title: Ocular dominance plasticity under metabotropic glutamate receptor blockade.
abstract: Occluding vision through one eye during a critical period in early life nearly abolishes responses to that eye in visual cortex. This phenomenon is mimicked by long-term depression of synaptic transmission in vitro, which may require metabotropic glutamate receptors (mGluRs) and is age-dependent. Peaks in mGluR expression and glutamate-stimulated phosphoinositide turnover during visual cortical development have been proposed as biochemical bases for the critical period. Pharmacological blockade of mGluRs specifically prevented synapse weakening in mouse visual cortical slices but did not alter kitten ocular dominance plasticity in vivo. Thus, a heightened mGluR response does not account for the critical period in development.
authors.affiliation: Neuroscience Graduate Program, W. M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, 94143-0444, USA.
authors.forename: T K
authors.initials: TK
authors.lastname: Hensch
authors.forename: M P
authors.initials: MP
authors.lastname: Stryker
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D002415:Cats; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000502:physiology*; D012683:Sensory Deprivation; D015349:Vision, Monocular; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*; D014795:Visual Pathways
chemical_list: D001565:Benzoates; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; C079694:alpha-methyl-4-carboxyphenylglycine; D005998:Glycine