Beta-amyloid (1-42) affects cholinergic but not parvalbumin-containing neurons in the septal complex of the rat.
beta-Amyloid(1-42) peptide (beta AP(1-42) was injected into the medial septum of rats. After a 14-day survival time, neuronal alterations in the septal cholinergic and GABAergic systems were visualized by means of histo- and immunocytochemical methods. Neurons insulted by the peptide were primary choline acetyltransferase-immunoreactive (ir), while only minor effects of beta AP(1-42) were observed on parvalbumin-ir interneurons. These results indicate that the changes in intracellular Ca2+ level elicited by beta AP(1-42) may contribute to beta-amyloid neurotoxicity, and Ca(2+)-binding proteins may play an important role in the protection against the neurotoxic effects of beta AP(1-42).
Harkany
T
T
Department of Zoology and Cell Biology, Attila József University, Szeged, Hungary.
De Jong
G I
GI
Soós
K
K
Penke
B
B
Luiten
P G
PG
Gulya
K
K
D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D006651:Histocytochemistry; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects*; D010320:Parvalbumins / Q000032:analysis*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012688:Septum Pellucidum / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*
D016229:Amyloid beta-Peptides; D010320:Parvalbumins; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D002795:Choline O-Acetyltransferase