title: Structural studies of vinblastine alkaloids by exciton coupled circular dichroism.
abstract: SCF-CI-dipole velocity MO calculations have shown that the bisignate circular dichroic curves of vinblastine/vincristine alkaloids at ca 210 and 220-230 nm are due to exciton coupling between the indoline and indole moieties. Furthermore, a combination of X-ray crystal structure data with MM2 local energy minimization provides a convenient means for estimation of the preferred solution conformation.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Dong
authors.forename: W
authors.initials: W
authors.lastname: Bornmann
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: N
authors.initials: N
authors.lastname: Berova
mesh_terms: D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013053:Spectrophotometry; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000737:chemistry*; D014748:Vinca Alkaloids / Q000737:chemistry*; D014750:Vincristine / Q000737:chemistry
chemical_list: D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine