title: Repair of coarctation of the aorta in adults: the fate of systolic hypertension.
abstract: BACKGROUND
  The benefit of coarctation repair in adults has been questioned by suggesting that hypertension may not be relieved by the operation and that surgical intervention may have no impact on the natural history of the disease.
  
  
  METHODS
  To delineate the impact of surgical intervention on systolic hypertension, we conducted a retrospective review of 26 adults with a mean age of 32 +/- 10 years who underwent coarctation repair between 1987 and 1993. All patients were hypertensive (mean systolic blood pressure, 174 +/- 21 mm Hg; range, 140 to 220 mm Hg), and 18 patients (69%) were on a regimen of at least one hypertensive medication at the time of surgical admission. All patients underwent catheterization, and the mean peak systolic gradient across the coarctation was 61 +/- 25 mm Hg (range, 25 to 120 mm Hg). Operation included resection and end-to-end anastomosis (3 patients), resection with an interposition tube graft (6 patients), a bypass graft (11 patients), and patch angioplasty (6 patients). There was no hospital mortality or late morbidity.
  
  
  RESULTS
  Intermediate follow-up was available at a mean of 2.3 +/- 2 years (range, 1 to 7 years). At last follow-up, the peak systolic gradient between the upper and lower body was trivial (< or = 10 mm Hg) in 23 patients (88%) and mild (11 to 20 mm Hg) in 3 (12%). All patients had significant improvement in systolic blood pressure (p < 0.001) compared to preoperative values, and the majority (23, 88%) were normotensive. More than half of the patients (14, 54%) were still on a regimen of antihypertensive medication at last follow-up, with a trend (p = 0.06) toward older patients requiring medication.
  
  
  CONCLUSIONS
  Surgical repair of coarctation in adults is an effective, low-risk procedure, which results in a significant improvement in systolic hypertension and a decreased requirement of antihypertensive medications.
authors.affiliation: German Heart Institute, Berlin, Germany.
authors.forename: W J
authors.initials: WJ
authors.lastname: Wells
authors.forename: T W
authors.initials: TW
authors.lastname: Prendergast
authors.forename: F
authors.initials: F
authors.lastname: Berdjis
authors.forename: D
authors.initials: D
authors.lastname: Brandl
authors.forename: P E
authors.initials: PE
authors.lastname: Lange
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
authors.forename: V A
authors.initials: VA
authors.lastname: Starnes
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001017:Aortic Coarctation / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D001794:Blood Pressure; D006328:Cardiac Catheterization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013599:Systole
chemical_list: D000959:Antihypertensive Agents