title: Synthesis and antibacterial activity of substituted 4-arylaminopyrimido[5,4-c]cinnolines.
abstract: A series of 4-arylamino pyrimido[5,4-c]cinnolines was synthesized and evaluated for antibacterial activity by serial 2-fold dilution technique. Several compounds showed significant activity. Amongst them 7-methyl-4-[(p-methyl phenyl) amino] pyrimido [5,4-c] cinnoline (2f) was the most active against Gram positive bacteria.
authors.affiliation: Memorial Research Centre, Nargund College of Pharmacy, Banglore, India.
authors.forename: L V
authors.initials: LV
authors.lastname: Nargund
authors.forename: K S
authors.initials: KS
authors.lastname: Nargund
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines