Studies on the effects of monosodium glutamate (MSG) on oxidative stress in erythrocytes of adult male mice.
Subcutaneous administration of monosodium glutamate (MSG) to normal adult male mice for 6 days at dose levels of 4 and 8 mg/g body weight caused a significant increase in erythrocyte glucose content accompanied by increased lipid peroxidation. The levels of total glutathione and protein-bound glutathione were significantly increased in the erythrocytes, whereas non-protein glutathione was significantly decreased. The administration of 4 and 8 mg/g body weight of MSG significantly increased the activities of glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPX). It was observed that MSG, above 4 mg/g body weight, produced oxidative stress which was counteracted by the body by maintaining the level of glutathione, which was done by increasing the activity of its metabolizing enzymes.
Ahluwalia
P
P
Department of Biochemistry, Panjab University, Chandigarh, India.
Tewari
K
K
Choudhary
P
P
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D007279:Injections, Subcutaneous; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000633:toxicity*
D001786:Blood Glucose; D001798:Blood Proteins; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D001205:Ascorbic Acid; D012970:Sodium Glutamate