title: In vivo He-3 MR images of guinea pig lungs.
abstract: The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.
authors.affiliation: Center for in Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Black
authors.forename: H L
authors.initials: HL
authors.lastname: Middleton
authors.forename: G D
authors.initials: GD
authors.lastname: Cates
authors.forename: G P
authors.initials: GP
authors.lastname: Cofer
authors.forename: B
authors.initials: B
authors.lastname: Driehuys
authors.forename: W
authors.initials: W
authors.lastname: Happer
authors.forename: L W
authors.initials: LW
authors.lastname: Hedlund
authors.forename: G A
authors.initials: GA
authors.lastname: Johnson
authors.forename: M D
authors.initials: MD
authors.lastname: Shattuck
authors.forename: J C
authors.initials: JC
authors.lastname: Swartz
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006371:Helium; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D011868:Radioisotopes
chemical_list: D011868:Radioisotopes; D006371:Helium