Symptoms of depression in Alzheimer's disease, frontal lobe-type dementia, and subcortical dementia.
These findings support the hypothesis that a frontal-subcortical abnormality is necessary to produce symptoms of depression (e.g., mood-related signs, behavioral disturbances, neurovegetative signs) in dementia. Behavioral disturbances (e.g., disinhibition, agitation, social withdrawal) were more likely to occur in FLTD than in AD or SCD.
Lopez
O L
OL
Department of Neurology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
Gonzalez
M P
MP
Becker
J T
JT
Reynolds
C F
CF
Sudilovsky
A
A
DeKosky
S T
ST
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology; D001479:Basal Ganglia / Q000503:physiopathology*; D003704:Dementia / Q000150:complications* / Q000503:physiopathology; D003863:Depression / Q000209:etiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013788:Thalamus / Q000503:physiopathology*