Cutaneous metastasis of chordoma.
A chordoma metastatic to the skin of the nose is reported. The patient (a 40-year-old man) had undergone excision of a sacral chordoma 16 months previously. In patients whose clinical histories are unknown, cutaneous metastases of chordoma can be confused with mixed tumors of sweat glands. Cytological features, including the presence of physaliphorous cells, and immunohistochemical coexpression of low molecular weight keratins and S-100 protein are helpful features that lead to a correct diagnosis.
Cesinaro
A M
AM
Istituto di Anatomia e Istologia Patologica, Universitá di Modena, Italy.
Maiorana
A
A
Annessi
G
G
Collina
G
G
D000328:Adult; D002817:Chordoma / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D009669:Nose Neoplasms / Q000556:secondary*; D009418:S100 Proteins / Q000032:analysis; D012447:Sacrum / Q000473:pathology*; D012878:Skin Neoplasms / Q000556:secondary*; D013125:Spinal Neoplasms / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000175:diagnosis; D014746:Vimentin / Q000032:analysis
D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins