title: Cacospongionolide B, a new sesterterpene from the sponge Fasciospongia cavernosa.
abstract: Cacospongionolide B [2a], a new cacospongionolide-related sesterterpene, has been isolated from the Adriatic sponge Fasciospongia cavernosa. The structure was elucidated by spectral and chemical means. The antimicrobial activity and brine shrimp and fish lethalities of 2a are reported.
authors.affiliation: Istituto per la Chimica di Molecole di Interesse Biologico CNR, Napoli, Italy.
authors.forename: S
authors.initials: S
authors.lastname: De Rosa
authors.forename: A
authors.initials: A
authors.lastname: Crispino
authors.forename: A
authors.initials: A
authors.lastname: De Giulio
authors.forename: C
authors.initials: C
authors.lastname: Iodice
authors.forename: R
authors.initials: R
authors.lastname: Pronzato
authors.forename: N
authors.initials: N
authors.lastname: Zavodnik
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000107:Acetylation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D003532:Cyprinodontiformes / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011714:Pyrans; C098384:cacospongionolide B; D015107:4-Butyrolactone