[New functional properties of albumin].
Effects of albumin on N-demethylation reactions of substrates in rat liver microsomes were studied in vitro. Albumin was found both to accelerate and to inhibit the reaction of demethylation. The interaction between ligand and albumin appears to be responsible for these effects. The role of the effect in the metabolism of either xenobiotics or endogenous substances is discussed.
Pentiuk
A A
AA
Musin
R A
RA
Marchenko
G P
GP
D000418:Albumins / Q000378:metabolism*; D000818:Animals; D005557:Formaldehyde / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D008745:Methylation; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000418:Albumins; D008024:Ligands; D005557:Formaldehyde