[The effect of chromium picolinate on the liver levels of trace elements].
Chromium picolinate has been implicated as a lipid and carbohydrate reducing agent, and therefore it may be a valuable adjunct to the treatment and prevention of diabetes and heart disease. This compound is inexpensive and apparently nontoxic. In this work, we have determined the influence of its administration (100, 200, 500 micrograms Cr/ml, for 7 and 21 days) on hepatic content of Zn, Mn, Cu and Fe of male Wistar rats. The results show a variation of the levels of these elements after the administration of chromium picolinate, although the differences are only significantly (p < 0.01) in the case of Mn. This influence is dose-dependent, occurring a decrease of 72% in the group treated with 500 micrograms/ml (Pic-500) respect to the content of control group.
Aguilar
M V
MV
Departamento de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Alcalá de Henares, España.
Jorge
A M
AM
Mateos
C J
CJ
García
J
J
Laborda
J M
JM
Meseguer
I
I
Martínez-Para
M C
MC
González
M J
MJ
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007502:Iron Chelating Agents / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism*
D007502:Iron Chelating Agents; D010848:Picolinic Acids; D014131:Trace Elements; C030614:picolinic acid