title: Increase in activin beta A mRNA in rat hippocampus during long-term potentiation.
abstract: We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin beta A subunit. Convulsive seizure caused by kainate significantly induced the expression of activin beta A mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (>10 h), caused a marked increase at 3 h in the level of activin beta A mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin alpha mRNA was not changed following the induction of LTP. THe results suggest a role for activin in maintenance of neural plasticity in the adult brain.
authors.affiliation: Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Inokuchi
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Hiraia
authors.forename: F
authors.initials: F
authors.lastname: Hishinuma
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: F
authors.initials: F
authors.lastname: Ozawa
mesh_terms: D028341:Activins; D000818:Animals; D001483:Base Sequence; D003292:Convulsants / Q000494:pharmacology; D018891:Dentate Gyrus / Q000502:physiology; D004558:Electric Stimulation; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007265:Inhibins / Q000235:genetics*; D007608:Kainic Acid / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D010433:Pentylenetetrazole / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012640:Seizures / Q000139:chemically induced
chemical_list: D003292:Convulsants; D018690:Excitatory Amino Acid Agonists; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D028341:Activins; D007265:Inhibins; D007608:Kainic Acid; D010433:Pentylenetetrazole