Mechanisms of inhibition of DNA polymerases by 2'-deoxyribonucleoside 5'-triphosphate analogs.
Brown
N C
NC
Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655, USA.
Wright
G E
GE
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004256:DNA Polymerase I / Q000037:antagonists & inhibitors; D004257:DNA Polymerase II / Q000037:antagonists & inhibitors; D004259:DNA-Directed DNA Polymerase; D003850:Deoxyribonuclease I; D003854:Deoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D007202:Indicators and Reagents; D008322:Mammals; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship; D013950:Thymus Gland; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D003854:Deoxyribonucleotides; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D019384:Nucleic Acid Synthesis Inhibitors; D014764:Viral Proteins; C069983:gene 43 protein, Enterobacteria phage T4; D004247:DNA; D004256:DNA Polymerase I; D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase; D003850:Deoxyribonuclease I