[Pharmacokinetics of ciprofloxacin injection in healthy volunteers].
The results of pharmacokinetic study of intravenous infusion ciprofloxacin in normal male volunteers were presented. Serum and urine concentrations of ciprofloxacin were determined by high performance liquid chromatography. The single dose 200 mg iv concentration-time curve fitted to two-compartment open model in eight volunteers. Its main pharmacokinetic parameters were: C0 4.61 +/- 1.64 mg/L, t1/2 beta 3.86 +/- 0.67 h and AUC 7.06 +/- 1.21 mg/L.h. The urinary recovery rate of ciprofloxacin over 12 h after dosing was 60.85%.
Hong
Z
Z
Wang
Y
Y
Xu
N
N
Zhang
H
H
Liang
D
D
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male
D002939:Ciprofloxacin