title: Short- and long-term effects of calcitonin and calcium administration on blood calcium, magnesium and inorganic phosphorus in post menopausal osteoporosis.
abstract: This paper studies the effects of the administration of calcitonin (CT) and Ca on post menopausal osteoporosis, immediately (short-term) and after three months (long-term) of treatment, on total and ionic calcium (Ca), magnesium (Mg), inorganic phosphorus (Pi), calcitonin (CT) and parathyroid hormone (PTH) in plasma. The short-term results show a decrease in total and ionic Ca and Pi four hours after the beginning of the treatment; at seven hours, only Pi varies. A decrease in the total and ionic Ca was observed after three months of CT treatment (long-term effects). No hormonal (PTH and CT) variations were found either in the short or the long-term. However, the PTH/CT ratio decreased significantly during the experiment and this may be an important factor in explaining the long-term Ca variations.
authors.affiliation: Servicio de Bioquímica, Clínica Hospital Clínico Universitario, Zaragoza, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Casao
authors.forename: L M
authors.initials: LM
authors.lastname: Elósegui
authors.forename: M A
authors.initials: MA
authors.lastname: Ibáñez
authors.forename: M D
authors.initials: MD
authors.lastname: Vidal
authors.forename: P
authors.initials: P
authors.lastname: Cervera
authors.forename: J F
authors.initials: JF
authors.lastname: Escanero
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008274:Magnesium / Q000097:blood*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D002116:Calcitonin; D008274:Magnesium; D002118:Calcium