title: [Results of myasthenia treatment with methylprednisolone pulses. Preliminary study].
abstract: Eleven patients with generalized myasthenia (type 2b and 3) were studied in whom thymectomy (9 cases) and/or oral steroids did not result in satisfactory improvement. Methylprednisolone was given once a day in an iv slow infusion for five consecutive days (30 mg/kg). In 7 cases this therapy was followed by oral prednisone and/or azathioprine, in 4 cases methylprednisolone infusions were repeated. In all patients a good clinical improvement was achieved immediately after the last infusion or several weeks later. SF EMG examination showed pathological jitter before methylprednisolone treatment in all patients. In 5 of them after therapy the abnormalities in SF EMG were less marked, in 6 patients their intensity did not change, despite good clinical improvement.
authors.affiliation: Kliniki Neurologicznej Akademii Medycznej w Warszawie.
authors.forename: E
authors.initials: E
authors.lastname: Owczarek
authors.forename: B
authors.initials: B
authors.lastname: Emeryk-Szajewska
authors.forename: M
authors.initials: M
authors.lastname: Strugalska-Cynowska
mesh_terms: D000328:Adult; D004576:Electromyography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D008775:Methylprednisolone