Preparation and pharmacological evaluation of 1-(1,4-benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes as potent cerebral protective agents.
Two new series of 1-(1,4-benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes (3,4) were synthesized for evaluation of their pharmacological activities. These compounds showed significant anti-lipid peroxidation (ALP) activities with rat brain homogenate and some of them possessed a protective effect against hypobaric hypoxia in mice.
Suzuki
K
K
Suntory Institute for Biomedical Research, Osaka, Japan.
Tatsuoka
T
T
Ishihara
T
T
Ohno
T
T
Aisaka
K
K
Ogino
R
R
Kuroki
M
M
Satoh
F
F
Miyano
S
S
Sumoto
K
K
D000818:Animals; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy; D002560:Cerebrovascular Circulation / Q000187:drug effects; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D016227:Benzoquinones; D018696:Neuroprotective Agents; D013764:Tetrahydronaphthalenes