Biocompatibility of biodegradable and nonbiodegradable polymer-coated stents implanted in porcine peripheral arteries.
OBJECTIVE
To investigate the neointimal response to poly(organo)phosphazene- and amphiphilic polyurethane-coated, oversized, stainless steel stents implanted in porcine peripheral arteries.


METHODS
Nonarticulated, stainless steel, slotted-tube stents were coated with 1) a biodegradable poly-(organo)phosphazene with aminoacid ester side groups and 2) a biostable polyurethane prepared from an amphiphilic polyether, diphenyl methane-4,4'-diisocyanate and butane diol as chain extender. The stents were deployed in porcine peripheral arteries using an oversized balloon.


RESULTS
The neonintimal response to amphiphilic polyurethane-coated stents was similar to the uncoated metallic stents. Poly(organo)phosphazene-coated stents, however, induced a severe histiolymphocytic and fibromuscular reaction resembling a foreign body reaction.


CONCLUSIONS
Amphiphilic polyurethane is very promising as a biocompatible stent coating. Poly-(organo)phosphazene, however, appears unsuitable for this purpose.
De Scheerder
I K
IK
Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
Wilczek
K L
KL
Verbeken
E V
EV
Vandorpe
J
J
Lan
P N
PN
Schacht
E
E
Piessens
J
J
De Geest
H
H
D000800:Angioplasty, Balloon; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D002072:Butylene Glycols / Q000737:chemistry; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000293:injuries / Q000473:pathology*; D017953:Isocyanates / Q000737:chemistry; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009943:Organophosphorus Compounds / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D011859:Radiography; D013193:Stainless Steel; D015607:Stents; D013499:Surface Properties; D013552:Swine; D017539:Tunica Intima / Q000473:pathology; D001559:Benzhydryl Compounds
D001672:Biocompatible Materials; D002072:Butylene Glycols; D017953:Isocyanates; D009943:Organophosphorus Compounds; D011108:Polymers; D011140:Polyurethanes; D013193:Stainless Steel; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds