title: [Laboratory indicators in drug addicts and tertiary prevention of narcotic dependence].
abstract: BACKGROUND
  The authors report on some laboratory indicators in opiate abusers dependent for prolonged periods on opiates. The objective of the study is a proposal for an examination pattern in adepts during oral substitution therapy and emphasis on the necessity of systematic follow up of the health status.
  
  
  RESULTS
  In 27 opiate abusers with a varying period of dependence on opiates the hematology laboratory tests was assessed, plasma levels of some minerals, renal and hepatic functions, some enzymes and metabolic indicators and vitamin D metabolites. For statistical evaluation Student's t-test was used and simultaneous testing.
  
  
  CONCLUSIONS
  Long-term opiate abuse damages in 30 and 35% resp. liver functions. Therefore vitamin D deficiency develops. The authors recommend to follow up the health status of opiate abusers during oral substitution treatment (tertiary prevention).
authors.affiliation: III. Interní klinika 1. LF UK a VFN, Praha.
authors.forename: H
authors.initials: H
authors.lastname: Wilczek
authors.forename: J
authors.initials: J
authors.lastname: Presl
authors.forename: I
authors.initials: I
authors.lastname: Douda
mesh_terms: D000328:Adult; D005036:Ethylmorphine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009294:Narcotics / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000378:metabolism* / Q000534:rehabilitation*
chemical_list: D009294:Narcotics; D005036:Ethylmorphine