title: Down syndrome and celiac disease.
abstract: Down syndrome is associated with immune-related disorders such as hypothyroidism, insulin-dependent diabetes mellitus, and celiac disease. In this study we determined antigliadin antibodies (AGA) in 54 patients with Down syndrome; 22 had AGA values above the cutoff limit. Nineteen patients underwent intestinal biopsy, and total or subtotal villous atrophy was found in nine. There was a total of 65 patients with Down syndrome in our area of southern Sweden; two were already known to have celiac disease. The minimum prevalence of celiac disease in Down syndrome in this area in southern Sweden was 11 of 65 or 16.9%.
authors.affiliation: Department of Pediatrics, Ryhov Hospital, Jönköping, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Jansson
authors.forename: C
authors.initials: C
authors.lastname: Johansson
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005903:Gliadin / Q000276:immunology; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007422:Intestines / Q000473:pathology; D008297:Male; D013548:Sweden
chemical_list: D000906:Antibodies; D005983:Glutens; D005903:Gliadin