title: Study of the stability of creatine kinase in control materials.
abstract: We examined the stability of twelve control materials from different suppliers containing creatine kinase. The stability was assessed storing preparations at 4 degrees C, 27 degrees C and 37 degrees C and periodically measuring creatine kinase catalytic concentration. The activity was significantly greater when the lyophilized material was reconstituted with water at 4 degrees C as compared to 27 degrees C and 37 degrees C. All preparations tested showed good stability at 4 degrees C over a 72 hour period. We considered the suitability of tested control materials for quality-control purposes.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Canalias
authors.forename: Y
authors.initials: Y
authors.lastname: Saco
authors.forename: F
authors.initials: F
authors.lastname: Javier Gella
mesh_terms: D002624:Chemistry, Clinical / Q000592:standards; D003402:Creatine Kinase / Q000737:chemistry* / Q000378:metabolism*; D004795:Enzyme Stability; D006801:Humans; D011786:Quality Control; D011933:Reagent Kits, Diagnostic; D012015:Reference Standards; D013696:Temperature
chemical_list: D011933:Reagent Kits, Diagnostic; D003402:Creatine Kinase