Influence of ethanol on the activity of glycosidases in rats exposed to cadmium (Cd2+).
Inhibition by ethanol of the activities of lysosomal exoglycosidases in stomach, small intestine, liver and brain of rats exposed to cadmium (Cd2+) was determined. Out of the glycosidases tested the most distinct effect of Cd2+ and ethanol administered to the rats in vivo was observed in the small intestinal mucosa in a decreasing order: N-acetyl-beta-hexosaminidase, beta-galactosidase and alpha-fucosidase.
Arciuch
L P
LP
Department of Pharmaceutical Biochemistry, Institute of Chemistry, Białystok 8, Poland.
Omasta
A
A
Rostkowska
K
K
Gałazyn-Sidorczuk
M
M
Moniuszko-Jakoniuk
J
J
Zwierz
K
K
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002104:Cadmium / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D006001:Glycoconjugates / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008361:Mannosidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000201:enzymology; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D043323:alpha-Mannosidase; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
D006001:Glycoconjugates; D002104:Cadmium; D000431:Ethanol; D006026:Glycoside Hydrolases; D008361:Mannosidases; D001616:beta-Galactosidase; D043323:alpha-Mannosidase; D005644:alpha-L-Fucosidase; D001619:beta-N-Acetylhexosaminidases