title: GABAC receptors.
abstract: gamma-Aminobutyric acid (GABA) is an important neurotransmitter that mediates inhibition in the vertebrate CNS. Until recently, two receptor subtypes were known: bicuculline-sensitive GABAA and baclofen-sensitive GABAB receptors. Several lines of evidence now indicate the existence of a third class of GABA receptor, which is distinct pharmacologically from GABAA and GABAB receptors and is found predominantly in the vertebrate retina. These novel GABAC receptors are Cl- pores. They are insensitive to drugs that modulate GABAA and GABAB receptors and are activated selectively by cis-4-aminoacrotonic acid.
authors.affiliation: Max-Planck-Institut für Hirnforschung, Frankfurt, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Bormann
authors.forename: A
authors.initials: A
authors.lastname: Feigenspan
mesh_terms: D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology*
chemical_list: C087200:GABA-C receptor; D018079:Receptors, GABA