title: Factors affecting bone graft incorporation.
abstract: Successful graft incorporation requires that an appropriate match be made among the biologic activity of a bone graft, the condition of the perigraft environment, and the mechanical environment. The authors have studied, in a wide variety of animal models, the factors that affect the main components of bone graft incorporation: revascularization, new bone formation, and host-graft union. The principal determinant of the rate, pattern, and amount of revascularization is the presence or absence of a vascular pedicle. The nonvascularized bone graft is entirely dependent on the surrounding tissue for its revascularization, which results in a noticeable delay in vessel ingrowth. The principal determinant of the rate and amount of new bone formation on, in, or about a bone graft is the presence or absence of living, histocompatible, committed bone-forming cells. When living cells are not part of the graft at the time of implantation, the cells that form new bone are derived from host tissues, and new bone formation is delayed. The principal determinants of host-graft union are stability of the construct and contact between host bone and the graft. Factors that slow or inhibit all of these processes are reduction of the biologic activity of the graft by freezing or some other treatment, histocompatibility antigen disparities between donor and recipient, mechanical instability between the graft and the perigraft environment, and local and systemic interference with the biologic activity of the graft and surrounding tissue, for example, by irradiation or the administration of cisplatin. The task of the clinician who does a bone grafting procedure is to choose the right graft or combination of grafts for the biologic and mechanical environment into which the graft will be placed.
authors.affiliation: Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, 44106-5043, USA.
authors.forename: S
authors.initials: S
authors.lastname: Stevenson
authors.forename: S E
authors.initials: SE
authors.lastname: Emery
authors.forename: V M
authors.initials: VM
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism; D004285:Dogs; D011817:Rabbits; D051381:Rats