title: High-impact poly(L/D-lactide) for fracture fixation: in vitro degradation and animal pilot study.
abstract: The impact strength of amorphous lactide copolymers can be significantly improved by blending with biodegradable rubbers. Rubber toughening of amorphous poly(85L/15D -lactide) with the copolymer poly (50/50-trimethylenecarbonate-co-epsilon-caprolactone) results in a high-impact polymer (PDLLA/P(TMC-CL)). In vitro, the PDLLA/P(TMC-CL) blend retained its tensile and impact strength for a long period of time. Up to 45 weeks, the amount of water absorbed by the blend remained very low and no significant mass loss was observed. To test the suitability for fracture fixation, in a dog study mandibular fractures were fixated with PDLLA/P(TMC-CL) bone plates and screws. Bone healing was uneventful without premature failure of the implants. Although long-term degradation studies have to be carried out, PDLLA/P(TMC-CL) seems to be promising for application in fracture fixation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Tams
authors.forename: C A
authors.initials: CA
authors.lastname: Joziasse
authors.forename: R R
authors.initials: RR
authors.lastname: Bos
authors.forename: F R
authors.initials: FR
authors.lastname: Rozema
authors.forename: D W
authors.initials: DW
authors.lastname: Grijpma
authors.forename: A J
authors.initials: AJ
authors.lastname: Pennings
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D001860:Bone Plates / Q000592:standards; D001863:Bone Screws / Q000592:standards; D002209:Caprolactam; D004195:Disease Models, Animal; D004285:Dogs; D005592:Fracture Fixation; D017102:Fracture Healing / Q000502:physiology; D007773:Lactates; D019344:Lactic Acid; D008337:Mandibular Fractures / Q000601:surgery*; D010865:Pilot Projects; D011091:Polyesters; D011108:Polymers; D019736:Prostheses and Implants / Q000592:standards; D013718:Tensile Strength
chemical_list: D007773:Lactates; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D002209:Caprolactam; C000362:capron