A high-resolution genetic map of mouse chromosome 15 encompassing the Dominant megacolon (Dom) locus.
Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra-and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.
Puliti
A
A
Unité INSERM U91. Hôpital Henri Mondor, Créil, France.
Prehu
M O
MO
Simon-Chazottes
D
D
Ferkdadji
L
L
Peuchmaur
M
M
Goossens
M
M
Guénet
J L
JL
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D003433:Crosses, Genetic; D005260:Female; D006627:Hirschsprung Disease / Q000235:genetics*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D018895:Microsatellite Repeats; D009154:Mutation