title: Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs.
abstract: Continuing investigations of abdominal body wall reconstruction materials suggest that unacceptable implant complications continue and that the ideal material has not yet been found. This pilot study compared xenogeneic (porcine) small intestine submucosa (SIS) with polypropylene mesh (PPM) for repair of created partial-thickness (six dogs) and full-thickness (six dogs) abdominal wall defects. Postoperative clinical evaluation of all dogs showed no evidence of implant failure. Dogs were euthanized at 1, 2, and 4 months after surgery. The SIS implants were completely replaced by host tissue at 4 months as determined by immunohistochemistry. The resultant repair was well-organized, smooth, dense collagenous connective tissue that was well incorporated into the adjacent fascia and skeletal muscle fiber bundles. In the full-thickness defect dogs, omentum covered a significantly larger portion of PPM (P = 0.001) and was more firmly attached to PPM (P = 0.0001) compared to SIS/connective tissue repair. We conclude that xenogeneic SIS can be used as an abdominal body wall repair material in the dog and warrants further investigations.
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana 47907-1248, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Clarke
authors.forename: G C
authors.initials: GC
authors.lastname: Lantz
authors.forename: S K
authors.initials: SK
authors.lastname: Salisbury
authors.forename: S F
authors.initials: SF
authors.lastname: Badylak
authors.forename: M C
authors.initials: MC
authors.lastname: Hiles
authors.forename: S L
authors.initials: SL
authors.lastname: Voytik
mesh_terms: D000009:Abdominal Muscles / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001705:Bioprosthesis; D004285:Dogs; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D007421:Intestine, Small / Q000637:transplantation*; D008567:Membranes, Artificial; D010865:Pilot Projects; D011126:Polypropylenes; D011184:Postoperative Period; D019736:Prostheses and Implants; D013526:Surgical Mesh; D013552:Swine; D014183:Transplantation, Heterologous
chemical_list: D008567:Membranes, Artificial; D011126:Polypropylenes