[Synthesis of new platelet aggregation inhibitors substituted with pyridylisoxazoles and their 4,5-dihydroanalogs].
A number of substituted pyridylisoxazoles and their 4,5-dihydro analogs were synthesized by 1,3-dipolar cycloaddition of substituted nitrile oxides to either alkenes or alkynes. The synthesized compounds inhibit arachidonic acid-induced aggregation of human thrombocytes at concentrations of 10(-6) to 10(-3) M. Due to low toxicity, these compounds can be regarded as potential antithrombosis medicines.
Demina
O V
OV
Vrzheshch
P V
PV
Khodonov
A A
AA
Kozlovskiĭ
V I
VI
Varfolomeev
S D
SD
D016718:Arachidonic Acid / Q000502:physiology; D006801:Humans; D010080:Oxazoles / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry
D010080:Oxazoles; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid