hSRY: molecular gender bender.
The recently published solution structure of the DNA-binding domain of hSRY in complex with a DNA octamer offers insight into the sex reversal effects of mutations in hSRY and the interaction of all HMG boxes with DNA.
Bramham
J
J
Department of Biochemistry, University of Dundee, UK.
Norman
D G
DG
D001665:Binding Sites; D018360:Crystallography, X-Ray; D004268:DNA-Binding Proteins / Q000737:chemistry*; D006609:High Mobility Group Proteins / Q000737:chemistry*; D006801:Humans; D008297:Male; D008958:Models, Molecular; D009687:Nuclear Proteins; D011287:Prejudice; D017433:Protein Structure, Secondary; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors / Q000737:chemistry*
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors