Structural and functional changes in the canine shoulder after cessation of immobilization.
The functional and structural consequences of remobilization of the glenohumeral joint after 12 weeks of immobilization were studied in 10 beagle dogs. The dogs were grouped in pairs: 2 were used as controls, and in 8 others 1 forelimb was immobilized. At the end of 12 weeks, 2 dogs in the experimental group were euthanized, as were the 2 dogs used as controls. The cast was removed from the other 6 dogs, and the remobilized animals were euthanized in pairs at the end of 4, 8, and 12 weeks. It was found that after 12 weeks of immobilization, the passive range of motion was markedly impaired, intraarticular pressure was raised during movements, and the filling volume of the joint cavity was reduced. Histologically, the capsule showed synovial lining hyperplasia and vascular proliferation in the wall. Immunohistochemical labeling for collagen Types I and III failed to show an increase of fibrous collagens in the capsular wall. Both the functional and structural changes were unaltered after 4 weeks of remobilization, but after 8 weeks they began to reverse, and they returned to normal levels after 12 weeks. Both functional and structural changes after 12 weeks of immobilization of the uninjured glenohumeral joint are reversible by remobilization. The collagen composition of the capsule seems unrelated to the degree of capsular contraction that occurs during 12 weeks of immobilization and subsequent remobilization.
Schollmeier
G
G
Bone and Joint Research Laboratory, Faculty of Medicine, University of Ottawa, Ontario, Canada.
Sarkar
K
K
Fukuhara
K
K
Uhthoff
H K
HK
D000818:Animals; D003094:Collagen / Q000032:analysis; D004285:Dogs; D005260:Female; D006965:Hyperplasia; D007103:Immobilization / Q000009:adverse effects*; D017746:Joint Capsule / Q000737:chemistry; D007592:Joint Diseases / Q000209:etiology / Q000503:physiopathology; D011312:Pressure; D016059:Range of Motion, Articular; D012785:Shoulder Joint / Q000033:anatomy & histology / Q000503:physiopathology*; D013583:Synovial Membrane / Q000473:pathology; D013997:Time Factors
D003094:Collagen