A single element mediates glucocorticoid hormone response of HPV18 with no functional interactions with AP1 or hbrm.
We determined that the human papillomavirus type 18 (HPV18) regulatory region contains one functional GRE sequence that interacts with the glucocorticoid receptor. This sequence conferred a moderate hormonal activation to the HPV18 P105 promoter. Two modulators of glucocorticoid hormone activity, AP1 and hbrm, both involved in P105 transcription, were found not to interfere with this hormonal activation.
Medina-Martinez
O
O
Departamento de Biologia Molecular, Instituto de Investigaciones Biomédicas-UNAM, Mexico.
Morales-Peza
N
N
Yaniv
M
M
García-Carrancá
A
A
Thierry
F
F
D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D016384:Consensus Sequence; D004279:DNA, Viral / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D005938:Glucocorticoids / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D027383:Papillomaviridae / Q000235:genetics*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D012045:Regulatory Sequences, Nucleic Acid; D018808:Transcription Factor AP-1 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D004279:DNA, Viral; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; C084011:SMARCA2 protein, human; D018808:Transcription Factor AP-1; D014157:Transcription Factors