[Drug kinetics in soft contact lenses. I. In vitro studies].
The in vitro kinetics (specifically, absorption and desorption) of drugs belonging to various pharmacological groups (atropine sulfate, gentamicin sulfate, dexamethasone, lecozyme, and poludan) in soft contact lenses (low-hydrophilic with 40% aqueous content and highly hydrophilic with 74% aqueous content. 0.2 and 0.7 mm thick) was studied by radiometry, as were the effects of chemical structure of a drug, hydrophilic properties and thickness of soft contact lenses, and temperature of solution on these processes.
Rybakova
E G
EG
Avetisov
S E
SE
Badun
G A
GA
Krasnianskiĭ
A V
AV
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001285:Atropine / Q000008:administration & dosage / Q000493:pharmacokinetics; D003263:Contact Lenses, Hydrophilic; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000008:administration & dosage / Q000493:pharmacokinetics; D009184:Mydriatics / Q000008:administration & dosage / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D011131:Polyribonucleotides; D011874:Radiometry
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005839:Gentamicins; D007369:Interferon Inducers; D009184:Mydriatics; D004364:Pharmaceutical Preparations; D011131:Polyribonucleotides; C044366:poludan; D001285:Atropine; D003907:Dexamethasone