title: Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain.
abstract: 5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.
authors.affiliation: Sandoz Pharma Ltd., Basel, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Fehr
authors.forename: J J
authors.initials: JJ
authors.lastname: Sanglier
authors.forename: W
authors.initials: W
authors.lastname: Schuler
authors.forename: L
authors.initials: L
authors.lastname: Gschwind
authors.forename: M
authors.initials: M
authors.lastname: Ponelle
authors.forename: W
authors.initials: W
authors.lastname: Schilling
authors.forename: C
authors.initials: C
authors.lastname: Wioland
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors; D002352:Carrier Proteins / Q000378:metabolism*; D002417:Cattle; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora / Q000378:metabolism*; D015394:Molecular Structure; D011090:Polyenes / Q000037:antagonists & inhibitors / Q000494:pharmacology; D020123:Sirolimus; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D022021:Tacrolimus Binding Proteins
chemical_list: D000900:Anti-Bacterial Agents; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007166:Immunosuppressive Agents; D011090:Polyenes; C099294:antascomicin A; C099295:antascomicin B; C099296:antascomicin C; C099297:antascomicin D; C099298:antascomicin E; D022021:Tacrolimus Binding Proteins; D020123:Sirolimus; D016559:Tacrolimus