title: Gamma delta T cells are secondary participants in acute graft-versus-host reactions initiated by CD4+ alpha beta T cells.
abstract: To examine the role of T cell subpopulations in an acute graft-versus-host (GVH) reaction, gamma delta T cells and alpha beta T cells expressing one of the two prototypic V beta families were negatively isolated from adult blood samples and injected into allogeneic chick embryos. CD4+ alpha beta T cells expressing either V beta 1 or V beta 2 receptors were equally capable of inducing acute GVH reactions, consistent with the idea that alpha beta T cell alloreactivity is determined by CDR3 variability. By themselves, the gamma delta T cells were incapable of inducing GVH reactions. However, host gamma delta T cells were recruited into the donor alpha beta T cell-initiated lesions, where they were activated and induced to proliferate. The data suggest that gamma delta T cells may play a secondary role in GVH reactions.
authors.affiliation: Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham 35294-3000 USA.
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
authors.forename: D
authors.initials: D
authors.lastname: Char
authors.forename: R P
authors.initials: RP
authors.lastname: Bucy
authors.forename: M
authors.initials: M
authors.lastname: Simonsen
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.forename: M D
authors.initials: MD
authors.lastname: Cooper
mesh_terms: D000208:Acute Disease; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002453:Cell Cycle / Q000276:immunology; D002642:Chick Embryo; D002645:Chickens; D006087:Graft vs Host Reaction / Q000276:immunology*; D008213:Lymphocyte Activation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013154:Spleen / Q000166:cytology / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology / Q000276:immunology / Q000473:pathology
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta