Use of decimal assay for additivity to demonstrate synergy in pair combinations of econazole, nikkomycin Z, and ibuprofen against Candida albicans in vitro.
Interactions between six compounds (econazole, miconazole, amphotericin B, nystatin, nikkomycin Z, and ibuprofen) were investigated for their antifungal activities against Candida albicans by using pair combinations in an in vitro decimal assay for additivity based on disk diffusion. Additive interactions were observed between miconazole and econazole, amphotericin B and nystatin, and amphotericin B and ibuprofen, while an antagonistic interaction was observed between econazole and amphotericin B. Synergistic interactions were recorded for the combinations of econazole and ibuprofen, econazole and nikkomycin Z, and ibuprofen and nikkomycin Z.
Tariq
V N
VN
School of Biology and Biochemistry, Queen's University of Belfast, Northern Ireland, United Kingdom.
Scott
E M
EM
McCain
N E
NE
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004357:Drug Synergism; D004464:Econazole / Q000494:pharmacology*; D007052:Ibuprofen / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004464:Econazole; C011952:nikkomycin; D007052:Ibuprofen