Serum sodium stabilizing effect of enalapril after standard water load in a patient with a history of self-induced water intoxication.
1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. After a water load, the mean serum sodium on enalapril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.
Sebastian
C S
CS
Georgia Regional Hospital at Augusta, GA, USA.
Sinha
D
D
Gulati
N K
NK
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004311:Double-Blind Method; D004656:Enalapril / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012565:Schizophrenic Psychology; D012964:Sodium / Q000097:blood*; D014869:Water Intoxication / Q000097:blood / Q000188:drug therapy* / Q000523:psychology
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D012964:Sodium