[The effect of beta-casomorphin-7 on the level of food and defense motivations in different types of learning].
The effects of intraperitoneal administration of the heptapeptide beta-casomorphin-7 (beta-C-7) on learning were investigated in white rats using T-maze, active and passive avoidance tests. The substance injected in the dose of 5 mg/kg 5 min prior to training accelerated the acquisition of food-reinforced task increasing the number of correct trials in T-maze. The same injection in the dose of 1 mg/kg impaired the acquisition of avoidance tasks. The heptapeptide didn't influence food motivation and consolidation of memory trace. The data obtained support the idea that beta-C-7 attenuated manifestations of defensive motivation.
Maklakova
A S
AS
Nazarenko
I V
IV
Dubynin
V A
VA
Nezavibat'ko
V N
VN
Alfeeva
L A
LA
Kamenskiĭ
A A
AA
D000161:Acoustic Stimulation; D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009042:Motivation; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012054:Reinforcement, Psychology; D018709:Statistics, Nonparametric
D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; C041128:beta-casomorphin 7