Distribution of felbamate in brain.
We studied the distribution of felbamate (FBM) in rat brain using a br ain imaging scanner to analyze thaw-mount autoradiographs. After intravenous injection of 14 C FBM in rats, the autoradiograph distribution of isotope labeling patterns in brain was captured on x-ray film. Densitometric differences on the x-ray film were converted into color-code variations representing the different concentrations of FBM in regions of the brain. We demonstrated that relatively uniform concentrations of FBM were detected throughout the brain. In all brain regions examined, there were no specifically high or low concentrations of FBM. We conclude that the FBM distributes uniformly.
Cornford
E M
EM
West Los Angeles Veterans Administration Medical Center, California, USA.
Truong
H V
HV
Sofia
R D
RD
Kucharczyk
N
N
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D000078328:Felbamate; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution
D000927:Anticonvulsants; D002250:Carbon Radioisotopes; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate