Relaxin is not related to symptom-giving pelvic girdle relaxation in pregnant women.
BACKGROUND
The pregnancy associated hormone relaxin induces loosening of the pelvic ligaments in several species. This study was undertaken to evaluate whether pregnant women with symptom-giving girdle relaxation had increased serum relaxin concentrations during pregnancy.


METHODS
Serum relaxin concentrations were measured in 38 pregnant women with symptom-giving pelvic girdle relaxation at the time of diagnosis, in the 30th and 38th week of pregnancy as well as 2 and 6 months after delivery. Fourteen pregnant women without symptoms served as a control group. Relaxin concentrations were measured by a homologous enzyme linked immuno-sorbent assay. All participants were clinically examined including tests for symptom-giving pelvic girdle relaxation.


RESULTS
No differences in serum relaxin concentrations were found throughout pregnancy and after delivery.


CONCLUSIONS
The present results do not suggest an important role for relaxin in symptom-giving pelvic girdle relaxation during human pregnancy.
Hansen
A
A
Department of Rheumatology, Herlev Hospital, University of Copenhagen, Denmark.
Jensen
D V
DV
Larsen
E
E
Wilken-Jensen
C
C
Petersen
L K
LK
D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017699:Pelvic Pain / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology*; D012063:Relaxation / Q000502:physiology; D012065:Relaxin / Q000096:biosynthesis / Q000097:blood*
D012065:Relaxin