The comparative effects on plaque regrowth of phenolic chlorhexidine and anti-adhesive mouthrinses.
The inhibition of bacterial attachment to the tooth surface is one possible approach to plaque control. This study evaluated in vivo the plaque inhibitory action of a novel copolymer reported to have considerable antiadhesive properties in vitro. The study was a single blind, 5-treatment, randomised Latin square crossover design, incorporating balance for carry-over effects. The rinses were the antiadhesive (1%), the antiadhesive with 0.02% chlorhexidine, a 0.2% chlorhexidine rinse product, an essential oil/phenolic rinse product and water. 15 volunteers participated and on day 1 of each study period were rendered plaque-free, ceased toothcleaning and rinsed 2 x daily, under supervision, with the allocated formulation. On day 5, plaque was scored by index and area. Washout periods were 2 1/2 days. Alone or combined with chlorhexidine, the antiadhesive agent showed no effects greater than water. The chlorhexidine rinse was significantly more effective than the essential oil/phenolic rinse which in turn was significantly more effective than the other rinses.
Moran
J
J
Department of Prosthodontics, Dental School, Bristol, England.
Addy
M
M
Newcombe
R
R
Warren
P
P
D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D001422:Bacterial Adhesion / Q000187:drug effects; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control*; D003774:Dental Plaque Index; D003777:Dental Prophylaxis; D006801:Humans; D008297:Male; D009067:Mouthwashes; D009822:Oils, Volatile / Q000008:administration & dosage / Q000627:therapeutic use; D009910:Oral Hygiene; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D016037:Single-Blind Method; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014867:Water
D000891:Anti-Infective Agents, Local; C089490:M 239144; D009067:Mouthwashes; D009822:Oils, Volatile; D010636:Phenols; D011109:Polymethacrylic Acids; D013501:Surface-Active Agents; D014867:Water; D011092:Polyethylene Glycols; C010882:chlorhexidine gluconate; D002710:Chlorhexidine