title: [Ventricular fibrillation after administration of adenosine].
abstract: In the submitted case-history the authors describe a hitherto unknown proarrhythmic effect of adenosine. Adenosine was administered on account of supraventricular tachycardia and the undesirable proarrhythmic effect was so-called "sine wave-like tachycardia" and ventricular fibrillation. Proarrhythmia was resistant to electric cardioversion and resuscitation was successful probably only after the breakdown of adenosine. The very short half-life of breakdown of this antiarrhythmic is thus useful not only for antiarrhythmic strategy but, because of the possible occurrence of rare proarrhythmias, adenosine holds a preferential position among other antiarrhythmic drugs.
authors.affiliation: III. interná klinika FN L. Pasteura, Kosice.
authors.forename: J
authors.initials: J
authors.lastname: Pella
authors.forename: B
authors.initials: B
authors.lastname: Stancák
authors.forename: E
authors.initials: E
authors.lastname: Komanová
authors.forename: R
authors.initials: R
authors.lastname: Novotný
mesh_terms: D000241:Adenosine / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006801:Humans; D013617:Tachycardia, Supraventricular / Q000188:drug therapy; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000241:Adenosine