title: No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants.
abstract: Service station attendants are workers that are definitely exposed to petroleum derivatives. Taking into account that this exposure has been considered to possess genotoxic risk, here we present data on the biomonitoring of a group of 50 service station workers and 43 controls. Micronuclei (MN) from peripheral blood lymphocytes has been considered as the genetic endpoint to be studied and, in addition, data on the concentration of aromatic hydrocarbons at the workplace, urinary metabolites and differential white blood cell count have also been analysed. The results obtained indicate no significant differences between petrol station attendants and controls, when the effects of petrol exposure were investigated by differential white blood cell count and analysis of MN frequencies in phytohaemagglutinin-stimulated lymphocytes. Regarding the urinary metabolites, a significant increase in the phenol level was found in the exposed workers.
authors.affiliation: Grup de Mutagènesi, Unitat de Genètica, Departament de Genètica i deMicrobiologia, Edifici Cn, Universitat Autònoma de Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pitarque
authors.forename: E
authors.initials: E
authors.lastname: Carbonell
authors.forename: N
authors.initials: N
authors.lastname: Lapeña
authors.forename: M
authors.initials: M
authors.lastname: Marsá
authors.forename: M
authors.initials: M
authors.lastname: Torres
authors.forename: A
authors.initials: A
authors.lastname: Creus
authors.forename: N
authors.initials: N
authors.lastname: Xamena
authors.forename: R
authors.initials: R
authors.lastname: Marcos
mesh_terms: D000293:Adolescent; D000328:Adult; D001554:Benzene / Q000032:analysis; D002478:Cells, Cultured; D005742:Gasoline / Q000009:adverse effects*; D006626:Hippurates / Q000652:urine; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010578:Petroleum / Q000009:adverse effects*; D019800:Phenol; D010636:Phenols / Q000652:urine; D010835:Phytohemagglutinins / Q000494:pharmacology; D012307:Risk Factors; D014050:Toluene / Q000032:analysis; D014992:Xylenes / Q000032:analysis
chemical_list: D005742:Gasoline; D006626:Hippurates; D010578:Petroleum; D010636:Phenols; D010835:Phytohemagglutinins; D014992:Xylenes; D019800:Phenol; D014050:Toluene; D001554:Benzene; C030514:hippuric acid