title: [Synthesis and positive inotropic activity of 3,4-dimethoxybenzoyl-piperazine derivatives].
abstract: We designed and synthesized twelve new 3,4-dimethoxybenzoyl-piperazine derivatives. These chemical structures (TM-1-TM-12) were confirmed by means of IR, MS, H-NMR and elemental analysis. Compounds (OPC-8212 TM-1, TM-2, VPA) were tested for positive inotropic activity. The results showed that compounds OPC-8212 and VPA possessed positive inotropic activity (P < 0.05). Further pharmacological studies will be made.
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.forename: D
authors.initials: D
authors.lastname: Deng
authors.forename: Y
authors.initials: Y
authors.lastname: Qin
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D002316:Cardiotonic Agents; D010879:Piperazines; C098227:TM 1