Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt.
Hein
L
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Division of Cardiovascular Medicine, Stanford University School of Medicine, California 94305, USA.
Dzau
V J
VJ
Barsh
G S
GS
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D017931:DNA Primers; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016649:Primary Ovarian Insufficiency / Q000235:genetics; D011945:Receptors, Angiotensin / Q000235:genetics*; D014960:X Chromosome
D017931:DNA Primers; D011945:Receptors, Angiotensin