title: Novel prostanoid thromboxane A2 agonists.
abstract: The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 10 times more potent than the standard TP-receptor against U 46619.
authors.affiliation: Research Laboratories of Schering AG, Berlin, Germany.
authors.forename: K D
authors.initials: KD
authors.lastname: Joachim
authors.forename: U
authors.initials: U
authors.lastname: Klar
authors.forename: A
authors.initials: A
authors.lastname: Pletsch
authors.forename: H
authors.initials: H
authors.lastname: Rehwinkel
authors.forename: W
authors.initials: W
authors.lastname: Skuballa
mesh_terms: D001792:Blood Platelets / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011457:Prostaglandins D / Q000138:chemical synthesis / Q000494:pharmacology*; D017482:Receptors, Thromboxane / Q000378:metabolism; D013928:Thromboxane A2 / Q000819:agonists*
chemical_list: C098307:9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor-5,13-prostadienoic acid; D011457:Prostaglandins D; D017482:Receptors, Thromboxane; D013928:Thromboxane A2