Cadmium mobilization by nitrogen donor chelating agents.
The relative abilities of a series of acyclic polyamine chelating agents containing only nitrogen donors (N-donors) to induce the urinary excretion of cadmium has been examined in the rat. The compounds examined include triethylenetetramine dihydrochloride (TRIEN), tris(2-aminoethyl)amine trihydrochloride (TREN), tetraethylenepentamine pentahydrochloride (TETRAEN), and pentaethylenehexamine hexahydrochloride (PENTAEN). Sodium N-methyl-D-glucamine-N-carbodithioate (NaG) was used as a positive control compound. The polyamines induced a significant increase in the urinary excretion of cadmium in rats that had been loaded with cadmium at least 4 d prior to the polyamine treatments. A comparison of these with similar data on macrocylic nitrogen donor systems, which form much more stable complexes with cadmium but are also ineffective in enhancing the excretion of cadmium from such aged deposits, suggests that the factors responsible for the relative inefficiency of these compounds may involve either a difficulty in penetrating cellular membranes or a slow rate of reaction with biologically bound cadmium. The occurrence of oliguria and anuria following the administration of the several of the polyamines indicates that their use is accompanied by significant renal damage in cadmium-exposed rats.
Jones
M M
MM
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA. JonesMM0@ctrvax.vanderbilt.edu
Xu
C
C
Singh
P K
PK
Walker
E M
EM
D000818:Animals; D002104:Cadmium / Q000633:toxicity / Q000652:urine*; D002614:Chelating Agents / Q000378:metabolism / Q000494:pharmacology*; D005029:Ethylenediamines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D009584:Nitrogen / Q000378:metabolism*; D011073:Polyamines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D013012:Sorbitol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D013113:Spin Labels; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000378:metabolism / Q000494:pharmacology; D014266:Trientine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D002614:Chelating Agents; D005029:Ethylenediamines; D011073:Polyamines; D013113:Spin Labels; D013859:Thiocarbamates; D002104:Cadmium; C099539:tris(2-aminoethyl)amine; D013012:Sorbitol; C041262:N-methyl-D-glucamine dithiocarbamate; C031122:pentaethylenehexamine; D009584:Nitrogen; D014266:Trientine; C034269:tetraethylenepentamine