title: Synthesis and characterization of iodixanol.
abstract: Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.
authors.affiliation: Research and Development, Nycomed Imaging AS, Oslo, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Priebe
authors.forename: H
authors.initials: H
authors.lastname: Dugstad
authors.forename: M
authors.initials: M
authors.lastname: Gacek
authors.forename: E
authors.initials: E
authors.lastname: Hagen
authors.forename: O M
authors.initials: OM
authors.lastname: Homestad
authors.forename: A
authors.initials: A
authors.lastname: Larsen
authors.forename: C E
authors.initials: CE
authors.lastname: Sjogren
authors.forename: T
authors.initials: T
authors.lastname: Thomassen
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D014283:Triiodobenzoic Acids / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol