Multiple subpial transections for partial seizures in sensorimotor cortex.
We report six patients with complex partial seizures arising from the primary sensorimotor cortex who underwent invasive long-term ictal electroencephalogram/video monitoring and brain mapping and then multiple subpial transections. Although four patients demonstrated no abnormalities on magnetic resonance imaging, each patient showed moderate to marked gliosis in cortex biopsied from the site of ictal onset. Extensive preoperative and postoperative neuropsychological tests demonstrated no functional deficits resulting from surgery. Only one patient failed to derive significant postoperative seizure improvement, and he subsequently underwent additional subpial sectioning without further significant improvement. We propose a modification for this surgical technique and hypothesize that these patients may represent a syndrome of central cortical epilepsy.
Wyler
A R
AR
Epilepsy Center, Swedish Medical Center, Seattle, Washington, USA.
Wilkus
R J
RJ
Rostad
S W
SW
Vossler
D G
DG
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001931:Brain Mapping / Q000295:instrumentation; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000295:instrumentation; D017029:Epilepsy, Complex Partial / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005911:Gliosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010841:Pia Mater / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012086:Reoperation; D012815:Signal Processing, Computer-Assisted; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014741:Video Recording / Q000295:instrumentation