[Gingival metastasis of large-cell lung cancer that produced G-CSF].
A 68-year-old man was referred to our hospital for further examination of a gingival mass. Chest radiographs and magnetic resonance imaging disclosed a bulky mass originating in the upper portion of the left lung, in contact with a chronic empyema lesion that first occurred after resection for pulmonary tuberculosis. Examination of a specimen obtained by percutaneous needle biopsy of the mass led to the diagnosis of large-cell carcinoma. Laboratory findings on admission showed marked leukocytosis (48,100/microliter) without evidence of severe a bacterial infection. The level of G-CSF in serum was abnormally high (246 pg/ml, normal value: < 30 pg/ml). Chemotherapy with vindesine, ifosfamide, and cisplatin resulted in shrinkage of the gingival mass, and a decrease in the G-CSF level to 66 pg/ml. Immunohistochemical staining with an anti-G-CSF monoclonal antibody to the primary lung tumor and the gingival mass obtained at autopsy was positive for cytoplasmic G-CSF.
Miyatake
K
K
Department of Medicine, Okayama University Medical School, Japan.
Ueoka
H
H
Tabata
M
M
Shibayama
T
T
Gemba
K
K
Hiyama
J
J
Ohnoshi
T
T
Harada
M
M
Nishii
K
K
Moritani
Y
Y
D000368:Aged; D018287:Carcinoma, Large Cell / Q000378:metabolism* / Q000556:secondary*; D005887:Gingival Neoplasms / Q000378:metabolism* / Q000556:secondary*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male
D016179:Granulocyte Colony-Stimulating Factor