[Neoadjuvant chemotherapy with continuous intra-arterial infusion (cisplatin, 5-fluorouracil) in the treatment of stage III cervical cancer].
Continuous arterial infusion therapy with a reservoir for neoadjuvant chemotherapy was used in 12 cases of cervical carcinoma, clinically progressive Stage III, to examine its usefulness. Drugs used were cisplatin, 10 mg/day (one shot) and 5-fluorouracil, 250 mg/day (continuous), which were infused from bilateral subhypogastric reservoirs to bilateral internal iliac arteries for 10 days (one course) at a rate of 2 times per 3 weeks. As a result, diminution of main lesion was observed in all cases, and radical hysterectomy could be performed on all but one of 11 patients, who refused the surgery. Histological examination of resected uteri revealed Grade III (3 cases, Grade II (6 cases), Grade I b (1 case) and Grade I a (1 case). The present therapy enabled us to obtain not only AUC of filterable platinum, comparable to 2 hour-drip infusion of cisplatin 100 mg/day, but also therapeutic effects on lymphnodal metastasis. In spite of this excellent effectiveness, slight side effects such as hemotoxicity, Grades 1 and 2, and digestive disorder, were noted. From the above, the present therapy, despite the slight side effects, can be regarded as an effective therapeutic approach which enables us not only to stage down progressive Stage-III cervical carcinoma and to indicate radical hysterectomy, but also expect an improved prognosis.
Narimatsu
A
A
Dept. of Obstetrics and Gynecology, Nagato General Hospital.
Okada
O
O
Ito
T
T
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D002945:Cisplatin; D005472:Fluorouracil