In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp.
The in-vitro activity of sertaconazole (7-chloro-3-[1-(2,4-dichlorophenyl- 1-yl)ethoxy-methyl] benzo[b] thiophene) was compared with that of econazole and bifonazole against 150 strains of yeasts which includes six Candida species. Minimum inhibitory concentrations (MICs) were determined by a microdilution technique in Sabouraud's liquid medium, (pH 5.6). Sertaconazole (arithmetic mean MIC 0.77 mg/L) was more active than econazole (MIC 1.75 mg/L) and bifonazole (MIC 9.05 mg/L). MIC values for sertaconazole were generally and specifically lower for each tested species, Candida parapsilosis being the most susceptible (MIC 0.31 mg/L), in contrast to Candida tropicalis, which had the highest MIC (1.67 mg/L).
Carrillo-Muñoz
A J
AJ
Laboratori de Micologia Institut Municipal d'Investigacio Medica Universitat Autonoma de Barcelona, Spain.
Torres-Rodriguez
J M
JM
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D004464:Econazole / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013876:Thiophenes / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; D004464:Econazole; C061131:sertaconazole; C036596:bifonazole