[Overview--suppression effect of essential trace elements on arteriosclerotic development and it's mechanism].
It is known that the peroxidation of LDL is a trigger for developing arteriosclerosis. The oxidized LDL is produced by either oxidative stress or a few oxidant. Selenium decreased in serum and some organs of stroke-prone spontaneously hypertensive rats (SHRSP), which is a cofactor of glutamine peroxidase. Serum magnesium decreased in patients with diabetes mellitus, with ischemic heart disease, with essential hypertension and with cerebral vascular lesions. Calcium to magnesium ratio was higher in some organs of SHRSP as compared to Wistar Kyoto rats (WKY). These changes accelerated vascular lesions in SHRSP.
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D000818:Animals; D000975:Antioxidants; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D014131:Trace Elements / Q000502:physiology
D000975:Antioxidants; D005609:Free Radicals; D008077:Lipoproteins, LDL; D014131:Trace Elements; D009569:Nitric Oxide