Endothelin-induced bronchoconstriction in perfused rat lungs is partly mediated by thromboxane.
In isolated rat lungs, perfusion with either endothelin-1 (ET-1) or the ETB receptor agonist IRL 1620 caused a slowly developing and long-lasting bronchoconstriction. This bronchoconstriction was partly attenuated by the thromboxane receptor antagonist BM 13177. Our data suggest that thromboxane partly mediates this process, together with further unknown mechanisms responsible for ET-induced bronchoconstriction.
Uhlig
S
S
Biochemical Pharmacology, University of Konstanz, Germany.
von Bethmann
A
A
D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D016232:Endothelins / Q000494:pharmacology*; D005260:Female; D010446:Peptide Fragments / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D017466:Receptors, Endothelin / Q000502:physiology; D013449:Sulfonamides / Q000494:pharmacology; D013931:Thromboxanes / Q000502:physiology*
D016232:Endothelins; D010446:Peptide Fragments; D017466:Receptors, Endothelin; D013449:Sulfonamides; D013931:Thromboxanes; C074308:sovateltide; C040624:sulotroban