Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.
Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a nitrate ester, its cardiovascular action differs from that of nitrate compounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0 mg) was compared with that of isosorbide dinitrate (ISDN; 1.0 mg) in 46 patients with or without ischemic heart disease (IHD). Dose-dependent right coronary dilating action was observed by intracoronary administration of nicorandil without any adverse effects. The same degree of right coronary dilation was achieved by the intracoronary application of equivalent doses of ISDN. We conclude that intracoronary administration of nicorandil is beneficial for the supportive treatment of IHD during coronary artery investigation and intervention without the risk of severe systemic hypotension.
Ejima
J
J
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kaneda
K
K
Moriyama
H
H
Ohmura
I
I
Maruyama
T
T
Kaji
Y
Y
Tsuda
Y
Y
Kanaya
S
S
Fujino
T
T
Niho
Y
Y
D000787:Angina Pectoris / Q000188:drug therapy / Q000473:pathology; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000473:pathology; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy / Q000473:pathology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D020108:Nicorandil; D012804:Sick Sinus Syndrome / Q000188:drug therapy / Q000473:pathology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil; D007548:Isosorbide Dinitrate