title: Bone allografts in periodontal therapy.
abstract: Bone allografts as used in dentistry have a 20-year history of safety and efficacy. Case reports and controlled clinical trials have shown the potential of both mineralized and decalcified cortical freeze-dried bone allograft to reconstruct the bone defects caused by periodontitis. Histomorphometric analysis of human biopsies following grafts of decalcified freeze-dried bone allograft have shown the ability of decalcified freeze-dried bone allograft to promote regeneration of new bone, cementum, and periodontal ligament on a tooth root surface previously exposed to bacterial plaque. The addition of mineralized freeze-dried bone allograft and decalcified freeze-dried bone allograft to the guided tissue and guided bone regeneration procedures have significantly enhanced results, especially in large osseous lesions.
authors.affiliation: Department of Periodontics, The University of Texas Health Science Center, San Antonio, TX 78284-7894, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Mellonig
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D016025:Bone Transplantation; D003648:Decalcification Technique; D005612:Freeze Drying; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D010518:Periodontitis / Q000601:surgery*; D012449:Safety; D014184:Transplantation, Homologous
chemical_list: D018786:Bone Substitutes