title: Non-invasive detection of ibuprofen in vivo 13C-NMR signals in rats.
abstract: A non-invasive in vivo 13C-NMR experiment is performed to follow the metabolic pathway of ibuprofen in rats. Detection of possible intermediates and the stereoselectivity of ibuprofen chiral inversion process are discussed.
authors.affiliation: Biomedical Engineering & Instrumentation Program, NCRR, NIH, Bethesda, MD, USA.
authors.forename: C N
authors.initials: CN
authors.lastname: Chen
authors.forename: P C
authors.initials: PC
authors.lastname: Wang
authors.forename: H F
authors.initials: HF
authors.lastname: Song
authors.forename: Y C
authors.initials: YC
authors.lastname: Liu
authors.forename: C S
authors.initials: CS
authors.lastname: Chen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D002247:Carbon Isotopes; D005240:Feasibility Studies; D007052:Ibuprofen / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002247:Carbon Isotopes; D007052:Ibuprofen