The effects of 4 weeks treatment with cisapride on cystometric parameters in spinal cord injury patients. A double-blind, placebo controlled study.
A group of 21 complete spinal cord injury patients, beyond the phase of spinal shock, were given a treatment of cisapride at random, 10 mg four times a day for 4 weeks. Cystometry was performed first before the start and during the following 4 weeks. No statistically significant difference could be found in the urodynamic parameters between the two groups at the first cystometry. No statistically significant change of the urodynamic parameters could be demonstrated with the treatment, although a non-statistically significant bladder stimulating effect was present in a majority of the patients in the cisapride group.
Wyndaele
J J
JJ
Department of Urology, University Hospital Antwerp, Belgium.
Van Kerrebroeck
P
P
D000293:Adolescent; D000328:Adult; D020117:Cisapride; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000627:therapeutic use*; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications / Q000534:rehabilitation*; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects
D010277:Parasympathomimetics; D010880:Piperidines; D020117:Cisapride