title: Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
abstract: This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia and pretreatment measurement of tumor oxygenation. The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of <10 mm Hg (P=0.01). There were eight treatment failures; the first site of recurrence was lung in all patients. Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P=0.03). Potential mechanisms and implications for clinical trial design are discussed.
authors.affiliation: Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina, 27710, USA. brizel@radonc.duke.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Brizel
authors.forename: S P
authors.initials: SP
authors.lastname: Scully
authors.forename: J M
authors.initials: JM
authors.lastname: Harrelson
authors.forename: L J
authors.initials: LJ
authors.lastname: Layfield
authors.forename: J M
authors.initials: JM
authors.lastname: Bean
authors.forename: L R
authors.initials: LR
authors.lastname: Prosnitz
authors.forename: M W
authors.initials: MW
authors.lastname: Dewhirst
mesh_terms: D015687:Cell Hypoxia; D006801:Humans; D009362:Neoplasm Metastasis; D011237:Predictive Value of Tests; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*