title: Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS.
abstract: The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation.
authors.affiliation: Department of Obstetrics and Gynaecology, Pediatrics and Physiology, University of Alberta, Edmonton, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Zakar
authors.forename: D M
authors.initials: DM
authors.lastname: Olson
mesh_terms: D000650:Amnion / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D012333:RNA, Messenger; D011451:Prostaglandin-Endoperoxide Synthases