[Effectiveness of local in vivo application of bleomycetin (bleomycin), chemosorbed on ion exchange medical gauze].
Possible local application of a new dosage form of bleomycetin (bleomycin) with the prolonged action was studied in experimental in vivo models. When the ion exchange textile polymer with the immobilized bleomycetin was implanted subcutaneously to tumor-bearing mice, there was observed marked inhibition of the growth of the following tumors: lung carcinomatosis (LLC), melanoma B-16 and lympholeukemia (NK/Ly). The implants proved to be less toxic by comparison to bleomycetin solutions. The new bleomycetin dosage form is useful as a new delivery system increasing the antibiotic selective action.
Tikhomirov
G A
GA
Bukhman
V M
VM
Prigozhina
M M
MM
Ryltsev
V V
VV
Filatov
V N
VN
D000327:Adsorption; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001458:Bandages; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002277:Carcinoma / Q000188:drug therapy; D004343:Drug Implants; D017136:Ion Transport / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation
D000903:Antibiotics, Antineoplastic; D004343:Drug Implants; D001761:Bleomycin; C025703:bleomycetin