RES-1149-1 and -2, novel non-peptidic endothelin type B receptor antagonists produced by Aspergillus sp. II. Structure determination and derivatization.
The structures of two novel non-peptidic endothelin type B receptor antagonists, RES-1149-1 and -2 were determined by spectroscopic methods. Several derivatives were synthesized from RES-1149-1 for biological assay.
Uosaki
Y
Y
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Yoshida
M
M
Ogawa
T
T
Saitoh
Y
Y
D065128:Endothelin Receptor Antagonists; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D044023:Receptor, Endothelin B; D013764:Tetrahydronaphthalenes / Q000737:chemistry*
D065128:Endothelin Receptor Antagonists; C098351:RES 1149-1; C098352:RES 1149-2; D044023:Receptor, Endothelin B; D013764:Tetrahydronaphthalenes