Nitric oxide and cyclic GMP signaling.
NO and cGMP constitute an autocrine, paracrine, and possible endocrine signal transduction system. Cytosolic NO-responsive guanylyl cyclase can be stimulated by NO derived from its own cell, from similar or distinct neighboring cell types within a tissue, from a circulating pool of NO (as NO+ equivalents coupled to plasma protein thiol groups), or from pharmacologic agents, the nitrovasodilators. NO and cGMP together comprise an especially wide-ranging signal transduction system when one considers (i) the many roles of cGMP in physiological regulation, including smooth muscle relaxation, visual transduction, intestinal ion transport, and platelet function; (ii) the many sources, biochemical interactions, and functions of NO; and (iii) the interactions of cGMP and its affected pathways with other signaling systems such as phosphoinositides, eicosanoids, cAMP and Ca2+.
McDonald
L J
LJ
Molecular Geriatrics Corporation, Lake Bluff, Illinois 60044, USA.
Murad
F
F
D000818:Animals; D006152:Cyclic GMP / Q000502:physiology*; D006162:Guanylate Cyclase / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000502:physiology; D010716:Phosphatidylinositols / Q000378:metabolism
D010716:Phosphatidylinositols; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase; D006152:Cyclic GMP