title: Effect of intramuscular polysulfated glycosaminoglycans on bovine semen production and quality of the cryopreserved semen.
abstract: Polysulfated glycosaminoglycans (PSGAG) are widely used to treat cartilage disease in horses. The drug's safety in breeding animals has not been documented. This study determined whether im PSGAG is detrimental to the bull's health and, in particular, the quantity of semen produced or the quality of the cryopreserved product. No clinically significant effect of treatment on hematologic or serum biochemistry parameters was detected, but a significant treatment x time interaction for mean corpuscular volume warrants further investigation. There was an unexplained treatment effect on total daily sperm numbers collected, even though the pre-treatment values were included as co-variates in the statistical analysis to control for any day 0 variability. There was no effect on the percent forward motile sperm in the fresh ejaculate. Although there was no significant effect of treatment on the post-thaw semen data, the power of each statistical analysis was low, ranging from 10% to 19%. Further studies using larger sample sizes are warranted. These preliminary studies suggest that im PSGAG is safe to use in bulls on an experimental basis.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Frazer
authors.forename: R F
authors.initials: RF
authors.lastname: Rohde
authors.forename: D R
authors.initials: DR
authors.lastname: Monke
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001774:Blood Chemical Analysis; D002417:Cattle; D015925:Cryopreservation; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D008297:Male; D012098:Reproduction / Q000187:drug effects; D012661:Semen / Q000187:drug effects* / Q000378:metabolism; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects
chemical_list: D006025:Glycosaminoglycans; C013786:A73025