Protein synthesis in cadmium- and pentachlorophenol-tolerant Euglena gracilis.
This work is a preliminary characterization of two adapted Euglena gracilis cell lines, one to cadmium and the other to pentachlorophenol. Growth curve analyses indicate that tolerance to one pollutant did not protect against the second pollutant. These suggest that metabolic pathways that are induced by one pollutant are specific for this pollutant. This specificity is detectable at the level of gene expression.
Barque
J P
JP
Laboratoire de Métabolisme Cellulaire et Xénobiotiques, Faculté de Pharmacie, Chatenay-Malabry Cedex, France.
Abahamid
A
A
Bourezgui
Y
Y
Chacun
H
H
Bonaly
J
J
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000494:pharmacology*; D005056:Euglena gracilis / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D015870:Gene Expression; D010416:Pentachlorophenol / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics
D004785:Environmental Pollutants; D011506:Proteins; D002104:Cadmium; D010416:Pentachlorophenol