The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin.
The proopiomelanocortin (POMC) and the corticotropin releasing hormone receptor (CRH-R) genes are expressed in the skin of the C57BL/6 mouse throughout the entire hair cycle, and CRH immunoreactivity is present in the pilosebaceous unit of the hair follicle and the epidermis. These findings suggest that some components of hypothalamo-pituitary axis are operating in mouse skin.
Slominski
A
A
Department of Pathology and Laboratory Medicine, Albany Medical College, NY, 12208, USA.
Ermak
G
G
Hwang
J
J
Mazurkiewicz
J
J
Corliss
D
D
Eastman
A
A
D000818:Animals; D001483:Base Sequence; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D012867:Skin / Q000378:metabolism*
D012333:RNA, Messenger; D018019:Receptors, Corticotropin-Releasing Hormone; D011333:Pro-Opiomelanocortin