title: Serological comparison of type A foot and mouth disease virus isolates from Thailand.
abstract: Antigenic variation of type A foot and mouth disease (FMD) virus in Thailand was examined using a total of 82 field viruses isolated between 1986 and 1989. A two-dimensional serum microneutralisation test was used to compare these isolates to a reference strain, A15 Bangkok 1960 (A BKK/60). Viruses regarded as unrelated to A BKK/60 were compared to another reference strain, A22 Nakhon Pathom 1986 (A NPT/86). This approach divided the viruses into two groups. Most of the viruses shared a close antigenic relationship with A BKK/60. Only twelve viruses were regarded as unrelated to A BKK/60, and these were related to A NPT/86. All but one of these twelve isolates were from two provinces in one administrative region of the country. Future type A vaccines in Thailand will need to confer protection against both groups of viruses.
authors.affiliation: Commonwealth Scientific and Industrial Research Organisation, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors.forename: W J
authors.initials: WJ
authors.lastname: Doughty
authors.affiliation: Commonwealth Scientific and Industrial Research Organisation, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors.forename: R A
authors.initials: RA
authors.lastname: Lunt
authors.affiliation: Department of Livestock Development, Foot and Mouth Disease Centre, Pak Chong, Nakhon Ratchasima, 30130 Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Lingchongsubonkoch
authors.affiliation: Commonwealth Scientific and Industrial Research Organisation, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Gleeson
authors.affiliation: Department of Livestock Development, Foot and Mouth Disease Centre, Pak Chong, Nakhon Ratchasima, 30130 Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Kongthon
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000032:analysis*; D005537:Aphthovirus / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D002020:Buffaloes; D002417:Cattle; D005536:Foot-and-Mouth Disease / Q000821:virology*; D007106:Immune Sera / Q000276:immunology; D009500:Neutralization Tests / Q000662:veterinary; D011817:Rabbits; D012756:Sheep; D013552:Swine; D013785:Thailand
chemical_list: D000956:Antigens, Viral; D007106:Immune Sera