Successful treatment of vitiligo with a sex steroid-thyroid hormone mixture.
Four patients with generalized vitiligo were successfully treated by oral administration of a sex steroid-thyroid hormone (Metharmon-F, 2 tablets daily). Histopathologically, the repigmented skin showed increased numbers of melanocytes and melanin granules in the keratinocytes.
Muto
M
M
Department of Dermatology, Yamaguchi University School of Medicine, Ube, Japan.
Furumoto
H
H
Ohmura
A
A
Asagami
C
C
D000284:Administration, Oral; D000368:Aged; D015114:Androstenediol / Q000008:administration & dosage / Q000627:therapeutic use*; D000735:Androstenedione / Q000008:administration & dosage / Q000627:therapeutic use*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004970:Estrone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D008543:Melanins; D008544:Melanocytes / Q000187:drug effects / Q000473:pathology; D008875:Middle Aged; D011284:Pregnenolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012880:Skin Pigmentation / Q000187:drug effects; D013607:Tablets; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D013962:Thyroid (USP) / Q000008:administration & dosage / Q000627:therapeutic use*; D014820:Vitiligo / Q000188:drug therapy* / Q000473:pathology
D003879:Dermatologic Agents; D004338:Drug Combinations; D008543:Melanins; D013607:Tablets; D013962:Thyroid (USP); D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D011284:Pregnenolone; C039452:Metharmon F; D015114:Androstenediol