Independent modes of natural killing distinguished in mice lacking Lag3.
The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing.
Miyazaki
T
T
Institut de Génétique et de Biologie Moléculaire et Cellulaire (INSERM, CNRS, ULP), Strasbourg, France.
Dierich
A
A
Benoist
C
C
Mathis
D
D
D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D003602:Cytotoxicity, Immunologic; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009154:Mutation; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology; D014407:Tumor Cells, Cultured; D001613:beta 2-Microglobulin / Q000172:deficiency / Q000502:physiology; D000093322:Lymphocyte Activation Gene 3 Protein
D015703:Antigens, CD; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D001613:beta 2-Microglobulin; D000093322:Lymphocyte Activation Gene 3 Protein; C000720327:Lag3 protein, mouse