A new drug delivery system using plasma-irradiated pharmaceutical aids. VI. Controlled release of theophylline from plasma-irradiated double-compressed tablet composed of water-soluble polymers as a wall material.
The rapid drug release from a double-compressed tablet containing theophylline with the water-soluble polymer polymethacrylic acid (PMAA) or polyacrylamide (PAAm) used as a wall material can be suppressed by argon plasma irradiation and changed into the slow release due to a decrease in the solubility of water-soluble polymers used as the outer layer. This report is the first to deal with an attempt to control the release of drugs by controlling polymer solubility, and to fabricate a completely soluble controlled release type of drug delivery system (DDS) making use of plasma processing.
Kuzuya
M
M
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Japan.
Ishikawa
M
M
Noguchi
T
T
Niwa
J
J
Kondo
S
S
D000180:Acrylic Resins / Q000737:chemistry* / Q000528:radiation effects*; D001128:Argon / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D010592:Pharmaceutic Aids / Q000737:chemistry* / Q000528:radiation effects*; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000528:radiation effects*; D012995:Solubility; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D000099166:Polyacrylamides
D000180:Acrylic Resins; D001128:Argon; D003692:Delayed-Action Preparations; D010592:Pharmaceutic Aids; D011109:Polymethacrylic Acids; D013607:Tablets; D013806:Theophylline; D014867:Water; D000099166:Polyacrylamides; C030613:polymethacrylic acid