title: Human herpesvirus-6-associated exanthema in a patient with acute lymphocytic leukaemia.
abstract: We report the first case of human herpesvirus-6 (HHV-6) associated exanthema in a patient with acute lymphocytic leukaemia (ALL). We analysed DNA extracted from an exanthematous lesion using the polymerase chain reaction (PCR). DNA was positive for HHV-6 but negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus. Immunohistochemical staining of the skin with monoclonal antibody against (HHV-6 confirmed the infection. The possibility of HHV-6 infection should be considered when an atypical skin rash is seen in patients with ALL.
authors.affiliation: Department of Haematology / Chemotherapy, Clinical Research Institute, Kanagawa Cancer Centre, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: A
authors.initials: A
authors.lastname: Maruta
authors.forename: N
authors.initials: N
authors.lastname: Tomita
authors.forename: J
authors.initials: J
authors.lastname: Taguchi
authors.forename: R
authors.initials: R
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: F
authors.initials: F
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Okubo
mesh_terms: D000328:Adult; D005077:Exanthema Subitum / Q000150:complications*; D015654:Herpesvirus 6, Human; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012874:Skin Diseases, Infectious / Q000150:complications*