title: Recombinant human G-CSF-mobilized peripheral blood stem cells for second allogeneic transplant after bone marrow graft rejection in children.
abstract: Two children affected by severe aplastic anaemia and sickle cell anaemia rejected the allogeneic bone marrow transplantation from an HLA-matched unrelated volunteer and an HLA-identical sibling, respectively. In both cases a second transplant using granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC) was performed. Donors were the HLA-haploidentical mother and the same HLA-identical sibling who was employed for the first marrow allograft, respectively. Treatment with G-CSF and PBSC collection were well tolerated. Both patients had engraftment of donor haemopoiesis and did not experience severe graft-versus-host disease. These cases confirm that PBSC transplant should be considered as a feasible treatment to reverse graft failure in paediatric patients.
authors.affiliation: Department of Paediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zecca
authors.forename: C
authors.initials: C
authors.lastname: Perotti
authors.forename: P
authors.initials: P
authors.lastname: Marradi
authors.forename: D
authors.initials: D
authors.lastname: Montagna
authors.forename: G
authors.initials: G
authors.lastname: Giorgiani
authors.forename: R
authors.initials: R
authors.lastname: Balter
authors.forename: L
authors.initials: L
authors.lastname: Prete
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy*; D000755:Anemia, Sickle Cell / Q000628:therapy; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor