title: Tumorigenesis and cell evolution.
abstract: All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibility that tumorigenesis is a two-stage process. Finally, I suggest that our understanding of the molecular level of tumorigenesis be reappraised.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Cai
mesh_terms: D005075:Biological Evolution; D002468:Cell Physiological Phenomena; D002471:Cell Transformation, Neoplastic; D002477:Cells / Q000166:cytology / Q000473:pathology; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D011995:Recombination, Genetic