title: A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3.
abstract: Chromosome 17p13.3 is frequently deleted in human ovarian carcinoma, and the 15 kb critical region of deletion may contain a tumor suppressor gene. A 2.3 kb cDNA has been identified which spans 17 kb of genomic DNA, including 8.1 kb within the critical region, and thus is a candidate tumor suppressor gene. This highly conserved gene has significant sequence similarity to a yeast gene of unknown function and to one of the yeast enzymes in the diphthamide synthetic pathway, DPH2, that has a role in global protein synthesis regulation. This gene, named DPH2L (diphthamide biosynthesis protein 2-like), is expressed in multiple tissues and stages of development.
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, MO 63110, USA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Phillips
authors.forename: M R
authors.initials: MR
authors.lastname: Zeigler
authors.forename: L L
authors.initials: LL
authors.lastname: Deaven
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics*; D005091:Exons; D005260:Female; D005784:Gene Amplification; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D010051:Ovarian Neoplasms / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D004273:DNA, Neoplasm