Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein.
We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic mobility, malondialdehyde equivalents and lipid peroxide level of oxidized LDL. On the other hand, Trolox (an analogue of vitamin E) showed less protective effect in the present system. Since free radical mediated oxidation of LDL is implicated to be a cause of atherogenesis, morin hydrate may be a candidate chemotherapeutic agent herein.
Wu
T W
TW
Department of Clinical Biochemistry, University of Toronto, Ontario, Canada.
Fung
K P
KP
Wu
J
J
Yang
C C
CC
Lo
J
J
Weisel
R D
RD
D000578:Amidines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D004586:Electrophoresis; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D047309:Flavones
D000578:Amidines; D000975:Antioxidants; D005419:Flavonoids; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D010545:Peroxides; C049375:perhydroxyl radical; C046728:2,2'-azobis(2-amidinopropane); C008548:morin; D047309:Flavones