Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA.
Cloned cDNA encoding a putative member of GABA receptor rho-subunit class was isolated from rat-retina-mRNA-derived libraries. The cDNA encodes a signal peptide of 21 amino acids followed by the mature rho 3 subunit sequence of 443 amino acids. The proposed amino acid sequence exhibits 63 and 61% homology to the previously-reported human rho 1 and rat rho 2 sequences, respectively. Northern blot analysis demonstrated the expression of mRNA for rho 3 subunit in retina.
Ogurusu
T
T
Department of Computer and Information Science, Faculty of Engineering, Iwate University, Morioka, Japan.
Shingai
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D021382:Protein Sorting Signals / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D018079:Receptors, GABA / Q000737:chemistry / Q000235:genetics*; D011963:Receptors, GABA-A; D012160:Retina / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D018076:DNA, Complementary; C528240:Gabrr3 protein, rat; D021382:Protein Sorting Signals; D012333:RNA, Messenger; D018079:Receptors, GABA; D011963:Receptors, GABA-A