title: Synthesis and antimicrobial activity of new tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives.
abstract: A series of 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones was synthesized and evaluated for antibacterial and antifungal activity. All of the tested compounds were found active against Staphylococcus aureus and Staphylococcus epidermidis. The compounds were also active against yeast-like fungi and molds where the anticandidal activity of 3a against Candida albicans was superior to the standards miconazole and clotrimazole.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ilhan
authors.forename: G
authors.initials: G
authors.lastname: Capan
authors.forename: N
authors.initials: N
authors.lastname: Ergenç
authors.forename: M
authors.initials: M
authors.lastname: Uzun
authors.forename: M
authors.initials: M
authors.lastname: Kiraz
authors.forename: D
authors.initials: D
authors.lastname: Kaya
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents