title: Frequency of gastric pacesetter potential depends on volume and site of distension.
abstract: Little is known about the response of the frequency of gastric pacesetter potential (PP) to luminal distension. When volume distension occurs as a result of a meal, gastric emptying may play an important role, since the site of distension shifts as the meal is displaced from the stomach to the small bowel. In this study, using does equipped with duodenal fistulas and serosal electrodes on the antrum, we compared the frequency of gastric PP during the course of gastric emptying while isolating the volume distension to either the stomach or the small bowel. We found that 1) the frequency of gastric PP decreased linearly with greater initial meal volume when volume distension was isolated to either the stomach -P<0.05, analysis of variance (ANOVA)- or small bowel (P<0.01, ANOVA), and 2) the frequency of gastric PP decreased linearly with increased volume remaining in the stomach or increased volume entering the small intestine. We conclude that the frequency of gastric PP depends on the volume and site of distension.
authors.affiliation: Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles 90048-1869, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: X T
authors.initials: XT
authors.lastname: Zhao
authors.forename: B
authors.initials: B
authors.lastname: Chung
authors.forename: Y G
authors.initials: YG
authors.lastname: GU
authors.forename: J D
authors.initials: JD
authors.lastname: Elashoff
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000502:physiology; D004435:Eating; D005402:Fistula; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D007421:Intestine, Small / Q000502:physiology*; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D013270:Stomach / Q000502:physiology*; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
chemical_list: D016284:Technetium Tc 99m Pentetate