7-Nitro-indazole, a selective inhibitor of neuronal nitric oxide synthase, reduces formalin evoked c-Fos expression in dorsal horn neurons of the rat spinal cord.
The effect of intravenous 7-nitro-indazole (7NI), a selective inhibitor of neuronal nitric oxide synthase, on intraplantar formalin evoked spinal expression of c-Fos was studied. The spinal expression of c-Fos in the superficial laminae of the dorsal horn was not significantly altered by 7NI. In contrast formalin evoked c-Fos expression in the deep laminae was reduced by 15 mg/kg of 7NI (42 +/- 8% reduction of control, P < 0.05). Formalin evoked inflammation was not influenced by 7NI. Our results implicate a functional relationship between c-Fos expression and nitric oxide, at the spinal level, under inflammatory conditions.
Chapman
V
V
INSERUM U 161, Paris, France.
Buritova
J
J
Honoré
P
P
Besson
J M
JM
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005557:Formaldehyde / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism
D004791:Enzyme Inhibitors; D007191:Indazoles; D016760:Proto-Oncogene Proteins c-fos; D005557:Formaldehyde; D019001:Nitric Oxide Synthase; C080122:7-nitroindazole