Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam.
Convulsive activity of N-(3,5-dimethoxy-4-propoxy-phenyl-ethyl)-aziridine (FAZ-4), a newly synthetized aziridine compound was studied in rats. There is a lack of tonic component of major paroxysm in comparison with the classical convulsive agent pentylenetetrazol. This effect of FAZ-4 is probably due to the forebrain mechanism without the midbrain involvement. Both anticonvulsants tested suppressed seizures in a different manner, however triazolam exerted stronger anticonvulsive activity than the same dose of diazepam did.
Herink
J
J
Military Medical Academy, Hradec Králové.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001388:Aziridines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D014229:Triazolam / Q000494:pharmacology*
D000927:Anticonvulsants; D001388:Aziridines; C098190:N-((3,5-dimethoxy-4-propoxyphenyl)ethyl)aziridine; D014229:Triazolam; D003975:Diazepam