Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. II. Isolation, physico-chemical properties and structure elucidation.
Sparoxomycins A1 and A2, isolated from the fermentation broth and mycelium of Streptomyces sparsogenes SN2325, are new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. Sparoxomycins A1 and A2 were isolated by active carbon chromatography, centrifugal partition chromatography (CPC), ODS column chromatography and preparative HPLC. The structure of sparoxomycins were determined by spectroscopic evidences. Stereochemical assignments of these inducers were executed from the analyses of CD spectra.
Ubukata
M
M
The Institute of Physical and Chemical Research (RIKEN), Saitama 351-01, Japan.
Morita
T I
TI
Uramoto
M
M
Osada
H
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification*; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D008968:Molecular Conformation; D011744:Pyrimidinones / Q000737:chemistry / Q000302:isolation & purification; D013696:Temperature
D000903:Antibiotics, Antineoplastic; D011744:Pyrimidinones; C098364:sparoxomycin A1