High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome.
OBJECTIVE
To study the outcome in poor responders to three ampules (225 IU) of hMG per day in subsequent IVF treatment cycles in which six ampules (450 IU)of hMG per day were administered.


METHODS
Retrospective chart review.


METHODS
Academic tertiary center.


METHODS
Between January 1988 and May 1995, 126 poor response patients had a first treatment cycle on three ampules and a second cycle on six ampules of hMG per day.


METHODS
Numbers of follicles, oocytes, and embryos, and pregnancy rates.


RESULTS
On six ampules, patients had significantly more follicles and oocytes. The number of embryos did not differ significantly. The pregnancy rate on six ampules were low (3.2% pregnancies per cycle started).


CONCLUSIONS
Poor responders do not benefit from high-dose hMG stimulation; their reproduction outcome is poor.
Land
J A
JA
Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Maastricht, The Netherlands.
Yarmolinskaya
M I
MI
Dumoulin
J C
JC
Evers
J L
JL
D000328:Adult; D004622:Embryo, Mammalian; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage* / Q000627:therapeutic use*; D009865:Oocytes / Q000166:cytology; D006080:Ovarian Follicle / Q000502:physiology; D011247:Pregnancy; D012189:Retrospective Studies
D008596:Menotropins; D005640:Follicle Stimulating Hormone