title: Ototoxicity of ear drops: a clinical perspective.
abstract: Although experimental data confirm the presence of ototoxicity due to topical ear drops, the clinical relevance still remains debatable. Only few case reports document sensorineural hearing loss (SNHL) attributable to ototopical preparations in patients with chronic otitis media. A careful review of 134 patients charts evaluated between 1953 and 1995 for possible antibiotic related ototoxicity revealed two patients with bilateral profound SNHL attributable to excessive administration of framycetin- and polymyxin-containing ear drops in the presence of tympanic membrane perforation. Although ototopical preparations are widely used, they rarely induce SNHL. The authors emphasize patient education, application of topical ear drops using soaked gauze strips, and documentation of the patients hearing status at the beginning of the treatment regimen.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Zürich, Switzerland.
authors.forename: T E
authors.initials: TE
authors.lastname: Linder
authors.forename: S
authors.initials: S
authors.lastname: Zwicky
authors.forename: P
authors.initials: P
authors.lastname: Brändle
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002908:Chronic Disease; D004338:Drug Combinations; D005601:Framycetin / Q000008:administration & dosage / Q000009:adverse effects*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006320:Hearing Tests; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009355:Neomycin / Q000008:administration & dosage / Q000009:adverse effects*; D010033:Otitis Media / Q000188:drug therapy*; D011112:Polymyxin B / Q000008:administration & dosage / Q000009:adverse effects*; D012996:Solutions
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D012996:Solutions; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D005601:Framycetin; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone