title: Catalysis of guanine nucleotide exchange of Ran by RCC1 and stimulation of hydrolysis of Ran-bound GTP by Ran-GAP1.
authors.affiliation: Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany.
authors.forename: F R
authors.initials: FR
authors.lastname: Bischoff
authors.forename: H
authors.initials: H
authors.lastname: Ponstingl
mesh_terms: D018797:Cell Cycle Proteins; D002845:Chromatography / Q000379:methods; D002850:Chromatography, Gel / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D003001:Cloning, Molecular / Q000379:methods; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D017886:Durapatite; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D004926:Escherichia coli; D019204:GTP-Binding Proteins / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D006150:Guanine Nucleotides / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D006868:Hydrolysis; D015151:Immunoblotting; D007700:Kinetics; D009687:Nuclear Proteins / Q000302:isolation & purification / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D011506:Proteins / Q000302:isolation & purification / Q000378:metabolism*; D011865:Radioisotope Dilution Technique; D011994:Recombinant Proteins / Q000302:isolation & purification / Q000378:metabolism; D014316:Tritium; D020931:ran GTP-Binding Protein
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D006150:Guanine Nucleotides; D009687:Nuclear Proteins; D010761:Phosphorus Radioisotopes; D011506:Proteins; C062521:RCC1 protein, human; D011994:Recombinant Proteins; D014316:Tritium; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D017886:Durapatite; D019204:GTP-Binding Proteins; D020931:ran GTP-Binding Protein