title: Lung mechanics and dyspnea after lung transplantation for chronic airflow obstruction.
abstract: Single lung transplantation (SLT) is widely used to treat chronic airflow obstruction (CAO). During exercise the native lung should increase end-expiratory lung volume (EELV) and result in a different respiratory sensation compared with double lung transplantation (DLT). Eight SLT recipients and 12 DLT recipients demonstrated a similar maximal work load and achieved VO2. VEmax/MVV was 67.2 +/- 4.0% in SLT recipients and 48.5 +/- 3.6% in DLT recipients (p = 0.003). All SLT recipients demonstrated an increase in EELV during exercise, which was seen in only three of 12 DLT recipients. The change in absolute EELV from rest to peak exercise was different between SLT recipients (+0.37 +/- 0.10 L) and DLT recipients (-0.10 +/- 0.06, p = 0.0002). Tidal flow volume loop analysis demonstrated encroachment of the expiratory limb in four of seven SLT patients but in only one of 12 DLT recipients. A lesser peak breathlessness in DLT recipients approached statistical significance (p = 0.051), although the relation of respiratory sensation versus VE or VO2% predicted did not differ between the two groups. EELV increases in SLT recipients at peak exercise, although overall aerobic response is preserved and respiratory sensation is similar.
authors.affiliation: Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, USA.
authors.forename: F J
authors.initials: FJ
authors.lastname: Martinez
authors.forename: J B
authors.initials: JB
authors.lastname: Orens
authors.forename: R I
authors.initials: RI
authors.lastname: Whyte
authors.forename: L
authors.initials: L
authors.lastname: Graf
authors.forename: F S
authors.initials: FS
authors.lastname: Becker
authors.forename: J P
authors.initials: JP
authors.lastname: Lynch
mesh_terms: D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology*; D005544:Forecasting; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008173:Lung Diseases, Obstructive / Q000503:physiopathology / Q000601:surgery*; D016040:Lung Transplantation / Q000502:physiology; D008176:Lung Volume Measurements; D008449:Maximal Expiratory Flow-Volume Curves; D008451:Maximal Voluntary Ventilation; D008875:Middle Aged; D010101:Oxygen Consumption; D005082:Physical Exertion; D012123:Pulmonary Ventilation / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000503:physiopathology; D012677:Sensation; D013990:Tidal Volume