title: Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.
abstract: A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 microM, respectively.
authors.affiliation: Reseaarch Center for Biological Function, The Kitasato Institute, Tokyo 108, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Enomoto
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: R
authors.initials: R
authors.lastname: Masuma
authors.forename: T
authors.initials: T
authors.lastname: Kawakubo
authors.forename: K
authors.initials: K
authors.lastname: Tomosawa
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000470:Alkaloids; D010975:Platelet Aggregation Inhibitors; C098363:herquline B