title: Cardiac release of histamine after ventricular fibrillation and defibrillation during insertion of implantable cardioverter defibrillators (ICD).
abstract: Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5 min after DEF (18-24 Joules). Basal arterial histamine was 2.5 +/- 6 nmol/l, and did not increase after VF. The histamine level in CS was 1.1 +/- 0.2 nmol/l before VF (p < 0.008 compared to arterial), and increased to 2.5 +/- 0.6 nmol/l immediately after (p < 0.045 compared to basal), to 3 +/- 1.1 nmol/l 2 min after (p < 0.45), and to 2.4 +/- 0.8 nmol/l 5 min after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in coronary venous blood, suggesting cardiac release of histamine.
authors.affiliation: Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Valen
authors.forename: M
authors.initials: M
authors.lastname: Runsiö
authors.forename: A
authors.initials: A
authors.lastname: Owall
authors.forename: J
authors.initials: J
authors.lastname: Kaszaki
authors.forename: S
authors.initials: S
authors.lastname: Nagy
authors.forename: M
authors.initials: M
authors.lastname: Rosenqvist
authors.forename: L
authors.initials: L
authors.lastname: Bergfeldt
authors.forename: J
authors.initials: J
authors.lastname: Vaage
mesh_terms: D000368:Aged; D001794:Blood Pressure; D003326:Coronary Circulation; D017147:Defibrillators, Implantable; D005260:Female; D006636:Histamine Release; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D014693:Ventricular Fibrillation / Q000378:metabolism* / Q000628:therapy