title: Balanced activation of coagulation and fibrinolysis after a 2-h triathlon.
abstract: To examine whether exercise-induced thrombin formation is accompanied by increased in vivo plasmin formation, we measured molecular markers and neoantigens of the hemostatic system in 10 male subjects (mean 29 yr. range 19-38) before, immediately after, and 2, 8, and 21 h after a triathlon lasting 128-163 min. Thrombin-antithrombin (TAT) complexes, fibrinopeptide A (FPA), and tissue plasminogen activator (t-PA) antigen were maximally increased immediately after exercise and decreased thereafter rapidly. Prothrombin fragment 1 + 2 (PTF1 + 2), fibrin degradation products (FbDP) and plasmin-antiplasmin (PAP) complexes rose to a similar extent 0 and 2 h after exercise decreased thereafter. The maximal levels of PTF1 + 2, TAT, FPA, and FbDP were 1.5-, 2.1-, 1.8-, and 1.9-fold above baseline, respectively. This investigation shows that strenuous prolonged exercise leads to a moderate activation of blood coagulation resulting in thrombin and fibrin formation which is accompanied by a greatly enhanced plasmin generation. It is concluded that the hemostatic of healthy individuals is well kept in balance when stimulated by prolonged strenuous exercise.
authors.affiliation: Department of Sports Medicine, University of Heidelberg, Germany. sportmedizin@krzmail.krz.uni-heidelberg.de
authors.forename: P
authors.initials: P
authors.lastname: Bärtsch
authors.forename: B
authors.initials: B
authors.lastname: Welsch
authors.forename: M
authors.initials: M
authors.lastname: Albert
authors.forename: B
authors.initials: B
authors.lastname: Friedmann
authors.forename: M
authors.initials: M
authors.lastname: Levi
authors.forename: E K
authors.initials: EK
authors.lastname: Kruithof
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000032:analysis; D001642:Bicycling / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis / Q000502:physiology*; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D008297:Male; D012420:Running / Q000502:physiology; D013550:Swimming / Q000502:physiology; D013917:Thrombin / Q000032:analysis; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D000991:Antithrombins; D005344:Fibrinopeptide A; D013917:Thrombin; D010959:Tissue Plasminogen Activator