title: Learning impairment in 1-2-day-old epileptic chicks.
abstract: The cause of learning impairment in children with seizure disorders is obscure, in part because of the lack of adequate animal models of learning deficiencies that can be used for study. The discriminating passive avoidance test has been used extensively to study learning behavior in chicks. In the present study, we applied the passive avoidance test to epileptic chicks to determine if learning deficiencies could be demonstrated in this epileptic model. Epileptic fowl have a hereditary form of primary generalized epilepsy characterized by tonic-clonic seizures. The seizures occur spontaneously and can also be induced by photic stimulation. The epileptic phenotype is the result of an autosomal recessive mutation. Heterozygotes do not have seizures and were used as age-matched controls. The discriminating passive avoidance test used in the present study was based on the observation that chicks readily peck at bright shiny beads. Once chicks taste a colored bead coated with a bitter chemical (methylanthranilate), they refuse to peck the bead on subsequent presentations. In addition, chicks can discriminate between colored beads and will continue to peck at a bead of different color than the methylanthranilate (MeA)-coated bead. compared to carriers, epileptic chicks demonstrated significantly less ability to discriminate between colored beads. Furthermore, this learning impairment was observed in epileptic chicks treated with phenobarbital (PB), indicating that the learning impairment in epileptic chicks is an inherent neurological problem and not a consequence of seizure activity.
authors.affiliation: Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada.
authors.forename: D D
authors.initials: DD
authors.lastname: Gervais-Fagnou
authors.forename: J M
authors.initials: JM
authors.lastname: Tuchek
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002645:Chickens / Q000235:genetics*; D004193:Discrimination Learning / Q000187:drug effects; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D007859:Learning Disabilities / Q000235:genetics*; D008297:Male; D008568:Memory / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010634:Phenobarbital