title: Resuscitation from severe hemorrhage.
abstract: The potential to be successfully resuscitation from severe traumatic hemorrhagic shock is not only limited by the "golden 1 hr", but also by the "brass (or platinum) 10 mins" for combat casualties and civilian trauma victims with traumatic exsanguination. One research challenge is to determine how best to prevent cardiac arrest during severe hemorrhage, before control of bleeding is possible. Another research challenge is to determine the critical limits of, and optimal treatments for, protracted hemorrhagic hypotension, in order to prevent "delayed" multiple organ failure after hemostasis and all-out resuscitation. Animal research is shifting from the use of unrealistic, pressure-controlled, hemorrhagic shock models and partially realistic, volume-controlled hemorrhagic shock models to more realistic, uncontrolled hemorrhagic shock outcome models. Animal outcome models of combined trauma and shock are needed; a challenge is to find a humane and clinically realistic long-term method for analgesia that does not interfere with cardiovascular responses. Clinical potentials in need of research are shifting from normotensive to hypotensive (limited) fluid resuscitation with plasma substitutes. Topics include optimal temperature, fluid composition, analgesia, and pharmacotherapy. Hypotensive fluid resuscitation in uncontrolled hemorrhagic shock with the addition of moderate resuscitative (28 degrees to 32 degrees C) hypothermia looks promising in the laboratory. Regarding the composition of the resuscitation fluid, despite encouraging results with new preparations of stroma-free hemoglobin and hypertonic salt solutions with colloid, searches for the optimal combination of oxygen-carrying blood substitute, colloid, and electrolyte solution for limited fluid resuscitation with the smallest volume should continue. For titrating treatment of shock, blood lactate concentrations are of questionable value although metabolic acidemia seems helpful for prognostication. Development of devices for early noninvasive monitoring of multiple parameters in the field is indicated. Molecular research applies more to protracted hypovolemic shock followed by the systemic inflammatory response syndrome or septic shock, which were not the major topics of this discussion.
authors.affiliation: Department of Emergency Medicine, King/Drew Medical Center, Los Angeles, CA 90059, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Shoemaker
authors.forename: A B
authors.initials: AB
authors.lastname: Peitzman
authors.forename: R
authors.initials: R
authors.lastname: Bellamy
authors.forename: R
authors.initials: R
authors.lastname: Bellomo
authors.forename: S P
authors.initials: SP
authors.lastname: Bruttig
authors.forename: A
authors.initials: A
authors.lastname: Capone
authors.forename: M
authors.initials: M
authors.lastname: Dubick
authors.forename: G C
authors.initials: GC
authors.lastname: Kramer
authors.forename: J E
authors.initials: JE
authors.lastname: McKenzie
authors.forename: P E
authors.initials: PE
authors.lastname: Pepe
authors.forename: P
authors.initials: P
authors.lastname: Safar
authors.forename: R
authors.initials: R
authors.lastname: Schlichtig
authors.forename: J W
authors.initials: JW
authors.lastname: Severinghaus
authors.forename: S A
authors.initials: SA
authors.lastname: Tisherman
authors.forename: L
authors.initials: L
authors.lastname: Wiklund
mesh_terms: D000818:Animals; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D008991:Monitoring, Physiologic; D009102:Multiple Organ Failure / Q000209:etiology; D009104:Multiple Trauma / Q000150:complications*; D012106:Research; D012771:Shock, Hemorrhagic / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome