Photoreceptor and bipolar cell contributions to the cat electroretinogram: a kinetic model for the early part of the flash response.
The time course of the initial negative wave of the flash electroretinogram of the dark-adapted cat has been found to be critically dependent of contributions from cells of the inner retina, not only for very low-intensity flashes for which the negative scotopic threshold response is dominant but also when the stimulus is sufficiently intense for the rods themselves to contribute directly to the electroretinogram. However, if the inner-retinal responses are blocked pharmacologically or are suppressed by a steady adapting background, the initial negative wave of the remaining electroretinogram (the alpha wave) can be explained as the sum of photoreceptor and bipolar-cell components that can be modeled as described by Lamb and Pugh [J. Physiol. (London) 449, 717 (1992)] and Robson and Frishman [Vis. Neurosci. 12, 837 (1995)], respectively.
Robson
J G
JG
Physiological Laboratory, Cambridge, UK.
Frishman
L J
LJ
D000818:Animals; D002415:Cats; D007700:Kinetics; D008954:Models, Biological; D009407:Nerve Block; D010775:Photic Stimulation / Q000379:methods; D010786:Photoreceptor Cells / Q000502:physiology*; D012016:Reference Values; D012160:Retina / Q000166:cytology / Q000502:physiology*