title: Interferon alpha therapy for chronic active hepatitis type C after renal transplantation and allograft rejection.
abstract: An acute type rejection episode occurred in one of two patients treated with Interferon alpha (IFN alpha) for type C hepatitis (CHC). Histopathological examination of the graft kidney revealed focal cellular infiltration and chronic transplant glomerulopathy which showed acute or chronic type rejection. In spite of bolus administration of methyl-prednisolone, the elevation of serum creatinine level continued. After administration of anti-human lymphocyte globulin (AHLG), renal function improved, but urinary protein was still positive. Another patient had no episode of rejection during or after IFN alpha therapy.
authors.affiliation: Department of Urology, Osaka University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takahara
authors.forename: K
authors.initials: K
authors.lastname: Kakimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kokado
authors.forename: H
authors.initials: H
authors.lastname: Kameoka
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: S
authors.initials: S
authors.lastname: Kawada
authors.forename: M
authors.initials: M
authors.lastname: Kyo
authors.forename: S
authors.initials: S
authors.lastname: Nagano
authors.forename: O
authors.initials: O
authors.lastname: Mikami
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000328:Adult; D006084:Graft Rejection; D006526:Hepatitis C / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D016896:Treatment Outcome
chemical_list: D016898:Interferon-alpha