title: Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures.
abstract: Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5-3 microM and was specific for angiotensin II AT2.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065, USA.
authors.forename: S
authors.initials: S
authors.lastname: Stevens-Miles
authors.forename: M A
authors.initials: MA
authors.lastname: Goetz
authors.forename: G F
authors.initials: GF
authors.lastname: Bills
authors.forename: R A
authors.initials: RA
authors.lastname: Giacobbe
authors.forename: J S
authors.initials: JS
authors.lastname: Tkacz
authors.forename: R S
authors.initials: RS
authors.lastname: Chang
authors.forename: M
authors.initials: M
authors.lastname: Mojena
authors.forename: I
authors.initials: I
authors.lastname: Martin
authors.forename: M T
authors.initials: MT
authors.lastname: Diez
authors.forename: F
authors.initials: F
authors.lastname: Pelaez
authors.forename: O D
authors.initials: OD
authors.lastname: Hensens
authors.forename: T
authors.initials: T
authors.lastname: Jones
authors.forename: R W
authors.initials: RW
authors.lastname: Burg
authors.forename: Y L
authors.initials: YL
authors.lastname: Kong
authors.forename: L
authors.initials: L
authors.lastname: Huang
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000804:Angiotensin II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D005285:Fermentation; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000737:chemistry*; D051381:Rats
chemical_list: D001578:Benzopyrans; C099196:cytosporin A; C099197:cytosporin B; C099198:cytosporin C; D000804:Angiotensin II