2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
Hale
J J
JJ
Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Mills
S G
SG
MacCoss
M
M
Shah
S K
SK
Qi
H
H
Mathre
D J
DJ
Cascieri
M A
MA
Sadowski
S
S
Strader
C D
CD
MacIntyre
D E
DE
Metzger
J M
JM
D000284:Administration, Oral; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D009025:Morpholines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D064729:Neurokinin-1 Receptor Antagonists
C099406:L 742694; D009025:Morpholines; D064729:Neurokinin-1 Receptor Antagonists