title: Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.
abstract: In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.
authors.affiliation: Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Mariathasan
authors.forename: M H
authors.initials: MH
authors.lastname: Nahm
authors.forename: F
authors.initials: F
authors.lastname: Baranyay
authors.forename: J J
authors.initials: JJ
authors.lastname: Peschon
authors.forename: D D
authors.initials: DD
authors.lastname: Chaplin
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D018390:Gene Targeting; D018858:Germinal Center / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D007114:Immunization; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000502:physiology*; D013154:Spleen / Q000033:anatomy & histology / Q000276:immunology*
chemical_list: D008233:Lymphotoxin-alpha; D018124:Receptors, Tumor Necrosis Factor