title: [Coagulopathic hemorrhages in the surgical treatment of cancer patients].
abstract: The hemostasis system was examined before surgery, during the principle stages of the intervention, and in the immediate postoperative period in 280 patients with various malignant tumors. The volume of blood loss during the operation varied from 280 to 14,000 ml. The studies demonstrated that blood loss due to traumatic surgical interventions is the principal factor causing the most profound disorders in the hemostasis system leading to the development of grave coagulopathic hemorrhages in cancer patients. Coagulopathic bleedings most frequently develop at a blood loss of more than 3,000 ml and course as variants and stages of the disseminated intravascular coagulation (DIC) syndrome or hemodilution coagulopathy. A massive blood loss was found to be detrimental primarily for the platelet component of the hemostasis system; besides thrombocytopenia, the aggregability of these cells reduced, this being conducive to development of hemorrhages from the small vessels. Laboratory signs of acute DIC syndrome diagnosed during surgery were shown to anticipate its clinical manifestation. A working classification of surgical hemorrhages and rapid methods for their diagnosis have been developed.
authors.forename: A V
authors.initials: AV
authors.lastname: Madzhuga
authors.forename: O V
authors.initials: OV
authors.lastname: Somonova
authors.forename: A L
authors.initials: AL
authors.lastname: Elizarova
authors.forename: V M
authors.initials: VM
authors.lastname: Astakhova
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006487:Hemostasis; D006801:Humans; D007431:Intraoperative Complications / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery