Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice.
The hypoglycemic and hypolipidemic effect of chitosan was investigated in normal and neonatal streptozotocin-induced diabetic (NSZ) mice, one of the animal models of lean type non-insulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia. Chitosan (5% food admixture) reduced the blood glucose (P < 0.01), cholesterol (P < 0.01) and triglyceride (P < 0.01) of normal mice after 4 weeks, and also significantly lowered the blood glucose (P < 0.05) and cholesterol (P < 0.05) of NSZ mice under the same conditions. But these parameters of KK-Ay mice, which exhibit obese type NIDDM with hyperinsulinaemia, were not affected by chitosan administration. It is concluded that chitosan would be useful for the treatment of lean type NIDDM with hypoinsulinaemia.
Miura
T
T
Suzuka University of Medical Science and Technology, Mie, Japan.
Usami
M
M
Tsuura
Y
Y
Ishida
H
H
Seino
Y
Y
D000818:Animals; D000831:Animals, Newborn; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics; D006946:Hyperinsulinism / Q000097:blood / Q000235:genetics; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009765:Obesity / Q000097:blood / Q000235:genetics; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D014280:Triglycerides; D002686:Chitin; D048271:Chitosan; D002784:Cholesterol