Synthesis of a glycopeptide carrying a N-linked core pentasaccharide.
A glycopeptide carrying a pentasaccharide core structure of asparagine-linked glycoproteins was synthesized. The synthesis of the carbohydrate part was performed starting from monosaccharide components in an unambiguous manner. The resultant pentaglycosyl azide was reduced into corresponding glycosyl amine and coupled with an aspartic acid derivative to furnish an Asn-linked oligosaccharide in a protected form. Subsequent coupling with a dipeptide, followed by deprotection gave the target compound.
Matsuo
I
I
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Nakahara
Y
Y
Ito
Y
Y
Nukada
T
T
Nakahara
Y
Y
Ogawa
T
T
D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D006020:Glycopeptides / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D009844:Oligosaccharides
D006020:Glycopeptides; D009844:Oligosaccharides