title: Isochromosome 7q in adult Wilms' tumor.
abstract: We describe cytogenetic and histologic findings in a Wilms' tumor resected from a 37-year-old man. The tumor karyotype was 45,X,-Y,i(7)(q10). These findings are notable because overrepresentation of chromosome 7 long arm material, i(7)(q10) in particular, has been described recently as a nonrandom event in pediatric Wilms' tumors. The present case suggests a shared genetic pathway in the initiation or progression of some pediatric and adult Wilms' tumors.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Fletcher
authors.forename: A A
authors.initials: AA
authors.lastname: Renshaw
mesh_terms: D000328:Adult; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D008297:Male; D009396:Wilms Tumor / Q000235:genetics* / Q000648:ultrastructure