Developmental toxicity of dibasic esters by inhalation in the rat.
Dibasic esters (DBE) are a mixture of 3 carboxylic acid esters which are used in the paint and coatings industry. In this study, groups of pregnant Crl:CD BR rats were exposed to either 0.16, 0.4, or 1.0 mg DBE/L by inhalation for 6 hr/day from Days 7 through 16 of gestation (day in which copulation plug was detected was designated Day 1G). A control group of chambered pregnant rats was exposed simultaneously to air only. All female rats were euthanized on Day 21G and the fetuses were examined. A suppression of both food consumption and the rate of body weight gain was seen in the 0.4 and 1.0 mg/L groups during the first 6 exposure days. Staining on the fur and perineal area was seen in rats exposed to 1.0 mg/L and liver weight decreases, although not statistically significant, occurred in the 2 high exposure groups. None of the reproductive parameters were altered in any of the groups and no fetal effects were detected. DBE is not a developmental toxin in the rat following inhalation exposures as high as 1.0 mg DBE/L during the period of organogenesis.
Alvarez
L
L
E.I. DuPont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714, USA.
Driscoll
C
C
Kelly
D P
DP
Staples
R E
RE
Chromey
N C
NC
Kennedy
G L
GL
D000014:Abnormalities, Drug-Induced; D000272:Adipates / Q000008:administration & dosage / Q000633:toxicity; D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D005977:Glutarates / Q000008:administration & dosage / Q000633:toxicity; D008099:Liver / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D013386:Succinates / Q000008:administration & dosage / Q000633:toxicity
D000272:Adipates; D003998:Dicarboxylic Acids; D005977:Glutarates; D013386:Succinates; C067353:dimethyl glutarate; C029900:adipic acid; C056451:dimethyl succinate