Persistence: a new statistic for characterizing ion-channel activity.
We introduce and illustrate by examples a new statistical technique, the persistence function, for characterizing ion-channel activity in a single-channel patch-clamp recording. Persistence is a function of both current and time. It is the probability that the current is at a given level (conditional on it having been at that level at an earlier time). Viewed as a function of current it exhibits the prominent conductance levels present in the recording, and viewed as a function of time for a conductance level it portrays the kinetics at that level.
Fredkin
D R
DR
Department of Physics, University of California, San Diego, USA.
Rice
J A
JA
Colquhoun
D
D
Gibb
A J
AJ
D007473:Ion Channels; D007700:Kinetics; D008954:Models, Biological; D018408:Patch-Clamp Techniques; D016194:Receptors, N-Methyl-D-Aspartate; D013223:Statistics as Topic
D007473:Ion Channels; D016194:Receptors, N-Methyl-D-Aspartate