A human protective protein gene partially overlaps the gene encoding phospholipid transfer protein on the complementary strand of DNA.
The entire human protective protein gene has been cloned, and structural analysis revealed that the gene spans 7.5kb and comprises 15 exons. Furthermore, it partially overlaps on the opposite strand with the gene encoding phospholipid transfer protein. This region of DNA on chromosome 20 appears to encode two distinct mRNAs expressing defined functional products, and the mRNAs overlap by 58 nucleotides at their 3'-untranslated ends.
Shimmoto
M
M
Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science, Japan.
Nakahori
Y
Y
Matsushita
I
I
Shinka
T
T
Kuroki
Y
Y
Itoh
K
K
Sakuraba
H
H
D017398:Alternative Splicing; D001483:Base Sequence; D002268:Carboxypeptidases / Q000096:biosynthesis / Q000235:genetics*; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics*; D043402:Cathepsin A; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002890:Chromosomes, Human, Pair 20; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary / Q000737:chemistry* / Q000378:metabolism; D005091:Exons; D006801:Humans; D007438:Introns; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D049294:Phospholipid Transfer Proteins; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis*; D011994:Recombinant Proteins / Q000096:biosynthesis; D015183:Restriction Mapping
D002352:Carrier Proteins; D017931:DNA Primers; D018076:DNA, Complementary; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D002268:Carboxypeptidases; C468629:CTSA protein, human; D043402:Cathepsin A