title: Effects of long-distance running on serum bilirubin.
abstract: This study was undertaken to determine the effects of long-distance running on serum bilirubin fractions. Thirteen male ultramarathon runners participating in a 100-km race volunteered for the study. Venous blood samples were obtained shortly before and immediately after the race. Decreased serum haptoglobin levels (-66%) indicated the presence of hemolysis. After accounting for plasma-volume loss, significant post-race increases were found for creatine kinase (+20-fold), creatine kinase-MB (+252%), alanine aminotransferase (+42%), aspartate aminotransferase (+193%), gammaglutamyl transpeptidase (+56%), and glutamate dehydrogenase (+58%) serum activities, suggesting that running causes alterations of both muscle and liver tissues. Serum concentration of total bilirubin was significantly elevated (+106%) following the race, with changes corresponding to both unconjugated (+96%) and conjugated esters (+283%) of the pigment and significant increases in the ratio of esterified to total bilirubin. Our data show that long-distance running causes increases in the different serum bilirubin fractions which can be accounted for both hemolysis and hepatic disturbances.
authors.affiliation: Institute of Physical Education, León, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: De Paz
authors.forename: J G
authors.initials: JG
authors.lastname: Villa
authors.forename: P
authors.initials: P
authors.lastname: Lopez
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez-Gallego
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D005969:Glutamate Dehydrogenase / Q000097:blood; D006242:Haptoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007527:Isoenzymes; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D010953:Plasma Volume; D012420:Running / Q000502:physiology*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D006242:Haptoglobins; D007527:Isoenzymes; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D001663:Bilirubin