title: HLA-DPB1 polymorphism in patients with rheumatoid arthritis in Taiwan.
abstract: OBJECTIVE
  To investigate the role of HLA-DP alleles in the pathogenesis of rheumatoid arthritis (RA).
  
  
  METHODS
  HLA-DPB1 alleles were studied in 144 patients with RA and 144 healthy controls using the polymerase chain reaction/sequence specific oligonucleotide probe method.
  
  
  RESULTS
  HLA-DPB1*0510 was the the most common allele in patients with RA and healthy controls in Taiwan. There was no significant difference in frequencies of HLA-DPB1 alleles between patients and controls. The HLA-DPB1 alleles were not associated with seropositivity for rheumatoid factor, extraarticular involvement, or bone erosion in patients. There was also no significant difference in frequencies of HLA-DPB1 alleles among DR4-positive and DR4-negative patients and controls.
  
  
  CONCLUSIONS
  There was no significant difference in the prevalences of HLA-DPB1 alleles between Taiwanese patients with RA and healthy controls. HLA-DPB1 alleles were not related to the clinical manifestations of patients with RA in Taiwan.
authors.affiliation: Department of Internal Medicine, Kaohsiung Medical College, Kaohsiung City, Taiwan.
authors.forename: J H
authors.initials: JH
authors.lastname: Yen
authors.forename: J R
authors.initials: JR
authors.lastname: Chen
authors.forename: W J
authors.initials: WJ
authors.lastname: Tsai
authors.forename: J J
authors.initials: JJ
authors.lastname: Tsai
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013624:Taiwan
chemical_list: D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D015345:Oligonucleotide Probes