[A case of itraconazole-induced hypokalemia with pulmonary aspergilloma].
A case of itraconazole-induced hypokalemia with pulmonary aspergilloma is reported. A 68-year-old female who had been followed for rheumatoid arthritis, gastric ulcer and pulmonary aspergilloma was admitted to our hospital because of a cough, low grade fever and hemosputum. She was treated with itraconazole (100 mg/day) for pulmonary aspergilloma of the left upper lobe. Fifty seven days after starting the treatment, her serum potassium was 2.33 mEq/l. Since there was no history of diarrhea, vomiting or abuse of drugs known to cause hypokalemia, itraconazole- induced hypokalemia was suspected. Thirty one days after the discontinuation of the treatment with itraconazole, her serum potassium increased to 3.57 mEq/l without potassium supplement. The lymphocyte stimulation test for itraconazole was negative. This case suggests that serum potassium should be monitored in the patients treated with itraconazole.
Yamamoto
T
T
Department of Internal Medicine, Nagoyashi-Koseiin Geriatric Hospital.
Suzuki
K
K
Yamakoshi
M
M
Yamamoto
T
T
Ariga
K
K
D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced*; D017964:Itraconazole / Q000009:adverse effects*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*
D000935:Antifungal Agents; D017964:Itraconazole