Double pathology in Rasmussen's encephalitis: etiologic considerations.
In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of lamination and dysplastic neurons, gliosis, microglial nodules, and perivascular cuffing. Such "double pathology" (dysgenesia and a chronic inflammatory process) may have implications for the pathophysiology of Rasmussen's syndrome.
Yacubian
E M
EM
Department of Neurology, University of Sao Paulo School of Medicine, Brazil.
Rosemberg
S
S
Marie
S K
SK
Valério
R M
RM
Jorge
C L
CL
Cukiert
A
A
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D017036:Epilepsia Partialis Continua / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed