Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.
The distribution of bone morphogenetic protein (BMP) type I receptors and the activin type I receptor (ActR-I) was investigated in 16 cases of human glioma and five cases of non-tumourous gliosis tissue by immunohistochemical technique. Both BMP type IA (BMPR-IA) and the type IB (BMPR-IB) receptors were detected in human glioma cells. A significant increase in BMPR-IB in tumour cells was observed in malignant glioma compared with both low-grade astrocytomas (n=16, P<0.005) and gliosis (n=13, P<0.001). However, enhancement of BMPR-IA staining was moderate and ActR-I staining was only weakly expressed in the malignant glioma tumours. Osteogenic protein (OP)-1/BMP-7, which is known to bind BMPR-IA, BMPR-IB and ActR-I, was expressed in nervous tissue and was also detected in anaplastic areas of malignant glioma. In contrast to the tissue materials, BMPR-IA was expressed to a stronger degree than BMPR-IB in human glioma cell lines; the growth of these cells was suppressed by OP-1. These results suggest the presence of BMP receptors and a functional role for BMPs in malignant glioma.
Yamada
N
N
Ludwig Institute for Cancer Research, Uppsala, Sweden.
Kato
M
M
ten Dijke
P
P
Yamashita
H
H
Sampath
T K
TK
Heldin
C H
CH
Miyazono
K
K
Funa
K
K
D029404:Activin Receptors; D000818:Animals; D055419:Bone Morphogenetic Protein 7; D052004:Bone Morphogenetic Protein Receptors; D052005:Bone Morphogenetic Protein Receptors, Type I; D019485:Bone Morphogenetic Proteins; D005910:Glioma / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D011506:Proteins / Q000032:analysis / Q000494:pharmacology; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000032:analysis*; D017978:Receptors, Growth Factor / Q000032:analysis; D016212:Transforming Growth Factor beta; D014407:Tumor Cells, Cultured
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D016212:Transforming Growth Factor beta; D029404:Activin Receptors; C498211:BMPR1A protein, human; C498214:BMPR1B protein, human; D052004:Bone Morphogenetic Protein Receptors; D052005:Bone Morphogenetic Protein Receptors, Type I