title: A maximal central venous oxygen saturation (SvO2max) for the surgical patient.
abstract: Before induction of anaesthesia, 23 patients scheduled for major abdominal surgery had blood samples drawn from a central venous catheter for oxygen saturation (SvO2) after graded infusion of isotonic saline. The infusion of saline was continued until further administration resulted in a stable SvO2 (SvO2max). The SvO2 increased from 69 (53-83) to 72 (66-83) % (median and range; P < 0.0001), when the patients received 10 (0-26) mL.kg-1, average 500 mL, of saline. At the same time central venous haematocrit decreased from 38 (32-47) to 36 (23-47) % which suggests that the intravascular volume was expanded by 420 (180-3070) mL or by 72 (18-174) % of the administered volume. The results demonstrate that volume expansion by saline can establish a maximal venous oxygen saturation in the surgical patient.
authors.affiliation: Department of Anaesthesia, Righospitalet, University of Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Jenstrup
authors.forename: E
authors.initials: E
authors.lastname: Ejlersen
authors.forename: T
authors.initials: T
authors.lastname: Mogensen
authors.forename: N H
authors.initials: NH
authors.lastname: Secher
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000136:Acid-Base Equilibrium; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000468:Alkalies / Q000097:blood; D001810:Blood Volume; D002245:Carbon Dioxide / Q000097:blood; D002405:Catheterization, Central Venous; D017558:Elective Surgical Procedures; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000627:therapeutic use; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000468:Alkalies; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D002245:Carbon Dioxide; D012965:Sodium Chloride; D010100:Oxygen