Enhanced activity of the combination of penicillin G and gentamicin against penicillin-resistant viridans group streptococci.
We evaluated the effects of the combination of penicillin G and gentamicin against 10 penicillin-resistant bacteremic isolates of viridans group streptococci for which the MICs of penicillin were 4 to 64 micrograms/ml. In time-kill studies, the combination resulted in more killing of eight isolates for which the MICs of penicillin were from 8 to 64 micrograms/ml than any of the antimicrobial agents tested alone. In general, clearly enhanced antimicrobial activity was observed with the combination.
Cercenado
E
E
Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Díaz
M D
MD
Sánchez-Carrillo
C
C
Vicente
T
T
Bernaldo de Quirós
J C
JC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects*; D013298:Streptococcus sanguis / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D010400:Penicillin G