CD36 and intercellular adhesion molecule 1 mediate adhesion of developing Plasmodium falciparum gametocytes.
Plasmodium falciparum trophozoite-infected erythrocytes adhere to the amelanotic melanoma C32 cell line in vitro. Here we demonstrate for the first time that immature gametocyte-infected erythrocytes also adhere to C32 cells, albeit at lower levels than trophozoites. However, anti-CD36 and anti-intercellular adhesion molecule 1 antibodies inhibit asexual and gametocyte adhesion by comparable percentages, suggesting a common dependency for binding to these cellular receptors.
Rogers
N J
NJ
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, United Kingdom.
Daramola
O
O
Targett
G A
GA
Hall
B S
BS
D000268:Adhesiveness; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D018955:CD36 Antigens / Q000502:physiology*; D005260:Female; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology*; D008297:Male; D010963:Plasmodium falciparum / Q000502:physiology*; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D018955:CD36 Antigens; D018799:Intercellular Adhesion Molecule-1