title: Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.
abstract: The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.
authors.affiliation: F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors.forename: I
authors.initials: I
authors.lastname: Heinze-Krauss
authors.forename: P
authors.initials: P
authors.lastname: Angehrn
authors.forename: P
authors.initials: P
authors.lastname: Guerry
authors.forename: P
authors.initials: P
authors.lastname: Hebeisen
authors.forename: C
authors.initials: C
authors.lastname: Hubschwerlen
authors.forename: I
authors.initials: I
authors.lastname: Kompis
authors.forename: M G
authors.initials: MG
authors.lastname: Page
authors.forename: H G
authors.initials: HG
authors.lastname: Richter
authors.forename: V
authors.initials: V
authors.lastname: Runtz
authors.forename: H
authors.initials: H
authors.lastname: Stalder
authors.forename: U
authors.initials: U
authors.lastname: Weiss
authors.forename: C C
authors.initials: CC
authors.lastname: Wei
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013210:Staphylococcus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins