Cloning the gene encoding Schistosoma mansoni p50, an immunophilin.
A 2.2-kb fragment of genomic DNA encoding Schistosoma mansoni immunophilin p50 (Smp50) was identified on a 14-kb genomic clone. The sequence of Smp50 reveals seven exons interrupted by six small introns ranging from 28-35 bp in size. The transcription start point, defined by primer extension analysis of schistosome RNA, begins at 30 bp upstream from the start AUG codon. Smp50 lacks a TATA box and appears to be a single-copy gene.
Kiang
D
D
Department of Microbiology, State University of New York, Buffalo 14214, USA.
Karim
A M
AM
LoVerde
P T
PT
D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D003001:Cloning, Molecular; D016384:Consensus Sequence; D018509:DNA, Helminth / Q000235:genetics; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D018510:RNA, Helminth / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012550:Schistosoma mansoni / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D016559:Tacrolimus / Q000378:metabolism; D022021:Tacrolimus Binding Proteins
D002352:Carrier Proteins; D018509:DNA, Helminth; D015801:Helminth Proteins; D018510:RNA, Helminth; D012333:RNA, Messenger; D022021:Tacrolimus Binding Proteins; C099213:p50 immunophilin protein, Schistosoma mansoni; D016559:Tacrolimus