title: Porosity reduction in bone cement at the cement-stem interface.
abstract: The fatigue failure of bone cement, leading to loosening of the stem, is likely to be one mode of failure of cemented total hip replacements. There is strong evidence that cracks in the cement are initiated at voids which act as stress risers, particularly at the cement-stem interface. The preferential formation of voids at this site results from shrinkage during polymerisation and the initiation of this process at the warmer cement-bone interface, which causes bone cement to shrink away from the stem. A reversal of the direction of polymerisation would shrink the cement on to the stem and reduce or eliminate the formation of voids at this interface. We have investigated this by implanting hip prostheses, at room temperature or preheated to 44 degrees C, into human cadaver femora kept at 37 degrees C. Two types of bone cement were either hand-mixed or vacuum-mixed before implantation. We found that the area of porosity at the cement-stem interface was dramatically reduced by preheating the stem and that the preheating temperature of 44 degrees C determined by computer analysis of transient heat transfer was the minimum required to induce initial polymerisation at the cement-stem interface. Temperature measurements taken during these experiments in vitro showed that preheating of the stem caused a negligible increase in the temperature of the bone. Reduction of porosity at the cement-stem interface could significantly increase the life of hip arthroplasties.
authors.affiliation: AO/ASIF Research Institute, Davos, Switzerland.
authors.forename: N E
authors.initials: NE
authors.lastname: Bishop
authors.forename: S
authors.initials: S
authors.lastname: Ferguson
authors.forename: S
authors.initials: S
authors.lastname: Tepic
mesh_terms: D001843:Bone Cements / Q000009:adverse effects / Q000737:chemistry* / Q000592:standards; D002102:Cadaver; D017076:Computer-Aided Design; D006622:Hip Prosthesis; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D011108:Polymers; D016062:Porosity; D011475:Prosthesis Failure; D013314:Stress, Mechanical; D013816:Thermodynamics
chemical_list: D001843:Bone Cements; D011108:Polymers