MnPcS4: a new MRI contrast enhancing agent for tumor localisation in mice.
Manganese-tetrasulfonated phthalocyanine (MnPcS4) has been evaluated as a potential contrast agent in Magnetic resonance imaging (MRI) for tumor localisation in mice. MnPcS4 showed favourable molar relaxivity, much better than Gd-DTPA and comparable to tetrasulfonated manganese complex of porphyrin (TPPS4). Tumors showed selective retention of the metal complex (dye) with the peak value reached at 24 hours following intravenous administration. Dye concentration in tumors remained consistently higher than either kidney or muscle tissue both at 1 and 24 hours and a 10-fold increase in tumor-to-muscle ratio over the control was seen at 24 hr. Normal liver tissue, however, showed higher concentration than tumor at all times during the study. A linear correlation was found between longitudinal relaxation rate (1/T1) and the corresponding concentration of MnPcS4 in various tissues. MR imaging done in animals using 1.5 T superconducting clinical imager showed a mean percent increase in signal intensity of 131.8% (SD +/- 32.86) in the tumor and a 70% increase in tumor-to-muscle ratio over the pretreatment value, at 24 hr. The results suggest that MnPcS4 is a potential tumor-selective contrast agent in MRI.
Saini
S K
SK
Institute of Nuclear Medicine and Allied Sciences, Lucknow Marg, Delhi, India.
Jena
A
A
Dey
J
J
Sharma
A K
AK
Singh
R
R
D000818:Animals; D003287:Contrast Media; D005260:Female; D007211:Indoles / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis*; D008345:Manganese / Q000493:pharmacokinetics; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D007211:Indoles; D009942:Organometallic Compounds; D008345:Manganese; C052739:manganese tetrasulfophthalocyanine