title: Mapping of a susceptibility locus for Crohn's disease on chromosome 16.
abstract: Crohn's disease (CD) and ulcerative colitis are the major forms of chronic inflammatory bowel diseases in the western world, and occur in young adults with an estimated prevalence of more than one per thousand inhabitants. The causes of inflammatory bowel diseases remain unknown, but genetic epidemiology studies suggest that inherited factors may contribute in part to variation in individual susceptibility to Crohn's disease. A genome-wide search performed on two consecutive and independent panels of families with multiple affected members, using a non-parametric two-point sibling-pair linkage method, identified a putative CD-susceptibility locus on chromosome 16 (P less than 0.01 for each panel). The localization was centered around loci D16S409 and D16S419 by using multipoint sibpair analysis (P less than 1.5x10(-5)). This region of the genome contains candidate genes which may be relevant to the pathogenic mechanism of inflammatory bowel diseases.
authors.affiliation: Laboratoire de Génétique des Tumeurs, INSERM U 434, Institut Curie, Paris France.
authors.forename: J P
authors.initials: JP
authors.lastname: Hugot
authors.forename: P
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: C
authors.initials: C
authors.lastname: Gower-Rousseau
authors.forename: J M
authors.initials: JM
authors.lastname: Olson
authors.forename: J C
authors.initials: JC
authors.lastname: Lee
authors.forename: L
authors.initials: L
authors.lastname: Beaugerie
authors.forename: I
authors.initials: I
authors.lastname: Naom
authors.forename: J L
authors.initials: JL
authors.lastname: Dupas
authors.forename: A
authors.initials: A
authors.lastname: Van Gossum
authors.forename: M
authors.initials: M
authors.lastname: Orholm
authors.forename: C
authors.initials: C
authors.lastname: Bonaiti-Pellie
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: C G
authors.initials: CG
authors.lastname: Mathew
authors.forename: J E
authors.initials: JE
authors.lastname: Lennard-Jones
authors.forename: A
authors.initials: A
authors.lastname: Cortot
authors.forename: J F
authors.initials: JF
authors.lastname: Colombel
authors.forename: G
authors.initials: G
authors.lastname: Thomas
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D003424:Crohn Disease / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans
chemical_list: D005819:Genetic Markers