title: Magnetization transfer in hemopoietic bone marrow examined by localized proton spectroscopy.
abstract: The sensitivity of hemopoietic bone marrow to magnetization transfer is analyzed in 15 healthy volunteers and seven patients with different hematological disorders (inflammation, plasmacytoma, hemopoietic reconstitution after bone marrow transplantation). To obtain sufficient signal-to-noise ratio, a 90 degrees - 180 degrees - 180 degrees double spin echo (PRESS) single voxel spectroscopic method was combined with pulsed magnetization transfer. Several spectra were recorded from each volume element inside the vertebral marrow, alternately with and without prepulses for magnetization transfer. Water signals from marrow with increased content of extracellular water due to inflammation or edema revealed less magnetization transfer effects than marrow with increased intracellular water content due to high cellularity. The preliminary results show magnetization transfer to be a promising tool for the clinically important characterization of the water composition in red bone marrow.
authors.affiliation: Institute of Physics, University of Tübingen, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Schick
authors.forename: J
authors.initials: J
authors.lastname: Forster
authors.forename: H
authors.initials: H
authors.lastname: Einsele
authors.forename: B
authors.initials: B
authors.lastname: Weiss
authors.forename: O
authors.initials: O
authors.lastname: Lutz
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001834:Body Water / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D016026:Bone Marrow Transplantation; D005260:Female; D006402:Hematologic Diseases / Q000378:metabolism*; D006410:Hematopoiesis; D006801:Humans; D008159:Lumbar Vertebrae / Q000033:anatomy & histology / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged