title: [Gingival metastasis of large-cell lung cancer that produced G-CSF].
abstract: A 68-year-old man was referred to our hospital for further examination of a gingival mass. Chest radiographs and magnetic resonance imaging disclosed a bulky mass originating in the upper portion of the left lung, in contact with a chronic empyema lesion that first occurred after resection for pulmonary tuberculosis. Examination of a specimen obtained by percutaneous needle biopsy of the mass led to the diagnosis of large-cell carcinoma. Laboratory findings on admission showed marked leukocytosis (48,100/microliter) without evidence of severe a bacterial infection. The level of G-CSF in serum was abnormally high (246 pg/ml, normal value: < 30 pg/ml). Chemotherapy with vindesine, ifosfamide, and cisplatin resulted in shrinkage of the gingival mass, and a decrease in the G-CSF level to 66 pg/ml. Immunohistochemical staining with an anti-G-CSF monoclonal antibody to the primary lung tumor and the gingival mass obtained at autopsy was positive for cytoplasmic G-CSF.
authors.affiliation: Department of Medicine, Okayama University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miyatake
authors.forename: H
authors.initials: H
authors.lastname: Ueoka
authors.forename: M
authors.initials: M
authors.lastname: Tabata
authors.forename: T
authors.initials: T
authors.lastname: Shibayama
authors.forename: K
authors.initials: K
authors.lastname: Gemba
authors.forename: J
authors.initials: J
authors.lastname: Hiyama
authors.forename: T
authors.initials: T
authors.lastname: Ohnoshi
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Nishii
authors.forename: Y
authors.initials: Y
authors.lastname: Moritani
mesh_terms: D000368:Aged; D018287:Carcinoma, Large Cell / Q000378:metabolism* / Q000556:secondary*; D005887:Gingival Neoplasms / Q000378:metabolism* / Q000556:secondary*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male
chemical_list: D016179:Granulocyte Colony-Stimulating Factor