PCR-SSCP-HDX analysis of pooled DNA for more rapid detection of germline mutations in large genes. The BRCA1 example.
Kozłowski
P
P
Laboratory of Cancer Genetics, Polish Academy of Sciences, Poland.
Sobczak
K
K
Napierała
M
M
Woźniak
M
M
Czarny
J
J
Włodzimierz
J
J
Kryzosiak
J
J
D019313:BRCA1 Protein; D001483:Base Sequence; D004252:DNA Mutational Analysis / Q000379:methods*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D009692:Nucleic Acid Heteroduplexes / Q000235:genetics; D009857:Oncogenes; D016133:Polymerase Chain Reaction / Q000379:methods; D018807:Polymorphism, Single-Stranded Conformational; D014157:Transcription Factors / Q000235:genetics*
D019313:BRCA1 Protein; D017931:DNA Primers; D009363:Neoplasm Proteins; D009692:Nucleic Acid Heteroduplexes; D014157:Transcription Factors