Ocular involvement in Epstein-Barr virus-associated T-cell lymphoma.
OBJECTIVE
To determine if serous retinal detachment may occur in a case of Epstein-Barr virus-associated T-cell lymphoma.


METHODS
We examined a 51-year-old man who had recent loss of vision and poor general health.


RESULTS
Ocular involvement consisted of bilateral serous retinal detachment and choroidal infiltrates. The diagnosis of lymphoma was made by liver biopsy. The course of the disease was fulminant. Postmortem histologic examination disclosed a massive infiltration of the choroid and hematopoietic organs by pleomorphic large T cells. Epstein-Barr virus was detected by in situ hybridization.


CONCLUSIONS
Ocular involvement, including choroidal infiltrates and serous retinal detachment, may occur in Epstein-Barr virus-associated T-cell lymphoma.
Cochereau
I
I
Department of Ophthalmology, Bichat-Claude Bernard Hospital, Paris, France.
Hannouche
D
D
Geoffray
C
C
Toublanc
M
M
Hoang-Xuan
T
T
D002830:Choroid Neoplasms / Q000473:pathology / Q000821:virology*; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D015347:RNA Probes; D012163:Retinal Detachment / Q000209:etiology* / Q000473:pathology; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology
D015347:RNA Probes