The effect of serum follicular phase luteinizing hormone concentrations in habitual abortion: correlation with results of paternal leukocyte immunization.
A prospective study was carried out on 153 couples with recurrent abortions who desired pregnancy. The object was to determine the incidence of raised luteinizing hormone (LH) levels; to compare the outcome of further pregnancies in habitually aborting women with and without raised circulating LH concentrations; and to assess whether the efficacy of paternal leukocyte immunization is affected in the presence of raised LH concentrations. Of the 153 women with recurrent abortions (> 3) included in this study, 56 (36.6%) had follicular phase serum LH concentrations > 10 mIU/ml. Of the 103 pregnancies that were followed prospectively, 65 (63.1%) resulted in a birth of a live infant. There was no significant relationship between the pregnancy outcome and LH concentrations. Women who underwent immunization with paternal leukocytes had significantly more live births (75.8%) than those who were not immunized (43.6%). However, the live birth rate was lower after paternal leukocyte immunization in the presence of raised LH concentrations or a raised LH/follicle stimulating hormone (FSH) ratio.
Carp
H J
HJ
Department of Obstetrics and Gynaecology, Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv, Israel.
Hass
Y
Y
Dolicky
M
M
Goldenberg
M
M
Mashiach
S
S
Rabinovici
J
J
D000026:Abortion, Habitual / Q000097:blood* / Q000628:therapy*; D000328:Adult; D001723:Birth Rate; D005260:Female; D005498:Follicular Phase; D006801:Humans; D007114:Immunization; D007167:Immunotherapy; D007962:Leukocytes / Q000276:immunology*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009994:Osmolar Concentration; D011247:Pregnancy; D011446:Prospective Studies
D007986:Luteinizing Hormone