title: Endometrial laser interstitial hyperthermy: a potential modality for endometrial ablation.
abstract: This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were treated in vitro with an output power of 30 W for 5 minutes; tissue temperatures, recorded by thermocouples, were plotted to draw time-temperature and time-distance curves. As a preliminary series, ten patients were treated, with the first five subjected to local temperature monitoring; all ten were followed-up for 6-17 months. Immediate and delayed (6 weeks) histologic data were obtained. The intramural temperature at 6 mm from the fibers ranged from 55-60C). In vivo, the cooling effect of the arterial blood flow lowered the serosal temperatures under 41C. The histologic data and the hysterographic pictures suggest that endometrial ablation was effective. This new device does not require distending medium, hysteroscopic control, or high-powered Nd-YAG laser machines. Preliminary long-term results suggest that the device could be used for endometrial ablation.
authors.affiliation: Department of Gynecology, Catholic University of Louvain, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Donnez
authors.forename: R
authors.initials: R
authors.lastname: Polet
authors.forename: P E
authors.initials: PE
authors.lastname: Mathieu
authors.forename: E
authors.initials: E
authors.lastname: Konwitz
authors.forename: M
authors.initials: M
authors.lastname: Nisolle
authors.forename: F
authors.initials: F
authors.lastname: Casanas-Roux
mesh_terms: D017115:Catheter Ablation / Q000295:instrumentation*; D004717:Endometrium / Q000601:surgery*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D053685:Laser Therapy / Q000295:instrumentation*; D009354:Neodymium; D015019:Yttrium
chemical_list: D009354:Neodymium; D015019:Yttrium