title: TPA, TATI, CEA, AFP, beta-HCG, PSA, SCC, and CA 19-9 for monitoring transitional cell carcinoma of the bladder.
abstract: A total of 76 patients with transitional cell carcinoma of the bladder were prospectively monitored with simultaneous serum value estimations of tumor polypeptide antigen (TPA), tumor-associated trypsin inhibitor (TATI), carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (beta-HCG), prostatic specific antigen (PSA), squamous cell carcinoma antigen (SCC), and CA 19-9 in different stages and phases of their disease. In locally advanced disease positive values were noted for TATI in 22/28 patients (78.5%), for TPA in 17/28 (60.7%), for CA 19-9 in 10/28 (35.7%), for CEA 11/28 (39.2%), for beta-HCG in 3/28 (10.7%), for PSA in 6/28 (21.4%), for SCC in 6/28 (21.4%), and for AFP in 0/28. In metastatic disease elevated levels were observed for TATI in 43/48 patients (89.5%), for TPA in 41/48 (85.4%), for CA 19-9 in 19/48 (39.5%), for CEA in 20/48 (41.6%), for beta-HCG in 6/48 (12.5%), for PSA in 7/48 (14.5%), for SCC in 8/48 (16.6%), and for AFP in 1/48 (2.1%). In metastatic disease TATI and TPA values were significantly modified in patients with complete remission and TATI, TPA, and CA 19-9 in patients with partial remission and nonresponders. In T2-T4-N0M0 tumors, TPA, TATI, CA 19-9, and CEA were significantly increased in nonresponders. In patients with complete remission, a change in serum TATI, TPA, and CA 19-9 levels cannot be evidenced with the available numbers. The concurrent determination of TATI and TPA in T2-T4N0M0 tumors and TATI, TPA, and CA 19-9 in generalized disease could predict the response to chemotherapy. This study indicates that only the determination of TATI and TPA and in some degree the CA 19-9 is a potential tool for monitoring the efficacy of treatment.
authors.affiliation: Department of Medical Oncology, 1st Department of Medical Oncology, Metaxas Cancer Hospital, Piraeus, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Pectasides
authors.forename: D
authors.initials: D
authors.lastname: Bafaloucos
authors.forename: F
authors.initials: F
authors.lastname: Antoniou
authors.forename: L
authors.initials: L
authors.lastname: Gogou
authors.forename: N
authors.initials: N
authors.lastname: Economides
authors.forename: J
authors.initials: J
authors.lastname: Varthalitis
authors.forename: M
authors.initials: M
authors.lastname: Dimitriades
authors.forename: P
authors.initials: P
authors.lastname: Kosmidis
authors.forename: A
authors.initials: A
authors.lastname: Athanassiou
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D015843:Serpins; D019396:Tissue Polypeptide Antigen; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010455:Peptides; D015843:Serpins; D019396:Tissue Polypeptide Antigen; D000509:alpha-Fetoproteins; C051072:squamous cell carcinoma-related antigen; D014359:Trypsin Inhibitor, Kazal Pancreatic; D017430:Prostate-Specific Antigen