title: Cloning and characterization of a novel zinc finger gene in Xp11.2.
abstract: During a systematic search for open reading frames in chromosome band Xp11.2, a novel gene (ZNF157) that encodes a putative 506-amino-acid protein with the sequence characteristics of a zinc-finger-containing transcription factor was isolated. ZNF157 is encoded by four exons distributed over > 20 kb of genomic DNA. The second and third exons contain sequences similar to those of the previously described KRAB-A and KRAB-B domains, motifs that have been shown to mediate transcriptional repression in other members of the protein family. A fourth exon contains 12 zinc finger DNA binding motifs and finger linking regions characteristic of ZNF proteins of the Krüppel family. ZNF157 maps to the telomeric end of a cluster of ZNF genes that includes ZNF21, ZNF41, and ZNF81.
authors.affiliation: Howard Hughes Medical Institute, Stanford University Medical School, California 94305, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Derry
authors.forename: U
authors.initials: U
authors.lastname: Jess
authors.forename: U
authors.initials: U
authors.lastname: Francke
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D005091:Exons; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014960:X Chromosome; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D018076:DNA, Complementary