title: Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond.
authors.affiliation: Department of Medicine, UCLA School of Medicine 90024, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Boado
authors.forename: Y S
authors.initials: YS
authors.lastname: Kang
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: W M
authors.initials: WM
authors.lastname: Pardridge
mesh_terms: D000818:Animals; D001483:Base Sequence; D015756:Genes, tat; D015497:HIV-1 / Q000201:enzymology; D066298:In Vitro Techniques; D008297:Male; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013462:Sulfur Radioisotopes; D013873:Thionucleotides / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; D013873:Thionucleotides