title: Absorption and excretion of iodixanol after intragastric administration to rats.
abstract: Absorption and excretion of iodixanol 320 mg I/ml were investigated in rats after intragastric administration of 2.5 g I/kg b.w. Animals were observed for up to 96 hours after treatment, and blood, urine and feces taken at several time-points throughout the experiment. Concentrations of iodixanol in serum and urine were measured by means of reversed-phase high-performance liquid chromatography. Fecal concentrations of iodixanol, based on iodine measurements, were determined by X-ray fluorescence spectrometry. Serial radiographs were obtained and histopathological examination was performed on selected tissues. The results indicate that less than 1% of the intragastric dose of iodixanol is absorbed from the intestine into the blood stream. No adverse clinical signs were observed, and there were no treatment-related histomorphological findings.
authors.affiliation: Research & Development, Nycomed Imaging AS, Oslo, Norway.
authors.forename: J A
authors.initials: JA
authors.lastname: Dunkel
authors.forename: I F
authors.initials: IF
authors.lastname: Helund
authors.forename: P B
authors.initials: PB
authors.lastname: Jacobsen
authors.forename: D
authors.initials: D
authors.lastname: Grant
authors.forename: P
authors.initials: P
authors.lastname: Walday
authors.forename: H
authors.initials: H
authors.lastname: Refsum
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol