Persistence of fetal hemoglobin production after successful transplantation of cord blood stem cells in a patient with sickle cell anemia.
A girl with sickle cell anemia was treated with cord blood transplantation combined with hematopoietic growth factor. Cord blood cells were collected from a sister with an identical human leukocyte antigen complex who was a carrier of the sickle cell trait (hemoglobin AS). The patient had complete engraftment and no graft-versus-host disease. The persistence of a high level of fetal hemoglobin 6 months after engraftment was noted.
Brichard
B
B
Department of Pediatric Hematology, University of Louvain Medical School, Brussels, Belgium.
Vermylen
C
C
Ninane
J
J
Cornu
G
G
D000755:Anemia, Sickle Cell / Q000601:surgery*; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D004586:Electrophoresis; D005260:Female; D005312:Fetal Blood; D005319:Fetal Hemoglobin / Q000378:metabolism*; D006680:HLA Antigens; D006801:Humans
D006680:HLA Antigens; D005319:Fetal Hemoglobin