[Quality control of surgery in multicenter study--interinstitutional and individual differences].
In a prospective randomized controlled trial (PRCT) of adjuvant chemotherapy for gastric cancer patients participated by 6 cancer center hospitals, inter-institutional and inter-individual differences about several factors related to the surgery and remote survivals were analyzed. From 1988 to 1992, 1,049 evaluable patients were enrolled and stratified to 6 groups according to the grade of the serosal invasion and curability, and analyzed statistically.


RESULTS
1) There were no inter-institutional differences about postoperative survival rate, but there were slight differences about patient's background factors and entry policy of each institution. 2) There were no inter-institutional differences about several factors related to the surgery such as operative time, bleeding volume during operation, and the length of the administration periods. 3) There were no inter-individual differences about the length of the administration periods, but there were a little differences about operative time and the volume of hemorrhage. When the PRCT of adjuvant chemotherapy of which the end point is survival would be designed, no inter-institutional differences about remote survival and surgical operation in each institution should be confirmed before starting the trial.
Nashimoto
A
A
Division of Surgery, Niigata Cancer Center Hospital, Japan.
Nakajima
T
T
Kito
T
T
Kitamura
M
M
Okabayashi
K
K
Furukawa
H
H
Sasaki
J
J
Ohta
K
K
Yamamura
Y
Y
Nakazato
H
H
Arai
K
K
Iwanaga
T
T
Hiratuka
M
M
D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D007564:Japan; D011446:Prospective Studies; D011786:Quality Control; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate