title: A non-peptide angiotensin II receptor antagonist: 2-butyl-6-dimethoxymethyl-5-phenyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-imidazo[5,4-b]pyridine.
abstract: The title compound, C33H33N7O2, is one of a series of imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists showing high antihypertensive activity. The biphenyltetrazole moiety assumes the same conformation as in related compounds, but its relative orientation with respect to the central fused ring is different to that in these compounds, indicating that there is considerable conformational flexibility about the methylene bridge joining the two ring systems.
authors.affiliation: Department of Chemistry, Seoul National University, Korea nswcshin@alliant.snu.ac.kr.
authors.forename: W
authors.initials: W
authors.lastname: Shin
authors.forename: T S
authors.initials: TS
authors.lastname: Yoon
authors.forename: S E
authors.initials: SE
authors.lastname: Yoo
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: C099450:2-butyl-6-dimethoxymethyl-5-phenyl-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazo(5,4-b)pyridine; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D007093:Imidazoles; D011725:Pyridines