title: Aquareovirus interference mediated resistance to infectious hematopoietic necrosis virus.
abstract: This study investigated the stimulation of specific host defenses to IHNV that are created by prior exposure to an avirulent reovirus (chum salmon reovirus; CSV). Preexposure of rainbow trout to CSV for 1 h resulted in a relative percent survival that ranged from 68 to 100% when fish were challenged with IHNV over an 8 week period. The levels of serum neutralizing antibodies detected 28 d after the IHNV challenge were significantly lower among fish receiving prior exposures to CSV than among non-CSV-treated fish. The differences in the humoral response to IHNV in the CSV-treated fish suggested that other immune defense mechanisms may be involved.
authors.affiliation: Clear Springs Foods Inc., Buhl, ID 83316, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: LaPatra
authors.forename: K A
authors.initials: KA
authors.lastname: Lauda
authors.forename: G R
authors.initials: GR
authors.lastname: Jones
mesh_terms: D000818:Animals; D002347:Carps; D002460:Cell Line; D004198:Disease Susceptibility; D005393:Fish Diseases; D007113:Immunity, Innate; D017686:Oncorhynchus mykiss; D012087:Reoviridae / Q000472:pathogenicity*; D012088:Reoviridae Infections / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D012209:Rhabdoviridae / Q000472:pathogenicity*; D018353:Rhabdoviridae Infections / Q000662:veterinary*; D012474:Salmon; D013997:Time Factors