Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats.
Treatment of alloxan diabetic rats with the antioxidant S-allyl cysteine sulfoxide (SACS) isolated from garlic (Allium sativum Linn), ameliorated the diabetic condition almost to the same extent as did glibenclamide and insulin. In addition, SACS controlled lipid peroxidation better than the other two drugs. Furthermore, SACS significantly stimulated in vitro insulin secretion from B cells isolated from normal rats. Hence it can be surmised that the beneficial effects of SACS could be due to both its antioxidant and its secretagogue actions. The former effect is more predominant and the latter is only secondary. These effects highlight the therapeutic value of garlic, which is a component of many diets.
Augusti
K T
KT
Department of Biochemistry, University of Kerala, India.
Sheela
C G
CG
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D005737:Garlic; D005947:Glucose / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism; D006029:Glycosuria; D006321:Heart / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D010946:Plants, Medicinal; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D001786:Blood Glucose; D002374:Catalase; D003545:Cysteine; D005947:Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D007328:Insulin; D013482:Superoxide Dismutase; C006453:alliin