title: Hepatocellular carcinoma and cirrhosis. Results of surgical treatment in a European series.
abstract: OBJECTIVE
  The authors analyze the outcomes of patients with hepatocellular carcinoma (HCC) and cirrhosis who underwent liver resections.
  
  
  BACKGROUND
  Liver resection is the best option for HCC arising from hepatic cirrhosis. The experience of Western centers with these patients is shorter than the Asian series.
  
  
  METHODS
  Forty-eight consecutive patients with cirrhosis and HCC who underwent liver resections were studied after a similar diagnostic and therapeutic process. Survival and cumulative recurrence were calculated according to pathologic findings.
  
  
  RESULTS
  Factors influencing survival at 3 years were as follows: type of resection, absence of vascular invasion, size of the tumor, absence of satellite nodules, and the number of nodules. Factors influencing the rate of recurrence at 3 years were the presence of vascular invasion and the presence of satellite nodules. Patients with favorable prognostic factors have a good survival rate with an acceptable recurrence rate.
  
  
  CONCLUSIONS
  Identification of prognostic factors may help in the selection of the appropriate treatment for these patients with HCC and cirrhosis.
authors.affiliation: Department of Surgery, Hospital Clinic, University of Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Fuster
authors.forename: J C
authors.initials: JC
authors.lastname: García-Valdecasas
authors.forename: L
authors.initials: L
authors.lastname: Grande
authors.forename: J
authors.initials: J
authors.lastname: Tabet
authors.forename: J
authors.initials: J
authors.lastname: Bruix
authors.forename: T
authors.initials: T
authors.lastname: Anglada
authors.forename: P
authors.initials: P
authors.lastname: Taurá
authors.forename: A M
authors.initials: AM
authors.lastname: Lacy
authors.forename: X
authors.initials: X
authors.lastname: González
authors.forename: R
authors.initials: R
authors.lastname: Vilana
authors.forename: C
authors.initials: C
authors.lastname: Bru
authors.forename: M
authors.initials: M
authors.lastname: Solé
authors.forename: J
authors.initials: J
authors.lastname: Visa
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery*; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome