[Recent aspects of liver biochemistry: from physiopathology to functional liver exploration].
The advent of liver transplantation and the availability of effective medical therapeutics have recently made possible treatments of chronic liver diseases. These improvements have evidenced new needs for evaluation of the treated patients. In this review, authors present new biochemical liver tests proposed for a better monitoring in the course of the disease, to assess the therapeutic response in clinical trials and to reduce the number of liver biopsies. The different aspects of this paper concern the evaluation of hepatic uptake and biliary elimination, cholestasis, jaundice, cellular injury, fibrosis and liver tumor.
Guéchot
J
J
Service de biochimie A, hôpital Saint-Antoine, France.
Gerhardt
M
M
Imbert-Bismut
F
F
Jezequel-Cuer
M
M
Myara
A
A
Vassault
A
A
Vaubourdolle
M
M
Voitot
H
H
D001219:Aspartate Aminotransferases / Q000378:metabolism; D001663:Bilirubin; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control; D002779:Cholestasis / Q000378:metabolism / Q000503:physiopathology; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007565:Jaundice / Q000378:metabolism / Q000503:physiopathology; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000097:blood; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000517:prevention & control; D008657:Metabolic Clearance Rate
D015415:Biomarkers; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D001663:Bilirubin