Trisomy 21 in acute myeloid leukemia.
We report two cases of acute myeloid leukemia (AML), constitutionally normal, with trisomy 21. Trisomy 21 does not often occur as a sole numerical karyotypic abnormality in AML leukemia. The possible prognostic significance of the finding in acute leukemia is discussed.
Wei
C H
CH
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Yu
I T
IT
Tzeng
C H
CH
Fan
F S
FS
Hsieh
R K
RK
Chiou
T J
TJ
Liu
J H
JH
Chen
P M
PM
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D004314:Down Syndrome; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D015255:Idarubicin / Q000008:administration & dosage; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage
D003561:Cytarabine; D008942:Mitoxantrone; D006918:Hydroxyurea; D015255:Idarubicin