title: Effect of various sealers with gutta-percha as root-end fillings on healing after replantation.
abstract: This study examined histologically the effect of three sealers used with gutta-percha as root-end fillings placed in a replantation model. A total of 14 molar teeth were used in seven monkeys. After extraction, root ends were resected, the canals contaminated with oral bacteria, root-end cavities prepared, and fillings of gutta-percha and sealer placed prior to replantation. After 8 weeks the teeth and surrounding jaw were removed and prepared for histological examination. Six roots filled with gutta-percha plus a fortified zinc oxide-eugenol cement (IRM), 13 with gutta-percha plus zinc oxide-eugenol (EP), and eight with gutta-percha plus Kloropercha, were available for examination. The tissue response to gutta-percha with either zinc oxide material was characterized by little or no inflammation of limited extent. In contrast, more severe inflammation was observed against root ends filled with gutta-percha and Kloropercha. Gutta-percha plus IRM or zinc oxide-eugenol had a much more favourable response than that to amalgam reported previously in a similar experiment.
authors.affiliation: Department of Conservative Dental Surgery, UMDS, Guy's Hospital, London, England.
authors.forename: T R
authors.initials: TR
authors.lastname: Pitt Ford
authors.forename: J O
authors.initials: JO
authors.lastname: Andreasen
authors.forename: S O
authors.initials: SO
authors.lastname: Dorn
authors.forename: S P
authors.initials: SP
authors.lastname: Kariyawasam
mesh_terms: D000818:Animals; D001453:Balsams / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004338:Drug Combinations; D006171:Gutta-Percha / Q000494:pharmacology; D008768:Methylmethacrylates / Q000494:pharmacology; D010485:Periapical Periodontitis / Q000139:chemically induced; D010486:Periapical Tissue / Q000187:drug effects*; D012184:Retrograde Obturation; D012387:Root Canal Filling Materials / Q000009:adverse effects / Q000494:pharmacology*; D012391:Root Resorption / Q000139:chemically induced; D014090:Tooth Replantation; D014945:Wound Healing / Q000187:drug effects*; D015034:Zinc Oxide / Q000494:pharmacology; D015035:Zinc Oxide-Eugenol Cement / Q000494:pharmacology
chemical_list: D001453:Balsams; D004338:Drug Combinations; D008768:Methylmethacrylates; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C031667:IRM cement; C029585:Kloroperka; D006171:Gutta-Percha; D015034:Zinc Oxide