title: Influence of anesthetics on the peripheral blood microfilaremia of Brugia malayi in the Mongolian jird, Meriones unguiculatus.
abstract: The effects of anesthetics on the peripheral blood microfilaremia of Brugia malayi in Meriones unguiculatus were investigated. Microfilaremias were assessed by orbital puncture prior to and following the use, either individually or in tandem, of ether, Rompun, Ketaset, and sodium pentobarbital. Results indicate that the peripheral microfilaremia varied dramatically, depending on the anesthetic administered. Although microfilaremias were not affected by an initial ether exposure, counts of microfilariae increased significantly when jirds received Rompun and Ketaset, or Ketaset alone. Administration of sodium pentobarbital did not increase the number of microfilariae observed in the peripheral blood. The mode of action differs between these drugs and is likely responsible for the different effects observed. Consequently, studies involving vector-parasite interactions should take precautions to prevent parasite-induced vector mortality due to the ingestion of large numbers of microfilariae induced in the peripheral bloodstream by certain anesthetics.
authors.affiliation: Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA.
authors.forename: B T
authors.initials: BT
authors.lastname: Beerntsen
authors.forename: C A
authors.initials: CA
authors.lastname: Lowenberger
authors.forename: J A
authors.initials: JA
authors.lastname: Klinkhammer
authors.forename: L A
authors.initials: LA
authors.lastname: Christensen
authors.forename: B M
authors.initials: BM
authors.lastname: Christensen
mesh_terms: D000704:Analysis of Variance; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D017178:Brugia malayi / Q000187:drug effects*; D004195:Disease Models, Animal; D004605:Elephantiasis, Filarial / Q000469:parasitology*; D004986:Ether / Q000494:pharmacology; D005260:Female; D005849:Gerbillinae; D007649:Ketamine / Q000494:pharmacology; D008842:Microfilariae / Q000187:drug effects; D018512:Parasitemia / Q000469:parasitology*; D010424:Pentobarbital / Q000494:pharmacology; D014991:Xylazine / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D004986:Ether; D014991:Xylazine; D007649:Ketamine; D010424:Pentobarbital