Phospholipases A2 in the serum of patients after coronary artery bypass surgery.
OBJECTIVE
To study the catalytic activity of phospholipase A2 and the concentrations of group I and group II phospholipase A2 in the sera of patients during and after coronary artery bypass surgery.


METHODS
Prospective study.


METHODS
University hospital and research laboratory.


METHODS
Fourteen consecutive patients operated on for ischemic heart disease.


METHODS
The catalytic activity of phospholipase A2 and the serum concentrations of group I and group II phospholipases A2 were measured before, during, and after the operation until the seventh postoperative day. A total of 196 blood samples were taken from 14 patients.


RESULTS
The catalytic activity of phospholipase A2 and the concentration of group II phospholipase A2 increased in the sera of patients after coronary artery bypass surgery. The concentration of Group I phospholipase A2 did not change. The catalytic activity of phospholipase A2 correlated significantly with group II but not with group I phospholipase A2 values.


CONCLUSIONS
The increase in the catalytic activity of phospholipase A2 in serum after coronary artery bypass surgery is due to group II phospholipase A2. The present results suggest that group II phospholipase A2 is responsible for the physiologic and pathophysiologic effects of catalytically active phospholipase A2 after coronary artery bypass surgery.
Grönroos
J M
JM
Department of Surgery, University of Turku, Finland.
Kuttila
K
K
Perttilä
J
J
Nevalainen
T J
TJ
D000328:Adult; D000368:Aged; D002384:Catalysis; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood / Q000201:enzymology* / Q000276:immunology / Q000601:surgery*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood* / Q000145:classification / Q000276:immunology; D054467:Phospholipases A2; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors
D010741:Phospholipases A; D054467:Phospholipases A2