Replacement of DHEA in aging men and women. Potential remedial effects.
DHEA in appropriate replacement doses appears to have remedial effects with respect to its ability to induce an anabolic growth factor, increase muscle strength and lean body mass, activate immune function, and enhance quality of life in aging men and women, with no significant adverse effects. Further studies are needed to confirm and extend our current results, particularly the gender differences.
Yen
S S
SS
Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093, USA.
Morales
A J
AJ
Khorram
O
O
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000375:Aging; D001823:Body Composition; D018592:Cross-Over Studies; D003687:Dehydroepiandrosterone / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007109:Immunity; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000378:metabolism
D015375:Receptors, Interleukin-2; D003687:Dehydroepiandrosterone; D007334:Insulin-Like Growth Factor I