title: The effect of progressive resistance training in rheumatoid arthritis. Increased strength without changes in energy balance or body composition.
abstract: OBJECTIVE
  To demonstrate the feasibility of high-intensity progressive resistance training in rheumatoid arthritis (RA) patients compared with healthy control subjects.
  
  
  METHODS
  Eight subjects with RA, 8 healthy young subjects, and 8 healthy elderly subjects underwent 12 weeks of high-intensity progressive resistance training, while 6 elderly subjects performed warm-up exercises only. Fitness, body composition, energy expenditure, function, disease activity, pain, and fatigue were measured at baseline and followup.
  
  
  RESULTS
  All 3 training groups demonstrated similar improvements in strength compared with the change among control subjects (RA group 57% [P < 0.0005], young exercise group 44% [P < 0.01], elderly exercise group 36% [P < 0.05]). Subjects with RA had no change in the number of painful or swollen joints but had significant reductions in self-reported pain score (21% [P < 0.05]) and fatigue score (38% [P = 0.06]), improved 50-foot walking times (mean +/- SD 10.4 +/- 2.2 seconds versus 8.3 +/- 1.5 seconds [P < 0.005]), and improved balance and gait scores (48.9 +/- 3.8 versus 50.4+/- 2.0 [P = 0.07]).
  
  
  CONCLUSIONS
  High-intensity strength training is feasible and safe in selected patients with well-controlled RA and leads to significant improvements in strength, pain, and fatigue without exacerbating disease activity or joint pain.
authors.affiliation: USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, 02111, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Rall
authors.forename: S N
authors.initials: SN
authors.lastname: Meydani
authors.forename: J J
authors.initials: JJ
authors.lastname: Kehayias
authors.forename: B
authors.initials: B
authors.lastname: Dawson-Hughes
authors.forename: R
authors.initials: R
authors.lastname: Roubenoff
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000628:therapy*; D001835:Body Weight; D004435:Eating; D004734:Energy Metabolism; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D007551:Isotonic Contraction; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness; D016896:Treatment Outcome