Decrease of interferon-induced 2',5'-oligoadenylate synthetase activity in cirrhotic rat liver.
We evaluated the effect of hepatic fibrosis on the induction of hepatic 2',5'-oligoadenylate synthetase (2-5AS) by interferon (IFN) in a rat model of liver cirrhosis, induced with thioacetamide. Although there was no difference in serum 2-5AS activity between the control and cirrhotic rats given murine IFN, 2-5AS activity in the liver homogenates of cirrhotic rats was significantly lower than in the controls (105 +/- 18.5 vs. 171 +/- 10.2 pmol/micrograms, p < 0.01). These results suggested that hepatic fibrosis attenuated the effect of IFN and one of the reasons for this may be the decreased induction of hepatic 2-5AS activity after IFN administration in the presence of a cirrhotic liver.
Miyajima
I
I
Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Sata
M
M
Uchimura
Y
Y
Suzuki
H
H
Tanikawa
K
K
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D000818:Animals; D007372:Interferons / Q000494:pharmacology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide
D013853:Thioacetamide; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase