Identification of the telomeres on Schistosoma mansoni chromosomes by FISH.
The telomeres (molecular termini) of chromosomes play an important role in maintaining the structural integrity of the chromosome. Using a deoxyoligomer that contains the core sequence TTAGGG, we identified by fluorescence in situ hybridization (FISH) the telomeres on all 8 pairs of Schistosoma mansoni mitotic metaphase chromosomes. Our results indicate that S. mansoni exhibits a telomere sequence typical of other species.
Hirai
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Department of Microbiology, School of Medicine, State University of New York at Buffalo 14214, USA.
LoVerde
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PT
D000818:Animals; D001483:Base Sequence; D015342:DNA Probes / Q000737:chemistry; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D012550:Schistosoma mansoni / Q000235:genetics* / Q000648:ultrastructure; D016615:Telomere / Q000235:genetics*
D015342:DNA Probes