title: Characterization of extrathymic T cells induced by recombinant murine interferon-beta in the peritoneal cavity of nude mice.
abstract: The effects of recombinant murine interferon-beta (rMuIFN-beta) on extrathymic lymphocyte formation in the peritoneal cavity of BALB/c athymic nude mice and tumor-bearing nude mice were examined for comparison with BALB/c normal euthymic mice. The 7 days of administration of 1 x 10(5) IU rMuIFN-beta caused the number of these cells to increase remarkably in the peritoneal cavity as a unique subset of asialoGM1+CD4+CD8-TcR alpha beta+ T cells. The asialoGM1+CD4+ T cells produced IL-2 and IFN-gamma in primary culture without stimulant but did not proliferate. Thus, extrathymic T cells can be induced easily in the peritoneal cavity in addition to the thymus for host defense systems.
authors.affiliation: Department of Allergology, Institute of Medical Science, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Moriyama
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: S T
authors.initials: ST
authors.lastname: Yee
authors.forename: H
authors.initials: H
authors.lastname: Nariuchi
authors.forename: M
authors.initials: M
authors.lastname: Iigo
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D000818:Animals; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D016130:Immunophenotyping; D007274:Injections, Intraperitoneal; D016899:Interferon-beta / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000166:cytology*; D011994:Recombinant Proteins / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins; D016899:Interferon-beta