title: Teething and acute graft vs. host disease: a clinical observation.
abstract: A 5-month-old girl, treated with bone marrow transplantation for severe combined immunodeficiency, developed two episodes of severe acute graft vs. host disease (GVHD) while teething. A dramatic improvement in GVHD was noted after the completion of tooth eruption. It is suggested that the release of interleukin-1, associated with the traumatized gingival tissue, is the triggering mediator for the GVHD.
authors.affiliation: Department of Pediatric Dentistry, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Shapira
authors.forename: M
authors.initials: M
authors.lastname: Aker
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.forename: R
authors.initials: R
authors.lastname: Or
authors.forename: J
authors.initials: J
authors.lastname: Kapelushnik
mesh_terms: D000208:Acute Disease; D016026:Bone Marrow Transplantation; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005881:Gingiva / Q000276:immunology / Q000293:injuries / Q000378:metabolism; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007375:Interleukin-1 / Q000096:biosynthesis*; D016511:Severe Combined Immunodeficiency / Q000628:therapy; D014078:Tooth Eruption / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents; D007375:Interleukin-1; D016572:Cyclosporine