title: Prospective study of autonomic nerve function in type 1 and type 2 diabetic patients: 24 hour heart rate variation and plasma motilin levels disturbed in parasympathetic neuropathy.
abstract: To clarify the impact of autonomic neuropathy in diabetic patients, we have conducted a prospective study of 58 Type 1 and 51 Type 2 diabetic patients (investigated at baseline, after 4, and after 7 years). In Type 1 diabetic patients, the sympathetic nerve function (orthostatic acceleration and brake indices) and in Type 2 patients, parasympathetic nerve function (R-R interval variation; E/l ratio) deteriorated during 7 years of prospective observation. Symptoms of autonomic neuropathy were associated with signs of autonomic neuropathy (low brake indices) in Type 1 but not in Type 2 diabetic patients. In the latest assessment 24 h ECG recording was performed and blood samples assayed for neuropeptide Y (NPY) and motilin were obtained. Type 1 diabetic patients with parasympathetic neuropathy (abnormal E/l ratio) showed significantly lower SD value (less variation in the R-R intervals; 29 [17] vs 50 [16], [mean (interquartile range)]; p = 0.001) and higher postprandial plasma motilin values (70 [20] pmol l-1 vs 50 [15] pmol l-1; p < 0.01) than patients with normal parasympathetic nerve function. In Type 2 diabetic patients, sympathetic neuropathy (low brake indices) was associated with an increased frequency of ventricular extra systolic beats during 24 h ECG recording (rs = 0.65; p < 0.01). Postprandial plasma NPY levels were not associated with disturbed autonomic nerve function.
authors.affiliation: Department of Endocrinology, University of Lund, Malmö University Hospital, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Nilsson
authors.forename: B
authors.initials: B
authors.lastname: Bergström
authors.forename: B
authors.initials: B
authors.lastname: Lilja
authors.forename: S
authors.initials: S
authors.lastname: Juul-Möller
authors.forename: J
authors.initials: J
authors.lastname: Carlsson
authors.forename: G
authors.initials: G
authors.lastname: Sundkvist
mesh_terms: D000293:Adolescent; D000328:Adult; D017776:Autonomic Pathways / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000097:blood*; D009478:Neuropeptide Y / Q000097:blood; D011446:Prospective Studies
chemical_list: D009478:Neuropeptide Y; D009037:Motilin