title: Clinical research in aggressive patients, pitfalls in study design and measurement of aggression.
abstract: 1. Experience from scale validation studies and from controlled drug trials provided clues for optimalisation of studies in aggressive patients. 2. Definitions of target behaviour, selection of patients and measurement of aggression are reviewed and recommendations are presented.
authors.affiliation: Clinical Pharmacology Department, Solvay Duphar, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Mak
authors.forename: P
authors.initials: P
authors.lastname: De Koning
mesh_terms: D000374:Aggression / Q000523:psychology*; D006801:Humans; D011569:Psychiatric Status Rating Scales; D012107:Research Design; D013223:Statistics as Topic