A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation.
A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A, -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.
Barnardo
M C
MC
Nuffield Department of Surgery, Oxford Transplant Centre, Churchill Hospital, UK.
Davey
N J
NJ
Bunce
M
M
Brookes
P A
PA
Lechler
R I
RI
Welsh
K I
KI
Batchelor
J R
JR
D016026:Bone Marrow Transplantation / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005805:Genes, MHC Class I; D015236:HLA-C Antigens / Q000032:analysis* / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007526:Isoelectric Point; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D015236:HLA-C Antigens