Src and the control of cell division.
The finely tuned mechanisms that control cell cycle progression go awry in cancer, pointing to proto-oncogene products as important players in cell-cycle regulation. One such proto-oncoprotein, c-Src, has previously been directly implicated, based on its requirement for growth factor-stimulated DNA synthesis. Roche et al. have now shown that c-Src or its close relatives are also required for cell division to occur. The demonstration of essential functions for the Src family at multiple points in the cell cycle raises important questions about the normal and transforming activities of these and other proto-oncoproteins.
Taylor
S J
SJ
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14851, USA.
Shalloway
D
D
D000818:Animals; D001001:Anura; D002453:Cell Cycle / Q000235:genetics; D002455:Cell Division / Q000235:genetics*; D016195:G2 Phase; D005786:Gene Expression Regulation; D016391:Genes, src; D006801:Humans; D051379:Mice; D005810:Multigene Family; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000502:physiology; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000502:physiology*; D014982:Xenopus laevis; D018909:src Homology Domains / Q000502:physiology
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)