title: Developmental changes of nitric oxide synthase in the rat superior colliculus.
abstract: We used the activity of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) to detect the presence of nitric oxide synthase (NOS) in the developing rat superior colliculus. Our results showed that NOS is present in cells and neuropil in the developing and adult rat superior colliculus. The first NOS-positive cells were detected at postnatal day 7 and were weakly stained. During the following days the number of stained cells increased markedly, reaching a peak by postnatal day 15, coinciding with the time of eye opening in the rat. By the end of the third postnatal week, both the number and intensity of stained cells showed an adult-like pattern. We conclude that NOS expression lags behind the initial period of reorganization of the retinotectal projection. However, NOS activity could be involved in the subsequent synaptic remodeling and plasticity of the retinocollicular projection.
authors.affiliation: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Tenório
authors.forename: A
authors.initials: A
authors.lastname: Giraldi-Guimarães
authors.forename: R
authors.initials: R
authors.lastname: Mendez-Otero
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006651:Histocytochemistry; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D051381:Rats; D012160:Retina / Q000166:cytology / Q000201:enzymology / Q000254:growth & development; D013477:Superior Colliculi / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development*; D014795:Visual Pathways / Q000166:cytology / Q000201:enzymology / Q000254:growth & development
chemical_list: D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase