[Role of trace elements in disorders and correction of metal ligand homeostasis].
Histological, biochemical, and biophysical techniques were used to examine the properties of a biocomplex compound prepared by using the well-known drug metronidazole, which affects gram-negative microbes, with the trace element zinc. The biocomplex was demonstrated to considerably enhance the efficiency of the parent ligand and to expand its action range. The new compound affected the body's immunity, promotes the recovery of its trace element balance and the development of compensatory and adaptative responses in the liver, kidney, spleen, and pancreas. The biocomplex-induced activation of regenerative processes occurred by changing the balance of 28 trace elements in the body. Changes in the skin and blood were analyzed after administration of zinc sulfate in combination with vitamin A (retinol palmitate). An assessment was made of morphological and histochemical changes in the malpighian epithelial cells while using these drugs alone and in combination.
Afanas'ev
Iu I
IuI
Kaletina
N I
NI
Kharitonov
Iu Ia
IuIa
Lazurina
L P
LP
Kakushkina
M L
ML
Zakharova
V F
VF
Garstukova
L G
LG
D000818:Animals; D000994:Antitrichomonal Agents / Q000008:administration & dosage / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008670:Metals / Q000008:administration & dosage / Q000378:metabolism*; D008795:Metronidazole / Q000008:administration & dosage / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013431:Sulfates / Q000008:administration & dosage / Q000378:metabolism; D014131:Trace Elements / Q000378:metabolism / Q000502:physiology*; D014801:Vitamin A / Q000008:administration & dosage; D017967:Zinc Compounds / Q000008:administration & dosage / Q000378:metabolism; D019287:Zinc Sulfate
D000994:Antitrichomonal Agents; D008024:Ligands; D008670:Metals; D013431:Sulfates; D014131:Trace Elements; D017967:Zinc Compounds; D014801:Vitamin A; D008795:Metronidazole; D019287:Zinc Sulfate