title: [Brain metastasis. Palliative treatment with radiosurgery].
abstract: This is a retrospective review of 52 patients with metastatic brain disease who underwent stereotactic radiosurgery at McGill University in Montreal. The radiosurgical treatment was performed with the dynamic rotation technique in which there is continuous and simultaneous movement of treatment couch and machine gantry of a 10 MV linac. All patients were treated with a single isocenter and a median dose of 1800 cGy was delivered. In 88% of the cases radiosurgery was given after failure from whole brain conventional irradiation. All 52 cases were assessed with brain CT post radiosurgery. The median follow up time was 6 months (range 1-37 months) and the response rate (partial or complete) was 64%. Only 4 patients (7%) developed late complications related to the treatment. These findings are similar to the literature. Stereotactic radiosurgery is a well tolerated, effective and minimally invasive treatment technique which has a high response rate in selected patients with small, well delineated metastatic brain lesion. Its definitive value as a single therapy or combined with whole brain conventional radiotherapy is being studied in prospective and randomized trials.
authors.affiliation: Departamento de Oncologia (Divisão de Radioterapia, McGill University, Montreal, Canada.
authors.forename: S L
authors.initials: SL
authors.lastname: Faria
authors.forename: L
authors.initials: L
authors.lastname: Souhami
authors.forename: J P
authors.initials: JP
authors.lastname: Bahary
authors.forename: J L
authors.initials: JL
authors.lastname: Caron
authors.forename: J G
authors.initials: JG
authors.lastname: Villemure
authors.forename: A
authors.initials: A
authors.lastname: Olivier
authors.forename: B
authors.initials: B
authors.lastname: Clark
authors.forename: E B
authors.initials: EB
authors.lastname: Podgorsak
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010166:Palliative Care; D011379:Prognosis; D016634:Radiosurgery / Q000009:adverse effects; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed