Linkage analysis with an alternative formulation for the mixed model of inheritance: the finite polygenic mixed model.
This paper presents an extension of the finite polygenic mixed model of Fernando et al. (1994) to linkage analysis. The finite polygenic mixed model, extended for linkage analysis, leads to a likelihood that can be calculated using efficient algorithms developed for oligogenic models. For comparison, linkage analysis of 5 simulated 4021-member pedigrees was performed using the usual mixed model of inheritance, approximated by Hasstedt (1982), and the finite polygenic mixed model extended for linkage analysis presented here. Maximum likelihood estimates of the finite polygenic mixed model could be inferred to be closer to the simulated values in these pedigrees.
Stricker
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C
Institute of Animal Sciences, Swiss Federal Institute of Technology, ETH-Zentrum CLU, Zuerich, Switzerland. stricker@inw.agrl.ethz.ch
Fernando
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RL
Elston
R C
RC
D008040:Genetic Linkage; D005838:Genotype; D008957:Models, Genetic; D010375:Pedigree; D011995:Recombination, Genetic