Basic actions of transforming growth factor-alpha and related peptides.
Transforming growth factor-alpha (TGF-alpha) and related peptides have been implicated in a wide range of biological activities, including cell growth, differentiation and acid inhibition. This chapter reviews the roles of TGF-alpha in the stomach, the insights gained into the action of the TGF-alpha family of growth factors from the study of polarized epithelial cells and the confirmation of events mediated by the epidermal growth factor receptor (EGFR) by the study of mice in which the EGFR has been disrupted by homologous recombination.
Coffey
R J
RJ
Department of Medicine, Vanderbilt University, Nashville, TN 37232-2279, USA.
Gangarosa
L M
LM
Damstrup
L
L
Dempsey
P J
PJ
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010455:Peptides / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013270:Stomach / Q000502:physiology*; D016211:Transforming Growth Factor alpha / Q000235:genetics / Q000502:physiology*
D010455:Peptides; D016211:Transforming Growth Factor alpha; D066246:ErbB Receptors