title: Genetic susceptibility to ozone exposure.
abstract: Because of the impact that oxidizing air pollutants such as ozone (O3) may have on public health, identification of factors that influence susceptibility to exposure remains a critical issue. The role of genetic background as a susceptibility factor is becoming increasingly clear. In this paper, evidence is reviewed which suggests that susceptibility to O3 is a heritable trait in humans. Experimental studies are also described that characterize the mode of inheritance of O3-induced lung injury in inbred strains of mice. It is suggested that future investigations should strive to identify phenotypic markers of susceptibility as a means to identify individuals who are genetically at risk for the development of oxidant-induced lung injury.
authors.affiliation: Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Kleeberger
mesh_terms: D000818:Animals; D001249:Asthma / Q000139:chemically induced; D005823:Genetics; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D008168:Lung / Q000187:drug effects; D051379:Mice; D010126:Ozone / Q000633:toxicity*
chemical_list: D010126:Ozone