Strategies for the synthesis of some complex antitumor alkaloids.
The total synthesis of sesbanimide A and its analogues has been achieved. The synthesized sesbanimides have been investigated for structure activity relationship. An approach has been developed for the synthesis of the antitumour alkaloid manzamine A. Recent results in these areas will be discussed.
Pandit
U K
UK
Organic Chemistry Laboratory, University of Amsterdam, The Netherlands.
D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic