title: Nondysplastic fetal renal hypoplasia associated with severe oligohydramnios: clinical, pathologic, and morphometric findings.
abstract: Two fetuses with severe bilateral renal hypoplasia are described; both diagnoses were made following elective abortion for oligohydramnios and suspected renal dysplasia. A 20-week female fetus (46,XX) had pulmonary hypoplasia and very small kidneys (7% of expected weight) that were normally shaped and nondysplastic, with well-formed medullae and metanephric blastema and markedly diminished cortices with only rare glomeruli. A 23-week male fetus (46,XY) had small kidneys (13% of expected weight) that were nondysplastic, normally shaped, and histologically well organized with moderately decreased numbers of glomeruli. Isolated bilateral renal hypoplasia has not previously been well characterized in fetuses; the presence of oligohydramnios (both cases) and pulmonary hypoplasia (one case) suggests that this finding is associated with impaired fetal renal function and may adversely influence neonatal survival.
authors.affiliation: Department of Pathology, Children's Hospital Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: T
authors.initials: T
authors.lastname: Boyd
authors.forename: S
authors.initials: S
authors.lastname: Rosen
authors.forename: R W
authors.initials: RW
authors.lastname: Redline
authors.forename: D R
authors.initials: DR
authors.lastname: Genest
mesh_terms: D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000002:abnormalities* / Q000473:pathology*; D008297:Male; D016104:Oligohydramnios / Q000150:complications / Q000473:pathology*