title: [Pathogenetic aspects of early stages of hypertension and possibilities of non-drug treatment].
abstract: A comprehensive study of young patients with early hypertensive disease (HD) has revealed their constitutional personality traits which result at long-term traumatization (in addition to exogenous stresses, there is an intrapersonal conflict) in the autonomic nervous disintegration syndrome, lowered parasympathetic effects in the presence of hypersympathicotonia. There is markedly impaired secretion in the dopaminergic link of the sympathoadrenal system along with a steady-state increase in norepinephrine:dopamine ratio, which may be regarded as a possible marker (a risk factor) of HD progression. The decreased secretion of the antistressors dopamine and beta-endorphin can also make a contribution to the progression of HD and its evolution.
authors.forename: V I
authors.initials: VI
authors.lastname: Makolkin
authors.forename: V I
authors.initials: VI
authors.lastname: Podzolkov
authors.forename: L G
authors.initials: LG
authors.lastname: Ursova
authors.forename: T D
authors.initials: TD
authors.lastname: Bol'shakova
authors.forename: T S
authors.initials: TS
authors.lastname: Mel'nikova
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004032:Diet; D004298:Dopamine / Q000378:metabolism; D004569:Electroencephalography; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D013997:Time Factors; D001615:beta-Endorphin / Q000378:metabolism
chemical_list: D001615:beta-Endorphin; D004298:Dopamine; D009638:Norepinephrine