A comparative study of one-year weight gain among users of medroxyprogesterone acetate, levonorgestrel implants, and oral contraceptives.
With the recent introduction and growing popularity of Depo-Provera Contraceptive Injection, concern about the potential for weight gain during treatment has been raised. The purpose of the present study was to determine whether or not Depo-Provera Contraceptive Injection is associated with greater weight gain, and incidence thereof, than Norplant implants or oral contraceptives. A retrospective chart review of patients seen at a state- and federally-funded clinic was conducted. Fifty women in each treatment group who met the study criteria were identified and included in the study evaluation. Mean one-year weight gain for subjects in each group was as follows: -2.0 pounds in the oral contraceptive group, -1.8 pounds in the Norplant implants group, and +0.1 pounds in the Depo-Provera Contraceptive Injection group. While results among treatment groups differed slightly, no significant weight change occurred in any of the treatment groups.
Moore
L L
LL
Payless Drug, Denver, CO, USA.
Valuck
R
R
McDougall
C
C
Fink
W
W
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005260:Female; D006801:Humans; D007267:Injections; D016912:Levonorgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*; D012189:Retrospective Studies; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology
D003276:Contraceptives, Oral; D003692:Delayed-Action Preparations; D004343:Drug Implants; D045167:Progesterone Congeners; D016912:Levonorgestrel; D017258:Medroxyprogesterone Acetate