title: Bioavailability of bropirimine 250 mg tablet in dogs: effect of food.
abstract: The postprandial effect on the bioavailability of bropirimine in dogs after oral administration of bropirimine tablets (Bropirimine 250 mg Tablet) was investigated. At a dose of 500 mg bropirimine (two tablets of bropirimine 250 mg), the maximum plasma concentration under the postprandial condition was about twice that observed under the fasting condition, and the area under the plasma concentration vs time curve under the postprandial condition was also twice that under the fasting condition. The absolute oral bioavailabilities of bropirimine were 41.1% under the fasting condition and 83.5% under the postprandial condition. It is considered that the longer gastric residence time and larger volume of the gastric fluid induced by food-intake caused the increase in dissolution of bropirimine which increased the bioavailability after oral dosing of bropirimine 250-mg tablets.
authors.affiliation: Upjohn Tsukuba Research Laboratories, Upjohn Pharmaceuticals Limited, Ibaraki, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Emori
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Yokohama
authors.forename: T
authors.initials: T
authors.lastname: Nishihata
mesh_terms: D000042:Absorption; D000276:Adjuvants, Immunologic / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D018592:Cross-Over Studies; D003596:Cytosine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005502:Food; D008297:Male; D013607:Tablets
chemical_list: D000276:Adjuvants, Immunologic; D013607:Tablets; D003596:Cytosine; C033560:bropirimine