[Immediate suppression of endogenous cortisol secretion after single oral administration of 6-alpha-methylprednisolone].
Plasma samples from 5 asthma patients were taken in 4-h intervals before and 1, 2, 4 and 6 h after the oral application of 100 mg methylprednisolone. Reversed-phase HPLC allowed simultaneous measurement of both endogenous hydrocortisone and exogeneous methylprednisolone. Suppression of endogeneous hydrocortisone secretion occurs immediately after administration of a single oral dose of an exogeneous glucocorticoid and cannot be avoided by morning application.
Hampe
S
S
Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, München, Deutschland.
Haen
E
E
Emslander
H P
HP
D000284:Administration, Oral; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D004334:Drug Administration Schedule; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012636:Secretory Rate / Q000187:drug effects / Q000502:physiology
D006854:Hydrocortisone; D008775:Methylprednisolone