Hypoxic pulmonary hypertension: haemodynamic changes after oxygen and various vasodilators in the same patient at different time periods.
The haemodynamic response to oxygen breathing and various vasodilatory drugs (Nifedipine, Ketanserin, Dihydralazine, Nitroglycerin, Iso-Mack, Nit-Ret) was repeatedly measured at different time intervals (4-24 months) in 10 males with hypoxic pulmonary hypertension due to chronic obstructive lung disease. It was found that the pulmonary artery mean pressure and pulmonary vascular resistance changes are stable in most of the patients, discordant reactions being exceptional and of small degree. The authors consider these findings important in the therapeutical decision making for longterm oxygen therapy and or vasodilatory drug administration.
Král
H
H
2nd Department of Medicine, Charle's University, Hradec Králové.
Hamet
A
A
Cernohorský
D
D
Stásek
J
J
Tilser
P
P
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D000860:Hypoxia / Q000150:complications*; D008173:Lung Diseases, Obstructive / Q000150:complications; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D011652:Pulmonary Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents