[Improving drug therapy in circulatory insufficiency: the role of renal kallikrein-kinin system].
The renal kallikrein system was studied in 62 patients with coronary heart disease complicated by Functional Classes (FC) I-IV circulatory insufficiency and in 18 apparently healthy individuals. The activity of the renal kallikrein-kinin system was found to decrease in parallel to increases in FC: insignificantly in FC I circulatory disorders and significantly in FG II-IV. The use of captopril in the acute drug test in the first days and after fortnight therapy caused increases in renal kallikrein-kinin activity in patients with FC II-IV circulatory insufficiency and its decreases in FC I. The heterogeneous pattern of time courses of changes in the activity of the renal kallikrein-kinin system appeared in the clinical picture of the disease as captopril-induced hemodynamic and morphofunctional changes in the heart of patients with different FC circulatory insufficiencies.
Komarov
F I
FI
Ol'binskaia
L I
LI
Golokolenova
G M
GM
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D002216:Captopril / Q000008:administration & dosage / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000209:etiology; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology*; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril