[A case of unresectable gastric cancer responding to combined therapy with intraperitoneal cisplatinum administration and continuous intravenous infusion of 5-fluorouracil].
A 41-year-old woman diagnosed as gastric cancer with peritoneal dissemination was admitted for operation. Exploratory laparotomy was done and a reservoir was implanted with intraperitoneal catheter. At the operation, CDDP (100 mg) was administered intraperitoneally. Four days after the operation, continuous intravenous infusion of 5-FU (250 mg) was carried out. CDDP was administered every four weeks for 6 times and 5-FU continuously for 194 days. Grade 2 toxicity (nausea, vomiting) was noted without myelosuppression and renal disturbance. The general condition of the patient was fairly improved. PS (performance status) improved from Grade 3 to Grade 1. Combined therapy with repeated intraperitoneal CDDP administration and continuous intravenous infusion of 5-FU is effective and safe for gastric cancer with peritoneal dissemination based on biochemical modulation.
Kokufu
I
I
Dept. of Surgery, Kawanishi City Hospital.
Fukuda
I
I
Miyake
Y
Y
Kishimoto
S
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D013274:Stomach Neoplasms / Q000188:drug therapy*
D002945:Cisplatin; D005472:Fluorouracil