title: Late onset undifferentiated seronegative spondyloarthropathy.
abstract: OBJECTIVE
  To define the clinical spectrum of late onset undifferentiated seronegative spondyloarthropathy (uSpA) based on a large number of patients.
  
  
  METHODS
  All consecutive patients older than 45 years at the onset of SpA and not meeting criteria for any of the definite categories of the SpA complex seen in the 1988-1993 period were entered in a special register and were followed prospectively.
  
  
  RESULTS
  Twenty-three patients (mean age at onset 56.9, range 46-72; mean age at the last visit 61.7, range 48-79) were studied. Of these, 12 had 3 or more clinical and/or radiological manifestations of SpA, while 7 showed only 2, and 4 only one. Of the 10 patients with peripheral arthritis, only 3 had the large pitting edema of the lower limbs described by Dubost and Sauvezie. Of the 4 patients with only one manifestation, 2 had peripheral enthesitis and 2 acute anterior uveitis.
  
  
  CONCLUSIONS
  The clinical spectrum of late onset uSpA is as wide as in children and young and middle aged adults.
authors.affiliation: Rheumatic Disease Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Olivieri
authors.forename: A
authors.initials: A
authors.lastname: Padula
authors.forename: A
authors.initials: A
authors.lastname: Pierro
authors.forename: L
authors.initials: L
authors.lastname: Favaro
authors.forename: G S
authors.initials: GS
authors.lastname: Oranges
authors.forename: S
authors.initials: S
authors.lastname: Ferri
mesh_terms: D017668:Age of Onset; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D005208:Fasciitis / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D007592:Joint Diseases / Q000145:classification / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D013122:Spinal Diseases / Q000145:classification / Q000175:diagnosis*; D052256:Tendinopathy / Q000175:diagnosis
chemical_list: D002097:C-Reactive Protein