title: Mercury accumulation in the squirrel monkey eye after mercury vapour exposure.
abstract: Squirrel monkeys were exposed to mercury vapour at different concentrations and for different numbers of days. The calculated total mercury absorption ranged between 1.4-2.9 mg (range of daily absorption 0.02-0.04 mg). The monkeys were killed at different intervals after the end of exposure (range 1 month - 3 years) and the eyes were enucleated. Eyes from four un-exposed monkeys were used as control material. Mapping of the mercury distribution in the eye revealed that the non-myelin-containing portion of the optic disc was densely loaded with mercury deposits, which are mostly confined to the capillary walls and the glial columns. The white matter of the brain does not accumulate mercury at these exposure levels, which might suggest that the myelinization process inhibits the accumulation of mercury. The pigmented epithelium of the pars plicata of the ciliary body and of the retina contained a considerable amount of mercury. This finding indicates that mercury is trapped within the melanocytes, which keeps potentially dangerous material from reaching the neural retina. In addition, the retinal capillary walls were densely loaded with mercury deposits, even 3 years after exposure. It was also found that the inner layers of the retina accumulated mercury during a 3-year period. It is known that the biological half-time of mercury in the brain may exceed years. This seems also to be the case for the ocular tissue.
authors.affiliation: Department of Ophthalmology, University Hospital of Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Warfvinge
authors.forename: A
authors.initials: A
authors.lastname: Bruun
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002829:Choroid / Q000378:metabolism; D002924:Ciliary Body / Q000378:metabolism; D005123:Eye / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D008628:Mercury / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009898:Optic Disk / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D012160:Retina / Q000378:metabolism; D012453:Saimiri; D014018:Tissue Distribution; D014835:Volatilization
chemical_list: D008628:Mercury