[Biochemical characteristics of various adaptation mechanisms in acute alcoholic intoxication].
Phase character of metabolic shifts (ethanol, acetaldehyde, catecholamines content, alcohol dehydrogenase and aldehyde dehydrogenase activity) has been revealed in the experiments on white non-inbred rats after a single administration of a sub-narcotic dose of ethanol. Some adaptation-adjustment mechanisms have been established which promote the decrease of the toxic effect of alcohol (induction of activity of alcohol-metabolising enzymes and condensation of acetaldehyde with catecholamines).
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D000079:Acetaldehyde / Q000097:blood*; D000222:Adaptation, Physiological; D000426:Alcohol Dehydrogenase / Q000097:blood; D000444:Aldehyde Dehydrogenase / Q000097:blood; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004837:Epinephrine / Q000097:blood*; D000431:Ethanol / Q000097:blood / Q000506:poisoning*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood*; D051381:Rats
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; D009638:Norepinephrine; D004837:Epinephrine