Epithelial cell proliferation in nasal polyps could be up-regulated by platelet-derived growth factor.
The modifications of epithelial differentiation and proliferation observed in nasal polyps (NP) could be related to local secretion of growth factors, among which platelet-derived growth factor (PDGF) could play a key role. We therefore prospectively studied, by immunohistochemistry, proliferating cell nuclear antigen (PCNA, an S-phase cell marker), PDGF, and CD-68 (activated macrophages marker) expression in NP and inferior turbinate mucosa (NM) in 11 patients. Our data show that PCNA and PDGF expression are increased in NP epithelium, while CD-68 expression is increased in NP epithelium and lamina propria when compared to NM. Increased local PDGF secretion by numerous activated macrophages could therefore be involved in epithelial cell proliferation up-regulation in NP. PDGF could also be involved in the pathogenesis of NP via its connective tissue remodeling actions.
Coste
A
A
Service d'ORL et de Chirurgue Cervico-Faciale, Hôpitaux Henri Mondor et Intercommunal de Créteil, France.
Wang
Q P
QP
Roudot-Thoraval
F
F
Chapelin
C
C
Bedbeder
P
P
Poron
F
F
Peynègre
R
R
Escudier
E
E
D015703:Antigens, CD / Q000096:biosynthesis; D002455:Cell Division; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology*; D009298:Nasal Polyps / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D011446:Prospective Studies; D015854:Up-Regulation
D015703:Antigens, CD; D010982:Platelet-Derived Growth Factor; D018809:Proliferating Cell Nuclear Antigen