[Immunohistochemical studies of the occurrence of "calcitonin gene-related peptide" (CGRP) in nasal mucosa of the human].
In addition to classic neurotransmitters, neuropeptides are believed to regulate functions of the nasal mucosa in man. The aim of this study was to localize the vasoactive neurotransmitter calcitonin gene-related peptide (CGRP) in different mucosal structures by immunocytochemical methods. Frozen sections of the inferior turbinates from 12 patients were incubated with antibodies to CGRP and immunocomplexes were visualized by the ABC (Avidin-Biotin-Complex) method. CGRP-positive nerve fibers were demonstrated in the adventitia of arteries and arterioles. Immunoreactions were also found in interstitial spaces and around ducts of seromucous glands. Additional immunoreactions were detectable in subepithelial nerves and mast cells. These morphologic findings indicate that CGRP may participate in the transmission of sensory stimuli, in vasoregulation and in allergic reactions. The occurrence of CGRP in the different anatomic structures suggests multiple roles of this neuropeptide in the nasal mucosa of man.
Riederer
A
A
Klinik und Poliklinik für HNO-Kranke, Ludwig-Maximilians-Universität München.
Knipping
S
S
Fischer
A
A
Unger
J
J
D000328:Adult; D001160:Arterioles / Q000473:pathology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008407:Mast Cells / Q000473:pathology; D009297:Nasal Mucosa / Q000098:blood supply / Q000294:innervation / Q000473:pathology* / Q000601:surgery; D015508:Nasal Obstruction / Q000473:pathology / Q000601:surgery; D009412:Nerve Fibers / Q000473:pathology; D014420:Turbinates / Q000473:pathology / Q000601:surgery
D015740:Calcitonin Gene-Related Peptide