Effects of a single dose and short-term captopril treatment on some pressor and depressor humoral factors in healthy subjects.
14 healthy subjects (8 males and 6 females), aged 25-40 years, were studied before and after oral administration of a single dose of 50 mg captopril as well as after 3 d treatment with 100 mg captopril daily per os. We found that in addition to the well-known effects on the renin-angiotensin-aldosterone system, captopril, after 3 d treatment, significantly increases plasma and urinary kallikrein activity, plasma vasopressin and urinary prostaglandin (PG) E2. Atrial natriuretic peptide did not change significantly after either the single dose or the short-term treatment. We conclude that the blood pressure lowering effect of captopril could be mediated by increasing activity of the kallikrein-kinin system and of PGE2 without any participation of atrial natriuretic peptide.
Zacharieva
S
S
Clinical Centre of Endocrinology and Gerontology, Sofia, Bulgaria.
Orbetzova
M
M
Angelova-Gateva
P
P
Andonova
K
K
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000008:administration & dosage* / Q000494:pharmacology; D015232:Dinoprostone / Q000652:urine; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000378:metabolism / Q000652:urine; D008297:Male; D009994:Osmolar Concentration; D014556:Urine; D014667:Vasopressins / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D014667:Vasopressins; D009320:Atrial Natriuretic Factor; D002216:Captopril; D007610:Kallikreins; D015232:Dinoprostone