Pathologic changes in a long-term heterotopic heart transplant survivor.
This report concerns the pathologic findings observed at autopsy in a 10-year-old heterotopic heart transplant under cyclosporine treatment. The allograft showed a diffuse multivessel atherosclerotic disease whereas in the recipient heart coronary arteries and aorta were focally affected by atherosclerosis. The proliferating cell nuclear antigen had significantly increased expression in the allograft vessels in comparison with the recipient.
Pucci
A
A
Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi, Torino.
Passarino
G
G
Marra
S
S
Papandrea
C
C
Casaccia
M
M
di Summa
M
M
Mollo
F
F
D003327:Coronary Disease / Q000150:complications / Q000276:immunology / Q000473:pathology*; D016572:Cyclosporine / Q000627:therapeutic use; D017809:Fatal Outcome; D006083:Graft Occlusion, Vascular / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006333:Heart Failure / Q000209:etiology / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016042:Transplantation, Heterotopic
D018809:Proliferating Cell Nuclear Antigen; D016572:Cyclosporine