Delayed elevation of platelet activating factor in ischemic hippocampus.
We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.
Pettigrew
L C
LC
Stroke Program of the Sanders-Brown Center of Excellence in Aging, University of Kentucky College of Medicine, Lexington 40536-0230, USA.
Meyer
J J
JJ
Craddock
S D
SD
Butler
S M
SM
Tai
H H
HH
Yokel
R A
RA
D000704:Analysis of Variance; D000818:Animals; D006624:Hippocampus / Q000098:blood supply* / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D010865:Pilot Projects; D010972:Platelet Activating Factor / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D015424:Reperfusion; D013929:Thromboxane B2 / Q000378:metabolism
D010972:Platelet Activating Factor; D013929:Thromboxane B2