Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin.
Bacterial colonization of the epithelial cells precedes infection. Mucins of the epithelial cell secretions modulate bacterial colonization. This study was designed to understand the mechanism of mucin-bacterial interactions and in particular binding between nontypeable Haemophilus influenzae and nasopharyngeal mucin(s). In an overlay assay, binding appears to be mediated by outer membrane proteins P2 and P5 of bacteria and sialic acid-containing oligosaccharides of mucin.
Reddy
M S
MS
Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, New York, USA.
Bernstein
J M
JM
Murphy
T F
TF
Faden
H S
HS
D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006193:Haemophilus influenzae / Q000502:physiology*; D006801:Humans; D009077:Mucins / Q000378:metabolism*; D009305:Nasopharynx / Q000382:microbiology*
D001425:Bacterial Outer Membrane Proteins; D009077:Mucins