title: Sterilisation of Babesia canis infections by imidocarb alone or in combination with diminazene.
abstract: Babesia canis infections were apparently sterilised by a single dose of imidocarb at 7.5 mg kg-1, as well as by a single dose of diminazene at 3.5 mg kg-1, followed by a single dose of imidocarb at 6 mg kg-1 the following day. This was confirmed by subinoculation of blood from these dogs to splenectomised recipients. Sterilisation of the infection is not recommended in endemic areas; a more rational approach would be to allow a state of premunity to develop in dogs at risk to repeated infections.
authors.affiliation: Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort.
authors.forename: B L
authors.initials: BL
authors.lastname: Penzhorn
authors.forename: B D
authors.initials: BD
authors.lastname: Lewis
authors.forename: D T
authors.initials: DT
authors.lastname: de Waal
authors.forename: L M
authors.initials: LM
authors.lastname: López Rebollar
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001404:Babesiosis / Q000188:drug therapy* / Q000276:immunology; D004133:Diminazene / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology; D004285:Dogs; D004359:Drug Therapy, Combination; D007095:Imidocarb / Q000627:therapeutic use*; D007110:Immunity, Active / Q000187:drug effects; D018512:Parasitemia / Q000188:drug therapy* / Q000276:immunology; D014344:Trypanocidal Agents / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D014344:Trypanocidal Agents; D007095:Imidocarb; D004133:Diminazene