Abnormal sodium-lithium countertransport kinetics in immunoglobulin A nephropathy patients and the families: association with hypertension.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. There is an increased prevalence of hypertension, which is an important risk factor for progressive renal impairment, in patients with IgAN. Changes in sodium-lithium countertransport (Na/Li CT) kinetics, particularly high Vmax/Km, have been shown in familial essential hypertension. In this study a high Vmax/Km was observed in IgA probands with hypertension and/or progressive renal impairment. Mean blood pressure was higher in the first-degree relatives of patients with IgAN compared with relatives of normotensive IgAN probands. These hypertensive relatives had an increased Vmax/Vm ratio and a low Km of Na/Li CT. There is a strong correlation of Vmax/Vm (r = 0.82) between the IgA probands and their first degree relatives, suggesting strong familial factors contributing to this Na/Li CT kinetic parameter. An increased Vmax/Km ratio of Na/Li CT seems to be a better marker for familial hypertension than Km alone and may be useful in identifying those patients who are at a greater risk of developing hypertension.
Ho
K L
KL
Department of Medicine (Nephrology), University of Newcastle on Tyne, Freeman Hospital, United Kingdom.
Rutherford
P A
PA
Thomas
T H
TH
Wilkinson
R
R
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001706:Biopsy; D004359:Drug Therapy, Combination; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D006977:Hypertension, Renal / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D007668:Kidney / Q000473:pathology; D008094:Lithium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood*
D000959:Antihypertensive Agents; D008094:Lithium; D012964:Sodium