title: Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease.
abstract: The levels of calpains (m-calpain and mu-calpain) in peripheral blood lymphocytes from patients with Alzheimer's disease were determined via Western blotting. The Ca-dependent proteolytic activity and the calpastatin activity were estimated using incubation with exogenous substrate. Evidence was obtained for an increased Ca-dependent proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease. There was also an increased level of membrane-bound mu-calpain in this group of patients. The observed changes may be caused by a general dysregulation of Ca homeostasis in peripheral cells of early onset Alzheimer victims.
authors.affiliation: Department of Anatomy and Cell Biology, Göteborg University, Sweden.
authors.forename: J O
authors.initials: JO
authors.lastname: Karlsson
authors.forename: K
authors.initials: K
authors.lastname: Blennow
authors.forename: I
authors.initials: I
authors.lastname: Janson
authors.forename: K
authors.initials: K
authors.lastname: Blomgren
authors.forename: I
authors.initials: I
authors.lastname: Karlsson
authors.forename: B
authors.initials: B
authors.lastname: Regland
authors.forename: A
authors.initials: A
authors.lastname: Wallin
authors.forename: C G
authors.initials: CG
authors.lastname: Gottfries
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002154:Calpain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D002135:Calcium-Binding Proteins; C033668:calpastatin; D002154:Calpain; D002118:Calcium