title: Cluster of five children with acute encephalopathy associated with cat-scratch disease in south Florida.
abstract: Between August 12 and September 27, 1994, five children in South Florida were hospitalized at a single hospital because of encephalopathy, presenting as status epilepticus, associated with cat-scratch disease (CSD). Diagnoses were confirmed by using an indirect fluorescent antibody test to detect antibody to Bartonella henselae, the causative agent of CSD. These cases represent the first cluster of CSD encephalopathy cases to be recognized in the United States. The patients lived within 7 miles of each other and all reported contact with pet or stray cats before developing regional lymphadenopathy and encephalopathy. All recovered fully. A high proportion of 124 cats from the local area were seropositive (62%) or bacteremic (22%). This study suggests that B. henselae can be associated with geographically focal clusters of CSD encephalitis and should be considered in the evaluation of children with acute encephalopathy.
authors.affiliation: Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Noah
authors.forename: J S
authors.initials: JS
authors.lastname: Bresee
authors.forename: M J
authors.initials: MJ
authors.lastname: Gorensek
authors.forename: J A
authors.initials: JA
authors.lastname: Rooney
authors.forename: J L
authors.initials: JL
authors.lastname: Cresanta
authors.forename: R L
authors.initials: RL
authors.lastname: Regnery
authors.forename: J
authors.initials: J
authors.lastname: Wong
authors.forename: J
authors.initials: J
authors.lastname: del Toro
authors.forename: J G
authors.initials: JG
authors.lastname: Olson
authors.forename: J E
authors.initials: JE
authors.lastname: Childs
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D000907:Antibodies, Bacterial / Q000032:analysis*; D018416:Bartonella henselae / Q000276:immunology* / Q000302:isolation & purification; D002372:Cat-Scratch Disease / Q000150:complications* / Q000453:epidemiology; D002415:Cats; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004285:Dogs; D004660:Encephalitis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male
chemical_list: D000907:Antibodies, Bacterial