Synthesis and characterization of iodixanol.
Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.
Priebe
H
H
Research and Development, Nycomed Imaging AS, Oslo, Norway.
Dugstad
H
H
Gacek
M
M
Hagen
E
E
Homestad
O M
OM
Larsen
A
A
Sjogren
C E
CE
Thomassen
T
T
D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D014283:Triiodobenzoic Acids / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol