N(6) or N(9) substituted 2-phenyl-8-azaadenines: affinity for A1 adenosine receptors. VII.
The A1 activities shown respectively by N(6) or N(9) substituted 8-azaadenines were compared. At least in some cases, the biological results indicated the ability of the receptor to accept the exogenous molecule in various arrangements, and an attempt to rationalizing these arrangements was made by means of a model with two different molecular orientations.
Biagi
G
G
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Pisa.
Giorgi
I
I
Livi
O
O
Scartoni
V
V
Breschi
C
C
Martini
C
C
Scatizzi
R
R
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000241:Adenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D012756:Sheep; D013816:Thermodynamics; D014665:Vasodilator Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology
D001372:Aza Compounds; D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D000225:Adenine; D000241:Adenosine