title: Treatment of native valve Candida endocarditis with fluconazole.
abstract: Candida endocarditis of native valves is difficult to diagnose and treat. The majority of cases require valve replacement and long term amphotericin treatment. We describe a case of Candida endocarditis which was successfully managed with fluconazole without valve replacement. The patient has now been reviewed for 4.5 years from the time of diagnosis and 39 months since treatment was discontinued.
authors.affiliation: Pharmacy Department, St George's Hospital, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Wells
authors.forename: G J
authors.initials: GJ
authors.lastname: Leech
authors.forename: A M
authors.initials: AM
authors.lastname: Lever
authors.forename: M H
authors.initials: MH
authors.lastname: Wansbrough-Jones
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D004696:Endocarditis / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008943:Mitral Valve / Q000382:microbiology; D012008:Recurrence; D013997:Time Factors; D014261:Tricuspid Valve / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole