title: Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor.
abstract: Two patients with sclerosing cholangitis presented with a distal stricture of the common bile duct in association with pancreatic pseudotumors. Jaundice resolved following surgery to correct biliary obstruction, but diffuse cholangiographic abnormalities and clinical evidence of sclerosing cholangitis became evident 2 and 4 months later. Rapid progression of symptomatic disease necessitated liver transplantation in one patient, but the other had a complete response to methotrexate therapy. The rapid disease progression in these two patients may have been triggered by surgery that resulted in a generalized fibroproliferative response of the biliary tree, already affected with localized sclerosing cholangitis contiguous to a pancreatic pseudotumor. We suggest that localized sclerosing cholangitis associated with pancreatic pseudotumors may be a unique variant that can progress rapidly but respond dramatically to antiinflammatory therapy.
authors.affiliation: Department of Medicine, University of Chicago Hospitals, Illinois, USA.
authors.forename: G
authors.initials: G
authors.lastname: Stathopoulos
authors.forename: A D
authors.initials: AD
authors.lastname: Nourmand
authors.forename: M
authors.initials: M
authors.lastname: Blackstone
authors.forename: D
authors.initials: D
authors.lastname: Andersen
authors.forename: A L
authors.initials: AL
authors.lastname: Baker
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002760:Cholangiopancreatography, Endoscopic Retrograde; D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D003137:Common Bile Duct Diseases / Q000150:complications / Q000000981:diagnostic imaging; D003251:Constriction, Pathologic; D018450:Disease Progression; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008727:Methotrexate