Gastrointestinal hemorrhage complicating aspirin therapy in acute Kawasaki disease.
Although gastrointestinal hemorrhage is a well-recognized complication of aspirin therapy, this side effect has not been previously reported in patients with Kawasaki disease (KD). We describe two children with typical KD who had massive gastrointestinal bleeding that required hospitalization and transfusion. Physicians caring for patients with KD should instruct parents on the signs and symptoms of aspirin toxicity. Fortunately, gastrointestinal hemorrhage appears to be a rare complication of salicylate therapy in patients with Kawasaki disease.
Matsubara
T
T
Department of Pediatrics, University of California-San Diego, La Jolla 92093, USA.
Mason
W
W
Kashani
I A
IA
Kligerman
M
M
Burns
J C
JC
D000208:Acute Disease; D001241:Aspirin / Q000009:adverse effects*; D002675:Child, Preschool; D002927:Cimetidine / Q000627:therapeutic use; D017707:Erythrocyte Transfusion; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D005719:gamma-Globulins / Q000627:therapeutic use
D005719:gamma-Globulins; D002927:Cimetidine; D001241:Aspirin