Computerized microimage analysis of age-related changes of the human sinoatrial node.
This paper reports the age-related changes in the histological features of the sinoatrial node (SAN). The hearts of 106 persons dying at different ages (2 days-83 years), without clinical or pathological evidence of cardiac disease, were taken and divided into seven age-groups. Serial sections with a thickness of 2 microns, parallel to the long axis of the SAN, were prepared. Sections with the maximal area of the SAN were stained with hematoxylin/eosin (H & E) and Betty's method. The largest area of SAN were calculated by a computerized microimage analysis system. The age-related changes of the human SAN were discussed.
Luo
B
B
Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
Song
Y
Y
Zhu
J
J
Liang
S
S
Xie
J
J
Jianhua
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D012849:Sinoatrial Node / Q000033:anatomy & histology*