title: [Emergency therapy of neonatal hyperammonemia with high dosage glucose].
abstract: In severe neonatal hyperammonemia, therapy must be started immediately to prevent irreversible CNS damage. Endogenous ammonia production can be quickly reduced if an anabolic condition is induced by means of high-dose glucose infusion. We applied this treatment to four newborn infants with hyperammonemia, this being a symptom of an inborn error of metabolism. The dangerous metabolic dysfunction was brought under control without dialysis within 24-48 hours in all four patients.
authors.affiliation: Universitäts-Kinderklinik Ulm.
authors.forename: S
authors.initials: S
authors.lastname: Vossbeck
authors.forename: D
authors.initials: D
authors.lastname: Leupold
authors.forename: P
authors.initials: P
authors.lastname: Bartmann
authors.forename: F
authors.initials: F
authors.lastname: Pohlandt
mesh_terms: D000641:Ammonia / Q000097:blood*; D001925:Brain Damage, Chronic / Q000097:blood / Q000517:prevention & control; D002675:Child, Preschool; D003241:Consanguinity; D004630:Emergencies; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D005950:Glucose Solution, Hypertonic; D000641:Ammonia