The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: in vivo and in vitro studies.
Ieiri
I
I
Division of Pharmaceutical Science, Kyushu University, Fukuoka, Japan.
Goto
W
W
Hirata
K
K
Toshitani
A
A
Imayama
S
S
Ohyama
Y
Y
Yamada
H
H
Ohtsubo
K
K
Higuchi
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D013237:Stereoisomerism
D000927:Anticonvulsants; C027364:5-(3-hydroxyphenyl)-5-phenylhydantoin; D010672:Phenytoin; D004247:DNA