Influence of injection site on the absorption of benzylpenicillin sodium in the dromedary.
Benzylpenicillin absorption was compared in four dromedaries following injection subcutaneously and at three different intramuscular sites (neck, semitendinous and gluteal muscles). The rate of absorption (t1/2ab and Tmax) was slower after subcutaneous compared to intramuscular injection, but the extent of absorption (AUC) was similar for both routes of administration. Following intramuscular injection, the data suggest that the extent of absorption was highest from the semitendinous site and lowest in the neck site. These results were discussed and compared to those reported in other species.
Oukessou
M
M
Department of Physiology and Therapeutics, Institute of Agronomy and Veterinary Medicine Hassan II, Rabat, Morocco.
D000042:Absorption; D000818:Animals; D002162:Camelus / Q000097:blood / Q000378:metabolism*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D010400:Penicillin G / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D010406:Penicillins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
D010406:Penicillins; D010400:Penicillin G