title: Clinico-pathological predictors of recurrence for acinic cell carcinoma.
abstract: The biological behaviour of acinic cell carcinomas, even if well differentiated, is unpredictable. We studied 45 patients with acinic cell carcinoma followed-up from 10 to 379 months (5 year recurrence-free and survival rate of 69% and 81% respectively), and compared clinico-pathological parameters with outcome. The presence of a predominately solid architecture was strongly associated with a poor outcome (P < 0.01) and this was the only independent prognostic variable when log rank testing was performed. Tumour size (> 2.75 cm) was a significant predictor of recurrent deep parotid lobe involvement, the presence of cervical nodal disease and lymphocytic infiltration, although not significant, factors showed a tendency towards recurrence. For acinic cell carcinoma, the predominant solid architecture would appear to be a strong predictor of recurrence.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Toronto Hospital, Ottawa, Canada.
authors.forename: C I
authors.initials: CI
authors.lastname: Timon
authors.forename: I
authors.initials: I
authors.lastname: Dardick
authors.forename: T
authors.initials: T
authors.lastname: Panzarella
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: G
authors.initials: G
authors.lastname: Ellis
authors.forename: P
authors.initials: P
authors.lastname: Gullane
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018267:Carcinoma, Acinar Cell / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010307:Parotid Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate; D016896:Treatment Outcome