The HIR protein family: isolation and characterization of a complete murine cDNA.
A full-length cDNA has been isolated for the murine homolog of the human HIRA protein, a member of the HIR family of nuclear proteins that is encoded from the chromosome 22 region critical for the DiGeorge syndrome. This family also contains Hir1p and Hir2p, two proteins identified as regulators of histone gene transcription in yeast. The murine and human amino acid sequences are 95.3% identical, with a striking 99.2% identity in the N-terminal WD repeat domain that is characteristic of the family. The two cDNAs are highly conserved within the coding regions, but also in the entire 5' untranslated region and in a strikingly long stretch of nucleotides in the 3' untranslated region.
Scamps
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Laboratorie de Biologie des Tumeurs Humaines, CNRS URA 1156, Institut Gustave Roussy, Villejuif, France.
Lorain
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Lamour
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Lipinski
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018797:Cell Cycle Proteins; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics*; D015723:Gene Library; D056488:Histone Chaperones; D006801:Humans; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics*
D018797:Cell Cycle Proteins; D018076:DNA, Complementary; C086057:HIRA protein, human; C484187:Hira protein, mouse; D056488:Histone Chaperones; D009687:Nuclear Proteins; D014157:Transcription Factors