Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze.
The effects of ginsenosides Rg1, Rd and Rb1 on impaired performance induced in the rat by scopolamine were examined in a radial-arm maze. Scopolamine caused a reduction in the number of initial correct responses in the maze. A single IP injection of Rg1, but not Rd or Rb1, prevented the reduction. The inhibition of the reduction in initial correct responses was associated with a bell-shaped dose-response curve for Rg1. A lesion in the medial septum caused spatial learning deficits. Rg1 did not overcome these deficits. It is suggested that cholinergic neurons in the medial septum are involved in the ameliorative effect of Rg1 on impaired performance induced by scopolamine.
Yamaguchi
Y
Y
Research Laboratory, Zenyaku Kogyo Co. Ltd., Tokyo, Japan.
Haruta
K
K
Kobayashi
H
H
D000818:Animals; D001931:Brain Mapping; D002491:Central Nervous System Agents / Q000494:pharmacology*; D002799:Cholinergic Fibers / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D036145:Ginsenosides; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D009949:Orientation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology*; D012688:Septum Pellucidum / Q000187:drug effects
D002491:Central Nervous System Agents; D036145:Ginsenosides; D012503:Saponins; D012601:Scopolamine