In vivo neutralization of tetrodotoxin by a monoclonal antibody.
This study examined the ability of monoclonal antibody against TTX to neutralize tetrodotoxin (TTX) in vivo. The mice were injected i.p. with 1.5 mouse units of TTX, followed 3 min later by administering graded doses of antibody immunoglobulin G (IgG). Animals injected with 100 micrograms IgG through the tail vein showed 100% survival. The 50% protective dose was c. 2 mg/kg. The present results indicate that monoclonal antibody can neutralize TTX in vivo.
Matsumura
K
K
Yamaguchi Prefectural Research Institute of Health, Japan.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013623:Tail / Q000098:blood supply; D013779:Tetrodotoxin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000276:immunology
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D013779:Tetrodotoxin