title: Intractable seizures associated with brain tumor in childhood: lesionectomy and seizure outcome.
abstract: The authors retrospectively reviewed ten pediatric brain tumor patients with intractable seizures who underwent lesionectomy without intentional identification and resection of the epileptogenic region to assess the clinical features and seizure outcome after lesionectomy in such patients. Seizures were complex partial in seven cases and simple partial, absence, and generalized tonic-clonic in one case each. Tumors were located at the medial temporal lobe in four cases, at the frontal lobe in four cases, at the parietooccipital and the suprasellar areas in one case each. The most common pathology was benign oligodendroglioma (five cases) followed by ganglioglioma (two cases). Others were pleomorphic xanthoastrocytoma, hamartoma, and primitive neuroectodermal tumor (one case each). In four cases, complete removal of the tumor was feasible. Postoperatively nine of the ten patients showed favorable seizure control (Engel's classification 1 and 2) and of these, six were seizure-free during the follow-up period (mean duration: 40 months). Therefore, lesionectomy can be an appropriate initial treatment for patients with brain tumor and medically intractable seizures.
authors.affiliation: Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Wang
authors.forename: B K
authors.initials: BK
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000209:etiology* / Q000601:surgery*; D013702:Temporal Lobe / Q000473:pathology*; D016896:Treatment Outcome