title: Endoscopic retrograde cholangiopancreatography in the orthotopic liver transplant patient.
abstract: OBJECTIVE
  Diagnostic imaging of the biliary tract is often required in liver transplant recipients, preoperatively to assess extent of biliary tract disease and postoperatively in patients with a suspected biliary complication due to an abnormal postoperative course.
  
  
  METHODS
  Over a six-year period, 115 patients received 127 liver transplantations at our institution. Twenty-three preoperative ERCPs were performed in 17 patients, while 25 ERCPs were performed on 15 patients after liver transplantation.
  
  
  RESULTS
  Preoperative ERCP in seven of 17 patients revealed a dominant biliary stricture as a result of primary sclerosing cholangitis (PSC); five of these patients were managed successfully with the placement of biliary endoprosthesis. An additional nine patients with PSC underwent brush cytology of the extrahepatic bile ducts to rule out coexisting cholangiocarcinoma; there were no positive results, although three were found to have coexisting cholangiocarcinoma after examination of the explanted liver. Postoperatively, nine of 15 patients were found to have biliary tract disease. These included five biliary strictures (three treated successfully by endoscopic dilation and stent therapy), two biliary leaks (treated by biliary endoprosthesis), one biloma (treated by percutaneous drainage) and one intraductal stone (treated successfully by sphincterotomy and stone extraction). The remaining six patients showed no abnormality at ERCP, and were subsequently diagnosed with allograft rejection.
  
  
  CONCLUSIONS
  Diagnosis of biliary complications after hepatic transplantation is often problematic. Definitive characterization frequently requires cholangiography. Interventional biliary procedures, both endoscopic and percutaneous, can be used successfully to treat these complications; however, surgical revision and retransplantation are sometimes required.
authors.affiliation: Department of Gastroenterology, Cleveland Clinic Foundation, Ohio, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Catalano
authors.forename: J
authors.initials: J
authors.lastname: Van Dam
authors.forename: M V
authors.initials: MV
authors.lastname: Sivak
mesh_terms: D000328:Adult; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000473:pathology; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D012189:Retrospective Studies