title: Successful medical treatment of severely decompensated Wilson disease.
abstract: Delayed response to medical treatment sometimes leads to unnecessary liver transplantation in patients with severely decompensated Wilson disease. We report the course of five patients (mean age 13.4 years, range 11 to 15 years) with severely decompensated Wilson disease who were successfully treated medically. Prothrombin time improved after a minimum of 1 month and returned to normal within 3 months to 1 year or more.
authors.affiliation: Department of Pediatrics, Catholic University of Louvain, Cliniques St. Luc, Brussels, Belgium.
authors.forename: E E
authors.initials: EE
authors.lastname: Santos Silva
authors.forename: J
authors.initials: J
authors.lastname: Sarles
authors.forename: J P
authors.initials: JP
authors.lastname: Buts
authors.forename: E M
authors.initials: EM
authors.lastname: Sokal
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015913:Chelation Therapy; D002648:Child; D003300:Copper / Q000652:urine; D005260:Female; D006461:Hemolysis; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000628:therapy*; D006801:Humans; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*; D011517:Prothrombin Time; D013431:Sulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D017967:Zinc Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D019287:Zinc Sulfate
chemical_list: D000900:Anti-Bacterial Agents; D013431:Sulfates; D017967:Zinc Compounds; D019287:Zinc Sulfate; D003300:Copper; D010396:Penicillamine