title: Purely cutaneous Rosai-Dorfman disease.
abstract: Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.
authors.affiliation: Department of Dermatology, Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Skiljo
authors.forename: E
authors.initials: E
authors.lastname: García-Lora
authors.forename: J
authors.initials: J
authors.lastname: Tercedor
authors.forename: E
authors.initials: E
authors.lastname: Massare
authors.forename: J
authors.initials: J
authors.lastname: Esquivias
authors.forename: V
authors.initials: V
authors.lastname: García-Mellado
mesh_terms: D005260:Female; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D010587:Phagocytosis; D010950:Plasma Cells / Q000473:pathology; D011506:Proteins / Q000032:analysis; D012075:Remission, Spontaneous; D009418:S100 Proteins / Q000032:analysis; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D011506:Proteins; D009418:S100 Proteins