Plasmacytoid CD8 lymphoma: morphologic and immunologic characterization.
This study describes a 79 year-old female suffering from fever and lymphadenopathy. A lymph node biopsy showed diffuse infiltration of medium-sized cells with plasmacytoid features. The immunologic phenotype determined by cytometric analysis and immunochemistry showed suppressor T antigen (CD2, CD3, CD7, CD8) expression. Absence of CD5 expression characterized this abnormal T cell proliferation. Gamma T cell receptor rearrangement without immunoglobulin heavy-chain gene rearrangement confirmed the T lineage of these plasmacytoid cells and their clonality. Immunological studies are necessary for identification of this T lymphoma with B microscopic findings.
Amiot
L
L
Laboratoire d'Hématologie-Immunologie, CHRU, Rennes, France.
Tas
P
P
Caulet-Maugendre
S
S
Goasguen
J
J
Le Prisé
P Y
PY
Fauchet
R
R
Drenou
B
B
D000368:Aged; D001483:Base Sequence; D018414:CD8-Positive T-Lymphocytes; D004273:DNA, Neoplasm / Q000737:chemistry; D005260:Female; D005434:Flow Cytometry; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D004273:DNA, Neoplasm