title: SARs on an 835 kb DNA fragment from the Drosophila genome.
abstract: We have investigated the loop organization of a 835 kilobases DNA fragment from the Drosophila genome. This analysis has focused on the periodicity of the distribution of anchoring sequences (SARs) and its relationship to the distribution of A,T-rich regions, transcription units, repeated elements, putative replication origins and topoisomerase II cleavage sites. Altogether, the data support the idea of an active participation of SARs to the structural organization and functioning of this eukaryotic genome.
authors.affiliation: Laboratoire de Génétique et Physiologie du Développement, Parc Scientifique de Luminy, Marseille, France.
authors.forename: R
authors.initials: R
authors.lastname: Miassod
authors.forename: N
authors.initials: N
authors.lastname: Jullien
mesh_terms: D000818:Animals; D004261:DNA Replication; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004278:DNA, Superhelical / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D016678:Genome; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004278:DNA, Superhelical; D004250:DNA Topoisomerases, Type II