitive relatives. Nonphotosensitive subjects (52 Caucasians and 40 African Americans) were surveyed for American Indian heritage.
  
  
  RESULTS
  American Indian heritage occurred in 11 Caucasian patients (44%); of those, seven (64%) had photosensitive relatives. Likewise, 29 African Americans (81%) had American Indian heritage; 19 (66%) of those had photosensitive relatives. American Indian heritage occurred in 10 Caucasian control subjects (19%) and in 34 African-American control subjects (85%).
  
  
  CONCLUSIONS
  If American Indian heritage and a family history of photosensitivity are definitive for HPLE, seven (28%) of our Caucasian patients and 19 (53%) of our African-American patients have HPLE rather than PLE. We urge physicians who suspect PLE in non-Indians to ask about American Indian heritage and photosensitive relatives and to screen their present patients with PLE for such characteristics.
authors.affiliation: Department of Internal Medicine/Dermatology, University of Nebraska Medical Center, Omaha, 68198-4360, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Fusaro
authors.forename: J A
authors.initials: JA
authors.lastname: Johnson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005060:Europe; D005260:Female; D005799:Genes, Dominant; D006630:Hispanic or Latino; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D004930:Inuit / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009329:Nebraska; D010787:Photosensitivity Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011536:Prurigo / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American