title: Studies of human fasciolosis in Egypt: some serum lipid parameters before and after treatment.
abstract: Ten adult patients with proven fasciolosis were enrolled in the study. Serum samples were obtained before and one month after successful treatment using a single oral dose of triclabendazole. It was observed that, serum triglycerides (TG) and very low density lipoproteins (VLDL-C) increased, while serum total cholesterol, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) exhibited a significant decrease. These changes were due to the degenerative necrotic damage of the hepatocytes. One month after treatment, the serum level of total cholesterol, HDL-C and LDL-C gained normal values, indicating recovery of the liver and restoration of its functions in cholesterol synthesis and esterification, while TG and VLDL-C were still significantly higher than control values. This might indicate that hepatic triglyceride lipase requires a longer period to return to a normal level.
authors.affiliation: Department of Parasitology, Alexandria University, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Osman
authors.forename: M
authors.initials: M
authors.lastname: Helmy
authors.forename: M A
authors.initials: MA
authors.lastname: Megehed
mesh_terms: D000328:Adult; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004534:Egypt; D005211:Fascioliasis / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000473:pathology; D009336:Necrosis; D012016:Reference Values; D000077682:Triclabendazole; D014280:Triglycerides / Q000097:blood
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D014280:Triglycerides; D000077682:Triclabendazole; D002784:Cholesterol