[Glaucoma in Marfan syndrome: position-dependent measurement of intraocular pressure as a diagnostic criterium].
A 35-year-old female patient with Marfan's syndrome presented with fast progressive reduction of visual acuity (hand movements) of her right eye and lens-related glaucoma on both eyes. On examination, subluxation of the lens and nuclear cataract were seen on both eyes. Diurnal pressure curve showed great fluctuations in pressure with normal IOP in the morning and elevated pressure in the evening. Pressure measurement revealed great fluctuations depending on positioning. Because of cataractous lens in the right eye blocking the visual axis and uncontrollable, phacogenic glaucoma removal of the lens by cryoextraction was necessary. Visual acuity increased to 0.5 and IOP was normal after three weeks. To improve safety of topical medication of lens-related glaucoma in Marfan's syndrome regular measurement of IOP at different times of the day is especially important. Measurement of IOP at different positions seems to be an effective provocation test in cases of phacogenic glaucoma in Marfan's syndrome. Examination of all members of a family with Marfan's syndrome should include regular measurement of IOP at different times of the day. In suspected cases, measurement of IOP at different positions that may provoce IOP-increase could be useful in the early detection of lens-related glaucoma.
Schlote
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T
Abteilung I (Allgemeine Augenheilkunde mit Poliklinik), Universitäts-Augenklinik Tübingen.
Völker
M
M
Thanos
S
S
Thiel
H J
HJ
D000328:Adult; D002386:Cataract / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000235:genetics / Q000502:physiology*; D007906:Lens Subluxation / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D008382:Marfan Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D016684:Prone Position / Q000502:physiology*; D012029:Refraction, Ocular; D016683:Supine Position / Q000502:physiology*; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology