title: MR imaging in solvent-induced chronic toxic encephalopathy.
abstract: OBJECTIVE
  To use MR to examine patients with CNS symptoms indicating +chronic intoxication.
  
  
  METHODS
  Thirty-two subjects exposed to industrial solvents for 5 to 28 years and 40 age-matched, healthy controls were examined.
  
  
  RESULTS
  All patients showed decreased signal in the basal ganglia on T2-weighted images. In 11 of the patients the white matter showed diffuse hyperintensity with loss of the grey-white matter discrimination and with distinct periventricular hyperintensities in 5 of the patients. The controls had no pathological changes in the brain.
  
  
  CONCLUSIONS
  Although the relatively small number of patients may obscure the significance, findings observed on T2-weighted images were patchy periventricular hyperintensities and hypointensities in the basal ganglia. Fast spin-echo is a good technique with fast acquisition of images with true spin-echo contrast features.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Linköping, Sweden.
authors.forename: K A
authors.initials: KA
authors.lastname: Thuomas
authors.forename: C
authors.initials: C
authors.lastname: Möller
authors.forename: L M
authors.initials: LM
authors.lastname: Odkvist
authors.forename: U
authors.initials: U
authors.lastname: Flodin
authors.forename: N
authors.initials: N
authors.lastname: Dige
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D016273:Occupational Exposure; D011041:Poisoning / Q000175:diagnosis; D012997:Solvents / Q000633:toxicity*
chemical_list: D012997:Solvents