Isochromosome 7q in adult Wilms' tumor.
We describe cytogenetic and histologic findings in a Wilms' tumor resected from a 37-year-old man. The tumor karyotype was 45,X,-Y,i(7)(q10). These findings are notable because overrepresentation of chromosome 7 long arm material, i(7)(q10) in particular, has been described recently as a nonrandom event in pediatric Wilms' tumors. The present case suggests a shared genetic pathway in the initiation or progression of some pediatric and adult Wilms' tumors.
Fletcher
J A
JA
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.
Renshaw
A A
AA
D000328:Adult; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D008297:Male; D009396:Wilms Tumor / Q000235:genetics* / Q000648:ultrastructure