title: A human RNA polymerase II complex associated with SRB and DNA-repair proteins.
abstract: We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators and increases the activation of transcription. In addition, some components of the RNA polymerase II complex participate in DNA repair.
authors.affiliation: Howard Hughes Medical Institute, Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635, USA.
authors.forename: E
authors.initials: E
authors.lastname: Maldonado
authors.forename: R
authors.initials: R
authors.lastname: Shiekhattar
authors.forename: M
authors.initials: M
authors.lastname: Sheldon
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: R
authors.initials: R
authors.lastname: Drapkin
authors.forename: P
authors.initials: P
authors.lastname: Rickert
authors.forename: E
authors.initials: E
authors.lastname: Lees
authors.forename: C W
authors.initials: CW
authors.lastname: Anderson
authors.forename: S
authors.initials: S
authors.lastname: Linn
authors.forename: D
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D002846:Chromatography, Affinity; D004260:DNA Repair; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D012319:RNA Polymerase II / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000378:metabolism*; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic
chemical_list: D011994:Recombinant Proteins; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D012319:RNA Polymerase II