Happenstance, circumstance or enemy action: cyclin D1 in breast, eye and brain.
Two recent reports of mice homozygously deleted for cyclin D1 provide unequivocal evidence that the critical G1 cyclin, cyclin D1, is by itself rate-limiting for growth in some mammalian tissues. Cyclin D1 knockout mice are small and exhibit behavioral abnormalities. Specific hypoplasias of retinal and mammary tissues suggest an unusual dependence on cyclin D1 function for tissue growth in those organs. The odd coincidences that cyclin D1 functions as the retinoblastoma gene kinase, together with associations between increased cyclin D1 expression and breast cancer, suggest, but do not prove, a special function of cyclin D1 in those tissues.
Schmidt
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EV
MGH Cancer Center, Charlestown 02129, USA.
D000015:Abnormalities, Multiple / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000378:metabolism; D002455:Cell Division; D019938:Cyclin D1; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D004967:Estrogens / Q000502:physiology; D005124:Eye Abnormalities / Q000235:genetics* / Q000378:metabolism; D005260:Female; D016193:G1 Phase / Q000502:physiology*; D008321:Mammary Glands, Animal / Q000002:abnormalities* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000502:physiology; D015513:Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D011372:Progestins / Q000502:physiology; D011499:Protein Processing, Post-Translational; D016160:Retinoblastoma Protein / Q000378:metabolism
D016213:Cyclins; D004967:Estrogens; D009419:Nerve Tissue Proteins; D015513:Oncogene Proteins; D011372:Progestins; D016160:Retinoblastoma Protein; D019938:Cyclin D1; D018844:Cyclin-Dependent Kinases