[Neutron activation analysis of biological samples].
Multi-element analysis by neutron activation analysis (NAA) in respect to medical applications is discussed. Examples of trace element determinations in pathological human liver tissues, human serum, and rat liver are given. A very sensitive method for determining fluorinated drug in very small samples of human serum by neutron activation is also described. Each biological samples (ca. 100-200 mg, lyophilized matter) was irradiated for short time (10 s or 5 min.) and for long time (24 hrs) in Rikkyo University Research Reactor or Musashi Institute of Technology Research Reactor. Concentration of 12 elements (127I, 55Mn, 26Mn, 65Cu, 23Na, 41K, 37Cl, 27Al, 48Ca, 36S, 58Fe, 64Zn) in human pathological liver, Futraful (19F) (anti-cancer fluorinated drug) clearance of human serum, and calcium uptake (48Ca) in liver of rats were determined by NAA.
Ohta
A
A
Department of Radiology, Kitasato University School of Medicine.
Siraishi
F
F
Nagahara
T
T
Tomura
K
K
D000818:Animals; D006801:Humans; D008099:Liver / Q000737:chemistry; D008113:Liver Neoplasms / Q000737:chemistry; D009501:Neutron Activation Analysis; D051381:Rats; D014131:Trace Elements / Q000032:analysis*
D014131:Trace Elements