The re-innervation of the tongue and salivary glands after lingual nerve repair by stretch, sural nerve graft or frozen muscle graft.
The lingual nerve is sometimes injured during the surgical removal of impacted third molar teeth and may require repair. Removal of the damaged section of nerve prior to repair leaves a gap between the nerve ends, and we have investigated methods of closing the gap. THe characteristics of regenerated fibers in the chorda tympani have been recorded in cats 24 weeks after the removal of a segment of lingual nerve and repair of the defect by three methods. The nerve gap was closed either by stretching the nerve ends together and repairing under tension, or by the insertion of a sural nerve graft or freeze-thawed muscle graft. The properties of gustatory, thermosensitive, and mechanosensitive units and the return of the vasomotor and secretomotor responses were investigated by electrophysiological techniques and the data from each of the repair groups compared with those obtained from a series of normal control animals. After each method of repair, the integrated whole-nerve activity recorded from the chorda tympani during gustatory or thermal stimulation of the tongue was reduced when compared with controls, but there was little significant difference between the repair groups. Recordings made from single units in the chorda tympani revealed that conduction velocities were faster after stretch repair than after sural nerve graft or frozen muscle graft. In addition, 48% of the units had developed into principally gustatory units after stretch repair, indicating a better level of recovery than in the graft groups, which contained 33% and 32%, respectively. The secretomotor responses were also significantly greater after stretch repair than in either of the graft groups or the controls, but there was no difference in the vasomotor responses. These results reveal that repair of a short gap in the lingual nerve by stretching the ends together is followed by better overall recovery than after grafting, but where a graft is used, a similar level of recovery results from use of a frozen muscle graft or a sural nerve graft.
Smith
K G
KG
Department of Oral and Maxillofacial Surgery, University of Sheffield, School of Clinical Denstistry, England.
Robinson
P P
PP
D000714:Anastomosis, Surgical; D000818:Animals; D002415:Cats; D016009:Chi-Square Distribution; D002814:Chorda Tympani Nerve / Q000293:injuries* / Q000502:physiology / Q000601:surgery*; D004558:Electric Stimulation; D008036:Lingual Nerve / Q000601:surgery*; D061222:Lingual Nerve Injuries; D008465:Mechanoreceptors / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000637:transplantation; D009412:Nerve Fibers / Q000502:physiology; D009416:Nerve Regeneration; D009431:Neural Conduction; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000294:innervation; D018709:Statistics, Nonparametric; D013497:Sural Nerve / Q000637:transplantation; D013514:Surgical Procedures, Operative / Q000379:methods; D013650:Taste Buds / Q000502:physiology; D013823:Thermoreceptors / Q000502:physiology; D014059:Tongue / Q000294:innervation