A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation.
Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.
Takatsu
T
T
Biomedical Research Laboratories, Sankyo Co., Ltd, Tokyo 140, Japan.
Takahashi
M
M
Kawase
Y
Y
Enokita
R
R
Okazaki
T
T
Matsukawa
H
H
Ogawa
K
K
Sakaida
Y
Y
Kagasaki
T
T
Kinoshita
T
T
Nakajima
M
M
Tanzawa
K
K
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D005966:Glucuronidase; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D000099175:Heparanase
D004791:Enzyme Inhibitors; D005966:Glucuronidase; D006026:Glycoside Hydrolases; D010880:Piperidines; D000099175:Heparanase; C011353:siastatin