Lateral and axial signals involved in avian somite patterning: a role for BMP4.
In vertebrates, muscles of the limbs and body wall derive from the lateral compartment of the embryonic somites, and axial muscles derive from the medial compartment. Whereas the mechanisms that direct patterning of somites along the dorsoventral axis are beginning to be understood, little is known about the tissue interactions and signaling molecules that direct somite patterning along the mediolateral axis. We report the identification of a specific marker for the lateral somitic compartment and its early derivatives, cSim1, an avian homolog of the Drosophila single minded gene. Using this marker, we provide evidence that specification of the lateral somitic lineage results from the antagonistic actions of a diffusible medializing signal from the neural tube and a diffusible lateralizing signal from the lateral plate mesoderm, and we implicate bone morphogenetic protein 4(BMP4) in directing this lateralization.
Pourquié
O
O
Institut d'Embryologie du Centre National de la Recherche Scientifique et du Collège de France, Nogent sur Marne.
Fan
C M
CM
Coltey
M
M
Hirsinger
E
E
Watanabe
Y
Y
Bréant
C
C
Francis-West
P
P
Brickell
P
P
Tessier-Lavigne
M
M
Le Douarin
N M
NM
D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D019485:Bone Morphogenetic Proteins; D002490:Central Nervous System / Q000196:embryology; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D017344:Genes, Insect; D005819:Genetic Markers; D018257:Helix-Loop-Helix Motifs / Q000235:genetics / Q000502:physiology; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000196:embryology*; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D011506:Proteins / Q000235:genetics* / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*; D013045:Species Specificity
D051792:Basic Helix-Loop-Helix Proteins; D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005819:Genetic Markers; D009687:Nuclear Proteins; D011506:Proteins; C089449:sim protein, Drosophila