title: Sporadic acute lymphocytic leukemia arising in a patient with neurofibromatosis and xanthogranulomatosis.
abstract: We present a case report of a child who developed acute lymphoblastic leukemia, neurofibromatosis, optic glioma, and xanthogranulomatosis. This complex is unusual, not previously described, and appears to be a coincidence of different diseases. The importance of this case is that it may offer a clue to the genetic base of neurofibrosis syndromes including leukemic associations.
authors.affiliation: Division of Pediatric Oncology, Ospedale Bambino Gesu, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Deb
authors.forename: D
authors.initials: D
authors.lastname: Habetswallner
authors.forename: L
authors.initials: L
authors.lastname: Helson
authors.forename: L
authors.initials: L
authors.lastname: De Sio
authors.forename: M
authors.initials: M
authors.lastname: Caniglia
authors.forename: A
authors.initials: A
authors.lastname: Donfrancesco
mesh_terms: D005910:Glioma / Q000150:complications; D006801:Humans; D007223:Infant; D008297:Male; D017253:Neurofibromatoses / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*; D012878:Skin Neoplasms / Q000150:complications; D014972:Xanthogranuloma, Juvenile / Q000150:complications*