title: High-grade astrocytomas.
abstract: Despite intense research, progress in the treatment of patients with HGA has remained slow. New therapeutic strategies are emerging, however, based on technologic advances in surgery and radiotherapy, improved understanding of the molecular, cellular, and immunobiology of astrocytomas, and advances in gene therapy, It is likely that these new strategies will result in significant progress in the treatment of HGA in the next decade.
authors.affiliation: Brain Tumor Center of Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: P Y
authors.initials: PY
authors.lastname: Wen
authors.forename: H A
authors.initials: HA
authors.lastname: Fine
authors.forename: P M
authors.initials: PM
authors.lastname: Black
authors.forename: D C
authors.initials: DC
authors.lastname: Shrieve
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: J S
authors.initials: JS
authors.lastname: Loeffler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D015996:Survival Rate