title: [Synthesis of new platelet aggregation inhibitors substituted with pyridylisoxazoles and their 4,5-dihydroanalogs].
abstract: A number of substituted pyridylisoxazoles and their 4,5-dihydro analogs were synthesized by 1,3-dipolar cycloaddition of substituted nitrile oxides to either alkenes or alkynes. The synthesized compounds inhibit arachidonic acid-induced aggregation of human thrombocytes at concentrations of 10(-6) to 10(-3) M. Due to low toxicity, these compounds can be regarded as potential antithrombosis medicines.
authors.forename: O V
authors.initials: OV
authors.lastname: Demina
authors.forename: P V
authors.initials: PV
authors.lastname: Vrzheshch
authors.forename: A A
authors.initials: AA
authors.lastname: Khodonov
authors.forename: V I
authors.initials: VI
authors.lastname: Kozlovskiĭ
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeev
mesh_terms: D016718:Arachidonic Acid / Q000502:physiology; D006801:Humans; D010080:Oxazoles / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010080:Oxazoles; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid