Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo.
The computational analysis data presented indicate a significant mechanistic association between the ability of a chemical to cause tubulin polymerization perturbation (TPP), via direct interaction with the protein, and the in vivo induction of micronuclei (MN). Since it is known that TPP is not a genotoxic event, the analyses suggest that the induction of MN by a non-genotoxic mechanism is a significant alternate pathway.
ter Haar
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Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
Day
B W
BW
Rosenkranz
H S
HS
D000465:Algorithms; D000818:Animals; D002470:Cell Survival; D004247:DNA / Q000187:drug effects; D006801:Humans; D007256:Information Systems; D046911:Macromolecular Substances; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology* / Q000633:toxicity; D012475:Salmonella / Q000187:drug effects; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*
D046911:Macromolecular Substances; D009153:Mutagens; D014404:Tubulin; D004247:DNA