Plasma levels of soluble tumour necrosis factor receptors are increased in coal miners with pneumoconiosis.
Among other cytokines, tumour necrosis factor (TNF)-alpha is considered to play a key role in the development of mineral dust related fibrosis. Previously, we showed that ex-vivo release of TNF by peripheral blood monocytes is a marker for progression of coal workers' pneumoconiosis (CWP). Since soluble TNF receptors (sTNF-Rs) are believed to play an important regulatory role in systemic effects of TNF, we measured plasma levels of sTNF-R55 and sTNF-R75 in coal miners with (n = 28) or without (n = 76) CWP and in nonexposed controls (n = 29). sTNF-R75 levels were significantly increased in miners with CWP (2.09 +/- 0.44 ng.mL-1) versus the nonexposed controls (1.86 +/- 0.23 ng.mL-1). Neither sTNF-R55 nor sTNF-R75 were related to exposure, stage of pneumoconiosis, smoking, or (spontaneous or ex-vivo induced) monocyte TNF-release. sTNF-R55 was increased in subjects with medication (especially those using cardiovascular drugs); upon exclusion of these subjects, sTNF-R55 was found also to be significantly increased in CWP. In conclusion, bearing in mind a confounding effect of medication, soluble TNF receptors are elevated in plasma of retired miners with coal workers' pneumoconiosis. These observations further support the important role of TNF-mediated pathways in the pathogenesis of mineral dust related fibrosis.
Schins
R P
RP
Dept of Health Risk Analysis and Toxicology, University of Limburg, Maastricht, The Netherlands.
Borm
P J
PJ
D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D003032:Coal Mining; D004391:Dust; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D011009:Pneumoconiosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000378:metabolism; D011859:Radiography; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D012822:Silicon Dioxide; D012907:Smoking; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015415:Biomarkers; D004391:Dust; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D012822:Silicon Dioxide