title: Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil.
abstract: A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion. Measures administered to both groups included structured psychiatric diagnostic interviews, personality testing, and neuropsychological evaluation. Phenomenological assessment of the altered state experience as well as semistructured and open-ended life story interviews were conducted with the long-term use hoasca group, but not the hoasca-naive control group. Salient findings included the remission of psychopathology following the initiation of hoasca use along with no evidence of personality or cognitive deterioration. Overall assessment revealed high functional status. Implications of this unusual phenomenon and need for further investigation are discussed.
authors.affiliation: Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, California, 90509, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Grob
authors.forename: D J
authors.initials: DJ
authors.lastname: McKenna
authors.forename: J C
authors.initials: JC
authors.lastname: Callaway
authors.forename: G S
authors.initials: GS
authors.lastname: Brito
authors.forename: E S
authors.initials: ES
authors.lastname: Neves
authors.forename: G
authors.initials: G
authors.lastname: Oberlaender
authors.forename: O L
authors.initials: OL
authors.lastname: Saide
authors.forename: E
authors.initials: E
authors.lastname: Labigalini
authors.forename: C
authors.initials: C
authors.lastname: Tacla
authors.forename: C T
authors.initials: CT
authors.lastname: Miranda
authors.forename: R J
authors.initials: RJ
authors.lastname: Strassman
authors.forename: K B
authors.initials: KB
authors.lastname: Boone
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D003071:Cognition / Q000187:drug effects; D006213:Hallucinogens / Q000494:pharmacology*; D006247:Harmine / Q000494:pharmacology; D006801:Humans; D008273:Magic; D008297:Male; D008519:Medicine, Traditional; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010551:Personality / Q000187:drug effects; D010946:Plants, Medicinal; D011569:Psychiatric Status Rating Scales; D012068:Religion and Medicine; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology; D013662:Tea; D014706:Verbal Learning / Q000187:drug effects
chemical_list: D006213:Hallucinogens; D013662:Tea; D006247:Harmine