Bioactive saponins and glycosides. I. Senegae radix. (1): E-senegasaponins a and b and Z-senegasaponins a and b, their inhibitory effect on alcohol absorption and hypoglycemic activity.
E-Senegasaponins a, b, and c were isolated from Senegae Radix, the root of Polygala senega L. var. latifolia TORREY et GRAY, together with their Z-isomers of the 4"-methoxycinnamoyl moiety, Z-senegasaponins a, b, and c. The structures of E-senegasaponins a and b and Z-senegasaponins a and b have been elucidated on the basis of chemical and physicochemical evidence, and the geometrical isomeric structure of the 4"-methoxycinnamoyl group in each saponin was found to show tautomer-like behavior in methanol solution or under irradiation with fluorescent lamps. E and Z-Senegasaponins a and b were found to exhibit potent inhibitory effects on alcohol absorption and hypoglycemic activity in the oral D-glucose tolerance tests in rats, and some structure-activity relationships of the acylated bisdesmoside-type saponins were clarified.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Murakami
T
T
Ueno
T
T
Kadoya
M
M
Matsuda
H
H
Yamahara
J
J
Murakami
N
N
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000431:Ethanol / Q000493:pharmacokinetics*; D007004:Hypoglycemic Agents / Q000037:antagonists & inhibitors*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D012503:Saponins; C098154:senegasaponin a; C098155:senegasaponin b; D000431:Ethanol; D009828:Oleanolic Acid