title: Uncertainty and variation in indirect exposure assessments: an analysis of exposure to tetrachlorodibenzo-p-dioxin from a beef consumption pathway.
abstract: Indirect exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other toxic materials released in incinerator emissions have been identified as a significant concern for human health. As a result, regulatory agencies and researchers have developed specific approaches for evaluating exposures from indirect pathways. This paper presents a quantitative assessment of the effect of uncertainty and variation in exposure parameters on the resulting estimates of TCDD dose rates received by individuals indirectly exposed to incinerator emissions through the consumption of home-grown beef. The assessment uses a nested Monte Carlo model that separately characterizes uncertainty and variation in dose rate estimates. Uncertainty resulting from limited data on the fate and transport of TCDD are evaluated, and variations in estimated dose rates in the exposed population that result from location-specific parameters and individuals' behaviors are characterized. The analysis indicates that lifetime average daily dose rates for individuals living within 10 km of a hypothetical incinerator range over three orders of magnitude. In contrast, the uncertainty in the dose rate distribution appears to vary by less than one order of magnitude, based on the sources of uncertainty included in this analysis. Current guidance for predicting exposures from indirect exposure pathways was found to overestimate the intakes for typical and high-end individuals.
authors.affiliation: ChemRisk, A Division of McLaren/Hart, Portland, Maine 04102, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Price
authors.forename: S H
authors.initials: SH
authors.lastname: Su
authors.forename: J R
authors.initials: JR
authors.lastname: Harrington
authors.forename: R E
authors.initials: RE
authors.lastname: Keenan
mesh_terms: D000393:Air Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002417:Cattle; D004781:Environmental Exposure; D005506:Food Contamination; D006256:Hazardous Waste; D006801:Humans; D017745:Incineration; D008460:Meat / Q000032:analysis / Q000633:toxicity*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D018570:Risk Assessment
chemical_list: D000393:Air Pollutants; D006256:Hazardous Waste; D000072317:Polychlorinated Dibenzodioxins