title: Effects of topical anandamides on intraocular pressure in normotensive rabbits.
abstract: A series of anandamide-type compounds were synthesized and studied for their effect on the intraocular pressure (IOP) of normotensive pigmented rabbits. Each test compound was dissolved in an aqueous 2-hydroxypropyl-beta-cyclodextrin solution and administered (31.25 - 62.5 micrograms) unilaterally to the eye. The most promising anandamides caused a statistically significant reduction of IOP in treated eyes, usually preceded by an initial transient elevation of IOP, compared to saline controls. In the contralateral untreated eyes, only a marginal or short hypotensive response was observed. Indomethacin pre-treatment (12.5 mg, s.c.) eliminated the IOP response to administered anandamides and arachidonic acid.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kuopio, Finland.
authors.forename: D W
authors.initials: DW
authors.lastname: Pate
authors.forename: K
authors.initials: K
authors.lastname: Järvinen
authors.forename: A
authors.initials: A
authors.lastname: Urtti
authors.forename: P
authors.initials: P
authors.lastname: Jarho
authors.forename: M
authors.initials: M
authors.lastname: Fich
authors.forename: V
authors.initials: V
authors.lastname: Mahadevan
authors.forename: T
authors.initials: T
authors.lastname: Järvinen
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002186:Cannabinoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D002186:Cannabinoids; D007213:Indomethacin