Induction of protective CTL responses in newborn mice by a murine retrovirus.
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.
Sarzotti
M
M
Rsearch Service, Veterans Affairs Medical Center, Baltimore, MD 21201, USA.
Robbins
D S
DS
Hoffman
P M
PM
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D016219:Immunotherapy, Adoptive; D007371:Interferon-gamma / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D009052:Leukemia Virus, Murine / Q000276:immunology*; D051379:Mice; D012192:Retroviridae Infections / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*
D015847:Interleukin-4; D007371:Interferon-gamma