DNA fingerprinting by hybridisation to oligonucleotide arrays.
Most methods for analysing variation in DNA sequences rely on gel electrophoresis, a method which is difficult to automate and to quantify. Hybridisation to oligonucleotides bound to a solid surface offers alternatives, with the advantage that they can be more readily automated and lend themselves to powerful statistical analytical procedures. In this paper, we discuss a number of different ways in which oligonucleotide arrays could be used for DNA typing for applications in forensic science.
Southern
E M
EM
Department of Biochemistry, University of Oxford, UK.
D000818:Animals; D001331:Automation; D001483:Base Sequence; D005075:Biological Evolution; D016172:DNA Fingerprinting / Q000379:methods*; D005554:Forensic Medicine; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid
D009841:Oligonucleotides