Chronic relapsing neuropathy associated with Castleman's disease (angiofollicular lymph node hyperplasia).
We report a 17-year-old patient who presented a chronic relapsing sensorimotor demyelinating neuropathy with 6 relapses over a 7-year period, preceding by 4 years the diagnosis of a multicentric angiofollicular lymph node hyperplasia. A role for Epstein-Barr virus (EBV) as a trigger of the neuropathy may be suggested by the presence of EBV DNA in the biopsied abdominal abdominal adenopathies. This unusual reported association seems to have a better prognosis than the known chronic progressive form of neuropathy associated with Castleman's disease and the Crow-Fukase syndrome.
Vingerhoets
F
F
Service de Neurologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Kuntzer
T
T
Delacrétaz
Steck
A J
AJ
Knecht
H
H
Bogousslavsky
J
J
Meier
C
C
Regli
F
F
D000293:Adolescent; D001247:Asthenia / Q000209:etiology; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D003711:Demyelinating Diseases / Q000150:complications* / Q000473:pathology / Q000821:virology; D004594:Electrophysiology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008297:Male; D008643:Mesentery; D012008:Recurrence; D013497:Sural Nerve / Q000473:pathology
D004279:DNA, Viral