Oxidized lipoproteins.
The understanding of the role of lipoprotein oxidation is still incomplete. Much is still to be learned about the mechanism of action of oxidized lipoproteins on different types of cell, as well as the origin of the oxidation process, and how it links to the situation in vivo. The benefits or otherwise of anti-oxidant therapy or dietary advice will be solved only by long-term studies, some of which have been begun or are planned. It is useful to recall that information about the effects of cholesterol-lowering therapy with statins are only now becoming available after several years of use. Convincing data about the efficacy of anti-oxidants are some way off, even though, on balance, the results so far appear encouraging.
Bruckdorfer
K R
KR
Department of Biochemistry and Molecular Medicine, Royal Free Hospital School of Medicine, London, UK.
D001161:Arteriosclerosis / Q000209:etiology; D001775:Blood Circulation; D001777:Blood Coagulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D010084:Oxidation-Reduction
D008074:Lipoproteins