title: Sternal cleft: case report and review of a series of nine patients.
abstract: Cleft sternum is a rare malformation due to partial or total failure of sternal fusion at an early stage of embryonic development. Sternal clefts can be classified as superior, inferior, or complete. Here we report on a 2-year-old boy with inferior sternal cleft and complex cardiac malformation. We review a series of 9 children with sternal clefts, referred to us over a 10-year period. Hypothetical mechanisms for this developmental anomaly are discussed.
authors.affiliation: Département de Pédiatrie, Hôpital des Enfants Malades, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Héron
authors.forename: S
authors.initials: S
authors.lastname: Lyonnet
authors.forename: L
authors.initials: L
authors.lastname: Iserin
authors.forename: A
authors.initials: A
authors.lastname: Munnich
authors.forename: J P
authors.initials: JP
authors.lastname: Padovani
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D005801:Genes, Homeobox; D006330:Heart Defects, Congenital / Q000209:etiology / Q000235:genetics; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D013249:Sternum / Q000002:abnormalities*