title: Human pericardial fluid contains the highest amount of endothelin-1 of all mammalian biologic fluids thus far tested.
abstract: Immunoreactive endothelin-1 (ET-1) levels were measured in the pericardial fluid (PF), plasma (PL), and atrial and ventricular tissues of 16 cardiac surgical patients. ET-1 was higher in the PF (73 +/- 11 pg/ml) than in the PL/3.33 +/- 0.51 pg/ml; p < 0.05/. PF/PL ratio ranged from 8 to as high as 200. An inverse relationship was found between the NYHA stage and ET-1 concentrations in PF, whereas ET-1 in PL did not have any relation to the NYHA stage of the disease. In HPLC analysis, the total immunoreactive ET-1 in PF from five different patients co-eluted with the human ET-1 standard. The results indicate that ET-1 concentrations in human PF can be several-fold those in the PL. The source and function of the ET-1 in PF requires further investigation.
authors.affiliation: Department of Cardiovascular Surgery, Semmelweis Medical University, Budapest, Hungary.
authors.forename: F
authors.initials: F
authors.lastname: Horkay
authors.forename: M
authors.initials: M
authors.lastname: Laine
authors.forename: I
authors.initials: I
authors.lastname: Szokodi
authors.forename: J
authors.initials: J
authors.lastname: Leppäluoto
authors.forename: O
authors.initials: O
authors.lastname: Vuolteenaho
authors.forename: H
authors.initials: H
authors.lastname: Ruskoaho
authors.forename: A
authors.initials: A
authors.lastname: Juhász-Nagy
authors.forename: M
authors.initials: M
authors.lastname: Tóth
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D016232:Endothelins / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000737:chemistry*
chemical_list: D016232:Endothelins