[A new oxa-analog of myristic acid, suppressing replication of the human immunodeficiency virus].
A series of oxaanalogs of myristic acid were synthesized and tested for antiviral activity in MT4 cells infected with human immunodeficiency virus 1 (HIV-1). The synthesized acids have no toxic effect on uninfected MT4 cells at a concentration of 100 microM. 14,14,14-Trifluoro-12-oxatetradecanoic acid substantially (by 75%) inhibits the reproduction of HIV-1. Other compounds synthesized, (7Z)-13-, (9Z)-13-, and (7Z)-11-oxatetradecenoic acids, exhibit no antiviral effect.
Vodovozova
E L
EL
Mikhalev
I I
II
Rzhaninova
A A
AA
Garaev
M M
MM
Molotkovskiĭ
Iu G
IuG
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D019814:Myristic Acid; D009227:Myristic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010100:Oxygen / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D009227:Myristic Acids; D019814:Myristic Acid; D010100:Oxygen