A role for STAT family transcription factors in myeloid differentiation.
STAT family transcription factors regulate gene expression in response to a wide variety of cytokines. A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating factor-1 (CSF-1) or during phorbol ester-induced differentiation, was characterized as a 112kDa protein related to, but not identical with known isoforms of STAT 5. Taken together with previously published results, our data suggest an important function for members of the STAT 5 subfamily in regulating gene expression during the process of myeloid differentiation.
Barahmand-pour
F
F
Vienna Biocenter, Institute of Microbiology and Genetics, Austria.
Meinke
A
A
Kieslinger
M
M
Eilers
A
A
Decker
T
T
D000818:Animals; D002460:Cell Line; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
D008222:Lymphokines; D014157:Transcription Factors; C050979:monocyte-macrophage differentiation factor