title: Crohn's disease in children.
abstract: Crohn's disease is a chronic inflammatory condition that may affect any part of the gastrointestinal system and multiple extraintestinal organs. Although its exact pathogenesis remains unknown, increasing evidence suggests an abnormality in the control of "physiologic" inflammation caused by bacterial and other antigens. Diagnosis starts with a careful history and physical examination, and confirmation rests with radiologic and histologic studies. Newer treatments are more specifically targeting the cascade of cytokine-mediated events that perpetuate inflammation.
authors.affiliation: Department of Pediatrics, University of Connecticut School of Medicine, Hartford, 06102, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Hyams
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000636:Aminosalicylic Acids / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000636:Aminosalicylic Acids