New delivery systems for brain tumor therapy.
Therapy of brain tumors has been limited by lack of effective methods of drug delivery. Systemic administration often fails to achieve therapeutic concentrations of drugs within intracranial tumors despite toxic systemic levels. This article discusses new methods for delivering therapeutic agents to brain tumors, including intra-arterial, intrathecal, intraventricular, and interstitial administration techniques.
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Department of Neurological Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D002330:Carmustine / Q000008:administration & dosage / Q000009:adverse effects; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004333:Drug Administration Routes; D004343:Drug Implants; D006801:Humans; D015996:Survival Rate
D000970:Antineoplastic Agents; D004343:Drug Implants; D002330:Carmustine