title: A 30-Mb metric fluorescence in situ hybridization map of human chromosome 19q.
abstract: A high-resolution metric physical map of chromosome 19q has been constructed by fluorescence in situ hybridization. The map locates 136 cosmid reference points that span 30 Mb. The reference points are sequentially ordered from centromere to telomere, and the distance between neighboring cosmids is known from 240 partially overlapping, redundant estimates of genomic distances in kilobases separating pairs of cosmids. The average spacing between cosmid reference points is 220 kb, with over 75% of intervals less than 300 kb. Eighty-four genes and polymorphic markers have been assigned to mapped cosmids. The information on order and genomic distances separating pairs of cosmids, both key elements for building physical maps, has furthered the construction and integration of the genetic and physical maps of chromosome 19.
authors.affiliation: Human Genome Center, Lawrence Livermore National Laboratory, University of California, Livermore 94550, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Gordon
authors.forename: A
authors.initials: A
authors.lastname: Bergmann
authors.forename: M
authors.initials: M
authors.lastname: Christensen
authors.forename: L
authors.initials: L
authors.lastname: Danganan
authors.forename: D A
authors.initials: DA
authors.lastname: Lee
authors.forename: L K
authors.initials: LK
authors.lastname: Ashworth
authors.forename: D O
authors.initials: DO
authors.lastname: Nelson
authors.forename: A S
authors.initials: AS
authors.lastname: Olsen
authors.forename: H W
authors.initials: HW
authors.lastname: Mohrenweiser
authors.forename: A V
authors.initials: AV
authors.lastname: Carrano
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003360:Cosmids; D018076:DNA, Complementary; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011544:Pseudogenes
chemical_list: D018076:DNA, Complementary