[Ontogenetic expression of neurochordin D--a specific glycoprotein from human brain].
Neurochordins constitute a family of several immunologically interrelated nervous tissue glycoproteins occurring in the soluble protein fraction of the brain of all vertebrate species including human. The only exception is neurochordin D which, as it has been shown in the present study, is present in human brain but not in the brains of rats and chickens. Human neurochordin D is first detected in the brain at the age of 18 months and further persists through life. A highly purified neurochordin D preparation has been obtained by immunoaffinity chromatography combined with biochemical protein fractionation. Quantitative carbohydrate analysis revealed the presence of Gal, Man, GlcNAc, Fuc and GalNAc in the neurochordin D preparation. The sensitivity of neurochordin D to neuraminidase suggests the presence of sialic acids.
Preobrazhenskiĭ
A A
AA
Voronina
A S
AS
Kaliberda
E N
EN
Vovk
T S
TS
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002241:Carbohydrates / Q000032:analysis; D002645:Chickens; D002846:Chromatography, Affinity; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051381:Rats
D002241:Carbohydrates; D009419:Nerve Tissue Proteins