title: Effective treatment of drug-induced agranulocytosis using recombinant human granulocyte colony stimulating factor in pregnancy.
abstract: Drug-induced immune system mediated agranulocytosis is a rare but potentially life-threatening condition. There have been only a few reports on the drug-induced agranulocytosis during pregnancy. We present a case of agranulocytosis after prolonged intravenous infusion of ritodrine hydrochloride and additional administration of indomethacin suppositories, effectively treated using recombinant human granulocyte colony stimulating factor without any infection in a mother with twin-to-twin transfusion syndrome. Recombinant human granulocyte colony stimulating factor may have a potential use for drug-induced agranulocytosis during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Simane Medical University, Izumo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Fujiwaki
authors.forename: T
authors.initials: T
authors.lastname: Hata
authors.forename: K
authors.initials: K
authors.lastname: Hata
authors.forename: M
authors.initials: M
authors.lastname: Kitao
authors.forename: H
authors.initials: H
authors.lastname: Furuya
authors.forename: Y
authors.initials: Y
authors.lastname: Katoh
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000592:standards / Q000627:therapeutic use*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007262:Infusions, Intravenous; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000592:standards / Q000627:therapeutic use; D012312:Ritodrine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013488:Suppositories; D015149:Tocolytic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D013488:Suppositories; D015149:Tocolytic Agents; D016179:Granulocyte Colony-Stimulating Factor; D012312:Ritodrine; D007213:Indomethacin