Genetic susceptibility to ozone exposure.
Because of the impact that oxidizing air pollutants such as ozone (O3) may have on public health, identification of factors that influence susceptibility to exposure remains a critical issue. The role of genetic background as a susceptibility factor is becoming increasingly clear. In this paper, evidence is reviewed which suggests that susceptibility to O3 is a heritable trait in humans. Experimental studies are also described that characterize the mode of inheritance of O3-induced lung injury in inbred strains of mice. It is suggested that future investigations should strive to identify phenotypic markers of susceptibility as a means to identify individuals who are genetically at risk for the development of oxidant-induced lung injury.
Kleeberger
S R
SR
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
D000818:Animals; D001249:Asthma / Q000139:chemically induced; D005823:Genetics; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D008168:Lung / Q000187:drug effects; D051379:Mice; D010126:Ozone / Q000633:toxicity*
D010126:Ozone