title: Contractile proteins in human fetoplacental vessels.
abstract: OBJECTIVE
  Our purpose was to compare the protein isoform composition of the contractile apparatus at different levels of the fetoplacental vessel musculature at term.
  
  
  METHODS
  Umbilical, chorionic, and stem villi vessel protein extracts were run on one- and two-dimensional gel electrophoresis; previously characterized human myometrium proteins were used as the smooth muscle proteins of reference.
  
  
  RESULTS
  Fetoplacental vessel musculature exhibited a high actin/myosin ratio. The presence, in varying quantities, of myosin heavy chain and actin isoforms of smooth muscle type in the different vessels reflected their degree of differentiation. The presence of nonmuscle protein isoforms, particularly in stem villi vessels, indicated a certain degree of immaturity.
  
  
  CONCLUSIONS
  The presence of smooth muscle contractile protein isoforms indicates that fetoplacental vessel musculature is highly differentiated. Regional modulation of fetoplacental blood flow could be, in part, the result of local differences in contractile apparatus protein composition.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Cavaillé
authors.forename: A
authors.initials: A
authors.lastname: Kacémi
authors.forename: F
authors.initials: F
authors.lastname: Mondon
authors.forename: T
authors.initials: T
authors.lastname: Fournier
authors.forename: F
authors.initials: F
authors.lastname: Ferré
mesh_terms: D000199:Actins / Q000032:analysis* / Q000737:chemistry; D001158:Arteries / Q000737:chemistry; D002823:Chorion / Q000098:blood supply*; D002824:Chorionic Villi / Q000098:blood supply; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D009124:Muscle Proteins / Q000032:analysis / Q000737:chemistry; D009218:Myosins / Q000032:analysis* / Q000737:chemistry; D014469:Umbilical Arteries / Q000737:chemistry*; D014471:Umbilical Veins / Q000737:chemistry*; D014680:Veins / Q000737:chemistry
chemical_list: D000199:Actins; D009124:Muscle Proteins; D009218:Myosins