Toxicity of field bindweed (Convolvulus arvensis) to mice.
The effects of feeding high and low doses of field bindweed (Convolvulus arvensis) to mice were investigated. Bindweed contains several alkaloids, including pseudotropine, and lesser amounts of tropine, tropinone, and meso-cuscohygrine. Mice fed bindweed exclusively died or were euthanized after 4-7 d and had severe hepatic necrosis and gastritis with ulceration or erosions. Mice fed low doses of bindweed along with standard laboratory mouse diet for 6 or 8 w had no clinical disease or gross lesions on necropsy examination but did have histologic lesions of mild multifocal hepatitis and gastritis.
Schultheiss
P C
PC
Department of Pathology, Colorado State University, Fort Collins 80523, USA.
Knight
A P
AP
Traub-Dargatz
J L
JL
Todd
F G
FG
Stermitz
F R
FR
D000096:Acetone / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005756:Gastritis / Q000139:chemically induced; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced; D051379:Mice; D010939:Plant Poisoning / Q000503:physiopathology; D010947:Plants, Toxic; D011759:Pyrrolidines / Q000633:toxicity*; D013276:Stomach Ulcer / Q000139:chemically induced; D014326:Tropanes / Q000633:toxicity*
D011759:Pyrrolidines; D014326:Tropanes; D000096:Acetone; C016808:3-tropinone; C005864:tropine; C098327:cuscohygrine