The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice.
Transgenic animals of the line 8 contain the WAP-SV-T transgene. Females of this line synthesise the SV40 T-antigen in mammary gland epithelial cells during pregnancy and the lactation period. All females are 'milk-less' and the offspring have to be nursed by foster mothers. The reason for this phenomenon is a premature apoptosis during late pregnancy. Nontheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females devlop breast cancer after the first lactation period.
Tzeng
Y J
YJ
Institut für Molekularbiologie und Biochemie der Freien Universität, Berlin, Germany.
Gottlob
K
K
Santarelli
R
R
Graessmann
A
A
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics / Q000502:physiology*; D017209:Apoptosis; D004847:Epithelial Cells; D005260:Female; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000502:physiology; D008325:Mammary Neoplasms, Experimental / Q000209:etiology; D051379:Mice; D008822:Mice, Transgenic; D008894:Milk Proteins / Q000235:genetics; D011247:Pregnancy; D011270:Pregnancy, Animal; D011401:Promoter Regions, Genetic
D000952:Antigens, Polyomavirus Transforming; D008894:Milk Proteins; C024471:whey acidic proteins