title: A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans.
abstract: Twelve normolipidic healthy human subjects were fed a diet with or without additional soybean phytosterols for 4 weeks in a crossover design. The order of the treatments was randomized. Phytosterols were added to the diet blended in butter. The dietary ratio cholesterol:phytosterols was 0.7 during the control period (436 mg cholesterol/day and 29 mg phytosterols/day) and 1.88 during the phytosterols period (410 mg cholesterol/day and 740 mg phytosterols/day). Blood cholesterol was 10% lower after subjects consumed the phytosterol-enriched diet than when they consumed the control diet (p < 0.001), which was due to a 15% LDL cholesterol decrease (p < 0.001). The HDL cholesterol:LDL cholesterol ratio was markedly enhanced (+25%) (p < 0.01). These findings suggest that a significant lowering of plasma total and LDL cholesterol can be effected by a modest dietary intake of soybean phytosterols.
authors.affiliation: Centre de Nutrition Humaine, Nancy, France.
authors.forename: X
authors.initials: X
authors.lastname: Pelletier
authors.forename: S
authors.initials: S
authors.lastname: Belbraouet
authors.forename: D
authors.initials: D
authors.lastname: Mirabel
authors.forename: F
authors.initials: F
authors.lastname: Mordret
authors.forename: J L
authors.initials: JL
authors.lastname: Perrin
authors.forename: X
authors.initials: X
authors.lastname: Pages
authors.forename: G
authors.initials: G
authors.lastname: Debry
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D006801:Humans; D008297:Male; D010840:Phytosterols / Q000008:administration & dosage*; D013025:Glycine max
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010840:Phytosterols; D002784:Cholesterol