title: Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors.
abstract: The preparation of hydroxylamine analogs of 2,6-di-tert-butylphenols (DTBP) and the inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) by these compounds is discussed.
authors.affiliation: Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Kramer
authors.forename: T
authors.initials: T
authors.lastname: Capiris
authors.forename: J C
authors.initials: JC
authors.lastname: Sircar
authors.forename: D T
authors.initials: DT
authors.lastname: Connor
authors.forename: D A
authors.initials: DA
authors.lastname: Bornemeier
authors.forename: R D
authors.initials: RD
authors.lastname: Dyer
authors.forename: P J
authors.initials: PJ
authors.lastname: Kuipers
authors.forename: J A
authors.initials: JA
authors.lastname: Kennedy
authors.forename: C D
authors.initials: CD
authors.lastname: Wright
authors.forename: G C
authors.initials: GC
authors.lastname: Okonkwo
mesh_terms: D000478:Alkylation; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors; D010084:Oxidation-Reduction; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents
chemical_list: D001577:Benzophenones; D016861:Cyclooxygenase Inhibitors; D006898:Hydroxylamines; D016859:Lipoxygenase Inhibitors; D010091:Oximes; D010636:Phenols; C098202:TZI 41078; D014665:Vasodilator Agents; C035407:2,6-di-tert-butylphenol; D019811:Hydroxylamine