[Droxicam-induced toxic hepatitis].
We present four cases of hepatitis with clinical features indicating a direct link with Droxicam. In all the cases, the presentation was that of acute hepatitis with subsequent resolution, whereas one patient developed autoimmune chronic active hepatitis. A full evaluation including ultrasound, liver biopsy, and serologic markers supported the diagnosis. Due to the fact that the "Dirección General de Farmacia y Productos Sanitarios" has approved the postponement of dispensation of products with Droxicam from February 25, 1995, this drug should not be considered anymore in the future as a potential cause of liver injury (acute or chronic hepatitis).
Berenguer
M
M
Servicio de Medicina Digestivo, Hospital La Fe, Valencia.
Pérez-Aguilar
F
F
Gisbert
C
C
Ferreres
L A
LA
Vera-Sempere
F J
FJ
Berenguer
J
J
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011725:Pyridines; C049073:droxicam