title: Mast cell tumour destruction in dogs by hypotonic solution.
abstract: Distilled water was studied as an hypoosmotic oncolysis agent to prevent mast cell tumour (MCT) recurrence following surgical excision. The results from 118 MCTs excised in 74 dogs were: surgery alone, a recurrence rate of 52.6 per cent (10/19); and surgery followed by distilled water injections into the wound, a 26.2 per cent (26/99) recurrence rate. All of 10 small MCTs (0.03 to 0.25 cm3) injected with distilled water in situ with no surgery, regressed. The present data suggest that distilled water should be considered as an adjunct to surgery for canine MCTs.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Grier
authors.forename: G
authors.initials: G
authors.lastname: Di Guardo
authors.forename: R
authors.initials: R
authors.lastname: Myers
authors.forename: D F
authors.initials: DF
authors.lastname: Merkley
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000517:prevention & control / Q000601:surgery / Q000628:therapy*; D004285:Dogs; D007038:Hypotonic Solutions / Q000008:administration & dosage; D007271:Injections, Intradermal / Q000662:veterinary; D015552:Injections, Intralesional / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D012515:Mast-Cell Sarcoma / Q000601:surgery / Q000628:therapy / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control / Q000662:veterinary*; D012878:Skin Neoplasms / Q000601:surgery / Q000628:therapy / Q000662:veterinary*; D014867:Water / Q000008:administration & dosage*
chemical_list: D007038:Hypotonic Solutions; D014867:Water