Polymorphisms within the atrial natriuretic peptide gene in essential hypertension.
OBJECTIVE
To investigate polymorphisms in the atrial natriuretic peptide gene of African Americans at intron two (Hpall) and exon three (Scal).


RESULTS
The allele frequency of the Hpall mutation was 25% in the hypertensive group (n =60) compared with only 3.4% in normotensive individuals (n = 44, P < 0.0001). The genotype heterozygote for the present mutation was much more common among those with hypertension (50 versus 6.8%, P < 0.0001). The groups were no different for the Scal site alone, although the two mutations were present together more often in the hypertensive group. The Hpall mutation was associated with hypertension in this typically salt-sensitive population.
Rutledge
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DR
College of Pharmacy, Department of Pharmacy Practice, University of Florida, Gainesville 32610, USA.
Sun
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Y
Ross
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EA
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005091:Exons; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D007438:Introns; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D001741:Black or African American
D009320:Atrial Natriuretic Factor