In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells.
Differential cytokine production by gamma delta+ T cells influences Th1 and Th2 responses. Here, we describe the in vivo kinetics of peritoneal and splenic gamma delta+, CD4+, and CD8+ T cell cytokine responses during primary and secondary Listeria infections. The data show differences in the kinetics of IFN-gamma-producing alpha beta+ splenocytes consistent with immunologic memory. Most noteworthy, however, was the elevated production of IL-10 by splenic gamma delta+ T cells in the red pulp and marginal zones that coincided with maximal IFN-gamma production and with a decrease in inflammation and tissue damage. This result implies a role for gamma delta+ T cells in the control of Th1 responses.
Hsieh
B
B
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA.
Schrenzel
M D
MD
Mulvania
T
T
Lepper
H D
HD
DiMolfetto-Landon
L
L
Ferrick
D A
DA
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D007117:Immunization, Secondary; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008088:Listeriosis / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D051379:Mice; D008809:Mice, Inbred C3H; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013158:Splenic Diseases / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma