title: RES-1149-1 and -2, novel non-peptidic endothelin type B receptor antagonists produced by Aspergillus sp. II. Structure determination and derivatization.
abstract: The structures of two novel non-peptidic endothelin type B receptor antagonists, RES-1149-1 and -2 were determined by spectroscopic methods. Several derivatives were synthesized from RES-1149-1 for biological assay.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Uosaki
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
mesh_terms: D065128:Endothelin Receptor Antagonists; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D044023:Receptor, Endothelin B; D013764:Tetrahydronaphthalenes / Q000737:chemistry*
chemical_list: D065128:Endothelin Receptor Antagonists; C098351:RES 1149-1; C098352:RES 1149-2; D044023:Receptor, Endothelin B; D013764:Tetrahydronaphthalenes