Effect of H1 and H2 receptor antagonists on the serum activity of gamma-glutamyltransferase during liver regeneration after partial hepatectomy in rats.
Chronic administration of a low dose of the histamine H1 receptor antagonist terfenadine (2 mg/kg/day) induced an increase in gamma-glutamyltransferase serum activity in rats, 360 h after partial hepatectomy while the enzymatic activity appeared not to be affected during liver regeneration following treatment with the histamine H2 receptor antagonist cimetidine (20 mg/kg/day).
Kozlowski
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VA
Ponta Grossa State University, UEPG, Paraná, Brazil.
Mattos Filho
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TR
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D006498:Hepatectomy; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016593:Terfenadine / Q000494:pharmacology; D005723:gamma-Glutamyltransferase / Q000097:blood*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D016593:Terfenadine; D002927:Cimetidine; D005723:gamma-Glutamyltransferase