title: Metabolic imaging of untreated prostate cancer by positron emission tomography with 18fluorine-labeled deoxyglucose.
abstract: OBJECTIVE
  We evaluated positron emission tomograph (PET) with 18fluorine (18F)-labeled deoxyglucose for metabolic grading of untreated primary prostate cancer, and differentiation of benign and malignant prostatic disease.
  
  
  METHODS
  A total of 48 patients with untreated prostate cancer of different stages and 16 with histologically confirmed benign prostatic hyperplasia (BPH) underwent static PET after intravenous injection of 150 to 300 MBq. 18F-deoxyglucose. 18F-deoxyglucose accumulation was quantitated by calculating differential uptake ratios and prostate-to-skeletal muscle ratios.
  
  
  RESULTS
  Low 18F-deoxyglucose uptake was noted in the majority of primary tumors (81%). 18F-deoxyglucose accumulation did not correlate with increasing tumor grade or stage. There was a significant overlap in uptake values in BPH and malignant prostatic disease. A trend towards statistical significance was noted with lower prostate-to-skeletal muscle ratios in patients with BPH (p < 0.07). Increased 18F-deoxyglucose accumulation was detected in some patients with BPH and malignant prostatic disease, as well as in those with lymph node and bone metastases of prostate cancer.
  
  
  CONCLUSIONS
  18F-deoxyglucose PET does not allow for metabolic labeling in the majority of untreated primary prostate cancers. BPH and primary prostate cancer cannot be reliably differentiated on the basis of PET. Increased 18F-deoxyglucose accumulation occurs in some primary prostate tumors and in metastatic deposits of prostate cancer.
authors.affiliation: Department of Urology, RWTH University of Aachen, Germany.
authors.forename: P J
authors.initials: PJ
authors.lastname: Effert
authors.forename: R
authors.initials: R
authors.lastname: Bares
authors.forename: S
authors.initials: S
authors.lastname: Handt
authors.forename: J M
authors.initials: JM
authors.lastname: Wolff
authors.forename: U
authors.initials: U
authors.lastname: Büll
authors.forename: G
authors.initials: G
authors.lastname: Jakse
mesh_terms: D000963:Antimetabolites; D003847:Deoxyglucose; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000000981:diagnostic imaging / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D000963:Antimetabolites; D005462:Fluorine Radioisotopes; D003847:Deoxyglucose