Eosinophilia associated with proliferation of CD(3+)4-(8-) alpha beta+ T cells with chromosome 16 anomalies.
We describe a patient with eosinophilia and an abnormal CD(3+)4-(8-) alpha beta+ T-cell population. Chromosomal analysis of sorted CD(3+)4-(8-) cells revealed abnormal karyotypes on chromosome 16. In the presence of IL-2 the production of IL-5 from CD(3+)4-(8-) cells was higher than that from CD(3+)4-(8-) cells. Eosinophil survival-enhancing activity in the patient serum was inhibited by a combination of anti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD(3+)4-(8-) cells might cause eosinophilia.
Kitano
K
K
Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Ichikawa
N
N
Mahbub
B
B
Ueno
M
M
Ito
T
T
Shimodaira
S
S
Kodaira
H
H
Ishida
F
F
Kobayashi
H
H
Saito
H
H
Okubo
Y
Y
Enokihara
H
H
Kiyosawa
K
K
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D017252:CD3 Complex / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D002478:Cells, Cultured; D002885:Chromosomes, Human, Pair 16; D004802:Eosinophilia / Q000235:genetics / Q000276:immunology*; D004804:Eosinophils / Q000502:physiology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D015848:Interleukin-5 / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D014178:Translocation, Genetic / Q000276:immunology*
D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D007376:Interleukin-2; D015848:Interleukin-5; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016178:Granulocyte-Macrophage Colony-Stimulating Factor