The jerangolids: A family of new antifungal compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties of jerangolid A.
An antifungal activity was detected in the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 307. The activity was excreted into the supernatant during the log and early stationary phase. When the organism was fermented in the presence of the adsorber resin XAD-16, the metabolite was quantitatively bound to the resin. The main component, jerangolid A, has structural similarities to ambruticin, which is also produced by strains of Sorangium cellulosum.
Gerth
K
K
GBF, Gesellschaft fur Biotechnologische Forschung, Abteilung Naturstoffbiologie, Braunschweig, Germany.
Washausen
P
P
Hofle
G
G
Irschik
H
H
Reichenbach
H
H
D000935:Antifungal Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D009231:Myxococcales / Q000378:metabolism*; D011714:Pyrans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D000935:Antifungal Agents; D011714:Pyrans; C098368:jerangolid A