Successful treatment of cryptococcal meningitis with amphotericin B colloidal dispersion: report of four cases.
Four patients with cryptococcal meningitis were treated with amphotericin B colloidal dispersion because of nephrotoxicity from prior treatment with conventional amphotericin B. The limited experience presented here suggests that amphotericin B colloidal dispersion is efficacious for the treatment of cryptococcal meningitis, despite being undetectable in cerebrospinal fluid, and offers a potential therapeutic alternative for patients who cannot tolerate conventional amphotericin B.
Valero
G
G
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7870, USA.
Graybill
J R
JR
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003102:Colloids; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D016027:Heart Transplantation; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications; D013535:Suspensions
D000935:Antifungal Agents; D003102:Colloids; D013535:Suspensions; D000666:Amphotericin B