title: Effects of stress on neurotrophic factor expression in the rat brain.
abstract: Changes in neurotrophic factor expression in the brain are part of the stress response. Decreased BDNF may contribute to hippocampal damage that occurs during chronic stress or aging. Stress-induced increases in NT-3 may be important for neural plasticity and adaptation or sensitization to repeated stress. Stress-induced changes in neurotrophic factors may be particularly relevant to the cognitive changes that occur in recurrent depression, aging, and posttraumatic stress disorder.
authors.affiliation: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: R
authors.initials: R
authors.lastname: Kvetnanský
authors.forename: R M
authors.initials: RM
authors.lastname: Post
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor; D018891:Dentate Gyrus / Q000378:metabolism; D005938:Glucocorticoids / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020933:Neurotrophin 3; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005938:Glucocorticoids; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3