Potential carcinogenicity of homoisoflavanoids and flavonoids from Resina sanguinis draconis (Dracaena cinnabari Balf.).
Polarographic behavior of three homoisoflavanoids and four flavanoids isolated from the dragon's blood (Resina sanguinis draconis. Dracaena cinnabari Balf.), collected at Sokotra, was investigated in aprotic solution and an index of potential carcinogenicity tg alpha was determined. Generally, homoisoflavanoids and flavanoids were reduced in two two-electron steps, the first being reversible and the second one irreversible. The parameter tg alpha values indicated that the majority of these compounds possesses no or only marginal potential carcinogenic activity. However, it was demonstrated that some structural modifications in basic flavonoid structure lead to changed electrochemical properties and a substantial increase of derivative potential carcinogenicity.
Vachálková
A
A
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
Novotný
L
L
Nejedlíková
M
M
Suchý
V
V
D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D005419:Flavonoids / Q000737:chemistry / Q000633:toxicity*; D007529:Isoflavones / Q000737:chemistry / Q000633:toxicity*; D010946:Plants, Medicinal / Q000737:chemistry*; D011048:Polarography; D012116:Resins, Plant / Q000737:chemistry; D013329:Structure-Activity Relationship
D002273:Carcinogens; D005419:Flavonoids; D007529:Isoflavones; D012116:Resins, Plant