title: Platelet size and left ventricular hypertrophy in hypertensive patients over 50 years of age.
abstract: Both mean platelet volume (MPV) and left ventricular hypertrophy have been described as associated with increased risk for vascular events. Seventy-six hypertensive patients (37 M and 39 F) over 50 years of age were studied. They were divided into subgroups according to the presence of left ventricular hypertrophy (LVH = LV mass index > 125 g m-2, when LV mass was assessed by M-mode echocardiography according to Penn's Convention). MPV was 3% higher in hypertensive patients with LVH compared with those without LVH (P > 0.05) and it was associated with the occurrence of LVH (chi-square = 8.44, P = 0.042). MPV significantly correlated with left ventricular mass index (r = 0.298, P = 0.004) and interventricular septum thickness (r = 0.231, P = 0.022). Both correlations remained significant after adjustment for age, blood pressure and glycaemia. MPV seemed to be associated with increased left ventricular mass and interventricular septum thickness in middle-aged to elderly hypertensive patients.
authors.affiliation: Cattedra Gerontologia e Geriatria, Universita' di Roma La Sapienza, Policlinico Umberto I, I Clinica Medica, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Scuteri
authors.forename: M
authors.initials: M
authors.lastname: Cacciafesta
authors.forename: A M
authors.initials: AM
authors.lastname: de Propris
authors.forename: M G
authors.initials: MG
authors.lastname: di Bernardo
authors.forename: D
authors.initials: D
authors.lastname: Recchi
authors.forename: V
authors.initials: V
authors.lastname: Celli
authors.forename: V
authors.initials: V
authors.lastname: Marigliano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000166:cytology*; D048429:Cell Size; D005260:Female; D006346:Heart Septum / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000473:pathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged