C4 null alleles in a Swedish population.
The distribution of C4 null alleles (C4Q0) was studied in a Swedish population comprising 410 male individuals from Stockholm County and Uppsala City. The prevalances of homozygous C4A*Q0 and C4B*Q0 determined by analysing the gene products in serum were 5.0 and 5.6%, respectively, in the Stockholm population and 4.0% each in the Uppsala population. These values are higher than those previously reported from other Caucasian populations. The finding reflects a different genetic composition of the Swedish population and may have relevance to the disease spectrum in this population as compared to other Caucasian populations.
Nityanand
S
S
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Dawkins
R L
RL
Lithell
H
H
Holm
G
G
Lefvert
A K
AK
D000328:Adult; D000483:Alleles; D015934:Complement C4a / Q000235:genetics*; D015935:Complement C4b / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D013548:Sweden
D015934:Complement C4a; D015935:Complement C4b