title: The role of hyaluronidase on lidocaine and bupivacaine pharmacokinetics after peribulbar blockade.
abstract: Orbital regional anesthesia is the only circumstance where hyaluronidase is routinely added to local anesthetics to accelerate the onset of the block. The aim of this study was to compare the pharmacokinetics of lidocaine and bupivacaine with or without hyaluronidase for peribulbar blockade. Twenty-one patients scheduled for cataract surgery with lens implantation were included in this prospective randomized study. Peribulbar blocks were achieved with plain bupivacaine 0.5% (5.5 mL), lidocaine 2% (5.5 mL), and hyaluronidase (100 IU = 2 mL) (n = 10) ir sterile water (2 mL) (n = 11). Plasma bupivacaine and lidocaine concentrations were measured by high-performance liquid chromatography at regular intervals from the end of the local anesthetic injection until the 360th minute. Maximum plasma concentration (Cmax) and time to reach Cmax (Tmax) were obtained for all the patients except one who needed a supplementary injection and was excluded from the study. The time to onset and duration of the analgesia and akinesia were monitored at the times of sampling. Motor blockade was incomplete in two patients in each group without affecting surgery. The Tmax and absorption half-life (t1/2a) of lidocaine and bupivacaine were not different within each group (P > 0.05). The Tmax of lidocaine was shorter in the presence of hyaluronidase (17.1 +/- 2.6 min vs 32.7 +/- 6.0 min) as well as the Tmax of bupivacaine (16.8 +/- 3.0 min vs 26.5 +/- 4.4 min). The Cmax of lidocaine and bupivacaine were not modified by the addition of hyaluronidase. The clearance, terminal half-life, and volume of distribution were not different between groups. The absorption of lidocaine and bupivacaine from the peribulbar space are hastened by the addition of hyaluronidase. The Tmax of lidocaine is not different from that of bupivacaine within each group suggesting that the absorption of local anesthetics is minimally influenced by the liposolubility of the drugs. Moreover, hyaluronidase influences the absorption kinetics of both lidocaine and bupivacaine in the same manner.
authors.affiliation: Department of Anesthesiology, C.H.R.U. Dupuytren, Limoges, France.
authors.forename: N
authors.initials: N
authors.lastname: Nathan
authors.forename: M
authors.initials: M
authors.lastname: Benrhaiem
authors.forename: H
authors.initials: H
authors.lastname: Lotfi
authors.forename: J
authors.initials: J
authors.lastname: Debord
authors.forename: G
authors.initials: G
authors.lastname: Rigaud
authors.forename: G
authors.initials: G
authors.lastname: Lachatre
authors.forename: J P
authors.initials: JP
authors.lastname: Adenis
authors.forename: P
authors.initials: P
authors.lastname: Feiss
mesh_terms: D000042:Absorption; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D007910:Lenses, Intraocular; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008055:Lipids / Q000737:chemistry; D008297:Male; D008657:Metabolic Clearance Rate; D009046:Motor Neurons / Q000187:drug effects; D009407:Nerve Block; D009915:Orbit / Q000294:innervation*; D011446:Prospective Studies; D012995:Solubility; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D008055:Lipids; D008012:Lidocaine; D006821:Hyaluronoglucosaminidase; D002045:Bupivacaine