[The mutagenic and modifying properties of emoxipin studied by micronucleus assay in liver cells].
Emoxypin is a medicinal drug from the group of 3-oxypyridines. We studied the capacity of emoxypin to affect the spontaneous level of micronuclear aberrations in the hepatocytes (to decrease or increase it by exerting a mutagenic effect) using the micronucleus test, as well as the capacity to modulate (enhance or weaken) the effects of nitrosomethylurea and X-irradiation. The results obtained do not suggest cytogenetic activity of emoxypin. The nature of "spontaneous" micronuclear aberrations in the liver are discussed, as well as the causes of their age-related increase and adequacy of this model to search for antimutagens.
Uryvaeva
I V
IV
Delone
G V
GV
Smirnov
L D
LD
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000528:radiation effects / Q000648:ultrastructure; D008770:Methylnitrosourea / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D009153:Mutagens / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology*; D013997:Time Factors
D000975:Antioxidants; D009153:Mutagens; D010847:Picolines; D008770:Methylnitrosourea; C009820:6-methyl-2-ethyl-3-hydroxypyridine