[The use of the screening of maternal serum factors for the prenatal diagnosis of fetal developmental defects and chromosomal diseases].
The association of the levels of alpha-fetoprotein and chorionic gonadotropin with congenital developmental defects and chromosomal abnormalities of fetus was studied. The correlation of elevated level of alpha-fetoprotein with defects of neuraxis, kidney and abdominal wall of fetus was shown. These data are used for screening of women with a high risk for Down's syndrome and other chromosomal abnormalities.
Arbuzova
S B
SB
Nikolenko
M I
MI
D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000517:prevention & control*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000517:prevention & control*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods* / Q000706:statistics & numerical data; D014455:Ukraine; D000509:alpha-Fetoproteins / Q000032:analysis*
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins