Cytotoxic benzyl dihydroflavonols from Cudrania tricuspidata.
Three new dihydroflavonols, gericudranins A-C were isolated from the stem bark of Cudrania tricuspidata. They were identified as 6,8-di-p-hydroxybenzyltaxifolin, 8-p-hydroxybenzyltaxifolin and 6-p-hydroxybenzyltaxifolin, respectively, by means of spectral studies. These compounds were cytotoxic to human tumor cell lines, such as CRL 1579 (skin), LOX-IMVI (skin), MOLT-4F (leukemia), KM12 (colon) and UO-31 (renal) in culture, with ED50 values of 2.7-31.3 micrograms ml-1.
Lee
I K
IK
Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.
Kim
C J
CJ
Song
K S
KS
Kim
H M
HM
Koshino
H
H
Uramoto
M
M
Yoo
I D
ID
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms; D006801:Humans; D007680:Kidney Neoplasms; D007938:Leukemia; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts; D018547:Plant Stems; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D012878:Skin Neoplasms; D014197:Trees; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C098271:gericudranin A; C098273:gericudranin C; C098272:gericudranin b; D011794:Quercetin