Granulomatous hepatitis associated with glyburide.
A wide variety of diseases and injuries can cause granulomatous hepatitis, and drug-induced granulomatous hepatitis is a well-described entity. Sulfonylurea derivatives, which are commonly used oral hypoglycemic agents in the treatment of non-insulin-dependent diabetes mellitus, have been implicated in liver disease. However, glyburide, a second-generation sulfonylurea and a potent hypoglycemic drug, is considered to have less hepatic side effects than chlorpropamide. It has been reportedly associated with cholestatic jaundice and hepatitis and with hypersensitivity angitis. A case of necrotizing granuloma has been reported. We present a second case of granulomatous hepatitis occurring in a patient who had been taking glyburide for approximately three years, and we review the literature for glyburide-associated hepatitis.
Saw
D
D
Department of Pathology, New York Hospital Medical Center of Queens, Flushing, New York 11355, USA.
Pitman
E
E
Maung
M
M
Savasatit
P
P
Wasserman
D
D
Yeung
C K
CK
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005905:Glyburide / Q000009:adverse effects*; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D007004:Hypoglycemic Agents; D005905:Glyburide