Transgenic models of human immunodeficiency virus type-1.
Transgenic models have provided significant insights into HIV-1 pathogenesis, particularly with regards to Kaposi's sarcoma. HIV-associated nephropathy, the tissue-restricted expression of CNS strains of HIV-1, and the function of Nef in vivo. Both multigenic and single gene constructs have contributed to our understanding of HIV-1-induced diseases. While failing to provide models suitable for vaccine development, these transgenic models have provided great insight into HIV pathogenesis and may yet provide a means for the development and testing of molecular based therapies for AIDS.
Klotman
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PE
Mount Sinai Medical Center, Division of Nephrology, New York, NY 10029, USA.
Notkins
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AL
D000818:Animals; D002100:Cachexia / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D015756:Genes, tat; D006130:Growth Disorders / Q000209:etiology; D015658:HIV Infections / Q000209:etiology* / Q000473:pathology; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D051379:Mice; D008822:Mice, Transgenic; D011247:Pregnancy