Mutations in tumour suppressor gene p53 in two feline fibrosarcomas.
Exons 5-7 of the tumour suppressor gene p53 were investigated in genomic DNA of tumours of domestic cats. In one fibrosarcoma investigated we observed a mutation GAG-->AAG (glutamic acid-->lysine) in codon 180; in another there was a mutation CGG-->TGG (arginine-->tryptophane) in codon 248.
Mayr
B
B
Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.
Schaffner
G
G
Kurzbauer
R
R
Schneider
A
A
Reifinger
M
M
Loupal
G
G
D000818:Animals; D001483:Base Sequence; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D005354:Fibrosarcoma / Q000235:genetics / Q000662:veterinary*; D016158:Genes, p53 / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation / Q000235:genetics*