[Pulmonary function and the pathogenesis of obstructive sleep apnea syndrome].
We studied the relationships between results of pulmonary-function tests and sleep-induced respiratory disorders in men with obstructive sleep apnea syndrome (OSAS). Pulmonary-function tests were done in 23 men with OSAS and in 9 men without OSAS who were matched for age and body mass index. Tests were done both in sitting and in supine positions. For both positions, results of pulmonary-function tests did not differ between the OSAS and the non-OSAS groups. In both groups, %TLC, %FRC, PaO2, and V25/Ht were lower while supine than while sitting, and CC/FRC was higher. In both positions, CC/FRC was significantly and positively correlated with apnea index and with 4% desaturation time. Body mass index was not correlated with apnea index or with 4% desaturation time. These findings suggest that low lung volume and peripheral airway closure contribute to sleep-induced respiratory disorders in men with OSAS, regardless of the body mass index.
Akiba
Y
Y
First Department of Internal Medicine, Asahikawa Medical College, Japan.
Nakano
H
H
Osanai
S
S
Ogasa
T
T
Fujiuchi
S
S
Yamazaki
Y
Y
Nishigaki
Y
Y
Yamaguchi
S
S
Ohsaki
Y
Y
Kikuchi
K
K
D000328:Adult; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology