[Influence of oral isosorbide dinitrate (ISDN) on parameters of blood flow in the coeliac trunk evaluated with doppler sonography].
Blood flow in the coeliac trunk was measured before and after oral application of ISDN (isosorbitol dinitrate) 10 or 20 mg. Clinical prognostic value of this test was evaluated. Investigation were carried out with a duplex-Doppler pulsatory wave. The quantitative hemodynamic method with estimation of PI and RI was applied to exclude the effect of angle and the vessel diameter. 44 healthy volunteers were examined. The ultrasonograph ACUSON 128 was used with the linear and sectorial head 3.5 MHz enabling measurement of the pulsatory wave (Doppler). All persons were divided into 4 groups: according to sex, the age, the dose of nitrate and the groups given placebo. Application of the ISDN led to increase values PI and RI. Application of placebo had no influence on the blood flow.
Trzaska-Michalska
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II Katedry i Kliniki Chorób Wewnetrznych Slaskiej Akademii Medycznej w Katowicach.
Kalina
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Z
D000293:Adolescent; D000328:Adult; D002445:Celiac Artery / Q000000981:diagnostic imaging* / Q000187:drug effects*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow / Q000187:drug effects; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D018616:Ultrasonography, Doppler, Duplex; D018617:Ultrasonography, Doppler, Pulsed; D014655:Vascular Resistance / Q000187:drug effects
D007548:Isosorbide Dinitrate