Beta 2-microglobulin has a strong affinity to bone marrow and synovium: an experimental study.
This experimental study was undertaken to clarify whether beta 2-microglobulin (B2M) deposits are the cause or merely the consequence of arthritis or osseous changes in chronic renal failure. Twenty-one heminephrectomized, male inbred DBA/1J mice were divided into 3 groups of 6 animals and a group of 3 mice. Collagen arthritis was produced by the intradermal injection of an emulsion of bovine collagen type II and complete Freund's adjuvant in groups 1, 2 and 4. Human urine derived B2M, 100 micrograms and 300 micrograms was then given subcutaneously to group 1 for up to 10 days and also to the 6 mice in group 3 without arthritis. Three mice in group 4 received horse myoglobin 100 micrograms daily for 1, 3 and 5 days as a control. Regardless of the presence of arthritis or osseous changes, B2M was deposited predominantly in the bone marrow and synovium of the B2M treated mice in groups 1 and 3. On the other hand, group 2 which had not been given B2M had no deposits. Deposits of myoglobin were not seen in group 4 mice. These findings suggest that B2M is deposited in the bone marrow and synovium as a primary event.
Ono
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Ono Clinic, Fukuoka, Japan.
Ono
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Ono
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D000818:Animals; D001169:Arthritis, Experimental / Q000150:complications / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013583:Synovial Membrane / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001613:beta 2-Microglobulin