[Effects of intrasubarachnoid space injection of anti dynorphin A1-13 serum or nor-BNI on the recovery of spinal cord injury in rats].
A pronounced and reversible spinal cord compression injury was performed by the compression of a metal plate 2.2mm x 5. Omm in size to the exposed spinal dura and loaded with 35g weight for 5 minutes at T7-8. Anti dynorphin serum at 10 microliters (1:30000) or kappa antagonist nor-BNI at 100 ng was administered intrasubarachnoidly shortly after the injury, with half dose applied 1, 2, 3 h after the injury for another three times. The recovery of neurological function was investigated. The results showed that the recovery of the muscle tension and motor function of the hindlimb in anti dynorphin serum group is markedly faster than that in both control and nor-BNI groups. Also the recovery of motor function in nor-BNI group is favourable at the earlier stage of injury, comparing to the control group. There were no significant differences in the change of mean arterial pressure and blood physiological parameters among the three groups.
Hong
X
X
Department of Neurobiology, Second Mailitary Medical University, Shanghai.
Li
B
B
Li
M
M
D000818:Animals; D004399:Dynorphins / Q000276:immunology*; D007106:Immune Sera; D066298:In Vitro Techniques; D007278:Injections, Spinal; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors; D013119:Spinal Cord Injuries / Q000628:therapy*
D007106:Immune Sera; D009292:Narcotic Antagonists; D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; C051844:norbinaltorphimine; D009271:Naltrexone; C026843:dynorphin (1-13); D004399:Dynorphins