[Chronobiology and chronopharmacology of cardiovascular diseases].
Physiological functions as well as pathophysiological events--angina pectoris, myocardial infarction, sudden cardiac death--display pronounced circadian rhythms. Clinical studies also give evidence for a circadian phase dependency in the pharmacokinetics of cardio-vascular active drugs. Thus, a circadian phase dependency in the dose-response relationship of drugs has to be taken into account.
Lemmer
B
B
Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim, Ruprecht-Karls-Universität, Heidelberg, Deutschland.
D000818:Animals; D001682:Biological Availability; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology*; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology*; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats
D002317:Cardiovascular Agents