[Borderline mental disorders in parkinsonism patients and their drug correction].
70 patients with vascular parkinsonism (VP) were investigated. The total group of patients was divided into several groups depending upon: a) the forms of disease (with typical or atypical forms of disease), b) the different syndromes (with bradykinesia and rigidity or tremor). Borderline psychic disorders manifested as a light depression with cognitive disturbances and personality changes. Hamilton Depression Rating Scale and Hachinski Ischemic Score were administered to assess the severity of depression and cognitive disturbances, respectively. Patients were treated with cholinolytics and L-DOPA-containing preparations. After treatment the clinical improvements were observed in patients with typical (86.8%) and atypical (93.7%) forms of VP (difference between groups failed to reach statistical significance), with tremor (93.3%) and rigidity (83.7%) syndromes (difference between groups reached statistical significance, p < 0.05). Efficacy of antidepressant treatment reached 90.5% in patients with typical and in 100% atypical forms of VP, respectively. The efficacy was the same in patients with rigid forms of VP. Antidepressant treatment significantly elevated the level of social adaptation of patients with VP.
Kamenetskiĭ
V K
VK
Sadov
O G
OG
D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001883:Borderline Personality Disorder / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D002908:Chronic Disease; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D012917:Social Adjustment
D000928:Antidepressive Agents; D000978:Antiparkinson Agents