title: Epilepsy surgery in the setting of periventricular leukomalacia and focal cortical dysplasia.
abstract: We report an infant who had successful epilepsy surgery for intractable infantile spasms in the setting of bilateral periventricular leukomalacia and remote germinal matrix hemorrhage. Although MRI gave evidence of a diffuse cerebral insult and EEG showed hypsarrhythmia, focal epileptogenicity was suggested by previous partial seizures with onset over the right temporoparietal-occipital region and PET hypometabolism in that same area. Right temporoparietal and lateral occipital resection at 15 months resulted in seizure freedom and dramatic developmental progress at 1-year follow-up. Histopathologic examination of resected tissue showed cortical dysplasia, possibly due to the same insult that also resulted in the bilateral periventricular leukomalacia. From an etiologic perspective, this is one of very few reported cases strongly implicating acquired focal cortical dysplasia in response to a prenatal insult. From a clinical perspective, the case illustrates that the spectrum of potential surgical candidacy in infants may be broader than usually suspected.
authors.affiliation: Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: E
authors.initials: E
authors.lastname: Wyllie
authors.forename: Y
authors.initials: Y
authors.lastname: Comair
authors.forename: P
authors.initials: P
authors.lastname: Ruggieri
authors.forename: S
authors.initials: S
authors.lastname: Raja
authors.forename: R
authors.initials: R
authors.lastname: Prayson
mesh_terms: D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000002:abnormalities*; D002543:Cerebral Hemorrhage / Q000150:complications; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000150:complications*; D008279:Magnetic Resonance Imaging; D014055:Tomography, Emission-Computed