title: Anti-MAG and anti-SGPG antibodies in neuropathy.
abstract: We compared the binding of human antibodies from patients with neuropathy to the myelin-associated glycoprotein (MAG), to its cross-reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme-linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti-MAG or -SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone.
authors.affiliation: Department of Neurology, Columbia Presbyterian Medical Center, New York, USA.
authors.forename: L
authors.initials: L
authors.lastname: Van den Berg
authors.forename: A P
authors.initials: AP
authors.lastname: Hays
authors.forename: E
authors.initials: E
authors.lastname: Nobile-Orazio
authors.forename: L J
authors.initials: LJ
authors.lastname: Kinsella
authors.forename: E
authors.initials: E
authors.lastname: Manfredini
authors.forename: M
authors.initials: M
authors.lastname: Corbo
authors.forename: G
authors.initials: G
authors.lastname: Rosoklija
authors.forename: D S
authors.initials: DS
authors.lastname: Younger
authors.forename: R E
authors.initials: RE
authors.lastname: Lovelace
authors.forename: W
authors.initials: W
authors.lastname: Trojaborg
authors.forename: D E
authors.initials: DE
authors.lastname: Lange
authors.forename: S
authors.initials: S
authors.lastname: Goldstein
authors.forename: J S
authors.initials: JS
authors.lastname: Delfiner
authors.forename: S A
authors.initials: SA
authors.lastname: Sadiq
authors.forename: W H
authors.initials: WH
authors.lastname: Sherman
authors.forename: N
authors.initials: N
authors.lastname: Latov
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005915:Globosides / Q000276:immunology*; D006031:Glycosylation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology; D018992:Myelin-Associated Glycoprotein / Q000276:immunology* / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000276:immunology*; D012678:Sensation Disorders / Q000276:immunology
chemical_list: D001323:Autoantibodies; D005915:Globosides; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; C051917:sulfate-3-glucuronyl paragloboside