title: 2-Arylmethyl-1,4-benzoquinones. I. Novel inhibitors of platelet aggregation: synthesis and pharmacological evaluation.
abstract: A new series of 2-arylmethyl-1,4-benzoquinones (2) was synthesized for evaluation of their pharmacological activities. These compounds showed significant inhibition of platelet aggregation induced by arachidonic acid (AA) and some of them possessed a protective effect against endothelial cell injury caused by hydrogen peroxide.
authors.affiliation: Suntory Institute for Biomedical Research, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tatsuoka
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: K
authors.initials: K
authors.lastname: Aisaka
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: R
authors.initials: R
authors.lastname: Ogino
authors.forename: M
authors.initials: M
authors.lastname: Kuroki
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: F
authors.initials: F
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Miyano
authors.forename: K
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D016227:Benzoquinones; D010975:Platelet Aggregation Inhibitors