title: Autoimmune hepatitis in a patient with sickle cell disease.
abstract: In this report, we describe the case of a 28-yr-old woman with sickle cell anemia who presented with acute hepatic failure manifested by anorexia, malaise, painless jaundice, elevated aminotransferase activities, and severe coagulopathy. Liver biopsy revealed changes consistent with autoimmune hepatitis. Treatment with corticosteroids and azathioprine was followed by improvement in biochemical liver test results. The literature on sickle cell-associated liver diseases is reviewed.
authors.affiliation: Department of Medicine, Mount Sinai Medical Center, New York, New York, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: el Younis
authors.forename: A D
authors.initials: AD
authors.lastname: Min
authors.forename: M I
authors.initials: MI
authors.lastname: Fiel
authors.forename: F M
authors.initials: FM
authors.lastname: Klion
authors.forename: S N
authors.initials: SN
authors.lastname: Thung
authors.forename: B
authors.initials: B
authors.lastname: Faire
authors.forename: C M
authors.initials: CM
authors.lastname: Miller
authors.forename: H C
authors.initials: HC
authors.lastname: Bodenheimer
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D006505:Hepatitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D001379:Azathioprine