title: Persistence: a new statistic for characterizing ion-channel activity.
abstract: We introduce and illustrate by examples a new statistical technique, the persistence function, for characterizing ion-channel activity in a single-channel patch-clamp recording. Persistence is a function of both current and time. It is the probability that the current is at a given level (conditional on it having been at that level at an earlier time). Viewed as a function of current it exhibits the prominent conductance levels present in the recording, and viewed as a function of time for a conductance level it portrays the kinetics at that level.
authors.affiliation: Department of Physics, University of California, San Diego, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Fredkin
authors.forename: J A
authors.initials: JA
authors.lastname: Rice
authors.forename: D
authors.initials: D
authors.lastname: Colquhoun
authors.forename: A J
authors.initials: AJ
authors.lastname: Gibb
mesh_terms: D007473:Ion Channels; D007700:Kinetics; D008954:Models, Biological; D018408:Patch-Clamp Techniques; D016194:Receptors, N-Methyl-D-Aspartate; D013223:Statistics as Topic
chemical_list: D007473:Ion Channels; D016194:Receptors, N-Methyl-D-Aspartate