title: Placental heat shock proteins: no immunohistochemical evidence for a differential stress response in preterm labour.
abstract: The aetiology of idiopathic preterm labour remains obscure. The hypothesis that a stress response induced by low-grade bacterial infection in utero-placental tissues was investigated. Distribution of cognate and inducible isoforms of heat shock proteins (HSP) 70 kD, HSP 60 kD and HSP 90 kD were investigated in an immunohistochemical study of placental and decidual tissues before and after labour at varying gestations. Subjects were pregnant women undergoing singleton delivery after idiopathic preterm labour at less than 34 weeks' gestation (n = 23); spontaneous term labour at 37-42 weeks' gestation (n =24); preterm caesarean sections at less than 34 weeks' gestation for preeclampsia or intrauterine growth retardation (n=14); elective caesarean section at 37-42 weeks' gestation for cephalopelvic disproportion (n = 6). HSP expression was constant throughout the third trimester of pregnancy and did not change following the onset of labour, regardless of gestational age. A stress response in decidual tissues as determined by immunohistochemical analysis is apparently not associated with preterm labour.
authors.affiliation: Department of Clinical Medicine, St. James's University Hospital, Leeds, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Divers
authors.forename: J N
authors.initials: JN
authors.lastname: Bulmer
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: R J
authors.initials: RJ
authors.lastname: Lilford
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000378:metabolism; D018834:Chaperonin 60 / Q000032:analysis / Q000378:metabolism; D003656:Decidua / Q000737:chemistry / Q000378:metabolism; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000032:analysis / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007536:Isomerism; D007752:Obstetric Labor, Premature / Q000209:etiology* / Q000378:metabolism*; D010920:Placenta / Q000737:chemistry* / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism
chemical_list: D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D006360:Heat-Shock Proteins