Familial aspects of Caffey's disease.
Caffey's disease is a cortical hyperostosis, which presents during infancy. Etiology remains unclear. Familial occurrence has been documented in the literature. Reported here is infantile cortical hyperostosis that occurred in a father and his two daughters. The familial occurrence would suggest a genetic basis for Caffey's disease; however, it remains consistent with infection by an agent with a long latency period as has been strongly suggested in Paget's disease.
Bernstein
R M
RM
Department of Orthopaedics, University of California-Los Angeles, USA.
Zaleske
D J
DJ
D005260:Female; D006801:Humans; D006958:Hyperostosis, Cortical, Congenital / Q000000981:diagnostic imaging / Q000235:genetics*; D007223:Infant; D011859:Radiography