Hospital-acquired acute renal failure in dogs: 29 cases (1983-1992).
OBJECTIVE
To assess factors associated with development of hospital-acquired acute renal failure (HARF) and to determine outcome of and prognostic indicators for dogs with HARF.


METHODS
Retrospective case series.


METHODS
29 dogs.


RESULTS
The most common inciting causes for developments of HARF were exposure to a nephrotoxicant and advanced age. Mortality was 62%, and factors that contributed to mortality were age and initial urine output. Dogs > or = 7 years old and dogs that were initially oliguric had an odds ratio of mortality of 8.8 and 20, respectively. The effect of preexisting heart disease on mortality approached significance (P = 0.053). The magnitude of azotemia at the time of diagnosis was not related to the chance for survival. Dogs that died had a significantly higher initial anion gap and serum phosphorus concentration than did dogs that survived. We did not detect a relationship between cause of HARF and outcome (survived vs died or euthanatized).


CONCLUSIONS
In most cases, HARF is associated with a poor outcome. Older dogs may be at increased risk for development of HARF, and once HARF has developed, have a greater chance of dying. Prognosis can not be determined on the magnitude of azotemia at the time of diagnosis or on the inciting cause of HARF.
Behrend
E N
EN
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
Grauer
G F
GF
Mani
I
I
Groman
R P
RP
Salman
M D
MD
Greco
D S
DS
D000136:Acid-Base Equilibrium; D058186:Acute Kidney Injury / Q000209:etiology / Q000401:mortality / Q000662:veterinary*; D000367:Age Factors; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000209:etiology* / Q000401:mortality; D004285:Dogs; D005260:Female; D007668:Kidney / Q000187:drug effects; D008297:Male; D010758:Phosphorus / Q000097:blood; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
D010758:Phosphorus; D003404:Creatinine