Mechanism of inhibiting effect of biologically active compounds on the active forms of oxygen reduction.
The impulse voltammetry methods with recording short-living radical-natured products of the reduction (in particular, hydroxyl radicals) are used to study the process of oxygen reduction steps. A possibility to study mechanisms of antioxidative action of biologically active compounds (BAC) through studying their influence on the separate steps of oxygen reduction (initial molecular oxygen, radical particles and peroxides) is shown. It provides a possibility for the purposeful search of BAC capable to affect certain steps of chain oxidation in biosystems.
Gromovaya
V F
VF
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kyiv.
Shapoval
C S
CS
Luik
A I
AI
Piven
V I
VI
D004563:Electrochemistry; D017665:Hydroxyl Radical; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*
D010545:Peroxides; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D010100:Oxygen