Syntheses and effect of bursin and it analogs on the reduced B lymphocytes of uremic patients.
A selective B-lymphocyte-differentiating tripeptide, bursin, H-Lys-His-Gly-NH2, and its 10 analogs were synthesized by a solid-phase method and were tested for their effect on reduced B lymphocytes of uremic patients. Incubation of peripheral lymphocytes isolated from uremic patients with the synthetic bursin showed an enhancing effect on the reduced B lymphocytes. Of the s synthetic analogs, [Sar3]bursin exhibited the most potent effect.
Abiko
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T
Kidney Research Laboratory, Kojinkai, Sendai, Japan.
Sekino
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H
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology*; D002060:Bursa of Fabricius / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008231:Lymphopenia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014511:Uremia / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; C016281:bursopoietin