title: Presence of human immunodeficiency virus (HIV) type 1 and HIV-1-specific antibodies in cervicovaginal secretions of infected mothers and in the gastric aspirates of their infants.
abstract: The presence of human immunodeficiency virus (HIV) in cervicovaginal secretions (CVS) may be a risk factor for perinatal transmission. CVS of 25 women were evaluated for HIV and HIV mucosal antibodies; 16 infants had gastric aspirates cultured. Maternal plasma HIV was measured by quantitative RNA polymerase chain reaction. Seven women (28%), 4 of 19 pregnant and 3 of 7 nonpregnant, had HIV in CVS. Two of 4 HIV-infected neonates had positive gastric aspirate cultures. The 4 pregnant women with HIV in CVS did not transmit infection. HIV-specific secretory IgA was present in CVS of 10 (42%) of 24 women (in 3 cases concurrent with virus). Plasma HIV RNA levels at delivery were higher among transmitters (mean, 68,921 copies/mL) than nontransmitters (mean, 9457 copies/mL). Intermittent HIV shedding in CVS occurred despite mucosal antibodies and did not necessarily correlate with maternal plasma HIV RNA copy number. The presence of HIV in newborn gastric aspirates may be a risk factor for perinatal infection.
authors.affiliation: Department of Pediatrics, UCLA School of Medicine, 90024-1752, USA.
authors.forename: K
authors.initials: K
authors.lastname: Nielsen
authors.forename: P
authors.initials: P
authors.lastname: Boyer
authors.forename: M
authors.initials: M
authors.lastname: Dillon
authors.forename: D
authors.initials: D
authors.lastname: Wafer
authors.forename: L S
authors.initials: LS
authors.lastname: Wei
authors.forename: E
authors.initials: E
authors.lastname: Garratty
authors.forename: R E
authors.initials: RE
authors.lastname: Dickover
authors.forename: Y J
authors.initials: YJ
authors.lastname: Bryson
mesh_terms: D002584:Cervix Uteri / Q000276:immunology / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015483:HIV Antibodies / Q000032:analysis*; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D013270:Stomach / Q000382:microbiology; D014621:Vagina / Q000276:immunology / Q000382:microbiology*
chemical_list: D004279:DNA, Viral; D015483:HIV Antibodies; D007070:Immunoglobulin A; D012367:RNA, Viral