title: Serum HGF levels in acute renal rejection after living related renal transplantation.
abstract: Hepatocyte growth factor (HGF), a long sought-after hepatotrophic factor, has recently been shown to act as a renotrophic factor in regeneration of the kidney. We investigated serum HGF levels in 16 renal transplant patients. In patients with acute rejection, the serum HGF level was markedly increased (over 1 ng/ml), and its elevation was accompanied by an increase in serum creatinine and blood urea nitrogen (BUN). In contrast, serum HGF levels were continuously low in patients without rejection. We conclude that serum HGF may become a clinically useful marker for the assessment of acute renal rejection.
authors.affiliation: Department of Urology, Osaka University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Namiki
authors.forename: S
authors.initials: S
authors.lastname: Takahara
authors.forename: K
authors.initials: K
authors.lastname: Matsumiya
authors.forename: N
authors.initials: N
authors.lastname: Kondoh
authors.forename: Y
authors.initials: Y
authors.lastname: Kokado
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000097:blood*; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D017228:Hepatocyte Growth Factor