title: Investigation of mutagenicity of mineral trioxide aggregate and other commonly used root-end filling materials.
abstract: Little information is available regarding the mutagenicity of root-end filling materials. To study mutagenicity of Intermediate Restorative Material (IRM), Super-EBA, and a potential root-end filling material, mineral trioxide aggregate (MTA), strains of Salmonella typhimurium LT-2 (TA 98, R-factor strain and TA 1535, non-R-factor strains) were used in a standard Ames mutagenicity assay. Positive controls (S9 protein and benzo-(a)-pyrene and N-methyl-N'-nitro-N-nitrosoguanidine) operated properly. No increase in revertant bacteria colony counts occurred with any of the test materials. Based on these results, it seems that IRM, Super-EBA, and MTA are not mutagenic as measured by the Ames Test.
authors.affiliation: Department of Microbiology and Molecular Genetics, Schools of Medicine and Dentistry, Loma Linda University, California 92350, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Kettering
authors.forename: M
authors.initials: M
authors.lastname: Torabinejad
mesh_terms: D017607:Aluminum Compounds / Q000633:toxicity*; D017610:Calcium Compounds / Q000633:toxicity*; D015169:Colony Count, Microbial; D017220:Dentin-Bonding Agents / Q000633:toxicity; D004338:Drug Combinations; D008768:Methylmethacrylates / Q000633:toxicity; D009152:Mutagenicity Tests; D010087:Oxides / Q000633:toxicity*; D012184:Retrograde Obturation; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects; D017640:Silicates / Q000633:toxicity*; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D017220:Dentin-Bonding Agents; D004338:Drug Combinations; D008768:Methylmethacrylates; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement; C086631:mineral trioxide aggregate; C031667:IRM cement; C084074:Super EBA