title: Treatment of large and giant fusiform intracranial aneurysms with Guglielmi detachable coils.
abstract: Results in nine patients with large or giant fusiform intracranial aneurysms that were treated with Guglielmi detachable coils (GDCs) are reported. There were six males and three females between the ages of 12 and 63. Four patients presented with subarachnoid hemorrhage (SAH) and four with mass effect; in one patient the aneurysm was asymptomatic and located in an arterial feeder of an arteriovenous malformation. Five aneurysms were supratentorial and four were in the posterior fossa. Five were giant and four were large. Selective occlusion with preservation of the parent artery was attempted in three cases, and complete occlusion of the aneurysm and the parent artery was performed in six patients. The tolerance to parent artery occlusion was assessed by angiography, balloon test occlusion, and amytal testing. Six aneurysms were permanently occluded and two partially recanalized. In one case, GDC embolization was not possible. The four patients who presented with SAH made an excellent clinical recovery. Three of the four patients presenting with mass effect recovered completely and one remained unchanged. The patient with an incidental aneurysm remained asymptomatic. There were no permanent complications. In conclusion, GDCs were useful for the occlusion of large and giant intradural fusiform aneurysms. Occlusion of the aneurysm and the parent artery afforded the greatest opportunity for a complete cure. Advantages of GDCs compared to balloons include: occlusion of a shorter segment of normal artery, no traction on the parent vessel, and safer and easier catheterization techniques.
authors.affiliation: Department of Radiology, University of California, Los Angeles Medical Center, USA.
authors.forename: Y P
authors.initials: YP
authors.lastname: Gobin
authors.forename: F
authors.initials: F
authors.lastname: Viñuela
authors.forename: J H
authors.initials: JH
authors.lastname: Gurian
authors.forename: G
authors.initials: G
authors.lastname: Guglielmi
authors.forename: G R
authors.initials: GR
authors.lastname: Duckwiler
authors.forename: T F
authors.initials: TF
authors.lastname: Massoud
authors.forename: N A
authors.initials: NA
authors.lastname: Martin
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D002648:Child; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013345:Subarachnoid Hemorrhage / Q000209:etiology; D016896:Treatment Outcome