title: [Percutaneous nephrolithotripsy supported by recombinant factor VIII in a patient with hemophilia A, a Jehovah's Witness].
abstract: We reported the use of recombinant factor VIII (rF VIII) On two consecutive occasions of percutaneous nephrolithotripsy (PNL) for treatment of nephro-urethrolithiasis in a patient, a Jehovah's Witness, with hemophilia A. The patient refused blood transfusions but reluctantly accepted treatment with plasma-derived factor VIII concentrates. rF VIII was administered intravenously; 50U/kg just prior to PNL followed by a total dose of 37,500U of rF VIII within a week on each PNL. Hemostasis was complete on two occasions of PNL. The inhibitor to F VIII did not develop. rF VIII is considered to be an extremely useful for management of hemostasis during invasive surgery for patients with hemophilia A who refuse transfusions for religious reasons.
authors.affiliation: Third Department of Internal Medicine, Yamaguchi University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Azuno
authors.forename: K
authors.initials: K
authors.lastname: Kaku
mesh_terms: D000328:Adult; D002835:Christianity; D005169:Factor VIII / Q000627:therapeutic use*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007669:Kidney Calculi / Q000150:complications / Q000628:therapy*; D008096:Lithotripsy / Q000379:methods; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D014514:Ureteral Calculi / Q000150:complications / Q000628:therapy*
chemical_list: D011994:Recombinant Proteins; D005169:Factor VIII