title: The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice.
abstract: Transgenic animals of the line 8 contain the WAP-SV-T transgene. Females of this line synthesise the SV40 T-antigen in mammary gland epithelial cells during pregnancy and the lactation period. All females are 'milk-less' and the offspring have to be nursed by foster mothers. The reason for this phenomenon is a premature apoptosis during late pregnancy. Nontheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females devlop breast cancer after the first lactation period.
authors.affiliation: Institut für Molekularbiologie und Biochemie der Freien Universität, Berlin, Germany.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Tzeng
authors.forename: K
authors.initials: K
authors.lastname: Gottlob
authors.forename: R
authors.initials: R
authors.lastname: Santarelli
authors.forename: A
authors.initials: A
authors.lastname: Graessmann
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics / Q000502:physiology*; D017209:Apoptosis; D004847:Epithelial Cells; D005260:Female; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000502:physiology; D008325:Mammary Neoplasms, Experimental / Q000209:etiology; D051379:Mice; D008822:Mice, Transgenic; D008894:Milk Proteins / Q000235:genetics; D011247:Pregnancy; D011270:Pregnancy, Animal; D011401:Promoter Regions, Genetic
chemical_list: D000952:Antigens, Polyomavirus Transforming; D008894:Milk Proteins; C024471:whey acidic proteins