Experimental study on the kinetics of mucociliary activity in rabbit airways.
Noninvasive radioaerosol technique was applied to investigate the mucociliary activity of bronchial mucosa using 99mTc-labelled homologous erythrocytes for inhalation. Radioactivity was continuously measured for 60 min with a gamma camera connected online to the computer. Time-activity kinetic parameters were calculated by a monoexponential model. Test substance azelastine and bromhexine were used to demonstrate the validity of experimental method discussed.
Iván
J
J
Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Minker
E
E
Vass
K
K
Láng
J
J
D000280:Administration, Inhalation; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D001964:Bromhexine / Q000494:pharmacology; D001980:Bronchi / Q000502:physiology; D001993:Bronchodilator Agents / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D005100:Expectorants / Q000494:pharmacology; D006207:Half-Life; D007700:Kinetics; D009079:Mucociliary Clearance / Q000187:drug effects / Q000502:physiology*; D009092:Mucous Membrane / Q000502:physiology; D010793:Phthalazines / Q000494:pharmacology; D011817:Rabbits; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects; D013667:Technetium
D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D005100:Expectorants; D010793:Phthalazines; D013667:Technetium; D001964:Bromhexine; C020976:azelastine