title: Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents.
abstract: We have created databases and software applications for the analysis of DNA mutations in the human p53 gene, the human hprt gene and the rodent transgenic lacZ locus. The databases themselves are stand-alone dBase files and the software for analysis of the databases runs on IBM- compatible computers. The software created for these databases permits filtering, ordering, report generation and display of information in the database. In addition, a significant number of routines have been developed for the analysis of single base substitutions. One method of obtaining the databases and software is via the World Wide Web (WWW). Open home page http://sunsite.unc.edu/dnam/mainpage.ht ml with a WWW browser. Alternatively, the databases and programs are available via public ftp from anonymous@sunsite.unc.edu. There is no password required to enter the system. The databases and software are found in subdirectory pub/academic/biology/dna-mutations. Two other programs are available at the WWW site, a program for comparison of mutational spectra and a program for entry of mutational data into a relational database.
authors.affiliation: Glaxo Wellcome Inc., Medicines Safety Evaluation, Research Triangle Park, NC 27709, USA.
authors.forename: N F
authors.initials: NF
authors.lastname: Cariello
authors.forename: G R
authors.initials: GR
authors.lastname: Douglas
authors.forename: T
authors.initials: T
authors.lastname: Soussi
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003195:Computer Communication Networks; D016208:Databases, Factual; D016158:Genes, p53; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D007763:Lac Operon; D009154:Mutation; D012377:Rodentia / Q000235:genetics; D012984:Software
chemical_list: D007041:Hypoxanthine Phosphoribosyltransferase