title: Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats.
abstract: The effect of human hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes was investigated. A human hepatocyte growth factor (360 micrograms/kg BW) was administered intravenously every 24 hr for 5 days following hepatocyte transplantation in rats. A significant increase in hepatocyte proliferation was observed morphologically and immunohistochemically (p < 0.05). The bromodexyuridine labeling index was significantly greater in human hepatocyte growth factor treated rats than in the control rats (p < 0.05). Hepatocyte growth factor may promote the proliferation of intrasplenically transplanted hepatocytes.
authors.affiliation: Second Department of Surgery, Asahikawa Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Onodera
authors.forename: M
authors.initials: M
authors.lastname: Sawa
authors.forename: M
authors.initials: M
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Kawahara
authors.forename: S
authors.initials: S
authors.lastname: Kasai
authors.forename: M
authors.initials: M
authors.lastname: Mito
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration / Q000187:drug effects; D016031:Liver Transplantation / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology*
chemical_list: D011994:Recombinant Proteins; D017228:Hepatocyte Growth Factor