Fpg and UvrA proteins participate in the repair of DNA lesions induced by hydrogen peroxide in low iron level in Escherichia coli.
The survival of different DNA repair mutant strains of Escherichia coli treated with H2O2 was evaluated in the presence or absence of an iron chelator (dipyridyl). Our results suggest that Fpg and UvrA proteins participate in vivo in the repair of DNA lesions produced by higher H2O2 concentrations in the presence of an iron chelator while UvrB and UvrC proteins seem to be ineffective in the repair of these lesions.
Asad
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Laboratório de Radiobiologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
de Almeida
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CE
Asad
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Felzenszwalb
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I
Leitão
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D015082:2,2'-Dipyridyl / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000187:drug effects / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology*; D016923:Cell Death / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects*; D004268:DNA-Binding Proteins / Q000494:pharmacology*; D043382:DNA-Formamidopyrimidine Glycosylase; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D029968:Escherichia coli Proteins; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007501:Iron / Q000032:analysis; D007502:Iron Chelating Agents / Q000494:pharmacology*; D009154:Mutation; D009699:N-Glycosyl Hydrolases / Q000494:pharmacology*
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D007502:Iron Chelating Agents; D015082:2,2'-Dipyridyl; D006861:Hydrogen Peroxide; D007501:Iron; D009699:N-Glycosyl Hydrolases; D043382:DNA-Formamidopyrimidine Glycosylase; C468610:DNA-formamidopyrimidine glycosylase, E coli; C068631:UvrA protein, E coli; D000251:Adenosine Triphosphatases