Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives.
1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations. 2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives. 3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.
Griffiths
L R
LR
Molecular Genetics Laboratory, School of Health Sciences, NHS Faculty, Griffith University, Gold Coast, Queensland, Australia.
Nyholt
D R
DR
Curtain
R P
RP
Gaffney
P T
PT
Morris
B J
BJ
D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D004276:DNA, Satellite / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
D004276:DNA, Satellite; D005819:Genetic Markers; D011973:Receptors, LDL; D002784:Cholesterol