Effects of an antioxidant in a rabbit model of tourniquet-induced skeletal muscle ischemia-reperfusion injury.
The purpose of this study was to evaluate the effects of U74006F, a new antioxidant, on isometric contractile function after tourniquet-induced ischemia-reperfusion injury. Twenty-six NZW rabbits underwent either 2 or 4 hr of thigh tourniquet compression. Animals were randomized to receive U74006F or an equal volume of its citrate vehicle. When tibialis anterior function was tested 2 days later, there was no difference between treatment groups in peak tension, rate of force production, contraction time, half relaxation time, or resistance to fatigue. The use of U74006F failed to improve functional outcome in this model of ischemia-reperfusion injury.
Mohler
L R
LR
Department of Orthopaedic Surgery, University of California San Diego, USA.
Pedowitz
R A
RA
Ohara
W M
WM
Oyama
B K
BK
Lopez
M A
MA
Gershuni
D H
DH
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004558:Electric Stimulation; D016166:Free Radical Scavengers / Q000494:pharmacology; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology*; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply*; D011281:Pregnatrienes / Q000494:pharmacology*; D011817:Rabbits; D015427:Reperfusion Injury / Q000503:physiopathology*; D014111:Tourniquets
D000975:Antioxidants; D016166:Free Radical Scavengers; D011281:Pregnatrienes; C053355:tirilazad