2-Arylmethyl-1,4-benzoquinones. I. Novel inhibitors of platelet aggregation: synthesis and pharmacological evaluation.
A new series of 2-arylmethyl-1,4-benzoquinones (2) was synthesized for evaluation of their pharmacological activities. These compounds showed significant inhibition of platelet aggregation induced by arachidonic acid (AA) and some of them possessed a protective effect against endothelial cell injury caused by hydrogen peroxide.
Suzuki
K
K
Suntory Institute for Biomedical Research, Osaka, Japan.
Tatsuoka
T
T
Murakami
T
T
Ishihara
T
T
Aisaka
K
K
Inoue
T
T
Ogino
R
R
Kuroki
M
M
Miyazaki
T
T
Satoh
F
F
Miyano
S
S
Sumoto
K
K
D000818:Animals; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits
D016227:Benzoquinones; D010975:Platelet Aggregation Inhibitors