title: Clinical histopathological characteristics of basal cell carcinoma in Japanese patients.
abstract: BACKGROUND
  Basal cell carcinoma (BCC) does not commonly occur in the African and Asian races. Thus, there have been few reviews that have described the clinical overview of BCC among Japanese patients. There have been no large-scale analyses, including the histopathological features of BCC, except for the white race. We retrospectively examined 243 Japanese patients with BCC and analyzed the color of the tumors, the patient's age at which these tumors occurred, the site of the lesions, the histopathological patterns, and the incidence of recurrence and metastasis of the tumors; we compared these features with those in the other races statistically.
  
  
  METHODS
  Clinically, approximately 75% of the tumors were pigmented and showed a so-called black pearly appearance. The male-female ratio was 0.97, and the average age of the patients was 59 years. Seventy-five percent of the tumors occurred on the head and neck. Fifty-four percent of the tumors showed a solid type of histopathological pattern. The incidence of recurrence and metastasis is extremely rare.
  
  
  CONCLUSIONS
  The high incidence of hyperpigmentation in the lesional skin of BCC is the most characteristic feature of BCCs in Japanese patients.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000208:ethnology / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012744:Sex Ratio; D012878:Skin Neoplasms / Q000208:ethnology / Q000473:pathology