The role of antibiotics in the treatment of periodontitis. (Part I--Systemic delivery.
Controlled release devices containing tetracyclines or metronidazole are now commercially available for use in periodontal pockets. This review, in two parts, evaluates the evidence for and against using antibiotics in the treatment of periodontitis and considers the role for systemic and local delivery. Guidelines for antibiotic usage and recommended regimes are proposed.
Smith
S R
SR
Department of Periodontology, The London Hospital Medical College, London, UK.
Foyle
D M
DM
Needleman
I G
IG
Pandya
N V
NV
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000627:therapeutic use; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D013754:Tetracyclines / Q000008:administration & dosage* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D013754:Tetracyclines; D008795:Metronidazole