Effects of aspirin on status of thrombin generation in atrial fibrillation.
Aspirin 330/mg/day suppressed platelet function in patients with atrial fibrillation, although it did not affect the increased coagulation activity in these patients. Findings support the premise that anticoagulant therapy is more appropriate than aspirin for the prevention of systemic embolism in patients with atrial fibrillation.
Yamamoto
K
K
Department of Cardiology, Jichi Medical School, Tochigi, Japan.
Ikeda
U
U
Fukazawa
H
H
Shimada
K
K
D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000097:blood* / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013917:Thrombin / Q000096:biosynthesis / Q000187:drug effects*
D013917:Thrombin; D001241:Aspirin