[Sensitivity in vivo and in vitro of Plasmodium falciparum to chloroquine and amodiaquine in Bangangte (west Cameroon)].
A cross-sectional malaria survey was conducted during the rainy season in Bangangté (West-Cameroon), a town of 90,000 inhabitants located in the high tablelands zone of Cameroon. An in vivo study revealed that 50% of P. falciparum malaria patients were resistant to chloroquine (25 mg/kg over 3 days) and 26.3% to amodiaquine (35 mg/kg over 3 days) at a RII/RIII level. In addition, plasmodial indices indicated that malaria was mesoendemic in this area of Cameroon.
Agnamey
P P
PP
Laboratoire de Parasitologie, Hôpital Charles-Nicolle, CHU, Rouen, France.
Leroy
G
G
Kouamouo
J
J
Brasseur
P
P
D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D000655:Amodiaquine; D002738:Chloroquine