RES-1149-1 and -2, novel non-peptidic endothelin type B receptor antagonists produced by Aspergillus sp. I. Taxonomy of producing strain, fermentation, isolation, and physico-chemical and biological properties.
RES-1149-1 and -2, novel and non-peptidic endothelin antagonists, were isolated from the cultured broth of a fungus, Aspergillus sp. RE-1149. RES-1149-1 and -2 selectively inhibited the ET-1 binding to endothelin type B receptor (ETB receptor) with IC50 values of 1.5 microM and 20 microM, respectively. Taxonomy of producing strains, fermentation, isolation, and physico-chemical properties of RES-1149-1 and -2 are described.
Ogawa
T
T
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Japan.
Ando
K
K
Tanaka
T
T
Uosaki
Y
Y
Matsuda
Y
Y
D000818:Animals; D001230:Aspergillus / Q000145:classification* / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D065128:Endothelin Receptor Antagonists; D005285:Fermentation; D044023:Receptor, Endothelin B; D013764:Tetrahydronaphthalenes / Q000302:isolation & purification*
D065128:Endothelin Receptor Antagonists; C098351:RES 1149-1; C098352:RES 1149-2; D044023:Receptor, Endothelin B; D013764:Tetrahydronaphthalenes