Mutations in the p53 tumour suppressor gene in thyroid tumours of children from areas contaminated by the Chernobyl accident.
The number of p53 mutations observed in thyroid carcinomas derived from children from areas contaminated by Chernobyl accident is higher compared with studies on patients who had no contact with radioactivity.
Hillebrandt
S
S
Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Germany.
Streffer
C
C
Reiners
C
C
Demidchik
E
E
D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000209:etiology / Q000235:genetics*; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics / Q000528:radiation effects; D004586:Electrophoresis / Q000379:methods; D005091:Exons; D005260:Female; D005784:Gene Amplification; D016158:Genes, p53 / Q000528:radiation effects*; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011210:Power Plants; D018788:Radioactive Hazard Release; D013964:Thyroid Neoplasms / Q000209:etiology / Q000235:genetics*; D014455:Ukraine
D004273:DNA, Neoplasm