title: [Pulmonary function and the pathogenesis of obstructive sleep apnea syndrome].
abstract: We studied the relationships between results of pulmonary-function tests and sleep-induced respiratory disorders in men with obstructive sleep apnea syndrome (OSAS). Pulmonary-function tests were done in 23 men with OSAS and in 9 men without OSAS who were matched for age and body mass index. Tests were done both in sitting and in supine positions. For both positions, results of pulmonary-function tests did not differ between the OSAS and the non-OSAS groups. In both groups, %TLC, %FRC, PaO2, and V25/Ht were lower while supine than while sitting, and CC/FRC was higher. In both positions, CC/FRC was significantly and positively correlated with apnea index and with 4% desaturation time. Body mass index was not correlated with apnea index or with 4% desaturation time. These findings suggest that low lung volume and peripheral airway closure contribute to sleep-induced respiratory disorders in men with OSAS, regardless of the body mass index.
authors.affiliation: First Department of Internal Medicine, Asahikawa Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akiba
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: S
authors.initials: S
authors.lastname: Osanai
authors.forename: T
authors.initials: T
authors.lastname: Ogasa
authors.forename: S
authors.initials: S
authors.lastname: Fujiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nishigaki
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology