[Oxidative phosphorylation activity, F0F1-ATPase and level of liver mitochondrial cytochromes in rats with congenitally increased ability for free radical formation].
The rates of oxygen consumption in liver mitochondria of strain S rats (2-3- and 10-12-months-old) with inherited free radical hyperproduction during oxidation of three types of substrates (glutamate+maleate, succinate+rotenone and ascorbate+TMPD) as well as cytochrome a level in the respiratory chain are lowered in comparison with Wistar controls. In liver mitochondria of 10-12-months-old rats these changes are more pronounced and manifest themselves as decreased ADP/O, phosphorylation rates and F0F1-ATPase activity. The phosphorylation potential, ATP content and adenine nucleotide pool in rat liver are also reduced. The experimental results give a better insight into the pathogenetic mechanisms of morbid states (e.g., degenerative diseases) in human beings and shed additional light on the origin of short lifespan and premature in strain S rats.
Shabalina
I G
IG
Kolosova
N G
NG
Grishanova
A Iu
AIu
Solov'ev
V N
VN
Salganik
R I
RI
Solov'eva
N A
NA
D000818:Animals; D003580:Cytochromes / Q000378:metabolism*; D004579:Electron Transport; D005609:Free Radicals; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology* / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D003580:Cytochromes; D005609:Free Radicals; D006180:Proton-Translocating ATPases; D010100:Oxygen