[Influence of treatment using recombinant tumor necrosis factor alpha (hrec TNF alpha) on circadian rhythm of cortisol secretion in patients with advanced neoplastic disease].
Tumor Necrosis Factor alpha is one of cytokines administered in immunotherapy of advanced neoplastic disease. Its action is exerted through immune endocrine and central nervous systems. The purpose of this study was to assess the influence of hrec TNF alpha administration in patients with advanced neoplasms on the level of cortisol in serum and its circadian rhythm. Serum cortisol was determined several times a day before and just after hrec TNF alpha first immunotherapeutic cycle. The results of the investigation were analysed with the Cosinor test. Serum concentration of hormone was determined using radioimmunoassay method. The results of this study showed the decreasing influence of hrec TNF alpha administration on cortisol secretion by adrenals with no disturbances in that circadian rhythm.


CONCLUSIONS
It might be possible that some side effects of hrec TNF alpha administration are connected with the decreasing cortisol level.
Zubelewicz
B
B
Katedra i Klinika Chorób Wewnetrznych Slaskiej Akademii Medycznej w Bytomiu.
Braczkowski
R
R
Romanowski
W
W
Grzeszczak
W
W
D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D011863:Radioimmunoassay; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D006854:Hydrocortisone