[Local arterial infusion of 5-FU in treatment of acute necrotic pancreatitis].
In 19 patients with acute necrotic pancreatitis the cordis tube was inserted in the arterial suppling blood. If the necrotic site at the head of pancreata, the tube was placed in the arteria gastroduodenalis or arteria pancreaticoduodenalis. When the site at the trunk or rearby, the tube was placed in the arteria lienalis or coeliaca, and when the necrosis all over the pancreata, the tube in the arteria coeliaca. Through the tube, infusion drugs mainly 5-FU were given within 20 days from onset of the disease. Compared with the controlled group of 68 patients, the mortalities were 10.5% and 30.9%, and the rates of organ falls 5.3% and 42.7%. The second infection of bacterium was 5.3% and 44.1% respectively. We suggest that local arterial infusion of 5-FU is an effective treatment for acute necrotic pancreatitis and creats conditions for delayed operations, clears the remaining tissue of necrotic pancreatitis easily.
Gu
F
F
Second People's Municipal Hospital of Huzhou, Zhejiang.
Liu
Y
Y
Pan
R
R
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality
D005472:Fluorouracil