Changes of some biochemical and hematological parameters following administration of daunorubicin in rabbits.
The effects of the repeated i.v. administration of daunorubicin (50 mg/m2, once weekly, max. 9 weeks) were investigated in rabbits in vivo to analyze biochemical and hematological changes. Noninvasive polygraphic records were used to evaluate the function of the heart. The administration of daunorubicin induced changes especially in levels of protein (decrease in total protein and albumin) and of some ions (decrease in calcium, magnesium and phosphorus) as well as in hematological parameters (decrease in erythrocytes, leukocytes and thrombocytes). The results obtained correlate with data on mechanisms of daunorubicin toxicity.
Gersl
V
V
Department of Pharmacology, Faculty of Medicine Charles University, Hradec Králové.
Bajgar
J
J
Krs
O
O
Hrdina
R
R
Vávrová
J
J
Palicka
V
V
Voglová
J
J
Cerman
J
J
Suba
P
P
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count / Q000187:drug effects; D001774:Blood Chemical Analysis; D003630:Daunorubicin / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D008297:Male; D011817:Rabbits
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D003630:Daunorubicin