Beneficial effects of S-113m, a novel herbal prescription, on learning impairment model in mice.
The effects of S-113m, a novel herbal prescription consisting of Biota orientalis, Panax ginseng and Schisandra chinensis, were studied regarding learning and memory performance in the step-down and lever-press tests in normal, as well as in learning-impaired, mice. The prescription had no effect on memory registration, consolidation and retrieval processes or on motor activity in normal mice. However, a single oral administration of S-113m at doses of 250 and 500 mg/kg reduced the ethanol-induced and scopolamine-induced impairment of memory registration in the step-down test. The preparation also improved the electroconvulsive shock-induced impairment of memory consolidation in the same test. S-113m did not, however, attenuate the ethanol-induced impairment of memory retrieval. These suggest that S-113M has a preferential beneficial effect on the impairment of memory registration and memory consolidation rather than on memory retrieval in mice, through direct action on the learning and memory process.
Nishiyama
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N
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Wang
Y L
YL
Saito
H
H
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004597:Electroshock; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D018727:Muscarinic Antagonists; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal; D011597:Psychomotor Performance / Q000187:drug effects; D012601:Scopolamine
D004365:Drugs, Chinese Herbal; D018727:Muscarinic Antagonists; C098440:S 113m; D012601:Scopolamine