title: Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia.
abstract: Trisomy 12 and deletions or translocations of 13q14 are the commonest cytogenetic abnormalities in chronic lymphocytic leukaemia but rarely co-exist in the same patient. We describe eight patients from a series of > 400 patients with CLL in whom trisomy 12 and t or del 13 occur in the same clone. Using FISH we have identified clones with trisomy 12 alone, t or del 13q14 alone and both abnormalities, in each of the patients studied. This implies that neither trisomy 12 nor t or del 13q14 is the initiating event in leukaemogenesis, but does not exclude the possibility of a submicroscopic abnormality of 13q14 occurring as an early event.
authors.affiliation: Department of Haematology, Royal Bournemouth Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Mould
authors.forename: A
authors.initials: A
authors.lastname: Gardiner
authors.forename: M
authors.initials: M
authors.lastname: Corcoran
authors.forename: D G
authors.initials: DG
authors.lastname: Oscier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D005260:Female; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy