Synthesis and properties of novel block copolymers containing poly(lactic-glycolic acid) and poly(ethyleneglycol) segments.
A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.
Ferruti
P
P
Dipartimento di Chimica e Fisica per i Materiali, Università di Brescia, Italy.
Penco
M
M
D'Addato
P
P
Ranucci
E
E
Deghenghi
R
R
D001672:Biocompatible Materials / Q000592:standards; D001673:Biodegradation, Environmental; D006900:Hydroxylation; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D010705:Phosgene / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D001672:Biocompatible Materials; D011108:Polymers; D010705:Phosgene; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols