Sweet syndrome associated with G-CSF treatment in a child with glycogen storage disease type Ib.
Acute febrile neutrophilic dermatosis (Sweet syndrome) is rare in children and is regularly associated with underlying malignancies or inflammtory diseases. A 5-year-old girl with glycogen storage disease type Ib, neutropenia, and recurrent infections developed characteristic skin eruption of Sweet syndrome after 2 years of granulocyte colony-stimulating factor (G-CSF) therapy. This association points to a possible role of G-CSF-induced granulopoiesis and granulodyte activation in the pathogenesis of Sweet syndrome.
Garty
B Z
BZ
Levy
I
I
Nitzan
M
M
Barak
Y
Y
D001706:Biopsy; D002675:Child, Preschool; D005260:Female; D005953:Glycogen Storage Disease Type I / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D016463:Sweet Syndrome / Q000139:chemically induced* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor