Selective IgA deficiency and anaphylactoid transfusion reaction: a case report.
Anaphylactoid transfusion reaction following the administration of incompatible blood products can be life threatening, but accounts for only a very small proportion of all transfusion reactions. One of the causes of anaphylactoid transfusion reaction is the reaction of patient's anti-immunoglobulin A(IgA) with plasma IgA which is usually present in transfused blood. We report a case who had anaphylactoid transfusion reactions after transfusion of only a few milliliters of packed RBC from 3 consecutive donors, in spite of compatible pretransfusion crossmatches. The patient's serum revealed IgA deficiency accompanied by high-titer anti-IgA. The family study showed that one of her sons had partial IgA deficiency accompanied by anti-IgA2. In conclusion, although selective IgA deficiency is rare in Taiwan, it may still occasionally result in severe anaphylactoid transfusion reactions.
Wei
C H
CH
Section of Medical Oncology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Lin
M
M
Hsieh
R K
RK
Tzeng
C H
CH
Liu
J H
JH
Fan
S
S
Chiou
T J
TJ
Chen
P M
PM
D000368:Aged; D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000150:complications* / Q000235:genetics; D007070:Immunoglobulin A / Q000276:immunology; D010375:Pedigree; D065227:Transfusion Reaction
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A