title: Outcome of patients with brain metastases after combined modality therapy in small cell lung cancer (SCLC): a retrospective study.
abstract: The authors evaluated the role of whole brain radiotherapy (WBRT) on the outcome of brain metastasis and survival in 41 patients with small cell lung cancer (SCLC) treated in their department. In addition to chemotherapy, radiotherapy was given to the primary site in all responder patients. Six patients presented brain metastasis initially and 10 patients after the fourth course of chemotherapy. Brain metastases were symptomatic in 12 of 16 patients with a median time of 5 months (1-14) until symptoms developed. All patients but 2 with brain metastasis received WBRT (30 Gy in 10 fractions) in addition to chemotherapy. The median survival time of patients with brain metastasis was 8.3 months (3.5 to 16) compared to 12 months (4 to 34+) for patients without brain metastasis. In addition, the median survival time for patients with brain metastasis who responded to systemic chemotherapy was better than that of nonresponders. The authors found no improvement in survival in patients who received concomitant WBRT after chemotherapy compared to patients who received WBRT after completion of chemotherapy. In conclusion, the role of consolidating cranial irradiation in addition to chemotherapy in SCLC patients is unclear and warrants prospective randomized studies.
authors.affiliation: Pulmonary Department of Athens University, Sotiria Hospital, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Veslemes
authors.forename: A
authors.initials: A
authors.lastname: Polyzos
authors.forename: P
authors.initials: P
authors.lastname: Latsi
authors.forename: J
authors.initials: J
authors.lastname: Dimitroulis
authors.forename: K
authors.initials: K
authors.lastname: Dimakou
authors.forename: J
authors.initials: J
authors.lastname: Jordanoglou
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome