[Clinical and pathological analysis of fibrillary glomerulopathy].
Four cases of fibrillary glomerulopathy (FGP) were reported for the first time in China. All patients had proteinuria, microscopic hematuria and hypertension. Renal function deteriorated in 2 cases. Pathological findings in light microscopy were sever: MPGN (2 cases), MN (1 case) and MsPGN (1 case). Congo-red stain of renal specimens was negative in all of them. Immunofluoscence (IF) in most of the cases (3/4 cases) showed granular IgG and C3 deposits in mesangium and glomerular basement membrane (GBM). Electron microscopy (EM) showed rich of fibrils distributed randomly over mesangium and GBM, the diameter of fibrils was 20.50 +/- 0.37nm. The diagnosis of FGP depends on EM examination. The actual incidence of FGP in China needs further studies.
Zhang
Y
Y
Institute of Nephrology, First Teaching Hospital, Beijing Medical University.
Wang
S
S
Zou
W
W
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000473:pathology*; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged