Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless.
Diffusible factors of several protein families control appendage outgrowth and patterning in both insects and vertebrates. In Drosophila wing development, the gene decapentaplegic (dpp) is expressed along the anteroposterior compartment boundary. Early wingless (wg) expression is involved in setting up the dorsoventral boundary. Interaction between dpp- and wg-expressing cells promotes appendage outgrowth. Here, it is shown that optomotor-blind (omb) expression is required for distal wing development and is controlled by both dpp and wg. Ectopic omb expression can lead to the growth of additional wings. Thus, omb is essential for wing development and is controlled by two signaling pathways.
Grimm
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Theodor-Boveri-Institut (Biozentrum), Lehrstuhl für Genetik, Universität Würzburg, Germany.
Pflugfelder
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GO
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D007301:Insect Hormones / Q000235:genetics* / Q000502:physiology; D007814:Larva / Q000235:genetics / Q000254:growth & development; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D020825:T-Box Domain Proteins; D014921:Wings, Animal / Q000254:growth & development*; D051155:Wnt1 Protein
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D007301:Insect Hormones; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D020825:T-Box Domain Proteins; D051155:Wnt1 Protein; C064196:dpp protein, Drosophila; C074622:wg protein, Drosophila; C072962:bi protein, Drosophila