Comparative in vitro activity of 11 beta-lactam antibiotics against 91 Staphylococcus intermedius strains isolated from staphylococcal dermatitis in dogs.
A study was made of the susceptibility of 91 strains of Staphylococcus intermedius, isolated from staphylococcal dermatitis of dogs, to 11 beta-lactam antimicrobial agents. The activity of these antimicrobial agents against all strains was tested at pH 7.2 and 8.5. Finally, a comparative study was made of the susceptibility of these micro-organisms, dividing them into six groups: beta-lactamase positive and negative, methicillin resistant and susceptible and oxacillin resistant and susceptible. Only three of the 11 antimicrobial agents studied exhibited satisfactory behaviour at the two pH levels studied: mezlocillin, cefazolin and cefalotine. There was a good correlation at pH 8.5 between methicillin-resistant strains and those resistant to penicillin G, ampicillin, amoxycillin, cefamandole and cefuroxime. This correlation was not observed, however, between oxacillin-resistant strains and strains resistant to the other antimicrobial agents studied.
Piriz
S
S
Cátedra de Microbiología e Inmunología, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
de la Fuente
R
R
Valle
J
J
Mateos
E
E
Hurtado
M A
MA
Cid
D
D
Ruiz-Santaquiteria
J A
JA
Vadillo
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003872:Dermatitis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004352:Drug Resistance, Microbial; D006863:Hydrogen-Ion Concentration; D013207:Staphylococcal Skin Infections / Q000188:drug therapy / Q000662:veterinary*; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases