The instructive role of innate immunity in the acquired immune response.
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.
Fearon
D T
DT
Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, UK.
Locksley
R M
RM
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007110:Immunity, Active / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D007167:Immunotherapy; D007239:Infections / Q000276:immunology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D016207:Cytokines