title: Onset timing of delayed complications and criteria of follow-up after operation for esophageal achalasia.
abstract: BACKGROUND
  The purpose of this study was to define the length of follow-up necessary to obtain definitive results of the Heller myotomy for the therapy of esophageal achalasia and the modalities of long-term follow-up. Insufficient myotomy, periesophageal scarring, and gastroesophageal reflux esophagitis are the most common late complications of operation for achalasia. Columnar-lined esophagus with or without dysplasia and cancer can further complicate postoperative reflux esophagitis. Because progressive worsening of results with time has been reported, we assessed the timing of appearance of these complications.
  
  
  METHODS
  Since 1973, 129 patients submitted to Heller myotomy were clinically and objectively followed up. Mean follow-up was 97.4 months (range, 12 to 268 months). Of 129 patients, 42 were followed up for less than 5 years (17 voluntary drop outs, 10 reoperations, 3 deaths, 12 in follow-up), 47 more than 5 years, 26 more than 10 years, 12 more than 15 years, and 2 more than 20 years. The timing of onset of symptoms and complications related to the myotomy were evaluated as was the development of dysplasia and cancer.
  
  
  RESULTS
  In 11 patients, severe dysphagia due to insufficient myotomy reappeared a mean of 12.4 months after the operation (range, 3 to 30 months). In 7 patients with periesophageal scarring, dysphagia recurred a mean of 18.8 months (range, 6 to 28 months) after the operation. Postoperative reflux esophagitis appeared in 22 patients a mean of 76.5 months (range 21 to 168 months) after the operation. Columnar-lined esophagus was detected in 8 patients a mean of 143.1 months (range, 85 to 230 months) after the operation. Mild to moderate dysplasia was found in 5 of 8 patients with columnar-lined esophagus a mean of 191.6 months after the operation (range, 152 to 287 months), and intramucosal adenocarcinoma was found in 1 patient with columnar-lined esophagus after 8 years.
  
  
  CONCLUSIONS
  Dysphagia secondary to insufficient myotomy and periesophageal scarring recurs early, not later than 3 years. Conversely, abnormal gastroesophageal reflux with related complications can appear more than 10 years postoperatively. Five years after the operation the follow-up should be primarily endoscopic and histologic. Results should withstand a follow-up of at least 10 years.
authors.affiliation: Department of Surgery, Intensive Care, and Organ Transplantation, University of Bologna, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Di Simone
authors.forename: V
authors.initials: V
authors.lastname: Felice
authors.forename: A
authors.initials: A
authors.lastname: D'Errico
authors.forename: F
authors.initials: F
authors.lastname: Bassi
authors.forename: F
authors.initials: F
authors.lastname: D'Ovidio
authors.forename: S
authors.initials: S
authors.lastname: Brusori
authors.forename: S
authors.initials: S
authors.lastname: Mattioli
mesh_terms: D000206:Actuarial Analysis; D002299:Cardia / Q000601:surgery; D003680:Deglutition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D003937:Diagnosis, Differential; D004931:Esophageal Achalasia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D004947:Esophagus / Q000601:surgery; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D006801:Humans; D007558:Italy / Q000453:epidemiology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D011446:Prospective Studies; D012008:Recurrence; D012086:Reoperation / Q000706:statistics & numerical data; D013997:Time Factors