Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M.
Five cytokines activate the gp130 IL-6 transducer: ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor and oncostatin M. Human plasmacytoma cell lines, completely dependent on the addition of one of these five cytokines for their growth, were used to obtain anti-gp130 monoclonal antibodies specifically inhibiting one of these five cytokines without affecting the biological activity of the others. These antibodies should improve our understanding of the interaction of gp130 transducer using cytokines with gp130 transducer and facilitate the design of new cytokine inhibitors.
Gu
Z J
ZJ
Institute for Molecular Genetics, CNRS, Montpellier, France.
Wijdenes
J
J
Zhang
X G
XG
Hallet
M M
MM
Clement
C
C
Klein
B
B
D000911:Antibodies, Monoclonal / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology* / Q000494:pharmacology; D001483:Base Sequence; D020934:Ciliary Neurotrophic Factor; D050822:Cytokine Receptor gp130; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D017370:Interleukin-11 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000494:pharmacology; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D053683:Oncostatin M; D010455:Peptides / Q000378:metabolism*; D011994:Recombinant Proteins; D015398:Signal Transduction
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D020934:Ciliary Neurotrophic Factor; D017931:DNA Primers; C494199:IL6ST protein, human; D017370:Interleukin-11; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C508351:OSM protein, human; D010455:Peptides; D011994:Recombinant Proteins; D053683:Oncostatin M; D050822:Cytokine Receptor gp130