title: der(16)t(1;16)(q21;q13) as a secondary change in alveolar rhabdomyosarcoma. A case report and review of the literature.
abstract: Alveolar rhabdomyosarcoma is an aggressive childhood tumor that exhibits muscle cell differentiation. Cytogenetically, it is characterized by t(2;13)(q35;q14); no consistent secondary abnormalities have been reported. Cytogenetic analysis of bone marrow in a case of alveolar rhabdomyosarcoma revealed t(2;13)(q35;q14) and der(16)t(1;16)(q21;q13). The present case and a review of the literature suggest that up to 11% of these tumors possess der(16)t(1;16)(q21;q13). This is similar to the incidence observed in the Ewing family of tumors, where unbalanced der(16)t(1;16) translocations, resulting in partial trisomy of 1q, are regarded as a consistent secondary cytogenetic change.
authors.affiliation: Section of Pediatrics, Institute of Cancer Research, Sutton, Surrey, U.K.
authors.forename: A P
authors.initials: AP
authors.lastname: McManus
authors.forename: T
authors.initials: T
authors.lastname: Min
authors.forename: G J
authors.initials: GJ
authors.lastname: Swansbury
authors.forename: B A
authors.initials: BA
authors.lastname: Gusterson
authors.forename: C R
authors.initials: CR
authors.lastname: Pinkerton
authors.forename: J M
authors.initials: JM
authors.lastname: Shipley
mesh_terms: D002648:Child; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D007621:Karyotyping; D008297:Male; D018232:Rhabdomyosarcoma, Alveolar / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic