Structural studies of vinblastine alkaloids by exciton coupled circular dichroism.
SCF-CI-dipole velocity MO calculations have shown that the bisignate circular dichroic curves of vinblastine/vincristine alkaloids at ca 210 and 220-230 nm are due to exciton coupling between the indoline and indole moieties. Furthermore, a combination of X-ray crystal structure data with MM2 local energy minimization provides a convenient means for estimation of the preferred solution conformation.
Dong
J G
JG
Department of Chemistry, Columbia University, New York, NY 10027, USA.
Bornmann
W
W
Nakanishi
K
K
Berova
N
N
D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013053:Spectrophotometry; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000737:chemistry*; D014748:Vinca Alkaloids / Q000737:chemistry*; D014750:Vincristine / Q000737:chemistry
D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine