The effect of reduced glutathione (TAD-600) on the behavior of rats neonatally intoxicated with ethanol.
The study was performed on three groups of male rats of the Wistar strain at the age of three months: group 1 (n = 10), the control group; group 2 (n = 10), consisting of animals treated neonatally (from day 4 through day 10) with ethanol 20%, administered by gavage to the mothers, at the dose of 5 g/kg body/day; group 3 (n = 10) of animals exposed to ethanol under similar conditions, but whose mothers have been injected a reduced glutathione (TAD-600) solution in a dose of 2 mg/100 g body weight of the mother. All the animals were weight ed before the test of behavior. The neonatal administration of ethanol caused ponderal weight retardation, which was not influenced by TAD-600 administrations. Also, a decrease in the scores of emotivity and spontaneous motility in the open field was noticed, as well as difficulties in the acquisition of active avoidance conditioned reflexes in the shuttle-box. Concomitant glutathione administration during the neonatal period significantly improves the learning ability at the age of three months, as well as the score of emotivity, without improving the spontaneous motility score.
Lupu
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Physiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca.
Dorofteiu
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M
D000818:Animals; D000831:Animals, Newborn; D000931:Antidotes / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D000431:Ethanol / Q000506:poisoning*; D005978:Glutathione / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
D000931:Antidotes; D000431:Ethanol; D005978:Glutathione