title: Development of a low cost microP-based blood gas monitor.
abstract: A low cost microprocessor-based system for continuous in-vivo measurement of blood pH and pCO2 using a biosensor is being developed. The biosensor is a pH Ti2O3 ISFET (Ion Sensitive Field Effect Transistor) with a sensitivity of -56 mV/pH and a linear response over physiologically meaningful blood pH range of 6.5 to 8.0. The ISFET chip is bonded onto a printed circuit board substrate to enable reliable and robust connections to three wires. The small sensor tip sized of 0.95 mm facilitates its incorporation into a catheter tip and its placement into a rat's artery. A microcontroller supervises preusage calibration, data logging, display of alphanumeric information on a LCD (liquid crystal display) unit, and resettable visual & audio alarm indicators. Preliminary clinical testing are underway to perfect the system and use it on a routine basis to monitor the physiological state of laboratory animals during neurophysiological experiments.
authors.affiliation: School of Engineering, Flinders University, Adelaide, SA.
authors.forename: H
authors.initials: H
authors.lastname: Nazeran
authors.forename: J D
authors.initials: JD
authors.lastname: Macrow
authors.forename: P
authors.initials: P
authors.lastname: Pilowski
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D015374:Biosensing Techniques; D001769:Blood / Q000378:metabolism; D001784:Blood Gas Analysis / Q000295:instrumentation*; D002245:Carbon Dioxide / Q000097:blood; D006863:Hydrogen-Ion Concentration; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D051381:Rats
chemical_list: D002245:Carbon Dioxide