title: Brain imaging: reduced sensitivity of RARE-derived techniques to susceptibility effects.
abstract: OBJECTIVE
  Our goal was to evaluate the decreased sensitivity of RARE-derived pulse sequences to susceptibility effects.
  
  
  METHODS
  A variety of RARE-derived T2-weighted fast SE echo (FSE) sequences with echo trains from 6 to 16 were compared with conventional SE (CSE) sequences by means of MRI in phantoms (iron oxides), volunteers (n = 10), and patients (n = 13) with old hemorrhagic brain lesions. All experiments were performed on a 1.5 T clinical MR system (Magnetom SP 4000; Siemens AG, Erlangen, Germany) with constant imaging parameters. Contrast-to-noise ratios (CNRs) of tubes doped with iron oxides at different concentrations and brain areas with physiological iron deposition (red nucleus, substantia nigra) were calculated for CSE and FSE pulse sequences. Areas of old brain hemorrhage were analyzed for lesion conspicuity by blinded analysis with CSE as an internal standard.
  
  
  RESULTS
  CNR of iron oxide tubes (TE 90 ms, CSE 45.0 +/- 3.5, FSE 16 echo trains 28.5 +/- 3.1; p < or = 0.01) and iron-containing brain areas decreased with increasing echo trains of FSE sequences. A significantly lower number of old hemorrhagic brain lesions was visible in patients scanned with FSE sequences (6 echo trains: n = 28; 16 echo trains; n = 26) than CSE (n = 40).
  
  
  CONCLUSIONS
  Our results demonstrate that the sensitivity of RARE-derived techniques to susceptibility effects is significantly decreased compared with CSE. CSE sequences or GE sequences should still be preferred in patients with a history of seizures or intracranial hemorrhage.
authors.affiliation: Institute of Clinical Radiology, Westfalian Wilhelms-University Muenster, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Reimer
authors.forename: T
authors.initials: T
authors.lastname: Allkemper
authors.forename: G
authors.initials: G
authors.lastname: Schuierer
authors.forename: P E
authors.initials: PE
authors.lastname: Peters
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D005260:Female; D005290:Ferric Compounds / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide