Xenotransplantation and high tumorigenicity of feline tumors in SCID mice.
Nine feline tumors resected at surgery were subcutaneously xenotransplanted into SCID mice. The primary take rate of the benign and malignant tumors was 50% (1/2) and 100% (7/7) respectively. Six of the eight primary tumor xenografts transplanted and grown in the first recipient were successfully transplanted serially. One feline mammary adenocarcinoma xenograft metastasized to the lung of a SCID mouse. The primary take rate of feline tumors to SCID mice was high and the established xenografts appear to be valuable tools for investigating growth and metastasis mechanisms, and various therapies for feline neoplasms.
Maruo
K
K
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
Sugimoto
T
T
Suzuki
K
K
Shirota
K
K
Ejima
H
H
Nomura
T
T
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004195:Disease Models, Animal; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D013047:Specific Pathogen-Free Organisms; D014183:Transplantation, Heterologous