Cyclosporine A stimulates endothelin release.
Administration of cyclosporine A is often associated with the development of renal dysfunction and hypertension. Because recent data provide evidence that endothelin (ET) might be involved in mediating cyclosporine-associated cardiovascular and renal side effects, the present study aimed to investigate the influence of cyclosporine A on ET release from cultured smooth-muscle cells and whether ET plasma concentrations are elevated in cyclosporine-treated patients. Addition of cyclosporine A to the medium of cultured human smooth-muscle cells, isolated from atherosclerotic iliac arteries, induced a dose-dependent increase in ET release. ET plasma levels were significantly elevated in cyclosporine-treated patients after bone marrow transplantation, compared to control groups. These data suggest that enhanced ET release might be involved in mediating the cyclosporine-associated side effects.
Haug
C
C
Institute of Clinical Chemistry, University of Ulm, Germany.
Duell
T
T
Voisard
R
R
Lenich
A
A
Kolb
H J
HJ
Mickley
V
V
Hombach
V
V
Grünert
A
A
D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology*; D016232:Endothelins / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism
D016232:Endothelins; D007166:Immunosuppressive Agents; D016572:Cyclosporine