Towards the development of ryanoid insecticides with low mammalian toxicity.
The effects of ryanodine and 9,21-didehydroryanodol on mammalian and insect muscles have been compared. Whereas ryanodine markedly affected the functioning of insect and mammalian muscles, the action of 9,21-didehydroryanodol was mainly restricted to the insect muscles. Unlike ryanodine, 9,21-didehydroryanodol did not elicit a contracture from insect muscles, yet it inhibited muscle contractions. This inhibition is associated with changes in the ion selectivities of potassium channels located in the muscle plasma membrane. These changes lead to a decline in muscle resting potential and loss of excitability.
Usherwood
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PN
Department of Life Science, University of Nottingham, UK. plzpnru@pln1.Nott.ac.UK
Vais
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D000818:Animals; D007306:Insecticides / Q000633:toxicity*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects; D011817:Rabbits; D012433:Ryanodine / Q000633:toxicity*
D007306:Insecticides; D015221:Potassium Channels; D012433:Ryanodine