title: [Cognitive disorders in the structure of endogenous depression in old age].
abstract: 31 aged inpatients (60-88 years) with major depressive episode (DSM-III-R) have been investigated in order to study the dynamics and reversion of cognitive disorders in late depression and their relation to the course and outcome of depressive phases. The dynamic evaluation was achieved by 4-times testing with HAM-D and MMSE within the phase. All patients had some cognitive disfunction at the crucial of the phase, which in most cases (90.3%) was completely reversible during the therapy. It was found that cognitive disorders were partly associated with depression and where party related to the aging processes. The degree of cognitive impairments at the crucial stage of the phase depended upon the severity (t = 0.73; p < 0.001) and complexity (t = 0.71; p < 0.001) of the depressive syndrome. It also correlated with the duration of active therapy (t = 0.53; p < 0.005) and quality of the following remission (t = 0.48; p < 0.01). The dynamic assessment of the cognitive disorders may be used for the differentiation of pure depression from the states with the beginning degenerative disease, for the prediction of the course and outcome of depression and response to the therapy.
authors.forename: O B
authors.initials: OB
authors.lastname: Iakovleva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012008:Recurrence; D014057:Tomography, X-Ray Computed