Outcome of amniotic fluid analysis and neonatal respiratory status in diabetic and nondiabetic pregnancies.
OBJECTIVE
To evaluate the likelihood of mature or immature amniotic fluid analysis and subsequent presence or absence of neonatal pulmonary disease in a large population of diabetic and nondiabetic pregnancies.


METHODS
Six hundred sixty-eight pregnancies that delivered within seven days of phosphatidylglycerol (PG) and lecithin/sphingomyelin ratio (L/S) testing were analyzed. (PG testing was by Amniostat-FLM and L/S testing by a modified Gluck technique.) Neonatal respiratory outcome and amniocentesis results were stratified by maternal diabetes status and gestational age for comparison. We determined the likelihood of finding correctly mature and correctly immature amniotic fluid analysis for each gestational age category.


RESULTS
We found high rates of incorrectly immature results for PG (53%) and L/S (21%) preterm and for PG at term (20%). Diabetic and nondiabetic pregnancies did not differ.


CONCLUSIONS
Population-based information on the a priori chances of amniotic fluid and neonatal pulmonary outcome in diabetic and nondiabetic pregnancies is given for use in determining the utility of amniotic fluid analysis in individual clinical settings.
Piper
J M
JM
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio 78284-7836, USA.
Samueloff
A
A
Langer
O
O
D000653:Amniotic Fluid / Q000737:chemistry*; D005260:Female; D005325:Fetal Organ Maturity; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology*; D010713:Phosphatidylcholines / Q000032:analysis; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism; D013109:Sphingomyelins / Q000032:analysis
D010713:Phosphatidylcholines; D013109:Sphingomyelins