title: Neurobehavioral and neurophysiological outcome of chronic low-level tetrachloroethene exposure measured in neighborhoods of dry cleaning shops.
abstract: The effects of chronic low-level tetrachloroethene (TCE) exposure on functions of the central nervous system (CNS) were measured in subjects living in the neighborhood of dry cleaning shops with a mean residential time of 10.6 years. Neurobehavioral tests were performed using a German version of the NES battery. Additionally, a pattern reversal visual-evoked potentials (VEPs) were recorded. the mean blood TCE concentration in the subjects was 17.8 micrograms/liter and the median indoor TCE air concentration measured in the residences was 1.36 mg/m3. The outcome of the NES subtests for vigilance, simple reaction time, as well as visual memory differed statistically significantly between the exposed subjects and the controls, whereas for VEP latencies the differences were statistically not significant. It is concluded that despite the low exposure levels, CNS functions might be affected by TCE in subjects living close to a dry cleaning facility if the exposure lasts for several years.
authors.affiliation: Department of Neurotoxicology, Heinrich-Heine-University Düsseldorf, Federal Republic of Germany.
authors.forename: L
authors.initials: L
authors.lastname: Altmann
authors.forename: H F
authors.initials: HF
authors.lastname: Neuhann
authors.forename: U
authors.initials: U
authors.lastname: Krämer
authors.forename: J
authors.initials: J
authors.lastname: Witten
authors.forename: E
authors.initials: E
authors.lastname: Jermann
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis; D016902:Air Pollution, Indoor / Q000009:adverse effects / Q000032:analysis; D002490:Central Nervous System / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D015331:Cohort Studies; D004781:Environmental Exposure; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects*; D012044:Regression Analysis; D012307:Risk Factors; D012997:Solvents / Q000009:adverse effects* / Q000032:analysis; D011795:Surveys and Questionnaires; D013750:Tetrachloroethylene / Q000009:adverse effects* / Q000032:analysis / Q000097:blood
chemical_list: D000393:Air Pollutants; D012997:Solvents; D013750:Tetrachloroethylene