Is there a circadian variation in plasma concentrations of etoposide given by prolonged continuous infusion?
The prolonged continuous infusion of low-dose etoposide is a new approach to treating cancer. Whether or not a circadian variation in the plasma levels of etoposide existed was investigated in nine patients with non-small-cell lung cancer. Etoposide was infused for 14 days and blood samples were obtained every 4 h for 1 day. There was no significant circadian variation, and the observed small within-day variations seemed to lack clinical significance.
Ando
Y
Y
Department of Internal Medicine, Nagoya University School of Medicine, Showa-ku, Nagoya, Japan.
Minami
H
H
Sakai
S
S
Shimokata
K
K
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D002940:Circadian Rhythm; D005047:Etoposide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D005047:Etoposide