title: [Study on CCK-induced gallbladder emptying with real-time ultrasonography].
abstract: In the present study, we adopted real-time ultrasonography to investigate the effect of atropine on the gallbladder emptying induced by CCK-OP in the normal subjects, and the difference of gallbladder emptying induced by CCK-OP between the "silent" gallstone patients and the controls. The results showed that: (a) CCK-induced gallbladder emptying in normal subjects was inhibited from 88.7% +/- 5.5% without atropine to 43.4% +/- 9.4% with atropine (P < 0.001). (b) The fasting gallbladder volume in the "silent" gallstone patients (26.7 +/- 10.9cm3) was significantly larger than that in the control (19.2 +/- 7.3cm3) (P < 0.05) and gallbladder emptying in the "silent" gallstones patients (44.0% +/- 8.7%) was significantly lower than that in the control (53.4% +/- 6.4%) (P < 0.01). We concluded that, significantly inhibited CCK-induced gallbladder emptying and there was significantly impaired gallbladder emptying in the patients with gallstones.
authors.affiliation: Department of Gastroenterology, People's Hospital, Beijing Medical University.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: X
authors.initials: X
authors.lastname: Miao
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016473:Gallbladder Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D012844:Sincalide / Q000494:pharmacology; D014463:Ultrasonography
chemical_list: D005765:Gastrointestinal Agents; D018727:Muscarinic Antagonists; D001285:Atropine; D002766:Cholecystokinin; D012844:Sincalide