title: Sustained trilineage recovery and disappearance of abnormal chromosome clone in a patient with myelodysplastic syndrome following combination therapy with cytokines (granulocyte colony-stimulating factor and erythropoietin) and high-dose methylprednisolone.
abstract: We report a case of hypoplastic myelodyplastic syndrome (MDS) (refractory anemia (RA)) in which sustained trilineage haematological response and persistent disappearance of an abnormal chromosome clone were achieved after treatment with combination therapy of cytokines (granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Epo)) and methylprednisolone (mPSL) pulse dose. The patient's haematological recovery was rapid and maintained even after cessation of the therapy. In addition, the predominant chromosome clone 13q- in bone marrow cells disappeared in the fourth week. The patient's improved bone marrow haemopoiesis and disappearance of the abnormal chromosome has continued to the present, 13 months after treatment. The occurrence of both trilineage response and abnormal chromosome disappearance in MDS patients treated with cytokine(s) or steroids is rare. Combination therapy might therefore be advantageous in MDS.
authors.affiliation: Department of Internal Medicine, Hitachi General Hospital, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Fukuoka
authors.forename: A
authors.initials: A
authors.lastname: Nakatani
authors.forename: A
authors.initials: A
authors.lastname: Ohsaka
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002872:Chromosome Deletion; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007621:Karyotyping; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000235:genetics* / Q000628:therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; D008775:Methylprednisolone