title: MtDNA-encoded histocompatibility antigens.
abstract: Mitochondrially encoded H antigens are by-products of a system that has evolved in vertebrates to present peptides from intracellular pathogens on the cell surface for detection by CTLs, which can lyse the infected cell. CTL lines and clones with defined specificity against mitochondrial H antigens, which can be maintained in culture for long periods, offer a unique tool in mitochondrial genetics. Expression of polymorphic mitochondrial H antigens depends on both the presence and the activity of the corresponding mitochondrial genome, and CTLs can provide strong selection against cells displaying their cognate antigen.
authors.affiliation: Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas 75235, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Dabhi
authors.forename: K F
authors.initials: KF
authors.lastname: Lindahl
mesh_terms: D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002860:Chromium Radioisotopes; D002999:Clone Cells; D046508:Culture Techniques / Q000379:methods; D004272:DNA, Mitochondrial / Q000235:genetics*; D015870:Gene Expression; D014644:Genetic Variation; D006680:HLA Antigens / Q000096:biosynthesis / Q000235:genetics; D006649:Histocompatibility Antigens / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000276:immunology*; D011110:Polymorphism, Genetic; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014019:Tissue Donors; D014181:Transplantation Immunology; D014714:Vertebrates
chemical_list: D002860:Chromium Radioisotopes; D004272:DNA, Mitochondrial; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007376:Interleukin-2