title: [Directed search for streptomycetes that are producers of ionophoric antibiotics].
abstract: Streptomyces producing ionophore antibiotics were searched for in various natural substrata, such as soil, sea water, and coastline sea mud, in many geographical regions. A total of 393 Streptomyces strains were isolated, 308 of which proved to be capable of producing antibiotics; 135 of these contained water-insoluble antibiotically active substances in the mycelium. Studies by radioindication, spectrophotometry, and potentiometry demonstrated that these partially purified hydrophobic antibiotics possessed ionophore properties. Selectivity to monovalent potassium and ammonium cations seems to be a characteristic feature of hydrophobic antibiotics derived from Streptomyces differing them from other bacteria.
authors.forename: A N
authors.initials: AN
authors.lastname: Sverdlova
authors.forename: M V
authors.initials: MV
authors.lastname: Nefelova
authors.forename: E I
authors.initials: EI
authors.lastname: Volkova
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Mukhanova
authors.forename: A A
authors.initials: AA
authors.lastname: Likhacheva
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Zaretskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Shaburova
authors.forename: M N
authors.initials: MN
authors.lastname: Semenenko
authors.forename: L G
authors.initials: LG
authors.lastname: Iaglova
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000378:metabolism; D007476:Ionophores / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011199:Potentiometry; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D012988:Soil Microbiology; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*; D014871:Water Microbiology
chemical_list: D000900:Anti-Bacterial Agents; D007476:Ionophores; D000644:Quaternary Ammonium Compounds; D011188:Potassium