Interleukin-1 inhibits sexual behavior in female but not in male rats.
The cytokine interleukin-1 (IL-1) is released by a variety of cells in response to infection or injury. IL-1 produces several neuroendocrine and behavioral effects, including a suppression of reproductive functions and goal-directed behaviors. The present study examined the effect of IL-1 on sexual behavior in male and female rats. The following behavioral tests were employed: preference for a sexually appropriate partner, proceptive (soliciting) behavior, the lordosis quotient (sexual receptivity), and mating performance. Peripheral (ip) IL-1 beta, 2 or 10 micrograms/kg, injected 2 h before testing, significantly suppressed proceptive behavior and sexual receptivity in intact, normally cycling females. In ovariectomized rats treated with ovarian hormones, IL-1 beta (2 or 10 micrograms/kg) significantly decreased the preference for a sexually active male partner and suppressed proceptive behavior and sexual receptivity. These effects were evident 2, but not 4 or 6, h after IL-1 beta administration. Intracerebroventricular administration of IL-1 beta (10 ng/rat) also suppressed the preference for a male partner and proceptive behavior in normally cycling females. Similar doses of IL-1 beta had no suppressive effect on any aspect of male sexual behavior, and the highest dose even increased the preference for a receptive female partner. In contrast to the gender-specific effects on sexual behavior, the suppressive effects of IL-1 beta on activity in the open-field test were comparable in male and female rats. The inhibition of female sexual behavior by IL-1 may be adaptive, in that it prevents conception while the animal is sick, thus reducing the risk of spontaneous abortion or abnormal development.
Yirmiya
R
R
Department of Psychology, Hebrew University of Jerusalem, Mount Scopus, Israel.
Avitsur
R
R
Donchin
O
O
Cohen
E
E
D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D010052:Ovariectomy; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D007375:Interleukin-1