[Lipid peroxidation and status of the antioxidant system in opiate addiction, chronic alcoholism, or substance abuse caused by inhaling solvent vapors].
Patterns of lipid peroxidation and the state of antioxidant systems were studied in 30 healthy volunteers (control), 18 patients with toxicomania developed as a result of inspiration of organic solvent vapors, 21 patients with chronic alcoholism and in 27 patients with opium narcomania within 4-6 years after withdrawal. The data obtained suggest that activation of lipid peroxidation and decrease in the rate of antioxidant response, which were detected in the patients with narcomania, correlated with severity of the psychopathological failures induced by chronic toxic effect of the narcotics or toxic preparations applied.
Seledtsov
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D000280:Administration, Inhalation; D000293:Adolescent; D000437:Alcoholism / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D009293:Opioid-Related Disorders / Q000378:metabolism*; D009892:Opium; D012997:Solvents / Q000008:administration & dosage; D019966:Substance-Related Disorders / Q000378:metabolism*
D000975:Antioxidants; D012997:Solvents; D009892:Opium