title: Accumulation of protoporphyrin isomers I and III, and multiple decarboxylation products of uroporphyrin in a case of porphyria in a slaughtered pig.
abstract: Pathological and biochemical examinations were made on tissues from a case of porphyria in a slaughtered pig. Bones, kidneys, teeth and lymph nodes showed a mahogany discoloration. Histologically, the pigment was negative on staining for iron (Gomori) and showed a strong red-orange fluorescence under UV light proving it to be porphyrin. Biochemical studies on the kidney, lymph nodes, bone and bone marrow revealed a 'mixed' erythropoietic protoporphyria-coproporphyria. This indicates that the case presented probably represented both a uroporphyrinogen decarboxylase and uroporphyrinogen-III-cosynthase dysfunction.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Gent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Roels
authors.forename: A
authors.initials: A
authors.lastname: Hassoun
authors.forename: J
authors.initials: J
authors.lastname: Hoorens
mesh_terms: D000003:Abattoirs; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D003653:Decarboxylation; D005260:Female; D007536:Isomerism; D007668:Kidney / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D011164:Porphyrias / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011524:Protoporphyrins / Q000737:chemistry / Q000378:metabolism*; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism* / Q000473:pathology; D014070:Tooth / Q000378:metabolism; D014578:Uroporphyrins / Q000378:metabolism*
chemical_list: D011524:Protoporphyrins; D014578:Uroporphyrins