title: Intranasal vaccination of pups in the presence of maternally derived antibodies to canine parvovirus (CPV). Evaluation of minimal immunizing dose.
abstract: The results of the intranasal vaccination of pups in the presence of maternally derived antibodies (MDA) to canine parvovirus (CPV) are reported. The minimal immunising dose of the modified live virus vaccine was evaluated in eighteen pups from three litters. Eight pups were vaccinated intranasally with 10(5.50) TCID50/ml of CPV vaccine. Another 8 pups were vaccinated with 10(4.50) TCID50/ml of CPV vaccine and the other 2 pups were vaccinated with 10(3.50) TCID50/ml of CPV vaccine. The vaccine intranasally administered was able to induce a good antibody response in pups with MDA even when the infectious titer per dose was lower than the one contained in parenterally administered vaccines.
authors.affiliation: Istituto di Malattie Infettive e Parassitarie degli animali, Facoltà di Medicina Veterinaria, Valenzano, BA.
authors.forename: C
authors.initials: C
authors.lastname: Buonavoglia
authors.forename: A
authors.initials: A
authors.lastname: Cavalli
authors.forename: M
authors.initials: M
authors.lastname: Tempesta
authors.forename: V
authors.initials: V
authors.lastname: Voight
authors.forename: D
authors.initials: D
authors.lastname: Buonavoglia
authors.forename: M
authors.initials: M
authors.lastname: Corrente
authors.forename: P
authors.initials: P
authors.lastname: Sagazio
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control; D004285:Dogs; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007112:Immunity, Maternally-Acquired; D008297:Male; D010322:Parvoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D017993:Parvovirus, Canine / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines