A 50th order reaction predicted and observed for sickle hemoglobin nucleation.
Sickle hemoglobin polymerization exhibits a striking sensitivity to initial concentration, with characteristic reaction times that exhibit 30th power dependence on concentration. This extraordinary reaction order is encompassed by a novel double nucleation mechanism that predicts 50th power dependence of the homogeneous nucleation rate. Using a technique that allows individual homogeneous nucleation events to be monitored, we have measured a concentration dependence of 47+/-, in excellent agreement with the predictions of the model. Absolute nucleation rates agree with predictions as well.
Cao
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Department of Physics and Atmospheric Science, Drexel University, Philadelphia PA 19194, USA.
Ferrone
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FA
D001704:Biopolymers; D006451:Hemoglobin, Sickle / Q000737:chemistry*; D008956:Models, Chemical
D001704:Biopolymers; D006451:Hemoglobin, Sickle