Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast.
Evolutionarily conserved from yeast to man, mitogen-activated protein kinase (MAPK) pathways respond to a variety of disparate signals which induce differentiation, proliferation, or changes in intracellular enzyme regulation. Recent advances have identified two new mammalian MAPK relatives, JNK1 and p38, and the pathways which are responsible for their activation.
Waskiewicz
A J
AJ
Fred Hutchinson Cancer Research Center, Seattle, USA. awaskiew@fred.fhcrc.org
Cooper
J A
JA
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000187:drug effects / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000187:drug effects / Q000378:metabolism*; D008322:Mammals; D008934:Mitogens / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D015003:Yeasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D006360:Heat-Shock Proteins; D008934:Mitogens; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D010744:Phosphoric Monoester Hydrolases