title: Adenosine dialdehyde blocks the disappearance of two nerve growth factor-induced insoluble proteins.
abstract: Two nonionic-detergent-insoluble proteins are induced early in the nerve growth factor (NGF)-induced neuronal differentiation of PC12 cells. The pools of these two proteins then disappear from the insoluble fraction after a few days of continued exposure of the cells to NGF. The methylation-inhibiting drug adenosine dialdehyde blocks the disappearance of these insoluble proteins, implicating a methylation-dependent step in the pathway that regulates the fate of these proteins.
authors.affiliation: Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: VanDenburg
authors.forename: P N
authors.initials: PN
authors.lastname: McFadden
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D009363:Neoplasm Proteins / Q000032:analysis / Q000096:biosynthesis*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats; D012995:Solubility
chemical_list: D000963:Antimetabolites; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; C027579:periodate-oxidized adenosine; D000241:Adenosine