title: A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation.
abstract: The X and Y chromosomes that maintain human dimorphism are thought to have descended from a single progenitor, with the Y chromosome becoming largely depleted of genes. A number of genes, however, retain copies on both X and Y chromosomes and escape the inactivation that affects most X-linked genes in somatic cells. Many of those genes are present in two pseudoautosomal regions (PARs) at the termini of the short (p) and long (q) arms of the sex chromosomes. For both PARs, pairing facilitates the exchange of information, ensuring the homogenisation of X and Y chromosomal material in these regions. We report here a strikingly different regulation of expression of a gene in Xq PAR. Unlike all Xp PAR genes studied so far, a synaptobrevin-like gene, tentatively named SYBL1, undergoes X inactivation. In addition, it is also inactive on the Y chromosome, thereby maintaining dosage compensation in an unprecedented way.
authors.affiliation: International Institute of Genetics and Biophysics, CNR, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: D'Esposito
authors.forename: A
authors.initials: A
authors.lastname: Ciccodicola
authors.forename: F
authors.initials: F
authors.lastname: Gianfrancesco
authors.forename: T
authors.initials: T
authors.lastname: Esposito
authors.forename: L
authors.initials: L
authors.lastname: Flagiello
authors.forename: R
authors.initials: R
authors.lastname: Mazzarella
authors.forename: D
authors.initials: D
authors.lastname: Schlessinger
authors.forename: M
authors.initials: M
authors.lastname: D'Urso
mesh_terms: D000595:Amino Acid Sequence; D029681:Arabidopsis Proteins; D001483:Base Sequence; D018244:Chromosomes, Artificial, Yeast; D004303:Dosage Compensation, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D050683:R-SNARE Proteins; D012260:Ribonucleases; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D029681:Arabidopsis Proteins; D008565:Membrane Proteins; D050683:R-SNARE Proteins; C099591:SAR1 protein, Arabidopsis; C121241:VAMP7 protein, human; D012260:Ribonucleases