title: Intracellular distribution of Hg2+ applied to epidermis in mice. Analysis of subcellular fractions.
abstract: To analyze the permeation of Hg2+ in the epidermis as contact dermatitis allergen, the carrier substances from the HgCl2-treated epidermis were isolated. The peak amount of Hg2+ in the epidermis of mouse tail skin was observed at 12 h after the painting. Thereafter, it remained almost stationary. In the analysis of subcellular fractions, the nuclei fraction showed the highest Hg2+ incorporation, while the soluble protein fraction showed the lowest.
authors.affiliation: Department of Removable Prosthodontics, Nagasaki University School of Dentistry, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Daian
authors.forename: T
authors.initials: T
authors.lastname: Namikoshi
authors.forename: H
authors.initials: H
authors.lastname: Fujii
mesh_terms: D000818:Animals; D004817:Epidermis / Q000378:metabolism*; D005260:Female; D007425:Intracellular Membranes / Q000378:metabolism*; D008628:Mercury / Q000493:pharmacokinetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D010539:Permeability; D013347:Subcellular Fractions / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D008628:Mercury