title: The effect of Ambroxol on bleomycin-induced changes in phospholipid composition of rat lung surfactant.
abstract: The influence of Ambroxol on bleomycin-induced changes in lung surfactant phospholipid composition in rats was examined. Bleomycin alone (intratracheally 10 mg/kg, single dose) produces a significant fall in phosphatidylcholine (especially in disaturated species) and phosphatidylglicerol content in both lavage and postlavaged lung tissues surfactants. Ambroxol (8 days, 2 mg/kg s.c. per day) normalizes these changes. Thus, Ambroxol has an salutary effect on bleomycin-induced changes in lung surfactant phospholipids.
authors.affiliation: I Clinic of General Surgery, Medical Academy, Lublin, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Stettner
authors.forename: A
authors.initials: A
authors.lastname: Ledwozyw
mesh_terms: D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001992:Bronchoalveolar Lavage Fluid; D005100:Expectorants / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D005100:Expectorants; D010743:Phospholipids; D011506:Proteins; D011663:Pulmonary Surfactants; D001761:Bleomycin; D000551:Ambroxol