Serial transplantation in SCID mice of an epidermodysplasia verruciformis-associated squamous cell carcinoma without alteration of its histological and virological features.
An epidermodysplasia verruciformis-associated squamous cell carcinoma was xenografted to a SCID mouse, and the resultant tumor was transplanted through mice for 10 generations. Histological and virological features, with replication of about a thousand copies of the papillomavirus DNA, were the same in both the original carcinoma and the transplanted tumors.
Adachi
A
A
Laboratory of Viral Oncology, Research Institute, Aichi Cancer Center, Nagoya 464, Japan.
Kiyono
T
T
Taguchi
O
O
Ohashi
M
M
Ishibashi
M
M
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology* / Q000601:surgery / Q000821:virology; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D004819:Epidermodysplasia Verruciformis / Q000235:genetics / Q000473:pathology* / Q000601:surgery / Q000821:virology; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D027383:Papillomaviridae / Q000235:genetics / Q000502:physiology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery / Q000821:virology; D014183:Transplantation, Heterologous
D004273:DNA, Neoplasm; D004279:DNA, Viral