title: Fibrin glue for sealing the needle track in fine-needle percutaneous lung biopsy using a coaxial system: Part II--Clinical study.
abstract: OBJECTIVE
  Following percutaneous lung biopsy (PLB), we used fibrin glue as a sealant in 26 patients for the purpose of decreasing the incidence of pneumothorax.
  
  
  METHODS
  All 26 patients (group A) had chronic obstructive pulmonary disease (COPD). The results for group A were compared with a control group of 32 patients (group B), also with COPD and in whom fibrin glue was not used. All biopsies were conducted under computed tomography (CT) using a coaxial needle system consisting of 19-gauge and 22-gauge needles.
  
  
  RESULTS
  Pneumothorax developed in five patients (19.2%) in group A and in one instance, drainage was required (3.8%). In group B, pneumothorax developed in 13 patients (40.6%) and in six instances (18.8%) drainage was required. Comparing the use of chest-tube drainage in the two groups, a statistical significance was observed, p < 0.0025). No adverse reactions related to the fibrin glue were observed.
  
  
  CONCLUSIONS
  Our results indicate that fibrin glue is a safe sealing material for lung PLB and serves to decrease the incidence and, in particular, the severity of pneumothorax, especially in high-risk patients.
authors.affiliation: Department of Radiology, Regional University Hospital of Patras, Rion, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Petsas
authors.forename: D
authors.initials: D
authors.lastname: Siamblis
authors.forename: C
authors.initials: C
authors.lastname: Giannakenas
authors.forename: K
authors.initials: K
authors.lastname: Tepetes
authors.forename: D
authors.initials: D
authors.lastname: Dougenis
authors.forename: K
authors.initials: K
authors.lastname: Spiropoulos
authors.forename: I
authors.initials: I
authors.lastname: Fezoulis
authors.forename: I
authors.initials: I
authors.lastname: Dimopoulos
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008173:Lung Diseases, Obstructive / Q000473:pathology; D008297:Male; D011030:Pneumothorax / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives