title: Why two heads are better.
abstract: The tandem SH2 domains of the ZAP-70 kinase complexed with a doubly phosphorylated ligand reveal a mechanism for building a high-affinity interaction with very low non-specific binding.
authors.affiliation: Howard Hughes Medical Institute, Children's Hospital, Boston, MA, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Mayer
mesh_terms: D017252:CD3 Complex / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011505:Protein-Tyrosine Kinases / Q000737:chemistry* / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000378:metabolism; D051746:ZAP-70 Protein-Tyrosine Kinase; D018909:src Homology Domains
chemical_list: D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human