Dehydroepiandrosterone enhances influenza immunization in aged mice.
The effect of DHEA administration on the age-associated decline in immunity against influenza vaccine was studied. Increased humoral response was observed in 16- and 24-month-old mice immunized by live A/PR/8/34 (H1N1) influenza virus following DHEA treatment (a single injection adjacent to immunization). Furthermore, DHEA-treated mice demonstrated increased resistance to postvaccination intranasal challenge with live influenza virus. Thus, DHEA treatment overcomes the age-related defect in the immunity of old mice against influenza.
Danenberg
H D
HD
Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Ben-Yehuda
A
A
Zakay-Rones
Z
Z
Friedman
G
G
D000375:Aging; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D005260:Female; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000517:prevention & control
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D003687:Dehydroepiandrosterone