Intracellular distribution of Hg2+ applied to epidermis in mice. Analysis of subcellular fractions.
To analyze the permeation of Hg2+ in the epidermis as contact dermatitis allergen, the carrier substances from the HgCl2-treated epidermis were isolated. The peak amount of Hg2+ in the epidermis of mouse tail skin was observed at 12 h after the painting. Thereafter, it remained almost stationary. In the analysis of subcellular fractions, the nuclei fraction showed the highest Hg2+ incorporation, while the soluble protein fraction showed the lowest.
Daian
T
T
Department of Removable Prosthodontics, Nagasaki University School of Dentistry, Japan.
Namikoshi
T
T
Fujii
H
H
D000818:Animals; D004817:Epidermis / Q000378:metabolism*; D005260:Female; D007425:Intracellular Membranes / Q000378:metabolism*; D008628:Mercury / Q000493:pharmacokinetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D010539:Permeability; D013347:Subcellular Fractions / Q000378:metabolism*; D014018:Tissue Distribution
D008628:Mercury