title: Accumulation of 123I-IMP in extrahepatic metastases of hepatocellular carcinoma.
abstract: Twenty patients with 58 extrahepatic metastases of hepatocellular carcinoma (HCC) (41 bone, 5 lung, 6 peritoneum, 4 adrenal glands, 1 brain, 1 lymph node) underwent 123I-iodoamphetamine (123I-IMP) and gallium-67 (67Ga) scintigraphy. The rate of positivity with 123I-IMP planar imaging was 44% above the level of the diaphragm and 76% below the diaphragm, with an overall sensitivity of 62%. The combination of 123I-IMP scintigraphy and single photon emission tomography enabled positive visualization of an additional six metastatic foci: three in the adrenal glands, one in the peritoneum, one in the cranium and one in a rib. The rate of positivity with 67Ga planar imaging was 75% above the level of the diaphragm and 45% below the diaphragm, with an overall sensitivity of 58%. Our findings suggest that 123I-IMP is effective for detecting extrahepatic metastases of HCC, particularly those below the diaphragm.
authors.affiliation: Department of Radiology, Tottori University School of Medicine, Yonago, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suto
authors.forename: F
authors.initials: F
authors.lastname: Kodama
authors.forename: Y
authors.initials: Y
authors.lastname: Tanabe
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D000662:Amphetamines; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000556:secondary*; D016022:Case-Control Studies; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D002951:Citrates; D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D019343:Citric Acid; D020367:Iofetamine