Transient thrombotic state after abrupt discontinuation of heparin in percutaneous coronary angioplasty.
Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.
Smith
A J
AJ
Cardiac Unit, Massachusetts General Hospital, Boston 02114, USA.
Holt
R E
RE
Fitzpatrick
J B
JB
Palacios
I F
IF
Gold
H K
HK
Werner
W
W
Bovill
E G
EG
Fuster
V
V
Jang
I K
IK
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000150:complications / Q000188:drug therapy; D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000139:chemically induced; D010314:Partial Thromboplastin Time; D011446:Prospective Studies; D013375:Substance Withdrawal Syndrome; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced*
D000925:Anticoagulants; D006493:Heparin