Effect of hyperthyroidism on the biliary release of thiobarbituric acid reactants in the rat.
The influence of daily doses of 0.1 mg 3,3',5-triiodothyronine (T3)/kg for three consecutive days on hepatic lipid peroxidation was assessed by the biliary release of thiobarbituric acid reactants (TBARS) in anesthetized rats. T3 treatment elicited a significant 80% increase in the biliary efflux of TBARS compared to control values, an effect determined by increments in both the TBARS concentration in bile (44%) and in the bile flow (25%). It is concluded that hyperthyroidism-induced oxidative stress stimulates hepatic lipid peroxidation measured in an in situ liver preparation, which significantly correlates with the enhancement in the rate of TBARS production assessed in liver homogenates.
Fernández
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Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Videla
L A
LA
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006980:Hyperthyroidism / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014284:Triiodothyronine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D017392:Thiobarbituric Acid Reactive Substances; D014284:Triiodothyronine