Modified release matrix prepared by compaction of spheres containing waxy material.
In this study, chlorpheniramine maleate spheres were prepared by the extruder/marumerizer. A new waxy material, Gelucire 50/02 at three levels (10%, 30% and 50%) was added and Avicel PH-101 was used as spheronizing material. The drug was incorporated into the waxy material by two methods. The first was the direct method, in which the drug (10%), wax and Avicel PH-101 were mixed together. The second was the fusion method, in which the drug was dispersed in the melted wax and the solidified mass was milled and mixed with Avicel PH-101. The data obtained indicated that simple addition of waxy material into chlorpheniramine maleate-Avicel PH-101 spheres interrupted matrix formation and increased drug release. Also in this study, a multiparticulate delivery system was prepared successfully by compaction of spheres into tablets. Tablets compacted from spheres prepared by fusion method gave less drug release than those compacted from spheres of the same composition but prepared with direct method. As the level of wax was increased in tablet formulation, drug release was decreased.
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Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
Ghaly
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D002482:Cellulose; D002744:Chlorpheniramine / Q000008:administration & dosage*; D004337:Drug Carriers; D005223:Fats / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009821:Oils / Q000737:chemistry*; D013607:Tablets
D004337:Drug Carriers; D005223:Fats; D009821:Oils; D013607:Tablets; C071183:Gelucire 50-02; D002744:Chlorpheniramine; D002482:Cellulose