title: Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype.
authors.affiliation: Department of Pathology, University of Cambridge, United Kingdom.
authors.forename: P
authors.initials: P
authors.lastname: Digard
authors.forename: W R
authors.initials: WR
authors.lastname: Bebrin
authors.forename: D M
authors.initials: DM
authors.lastname: Coen
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001665:Binding Sites; D004252:DNA Mutational Analysis / Q000379:methods*; D004257:DNA Polymerase II / Q000737:chemistry* / Q000378:metabolism*; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase; D004352:Drug Resistance, Microbial; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005090:Exodeoxyribonucleases; D018259:Herpesvirus 1, Human / Q000378:metabolism; D046911:Macromolecular Substances; D018139:Simplexvirus / Q000201:enzymology* / Q000235:genetics; D013379:Substrate Specificity; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D046911:Macromolecular Substances; D014764:Viral Proteins; D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C043417:DNA polymerase, Simplexvirus; D000212:Acyclovir