Translocation (1;5)(q32;q35) in CD30+ anaplastic large cell non-Hodgkin lymphona of childhood. A case report.
The authors studied cytogenetically a case of CD30+ anaplastic large cell non-Hodgkin lymphoma previously diagnosed as malignant histiocytosis and detected a translocation involving chromosomes 1 and 5, t(1;5)(q32:q35). After comparing their findings with those from reports in the literature, they comment about the importance of breakpoint q35 on chromosome 5 and point out the importance of associating morphologic, immunoperoxidase, and cytogenetic findings to confirm the diagnosis of this tumor.
Tone
L G
LG
Department of Pediatrics, School of Medicine of Riberão Preto, University of São Paulo, Brazil.
Defavery
R
R
Scrideli
C A
CA
Bernardes
J E
JE
Torres
F M
FM
Soares
F A
FA
Peres
L C
LC
Duarte
M H
MH
D002873:Chromosome Fragility; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007223:Infant; D007621:Karyotyping; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic