Dilemmas in renal transplantation: when the clinical course and histological findings differ.
Histological examination of renal allograft tissue has become the accepted standard in diagnosing acute rejection. We present three cases of allograft dysfunction in which the histological findings and clinical course differed. Reliance on histology alone in therapeutic decision making might have resulted in inappropriate clinical interventions. In renal transplantation, biopsy results must always be interpreted in conjunction with clinical findings.
Curtis
J J
JJ
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, AL 35294-0007, USA.
Julian
B A
BA
Sanders
C E
CE
Herrera
G A
GA
Gaston
R S
RS
D000328:Adult; D001706:Biopsy; D002102:Cadaver; D003937:Diagnosis, Differential; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous