title: Effects of orthotopic cardiac transplantation on structural microangiopathy and abnormal hemodynamics in idiopathic dilated cardiomyopathy.
abstract: To examine whether cardiac transplantation would reverse morphologic and hemodynamic changes in peripheral circulation in idiopathic dilated cardiomyopathy, the structure of terminal arterioles and minimal vascular resistance were measured in skin at the dorsum of the foot in the same 14 patients before and 80 +/- 21 (mean +/- SD) days and 387 +/- 46 days after transplantation. The results were compared with data from a group of 16 healthy subjects. Blood flow was measured by the local technetium-99m pertechnetate washout method in a vascular bed relaxed with histamine. Structural microangiopathy (enhanced thickening of the basement membranes) in the arterioles was disclosed in skin biopsies in 11 of 14 patients before transplant, but in none of the 16 control subjects (p < 0.002). These abnormalities were unchanged 80 days after cardiac transplantation. However, arteriolar wall thickening was significantly reduced over the 1-year period after transplantation (p < 0.05), but this was not complete. Transplantation also led to a significant delayed decrease in minimal vascular resistance: before transplantation, 10.1 +/- 3.2 mm Hg.ml-1.100 g.min (mean +/- SD); 80 days after transplantation, 9.3 +/- 3.1 mm Hg.ml-1.100 g.min (p = NS), and 1 year after transplantation 7.6 +/- 2.4 mm Hg.ml-1 100 g.min (p < 0.01). Minimal vascular resistance before and 80 days after transplantation was significantly increased compared with that in healthy control subjects (6.3 +/- 1.7 mm Hg.ml-1 100g.min [p < 0.0003 and p < 0.003, respectively]). However, 1 year after transplantation, minimal vascular resistance was reduced to comparable levels when compared with that in control subjects (p = NS). These results indicate that structural microangiopathy and minimal vascular resistance in skin are improved slowly and gradually within the first year after orthotopic cardiac transplantation in patients with idiopathic dilated cardiomyopathy, however, the remodeling of histopathology is not accompanied by complete normalization.
authors.affiliation: Medical Department B 2142, Rigshospitalet, National University Hospital, University of Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Wroblewski
authors.forename: J H
authors.initials: JH
authors.lastname: Sindrup
authors.forename: T
authors.initials: T
authors.lastname: Nørgaard
authors.forename: S
authors.initials: S
authors.lastname: Haunsø
authors.forename: J
authors.initials: J
authors.lastname: Kastrup
mesh_terms: D000328:Adult; D001160:Arterioles / Q000473:pathology; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000098:blood supply; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D012044:Regression Analysis; D012867:Skin / Q000098:blood supply*; D014655:Vascular Resistance