The varying evolution of Friedreich's ataxia cardiomyopathy.
During a mean follow-up period of 8 years, 17% of 66 patients with Friedreich's ataxia developed hypokinetic-dilated cardiomyopathy; most patients originally had a hypertrophic left ventricle. The presence of pathologic Q waves identifies a subgroup of patients with wall motion abnormalities; these patients are more likely to develop a hypokinetic left ventricle, and the prognosis is ostensibly poorer.
Casazza
F
F
Division of Cardiology, San Carlo Hospital, Milan, Italy.
Morpurgo
M
M
D000293:Adolescent; D000328:Adult; D009202:Cardiomyopathies / Q000150:complications* / Q000000981:diagnostic imaging; D002648:Child; D018450:Disease Progression; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D005621:Friedreich Ataxia / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000209:etiology