title: Upper gastrointestinal motor abnormalities in children with active celiac disease.
abstract: Although from the clinical point of view a GI motor disorder can be suspected in celiac disease, objective evidence for this is still lacking. We therefore conducted a study on children with active celiac disease to detect possible GI motor abnormalities in this disease. Fourteen children (age range, 1-13 years) were studied; they underwent fasting and fed manometric recordings in the gastroduodenojejunal area. Four patients were restudied after a 6-month gluten-free diet. Data were compared with those obtained in eight control children. As compared with controls, celiac disease patients showed a shorter duration of activity fronts (p < 0.01) and a significant (p < 0.01) reduction of the postprandial antral motility index; furthermore, > 90% of the patients displayed marked fasting and/or fed motor abnormalities, suggesting a neuropathic disorder. Interestingly, gut dysmotilities disappeared in the four subjects reassessed after the gluten-free diet. It is concluded that celiac disease frequently affects the motor behavior of the gut and that its effects may be reversed by appropriate diet.
authors.affiliation: Dipartimento di Pediatria, Università degli Studi di Napoli, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cucchiara
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
authors.forename: G
authors.initials: G
authors.lastname: Castellucci
authors.forename: R
authors.initials: R
authors.lastname: Minella
authors.forename: C
authors.initials: C
authors.lastname: Betti
authors.forename: C
authors.initials: C
authors.lastname: Fusaro
authors.forename: A
authors.initials: A
authors.lastname: Morelli
authors.forename: A
authors.initials: A
authors.lastname: Bertotto
authors.forename: S
authors.initials: S
authors.lastname: Auricchio
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000178:diet therapy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004386:Duodenum / Q000503:physiopathology; D005215:Fasting; D005260:Female; D005502:Food; D005769:Gastrointestinal Motility; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007583:Jejunum / Q000503:physiopathology; D008297:Male
chemical_list: D005983:Glutens