Prevention of hypercholesterolemia and atherosclerosis in rabbits after supplementation of Myristica fragrans seed extract.
Myristica seed extr. administration to hypercholesterolemic rabbits reduced serum cholesterol and LDL Cholesterol by 69.1% and 76.3% respectively and also lowered cholesterol/phospholipid ratio by 31.2% and elevated the decreased HDL-ratio significantly. Myristica seed extr. feeding also prevented the accumulation of cholesterol, phospholipids and triglycerides in liver, heart and aorta and dissolved atheromatous plaques of aorta by 70.9-76.5%. Fecal excretion of cholesterol and phospholipid were significantly increased in seed extract fed rabbits.
Sharma
A
A
Department of Zoology, University of Rajasthan, Jaipur.
Mathur
R
R
Dixit
V P
VP
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000517:prevention & control*; D008076:Cholesterol, HDL / Q000097:blood; D004032:Diet; D005243:Feces / Q000737:chemistry; D006937:Hypercholesterolemia / Q000473:pathology / Q000517:prevention & control*; D007194:India; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000097:blood; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008055:Lipids; D010743:Phospholipids; D010936:Plant Extracts