Acetylcholine-induced prolongation of the QT interval in idiopathic long QT syndrome.
Intracoronary acetylcholine prolonged the QT interval in 5 patients with congenital long QT syndrome but not in subjects with normal QT intervals. Prolongation was not due to bradycardia or adrenergic drive, and atropine was suggested to attenuate the response.
Aizawa
Y
Y
The First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi, Japan.
Washizuka
T
T
Igarashi
Y
Y
Kitazawa
H
H
Chinushi
M
M
Abe
A
A
Shibata
A
A
D000109:Acetylcholine / Q000494:pharmacology*; D000293:Adolescent; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008133:Long QT Syndrome / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
D000109:Acetylcholine