title: The neurochemical and metabolic cascade following brain injury: moving from animal models to man.
abstract: Experimental traumatic brain injury produces a series of cellular events contributing to a neurochemical and neurometabolic cascade. This cascade is defined by the release of neurotransmitters resulting in a massive ionic flux, which, consequently, produces an increase in glycolysis. This increase in glycolysis is followed by a metabolic diaschisis, which is related to the degree and extent of behavioral deficits. Clinical efforts have now determined that a similar cascade occurs in human head injury, validating the animal model as well as providing new assessment strategies for the management and treatment of brain injury.
authors.affiliation: Department of Surgery, UCLA School of Medicine 90024, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Hovda
authors.forename: S M
authors.initials: SM
authors.lastname: Lee
authors.forename: M L
authors.initials: ML
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Von Stuck
authors.forename: M
authors.initials: M
authors.lastname: Bergsneider
authors.forename: D
authors.initials: D
authors.lastname: Kelly
authors.forename: E
authors.initials: E
authors.lastname: Shalmon
authors.forename: N
authors.initials: N
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Caron
authors.forename: J
authors.initials: J
authors.lastname: Mazziotta
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D004195:Disease Models, Animal; D006019:Glycolysis; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D013045:Species Specificity
chemical_list: D018377:Neurotransmitter Agents