title: T-cell responses in photoimmune therapy.
abstract: The extracorporeal inactivation of a lymphocyte rich buffy coat suspension with ultraviolet A light and 8 methoxypsoralen can lead to dramatic clinical improvements following reinfusion of the damaged cells. This therapy is reviewed in the context of the disease it is most commonly used for: cutaneous lymphoma. Studies with cutaneous lymphoma patients have shown an active immune response against purified tumor cells. In addition a mouse model for an impact of therapy on a T-cell lymphoma has demonstrated results that parallel those from clinical studies in humans. The impact of photoimmune therapy on in vivo and in vitro T-cell responses to cutaneous lymphoma is discussed.
authors.affiliation: Dermatology Department, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Heald
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Perez
authors.forename: R L
authors.initials: RL
authors.lastname: Edelson
authors.forename: C L
authors.initials: CL
authors.lastname: Berger
mesh_terms: D000917:Antibody Formation / Q000187:drug effects; D001804:Blood Transfusion, Autologous; D006801:Humans; D018655:Lymphocyte Count / Q000187:drug effects; D017710:Lymphocyte Transfusion; D008223:Lymphoma / Q000276:immunology; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*