Analysis of the Wilms tumor suppressor gene WT1 in endometrial carcinoma.
This study reports on the evaluation of the Wilms tumor suppressor gene WT1 in 14 endometrial carcinomas. Despite the fact that several endometrial carcinomas were shown to express WT1, we were unable to demonstrate mutations in the MT1 zinc finger region, suggesting that WT1 does not play a prominent role in the etiology of this malignancy.
Rackley
R
R
Department of Urology, Cleveland Clinic Foundation, Ohio, USA.
Casey
G
G
Zhao
X L
XL
Miller
D W
DW
Williams
B R
BR
Coppes
M J
MJ
D001483:Base Sequence; D002277:Carcinoma / Q000209:etiology / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000209:etiology / Q000235:genetics*; D005260:Female; D016162:Genes, Wilms Tumor; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics*; D025721:WT1 Proteins; D016335:Zinc Fingers / Q000235:genetics; D001613:beta 2-Microglobulin / Q000235:genetics
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D025721:WT1 Proteins; D001613:beta 2-Microglobulin