Uterine Doppler wave form and the prediction of the recurrence of pre-eclampsia and intra-uterine growth retardation in patients treated with low-dose aspirin.
OBJECTIVE
To examine if early uterine Doppler remains a predictor of vascular complications in pregnant women treated with low-dose aspirin for a poor previous obstetrical history.


METHODS
A study of the uterine diastolic index and the uterine notch with a continuous wave Doppler ultrasound.


METHODS
The maternity Hospital Port-Royal Baudelocque Paris, France.


METHODS
All pregnant women between 1991-1992 (n = 48) early treated with 100 mg daily of aspirin (15.9 (S.D. = 1) weeks) for a poor previous obstetrical history.


METHODS
The 48 patients underwent a uterine Doppler examination at 23.8 (S.D. = 2.6) weeks. A diastolic index was calculated and the presence of diastolic notch was noted.


METHODS
Vascular complications (pre-eclampsia, intra-uterine growth retardation), birth weight.


RESULTS
Twenty six patients (54.2%) had an abnormal early uterine Doppler. Nine patients (18.7%) had a vascular complication, which occurred more frequently in pregnant patients with an abnormal uterine Doppler (8/26 vs. 1/22; P < 0.05). The mean birth weight was lower in patients with a pathological uterine Doppler (2419 (S.D. = 679) vs. 2841 (S.D. = 482) g; P < 0.05).


CONCLUSIONS
In pregnant, early treated with low-dose aspirin for poor previous pregnancies, early uterine Doppler predicted patients with a high-risk of recurrence of vascular complications.
Haddad
B
B
Department of Obstetrics, Clinique Universitaire Baudelocque-Port Royal, Hôpital Cochin, Paris, France.
Uzan
M
M
Bréart
G
G
Uzan
S
S
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging* / Q000517:prevention & control; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal
D001241:Aspirin