Influence of deoxyspergualin on mononuclear phagocytic system in mice.
The influence of deoxyspergualin (DSG) on mononuclear phagocytic system was examined in BALB/c mice. DSG did not influence on both the organ distribution of sheep red blood cells (SRBC) and blood clearance of colloidal carbon when the agent was administered intraperitoneally into mice at doses of 5.0 and 10.0 mg/kg for six consecutive days before antigen. Hemagglutination titers in experimental and control mice did not differ significantly when 10.0 mg/kg of DSG was given six times before SRBC injection. However, when administered during the course of the response (days 0 to 5) DSG (5.0 mg/kg/day) markedly suppressed antibody formation.
Asano
K
K
Department of Medical Biology, School of Medicine, Showa University, Tokyo, Japan.
Muramatsu
K
K
Okamoto
K
K
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens / Q000276:immunology; D002860:Chromium Radioisotopes; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006384:Hemagglutination; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010586:Phagocytes / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects*
D000941:Antigens; D002860:Chromium Radioisotopes; D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus