Cholecystokinin [corrected] octapeptide modulates dopamine release in rat striatum.
The effect of cholecystokinin octapeptide sulfated (CCK8S) on the basal and electrically evoked release of [3H]dopamine ([3H]DA) in striatal slices from the rat brain was studied. Cholecystokinin octapeptide did not influence the basal release of [3H]DA. Field electrical stimulation (FES) (2 Hz) induced an increase of dopamine release from striatal slices, which was Ca2+ dependent and was abolished by tetrodotoxin, 10(-6) M. Cholecystokinin octapeptide (10(-9) M, 10(-8) M and 10(-7) M) dose dependently reduced the electrically evoked release of [3H]DA. This effect was antagonized by the CCK-A receptor antagonists loxiglumide (10(-7) M, 10(-6) M and 10(-5) M) or proglumide (10(-5) M, 10(-4) M and 10(-3) M). The results suggest that CCK receptors type A are involved in this effect of CCK8S in the striatum.
Rakovska
A
A
Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology; D004558:Electric Stimulation; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D017072:Neostriatum / Q000502:physiology* / Q000648:ultrastructure; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000502:physiology; D012844:Sincalide / Q000502:physiology*; D014316:Tritium
D000897:Anti-Ulcer Agents; D018491:Dopamine Agonists; D006727:Hormone Antagonists; D011949:Receptors, Cholecystokinin; D014316:Tritium; C053737:loxiglumide; D011377:Proglumide; D012844:Sincalide; D001058:Apomorphine; D004298:Dopamine