[On vitamin B1 metabolism in avitaminosis and its correction with thiamine and taurine].
The levels of phosphate esters and the activities of thiamine biotransformation enzymes in the blood and tissues of albino rats were studied during oxythiamine-induced B1 deficiency and after metabolic correction with thiamine and taurine. Among thiamine phosphates, the most informative indicators of thiamine deficiency were shown to be triphosphate esters and free thiamine diphosphate. The biosynthetic enzymes thiamine kinase and thiamine diphosphate kinase played a decisive role in maintaining the initial rate and in recovering the physiologically active forms of vitamin B1. The activation of hydrolytic enzymes of thiamine phosphate esters occurred by producing abundant free thiamine diphosphate and thiamine triphosphate. Within the first hours, taurine favoured the acceleration of phosphoester biosynthesis and, accumulating in the tissues, inhibited vitamin phosphorylation reactions.
Chernikevich
I P
IP
Gritsenko
E A
EA
Lisitskaia
I M
IM
Luchko
T A
TA
D000818:Animals; D001711:Biotransformation; D004789:Enzyme Activation; D008297:Male; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000097:blood / Q000378:metabolism; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000627:therapeutic use*; D013831:Thiamine / Q000378:metabolism* / Q000627:therapeutic use*; D013832:Thiamine Deficiency / Q000188:drug therapy / Q000378:metabolism*
D013654:Taurine; D017853:Phosphotransferases (Alcohol Group Acceptor); C035182:thiamin kinase; D017856:Phosphotransferases (Phosphate Group Acceptor); C022733:thiamin-diphosphate kinase; D013831:Thiamine