title: Cirrhosis of the liver: MR imaging with mangafodipir trisodium (Mn-DPDP).
abstract: OBJECTIVE
  To evaluate the usefulness of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (Mn-DPDP) in magnetic resonance (MR) imaging of cirrhotic livers.
  
  
  METHODS
  Fifty-eight patients (mean age, 58.8 years), 29 with and 29 without cirrhosis, underwent MR imaging before and after intravenous administration of 5 mumol/kg Mn-DPDP. Enhancement effects were assessed quantitatively and qualitatively. Histologic confirmation was obtained in 51 patients.
  
  
  RESULTS
  Liver parenchyma in both patient groups enhanced significantly on T1-weighted spin-echo and gradient-recalled-echo (GRE) images (P < .01). However, cirrhotic livers enhanced significantly less than noncirrhotic livers on T1-weighted GRE images (P < .05). Fourteen cirrhotic livers had heterogeneous enhancement of parenchyma; enhancement was more prominent on GRE images. Decreased enhancement was seen in patients with confluent fibrosis (n = 5), diffuse fibrosis (n = 6), and siderotic regenerating nodules (n = 4). Increased enhancement was seen in patients with benign regenerating nodules (n = 4).
  
  
  CONCLUSIONS
  Mn-DPDP is useful in patients with cirrhosis.
authors.affiliation: Department of Radiology, University of Pittsburgh Medical Center, PA 15213-2582, USA.
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: R L
authors.initials: RL
authors.lastname: Baron
authors.forename: M P
authors.initials: MP
authors.lastname: Federle
authors.forename: M S
authors.initials: MS
authors.lastname: Peterson
authors.forename: J H
authors.initials: JH
authors.lastname: Oliver
authors.forename: P L
authors.initials: PL
authors.lastname: Davis
authors.forename: S R
authors.initials: SR
authors.lastname: Confer
mesh_terms: D016022:Case-Control Studies; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid