title: Focal intestinal perforation in preterm infants is an emerging disease.
abstract: In order to elicit the pathogenesis of focal intestinal perforation in preterm infants we contrasted 8 infants who developed this disease with 16 gestation-matched controls. The cases were found to have lower birthweights for gestation (median standard deviation score of -1.02 in cases versus -0.08 in controls), and more frequently had pre-existing patent ductus arteriosus and intraventricular haemorrhage (88 and 63% in cases versus 25 and 6% in controls, respectively). There were similar rates of other perinatal variables in the two groups, including indomethacin and umbilical arterial catheter use. Conditions associated with fetal or neonatal hypoxia are important antecedents for this emerging distinct clinical entity.
authors.affiliation: Department of Neonatal Medicine, Southmead Hospital, Westbury on Trym, Bristol, UK.
authors.forename: G
authors.initials: G
authors.lastname: Raghuveer
authors.forename: B
authors.initials: B
authors.lastname: Speidel
authors.forename: N
authors.initials: N
authors.lastname: Marlow
authors.forename: H
authors.initials: H
authors.lastname: Porter
mesh_terms: D016022:Case-Control Studies; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000382:microbiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007416:Intestinal Perforation / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D007813:Laparotomy; D007958:Leukocyte Count; D010976:Platelet Count; D012189:Retrospective Studies; D013212:Staphylococcus epidermidis / Q000302:isolation & purification