title: Uranium skeletal dosimetry and distribution in young adult beagles: a guide for calculating uranium skeletal doses in humans.
abstract: Uranium isotopes were given via single intravenous injection into 22 young adult beagle dogs of both sexes to determine the metabolism of this element. Animals were given either 232U, 233U, 238U, or a combination of 232 (+) 233U. Calculations to assign a value of skeletal dose for each dog were performed using published radioactive properties of each uranium isotope and the metabolic data (including measured retention and skeletal distribution) derived from this study during a period of up to 2 y after injection. We believe that the procedures illustrated in this communication can serve as a useful pattern for estimating skeletal radiation doses to humans contaminated with 232U, 233U, or 238U.
authors.affiliation: University of Utah, Salt Lake City 84112, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: LLoyd
authors.forename: E
authors.initials: E
authors.lastname: Polig
authors.forename: G N
authors.initials: GN
authors.lastname: Taylor
authors.forename: F W
authors.initials: FW
authors.lastname: Bruenger
authors.forename: S C
authors.initials: SC
authors.lastname: Miller
mesh_terms: D000818:Animals; D001699:Biometry; D001842:Bone and Bones / Q000378:metabolism / Q000528:radiation effects*; D004285:Dogs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011829:Radiation Dosage; D011874:Radiometry / Q000706:statistics & numerical data; D014018:Tissue Distribution; D014501:Uranium / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D014501:Uranium