title: Perivascular spaces in eccrine spiradenoma. A clue to its histological diagnosis.
abstract: Perivascular spaces were found to represent a useful histological clue to the diagnosis of eccrine spiradenoma. They were observed in eight of nine eccrine spiradenomas but not in syringomas, nodular basal cell carcinomas, or glomangiomas. Perivascular spaces in spiradenomas consisted of variably sized spaces around one or more central blood vessels, bordered at the periphery by a palisade of tumor cells and lined at both sides by basement membrane collagen type IV. Perivascular spaces contained variable numbers of T lymphocytes in all cases and could undergo fibrosis, cystic dilatation, or hyalinization. In analogy to similar structures in thymomas, we suggest that perivascular spaces in spiradenomas are involved in the traffic of lymphocytes toward the tumor.
authors.affiliation: Department of Pathology II, University Hospital St. Rafael, Katholieke Universiteit Leuven, Belgium.
authors.forename: J J
authors.initials: JJ
authors.lastname: van den Oord
authors.forename: C
authors.initials: C
authors.lastname: De Wolf-Peeters
mesh_terms: D006607:Adenoma, Sweat Gland / Q000098:blood supply* / Q000473:pathology; D001485:Basement Membrane / Q000473:pathology; D001808:Blood Vessels / Q000473:pathology*; D003528:Carcinoma, Adenoid Cystic / Q000098:blood supply; D002280:Basal Cell Carcinoma / Q000098:blood supply; D003094:Collagen; D003560:Cysts / Q000473:pathology; D003937:Diagnosis, Differential; D004108:Dilatation, Pathologic / Q000473:pathology; D005355:Fibrosis; D005918:Glomus Tumor / Q000098:blood supply; D006801:Humans; D006818:Hyalin; D013544:Sweat Gland Neoplasms / Q000098:blood supply* / Q000473:pathology; D018252:Syringoma / Q000098:blood supply; D013601:T-Lymphocytes / Q000473:pathology; D013945:Thymoma / Q000098:blood supply
chemical_list: D003094:Collagen