title: Systemic lupus erythematosus: clinical manifestations and immunological parameters in 194 patients. Subgroup classification of SLE.
abstract: We analysed the prevalence of clinical manifestations and immunological parameters in 194 patients with SLE and classified them in subgroups according to age at onset, gender and type of antibodies: we detected significant differences in the various subgroups. In SLE that initiated before the age of 20 years, the most frequent manifestation at onset was malar rash (25% vs 14%). During the course of the disease, this group had a greater prevalence of malar rash (70% vs 45%), mouth ulcers (48% vs 29%), and convulsions or psychosis (35% vs. 17%). In SLE that initiated late in life (after 50 years) malar rash was less frequent at onset and during subsequent evolution of the disease (27% vs 45%). The existence of ANA, and elevated values of anti-dsDNA, anti-ENA and antiphospholipid antibodies also differentiated the SLE subgroups with clinical significance.
authors.affiliation: Internal Medicine Service Ntra.Sra.de La Candelaria Hospital, Tenerife, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Antolin
authors.forename: M J
authors.initials: MJ
authors.lastname: Amerigo
authors.forename: A
authors.initials: A
authors.lastname: Cantabrana
authors.forename: A
authors.initials: A
authors.lastname: Roces
authors.forename: P
authors.initials: P
authors.lastname: Jimenez
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001323:Autoantibodies / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D001323:Autoantibodies