title: [Treatment of idiopathic and uremic restless legs syndrome with L-dopa--a double-blind cross-over study].
abstract: In a randomized, controlled and double-blind cross-over trial with L-Dopa and placebo we evaluated the effects of a single bedtime dose of L-Dopa 100 to 200 mg on sleep quality and frequency of periodic leg movements (PLM) in 17 patients with idiopathic and in 11 patients with uremic restless legs syndrome (RLS) by polysomnography, actigraphy, and subjective ratings. Treatment with L-Dopa showed significant reduction of the number of periodic leg movements and the PLM-index most pronounced during the first 4 hours of bedtime. Subjective evaluation confirmed improvement of sleep quality. L-Dopa proved to be effective in idiopathic and uremic RLS without any severe side effects.
authors.affiliation: Max-Planck-Institut für Psychiatrie, Klinischen Instituts, München, Deutschland.
authors.forename: T C
authors.initials: TC
authors.lastname: Wetter
authors.forename: C
authors.initials: C
authors.lastname: Trenkwalder
authors.forename: K
authors.initials: K
authors.lastname: Stiasny
authors.forename: T
authors.initials: T
authors.lastname: Pollmächer
authors.forename: J
authors.initials: J
authors.lastname: Kazenwadel
authors.forename: R
authors.initials: R
authors.lastname: Kohnen
authors.forename: M
authors.initials: M
authors.lastname: Künzel
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000187:drug effects; D011788:Quality of Life; D012148:Restless Legs Syndrome / Q000188:drug therapy*; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D014511:Uremia / Q000188:drug therapy*
chemical_list: D007980:Levodopa