Localization of the Darier disease gene to a 2-cM portion of 12q23-24.1.
Positional cloning with microsatellite markers allowed further localization of the Darier disease gene to a 2-cM interval of chromosome 12, 12q23-24.1, between the polymorphic loci D12S234 and D12S129. A region this size is suitable for construction of a contig to identify the Darier disease gene. Use of a polymorphic intronic marker for nitric oxide synthetase 1 gene, which maps to the same chromosomal area as the Darier gene, allowed exclusion of that gene as the Darier disease gene.
Wakem
P
P
Department of Dermatology, University of Rochester, NY 14642, USA.
Ikeda
S
S
Haake
A
A
Polakowska
R
R
Ewing
N
N
Sarret
Y
Y
Duvic
M
M
Berg
D
D
Bassett
A
A
Kennedy
J L
JL
Tuskis
A
A
Epstein
E H
EH
Goldsmith
L A
LA
D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D007644:Darier Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree