Neonatal tolerance revisited: turning on newborn T cells with dendritic cells.
For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.
Ridge
J P
JP
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Fuchs
E J
EJ
Matzinger
P
P
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006182:H-Y Antigen / Q000276:immunology; D007108:Immune Tolerance; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000276:immunology*
D006182:H-Y Antigen