Coexistence of two antisynthetases in a patient with the antisynthetase syndrome.
We describe the immunologic findings in a patient with the antisynthetase syndrome characterized by prominent arthritis, lung fibrosis, and subclinical myositis. At disease onset and during the followup, this patient's serum showed 2 different subsets of antisynthetase autoantibodies: anti-Jo-1, which reacted with histidyl-transfer RNA (tRNA) synthetase by immunoblot and inhibited its enzymatic function; and anti-0J, which immunoprecipitated the multi-enzyme complex of synthetases, and reacted with lysyl-tRNA synthetase by immunoblot. This is the first report of anti-Jo-1 and another antisynthetase antibody being found together in the same patient.
Gelpí
C
C
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Kanterewicz
E
E
Gratacos
J
J
Targoff
I N
IN
Rodríguez-Sánchez
J L
JL
D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001168:Arthritis / Q000097:blood / Q000276:immunology*; D006801:Humans; D008025:Ligases / Q000276:immunology*; D008297:Male; D009220:Myositis / Q000097:blood / Q000276:immunology*; D011658:Pulmonary Fibrosis / Q000097:blood / Q000276:immunology*; D013577:Syndrome
D000888:Antibodies, Anti-Idiotypic; D008025:Ligases