The difference in hypoglycemic action between polygonati rhizoma and polygonati officinalis rhizoma.
The hypoglycemic effect of the rhizomes of Polygonatum sibricum and Polygonatum officinale (Liliaceae) was investigated in KK-Ay mice, one of the animal models of non-insulin dependent diabetes mellitus (NIDDM). The methanol extract of the rhizomes of both Polygonatum sibricum (OM) and Polygonatum officinale (IM) (800 mg/kg) reduced the blood glucose levels in KK-Ay mice 4h after intraperitoneal administration. In terms of hypoglycemic effect, the blood glucose of 1M was lower than that of OM. IM-treated mice significantly decreased the blood glucose level in an insulin tolerance test, but OM-treated mice did not change. We estimated that the hypoglycemic effect of IM raised insulin sensitivity.
Miura
T
T
Suzuka University of Medical Science and Technology, Mie, Japan.
Kato
A
A
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts