title: Development of a microporous compliant small bore vascular graft.
abstract: OBJECTIVE
  To produce biodurable small diameter microporous vascular grafts with self-sealing properties for vascular access, for peripheral vascular and potentially for coronary artery bypass. The prosthesis should retain compliance and pulsatile flow in situ using a unique modus operandi permitting wall compression which accommodates changes in volume.
  
  
  METHODS
  We have utilized efficient low temperature coagulation technology to develop a unique range of small diameter microporous vascular grafts using ChronoFlex, a biodurable polycarbonate urethane.
  
  
  RESULTS
  Grafts have been subjected to a range of in vitro and in vivo testing, demonstrating excellent physical and mechanical characteristics, self-sealing, maintenance of compliance and pulsatile flow in situ and patency up to twenty-two weeks.
authors.affiliation: PolyGraft, Inc., Tarvin, Cheshire, UK.
authors.forename: A
authors.initials: A
authors.lastname: Edwards
authors.forename: R J
authors.initials: RJ
authors.lastname: Carson
authors.forename: S
authors.initials: S
authors.lastname: Bowald
authors.forename: W C
authors.initials: WC
authors.lastname: Quist
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D002339:Carotid Arteries / Q000033:anatomy & histology; D003187:Compliance; D004285:Dogs; D005069:Evaluation Studies as Topic; D011140:Polyurethanes; D016062:Porosity; D011474:Prosthesis Design / Q000592:standards / Q000706:statistics & numerical data; D011786:Quality Control; D013997:Time Factors
chemical_list: D011140:Polyurethanes