Effects of WIN 35,428 a potent antagonist of dopamine transporter on sleep and locomotor activity in rats.
The new cocaine derivative CFT naphthalene sulphonate (WIN 35,428), has been shown to have a considerably longer duration of action and greater potency than cocaine as a central stimulant and it appears to have a similar mode of action on dopamine (DA) systems. The purpose of the present study was first to investigate the effects of low doses of WIM 35,428 with particular reference to the involvement of dopaminergic system in paradoxical sleep (PS), other sleep parameters and locomotor activity in the rat. WIN 35,428 a potent ligand of dopamine transporter showed biphasic effects upon PS and locomotor activity with low doses increasing and high doses decreasing PS. These changes reflect a functional involvement probably relevant to the action of Win 35,428 on DA transporters.
de Saint Hilaire
Z
Z
IUPG, Service de Neuropsychiatrie, Chêne Bourg, Switzerland.
Python
A
A
Blanc
G
G
Charnay
Y
Y
Gaillard
J M
JM
D000704:Analysis of Variance; D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D003042:Cocaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine; D004298:Dopamine