title: Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.
abstract: Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].
authors.affiliation: Department of Chemistry, University of California, Santa Barbara 93106, USA.
authors.forename: R O
authors.initials: RO
authors.lastname: Dempcy
authors.forename: J
authors.initials: J
authors.lastname: Luo
authors.forename: T C
authors.initials: TC
authors.lastname: Bruice
mesh_terms: D001483:Base Sequence; D015195:Drug Design; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D006860:Hydrogen Bonding; D008961:Models, Structural; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006146:Guanidines; D009843:Oligoribonucleotides; D012313:RNA