Pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in the neonatal macaque (Macaca nemestrina).
Our objective was to determine whether age effects the pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in the neonatal pig-tailed macaque (Macaca nemestrina). The drug (5 mg/kg of body weight) was administered serially as a single intravenous bolus to the same four macaques at the ages of < 1 week, 1 month, and 4 months. Plasma clearance at < 1 week of age was significantly lower (P < 0.05) than the corresponding values at 1 month and 4 months. Our data indicate that the pharmacokinetics of stavudine change significantly with age in M. nemestrina.
Keller
R D
RD
Department of Pharmaceutics, University of Washington, Seattle 98195, USA.
Nosbisch
C
C
Unadkat
J D
JD
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008254:Macaca nemestrina; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018119:Stavudine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine