Origin of circulating group II phospholipase A2 in hepatocytes in a patient with epitheloid hemangioendothelioma of the liver.
The concentration of group II phospholipase A2 was measured in blood plasma samples before and after liver transplantation in a 27-year-old woman who suffered from a massive epitheloid hemangioendothelioma of the liver. The pretransplantation concentration of group II phospholipase A2 was 830 microg/L, which is markedly above the upper limit of the reference interval (10.8 microg/L). After the transplantation, there was a dramatic decrease in the group II phospholipase A2 level (33 microg/L on the first posttransplantation day). In situ hybridization of mRNA and immunohistochemistry revealed synthesis of group II phospholipase A2 in hepatocytes in non-neoplastic areas of the liver. Tumor cells did not contain group II phospholipase A2. The results indicate that group II phospholipase A2 circulating in blood plasma originates in hepatocytes.
Nevalainen
T J
TJ
Department of Pathology, University of Turku, Finland.
Kallajoki
M
M
Pesonen
E
E
Andersson
S
S
Kärkkäinen
P
P
Höckerstedt
K
K
D000328:Adult; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000201:enzymology* / Q000235:genetics / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000601:surgery; D016031:Liver Transplantation / Q000502:physiology; D010741:Phospholipases A / Q000097:blood* / Q000145:classification / Q000235:genetics; D054467:Phospholipases A2; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D010741:Phospholipases A; D054467:Phospholipases A2