title: Preoperative biliary drainage in obstructive jaundice.
abstract: OBJECTIVE
  Although the role of preoperative percutaneous transhepatic biliary drainage in obstructive jaundice has been the subject of controversy in many other countries, in Japan, almost all surgeons agree that biliary decompression should be performed prior to the surgical treatment in obstructive jaundice. This study was performed in order to determine the role of preoperative percutaneous transhepatic biliary drainage in obstructive jaundice.
  
  
  METHODS
  We evaluated 238 patients with preoperative obstructive jaundice, and also studied its pathophysiology in experimental animal models.
  
  
  RESULTS
  Both of these studies demonstrated that this procedure should be performed if the value of total bilirubin is more than 5 mg/dl, the ICG Rmax value of the future remnant liver is less than 0.4 mg/kg/min, and the duration of jaundice is more than 3 weeks. Preoperative biliary drainage improves the liver function, so that major operations can be safely performed without major complications.
  
  
  CONCLUSIONS
  It therefore seems preferable that patients undergo preoperative biliary decompression to reduce serum total bilirubin to below 5 mg/dl, and to improve hepatic and reticuloendothelial functions and hepatic reserve prior to any major surgical operation.
authors.affiliation: First Department of Surgery, Mie University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawarada
authors.forename: T
authors.initials: T
authors.lastname: Higashiguchi
authors.forename: H
authors.initials: H
authors.lastname: Yokoi
authors.forename: P
authors.initials: P
authors.lastname: Vaidya
authors.forename: R
authors.initials: R
authors.lastname: Mizumoto
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D002985:Clinical Protocols; D004285:Dogs; D004322:Drainage; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012189:Retrospective Studies
chemical_list: D001663:Bilirubin