Structure and effects of a kinin potentiating fraction F (AppF) isolated from Agkistrodon piscivorus piscivorus venom.
The contractile action of bradykinin on isolated smooth muscles is known to be potentiated by special peptides isolated from snake venoms and other animal sources. A fraction F (AppF) has been derived from Agkistrodon piscivorus piscivorus venom. This fraction does not increase the depressor effect of bradykinin n blood pressure, potentiates the action of bradykinin on isolated guinea-pig ileum and prolongs the duration of relaxation in isolated rat duodenum. This fraction was able to inhibit the conversion of angiotensin I to angiotensin II in vitro. The primary structure of this decapeptide is given.
Ferreira
L A
LA
Departamento de Bioquimica e Biofisica, Instituto Butantan, São Paulo, Brazil.
Möllring
T
T
Lebrun
F L
FL
Raida
M
M
Znottka
R
R
Habermehl
G G
GG
D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000378:metabolism / Q000494:pharmacology; D003435:Crotalid Venoms / Q000737:chemistry*; D004357:Drug Synergism; D006168:Guinea Pigs; D013058:Mass Spectrometry; D009130:Muscle, Smooth / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D000806:Angiotensin-Converting Enzyme Inhibitors; D003435:Crotalid Venoms; D009842:Oligopeptides; D010446:Peptide Fragments; C006791:bradykinin potentiating factors; D000804:Angiotensin II; D000803:Angiotensin I; D001920:Bradykinin