[The antioxidant system and lipid peroxidation in chickens during postnatal ontogenesis].
Age peculiarities of functioning of antioxidizing system of chickens in postnatal ontogenesis were exposed for the first time. High superoxide dismutase activity in the organs and tissues of the 24 hours' chickens is to be considered as a compensatory defense during the transition from hypoxia of the end of embryo development to the relative hyperoxia after hatching. In the early postnatal ontogenesis superoxide dismutase activity declines, while the activity of peroxidase, catalase and enzymes of glutathione cycle increases. The mentioned changes reach maximum at the age of 20-30 days. The insufficient defense of chicken organism from the active forms of oxygen leads to the shift of oxidizing processes towards free-radical ones, to the decrease of concentration of lipids, phospholipids, retinol, inhibition of protein biosynthesis. Intensification of the processes of lipids peroxidation occurs before the decrease of alpha-tocopherol level. Functional dependence of chickens growth intensity on biochemical indices of their antioxidant system is of complex nonlinear character and is described by the forth degree polynomials.
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D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D002374:Catalase / Q000378:metabolism; D002645:Chickens; D004912:Erythrocytes / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D009195:Peroxidase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002374:Catalase; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase