title: Localization of the Darier disease gene to a 2-cM portion of 12q23-24.1.
abstract: Positional cloning with microsatellite markers allowed further localization of the Darier disease gene to a 2-cM interval of chromosome 12, 12q23-24.1, between the polymorphic loci D12S234 and D12S129. A region this size is suitable for construction of a contig to identify the Darier disease gene. Use of a polymorphic intronic marker for nitric oxide synthetase 1 gene, which maps to the same chromosomal area as the Darier gene, allowed exclusion of that gene as the Darier disease gene.
authors.affiliation: Department of Dermatology, University of Rochester, NY 14642, USA.
authors.forename: P
authors.initials: P
authors.lastname: Wakem
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Haake
authors.forename: R
authors.initials: R
authors.lastname: Polakowska
authors.forename: N
authors.initials: N
authors.lastname: Ewing
authors.forename: Y
authors.initials: Y
authors.lastname: Sarret
authors.forename: M
authors.initials: M
authors.lastname: Duvic
authors.forename: D
authors.initials: D
authors.lastname: Berg
authors.forename: A
authors.initials: A
authors.lastname: Bassett
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: A
authors.initials: A
authors.lastname: Tuskis
authors.forename: E H
authors.initials: EH
authors.lastname: Epstein
authors.forename: L A
authors.initials: LA
authors.lastname: Goldsmith
mesh_terms: D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D007644:Darier Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree