title: Histological and mechanical comparison of hydroxyapatite-coated cobalt-chrome and titanium implants in the rabbit femur.
abstract: The purpose of this study was to compare hydroxyapatite (HA)-coated titanium (Ti) and HA-coated cobalt-chrome (CoCr) implants in the distal femur of the rabbit by evaluating bone apposition and interfacial shear strength. Bilateral cylindrical implants with a plasma sprayed 50-microns thick HA coating were press-fit into the metaphyseal cancellous bone of the lateral femoral condyles in a transverse fashion, and the animals were sacrificed at 2, 4, and 8 weeks postimplantation. Mechanical strength of the interface between HA and bone was measured using the pushout method. For histologic analysis, the fractional linear extent of bone apposition was quantitated. No differences were found in the interfacial shear strength between the Ti and CoCr at any time period. The amount of bone apposition increased significantly at each time interval for both substrate metals, but there were no significant differences between the two substrates at any of the time periods studied. The HA-coated CoCr implants performed in a similar manner to the HA-coated Ti implants, both mechanically and histologically, suggesting that HA-coated CoCr implants deserve further study as a viable alternative to Ti for the biological fixation of total joint components in orthopaedic surgery.
authors.affiliation: Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Friedman
authors.forename: T W
authors.initials: TW
authors.lastname: Bauer
authors.forename: K
authors.initials: K
authors.lastname: Garg
authors.forename: M
authors.initials: M
authors.lastname: Jiang
authors.forename: Y H
authors.initials: YH
authors.lastname: An
authors.forename: R A
authors.initials: RA
authors.lastname: Draughn
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D002858:Chromium Alloys; D017886:Durapatite; D005269:Femur / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007720:Knee Prosthesis; D008297:Male; D008422:Materials Testing; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D013997:Time Factors; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D002858:Chromium Alloys; D017886:Durapatite; D014025:Titanium