title: Osteoinductive agents. Basic science and clinical applications.
abstract: Demineralized bone matrix (DBM) is well characterized as an osteoinductive agent. This article reviews the historical perspectives and current body of knowledge on the mechanisms of induced osteogenesis and the factors contained within DBM, which can induce bone formation. The use of DBM and osteoinductive agents to treat bone defects and nonunions in both animal models and human conditions in orthopedic and reconstructive surgery are discussed.
authors.affiliation: Department of Orthopedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Kale
authors.forename: P E
authors.initials: PE
authors.lastname: Di Cesare
mesh_terms: D000818:Animals; D001857:Bone Matrix; D019485:Bone Morphogenetic Proteins; D016723:Bone Remodeling; D018786:Bone Substitutes; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016348:Osseointegration / Q000502:physiology; D019736:Prostheses and Implants; D011506:Proteins / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D006133:Growth Substances; D011506:Proteins