Effects of amphetamine on cell mediated immune response in mice.
Mice injected with amphetamine showed a dose-related suppression of the natural killer cell activity. The capacity of T-cells to generate cytotoxic T-lymphocytes (CTL) in mixed lymphocyte cultures and in vivo was also assayed and amphetamine was found to inhibit CTL responses.
Núñez-Iglesias
M J
MJ
Department of Pharmacology, University of Santiago de Compostela, Spain.
Castro-Bolaño
C
C
Losada
C
C
Pereiro-Raposo
M D
MD
Riveiro
P
P
Sánchez-Sebio
P
P
Mayán-Santos
J M
JM
Rey-Méndez
M
M
Freire-Garabal
M
M
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007111:Immunity, Cellular / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology
D000661:Amphetamine