title: Glucose and oxygen metabolism in the fetal foal during late gestation.
abstract: With the use of [U-14C]glucose tracer methodology, the rates of umbilical uptake, utilization, oxidation, and production of glucose were determined in nine chronically catheterized fetal foals in the fed state between 268 and 325 days of gestation (term approximately 335 days). At the same time, the rates of umbilical O2 and lactate uptake were measured in all nine fetuses by Fick principle. The mean fetal rates of umbilical glucose uptake, glucose utilization, and CO2 production from glucose carbon were 36.9 +/- 2.5, 36.4 +/- 1.7, and 117.7 +/- 17.4 mumol.min-1.kg fetal body wt-1, respectively (n = 9). Endogenous glucose production was therefore negligible in the fetal foal in the fed state. Production of CO2 from glucose carbon accounted for 40.9 +/- 6.5% of the umbilical O2 uptake, which averaged 292 +/- 15 mumol.min-1.kg-1 (n = 9). No significant changes in fetal glucose or O2 metabolism were observed with increasing gestational age. The rates of umbilical glucose uptake, glucose utilization, and CO2 production from glucose carbon (P < 0.01), but not the rate of umbilical O2 uptake (P > 0.05), were positively correlated with the fetal blood glucose level. There was a significant umbilical lactate uptake in the fetuses older than 290 days (12.3 +/- 4.1 mumol.min-1.kg-1, n = 5, P < 0.05) but not in the younger animals (6.2 +/- 9.6 mumol.min-1.kg-1, n = 4, P > 0.05). Hence, glucose is used for both oxidative and nonoxidative metabolism in utero and is a major, although not the sole, oxidative substrate in the fetal foal during late gestation.
authors.affiliation: Physiological Laboratory, Cambridge, United Kingdom.
authors.forename: A L
authors.initials: AL
authors.lastname: Fowden
authors.forename: M
authors.initials: M
authors.lastname: Silver
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005314:Embryonic and Fetal Development; D005260:Female; D005312:Fetal Blood; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D005947:Glucose / Q000378:metabolism*; D006736:Horses; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010101:Oxygen Consumption; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D007773:Lactates; D019344:Lactic Acid; D005947:Glucose