The effect of 50 Hz sinusoidal electric and/or magnetic fields on the rate of repair of DNA single/double strand breaks in oxidatively injured cells.
Exposure of cultured mammalian cells to 50 Hz electric (0.2-20 kV/m), magnetic (0.002-2 G), or combined electric and magnetic fields did not affect the rate of repair of DNA single strand breaks (SSB) induced by hydrogen peroxide. The same lack of effect was observed on the repair of both DNA SSBs and DNA double strand breaks (DSBs) in cells treated with the cocktail hydrogen peroxide/L-Histidine. These results indicate that exposure to electric and/or magnetic fields does not affect the machinery involved in the repair of DNA lesions in oxidatively injured cells thus suggesting that it is unlikely that field exposure might induce changes in the response of the cells to the tumor promoting or carcinogenic effects elicited by reactive oxygen species.
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Centro di Metodologie Biochimiche Applicate, Università degli Studi di Urbino, Italy.
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Fiorani
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Dachà
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D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004247:DNA / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000502:physiology*; D004558:Electric Stimulation; D004574:Electromagnetic Fields; D018384:Oxidative Stress
D004277:DNA, Single-Stranded; D004247:DNA