title: Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E.
abstract: One of the classical vitamin E deficiency syndromes is nutritional encephalomalacia in broiler chicken. Subject of this study was the influence of dietary fatty acids and vitamin E on phospholipase A2 and alpha-tocopherol concentration in liver, cerebrum and affected cerebellum posthatching. Therefore, chicks were fed either oleic, linoleic or linolenic acid rich fats together with 5, 25, or 125 ppm vitamin E. At the end of 0, 1, 2 and 3 weeks the tocopherol content and phospholipase A2 activity of liver, cerebrum and cerebellum were determined. Dietary fatty acids did not influence tissue alpha-tocopherol and phospholipase A2. In the vitamin E-deficient cerebellum the enzyme activity of cytosolic phospholipase A2 was increased. Due to its low content of vitamin E the cerebellum is the most susceptible tissue to oxidative stress during vitamin E deficiency.
authors.affiliation: Institut für Physiologische Chemie, Tierärztliche Hochschule Hannover, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Fuhrmann
authors.forename: H P
authors.initials: HP
authors.lastname: Sallmann
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D002645:Chickens; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D014810:Vitamin E / Q000378:metabolism* / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism; D017962:alpha-Linolenic Acid / Q000494:pharmacology
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D009829:Oleic Acids; D017962:alpha-Linolenic Acid; D014810:Vitamin E; D019301:Oleic Acid; D019787:Linoleic Acid; D010741:Phospholipases A; D054467:Phospholipases A2