title: Amikacin administration in open heart surgery.
abstract: Amikacin is usually administered to the patients during open heart surgery immediately after cardiopulmonary bypass (CPB) because the serum levels of this drug may decrease due to the volume overload and hemodilution caused by intravenously administered fluids (1.2-2 liters prime solution). We investigated whether this application of amikacin is necessary immediately after CPB. A total of ten patients from Dokuz Eylül University Hospital, Department of Thoracic and Cardiovascular Surgery, who were scheduled for open heart surgery were studied. Serum sodium, potassium, blood urea nitrogen and creatinine values of the patients were found to be within normal limits before the operation. Amikacin was administered to patients just before open heart surgery and 2 ml blood samples were collected from all patients 15 minutes after the drug administration, just before cardiopulmonary by-pass (CPB), at the 30th and 60th minutes of the CPB, after CPB and after the cessation of operation, 4 hours after drug administration. A significant decrease was observed between the values of 10 patients by ANOVA (p < 0.05). Serum amikacin values were found to be 9.80 +/- 0.96 micrograms/ml at the end of the operation, 4 hours after the drug administration. Since serum amikacin levels do not fall below the trough concentrations at the end of the fourth hour we conclude that it is unnecessary to repeat the dose at the end of the operation.
authors.affiliation: Dokuz Eylül University Hospital, Department of Pharmacology, Inciralti, Izmir, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Oto
authors.forename: Y
authors.initials: Y
authors.lastname: Tunçok
authors.forename: S
authors.initials: S
authors.lastname: Apaydin
authors.forename: U
authors.initials: U
authors.lastname: Açikel
authors.forename: H
authors.initials: H
authors.lastname: Güven
mesh_terms: D000328:Adult; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage* / Q000097:blood; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin