Noncompetitive inhibitors of the acetylcholine receptor help paint a picture of its ion channel.
This review describes and analyzes the evidence from studies using noncompetitive inhibitors of the nicotinic acetylcholine receptor that the receptor's ion channel is formed by the second transmembrane segment of all five receptor subunits. Inconsistencies in this generally accepted model are also presented and discussed.
Eterovic
V A
VA
Department of Biochemistry and Nutrition, Universidad Central del Caribe, Bayamón, PR 00960-6032.
Hann
R M
RM
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002412:Cations / Q000378:metabolism; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D015640:Ion Channel Gating / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000494:pharmacology; D011487:Protein Conformation; D011950:Receptors, Cholinergic / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
D002412:Cations; D018680:Cholinergic Antagonists; D007473:Ion Channels; D009498:Neurotoxins; D011950:Receptors, Cholinergic