The neurochemical and metabolic cascade following brain injury: moving from animal models to man.
Experimental traumatic brain injury produces a series of cellular events contributing to a neurochemical and neurometabolic cascade. This cascade is defined by the release of neurotransmitters resulting in a massive ionic flux, which, consequently, produces an increase in glycolysis. This increase in glycolysis is followed by a metabolic diaschisis, which is related to the degree and extent of behavioral deficits. Clinical efforts have now determined that a similar cascade occurs in human head injury, validating the animal model as well as providing new assessment strategies for the management and treatment of brain injury.
Hovda
D A
DA
Department of Surgery, UCLA School of Medicine 90024, USA.
Lee
S M
SM
Smith
M L
ML
Von Stuck
S
S
Bergsneider
M
M
Kelly
D
D
Shalmon
E
E
Martin
N
N
Caron
M
M
Mazziotta
J
J
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D004195:Disease Models, Animal; D006019:Glycolysis; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D013045:Species Specificity
D018377:Neurotransmitter Agents