title: Cytogenetic support for primary prostatic cancer in a patient presenting with a soft tissue mass in the leg.
abstract: A 65-year old man presented with a soft tissue mass in the leg, clinically suspect of a sarcoma. Histologic examination suggested a metastatic adenocarcinoma of the prostate, which could not be confirmed by immunohistologic studies. However, cytogenetic analysis strongly supported this diagnosis. A primary prostatic carcinoma was indeed found and the patient died of widely disseminated disease. These findings illustrate the significance of chromosomal analysis in the search for a primary tumor in patients with an unknown primary.
authors.affiliation: Department of Pathology, University Hospital of Groningen, The Netherlands.
authors.forename: W M
authors.initials: WM
authors.lastname: Molenaar
authors.forename: M E
authors.initials: ME
authors.lastname: Stoepker
authors.forename: A J
authors.initials: AJ
authors.lastname: de Ruiter
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D007866:Leg; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000556:secondary