Kinetic disposition of triclabendazole in buffalo compared to cattle.
Concentrations of triclabendazole sulfoxide and its sulfone metabolite in plasma were measured in buffalo and cross-bred cattle after single intraruminal administration of triclabendazole at two different doses. Plasma concentrations of both metabolites were significantly lower in buffalo than cattle at both doses, which resulted in a smaller area under the concentration-time curve, a lower concentration maximum and a lower relative bioavailability. Thus, the recommended doses of 12 mg/kg body weight for the treatment of bubaline fascioliasis may not be valid for buffalo because of the substantially lower uptake of the drug in this species.
Sanyal
P K
PK
Animal Disease Research Laboratory, National Dairy Development Board, Gujarat, India.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002020:Buffaloes / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D008297:Male; D012417:Rumen / Q000378:metabolism; D013045:Species Specificity; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole