title: The acute toxicity of Riedeliella graciflora in laboratory animals.
abstract: Riedeliella graciflora is a plant mainly found in southeast South America and related to bovine mortality in Sao Paulo State, Brazil. Our laboratory showed that cattle intoxicated with 10 g R graciflora leaves/kg had organ congestion, edema and hemorrhage. The aim of this study was to determine which laboratory animal species would present the same lesions found in cattle. We also studied the effects of administering parts of the fruits or leaves po, sc, ip or im. All the laboratory species developed organ congestion, edema and hemorrhage and severe nephrosis regardless which plant part was given or the route of administration used. The effects were more intense in animals dosed with R graciflora fruits ip.
authors.affiliation: Laboratory of Animal Pathology, Faculty of Veterinary Medicine, University of Sao Paulo, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Dagli
authors.forename: E A
authors.initials: EA
authors.lastname: Perrone
authors.forename: M
authors.initials: M
authors.lastname: Haraguchi
authors.forename: S L
authors.initials: SL
authors.lastname: Gorniak
authors.forename: A
authors.initials: A
authors.lastname: Hara
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001938:Brazil; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology / Q000401:mortality*; D006224:Cricetinae; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D018515:Plant Leaves / Q000378:metabolism; D010939:Plant Poisoning / Q000401:mortality / Q000662:veterinary*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D010936:Plant Extracts