Increase of survival of dopaminergic neuroblastoma in co-cultures with C-6 glioma by R-(-)-deprenyl.
We have observed that the survival of dopamine neuroblastoma (SH-SY5Y) cells in co-cultures with C-6 glioma in serum-deprived media is slightly but significantly enhanced by R-(-)-deprenyl, a selective monoamine oxidase B inhibitor. This drug, however, does not directly affect the viability of SH-SY5Y cells or glioma cells in serum or serum-deprived media. The results suggest that R-(-)-deprenyl enhances astroglial trophic support in favor of neuronal survival.
Zuo
D
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Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.
Yu
P H
PH
D001932:Brain Neoplasms / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D009447:Neuroblastoma / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology; D012642:Selegiline / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D012642:Selegiline; D016627:Oxidopamine; D004298:Dopamine