Suppression of iron catalyzed free radical generation by iron tyrosinate protein models.
Novel antioxidants, N-(2-Hydroxy-1-naphthal)amino acids which mimic iron proteins, have been intensively studied for suppressive effect on iron-catalyzed free radical generation. These compounds exhibit inhibition of the Fenton reaction in electron spin resonance assessment. In addition, it is shown that the compounds inhibit iron-induced peroxidation by thiobarbituric acid test. Since these antioxidants form stable complexes with Fe3+, this antioxidative activity is expected to be derived from sequestration of catalytic iron.
Kitazawa
M
M
Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210, Japan.
Iwasaki
K
K
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D005609:Free Radicals / Q000737:chemistry; D066298:In Vitro Techniques; D007501:Iron / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000737:chemistry; D018384:Oxidative Stress; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry
D000975:Antioxidants; D005609:Free Radicals; D009942:Organometallic Compounds; D011506:Proteins; D017382:Reactive Oxygen Species; C079518:iron-tyrosinate complex; D014443:Tyrosine; D007501:Iron