title: Long-term effects of inhaled nicotine.
abstract: Tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.
authors.affiliation: Department of Medicine, University Hospital, Tronheim, Norway.
authors.forename: H L
authors.initials: HL
authors.lastname: Waldum
authors.forename: O G
authors.initials: OG
authors.lastname: Nilsen
authors.forename: T
authors.initials: T
authors.lastname: Nilsen
authors.forename: H
authors.initials: H
authors.lastname: Rørvik
authors.forename: V
authors.initials: V
authors.lastname: Syversen
authors.forename: A K
authors.initials: AK
authors.lastname: Sanvik
authors.forename: O A
authors.initials: OA
authors.lastname: Haugen
authors.forename: S H
authors.initials: SH
authors.lastname: Torp
authors.forename: E
authors.initials: E
authors.lastname: Brenna
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced*; D002319:Cardiovascular System / Q000187:drug effects; D005260:Female; D018226:Fibroadenoma / Q000139:chemically induced; D008168:Lung / Q000187:drug effects; D008175:Lung Neoplasms / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009538:Nicotine / Q000633:toxicity*; D010911:Pituitary Neoplasms / Q000139:chemically induced; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D009538:Nicotine