The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats.
Serum sodium (Na), potassium (K), chloride (Cl), phosphate (Po), and calcium (Ca) were assayed in adult male Wistar rats fed a low protein diet (LP) and a normal protein diet (control, NP) and administered gossypol (GP) and chloroquine (CQ) alone and in combination (GPCQ), for 4 and 8 weeks. Gossypol was administered at 20 mg/kg body wt/rat/day in Goya oil and chloroquine at 5 mg/kg body wt/rat for 3 days/week in distilled water. The data, analyzed by two-way ANOVA, showed that the interaction had significant effects on the serum levels of Na, K and Po (P < 0.001) but not on chloride and calcium (P > 0.05). Serum levels of sodium, potassium and phosphate in LP rats were significantly lower than in NP rats. In LP and NP rats, the levels of Na, K, and Po at 8 weeks were significantly higher than at 4 weeks; and GPCQ treatment produced significantly lower sodium levels in LP and NP rats, lower phosphate in LP rats and higher phosphate in NP-fed rats than GP or CQ administered alone. Potassium level in GPCQ was between levels in Gp- and CQ-treated rats. The administration of gossypol and chloroquine together may not adversely affect serum electrolytes in protein-malnutrition state any more than gossypol or chloroquine administered alone.
Nwoha
P U
PU
Department of Anatomy and Cell Biology, Obefemi Awolowo University, Ile-Ife, Nigeria.
Aire
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TA
D000704:Analysis of Variance; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D002738:Chloroquine / Q000494:pharmacology*; D004347:Drug Interactions; D004573:Electrolytes / Q000097:blood*; D006072:Gossypol / Q000494:pharmacology*; D008297:Male; D010710:Phosphates / Q000097:blood; D010940:Plant Proteins / Q000494:pharmacology; D011502:Protein-Energy Malnutrition / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar / Q000097:blood*; D012964:Sodium / Q000097:blood
D000962:Antimalarials; D002712:Chlorides; D004573:Electrolytes; D010710:Phosphates; D010940:Plant Proteins; D002738:Chloroquine; D012964:Sodium; D006072:Gossypol; D002118:Calcium