title: Severe Burkholderia (Pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases.
abstract: Chronic granulomatous disease (CGD) is characterized by a defect in phagocytic cells that leads to recurrent superficial and deep pyogenic infections. Burkholderia (Pseudomonas) gladioli is a gram-negative bacillus in the pseudomallei group of pseudomonads that is known primarily as a plant pathogen. We report two cases of pneumonia, one accompanied by septicemia, caused by B. gladioli in patients with CGD and their successful treatment with antibiotics. We believe these represent the first reports of human disease caused by this organism. We conclude that B. gladioli should be considered a potential pathogen in patients with CGD.
authors.affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Ross
authors.forename: S M
authors.initials: SM
authors.lastname: Holland
authors.forename: V J
authors.initials: VJ
authors.lastname: Gill
authors.forename: E S
authors.initials: ES
authors.lastname: DeCarlo
authors.forename: J I
authors.initials: JI
authors.lastname: Gallin
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology; D019117:Burkholderia / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity; D019121:Burkholderia Infections / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents