title: Blockade of the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382.
abstract: The present study was designed to assess the ability of the newly synthetized, selective gamma-hydroxybutyric acid (GHB) receptor antagonist, NCS-382, in blocking the discriminative stimulus effects of GHB in a T-maze, food-reinforced drug discrimination procedure. Two groups of rats were trained to run the left arm of the maze 30 min after the i.g. administration of either 300 or 700 mg/kg GHB and the right arm after water. Once discrimination was acquired, combination of different doses of NCS-382 (0, 12.5, 25.0 and 50.0 mg/kg, IP) and GHB training doses were tested for blockade of GHB discrimination. NCS-382 dose-dependently blocked GHB-appropriate responding in both the 300 and 700 mg/kg GHB rat groups. The results of the present study indicate that the discriminative stimulus properties of GHB are mediated via stimulation of GHB receptors.
authors.affiliation: Dipartimento di Neuroscienze "Bernard B. Brodie", Università di Cagliari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Colombo
authors.forename: R
authors.initials: R
authors.lastname: Agabio
authors.forename: J
authors.initials: J
authors.lastname: Bourguignon
authors.forename: F
authors.initials: F
authors.lastname: Fadda
authors.forename: C
authors.initials: C
authors.lastname: Lobina
authors.forename: M
authors.initials: M
authors.lastname: Maitre
authors.forename: R
authors.initials: R
authors.lastname: Reali
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001070:Appetitive Behavior / Q000187:drug effects*; D001567:Benzocycloheptenes / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D012978:Sodium Oxybate / Q000037:antagonists & inhibitors* / Q000494:pharmacology
chemical_list: C039403:4-hydroxybutyric acid receptor; D000927:Anticonvulsants; D001567:Benzocycloheptenes; D011956:Receptors, Cell Surface; C066471:NCS 382; D012978:Sodium Oxybate