title: Creatine kinase and creatine kinase-MB release after nontraumatic cardiac arrest.
abstract: The aim of the study was to describe the course of serum creatine kinase (CK) and its MB fraction (CK-MB) in patients surviving cardiac arrest, and to identify factors influencing CK and CK-MB release. The study was set in the community of Vienna, Austria. Data concerning cardiopulmonary resuscitation, collected within a period of 33 months, were evaluated retrospectively and compared with laboratory blood investigations collected prospectively (on admission and after 6, 12, and 24 hours) in 107 adult patients surviving a witnessed cardiac arrest for 24 hours. CK and CK-MB were elevated in >75% of the patients within 24 hours. Release of CK and CK-MB was mainly associated with electrocardiographic evidence of acute myocardial infarction (AMI) cumulative energy administered during defibrillation, and duration of chest trauma by compression. The CK-MB/CK ratio was elevated in 32% of the patients. Of patients with electrocardiographic evidence of AMI, only 49% had an elevated CK-MB/CK ratio. In conclusion, the elevation in serum CK and CK-MB fraction in patients after nontraumatic cardiac arrest is a frequent finding, and is associated with ischemic myocardial injury, as well as physical trauma to the chest. This should be considered when interpreting the course of CK and CK-MB fraction for the diagnosis of AMI.
authors.affiliation: Department of Emergency Medicine, Vienna General Hospital-University of Vienna, Medical School, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Müllner
authors.forename: F
authors.initials: F
authors.lastname: Sterz
authors.forename: M
authors.initials: M
authors.lastname: Binder
authors.forename: M
authors.initials: M
authors.lastname: Brunner
authors.forename: M M
authors.initials: MM
authors.lastname: Hirschl
authors.forename: G
authors.initials: G
authors.lastname: Mustafa
authors.forename: W
authors.initials: W
authors.lastname: Schreiber
authors.forename: I
authors.initials: I
authors.lastname: Kürkciyan
authors.forename: H
authors.initials: H
authors.lastname: Domanovits
authors.forename: A N
authors.initials: AN
authors.lastname: Laggner
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006323:Heart Arrest / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase