Antioxidative role of ocular melanin pigment in the model of lens induced uveitis.
Ocular melanin pigment has antioxidant effect against excess of dispersed light. To investigate whether it has a similar effect in ocular inflammations, we used albino and pigmented guinea pigs and measured retinal glutathione peroxidase activities and lipid peroxide levels (expressed as thiobarbituric acid reactive substances) in a model of lens induced uveitis. Although the increase in the levels of the retinal lipid peroxides were higher in the albino group (204%, p < 0.05), the decrease in the activities of glutathione peroxidase were higher in pigmented guinea pigs (26%, p < 0.005). The results of the study suggest that pigmentless animals are more sensitive to the ocular inflammations, and ocular melanin pigment may act as an endojen antioxidant in lens induced uveitis.
Bilgihan
A
A
Department of Biochemistry, University of Gazi, Medical Faculty, Anakara, Turkey.
Bilgihan
M K
MK
Akata
R F
RF
Aricioğlu
A
A
Hasanreisoğlu
B
B
D000818:Animals; D000975:Antioxidants; D003459:Crystallins / Q000276:immunology; D004195:Disease Models, Animal; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000378:metabolism; D006168:Guinea Pigs; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism; D008543:Melanins / Q000502:physiology*; D012160:Retina / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014605:Uveitis / Q000276:immunology / Q000378:metabolism*
D000975:Antioxidants; D003459:Crystallins; D005609:Free Radicals; D008054:Lipid Peroxides; D008543:Melanins; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase