Immunostimulatory and antitumor activities of monoglycosylceramides having various sugar moieties.
Ten kinds of monoglycosylceramides (MonoCers), having the same ceramide portion and different sugar moieties, were synthesized and their immunostimulatory and antitumor activities were examined. The manner of combination between sugar and ceramide has been demonstrated to affect the manifestation of immunostimulatory and resultant antitumor activities of MonoCers, and in the case of D-MonoCers having the D-sugar, alpha-D-MonoCers (sugar combined to ceramide in an alpha-configuration) show stronger activities than beta-D-MonoCers. Furthermore, the form of sugar, not the furanose-form but the pyranose-form, and the 2"- and 4"-hydroxyl groups of the pyranose-form of sugar, seemed to play an important role in the manifestation of the activities of alpha-D-MonoCers.
Motoki
K
K
Pharmaceutical Research Laboratory, Kirin Brewery Co., LTD., Gunma Japan.
Morita
M
M
Kobayashi
E
E
Uchida
T
T
Akimoto
K
K
Fukushima
H
H
Koezuka
Y
Y
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry; D005260:Female; D005699:Galactosylceramides / Q000737:chemistry / Q000494:pharmacology*; D005963:Glucosylceramides / Q000737:chemistry / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013154:Spleen / Q000166:cytology
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D002241:Carbohydrates; D005699:Galactosylceramides; D005963:Glucosylceramides