The development of in vivo tracer methods to obtain new information about human disease: a study of the hallucinating brain.
An outline is provided of the development of methodological strategies to address the question of focal cerebral activation during hallucinations in schizophrenic patients. In so doing, the innovation and diligence required to tailor in vivo tracer procedures to specific clinical research issues are highlighted. Attention is drawn to the complexity of methodological advances and the way in which they are based upon close scientific and technical collaboration between clinical scientists, and non-clinical scientists and research support staff.
Jones
T
T
Cyclotron Unit, Medical Research Council Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Silbersweig
D A
DA
Stern
E
E
Schnorr
L
L
Seaward
J
J
Clark
J C
JC
Lammertsma
A A
AA
Grootoonk
S
S
D006212:Hallucinations / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D009068:Movement / Q000502:physiology; D011868:Radioisotopes; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D011868:Radioisotopes