title: Myofibrillar fatigue versus failure of activation.
abstract: Two principal mechanisms underlying fatigue of isolated muscle fibers are described: failure of activation of the contractile system and reduced performance of the myofibrils due to altered kinetics of crossbridge function. The relative importance of these two mechanisms during development of fatigue is discussed.
authors.affiliation: Department of Pharmacology, University of Lund, Sweden.
authors.forename: K A
authors.initials: KA
authors.lastname: Edman
mesh_terms: D000818:Animals; D009119:Muscle Contraction / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000502:physiology*