Drug-nutrient interactions.
Nutrition status plays a significant role in a drug's pharmacodynamics. Some disease states and other special conditions affect nutrient status and a drug's therapeutic efficacy. Many classes of drugs, including antimicrobials, hypoglycemics, and hypocholesterolemic agents, can be affected by the presence of food, with the geriatric patient particularly at risk. While a drug's pharmacokinetic profile can usually be predicted, it can be modified by nutrients and by certain pathophysiologic conditions, including aging, hepatic dysfunction, and micronutrients.
Thomas
J A
JA
University of Texas, Health Science Center at San Antonio 78284-7722, USA.
D000367:Age Factors; D000368:Aged; D000924:Anticholesteremic Agents / Q000493:pharmacokinetics; D004347:Drug Interactions; D018565:Food-Drug Interactions; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D009752:Nutritional Status; D010599:Pharmacokinetics
D000924:Anticholesteremic Agents; D007004:Hypoglycemic Agents