title: The effect of left ventricular dP/dt on the in vitro dynamics of the Björk-Shiley Convexo-Concave mitral valve.
abstract: Left ventricular (LV) dP/dt is considered an important hemodynamic factor influencing the dynamics of mechanical heart valve prostheses. LV dP/dt is dependent on patient factors including age, cardiac activity, health, and medication. The objective of this study was to determine the effect of LV dP/dt on the closing dynamics of mechanical heart valve prostheses in the mitral position. Eight instrumented 29 mm Björk-Shiley Convexo-Concave (BSCC) heart valves were tested in the pulse duplicator of the Helmholtz Institute. The valves had miniature strain gages mounted at the base of the outlet strut to measure impact loads at closure. Closing velocities were measured with a "light gate" device which was triggered by the closing leaflet. Physiologic pressure and flow waveforms were generated by a computer-controlled hydraulic drive unit. LV dP/dt was varied from 500 to 4000 mmHg/s simulating a wide range of physiologic conditions. It was found that the closing velocity was almost linearly related to LV dP/dt. At 4000 mmHg/s, closing velocities ranged from 1.5 to 2.0 m/s. Impact loads increased monotonically with LV dP/dt and closing velocity. In some valves, impact loads reached 2800 g at LV dP/dt of 4000 mmHg/s, and closing velocities of 2.0 m/s.
authors.affiliation: Helmholtz-Institute, Aachen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Rau
authors.forename: H
authors.initials: H
authors.lastname: Reul
authors.forename: M
authors.initials: M
authors.lastname: Eichler
authors.forename: S
authors.initials: S
authors.lastname: Schreck
authors.forename: D W
authors.initials: DW
authors.lastname: Wieting
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002302:Cardiac Output; D003201:Computers; D006339:Heart Rate; D006350:Heart Valve Prosthesis; D006801:Humans; D008027:Light; D008422:Materials Testing; D008904:Miniaturization; D008943:Mitral Valve; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009991:Oscillometry; D011474:Prosthesis Design; D011673:Pulsatile Flow; D012756:Sheep; D013318:Stroke Volume; D014159:Transducers; D014655:Vascular Resistance; D016277:Ventricular Function, Left; D017725:Ventricular Pressure