A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice.
Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of transgenic mice. Expression of two different constructs caused the development of peripheral lymphomas. The infiltrating cells were of T-cell origin, expressing mainly the CD4 phenotype and restricted sets of V beta chains. Thus, StpA is not only necessary for the oncogenicity of Herpesvirus saimiri, but is also sufficient for the induction of peripheral pleomorphic T-cell lymphomas.
Kretschmer
C
C
Pathologisches Institut, Universität Erlangen-Nürnberg, Germany.
Murphy
C
C
Biesinger
B
B
Beckers
J
J
Fickenscher
H
H
Kirchner
T
T
Fleckenstein
B
B
Rüther
U
U
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D015152:Blotting, Northern; D017252:CD3 Complex; D015704:CD4 Antigens; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D015870:Gene Expression; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics*; D007150:Immunohistochemistry; D008213:Lymphocyte Activation; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000821:virology*; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics* / Q000821:virology*; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D010641:Phenotype; D011401:Promoter Regions, Genetic; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000235:genetics
D001426:Bacterial Proteins; D017252:CD3 Complex; D015704:CD4 Antigens; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D018832:Molecular Chaperones; D009856:Oncogene Proteins, Viral; D011948:Receptors, Antigen, T-Cell; C064364:STP protein, Herpesvirus saimiri; C090104:StpA protein, E coli