Innervation of the rabbit lumbar intervertebral disc and posterior longitudinal ligament.
METHODS
The present study sought to determine to what extent the lumbar intervertebral disc and posterior longitudinal ligament are innervated in the New Zealand white rabbit. The intent is to use this disc model in future neurophysiology studies.


OBJECTIVE
To characterize the distribution of nerve fibers and endings in the lumbar intervertebral disc and posterior longitudinal ligament in an animal model.


BACKGROUND
The results of previous disc innervation reports are somewhat conflicting regarding the density and depth of innervation into the anulus.


METHODS
A silver impregnation technique was used to analyze sections from lumbar intervertebral disc and posterior longitudinal ligament of the New Zealand white rabbit.


RESULTS
Numerous fine profiles of nerve fibers were demonstrated in the lumbar disc anulus and posterior longitudinal ligament. In the disc, the nerves were limited to the superficial anulus and anular surface. The nerve axons typically were 1 to 3 microns in diameter and were found around the entire periphery of the disc. No encapsulated endings were seen within the anulus, while occasional encapsulated endings were seen on the anular surface and posterior longitudinal ligament.


CONCLUSIONS
This study demonstrates an extensive distribution of small nerve fibers in the size range of C and A-delta fibers throughout the peripheral anulus and provides an illustration of this distribution. These findings support a role for the disc as a source of low back pain.
Cavanaugh
J M
JM
Bioengineering Center, Wayne State University, Detroit, Michigan, USA.
Kallakuri
S
S
Ozaktay
A C
AC
D000818:Animals; D007403:Intervertebral Disc / Q000294:innervation*; D017846:Longitudinal Ligaments / Q000294:innervation*; D008159:Lumbar Vertebrae / Q000294:innervation*; D008297:Male; D009411:Nerve Endings / Q000648:ultrastructure; D009412:Nerve Fibers / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D011817:Rabbits / Q000033:anatomy & histology*