Anticoagulant effects of Pseudechis australis (Australian king brown snake) venom on human blood: a computerized thromboelastography study.
The crude venom of Pseudechis australis exhibited a dose-dependent anticoagulant action on human blood in vitro using computerized thromboelastography. Clot progress parameters (K and alpha) were affected at low dose levels which had no effect on onset of coagulation parameters (SP, R). At high dose levels there was total anticoagulant effect, but in all cases there was no evidence of fibrinolytic activity. These results generally agree with the known effects of this venom on coagulation in vivo, and further support our earlier suggestion that TEG may be a useful, one-step tool in the diagnosis and monitoring of the progress of envenomation patients.
Dambisya
Y M
YM
Department of Anaesthesia, National University of Singapore.
Lee
T L
TL
Gopalakrishnakone
P
P
D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012910:Snake Venoms / Q000008:administration & dosage / Q000494:pharmacology*; D013916:Thrombelastography
D000925:Anticoagulants; D012910:Snake Venoms