Analogue of aspartate and glutamate active at synapses are attractants for Escherichia coli.
1. This research was carried out to compare Escherichia coli bacteria with animals in their response to L-aspartate and L-glutamate and their analogues. 2. Various analogues of aspartate and glutamate known to be neurotransmitters at synapses were shown to be attractants for E. coli. 3. The amino acid sequences of the animal receptors and the bacterial receptor, however, have no detectable relationship. Based on the amino acid sequence, evolutionarily the two systems appear not to be related.
Lake
E M
EM
Department of Biochemistry, University of Wisconsin-Madison 53706, USA.
Jiang
H
H
Blattner
F R
FR
Adler
J
J
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology*; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013569:Synapses
D002630:Chemotactic Factors; D001224:Aspartic Acid; D018698:Glutamic Acid