Duodenal bicarbonate secretion: eradication of Helicobacter pylori and duodenal structure and function in humans.
OBJECTIVE
Eradication of Helicobacter pylori expedites duodenal ulcer healing and prevents recurrences. Most patients with duodenal ulcers have impaired proximal duodenal mucosal bicarbonate secretion (DMBS). In patients with inactive, healed duodenal ulcers and normal subjects, the effect of H. pylori infection on DMBS and proximal duodenal secretory function and structure were examined.


METHODS
DMBS was quantitated before and after eradication of H. pylori. Mucosal structure (duodenal bulb histopathology) and function (DMBS at rest and stimulated, effect of active vs. healed ulcer and of age) were determined in patients with duodenal ulcers and normal subjects.


RESULTS
In patients with duodenal ulcers, H. pylori eradication normalized proximal DMBS. Histological examination of duodenal biopsy samples was comparable in patients with duodenal ulcers and normal subjects without apparent relationship between inflammation and DMBS. Significantly impaired DMBS occurred in response to all agonists tested (luminal acid, prostaglandin E2, and cephalic-vagal stimulation) in patients with duodenal ulcers, suggesting a generalized secretory defect. Neither the presence of active (vs.inactive) ulcer nor age significantly affected bicarbonate secretion.


CONCLUSIONS
In patients with duodenal ulcers, eradication of H. pylori normalized proximal DMBS and may thereby reduce ulcer recurrences. Altered DMBS in patients with duodenal ulcers was unrelated to histopathologic abnormalities. Impaired bicarbonate secretion in patients with duodenal ulcers could be caused by a cellular and/or physiological regulatory transport defect possibly related to H. pylori.
Hogan
D L
DL
Department of Medicine, University of San Diego, California, USA.
Rapier
R C
RC
Dreilinger
A
A
Koss
M A
MA
Basuk
P M
PM
Weinstein
W M
WM
Nyberg
L M
LM
Isenberg
J I
JI
D000328:Adult; D000367:Age Factors; D000368:Aged; D001639:Bicarbonates / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004386:Duodenum / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence
D001639:Bicarbonates