Expression of bcl-2 in uveal malignant melanoma.
OBJECTIVE
To evaluate the expression of the bcl-2 proto-oncogene in uveal malignant melanomas.


METHODS
We studied 20 uveal malignant melanomas (19 choroidal and 1 ciliary body) by immunohistochemistry with the bcl-2 oncoprotein monoclonal antibody and the cell proliferation marker, MIB-1.


RESULTS
Expression of bcl-2 was found in 100% of cases and was not correlated with the histologic subtype of melanoma or the MIB-1 proliferative index. Normal choroidal melanocytes were negative for bcl-2.


CONCLUSIONS
Our results suggest that altered expression of bcl-2 is common in uveal melanomas and is not related to histologic grade.
Jay
V
V
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Yi
Q
Q
Hunter
W S
WS
Zielenska
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D014604:Uveal Neoplasms / Q000235:genetics* / Q000473:pathology*