Occurrence of a T cell lymphoma in a patient with chronic myeloid leukemia treated with alpha interferon.
A patient treated by recombinant human alpha interferon for chronic myeloid leukemia developed a T cell lymphoma. The T cell lymphoma cells were demonstrated to be genotypically different from the chronic myeloid leukemia cells. The possible role of interferon therapy in stimulating T cell proliferation is discussed.
Mahé
B
B
Service d'Hématologie, CHU Hôtel-Dieu, Nantes, France.
Gaillard
F
F
Labadie
F
F
Papin
S
S
Letortorec
S
S
Moreau
P
P
Harousseau
J L
JL
Milpied
N
N
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced / Q000188:drug therapy; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007155:Immunologic Factors / Q000009:adverse effects*; D016130:Immunophenotyping; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000628:therapy*; D016411:Lymphoma, T-Cell, Peripheral / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D011239:Prednisolone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; D007155:Immunologic Factors; D016898:Interferon-alpha; D011239:Prednisolone; D006918:Hydroxyurea