Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni.
Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed.
Tonelli
S M
SM
Grupo Interdepartamental de Estudos sobre Esquistossomose, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Goulart
E M
EM
Tonelli
E
E
Coelho
P M
PM
D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D008099:Liver / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010073:Oxamniquine / Q000008:administration & dosage / Q000633:toxicity*; D011223:Praziquantel / Q000008:administration & dosage / Q000633:toxicity*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000401:mortality; D012556:Schistosomicides / Q000008:administration & dosage / Q000506:poisoning*
D012556:Schistosomicides; D010073:Oxamniquine; D011223:Praziquantel