[Synthesis of retinoids with a modified polar group and their antitumor activity. Report I].
Several retinoids with modified polar group were synthesized. Biological screening using HL-60 promyelocyte leukemia cells showed that the free carboxyl in the retinoid molecules is not the only group responsible for exhibiting the differentiating activity.
Deriabina
E L
EL
Khodonov
A A
AA
Cherevataia
G V
GV
Kirillova
Iu G
IuG
Shvets
V I
VI
Kostanian
I A
IA
Astapova
M V
MV
Dranitsyna
S M
SM
Starovoĭtova
E V
EV
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D011487:Protein Conformation; D018168:Receptors, Retinoic Acid / Q000737:chemistry; D012176:Retinoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D018168:Receptors, Retinoic Acid; D012176:Retinoids