Self assembling nanostructures for sustained ophthalmic drug delivery.
Nanopseudolatex was prepared for sustained ophthalmic delivery. It was prepared by a solvent injection method without the use of any stabilizer. The acrylate copolymers Eudragit RLPM and RSPM were used as carrier materials. Their formation was confirmed by electron microscopy. The system was extensively characterized for particle size, viscosity, sedimentation volume, encapsulation efficiency, in vitro release profile and pharmacodynamic properties. The particle size was found to be stirring rate dependent above the injection rate of 1 ml/min. Only at slow stirring rates it was temperature dependent. There was no sedimentation for about 60 d. The viscosity was 23-27 cps which was particle size dependent. The results show an excellent encapsulation efficiency of about 94-98%. Release studies showed slow and consistent drug release from the formulation. However, Eudragit RSPM showed comparatively longer release than Eudragit RLPM nanosuspensions. Using this method we have developed a new formulation of diclofenac diethyl ammonium which showed increased therapeutic efficacy as compared with eye drops.
Khopade
A J
AJ
Department of Pharmaceutics, Bharati Vidyapeeth's Poona College of Pharmacy, Pune, India.
Jain
N K
NK
D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations / Q000009:adverse effects / Q000737:chemistry*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D004339:Drug Compounding; D008854:Microscopy, Electron; D008863:Microspheres; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000737:chemistry*; D010316:Particle Size; D011109:Polymethacrylic Acids; D011817:Rabbits; D013535:Suspensions; D014783:Viscosity
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D011109:Polymethacrylic Acids; D013535:Suspensions; D004008:Diclofenac; C038300:methylmethacrylate-methacrylic acid copolymer