The drug-drug interaction effects of haloperidol on plasma carbamazepine levels.
The metabolic interaction between carbamazepine (CBZ) and haloperidol (HP) was studied in Japanese schizophrenic patients treated with HP but not with CBZ and with both CBZ and HP. The serum CBZ concentrations in patients treated without HP were significantly decreased (p < 0.05), on average approximately 40%, as compared to those in patients treated with both CBZ and HP, whereas the serum HP concentrations in patients treated with both HP and CBZ were significantly decreased (p < 0.05), as compared to those in patients treated with HP but not with CBZ. The effect of HP, which prevents the serum CBZ level from decreasing, was shown in this study.
Iwahashi
K
K
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Miyatake
R
R
Suwaki
H
H
Hosokawa
K
K
Ichikawa
Y
Y
D000927:Anticonvulsants / Q000097:blood* / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000097:blood / Q000494:pharmacology*; D001667:Binding, Competitive; D002220:Carbamazepine / Q000097:blood* / Q000494:pharmacology*; D019389:Cytochrome P-450 CYP2D6; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism; D004347:Drug Interactions; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006220:Haloperidol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D002220:Carbamazepine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D006220:Haloperidol