title: [A new oxa-analog of myristic acid, suppressing replication of the human immunodeficiency virus].
abstract: A series of oxaanalogs of myristic acid were synthesized and tested for antiviral activity in MT4 cells infected with human immunodeficiency virus 1 (HIV-1). The synthesized acids have no toxic effect on uninfected MT4 cells at a concentration of 100 microM. 14,14,14-Trifluoro-12-oxatetradecanoic acid substantially (by 75%) inhibits the reproduction of HIV-1. Other compounds synthesized, (7Z)-13-, (9Z)-13-, and (7Z)-11-oxatetradecenoic acids, exhibit no antiviral effect.
authors.forename: E L
authors.initials: EL
authors.lastname: Vodovozova
authors.forename: I I
authors.initials: II
authors.lastname: Mikhalev
authors.forename: A A
authors.initials: AA
authors.lastname: Rzhaninova
authors.forename: M M
authors.initials: MM
authors.lastname: Garaev
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Molotkovskiĭ
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D019814:Myristic Acid; D009227:Myristic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010100:Oxygen / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D009227:Myristic Acids; D019814:Myristic Acid; D010100:Oxygen