Synthesis, chemical and pharmacological properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides.
The synthesis and properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides (1-15) are reported. Imide 11, containing 2-hydroxy-3-(4-phenyl-l-piperazinyl) propyl substituent at the nitrogen atom, proved to have the lowest toxicity and, at very high dosages, to be the most pharmacologically active.
Sĺadowska
H
H
Department of Chemistry of Drugs, Wroclaw University of Medicine, Poland.
Potoczek
Sieklucka-Dziuba
M
M
Semczuk
A
A
Kleinrok
Z
Z
D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D005260:Female; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D000661:Amphetamine