Scavenging of free-radicals and inhibition of lipid peroxidation by 3-phenylsydnone.
The antioxidant properties of 3-phenylsydnone were studied in various models in-vitro. 3-Phenylsydnone scavenged the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, and inhibited the degradation of deoxyribose mediated by hydroxyl radicals, although, to a lesser extent than trolox, a water soluble analogue of vitamin E. Many antioxidants possess pro-oxidant properties due to their ability to reduce ferric ions; however, 3-phenylsydnone was free from pro-oxidant properties, and also inhibited the lipid peroxidation induced by iron, in rat brain homogenates.
Narla
R S
RS
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Rao
M N
MN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015764:Bepridil / Q000031:analogs & derivatives* / Q000494:pharmacology; D001713:Biphenyl Compounds; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002839:Chromans / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals; D007501:Iron / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects*; D010069:Oxadiazoles / Q000494:pharmacology; D010851:Picrates; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000031:analogs & derivatives
D000975:Antioxidants; D001713:Biphenyl Compounds; D002839:Chromans; D016166:Free Radical Scavengers; D005609:Free Radicals; D010069:Oxadiazoles; D010851:Picrates; D017392:Thiobarbituric Acid Reactive Substances; C098136:3-phenylsydnone; D014810:Vitamin E; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid