title: Effect of piribedil, a D-2 dopaminergic agonist, on dopamine, amino acids, and free radicals in gerbil brain after cerebral ischemia.
abstract: The excitatory amino acids (EAA) are involved in the pathogenesis of the cerebral ischemia. Moreover, several investigators have demonstrated that a considerable amount of dopamine (DA) is released in the striatum after ischemia reperfusion/insult (IRI). Recently, studies have demonstrated in vitro, that D-2 agonist, at the level of striatum and retina, may represent a powerful signal to inhibit release of excitatory amino acids implicated in cerebral ischemia. Therefore we have been incited to test, in vivo, the action of a D-2 agonist, piribedil, on gerbil brain after IRI. We have used the Stroke Index (SI); then to precise the mechanism of action, we have determined the levels of dopamine, EAA, and hydroxyl-free radicals (OH), in striatum, hippocampus, and hemisphere. Piribedil, administered at dose of 10 mg/kg, per os, 60 min before induction of transient cerebral ischemia in gerbils, presents a neuroprotective effect, as measured by SI and significantly reverses the increase of DA, EAA, and OH induced by IRI. The mechanism of action of piribedil could be related to its D-2 agonist property.
authors.affiliation: Faculté de Médecine, Tours, France.
authors.forename: B
authors.initials: B
authors.lastname: Delbarre
authors.forename: G
authors.initials: G
authors.lastname: Delbarre
authors.forename: C
authors.initials: C
authors.lastname: Rochat
authors.forename: F
authors.initials: F
authors.lastname: Calinon
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D018846:Excitatory Amino Acids / Q000378:metabolism; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D018846:Excitatory Amino Acids; D018696:Neuroprotective Agents; D017448:Receptors, Dopamine D2; D010891:Piribedil; D004298:Dopamine