Study of lens autofluorescence by fluorophotometry in pregnant patients with diabetes.
OBJECTIVE
Lens autofluorescence originates from an accumulation of fluorescent substances such as the tryptophan-derived residues and glycosylated protein aggregations, which are associated with the process of cataractogenesis and lens aging. The purpose of this investigation is to determine whether pregnancy alters the typical constituents of the lens autofluorescence in patients with diabetes and, if so, to what degree this may occur.


METHODS
Lens autofluorescence was studied with fluorophotometry in 127 eyes of 72 individuals: 23 control subjects, 6 healthy pregnant women, 21 patients with diabetes, and 44 pregnant patients with diabetes.


RESULTS
The autofluorescence values were 311 +/- 130 ng/ml, 253 +/- 40 ng/ml, 378 +/- 110 ng/ml, and 562 +/- 164 Eq ng/ml (Eq ng/ml = Ng/ml equivalent fluorescein) in the four groups, respectively. The difference between the nonpregnant and pregnant patients with diabetes was significant (P < 0.001).


CONCLUSIONS
These results suggest that there is an important deterioration in the metabolic state of the lens during gestation in patients with diabetes, as is the case for diabetic retinopathy.
Beneyto
P
P
Department of Ophthalmology, Severo Ochoa Hospital, Madrid, Spain.
Alonso
I
I
Pérez
T M
TM
López
L
L
Fonseca
A
A
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005453:Fluorescence; D015590:Fluorophotometry / Q000379:methods; D006801:Humans; D007908:Lens, Crystalline / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000503:physiopathology*