Cyclosporine A: clinical experience and therapeutic drug monitoring.
This article updates current studies on the concentration-effect relationship for cyclosporine A using specific analytical methodology in whole blood. Most of the existing documentation concerns renal transplantation. Trough level monitoring is recommended as the standard monitoring technique. However, there is a need to compare trough level monitoring with monitoring of the area-under-the-concentration-versus-time curve in prospective controlled trials. Further, there is a continuous need to update the concentration-effect relationship when introducing new immunosuppressive drug regimens.
Lindholm
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Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden.
D016572:Cyclosporine / Q000097:blood* / Q000627:therapeutic use*; D016903:Drug Monitoring; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D016572:Cyclosporine