In vitro and in vivo antibiotic susceptibilities of ELB rickettsiae.
The activities of doxycycline, rifampin, chloramphenicol, and erythromycin against ELB rickettsiae (Rickettsia azadi) were determined by dye uptake and plaque assays. Plaque formation in Vero cells was inhibited by 0.12 microgram of doxycycline per ml. The data presented demonstrate the susceptibility of ELB rickettsiae to commonly used antibiotics for the treatment of rickettsial diseases.
Radulovic
S
S
Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore 21201, USA.
Higgins
J A
JA
Jaworski
D C
DC
Azad
A F
AF
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002701:Chloramphenicol / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004318:Doxycycline / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009499:Neutral Red; D051381:Rats; D017207:Rats, Sprague-Dawley; D012281:Rickettsia / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D009499:Neutral Red; D004917:Erythromycin; D002701:Chloramphenicol; D004318:Doxycycline; D012293:Rifampin