title: The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease.
abstract: The insulin resistance syndrome has recently been implicated in the etiology of coronary heart disease, with a possible metabolic defect at the level of the adipocyte. We report the effects of a low- versus high-glycemic-index (LGI and HGI, respectively) diet on insulin and glucose response as assessed by oral glucose tolerance test (OGTT) and insulin-stimulated glucose uptake in isolated adipocytes in a group of 32 patients with advanced coronary heart disease. The area under the insulin curve following OGTT was significantly reduced after 4 weeks in the LGI group (P < .03), but not in the HGI group. Insulin-stimulated glucose uptake in isolated adipocytes harvested from a presternal fat biopsy was significantly greater following the LGI diet (P < .05). This study demonstrates that simple short-term dietary measures can improve insulin sensitivity in patients with coronary heart disease.
authors.affiliation: Department of Nutrition and Dietetics, Hammersmith Hospital, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Frost
authors.forename: B
authors.initials: B
authors.lastname: Keogh
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Akinsanya
authors.forename: A
authors.initials: A
authors.lastname: Leeds
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D003327:Coronary Disease / Q000178:diet therapy* / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin