Structure-activity relationships of synthetic cardiac glycosides.
The antiviral, cytotoxic and anti-ATPase activities of 14 synthetic bufalyl glycosides were compared with each other. Among these glycosides, the activities of the gentiobioside and the melibioside were much weaker than those of the others. On the other hand, these three activities were found to be highly correlated with each other. These were parallel to the case of the digitoxigenyl glycosides in our previous paper.
Takechi
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
Uno
C
C
Tanaka
Y
Y
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002301:Cardiac Glycosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002301:Cardiac Glycosides; D004791:Enzyme Inhibitors; D000251:Adenosine Triphosphatases