title: A second double-stranded RNA virus from yeast.
abstract: Two double-stranded RNA viruses exist as permanent persistent infections of the yeast Saccharomyces cerevisiae: ScVL1 and ScVLa. Both belong to the Totiviridae, which include a number of fungal and protozoan double-stranded RNA viruses. Although ScVL1 and ScVLa share the same genomic organization and mode of expression and coexist in the same cells, they show no evidence of recombination: with one limited exception, sequence conservation is detectable only in regions conserved in all totiviruses. Both have two open reading frames on their single essential RNAs: cap (encoding a capsid polypeptide) and pol (encoding an RNA-dependent RNA polymerase). The ScVLa virus, like ScVL1, appears to express its Pol domain by a -1 translational frameshift.
authors.affiliation: Department of Biological Sciences, State University of New York at Buffalo, 14260, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Park
authors.forename: J D
authors.initials: JD
authors.lastname: Lopinski
authors.forename: J
authors.initials: J
authors.lastname: Masuda
authors.forename: T H
authors.initials: TH
authors.lastname: Tzeng
authors.forename: J A
authors.initials: JA
authors.lastname: Bruenn
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002213:Capsid / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012328:RNA Viruses / Q000235:genetics*; D012330:RNA, Double-Stranded / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000821:virology*
chemical_list: D004279:DNA, Viral; D012330:RNA, Double-Stranded