T-cell responses in photoimmune therapy.
The extracorporeal inactivation of a lymphocyte rich buffy coat suspension with ultraviolet A light and 8 methoxypsoralen can lead to dramatic clinical improvements following reinfusion of the damaged cells. This therapy is reviewed in the context of the disease it is most commonly used for: cutaneous lymphoma. Studies with cutaneous lymphoma patients have shown an active immune response against purified tumor cells. In addition a mouse model for an impact of therapy on a T-cell lymphoma has demonstrated results that parallel those from clinical studies in humans. The impact of photoimmune therapy on in vivo and in vitro T-cell responses to cutaneous lymphoma is discussed.
Heald
P W
PW
Dermatology Department, Yale University School of Medicine, New Haven, Connecticut, USA.
Kim
H Y
HY
Perez
M
M
Edelson
R L
RL
Berger
C L
CL
D000917:Antibody Formation / Q000187:drug effects; D001804:Blood Transfusion, Autologous; D006801:Humans; D018655:Lymphocyte Count / Q000187:drug effects; D017710:Lymphocyte Transfusion; D008223:Lymphoma / Q000276:immunology; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*