Coat proteins and vesicle budding.
The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving department. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.
Schekman
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Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3202, USA.
Orci
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D001692:Biological Transport; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism; D018699:Coated Vesicles / Q000378:metabolism*; D020756:Coatomer Protein; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism
D002966:Clathrin; D020756:Coatomer Protein; D008565:Membrane Proteins; D011506:Proteins