title: Phase II study of mitomycin, ifosfamide and cisplatin in adenocarcinoma of the oesophagus.
abstract: We evaluated the effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus. Two courses of mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2;MIC) were given followed by evaluation of response by barium swallow and computed tomography scan. Of 20 patients, 17 completed both courses and 4 (20%) showed a partial response. Toxicity was generally mild and consisted principally of nausea and vomiting. Altogether, 15 patients were surgically explored; resection was completed in 12 patients, 3 of whom died in hospital (25%). Neoadjuvant therapy with MIC offers no advantage over surgery alone.
authors.affiliation: Regional Department of Thoracic Surgery and Oesophageal Research Laboratory, Birmingham Heartlands Hospital, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Allen
authors.forename: J P
authors.initials: JP
authors.lastname: Duffy
authors.forename: S J
authors.initials: SJ
authors.lastname: Darnton
authors.forename: M H
authors.initials: MH
authors.lastname: Cullen
authors.forename: H R
authors.initials: HR
authors.lastname: Matthews
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D008937:Mitomycins / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D002945:Cisplatin; D007069:Ifosfamide