title: Enhanced activity of the combination of penicillin G and gentamicin against penicillin-resistant viridans group streptococci.
abstract: We evaluated the effects of the combination of penicillin G and gentamicin against 10 penicillin-resistant bacteremic isolates of viridans group streptococci for which the MICs of penicillin were 4 to 64 micrograms/ml. In time-kill studies, the combination resulted in more killing of eight isolates for which the MICs of penicillin were from 8 to 64 micrograms/ml than any of the antimicrobial agents tested alone. In general, clearly enhanced antimicrobial activity was observed with the combination.
authors.affiliation: Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Cercenado
authors.forename: M D
authors.initials: MD
authors.lastname: Díaz
authors.forename: C
authors.initials: C
authors.lastname: Sánchez-Carrillo
authors.forename: T
authors.initials: T
authors.lastname: Vicente
authors.forename: J C
authors.initials: JC
authors.lastname: Bernaldo de Quirós
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects*; D013298:Streptococcus sanguis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D010400:Penicillin G