Listeria rhombencephalitis: report of two cases with early diagnosis and favourable outcome.
We present 2 cases of Listeria monocytogenes rhombencephalitis (L-RE), both affecting previously healthy adult men. Each of them developed a diphasic syndrome first characterized by fever, nausea and headache, followed, in a second phase, by severe brain stem dysfunction at the level of the pons, with meningism, multiple cranial nerve palsies, ataxia, and, in one case, seizures. The early examination of the cerebrospinal fluid (CSF) demonstrated the presence of Gram-positive bacilli whose typical characteristics were compatible with those of Listeria, allowing for immediate administration of a specific therapy. Neuroimaging techniques (either CT or MRI) did not provide any evidence of brain stem involvement, and they did not positively contribute to the diagnostic process. The immediate use of a specific antibiotic therapy led to a favourable clinical outcome for both patients.
Bianchi
G
G
Department of Neurology V. University of Milan, San Gerardo Hospital, Monza (Mi), Italy.
Appollonio
I
I
Piolti
R
R
Pozzi
C
C
Frattola
L
L
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002556:Cerebrospinal Fluid Proteins; D003391:Cranial Nerves / Q000503:physiopathology; D004569:Electroencephalography; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D008089:Listeria monocytogenes / Q000302:isolation & purification*; D008088:Listeriosis / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000503:physiopathology; D012249:Rhombencephalon / Q000503:physiopathology*
D000900:Anti-Bacterial Agents; D002556:Cerebrospinal Fluid Proteins; D005947:Glucose