Hypoglycemia increases the gastric emptying rate in healthy subjects.
OBJECTIVE
To compare the gastric emptying rate during normoglycemia with that during insulin-induced hypoglycemia in healthy subjects.


METHODS
In eight healthy subjects, the rate of gastric emptying of an isotope-labeled meal was assessed by a scintigraphic technique during normoglycemia and hypoglycemia, both controlled by an insulin-glucose clamp.


RESULTS
The mean time taken to empty 50% of the test meal from the stomach (T50) for the solid phase was 43.0 +/- 20.0 min during normoglycemia, compared with 16.3 +/- 6.6 min during hypoglycemia, P < 0.001. The mean T50 for the liquid phase was 38.0 +/- 21.2 and 15.4 +/- 10.6 min, respectively, P < 0.001.


CONCLUSIONS
Insulin-induced hypoglycemia increases the gastric emptying rate in healthy subjects.
Schvarcz
E
E
Department of Internal Medicine, Orebro Medical Center Hospital, Sweden.
Palmér
M
M
Aman
J
J
Berne
C
C
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005746:Gastric Emptying; D015309:Glucose Clamp Technique; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D012016:Reference Values; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin