title: Capacity of Helicobacter pylori to generate ionic gradients at low pH is similar to that of bacteria which grow under strongly acidic conditions.
abstract: Helicobacter pylori colonized the highly acidic human gastric mucosa. At pH 3.0 to 7.0, this bacterium maintained a nearly neutral internal pH. Its membrane potential changed reciprocally with the pH gradient so that a relatively constant proton motive force was maintained. Possible, the capacity to maintain an appropriate transmembrane ionic gradient at a low pH contributes to the pathogenic propensities of this bacterium.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, Stanford University, California, 94305.
authors.forename: A
authors.initials: A
authors.lastname: Matin
authors.forename: E
authors.initials: E
authors.lastname: Zychlinsky
authors.forename: M
authors.initials: M
authors.lastname: Keyhan
authors.forename: G
authors.initials: G
authors.lastname: Sachs
mesh_terms: D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013270:Stomach / Q000382:microbiology
chemical_list: D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone