Neuropharmacological effects of ivermectin in mice.
Neuropharmacological effects (Spontaneous locomotor activity, forced locomotor activity and anticonvulsant activity) of invermectin were studied at 400, 800 and 1600 micrograms/kg (administered, subcutaneously). Spontaneous locomotor activity was reduced at all the dose levels but forced locomotor activity was slightly reduced at 800 and 1600 micrograms/kg. The drug did not exhibit any anticonvulsant potential at any of the dose levels studied.
Kanwar
R S
RS
Department of Pharmacology & Toxicology, College of Veterinary & Animal Sciences, HPKV, Palampur.
Varshneya
C
C
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D007559:Ivermectin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects
D000871:Anthelmintics; D000927:Anticonvulsants; D007559:Ivermectin