title: MICs of 28 antibiotic compounds for 14 Bartonella (formerly Rochalimaea) isolates.
abstract: We assessed in vitro the antibiotic susceptibilities of 14 Bartonella isolates of the species B. quintana, B. vinsonii, B. henselae, and B. elizabethae. Columbia agar base supplemented with 5% horse blood was used as the antibiotic assay medium. Bacterial growth could be evaluated within 5 days after incubation of the plates at 37 degrees C in a 5% carbon dioxide atmosphere. The MICs at which 90% of isolates are inhibited (MIC90s) were 0.06 microgram/ml for penicillin G and amoxicillin and 0.25 microgram/ml for ticarcillin and cefotaxime. The MIC90s of oxacillin and cephalothin were 4 and 16 micrograms/ml, respectively. The MIC90s ranged from 1 to 4 micrograms/ml for aminoglycosides. Erythromycin, doxycycline, and rifampin displayed MIC90s of 0.12, 0.12, and 0.25 microgram/ml, respectively. MIC90s were 1 and 5 micrograms/ml for trimethoprim-and sulfamethoxazole, respectively, 64 micrograms/ml for fosfomycin, and 16 micrograms/ml for colistin and vancomycin. The study confirms the high levels of in vitro susceptibility of Bartonella agents to antibiotics.
authors.affiliation: Unité des Rickettsies, Faculté de Médecine, Centre National de la Recherche Scientifique EP J0054, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Maurin
authors.forename: S
authors.initials: S
authors.lastname: Gasquet
authors.forename: C
authors.initials: C
authors.lastname: Ducco
authors.forename: D
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001473:Bartonella / Q000187:drug effects*; D001474:Bartonella Infections / Q000382:microbiology; D003470:Culture Media; D006801:Humans; D008826:Microbial Sensitivity Tests; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media