The effects of in vitro cotitine on nasal ciliary beat frequency.
Cotitine is one of the main metabolites of nicotine. It is stable and in vivo has a relatively long circulating half life. Nasal ciliated cells from non-smoking individuals were exposed in vitro to solutions of cotitine corresponding to serum levels in active and passive smokers. Ciliary beat frequency was measured by a computerized photometric technique. There was a significant drop in ciliary beat frequency compared with control ciliated cells in phosphate buffered saline. It is concluded that cotitine in active or passive smoking has a marked effect on ciliary function. It may be a factor leading to diminished mucociliary clearance and persistent middle ear effusion.
Agius
A M
AM
Department of Otolaryngology, City Hospital NHS Trust, Birmingham, UK.
Wake
M
M
Pahor
A L
AL
Smallman
A
A
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002923:Cilia / Q000187:drug effects; D002925:Ciliary Motility Disorders / Q000139:chemically induced; D003201:Computers; D003367:Cotinine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D009297:Nasal Mucosa / Q000187:drug effects*; D010034:Otitis Media with Effusion / Q000139:chemically induced; D010783:Photometry; D012907:Smoking / Q000009:adverse effects / Q000097:blood; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
D014028:Tobacco Smoke Pollution; D003367:Cotinine