title: Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil.
abstract: Two cases of acute leukaemia have developed in a group of 77 patients treated with chlorambucil (Chl) because of severe juvenile chronic arthritis. The total follow-up from the beginning of Chl treatment in these patients was 560 years, indicating a highly increased risk of leukaemia. Despite favourable results, especially in patients with secondary amyloidosis, Chl should only be used in selected cases.
authors.affiliation: Rheumatism Foundation Hospital, Heinola, Finland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kauppi
authors.forename: H A
authors.initials: HA
authors.lastname: Savolainen
authors.forename: V J
authors.initials: VJ
authors.lastname: Anttila
authors.forename: H A
authors.initials: HA
authors.lastname: Isomäki
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002675:Child, Preschool; D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced*; D008297:Male
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil