Physiological and histological recovery of the olfactory mucosa of the frog after a dichlobenil injection.
Four days after a single systemic injection of 50 mg/kg of dichlobenil (2,6-dichlorobenzonitrile), the olfactory neuroepithelium of the frog is extensively damaged. At the same time, electrophysiological responses to odorant stimulations (2-heptanone, D-limonene, amyl acetate, camphor) are largely reduced. Pretreatment of the animals with metyrapone, an inhibitor of cytochrome P-450 enzymatic systems, inhibits the histological and physiological toxic effects of the dichlobenil injection. The olfactory tissue recovered 3 months after the dichlobenil injections and responses to odorant stimulations returned. The same dichlobenil injections did not induce lesions in the vomeronasal neuroepithelium.
Delaleu
J C
JC
Laboratoire de Physiologie Neurosensorielle, CNRS URA 180, Université Claude Bernard, Villeurbanne, France.
Sicard
G
G
D000818:Animals; D001549:Benzamides / Q000633:toxicity*; D004594:Electrophysiology; D009336:Necrosis / Q000139:chemically induced; D009570:Nitriles; D009812:Odorants; D009831:Olfactory Mucosa / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D011895:Rana ridibunda / Q000033:anatomy & histology* / Q000502:physiology*; D013268:Stimulation, Chemical
D001549:Benzamides; D009570:Nitriles; C055869:dichlobanil