title: Intracerebral A lambda amyloidoma diagnosed by stereotactic biopsy.
abstract: In a 70-year-old patient with an intracerebral tumor, the very rare diagnosis of an A lambda amyloidoma has been made by stereotactic biopsy using immunohistochemistry with a panel of antibodies directed against amyloid fibril proteins of various origins. The production by an apparent benign monoclonal plasma cell proliferation with secretion of paraproteins into the cerebrospinal fluid is assumed. It is the 4th case in which the amyloid protein was classified as derived from immunoglobulin lambda-light chains and, to our knowledge the first in which an A lambda amyloidoma has been diagnosed intra vitam. The amyloid is restricted to the brain and no systemic involvement has been detected. Therapeutic procedures are discussed.
authors.affiliation: Institute for Pathology, University of Cologne, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schröder
authors.forename: R P
authors.initials: RP
authors.lastname: Linke
authors.forename: J
authors.initials: J
authors.lastname: Voges
authors.forename: W
authors.initials: W
authors.lastname: Heindel
authors.forename: V
authors.initials: V
authors.lastname: Sturm
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000473:pathology*; D001706:Biopsy; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D013238:Stereotaxic Techniques
chemical_list: D007146:Immunoglobulin lambda-Chains