Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1.
Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.
Hromas
R
R
Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA.
Davis
B
B
Rauscher
F J
FJ
Klemsz
M
M
Tenen
D
D
Hoffman
S
S
Xu
D
D
Morris
J F
JF
D001483:Base Sequence; D002888:Chromosomes, Human, Pair 19; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008969:Molecular Sequence Data; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D016335:Zinc Fingers / Q000235:genetics
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; C085969:MZF1 protein, human; D014157:Transcription Factors; D004247:DNA