The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2.
The interferon-inducible double-stranded RNA-specific adenosine deaminase is an RNA-modifying enzyme implicated in the generation of biased hypermutations viral RNAs and the site-selective editing of mammalian mRNAs of neural origin. The gene for the dsRNA-specific adenosine deaminase has been mapped by fluorescence in situ hybridization (FISH) of genomic clones to a single locus on human chromosome 1 bands q21.1-21.2. Simultaneous multicolor FISH including lambda clones and yeast artificial chromosomes showed a localization of the gene in band 1q21 centromeric of D1S1705.
Weier
H U
HU
Center for Molecular Cytogenetics, University of California, Lawrence Berkeley National Laboratory 94720, USA.
George
C X
CX
Greulich
K M
KM
Samuel
C E
CE
D000243:Adenosine Deaminase / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002878:Chromosomes, Human, Pair 1; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007372:Interferons / Q000494:pharmacology*; D012330:RNA, Double-Stranded / Q000378:metabolism*
D012330:RNA, Double-Stranded; D007372:Interferons; D000243:Adenosine Deaminase