title: Interleukin-10 is associated with the development of sepsis in trauma patients.
abstract: Interleukin-10 (IL-10) is a potent regulator of proinflammatory cytokines, including tumor necrosis factor-alpha, IL-1, IL-6, and interferon-gamma. We retrospectively evaluated 66 severely injured patients for detectable plasma IL-10. the presence or absence of IL-10 was correlated with clinical parameters. Forty of 66 patients had detectable levels of IL-10. Plasma IL-10 was associated with admission hypotension (p < 0.01) and the development of sepsis (p < 0.05). There was no difference between IL-10-positive and -negative patients with respect to age, mechanism or severity of injury, blood transfusion, operative interventions, or the subsequent development of ARDS, hepatic dysfunction, or renal insufficiency. We conclude that IL-10 can be detected in the plasma of some severely injured patients and that it is associated with the development of sepsis. Further investigation of the immunoregulatory effects of IL-10 after trauma is indicated.
authors.affiliation: Department of Surgery, Medical College of Georgia, Augusta 30912, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Sherry
authors.forename: J I
authors.initials: JI
authors.lastname: Cue
authors.forename: J K
authors.initials: JK
authors.lastname: Goddard
authors.forename: J B
authors.initials: JB
authors.lastname: Parramore
authors.forename: J T
authors.initials: JT
authors.lastname: DiPiro
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D016753:Interleukin-10