In vitro growth inhibition activities of recombinant feline interferon on all lines derived from canine tumours.
To evaluate the anti-tumour effect of recombinant feline interferon (rFeIFN) against canine neoplastic cells, the antiproliferation and anti-colony-forming activities of rFeIFN were investigated in vitro, using four cell lines derived from canine tumours; oral acanthomatous epulis (MCA-B1), mammary benign mixed tumour (MCM-B2), squamous cell carcinoma (CSCC), and malignant melanoma (CMC-1). The rFeIFN had a dose-dependent inhibitory effect on the cell growth and colony formation of all the cell lines, although the degree of inhibition was lower than that in the feline cell lines used as a positive control, and the sensitivity of the cells to rFeIFN differed.
Tateyama
S
S
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan.
Priosoeryanto
B P
BP
Yamaguchi
R
R
Uchida
K
K
Ogiwara
K
K
Suchiya
A T
AT
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary; D002371:Cat Diseases / Q000473:pathology; D002415:Cats; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007372:Interferons / Q000494:pharmacology*; D015674:Mammary Neoplasms, Animal / Q000473:pathology; D008545:Melanoma / Q000473:pathology / Q000662:veterinary; D009062:Mouth Neoplasms / Q000473:pathology / Q000662:veterinary; D003557:Phyllodes Tumor / Q000473:pathology / Q000662:veterinary; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D011994:Recombinant Proteins; D007372:Interferons