Memory tests distinguish between patients with focal temporal and extratemporal lobe epilepsy.
We examined the ability of preoperative memory performance to distinguish between patients who had been diagnosed as having left (LTLE, n = 31), right (RTLE, n = 37), and extra-(ETLE, n = 17) temporal lobe focal epilepsy. All patients eventually underwent surgical resections. Analyses indicated that the ETLE group performed better than the RTLE group on nonverbal memory measures and better than the LTLE group on verbal memory measures. Discriminant function analyses indicated that use of a combination of measures that assess different aspects of memory were of significant value in distinguishing between patients with focal TLE and ETLE. This approach, as compared the use of single measures, improved classification rates of all three groups. The best single predictor of group membership, an index of verbal learning, yielded a 47% overall correct classification rate, with sensitivities ranging from 25 to 59%, and performed at worse than chance levels in classifying RTLE patients. A multivariate approach, which included an index of verbal and nonverbal learning, incidental nonverbal memory, and consolidation of organized and rote verbal material, yielded a 65% correct classification rate, with sensitivities ranging from 57 to 75%. This compares favorably with the other noninvasive techniques for lateralizing epileptogenic lesions.
Breier
J I
JI
Department of Neurosurgery, University of Texas Health Center, Houston 77030, USA.
Plenger
P M
PM
Wheless
J W
JW
Thomas
A B
AB
Brookshire
B L
BL
Curtis
V L
VL
Papanicolaou
A
A
Willmore
L J
LJ
Clifton
G L
GL
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000601:surgery; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000601:surgery; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D012680:Sensitivity and Specificity; D013702:Temporal Lobe / Q000601:surgery; D014706:Verbal Learning; D014888:Wechsler Scales