title: A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation.
abstract: Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.
authors.affiliation: Biomedical Research Laboratories, Sankyo Co., Ltd, Tokyo 140, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takatsu
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawase
authors.forename: R
authors.initials: R
authors.lastname: Enokita
authors.forename: T
authors.initials: T
authors.lastname: Okazaki
authors.forename: H
authors.initials: H
authors.lastname: Matsukawa
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sakaida
authors.forename: T
authors.initials: T
authors.lastname: Kagasaki
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Tanzawa
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D005966:Glucuronidase; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D000099175:Heparanase
chemical_list: D004791:Enzyme Inhibitors; D005966:Glucuronidase; D006026:Glycoside Hydrolases; D010880:Piperidines; D000099175:Heparanase; C011353:siastatin