title: Effect of a baking soda-peroxide dentifrice on post-surgical wound healing.
abstract: OBJECTIVE
  To investigate the effect of a baking soda-hydrogen peroxide (0.75%) dentifrice on wound healing, plaque formation, gingival inflammation, patient comfort, probing depth, and clinical attachment level following gingival flap surgery.
  
  
  METHODS
  A randomized, double-blind crossover study involving 25 patients requiring bilateral maxillary gingival flap surgery was completed. The effects of twice daily brushing with a baking soda-hydrogen peroxide dentifrice (Mentadent) or a placebo dentifrice (Crest) were observed over a 28-day post-surgical period. Gingival Index (GI), plaque index (PI), probing depth (PD), clinical attachment level (CAL) and gingival bleeding index (BI) were recorded pre-surgically and at day 28 for each surgical sextant. At days 7 and 14, soft tissue appearance/wound healing (STA) was assessed based on color and edema, PIs were determined and patient comfort was ascertained by report.
  
  
  RESULTS
  Post-surgical wound healing was statistically significantly improved at day 7 with the trend continuing to day 14 when Mentadent dentifrice was used as compared to Crest dentifrice. However, there was no statistical difference in the PI values between the test and control dentifrice throughout the study. Use of Mentadent may be an effective aid in the early phase of healing following gingival flap surgery.
authors.affiliation: Department of Periodontics, School of Dentistry, Marquette University, Milwaukee, WI 53233, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Dentino
authors.forename: S G
authors.initials: SG
authors.lastname: Ciancio
authors.forename: M
authors.initials: M
authors.lastname: Bessinger
authors.forename: M A
authors.initials: MA
authors.lastname: Mather
authors.forename: L
authors.initials: L
authors.lastname: Cancro
authors.forename: S
authors.initials: S
authors.lastname: Fischman
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D003802:Dentifrices / Q000494:pharmacology*; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control; D005260:Female; D005891:Gingivitis / Q000517:prevention & control; D005893:Gingivoplasty / Q000379:methods*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain; D010512:Periodontal Index; D011184:Postoperative Period; D017693:Sodium Bicarbonate / Q000494:pharmacology*; D013524:Surgical Flaps; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; C098761:Mentadent Dentifrice; D017693:Sodium Bicarbonate; D006861:Hydrogen Peroxide