Analgesic activity of Psychotria colorata (Willd. ex R. & S.) Muell. Arg. alkaloids.
An ethnopharmacological survey showed that home remedies prepared with flowers, fruits and roots of Psychotria colorata (Wild. ex R. & S.) Muell. Arg. (RUBIACEAE) are used by Amazonian caboclos as pain killers. These data led to the evaluation of analgesic activity of extracts of P. colorata, using the formalin, writhing and tail-flick methods. This paper reports the Naloxone reversible opioid-like analgesic activity of alkaloids present in leafs and flowers of P. colorata.
Elisabetsky
E
E
Departamento de Fisiologia, Universidade Federal do Pará, Belém, Brazil.
Amador
T A
TA
Albuquerque
R R
RR
Nunes
D S
DS
Carvalho
A do C
Ado C
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001938:Brazil; D002845:Chromatography; D002855:Chromatography, Thin Layer; D005557:Formaldehyde; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D010147:Pain Measurement; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011930:Reaction Time; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D000700:Analgesics; D005557:Formaldehyde