title: Occurrence of pneumococci with resistance or decreased susceptibility to penicillin in southeast Sweden.
abstract: The minimal inhibitory concentrations (MICs) of 14 beta-lactam and non-beta-lactam antibiotics were determined for all pneumococci with intermediate susceptibility (I), (n = 26) or resistance (R), (n = 15) to penicillin G isolated at the Clinical Microbiology Laboratory, University Hospital, Linköping, Sweden during 1994. These isolates accounted for 3% of all pneumococcal isolates. The results were compared with those of 26 penicillin-susceptible isolates. The MICs of all tested beta-lactam antibiotics increased with MICs of penicillin G. The least increase and the lowest MICs of these agents were recorded for cefotaxime and imipenem. 27% of I- and R-strains were multiple-resistant, most often to tetracycline, trimethoprim-sulfametoxazole, erythromycin, chloramphenicol and clindamycin. All strains were susceptible to vancomycin and rifampicin. I-strains belonged to at least 5 different serotypes. However, 12 of the 15 R-strains were serotype 9 and 6 of these were recovered during contact tracing, indicating spread of a single clone within day-care centres.
authors.affiliation: Department of Clinical Microbiology, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Kihlström
authors.forename: B
authors.initials: B
authors.lastname: Normann
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D016358:Contact Tracing; D018432:Drug Resistance, Multiple; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D013548:Sweden / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D010400:Penicillin G