Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond.
Boado
R J
RJ
Department of Medicine, UCLA School of Medicine 90024, USA.
Kang
Y S
YS
Wu
D
D
Pardridge
W M
WM
D000818:Animals; D001483:Base Sequence; D015756:Genes, tat; D015497:HIV-1 / Q000201:enzymology; D066298:In Vitro Techniques; D008297:Male; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013462:Sulfur Radioisotopes; D013873:Thionucleotides / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution
D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; D013873:Thionucleotides