Primary gastric lymphoma: a 15-year review.
OBJECTIVE
Between 1976 and 1991, 25 patients underwent surgical therapy for primary gastric lymphoma. Clinical records were reviewed retrospectively to evaluate prognostic factors and impact of treatment on survival.


RESULTS
Diagnostic sensitivity of endoscopic biopsy was 68%, positively of barium contrast studies for tumor was 33%. The overall 5-year survival rate was 67.3% (51.7% "free disease"): it was for stage I E 88.9%, for stages II 1E and II 2E respectively 68.6% and 44.4% and for stage IV 33.4%. Patients with tumors smaller than 5 cm had a 5-year survival rate of 80.8% whereas for patients with larger lesions survival rate was 44% (p < 0.05). Patients with low grade malignancy tumors had a 5-year survival rate of 81.9% versus 37.5% for high grade malignancy tumors (p < 0.03). Chemotherapy as adjuvant therapy was used in 17 cases (68%). 53% of them are "free disease" at minimum 4 years from the operation.


CONCLUSIONS
We conclude that, surgical management of primary gastric lymphoma is mandatory but a planned multimodality therapy may produce complete remission and long-term "free disease" survival rate even in patients with relapse.
Speranza
V
V
Cattedra di Clinica Chirurgica II, University of Rome La Sapienza, Italy.
Lomanto
D
D
Meli
E Z
EZ
Basoli
A
A
Carlei
F
F
Ligydakis
N J
NJ
Lezoche
E
E
D000328:Adult; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate