title: Lung cancer, smoking, and environment: a cohort study of the Danish population.
abstract: OBJECTIVE
  The almost twofold difference in lung cancer incidence between people living in Copenhagen and in rural area of Denmark in the 1980s led to public concern; this study was undertaken to assess the effects of air pollution and occupation on lung cancer in Denmark, with control for smoking habits.
  
  
  METHODS
  Cohort study of national population.
  
  
  METHODS
  People aged 30-64 and economically active in 1970 (927,470 men and 486,130 women).
  
  
  METHODS
  Relative risks for lung cancer estimated with multiplicative Poisson modelling of incidence rates.
  
  
  RESULTS
  Differences in smoking habit explained about 60% of the excess lung cancer risk in Copenhagen for men and 90% for women. After control for smoking, workers had double the lung cancer risk of teachers and academics. There was only a small independent effect of region.
  
  
  CONCLUSIONS
  Smoking is the main factor behind the regional differences in lung cancer incidence in Denmark, and occupational risk factors also seem to have an important role. The outdoor air in Copenhagen around 1970 contained on average 50-80 micrograms/m3 of sulphur dioxide, 80-100 micrograms/m3 total suspended particulate matter, and up to 10 ng/m3 benzo(a)pyrene and had peak values of daily smoke of 120 micrograms/m3. Region had only a small effect on incidence of lung cancer int eh present study, which suggests that an influence of outdoor air pollution on lung cancer is identifiable only above this pollution level.
authors.affiliation: Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Engholm
authors.forename: F
authors.initials: F
authors.lastname: Palmgren
authors.forename: E
authors.initials: E
authors.lastname: Lynge
mesh_terms: D000328:Adult; D000397:Air Pollution / Q000009:adverse effects*; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D009790:Occupations; D012111:Residence Characteristics; D012307:Risk Factors; D012423:Rural Health; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology*; D014504:Urban Health