Clonal evolution of chronic lymphocytic leukemia to acute lymphoblastic leukemia.
A 38-year-old white man was diagnosed with B-cell chronic lymphocytic/prolymphocytic leukemia (CLL/PLL). The disease was unresponsive to a variety of chemotherapeutic regimes. One year after diagnosis, L3 blasts appeared in peripheral blood associated with more aggressive course. There was no change in the B-cell phenotype at that time, but cytogenetic analysis revealed the appearance of t(8;22)(q24;q11) and -21 superimposed on the original karyotype: 46,XY,+3,der(3)t(3;17)(p11;q12), t(11;14)(q13;q32),-17. These results indicate that the lymphoblastic transformation in our case emerged from the pre-existing B-lymphocytic clone.
Mohamed
A N
AN
Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA.
Compean
R
R
Dan
M E
ME
Smith
M R
MR
Al-Katib
A
A
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002999:Clone Cells; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*