title: The significance of motor unit variability in sustaining mechanical output of muscle.
abstract: Neuromuscular function and fatigue have been studied using a wide variety of preparations. These range from sections of single fibers from which the cell membrane has been removed to whole muscles or groups of muscles acting about a joint in the intact animal. Each type of preparation has its merits and limitations. There is no ideal preparation; rather the question to be answered will determine the most appropriate model in each case and sometimes a combination of approaches will be needed. In particular, it is important to understand how the mechanical output of whole muscle can be sustained to meet the demands of a task and to take into account the organized variability of the constituent motor units.
authors.affiliation: Department of Muscle and Exercise Physiology, Faculty of Human Movement Sciences, Vrije University, Amsterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Sargeant
authors.forename: D A
authors.initials: DA
authors.lastname: Jones
mesh_terms: D000818:Animals; D006801:Humans; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology