Decreased expression of both Fc gamma RII and Fc gamma RIII mRNA in leukemic granulocytes.
Morphologically mature granulocytes from patients with chronic myeloid leukemia exhibit a defect in internalization of heat-aggregated IgG. In this study, we investigate the status of the steady-state levels of the mRNA for the two receptors for IgG, Fc gamma RII and Fc gamma RIII, as a step towards understanding the molecular basis of the defect and in turn the discordant maturation of the leukemic cells. Our data show that the mRNA for both receptors is lower in the leukemic cells relative to the normal cells. This may be one of the causes for the defective endocytosis.
Kant
A
A
Cancer Research Institute, Bombay, India.
Advani
S
S
Zingde
S
S
D015152:Blotting, Northern; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism*; D017452:Receptors, IgG / Q000235:genetics*
D012333:RNA, Messenger; D017452:Receptors, IgG