title: Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix.
abstract: The polymerase chain reaction has been used to determine the presence of human papillomavirus (HPV) 16 and HPV 18 DNA sequences in archival histological material removed from a cohort of untreated women with cervical epithelial abnormalities. The detection of HPV 16 or HPV 18 DNA sequences in the initial biopsy specimen was associated with a significantly increased risk of subsequent disease progression.
authors.affiliation: Centre for Cancer Epidemiology, Christie Hospital NHS Trust, Manchester, UK.
authors.forename: C B
authors.initials: CB
authors.lastname: Woodman
authors.forename: T
authors.initials: T
authors.lastname: Rollason
authors.forename: J
authors.initials: J
authors.lastname: Ellis
authors.forename: R
authors.initials: R
authors.lastname: Tierney
authors.forename: S
authors.initials: S
authors.lastname: Wilson
authors.forename: L
authors.initials: L
authors.lastname: Young
mesh_terms: D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D013997:Time Factors; D014412:Tumor Virus Infections / Q000150:complications* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000821:virology*
chemical_list: D004279:DNA, Viral