title: Case report: successful treatment with cimetidine and zinc sulphate in chronic mucocutaneous candidiasis.
abstract: The authors evaluated the clinical efficacy of a treatment with cimetidine and zinc sulphate in a patient with chronic mucocutaneous candidiasis. Cimetidine was given at a dose of 400 mg three times daily; zinc sulphate at a dose of 200 mg daily, then adjusted to maintain blood zinc levels at the upper normal range. This treatment lasted 16 months. An impressive and significant reduction of the infectious events and an increased CD4 (helper/inducer) cell counts were observed. The authors conclude that this combined immunopotentiating treatment is safe and inexpensive to treat immunodeficiency disorders.
authors.affiliation: Institute of Internal Medicine, Infectious Disease and Immunopathology, Univerity of Milan, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Polizzi
authors.forename: L
authors.initials: L
authors.lastname: Origgi
authors.forename: G
authors.initials: G
authors.lastname: Zuccaro
authors.forename: P
authors.initials: P
authors.lastname: Matti
authors.forename: R
authors.initials: R
authors.lastname: Scorza
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D018791:CD4 Lymphocyte Count / Q000187:drug effects; D002178:Candidiasis, Chronic Mucocutaneous / Q000097:blood / Q000188:drug therapy*; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D013431:Sulfates / Q000627:therapeutic use*; D017967:Zinc Compounds / Q000627:therapeutic use*; D019287:Zinc Sulfate
chemical_list: D000276:Adjuvants, Immunologic; D013431:Sulfates; D017967:Zinc Compounds; D019287:Zinc Sulfate; D002927:Cimetidine