title: Laparoscopic surgery during pregnancy.
abstract: BACKGROUND
  Animal studies have demonstrated fetal acidosis during carbon dioxide pneumoperitoneum. This finding suggests a potential adverse effect of CO2 pneumoperitoneum on fetal outcome in humans.
  
  
  METHODS
  We reviewed our recent experience with laparoscopic surgery performed under general anesthesia and with the use of CO2 pneumoperitoneum, in pregnant women with appendicitis or cholecystitis. We compared these women's charts and pregnancy outcomes with those of pregnant women who underwent formal laparotomy during the same period of time.
  
  
  RESULTS
  Seven pregnant patients underwent laparoscopic surgery, and there were 4 fetal deaths among them (3 during the first postoperative week, and another 4 weeks postoperatively). Five pregnant patients underwent formal laparotomy, of whom 4 subsequently progressed to term and 1 was lost to follow-up.
  
  
  CONCLUSIONS
  Our recent experiences together with the available animal data suggest that caution should be used when considering nonobstetrical laparoscopic surgery in pregnant women. This experience suggests that additional clinical and laboratory investigations may be indicated to evaluate fetal risk associated with such surgery.
authors.affiliation: Department of Surgery, University of Mississippi School of Medicine, Jackson, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Amos
authors.forename: S J
authors.initials: SJ
authors.lastname: Schorr
authors.forename: P F
authors.initials: PF
authors.lastname: Norman
authors.forename: G V
authors.initials: GV
authors.lastname: Poole
authors.forename: K R
authors.initials: KR
authors.lastname: Thomae
authors.forename: A T
authors.initials: AT
authors.lastname: Mancino
authors.forename: T J
authors.initials: TJ
authors.lastname: Hall
authors.forename: C E
authors.initials: CE
authors.lastname: Scott-Conner
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000208:Acute Disease; D000768:Anesthesia, General; D001062:Appendectomy / Q000379:methods; D001064:Appendicitis / Q000601:surgery; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects; D002764:Cholecystitis / Q000601:surgery; D002769:Cholelithiasis / Q000150:complications / Q000601:surgery; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D010535:Laparoscopy / Q000009:adverse effects; D007813:Laparotomy; D010195:Pancreatitis / Q000209:etiology / Q000601:surgery; D011028:Pneumoperitoneum, Artificial; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery*; D011256:Pregnancy Outcome; D012307:Risk Factors