Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report.
The case of a patient who developed thrombocytopenia during treatment with carbamazepine (CBZ) is described. The platelet count recovered soon after discontinuation of CBZ, Lymphocyte stimulation test with carbamazepine-10, 11-epoxide (CBZ-10, 11-EPOX), a major metabolite of CBZ, was positive, although with CBZ it was negative. These findings suggest that CBZ-10, 11-EPOX was possibly causative in the pathogenesis of CBZ-induced thrombocytopenia in this case.
Kimura
M
M
Department of Pediatrics, National Nishitottori Hospital, Tottori, Japan.
Yoshino
K
K
Maeoka
Y
Y
Suzuki
N
N
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use*; D002220:Carbamazepine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006429:Hemiplegia / Q000139:chemically induced; D006801:Humans; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis
D000927:Anticonvulsants; D002220:Carbamazepine; C012227:carbamazepine epoxide