title: Octreotide and heater probe thermocoagulation for arrest of peptic ulcer hemorrhage. A prospective, randomized, controlled trial.
abstract: We carried out a prospective, randomized, controlled trial over a 7-month period to assay the hemostatic effects of octreotide and heater probe thermocoagulation (HPT) in 54 patients with active peptic ulcer bleeding or nonbleeding visible vessels at the ulcer base. Nineteen patients received octreotide 100 micrograms bolus i.v. followed by 25 micrograms/h i.v. for 3 days. Twenty patients received HPT. Fifteen patients received ranitidine 100 mg i.v. every 12 h. The three groups were matched for sex, age, location of bleeders, endoscopic findings, shock, and initial hemoglobin. Ultimate hemostasis was obtained in 11 (58%) of the octreotide group, 18 (90%) of the heater probe group, and 8 (53%) of the control group (p < 0.05). Volume of blood transfused, number of patients receiving operation, hospital stay, and number of deaths were not statistically significant among the three groups. We conclude that HPT is more effective than octreotide in the arrest of peptic ulcer bleeding.
authors.affiliation: Department of Internal Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lin
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.forename: C L
authors.initials: CL
authors.lastname: Perng
authors.forename: R T
authors.initials: RT
authors.lastname: Chua
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
mesh_terms: D000368:Aged; D004564:Electrocoagulation; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies
chemical_list: D005765:Gastrointestinal Agents; D006490:Hemostatics; D015282:Octreotide