[The use of measuring serum soluble IL-2 receptor levels in cyclosporine-A treated lupus nephritis].
Twenty-one patients with Lupus Nephritis (LN) were treated with cyclosporine-A (CsA) for three months. Serum soluble interleukin-2 receptors (SIL-2R) were measured before and after treatment and correlated prospectively with serologic findings of LN activity. The patients had significantly higher IL-2R level before treatment (during LN flare) than after treatment (disease remission). A significant positive correlation was present between serum SIL-2R and proteinuria, and ANA as well, whereas the SIL-2R levels in LN patients were inversely correlated with serum levels of C3 and CH50. These observations suggest that serum SIL-2R level is an useful marker of disease activity in LN and may serve as a helpful adjunct in the management of this disorder.
Zheng
X
X
Lin
M
M
Cui
X
X
Yao
Q
Q
Zhou
G
G
Guo
Z
Z
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D003176:Complement C3 / Q000378:metabolism; D015941:Complement Hemolytic Activity Assay; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008181:Lupus Nephritis / Q000097:blood / Q000188:drug therapy*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D000974:Antibodies, Antinuclear; D003176:Complement C3; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2; D016572:Cyclosporine