title: A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis.
abstract: A 51-year old woman who had type-C chronic hepatitis developed autoimmune hemolytic anemia after 4 weeks treatment with a total 48 million interferon-beta, 6 million 8 times. Indirect Coomb's test turned from negative to positive through IFN therapy and a complication of asymptomatic primary biliary cirrhosis was confirmed by histologic findings of the biopsied liver which was performed during IFN therapy and a presence of anti-mitochondrial antibody. After stopping IFN therapy and adding prednisolone anemia improved in getting negative indirect Coombs test but remaining positive direct Coombs test.
authors.affiliation: Department of Internal Medicine, Hanawa Kohsei Hospital, Fukushima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kazuta
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Sagawa
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Funabashi
authors.forename: T
authors.initials: T
authors.lastname: Moritoh
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D005260:Female; D006526:Hepatitis C / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D016899:Interferon-beta