Prevention of 20-methylcholanthrene-induced sarcoma by a mistletoe extract, Iscador.
Iscador, an extract from the semi-parasitic plant Viscum album, was found to inhibit 20-methylcholanthrene-induced carcinogenesis in mice. Intraperitoneal administration of Iscador (1 mg/dose) twice weekly for 15 weeks could completely inhibit 20-methylcholanthrene-induced sarcoma in mice and protect these animals from tumour-induced death. Iscador was found to be effective even at lowered doses. After administration of 0.166, 0.0166 and 0.00166 mg/dose 67, 50 and 17% of animals respectively did not develop sarcoma.
Kuttan
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Amala Cancer Research Centre, Kerala, India.
Menon
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Kuttan
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D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D010940:Plant Proteins; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000517:prevention & control*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D010940:Plant Proteins; D008748:Methylcholanthrene; C077177:viscum album peptide