Influence of plasma preparations and donor red blood cells on the antioxidant capacity of blood from newborn babies: an in vitro study.
We investigated in an in vitro transfusion model the early effects of plasma preparations and donor red blood cells on the antioxidant capacity of the cord blood from babies. Addition of pasteurized plasma protein solution to plasma from babies decreased the peroxyl radical trapping capacity (p < 0.02). In contrast, fresh frozen plasma did not lower this capacity. Addition of adult donor red blood cells to the babies' red blood cells did not significantly decrease the glutathione-recycling capacity of the blood. On the basis of these in vitro results we hypothesize that the use of resuscitation fluids with low antioxidant capacity may temporarily decrease the ability of the baby to catabolize reactive oxygen species.
Moison
R M
RM
Department of Paediatrics, University Hospital of Leiden, The Netherlands.
van Hoof
E J
EJ
Clahsen
P C
PC
van Zoeren-Grobben
D
D
Berger
H M
HM
D000328:Adult; D001782:Blood Donors; D018929:Cell Culture Techniques; D017707:Erythrocyte Transfusion; D005312:Fetal Blood; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007231:Infant, Newborn; D010949:Plasma / Q000187:drug effects / Q000502:physiology*; D013053:Spectrophotometry
D006861:Hydrogen Peroxide; D005978:Glutathione