title: An incremental dosing protocol for women with severe vaginal trichomoniasis and adverse reaction to metronidazole.
abstract: OBJECTIVE
  Our purpose was to develop and test an incremental dosing protocol for women with adverse reaction to metronidazole and severe symptomatic Trichomonas vaginitis.
  
  
  METHODS
  Two women with documented Trichomonas infection and presumed metronidazole allergy were initially treated with a number of alternative methods without success. With persistent severe symptoms associated with their infection, these women were admitted to the hospital and underwent an intravenous incremental metronidazole dosing protocol.
  
  
  RESULTS
  Both patients were successfully treated without adverse event. They are both symptom-free and apparently cured several months after treatment.
  
  
  CONCLUSIONS
  This protocol offers a new therapeutic option to women with adverse metronidazole reactions and severe symptomatic Trichomonas vaginitis resistant to treatment with nonmetronidazole therapy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, MI 48109-0718, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Pearlman
authors.forename: C
authors.initials: C
authors.lastname: Yashar
authors.forename: S
authors.initials: S
authors.lastname: Ernst
authors.forename: W
authors.initials: W
authors.lastname: Solomon
mesh_terms: D000994:Antitrichomonal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002985:Clinical Protocols; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
chemical_list: D000994:Antitrichomonal Agents; D008795:Metronidazole