Methods for the transcervical collection of fetal cells during the first trimester of pregnancy.
Before termination of pregnancy, four techniques for retrieving fetal cells transcervically were investigated: uterine lavage, endocervical lavage, cytobrush and mucus aspiration. The yield of fetal cells in these samples was studied and found to be somewhat better after uterine lavage. A preliminary assessment of the safety of mucus aspiration was carried out before transcervical chorionic villus sampling (CVS) in continuing pregnancies. No difference in outcome to a control group having only CVS was found.
Rodeck
C
C
Department of Obstetrics and Gynaecology, University College London, U.K.
Tutschek
B
B
Sherlock
J
J
Kingdom
J
J
D001706:Biopsy; D002584:Cervix Uteri; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D005333:Fetus / Q000166:cytology*; D005500:Follow-Up Studies; D006801:Humans; D001239:Inhalation; D009093:Mucus; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D007507:Therapeutic Irrigation