title: Involvement of the adenylyl cyclase signaling system in the action of insulin and mollusk insulin-like peptide.
abstract: Involvement of the adenylyl cyclase signaling system in the mechanism of action of the mammalian insulin and epidermal growth factor as well as of insulin-like peptide isolated from the bivalve mollusk Anodonta cygnea has been studied. It was shown for the first time that insulin and insulin-like peptide exert in vitro the GTP-dependent stimulating action on the adenylyl cyclase activity. Epidermal growth factor has an analogous effect. Effectiveness of the peptides decreased in the order insulin-like peptide > epidermal growth factor > insulin in the foot smooth muscles of A. cygnea and insulin > epidermal growth factor > insulin-like peptide in the skeletal muscles of rat.
authors.affiliation: Laboratory of Evolution of Biochemical Communication Systems, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Petersburg, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Pertseva
authors.forename: S A
authors.initials: SA
authors.lastname: Plesneva
authors.forename: A O
authors.initials: AO
authors.lastname: Shpakov
authors.lastname: Rusakov YuI
authors.forename: L A
authors.initials: LA
authors.lastname: Kuznetsova
mesh_terms: D000262:Adenylyl Cyclases / Q000187:drug effects*; D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D007328:Insulin; D010446:Peptide Fragments; D004815:Epidermal Growth Factor; D000262:Adenylyl Cyclases