Absorption and excretion of iodixanol after intragastric administration to rats.
Absorption and excretion of iodixanol 320 mg I/ml were investigated in rats after intragastric administration of 2.5 g I/kg b.w. Animals were observed for up to 96 hours after treatment, and blood, urine and feces taken at several time-points throughout the experiment. Concentrations of iodixanol in serum and urine were measured by means of reversed-phase high-performance liquid chromatography. Fecal concentrations of iodixanol, based on iodine measurements, were determined by X-ray fluorescence spectrometry. Serial radiographs were obtained and histopathological examination was performed on selected tissues. The results indicate that less than 1% of the intragastric dose of iodixanol is absorbed from the intestine into the blood stream. No adverse clinical signs were observed, and there were no treatment-related histomorphological findings.
Dunkel
J A
JA
Research & Development, Nycomed Imaging AS, Oslo, Norway.
Helund
I F
IF
Jacobsen
P B
PB
Grant
D
D
Walday
P
P
Refsum
H
H
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol