title: Effects of acetazolamide on the sleep apnea syndrome and its therapeutic mechanism.
abstract: Twenty male patients with sleep apnea syndrome were treated with acetazolamide (AZM), a carbonic anhydrase inhibitor. In 14 of the patient a significant decrease was found in the number of apnea, apnea index and % apnea time (percentage of time spent with apnea to the total sleep time) with improvement in sleep structure, clinical symptoms, such as insomnia, daytime excessive sleepiness and snoring. A significant decrease was also observed in arterial blood pH and HCO-3 in the 14 improved patients. On the other hand, no improvement occurred in the parameters of sleep apnea and sleep with AZM in the remaining six patients. Moreover, metabolic acidosis and an improvement in arterial blood gases did not occur with AZM in the six patients.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Kurume University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hashizume
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: H
authors.initials: H
authors.lastname: Mizuma
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Mukai
authors.forename: T
authors.initials: T
authors.lastname: Kotorii
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D000138:Acidosis / Q000378:metabolism; D000328:Adult; D000368:Aged; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000209:etiology; D012890:Sleep / Q000187:drug effects*; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000188:drug therapy*; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide