The role of neovascularization in the survival of an arterialized venous flap.
This study compares survival of arterialized venous flaps placed on normal and impaired recipient beds in New Zealand White rabbit ear. Fasciocutanous flaps (4 x 5 cm) were perfused by an arteriovenous anastomosis; outflow was provided by one vein. In group 1, the arterialized venous flap was sutured into its bed on the ear; in group 2, a sheet of silicone was placed between the flap and the ear, providing an experimentally impaired recipient bed. Flap survival was expressed as a percentage of the total flap surface by means of a computerized image analysis system. Excellent survival (> or =95 percent) was noted in 16 of 21 arterialized venous flaps in group 1 versus 2 of 21 in group 2 (p < 0.01). Partial survival (50 to 94 percent) was observed in 2 of 21 arterialized venous flaps in group 1 and 15 of 21 in group 2. Poor survival (<50 percent) was noted in 3 of 21 in group 1 and in 4 of 21 in group 2. Microangiography was used to illustrate arteriovenous fistulas, the vascular network within the flaps, and neovessels in the periphery of the flaps. These data indicate that neovascularization is necessary for optimal survival of arterialized venous flaps in this experimental rabbit ear model.
Pittet
B
B
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, USA.
Chang
P
P
Cederna
P
P
Cohen
M B
MB
Blair
W F
WF
Cram
A E
AE
D000818:Animals; D001158:Arteries / Q000502:physiology; D004431:Ear, External / Q000098:blood supply* / Q000000981:diagnostic imaging; D005205:Fascia / Q000098:blood supply; D008852:Microradiography; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011817:Rabbits; D012867:Skin / Q000098:blood supply; D013524:Surgical Flaps / Q000379:methods*; D013536:Suture Techniques; D013997:Time Factors; D014022:Tissue Survival / Q000502:physiology*; D014680:Veins / Q000502:physiology