title: An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrid.
abstract: Interspecific hybridization between closely related species is commonly associated with decreased fertility or viability of F1 hybrids. Thus, in mouse interspecific hybrids, several different hybrid sterility genes that impair gametogenesis of the male hybrids have been described. We describe a novel effect in hybrids between different mouse species that manifests itself in abnormal growth of the placenta. Opposite phenotypes, that is, placental hypotrophy versus hypertrophy, are observed in reciprocal crosses and backcrosses. The severity of the phenotype, which is mainly caused by abnormal development of the spongiotrophoblast, is influenced by the sex of the conceptus. In general, placental hypertrophy is associated with increased fetal growth. Hypotrophy of the placenta frequently leads to growth impairment or death of the fetus. One of the major genetic determinants of placental growth maps to the proximal part of the mouse X chromosome.
authors.affiliation: Abteilung Medizinische Genetik der Universität Ulm, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Zechner
authors.forename: M
authors.initials: M
authors.lastname: Reule
authors.forename: A
authors.initials: A
authors.lastname: Orth
authors.forename: F
authors.initials: F
authors.lastname: Bonhomme
authors.forename: B
authors.initials: B
authors.lastname: Strack
authors.lastname: Guénet
authors.forename: H
authors.initials: H
authors.lastname: Hameister
authors.forename: R
authors.initials: R
authors.lastname: Fundele
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005298:Fertility / Q000235:genetics; D008040:Genetic Linkage; D008297:Male; D009115:Muridae; D009929:Organ Size; D010641:Phenotype; D010920:Placenta / Q000002:abnormalities* / Q000473:pathology; D011247:Pregnancy; D012727:Sex Characteristics; D013045:Species Specificity; D014960:X Chromosome