Antidepressant treatment influences cyclic AMP accumulation induced by excitatory amino acids in rat brain.
The prolonged imipramine or electroconvulsive shock treatment induced a decrease in ibotenate stimulated increase in cyclic AMP accumulation as well as it inhibited the synergistic interaction between ibotenate and noradrenaline; the glutamate-mediated inhibition of forskolin-stimulated cyclic AMP accumulation was not modified. Our results indicate that certain subtypes of metabotropic glutamate receptor are differently modified by prolonged antidepressant treatment.
Pilc
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Legutko
B
B
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D004597:Electroshock; D018846:Excitatory Amino Acids / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000928:Antidepressive Agents; D018846:Excitatory Amino Acids; D000242:Cyclic AMP; D007099:Imipramine; D009638:Norepinephrine