Involvement of the adenylyl cyclase signaling system in the action of insulin and mollusk insulin-like peptide.
Involvement of the adenylyl cyclase signaling system in the mechanism of action of the mammalian insulin and epidermal growth factor as well as of insulin-like peptide isolated from the bivalve mollusk Anodonta cygnea has been studied. It was shown for the first time that insulin and insulin-like peptide exert in vitro the GTP-dependent stimulating action on the adenylyl cyclase activity. Epidermal growth factor has an analogous effect. Effectiveness of the peptides decreased in the order insulin-like peptide > epidermal growth factor > insulin in the foot smooth muscles of A. cygnea and insulin > epidermal growth factor > insulin-like peptide in the skeletal muscles of rat.
Pertseva
M N
MN
Laboratory of Evolution of Biochemical Communication Systems, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Petersburg, Russia.
Plesneva
S A
SA
Shpakov
A O
AO
Rusakov YuI
Kuznetsova
L A
LA
D000262:Adenylyl Cyclases / Q000187:drug effects*; D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects*
D007328:Insulin; D010446:Peptide Fragments; D004815:Epidermal Growth Factor; D000262:Adenylyl Cyclases