title: Allele frequency distribution for the variable number of tandem repeat locus D10S28 in Tamil Nadu (south India) population.
abstract: Allele frequencies were determined in unrelated individuals of Tamil speaking population from the Madras City (Tamil Nadu, South India) area for the polymorphic DNA locus D10S28 using the probe TBQ7. Membranes hybridized with the probe YNH24 were subjected to deprobing and were subsequently hybridized with random priming - labeled, purified inserts of TBQ7. The sizes of the fragments were grouped to 100 bp as well as to arbitrary fixed bins (Federal Bureau of Investigation / Royal Canadian Mounted Police). There were 14 bins in the latter with the most common bin being 11 (1789-1924 bp) with a frequency of 9.8%. We observed a heterozygosity of 92% comparable to Caucasian populations. The data presented here can be used as the basis for utilizing this variable number of tandem repeats (TNTR) DNA marker for paternity determinations and forensic investigations.
authors.affiliation: Forensic Sciences Department, Mylapore, Madras, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Pandian
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Krishnan
authors.forename: K
authors.initials: K
authors.lastname: Dharmalingam
authors.forename: C
authors.initials: C
authors.lastname: Damodaran
mesh_terms: D000483:Alleles; D016009:Chi-Square Distribution; D002874:Chromosome Mapping; D016208:Databases, Factual; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D006801:Humans; D007194:India; D008297:Male; D018598:Minisatellite Repeats