Sterols from the Caribbean sponge Neofibularia nolitangere. Isolation of two novel polyhydroxysteroids.
The sterol composition of the Caribbean sponge Neofibularia nolitangere has been investigated. In addition to usual sterols this sponge elaborates comparable amounts of 24-methylene-4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (1), which is very unusual among sponge sterols, and lesser quantities of two new polyoxygenated sterols, (24S)-24-ethyl-5 alpha-cholest-8-ene-5,6 beta,7 alpha-triol (2) and (24S)-24-ethyl-5 alpha-cholest-8(14)-ene-5,6 beta,7 alpha-triol (3).
Costantino
V
V
Dipartimento di Chimica delle Sostanze Naturali, Naples, Italy.
Fattorusso
E
E
Mangoni
A
A
Pansini
M
M
D000818:Animals; D002782:Cholestenes / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid / Q000379:methods; D006914:Hydroxysteroids / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification
C098162:24-ethylcholest-8(14)-ene-5,6,7-triol; C098163:24-ethylcholest-8-ene-5,6,7-triol; C098161:24-methylene-4-methylcholest-8-en-3-ol; D002782:Cholestenes; D006914:Hydroxysteroids; D013261:Sterols