title: Radiotherapy with iodine-131 in recurrent malignant struma ovarii.
abstract: Malignant struma ovarii is a very rare disease and, therefore, there is neither common agreement on treatment regimens nor sufficient follow-up experience. We present a case of a 49-year-old woman with malignant struma ovarii of the follicular type, who received ablative radioiodine treatment after thyroidectomy and surgical removal of the primary tumour. During follow-up examinations an increasing thyroglobulin level was found, caused by a tumour relapse with suspected urinary bladder infiltration on CT and proven uptake of radioiodine on whole-body scanning with iodine-131. After administration of 6GBq 131I, complete tumour regression was achieved with no evidence of a new relapse during a 30-month follow-up period. Correspondingly, repeated thyroglobulin measurements were all negative. This case demonstrates the benefit of combined surgical and radioiodine treatment of malignant struma ovarii for both monitoring and therapy of relapse or metastases; thus, the same therapeutic regimen as is employed in primary differentiated thyroid carcinoma may be recommended.
authors.affiliation: Clinic of Nuclear Medicine, Christian-Albrechts-University of Kiel, Arnold-Heller-Strasse 9, D-24105 Kiel, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Brenner
authors.forename: K H
authors.initials: KH
authors.lastname: Bohuslavizki
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: C
authors.initials: C
authors.lastname: Sippel
authors.forename: M
authors.initials: M
authors.lastname: Clausen
authors.forename: E
authors.initials: E
authors.lastname: Henze
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D003131:Combined Modality Therapy; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D010052:Ovariectomy; D011877:Radionuclide Imaging; D013330:Struma Ovarii / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D013954:Thyroglobulin / Q000097:blood; D013965:Thyroidectomy; D001749:Urinary Bladder Neoplasms / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D013954:Thyroglobulin