Mucinous (colloid) carcinoma of urinary bladder following long-term cyclophosphamide therapy for Waldenstrom's macroglobulinemia.
Carcinoma of the urinary bladder is a known complication of cyclophosphamide therapy. Almost all such cases have been transitional cell carcinomas. We report here the second example of an adenocarcinoma of bladder and the first purely mucinous (colloid) carcinoma of urinary bladder developing after long-term cyclophosphamide therapy. The patient, a 77-year-old woman, had been treated for Waldenstrom's macroglobulinemia for at least 24 years, during which time treatment for this disease varied from 50 to 100 mg per day. The disease terminated in acute myelogenous leukemia, and she died of severe disseminated intravascular coagulopathy associated with hypermacroglobulinemia. The mucinous (colloid) carcinoma of the urinary bladder was an incidental finding at autopsy.
Siddiqui
A
A
Department of Pathology, New York Medical College, Valhalla 10595, USA.
Melamed
M R
MR
Abbi
R
R
Ahmed
T
T
D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced / Q000473:pathology*; D000368:Aged; D003520:Cyclophosphamide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy*
D003520:Cyclophosphamide