[Cytochrome P-450 in tumors and during carcinogenesis].
The current data concerning regulation of cytochrome P-450 isoforms in tumours and during carcinogenesis are reviewed. These findings can be summarized as follows: (i) the total level of cytochrome P-450 in tumours is generally decreased in comparison with homologous normal tissues; (ii) this decrease is observed during both the transformation and progression of the tumour; (iii) individual isoforms of cytochrome P-450 in tumours and pretumour cell clones are expressed in different ways and can thus be regarded as markers for identifying various stages of carcinogenesis.
Kobliakov
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D000818:Animals; D014408:Biomarkers, Tumor; D002478:Cells, Cultured; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000201:enzymology*; D011230:Precancerous Conditions / Q000201:enzymology
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System