title: AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells.
abstract: AIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.
authors.affiliation: Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. middlems@fhs.csu.mcmaster.ca
authors.forename: P J
authors.initials: PJ
authors.lastname: Middlemiss
authors.forename: A J
authors.initials: AJ
authors.lastname: Glasky
authors.forename: M P
authors.initials: MP
authors.lastname: Rathbone
authors.forename: E
authors.initials: E
authors.lastname: Werstuik
authors.forename: S
authors.initials: S
authors.lastname: Hindley
authors.forename: J
authors.initials: J
authors.lastname: Gysbers
mesh_terms: D062365:Aminobenzoates; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007042:Hypoxanthines; D009414:Nerve Growth Factors / Q000502:physiology*; D016501:Neurites / Q000187:drug effects* / Q000648:ultrastructure; D016716:PC12 Cells; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology*; D051381:Rats
chemical_list: D062365:Aminobenzoates; D007042:Hypoxanthines; D009414:Nerve Growth Factors; D011619:Psychotropic Drugs; D011687:Purines; C086241:4-((3-(1,6-dihyro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)benzoic acid