The genetics of pain and pain inhibition.
The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, Poland; Portland, OR; and Los Angeles, which we feel demonstrates the continuing usefulness of classical genetic approaches, especially when used in combination with newly available molecular genetic techniques.
Mogil
J S
JS
Department of Psychology, University of California, Los Angeles, 90095-1563, USA.
Sternberg
W F
WF
Marek
P
P
Sadowski
B
B
Belknap
J K
JK
Liebeskind
J C
JC
D000698:Analgesia; D000818:Animals; D003433:Crosses, Genetic; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D006801:Humans; D015141:Los Angeles; D051379:Mice; D008815:Mice, Inbred Strains; D006899:Mixed Function Oxygenases / Q000235:genetics; D008957:Models, Genetic; D010146:Pain / Q000235:genetics* / Q000503:physiopathology* / Q000517:prevention & control; D010465:Perception; D017354:Point Mutation; D011044:Poland; D011995:Recombination, Genetic
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6