title: Fluoxetine and cyclosporine in organ transplantation. Failure to detect significant drug interactions or adverse clinical events in depressed organ recipients.
abstract: Depression and anxiety disorders are common clinical problems in organ transplant recipients, but there is a paucity of clinical data to inform the selection of psychopharmacologic treatment. The authors retrospectively compared 13 depressed organ transplant recipients treated with fluoxetine with 13 nondepressed matched control recipients and 11 transplant recipients treated with tricyclic antidepressants (nortriptyline or desipramine). Blood level:dose ratios and dose-response relationships for cyclosporine were virtually identical in all three groups before and during treatment. No increase in adverse clinical events was detected in either active treatment group compared with the control subjects. Fluoxetine appeared to be well tolerated by this population of transplant patients, and the authors failed to detect significant alterations in cyclosporine levels or graft function.
authors.affiliation: University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences 90024, USA.
authors.forename: T B
authors.initials: TB
authors.lastname: Strouse
authors.forename: L A
authors.initials: LA
authors.lastname: Fairbanks
authors.forename: C E
authors.initials: CE
authors.lastname: Skotzko
authors.forename: F I
authors.initials: FI
authors.lastname: Fawzy
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology* / Q000627:therapeutic use*; D016572:Cyclosporine / Q000097:blood* / Q000378:metabolism* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology*; D003891:Desipramine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D006084:Graft Rejection / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000378:metabolism* / Q000627:therapeutic use; D009661:Nortriptyline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016377:Organ Transplantation / Q000523:psychology*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007166:Immunosuppressive Agents; D005473:Fluoxetine; D016572:Cyclosporine; D009661:Nortriptyline; D003891:Desipramine