[Status of enzymatic lipid peroxidation in the heart of young and old rats under stress].
The present investigation reveals increase of diene conjugate accumulation, decrease of the level of TBA-positively reacting substances and the constant concentrations of Schiff's bases in the incubation medium during the stimulation of NADPH-dependent lipid peroxidation in the heart homogenates of stressed rats as compared with native animals. The intensity of diene conjugate accumulation and the decrease of thiobarbiturate-reacting substances were less expressed in the aged rats than in young ones. It is supposed that stress in the aged rats in accompanied by the decreased effectiveness of initiation processes of free radical reactions and the emergence of certain specific features of conversion of myocardial lipid peroxidation intermediates during stress.
Svets
V N
VN
Davydov
V V
VV
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005609:Free Radicals; D007103:Immobilization; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012545:Schiff Bases / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D013858:Thiobarbiturates / Q000378:metabolism
D005609:Free Radicals; D012545:Schiff Bases; D013858:Thiobarbiturates; D009249:NADP; C029684:thiobarbituric acid