title: Developmental immunohistochemistry of the 22 kDa peroxisomal membrane protein in the human brain.
abstract: We studied immunohistochemically the 22 kDa peroxisomal membrane protein (PMP 22). In the control brain, the immunopositive neurons for PMP 22 appeared 2-3 weeks earlier than those for peroxisomal enzymes. PMP 22-immunopositive glial cells appeared at 26-27 gestational weeks, increased with gestational age, and were rarely recognized after 1 year of age. In the patients with Zellweger syndrome, PMP 22-immunoreactivity was recognized in neurons, glias, liver and kidney cells.
authors.affiliation: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyawaki
authors.forename: O
authors.initials: O
authors.lastname: Sohma
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Takashima
mesh_terms: D000293:Adolescent; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002531:Cerebellum / Q000737:chemistry; D005314:Embryonic and Fetal Development / Q000502:physiology; D005625:Frontal Lobe / Q000737:chemistry; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007668:Kidney / Q000737:chemistry / Q000166:cytology; D008099:Liver / Q000737:chemistry / Q000166:cytology; D008565:Membrane Proteins / Q000032:analysis*; D008830:Microbodies / Q000737:chemistry*; D008970:Molecular Weight; D009457:Neuroglia / Q000737:chemistry; D009474:Neurons / Q000737:chemistry; D009928:Organ Specificity / Q000502:physiology
chemical_list: D008565:Membrane Proteins; C489785:PXMP2 protein, human