title: The current role of prophylactic mastectomy.
abstract: Prophylactic mastectomy has a role in preventing breast cancer in the woman at high risk. The rare indications for this operation are based on genetic and histologic factors that affect relative or cumulative risk. Evaluation of women at high risk must draw on multidisciplinary expertise, including genetic counseling. If prophylactic mastectomy is recommended, skin-sparing total mastectomy (not subcutaneous) with autogenous tissue reconstruction is the preferred approach.
authors.affiliation: Department of Surgery, Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lopez
authors.forename: K A
authors.initials: KA
authors.lastname: Porter
mesh_terms: D019313:BRCA1 Protein; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008408:Mastectomy; D009363:Neoplasm Proteins; D012307:Risk Factors; D014157:Transcription Factors
chemical_list: D019313:BRCA1 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors