title: Impairment of mobility in endodermal cells by FAK deficiency.
abstract: Focal adhesion kinase (FAK) is a novel nonreceptor protein tyrosine kinase that localizes in focal adhesions. It is expressed in a variety of cell types, and we reported earlier that is deficiency causes a decrease of mobility in mesodermal cells with enhanced formation of focal adhesions. With embryoid bodies generated from embryonic stem cells, we also observed a decrease of mobility in FAK-deficient endodermal cells with enhanced focal adhesion formation.
authors.affiliation: Department of Morphogenesis, Kumamoto University School of Medicine, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Ilić
authors.forename: S
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Furuta
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Aizawa
mesh_terms: D000818:Animals; D001483:Base Sequence; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000201:enzymology; D004707:Endoderm / Q000166:cytology* / Q000201:enzymology; D005347:Fibroblasts / Q000166:cytology / Q000201:enzymology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000172:deficiency*; D013234:Stem Cells / Q000166:cytology / Q000201:enzymology
chemical_list: D015815:Cell Adhesion Molecules; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496051:Ptk2 protein, mouse