HIV induces activation of phosphatidylinositol 4-kinase and mitogen-activated protein kinase by interacting with T cell CD4 surface molecules.
T cell surface CD4 molecules act as co-receptors that amplify the T cell receptor (TcR)/CD3-induced signal transduction by a mechanism that requires the interaction of CD4 with p56lck tyrosine kinase (Veillette et al.; Nature 1989 338:257). Here, we demonstrate that in the absence of TcR signaling, heat-inactivated HIV-1 (HIV-HI) also elicits a cascade of events generally considered to convey a positive signal, such as protein tyrosine phosphorylation, phosphatidylinositol 4-kinase and mitogen-activated protein kinase activation. These results contribute to understand better the control that HIV may exert on its own replication or on T cell apoptosis by modulating the activation status of its target cells through its interaction with T cell surface CD4 molecules.
Schmid-Antomarchi
H
H
INSERM U 364, Unité d'Immunologie Cellulaire et Moléculaire, Faculté de Médecine, Nice, France.
Benkirane
M
M
Breittmayer
V
V
Husson
H
H
Ticchioni
M
M
Devaux
C
C
Rossi
B
B
D019870:1-Phosphatidylinositol 4-Kinase; D017209:Apoptosis / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology / Q000378:metabolism*; D004789:Enzyme Activation / Q000276:immunology; D015497:HIV-1 / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000201:enzymology* / Q000276:immunology / Q000821:virology*; D014779:Virus Replication / Q000276:immunology
D015704:CD4 Antigens; D011494:Protein Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D019870:1-Phosphatidylinositol 4-Kinase; D020929:Mitogen-Activated Protein Kinase Kinases