title: Efficacy of SAD (Berne) rabies vaccine given by the oral route in two species of jackal (Canis mesomelas and Canis adustus).
abstract: Eight black-backed jackals (Canis mesomelas) and seven side-striped jackals (Canis adustus) were given SAD (Berne) rabies vaccine by direct oral instillation. Three different vaccine doses were used: 10(6.3), 10(6.8) and 10(7.5) median tissue culture infectious doses. Two additional jackals were given vaccine in chicken heads. One group of jackals was challenged with a lethal dose of jackal-derived rabies virus 1 mo after vaccination and a second group 12 mo after vaccination. All 17 vaccinated jackals developed high and persistent serum neutralizing antibody titers. All challenged jackals resisted a lethal dose of rabies virus, whereas three control jackals given the same challenge succumbed to rabies.
authors.affiliation: Veterinary Research Laboratory, Causeway, Harare, Zimbabwe.
authors.forename: J
authors.initials: J
authors.lastname: Bingham
authors.forename: A
authors.initials: A
authors.lastname: Kappeler
authors.forename: F W
authors.initials: FW
authors.lastname: Hill
authors.forename: A A
authors.initials: AA
authors.lastname: King
authors.forename: B D
authors.initials: BD
authors.lastname: Perry
authors.forename: C M
authors.initials: CM
authors.lastname: Foggin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002335:Carnivora; D002460:Cell Line; D006224:Cricetinae; D009500:Neutralization Tests / Q000662:veterinary; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage; D011820:Rabies virus / Q000276:immunology; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D015030:Zimbabwe
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines