title: Chronic Q fever of pregnancy presenting as Coxiella burnetii placentitis: successful outcome following therapy with erythromycin and rifampin.
abstract: Chronic Q fever has been associated with endocarditis, granulomatous hepatitis, and osteomyelitis but only rarely with pregnancy. The apparent predilection of Coxiella burnetii, the organism causing Q fever, for the human placenta suggests that chronic Q fever of pregnancy is due to placentitis. We describe a patient with chronic, clinically apparent Q fever in pregnancy and a successful outcome. The diagnosis was made both by serology and by isolation of C. burnetii from the patient's serum and placenta. Therapy with erythromycin and rifampin contributed to the delivery of a healthy baby. The mother's infection was clinically cured by subsequent therapy with doxycycline and rifampin.
authors.affiliation: Department of Medicine, Meir General Hospital, Kfar Saba, Israel.
authors.forename: T
authors.initials: T
authors.lastname: Bental
authors.forename: M
authors.initials: M
authors.lastname: Fejgin
authors.forename: A
authors.initials: A
authors.lastname: Keysary
authors.forename: S
authors.initials: S
authors.lastname: Rzotkiewicz
authors.forename: C
authors.initials: C
authors.lastname: Oron
authors.forename: R
authors.initials: R
authors.lastname: Nachum
authors.forename: Y
authors.initials: Y
authors.lastname: Beyth
authors.forename: R
authors.initials: R
authors.lastname: Lang
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002908:Chronic Disease; D016997:Coxiella burnetii / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000382:microbiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy; D011256:Pregnancy Outcome; D011778:Q Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D004917:Erythromycin; D012293:Rifampin