Microsatellite instability and a TGF beta receptor: clues to a growth control pathway.
Defects of growth inhibitory pathways have an important role in disorders of cell growth and differentiation. The discovery of a mutation in one of the principle components of the transforming growth factor beta (TGF beta) receptor system which is linked to a DNA repair defect(1) represents one possible mechanism of escape from negative regulatory influences acting upon cells. TGF beta is a pre-eminent negative growth factor and this article discusses (1) the role of TGF beta in maintaining epithelial homeostasis; (2) how breakdown of inhibitory pathways can promote neoplastic development; (3) the significance of a receptor defect in a negative signalling pathway; and (4) the potential therapeutic sequelae resulting from restoration of cellular responsiveness to TGF beta.
Benson
J R
JR
Hartwell Laboratory, Institute of Cancer Research, London, UK.
Wells
K
K
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D005820:Genetic Testing; D015316:Genetic Therapy; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology*
D018125:Receptors, Transforming Growth Factor beta