title: decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut.
abstract: dishevelled, shaggy/zeste-white 3 and armadillo are required for transmission of the wingless signal in the Drosophila epidermis. We show that these genes act in the same epistatic order in the embryonic midgut to transmit the wingless signal. In addition to mediating transcriptional stimulation of the homeotic genes Ultrabithorax and labial, they are also required for transcriptional repression of labial by high wingless levels. Efficient labial expression thus only occurs within a window of intermediate wingless pathway activity. Finally, the shaggy/zeste-white 3 mutants revealed that wingless signalling can stimulate decapentaplegic transcription in the absence of Ultrabithorax, identifying decapentaplegic as a target gene of wingless. As decapentaplegic itself is required for wingless expression in the midgut, this represents a positive feed-back loop between two cell groups signalling to each other to stimulate each other's signal production.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK.
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Hoppler
authors.forename: S
authors.initials: S
authors.lastname: Eresh
authors.forename: M
authors.initials: M
authors.lastname: Bienz
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D051186:Armadillo Domain Proteins; D004268:DNA-Binding Proteins / Q000502:physiology; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology*; D004627:Embryonic Induction; D004707:Endoderm / Q000166:cytology; D004843:Epistasis, Genetic; D018507:Gene Expression Regulation, Developmental; D038362:Glycogen Synthase Kinase 3; D018398:Homeodomain Proteins / Q000502:physiology; D007301:Insect Hormones / Q000502:physiology*; D007422:Intestines / Q000196:embryology*; D009024:Morphogenesis; D010750:Phosphoproteins; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D015534:Trans-Activators; D014157:Transcription Factors; D051155:Wnt1 Protein
chemical_list: C495305:ARM protein, Drosophila; D048868:Adaptor Proteins, Signal Transducing; D051186:Armadillo Domain Proteins; D004268:DNA-Binding Proteins; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D010750:Phosphoproteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; C066177:Ubx protein, Drosophila; D051155:Wnt1 Protein; C064196:dpp protein, Drosophila; C000606588:dsh protein, Drosophila; C059843:lab protein, Drosophila; C074622:wg protein, Drosophila; D017346:Protein Serine-Threonine Kinases; C080335:Sgg protein, Drosophila; D038362:Glycogen Synthase Kinase 3