title: Sites of failure and times to failure in carcinoma of the vulva treated conservatively: a Gynecologic Oncology Group study.
abstract: OBJECTIVE
  The objective of this review was to examine the patterns of failure after conservative therapy for vulvar carcinoma to establish a basis for the design of prospective cooperative trials in this disease.
  
  
  METHODS
  The records and characteristics of all patients in whom cancer recurred after conservative therapy in two prospective clinical trials were analyzed.
  
  
  RESULTS
  Of 143 patients who received one or more modifications of therapy, 37 patients had recurrence of cancer and 20 died of the disease. The median intervals to recurrence were 35.9 months for vulvar cancer and 7.0 months for groin cancer (p = 0.0002). There were 12 groin recurrences; 11 (91.7%) of these patients have died of the disease. The median survival time after recurrence was 52.4 months for patients with vulvar cancer and 9.4 months for those with groin cancer (p = 0.0025).
  
  
  CONCLUSIONS
  Groin cancer recurs earlier than vulvar cancer among patients treated conservatively. Future trials that evaluate modified therapy to the groin need to include early interim analyses. Follow-up for > 36 months after study entry may not be necessary to evaluate the impact of new treatments.
authors.affiliation: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: F B
authors.initials: FB
authors.lastname: Stehman
authors.forename: B N
authors.initials: BN
authors.lastname: Bundy
authors.forename: H
authors.initials: H
authors.lastname: Ball
authors.forename: D L
authors.initials: DL
authors.lastname: Clarke-Pearson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D013997:Time Factors; D017211:Treatment Failure; D014846:Vulvar Neoplasms / Q000401:mortality / Q000628:therapy*