title: Spectrum of 2,836 cases of invasive bacterial or fungal infections in children: results of prospective nationwide five-year surveillance in Finland. Finnish Pediatric Invasive Infection Study Group.
abstract: In a prospective nationwide laboratory-based surveillance study of all invasive bacterial and fungal infections among children < 16 years of age, 2,836 clinical cases were registered during the 5-year period 1985-1989. Of these cases, 136 were polymicrobial. During the study period, nationwide administration of Haemophilus influenzae type b conjugate vaccine reduced the incidence rates of invasive infection caused by this organism. The most common clinical diagnosis (48% of cases) was bacteremia without an identified focus of infection. The age-specific annual incidence rates of all invasive infections in children < or = 15 years of age, in children < or = 4 years of age, in children < or = 1 year of age, and in children < or = 28 days of age were 55.8, 141.4, 272.7, and 2,749.0 cases/100,000 person-years, respectively. Thirty percent of the children in the study had an underlying condition predisposing to infection. The case-fatality rate was 4.1% for all cases of invasive infection.
authors.affiliation: National Public Health Institute, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Saarinen
authors.forename: A K
authors.initials: AK
authors.lastname: Takala
authors.forename: E
authors.initials: E
authors.lastname: Koskenniemi
authors.forename: E
authors.initials: E
authors.lastname: Kela
authors.forename: P R
authors.initials: PR
authors.lastname: Rönnberg
authors.forename: E
authors.initials: E
authors.lastname: Pekkanen
authors.forename: P
authors.initials: P
authors.lastname: Kiiski
authors.forename: J
authors.initials: J
authors.lastname: Eskola
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D016470:Bacteremia / Q000453:epidemiology; D001424:Bacterial Infections / Q000453:epidemiology* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004756:Enterobacteriaceae Infections / Q000453:epidemiology; D005387:Finland / Q000453:epidemiology; D006192:Haemophilus Infections / Q000453:epidemiology / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000494:pharmacology; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009181:Mycoses / Q000453:epidemiology* / Q000401:mortality; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology
chemical_list: D018073:Haemophilus Vaccines