Elemental imbalances in the olfactory pathway in Alzheimer's disease.
Concentrations of 11 trace elements were determined in 56 control and 98 Alzheimer's disease (AD) olfactory bulb, olfactory tract, olfactory trigone, piriform cortex and amygdala specimens by instrumental neutron activation analysis. Iron and zinc were significantly elevated and bromine was significantly depleted in olfactory regions of AD patients, compared with normal age-matched control subjects. Elevated iron could possibly play a role in neuronal degeneration in AD by enhancing reactive free radical formation.
Samudralwar
D L
DL
Department of Chemistry, University of Kentucky, Lexington 40506, USA.
Diprete
C C
CC
Ni
B F
BF
Ehmann
W D
WD
Markesbery
W R
WR
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D006801:Humans; D009410:Nerve Degeneration / Q000502:physiology; D009501:Neutron Activation Analysis; D009830:Olfactory Bulb / Q000378:metabolism; D009833:Olfactory Pathways / Q000378:metabolism*; D014131:Trace Elements / Q000378:metabolism*
D014131:Trace Elements