Lymphomatoid papulosis followed by Ki-1 positive anaplastic large cell lymphoma: proliferation of a common T-cell clone.
We report a case of lymphomatoid papulosis (LyP) followed by Ki-1 positive anaplastic large cell lymphoma (LCL). A 33-year-old man developed subcutaneous nodules in the left inguinal region and the left thigh after a seven-year-history of self-healing papulonecrotic lesions of LyP. Histological and immunohistochemical examination of the subcutaneous nodules revealed LCL. DNA was isolated from a nodule of the initial stage of LyP in 1988, a subcutaneous nodule of LCL in 1993, and a papule of LyP in 1993 which appeared after chemotherapy for LCL. T cell receptor gene rearrangement analysis demonstrated an identical rearranged pattern in all the three specimens, indicating that a common T cell clone proliferated throughout the course in both the LyP and LCL lesions.
Amagai
M
M
Dermatology Division, Tokyo Electric Power Hospital, Japan.
Kawakubo
Y
Y
Tsuyuki
A
A
Harada
R
R
D000328:Adult; D000708:Anaplasia; D002455:Cell Division; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006119:Groin; D006801:Humans; D007150:Immunohistochemistry; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000235:genetics / Q000473:pathology*; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology*; D013848:Thigh
D004273:DNA, Neoplasm