title: Assessment of radioactive systemic uptakes by deconvolution of individual monitoring results.
abstract: The methods of interpretation presently available for evaluating individual radioactivity intakes from measured data involve difficulties connected with the adaptation of metabolic models to the situations encountered in practice. These difficulties essentially concern the definition of appropriate parameters for each encountered case, and very often- except for characterized incidents-erroneous appreciation of the time course of contamination episodes and of th routes of entry. These considerations led us to develop a simplified method of interpreting monitoring data, by considering separately the data relating to routes of entry and those concerning systemic contamination, i.e., the contamination occurring after the transfer of radionuclides to the blood. An approach to interpreting measurements of systemic contamination is proposed in this study. This method is to calculate, from these measurements, the values for the activity absorbed daily from the routes of entry into the blood using the appropriate retention and excretion functions. a day-to-day follow-up of the absorbed activity becomes possible, thus enabling its real-time evolution to be recorded and easy to consult. A few applications of the method are described, including cases of acute tritium and uranium contamination and of chronic contamination by tritium, uranium, and iodine. The conditions and constraints required to validate the proposed approach are indicated.
authors.affiliation: Commissariat à l'Energie Atomique, Institut de Protection et de Sureté Nucléaire, Centre d'Etudes de Fontenay-aux-roses, Fontenay-Aux-Roses, France.
authors.forename: J
authors.initials: J
authors.lastname: Piechowski
authors.forename: B
authors.initials: B
authors.lastname: Menoux
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D016273:Occupational Exposure; D011829:Radiation Dosage; D011834:Radiation Monitoring; D011868:Radioisotopes / Q000493:pharmacokinetics*; D014316:Tritium / Q000493:pharmacokinetics; D014501:Uranium / Q000493:pharmacokinetics
chemical_list: D011868:Radioisotopes; D014316:Tritium; D014501:Uranium