Expression of melanocortin 1 receptor in periaqueductal gray matter.
The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative. In human PAG, the immunoreactivity for MC1 receptor was detected in scattered cells. These results indicate that a restricted distribution of MC1 receptor is present in the central nervous system.
Xia
Y
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Department of Pharmaceutical Biosciences, Uppsala University, Sweden.
Wikberg
J E
JE
Chhajlani
V
V
D000818:Animals; D001483:Base Sequence; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D010487:Periaqueductal Gray / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018043:Receptors, Corticotropin / Q000032:analysis*; D044101:Receptors, Melanocortin
D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin