title: Complete remission seven years after treatment for metastatic malignant melanoma.
abstract: BACKGROUND
  In this study, the authors identified seven-year survivors after completion of the French multicenter Phase II trial of fotemustine for the treatment of metastatic malignant melanoma.
  
  
  METHODS
  One hundred sixty-nine patients with metastatic malignant melanoma were included in this Phase II study. One hundred fifty-three patient records were evaluable with an overall response rate of 24.2%.
  
  
  RESULTS
  Five of these patients are alive and in complete remission. One patient had a complete response after fotemustine administration and then relapsed. One patient had a partial response. Three patients had stable disease. These five patients underwent surgery for relapse or residual disease and subsequently achieved durable complete remission.
  
  
  CONCLUSIONS
  Long term survival may be the outcome after surgical resection of residual metastatic melanoma after chemotherapy.
authors.affiliation: Medical Oncology Unit, Salpetriere Hospital, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Petit
authors.forename: C
authors.initials: C
authors.lastname: Borel
authors.forename: O
authors.initials: O
authors.lastname: Rixe
authors.forename: M F
authors.initials: MF
authors.lastname: Avril
authors.forename: A
authors.initials: A
authors.lastname: Monnier
authors.forename: B
authors.initials: B
authors.lastname: Giroux
authors.forename: M
authors.initials: M
authors.lastname: Weil
authors.forename: D
authors.initials: D
authors.lastname: Khayat
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000601:surgery; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D012074:Remission Induction; D013160:Splenic Neoplasms / Q000556:secondary / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; C054368:fotemustine