title: Sterols from the Caribbean sponge Neofibularia nolitangere. Isolation of two novel polyhydroxysteroids.
abstract: The sterol composition of the Caribbean sponge Neofibularia nolitangere has been investigated. In addition to usual sterols this sponge elaborates comparable amounts of 24-methylene-4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (1), which is very unusual among sponge sterols, and lesser quantities of two new polyoxygenated sterols, (24S)-24-ethyl-5 alpha-cholest-8-ene-5,6 beta,7 alpha-triol (2) and (24S)-24-ethyl-5 alpha-cholest-8(14)-ene-5,6 beta,7 alpha-triol (3).
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Naples, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Costantino
authors.forename: E
authors.initials: E
authors.lastname: Fattorusso
authors.forename: A
authors.initials: A
authors.lastname: Mangoni
authors.forename: M
authors.initials: M
authors.lastname: Pansini
mesh_terms: D000818:Animals; D002782:Cholestenes / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid / Q000379:methods; D006914:Hydroxysteroids / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C098162:24-ethylcholest-8(14)-ene-5,6,7-triol; C098163:24-ethylcholest-8-ene-5,6,7-triol; C098161:24-methylene-4-methylcholest-8-en-3-ol; D002782:Cholestenes; D006914:Hydroxysteroids; D013261:Sterols