title: Familial risk factors for a second primary malignancy in endometrial or ovarian carcinoma.
abstract: OBJECTIVE
  To elucidate the risk factor for a second primary carcinogenesis in endometrial or ovarian carcinoma patients.
  
  
  METHODS
  Endometrial and ovarian carcinoma patients treated from 1975 through 1990 were analyzed clinicopathologically.
  
  
  RESULTS
  The incidence of patients with a second primary malignancy was 10.5% (28/267) in endometrial carcinoma cases, and 9.0% (13/144) in ovarian carcinoma cases. Endometrial carcinoma patients whose parents, siblings, and/or children had developed malignant diseases were at risk for a second primary malignancy. This familial factor is also believed to be a risk factor for ovarian carcinoma patients, but the results lacked statistical significance. There also was no statistical significance with respect to smoking and/or alcohol consumption. More than one-half of the second primary carcinomas were breast, colon, or stomach carcinomas.
  
  
  CONCLUSIONS
  Cancer patients with this familial high-risk factor should be carefully and regularly followed up by monitoring at every anatomic site, especially the breast, stomach, and colon, in order that the development of a second primary carcinoma can be detected as early as possible, and not be overlooked in examinations.
authors.affiliation: Division of Gynecology, Saitama Cancer Center, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shiromizu
authors.forename: J
authors.initials: J
authors.lastname: Araki
authors.forename: T
authors.initials: T
authors.lastname: Onda
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Matsuzawa
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D012307:Risk Factors