Effect of whole-body hyperthermia on AIDS patients with Kaposi's sarcoma: a pilot study.
The safety and possible efficacy of extracorporeal whole-body hyperthermia (WBHT) were evaluated in the first FDA-approved feasibility study of WBHT in persons with AIDS. Six gay men, aged 20-50 years, CDC class C-3, underwent 1 h of WBHT at either 40 degrees C or 42 degrees C, employing a system that minimizes the physiological and biochemical changes that occur during WBHT. All subjects had Kaposi's sarcoma (KS), were free of opportunistic infections, and had significant elevations of plasma HIV RNA. During the treatment, there were no adverse side effects and all subjects tolerated WBHT without problems. KS lesions partially regressed immediately following WBHT in all subjects but returned to pretreatment status in five of six patients at 1 week. In subjects treated at 40 degrees C, CD4 counts decreased during the 8-week follow-up period; they remained unchanged, however, following 42 degrees C WBHT. Viral load remained unchanged following WBHT in subjects treated at 40 degrees C. Treatment at 42 degrees C resulted in an immediate reduction in HIV RNA that was not sustained at 1 week post-WBHT. We conclude that WBHT is safe in subjects with advanced HIV disease and that it may have a role in treating HIV infection. A larger controlled trial involving two treatments in less immunocompromised subjects is currently in progress to test this hypothesis.
Steinhart
C R
CR
Mercy Special Immunology Services, Miami, Florida, USA.
Ash
S R
SR
Gingrich
C
C
Sapir
D
D
Keeling
G N
GN
Yatvin
M B
MB
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood; D005500:Follow-Up Studies; D016655:HIV Core Protein p24 / Q000097:blood; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012367:RNA, Viral / Q000097:blood; D012514:Sarcoma, Kaposi / Q000150:complications / Q000628:therapy*; D001613:beta 2-Microglobulin / Q000032:analysis
D004279:DNA, Viral; D016655:HIV Core Protein p24; D012367:RNA, Viral; D001613:beta 2-Microglobulin