title: Occurrence of a T cell lymphoma in a patient with chronic myeloid leukemia treated with alpha interferon.
abstract: A patient treated by recombinant human alpha interferon for chronic myeloid leukemia developed a T cell lymphoma. The T cell lymphoma cells were demonstrated to be genotypically different from the chronic myeloid leukemia cells. The possible role of interferon therapy in stimulating T cell proliferation is discussed.
authors.affiliation: Service d'Hématologie, CHU Hôtel-Dieu, Nantes, France.
authors.forename: B
authors.initials: B
authors.lastname: Mahé
authors.forename: F
authors.initials: F
authors.lastname: Gaillard
authors.forename: F
authors.initials: F
authors.lastname: Labadie
authors.forename: S
authors.initials: S
authors.lastname: Papin
authors.forename: S
authors.initials: S
authors.lastname: Letortorec
authors.forename: P
authors.initials: P
authors.lastname: Moreau
authors.forename: J L
authors.initials: JL
authors.lastname: Harousseau
authors.forename: N
authors.initials: N
authors.lastname: Milpied
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced / Q000188:drug therapy; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007155:Immunologic Factors / Q000009:adverse effects*; D016130:Immunophenotyping; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000628:therapy*; D016411:Lymphoma, T-Cell, Peripheral / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D011239:Prednisolone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D000903:Antibiotics, Antineoplastic; D007155:Immunologic Factors; D016898:Interferon-alpha; D011239:Prednisolone; D006918:Hydroxyurea