Fatigue of chronically overused motor units in prior polio patients.
This study was undertaken to investigate the mechanisms underlying fatigue of chronically overused motor units (MUs). The force of the tibialis anterior muscle (TA) and the firing properties of single MUs were studied during prolonged maximum voluntary effort in 10 prior polio patients selected such that daily living required all residual TA power. Almost all TA fibers were hypertrophic type I. Activities of intermyofibrillar succinate dehydrogenase (SDH) and calcium-stimulated myofibrillar adenosine triphosphatase (ATPase) were measured in single TA fibers from a representative patient. Neither insufficient motoneuron activation nor peripheral blocking of the electrical impulse played a major role in the loss of force during prolonged contraction or for slow recovery after contraction. The ratio of SDH to calcium-stimulated ATPase, representing the relation between energy resynthesis and energy utilization, was significantly (P < 0.001) lower in prior polio patients (0.230 +/- 0.096) compared to control (0.515 +/- 0.097) type I fibers.
Grimby
L
L
Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
Tollbäck
A
A
Müller
U
U
Larsson
L
L
D000368:Aged; D000704:Analysis of Variance; D001706:Biopsy; D000252:Calcium-Transporting ATPases / Q000032:analysis; D004576:Electromyography; D005260:Female; D005528:Foot / Q000294:innervation; D006801:Humans; D007866:Leg / Q000294:innervation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009068:Movement; D009119:Muscle Contraction; D018763:Muscle Fatigue; D018485:Muscle Fibers, Skeletal / Q000201:enzymology / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D011051:Poliomyelitis / Q000473:pathology / Q000503:physiopathology*; D012016:Reference Values; D013385:Succinate Dehydrogenase / Q000032:analysis; D013997:Time Factors; D016138:Walking
D013385:Succinate Dehydrogenase; D000252:Calcium-Transporting ATPases