title: Antimicrobial therapy in periodontics.
abstract: Cause-related therapy in periodontics is aimed at the reduction or elimination of microbial pathogens. Periodontitis is associated with microflorae which may consist of indigenous, exogenous or superinfecting organisms. In general, periodontal infections due to indigenous organisms (endogenous or commensal infections) are treated by continual reduction of the bacterial load, exogenous infections (true infections) by adjunctive antibiotic therapy and superinfections (opportunistic infections) by a combined approach of conventional therapy and improvement of compromising host or environmental factors. Properly selected single drug, combination drug and serial drug therapies show great promise in the treatment of severe periodontitis
authors.affiliation: Department of Periodontology, University of Southern California, School of Dentistry, Los Angeles, USA.
authors.forename: J
authors.initials: J
authors.lastname: Slots
authors.forename: A J
authors.initials: AJ
authors.lastname: van Winkelhoff
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D002985:Clinical Protocols; D003777:Dental Prophylaxis; D016503:Drug Delivery Systems; D004359:Drug Therapy, Combination; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D010347:Patient Care Planning; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology*; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology; D013754:Tetracyclines / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D008795:Metronidazole; D002939:Ciprofloxacin; D000658:Amoxicillin