Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
In the mammalian nervous system, several basic helix-loop-helix (bHLH) proteins have been identified that may play essential roles in neurogenesis or neural development. This paper describes a novel bHLH protein in rat brain, which has a bHLH domain highly homologous with that of MATH-2 and NeuroD. On the other hand, the amino-acid sequence of the other regions had little homology with those of the known proteins. This protein consists of 381 amino acids and was detected only in neural tissue, indicating that it has an important role specific to neuronal activities.
Kume
H
H
Laboratory of Neurochemistry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan.
Maruyama
K
K
Tomita
T
T
Iwatsubo
T
T
Saido
T C
TC
Obata
K
K
D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D001921:Brain / Q000378:metabolism*; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018257:Helix-Loop-Helix Motifs; D006624:Hippocampus / Q000378:metabolism*; D017403:In Situ Hybridization; D066298:In Vitro Techniques; D008297:Male; D008322:Mammals; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis* / Q000737:chemistry*; D009928:Organ Specificity; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry*
D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D014157:Transcription Factors; C490554:Neurod6 protein, rat