Acute exposure to carbon monoxide does not affect plasma lipids, lipoproteins, and apolipoproteins.
OBJECTIVE
To examine the effects of acute exposure to carbon monoxide and hypoxia on plasma lipids, lipoproteins, and apolipoproteins.


METHODS
Random-order assignment to blinded, inhaled exposures of carbon monoxide and hypoxia.


METHODS
Research laboratory of ambulatory subjects.


METHODS
10 elderly, male nonsmokers with chronic stable angina.


METHODS
Random-order two-hour inhaled exposure to clean air at sea level, carbon monoxide at sea level, carbon monoxide at high altitude, and clean air at high altitude.


METHODS
Fasting plasma lipids, lipoproteins, and apolipoproteins before and after exposures.


RESULTS
No differences were noted between fasting plasma lipid, lipoprotein, or apolipoprotein levels before and after exposures.


CONCLUSIONS
Acute exposure to carbon monoxide and high altitude does not affect fasting plasma lipid, lipoprotein, or apolipoprotein levels.
Leaf
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DA
Department of Medicine, School of Medicine, University of California, Los Angeles, USA.
Kleinman
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MT
D000368:Aged; D000369:Aged, 80 and over; D000531:Altitude; D000787:Angina Pectoris / Q000097:blood / Q000150:complications; D001053:Apolipoproteins / Q000097:blood*; D002248:Carbon Monoxide / Q000494:pharmacology; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000150:complications; D003327:Coronary Disease / Q000139:chemically induced; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000139:chemically induced / Q000150:complications; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D002248:Carbon Monoxide