[Standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons].
The signs of pneumonic plague in sacred baboons infected by aerosol are: fever, hurried breathing, depression and constantly increasing bacteremia. Some infected animals isolate the plague microbes while coughing and thus could be a source of the infection. By the clinical and pathomorphological signs, pneumonic plague in sacred baboons is similar to that in humans which makes it possible to use the animals in the development of schemes for special prophylaxis and treatment of the disease. In efficacy estimation of antibacterial drugs sacred baboons should be infected by aerosol by highly virulent strains of Y. pestis in doses of 1.10(4)-1.10(5) live microbes. The treatment of the animals should be started from the moment of the rectal temperature increase to 39.5 degrees C or higher after collecting the blood specimens for the bacteriological tests. It was shown that a two-day course of the treatment with antibacterial drugs was not efficient in the animals with pneumonic plague. The use of streptomycin, gentamicin, netilmicin or ciprofloxacin for 7 days cured all the infected animals. The use of streptomycin in the therapeutic doses was not efficient in the animals whose blood specimens of 1 cm3 contained 4.10(4) or more plague microbes by the moment when the treatment was started.
Romanov
V E
VE
Vasil'ev
N T
NT
Shabalin
B A
BA
Mironin
A V
AV
Paramonov
V E
VE
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001833:Body Temperature Regulation / Q000187:drug effects; D002939:Ciprofloxacin / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical / Q000592:standards; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D008171:Lung Diseases / Q000188:drug therapy*; D008297:Male; D008992:Monkey Diseases / Q000188:drug therapy*; D009428:Netilmicin / Q000627:therapeutic use; D010215:Papio; D010930:Plague / Q000188:drug therapy*; D013307:Streptomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005839:Gentamicins; D009428:Netilmicin; D002939:Ciprofloxacin; D013307:Streptomycin