Suppression of evoked IPSPs by arachidonic acid and prostaglandin F2 alpha.
Arachidonic acid (AA) and certain prostaglandins appear to antagonize GABAA receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prostaglandin F2 alpha diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.
Owens
J
J
University of Washington, Seattle 98195, USA.
Schwartzkroin
P A
PA
D000704:Analysis of Variance; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology*; D003864:Depression, Chemical; D015237:Dinoprost / Q000494:pharmacology*; D004553:Electric Conductivity; D017097:Electric Impedance; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D017966:Pyramidal Cells / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D016718:Arachidonic Acid; D015237:Dinoprost