Relationships of serum insulin-like growth factor I concentrations to growth, composition, and reproductive traits of swine.
Insulin-like growth factor I (IGF-I) is a peptide hormone that has been shown to be involved in metabolic regulation of growth and reproduction in livestock species. The objectives of this study were to quantify concentrations of IGF-I in growing pigs and determine whether IGF-I concentration can be used as a predictor of growth, composition, and reproductive traits. Forty male and 60 female pigs, divided equally between two locations, were weighed and bled at 3-wk intervals from 6 to 21 wk of age. At each sampling, two blood samples were collected via jugular venipuncture at an interval of at least 1 h. Serum was separated and IGF-I concentration determined via RIA. Pigs were weighed at each sampling date. Backfat and longissimus muscle area were measured with the use of B-mode ultrasound and adjusted to 100 kg. Age at puberty and first-parity litter size were measured on gilts. Effects of age, sex, location, and pig within sex x location on log-transformed IGF-I concentrations were determined by analyzing data as a split-plot. Performance traits were fitted to a model including the effects of IGF-I concentration, sex, location, and interactions. The IGF-I concentrations increased (P < .05) from 3 to 18 wk of age before dropping at 21 wk of age. Concentrations increased more rapidly in males than in females and differed significantly between sexes from 12 to 21 wk of age. Repeatability of IGF-I concentration was .29 +/- .02; IGF-I concentrations of samples collected at 6 wk were not correlated with those at later ages. Correlations between IGF-I concentrations of samples at later ages ranged from .27 to .51. Heritability of IGF-I concentration was .27 +/- .07. There was a tendency for weight to be affected by a sex x age interaction (P = .09). Weight of boars exceeded weight of gilts only at 21 wk (111.4 +/- 1.1 vs 107.1 +/- .8 kg). Regressions of weight on IGF-I concentrations were positive at all ages but greatest at 6 wk. The IGF-I concentration did not affect backfat thickness, longissimus area, percentage of lean, age at puberty, or litter size.
Lamberson
W R
WR
Department of Animal Sciences, University of Missouri, Columbia 65211, USA.
Safranski
T J
TJ
Bates
R O
RO
Keisler
D H
DH
Matteri
R L
RL
D000375:Aging / Q000502:physiology; D000818:Animals; D001823:Body Composition / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000502:physiology; D011247:Pregnancy; D011863:Radioimmunoassay; D012098:Reproduction / Q000502:physiology*; D012727:Sex Characteristics; D013552:Swine / Q000097:blood / Q000254:growth & development* / Q000502:physiology
D007334:Insulin-Like Growth Factor I