Perforin-deficient T cells can induce acute graft-versus-host disease after transplantation of MHC-matched or MHC disparate allogeneic bone marrow.
Levy
R B
RB
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA.
Baker
M
M
Podack
E R
ER
D000818:Animals; D016026:Bone Marrow Transplantation; D003602:Cytotoxicity, Immunologic; D006086:Graft vs Host Disease / Q000276:immunology*; D006648:Histocompatibility; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin