Synthesis and biological evaluation of 7-azaanalogues of ipsapirone.
The synthesis and preliminary pharmacological evaluation of 4,6-dimethyl-7-azaipsapirone (5c) and related compounds bearing the r-(phenyl, pyridyl, pyrimidinyl)-1-piperazinyl moiety linked through a butyl or ethoxyethyl chain with the isothiazolo[5,4-b]pyridine system, are described.
Malinka
W
W
Department of Chemistry of Drugs, Wroclaw University of Medicine, Poland.
Sielklucka-Dziuba
M
M
Rajtar
G
G
Marowska
D
D
Kleinrok
Z
Z
D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology*
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; C043077:ipsapirone; D000661:Amphetamine