title: Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy.
abstract: Comparison of mid- and near-infrared spectra of control and infarcted rat ventricular tissue reveals the presence of absorptions in infarcted tissue which are highly characteristics of collagen, indicating large scale deposition of type I collagen in the myocardium following infarction. These results demonstrate that IR spectroscopy may be used to rapidly monitor the modifications of the extracellular matrix associated with myocardial infarction.
authors.affiliation: Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Manitoba.
authors.forename: K
authors.initials: K
authors.lastname: Lui
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: M G
authors.initials: MG
authors.lastname: Sowa
authors.forename: H
authors.initials: H
authors.lastname: Ju
authors.forename: I M
authors.initials: IM
authors.lastname: Dixon
authors.forename: H H
authors.initials: HH
authors.lastname: Mantsch
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis* / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D006352:Heart Ventricles; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D003094:Collagen