Targeting of motor proteins.
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules. How these proteins are targeted to the appropriate organellar sites within the cell, however, has remained a mystery. Recent work has begun to define the targeting mechanism for two well-studied motor proteins, kinesin and cytoplasmic dynein.
Vallee
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RB
Worcester Foundation for Biomedical Research, Shrewsbury, MA 01545, USA.
Sheetz
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MP
D000818:Animals; D001665:Binding Sites; D001692:Biological Transport; D003593:Cytoplasm / Q000378:metabolism; D000072159:Dynactin Complex; D004398:Dyneins / Q000737:chemistry / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins; D008868:Microtubule Proteins / Q000378:metabolism; D008869:Microtubule-Associated Proteins; D008870:Microtubules / Q000502:physiology*; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism
D000072159:Dynactin Complex; C088547:KTN1 protein, human; D008565:Membrane Proteins; D008868:Microtubule Proteins; D008869:Microtubule-Associated Proteins; D011956:Receptors, Cell Surface; D004398:Dyneins; D016547:Kinesins