title: Vocal cord injection with autogenous fat: a long-term magnetic resonance imaging evaluation.
abstract: Since 1987, the senior author has injected autogenous fat into paralyzed or atrophic vocal cords as an alternative to alloplastic substances for vocal cord augmentation and medialization. To determine the fate of the injected autogenous fat, the injected vocal cords of 10 patients were evaluated by laryngeal magnetic resonance imaging (MRI) in the sagittal, coronal, and axial planes. Imaging studies were performed as early as 17 hours after surgery to as long as 31 months after fat injection. In 9 patients, identification of a fat signal within the previously injected vocal cords was observed (including the 31-month postoperative follow-up). In 1 patient, no fat signal was identified 13 months after surgery, but the vocal cord was noted to have a bulging, enlarged contour. The results of this imaging study provide further evidence that autogenous fat, which has not been damaged during harvesting or microinjection, can survive transplantation into the vocal cord. The bulk of the vocal cord is maintained by microlipocytes and fibrous connective tissue, both of which replace the damaged fat cells that are gradually being reabsorbed.
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Brandenburg
authors.forename: J M
authors.initials: JM
authors.lastname: Unger
authors.forename: D
authors.initials: D
authors.lastname: Koschkee
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014826:Vocal Cord Paralysis / Q000175:diagnosis / Q000601:surgery*