Changes of carbohydrate-deficient transferrin in chronic alcoholism.
Compared with other well established liver enzyme parameters, carbohydrate-deficient transferrin (CDT) offers a new method for the identification of chronic alcoholism. The dependence of CDT and alcoholism/abstinence was studied in 29 controls and 64 alcoholics (both groups comprising men and women). In contrast to the currently used parameters GOT, GPT, gammaGT, LDH and MCV, CDT measures chronic alcoholism exclusively. CDT is dependent on sex but not age. In chronic alcoholism its rate increases significantly, but drops quickly after a short time of abstinence. CDT variations may be a specific and sensitive indicator of alcoholism or abstinence and possibly the duration.
König
P
P
Landeskrankenhaus Rankweil, Department of Psychiatry I, Austria.
Niederhofer
H
H
Steurer
H
H
Haller
R
R
Wölfle
R
R
Fritzsche
H
H
Weiss
P
P
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000201:enzymology; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D013695:Temperance; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism
D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin