[Participation of a diazepam-binding inhibitor in the interaction between NAD and GABA-benzodiazepine receptor complex in synaptic membranes].
Diazepam-binding inhibitor isolated from synaptic membranes exerts a pronounced inhibitory effect on the specific benzodiazepine-receptor binding of 3H-flunitrazepam and simultaneously leads to an increase of synaptosomal uptake of 14C-GAMA. At the same time the inhibitor also depresses the specific binding of 14C-NAD by synaptic membranes, but displaying a greater effect. In both cases the inhibition was competent. Whether the isolated neuropeptide may act as an intermediary in the interaction with the reception system of NAD with GABA-benzodiazepine-receptor complex.
Fomenko
A I
AI
Parkhomets
P K
PK
Stepanenko
S P
SP
Donchenko
G V
GV
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D026261:Diazepam Binding Inhibitor; D005445:Flunitrazepam / Q000378:metabolism; D008297:Male; D009243:NAD / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D011963:Receptors, GABA-A; D009243:NAD; D005445:Flunitrazepam