T lymphocyte chemotaxis and skin diseases.
Recent advances in our understanding of the mechanisms of T lymphocyte motility and chemotaxis, particularly in aspects of lymphocyte-endothelial adhesion, transendothelial cell migration, and T-lymphocyte response to chemotactic gradients have contributed to our knowledge of how T lymphocytes accumulate during the initiation, the development and the control of inflammatory skin responses. In this review, we will summarize the present situation of studies on T lymphocyte adhesion and chemotaxis. The 3 major steps in T lymphocyte chemotaxis, e.g., recognition of extracellular chemotactic gradients, transduction into appropriate intracellular signals, and generation of motion, will be outlined. Skin-homing T lymphocytes, chemokines and other chemoattractants will also be discussed in relation to skin diseases.
Tan
J
J
Department of Dermatology, Marselisborg Hospital, Aarhus University, Denmark.
Thestrup-Pedersen
K
K
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D016207:Cytokines / Q000502:physiology; D006801:Humans; D012871:Skin Diseases / Q000473:pathology* / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000502:physiology*
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines