title: Eosinophilic neuronal inclusions in the thalamus of ageing B6C3F1 mice.
abstract: The age-related incidence of thalamic neuronal inclusions in the brains of aged B6C3F1 mice and their histopathological and ultrastructural features were studied. Round to oval or rod-shaped eosinophilic inclusions, which were frequently observed in the neurons of the thalamic area, were stained positively with phosphotungstic acid haematoxylin. The inclusions were detected first at 32 weeks of age and the incidence and severity were higher in older animals, all of the mice being affected after 58 weeks of age. Ultrastructurally, the inclusions appeared as sheaves of parallel osmiophilic filaments in the perikaryon of the neurons in the thalamus. Thus thalamic neuronal inclusions in mice seem to be age-related, but their significance remains unclear.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.forename: T
authors.initials: T
authors.lastname: Masegi
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Kawada
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: K
authors.initials: K
authors.lastname: Yamazoe
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Goto
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D006824:Hybridization, Genetic; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000033:anatomy & histology*; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure*; D013788:Thalamus / Q000648:ultrastructure*