Increase in oxygen tension after intraperitoneal N-methyl-DL-aspartate in rat cerebral cortex.
An oxygen electrode equipped with a thermocouple enabled us to determine the absolute oxygen tension (PO2) in brain regions by taking account of local changes in temperature. Under urethane anesthesia, the PO2 of rat cerebral cortex was significantly increased up to 90 min after N-methyl-DL-aspartate administration (200 mg/kg, i.p.). This suggests that stimulation of NMDA receptors enhances oxygen supply to the cerebrum in vivo.
Hara
S
S
Department of Forensic Medicine, Tokyo Medical College, Japan.
Mukai
T
T
Kuriiwa
F
F
Iwata
N
N
Kano
S
S
Endo
T
T
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D008839:Microelectrodes; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013696:Temperature
D018690:Excitatory Amino Acid Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D010100:Oxygen