title: Ultrasound biomicroscopic study of ciliary body thickness after topical application of pharmacologic agents.
abstract: OBJECTIVE
  To examine the changes in ciliary body thickness after topical application of pilocarpine, cyclopentolate hydrochloride, and PhXA41, a prostaglandin F2alpha analog.
  
  
  METHODS
  We used high-frequency Humphrey UBM840 ultrasound biomicroscope to examine 36 healthy young Japanese subjects.
  
  
  RESULTS
  The mean ciliary body thickness increased from 0.67 +/- 0.07 mm to 0.073 +/- 0.08 mm (P < .01) after application of 2% pilocarpine; 1% cyclopentolate hydrochloride and 0.005% PhXA41 decreased the mean ciliary body thickness from 0.75 +/- 0.07 mm to 0.69 +/- 0.05 mm (P < .05) and from 0.78 +/- 0.06 mm to 0.75 +/- 0.06 mm (P < .01), respectively.
  
  
  CONCLUSIONS
  Our ultrasound study clearly indicates that pilocarpine increased comparative thickness of the ciliary body by 8.3%, whereas PhXA41 decreased comparative thickness by 3.3% in a manner similar to cyclopentolate hydrochloride.
authors.affiliation: Department of Ophthalmology, Hiroshima University School of Medicine, Japan.
authors.forename: H K
authors.initials: HK
authors.lastname: Mishima
authors.forename: K
authors.initials: K
authors.lastname: Shoge
authors.forename: M
authors.initials: M
authors.lastname: Takamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Kiuchi
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000886:Anthropometry; D002924:Ciliary Body / Q000000981:diagnostic imaging* / Q000187:drug effects; D003519:Cyclopentolate / Q000008:administration & dosage*; D004311:Double-Blind Method; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008853:Microscopy; D009883:Ophthalmic Solutions; D010277:Parasympathomimetics / Q000008:administration & dosage*; D010862:Pilocarpine / Q000008:administration & dosage*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D014463:Ultrasonography
chemical_list: D009883:Ophthalmic Solutions; D010277:Parasympathomimetics; D011461:Prostaglandins F, Synthetic; D010862:Pilocarpine; D000077338:Latanoprost; D003519:Cyclopentolate