title: Noninvasive quantification of rCBF using positron emission tomography.
abstract: This study proposes a new method for the pixel-by-pixel quantification of regional CBF (rCBF) with positron emission tomography and H(15)(2)O by using a reference tissue region. No arterial blood is required. Simulation studies revealed that the calculation of rCBF was fairly stable provided that the frame time was relatively short compared with total scan time. In practice, calculated CBF images correlated significantly with those obtained with the dynamic/integral method. Because the method accurately detects changes in CBF, it is particularly suitable for brain activation studies.
authors.affiliation: Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watabe
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: V
authors.initials: V
authors.lastname: Cunningham
authors.forename: A A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: P
authors.initials: P
authors.lastname: Bloomfield
authors.forename: M
authors.initials: M
authors.lastname: Mejia
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: A K
authors.initials: AK
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D006801:Humans; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000379:methods*