Molecular mapping of the putative gonadoblastoma locus on the Y chromosome.
Based on the high incidence of gonadoblastoma in females with XY gonadal dysgenesis or 45,X/46,XY mosaicism, the existence of a susceptibility locus on the Y chromosome (GBY) has been postulated. We attempted to map GBY by making use of a recently developed dense map of Y-chromosomal sequence-tagged sites (STSs). In two female patients with gonadoblastoma, small marker chromosomes contained portions of the Y chromosome, and a single region of overlap could be defined extending from probe pDP97 in interval 4B, which contains the centromere, to marker sY182 in interval 5E of the proximal long arm. This interval is contained in a YAC contig that comprises approximately 4 Mb of DNA. Our findings confirm the previous localization of GBY and greatly refine it. The localization of GBY overlaps with the region to which a putative growth determinant, GCY, was recently assigned.
Salo
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P
Department of Medical Genetics, University of Helsinki, Finland.
Kääriäinen
H
H
Petrovic
V
V
Peltomäki
P
P
Page
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de la Chapelle
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D002648:Child; D004392:Dwarfism / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics*; D018238:Gonadoblastoma / Q000235:genetics*; D006801:Humans; D009030:Mosaicism / Q000235:genetics; D009857:Oncogenes; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics* / Q000648:ultrastructure