title: Increase in oxygen tension after intraperitoneal N-methyl-DL-aspartate in rat cerebral cortex.
abstract: An oxygen electrode equipped with a thermocouple enabled us to determine the absolute oxygen tension (PO2) in brain regions by taking account of local changes in temperature. Under urethane anesthesia, the PO2 of rat cerebral cortex was significantly increased up to 90 min after N-methyl-DL-aspartate administration (200 mg/kg, i.p.). This suggests that stimulation of NMDA receptors enhances oxygen supply to the cerebrum in vivo.
authors.affiliation: Department of Forensic Medicine, Tokyo Medical College, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Mukai
authors.forename: F
authors.initials: F
authors.lastname: Kuriiwa
authors.forename: N
authors.initials: N
authors.lastname: Iwata
authors.forename: S
authors.initials: S
authors.lastname: Kano
authors.forename: T
authors.initials: T
authors.lastname: Endo
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D008839:Microelectrodes; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013696:Temperature
chemical_list: D018690:Excitatory Amino Acid Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D010100:Oxygen