Molecular biology of CNS injury.
Traumatic or ischemic injuries to the central nervous system (CNS) initiate reactive biochemical changes, some of which are autodestructive and others neuroprotective. Identification of these endogenous factors and their regulation will help to clarify mechanisms of secondary tissue damage and may lead to novel therapies. Recently developed molecular approaches offer opportunities for identifying genes involved in these reactive processes. Three types of molecular strategies are reviewed and examples are provided to demonstrate how each may be applied to elucidate basic mechanisms underlying posttraumatic or postischemic death.
Yakovlev
A G
AG
Georgetown University Medical Center, Washington, DC 20007-2197, USA.
Faden
A I
AI
D000818:Animals; D015152:Blotting, Northern; D001930:Brain Injuries / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D005796:Genes; D006801:Humans; D017403:In Situ Hybridization; D009446:Neurobiology / Q000379:methods*; D016133:Polymerase Chain Reaction; D013119:Spinal Cord Injuries / Q000235:genetics / Q000378:metabolism*