The synthesis of 19-norandrostenedione from dehydroepiandrosterone in equine placenta is inhibited by aromatase inhibitors 4-hydroxyandrostenedione and fadrozole.
19-Norandrostenedione was synthesized in vitro from dehydroepiandrosterone by explants of equine full-term placenta. The synthesis of 19-norandrostenedione was inhibited by two specific aromatase inhibitors, 4-hydroxyandrostenedione and fadrozole.
Moslemi
S
S
Laboratoire de Biochimie, Centre National de la Recherche Scientifique URA 609, Université de Caen, France.
Silberzahn
P
P
Gaillard
J L
JL
D000735:Androstenedione / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D047072:Aromatase Inhibitors; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D017316:Fadrozole / Q000494:pharmacology; D005260:Female; D006736:Horses / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D017316:Fadrozole; C014594:formestane; C002828:19-norandrostenedione