title: Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients.
abstract: We report the cytogenetic study of 9 colorectal tumors arising in patients with hereditary non-polyposis colorectal cancer (HNPCC). According to the cytogenetic classification of colorectal tumors previously proposed by us, 2 cases were of the trisomic type, 2 were of the monosomic type, and 5 had a normal karyotype. This represents a significant excess of tumors with normal karyotype in HNPCC tumors (56%) compared to sporadic cases (10/184 = 5%).
authors.affiliation: Laboratoire de Cytogénétique Moléculaire et Oncologie, Institut Curie, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Muleris
authors.forename: A M
authors.initials: AM
authors.lastname: Dutrillaux
authors.forename: S
authors.initials: S
authors.lastname: Olschwang
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000473:pathology; D004260:DNA Repair / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D009857:Oncogenes; D014314:Trisomy