Derivative (6)t(1;6)(q22;p21) revealed in bone marrow cells by FISH 9 months before diagnosis of acute T-lymphoblastic leukemia.
A chromosomal clone with unbalanced translocation resulting in partial trisomy of segment 1q22-qter and partial monosomy of segment 6p21-pter was revealed by fluorescence in situ hybridization (FISH) using a panel of different whole chromosome painting probes. The pathologic clone appeared after sequential chemotherapy treatment for AML-M5 when the patient was in complete remission before development of T-ALL. However, this clone was present during the whole period of treatment for T-ALL. The clone remained the only chromosomal aberration found. Breakpoints were detected more easily and more precisely with the use of the FISH technique than with G-banding only.
Michalová
K
K
3rd Medical Department, General Faculty Hospital, 1st Medical Faculty of Charles University, Prague, Czech Republic.
Lemez
P
P
Bartsch
O
O
Brĕzinová
J
J
Zemanová
Z
Z
Jelínek
J
J
Horák
I D
ID
Burke
P J
PJ
D001853:Bone Marrow / Q000473:pathology*; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014178:Translocation, Genetic