title: A simple quality control protocol for haemoximetry using standard p50.
abstract: We have designed a quality control tool for haemoximetry using the principle that standard p50, calculated from blood gas and haemoximetry measurements using the Siggaard-Andersen algorithm, remains unchanged when a specimen of venous blood is oxygenated progressively to 97% saturation of haemoglobin. If the haemoximeter is inaccurate, progressively larger deviations of standard p50 from the constant value occur above 80% saturation. Deviations too small to be detected by analysis of quality control materials comprised of non-haemoglobin dyes and yet sufficient to cause significant errors in derived extractivity parameters can be detected by this method. The suggested protocol is easy to perform, and is recommended as a quality control tool for blood gas analyser/haemoximeters used to determine arterial extractivity parameters.
authors.affiliation: Royal Brisbane Hospital, Queensland, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Morgan
authors.forename: A
authors.initials: A
authors.lastname: Clague
authors.forename: J
authors.initials: J
authors.lastname: Rayfield
authors.forename: Z
authors.initials: Z
authors.lastname: Endre
mesh_terms: D000465:Algorithms; D015982:Bias; D001784:Blood Gas Analysis / Q000295:instrumentation / Q000592:standards; D002138:Calibration; D004396:Coloring Agents / Q000737:chemistry; D006452:Hemoglobinometry / Q000295:instrumentation / Q000592:standards*; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D011786:Quality Control; D013053:Spectrophotometry
chemical_list: D004396:Coloring Agents; D006454:Hemoglobins; D010100:Oxygen