title: Aortic atherosclerotic plaques as a source of systemic embolism.
abstract: OBJECTIVE
  Our study was designed to determined the significance of aortogenic embolism in an unselected autopsy collective.
  
  
  BACKGROUND
  Although embolism arising from atherosclerotic plaques in the aorta has been acknowledged, the role of aortic atheromatosis among other well known sources of embolism remains to be further clarified.
  
  
  METHODS
  We examined the proximal part of the arterial system with regard to the presence of atherosclerotic lesions as well as cardiac changes in 120 consecutive necropsy studies. Pathologic evidence of embolic events was recorded. Clinical and neuropathologic data were also surveyed in all patients.
  
  
  RESULTS
  Among atherosclerotic lesions, fibrous plaques (p < 0.05) and calcified (p < 0.0001) and ulcerated lesions (p < 0.0001) as well as thrombi (p < 0.005) were observed significantly more frequently in the aortic arch and in the descending aorta than in the ascending aorta, whereas fatty streaks were distributed uniformly. In 40 (33%) of the 120 patients, we found pathologic evidence of arterial embolization. Multiple logistic regression analysis revealed a significant correlation between embolism and complicated atherosclerotic plaques in the aortic arch (odds ratio [OR] 5.8, 95% confidence interval [CI] 1.1 to 31.7, p < 0.05), severe ipsilateral carotid artery disease (OR 3.1, 95% CI 3.1 to 45.3, p < 0.001) and atrial fibrillation (OR 3.5, 95% CI 1.1 to 9.9, p < 0.05).
  
  
  CONCLUSIONS
  Complicated atherosclerotic plaques in the aortic arch represent an independent risk factor for systemic embolism similar to atrial fibrillation and severe atherosclerosis of the carotid arteries.
authors.affiliation: Department of Cardiology, Medical University of Lübeck, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Khatibzadeh
authors.forename: R
authors.initials: R
authors.lastname: Mitusch
authors.forename: U
authors.initials: U
authors.lastname: Stierle
authors.forename: B
authors.initials: B
authors.lastname: Gromoll
authors.forename: A
authors.initials: A
authors.lastname: Sheikhzadeh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic; D001018:Aortic Diseases / Q000150:complications* / Q000473:pathology; D001161:Arteriosclerosis / Q000150:complications* / Q000473:pathology; D001344:Autopsy; D017700:Embolism, Cholesterol / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors