title: [Interleukin-8 in sputum from patients with pulmonary emphysema].
abstract: We measured concentrations of interleukin-8 (IL-8) in sputum from 38 patients with pulmonary emphysema, from 30 patients with bronchial asthma, and in induced sputum from 10 healthy subjects. Concentrations of IL-8 were significantly higher in sputum from patients with emphysema than in sputum from patients with asthma (mean +/- SE: 22,961 +/- 1,412 pg/ml and 9,135 +/- 1,590 pg/ml, respectively, p<0.0001) and were also higher than in sputum from healthy subjects (3,253+/-687 pg/ml, p<0.0001). Concentrations of IL-8 in sputum from patients with emphysema were unrelated to whether the patient was a current smoker or an ex-smoker, and did not correlate with concentrations of IL-8 in serum. Concentrations of IL-8 in sputum from patients with emphysema correlated significantly with FEV1% (r=-0.78, p<0.0001) and with %RV/TLC (r=0.63, p<0.01). These data suggest that IL-8 is mainly involved in chronic airway inflammation and that concentrations of IL-8 in sputum are closely related to airflow obstruction in patients with pulmonary emphysema.
authors.affiliation: Second Department of Internal Medicine, Nara Medical University, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Yoneda
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: A
authors.initials: A
authors.lastname: Fu
authors.forename: T
authors.initials: T
authors.lastname: Tokuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Nakaya
authors.forename: K
authors.initials: K
authors.lastname: Tsukaguchi
authors.forename: M
authors.initials: M
authors.lastname: Kunimatsu
authors.forename: N
authors.initials: N
authors.lastname: Narita
mesh_terms: D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000276:immunology*; D013183:Sputum / Q000276:immunology*
chemical_list: D016209:Interleukin-8