title: A primary cutaneous non-T, non-B CD4+, CD56+ lymphoma.
abstract: BACKGROUND
  Cutaneous lymphomas are heterogeneous clonal lymphoproliferative disorders originating from B or T lymphocytes.
  
  
  METHODS
  We describe a patient with a unique primary cutaneous lymphoma characterized by a bruise-like aspect of the skin lesions, a CD4+, CD43+, CD56+, CD2-, CD3-, CD8-, T-cell receptor-negative phenotype of the medium-sized to large lymphoid tumor cells and an undetermined genotype (T-cell receptor beta and immunoglobulin heavy chain in germline configuration, no clonal T-cell receptor gamma population as detected after analysis with polymerase chain reaction combined with denaturing gradient gel electrophoresis) and fast relapse after radiotherapy.
  
  
  CONCLUSIONS
  This non-B, non-T cutaneous lymphoma cannot be classified by any current lymphoma classification. It seems to represent a new disease entity with peculiar clinical, histologic, and molecular features.
authors.affiliation: Department of Dermatology, University of Zürich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Dummer
authors.forename: N
authors.initials: N
authors.lastname: Potoczna
authors.forename: A C
authors.initials: AC
authors.lastname: Häffner
authors.forename: D R
authors.initials: DR
authors.lastname: Zimmermann
authors.forename: S
authors.initials: S
authors.lastname: Gilardi
authors.forename: G
authors.initials: G
authors.lastname: Burg
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis*; D019002:CD56 Antigen / Q000032:analysis*; D005145:Face; D005260:Female; D006801:Humans; D007866:Leg; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; D015704:CD4 Antigens; D019002:CD56 Antigen