Sodium depletion prevents albuminuria in hypertensive rats.
The effect of short term (8 weeks) sodium (Na+) depletion and its repletion on glomerular synthesis of heparan sulfate and urinary excretions of albumin, total protein, heparan sulfate, Na+ and potassium (K+) was studied in spontaneous hypertensive rats (SHR) and their control normotensive Wistar-Kyoto rats (WKY). Na+ depletion in SHRs significantly increased the synthesis of glomerular heparan sulfate and decreased urinary excretions of albumin, Na+ and heparan sulfate when compared with the Na+ repleted group. In WKY rats, Na+ depletion did not cause any of the above changes. These data suggest that Na+ depletion prevents the urinary loss of protein through preservation of glomerular heparan sulfate only in SHRs.
Jyothirmayi
G N
GN
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
Alluru
L
L
Fine
J M
JM
Reddi
A S
AS
D000419:Albuminuria / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004326:Drinking; D006025:Glycosaminoglycans / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism / Q000652:urine; D006973:Hypertension / Q000150:complications* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000502:physiology* / Q000652:urine
D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D012964:Sodium