title: Further novel milbemycin antibiotics from Streptomyces sp. E225. Fermentation, isolation and structure elucidation.
abstract: Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM48641 which possesses an alpha-methoxyl substituent at C-27, and VM48642 which contains a furan ring at the terminus of the C-26 side chain. Several of these new compounds were shown to possess potent anthelmintic activity. An analysis of NMR chemical shift trends in this series of metabolites is presented.
authors.affiliation: SmithKline Beecham Animal Health, Tadworth, Surrey, England.
authors.forename: G H
authors.initials: GH
authors.lastname: Baker
authors.forename: S E
authors.initials: SE
authors.lastname: Blanchflower
authors.forename: R J
authors.initials: RJ
authors.lastname: Dorgan
authors.forename: J R
authors.initials: JR
authors.lastname: Everett
authors.forename: B R
authors.initials: BR
authors.lastname: Manger
authors.forename: C R
authors.initials: CR
authors.lastname: Reading
authors.forename: S A
authors.initials: SA
authors.lastname: Readshaw
authors.forename: P
authors.initials: P
authors.lastname: Shelley
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006189:Haemonchus / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013302:Streptomyces / Q000378:metabolism*; D014254:Trichostrongylus / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin