title: Immunoglobulin A levels in bronchial samples during mechanical ventilation and onset of nosocomial pneumonia in critically ill patients.
abstract: Local immunoglobulins play a key role in host defense against lung infection. We investigated the pattern of evolution of bronchial albumin, IgA, and IgG levels in ventilated ICU patients in relation to nosocomial pneumonia. Immunocompetent, critically ill patients underwent serial blood and bronchial protein determinations on Day 1 (intubation day), and on Days 3, 7, 10, and 14. The variations in proteins levels were compared with corresponding Day 1 values in the whole population, and between patients who developed lung infections (Group A) and the remaining population (Group B). Forty-four patients were included into the study. In the whole population, when compared with the baseline value, bronchial IgA/albumin ratio increased significantly (Day 3, +58%, p = 0.04); Day 14, +171%, p < 0.01), but serum IgA/albumin and serum and bronchial IgG/albumin ratios did not change significantly. In Group A, the increase in the IgA/albumin ratio was less than in Group B (Day 3, +15% versus +87%, p = 0.04; Day 14, +29% versus +210%, p < 0.01). No significant differences were observed between the two groups for bronchial and plasma albumin and IgG levels and for bronchial polymorphonuclear elastase levels. Bronchial IgA production was enhanced in ventilated patients. A reduction in this enhanced bronchial IgA production might account for the development of nosocomial pneumonia.
authors.affiliation: Service de Réanimation Médicale, Hôpital Raymond Poincaré, Garches, Université Paris V., France.
authors.forename: D
authors.initials: D
authors.lastname: Annane
authors.forename: B
authors.initials: B
authors.lastname: Clair
authors.forename: B
authors.initials: B
authors.lastname: Mathieu
authors.forename: C
authors.initials: C
authors.lastname: Boucly
authors.forename: O
authors.initials: O
authors.lastname: Lesieur
authors.forename: L
authors.initials: L
authors.lastname: Donetti
authors.forename: M
authors.initials: M
authors.lastname: Gatey
authors.forename: J C
authors.initials: JC
authors.lastname: Raphael
authors.forename: P
authors.initials: P
authors.lastname: Gajdos
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000276:immunology*; D003422:Critical Care; D016638:Critical Illness; D003428:Cross Infection / Q000201:enzymology / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis* / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007710:Klebsiella Infections / Q000201:enzymology / Q000276:immunology; D007711:Klebsiella pneumoniae; D019272:Leukocyte Elastase; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000032:analysis; D018410:Pneumonia, Bacterial / Q000201:enzymology / Q000276:immunology*; D011018:Pneumonia, Pneumococcal / Q000201:enzymology / Q000276:immunology; D011023:Pneumonia, Staphylococcal / Q000201:enzymology / Q000276:immunology; D011552:Pseudomonas Infections / Q000201:enzymology / Q000276:immunology; D011550:Pseudomonas aeruginosa; D012121:Respiration, Artificial; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000418:Albumins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012709:Serum Albumin; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase