[Influence of infertility etiology and follicular stimulation protocols on pregnancy outcomes by in vitro fertilization].
During a retrospective study on 152 singles pregnancies obtained by in vitro fecondation at Tenon hospital, and followed in this department between January 1990 and December 1994, we have studied the influence of the IVF (tubal origin, masculine or idiopathic) and the type of stimulation (human menopausal gonadotrophin: hMG or follicle stimulating hormone: FSH) on the weight of the newborn and the pathologies that occurred during the pregnancy. No difference in the antecedents has been found in the different group of patients. This study shows a significative difference (p < 0.001) of the newborn's weight when the indication of IVF is tubal origin or masculine. Also, in all IVF indications, the weight is significantly (p < 0.01) higher after a follicular stimulation by FSH versus hMG. For the pregnancy pathologies, no significative difference has been noted, although arterial hypertension, fetal growth retardation and gestational diabetes appear to be more frequent in the group of women who had stimulation by hMG.
Merviel
P
P
Service de Gynécologie-Obstétrique et Fécondation in vitro, Hôpital Tenon, Paris.
Antoine
J M
JM
Alvarez
S
S
Cornet
D
D
Plachot
M
M
Mandelbaum
J
J
Uzan
S
S
Salat-Baroux
J
J
D000328:Adult; D001724:Birth Weight; D002985:Clinical Protocols; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007246:Infertility / Q000209:etiology* / Q000628:therapy*; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D005300:Fertility Agents, Female; D008596:Menotropins; D005640:Follicle Stimulating Hormone