Can persistent cerebral damage be caused by hyperglycaemia?
An eight-year-old girl demonstrated severe and persistent neurological damage following an uneventful anaesthetic for a planned appendicectomy. The perioperative period was remarkable only in that the patient experienced very severe hyperglycaemia and an epileptiform convulsion. A possible mechanism for neurological damage as a result of severe hyperglycaemia is described.
Bush
G H
GH
Alder Hey Children's Hospital, Liverpool, UK.
Steward
D J
DJ
D000768:Anesthesia, General; D001062:Appendectomy; D002648:Child; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007430:Intraoperative Care; D007431:Intraoperative Complications / Q000209:etiology; D018458:Persistent Vegetative State / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D012640:Seizures / Q000150:complications; D012965:Sodium Chloride / Q000008:administration & dosage
D012965:Sodium Chloride; D005947:Glucose