title: Effect of MaxEPA (fish oil) on lipoproteins and its receptors in hypercholesterolemic rabbits.
abstract: The effect of dietary MaxEPA (fish oil) supplementation on cholesterol induced hypercholesterolemia in rabbits was investigated. Rabbits were fed 0.1% cholesterol enriched diet for one month and randomly divided into two groups (I and II). Group I was continued on a 0.1% cholesterol rich diet whereas group II in addition to cholesterol supplementation received MaxEPA (2.5 g/kg body weight) per day for a period of two months. B-VLDL-C, LDL-C and total serum peroxide levels (TBARS) were significantly higher in group II animals as compared to group I. No statistical difference was found in the number of hepatic B-VLDL binding sites between group I and II. Microscopic examination of the aorta showed an increase in the number of intimal foam cells in MaxEPA treated group, a result that may be linked to increase in total cholesterol, plasma TBARS and with simultaneous reduced hepatic uptake of B-VLDL.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: C
authors.initials: C
authors.lastname: Achtani
authors.forename: A
authors.initials: A
authors.lastname: Awtade
authors.forename: S
authors.initials: S
authors.lastname: Vasisht
authors.forename: L M
authors.initials: LM
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000009:adverse effects; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004281:Docosahexaenoic Acids; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid; D015525:Fatty Acids, Omega-3 / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D005395:Fish Oils / Q000737:chemistry / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000209:etiology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011485:Protein Binding; D011817:Rabbits; D018110:Receptors, Lipoprotein / Q000378:metabolism*
chemical_list: D002791:Cholesterol, Dietary; D004042:Dietary Fats, Unsaturated; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008074:Lipoproteins; C045153:Maxepa; D018110:Receptors, Lipoprotein; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid