Granule-laden perivascular cells observed in rabbits with experimental cerebral atherosclerosis.
Granule-laden perivascular cells distributed around the fine vessels in brain of hypertensive rabbits fed a cholesterol diet were examined by electron microscopy. Perivenule granule-laden cells contained secondary lysosomes, residual bodies, Golgi vesicles, fusion vesicles, and vacuoles. In periarteriole granule-laden cells, secondary lysosomes and vacuoles were not prominent. Findings indicated that the granule-laden cell may be a histiocyte that appears during the vascular reaction to hypertension and hypercholesterolemia. This vascular reaction may occur more strongly in the veins than the arteries.
Kato
H
H
Department of Internal Medicine, Saga Medical School, Saga, Japan.
Okada
R
R
Takashima
T
T
Ohmori
K
K
Sunaga
T
T
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology*; D002536:Cerebral Arteries / Q000473:pathology* / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000473:pathology* / Q000648:ultrastructure; D006644:Histiocytes / Q000473:pathology; D002537:Intracranial Arteriosclerosis / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits