title: Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?
abstract: Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.
authors.affiliation: Department of Biophysics, University Medical School of Debrecen, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Vereb
authors.forename: L
authors.initials: L
authors.lastname: Mátyus
authors.forename: L
authors.initials: L
authors.lastname: Bene
authors.forename: G
authors.initials: G
authors.lastname: Panyi
authors.forename: Z
authors.initials: Z
authors.lastname: Bacsó
authors.forename: M
authors.initials: M
authors.lastname: Balázs
authors.forename: J
authors.initials: J
authors.lastname: Matkó
authors.forename: J
authors.initials: J
authors.lastname: Szöllösi
authors.forename: R
authors.initials: R
authors.lastname: Gáspár
authors.forename: S
authors.initials: S
authors.lastname: Damjanovich
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D017252:CD3 Complex; D002450:Cell Communication; D004735:Energy Transfer; D005434:Flow Cytometry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D008285:Major Histocompatibility Complex; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D011956:Receptors, Cell Surface; D015375:Receptors, Interleukin-2 / Q000502:physiology
chemical_list: D000954:Antigens, Surface; D017252:CD3 Complex; D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1