"Bystander" damage of host muscle caused by implantation of MHC-compatible myogenic cells.
Transplantation of normal myoblasts has been considered a potential therapy for muscle dystrophies. While survival of implanted cells has been described in animal experiments and in human trials, functional effects remained unclear. Here we report on survival of progenors of implanted C2nlsBAG cells in regenerating muscles but irreversible net loss in muscle tissue and contractile force. This is caused by immune rejection of implanted myoblasts despite MHC-compatibility and "bystander" damage of host muscle tissue.
Wernig
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Department of Physiology, Neurophysiology, University of Bonn, Germany.
Irintchev
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D000818:Animals; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002470:Cell Survival / Q000502:physiology; D017690:Cell Transplantation / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D007537:Isometric Contraction / Q000502:physiology; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology / Q000637:transplantation*; D009929:Organ Size / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D001616:beta-Galactosidase / Q000096:biosynthesis
D015704:CD4 Antigens; D016827:CD8 Antigens; D001616:beta-Galactosidase