title: Intrathecal granuloma complicating chronic spinal infusion of morphine. Report of three cases.
abstract: Intrathecal morphine delivered by implanted pumps has been used in the treatment of pain caused by terminal cancer. Some authors supports its use in benign pain as well. The authors present three cases in which chronic infiltration of intraspinal narcotic medication was complicated by the formation of a granulomatous mass that became large enough to exert mass effect and induce neurological dysfunction.
authors.affiliation: Department of Neurosurgery and Radiology, University of Minnesota School of Medicine, St. Paul, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Blount
authors.forename: K B
authors.initials: KB
authors.lastname: Remley
authors.forename: S K
authors.initials: SK
authors.lastname: Yue
authors.forename: D L
authors.initials: DL
authors.lastname: Erickson
mesh_terms: D000328:Adult; D005260:Female; D006099:Granuloma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D007278:Injections, Spinal / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D009020:Morphine