Diabetes mellitus associated with pancreatic endocrine insufficiency in a kitten.
Diabetes mellitus, characterised by persistent hyperglycaemia and glucosuria, was diagnosed in a six-week-old kitten. Pancreatic sections contained low numbers of atypically small islets and immunohistochemistry demonstrated pancreatic endocrine insufficiency with virtually no production of any islet hormones. There was no inflammatory infiltration of the islets, as seen in the form of diabetes mellitus characteristic of juvenile humans.
Root
M V
MV
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Johnson
K H
KH
Allen
W T
WT
Johnston
S D
SD
D000682:Amyloid / Q000032:analysis / Q000378:metabolism; D000818:Animals; D001706:Biopsy / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D002371:Cat Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002415:Cats; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications / Q000151:congenital / Q000662:veterinary*; D005934:Glucagon / Q000032:analysis / Q000378:metabolism; D007074:Immunoglobulin G / Q000032:analysis / Q000378:metabolism; D007075:Immunoglobulin M / Q000032:analysis / Q000378:metabolism; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis / Q000097:blood / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000737:chemistry / Q000473:pathology* / Q000503:physiopathology*; D010179:Pancreas / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis / Q000378:metabolism
D000682:Amyloid; D001786:Blood Glucose; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D013004:Somatostatin; D005934:Glucagon