Synergy of iron in the toxicity and carcinogenicity of polychlorinated biphenyls (PCBs) and related chemicals.
In Ah-responsive C57BL/10ScSn mice a single dose of iron significantly potentiated the property of the polychlorinated biphenyl (PCB) mixture Aroclor 1254 to induce porphyria by inhibition at the uroporphyrinogen decarboxylase stage of hepatic haem biosynthesis. The induction of liver tumors and other lesions were also enhanced markedly by iron overload suggesting a link between porphyria and cancer. The cellular, molecular and biochemical processes involved have been investigated in attempts to explain these phenomena by an iron-catalysed 'oxidative stress' mechanism.
Smith
A G
AG
MRC Toxicology Unit, University of Leicester, UK.
Carthew
P
P
Clothier
B
B
Constantin
D
D
Francis
J E
JE
Madra
S
S
D000818:Animals; D001140:Aroclors / Q000633:toxicity; D020111:Chlorodiphenyl (54% Chlorine); D004357:Drug Synergism; D007501:Iron / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D017094:Porphyrias, Hepatic / Q000139:chemically induced*
D001140:Aroclors; D020111:Chlorodiphenyl (54% Chlorine); D011078:Polychlorinated Biphenyls; D007501:Iron