Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates.
The biological effects of dehydrodidemnin B(DDB), a novel depsipeptide isolated from Aplidium albicans, were studied on Ehrlich carcinoma growing in vivo and in primary cultures, and compared with those reported for Didemnin B (DB). Daily administration of DB or DDB (2.5 micrograms/mouse) almost duplicated the animal life-span and total number of tumour cells decreased by 70-90%. Results suggest a major effect of DDB when administered in the lag phase of growth. DDB behaved as a very potent inhibitor of protein synthesis; consequently, ornithine decarboxylase activity (ODC, EC 4.1.1.17) is drastically reduced by DDB-treatment.
Urdiales
J L
JL
Laboratorio de Bioquimica y Biologiá Molecular. Facultad de Ciencias. Universidad de Málaga, Spain.
Morata
P
P
Núñez De Castro
I
I
Sánchez-Jiménez
F
F
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D004790:Enzyme Induction / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000187:drug effects; D010456:Peptides, Cyclic / Q000494:pharmacology*; D013462:Sulfur Radioisotopes; D014561:Urochordata / Q000737:chemistry
D000970:Antineoplastic Agents; D047630:Depsipeptides; D009363:Neoplasm Proteins; D010456:Peptides, Cyclic; D013462:Sulfur Radioisotopes; C030051:didemnins; D009955:Ornithine Decarboxylase; C098980:plitidepsin