Alterations in skeletal muscle related to short-term impaired physical mobility.
The purpose of this investigation was to describe and compare two methods of recovery of atrophied skeletal muscle following short-term impaired physical mobility. An animal model was used to study morphologic adaptations of atrophied soleus and plantaris muscles to the effects of 7 days of hind-limb suspension (HS) followed by either sedentary recovery or run training during a 28-day recovery period. Significant atrophy, demonstrated by decreased mean fiber area (MFA, in square micrometers), occurred during the 7-day period of HS. During recovery, MFA returned to control values 14 days earlier in the sedentary compared with the trained groups. Runs training following short-term atrophy induced by HS did not result in the high levels of frank muscle damage and type IIC fibers previously reported following long-term (28-day) atrophy.
Kasper
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CE
School of Nursing, University of California, Los Angeles 90095-6918, USA.
Maxwell
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LC
White
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TP
D000704:Analysis of Variance; D000818:Animals; D001284:Atrophy / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006614:Hindlimb; D006651:Histocytochemistry; D007103:Immobilization / Q000009:adverse effects*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013997:Time Factors