Assessment of liver iron overload by T2-quantitative magnetic resonance imaging: correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis.
OBJECTIVE
To correlate hepatic 1/T2 values obtained by means of a T2-Quantitative MRI (T2-QMRI) technique with three widely applied methods for the evaluation of hemosiderosis, i.e., (a) liver iron concentrations (LFeC) (b) serum ferritin (SF), and (c) histologic grading of siderosis. The impact of coexisting hepatitis was also considered. T2-QMRI measurements were compared with signal intensity (SI) ratio measurements on conventional SE images.


METHODS
Liver T2 relaxation times were calculated in 40 thalassemic patients, on a 0.5 T magnetic resonance imaging system using a multiple spin-echo sequence with parameters: TR = 2500 ms, TE = 12 ms in 20 symmetrically repeatable echoes.


RESULTS
(a) 1/T2 values were well correlated (r = 0.97) with liver iron concentrations, which ranged from 2.32 to 18.0 mg/g dry weight (normal < 1.6 mg/g). (b) 1/T2 values were also correlated with serum ferritin levels (r = 0.84). At various 1/T2 values, serum ferritin levels were higher for the anti-HCV(+) patients than the anti-HCV(-) ones. (c) T2 values corresponding to successive grades of siderosis presented statistically significant differences. (d) SI ratio measurement assigned less statistically significant results, as compared to T2 values.


CONCLUSIONS
T2-QMRI measurement of T2 relaxation time is more accurate than SI ratios in evaluating liver iron overload. It is particularly useful for hemosiderotic patients with coexisting hepatitis since, in this case, serum ferritin is not considered a reliable index of hemosiderosis.
Papakonstantinou
O G
OG
Department of Diagnostic Radiology, University of Athens, Areteion Hospital, Greece.
Maris
T G
TG
Kostaridou
V
V
Gouliamos
A D
AD
Koutoulas
G K
GK
Kalovidouris
A E
AE
Papavassiliou
G B
GB
Kordas
G
G
Kattamis
C
C
Vlahos
L J
LJ
D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D005293:Ferritins / Q000097:blood*; D006486:Hemosiderosis / Q000175:diagnosis* / Q000209:etiology; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D016014:Linear Models; D008099:Liver / Q000737:chemistry / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015999:Multivariate Analysis; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy
D005293:Ferritins