title: Micronuclei in lymphocytes of children from the vicinity of Chernobyl before and after 131I therapy for thyroid cancer.
abstract: The present study addresses the monitoring of children from the Belorussian and Ukrainian Republics exposed to the fall-out of the Chernobyl accident. Micronucleus analysis has been performed on 56 children from different areas. The micronucleus frequencies in individuals as well as in regional groups were comparable with controls, except for three donors. Such results had to be expected, taking into account that at least 7 years have passed since the accident. Most of the children whose micronucleus frequencies were determined are suffering from thyroid cancer and were treated by radioiodine (131I) therapy. We studied the effect of in vitro exposure with 131I on micronucleus induction and that proliferative ability of lymphocytes. The present investigation indicates that micronuclei can be usefully employed to detect individual exposures to the incorporated radionuclide within several days after the intake of the radionuclide in a dose range of around 65-390 mGy (effective dose).
authors.affiliation: Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Wuttke
authors.forename: C
authors.initials: C
authors.lastname: Streffer
authors.forename: W U
authors.initials: WU
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Reiners
authors.forename: J
authors.initials: J
authors.lastname: Biko
authors.forename: E
authors.initials: E
authors.lastname: Demidchik
mesh_terms: D000293:Adolescent; D002648:Child; D002869:Chromosome Aberrations; D004249:DNA Damage / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000648:ultrastructure; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D011210:Power Plants; D018788:Radioactive Hazard Release; D013964:Thyroid Neoplasms / Q000235:genetics*; D013997:Time Factors; D014455:Ukraine
chemical_list: D007457:Iodine Radioisotopes