title: Positive thyroid cancer scintigraphy using technetium-99m methoxyisobutylisonitrile.
abstract: The aim of the study was to evaluate the possibility of detecting thyroid cancer recurrences without the need for withdrawal of thyroid suppressive treatment. Upper-body or whole-body scintigraphy was performed in a group of 200 patients evaluated for differentiated thyroid cancers in 1993 and 1994 using technetium-99m sestamibi. Scans were performed 20-30min following i.v. administration of 500MBq of 99mTc-methoxyisobutylisonitrile (MIBI). Bone and lung metastases were detected with very high sensitivity and specificity, with a very high predictive value of negative results and a somewhat lower predictive value of positive results. The sensitivity and specificity of findings in the neck were lower but the predictive value of negative results was high. Whole-body scans with 99mTc-MIBI are a useful tool in the follow-up of patients with differentiated thyroid cancer, for the detection of distant metastatic lesions.
authors.affiliation: Clinic of Nuclear Medicine, 2nd Medical School, Charles University, Institute of Endocrinology, 150 18 Praha 5 Motol, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Nĕmec
authors.forename: O
authors.initials: O
authors.lastname: Nývltová
authors.forename: T
authors.initials: T
authors.lastname: Blazek
authors.forename: P
authors.initials: P
authors.lastname: Vlcek
authors.forename: P
authors.initials: P
authors.lastname: Racek
authors.forename: Z
authors.initials: Z
authors.lastname: Novák
authors.forename: M
authors.initials: M
authors.lastname: Preiningerová
authors.forename: M
authors.initials: M
authors.lastname: Hubácková
authors.forename: M
authors.initials: M
authors.lastname: Krízo
authors.forename: J
authors.initials: J
authors.lastname: Zimák
authors.forename: R
authors.initials: R
authors.lastname: Bílek
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*
chemical_list: D017256:Technetium Tc 99m Sestamibi