title: Structure-activity relationships of synthetic saponins.
abstract: The haemolytic and antifungal activities of synthetic diosgenyl, tigogenyl, hecogenyl, methyl oleanolate, methyl ursolate and methyl glycyrrhetinate glycosides were compared with each other. Both activities of the steroid glycosides were generally parallel to each other, while almost all haemolytic triterpenoid glycosides showed no antifungal activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takechi
authors.forename: C
authors.initials: C
authors.lastname: Uno
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D012503:Saponins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012756:Sheep; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D012503:Saponins