[Efficacy of various methods for preoperative vaginal antisepsis].
In a prospective clinical study we investigated 115 patients prior to vaginal surgical interventions to determine the antimicrobial efficacy of six different procedures for vaginal antisepsis. To sample the microorganisms we used a cotton swab moistened with a neutralising fluid. Immediately after the time of action of the antiseptic procedures (3 minutes), providone-iodine solution, applied undiluted or diluted 1:10, yielded the strongest median reduction of the vaginal flora (log RF 3.60 and 2.68, respectively). Of three detergents with antiseptic efficacy, octenidine 0.1% was the most efficient formula (log RF 2.32). After 30 minutes the log reduction factors (log RF) of almost all procedures (log RF 2.79-3.25) were in a fairly close range, excepting chlorohexidine 0.05% (log RF 2.07). Overall, the antiseptic detergents showed a marked residual effect, which was less pronounced, if at all, with providone-iodine solutions. A germ-reducing effect of povidone-iodine vaginal suppositories, applied 2 to 3 hrs prior to surgery, was not confirmed, while additional findings indicated that providone-iodine solution applied with the help of a vaginal douche yields a similarly strong germ reduction as the application by means of a ball swabs.
Enzelsberger
H
H
Univ.-Frauenklinik Wien.
Eppel
W
W
Dorninger
G
G
Wewalka
G
G
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000009:adverse effects; D000985:Antisepsis / Q000379:methods*; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005831:Genital Diseases, Female / Q000382:microbiology / Q000601:surgery*; D006801:Humans; D007045:Hysterectomy, Vaginal; D007097:Imines; D008875:Middle Aged; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000009:adverse effects; D011725:Pyridines / Q000008:administration & dosage* / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D014621:Vagina / Q000382:microbiology*
D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D011206:Povidone-Iodine; C034213:octenidine; D002710:Chlorhexidine