Deleterious effect of formycin A on tumor islet cells.
The adenosine analogue formycin A was recently introduced as a potent insulin secretagogue in normal pancreatic islet cells. In the present study, formycin A was found to inhibit insulin release and to exert a cytotoxic effect in tumor islet cells of the RINm5F line. The latter effect was concentration-related in the 10-100 microM range of formycin A concentrations, not rapidly reversed, and not reproduced by adenosine. This study thus reveals that formycin A may display cytotoxic potential in the same range of concentrations in which it causes a progressive increase of glucose-stimulated insulin secretion in normal pancreatic islets.
Rasschaert
J
J
Laboratory of Experimental Medicine, Brussels Free University, Belgium
Tanigawa
K
K
Malaisse
W J
WJ
D007516:Adenoma, Islet Cell / Q000188:drug therapy*; D000241:Adenosine / Q000031:analogs & derivatives; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005573:Formycins / Q000494:pharmacology*; D007328:Insulin / Q000737:chemistry / Q000378:metabolism; D000078790:Insulin Secretion; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology*; D011506:Proteins / Q000737:chemistry / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005573:Formycins; D007328:Insulin; D011506:Proteins; C034550:formycin; D000241:Adenosine