title: Information processing in patients with early and continuously-treated phenylketonuria.
abstract: A total of 33 patients with early and continuously-treated phenylketonuria (PKU) between 7 and 16 years of age and 33 matched controls participated in a study examining perceptual, central, and response-related mechanisms of information processing. The specific mechanisms studied were: perceptual filtering, memory search, response selection, response execution, and motor presetting. In addition, groups were compared on mean intelligence level and task oriented behaviour. The performance of the PKU patients practically matched that of the controls on all three tasks, suggesting that PKU patients who are continuously maintained on a well-controlled phenylalanine-restricted diet are not impaired in the elementary mechanisms of information processing. Furthermore, groups did not differ in mean IQ or task-oriented behaviour.
  
  
  CONCLUSIONS
  These results underline the importance of continued, well-controlled dietary treatment. Further studies are recommended to obtain a more complete evaluation of the potential of PKU patients under these stricter dietary treatment conditions.
authors.affiliation: Department of Developmental and Experimental Clinical Psychology, State University Groningen, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: Stemerdink
authors.forename: J J
authors.initials: JJ
authors.lastname: van der Meere
authors.forename: M W
authors.initials: MW
authors.lastname: van der Molen
authors.forename: A F
authors.initials: AF
authors.lastname: Kalverboer
authors.forename: M M
authors.initials: MM
authors.lastname: Hendrikx
authors.forename: J
authors.initials: J
authors.lastname: Huisman
authors.forename: L W
authors.initials: LW
authors.lastname: van der Schot
authors.forename: F M
authors.initials: FM
authors.lastname: Slijper
authors.forename: F J
authors.initials: FJ
authors.lastname: van Spronsen
authors.forename: P H
authors.initials: PH
authors.lastname: Verkerk
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D016555:Matched-Pair Analysis; D008606:Mental Processes; D010661:Phenylketonurias / Q000523:psychology* / Q000628:therapy; D013647:Task Performance and Analysis