Determination of combined residues of metalaxyl and 2,6-dimethylaniline metabolites in urine by gas chromatography/mass spectrometry.
A gas chromatographic/mass spectrometric (GC/MS) method for determination of combined residues of the fungicide metalaxyl and its metabolites in urine containing the 2,6-dimethylaniline moiety is described. The method is a modification of a method of Balasubramanian and Perez for analysis of metalaxyl in vegetables. Noted modifications include replacement of steam extraction with extraction by methylene chloride and use of electron impact ionization GC/MS in the selected-ion mode. The method is linear over the range of 0.1-5 micrograms 2,6-dimethylaniline/g urine and has a detection limit of 0.025 microgram/g.
Headley
J V
JV
Environment Canada, National Hydrology Research Institute, Saskatoon, SK, Canada.
Maxwell
D B
DB
Swyngedouw
C
C
Purdy
J R
JR
D000409:Alanine / Q000031:analogs & derivatives* / Q000652:urine; D000814:Aniline Compounds / Q000652:urine*; D005659:Fungicides, Industrial / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008752:Methylene Chloride; D010573:Pesticide Residues / Q000652:urine*
D000814:Aniline Compounds; D005659:Fungicides, Industrial; D010573:Pesticide Residues; C028175:metalaxyl; C007766:2,6-xylidine; D008752:Methylene Chloride; D000409:Alanine