title: Effects of automatic blood volume control over intradialytic hemodynamic stability.
abstract: Due to the crucial role of hypovolemia in the genesis of dialysis-induced hypotension, we have evaluated whether the automatic control of the intradialytic blood volume (BV) decrease along a preset trajectory might be beneficial to the hemodynamic stability during treatment. Five frequently hypotensive HD patients were studied and a 3-period-protocol (A1-B-A2) was adopted, each period lasting 6 sessions per patient. During the B periods the patient BV decrease was kept along a predefined profile, thanks to an automatic system with a retroactive control of both the ultrafiltration rate (UFR) and dialysate conductivity (DC); instead, during the A periods, conventional HD was performed, with linear UFR and constant DC, inducing a spontaneous decrease in BV. The intradialytic BV behaviour was much more stable during the B-periods (-10.2 +/- 1.4% by the end of the treatment) than during the A1 (-11.2 +/- 3%) and A2 periods (-11.5 +/- 2.5%). Only one dialysis-hypotension episode was observed during the B periods, compared to 8 and 5 during the A1 and A2 periods, respectively (p < 0.05). The automatic control of the BV changes during dialysis could improve the intra-treatment cardiovascular stability in critically-ill patients.
authors.affiliation: Division of Nephrology and Dialysis, Policlinico S. Orsola-Malpighi, Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mancini
authors.forename: A
authors.initials: A
authors.lastname: Santoro
authors.forename: M
authors.initials: M
authors.lastname: Spongano
authors.forename: F
authors.initials: F
authors.lastname: Paolini
authors.forename: P
authors.initials: P
authors.lastname: Zucchelli
mesh_terms: D001676:Biofeedback, Psychology; D001794:Blood Pressure / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D016009:Chi-Square Distribution; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects / Q000592:standards*; D012964:Sodium / Q000097:blood; D014462:Ultrafiltration; D015430:Weight Gain / Q000502:physiology
chemical_list: D012964:Sodium