title: A tick homologue of the human DNA helicase II 70-kDa subunit.
abstract: A clone isolated from a Rhipicephalus appendiculatus salivary gland cDNA library encodes a homologue of the 70-kDa subunit of the mammalian Ku protein, an ATP-dependent DNA helicase. The tick homologue appears to be more closely related to the mammalian protein than to the only other p70 homologue reported in arthropods, the inverted repeat binding protein (IRBP) in the fruitfly, Drosophila melanogaster.
authors.affiliation: NERC institute of Virology and Environmental Microbiology, Oxford, UK.
authors.forename: G C
authors.initials: GC
authors.lastname: Paesen
authors.forename: P M
authors.initials: PM
authors.lastname: Zanotto
authors.forename: P A
authors.initials: PA
authors.lastname: Nuttall
mesh_terms: D000251:Adenosine Triphosphatases / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004265:DNA Helicases; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005260:Female; D015723:Gene Library; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009687:Nuclear Proteins; D010802:Phylogeny; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D012469:Salivary Glands / Q000201:enzymology; D017386:Sequence Homology, Amino Acid; D013987:Ticks / Q000201:enzymology / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D009687:Nuclear Proteins; D000251:Adenosine Triphosphatases; D004265:DNA Helicases