title: Phosphoinositides as regulators in membrane traffic.
abstract: Phosphorylated products of phosphatidylinositol play critical roles in the regulation of membrane traffic, in addition to their classical roles as second messengers in signal transduction at the cell surface. Growing evidence suggests that phosphorylation-dephosphorylation of the polar heads of phosphoinositides (polyphosphorylated inositol lipids) in specific intracellular locations signals either the recruitment or the activation of proteins essential for vesicular transport. Cross talk between phosphatidylinositol metabolites and guanosine triphosphatases is an important feature of these regulatory mechanisms.
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: P
authors.initials: P
authors.lastname: De Camilli
authors.forename: S D
authors.initials: SD
authors.lastname: Emr
authors.forename: P S
authors.initials: PS
authors.lastname: McPherson
authors.forename: P
authors.initials: P
authors.lastname: Novick
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D018699:Coated Vesicles / Q000378:metabolism; D004705:Endocytosis; D005089:Exocytosis; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D010766:Phosphorylation; D015003:Yeasts / Q000378:metabolism
chemical_list: D007295:Inositol Phosphates; D008565:Membrane Proteins; D010716:Phosphatidylinositols; D020558:GTP Phosphohydrolases