title: Expression of melanocortin 1 receptor in periaqueductal gray matter.
abstract: The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative. In human PAG, the immunoreactivity for MC1 receptor was detected in scattered cells. These results indicate that a restricted distribution of MC1 receptor is present in the central nervous system.
authors.affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Sweden.
authors.forename: Y
authors.initials: Y
authors.lastname: Xia
authors.forename: J E
authors.initials: JE
authors.lastname: Wikberg
authors.forename: V
authors.initials: V
authors.lastname: Chhajlani
mesh_terms: D000818:Animals; D001483:Base Sequence; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D010487:Periaqueductal Gray / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018043:Receptors, Corticotropin / Q000032:analysis*; D044101:Receptors, Melanocortin
chemical_list: D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin