title: Determinants of persistent detection of human papillomavirus DNA in the uterine cervix.
abstract: To identify factors associated with persistence of human papillomavirus (HPV) DNA in the uterine cervix, 179 women who were 18-49 years old and who had normal cytologies and positive cervical HPV DNA test at a routine periodic examination were analyzed. Among them, 91 (50.8%) remained HPV-positive a few months (mean, 11 weeks) later. Persistence was higher in women who had used oral contraceptives for > or = 2 years (odds ratio, 3.9; 95% confidence interval, 1.5-10.3) compared with those who never used oral contraceptives or used them for <2 years. HPV types 16, 18, and 31/33/35 appeared more persistent (odds ratio, 2.5; 95% confidence interval, 1.0-6.2) than other types. Persistence seemed to increase with virus load and decrease with increasing interval between examinations.
authors.affiliation: Department of Obstetrics and Gynecology, Saint-Sacrement Hospital, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Brisson
authors.forename: I
authors.initials: I
authors.lastname: Bairati
authors.forename: C
authors.initials: C
authors.lastname: Morin
authors.forename: M
authors.initials: M
authors.lastname: Fortier
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
authors.forename: A
authors.initials: A
authors.lastname: Christen
authors.forename: P
authors.initials: P
authors.lastname: Bernard
authors.forename: M
authors.initials: M
authors.lastname: Roy
authors.forename: A
authors.initials: A
authors.lastname: Meisels
mesh_terms: D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D012307:Risk Factors; D013997:Time Factors; D014412:Tumor Virus Infections / Q000175:diagnosis*; D002577:Uterine Cervical Diseases / Q000821:virology*
chemical_list: D004279:DNA, Viral