title: The Santa Lucia strain of Plasmodium falciparum as a model for vaccine studies. I. Development in Aotus lemurinus griseimembra monkeys.
abstract: The Santa Lucia strain of Plasmodium falciparum and the Aotus lemurinus griseimembra monkey are proposed as models for the testing of sporozoite vaccines and transmission-blocking vaccines. Approximately 85% of splenectomized monkeys were infected when fed upon by 10 or more heavily infected Anopheles freeborni mosquitoes. Sporozoite-induced infections in monkeys with or without previous infection with P. vivax readily infected mosquitoes, thus making them candidates for testing transmission-blocking vaccines.
authors.affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Collins
authors.forename: G G
authors.initials: GG
authors.lastname: Galland
authors.forename: J S
authors.initials: JS
authors.lastname: Sullivan
authors.forename: C L
authors.initials: CL
authors.lastname: Morris
authors.forename: B B
authors.initials: BB
authors.lastname: Richardson
authors.forename: J M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D001029:Aotus trivirgatus / Q000469:parasitology*; D002675:Child, Preschool; D004195:Disease Models, Animal; D004544:El Salvador; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000469:parasitology / Q000517:prevention & control* / Q000635:transmission; D018512:Parasitemia / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology*; D013156:Splenectomy
chemical_list: D017780:Malaria Vaccines