[Experimental induction of abnormalities by the instillation of ethanol in embryonated eggs of chickens (Gallus gallus)].
The teratogenic effect of alcohol on chick embryos has been confirmed by many investigators. However, how this occurs is unknown. The aim of this study was to establish a teratogenic pattern of alcohol effects, on the first stages of development in avians. Fertilized eggs were infused through the air space of the shell on day 0, with ethanol in concentrations of 20%, 40% and 60%. The control group was infused with 0.1 ml of NaCl at 0.9%. At a second stage, the eggs were treated on the 4th day of incubation, using the same method. In both groups the eggs were removed on the 11th day of incubation. The teratological manifestations that appeared more frequently were evisceration, haemorrhagic embryos, oedema, cranial deformities, lack of eyes, and umbilical hernia, showing every embryo a clear reduction in size and body weight.
Illanes
J
J
Departamento de Morfología y Embriología Experimental Facultad de Medicina Universidad de Chile.
Blanquez
M J
MJ
Gonzalez
M E
ME
Rojo
C
C
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002642:Chick Embryo / Q000187:drug effects* / Q000254:growth & development; D000431:Ethanol / Q000633:toxicity*
D000431:Ethanol