Neuropsychopathological changes by organophosphorus compounds--a review.
1. Available literature dealing with neuropsychopathological changes after exposure to organophosphate insecticides is reviewed. 2. Subacute neurological sequelae following acute organophosphate intoxication include the 'intermediate syndrome', probably a myopathy elicited by excess acetylcholine, and the 'organophosphate-induced delayed neuropathy' (OPIDN), which is caused by particularly neurotoxic organophosphates that inhibit neuropathy target esterase. 3. Long-term toxic effects affecting behaviour as well as mental and visual functions are occasionally observed after exposure to high doses of organophosphates with repeated acute, clinically significant intoxications. 4. The available data do not indicate that asymptomatic exposure to organophosphates is connected with an increasing risk of delayed or permanent neuropsychopathological effects.
Eyer
P
P
Walther-Straub-Institut für Pharmakologie und Toxikologie, Universität München, Germany.
D002800:Cholinesterase Inhibitors / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D007306:Insecticides / Q000009:adverse effects*; D009420:Nervous System / Q000187:drug effects*; D009422:Nervous System Diseases / Q000139:chemically induced*; D009484:Neuropsychology; D009943:Organophosphorus Compounds; D012307:Risk Factors; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D004785:Environmental Pollutants; D007306:Insecticides; D009943:Organophosphorus Compounds