Dermal cylindroma. An immunohistochemical study of thirteen cases.
Thirteen dermal cylindromas (DC) have been studied immunohistochemically using a panel of antibodies that stain different portions of normal eccrine and apocrine glands. Distinct staining patterns were found in the different cell populations of the tumor. Although the expression of cytokeratins (CK) 19 and 1/10/11 in occasional duct structures could indicate excretory (ductal) differentiation, a link between DC and apocrine secretory coil is suggested by the expression of alpha-1-antichymotrypsin, lysozyme, human milk factor globulin 1, alpha smooth muscle actin (1A4), and CK 8 and 18. The presence of intermingled S-100 protein-, HLA DR-, and CD1a-positive cells argues for the existence of Langerhans cells within the neoplasm. DC shares epithelial membrane antigen, carcinoembryonic antigen, mucin-like carcinoma-associated antigen (B12), laminin, collagen IV, fibronectin, and CD34(QBEND/10) expression with both eccrine and apocrine glands.
Tellechea
O
O
Clínica de Dermatologia, Hospital da Universidade de Coimbra, Portugal.
Reis
J P
JP
Ilheu
O
O
Baptista
A P
AP
D000199:Actins / Q000032:analysis; D000236:Adenoma / Q000473:pathology*; D018949:Antigens, CD1 / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate; D001050:Apocrine Glands / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002454:Cell Differentiation / Q000235:genetics; D003094:Collagen / Q000032:analysis; D004396:Coloring Agents; D004439:Eccrine Glands / Q000473:pathology; D005353:Fibronectins / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000032:analysis / Q000235:genetics; D007797:Laminin / Q000032:analysis; D007801:Langerhans Cells / Q000473:pathology; D018396:Mucin-1 / Q000032:analysis; D009077:Mucins / Q000032:analysis; D009113:Muramidase / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013544:Sweat Gland Neoplasms / Q000473:pathology*; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
D000199:Actins; D018949:Antigens, CD1; D018952:Antigens, CD34; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D004396:Coloring Agents; D005353:Fibronectins; D006684:HLA-DR Antigens; D007797:Laminin; D018396:Mucin-1; D009077:Mucins; D009363:Neoplasm Proteins; D009418:S100 Proteins; D000514:alpha 1-Antichymotrypsin; C057387:mucinous carcinoma-associated antigen; D007633:Keratins; D003094:Collagen; D009113:Muramidase