title: On the nature of the adaptive response induced by mitomycin C in Vibrio cholerae OGAWA 154 cells.
abstract: The induction of an adaptive response in Vibrio cholerae OGAWA 154 cells was obtained using an alkylating agent, mitomycin C, as both stimulating and challenging agent. Cross-adaptive response was observed in V. cholerae cells when pretreated with a sublethal dose of another alkylating agent, N-methyl-N'nitro-N-nitrosoguanidine, followed by challenging treatment with mitomycin C. The dose of mitomycin C for 50% survival (D50) became almost double for mitomycin C pretreated cells and 1.5 times for N-methyl-N-'nitro-N-nitrosoguanidine pretreated cells, compared to nonpretreated cells. It was also shown that pretreatment with a sublethal dose of oxidative DNA damaging agents, viz, hydrogen peroxide or nitrofurantoin, did not show any cross-adaptive response against subsequent challenge by mitomycin C.
authors.affiliation: Biophysics Laboratory, Saha Institute of Nuclear Physics, Calcutta, India.
authors.forename: J
authors.initials: J
authors.lastname: Basak
mesh_terms: D000064:Acclimatization; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007700:Kinetics; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D016685:Mitomycin / Q000494:pharmacology*; D009582:Nitrofurantoin / Q000494:pharmacology; D013997:Time Factors; D014734:Vibrio cholerae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development
chemical_list: D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D008769:Methylnitronitrosoguanidine; D016685:Mitomycin; D009582:Nitrofurantoin; D006861:Hydrogen Peroxide