Poly ICLC inhibits Plasmodium cynomolgi B malaria infection in rhesus monkeys.
Prophylatic treatment with a single dose of 1.0 or 2.0 mg/kg (body weight) of polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (Poly ICLC), a potent interferon (IFN) inducer and immune enhancer, 18 h before intravenous inoculation of sporozoites (1.04 x 10(5)-0.70 x 10(6) sporozoites) of Plasmodium cynomolgi B in the rhesus monkey, completely abolished the infectivity of sporozoites. The inhibitory effect of Poly ICLC is dose dependent in monkeys infected with P. cynomolgi B sporozoites. Treatment with lower doses of Poly ICLC (0.5 mg/kg) provided significant protection, but the lowest dose of Poly ICLC used (0.1 mg/kg) failed to provide any protection. Prophylactic treatment with Poly ICLC, however, had no protective effect against trophozoite-induced infection.
Puri
S K
SK
Central Drug Research Institute, Lucknow, India.
Dutta
G P
GP
Levy
H B
HB
Maheshwari
R K
RK
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D007155:Immunologic Factors / Q000627:therapeutic use*; D007369:Interferon Inducers / Q000627:therapeutic use*; D008253:Macaca mulatta; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D016789:Plasmodium cynomolgi; D011070:Poly I-C / Q000627:therapeutic use*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D007155:Immunologic Factors; D007369:Interferon Inducers; D011107:Polylysine; C019531:poly ICLC; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C