title: Sustained complete cytologic and molecular remission induced by donor leucocyte infusions alone in an acute myeloblastic leukaemia in relapse after bone marrow transplantation.
abstract: Therapeutic options for treatment of recurrence of leukaemia after allogeneic bone marrow transplantation (BMT) are limited. A beneficial effect of donor lymphocyte infusions (DLI) has not previously been described in acute myeloid leukaemia (AML) relapse. We report a case of AML with t(8;21), relapsing 3 months after BMT, who received DLI without adjuvant chemotherapy or growth factors. The patient developed acute GVHD and achieved a rapid complete remission of his AML by both cytologic and molecular criteria of at least 14 months duration, thereby showing that DLI for AML in relapse after BMT is an alternative therapeutic option.
authors.affiliation: Service d'Hématologie Adulte, Hôpital Necker, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Buzyn-Veil
authors.forename: C
authors.initials: C
authors.lastname: Belanger
authors.forename: F
authors.initials: F
authors.lastname: Audat
authors.forename: O
authors.initials: O
authors.lastname: Hermine
authors.forename: C
authors.initials: C
authors.lastname: Bodemer
authors.forename: V
authors.initials: V
authors.lastname: Ribrag
authors.forename: I
authors.initials: I
authors.lastname: Radford
authors.forename: H
authors.initials: H
authors.lastname: Poirel
authors.forename: C
authors.initials: C
authors.lastname: Chane
authors.forename: F
authors.initials: F
authors.lastname: Valensi
authors.forename: E
authors.initials: E
authors.lastname: Macintyre
authors.forename: B
authors.initials: B
authors.lastname: Varet
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D003001:Cloning, Molecular; D003131:Combined Modality Therapy; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D017708:Leukocyte Transfusion; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins; D000075142:RUNX1 Translocation Partner 1 Protein; D012008:Recurrence; D014157:Transcription Factors / Q000235:genetics
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D000075142:RUNX1 Translocation Partner 1 Protein; C082222:RUNX1T1 protein, human; D014157:Transcription Factors