A prospective randomized trial of the preventive effect of pre-operative transcatheter arterial embolization against recurrence of hepatocellular carcinoma.
To clarify whether pre-operative transcatheter arterial embolization (TAE) improves survival after hepatectomy, a prospective randomized comparative study was done. Of a total of 115 registered patients having solitary hepatocellular carcinoma (HCC) 2 to 5 cm in diameter, 18 (15.7%) were excluded after randomization. As a result, 97 patients were chosen as subjects and divided into two groups: hepatectomy with (group A: n=50) and without (group B: n=47) pre-operative TAE. The period of observation of the patients who survived the surgery was between 4.0 and 6.6 years. The randomization appeared to have provided well-balanced groups of patients and the clinico-pathological characteristics of the two groups were quite similar. The necrotic part of the cancerous lesions, as confirmed by operative specimens, amounted to 74.8+/-33.4% (mean +/-SD) in group A and 6.8+/-7.2% in group B (P<0.01). However, the cancer-free survival rates after hepatectomy in both groups showed little difference (39.1+/-7.0 (%+/-SE) and 31.1+/-0.1, respectively). We speculate that TAE is not effective against such HCC accessory lesions as minute intrahepatic metastasis and tumor thrombus and that pre-operative TAE does not improve post-operative survival.
Yamasaki
S
S
Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Hasegawa
H
H
Kinoshita
H
H
Furukawa
M
M
Imaoka
S
S
Takasaki
K
K
Kakumoto
Y
Y
Saitsu
H
H
Yamada
R
R
Oosaki
Y
Y
Arii
S
S
Okamoto
E
E
Monden
M
M
Ryu
M
M
Kusano
S
S
Kanematsu
T
T
Ikeda
K
K
Yamamoto
M
M
Saoshiro
T
T
Tsuzuki
T
T
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008875:Middle Aged; D011446:Prospective Studies; D016019:Survival Analysis