title: Penetration of topical 0.3% ciprofloxacin into human aqueous humor.
abstract: OBJECTIVE
  Investigation of the penetration of topical ciprofloxacin into aqueous humor.
  
  
  METHODS
  Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection.
  
  
  RESULTS
  Mean aqueous concentration was 0.83+/-0.48 microgram/ml in group A and 2.42+/-1.42 micrograms/ml in group B.
  
  
  CONCLUSIONS
  Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.
authors.affiliation: Department of Ophthalmology, Numune State Research and Training Hospital, Ankara, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Kalayci
authors.forename: N
authors.initials: N
authors.lastname: Basci
authors.forename: E
authors.initials: E
authors.lastname: Akpek
authors.forename: H
authors.initials: H
authors.lastname: Hasiripi
authors.forename: A
authors.initials: A
authors.lastname: Bozkurt
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008875:Middle Aged; D009994:Osmolar Concentration; D011292:Premedication
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin