Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis.
The effects of Ta-383 (0.016, 0.08, 0.4, 2 and 10 mg/kg) and anti-rheumatic drugs (lobenzarit 10 and 50 mg/kg, dexamethasone 0.25 mg/kg) were evaluated on type II collagen-induced arthritis in DBA/1J mice. The arthritis score was markedly suppressed in the groups treated with dexamethasone and TA-383. Serum anti-type II collagen IgG was significantly suppressed in the groups treated with dexamethasone and 0.4 mg/kg TA-383. Histopathological evaluation of the knee joints revealed suppression of the inflammatory changes in the groups treated with dexamethasone and TA-383. These findings suggest that the histopathological examination of the joints of the animal model is useful for the evaluation of anti-rheumatic drugs, and that TA-383 has suppressive effects on type II collagen-induced arthritis, an animal model for human rheumatoid arthritis.
Ueno
M
M
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd, Osaka, Japan.
Imaizumi
K
K
Sugita
T
T
Takata
I
I
Takeshita
M
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D003094:Collagen / Q000276:immunology; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D007074:Immunoglobulin G; D062367:ortho-Aminobenzoates; C083037:2-(4-chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride; D003907:Dexamethasone; D003094:Collagen; C015735:lobenzarit