Efficacy of SAD (Berne) rabies vaccine given by the oral route in two species of jackal (Canis mesomelas and Canis adustus).
Eight black-backed jackals (Canis mesomelas) and seven side-striped jackals (Canis adustus) were given SAD (Berne) rabies vaccine by direct oral instillation. Three different vaccine doses were used: 10(6.3), 10(6.8) and 10(7.5) median tissue culture infectious doses. Two additional jackals were given vaccine in chicken heads. One group of jackals was challenged with a lethal dose of jackal-derived rabies virus 1 mo after vaccination and a second group 12 mo after vaccination. All 17 vaccinated jackals developed high and persistent serum neutralizing antibody titers. All challenged jackals resisted a lethal dose of rabies virus, whereas three control jackals given the same challenge succumbed to rabies.
Bingham
J
J
Veterinary Research Laboratory, Causeway, Harare, Zimbabwe.
Kappeler
A
A
Hill
F W
FW
King
A A
AA
Perry
B D
BD
Foggin
C M
CM
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002335:Carnivora; D002460:Cell Line; D006224:Cricetinae; D009500:Neutralization Tests / Q000662:veterinary; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage; D011820:Rabies virus / Q000276:immunology; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D015030:Zimbabwe
D000914:Antibodies, Viral; D011819:Rabies Vaccines