title: Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis.
abstract: The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.
authors.affiliation: Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Janot
authors.forename: J
authors.initials: J
authors.lastname: Klijanienko
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: J P
authors.initials: JP
authors.lastname: Mamet
authors.forename: F
authors.initials: F
authors.lastname: de Braud
authors.forename: A K
authors.initials: AK
authors.lastname: El-Naggar
authors.forename: J P
authors.initials: JP
authors.lastname: Pignon
authors.forename: B
authors.initials: B
authors.lastname: Luboinski
authors.forename: E
authors.initials: E
authors.lastname: Cvitkovic
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D016001:Confidence Intervals; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D015999:Multivariate Analysis; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D016196:S Phase; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007633:Keratins