title: Effect of essential amino acid supplementation in acute renal failure.
abstract: The effect of intravenous (i.v.) essential amino acids (EAA) in the treatment of acute renal failure was evaluated in 50 patients. Thirty patients (Group A) received daily 13.4 g of i.v. EAA solution [Nephramine (Don Baxter, McGraw) 250 ml/d]+dopamine i.v. 2 micrograms/kg/min + 20% hypertonic glucose solution 500 ml/d as compared with twenty patients (Group B) who received dopamine i.v. 2 micrograms/kg/min + 20% hypertonic glucose solution 500 ml/d. In Group A patients showed lower daily increase in blood urea nitrogen (BUN) (p < 0.05), higher serum total protein and albumin levels on the 15th day of the posttherapy period (p < 0.001), lower complication rate (p < 0.005), lower mortality rate (p < 0.005) and a reverse relation between serum total protein concentration, duration of oliguria and age (p < 0.01, r2 = 0.26; p < 0.001, r2 = 0.32). These data suggest that treatment of such patients with i.v. EAA solutions significantly improves survival.
authors.affiliation: Department of Internal Medicine, School of Medicine, Black Sea Technical University, Trabzon, Turkey.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Mocan
authors.forename: H
authors.initials: H
authors.lastname: Mocan
authors.forename: M N
authors.initials: MN
authors.lastname: Gacar
authors.forename: G K
authors.initials: GK
authors.lastname: Ozgür
authors.forename: M H
authors.initials: MH
authors.lastname: Uluutku
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D000601:Amino Acids, Essential / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D004298:Dopamine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009846:Oliguria / Q000097:blood
chemical_list: D000601:Amino Acids, Essential; D004298:Dopamine