title: [Structural disorders in the tissues of nematodes of the suborder Ascaridata after exposure to anthelmintics].
abstract: The paper analyzes the authors' original findings and the data available in the literature concerning the structural changes in the tissue of Ascaridae after exposure to anthelmintics. The subject of the study of structural changes occurring in the digestive and genital systems represented As. canis lumbricoides, Toxocara mystax, Ascaridia galli. All the anthelmintics under study were found to greatly affect their hypodermis, the wall of the middle intestine and the epithelium of various parts of the genital tubes. All the agent differently caused vacuolization and impaired the integrity of cellular organoids. The middle intestine displayed a local or complete destruction of the brush border, as well as the swelling or pyknosis of epithelial nuclei. Each anthelminthic affected the same tissue of different helminths in a different manner. The nature and magnitude of structural derangements in the digestive and genital systems of Ascaridae depended on the properties of an agent and species-specific responses of nematodes. The used anthelmintics caused only insignificant structural changes in the excretory system.
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Bogoiavlenskiĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Rachkovskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Chebyshev
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D017162:Ascaridida / Q000033:anatomy & histology / Q000187:drug effects*; D004064:Digestive System / Q000033:anatomy & histology / Q000187:drug effects; D006066:Gonads / Q000033:anatomy & histology / Q000187:drug effects; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D000871:Anthelmintics