Atypical presentation of 4-aminopyridine overdose.
4-Aminopyridine (4-AP) is an investigational drug for the treatment of neurologic disorders including multiple sclerosis (MS). Until recently, relatively little was known about 4-AP toxicity in overdose; the only recorded cases involved neurologic symptoms ranging from mild parasthesias to tonic-clonic seizures. We report a case of accidental 4-AP overdose that resulted in continuous, dystonic, choreoathetoid-type movements that responded to treatment with standard anticonvulsant dosages of benzodiazepines.
Pickett
T A
TA
Department of Emergency Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada.
Enns
R
R
D015761:4-Aminopyridine / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D000328:Adult; D062787:Drug Overdose; D004421:Dystonia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy
D015761:4-Aminopyridine