title: Preparation and pharmacological evaluation of 1-(1,4-benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes as potent cerebral protective agents.
abstract: Two new series of 1-(1,4-benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes (3,4) were synthesized for evaluation of their pharmacological activities. These compounds showed significant anti-lipid peroxidation (ALP) activities with rat brain homogenate and some of them possessed a protective effect against hypobaric hypoxia in mice.
authors.affiliation: Suntory Institute for Biomedical Research, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tatsuoka
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Aisaka
authors.forename: R
authors.initials: R
authors.lastname: Ogino
authors.forename: M
authors.initials: M
authors.lastname: Kuroki
authors.forename: F
authors.initials: F
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Miyano
authors.forename: K
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy; D002560:Cerebrovascular Circulation / Q000187:drug effects; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D016227:Benzoquinones; D018696:Neuroprotective Agents; D013764:Tetrahydronaphthalenes