Effects of stress on neurotrophic factor expression in the rat brain.
Changes in neurotrophic factor expression in the brain are part of the stress response. Decreased BDNF may contribute to hippocampal damage that occurs during chronic stress or aging. Stress-induced increases in NT-3 may be important for neural plasticity and adaptation or sensitization to repeated stress. Stress-induced changes in neurotrophic factors may be particularly relevant to the cognitive changes that occur in recurrent depression, aging, and posttraumatic stress disorder.
Smith
M A
MA
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Makino
S
S
Kvetnanský
R
R
Post
R M
RM
D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor; D018891:Dentate Gyrus / Q000378:metabolism; D005938:Glucocorticoids / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020933:Neurotrophin 3; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D019208:Brain-Derived Neurotrophic Factor; D005938:Glucocorticoids; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3