title: A modified Two-BUN method for routine urea modeling: clinical validation in 120 patients on a free diet.
abstract: Recently, a modified algorithm of the Two-BUN method (MA2p), avoiding dialyzer clearance measurement, was presented for routine assessment of Kt/V and NPCR. To validate MA2p in patients on a free diet (FDP), we studied 120 stable dialysis FDP by measuring Kt/V and NPCR with both MA2p and a modified version of the standard Three-BUN method (MA3p), for the 3 weekly sessions. The NPCR values (g/kg/day), calculated by MA3p for the 3 interdialyses were: 1.286 +/- 0.274, 1.256 +/- 0.276, and 1.116 +/- 0.230, respectively. The correlation coefficient (r) for averaged Kt/V values obtained by the two methods was 0.999 and the percent error (Error%) for MA2p vs. MA3p results ranged from -1.5 to +0.78%. The respective results for NPCR were: r = 0.967, Error% range from -11.7 to +13.9%. In conclusion, MA2p can be safely used in patients on a free diet. The lowest NPCR values were observed during the long interdialysis.
authors.affiliation: Dialysis Unit, Ospedale Civile, Matera, Italy.
authors.forename: F G
authors.initials: FG
authors.lastname: Casino
authors.forename: C
authors.initials: C
authors.lastname: Lomonte
authors.forename: R
authors.initials: R
authors.lastname: Russo
authors.forename: B
authors.initials: B
authors.lastname: Di Iorio
authors.forename: G
authors.initials: G
authors.lastname: Chiarulli
authors.forename: C
authors.initials: C
authors.lastname: Manno
authors.forename: T
authors.initials: T
authors.lastname: Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000704:Analysis of Variance; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000502:physiology; D002482:Cellulose / Q000031:analogs & derivatives / Q000378:metabolism; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis / Q000592:standards*
chemical_list: D008567:Membranes, Artificial; D002482:Cellulose; C009865:cuprammonium cellulose