title: The role of HLA class II antigens in the induction of cytotoxic T lymphocytes.
abstract: Investigation of pairs of unrelated persons mismatched for a particular HLA-DQB1 or -DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA-DQ and HLA-DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti-DQ and anti-DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA-DQ and HLA-DP antigens play a similar role to HLA-DR specificities in clinical bone marrow transplantation.
authors.affiliation: Department of Immunology, Faculty of Medicine, Comenius University, Bratislava, The Slovak Republic.
authors.forename: V
authors.initials: V
authors.lastname: Demesová
authors.forename: M
authors.initials: M
authors.lastname: Buc
authors.forename: S
authors.initials: S
authors.lastname: Ferencík
authors.forename: T
authors.initials: T
authors.lastname: Sasazuki
authors.forename: I
authors.initials: I
authors.lastname: Shawkatová
authors.forename: S
authors.initials: S
authors.lastname: Porubská
mesh_terms: D005260:Female; D006681:HLA-D Antigens / Q000276:immunology*; D006682:HLA-DP Antigens / Q000276:immunology; D059868:HLA-DP beta-Chains; D006683:HLA-DQ Antigens / Q000276:immunology; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D006681:HLA-D Antigens; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens