Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists.
Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this "priming" effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.
Self
D W
DW
Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, 06508, USA.
Barnhart
W J
WJ
Lehman
D A
DA
Nestler
E J
EJ
D000818:Animals; D016739:Behavior, Addictive / Q000209:etiology*; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D003042:Cocaine / Q000008:administration & dosage; D018491:Dopamine Agonists / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D019257:Quinpirole; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000819:agonists / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000502:physiology*; D012008:Recurrence; D012054:Reinforcement, Psychology; D019966:Substance-Related Disorders / Q000209:etiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D001552:Benzazepines; D018491:Dopamine Agonists; D004873:Ergolines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013764:Tetrahydronaphthalenes; D019257:Quinpirole; D002110:Caffeine; C067113:SK&F 81297; C071262:SK&F 82958; D003042:Cocaine; C031349:7-hydroxy-2-N,N-dipropylaminotetralin