In vitro activity of imipenem and six other beta-lactam antibiotics against aminoglycoside resistant gram-negative bacilli.
The in vitro activity of imipenem and six other beta-lactams (ampicillin, cefamandole, cefoxitin, ceftriaxone, ceftazidime, cefotaxime) against twenty Gram-negative bacilli resistant to clinically important aminoglycosides was studied. The bacterial strains showed high resistance (R) to gentamicin, tobramycin (R 100%), netilmicin (R 75%) and to the beta-lactams ampicillin (R 100%), cephamandole (R 90%) and cefoxitin (R 75%). The strains were susceptible to isepamicin (R 10%) and imipenem (R 10%) as well as susceptible to at least third generation cephalosporin. Three Pseudomonas aeruginosa strains were resistant to the majority of antibiotics, except for imipenem.
Bujdáková
H
H
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Kallová
J
J
Lausová
A
A
Kettner
M
M
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000378:metabolism; D002863:Chromogenic Compounds / Q000378:metabolism; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018154:Slovakia; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002863:Chromogenic Compounds; D013845:Thienamycins; D015378:Imipenem; C034313:pyridine-2-azo-4-dimethylaniline cephalosporin; D001618:beta-Lactamases