title: Cure, morbidity, and mortality associated with embolization of brain arteriovenous malformations: a review of 1246 patients in 32 series over a 35-year period.
abstract: Published reports of cure, morbidity, and mortality associated with the embolization of 1246 brain arteriovenous malformations during the last 35 years were reviewed. Embolization resulted in cure in 5% of arteriovenous malformations. The cure rates of embolization were 4% in reports of 708 patients published before 1990 and 5% in reports of 538 patients published since 1990 (P = not significant). Temporary morbidity from embolization was 10%, and permanent morbidity was 8%. Permanent morbidity was 9% before 1990 and 8% since 1990 (P = not significant). Death after embolization of brain arteriovenous malformations occurred in 1% of patients. Mortality associated with the embolization was 2% before 1990 and 1% since 1990 (P = not significant). Long-term morbidity associated with the use of neurotoxic embolization materials is worrisome but has never been proven.
authors.affiliation: Division of Neurosurgery, University of Alabama at Birmingham, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Frizzel
authors.forename: W S
authors.initials: WS
authors.lastname: Fisher
mesh_terms: D002015:Bucrylate / Q000009:adverse effects; D002423:Cause of Death; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000401:mortality; D004659:Enbucrilate / Q000009:adverse effects; D004867:Equipment Design; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000401:mortality* / Q000628:therapy*; D011142:Polyvinyl Alcohol / Q000009:adverse effects; D012307:Risk Factors; D015996:Survival Rate; D014014:Tissue Adhesives / Q000009:adverse effects
chemical_list: D014014:Tissue Adhesives; D002015:Bucrylate; D011142:Polyvinyl Alcohol; D004659:Enbucrilate