title: Alterations in skeletal muscle related to short-term impaired physical mobility.
abstract: The purpose of this investigation was to describe and compare two methods of recovery of atrophied skeletal muscle following short-term impaired physical mobility. An animal model was used to study morphologic adaptations of atrophied soleus and plantaris muscles to the effects of 7 days of hind-limb suspension (HS) followed by either sedentary recovery or run training during a 28-day recovery period. Significant atrophy, demonstrated by decreased mean fiber area (MFA, in square micrometers), occurred during the 7-day period of HS. During recovery, MFA returned to control values 14 days earlier in the sedentary compared with the trained groups. Runs training following short-term atrophy induced by HS did not result in the high levels of frank muscle damage and type IIC fibers previously reported following long-term (28-day) atrophy.
authors.affiliation: School of Nursing, University of California, Los Angeles 90095-6918, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Kasper
authors.forename: L C
authors.initials: LC
authors.lastname: Maxwell
authors.forename: T P
authors.initials: TP
authors.lastname: White
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001284:Atrophy / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006614:Hindlimb; D006651:Histocytochemistry; D007103:Immobilization / Q000009:adverse effects*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013997:Time Factors