Effects of topical anandamides on intraocular pressure in normotensive rabbits.
A series of anandamide-type compounds were synthesized and studied for their effect on the intraocular pressure (IOP) of normotensive pigmented rabbits. Each test compound was dissolved in an aqueous 2-hydroxypropyl-beta-cyclodextrin solution and administered (31.25 - 62.5 micrograms) unilaterally to the eye. The most promising anandamides caused a statistically significant reduction of IOP in treated eyes, usually preceded by an initial transient elevation of IOP, compared to saline controls. In the contralateral untreated eyes, only a marginal or short hypotensive response was observed. Indomethacin pre-treatment (12.5 mg, s.c.) eliminated the IOP response to administered anandamides and arachidonic acid.
Pate
D W
DW
Department of Pharmaceutical Chemistry, University of Kuopio, Finland.
Järvinen
K
K
Urtti
A
A
Jarho
P
P
Fich
M
M
Mahadevan
V
V
Järvinen
T
T
D000287:Administration, Topical; D000818:Animals; D002186:Cannabinoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013329:Structure-Activity Relationship
D002186:Cannabinoids; D007213:Indomethacin