title: [The effect of spermine on protein kinase activity and number of cytosolic estradiol receptors].
abstract: Spermine decreased distinctly the activity of Ca2+ -phospholipid-dependent protein kinases, whereas not affected the protein kinase A activity. Content of cytosol estradiol receptors was drastically decreased in rat uterine in presence of the polyamine. The data obtained and literature data suggest that activation of estradiol receptors appears to occur after phosphorylation by means of Ca2+ - dependent protein kinases, which are regulated via phosphoinositide-involving mechanism, i.e. these receptors acquire the ability to bind hormones.
authors.forename: E S
authors.initials: ES
authors.lastname: Gevorkian
authors.forename: N R
authors.initials: NR
authors.lastname: Akopian
authors.forename: I G
authors.initials: IG
authors.lastname: Artsruni
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Iavorian
mesh_terms: D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005260:Female; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D051381:Rats; D011959:Receptors, Estradiol / Q000187:drug effects* / Q000378:metabolism; D013096:Spermine / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; D011959:Receptors, Estradiol; D013096:Spermine