[Mechanisms of mobilization of intracellular stored calcium].
The release of intracellular stored Ca2+ is mainly regulated by an inositol 1,4,5-triphosphate (IP3) receptor system and a ryanodine receptor system. The former induces Ca2+ release directly when the receptors are bound to IP3. The later may function through the Ca2+ induced Ca2+ release mechanism when the ryanodine receptors are activated. Cyclic ADP ribose, a metabolite of NAD+ which is regulated by complicated mechanisms, is one of the most important factors causing activation of ryanodine receptors. The two systems may interact with each other to regulate Ca2+ release from intracellular calcium pool.
Li
H W
HW
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, Beijing.
Wang
X
X
Han
Q D
QD
D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives / Q000502:physiology; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D036563:Cyclic ADP-Ribose; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D009124:Muscle Proteins / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D009124:Muscle Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D019837:Ryanodine Receptor Calcium Release Channel; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium