title: Relationship of the Tufts Quantitative Neuromuscular Exam (TQNE) and the Sickness Impact Profile (SIP) in measuring progression of ALS. SSNJV/CNTF ALS Study Group.
abstract: The Tufts Quantitative Neuromuscular Exam (TQNE) is a standardized tool for measuring muscle strength and pulmonary function in patients with amyotrophic lateral sclerosis (ALS). We describe the relationship of TQNE scores to functional disability and health-related quality of life as measured by the Sickness Impact Profile (SIP) in 524 ALS patients. There was a significant relationship (p < 0.0001) between TQNE and SIP scores, both in cross section and over time. TQNE scores strongly relate to ALS patients' quality of life and ability to perform activities of daily living.
authors.affiliation: Department of Neurology, University of California at San Francisco, USA.
authors.forename: D
authors.initials: D
authors.lastname: McGuire
authors.forename: L
authors.initials: L
authors.lastname: Garrison
authors.forename: C
authors.initials: C
authors.lastname: Armon
authors.forename: R
authors.initials: R
authors.lastname: Barohn
authors.forename: W
authors.initials: W
authors.lastname: Bryan
authors.forename: R
authors.initials: R
authors.lastname: Miller
authors.forename: G
authors.initials: G
authors.lastname: Parry
authors.forename: J
authors.initials: J
authors.lastname: Petajan
authors.forename: M
authors.initials: M
authors.lastname: Ross
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology* / Q000523:psychology*; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009460:Neurologic Examination; D010808:Physical Examination; D011788:Quality of Life; D012044:Regression Analysis; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires