[The electron microscopic study of the cytoplast mitochondria of an ESK cell culture after the action of actinomycin D. Embryonic swine kidney].
The inhibitor of RNA synthesis actinomycin D substantially changed mitochondrial morphology and ultrastructure of cytoplasts in comparison with mitochondria of intact cells. These changes included an increase of matrix condensation, the number of cristae, and extension of intercristal and intracristal spaces. We suggest that mitochondria are characterized by significant independence from the nucleus that possibly controls a considerable part of mitochondrial RNA.
Konstantinova
S A
SA
Shornikova
M V
MV
Neverova
M E
ME
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003593:Cytoplasm / Q000187:drug effects* / Q000648:ultrastructure*; D003609:Dactinomycin / Q000494:pharmacology*; D003864:Depression, Chemical; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects* / Q000648:ultrastructure*; D012313:RNA / Q000187:drug effects / Q000648:ultrastructure; D013552:Swine / Q000196:embryology; D013997:Time Factors
D003609:Dactinomycin; D012313:RNA