title: Long-term effects of multiple pregnancies on cardiac dimensions and systolic and diastolic function.
abstract: OBJECTIVE
  This study evaluated whether the recurring volume loading and hormonal changes in multiple pregnancies might have some cumulative effect on heart size and function.
  
  
  METHODS
  Echocardiograms were performed on 20 healthy women with at least 4 (mean 5.2) term pregnancies; 20 healthy, age-matched, nulliparous women served as controls.
  
  
  RESULTS
  There were no significant differences in chamber dimension, systolic or diastolic function, valvular incompetence, or heart rate between the groups. There was a small, but significant, prolongation in deceleration time of the E wave in the multiparous women.
  
  
  CONCLUSIONS
  These findings show that the human heart is generally able to repeatedly adapt to multiple episodes of volume overload in pregnancy without lasting detrimental structural or functional changes.
authors.affiliation: Division of Cardiology, Miriam Hospital, Brown University School of Medicine, Providence, RI 02906, USA.
authors.forename: A
authors.initials: A
authors.lastname: Sadaniantz
authors.forename: L
authors.initials: L
authors.lastname: Saint Laurent
authors.forename: A F
authors.initials: AF
authors.lastname: Parisi
mesh_terms: D000328:Adult; D002306:Cardiac Volume; D003971:Diastole; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D013599:Systole