Polycondensed nitrogen heterocycles. Part 27. Indolo[3,2-c]cinnoline. Synthesis and antileukemic activity.
Indolo[3,2-c]cinnolines of type 5, variously substituted either in the indole and in the cinnoline moieties, were prepared in good overall yields, by intramolecular cyclization of indolo derivatives 4. Compounds 5a-d showed a good cytotoxic activity against FLC and K562 leukemic cell lines, both sensitive and multi-drug resistant.
Cirrincione
G
G
Istituto Farmacochimico, Università degli Studi, Palermo.
Almerico
A M
AM
Diana
P
P
Grimaudo
S
S
Dattolo
G
G
Aiello
E
E
Barraja
P
P
Mingoia
F
F
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds