title: [Selected cell-mediated immunologic parameters in patients with intrinsic asthma treated with long-term corticotherapy].
abstract: Total lymphocytes number, proportions of T lymphocyte subset, nonspecific suppressor activity induced by Con A and T-lymphocytes ability for IL-2 production were assessed. Group of 46 patients with intrinsic asthma (24 females and 22 males) including 20 asthmatics treated during 5-7 years with glucocorticosteroids were studied. Control group consisted of 12 healthy persons. Statistically significant reduction of total T cells, T-suppressor and T-helper subpopulations, ability for IL-2 production and nonspecific suppressor activity was found.
authors.affiliation: Kliniki Alergologii AM w Białymstoku.
authors.forename: T
authors.initials: T
authors.lastname: Moniuszko
authors.forename: R
authors.initials: R
authors.lastname: Rutkowski
authors.forename: S
authors.initials: S
authors.lastname: Chyrek-Borowska
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007376:Interleukin-2 / Q000378:metabolism; D018655:Lymphocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D007376:Interleukin-2