title: Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma.
abstract: OBJECTIVE
  We isolated genes whose expression differs between normal and malignant prostate.
  
  
  METHODS
  Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene.
  
  
  RESULTS
  Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases.
  
  
  CONCLUSIONS
  Early growth response-1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern medical Center, Dallas, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Thigpen
authors.forename: K M
authors.initials: KM
authors.lastname: Cala
authors.forename: J M
authors.initials: JM
authors.lastname: Guileyardo
authors.forename: K H
authors.initials: KH
authors.lastname: Molberg
authors.forename: J D
authors.initials: JD
authors.lastname: McConnell
authors.forename: D W
authors.initials: DW
authors.lastname: Russell
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D051766:Early Growth Response Protein 1; D015972:Gene Expression Regulation, Neoplastic; D017874:Immediate-Early Proteins; D008297:Male; D008969:Molecular Sequence Data; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D012333:RNA, Messenger; D014157:Transcription Factors