title: Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis.
abstract: Agranulocytosis and septicaemia developing in a patient with rheumatoid arthritis after 3 years' intermittent treatment with diclofenac, cimetidine and flucloxacillin for staphylococcal osteomyelitis is described. Treatment with recombinant granulocyte-colony-stimulating factor and high-dose methylprednisolone had no effect on the neutropenia which resolved on stopping all drug therapy. Relapse of agranulocytosis followed reintroduction of flucloxacillin and cimetidine 3 months later.
authors.affiliation: Department of Haematology, University Hospital of South Manchester, UK.
authors.forename: I E
authors.initials: IE
authors.lastname: Burton
authors.forename: K M
authors.initials: KM
authors.lastname: Moussa
authors.forename: P A
authors.initials: PA
authors.lastname: Sanders
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D001172:Arthritis, Rheumatoid / Q000150:complications*; D002927:Cimetidine / Q000627:therapeutic use; D005260:Female; D005436:Floxacillin / Q000009:adverse effects* / Q000627:therapeutic use; D019084:Fluorescent Antibody Technique, Indirect; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D008775:Methylprednisolone / Q000627:therapeutic use; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D010406:Penicillins / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy*
chemical_list: D010406:Penicillins; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D005436:Floxacillin; D002927:Cimetidine; D008775:Methylprednisolone