title: Imaging allergen-invoked airway inflammation in atopic asthma with [18F]-fluorodeoxyglucose and positron emission tomography.
abstract: BACKGROUND
  Airway inflammation is a feature of asthma and can be quantified invasively with bronchial lavage and endobronchial histology. Inflammatory foci can be imaged non-invasively with positron emission tomography (PET) and [18F]-fluorodeoxyglucose (18FDG) to quantify glucose uptake in activated granulocytes. We used this technique to study airway inflammation in asthma.
  
  
  METHODS
  Nine men with mild atopic asthma were studied. In five, we studied the effect of bronchoscopic segmental allergen challenge on 18FDG uptake. Allergen was instilled into the posterior segment of the right upper lobe; a similar volume (20 mL) of isotonic saline was instilled into the posterior segment of the left upper lobe. At 1-32 h after instillation, PET with 18FDG was done. In the other four patients, we administered aerosolised allergen.
  
  
  RESULTS
  18FDG uptake was increased four-fold in the right compared with the left upper lobe (geometric mean of ratios 4.30, 95% Cl 2.39-7.72, p=0.002). Aerosolised administration of allergen did not significantly increase 18FDG uptake.
  
  
  CONCLUSIONS
  These data show that local allergen-invoked airway inflammation can be visualised with 18FDG and PET in asthma. The cellular localisation of the 18FDG signal remains to be determined.
authors.affiliation: Department of Respiratory Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
authors.forename: I K
authors.initials: IK
authors.lastname: Taylor
authors.forename: A A
authors.initials: AA
authors.lastname: Hill
authors.forename: M
authors.initials: M
authors.lastname: Hayes
authors.forename: C G
authors.initials: CG
authors.lastname: Rhodes
authors.forename: K M
authors.initials: KM
authors.lastname: O'Shaughnessy
authors.forename: B J
authors.initials: BJ
authors.lastname: O'Connor
authors.forename: H A
authors.initials: HA
authors.lastname: Jones
authors.forename: J M
authors.initials: JM
authors.lastname: Hughes
authors.forename: T
authors.initials: T
authors.lastname: Jones
authors.forename: N B
authors.initials: NB
authors.lastname: Pride
authors.forename: R W
authors.initials: RW
authors.lastname: Fuller
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000000981:diagnostic imaging* / Q000276:immunology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000000981:diagnostic imaging / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D014055:Tomography, Emission-Computed
chemical_list: D000485:Allergens; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose