Mismatch repair as an important source of new mutations in non-dividing cells.
This paper describes a mechanism which permits somatic cells to generate random mutations in the complete absence of cell proliferation. Knowledge of the existence of this mechanism should provide us with the basis for a better understanding of a number of important biological phenomena, and in particular may help to explain the origins of many human cancers.
MacPhee
D G
DG
School of Microbiology, La Trobe University, Melbourne, Victoria, Australia.
D002455:Cell Division; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009154:Mutation