title: Pain palliation with strontium-89 in children with metastatic disease.
abstract: We report two cases of children with metastatic bone disease who received strontium-89 intravenously. An 11-year-old boy with stage IV neuroblastoma received 50 microCi/kg of strontium-89. He had a good response, and his pain abated to the point that he could be taken off IV Dilaudid and was discharged from the hospital. A 7-year-old girl with the diagnosis of squamous cell carcinoma of the lung disclosed minimal increased uptake on a bone scan. Following the strontium-89 therapy, she did not have any significant improvement in pain, probably due to the minimal osteoblastic activity evidenced by the minimal abnormalities on the bone scan. Until this report there has been no reported case of using strontium-89 in the treatment of children with metastatic disease.
authors.affiliation: Department of Radiology, Children's Hospital of Pittsburgh, Pennsylavania 15213, USA.
authors.forename: M
authors.initials: M
authors.lastname: Charron
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: P
authors.initials: P
authors.lastname: Rowland
authors.forename: J
authors.initials: J
authors.lastname: Mirro
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary*; D002648:Child; D016371:Cranial Irradiation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000627:therapeutic use; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary*; D010006:Osteoblasts / Q000528:radiation effects; D010146:Pain / Q000517:prevention & control*; D010166:Palliative Care; D010351:Patient Discharge; D012074:Remission Induction; D013116:Spinal Cord / Q000528:radiation effects; D013326:Strontium Radioisotopes / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D013326:Strontium Radioisotopes; D004091:Hydromorphone