The effect of Beraprost sodium on the survival of subcutaneous transferred jejunum after vascular pedicle interruption in a rat model.
Beraprost sodium, a stable PGI2 analog, having antiplatelet aggregation and vasodilating actions, was tested in a rat subcutaneous heterotopic jejunal model for its ability to improve survival after vascular pedicle interruption. Forth Sprague-Dawley rats were divided into four groups: Group 1 (control, ligation of pedicle on postoperative day 5); Group 2 (Beraprost sodium, ligation on day 5); Group 3 (control, ligation on day 7); and Group 4 (Beraprost sodium, ligation on day 7). The resulting viability rates were: Group 1 = 0 percent, Group 2 = 40 percent, Group 3 = 30 percent, Group 4 = 90 percent. These results indicate that the administration of Beraprost sodium facilitates the neovascularization of the transferred intestine and shortens the time required for viability of the transferred tissue, after interruption of the vascular pedicle.
Alexandrou
K
K
Department of Plastic Surgery, Kagawa Medical School, Japan.
Hata
Y
Y
Matsuka
K
K
Ito
O
O
Matsuda
H
H
Furuichi
H
H
Ishizu
N
N
D000009:Abdominal Muscles; D000818:Animals; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006085:Graft Survival / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology / Q000637:transplantation*; D009336:Necrosis; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016042:Transplantation, Heterotopic
D010975:Platelet Aggregation Inhibitors; C048081:beraprost; D011464:Epoprostenol