title: Central retinal vein and branch artery occlusion associated with inherited plasminogen deficiency and high lipoprotein(a) levels: a case report.
abstract: We describe a case of central retinal vein and branch artery occlusion associated with inherited type I plasminogen deficiency (68%) and permanent elevation of Lp(a) (460 mg/l, S2 phenotype) in a 45 year old white woman with no associated local or systemic risk factors. Pedigree analysis revealed inheritance of plasminogen deficiency from the deceased father and of high Lp(a) levels from the mother. Both the patient's sons had plasminogen deficiency, but they had normal Lp(a) levels. In a series of 40 consecutive patients with central retinal vein occlusion we previously reported the observation of high Lp(a) levels--consistently associated with the S2 phenotype--in 30% of the patients as compared to a 10% incidence in controls. This case emphasizes the importance of screening patients with occlusion of the retinal vessels and no associated risk factors for coagulation abnormalities predisposing to thrombosis.
authors.affiliation: Department of Ophthalmology and Viasual Sciences, University of Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tavola
authors.forename: S V
authors.initials: SV
authors.lastname: D'Angelo
authors.forename: F
authors.initials: F
authors.lastname: Bandello
authors.forename: R
authors.initials: R
authors.lastname: Brancato
authors.forename: M
authors.initials: M
authors.lastname: Parlavecchia
authors.forename: O
authors.initials: O
authors.lastname: Safa
authors.forename: A
authors.initials: A
authors.lastname: D'Angelo
mesh_terms: D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008875:Middle Aged; D010958:Plasminogen / Q000172:deficiency*; D015356:Retinal Artery Occlusion / Q000097:blood / Q000150:complications* / Q000235:genetics; D012170:Retinal Vein Occlusion / Q000097:blood / Q000150:complications* / Q000235:genetics
chemical_list: D017270:Lipoprotein(a); D010958:Plasminogen