Chain migration of neuronal precursors.
In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
Lois
C
C
Rockefeller University, New York 10021, USA.
García-Verdugo
J M
JM
Alvarez-Buylla
A
A
D000818:Animals; D002454:Cell Differentiation; D002462:Cell Membrane / Q000648:ultrastructure; D002465:Cell Movement; D002552:Cerebral Ventricles / Q000166:cytology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008938:Mitosis; D019006:Neural Cell Adhesion Molecules / Q000032:analysis; D009457:Neuroglia / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000648:ultrastructure; D009830:Olfactory Bulb / Q000166:cytology
D005904:Glial Fibrillary Acidic Protein; D019006:Neural Cell Adhesion Molecules