title: Cranial MR in Wilson disease: abnormal white matter in extrapyramidal and pyramidal tracts.
abstract: OBJECTIVE
  To describe abnormal white matter in the brain on MR in Wilson disease and to compare with anatomic location of white matter tracts.
  
  
  METHODS
  Forty-six patients with Wilson disease were examined. Axial T1-weighted inversion-recovery, axial T2-weighted spin-echo, and coronal T2*-weighted gradient-echo MR images were performed. Imaging studies were compared with clinical data.
  
  
  RESULTS
  Seventeen patients showed abnormalities in the region coinciding with the following white matter tracts: corticospinal tract (24%, n = 11), dentatorubrothalamic tract (24%, n = 11), and pontocerebellar tract (17%, n = 8).
  
  
  CONCLUSIONS
  Abnormal extrapyramidal and pyramidal white matter tracts are part of the neuroimaging spectrum of Wilson disease. No significant correlation was found with neurologic groups and individual white matter tracts affected.
authors.affiliation: Department of Radiology, University Hospital Utrecht, The Netherlands.
authors.forename: H N
authors.initials: HN
authors.lastname: van Wassenaer-van Hall
authors.forename: A G
authors.initials: AG
authors.lastname: van den Heuvel
authors.forename: G H
authors.initials: GH
authors.lastname: Jansen
authors.forename: T U
authors.initials: TU
authors.lastname: Hoogenraad
authors.forename: W P
authors.initials: WP
authors.lastname: Mali
mesh_terms: D001480:Basal Ganglia Diseases / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D001928:Brain Diseases, Metabolic / Q000175:diagnosis*; D002531:Cerebellum / Q000473:pathology; D003300:Copper / Q000378:metabolism; D005116:Extrapyramidal Tracts / Q000473:pathology*; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009186:Myelin Sheath / Q000473:pathology*; D009460:Neurologic Examination; D010302:Parkinson Disease, Secondary / Q000175:diagnosis; D011149:Pons / Q000473:pathology; D011712:Pyramidal Tracts / Q000473:pathology*
chemical_list: D003300:Copper