Levels of azithromycin and alpha-1 acid glycoprotein in serum in patients with community-acquired pneumonia.
After an oral dose of 500 mg of azithromycin in patients with community-acquired pneumonia, their serum concentrations ranged between 0.06 and 0.25 mg/liter during the first 12 hours; the calculated percentages of unbound drug varied between 45 and 86%. This study shows that in these patients, the total levels of azithromycin in serum are lower than those expected and that the percentage of bound drug is clinically irrelevant.
Bohte
R
R
Department of Infectious Diseases, University Hospital, RC Leiden, The Netherlands.
Mattie
H
H
van den Broek
P J
PJ
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D017963:Azithromycin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000097:blood* / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D018410:Pneumonia, Bacterial / Q000097:blood* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D009961:Orosomucoid; D017963:Azithromycin