Platelet alloantigens HPA-1, -2, -3, -5 and -6b in Finns.
The human platelet alloantigens HPA-1, -2, -3, -5 and -6b in the Finnish population were determined using allele specific restriction analysis (PCR-ASRA) for HPA-1, -2, -3 and -5 and monoclonal antibody immobilized platelet antigen (MAIPA) assay for HPA-1, -3a, -5b and -6b. No discrepancies were observed between the results obtained with the PCR-method and those obtained serologically. The gene frequencies obtained from 200 unrelated Finns were 0.86 and 0.14 for HPA-1a and -1b, 0.91 and 0.09 for HPA-2a and -2b, 0.59 and 0.41 for HPA-3a and -3b and 0.95 and 0.05 for HPA-5a and -5b. The frequency of the HPA-5b allele (10%) is lower in Finns than in Central- or South-European populations (20-30%). The HPA-1, -2 and -3 frequencies did not deviate from those observed in other European populations. The rare HPA-6b antigen was observed in three of 127 individuals from south-eastern Finland (2.4%), which suggests that the frequency of this allele in Finland is higher than previously thought.
Kekomäki
S
S
Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Partanen
J
J
Kekomäki
R
R
D016824:Antigens, Human Platelet / Q000097:blood* / Q000235:genetics*; D005387:Finland; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D039661:Integrin beta3; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
C071221:2b alloantigen, human; C044561:3a alloantigen, human; C083448:3b alloantigen, human; C071092:5a alloantigen, human; C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; C083451:human platelet antigen 1b