title: Fetal urinary insulin-like growth factor I and binding protein 3 in bilateral obstructive uropathies.
abstract: Fetal urinary concentrations of insulin-like growth factor I (UIGF-I) and binding protein 3 (UIGFBP-3) were determined in patients with prenatal diagnosis of bilateral obstructive uropathy. Patients were retrospectively assigned to three groups, on the basis of outcome: group 1, termination of pregnancies (n = 11) with sonographic evidence of severe oligohydramnios or renal dysplasia, confirmed at histological examination; group 2, patients (n = 10) with postnatal plasma creatinine > 50 mumol/l at the age of 1 year (1 yr-pCreat); and group 3, patients (n = 16) with 1 yr-pCreat < or = mumol/l. The results show a significant increase in UIGF-I and UIGFBP-3 in groups 1 (18,159 +/- 9083 pg/ml; 2657 +/- 669 ng/ml) and 2 (1574 +/- 847 pg/ml; 176 +/- 50 ng/ml) in comparison with group 3 (35 +/- 6 pg/ml; 21 +/- 2 ng/ml). UIGF-I and UIGFBP-3 were significantly correlated with postnatal plasma creatinine, and were both sensitive (90 per cent; 80 per cent) and specific (88 per cent; 88 per cent) for prediction of elevated 1 yr-pCreat (> 50 mumol/l). Fetal urinary IGF-I and IGFBP-3 are increased in severe fetal bilateral obstructive uropathy, possibly reflecting tubular dysfunction or/and increased synthesis consequent upon fetal kidney injury. Their predictive value for postnatal renal function needs further assessment.
authors.affiliation: Département de Physiologie, Hôpital-Necker-Enfants Malades, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Bussieres
authors.forename: K
authors.initials: K
authors.lastname: Laborde
authors.forename: J C
authors.initials: JC
authors.lastname: Souberbielle
authors.forename: F
authors.initials: F
authors.lastname: Muller
authors.forename: M
authors.initials: M
authors.lastname: Dommergues
authors.forename: C
authors.initials: C
authors.lastname: Sachs
mesh_terms: D004573:Electrolytes / Q000652:urine; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000652:urine*; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000652:urine*; D007334:Insulin-Like Growth Factor I / Q000652:urine*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging / Q000652:urine; D014570:Urologic Diseases / Q000000981:diagnostic imaging / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D004573:Electrolytes; D018972:Insulin-Like Growth Factor Binding Protein 3; D001613:beta 2-Microglobulin; D007334:Insulin-Like Growth Factor I