title: Do the facts and figures warrant a 10-fold increase in the performance of carotid endarterectomy on asymptomatic patients?
abstract: The detailed results of the Asymptomatic Carotid Atherosclerosis Study (ACAS) have been published. Electrifying reports in the media suggested that 53% fewer strokes would occur if individuals with 60% or greater stenosis were submitted to endarterectomy. The burning question is whether the evidence from this trial, and those preceding it, is sufficiently compelling to persuade any or all individuals with carotid stenosis, but free of any hemisphere and retinal symptoms, to have carotid endarterectomy. Based on a variety of population samplings, it is reasonable to estimate that approximately two million people are living in North America and Europe with asymptomatic lesions comparable with those studied in the ACAS.
authors.affiliation: Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
authors.forename: H J
authors.initials: HJ
authors.lastname: Barnett
authors.forename: M
authors.initials: M
authors.lastname: Eliasziw
authors.forename: H E
authors.initials: HE
authors.lastname: Meldrum
authors.forename: D W
authors.initials: DW
authors.lastname: Taylor
mesh_terms: D016893:Carotid Stenosis / Q000503:physiopathology* / Q000601:surgery*; D016894:Endarterectomy, Carotid / Q000706:statistics & numerical data*; D006300:Health Services Misuse; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors