title: Results of combined modality therapy for patients with anal cancer (E7283). An Eastern Cooperative Oncology Group study.
abstract: BACKGROUND
  This prospective study assessed combined modality therapy of patients with International Union Against Cancer classification T1-4 N0 M0 anal cancer.
  
  
  METHODS
  Protocol therapy consisted of a dose of 4000 cGy to the pelvis, anus, and perineum, followed by a 1000-1300 cGy boost. Infusions of 5-fluorouracil and mitomycin-C were administered when radiation therapy began. A second infusion of 5-fluorouracil was administered 28 days later. Biopsy was performed 6-8 weeks after completion of treatment. Positive biopsy findings resulted in abdominal-perineal resection.
  
  
  RESULTS
  Survival at 7 years for 50 eligible patients was 58%. White patients and those with favorable performance status had significantly better survival. Of the 46 patients evaluable for response, 34 had a complete response, 11 had a partial response, and 1 had no response. Seven-year survival for partial responders was 53%. Freedom from locoregional progression was 80% at 7 years.
  
  
  CONCLUSIONS
  Treatment with a combination of chemotherapy and radiation therapy is effective for patients with anal cancer. The investigation of methods of improving therapy is warranted.
authors.affiliation: Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Martenson
authors.forename: S R
authors.initials: SR
authors.lastname: Lipsitz
authors.forename: M
authors.initials: M
authors.lastname: Lefkopoulou
authors.forename: P F
authors.initials: PF
authors.lastname: Engstrom
authors.forename: Y Y
authors.initials: YY
authors.lastname: Dayal
authors.forename: C D
authors.initials: CD
authors.lastname: Cobau
authors.forename: M M
authors.initials: MM
authors.lastname: Oken
authors.forename: D G
authors.initials: DG
authors.lastname: Haller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D016685:Mitomycin; D005472:Fluorouracil