Effects of isotonic saline loading on renal tubular and neurogenic dopamine release in conscious rabbits.
1. This study was designed to investigate the effects of isotonic saline loading on renal tubular and neurogenic dopamine (DA) in conscious rabbits. 2. Isotonic saline loading did not affect mean arterial pressure, heart rate or renal blood flow but markedly increased urine volume, sodium excretion and DA excretion. 3. Renal DA spillover was not affected by venous emptying, while renal noradrenaline (NA) spillover tended to decrease during saline loading. The ratio of % renal DA spillover to % renal NA spillover increased to 2.3 +/- 0.6 (P < 0.05) 3 h after saline loading. 4. Isotonic saline loading increased renal tubular DA production but had little effect on neurogenic DA release.
Akama
H
H
Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
Noshiro
T
T
Sano
N
N
Watanabe
T
T
Trigg
L
L
Kotsonis
P
P
Majewski
H
H
McGrath
B P
BP
Miura
Y
Y
Abe
K
K
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism* / Q000652:urine; D006339:Heart Rate / Q000187:drug effects; D007552:Isotonic Solutions; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology*
D007552:Isotonic Solutions; D012965:Sodium Chloride; D012964:Sodium; D004298:Dopamine