Variations of direct fluorescent antibody test and serum bile acids levels following praziquantel treatment in Schistosoma mansoni experimentally infected mice.
This study was performed to evaluate the efficiency and use of an immunopathological test viz "Direct Fluorescent Antibody Test (DFAT) for detection of IgG and IgM deposits in liver and kidney biopsies" and a biochemical test viz "estimation of serum bile acids by enzymatic colorimetric technique" for follow up Schistosoma mansoni infection using Swiss albino mice. Test were done during infection and after Praziquantel (PZQ) treatment. Mice were classified according to the duration of infection and post-therapy periods. It was found that both tests should be used together to provide good parameters to demonstrate S. mansoni infection and to test the regression of the disease after treatment.
Khalil
H M
HM
Department of Parasitology, Faculty of Medicine, Ain-Shams University, Abbassia, Cairo, Egypt.
Bebars
M A
MA
Abdallah
H M
HM
el-Zayyat
E A
EA
Ismail
M S
MS
D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D008297:Male; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D012556:Schistosomicides / Q000627:therapeutic use*; D013997:Time Factors
D001647:Bile Acids and Salts; D012556:Schistosomicides; D011223:Praziquantel