title: The Nigerian I/CDC strain of Plasmodium ovale in chimpanzees.
abstract: The chimpanzee is the only animal host currently available that can support the development of the human malaria parasite Plasmodium ovale. Thirty-one infections with the Nigerian I/CDC strain were induced in splenectomized chimpanzees. Maximum parasite counts ranged from 1,240 to 127,224/microliters. Infections were transient and unpredictable. Anopheles stephensi, Anopheles gambiae, Anopheles freeborni, and Anopheles dirus mosquitoes were infected by feeding through parafilm membranes on heparinized blood containing gametocytes; each species supported development to sporozoites in the salivary glands. Mean oocyst counts per infected mosquito ranged from 1 to 85.1; 21.7% of infected lots of mosquitoes averaged > 20 oocysts per positive mosquito gut. One infection was induced via the bites of infected An. gambiae. The prepatent period was 16 days.
authors.affiliation: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Morris
authors.forename: J S
authors.initials: JS
authors.lastname: Sullivan
authors.forename: H M
authors.initials: HM
authors.lastname: McClure
authors.forename: E
authors.initials: E
authors.lastname: Strobert
authors.forename: B B
authors.initials: BB
authors.lastname: Richardson
authors.forename: G G
authors.initials: GG
authors.lastname: Galland
authors.forename: I F
authors.initials: IF
authors.lastname: Goldman
authors.forename: W E
authors.initials: WE
authors.lastname: Collins
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D018420:Ape Diseases / Q000276:immunology / Q000469:parasitology*; D007303:Insect Vectors / Q000469:parasitology; D008288:Malaria / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D009549:Nigeria; D002679:Pan troglodytes / Q000469:parasitology*; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology / Q000662:veterinary; D010961:Plasmodium / Q000276:immunology / Q000502:physiology*; D013156:Splenectomy / Q000662:veterinary