The velocity distribution in the aortic annulus at different times during systole is mainly determined by the pattern of flow convergence in the left ventricular outflow tract--an experimental study using Doppler colour flow mapping.
An experimental study in 10 open chest normal pigs (body weight: 24 +/- 1 kg) was carried out to explore the relationship between the velocity distribution in the aortic annulus and the pattern of flow convergence in the left ventricular outflow tract. The cross-sectional velocity profiles in the aortic annulus were constructed by using Doppler colour flow mapping with a previously validated time-interpolation method. The pattern of flow convergence in the left ventricular outflow tract was quantified by measuring the colour flow areas on the anterior and posterior sides of the central axis of the aortic annulus, and calculating their difference. The dynamic changes of the velocity distribution, the pattern of flow convergence and the septal angle throughout systole were observed. The velocity distribution in the aortic annulus changed according to the pattern of flow convergence in the left ventricular outflow tract. During early systole, the pattern of flow convergence was most asymmetrical. With the central longitudinal axis of the aortic annulus as a reference, the main part of the converging flow was along the anterior wall of the left ventricular outflow tract. Consequently, the velocity profile in the aortic annulus was most skewed during the early systole, with the highest velocity along the anterior wall. Towards late systole, the pattern of flow convergence became more and more symmetrical, and the velocity distribution in the aortic annulus gradually became flat. A significant correlation was found between the extent of asymmetry of the pattern of flow convergence in the left ventricular outflow tract and the extent of skewness of the velocity distribution in the aortic annulus (r = 0.69, P < 0.001). Throughout systole, septal angle increased very slightly (from 35 +/- 3 to 38 +/- 3 degrees, P < 0.01). The pattern of flow convergence in the left ventricular outflow tract is a major determinant of the velocity distribution in the aortic annulus in pigs.
Zhou
Y Q
YQ
Medical Department A, University of Bergen, Haukeland Hospital, Norway.
Faerestrand
S
S
Birkeland
S
S
Matre
K
K
Koller
M E
ME
Husby
P
P
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D004562:Electrocardiography; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D013552:Swine; D013599:Systole / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*