Nitric oxide in neuronal degeneration.
NO has clearly revolutionized our thinking about aspects of neurotransmission and neuronal signaling. NO is emerging as an important regulator of a variety of physiologic processes; however, under conditions of excessive or inappropriate formation, NO is also emerging as an important mediator of pathologic nervous tissue damage. Uncovering and understanding the targets of NO that contribute to the neuropathologic process will hopefully lead to the development of selective therapeutic agents and to a better understanding of basic processes underlying normal and pathological neuronal functions.
Dawson
V L
VL
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Dawson
T M
TM
D000818:Animals; D006801:Humans; D016202:N-Methylaspartate / Q000633:toxicity; D009410:Nerve Degeneration; D009420:Nervous System / Q000187:drug effects; D009422:Nervous System Diseases / Q000209:etiology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism
D018696:Neuroprotective Agents; D009569:Nitric Oxide; D016202:N-Methylaspartate; D019001:Nitric Oxide Synthase