A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis.
A 51-year old woman who had type-C chronic hepatitis developed autoimmune hemolytic anemia after 4 weeks treatment with a total 48 million interferon-beta, 6 million 8 times. Indirect Coomb's test turned from negative to positive through IFN therapy and a complication of asymptomatic primary biliary cirrhosis was confirmed by histologic findings of the biopsied liver which was performed during IFN therapy and a presence of anti-mitochondrial antibody. After stopping IFN therapy and adding prednisolone anemia improved in getting negative indirect Coombs test but remaining positive direct Coombs test.
Kazuta
Y
Y
Department of Internal Medicine, Hanawa Kohsei Hospital, Fukushima, Japan.
Watanabe
N
N
Sagawa
K
K
Kobayashi
H
H
Kojima
T
T
Funabashi
H
H
Moritoh
T
T
Kasukawa
R
R
D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D005260:Female; D006526:Hepatitis C / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects*; D008875:Middle Aged
D016899:Interferon-beta