Lyophilized aqueous based polymer matrices for transdermal delivery of captopril.
Transdermal system(s) bearing captopril were developed using a low temperature casting method and aqueous based polymers viz., eudragit RL-100 and polyvinyl pyrrolidone (PVP). The developed system(s) were subjected to an in vitro characterization study. The results were compared with the transdermal systems of the same composition prepared at room temperature. The study revealed that the system(s) prepared using the low temperature casting method performed better in comparison to those prepared at room temperature. The developed system(s) followed zero order release kinetics.
Dubey
B K
BK
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar (M.P.), India.
Katare
O P
OP
Singh
R
R
Jain
S K
SK
D000180:Acrylic Resins; D000279:Administration, Cutaneous; D002102:Cadaver; D002216:Captopril / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005612:Freeze Drying; D006801:Humans; D010539:Permeability; D011108:Polymers; D011205:Povidone; D012867:Skin / Q000378:metabolism
D000180:Acrylic Resins; D011108:Polymers; C050528:Eudragit RS; D002216:Captopril; D011205:Povidone