Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol.
Nipradilol, a beta-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilation and plasma nitrite (NO2-) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO2- concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.
Adachi
T
T
Department of Internal Medicine, Keio University, School of Medicine, Tokyo, Japan.
Hori
S
S
Miyazaki
K
K
Takahashi
E
E
Nakagawa
M
M
Udagawa
A
A
Hayashi
N
N
Aikawa
N
N
Ogawa
S
S
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D002395:Catecholamines / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D009573:Nitrites / Q000097:blood*; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D009573:Nitrites; D011412:Propanolamines; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor; C036089:nipradilol; D006152:Cyclic GMP