Platelet degranulation induced by some contrast media is independent of their nonionic vs ionic nature.
We confirm that the phenomenon of platelet degranulation exists for both iohexol and diatrizoate, as reported earlier. In contrast to previous conclusions, however, we have determined that the degranulation is independent of the nonionic vs. ionic nature of the media per se, since degranulation was neither seen with nonionic iodixanol nor ionic ioxaglate. The degranulation, further, does not significantly augment platelet function, as measured by flowing whole blood platelet aggregometry.
Grabowski
E F
EF
Cardiovascular Thrombosis Laboratory, Massachusetts General Hospital-Harvard Medical School, Boston, USA.
Jang
I K
IK
Gold
H
H
Palacios
I F
IF
Boor
S E
SE
Rodino
L J
LJ
Michelson
A D
AD
D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D015550:Cell Degranulation / Q000187:drug effects*; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D007485:Ioxaglic Acid / Q000009:adverse effects / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000737:chemistry
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol; D007485:Ioxaglic Acid