Estrogen-progestin therapy and coronary heart disease in radiation-induced rectal telangiectases.
We describe two elderly men with preexisting coronary heart disease (CHD) and prostatic carcinoma who presented with intractable anemia due to radiation-induced rectal telangiectases and bleeding. Remission of the bleeding was achieved in both patients by treatment with an estrogen-progestin preparation. However, aggravation of the CHD occurred in both patients. We believe that estrogen-progestin preparations have a potential in the treatment of men with radiation-induced rectal telangiectases, but additional studies are needed to evaluate their long-term effects and optimal dose.
Niv
Y
Y
Department of Gastroenterology, Soroka Medical Center, Beer-Sheva, Israel.
Henkin
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000139:chemically induced* / Q000453:epidemiology; D045166:Estradiol Congeners / Q000008:administration & dosage / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D009640:Norethindrone / Q000008:administration & dosage / Q000009:adverse effects*; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D011832:Radiation Injuries / Q000188:drug therapy*; D012002:Rectal Diseases / Q000188:drug therapy* / Q000209:etiology; D012007:Rectum / Q000098:blood supply; D013684:Telangiectasis / Q000188:drug therapy* / Q000209:etiology
D045166:Estradiol Congeners; D045167:Progesterone Congeners; D004997:Ethinyl Estradiol; D009640:Norethindrone