[The clinical importance of determining nitrates in the blood in patients with disseminated sclerosis].
The blood's nitrates level was estimated in 72 patients with multiple sclerosis. The decrease of blood's nitrate content was observed in patients (2.5 +/- 0.7 mkg/ml) as compared with healthy individuals (14.3 +/- 3.9 mkg/ml). The correlation was found between blood nitrates concentration and clinical current course of disease. The significant blood nitrates content increase was observed during treatment in the case of remittent course of disease in the stage of exacerbation (from 2.9 +/- 0.3 till 5.1 +/- 1.2 mkg/ml) while the absence of such dynamics was marked in progressive type course of disease. The correlation was revealed during treatment between nitrates level and both neurological deficit and vasal alterations (according to ophthalmological data). One may consider patients blood nitrates estimation as quite useful prognostic laboratory test of exacerbation of multiple sclerosis.
Karlov
V A
VA
Khokhlov
A P
AP
Riazantsev
V V
VV
Navasardiants
D G
DG
Savin
A A
AA
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000188:drug therapy; D009566:Nitrates / Q000097:blood*; D011379:Prognosis; D012074:Remission Induction
D009566:Nitrates