title: Quantification of liver blood volume: comparison of ultra short TI inversion recovery echo planar imaging (ULSTIR-EPI), with dynamic 3D-gradient recalled echo imaging.
abstract: An ultra-short TI inversion recovery echo-planar imaging (ULSTIR-EPI) sequence was designed to reduce the influence of water exchange on fractional tissue blood volume (BV) estimation by measurement of T1-changes induced by a gadolinium-based macromolecular contrast medium (MMCM). Fractional liver BV in rats, estimated by ULSTIR-EPI was compared for accuracy to a fast T1-weighted three-dimensional gradient-echo (3D-SPGR, 3D-spoiled gradient recalled acquisition in a steady state) sequence using an in vitro inductively coupled plasma atomic emission spectroscopy (ICP-AES) assay for BV as a standard. Liver images for fractional BV estimation were acquired in eight rats using both ULSTIR-EPI and 3D-SPGR before and after (within 3 to 12 min) intravenous bolus administration of albumin-Gd-DTPA30 (0.05 mmol Gd/kg). Whereas both MR techniques may be useful for fractional tissue BV estimation, ULSTIR-EPI offers certain advantages including greater accuracy, direct T1 maps, and minimization of transendothelial proton exchange effects. 3D-SPGR imaging offers better spatial resolution, current availability on standard clinical MR systems, and acceptable accuracy.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Schwickert
authors.forename: T P
authors.initials: TP
authors.lastname: Roberts
authors.forename: D M
authors.initials: DM
authors.lastname: Shames
authors.forename: C F
authors.initials: CF
authors.lastname: van Dijke
authors.forename: A
authors.initials: A
authors.lastname: Disston
authors.forename: A
authors.initials: A
authors.lastname: Mühler
authors.forename: J S
authors.initials: JS
authors.lastname: Mann
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
mesh_terms: D000418:Albumins; D000818:Animals; D001810:Blood Volume; D001811:Blood Volume Determination; D003287:Contrast Media; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000033:anatomy & histology / Q000098:blood supply*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000418:Albumins; D003287:Contrast Media; D009942:Organometallic Compounds; C058946:albumin-(gadolinium-DTPA); D004369:Pentetic Acid; D019786:Gadolinium DTPA