A novel chitinase inhibitor from a marine bacterium, Pseudomonas sp.
A new chitinase inhibitor, CI-4, was isolated from the culture broth of a marine bacterium Pseudomonas sp. IZ208. The structure of CI-4 was determined to be cyclo(L-Arg-D-Pro) by spectral studies and comparison with a synthetic sample. CI-4 showed inhibitory activity against chitinase.
Izumida
H
H
Marine Biotechnology Institute, Shimizu Laboratories, Shizuoka 424, Japan.
Imamura
N
N
Sano
H
H
D002688:Chitinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D011549:Pseudomonas / Q000145:classification / Q000378:metabolism*; D014871:Water Microbiology
D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; C098401:cyclo(Arg-Pro); D002688:Chitinases