title: Endoscopic features of Helicobacter pylori-related gastritis.
abstract: OBJECTIVE
  It is still controversial whether certain endoscopic features can be used to diagnose Helicobacter pylori (Hp)-related gastritis. To clarify this issue, we performed two consecutive prospective studies.
  
  
  METHODS
  In the first study, we tried to identify endoscopic criteria associated with Hp-related gastritis from a total of 66 predefined gastric features on endoscopy. These features were selected by a stepwise logistic regression analysis in 101 patients. The validity of these features gained from this first study was then evaluated in a second study in 86 patients (40 with Hp gastritis, 8 with Hp-unrelated gastritis and 38 with normal gastric mucosa).
  
  
  RESULTS
  Three features, namely an abnormal antral surface texture, a mammillated corpus surface, and white antral erosions, were identified in the first study as independent predictors of Hp-related gastritis. However, the sensitivity and specificity of these three criteria, as assessed in the second study, were only 75% and 63% respectively.
  
  
  CONCLUSIONS
  We conclude that it is not possible to diagnose Hp-related gastritis on the basis of the endoscopic appearance alone. The diagnosis should be based on other criteria, such as a rapid urease test, or a histological examination of gastric biopsies, or both.
authors.affiliation: Department of Internal Medicine, CHUV/PMU, Lausanne, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Bah
authors.forename: E
authors.initials: E
authors.lastname: Saraga
authors.forename: D
authors.initials: D
authors.lastname: Armstrong
authors.forename: D
authors.initials: D
authors.lastname: Vouillamoz
authors.forename: G
authors.initials: G
authors.lastname: Dorta
authors.forename: P
authors.initials: P
authors.lastname: Duroux
authors.forename: B
authors.initials: B
authors.lastname: Weber
authors.forename: F
authors.initials: F
authors.lastname: Froehlich
authors.forename: A L
authors.initials: AL
authors.lastname: Blum
authors.forename: J F
authors.initials: JF
authors.lastname: Schnegg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005756:Gastritis / Q000175:diagnosis* / Q000382:microbiology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity