title: Effectiveness of a thermal shape-memory patent ductus arteriosus occlusion coil.
abstract: A new shape-memory coil for transcatheter closure of the PDA was developed and evaluated in a dog PDA model. The coil is sensitive to temperature (composed of thermal shape-memory nickel-titanium). The coil was delivered to and implanted in the PDA model with a 5F catheter through the femoral artery. The PDA model was made in 14 dogs by infrarenal aorta banding (diameter 2.0 +/- 0.6 mm; length 2.9 +/- 0.1 mm). Coils were implanted in 10 dogs, whereas the other 4 dogs served as controls. Complete occlusion of the PDA model was confirmed by angiography 24 hours after the coil implantation in 7 of 10 dogs, whereas small residual flow was noted even 2 weeks after the coil implantation in the other 3 dogs. The PDA model internal diameter in the dogs with complete occlusion (1.8 +/- 0.2 mm) was significantly smaller than the diameter in dogs with residual flow (2.9 +/- 0.4 mm, P < 0.05). In the 4 control dogs, the PDA model remained patent 2 weeks after the banding. We conclude that the transcatheter occlusion with the shape-memory coil was effective in the small-diameter PDA model.
authors.affiliation: Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Shiraishi
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Yanagisawa
mesh_terms: D000818:Animals; D002404:Catheterization; D004195:Disease Models, Animal; D004285:Dogs; D004374:Ductus Arteriosus, Patent / Q000628:therapy*; D009532:Nickel; D019736:Prostheses and Implants; D014025:Titanium
chemical_list: D009532:Nickel; D014025:Titanium