Effects of 5-HT3 receptor antagonists on ethanol-induced hyperlocomotion in mice.
We tested how 5-HT3 receptor antagonists, tropisetron (TR) and ondansetron (ON) affect the hyperlocomotion induced by single dose of ethanol EtOH) in mice. EtOH in a dose-dependent manner (0.5-2.0 g/kg ip) increased locomotion of mice. The effect of 2.0 g/kg of EtOH was reduced by ON (0.1 mg/kg and 1.0 mg/kg sc) and, to the lesser extent and only in limited dose range (0.01 mg/kg) by TR. Tropisetron (but not ON) increased concentrations of EtOH in the blood. The data suggest that 5-HT3 receptor is involved in EtOH-induced hyperlocomotion.
Kostowski
W
W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Sikora
J
J
Bisaga
A
A
Rosnowska
E
E
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051379:Mice; D017294:Ondansetron / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D000077526:Tropisetron
D007211:Indoles; D012702:Serotonin Antagonists; D000431:Ethanol; D017294:Ondansetron; D000077526:Tropisetron