title: Fractionated Gamma Knife radiosurgery for malignant gliomas: neurobiological effects and FDG-PET studies.
abstract: Experimental single-dose neural irradiation was performed in rats and monkeys. Acute and 'early' late damage was observed following single high-dose treatments. By contrast, following a single low-dose treatment, neither 'early' nor 'delayed' late damage was noted. Based on these experiments, a clinical trial of fractionated Gamma Knife surgery for malignant gliomas was begun, and patients were followed by FDG-PET studies. An acute response of the tumor was obtained without damage to the surrounding brain. Fractionated Gamma Knife surgery is a potential alternative treatment for malignant gliomas.
authors.affiliation: Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: H K
authors.initials: HK
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: J
authors.initials: J
authors.lastname: Ishihara
authors.forename: S
authors.initials: S
authors.lastname: Horikoshi
authors.forename: A
authors.initials: A
authors.lastname: Zama
authors.forename: M
authors.initials: M
authors.lastname: Hirato
authors.forename: T
authors.initials: T
authors.lastname: Shibazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Andou
authors.forename: C
authors.initials: C
authors.lastname: Ohye
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery*; D000882:Haplorhini; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009374:Neoplasms, Experimental / Q000601:surgery; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods; D051381:Rats; D014055:Tomography, Emission-Computed