Transgenic approaches to understanding the mechanisms of chemical carcinogenesis in mouse skin.
The use of animal models for human cancer has proved effective in the elucidation of those molecular events which are responsible for the various stages of tumour development. Chemical carcinogenesis in mouse skin has been studied as a model for human squamous cancer for several decades, and analysis of this model has led to the identification of a number of the changes which are involved in the evolution of malignancy. The use of transgenic and knockout mice offers a further avenue of advancement, allowing refinement of the model, and the ability to examine the consequences of individual events in vivo in greater detail. Additionally, crossing different transgenic or knockout animals represents a powerful tool to study the cumulative effects of several genetic alterations acting in concert.
Brown
K
K
CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, Bearsden, UK.
Burns
P A
PA
Balmain
A
A
D000818:Animals; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D012878:Skin Neoplasms / Q000139:chemically induced*; D016211:Transforming Growth Factor alpha / Q000502:physiology
D016211:Transforming Growth Factor alpha