title: [Density of adhesive proteins after oral administration of proteolytic enzymes in multiple myeloma].
abstract: The authors present information on the presence of adhesive proteins on membranes of myeloma and precursor cells isolated from bone marrow and blood from a group of 33 patients examined by fluorescent flow cytometry. They also compare the density of integrins (CD29, CD49e, CD41, CD51 and CD61) and adhesive proteins from the group of "homing" receptors (CD44) and IgG "superfamily" (LFA-1, LFA-3, ICAM-1, N-CAM) and their changes after a single oral dose of a mixture of proteolytic enzymes (Wobe Mugos, Wobenzym, MUCOS Pharma, FRG). The authors observed a significant drop of CD29, CD54 (ICAM-1), CD58 (LFA-3) after Wobe Mugos, CD49, CD51, CD58 after Wobenzyme. The insignificant decline of density of CD44 on cells, as well as of the soluble receptor of CD44 after oral administration of proteolytic enzymes in serum, incl. the mentioned changes of integrins and other adhesive proteins, indicate the importance of enzyme preparations in the supporting treatment of malignant processes.
authors.affiliation: Klinika hematológie a transfuziológie FN a Subkatedra hematológie a transfuziológie IVZ, Bratislava.
authors.forename: A
authors.initials: A
authors.lastname: Sakalová
authors.forename: R
authors.initials: R
authors.lastname: Kunze
authors.forename: D
authors.initials: D
authors.lastname: Holománová
authors.forename: J
authors.initials: J
authors.lastname: Hapalová
authors.forename: B
authors.initials: B
authors.lastname: Chorváth
authors.forename: M
authors.initials: M
authors.lastname: Mistrík
authors.forename: J
authors.initials: J
authors.lastname: Sedlák
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004338:Drug Combinations; D006801:Humans; D006867:Hydrolases / Q000008:administration & dosage*; D016023:Integrins / Q000378:metabolism; D009101:Multiple Myeloma / Q000378:metabolism*; D012431:Rutin / Q000008:administration & dosage*
chemical_list: D000276:Adjuvants, Immunologic; D015815:Cell Adhesion Molecules; D004338:Drug Combinations; D016023:Integrins; D012431:Rutin; C023295:Wobenzym; D006867:Hydrolases