title: Comparison of 99Tcm-sestamibi and 201Tl-chloride to estimate right ventricular overload in children.
abstract: To evaluate right ventricular overload in paediatric patients with congenital cardiac disease (n = 25), the uptakes of 201Tl and 99Tcm-sestamibi (99Tcm-MIBI) were compared. 99Tcm-MIBI showed a clearer myocardial border and better contrast between the myocardium and ventricular cavity. Although hepatic activity may influence right ventricular myocardial activity, it did not have a significant effect on the quantitative data of myocardial uptake. The right ventricle-to-background (RV/BG) ratio and left ventricle-to-background (LV/BG) ratio were lower with 99Tcm-MIBI than with 201Tl, and the RV/LV count ratio was also significantly lower in the 99Tcm-MIBI study. The parameters of the RV/LV count ratios showed good correlations between the 201Tl and 99Tcm-MIBI studies. The RV/LV pressure ratio was estimated using the formula: RV/LV pressure ratio = 0.99 (RV/LVav) + 0.02 (R = 0.90, P < 0.0001). To estimate RV overload or the RV/LV pressure ratio scintigraphically, we conclude that 99Tcm-MIBI be used instead of 201Tl. 99Tcm-MIBI studies are a good adjunct to perfusion studies when estimating RV pressure.
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: J
authors.initials: J
authors.lastname: Taki
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Tonami
authors.forename: K
authors.initials: K
authors.lastname: Hisida
mesh_terms: D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D016277:Ventricular Function, Left / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi