Neuropeptide Y injection into the fourth cerebroventricle stimulates c-Fos expression in the paraventricular nucleus and other nuclei in the forebrain: effect of food consumption.
Injection of neuropeptide Y (NPY) into the cerebroventricular system of the rat results in a robust feeding response. In this study, we observed that NPY injection into the fourth ventricle augmented feeding and Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) and in other neighboring nuclei in the forebrain previously implicated in stimulation of feeding. Since the rostral transport of NPY in cerebrospinal fluid after injection into the fourth ventricle is unlikely and the topography of FLI as well as feeding behavior seen in this study are similar to those observed previously after NPY injection into the lateral cerebroventricle, these findings are in accord with the view that feeding induced by NPY injection into the fourth ventricle may also be mediated by NPY receptive elements in the forebrain.
Xu
B
B
Department of Psychology, University of Florida, Gainesville 32611, USA.
Li
B H
BH
Rowland
N E
NE
Kalra
S P
SP
D000704:Analysis of Variance; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009478:Neuropeptide Y / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism; D016548:Prosencephalon / Q000187:drug effects* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D016760:Proto-Oncogene Proteins c-fos