Cytogenetic support for primary prostatic cancer in a patient presenting with a soft tissue mass in the leg.
A 65-year old man presented with a soft tissue mass in the leg, clinically suspect of a sarcoma. Histologic examination suggested a metastatic adenocarcinoma of the prostate, which could not be confirmed by immunohistologic studies. However, cytogenetic analysis strongly supported this diagnosis. A primary prostatic carcinoma was indeed found and the patient died of widely disseminated disease. These findings illustrate the significance of chromosomal analysis in the search for a primary tumor in patients with an unknown primary.
Molenaar
W M
WM
Department of Pathology, University Hospital of Groningen, The Netherlands.
Stoepker
M E
ME
de Ruiter
A J
AJ
Hoekstra
H J
HJ
van den Berg
E
E
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D007866:Leg; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000556:secondary