Endosulfan-induced biochemical changes in the testis of rats.
Adult male rats were exposed to 0, 2.5, 5.0 or 10.0 mg endosulfan/kg body weight through oral intubation for 70 d. Decreased sperm counts in the cauda epididymis and reduced intratesticular spermatid counts associated with elevation in the activities of specific testicular marker enzymes (sorbitol dehydrogenase, lactic dehydrogenase, gamma glutamyl transpeptidase, and glucose-6-phosphate dehydrogenase) were seen in all the endosulfan-dosed groups. Endosulfan caused impairment in testicular functions by altering activities of the enzymes responsible for spermatogenesis, thereby influencing intratesticular spermatid count and causing low sperm production and sperm deformity.
Sinha
N
N
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Narayan
R
R
Shanker
R
R
Saxena
D K
DK
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004726:Endosulfan / Q000008:administration & dosage / Q000633:toxicity*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005723:gamma-Glutamyltransferase; D004726:Endosulfan