title: Appendiceal mucocele with concomitant colonic cancer. Report of two cases.
abstract: OBJECTIVE
  Mucocele of the appendix is an uncommon disorder, usually found incidentally during ultrasonography or radiographic studies. We report two cases of combined appendiceal mucocele and colonic cancer.
  
  
  METHODS
  The two cases were analyzed for the clinicopathologic characteristics such as history, presentation, laboratory data, radiologic and endoscopic studies, pathology, and p53 immunoreactivity.
  
  
  RESULTS
  Two patients were diagnosed with an appendiceal mucocele by ultrasound of the abdomen, together with computed tomography. Colonoscopic examination subsequently revealed synchronous colonic adenocarcinoma in both patients. Ileocecal resection following endoscopic polypectomy and a right hemicolectomy was performed for each patient. An appendiceal mucocele was histologically diagnosed as a mucinous cystadenoma. Immunohistochemical detection of abnormally high level of p53 protein was observed in colonic adenocarcinomas of both patients, whereas both appendiceal cystadenomas were negative for p53.
  
  
  CONCLUSIONS
  To be remembered is the high frequency of concomitant gastrointestinal tumors in patients with appendiceal mucocele, especially caused by mucinous neoplasms. A total colonoscopic surveillance will afford earlier diagnosis of synchronous colonic cancers in these patients.
authors.affiliation: First Department of Surgery, Okayama University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: A
authors.initials: A
authors.lastname: Hizuta
authors.forename: H
authors.initials: H
authors.lastname: Iwagaki
authors.forename: T
authors.initials: T
authors.lastname: Matsuno
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Orita
mesh_terms: D000230:Adenocarcinoma; D000368:Aged; D001063:Appendiceal Neoplasms; D003110:Colonic Neoplasms; D018291:Cystadenoma, Mucinous; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009078:Mucocele; D009378:Neoplasms, Multiple Primary