An autosomal recessive nonsyndromic form of sensorineural hearing loss maps to 3p-DFNB6.
Autosomal recessive nonsyndromic hearing loss (ARNSHL) is the most common form of congenitally acquired inherited hearing impairment. Although numerous loci are believed to exist, only five have been identified. Using a pooled genomic DNA screening strategy, we have identified a sixth locus, DFNB6, on 3p in the interval bounded by D3S1619 and D3S1766.
Fukushima
K
K
Department of Otolaryngology, University of Iowa, Iowa City 52242, USA.
Ramesh
A
A
Srisailapathy
C R
CR
Ni
L
L
Wayne
S
S
O'Neill
M E
ME
Van Camp
G
G
Coucke
P
P
Jain
P
P
Wilcox
E R
ER
Smith
S D
SD
Kenyon
J B
JB
Zbar
R I
RI
Smith
R J
RJ
D000483:Alleles; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003241:Consanguinity; D005260:Female; D005808:Genes, Recessive; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male