title: Impaired small intestinal peristaltic reflexes and sensory thresholds are independent functional disturbances in patients with chronic unexplained dyspepsia.
abstract: OBJECTIVE
  To study disturbances of gastrointestinal motility and afferent (sensory) dysfunction in functional (unexplained) dyspepsia, and the interrelationships between motility and sensory dysfunction.
  
  
  METHODS
  Twelve patients with functional dyspepsia and 12 controls matched for age and gender were studied. Intestinal perception thresholds were tested by a standardized stepwise distension procedure in the third portion of the duodenum with a barostat device. Small intestinal motility was measured with a low compliance perfusion system proximal and distal to the distending balloon.
  
  
  RESULTS
  First perception of duodenal balloon distension occurred at significantly (p <0.01) lower pressures in patients (23 +/- 3 mm Hg, mean +/- SEM) than in healthy controls (31 +/- 3 mm Hg). Patients had a lower maximal intestinal pain tolerance than controls (31 +/- 2 mm Hg vs. 39 +/- 1 mm Hg, p <0.05). Duodenal distension inhibited intestinal motility distal to the distending balloon (peristaltic reflex) more often in health controls (11/12) than in patients with functional dyspepsia (5/12, p <0.05). These alterations of small intestinal motility occurred at pressure values below the perception thresholds, and disturbed motility responses were not associated with perception thresholds.
  
  
  CONCLUSIONS
  Disturbed peristaltic reflexes and decreased sensory thresholds for perception of intestinal sensations are prevalent but may be independent abnormalities in patients with unexplained dyspepsia.
authors.affiliation: Division of Gastroenterology, University of Essen. Germany.
authors.forename: G
authors.initials: G
authors.lastname: Holtmann
authors.forename: H
authors.initials: H
authors.lastname: Goebell
authors.forename: J
authors.initials: J
authors.lastname: Talley
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002908:Chronic Disease; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000503:physiopathology*; D008297:Male; D010528:Peristalsis / Q000502:physiology*; D012018:Reflex / Q000502:physiology; D012684:Sensory Thresholds