title: Radiobiology of ultrasoft X rays. V. Modification of cell inactivation by dimethyl sulfoxide.
abstract: The effects of the radioprotector dimethyl sulfoxide (DMSO) were investigated for carbon-K (0.28 keV) and aluminum-K (1.47 keV) X rays compared with 60Co gamma rays for inactivation of mouse C3H 10T1/2 cells. The protection factor for 2 M DMSO was found to be 2.8 for both of the ultrasoft X-ray energies, which is not significantly different from the protection factor of 2.6 found for gamma rays. The results indicate that the proportion of scavengeable lethal damage from gamma and X rays does not depend on the proportion of the total energy that is deposited by low-energy electrons of relatively high ionization density.
authors.affiliation: Los Alamos National Laboratory, New Mexico, 87545, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Raju
authors.forename: M E
authors.initials: ME
authors.lastname: Schillaci
authors.forename: S G
authors.initials: SG
authors.lastname: Carpenter
authors.forename: D T
authors.initials: DT
authors.lastname: Goodhead
authors.forename: J F
authors.initials: JF
authors.lastname: Ward
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian; D005720:Gamma Rays; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014965:X-Rays
chemical_list: D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D004121:Dimethyl Sulfoxide