title: Rapamycin (sirolimus, rapamune).
abstract: Rapamycin is a novel immunosuppressive agent that is undergoing clinical trials for use in allograft rejection therapy. This paper reviews its in-vitro biological properties, the current state of knowledge concerning its mechanism of action, and its therapeutic applications.
authors.affiliation: Division of Endothelial Cell and Cytokine Biology, Wyeth-Ayerst Research, Princeton, New Jersey, USA.
authors.forename: S N
authors.initials: SN
authors.lastname: Sehgal
authors.forename: J S
authors.initials: JS
authors.lastname: Camardo
authors.forename: J A
authors.initials: JA
authors.lastname: Scarola
authors.forename: B T
authors.initials: BT
authors.lastname: Maida
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects; D011090:Polyenes / Q000494:pharmacology* / Q000627:therapeutic use; D020123:Sirolimus
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents; D011090:Polyenes; D020123:Sirolimus