[Changes in the indices of standing and walking in patients with infantile cerebral palsy under the influence of low doses of Nakom].
10 patients were treated with Nacom preparation (62.5 mg/daily in one dose in the morning). Both the feet support area during standing of one leg and the vertical component of support reactions were examined by the using EMED pedographic analyser (Germany-Japan). These indexes were analysed in patients before treatment, in patients treated with Nacom early--in a week after its withdrawal and after 1 months of Nacom administration. It was determined that support area of equinovarus feet was enlarged during the treatment due to the increase of the loading on the heel and the middle part of the feet. Meanwhile the support area of equinovarus feet was decreased as a consequence of loading alterations on foot inner side. The varus component of deformation turned out to be subjected most of all to Nacom action while the equinus one underwent less alterations and the valgus one has changed insignificantly. The improvement of dynamic characteristics of walking, support and pushing legs functions as well as of relations between support step periods phases was observed in all patients. The Nacom effect depended upon the type of initial feet deformation. The results obtained were explained in terms of decrease in influence of both tonic cervical reflexes and synergic tonic reactions on feet. That resulted in alterations in biomechanic and innervation components of static locomotor functions in infantile cerebral paralysis.
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D000293:Adolescent; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D002230:Carbidopa / Q000008:administration & dosage*; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D005684:Gait / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D011187:Posture / Q000502:physiology; D016138:Walking / Q000502:physiology
D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa