title: Late solitary cerebral metastasis from renal cell carcinoma: a case report and review of the literature.
abstract: Metastatic disease to the brain occurs in 5%-10% of cases of renal cell carcinoma (RCC). Solitary involvement of the brain is less common with a reported incidence of 0.6%-2.5% in large autopsy series. In a review of the literature, only five cases of solitary brain metastasis from RCC with a latency period greater than 10 years have been documented. In this article, we report the case of an 86-year-old white female who developed a brain metastasis 15 years after nephrectomy. As a result of our experience with this patient and a review of the literature, we conclude that in patients with a history of RCC, metastatic lesions from the primary tumor must remain in the differential when evaluating any subsequent brain lesion, as metastases may appear well over a decade after nephrectomy.
authors.affiliation: Cancer Care Center of Southern West Virginia, Charleston Area Medical Center, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Jubelirer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000453:epidemiology / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000556:secondary*; D005260:Female; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000473:pathology*; D009392:Nephrectomy; D013997:Time Factors