Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism.
In order to assess the role of vagal nerve afferents in the decrease in food-motivated behavior induced by proinflammatory cytokines, the effects of lipopolysaccharide (LPS, 400 micrograms/kg ip) and recombinant human interleukin-1 beta (IL-1, 750-1500 ng/mouse ip) were tested on nose poke for food in vagotomized and sham-operated mice. Subdiaphragmatic vagotomy attenuated the decrease in response rate induced by IL-1 and LPS. These results suggest that the peripheral immune message is transmitted to the brain via a neural rather than a humoral pathway.
Bret-Dibat
J L
JL
INSERM U394, Bordeaux, France.
Bluthé
R M
RM
Kent
S
S
Kelley
K W
KW
Dantzer
R
R
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005247:Feeding Behavior; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009042:Motivation; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D004731:Endotoxins; D007375:Interleukin-1; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli