title: Managing HIV. Part 3. Mechanisms of disease. 3.2 How HIV produces immune deficiency.
abstract: Initially, the immune system controls HIV infection, but over time the virus depletes the population of CD4+ T cells and disturbs the homoeostasis and function of other cells in the immune system. Extensive destruction of the immune system eventually leaves the body defenceless.
authors.affiliation: Department of Clinical Immunology and Allergy, Westmead Hospital, Sydney, NSW, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Ffrench
authors.forename: G J
authors.initials: GJ
authors.lastname: Stewart
authors.forename: R
authors.initials: R
authors.lastname: Penny
authors.forename: J A
authors.initials: JA
authors.lastname: Levy
mesh_terms: D015704:CD4 Antigens; D006678:HIV / Q000472:pathogenicity* / Q000502:physiology; D015658:HIV Infections / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007109:Immunity / Q000502:physiology; D008198:Lymph Nodes / Q000821:virology; D017741:Survivors; D014774:Virulence; D014779:Virus Replication
chemical_list: D015704:CD4 Antigens