Second-trimester pregnancy loss is associated with activated C resistance.
We have investigated whether activated protein C resistance (APCR) is associated with second-trimester miscarriage. The prevalence of APCR was significantly higher amongst women with a history of second-trimester miscarriage (10/50; 20%) compared with either women with a history of first-trimester miscarriages only (4/70; 5.7%) or a control group of parous women with no previous history of pregnancy losses (3/70; 4.3%) (P < 0.02). These results suggest that APCR may be an important mechanism of second-trimester pregnancy loss, possibly related to the increase in intravascular coagulation that occurs during pregnancy.
Rai
R
R
Department of Obstetrics and Gynaecology, St Mary's Hospital, London.
Regan
L
L
Hadley
E
E
Dave
M
M
Cohen
H
H
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D005260:Female; D006801:Humans; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D013927:Thrombosis / Q000150:complications*