Liver transplantation and its long-term management in children.
Liver transplantation is an effective treatment for end-stage liver disease in the pediatric population. The 1-year survival rate in the United States is now approximately 80%, with some series showing a 90% 1-year survival rate. Most children who receive liver transplantation attain normal growth and development. Many pitfalls remain, however, in the treatment for pediatric liver disease with transplantation, including donor-organ scarcity and immunosuppression-related side effects. This article reviews indications for liver transplantation and clinical management of patients who receive liver transplantation.
Lee
H
H
Department of Surgery, Children's Hospital, Boston, Massachusetts 02115, USA.
Vacanti
J P
JP
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007165:Immunosuppression Therapy; D007223:Infant; D007231:Infant, Newborn; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D008134:Long-Term Care / Q000379:methods*; D018579:Patient Selection; D015996:Survival Rate; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome