Allogeneic marrow transplantation in a cat with acute myeloid leukemia.
A listless, anorectic 2-year-old cat was found to have a normocytic, nonregenerative anemia. A diagnosis of acute myeloid leukemia type M6Er was made. Because the cat was young, had negative FeLV and feline immunodeficiency virus test results, had a sibling that could be used as a bone marrow donor, had received only 1 transfusion, and was in good health other than being anemic, allogeneic bone marrow transplantation (BMT) was attempted using marrow from the cat's sibling. The most life-threatening complication following BMT was hemorrhage caused by severe thrombocytopenia. Complete hematopoietic engraftment was evident 36 days after BMT. The cat then was discharged to its owner. In the first year, the cat continued to improve with the exception of an intractable dermatophytosis, which resolved eventually. The cat continues to do well 4 years after BMT. To our knowledge, this represents the first report of successful allogeneic BMT for a cat with acute myeloid leukemia.
Gasper
P W
PW
Department of Pathology, Colorado State University, Fort Collins 80523, USA.
Rosen
D K
DK
Fulton
R
R
D000740:Anemia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D001803:Blood Transfusion / Q000662:veterinary; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000662:veterinary*; D002371:Cat Diseases / Q000209:etiology / Q000628:therapy*; D002415:Cats; D006470:Hemorrhage / Q000209:etiology / Q000662:veterinary; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D008297:Male; D013921:Thrombocytopenia / Q000150:complications / Q000209:etiology / Q000662:veterinary; D014184:Transplantation, Homologous / Q000662:veterinary