Inhibition of Helicobacter pylori growth by 4-hydroxy-2-alkyl-quinolines produced by Pseudomonas aeruginosa.
4-Hydroxy-2-alkylquinolines produced by Pseudomonas aeruginosa can inhibit the growth of both metronidazole-sensitive and resistant strains of Helicobacter pylori in vitro. The MIC of one analogue, 4-hydroxy-2-heptylquinoline, was determined by agar plate incorporation as 0.1-0.5 mg/L which compares favourably with other anti-helicobacter agents.
Lacey
S L
SL
Department of Infectious Diseases and Bacteriology, Royal Postgraduate Medical School, London, UK.
Mehmet
S
S
Taylor
G W
GW
D001685:Biological Factors / Q000378:metabolism / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D011804:Quinolines / Q000378:metabolism / Q000494:pharmacology*
D001685:Biological Factors; D011804:Quinolines