Behavioral changes with alterations of choline acetyltransferase immunoreactivities induced by N-butyl benzenesulfonamide.
N-butyl benzenesulfonamide (NBBS), one of the sulfonamide plasticizers, induced characteristic effects to Wistar rats after acute repeated exposures (300 mg/kg body weight, ip every 6 h). The signs were pica, staggering gait with hindlimb-paresis and splaying, teeth-grinding, self paw-biting and coma. The motor activity parameters showed generalized decreased mobility. The gait and hindlimb abnormalities coexisted with changes of lower motoneuron activity, ie decreased immunoreactivity of choline acetyltransferase in the lumbar spinal cord. The effects became more overt with repeated exposure to NBBS and the severity was increased. These effects were short-lived and the animals soon recovered.
Lee
W Y
WY
Department of Toxicology, National Institute of Safety Research, Seoul, Korea.
Hwang
S J
SJ
Cho
D H
DH
Kim
J S
JS
D000704:Analysis of Variance; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003128:Coma / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010968:Plasticizers / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000633:toxicity*; D000096926:Benzenesulfonamides
D002795:Choline O-Acetyltransferase; D010968:Plasticizers; D013449:Sulfonamides; C065565:N-butylbenzenesulfonamide; D000096926:Benzenesulfonamides