'Non-genotoxic' carcinogens evaluated using the white-ivory assay of Drosophila melanogaster.
Seven carcinogenic compounds (urethane, ethionine, auramine O, safrole, amitrole, acetamide and thioacetamide) were tested using the white-ivory (Wi) assay of Drosophila melanogaster. These compounds were chosen because they were considered as Ames-test negative but produced positive results in the yeast DEL assay, which estimates the introduction of intrachromosomal recombination. Only one compound, urethane, produced positive results in the Wi assay, while the remaining were classified as negative. These results indicate that, in contrast with which has been postulated in yeast, these carcinogens do not induce any event associated to intrachromosomal recombination in D. melanogaster.
Consuegra
S
S
Area de Genetica, Departamento de Biologia Funcional, Universidad de Oviedo, Spain.
Ferreiro
J A
JA
Sierra
L M
LM
Comendador
M A
MA
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004331:Drosophila melanogaster; D008297:Male; D011995:Recombination, Genetic / Q000187:drug effects
D002273:Carcinogens