title: Simultaneous presence of t(11;14) and a variant Burkitt's translocation in the terminal phase of a mantle cell lymphoma.
abstract: Little is known about the clinical significance of secondary chromosome aberrations in lymphomas with t(11;14)(q13;q32), the characteristic change of mantle cell lymphomas. Here we present a patient with mantle cell lymphoma, who showed a variant Burkitt's translocation t(2;8)(p12;q24) in addition to t(11;14) during the progression of the disease. An involvement of chromosome 8q24, the localization of the c-myc gene, has so far been described in only four patients, who seemed to have a fatal clinical course. Although no blastic transformation occurred in our patient, no remission could be induce by intensified treatment and survival was only 5 months. This case demonstrates that secondary chromosome aberrations can determine the clinical course of patients, even if morphologic and immunophenotypic findings fail to predict the poor outcome.
authors.affiliation: Department of Hematology/Oncology, Evangelic Hospital Essen-Werden, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Tirier
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Plendl
authors.forename: K
authors.initials: K
authors.lastname: Weber-Matthiesen
authors.forename: W
authors.initials: W
authors.lastname: Langer
authors.forename: W
authors.initials: W
authors.lastname: Heit
authors.forename: B
authors.initials: B
authors.lastname: Schlegelberger
mesh_terms: D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011379:Prognosis; D014178:Translocation, Genetic