title: Gamma Knife radiosurgery in AIDS-related primary central nervous system lymphoma.
abstract: The frequency of AIDS-associated primary central nervous system (PCNS) lymphoma is rapidly increasing in adults and children. In AIDS-related PCNS lymphoma, different authors have reported an overall poorer response rate to conventional radiation compared with immunocompetent patients. This poorer response consists of a significantly positive, although transient effect on survival following radiotherapy (XRT), with a poor toleration for prolonged whole-brain RT (WBR) and with radiation-induced changes within the normal CNS tissue on autopsy examinations after a course of XRT. These observations led us to consider highly focused single-session radiosurgical treatments as a potentially useful therapeutic modality for AIDS-associated PCNS lymphomas. A multi-institutional diagnostic and therapeutic protocol for the evaluation and treatment of AIDS patients with high-risk intracerebral space-occupying lesions has been developed at the University Hospital of Verona. Therapy is based on tumor biopsy. Tumors < or = 3.5 cm in diameter are subjected to Gamma Knife radiosurgery, whereas tumors < or = 4.5 cm are treated with stereotactic brachytherapy. At the Department of Neurosurgery, Verona, Italy, Gamma Knife treatment was performed in 2 cases of deep-seated histologically verified malignant non-Hodgkin's lymphoma. A short-term cliniconeuroradiological follow-up (2 months later) showed neurologic improvement and virtually complete disappearance of the tumor in both patients. The excellent local control and the well-tolerated single-session treatment and absence of brain toxicity signs on CT scan indicate a putative role for Gamma Knife radiosurgery in the treatment of these patients.
authors.affiliation: Department of Neurosurgery, University Hospital of Verona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Nicolato
authors.forename: M A
authors.initials: MA
authors.lastname: Gerosa
authors.forename: R
authors.initials: R
authors.lastname: Foroni
authors.forename: E
authors.initials: E
authors.lastname: Piovan
authors.forename: P G
authors.initials: PG
authors.lastname: Zampieri
authors.forename: A
authors.initials: A
authors.lastname: Pasoli
authors.forename: M G
authors.initials: MG
authors.lastname: Giri
authors.forename: P
authors.initials: P
authors.lastname: Iuzzolino
authors.forename: C
authors.initials: C
authors.lastname: Ghimenton
authors.forename: R
authors.initials: R
authors.lastname: Luzzati
mesh_terms: D000328:Adult; D016543:Central Nervous System Neoplasms / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000601:surgery*; D008297:Male; D016634:Radiosurgery; D016896:Treatment Outcome