title: Hyperprolactinemia in systemic lupus erythematosus?
abstract: The objective of this project was to determine the prevalence of hyperprolactinemia (HPRL) in systemic lupus erythematosus (SLE) and to evaluate the role of prolactin (PRL) as a disease-activity marker. We determined PRL in a cohort of 182 patients with SLE. Basal prolactin levels and clinical data (disease-activity index, sero-activity, medications) were analyzed in all patients. The findings show only mildly elevated PRL levels in four SLE-patients and normaprolactinemia in 98% (n = 178), without any association with disease activity. Our results differ from previous studies. HPRL appears not to be prevalent in SLE, nor to be associated with disease activity.
authors.affiliation: Center of Rheumatology, Heinrich-Heine-University of Düsseldorf, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Ostendorf
authors.forename: R
authors.initials: R
authors.lastname: Fischer
authors.forename: R
authors.initials: R
authors.lastname: Santen
authors.forename: B
authors.initials: B
authors.lastname: Schmitz-Linneweber
authors.forename: C
authors.initials: C
authors.lastname: Specker
authors.forename: M
authors.initials: M
authors.lastname: Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011388:Prolactin / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D011388:Prolactin