The effect of hepatocyte growth factor/scatter factor on human hair follicle growth.
The effect of hepatocyte growth factor/scatter factor (HGF/SF) on human hair follicle growth was examined using a serum-free organ culture system. The DNA synthesis in human hair follicles and elongation of the hair shaft were measured subsequent to the follicle isolation and culture at 31 degrees C in 95% O2-5% CO2 for 72 h. Results showed that HGF/SF significantly increased 3H-thymidine (P < 0.001) incorporation and hair follicle length (P < 0.05). The effect of HGF/SF was dose-dependent with a maximal stimulation at 10 ng/ml.
Jindo
T
T
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
Tsuboi
R
R
Imai
R
R
Takamori
K
K
Rubin
J S
JS
Ogawa
H
H
D000293:Adolescent; D004247:DNA / Q000096:biosynthesis; D018859:Hair Follicle / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D009924:Organ Culture Techniques
D017228:Hepatocyte Growth Factor; D004247:DNA