title: [The use of the screening of maternal serum factors for the prenatal diagnosis of fetal developmental defects and chromosomal diseases].
abstract: The association of the levels of alpha-fetoprotein and chorionic gonadotropin with congenital developmental defects and chromosomal abnormalities of fetus was studied. The correlation of elevated level of alpha-fetoprotein with defects of neuraxis, kidney and abdominal wall of fetus was shown. These data are used for screening of women with a high risk for Down's syndrome and other chromosomal abnormalities.
authors.forename: S B
authors.initials: SB
authors.lastname: Arbuzova
authors.forename: M I
authors.initials: MI
authors.lastname: Nikolenko
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000517:prevention & control*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000517:prevention & control*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods* / Q000706:statistics & numerical data; D014455:Ukraine; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins