[An experimental study of the mechanism of the combined action on the body of ionizing radiation, pesticides, nitrates and lead and cadmium salts].
The studies made showed that repeated combined action of chemical factors (pesticides of different chemical groups, Cd and Pb salts, nitrates) in the doses studied resulted in an increase of the lipid peroxidation (LPO) in tissues, accumulation of its end products in biosubstrates, and activation of catalase and peroxidase oxidoreductases in blood of test animals. Combined action of chemical factors and gamma radiation was found out to make for increasing in lipid peroxidation and involving of ceruloplasmin in the LPO inhibition. Depletion of the antioxidant system in repeated irradiations against the background of chemical loading was accompanied by accumulation of the LPO products. We conclude that in the pathogenesis of the revealed changes in associated effects of ionizing radiation, pesticides, nitrates, Plumbum and Cadmium salts, the LPO activation in the presence of the antioxidant system depletion is most important, in view of which fact the specific criteria for the studied factors combined effects on the organism appear to be the activity of the oxidation-reduction enzymes and the level of the-active products, with the chief preventive measures being directed towards increasing of radioresistance of the organism through correction of the antioxidant deficiency.
Honcharuk
Ie H
IeH
Bardov
V H
VH
Kartysh
A P
AP
Iavorovs'yĭ
Korshun
M M
MM
Verpivs'kyĭ
O M
OM
D000818:Animals; D000975:Antioxidants; D001769:Blood / Q000187:drug effects / Q000528:radiation effects; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002712:Chlorides / Q000633:toxicity*; D005720:Gamma Rays; D007854:Lead / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D009942:Organometallic Compounds / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D011830:Radiation Effects; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D002712:Chlorides; D009566:Nitrates; D009942:Organometallic Compounds; D010575:Pesticides; D002104:Cadmium; D007854:Lead; D019256:Cadmium Chloride; C008261:lead acetate