Expression of c-fos protein in substance P receptor-like immunoreactive neurons in response to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord segments of the rat.
Chemical irritation of the urinary bladder with formalin in the rat induced c-fos protein-like immunoreactivity in more than 80% of substance P receptor-like immunoreactive (SPR-LI) neurons of the dorsal commissural nucleus, sacral parasympathetic nucleus and lamina I in the 6th lumbar and 1st sacral cord segments. These neurons with SPR-LI may receive noxious information from the urinary bladder through the primary afferent fibers with substance P.
Lü
Y
Y
Department of Anatomy, Fourth Military Medical University, Xi'an, People's Republic of China.
Jin
S X
SX
Xu
T L
TL
Qin
B Z
BZ
Li
J S
JS
Ding
Y Q
YQ
Shigemoto
R
R
Mizuno
N
N
D000818:Animals; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007509:Irritants / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000294:innervation* / Q000378:metabolism
D007509:Irritants; D016760:Proto-Oncogene Proteins c-fos; D018040:Receptors, Neurokinin-1; D005557:Formaldehyde