title: Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system?
abstract: Multiple immunologic disturbances are commonly observed in individuals with Down's syndrome including abnormal proportions of peripheral blood lymphoid subsets, cellular dysfunction, and autoimmune phenomena. However, a majority of the individuals with this syndrome do not show clear features of immunological disease. Many of these immunological alterations are age-related changes and can be enclosed in the spectrum of multiple signs of early senescence characteristic of Down's syndrome.
authors.affiliation: Sección de Immunología, Hopsital Ntra Sra de Aránzazu, San Sebastián, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Cuadrado
authors.forename: M J
authors.initials: MJ
authors.lastname: Barrena
mesh_terms: D000375:Aging / Q000276:immunology*; D015703:Antigens, CD; D002648:Child; D004314:Down Syndrome / Q000150:complications / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000503:physiopathology*; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets
chemical_list: D015703:Antigens, CD