title: Age-related changes in stroke risk in men with hypertension and normal blood pressure.
abstract: OBJECTIVE
  Stroke is a major contributor to total morbidity and mortality in older individuals, and hypertension is an important risk factor for stroke. Relatively few data exist on whether this relationship changes with age.
  
  
  METHODS
  To examine age-related changes in the relationships between risk of stroke and hypertension, we examined the 6-year incidence of stroke among men aged 45 to 81 years using updated blood pressure data from three examinations of Japanese-American men from the Honolulu Heart Program.
  
  
  RESULTS
  Both the prevalence of hypertension (systolic blood pressure > or = 160 mm Hg or diastolic blood pressure > or = 95 mm Hg or the use of antihypertensive medication) and the 6-year incidence of stroke increased significantly with increasing age (P < .01). The increase in thromboembolic stroke incidence with age was more marked in those who were normotensive at baseline (2.7/1000 in those aged 45 to 54 years to 23.9/1000 in those > or = 65 years; P < .001) than in hypertensive men (20.6/1000 in those aged 45 to 54 years to 33.5/1000 in those > or = 65 years; P < .01). The age-related increase in risk of thromboembolic stroke among normotensive men resulted in a decrease in the percentage of strokes attributable to hypertension (50% in those aged 45 to 54 years to 18% in those > or = 65 years; P < .05). Similar trends were seen for hemorrhagic stroke. There were no age-related changes in the relationships of other major atherosclerotic risk factors with stroke. The hypertension/stroke relationships were present after multivariate adjustment for age, smoking, cholesterol, and other factors.
  
  
  CONCLUSIONS
  In view of the greater prevalence of hypertension and the proven efficacy of treatment in the elderly, these findings do not negate the value of aggressive screening and treatment of hypertension in this age group. However, it appears that other unidentified factors have an increasing role in the causation of stroke with advancing age.
authors.affiliation: John A. Burns School of Medicine, University of Hawaii at Manoa, USA. curb@hhs.cba.hawaii.edu.
authors.forename: J D
authors.initials: JD
authors.lastname: Curb
authors.forename: R D
authors.initials: RD
authors.lastname: Abbott
authors.forename: C J
authors.initials: CJ
authors.lastname: MacLean
authors.forename: B L
authors.initials: BL
authors.lastname: Rodriguez
authors.forename: C M
authors.initials: CM
authors.lastname: Burchfiel
authors.forename: D S
authors.initials: DS
authors.lastname: Sharp
authors.forename: G W
authors.initials: GW
authors.lastname: Ross
authors.forename: K
authors.initials: K
authors.lastname: Yano
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D001281:Atrial Fibrillation; D001794:Blood Pressure; D002543:Cerebral Hemorrhage / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000401:mortality; D002784:Cholesterol / Q000097:blood; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015994:Incidence; D002542:Intracranial Embolism and Thrombosis / Q000453:epidemiology*; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking; D013923:Thromboembolism / Q000453:epidemiology*
chemical_list: D002784:Cholesterol