Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats.
1. The efficacy of HI-6 and obidoxime in combination with atropine on cyclohexyl methylphosphonofluoridate (GF)-induced cholinergic and stressogenic effects in rats was studied. 2. HI-6 sufficiently reactivated cholinesterase activity in blood as well as acetylcholinesterase activity in brain and diaphragm following GF intoxication, and practically eliminated stressogenic effects of GF (an increase in plasma corticosterone level and liver tyrosine aminotransferase activity). 3. Obidoxime had practically no effect on enzyme activity or stressogenic effects of GF agent. 4. These findings confirm that HI-6 has definite advantages over obidoxime in the treatment of intoxication with GF.
Kassa
J
J
Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.
Bajgar
J
J
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000008:administration & dosage / Q000494:pharmacology*; D002802:Cholinesterases / Q000097:blood; D003345:Corticosterone / Q000097:blood; D003964:Diaphragm / Q000187:drug effects / Q000201:enzymology; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009768:Obidoxime Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D010091:Oximes; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014444:Tyrosine Transaminase / Q000378:metabolism
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; D009768:Obidoxime Chloride; D001285:Atropine; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; D002802:Cholinesterases; C022870:asoxime chloride; C053914:cyclohexyl methylphosphonofluoridate; D003345:Corticosterone