Benzastatins A, B, C, and D: new free radical scavengers from Streptomyces nitrosporeus 30643. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
In the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 2.0 and 5.4 microM, respectively.
Kim
W G
WG
Microbial Chemistry Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, Korea.
Kim
J P
JP
Kim
C J
CJ
Lee
K H
KH
Yoo
I D
ID
D000818:Animals; D001549:Benzamides / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D005285:Fermentation; D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D018698:Glutamic Acid / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D011804:Quinolines / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D001549:Benzamides; D016166:Free Radical Scavengers; D011804:Quinolines; C098353:benzastatin A; C098354:benzastatin B; C098356:benzastatin C; C098357:benzastatin D; D018698:Glutamic Acid