title: Twenty-year review of a breast cancer screening project. Ninety-five percent survival of patients with nonpalpable cancers.
abstract: BACKGROUND
  In 1973, the Breast Cancer Detection Demonstration Project at the Georgia Baptist Medical Center began screening supposedly asymptomatic women for breast cancer. The project has been reviewed and now 20 years later, the follow-up of those women with detected cancer who were matched with a group of the original cohort with negative screens is reported. Early criticism of the project was its "lead-time bias," which, after 20 years, should pose no problem.
  
  
  METHODS
  Approximately 9043 women were screened for 5 years. The remainder of the total of 10,000 women were screened at the Emory University Department of Radiology. The 128 patients who were found to have breast cancer were observed for over 20 years. A matched group of 1609, who had negative results when originally screened, were also observed for 20 years.
  
  
  RESULTS
  After 20 years, approximately 86% of the 128 women diagnosed with breast cancer were still free of disease, including 88.3% of women with lesions of less than 1.1 cm and 95.1% of those with nonpalpable carcinomas.
  
  
  CONCLUSIONS
  Over 95% of the 67 women with nonpalpable lesions were alive after 20 years of follow-up. Women not screened yearly tend to have larger lesions than those screened on a regular basis. Regular screening is currently the best way to control this disease.
authors.affiliation: Harris Cancer Center, Georgia Baptist Medical Center, Atlanta 30312, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Letton
authors.forename: E M
authors.initials: EM
authors.lastname: Mason
authors.forename: B J
authors.initials: BJ
authors.lastname: Ramshaw
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality* / Q000517:prevention & control / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D008327:Mammography; D008403:Mass Screening / Q000379:methods*; D008408:Mastectomy; D008875:Middle Aged; D015996:Survival Rate; D013997:Time Factors