Growth hormone deficiency in adults: a review.
For more than 35 years, growth hormone (GH) has been used to promote linear growth in GH-deficient children. Previously, GH replacement in adults was limited to the supply of human pituitary-derived GH. In addition, until recently, GH replacement was not deemed clinically indicated. With the introduction of recombinant human prion-free GH, replacement therapy in GH-deficient adults has become feasible, and its use has burgeoned. In this review, recent studies on GH therapy in healthy and GH-deficient adults are evaluated to provide a rational basis for the widened scope of its clinical application.
Meling
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Department of Medicine, Veterans Affairs Medical Center, Washington, DC, USA.
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D000328:Adult; D001823:Body Composition / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects; D017079:Exercise Tolerance / Q000187:drug effects; D013006:Growth Hormone / Q000009:adverse effects / Q000172:deficiency* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000097:blood; D018482:Muscle, Skeletal / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use
D008055:Lipids; D011506:Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone