title: Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas.
abstract: Serum concentrations of trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin (trypsin-2-AAT) were determined in 145 patients with malignant and 61 with benign digestive-tract diseases. The validity of these tests for detection of cancer was compared with that of CA 19-9 and CEA. Elevated levels of trypsinogen-2 (>90 micrograms/l) and trypsin-2-AAT (>25 micrograms/l) were found in 46% and 42%, respectively, of patients with malignant disease and the levels of trypsinogen-2 were significantly higher than in those with benign disease (p<0.005). High trypsinogen-2 and trypsin-2-AAT concentrations were found most often in patients with biliary and pancreatic cancer, but also in benign obstructive biliary disease. Our results suggest that trypsinogen-2 and trypsin-2-AAT are new potential markers for cholangiocarcinomas.
authors.affiliation: Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Hedström
authors.forename: C
authors.initials: C
authors.lastname: Haglund
authors.forename: R
authors.initials: R
authors.lastname: Haapiainen
authors.forename: U H
authors.initials: UH
authors.lastname: Stenman
mesh_terms: D000681:Amylases / Q000097:blood; D001650:Bile Duct Neoplasms / Q000097:blood* / Q000201:enzymology; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood; D018281:Cholangiocarcinoma / Q000097:blood* / Q000201:enzymology; D004066:Digestive System Diseases / Q000097:blood* / Q000201:enzymology; D004067:Digestive System Neoplasms / Q000097:blood* / Q000201:enzymology; D005189:False Positive Reactions; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood; D010190:Pancreatic Neoplasms / Q000097:blood; D014357:Trypsin / Q000032:analysis*; D014362:Trypsinogen / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D000515:alpha 1-Antitrypsin; C064831:PRSS2 protein, human; D014362:Trypsinogen; D000681:Amylases; D014357:Trypsin; D001663:Bilirubin