title: Structure and effects of a kinin potentiating fraction F (AppF) isolated from Agkistrodon piscivorus piscivorus venom.
abstract: The contractile action of bradykinin on isolated smooth muscles is known to be potentiated by special peptides isolated from snake venoms and other animal sources. A fraction F (AppF) has been derived from Agkistrodon piscivorus piscivorus venom. This fraction does not increase the depressor effect of bradykinin n blood pressure, potentiates the action of bradykinin on isolated guinea-pig ileum and prolongs the duration of relaxation in isolated rat duodenum. This fraction was able to inhibit the conversion of angiotensin I to angiotensin II in vitro. The primary structure of this decapeptide is given.
authors.affiliation: Departamento de Bioquimica e Biofisica, Instituto Butantan, São Paulo, Brazil.
authors.forename: L A
authors.initials: LA
authors.lastname: Ferreira
authors.forename: T
authors.initials: T
authors.lastname: Möllring
authors.forename: F L
authors.initials: FL
authors.lastname: Lebrun
authors.forename: M
authors.initials: M
authors.lastname: Raida
authors.forename: R
authors.initials: R
authors.lastname: Znottka
authors.forename: G G
authors.initials: GG
authors.lastname: Habermehl
mesh_terms: D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000378:metabolism / Q000494:pharmacology; D003435:Crotalid Venoms / Q000737:chemistry*; D004357:Drug Synergism; D006168:Guinea Pigs; D013058:Mass Spectrometry; D009130:Muscle, Smooth / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003435:Crotalid Venoms; D009842:Oligopeptides; D010446:Peptide Fragments; C006791:bradykinin potentiating factors; D000804:Angiotensin II; D000803:Angiotensin I; D001920:Bradykinin