title: The epidemiology of skin cancer.
abstract: BACKGROUND
  The incidence of skin cancer is increasing at an alarming rate.
  
  
  OBJECTIVE
  To discuss current epidemiologic data concerning the incidence, morbidity, environmental influences, predisposing, host conditions, precursor lesions, and prevention of melanoma and nonmelanoma (basal and squamous cell) skin cancer.
  
  
  METHODS
  The current literature was reviewed in order to provide current epidemiologic data for melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC).
  
  
  RESULTS
  Skin cancer is exceedingly common and the incidence is rising rapidly. Although the mortality rate for nonmelanoma skin cancer (NMSC) is decreasing, that of melanoma is increasing. Both NMSC and melanoma are associated with significant morbidity. Whereas chronic sun exposure is the main cause of NMSC, the development of melanoma appears to be related to intense, intermittent sun exposure. Ozone depletion has contributed to rising incidence rates of both NMSC and melanoma. In contrast to NMSC, there is not a direct relationship between ultraviolet radiation and melanoma. Genetic susceptibility significantly increases the lifetime risk of acquiring melanoma. There is no precursor lesion for BCC. Precursor lesions for invasive SCC include actinic keratoses and SCC in situ. Melanoma may arise from benign nevi and dysplastic nevi. Prevention of melanoma and NMSC is extremely important since prognosis improves with early detection. Prevention may be achieved by educating patients and physicians how to detect skin cancers early and by decreasing or eliminating exposure to ultraviolet light.
  
  
  CONCLUSIONS
  The incidence of skin cancer has reached epidemic proportions. Only through heroic efforts by health care professionals and the general public to prevent the development or progression of skin cancer will this epidemic be abated.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55095, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Gloster
authors.forename: D G
authors.initials: DG
authors.lastname: Brodland
mesh_terms: D004198:Disease Susceptibility; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D009017:Morbidity / Q000639:trends; D009026:Mortality / Q000639:trends; D011230:Precancerous Conditions / Q000453:epidemiology; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology