Dependence of nitrogen- and phosphorus-regulation of beta-lactam antibiotic production by Streptomyces clavuligerus on aeration level.
Interference with beta-lactam production in Streptomyces clavuligerus by ammonium and phosphate ions, normally observed with optimum levels of aeration, was eliminated by restriction of the air supply. Under such a restriction, ammonium slightly stimulated and phosphate markedly stimulated beta-lactam antibiotic production. These are rare examples of 'regulation reversal' by an environmental modification.
Fang
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Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Demain
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D000388:Air; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D005285:Fermentation; D009584:Nitrogen / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000378:metabolism / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D000644:Quaternary Ammonium Compounds; D047090:beta-Lactams; D010758:Phosphorus; D009584:Nitrogen; D011188:Potassium