Human testis specifically expresses a homologue of the rodent T lymphocytes RT6 mRNA.
A human homologue of the rodent T cell mono ADP-ribosyl transferase RT6 mRNA was identified by a systematic analysis of human testis transcripts. This messenger encodes for a precursor protein of 367 aa (MW: 41.5 kDa) which exhibits a peptide signal, consensus domains for mono ADP-ribosyl transferase and a C-terminal part characteristic of glycophosphatidyl inositol anchored protein. This mRNA, transcribed from a gene localized in 4q13-q21, is not expressed in white blood cells but is specific for human testis in which it is likely to correspond to a new ADP-ribosyl transferase.
Lévy
I
I
Unite INSERM 99, Hopital Henri Mondor, Creteil, France.
Wu
Y Q
YQ
Roeckel
N
N
Bulle
F
F
Pawlak
A
A
Siegrist
S
S
Mattéi
M G
MG
Guellaën
G
G
D036002:ADP Ribose Transferases; D000595:Amino Acid Sequence; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D058851:GPI-Linked Proteins; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000737:chemistry; D013737:Testis / Q000737:chemistry / Q000378:metabolism*
D000945:Antigens, Differentiation, T-Lymphocyte; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D011506:Proteins; D012333:RNA, Messenger; D004247:DNA; D036002:ADP Ribose Transferases; D011065:Poly(ADP-ribose) Polymerases; C449301:ART1 protein, human; C090163:Art2b protein, rat