Effect of octreotide infusion on hepatic and tumour blood flow in two experimental models of liver metastases.
OBJECTIVE
To investigate the effects of octreotide infusion on hepatic and tumour blood flow in rats with experimentally induced liver tumours.


METHODS
Blood flow was determined in tumour-bearing rats using a dual reference microsphere technique before and after intravenous infusion of octreotide.


METHODS
Tumours were induced in syngeneic rats by intraportal injection of K12-Tr and WB2054-M adenocarcinoma cells. Hepatic arterial and portal venous inflow, tumour blood flow and systemic arterial pressure were determined before and after octreotide infusion (0.05 microgram/min).


RESULTS
In rats with K12-Tr tumours there was no change in tumour blood flow, hepatic arterial flow or portal venous inflow after octreotide infusion. In contrast, in rats with WB2054-M tumours, octreotide infusion resulted in a significant reduction in the blood flow to the hepatic tumour (from 0.37 to 0.135 ml/min/g) but had no effect on hepatic artery or portal venous inflow.


CONCLUSIONS
The reduction in blood flow to tumours derived from WB2054-M cells could, at least in part, explain the inhibitory effect of octreotide on the growth and development of these tumours. However, octreotide had no effect on blood flow to tumours derived from K12-Tr cells, suggesting that the analogue must inhibit tumour growth by other mechanisms.
Davies
N
N
Department of Surgery, University of Liverpool, UK.
Kynaston
H
H
Yates
J
J
Nott
D M
DM
Taylor
B A
BA
Jenkins
S A
SA
D000230:Adenocarcinoma / Q000098:blood supply / Q000556:secondary*; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003110:Colonic Neoplasms / Q000098:blood supply*; D007262:Infusions, Intravenous; D008099:Liver / Q000098:blood supply*; D008113:Liver Neoplasms / Q000098:blood supply / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D015282:Octreotide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide