title: Gabapentin associated with aggressive behavior in pediatric patients with seizures.
abstract: Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults. We report 2 children who received GBP for intractable seizures and who developed intolerable aggressive behavior requiring dose reduction or drug discontinuation. Behavioral changes should be recognized as a possible side effect of GBP, especially in mentally retarded children.
authors.affiliation: College of Pharmacy, Division of Neurology, Ohio State University, Columbus, USA.
authors.forename: K B
authors.initials: KB
authors.lastname: Tallian
authors.forename: M C
authors.initials: MC
authors.lastname: Nahata
authors.forename: W
authors.initials: W
authors.lastname: Lo
authors.forename: C Y
authors.initials: CY
authors.lastname: Tsao
mesh_terms: D000085:Acetates / Q000009:adverse effects* / Q000627:therapeutic use; D000293:Adolescent; D000367:Age Factors; D000374:Aggression / Q000187:drug effects*; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000139:chemically induced*; D003509:Cyclohexanecarboxylic Acids; D017029:Epilepsy, Complex Partial / Q000188:drug therapy / Q000523:psychology; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D008297:Male; D012640:Seizures / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin