Tolerability and kinetics of a solvent-detergent-treated intravenous immunoglobulin preparation in hypogammaglobulinaemia patients.
The tolerability and kinetics of a solvent-detergent-treated 6% intravenous immunoglobulin (IVIG) preparation were studied in 15 hypogammaglobulinaemia patients during 3-4 regular substitution infusions of 9-48 g, the mean dose being 359 mg/kg. The infusions were well tolerated, and the trough serum IgG levels achieved were comparable to two commercial IVIG preparations. The stepwise increase of the infusion rate up to 5 mg/kg/min and the use of this IVIG as a 12% solution were possible without serious adverse events in all the 6 studied hypogammaglobulinaemia patients. This greatly reduced the time needed for the infusions.
Ebeling
F
F
Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Baer
M
M
Hormila
P
P
Järventie
G
G
Koistinen
P
P
Kätkä
K
K
Oksanen
K
K
Perkkiö
M
M
Ruutu
T
T
Soppi
E
E
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000628:therapy*; D000368:Aged; D002648:Child; D003902:Detergents; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D012997:Solvents; D013997:Time Factors
D003902:Detergents; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D012997:Solvents