The influence of proline analogs on bleomycin-induced lung injury in rats.
The influence of 3,4-dehydro-DL-proline and 3,4-dehydro-L-proline on lysyl oxidase, prolyl hydroxylase activities, collagen cross-linking and types of collagen in bleomycin-induced lung injury was investigated. Both proline analogs cause a great fall in prolyl hydroxylase activity without effect on lysyl oxidase, diminish the number of cross-links and normalize the type I/type III collagen ratio. It is suggested that proline analogs may be valuable agents in lung fibrosis treatment.
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Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D003094:Collagen / Q000737:chemistry / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001761:Bleomycin; C002195:3,4-dehydroproline; D003094:Collagen; D011392:Proline; D011393:Procollagen-Proline Dioxygenase; D008249:Protein-Lysine 6-Oxidase