Simultaneous occurrence of osteosarcoma and osteochondroma following treatment of neuroblastoma with chemotherapy, radiotherapy, and bone marrow transplantation.
Radiation-induced bone changes and second malignancies, as well as benign tumors, following bone marrow transplantation are being reported with increasing frequency. An osteosarcoma of the fourth right rib and an osteochondroma of the left scapula developed in a long-term survivor of abdominal neuroblastoma treated with chemotherapy, local radiation, and bone marrow transplantation. All these treatment modalities are known to induce neoplasia.
Poustchi-Amin
M
M
Department of Radiology, Division of Pediatric Radiology, Schneider Children's Hospital, Long Island Jewish Medical Center, 270-05 76th Avenue, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA.
Leonidas
J C
JC
Elkowitz
S S
SS
D000008:Abdominal Neoplasms / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009447:Neuroblastoma / Q000628:therapy*; D015831:Osteochondroma / Q000209:etiology*; D012516:Osteosarcoma / Q000209:etiology*; D014916:Whole-Body Irradiation / Q000009:adverse effects*