Purely cutaneous Rosai-Dorfman disease.
Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.
Skiljo
M
M
Department of Dermatology, Hospital Virgen de las Nieves, Granada, Spain.
García-Lora
E
E
Tercedor
J
J
Massare
E
E
Esquivias
J
J
García-Mellado
V
V
D005260:Female; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D010587:Phagocytosis; D010950:Plasma Cells / Q000473:pathology; D011506:Proteins / Q000032:analysis; D012075:Remission, Spontaneous; D009418:S100 Proteins / Q000032:analysis; D012871:Skin Diseases / Q000473:pathology*
D011506:Proteins; D009418:S100 Proteins