Comparison of volume output from two different continuous nebulizer systems.
BACKGROUND
Continuous nebulization is a safe and practical method of administration of beta 2-adrenergic agonists during acute asthma. There are essentially two types of continuous nebulizer systems; one utilizes a large volume nebulizer and the other a small volume nebulizer attached to a constant volume infusion pump.


OBJECTIVE
We compared the volume output characteristics of these two systems.


METHODS
Study performed at Danbury Hospital. Both types of continuous nebulizers were reconstructed as reported in the literature and output monitored hourly for four hours. A total of nine nebulizers from each type of continuous nebulizer was evaluated, three from each of three different lots.


RESULTS
The volume output of the large volume nebulizer ranged from 37.7 to 55.4 mL/h with a mean of 45.96 mL/h (P = .0001). Contrasts within the repeated measure ANOVA revealed that all pairwise contrasts in time were significant (P < .05) except for the 60 and 120 minute means. The volume output of the small volume nebulizer ranged from 15.0 to 16.6 mL/h with a mean of 15.88 mL/h. There was a significant difference in the mean volume output across time for the 60-minute value only. No other significant differences were found.


CONCLUSIONS
These data suggest that the small volume nebulizer utilized in this manner for continuous nebulization is a more consistent delivery device than the large volume nebulizer. Further data are required on both actual drug output and mass median aerodynamic diameter of the particles generated by these nebulizers before one can recommend a particular system.
Reisner
C
C
Danbury Hospital, Connecticut, USA.
Lee
J
J
Kotch
A
A
Dworkin
G
G
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000704:Analysis of Variance; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems / Q000706:statistics & numerical data; D007260:Infusion Pumps / Q000706:statistics & numerical data; D009330:Nebulizers and Vaporizers / Q000706:statistics & numerical data
D000318:Adrenergic beta-Agonists; D018927:Anti-Asthmatic Agents