title: Sodwanones G, H, and I, new cytotoxic triterpenes from a marine sponge.
abstract: Three cytotoxic triterpenes, sodwanones G [5], H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC50 values between 20 and 0.02 microM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).
authors.affiliation: School of Chemistry, Tel-Aviv University, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Rudi
authors.forename: I
authors.initials: I
authors.lastname: Goldberg
authors.forename: Z
authors.initials: Z
authors.lastname: Stein
authors.forename: Y
authors.initials: Y
authors.lastname: Kashman
authors.forename: Y
authors.initials: Y
authors.lastname: Benayahu
authors.forename: M
authors.initials: M
authors.lastname: Schleyer
authors.forename: M D
authors.initials: MD
authors.lastname: Garcia Gravalos
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; C098374:sodwanone G; C098375:sodwanone H; C098376:sodwanone I