Activity of iPMS and nPMS in mouse bone marrow micronucleus assays: comparison with mouse dominant lethal assay data.
isoPropyl methanesulphonate (iPMS) and its n-propyl analogue (nPMS) are shown to be active in mouse bone marrow micronucleus assays using male CBA, male and female (C3H/El X 102/E1)Fl and male and female Muta Mouse mice. iPMS was significantly more active than nPMS. No significant strain or gender differences were observed. These findings reflect the differences reported earlier for these two chemicals in mouse dominant lethal mutation assays. The earlier described dominant lethal assay data are represented schematically and discussed.
Adler
I D
ID
GSF-Institut fur Saugetiergenetik, Neuherberg, D-85758 Oberschleissheim, Germany.
Tinwell
H
H
Kliesch
U
U
Ashby
J
J
D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003433:Crosses, Genetic; D004305:Dose-Response Relationship, Drug; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D008698:Mesylates / Q000633:toxicity*; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011247:Pregnancy; D012727:Sex Characteristics; D013045:Species Specificity
D000477:Alkylating Agents; D008698:Mesylates; D009153:Mutagens; C046861:n-propyl methane sulfonate; C002531:isopropylmethanesulfonate