Endotoxin induced cellular communication in the liver: murine models for clarification of the role of LPS-responsive macrophages in the pathogenesis of liver diseases.
In several experimental models, lipopolysaccharide (LPS) plays an important role in the pathogenesis of liver diseases. Murine models of C3H/HeN and C3H/HeJ mice have been used to elucidate the role of LPS and its responsive-macrophages in vivo, as C3H/HeN strain mice are known to be LPS-responsive, while C3H/HeJ strain mice are LPS-resistant. Furthermore, release of several kinds of biologically active mediators such as interleukin-1, tumour necrosis factor-alpha, colony stimulating factor and reactive oxygen radical is not enhanced in C3H/HeJ mice even after stimulation with LPS. Thus, these murine models could be suitable for clarification of endotoxin induced cellular communication in the liver.
Shiratori
Y
Y
Department of Internal Medicine (II), Faculty of Medicine, University of Tokyo, Japan.
Kawase
T
T
Komatsu
Y
Y
Hikiba
Y
Y
Okano
K
K
Kamii
K
K
Omata
M
M
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002455:Cell Division; D004731:Endotoxins / Q000494:pharmacology*; D007728:Kupffer Cells / Q000502:physiology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000166:cytology* / Q000502:physiology; D008107:Liver Diseases / Q000503:physiopathology*; D008115:Liver Regeneration / Q000502:physiology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains
D004731:Endotoxins; D008070:Lipopolysaccharides