title: Antibodies to human optic nerve in Leber's hereditary optic neuropathy.
abstract: Mutations of mitochondrial DNA have now been identified in the majority of patients with Leber's hereditary optic neuropathy (LHON). However, these mutations do not explain all the clinical features of LHON, and other pathogenetic factors are likely to be operating. We have analysed serum from 69 LHON patients and their relatives, 58 controls and 14 patients with ischemic or compressive optic neuropathy. A significant proportion of LHON patients had circulating antibodies to tubulin protein. This finding supports the theory that autoimmunity may play some role in the pathogenesis of LHON.
authors.affiliation: Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK.
authors.forename: P R
authors.initials: PR
authors.lastname: Smith
authors.forename: J M
authors.initials: JM
authors.lastname: Cooper
authors.forename: G G
authors.initials: GG
authors.lastname: Govan
authors.forename: P
authors.initials: P
authors.lastname: Riordan-Eva
authors.forename: A E
authors.initials: AE
authors.lastname: Harding
authors.forename: A H
authors.initials: AH
authors.lastname: Schapira
mesh_terms: D000328:Adult; D000941:Antigens / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D015551:Autoimmunity / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015151:Immunoblotting; D008297:Male; D015418:Optic Atrophies, Hereditary / Q000276:immunology*; D009900:Optic Nerve / Q000276:immunology*; D011233:Precipitin Tests; D014404:Tubulin / Q000276:immunology
chemical_list: D000941:Antigens; D001323:Autoantibodies; D014404:Tubulin