[Long term results of treatment with cytostatic drugs on respiratory function tests in children].
In 47 children after a 5 year remission of treated acute lymphoblastic leukemia respiratory function was assessed. In 11 a decrease of VC was found, while in 12 signs of obturation of lower airways were present. These results imply the presence of restrictive changes suggesting an interstitial lung disease. These children are at risk of developing a chronic pneumopathy.
Koehler
M
M
Kliniki Pediatrii i Hematologii Slaskiej AM, Zabrzu.
Brewczyński
P
P
Bubała
H
H
Białkowski
J
J
Bogusz
J
J
Wieczorek
M
M
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012074:Remission Induction; D015656:Respiratory Mechanics / Q000187:drug effects*; D014109:Total Lung Capacity / Q000187:drug effects
D000970:Antineoplastic Agents