title: Cardiac troponin I release correlates with myocardial infarction size.
abstract: Cardiac troponin I, creatine kinase, and creatine kinase MB activity were tested in serial blood samples from 15 patients with first-time Q wave acute myocardial infarction (2 anterior and 13 inferior wall infarctions). All patients received intravenous thrombolytic therapy. Cardiac troponin I and creatine kinase MB activity were compared with scintigraphic estimates of myocardial scar (single photon emission computed tomography [SPECT] with 99mTechnetium-isonitrile [Tc-sestamibi]) on late images at rest about 5 weeks after myocardial infarction. Scintigraphic defect sizes ranged from 3.2 to 41.2% (median: 27.3%) of left ventricle. Cardiac troponin I increased and peaked in parallel with creatine kinase MB activity, and the peak values correlated with each other (r = 0.76, p = 0.002). Troponin I stayed increased for several days longer than creatine kinase and creatine kinase MB activity. It could be detected at least until the 4th day after admission. Significant correlation coefficients were found between 99mTc-isonitrile defect sizes and areas under cardiac troponin I curves (r = 0.53, p = 0.042) and between 99mTc-isonitrile defect sizes and cumulative creatine kinase MB activity release (r = 0.64, p = 0.01). Animal studies have already shown a very close correlation between histologic infarct size and SPECT 99mTc-isonitrile defect size. Therefore, our results indicate that cardiac troponin I release in patients with acute myocardial infarction is also correlated with infarct size.
authors.affiliation: Institut für Medizinische Chemie & Biochemie, Universität Innsbruck, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Mair
authors.forename: I
authors.initials: I
authors.lastname: Wagner
authors.forename: B
authors.initials: B
authors.lastname: Morass
authors.forename: L
authors.initials: L
authors.lastname: Fridrich
authors.forename: P
authors.initials: P
authors.lastname: Lechleitner
authors.forename: F
authors.initials: F
authors.lastname: Dienstl
authors.forename: C
authors.initials: C
authors.lastname: Calzolari
authors.forename: C
authors.initials: C
authors.lastname: Larue
authors.forename: B
authors.initials: B
authors.lastname: Puschendorf
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology; D011446:Prospective Studies; D017256:Technetium Tc 99m Sestamibi; D015912:Thrombolytic Therapy; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D014336:Troponin / Q000097:blood*; D019210:Troponin I
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D014336:Troponin; D019210:Troponin I; D017256:Technetium Tc 99m Sestamibi; D003402:Creatine Kinase