title: Varieties of progressive non-fluent aphasia.
abstract: We report four patients with progressive aphasia of the non-fluent type as the presenting clinical manifestation. The patients were included in a longitudinal study of focal progressive neuropsychological syndromes, and were periodically submitted to neuropsychological evaluations and neuroimaging studies (TC, MRI, SPET or PET). The pattern of neuropsychological impairment was in good agreement with the results of functional imaging studies, which indicated involvement of the anterior regions of the left hemisphere. The evolution of the clinical picture was extremely heterogeneous in the four patients, ranging from a relatively stable picture of transcortical motor aphasia to a severe progressive frontal lobe syndrome. Progressive non-fluent aphasia appears to be a reliable clinical marker of the localization of the pathological process; whether this is related to specific neuropathological conditions, such as Pick's disease, remains for the moment a matter of speculation.
authors.affiliation: Laboratorio di Neuropsicologia, Clinica Neurologica, University of Brescia, Italy. cappa@master.cci.unibs.it
authors.forename: S F
authors.initials: SF
authors.lastname: Cappa
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: C
authors.initials: C
authors.lastname: Messa
authors.forename: A
authors.initials: A
authors.lastname: Miozzo
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000328:Adult; D000368:Aged; D001039:Aphasia, Broca / Q000145:classification* / Q000175:diagnosis / Q000523:psychology; D003952:Diagnostic Imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D007807:Language Tests; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed