Aspiration cytology of a case of tumoral calcinosis.
The fine-needle aspiration (FNA) cytologic findings in a case of non-familial tumoral calcinosis are described. These include abundant calcific amorphous deposits, mononuclear histiocytes, osteoclast-type multinucleated giant cells, and fragments of tissue consisting of osteoblast-type cells with atypical epithelial-like features mimicking an epithelial malignancy. This is the first reported case describing the cellular morphology of tumoral calcinosis in an FNA specimen. A previously reported case described the evacuation of acellular calcific fluid only. In the present case, vigorous aspiration of the solid portions of the lesion yielded cellular material representative of the histology of the lesion. Points of caution for a correct interpretation of the cytologic findings are discussed.
Zaharopoulos
P
P
Department of Pathology, University of Texas Medical Branch, Galveston 77550, USA.
Di Patre
P L
PL
D001707:Biopsy, Needle; D002114:Calcinosis / Q000150:complications / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000150:complications; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology