Effects of estrogenic chemicals on development.
The sum of the evidence supports the necessity to continue to investigate the developmental effects of estrogenic and antiestrogenic compounds when exposure occurs early in life. Additional studies will answer questions relevant to the molecular definition of the developmental or carcinogenic effects of estrogens such as hormone-induced gene alterations. These studies also support the need to use the neonatal mouse model to demonstrate the consequences of reproductive and nonreproductive stem-cell exposure to estrogenic compounds.
Jones
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LA
Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. lovell_jones@gyn.mda.uth.tmc.edu
Hajek
R A
RA
D000818:Animals; D000831:Animals, Newborn; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced*; D025063:Chromosome Disorders; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004967:Estrogens / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D024510:Muscle Development; D009132:Muscles / Q000187:drug effects
D002274:Carcinogens, Environmental; D004967:Estrogens