Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124).
Monoclonal antibody MR6 detects gp200-MR6, a molecule functionally associated with the interleukin 4 (IL- 4) receptor. Positive immunolabeling with MAb MR6 was obtained in 28/28 transitional cell carcinomas of the bladder, representing a range of different grades and stages of disease, as well as in all control non-neoplastic urothelia. The expression of mutant p53 protein and epidermal growth factor receptor was detected in 14/28 and 20/28 cases respectively. Proliferation indices, determined by Ki67 labeling, ranged from 5% to 95% among these tumours. The universal expression of gp200-MR6 in neoplastic and non-neoplastic urothelium has important implications for the possible use of IL-4 in tumour therapy and suggests that IL- 4 may play a role in differentiation and homeostasis of urothelium and other mucosal epithelia.
Tungekar
M F
MF
Division of Histopathology, United Medical and Dental Schools of Guy's and St Thomas' Hospitals Trust, London, UK.
Gatter
K C
KC
Ritter
M A
MA
D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000096:biosynthesis* / Q000276:immunology; D000954:Antigens, Surface / Q000096:biosynthesis / Q000276:immunology; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D004848:Epithelium / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006023:Glycoproteins / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type; D015778:Minor Histocompatibility Antigens; D009361:Neoplasm Invasiveness; D011956:Receptors, Cell Surface; D018123:Receptors, Interleukin / Q000378:metabolism*; D019948:Receptors, Interleukin-4; D001743:Urinary Bladder / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; C093569:DEC-205 receptor; D006023:Glycoproteins; D037181:Lectins, C-Type; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface; D018123:Receptors, Interleukin; D019948:Receptors, Interleukin-4