title: Effects of ACE inhibition on endurance exercise haemodynamics in trained subjects with mild hypertension.
abstract: The aim of the study was to examine the effect of chronic angiotensin converting enzyme inhibition on haemodynamics and left ventricular performance during long-lasting exercise at the anaerobic threshold. For this purpose exercise haemodynamics and left ventricular performance were assessed in 14 physically trained hypertensives (aged 26 y) before and after 3 months on quinapril 20 mg once daily. During exercise intraarterial blood pressure was monitored using the Oxford method and left ventricular dimensions were measured by M-mode echocardiography. Quinapril significantly decreased mean blood pressure during the initial incremental phase of the exercise protocol and caused a slight, nonsignificant decline during the steady-state phase. The drug-induced fall in blood pressure was accounted for mainly by change in cardiac output. Exercise duration and left ventricular performance were not affected by treatment. In conclusion, quinapril 20 mg once daily smoothed the blood pressure increase which occurs during the initial phase of vigorous endurance exercise. This result was achieved without affecting physical performance or left ventricular contractility.
authors.affiliation: Clinica Medica I. University of Padova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Palatini
authors.forename: S
authors.initials: S
authors.lastname: Bongiovi
authors.forename: L
authors.initials: L
authors.lastname: Mario
authors.forename: P
authors.initials: P
authors.lastname: Mormino
authors.forename: G
authors.initials: G
authors.lastname: Raule
authors.forename: A C
authors.initials: AC
authors.lastname: Pessina
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects; D004452:Echocardiography; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005081:Exercise Therapy; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007546:Isoquinolines / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology; D000077583:Quinapril; D044005:Tetrahydroisoquinolines; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077583:Quinapril