cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog.
In Drosophila, it has been shown that protein kinase A and hedgehog have antagonistic actions during the formation of imaginal disks. In vertebrate skin, sonic hedgehog is expressed specifically in the feather bud epithelia. using an in vitro explant culture model we showed that dibutyryl cAMP, a protein kinase A (PKA) activator, suppresses the expression of Sonic hedgehog, (Shh) and continuous feather growth. The results suggest that Shh and PKA also have antagonistic action during vertebrate skin morphogenesis.
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Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles 90033, USA.
Jiang
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Chuong
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CM
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002642:Chick Embryo; D005576:Colforsin / Q000494:pharmacology; D016895:Culture Media, Serum-Free; D000242:Cyclic AMP / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004330:Drosophila; D004627:Embryonic Induction; D004789:Enzyme Activation; D005241:Feathers; D015870:Gene Expression / Q000187:drug effects*; D053823:Hedgehog Proteins; D017403:In Situ Hybridization; D009024:Morphogenesis; D009924:Organ Culture Techniques; D014176:Protein Biosynthesis; D012867:Skin / Q000187:drug effects / Q000196:embryology*; D015534:Trans-Activators
D016895:Culture Media, Serum-Free; D053823:Hedgehog Proteins; D015534:Trans-Activators; D005576:Colforsin; D003994:Bucladesine; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases