title: Late contralateral hyperhidrosis in lateral medullary infarcts.
abstract: OBJECTIVE
  This study describes unilateral increases of sweating reactions observed in the months after contralateral medullary infarct; evaluation of sympathetic cutaneous response may help to explain sweating disorders.
  
  
  METHODS
  After the discovery of the clinical phenomenon in one case, patients admitted between 1990 and 1993 were systematically evaluated clinically and electrophysiologically. In a group of five patients presenting with lateral or dorsal medullary lesions, two exhibited an increase of contralateral sweating reactions that appeared 6 to 8 months after stroke, were elicited by effort and exposure to heat and stress, and were more severe over the forehead, face, and upper trunk. In one case, this was clinically associated with an absence of sweating on the side of the lesion. During the late phase after stroke, in three patients presenting with lateral medullary lesions, electrophysiological evaluation revealed significant asymmetry of the sympathetic skin response, which was higher on the side contralateral to the lesion than on the ipsilateral side. In one patient, no response could be elicited by stimulations applied on the side of the lesion.
  
  
  CONCLUSIONS
  Contralateral hyperhidrosis can be observed in the late phase after lateral medullary infarct and is likely due to lesion of the sympathetic pathway passing through the lateral medulla, which inhibits sudomotor neurons. Evaluation of sympathetic skin response may help to explain such clinical disorders.
authors.affiliation: Service de Rééducation et Convalescence Neurologiques, Centre Hospitalier Universitaire, Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Rousseaux
authors.forename: J F
authors.initials: JF
authors.lastname: Hurtevent
authors.forename: C
authors.initials: C
authors.lastname: Benaim
authors.forename: F
authors.initials: F
authors.lastname: Cassim
mesh_terms: D000328:Adult; D002544:Cerebral Infarction / Q000503:physiopathology*; D004558:Electric Stimulation; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D006945:Hyperhidrosis / Q000209:etiology*; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008526:Medulla Oblongata; D008875:Middle Aged; D012018:Reflex; D012867:Skin / Q000294:innervation; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013997:Time Factors