Silent myocardial infarction in Wegener's granulomatosis.
Histological cardiac abnormalities in Wegener's granulomatosis can frequently be demonstrated at post-mortem examination, but clinically significant cardiac involvement is rare. We describe a massive silent myocardial infarction leading to intractable heart failure and death in a young man with Wegener's granulomatosis, occurring at a time when other features of the disease were responding to aggressive immunosuppression.
Lawson
T M
TM
Department of Rheumatology, University Hospital of Wales, Cardiff.
Williams
B D
BD
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D004562:Electrocardiography; D017809:Fatal Outcome; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D008775:Methylprednisolone