Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines.
We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM) and cytokines.
Beyreuther
K
K
ZMBH, Center for Molecular Biology, University of Heidelberg, Germany. bsa784@sun0.urz.uni-heidelberg.de
Multhaup
G
G
Mönning
U
U
Sandbrink
R
R
Beher
D
D
Hesse
L
L
Small
D H
DH
Masters
C L
CL
D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D016207:Cytokines / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans
D016564:Amyloid beta-Protein Precursor; D016207:Cytokines