[The modulating effect of the thyrotropin-releasing hormone on genetically induced mechanisms of morphine sensitivity].
The influence of thyrotropin-releasing hormone (TRH) on morphine-induced analgesic and reinforced responses was studied in two inbred strains of rats, Fischer-344 (F344) and Wistar Albino Glaxo/GSto (WAG). Conditioned place preference, voluntary consumption of morphine solution and analgesic action of morphine in tail immersion test were studied. There were interstrain differences in pain sensitivity, i.e., F344 rats had longer latency of tail immersion and deeper analgesic effect of morphine (5 mg/kg, ip) than WAG rats. TRH (1 mg/kg, ip) produced a stronger analgesic effect in WAG rats, while F344 rats demonstrated only slight increase in pain threshold. Administration of TRH in combination with morphine significantly stronger potentiated the effect of the latter in WAG than in F344 rats. F344 rats preferred morphine in the two-bottle choice test and consumed relatively larger amount of morphine solution in the drinking paradigm than WAG rats. Morphine in the dose of 5 mg/kg (ip) induced place preference in both rat strains. Intraventricular administration of TRH (1 mcg) produced a slight effect of place preference only in F344 rats. Preceded by morphine, such injection reduced the effect of place preference. It is suggested that WAG and F344 rats have different sensitivity of brain structures to TRH. This is probably determined by genetic differences in dissociation of analgesic and reinforcing effects of morphine.
Borisova
E V
EV
Sudakov
S K
SK
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004361:Drug Tolerance; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012054:Reinforcement, Psychology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
D009294:Narcotics; D013973:Thyrotropin-Releasing Hormone; D009020:Morphine; D011803:Quinine