Close relationships between serotonergic and fibrinolytic systems revealed by a monoamine oxidase inhibitor treatment in rats.
In order to investigate a possible relationship between serotonergic and fibrinolytic systems, serotonin (5-hydroxytryptamine, 5-HT) metabolism was modified by the use of a monoamine oxidase inhibitor (tranylcypromine: 10 mg/kg body weight) and its effect on the fibrinolytic system was analyzed. Tranylcypromine caused a rise in whole blood 5-HT with a simultaneous fall in 5-hydroxyindoleacetic acid. Euglobulin clot lysis time was significantly prolonged 1 and 4 h after injection and tissue plasminogen activator (tPA) activity declined 4 h following administration with a simultaneous increase in its inhibitor (PAI) activity. Blood 5-HT was negatively related to tPA (r = -0.48; p < 0.05) and positively to PAI activities (r = 0.43; p < 0.05) in tranylcypromino-treated rats, whereas there were no such correlations in solvent-treated rats.
Urano
T
T
Department of Physiology, Hamamatus University School of Medicine, Shizuoka-ken, Japan.
Malyszko
J
J
Takada
Y
Y
Takada
A
A
D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood / Q000502:physiology*; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D014191:Tranylcypromine / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D014191:Tranylcypromine; D006897:Hydroxyindoleacetic Acid