[Photodynamic therapy of small adenocarcinomas with methylene blue].
Photodynamic therapy (PDT) is a new method in the treatment of small/early malignancies. It is based on the interaction of a photosensitiser, light and cellular oxygen. A new therapeutic concept with locally applied 1% of methylene blue into the tumour and subsequent radiation (argon laser pumped dye laser, 665 nm, 100 mW/cm2, 100 J/cm2) was first tested in xeno-transplanted carcinomas and then clinically applied. The animal experiments showed a tumour volume reduction of 1:12, as compared to a control group, two weeks after the first PDT-application. After the second PDT-treatment 6 out of 10 tumours were destroyed. Four carcinomas showed inhibited growth after the treatment. The method was clinically applied in 3 patients with local tumour recurrence in the area of the anastomosis after oesophagus resection. 72 hours after PDT-treatment 4-5 mm tumour necrosis could be proven experimentally. PDT was repeated at the same site within 2 weeks. There were no experimental or clinical complications during or after PDT. The treated tumour areas showed no local tumour growth within 6 months after PDT-treatment.
Orth
K
K
Chirurgische Klinik I, Universität Ulm.
Rück
A
A
Beck
G
G
Stanescu
A
A
Beger
H G
HG
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation; D010778:Photochemotherapy / Q000379:methods*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D008751:Methylene Blue