Impairment of mobility in endodermal cells by FAK deficiency.
Focal adhesion kinase (FAK) is a novel nonreceptor protein tyrosine kinase that localizes in focal adhesions. It is expressed in a variety of cell types, and we reported earlier that is deficiency causes a decrease of mobility in mesodermal cells with enhanced formation of focal adhesions. With embryoid bodies generated from embryonic stem cells, we also observed a decrease of mobility in FAK-deficient endodermal cells with enhanced focal adhesion formation.
Ilić
D
D
Department of Morphogenesis, Kumamoto University School of Medicine, Japan.
Kanazawa
S
S
Furuta
Y
Y
Yamamoto
T
T
Aizawa
S
S
D000818:Animals; D001483:Base Sequence; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000201:enzymology; D004707:Endoderm / Q000166:cytology* / Q000201:enzymology; D005347:Fibroblasts / Q000166:cytology / Q000201:enzymology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000172:deficiency*; D013234:Stem Cells / Q000166:cytology / Q000201:enzymology
D015815:Cell Adhesion Molecules; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496051:Ptk2 protein, mouse