Non-invasive detection of ibuprofen in vivo 13C-NMR signals in rats.
A non-invasive in vivo 13C-NMR experiment is performed to follow the metabolic pathway of ibuprofen in rats. Detection of possible intermediates and the stereoselectivity of ibuprofen chiral inversion process are discussed.
Chen
C N
CN
Biomedical Engineering & Instrumentation Program, NCRR, NIH, Bethesda, MD, USA.
Wang
P C
PC
Song
H F
HF
Liu
Y C
YC
Chen
C S
CS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D002247:Carbon Isotopes; D005240:Feasibility Studies; D007052:Ibuprofen / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002247:Carbon Isotopes; D007052:Ibuprofen