[Post-transfusion rise in thrombocytes: observations in a hematologic-oncologic patient sample].
OBJECTIVE
Aim of the present analysis was the evaluation of clinical conditions and product-specific parameters influencing posttransfusion platelet increment.


METHODS
400 single-donor platelet transfusions were analyzed for patient- and concentrate-specific factors influencing posttransfusion platelet increment. Statistical analysis was performed by the General Mixed Model Analysis of Variance.


METHODS
Department of hematology and oncology at a university hospital.


METHODS
46 patients (24 male, 22 female; age 17-80 years).


METHODS
Single-donor platelet transfusions.


RESULTS
As demonstrated earlier, splenomegaly, body temperature, and bone marrow transplantation could be proven as factors reducing posttransfusion platelet increment. In addition, hepatomegaly and application of antibiotics had negative effects on platelet increment. Among the product-specific parameters leukocyte contamination and pretransfusion storage time reduced transfusion success significantly.


CONCLUSIONS
Clinical factors influencing posttransfusion platelet increment can hardly be controlled. In contrast, concentrate-specific parameters can be influenced by preparation technique and storage procedure. Therefore, high value should be set on low leukocyte contamination and short pretransfusion storage time of platelet concentrates.
Böck
M
M
Institut für Transfusionsmedizin und Immunhämatologie, Universität Magdeburg, Deutschland.
Muggenthaler
K H
KH
Schmidt
U
U
Heim
M U
MU
Mempel
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000097:blood / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000628:therapy*; D010976:Platelet Count; D017713:Platelet Transfusion