The effect of Ambroxol on bleomycin-induced changes in phospholipid composition of rat lung surfactant.
The influence of Ambroxol on bleomycin-induced changes in lung surfactant phospholipid composition in rats was examined. Bleomycin alone (intratracheally 10 mg/kg, single dose) produces a significant fall in phosphatidylcholine (especially in disaturated species) and phosphatidylglicerol content in both lavage and postlavaged lung tissues surfactants. Ambroxol (8 days, 2 mg/kg s.c. per day) normalizes these changes. Thus, Ambroxol has an salutary effect on bleomycin-induced changes in lung surfactant phospholipids.
Stettner
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S
I Clinic of General Surgery, Medical Academy, Lublin, Poland.
Ledwozyw
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D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001992:Bronchoalveolar Lavage Fluid; D005100:Expectorants / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D005100:Expectorants; D010743:Phospholipids; D011506:Proteins; D011663:Pulmonary Surfactants; D001761:Bleomycin; D000551:Ambroxol