Some pharmacological properties and cumulative, subchronic and chronic toxicity of 9-methyl-2-[3-(4-phenyl-1-piperazinylpropyl)] -1,2,3,4-tetrahydro-beta-carbolin-1-one (B-193).
The cumulative, subchronic and chronic toxicity of B-193 were studied on the rats and mice. It was found that this compound exerted weak tendency to cumulation in the body. Only the highest doses of B-193 (70, 40 mg/kg po for 12 weeks) caused the increase of animals mortality. Studies on subchronic and chronic toxicity have demonstrated, that B-193 administrated po or ip for 3 weeks, and po for 12 weeks, in general, neither affects the body weight gain nor the mass and morphology of heart, liver and kidneys, as well as spontaneous locomotor activity of animals. The weak depressant effect of B-193 on peripheral blood morphology was seen only after 3 weeks po or ip treatment with this compound. The moderate effect of B-193 on activity of alanine and aspartate transaminases (A1At and AspAt) and serum protein level found after 3 weeks of treatment, was no longer observed after 12 weeks of treatment. This could indicate that above effects of B-193 are reversible.
Sieklucka-Dziuba
M
M
Department of Pharmacology, Medical Academy, Lublin, Poland.
Rajtar
G
G
Kleinrok
Z
Z
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002243:Carbolines / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010879:Piperazines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000633:toxicity*; D013997:Time Factors
D002243:Carbolines; D010879:Piperazines; D012702:Serotonin Antagonists; C062048:B 193