title: Differential expression of cerbB3 in naevi and malignant melanomas.
abstract: 28 naevi, 43 malignant melanomas and 16 lymph nodes with melanoma metastases were stained immunohistochemically for the expression of cerbB3 oncoprotein. using antibody RTJ1. Positive reaction was found in 60% of naevi and in 25% of melanoma cases. The difference in frequency of the reaction occurrence between naevi and melanomas was statistically highly significant (p = 0.0017). In naevi, the percentage of cerbB3 positive cells (56.5%) was also significantly higher (p = 0.021) as compared with that of melanomas (37%). The cerbB3 positive cells were found only in cases without metastases. Positive reaction was also observed in 4 out of 16 investigated lymph nodes with melanoma metastases. The role of cerbB in the development of melanoma is discussed.
authors.affiliation: Department of Pathology, Georg August University Göttingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Korabiowska
authors.forename: J
authors.initials: J
authors.lastname: Mirecka
authors.forename: U
authors.initials: U
authors.lastname: Brinck
authors.forename: K
authors.initials: K
authors.lastname: Hoefer
authors.forename: D
authors.initials: D
authors.lastname: Marx
authors.forename: A
authors.initials: A
authors.lastname: Schauer
mesh_terms: D000911:Antibodies, Monoclonal; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D009506:Nevus / Q000378:metabolism* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D020893:Receptor, ErbB-3; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary
chemical_list: D000911:Antibodies, Monoclonal; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D020893:Receptor, ErbB-3