title: Different responses of insulin, C-peptide, and testosterone to an oral glucose tolerance test in two groups of women with polycystic ovarian syndrome.
abstract: BACKGROUND
  To further investigate the relationship between inappropriate gonadotropin, hyperinsulinemia and androgen excess.
  
  
  METHODS
  We divided women with polycystic ovarian syndrome (PCOS) into two groups on the basis of LH/FSH (LH/FSH > or = 3, Group 1, n=30; LH/FSH<3, Group 2, n=25) and measured the responses of insulin, C-peptide (C-P), C-P/insulin (C-I) and testosterone concentrations to an oral glucose tolerance test (OGTT) in these patients and 15 control subjects.
  
  
  RESULTS
  Significant positive correlations were found between basal LH and T (r=O.58, p<0.05) in Group 1, and between fasting serum insulin and T (r=0.48, p<0.05) in Group 2. Although these patients had higher, delayed insulin and C-P responses to OGTT than the control group, much greater insulin and C-P levels and lower C/I values were found in Group 2. T concentrations decreased mildly during OGTT in Group 1 and the control, while they increased slightly in Group 2.
  
  
  CONCLUSIONS
  Our data suggest that hyperinsulinemia in PCOS is due to a enhanced beta-cell secretion and an impaired hepatic clearance of this hormone, hyperandrogenism may be LH-dependent in Group 1 and insulin-dependent in Group 2.
authors.affiliation: Department of Gynecology, Nanjing Jingling Hospital, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Ke
authors.forename: G Q
authors.initials: GQ
authors.lastname: Shan
authors.forename: S Y
authors.initials: SY
authors.lastname: Hua
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002096:C-Peptide / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000503:physiopathology; D007328:Insulin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood*
chemical_list: D002096:C-Peptide; D007328:Insulin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005947:Glucose