Dominant oncogenes, tumor suppressors, and radiosensitivity.
A variety of conflicting results appeared in the literature concerning the effect of dominant oncogenes on the sensitivity to irradiation and to anticancer agents in a number of cell lines of human and animal origin. In this report we provide evidence supporting the hypothesis that the tumor suppressor gene p53 and the apoptosis suppressor gene bcl2 modulate the effect of dominant oncogenes and that the effect of dominant oncogenes on resistance or sensitivity is dependent on the balance between the expression of p53 and bcl2.
Chiarugi
V
V
Laboratory of Molecular Biology, University of Firenze, Italy.
Magnelli
L
L
Cinelli
M
M
Turchetti
A
A
Ruggiero
M
M
D017209:Apoptosis / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004249:DNA Damage; D005799:Genes, Dominant; D016259:Genes, myc; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000528:radiation effects; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2; D011836:Radiation Tolerance / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53