title: Optimising the removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water.
abstract: 1. The efficacy of ZnDTPA administered in drinking water has been investigated for removing 238Pu and 241Am from the rat after their simultaneous inhalation as nitrates. 2. The continual administration of ZnDTPA 95 mumol kg-1 d-1 over a 21 d interval commencing 1 h after exposure reduced the 238Pu content of the lungs and total body to 2% and 8% of those in untreated animals; the corresponding values for 241Am were 3% and 5%. 3. The continual intakes of 950 mumol kg-1 d-1, intermittent intakes of 3600 mumol kg-1 d-1 and the repeated injection of 30 mumol kg-1 body weight were considered no more effective. 4. All orally administered concentrations of ZnDTPA, commencing 7 d after exposure, reduced the total body contents of 238Pu and 241Am to 17% and 20% of controls by 28 d. 5. Histopathological examination of the kidneys, liver and gastrointestinal tract showed no apparent effects of these treatment protocols. 6. It is concluded that the oral administration of ZnDTPA could be an effective treatment for the removal of inhaled transportable forms of Pu and Am after human exposure.
authors.affiliation: National Radiological Protection Board, Didcot, Oxon, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Gray
authors.forename: M J
authors.initials: MJ
authors.lastname: Pearce
authors.forename: G N
authors.initials: GN
authors.lastname: Stradling
authors.forename: I
authors.initials: I
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Hodgson
authors.forename: K R
authors.initials: KR
authors.lastname: Isaacs
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000576:Americium / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D004326:Drinking; D004386:Duodenum / Q000187:drug effects / Q000473:pathology; D005260:Female; D007082:Ileum / Q000187:drug effects / Q000473:pathology; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000378:metabolism; D004369:Pentetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D011005:Plutonium / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D015032:Zinc / Q000494:pharmacology
chemical_list: D002614:Chelating Agents; D011005:Plutonium; D004369:Pentetic Acid; D015032:Zinc; D000576:Americium