title: New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation.
abstract: New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.
authors.affiliation: Instituto de Química Médica (CSIC), Madrid, Spain.
authors.forename: A I
authors.initials: AI
authors.lastname: Esteban
authors.forename: O
authors.initials: O
authors.lastname: Juanes
authors.forename: S
authors.initials: S
authors.lastname: Conde
authors.forename: P
authors.initials: P
authors.lastname: Goya
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: A
authors.initials: A
authors.lastname: Martínez
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D013829:Thiadiazines / Q000138:chemical synthesis*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D013829:Thiadiazines