The use of bilateral adult renal allografts - a method to optimize function from donor kidneys with suboptimal nephron mass.
Alternatives to traditional organ donor usage has allowed expansion of the organ donor pool to help compensate for the increasing disparity between recipients and donors. The use of bilateral adult renal transplants is a novel idea to salvage older donor kidneys with suboptimal nephron mass that would otherwise be destined for discard. Ten renal transplants were performed utilizing both kidneys from adult cadaver donors with diminished nephron mass determined by calculated glomerular filtration rate or biopsy evidence of significant glomerulosclerosis (>10%). Nine of ten (90%) recipients have satisfactory renal function at a mean follow-up of 7 months. The single case of graft failure was due to documented medical non-compliance. Mean serum creatinine at 6 months was 1.5 mg/dl. Mean measured creatinine clearance was 43.2+/-3.4. These preliminary findings suggest that the use of bilateral renal transplants provide satisfactory early function and allows salvage of older donor kidneys with suboptimal nephron mass.
Johnson
L B
LB
The Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kuo
P C
PC
Dafoe
D C
DC
Drachenberg
C B
CB
Schweitzer
E J
EJ
Alfrey
E J
EJ
Ridge
L A
LA
Salvatierra
P
P
Papadimitriou
J C
JC
Mergner
W J
WJ
Bartlett
S T
ST
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D009399:Nephrons / Q000473:pathology; D014019:Tissue Donors; D014184:Transplantation, Homologous