title: [Prognostic value of lactate determination in cerebral malaria in the Cameroonian child].
abstract: In this study, we investigated the disturbances of glucose metabolism in 61 Cameroonian children aged 1 to 15 years old, infected with cerebral malaria and severe malaria cases admitted in hospitals in Yaoundé. Parasitaemia in the two groups was respectively 8.10 +/- 0.35% in cerebral malaria group and 4.47 +/- 0.84% in those admitted for severe malaria. The majority of our patients (n = 42) had normal glycaemia, while 15 cases were hyperglycemic and only 4 subjects all belonging to the cerebral malaria group were hypoglycemic. No case of hyperinsulinaemia was recorded. The level of lactate was higher in 74% of patients (19 over 26) admitted for cerebral malaria virsus 37% patients (13 over 35) admitted for severe cases. We found a positive correlation between the level of parasite and that of lactate (P < 0.01 r = 0.47). Whereas no positive correlation was found in one hand between the level of parasite and glycaemia, the level of parasites and insulin, and in the other hand between glycaemia and the level of lactate, glycaemia and insulin.
authors.affiliation: Service de Biochimie, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé, Cameroun.
authors.forename: G
authors.initials: G
authors.lastname: Lando
authors.forename: R
authors.initials: R
authors.lastname: Djiogue
authors.forename: S
authors.initials: S
authors.lastname: Djoumessi
mesh_terms: D000293:Adolescent; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D016779:Malaria, Cerebral / Q000097:blood* / Q000469:parasitology; D016778:Malaria, Falciparum / Q000097:blood / Q000469:parasitology; D008297:Male; D011379:Prognosis
chemical_list: D007328:Insulin; D007773:Lactates; D019344:Lactic Acid