Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.
Olofsson
B
B
Ludwig Institute for Cancer Research, Stockholm, Sweden.
Pajusola
K
K
Kaipainen
A
A
von Euler
G
G
Joukov
V
V
Saksela
O
O
Orpana
A
A
Pettersson
R F
RF
Alitalo
K
K
Eriksson
U
U
D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D016228:Endothelial Growth Factors / Q000235:genetics / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D042561:Vascular Endothelial Growth Factor B
D016228:Endothelial Growth Factors; D010455:Peptides; D012333:RNA, Messenger; D042561:Vascular Endothelial Growth Factor B