Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physiochemical properties and structural elucidation.
New anticell-adherence compounds, macrosphelides A and B, were isolated from the fermentation broth of Microsphaeropis sp. FO-5050, and their structures were elucidated by spectroscopic methods and chemical transformations. Macrosphelides A (M.W. 342, C16H22O8) and B (M.W. 340, C16H20O8) with three esters in their molecules were classified as 16-membered macrocyclic compounds. Macrosphelide B was found to be a corresponding oxidative product of macrosphelide A at the C-14 position.
Takamatsu
S
S
The Kitasato Institute, Tokyo, Japan.
Kim
Y P
YP
Hayashi
M
M
Hiraoka
H
H
Natori
M
M
Komiyama
K
K
Omura
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry
D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; C097798:macrosphelide A; C097799:macrosphelide B