[Role of gamma-delta T-cells and heat shock proteins in immunological response and in pathogenesis of neurological diseases].
T cells with gamma delta receptor form small percentage of lymphocytes in healthy individuals, whereas their number increases in persons with immunological disorders. Heat shock proteins (HSPs), which play a central role in protein transformation, could be antigens for gamma delta T cells. HSPs participate in mutual interactions of gamma delta cells and tissue cells, taking part in defense mechanism against infection and auto destruction. There is an interest' in the HSPs' role in modulation of both normal and pathological activity within the nervous system. HSPs can protect cells against undesired stimulation, probably by long-term protein expression. Results of the studies suggest participation of gamma delta T cells and HSPs in pathogenesis of certain diseases, including neurological ones (multiple sclerosis, Alzheimer's disease, Parkinson's disease and cerebrovascular diseases), although detailed explanation of this problem requires further studies.
Fiszer
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II Kliniki Neurologicznej, Instytutu Psychiatrii i Neurologii w Warszawie.
D001927:Brain Diseases / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*
D006360:Heat-Shock Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta