title: [Modifications of fractional uptake method for 123I-IMP].
abstract: We intended to improve the fractional uptake (FU) method which was developed to quantify cerebral blood flow using 123I-IMP without blood sampling. The quantification of cardiac output (CO) using first-pass data was adapted to FU method while the original FU method used CO which was estimated from the body surface area of patients. Time-radioactivity curves of the lungs and brain were separately obtained by a small-field-of-view gamma camera. In 24 cases, mean cerebral blood flow (mCBF) obtained by the modified FU method showed the better correlation (r = 0.833, P< 0.001) to mCBF measured by the Patlak plot with 99mTc-HMPAO than the original FU method (r=0.667, p<0.01). With these modifications, the reliability of FU method could be improved and the modified FU method might be performed in the other institutions.
authors.affiliation: Section of Nuclear Medicine, Noto General Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Kinuya
authors.forename: R
authors.initials: R
authors.lastname: Satake
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: J
authors.initials: J
authors.lastname: Shiozaki
authors.forename: M
authors.initials: M
authors.lastname: Takimoto
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Tonami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D002302:Cardiac Output; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine