QSAR of N2-phenylguanidines as inhibitors of herpes simplex virus-1 thymidine kinase.
Quantitative structure-activity relationships were developed to account for inhibition of Herpes simplex virus type 1 by N2-phenylguanines. It was found that the hydrophobic and especially the steric properties of the substituents determine the relative potencies of the derivatives.
Hadjipavlou-Litina
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Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000201:enzymology*; D012044:Regression Analysis; D013329:Structure-Activity Relationship; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D006146:Guanidines; D013937:Thymidine Kinase