Ceroid pigment deposition in circulating blood monocytes and T lymphocytes in Hermansky-Pudlak syndrome: an ultrastructural study.
An electron microscopic study of peripheral leukocytes obtained from a 39 year old woman with Hermansky-Pudlak syndrome was performed. Ceroid pigment granules were found within the lysosomes in 3.5% of monocytes and 5.4% of lymphocytes. Infrequently, pigment granules were also found in the parallel tubular arrays of lymphocytes. The lymphocytes containing ceroid pigment granules were confirmed to be T cells by immunoelectron microscopy. It was speculated that intralysosomal accumulation of ceroid pigment granules in Hermansky-Pudlak syndrome may be due to lysosomal dysfunction.
Sakuma
T
T
Department of Pathology, Iwate Prefectural Central Hospital, Morioka, Japan.
Monma
N
N
Satodate
R
R
Satoh
T
T
Takeda
R
R
Kuriya
S
S
D000328:Adult; D016115:Albinism, Oculocutaneous / Q000276:immunology / Q000473:pathology*; D002566:Ceroid / Q000097:blood*; D005260:Female; D006801:Humans; D016253:Microscopy, Immunoelectron; D009000:Monocytes / Q000737:chemistry / Q000648:ultrastructure*; D013601:T-Lymphocytes / Q000737:chemistry / Q000648:ultrastructure*
D002566:Ceroid