title: Serum insulin-like growth factor-I and serum testosterone status of elderly men in an inpatient rehabilitation unit.
abstract: This study was designed to estimate the prevalence of hyposomatomedinemia and hypogonadism in an inpatient rehabilitation unit. The authors studied healthy young men (HOM) ages 20-29 years (n=33); healthy old men (HOM) ages 59-98 years (n=27), and elderly men in an inpatient rehabilitation unit (ERM) ages 58-95 years (n=42). Serum concentrations of insulin-like growth factor (IGF-I), total testosterone (TT), and free testosterone (FT) were measured. A low IGF-I level (below the lower 2.5 percentile of HYM) occurred in 85% of the HOM and in 62.5% of the ERM. When a low IGF-I was defined as a value below the 2.5 percentile of the HOM, the prevalence in ERM was 6.2%. A low TT level (below the lower 2.5 percentile of the HOM) occurred in 78% of the HOM and in 90% of the ERM. Low TT, defined as a value below the lower 2.5 percentile of the HOM, occurred in 22% of the ERM. The results with FT were similar. In neither HOM nor ERM was IGF-I significantly correlated to TT and FT. A large percentage of HOM and ERM have severe hypogonadism (TT<193 ng/mL) as compared with HOM. The ERM had a higher prevalence of severe hypogonadism as compared with the HOM.
authors.affiliation: Department of Physical Medicine & Rehabilitation, Medical College of Wisconsin, Milwaukee, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Kosasih
authors.forename: A A
authors.initials: AA
authors.lastname: Abbasi
authors.forename: D
authors.initials: D
authors.lastname: Rudman
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D006760:Hospitalization; D006801:Humans; D007006:Hypogonadism / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012046:Rehabilitation; D012047:Rehabilitation Centers; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D007334:Insulin-Like Growth Factor I