title: Acute on chronic bronchitis: A model of mucosal immunology.
abstract: Acute bronchitis has been studied as a model of disturbed mucosal immunoregulation. A new hypothesis relating to the pathogenesis of acute bronchitis has been developed, based on altered host response as the prime mover. Infection-prone subjects had low levels of lysozyme. Effective oral immunization, especially if early, reduced levels of bacterial colonization. Future attention focuses on intra bronchial inflammation and its link to the host-parasite relationship.
authors.affiliation: Discipline of Pathology, Faculty of Medicine & Health Sciences, University of Newcastle, NSW, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Clancy
authors.forename: G
authors.initials: G
authors.lastname: Pang
authors.forename: M
authors.initials: M
authors.lastname: Dunkley
authors.forename: D
authors.initials: D
authors.lastname: Taylor
authors.forename: A
authors.initials: A
authors.lastname: Cripps
mesh_terms: D000208:Acute Disease; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001980:Bronchi / Q000276:immunology / Q000382:microbiology*; D001991:Bronchitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D002908:Chronic Disease; D006192:Haemophilus Infections / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology; D006790:Host-Parasite Interactions; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007114:Immunization
chemical_list: D000942:Antigens, Bacterial