[Growth factors in liver regeneration and hepatocarcinogenesis].
Growth factors are pleiotropic, multifunctional cytokines that exert their activity via specific membrane-anchored tyrosine kinases. Growth factors are key regulatory polypeptides in fetal development, wound healing, organ regeneration and are thought to play a major stimulatory role in tumorgenesis. In liver regeneration TGF-alpha and HGF-SF have been identified as activating factors in vivo and their expression and function is tightly regulated. In hepatocarcinogenesis, overexpression of TGF-alpha and IGF-II is frequently present and vast evidence supports their growth stimulatory role at least during later stages of hepatocarcinogenesis.
Schirmacher
P
P
Institut für Pathologie, Universität Mainz.
Odenthal
M
M
Steinberg
P
P
Dienes
H P
HP
D000818:Animals; D002471:Cell Transformation, Neoplastic; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000096:biosynthesis / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000502:physiology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D008115:Liver Regeneration; D016211:Transforming Growth Factor alpha / Q000502:physiology
D006133:Growth Substances; D016211:Transforming Growth Factor alpha; D017228:Hepatocyte Growth Factor