Lack of effect of ET antibody or SB 209670 on endotoxin-induced renal failure.
Elevated plasma levels of endothelin-1 (ET-1) in patients with septic shock have implicated ET-1 in the vascular hypoperfusion and organ dysfunction, including renal failure, that occur in this condition. Administration of endotoxin to rats induces renal dysfunction characterized by increased blood urea nitrogen (BUN) and plasma creatinine (Cr) levels. Here, we have found that neither SB 209670 (an ETA and ETB receptor antagonist) nor an affinity-purified ET antibody blocked the endotoxin-induced changes in renal function, suggesting that ET-1 is not involved in the pathophysiology of endotoxin-induced renal dysfunction.
Wellings
R P
RP
William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, England.
Corder
R
R
Vane
J R
JR
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000502:physiology*; D007189:Indans / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000517:prevention & control*; D012756:Sheep
D000906:Antibodies; D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D007189:Indans; D008070:Lipopolysaccharides; C087551:1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-