Acute myelogenous leukemia: a disorder of gene splicing?
The two common rearrangements t(8;21) and inv(16) are found in approximately 20% of all acute myelogenous leukemias. Both aberrations result in the formation of a fusion gene, involving subunits of the core binding transcription factor (CBF). In this manuscript we hypothesize that the alternative splicing of the fusion genes, leading to truncated CBF subunits, contributes to the pathogenesis of t(8;21) and inv(16) leukemias.
van der Reijden
B A
BA
Department of Human Genetics, Sylvius Laboratories, Leiden University, The Netherlands.
van Ommen
G J
GJ
Hagemeijer
A
A
Breuning
M H
MH
D017398:Alternative Splicing; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic