Hypovolaemic and osmotic stimuli induce distinct patterns of c-Fos expression in the rat subfornical organ.
Investigation of the effects of osmotic and hypovolaemic stimuli on the pattern of subfornical organ (SFO) c-fos expression yielded three distinct distributions of activated neurons. Hypertonic saline induced c-fos expression in peripheral SFO only. PEG/water induced c-fos in the central core of SFO and PEG/saline induced c-fos in both the central and peripheral regions. Isotonic saline failed to induce SFO c-fos expression. These results are consistent with the notion of functional segregation within the SFO.
Smith
D W
DW
Department of Physiology and Pharmacology, University of Queensland, St Lucia, Australia.
Day
T A
TA
D000818:Animals; D007274:Injections, Intraperitoneal; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009997:Osmotic Pressure; D010953:Plasma Volume; D011092:Polyethylene Glycols / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D013356:Subfornical Organ / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; D012462:Saline Solution, Hypertonic; D011092:Polyethylene Glycols