title: Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies.
abstract: The aim of this study was to determine whether recurrent miscarriage (three or more miscarriages, no live children) was associated with an increased incidence of autoantibodies. Five groups were enrolled into the study; healthy non-pregnant women, healthy first-trimester pregnant women, women suffering spontaneous abortion, those undergoing termination of pregnancy and those with a previous history of miscarriage. The number of total B cells and the numbers of the antibody producing B cell subset CD5+/CD20+ were determined for each group. Samples were tested for anticardiolipin antibodies, antinuclear antibodies and thyroid microsomal and thyroglobulin antibodies. The results showed that compared to normal pregnancy or spontaneous abortion, recurrent miscarriage was associated with a significant increase in the number of CD5+/20+ positive cells (0.8 +/- 0.3 vs 0.5 +/- 0.1 vs 1.1 +/- 0.3 x 10(8)/l; p < 0.001). These women were also found to have a higher incidence of thyroid antibodies, with four out of the 11 patients being positive for thyroid microsomal antibodies. These results suggest that there may be an association between autoimmunity and recurrent miscarriage.
authors.affiliation: University Department of Medicine and Obstetrics, Glasgow Royal Infirmary, UK.
authors.forename: J
authors.initials: J
authors.lastname: Roberts
authors.forename: C
authors.initials: C
authors.lastname: Jenkins
authors.forename: R
authors.initials: R
authors.lastname: Wilson
authors.forename: C
authors.initials: C
authors.lastname: Pearson
authors.forename: I A
authors.initials: IA
authors.lastname: Franklin
authors.forename: M A
authors.initials: MA
authors.lastname: MacLean
authors.forename: J H
authors.initials: JH
authors.lastname: McKillop
authors.forename: J J
authors.initials: JJ
authors.lastname: Walker
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology*; D000028:Abortion, Induced; D000328:Adult; D018951:Antigens, CD20 / Q000032:analysis*; D001323:Autoantibodies / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens / Q000032:analysis*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D011247:Pregnancy; D012016:Reference Values; D013954:Thyroglobulin / Q000276:immunology; D013974:Thyroxine / Q000097:blood
chemical_list: D018951:Antigens, CD20; D001323:Autoantibodies; D018956:CD5 Antigens; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin; D013974:Thyroxine