Alveolar stem cells in canine bronchial carcinogenesis.
Alveolar type II cells are not present in normal epithelium of canine segmental bronchi but after carcinogen exposure they do occur in intra-epithelial lesions with all degrees of atypia and in invasive lesions with different glandular growth patterns. Immunohistochemistry for proliferation markers (PCNA; Ki-67) strongly suggest that such novel type II cells are pluripotential stem cells in canine bronchial carcinogenesis. Very likely, bronchial carcinogenesis is subject to an oncofetal mechanism of differentiation: bronchial epithelial retrodifferentiation followed by novel differentiation of alveolar tumor stem cells.
Ten Have-Opbroek
A A
AA
Department of Pneumology, Leiden University, The Netherlands. have@rullf2.leidenuniv.nl
Benfield
J R
JR
Hammond
W G
WG
Dijkman
J H
JH
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D001984:Bronchial Neoplasms / Q000139:chemically induced / Q000737:chemistry / Q000473:pathology*; D004285:Dogs; D004848:Epithelium / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D019394:Ki-67 Antigen; D008748:Methylcholanthrene; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D009687:Nuclear Proteins / Q000032:analysis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011510:Proteolipids / Q000032:analysis; D011650:Pulmonary Alveoli / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000032:analysis
D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D011510:Proteolipids; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D008748:Methylcholanthrene