Toxicity of iron and hydrogen peroxide: the Fenton reaction.
Iron and hydrogen peroxide are capable of oxidizing a wide range of substrates and causing biological damage. The reaction, referred to as the Fenton reaction, is complex and capable of generating both hydroxyl radicals and higher oxidation states of the iron. The mechanism and how it is affected by different chelators, and the interpretation of results obtained in biological systems, are discussed.
Winterbourn
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Department of Pathology, Christchurch School of Medicine, New Zealand. CCW@CHMEDS.AC.NZ
D000818:Animals; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D017665:Hydroxyl Radical; D007501:Iron / Q000378:metabolism / Q000633:toxicity*; D010084:Oxidation-Reduction
D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D007501:Iron