title: The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats.
abstract: The concentrations of diminazene aceturate in the brain of Trypanosoma brucei brucei infected and uninfected rats treated with diminazene aceturate (3.1 mg/kg, im) and either LiCl (2.5, 5.0 and 10 micrograms/kg) or sucrose (0.25, 0.5 and 1.0 g/kg) were determined. When diminazene aceturate was administered at a standard dose of 3.1 mg/kg (im), the addition of LiCl (10 micrograms/kg, im) increased significantly (P < 0.05) the concentration of the drug in the brains of both trypanosome infected and normal infected rats. The addition of sucrose (1.0 g/kg, im) instead of LiCl failed to give any significant increase in diminazene aceturate levels in the brain. The diminazene aceturate levels were significantly (P < 0.05) higher in the organs (brain, kidney, liver and spleen) of trypanosome infected compared to uninfected rats. The concentration of diminazene aceturate in the organs increased significantly (P < 0.05) with increasing concentrations of LiCl.
authors.affiliation: Department of Vet. Physiology and Pharmacology, Usman Danfodiyo University, Sokoto, Nigeria.
authors.forename: I E
authors.initials: IE
authors.lastname: Odika
authors.forename: I U
authors.initials: IU
authors.lastname: Asuzu
authors.forename: S M
authors.initials: SM
authors.lastname: Anika
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D004133:Diminazene / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D018021:Lithium Chloride / Q000494:pharmacology*; D008297:Male; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000494:pharmacology*; D014018:Tissue Distribution; D014344:Trypanocidal Agents / Q000493:pharmacokinetics*; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D014344:Trypanocidal Agents; D013395:Sucrose; D018021:Lithium Chloride; C003915:diminazene aceturate; D004133:Diminazene