title: Cure for a crisis?
abstract: The first look at the three-dimensional structure of an essential penicillin binding protein from a human pathogen, and its complex with a beta-lactam antibiotic provides hope for the future design of improved antibiotics.
authors.affiliation: Department of Chemistry, University of Groningen, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Thunnissen
authors.forename: B W
authors.initials: BW
authors.lastname: Dijkstra
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D002444:Cefuroxime / Q000737:chemistry / Q000378:metabolism*; D002511:Cephalosporins / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D006602:Hexosyltransferases; D006801:Humans; D008969:Molecular Sequence Data; D002267:Muramoylpentapeptide Carboxypeptidase / Q000737:chemistry* / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism; D010457:Peptidoglycan / Q000737:chemistry / Q000378:metabolism; D010458:Peptidyl Transferases; D013296:Streptococcus pneumoniae / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D002511:Cephalosporins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D010457:Peptidoglycan; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D002444:Cefuroxime