title: Survival after AIDS among Italian haemophiliacs with HIV infection. The Italian Group on Congenital Coagulopathies.
abstract: OBJECTIVE
  To estimate survival trends for persons with haemophilia and HIV/AIDS.
  
  
  METHODS
  Survival analysis conducted among the cohort of HIV-positive haemophiliacs with AIDS at the Italian Haemophilia Registry. Kaplan-Meier method was used to estimate survival times, stratifying for demographic and clinical covariates. Cox proportional hazards model was applied in order to identify factors independently associated with survival.
  
  
  RESULTS
  Median survival from the first AIDS diagnosis to death was estimated to be 17.0 months for 176 individuals with AIDS. Median survival after AIDS diagnosis increased from 12.0 months in December 1983-December 1988 to 17.0 months in January 1989-May 1990 and to 25.0 months in June 1990-December 1991. Median survival times were significantly (P < 0.001) lower for individuals diagnosed with non-infective AIDS indicator diseases (lymphoma, AIDS-associated neurological disease, Kaposi's sarcoma, wasting syndrome: 4.0 months), in comparison with haemophiliacs diagnosed with Pneumocystis carinii pneumonia (PCP; 18.0 months) or other infections (35.0 months). Antiretroviral treatment after AIDS diagnosis was associated with a longer survival than that estimated for individuals with no treatment after AIDS; the same was true for PCP prophylaxis. Younger age at HIV seroconversion and at AIDS diagnosis were associated with a longer survival. Multivariate analysis showed that factors independently associated with survival were type of AIDS indicator disease and antiretroviral administration after AIDS diagnosis.
  
  
  CONCLUSIONS
  This study indicates an increasing survival from AIDS diagnosis to death over time, also as a result of the introduction of antiretroviral therapy. Survival trends are similar to those reported among homosexual men and intravenous drug users with AIDS, suggesting a similar access to the health-care system for individuals with AIDS. Survival studies may improve our understanding of the natural history of HIV infection and may indicate the impact of preventive measures.
authors.affiliation: Laboratory of Epidemiology and Biostatistics, National Institute of Health, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ghirardini
authors.forename: M
authors.initials: M
authors.lastname: Puopolo
authors.forename: G
authors.initials: G
authors.lastname: Rossetti
authors.forename: G
authors.initials: G
authors.lastname: Mancuso
authors.forename: L
authors.initials: L
authors.lastname: Perugini
authors.forename: G
authors.initials: G
authors.lastname: Piseddu
authors.forename: F
authors.initials: F
authors.lastname: Chiarotti
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology / Q000401:mortality*; D015331:Cohort Studies; D005069:Evaluation Studies as Topic; D006467:Hemophilia A / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D015999:Multivariate Analysis; D016019:Survival Analysis