The c Fos immunoreactivities in the developing and adult rat cerebella.
c Fos immunoreactivities were studied by immunohistochemistry in the developing and adult rat cerebella. c Fos immunoreactivities were observed in purkinje cells early in postnatal development (P26 d) and reached a peak by P40-P60 d, followed by a decline in the 3-month-old adult. The granule cells revealed c Fos immunoreactivities by P26 d but declined until P50 d. Then c Fos immunoreactivities increased in the granule layer by P50-P60 d and decreased again in the adult. The deep nuclei showed c Fos immunoreactivities by P40 d and persisted in the adult. In spite of the difference in the patterns of location in c Fos immunoreactivities from the early postnatal period to adulthood, no decrease in the amount of c Fos immunoreactivity was evident from immunoblotting studies. Thus, it is concluded that c Fos immunoreactivities change from development to adult, but this does not affect the total amount of c Fos protein expression in the cerebellum.
Ruan
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Y
Department of Anatomy, Sun Yat Sen Medical University, Guanzhou, China.
Li
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WW
Lam
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DW
Yew
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DT
D000367:Age Factors; D000818:Animals; D002525:Cerebellar Cortex / Q000737:chemistry / Q000254:growth & development / Q000648:ultrastructure; D002531:Cerebellum / Q000737:chemistry* / Q000196:embryology / Q000254:growth & development; D015151:Immunoblotting; D016760:Proto-Oncogene Proteins c-fos / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000737:chemistry
D016760:Proto-Oncogene Proteins c-fos