[Medichronal lowers blood ethanol and acetaldehyde and restores the concentration of catecholamines in rat tissues].
Variation of ethanol and acetaldehyde concentrations in blood, catecholamines in hypothalamus, brain stem and hemispheres, heart and adrenal glands, serotonin in the same structures of the brain, thin intestine and blood in rats was studied. Isolated action of medichronal during 10 days against the background of prolonged administration of moderate doses of ethanol significantly lowered ethanol and acetaldehyde concentration in the animal blood. Medichronal increased the level of noradrenaline, lowered under the conditions of ethanol intoxication in the hypothalamus, and increased adrenalina level in the heart; noradrenaline level in adrenal glands is restored. The amount of serotonin in the blood and tissues increased under the conditions of ethanol intoxication did not vary under the action of medichronal. The obtained results indicate to pronounced detoxication influence of medichronal. One of the mechanisms of its action is normalizing the catecholamine changes caused by the ethanol intoxication in tissues.
Bozhko HKZh
Boĭko
T P
TP
Kostiukovs'ka
L S
LS
D000079:Acetaldehyde / Q000097:blood*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000427:Alcohol Deterrents / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004338:Drug Combinations; D000431:Ethanol / Q000097:blood*; D005561:Formates / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D000427:Alcohol Deterrents; D002395:Catecholamines; D004338:Drug Combinations; D005561:Formates; C088648:medikhronal; D012701:Serotonin; D000431:Ethanol; D000079:Acetaldehyde; D005947:Glucose; D005998:Glycine