Efficacy of oral citrate administration in primary hyperoxaluria.
Urinary citrate is a potent inhibitor of calcium oxalate (CaOx) crystallization, but oral citrate has rarely been used in patients with primary hyperoxaluria (PH). We studied the effect of sodium citrate administration (0.1-0.15 g/kg/day) on urinary citrate excretion and CaOx saturation in seven paediatric patients and the clinical response to long-term treatment (average 4 years) in five patients. Urinary citrate increased from 0.73 to 2.54 mmol/24 h/1.73 m2 and urinary saturation for CaOx (calculated by equil 2) decreased from 11.41 to 6.79 (for both, p < 0.02). Long-term administration of alkali citrate [0.15 g (0.5 mmol)/kg/day] resulted in stable or improved renal function in three and slow deterioration in two partially non-compliant patients. Alkali citrate is effective in patients with PH.
Leumann
E
E
University Children's Hospital, Zurich, Switzerland.
Hoppe
B
B
Neuhaus
T
T
Blau
N
N
D000284:Administration, Oral; D000293:Adolescent; D002129:Calcium Oxalate / Q000652:urine; D002648:Child; D002675:Child, Preschool; D002951:Citrates / Q000627:therapeutic use* / Q000652:urine; D019343:Citric Acid; D005260:Female; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D007668:Kidney / Q000503:physiopathology; D008297:Male; D016896:Treatment Outcome
D002951:Citrates; D002129:Calcium Oxalate; D019343:Citric Acid