Leustroduscin B, a new cytokine inducer derived from an actinomycetes, induces thrombocytosis in mice.
Leustroduscin B (LSN-B), a novel colony-stimulating factor (CSF) inducer produced by an actinomycetes, has previously been shown to induce CSF production in bone marrow stromal cells. To determine the biological activity of LSN-B on hematopoiesis in vivo, LSN-B was administered intraperitoneally to mice every day for three to six days. Peripheral platelet counts were markedly elevated on days 4 through 6 compared with the control mice injected with vehicle. Serum II/6 levels were low (0.8 ng/ml) or virtually undetectable in the drug treated groups. This cytokine profile suggests that LSN-B induction of thrombocytosis is mechanistically distinct from other cytokine inducers such as IL-1 or FK-565.
Kohama
T
T
Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Maeda
H
H
Sakai
J I
JI
Shiraishi
A
A
Yamashita
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis; D007783:Lactones / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010976:Platelet Count / Q000187:drug effects; D011753:Pyrones; D013922:Thrombocytosis / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D016207:Cytokines; D015850:Interleukin-6; D007783:Lactones; D009943:Organophosphorus Compounds; D011753:Pyrones; C084414:leustroducsin B