title: Cleansing efficacy of commercial denture cleansers: ability to reduce Candida albicans biofilm activity.
abstract: A simple method to measure Candidal biofilm activity using pH change of Stomastat was developed and used to evaluate the efficacy of 11 commercial denture cleansers on Candida albicans biofilm. The initial number of yeasts inoculated correlated with the pH value of Stomastat after both 24- and 30-hour incubation periods (r=0.992; r=0.988, respectively; P<.01), which supported the method's validity. The ability of the cleansing agents to decrease fungal biofilm activity varied depending upon the components of the agents. In general, peroxide denture cleansers, a disinfectant, and one enzyme cleanser were more efficacious than the other types tested in this study.
authors.affiliation: Department of Prosthetic Dentistry, School of Dentistry, Hiroshima University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nikawa
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Hamada
authors.forename: S
authors.initials: S
authors.lastname: Sadamori
authors.forename: S
authors.initials: S
authors.lastname: Agrawal
mesh_terms: D000180:Acrylic Resins; D000704:Analysis of Variance; D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D003820:Denture Cleansers / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology; D004798:Enzymes / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010545:Peroxides / Q000494:pharmacology
chemical_list: D000180:Acrylic Resins; D000935:Antifungal Agents; D003820:Denture Cleansers; D004202:Disinfectants; D004798:Enzymes; D010545:Peroxides