title: Regulation of beta-glucosidase biosynthesis in Aspergillus nidulans.
abstract: beta-Glucosidase in Aspergillus nidulans was found to be both intracellular and extracellular. The intracellular beta-glucosidase was synthesized after the exhaustion of carbon source in the medium. The extracellular enzyme appeared with autolysis of the mycelium. Biosynthesis of beta-glucosidase was not induced by various carbohydrates but repressed to varying extents in the presence of glucose, glycerol, and 2-deoxyglucose. This repression was not relieved by addition of cAMP. The repression was relieved much more by mutations in the creA gene than by one in the creC gene. Thus, beta-glucosidase synthesis in A. nidulans is subject to carbon catabolite repression.
authors.affiliation: Department of Microbiology, College of Natural Sciences, Seoul National University, South Korea. kskwon@geri4680.geri.re.kr.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: K S
authors.initials: KS
authors.lastname: Kwon
authors.forename: Y C
authors.initials: YC
authors.lastname: Hah
mesh_terms: D001233:Aspergillus nidulans / Q000201:enzymology* / Q000235:genetics; D002244:Carbon / Q000378:metabolism*; D004794:Enzyme Repression; D005798:Genes, Bacterial / Q000502:physiology*; D005947:Glucose / Q000502:physiology; D001617:beta-Glucosidase / Q000096:biosynthesis*
chemical_list: D002244:Carbon; D001617:beta-Glucosidase; D005947:Glucose