[Post-radiation disturbances in the cyclic nucleotide system in rat spleen and thymus lymphocytes].
The changes in cAMP and cGMP content in rat spleen and thymus lymphocytes after irradiation in doses of 0.5 and 1 Gy, are determined, indicating to significant disturbances in the system of cyclic nucleotides. Radiation affected the functioning of enzymes both of synthesis and hydrolysis of cAMP and cGMP in spleen lymphocytes. The activity of adenylate cyclase and guanylate cyclase did not change in thymocytes after the exposure, while the activity of phosphodiesterase of cyclic nucleotides slightly increased.
Ostapchenko
L I
LI
Parkhomets
T I
TI
Nalevina
O E
OE
Kucherenko
N E
NE
D000262:Adenylyl Cyclases / Q000528:radiation effects; D000818:Animals; D000242:Cyclic AMP / Q000528:radiation effects*; D006152:Cyclic GMP / Q000528:radiation effects*; D005260:Female; D006162:Guanylate Cyclase / Q000528:radiation effects; D006868:Hydrolysis; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*
D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP