Enhanced degradation of EGF receptors by a sorting nexin, SNX1.
The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.
Kurten
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RC
Department of Medicine, University of California, San Diego, La Jolla 92093-0650, USA.
Cadena
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DL
Gill
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GN
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D015536:Down-Regulation; D004705:Endocytosis; D004815:Epidermal Growth Factor / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D008247:Lysosomes / Q000378:metabolism*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D014162:Transfection; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D008024:Ligands; D033921:Vesicular Transport Proteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors