title: Long-term changes in entorhinal-dentate evoked potentials induced by electroconvulsive shock seizures in rats.
abstract: Entorhinal-dentate evoked potentials were measured in rats before and after: (1) eight electroconvulsive shock (ECS) seizures, or (2) matched handling. In animals that received ECS, evoked potentials were significantly enhanced, as evidenced by a long-lasting increase in the amplitude of the population spike. This increase in population-spike amplitude lasted for at least 3 months after the last ECS trial. No evoked-potential changes were observed in the subjects that received matched handling. These data suggest that ECS seizures produce long-lasting, perhaps permanent, changes in the brain.
authors.affiliation: Bloorview Epilepsy Program, University of Toronto, Ont., Canada.
authors.forename: W M
authors.initials: WM
authors.lastname: Burnham
authors.forename: G A
authors.initials: GA
authors.lastname: Cottrell
authors.forename: D
authors.initials: D
authors.lastname: Diosy
authors.forename: R J
authors.initials: RJ
authors.lastname: Racine
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D004597:Electroshock; D018728:Entorhinal Cortex / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D008297:Male; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors