Vaninolol: a novel compound for the treatment of glaucoma and ischemic retinopathy.
Vaninolol has been confirmed as a selective beta 1-adrenergic blocking agent. The new compound was studied for its effects on intraocular pressure (IOP), the ocular blood flow and the retinal function in this report. Vaninolol showed marked delay in IOP recovery demonstrating that the agent possessed an ocular hypotensive action. This effect is equipotent or slightly more active than L-timolol. In addition, effects of vaninolol on the ocular blood flow of ocular hypertensive eyes were determined using the colored microspheres technique. It was found that vaninolol improved the ocular blood flow in ciliary body and retina, but not in iris and choroid. Further, vaninolol is able to improve the b-wave recovery in electroretinography significantly, indicating that it is possible to develop a new agent for the treatment of ischemic retinopathy.
Wu
B N
BN
Department of Pharmacology, Kaohsiung Medical College, Taiwan, Republic of China.
Hong
S J
SJ
Sheu
M M
MM
Chen
I J
IJ
Liu
S X
SX
Chiou
G C
GC
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002074:Butanones / Q000494:pharmacology* / Q000627:therapeutic use; D004596:Electroretinography; D005123:Eye / Q000098:blood supply; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D007429:Intraocular Pressure / Q000187:drug effects; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008863:Microspheres; D009798:Ocular Hypertension / Q000188:drug therapy / Q000503:physiopathology; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000502:physiology; D012161:Retinal Artery / Q000187:drug effects / Q000503:physiopathology*; D015356:Retinal Artery Occlusion / Q000188:drug therapy* / Q000503:physiopathology; D013999:Timolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D002074:Butanones; D011412:Propanolamines; C088562:vaninolol; D013999:Timolol