title: Localized retroperitoneal fibromatosis causing intestinal obstruction in a cynomolgus monkey (Macaca fascicularis).
abstract: Gross examination of a 24-month-old, male cynomolgus monkey (Macaca fascicularis) revealed obstruction of the ileum by a mass that entrapped and compressed the ileocecal junction. The mass was well circumscribed, firm, and white on cut surface. Histologically, the mass consisted of spindle-shaped cells arranged in interweaving bundles or as narrow cords and individual cells widely separated by dense collagen. A diagnosis of localized retroperitoneal fibromatosis was made based on the characteristic gross and microscopic findings and isolation of type D simian retrovirus, serotype-2, from spleen and mesenteric lymph node. Monkeys with localized retroperitoneal fibromatosis generally exhibit signs only of a palpable mass at the ileocecal junction and/or nonspecific diarrhea. This case represents an unusual presentation of localized retroperitoneal fibromatosis in which the lesion produced intestinal obstruction and death.
authors.affiliation: Department of Comparative Medicine, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Fikes
authors.forename: M G
authors.initials: MG
authors.lastname: O'Sullivan
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D017809:Fatal Outcome; D007077:Ileal Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D007080:Ileocecal Valve / Q000473:pathology*; D007082:Ileum / Q000737:chemistry / Q000473:pathology; D007415:Intestinal Obstruction / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000209:etiology* / Q000473:pathology; D012185:Retroperitoneal Fibrosis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D015301:Retroviruses, Simian / Q000302:isolation & purification; D013154:Spleen / Q000473:pathology / Q000821:virology
chemical_list: D003094:Collagen