Hypervitaminosis A as a complication of treatment for neuroblastoma.
A case of hypervitaminosis A (HVA) as a complication of therapy for stage-IV neuroblastoma is presented. The patient was randomized to a trial of 13-cis -retinoic acid (a vitamin A-related compound) after completing routine chemotherapy. This acid was given as a means of maturing potential minimal residual disease. A routine follow-up bone scan revealed areas of increased activity, initially along the midshaft of the right ulna and subsequently bilaterally, which were ultimately found to be due to HVA. Hypervitaminosis A has not been previously reported in this setting, and awareness of the condition is important in centers where this treatment is contemplated.
Grissom
L E
LE
Department of Medical Imaging, Alfred I. duPont Institute, 1600 Rockland Road, Wilmington, DE 19803, USA.
Griffin
G C
GC
Mandell
G A
GA
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002675:Child, Preschool; D006801:Humans; D006986:Hypervitaminosis A / Q000000981:diagnostic imaging / Q000209:etiology*; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy*; D011859:Radiography
D015474:Isotretinoin