title: Long-term efficacy of a new formulation of prostaglandin E1 as treatment for erectile failure.
abstract: OBJECTIVE
  We determined the long-term efficacy of intracavernous injection of a new formulation of prostaglandin E1 (Caverject) as treatment for erectile failure.
  
  
  METHODS
  A prospective study was done at a university affiliated Veterans Affairs medical center. Subjects with erectile failure received injections of prostaglandin E1 at the office and self-administered injections at home for up to 18 months.
  
  
  RESULTS
  Of 16 patients who performed home injections 15 completed 6 months and 10 completed 18 months of therapy. Patient and spousal satisfaction with intercourse was 90% for months 1 to 6, and patient satisfaction was 95% for months 7 to 18.
  
  
  CONCLUSIONS
  Prostaglandin E1 was highly effective at producing penile rigidity and an erection with satisfactory vaginal intercourse.
authors.affiliation: Division of Geriatrics Medicine, Medical College of Virginia, McGuire Veterans Affairs Medical Center, Richmond, USA.
authors.forename: M
authors.initials: M
authors.lastname: Godschalk
authors.forename: D
authors.initials: D
authors.lastname: Gheorghiu
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: P G
authors.initials: PG
authors.lastname: Katz
authors.forename: T
authors.initials: T
authors.lastname: Mulligan
mesh_terms: D000527:Alprostadil / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil