title: [A model of multiple contacts, describing the interaction of rRNA sites with mRNA].
abstract: A model describing the interaction of a short oligonucleotide with long polynucleotide matrix has been developed. The model allows to calculate possibilities of oligonucleotide binding with different matrix sites on the basis of thermodynamic parameters of duplex formation. The model has been used for description of messenger RNA interaction with "clinger-fragment" sites on ribosomal RNA, which are potential sites of hybridization with mRNA. A possibility of rRNA interaction with mRNA by means of multiple duplex formation between "clinger-fragments" and numerous complementary short mRNA sites is discussed.
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Nechipurenko
authors.forename: N V
authors.initials: NV
authors.lastname: Popov
authors.forename: S A
authors.initials: SA
authors.lastname: Shabalina
authors.forename: M A
authors.initials: MA
authors.lastname: Isaev
authors.forename: O V
authors.initials: OV
authors.lastname: Matveeva
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000737:chemistry / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D012333:RNA, Messenger; D012335:RNA, Ribosomal