title: Lipopolysaccharide activates the sea urchin immune system.
abstract: Profilin is a small, actin-binding protein that functions at the intersection of signal transduction and cytoskeletal modifications. Increases in the number of profilin messages per cell correlate with sea urchin coelomocytes activation in response to injury. Here we show that coelomocytes respond to immune challenge from lipopolysaccharide with significant elevations in profilin transcripts per coelomyocyte.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena 91125, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Smith
authors.forename: R J
authors.initials: RJ
authors.lastname: Britten
authors.forename: E H
authors.initials: EH
authors.lastname: Davidson
mesh_terms: D000818:Animals; D003285:Contractile Proteins; D007113:Immunity, Innate / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008840:Microfilament Proteins / Q000235:genetics*; D051304:Profilins; D012333:RNA, Messenger / Q000032:analysis*; D012617:Sea Urchins / Q000276:immunology*
chemical_list: D003285:Contractile Proteins; D008070:Lipopolysaccharides; D008840:Microfilament Proteins; D051304:Profilins; D012333:RNA, Messenger