title: Cerebral blood flow measured with intracerebral laser-Dopplerflow probes and radioactive microspheres.
abstract: We have measured cerebral blood flow with intracerebral laser-Doppler microprobes in pentobarbital-anesthetized pigs. We compared the results with measurements from laser-Doppler probes placed on the surface of the brain and with blood flow estimation by the radioactive microsphere method. The cerebral blood flow was varied by alterations in inspired carbon dioxide, hemorrhagic hypotension, and high cerebrospinal fluid pressure. The intracerebral probes and the surface probes showed parallel responses to variations in cerebral blood flow. The correlation was closest between surface probes and the intracerebral probes measuring from the cerebral cortex (r = 0.46; P < 0.005). The r value between laser-Doppler flowmetry and radioactive microspheres was 0.41 (P < 0.0005) for all measurements. The correlation to microspheres was best for the probes located 3 or 10 mm into the brain and poorest for the surface probe. In conclusion, intracerebral laser-Doppler flow measurements reflect changes in blood flow, and the technique appears useful for continuous estimates of cerebral blood flow.
authors.affiliation: Institute for Surgical Research, National Hospital, University of Oslo, Norway.
authors.forename: O J
authors.initials: OJ
authors.lastname: Kirkeby
authors.forename: I R
authors.initials: IR
authors.lastname: Rise
authors.forename: L
authors.initials: L
authors.lastname: Nordsletten
authors.forename: S
authors.initials: S
authors.lastname: Skjeldal
authors.forename: C
authors.initials: C
authors.lastname: Hall
authors.forename: C
authors.initials: C
authors.lastname: Risöe
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001784:Blood Gas Analysis; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006935:Hypercapnia / Q000503:physiopathology; D007022:Hypotension / Q000503:physiopathology; D007427:Intracranial Pressure; D017078:Laser-Doppler Flowmetry; D008297:Male; D008863:Microspheres; D013552:Swine