Epidermal growth factor in acute promyelocytic leukemia treated with retinoic acid.
We studied 18 patients with acute promyelocytic leukaemia and 13 with relapsed APL. We found a significantly elevated EGF in acute leukaemia, especially in APL, being 418.59 +/- 19.2 micrograms in the 24-h urine that was much higher than that of the normal controls. When eight APL patients achieved complete remission by RA treatment, the EGF value decreased to 149.9 +/- 27.3 micrograms in the 24-h urine near to normal. In 13 patients with relapsed APL, EGF rose to 446.9 +/- 82.6 micrograms in the 24-h urine. Most interestingly, this elevated EGF could be detected before the relapse by 5 +/- 0.84 months in seven out of eight APL with relapse. We suggest that the unaccountably elevated EGF during remission period may be an indicator of the occurrence of relapse.
Wu
X
X
Shanghai Medical University, P.R. China.
Qureshi
I A
IA
Liu
H
H
Yin
J
J
Qian
X
X
Ruijie
X
X
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000652:urine*; D002454:Cell Differentiation / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007951:Leukemia, Myeloid / Q000652:urine; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000628:therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000032:analysis / Q000652:urine*; D009364:Neoplasm Recurrence, Local / Q000652:urine; D018365:Neoplasm, Residual; D015514:Oncogene Proteins, Fusion / Q000032:analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000652:urine; D012074:Remission Induction; D014212:Tretinoin / Q000627:therapeutic use*
D014408:Biomarkers, Tumor; D007155:Immunologic Factors; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D014212:Tretinoin; D004815:Epidermal Growth Factor