Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia.
Polyomavirus enhancer binding protein 2 (PEBP2), also called core binding factor (CBF), is a heterodimer composed of the alpha and the beta subunits. Structural alterations of each of the two subunits generated by recurrent chromosome translocations/inversion are associated with acute myeloid leukemia or acute lymphoblastic leukemia. Chimeric proteins containing a part of either the alpha or beta subunits have a potential to affect the transcriptional regulation through the PEBP2/CBF site. Structure and function of PEBP2/CBF and possible mechanisms of leukemogenesis caused by the chimeric proteins are summarized.
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Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan.
D000818:Animals; D007446:Chromosome Inversion; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000235:genetics; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D014178:Translocation, Genetic
D004268:DNA-Binding Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors