Detection of renal ischemic lesions using Gd-DTPA enhanced turbo FLASH MRI: experimental and clinical results.
OBJECTIVE
Our goal was to investigate the role of Gd-DTPA-enhanced dynamic MRI in the evaluation of renal ischemic lesions.


METHODS
With a turbo FLASH sequence before and after injection of Gd-DTPA, nine foxhound dogs after 60-120 min of renal ischemia underwent MR examination. In addition, five patients with a tumor in a solitary kidney were examined before and after nephron-sparing renal surgery to evaluate renal perfusion and function. The experimental and clinical findings were correlated with conventional measurements of kidney function and with histological findings.


RESULTS
Complete renal ischemia leads to a poor corticomedullary differentiation in Gd-DTPA-enhanced turbo FLASH MRI. The signal-intensity-versus-time plots of kidneys with significant postischemic changes show a less steep increase of signal intensity in the cortex and a steeper increase of signal intensity in the medulla than those of normal kidneys.


CONCLUSIONS
Dynamic MRI demonstrate renal morphology and reflect the functional status of renal vasculature.
Vosshenrich
R
R
Department of Radiology, University of Göttingen, Germany.
Kallerhoff
M
M
Gröne
H J
HJ
Fischer
U
U
Funke
M
M
Kopka
L
L
Siebert
G
G
Ringert
R H
RH
Grabbe
E
E
D000368:Aged; D000818:Animals; D003287:Contrast Media; D004285:Dogs; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007511:Ischemia / Q000175:diagnosis*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007680:Kidney Neoplasms / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA