Activities of vagal receptors in the different phases of sneeze in cats.
We studied the activity of 50 slow-adapting receptors (SAR), 13 rapidly-adapting receptors (RAR) and 3 expiratory modulated receptors in the different phases of sneeze in tracheostomized and non-tracheostomized anaesthetized cats. SAR activity increased progressively during the first phase of the preparatory inspiration in parallel to integrated diaphragmatic activity. During the second phase of the preparatory inspiration, SAR increased their discharge frequency; higher threshold SAR and RAR were recruited. During the compressive phase, discharge of SAR kept stable or increased slightly in parallel to an increase in transpulmonary pressure, while expiratory modulated receptors were activated. During the expulsive phase, only RAR were activated. Increase in transpulmonary pressure at the end of the inspiration phase of sneeze shortened expiratory duration and increased the rate of rise of expiratory muscle activity. Increase in transpulmonary pressure at the end of the compressive phase further shortened expiratory duration. These results suggest: first, a facilitatory effect on the triggering of the second phase of the preparatory inspiration from SAR; second, a modulation of the early stage of expiration by SAR, RAR and expiratory modulated receptors during the compressive phase; third, a permissive effect on a rapid expulsive thrust by SAR which can be further limited by RAR; fourth, a facilitatory effect on the triggering of inspiratory activity that follows the expiratory thrust by RAR. Both SAR and RAR might participate in the occurrence of successive sneeze in an attack and in the increased frequency of sneezing. Our results suggest that complex convergent inputs from nasal and vagal receptors, which alter the respiratory rhythm and rhythmogenesis, modulate finely the sneeze reflex.
Wallois
F
F
Laboratoire de Neurophysiologie, CNRS URA 1331, Faculté de Médecine, Université de Picardie, Amiens, France.
Macron
J M
JM
Duron
B
B
D000818:Animals; D002415:Cats; D004947:Esophagus / Q000502:physiology; D008176:Lung Volume Measurements; D012119:Respiration / Q000502:physiology; D011984:Sensory Receptor Cells / Q000737:chemistry / Q000473:pathology*; D012912:Sneezing / Q000502:physiology*; D014132:Trachea / Q000502:physiology; D014139:Tracheostomy; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology