title: A comprehensive genetic map of the mouse genome.
abstract: The availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.
authors.affiliation: Whitehead/MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: Dietrich
authors.forename: J
authors.initials: J
authors.lastname: Miller
authors.forename: R
authors.initials: R
authors.lastname: Steen
authors.forename: M A
authors.initials: MA
authors.lastname: Merchant
authors.forename: D
authors.initials: D
authors.lastname: Damron-Boles
authors.forename: Z
authors.initials: Z
authors.lastname: Husain
authors.forename: R
authors.initials: R
authors.lastname: Dredge
authors.forename: M J
authors.initials: MJ
authors.lastname: Daly
authors.forename: K A
authors.initials: KA
authors.lastname: Ingalls
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Connor
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D016678:Genome; D016045:Human Genome Project; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers