Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice.
Chlorpromazine- and haloperidol-induced hypothermia were examined in mice. The alpha 1 receptor agonist phenylephrine partially antagonized the hypothermia, while the dopamine D2 receptor agonist apomorphine did not inhibit it. The central serotonin2 (5-HT2) receptor agonist I-2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) strongly inhibited the chlorpromazine- and haloperidol-induced hypothermia. Both drugs at doses which can elicit hypothermia antagonized head twitch responses mediated by the central 5-HT2 receptor. These results suggest that the chlorpromazine- and haloperidol-induced hypothermia may be mediated by the blockade of the central 5-HT2 receptor.
Yamada
J
J
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Sugimoto
Y
Y
Horisaka
K
K
D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002746:Chlorpromazine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D006220:Haloperidol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007036:Hypothermia, Induced; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010656:Phenylephrine / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000819:agonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D000662:Amphetamines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D017366:Serotonin Receptor Agonists; D010656:Phenylephrine; D006220:Haloperidol; D001058:Apomorphine; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine; D002746:Chlorpromazine