[4-Arylpiperazine derivatives: a seedbed of drugs for various therapeutic indications].
The main focus of this review is the pharmacology and the therapeutic use of chemical related agents, the arylpiperazine derivatives. These compounds produce a variety of behavioural responses and pharmacological effects which directly and principally result from activation of serotonin systems. However, minor modifications in the chemical structure of these products involve important changes in affinity and selectivity for 5-HT receptors since it can also display significant affinity for dopaminergic, adrenergic or histaminergic receptors. The different arylpiperazine drugs therapeutically used are described as well as some compounds presently under investigation.
Coudert
P
P
Service Pharmacie CHU, Clermont-Ferrand.
Rubat
C
C
Bastide
M
M
Malhuret
R
R
Chopineau
J
J
D000818:Animals; D006801:Humans; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*
D010879:Piperazines