Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.
Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].
Dempcy
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Department of Chemistry, University of California, Santa Barbara 93106, USA.
Luo
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Bruice
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D001483:Base Sequence; D015195:Drug Design; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D006860:Hydrogen Bonding; D008961:Models, Structural; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry
D006146:Guanidines; D009843:Oligoribonucleotides; D012313:RNA