Interferon alpha therapy for chronic active hepatitis type C after renal transplantation and allograft rejection.
An acute type rejection episode occurred in one of two patients treated with Interferon alpha (IFN alpha) for type C hepatitis (CHC). Histopathological examination of the graft kidney revealed focal cellular infiltration and chronic transplant glomerulopathy which showed acute or chronic type rejection. In spite of bolus administration of methyl-prednisolone, the elevation of serum creatinine level continued. After administration of anti-human lymphocyte globulin (AHLG), renal function improved, but urinary protein was still positive. Another patient had no episode of rejection during or after IFN alpha therapy.
Takahara
S
S
Department of Urology, Osaka University Medical School, Japan.
Kakimoto
K
K
Kokado
Y
Y
Kameoka
H
H
Ishibashi
M
M
Kawada
S
S
Kyo
M
M
Nagano
S
S
Mikami
O
O
Okuyama
A
A
D000328:Adult; D006084:Graft Rejection; D006526:Hepatitis C / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D016896:Treatment Outcome
D016898:Interferon-alpha