Anaplastic B-cell (Ki-1) lymphoma developing in a patient with polycythemia vera.
The association of lymphoproliferative disorders and polycythemia vera (PV) is extremely rare. Here we report a patient with PV who developed anaplastic B-cell (Ki-1) non-Hodgkin's lymphoma (NHL). The rare occurrence of lymphoproliferative disorder in the course of PV, may indicate that in a minority of patients, clonal expansion of an abnormal pluripotent haemopoetic stem cell could be responsible for both the PV and the NHL.
Steinberg
E
E
Institute of Hematology, Brazilai Medical Center, Ashkelon, Israel.
Ben-Dor
D
D
Lugassy
G
G
D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D002999:Clone Cells / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology; D011087:Polycythemia Vera / Q000473:pathology*
D018906:Antineoplastic Agents, Alkylating