Cardiac function of an acute ischemic heart failure model produced by microsphere injection into the left coronary artery. Pressure-volume relationship as determined by a conductance catheter.
The authors produced an acute canine heart failure model by injecting microspheres (phi 15.5 +/- 0.1 mm, 5 x 10(5)) into the left coronary artery, and characterized the model in terms of the pressure-volume relationship obtained by the conductance catheter method. Cardiodynamics of the microsphere injection group (M group: n = 10) and control group (C group: n = 12) were studied with 1) heart rate, 2) aortic pressure, 3) cardiac output (CO), 4) maximal ventricular elastance, 5) effective arterial elastance/maximal ventricular elastance, and 6) external work/pressure-volume area efficiency. With microsphere injection, CO and external work/pressure-volume area efficiency significantly decreased. With administration of dobutamine (5 mg/kg/min), CO and maximal ventricular elastance recovered to normal and aortic pressure became higher than normal. These changes in heart rate, aortic pressure, CO, maximal ventricular elastance, and external work/pressure-volume area efficiency in the M group were comparable in percentage to those in the C groups. Cardiodynamics of this heart failure model generally were stable for 3 hrs after microsphere injection. The authors concluded that this model would be an excellent acute heart failure model for investigating hemodynamic effects of circulatory assist devices.
Kuroda
H
H
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Suga
H
H
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization; D002302:Cardiac Output / Q000502:physiology; D003331:Coronary Vessels / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D006329:Heart Conduction System / Q000502:physiology; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D008863:Microspheres; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000503:physiopathology*; D016277:Ventricular Function, Left