title: Lymph node macrophages after application of glucan in calves: an electron microscopical study.
abstract: The present study was designed to reveal by electron microscopy the dynamics of degradation processes of glucan after phagocytosis in the lymph nodes. A soluble form of glucan at a dosage of 50 mg/kg body weight induced a distinct phagocytic activity. On day 7, after stimulation of the lymph nodes, glucan was gradually degraded through fibrillar, particular components, and finally into a light microscopically invisible content. The ingestive capacity of macrophages was higher compared to phagocytic ability of the sinus-lining and reticular cells. On day 30, after stimulation, the lymph nodes indicated restoration of the architecture of their medullary pulp.
authors.affiliation: Department of Pathological Anatomy, University of Veterinary Medicine, Kosice, Slovakia.
authors.forename: L
authors.initials: L
authors.lastname: Kolodzieyski
authors.forename: M
authors.initials: M
authors.lastname: Levkutona
authors.forename: M
authors.initials: M
authors.lastname: Leykut
authors.forename: M
authors.initials: M
authors.lastname: Kokardova
mesh_terms: D000818:Animals; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005936:Glucans / Q000494:pharmacology*; D008198:Lymph Nodes / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D008854:Microscopy, Electron; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology
chemical_list: D005936:Glucans