Endothelin-1, via activation of an ETB receptor, inhibits cholinergic nerve-mediated contractions in sheep trachea.
In this study, we have examined the neuromodulatory actions of endothelin (ET)-1 and related peptides on cholinergic nerve function in the airways. We and others have recently demonstrated that activation of prejunctional ETB receptors augments cholinergic-nerve mediated contractions in the airways of the rabbit and mouse. In contrast, the current study in sheep isolated trachea reveals that activation of prejunctional ETB receptors is associated with attenuation of electrical field stimulation (EFS)-induced, cholinergic nerve-mediated contractions.
Henry
P J
PJ
Department of Pharmacology, University of Western Australia, Nedlands, Australia.
Goldie
R G
RG
D000818:Animals; D004558:Electric Stimulation; D016232:Endothelins / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000187:drug effects / Q000502:physiology*; D012756:Sheep; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D016232:Endothelins; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin