title: A cholinesterase genes server (ESTHER): a database of cholinesterase-related sequences for multiple alignments, phylogenetic relationships, mutations and structural data retrieval.
abstract: We have built a database of sequences phylogenetically related to cholinesterases (ESTHER) for esterases, alpha/beta hydrolase enzymes and relatives). These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) with some related proteins devoid of enzymatic activity. The purpose of ESTHER is to help comparison and alignment of any new sequence appearing in the field, to favour mutation analysis of structure-function relationships and to allow structural data recovery. ESTHER is a World Wide Web server with the URL http://www.montpellier.inra.fr:70/cholinesterase.
authors.affiliation: Unité des Venins, Institut Pasteur, Paris, France.
authors.forename: X
authors.initials: X
authors.lastname: Cousin
authors.forename: T
authors.initials: T
authors.lastname: Hotelier
authors.forename: P
authors.initials: P
authors.lastname: Liévin
authors.forename: J P
authors.initials: JP
authors.lastname: Toutant
authors.forename: A
authors.initials: A
authors.lastname: Chatonnet
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016208:Databases, Factual; D004950:Esterases / Q000737:chemistry / Q000235:genetics*; D016247:Information Storage and Retrieval; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
chemical_list: D004950:Esterases