Starting the cell cycle: what's the point?
Early work on regulation of the budding yeast cell cycle defined a critical regulatory step called 'Start', considered to represent cell cycle commitment. Recent work has defined the probable molecular basis of Start to be activation of Cln-Cdc28 protein kinase complexes. Cln-Cdc28 kinases may directly regulate many cell cycle processes, including some classically considered to be 'post-Start'. Specialization of function among the three genetically redundant CLN genes is becoming apparent.
Cross
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Rockefeller University, New York, USA. fcross@rockvax.rockefeller.edu
D002453:Cell Cycle / Q000502:physiology*; D013997:Time Factors; D015003:Yeasts / Q000166:cytology