[Candida vasculitis].
Apart from direct skin attacks, yeasts of the Candida group hold a place that is much discussed in the occurrence of immuno-allergic reactions of the skin, because of their usual saprophytic characteristics. We report here on observation of a patient of 62 years who presented with a secondary purpuric maculo-papular eruption making a tri-symptom of Gougerot, for which we have incriminated the role of the immunogenicity of Candida. Skin histology confirmed the presence of an angiitis and necrotising capillarity. An intradermal test with candidine reproduced the skin symptoms and histology, whilst other microbial and fungal tests remained within normal limits. Other examinations showed the transitory presence of circulating immune complexes, although the remainder of the immunity factors were negative. A digestive focus of Candida was present. Recovery occurred after systemic mycological treatment was started, though there was a return of symptoms after a temporary initial check.
Bourrain
J L
JL
Service de Dermatologie, CHU de Grenoble.
Béani
J C
JC
Amblard
P
P
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000009:adverse effects*; D002175:Candida / Q000276:immunology* / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008825:Miconazole / Q000627:therapeutic use; D008875:Middle Aged; D012008:Recurrence; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology*
D000935:Antifungal Agents; D000946:Antigens, Fungal; D008825:Miconazole; D000666:Amphotericin B