title: Microcytic anemia with iron malabsorption: an inherited disorder of iron metabolism.
abstract: Two siblings were identified with severe hypoproliferative microcytic anemia and iron malabsorption, in the absence of any gastrointestinal disorder or blood loss. These children had severe microcytosis (MCV 48 fl, hemoglobin 7.5 g/dl) with decreased serum iron, elevated serum TIBC, and decreased serum ferritin, despite prolonged treatment with oral iron. An iron challenge study with an oral dose of 2 mg/kg elemental iron as ferrous sulfate documented iron malabsorption. After treatment with intravenous iron dextran, there was an absence of the expected reticulocytosis and only a partial correction of the hemoglobin, hematocrit, and microcytosis. The bone marrow was hypocellular with abnormal iron incorporation into erythroid precursor cells. This appears to be a rare form of inherited anemia characterized by iron malabsorption and disordered iron metabolism that only partially corrects after the administration of parenteral iron. These features resemble those found in the microcytic mouse (mk/mk), which also has severe microcytic anemia and iron malabsorption that partially responds to parenteral iron.
authors.affiliation: Deparment of Hematology and Vascular Biology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center Washington, DC 20307-5100, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Hartman
authors.forename: J A
authors.initials: JA
authors.lastname: Barker
mesh_terms: D000284:Administration, Oral; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000209:etiology*; D000818:Animals; D001692:Biological Transport; D001853:Bone Marrow / Q000473:pathology; D002451:Cell Compartmentation; D048429:Cell Size; D002648:Child; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D003398:Craniosynostoses / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D004913:Erythrocytes, Abnormal; D015672:Erythroid Precursor Cells / Q000473:pathology; D004921:Erythropoietin / Q000097:blood; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D007408:Intestinal Absorption; D007424:Intracellular Fluid / Q000378:metabolism; D007501:Iron / Q000097:blood / Q000493:pharmacokinetics*; D007505:Iron-Dextran Complex / Q000008:administration & dosage / Q000627:therapeutic use; D008286:Malabsorption Syndromes / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains
chemical_list: D005296:Ferrous Compounds; D004921:Erythropoietin; C020748:ferrous sulfate; D007505:Iron-Dextran Complex; D007501:Iron