title: Chlorinated hydrocarbons: estrogens and antiestrogens.
abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds bind to the intracellular aryl hydrocarbon (Ah) receptor and induce a diverse spectrum of biochemical and toxic responses. Ah receptor agonists also modulate several endocrine pathways, and research in several laboratories has shown that TCDD and related compounds inhibit estrogen (E2)-induced responses in the rodent mammary and uterus and in human breast cancer cell lines. The mechanisms of interaction between the TCDD- and E2-induced signaling pathways are complex and some of the inhibitory effects may be related to 5'-flanking inhibitory-dioxin responsive elements (i-DREs) in target genes. The antiestrogenic and antitumorigenic activity of Ah receptor agonists has been used to prepare a series of relatively non-toxic alkyl polychlorinated dibenzofurans which have clinical potential for treatment of mammary cancer.
authors.affiliation: Texas A&M University, College Station 77843-4466, USA.
authors.forename: S
authors.initials: S
authors.lastname: Safe
authors.forename: V
authors.initials: V
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D001483:Base Sequence; D004965:Estrogen Antagonists / Q000633:toxicity*; D006801:Humans; D008969:Molecular Sequence Data; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D018336:Receptors, Aryl Hydrocarbon / Q000502:physiology*
chemical_list: D004965:Estrogen Antagonists; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon