Efficacy of gentian violet in the eradication of methicillin-resistant Staphylococcus aureus from skin lesions.
The efficacy of gentian violet (Gv) in eradicating methicillin-resistant Staphylococcus aureus (MRSA) in decubitus ulcers was investigated. Decubitus ulcers (a total of 18 cases) were scrubbed with Gv aqueous solution 0.1% and ointment containing Gv 0.1% was applied daily. MRSA was not detected in these lesions for 3-34 days (average, 10.5 +/- 2.5 days) after the application of Gv ointment. Before this trial, all patients were treated with povidone-iodine and antibiotics; however, those treatments were not effective in eradicating MRSA from skin lesions. Skin irritation and other systemic side effects caused by Gv were not observed. Our data suggest that Gv is a useful agent for treatment of the decubitus ulcers infected with MRSA.
Saji
M
M
Section of Pharmaceutics, First Hospital of Nippon Medical School, Tokyo, Japan.
Taguchi
S
S
Uchiyama
K
K
Osono
E
E
Hayama
N
N
Ohkuni
H
H
D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D005260:Female; D005840:Gentian Violet / Q000494:pharmacology*; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009824:Ointments; D003668:Pressure Ulcer / Q000382:microbiology*; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
D000891:Anti-Infective Agents, Local; D009824:Ointments; D012996:Solutions; D005840:Gentian Violet