Placental permeability for drugs of abuse and their metabolites.
Placental passage of drugs, including peptides, is determined by the physical and chemical properties of the drug and the physiology of the placenta. Fetal blood concentrations of drugs administered to the mother depend upon time after maternal drug administration, dose, placental blood flow and permeability, plasma protein binding, blood pH, placental biotransformation, and fetal elimination.
Olsen
G D
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Department of Pharmacology-L221, Oregon Health Sciences University, Portland 97201-3098, USA.
D000818:Animals; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000493:pharmacokinetics*; D010455:Peptides / Q000493:pharmacokinetics; D010539:Permeability; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D013287:Illicit Drugs; D010455:Peptides