title: Development and validation of a Bayesian model for perioperative cardiac risk assessment in a cohort of 1,081 vascular surgical candidates.
abstract: OBJECTIVE
  This study sought to develop and validate a Bayesian risk prediction model for vascular surgery candidates.
  
  
  BACKGROUND
  Patients who require surgical treatment of peripheral vascular disease are at increased risk of perioperative cardiac morbidity and mortality. Existing prediction models tend to underestimate risk in vascular surgery candidates.
  
  
  METHODS
  The cohort comprised 1,081 consecutive vascular surgery candidates at five medical centers. Of these, 567 patients from two centers ("training" set) were used to develop the model, and 514 patients from three centers were used to validate it ("validation" set). Risk scores were developed using logistic regression for clinical variables: advanced age (>70 years), angina, history of myocardial infarction, diabetes mellitus, history of congestive heart failure and prior coronary revascularization. A second model was developed from dipyridamole-thallium predictors of myocardial infarction (i.e., fixed and reversible myocardial defects and ST changes). Model performance was assessed by comparing observed event rates with risk estimates and by performing receiver-operating characteristic curve (ROC) analysis.
  
  
  RESULTS
  The postoperative cardiac event rate was 8% for both sets. Prognostic accuracy (i.e., ROC area) was 74 +/- 3% (mean +/- SD) for the clinical and 81 +/- 3% for the clinical and dipyridamole-thallium models. Among the validation sets, areas were 74 +/- 9%, 72 +/- 7% and 76 +/- 5% for each center. Observed and estimated rates were comparable for both sets. By the clinical model, the observed rates were 3%, 8% and 18% for patients classified as low, moderate and high risk by clinical factors (p<0.0001). The addition of dipyridamole-thallium data reclassified >80% of the moderate risk patients into low (3%) and high (19%) risk categories (p<0.0001) but provided no stratification for patients classified as low or high risk according to the clinical model.
  
  
  CONCLUSIONS
  Simple clinical markers, weighted according to prognostic impact, will reliably stratify risk in vascular surgery candidates referred for dipyridamole-thallium testing, thus obviating the need for the more expensive testing. Our prediction model retains its prognostic accuracy when applied to the validation sets and can reliably estimate risk in this group.
authors.affiliation: Vascular Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: L'Italien
authors.forename: S D
authors.initials: SD
authors.lastname: Paul
authors.forename: R C
authors.initials: RC
authors.lastname: Hendel
authors.forename: J A
authors.initials: JA
authors.lastname: Leppo
authors.forename: M C
authors.initials: MC
authors.lastname: Cohen
authors.forename: L A
authors.initials: LA
authors.lastname: Fleisher
authors.forename: K A
authors.initials: KA
authors.lastname: Brown
authors.forename: S W
authors.initials: SW
authors.lastname: Zarich
authors.forename: R P
authors.initials: RP
authors.lastname: Cambria
authors.forename: B S
authors.initials: BS
authors.lastname: Cutler
authors.forename: K A
authors.initials: KA
authors.lastname: Eagle
mesh_terms: D000368:Aged; D001499:Bayes Theorem; D015331:Cohort Studies; D004176:Dipyridamole; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D015233:Models, Statistical; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D014652:Vascular Diseases / Q000601:surgery*; D014665:Vasodilator Agents
chemical_list: D013794:Thallium Radioisotopes; D014665:Vasodilator Agents; D004176:Dipyridamole