title: The Genexpress Index: a resource for gene discovery and the genic map of the human genome.
abstract: Detailed analysis of a set of 18,698 sequences derived from both ends of 10,979 human skeletal muscle and brain cDNA clones defined 6676 functional families, characterized by their sequence signatures over 5750 distinct human gene transcripts. About half of these genes have been assigned to specific chromosomes utilizing 2733 eSTS markers, the polymerase chain reaction, and DNA from human-rodent somatic cell hybrids. Sequence and clone clustering and a functional classification together with comprehensive data base searches and annotations made it possible to develop extensive sequence and map cross-indexes, define electronic expression profiles, identify a new set of overlapping genes, and provide numerous new candidate genes for human pathologies.
authors.affiliation: Genexpress, Centre National de la Recherche Scientifique (CNRS) UPR420, Villejuif, France. remi@pauline.vjf.inserm.fr
authors.forename: R
authors.initials: R
authors.lastname: Houlgatte
authors.forename: R
authors.initials: R
authors.lastname: Mariage-Samson
authors.forename: S
authors.initials: S
authors.lastname: Duprat
authors.forename: A
authors.initials: A
authors.lastname: Tessier
authors.forename: S
authors.initials: S
authors.lastname: Bentolila
authors.forename: B
authors.initials: B
authors.lastname: Lamy
authors.forename: C
authors.initials: C
authors.lastname: Auffray
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D002874:Chromosome Mapping / Q000379:methods*; D018076:DNA, Complementary / Q000235:genetics; D016208:Databases, Factual; D015870:Gene Expression; D005796:Genes; D005807:Genes, Overlapping; D015894:Genome, Human; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics; D018482:Muscle, Skeletal / Q000737:chemistry; D009419:Nerve Tissue Proteins / Q000235:genetics; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D012377:Rodentia; D012689:Sequence Homology, Nucleic Acid; D016324:Sequence Tagged Sites
chemical_list: D018076:DNA, Complementary; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger