Mixed gonadal dysgenesis with gonadoblastoma in a female with Y chromosome: case report.
A young female with primary amenorrhea and male karyotype (46/XY) is reported. Physical examination and clinical investigation of the patient suggested mixed gonadal dysgenesis (MGD). After gonadectomy, a tumor was found on the left side and histologically diagnosed gonadoblastoma. Postoperative decreased level of testosterone and estradiol reflected the activities of the tumor.
Sadi
A M
AM
Department of Clinical Laboratory Medicine, School of Medicine, University of The Ryukyus, Okinawa, Japan.
Toda
T
T
Kiyuna
M
M
Miyagi
H
H
D000568:Amenorrhea / Q000235:genetics; D005260:Female; D006060:Gonadal Dysgenesis, Mixed / Q000150:complications* / Q000473:pathology; D018238:Gonadoblastoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology