title: Syntheses and effect of bursin and it analogs on the reduced B lymphocytes of uremic patients.
abstract: A selective B-lymphocyte-differentiating tripeptide, bursin, H-Lys-His-Gly-NH2, and its 10 analogs were synthesized by a solid-phase method and were tested for their effect on reduced B lymphocytes of uremic patients. Incubation of peripheral lymphocytes isolated from uremic patients with the synthetic bursin showed an enhancing effect on the reduced B lymphocytes. Of the s synthetic analogs, [Sar3]bursin exhibited the most potent effect.
authors.affiliation: Kidney Research Laboratory, Kojinkai, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Abiko
authors.forename: H
authors.initials: H
authors.lastname: Sekino
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology*; D002060:Bursa of Fabricius / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008231:Lymphopenia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014511:Uremia / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D009842:Oligopeptides; C016281:bursopoietin