title: Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells.
abstract: Programmed cell death is first observed at stage 11 of embryogenesis in Drosophila. The systematic removal of apoptotic cells is mediated by cells that are derived from the procephalic mesoderm and differentiate into macrophages. We describe a macrophage receptor for apoptotic cells. This receptor, croquemort (catcher of death), is a member of the CD36 superfamily. Croquemort-mediated phagocytosis represents the concept that phagocytosis evolved primarily as a cellular process for the removal of effete cells. Our findings support the idea that the primordial function of macrophages may have been in tissue modeling and that their adapted role is in host defense.
authors.affiliation: Division of Hematology, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Franc
authors.forename: J L
authors.initials: JL
authors.lastname: Dimarcq
authors.forename: M
authors.initials: M
authors.lastname: Lagueux
authors.forename: J
authors.initials: J
authors.lastname: Hoffmann
authors.forename: R A
authors.initials: RA
authors.lastname: Ezekowitz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001483:Base Sequence; D018955:CD36 Antigens / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D002460:Cell Line; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000276:immunology*; D004625:Embryo, Nonmammalian / Q000737:chemistry / Q000276:immunology; D047108:Embryonic Development; D006434:Hemocytes / Q000737:chemistry / Q000276:immunology*; D008264:Macrophages / Q000737:chemistry / Q000276:immunology*; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000737:chemistry / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism; D051116:Receptors, Scavenger
chemical_list: D018955:CD36 Antigens; D029721:Drosophila Proteins; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; C099526:crq protein, Drosophila