Effect of experimental cryptorchidism on alpha 1-adrenergic receptors of rat testis.
Alpha 1-adrenergic receptors play an important role in the transport of spermatozoa through seminiferous tubules to the efferent ducts leading to the epididymis. The density of alpha 1-adrenergic receptors in adult Sprague-Dawley rat testis before and during 14 days of experimental cryptorchidism was determined by binding assays with [3H]prazosin in membrane preparations. The number of maximal binding sites (Bmax) per milligram protein began to increase at 7 days after surgery (p < .05). The testicular weight and diameter of seminiferous tubules began to decrease at 5 days after surgery (p < .01). However, Bmax per testis did not differ before and during cryptorchidism. This study demonstrates that the density of alpha 1-adrenergic receptors in rat testis is not affected by cryptorchidism.
Sasagawa
I
I
Department of Urology, Yamagata University, School of Medicine, Japan.
Ishigooka
M
M
Kubota
Y
Y
Nakada
T
T
Taniguchi
N
N
D000317:Adrenergic alpha-Antagonists / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D003456:Cryptorchidism / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D007248:Infertility, Male / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D011224:Prazosin / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011942:Receptors, Adrenergic, alpha / Q000032:analysis* / Q000378:metabolism / Q000502:physiology*; D012671:Seminiferous Tubules / Q000378:metabolism / Q000502:physiology; D013737:Testis / Q000737:chemistry* / Q000502:physiology*; D013997:Time Factors; D014316:Tritium
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D014316:Tritium; D011224:Prazosin