[Insulin receptor].
The cloning of the insulin receptor not only established the primary structure of this membrane-bound glycoprotein but also offered the material necessary for the study of the molecular functions of this tyrosine-kinase receptor using molecular biology tools. This short review will summarize the actual knowledge of the structure, the functions (molecular structure of the binding site, tyrosine-kinase functions and role of autophosphorylation) and of the pathology of this receptor in extreme insulin resistances and type II diabetes.
Clauser
E
E
INSERM U36, Collége de France, Paris.
Auzan
C
C
Leconte
I
I
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D011972:Receptor, Insulin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D011972:Receptor, Insulin