title: A diagnostic workstation for neoplastic bone marrow diseases: evaluation on 526 cases.
abstract: The diagnostic accuracy of a workstation for neoplastic bone marrow pathology was evaluated on 526 cases from two institutions. The workstation consists of knowledge-based systems for peripheral blood analysis, flow cytometry immunophenotyping, and bone marrow morphology, linked together by a relational database. The "gold standard" diagnosis was established by complete agreement among three hematopathologists after independent review of the data from each case. The workstation's diagnosis agreed with the "gold standard" in 515 cases (97.9%). In six of the 11 diagnostic errors, the bone marrow module could not reach a final diagnosis. The five misclassifications would not have resulted in a change of therapy for the patient. The institutional diagnosis of record agreed with the gold standard in 462 cases (87.8%). The results indicate that the workstation is capable of high-quality, reproducible, multiparameter interpretive reporting.
authors.affiliation: Pathology Institute, University of Cologne, Joseph-Stelzmann Strasse 9, 50924, Cologne, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Nguyen
authors.forename: L W
authors.initials: LW
authors.lastname: Diamond
authors.forename: P
authors.initials: P
authors.lastname: Cherubino
authors.forename: W B
authors.initials: WB
authors.lastname: Koala
authors.forename: M
authors.initials: M
authors.lastname: Imbert
authors.forename: M
authors.initials: M
authors.lastname: Andreeff
mesh_terms: D000208:Acute Disease; D001185:Artificial Intelligence; D001853:Bone Marrow / Q000473:pathology*; D001855:Bone Marrow Diseases / Q000175:diagnosis; D019046:Bone Marrow Neoplasms / Q000175:diagnosis*; D003199:Computer Systems; D003936:Diagnosis, Computer-Assisted; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D006405:Hematology / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000175:diagnosis; D015203:Reproducibility of Results