title: Serological comparison of type Asia 1 foot and mouth disease virus isolates from Thailand.
abstract: Antigenic variation of type Asia 1 foot and mouth disease (FMD) virus in Thailand was examined using a total of 50 field viruses isolated between 1986 and 1992. A two-dimensional serum neutralisation test was used to calculate r values for comparison of these isolates with a reference vaccine strain, Asia 1 Bangkok 1960 (BKK/60). Viruses were also compared to two field isolates, Asia 1 36-2/88 and Asia 1 45/88, and some were compared to another vaccine strain, Asia 1 Nakhon Pathom 1984 (NPT/84). In 80% of cases, field isolates were deemed to be significantly different from the vaccine virus Asia 1 BKK/60, and the distribution of r values indicated that there would be some advantage in selecting a new vaccine strain more closely related to contemporary field strains.
authors.affiliation: Commonwealth Scientific and Industrial Research Organisation, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors.forename: W J
authors.initials: WJ
authors.lastname: Doughty
authors.forename: L J
authors.initials: LJ
authors.lastname: Gleeson
authors.forename: K
authors.initials: K
authors.lastname: Prasatsuwan
authors.forename: A
authors.initials: A
authors.lastname: Kongthon
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D005537:Aphthovirus / Q000145:classification / Q000276:immunology*; D002020:Buffaloes; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000821:virology; D002460:Cell Line; D006224:Cricetinae; D004196:Disease Outbreaks / Q000662:veterinary; D005536:Foot-and-Mouth Disease / Q000453:epidemiology / Q000821:virology*; D009500:Neutralization Tests / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology; D013785:Thailand / Q000453:epidemiology