title: Source modeling of esophageal evoked potentials.
abstract: Evoked potentials can be recorded from the scalp after stimulation of the esophagus by balloon distension. The purpose of this study was to estimate the number and localization of sources contributing to the esophageal evoked potential (EEP). The EEP was recorded from 32 scalp electrodes in 5 healthy subjects. Spatio-temporal dipole modeling was performed in the time interval from 185 msec to 525 msec after stimulation (mean values). The EEP was best explained by the combined activity of 1 dipole located relatively high in the midline and 2 lateral dipoles. Given the anatomical projection of esophageal sensory fibers and the location of these dipoles the sources were probably located in the cingulate gyri and insular cortex. There was no evidence that sources in the lower brain-stem contributed to the scalp recorded EEP.
authors.affiliation: Department of Clinical Neurophysiology (F.02.230), Rudolf Magnus Research School in the Neurosciences, University Hospital Utrecht, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Franssen
authors.forename: B L
authors.initials: BL
authors.lastname: Weusten
authors.forename: G H
authors.initials: GH
authors.lastname: Wieneke
authors.forename: A J
authors.initials: AJ
authors.lastname: Smout
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D004947:Esophagus / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008959:Models, Neurological; D012535:Scalp / Q000502:physiology