title: A randomized, double-blind, placebo-controlled study of the safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis 55455, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Zimmerman
authors.forename: K
authors.initials: K
authors.lastname: Duderstadt
authors.forename: J
authors.initials: J
authors.lastname: Chambers
authors.forename: A L
authors.initials: AL
authors.lastname: Sorenson
authors.forename: D K
authors.initials: DK
authors.lastname: Granger
authors.forename: P S
authors.initials: PS
authors.lastname: Almond
authors.forename: J p
authors.initials: Jp
authors.lastname: Fryer
authors.forename: J R
authors.initials: JR
authors.lastname: Leventhal
authors.forename: J
authors.initials: J
authors.lastname: Scarola
authors.forename: A J
authors.initials: AJ
authors.lastname: Matas
authors.forename: D M
authors.initials: DM
authors.lastname: Canafax
mesh_terms: D000284:Administration, Oral; D016572:Cyclosporine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006261:Headache; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010919:Placebos; D011090:Polyenes / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D020123:Sirolimus
chemical_list: D007166:Immunosuppressive Agents; D010919:Placebos; D011090:Polyenes; D016572:Cyclosporine; D020123:Sirolimus