title: Genetic control of susceptibility to Taenia crassiceps cysticercosis.
abstract: We previously reported that genes within the major histocompatibility complex influence the intensity of Taenia crassiceps murine cysticercosis. This genetic control, readily apparent in mice of BALB background, was further studied in H-2 congenic and recombinant B10 mice as well as in BALB/c substrains differing in expression of Qa-2 antigens. Similarly low parasite numbers were found in all B10-derived strains infected, regardless of H-2 haplotype, indicating that the effect of H-2 genes in controlling susceptibility is overridden in mice of B10 background. BALB/c substrains differed significantly in susceptibility. BALB/cAnN was highly susceptible, whereas BALB/cJ, in contrast, was highly resistant and BALB/cByJ showed intermediate susceptibility. Susceptibility or resistance in BALB/c substrains may be associated to differences known to distinguish them, such as serum testosterone levels and Qa-2 protein expression. In bidirectional F1 hybrids of C57BL/6J and BALB/cAnN resistance to cysticercosis was inherited as a dominant autosomal trait. In F1 hybrids of BALB/cJ with BALB/cAnN, BALB/cByJ and BALB.K resistance was also inherited as a dominant trait. However, in (BALB/cAnN x BALB/cByJ)F1 and (BALB/cAnN x BALB.K)F1 hybrids, dominant susceptibility to cysticercosis was observed.
authors.affiliation: Department of Immunology, Instituto de Investigaciones Biomédicas, UNAM, México, D.F. México.
authors.forename: G
authors.initials: G
authors.lastname: Fragoso
authors.forename: E
authors.initials: E
authors.lastname: Lamoyi
authors.forename: A
authors.initials: A
authors.lastname: Mellor
authors.forename: C
authors.initials: C
authors.lastname: Lomeli
authors.forename: T
authors.initials: T
authors.lastname: Govezensky
authors.forename: E
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000818:Animals; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006183:H-2 Antigens / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013621:Taenia / Q000276:immunology*; D013622:Taeniasis / Q000276:immunology*
chemical_list: D006183:H-2 Antigens