title: Double cancer in different hepatic lobes: hepatocellular and cholangiocellular carcinoma.
abstract: OBJECTIVE
  Hepatic tumors with elements of both hepatocellular and cholangiocellular carcinoma are occasionally encountered; however, the independent and simultaneous occurrence of different epithelial malignant tumors in different lobes is rare. This is a case report of resected double cancer in different lobes of the liver.
  
  
  METHODS
  A 73 year old Japanese man, with hepatic mass and a history of peritonitis and hepatitis, underwent laparotomy and hepatic resection of the posterior inferior and the left lateral segment, and cholecystectomy for cholecystlithiasis with left-sided gallbladder at our hospital in 1991.
  
  
  RESULTS
  The tumor, located in the posterior inferior segment, a yellow-white, round, highly circumscribed mass with a thick capsule, was about 9.0 by 8.0 cm in size. The other tumor located in the left lateral segment, grayish-white on the cut section, was approximately 5.0 by 4.0 cm.
  
  
  CONCLUSIONS
  In our case, it is unlikely the tumor in the right lobe metastasized to the left lobe and transformed into a different type. The two tumors showed clearly different microscopic features. Improved imaging will increase the frequency and number of double cancer diagnosis. This additional data may shed light on the pathogenesis and etiology of double cancer.
authors.affiliation: Second Department of Surgery, Gunma University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohwada
authors.forename: O
authors.initials: O
authors.lastname: Yoshihiro
authors.forename: S
authors.initials: S
authors.lastname: Iwazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tanahashi
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: I
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawashima
authors.forename: S
authors.initials: S
authors.lastname: Nakaura
authors.forename: Y
authors.initials: Y
authors.lastname: Iino
authors.forename: Y
authors.initials: Y
authors.lastname: Morishita
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000601:surgery; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000601:surgery; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000601:surgery; D014057:Tomography, X-Ray Computed