title: Three suicide attempts with moclobemide.
abstract: OBJECTIVE
  To report plasma moclobemide, course and outcome of two cases of overdose with moclobemide alone and one case of combined ingestion of moclobemide and clomipramide.
  
  
  METHODS
  Moclobemide identification and quantification was achieved by gas chromatography-mass spectrometry after alkaline extraction.
  
  
  METHODS
  In case 1, plasma moclobemide was 2.8 mg/L with 1.8 mg/L clomipramide; in case 2, 18 mg/L; in case 3 60.9 mg/L and 4.6 mg/L 12 hours later. None of the patients showed serious effects during 24 hours of observation. Plasma moclobemide at 10 to 30 times therapeutic was not associated with major toxic effects. Moclobemide seems to be considerably less toxic than tricyclic antidepressants.
authors.affiliation: University of Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Iwersen
authors.forename: A
authors.initials: A
authors.lastname: Schmoldt
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D001549:Benzamides / Q000097:blood / Q000506:poisoning*; D002997:Clomipramine / Q000506:poisoning; D004347:Drug Interactions; D062787:Drug Overdose; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008875:Middle Aged; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000097:blood / Q000506:poisoning*; D013406:Suicide, Attempted
chemical_list: D000929:Antidepressive Agents, Tricyclic; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D002997:Clomipramine; D020912:Moclobemide