title: C4 null alleles in a Swedish population.
abstract: The distribution of C4 null alleles (C4Q0) was studied in a Swedish population comprising 410 male individuals from Stockholm County and Uppsala City. The prevalances of homozygous C4A*Q0 and C4B*Q0 determined by analysing the gene products in serum were 5.0 and 5.6%, respectively, in the Stockholm population and 4.0% each in the Uppsala population. These values are higher than those previously reported from other Caucasian populations. The finding reflects a different genetic composition of the Swedish population and may have relevance to the disease spectrum in this population as compared to other Caucasian populations.
authors.affiliation: Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Nityanand
authors.forename: R L
authors.initials: RL
authors.lastname: Dawkins
authors.forename: H
authors.initials: H
authors.lastname: Lithell
authors.forename: G
authors.initials: G
authors.lastname: Holm
authors.forename: A K
authors.initials: AK
authors.lastname: Lefvert
mesh_terms: D000328:Adult; D000483:Alleles; D015934:Complement C4a / Q000235:genetics*; D015935:Complement C4b / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D013548:Sweden
chemical_list: D015934:Complement C4a; D015935:Complement C4b