title: Primary cutaneous T-cell-rich B-cell lymphoma. A case report with a 13-year follow-up.
abstract: Cutaneous B-cell lymphomas constitute approximately 20% of primary cutaneous lymphomas. Most histologic subtypes of nodal B-cell lymphomas also occur primarily in the skin. The recently described T-cell-rich B-cell lymphomas (TCRBCLs) manifest mainly in the lymph nodes. This article presents a case of TCRBCL arising primarily in the skin, the origin of which could be traced back 13 years. The patient is a 59-year-old man. Plaque-like and nodular skin infiltrates had first appeared in the left preauricular region. Repeated examinations never found any extracutaneous involvement. A skin biopsy and a retrospectively studied 10-year-old skin specimen showed identical histologic features. Immunohistochemistry identified the TCRBCL previously considered as cutaneous Hodgkin's disease or a diffuse centroblastic centrocytic non-Hodgkin's lymphoma. A clonal B-cell population was detected by polymerase chain reaction, showing a rearrangement of IgH gene. The case of this patient shows that primary cutaneous TCRBCLs, similarly to other B-cell lymphomas in the skin, may have a good prognosis, in contrast to their nodal counterparts.
authors.affiliation: Department of Dermatology, University Hospital Zurich, Switzerland.
authors.forename: S N
authors.initials: SN
authors.lastname: Dommann
authors.forename: C C
authors.initials: CC
authors.lastname: Dommann-Scherrer
authors.forename: D
authors.initials: D
authors.lastname: Zimmerman
authors.forename: M T
authors.initials: MT
authors.lastname: Dours-Zimmermann
authors.forename: S
authors.initials: S
authors.lastname: Hassam
authors.forename: G
authors.initials: G
authors.lastname: Burg
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D004428:Ear Neoplasms / Q000473:pathology; D004431:Ear, External / Q000473:pathology; D005500:Follow-Up Studies; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics; D005803:Genes, Immunoglobulin / Q000235:genetics; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*