title: Estimation of total creatinine clearance is unreliable in children on peritoneal dialysis.
abstract: OBJECTIVE
  To test the reliability of creatinine clearance in children on peritoneal dialysis (PD).
  
  
  METHODS
  Longitudinal, case-controlled.
  
  
  METHODS
  Routine clinic visits at the pediatric dialysis unit of the Universitätskinderklinik of Vienna.
  
  
  METHODS
  Eleven children (2-13 years, 10-55 kg) with end-stage renal disease on PD.
  
  
  METHODS
  Creatinine clearance (CCr) was determined by measuring creatinine excretion (ECr) over 24 hours in both dialysate and urine. Each child had three to five separate measurements of their CCr. At the same time we also calculated the Schwartz formula clearance from the patient's height and serum creatinine, using a modified correlate.
  
  
  METHODS
  Reliability of CCr was assessed by two approaches. First, we compared each serial measurement with the mean value for each patient and thereby assessed the "intramethodical" variability. Second, we compared each CCr with the simultaneous formula clearance and assessed the "intermethodical" disagreement.
  
  
  RESULTS
  Twenty-seven percent of the measurements of CCr were classified as unreliable based on a comparison with the mean value for each patient. Reliability was closely correlated with residual renal function (p < 0.01); only 12% of the measurements in the anuric patients were classified as unreliable (vs 31% in the patients with residual renal function). The simultaneous formula clearance was less variable than the CCr. The formula clearance had a sensitivity of 93% and a specificity of 60% for detecting unreliable values of CCr.
  
  
  CONCLUSIONS
  Estimation of total CCr is unreliable in pediatric patients on PD. A simultaneous formula clearance can be used to detect which values are unreliable.
authors.affiliation: Kinderdialyse, Universtätskinderklinik Wien, Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Aufricht
authors.forename: E
authors.initials: E
authors.lastname: Kitzmüller
authors.forename: M A
authors.initials: MA
authors.lastname: Lothaller
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Birnbacher
authors.forename: E
authors.initials: E
authors.lastname: Balzar
authors.forename: L
authors.initials: L
authors.lastname: Greenbaum
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008137:Longitudinal Studies; D008297:Male; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003404:Creatinine