Effects of cerebroventricle administration of acidic fibroblast growth factor on conditioned taste aversion learning in rats.
Wistar strain rats were given acidic fibroblast growth factor (aFGF) or denatured aFGF into their cerebroventricle before taste aversion conditioning for saccharin solution. Animals administered with aFGF showed significantly lower aversion threshold for saccharin at the 1st day and preference ratios for saccharin vs distilled water at the 4th, 6th, and 7th day after the conditioning than those administered with denatured aFGF. These results suggests that aFGF in the cerebrospinal fluid facilitates acquisition of the conditioned taste aversion learning.
Ninomiya
Y
Y
Department of Oral Physiology, Asahi University School of Dentistry, Hozumi-cho, Motosu-gun, Japan.
Nomura
T
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007278:Injections, Spinal; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013647:Task Performance and Analysis
D005346:Fibroblast Growth Factors