[The effect of the intragastric administration of prostaglandin E2 on mucus secretion in dogs].
3 mcg/kg PGE2 did not affect secretion of gastric juice, H+, pepsin and biochemical structure of secreted glycoproteins in dogs. However, a decrease in the quantity of degraded glycoproteins entailed an increase in polymeric glycoproteins in the general pool of glycoproteins of the mucous layer which contributed to formation of a more solid and viscous mucous gel.
Krivova
N A
NA
Selivanova
T I
TI
Lapteva
T A
TA
Zaeva
O B
OB
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D015232:Dinoprostone / Q000008:administration & dosage*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D006023:Glycoproteins / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009093:Mucus / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013270:Stomach
D000897:Anti-Ulcer Agents; D006023:Glycoproteins; D002217:Carbachol; D010418:Pentagastrin; D015232:Dinoprostone