title: Efficacy of gentian violet in the eradication of methicillin-resistant Staphylococcus aureus from skin lesions.
abstract: The efficacy of gentian violet (Gv) in eradicating methicillin-resistant Staphylococcus aureus (MRSA) in decubitus ulcers was investigated. Decubitus ulcers (a total of 18 cases) were scrubbed with Gv aqueous solution 0.1% and ointment containing Gv 0.1% was applied daily. MRSA was not detected in these lesions for 3-34 days (average, 10.5 +/- 2.5 days) after the application of Gv ointment. Before this trial, all patients were treated with povidone-iodine and antibiotics; however, those treatments were not effective in eradicating MRSA from skin lesions. Skin irritation and other systemic side effects caused by Gv were not observed. Our data suggest that Gv is a useful agent for treatment of the decubitus ulcers infected with MRSA.
authors.affiliation: Section of Pharmaceutics, First Hospital of Nippon Medical School, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Saji
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Uchiyama
authors.forename: E
authors.initials: E
authors.lastname: Osono
authors.forename: N
authors.initials: N
authors.lastname: Hayama
authors.forename: H
authors.initials: H
authors.lastname: Ohkuni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D005260:Female; D005840:Gentian Violet / Q000494:pharmacology*; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009824:Ointments; D003668:Pressure Ulcer / Q000382:microbiology*; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000891:Anti-Infective Agents, Local; D009824:Ointments; D012996:Solutions; D005840:Gentian Violet