Influence of anti-IgG antibodies on graft outcome in live related donor renal transplantation.
To study the role of pretransplant IgG anti-F(ab)2 gamma and IgG anti-Fc antibodies on the outcome of live related donor (LRD) kidney transplantation, serum samples from 60 recipients and 20 normal controls (NC) were tested using enzyme immunoassay. Patients with well-functioning grafts (WFG) after 1 year of follow-up had significantly higher IgG anti-F(ab)2 gamma activity expressed as mean optical density measured at 405 nm, i.e. 0.426 +/- 0.06 as compared to NC (0.167 +/- 0.046) or patients undergoing reversible rejection (RR) (0.145 +/- 0.043) and irreversible rejections (IR) (0.26 +/- 0.01). However, patients with IR had higher IgG anti-Fc activity (0.424 +/- 0.2) than the WFG group (0.1 +/- 0.02) and NC (0.095 +/- 0.02), with the RR group values in between (0.248 +/- 0.06). The same trend was observed when the data were analysed according to the serum creatinine levels. We conclude that in the LRD renal transplant situation, pretransplant serum IgG anti-F(ab)2 gamma activity has a protective effect on graft survival while IgG anti-Fc has a detrimental effect on graft outcome.
Tahir
M T
MT
Department of Histocompatibility and Immunogenetics, All India Institute of Medical Sciences, New Delhi.
Mehra
N K
NK
D000888:Antibodies, Anti-Idiotypic / Q000145:classification / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology*; D009679:Nuclear Family; D010290:Parents; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; C048844:anti-IgG; D003404:Creatinine