[Evaluation of the toxic effects of cadmium on the body in light of research on the behavior of lipid compounds in aortic walls of animals].
The goal of this project was to observe certain paths of lipid metabolism in the aorta under the influence of chronic cadmium poisoning. A statistically very significant concentration of cadmium was found in the aortic walls of poisoned rats. However, the concentration of cadmium was not changed in the blood serum, where only a slight tendency towards increase was observed. Among the lipid compounds traced in the blood serum, a considerable increase in triglycerides was observed. The increase in the concentration of total cholesterol in the aortic wall was slight but statistically significant. The concentration of other analyzed lipids--i.e. free fatty acids, triglycerides and phospholipids--did not change. The above observations suggest the hypothesis of the possible development of atherosclerotic changes resulting from chronic cadmium poisoning.
Grabowska-Maślanka
H
H
Katedra Patofizjologii Collegium Medicum UJ w Krakowie.
Janik
A
A
D000818:Animals; D001011:Aorta / Q000737:chemistry*; D001161:Arteriosclerosis / Q000139:chemically induced*; D002104:Cadmium / Q000032:analysis / Q000633:toxicity*; D019256:Cadmium Chloride; D002712:Chlorides / Q000032:analysis / Q000633:toxicity*; D002784:Cholesterol / Q000032:analysis; D004730:Endothelium, Vascular / Q000737:chemistry*; D008055:Lipids / Q000032:analysis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D002712:Chlorides; D008055:Lipids; D014280:Triglycerides; D002104:Cadmium; D002784:Cholesterol; D019256:Cadmium Chloride