Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats.
The effect of human hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes was investigated. A human hepatocyte growth factor (360 micrograms/kg BW) was administered intravenously every 24 hr for 5 days following hepatocyte transplantation in rats. A significant increase in hepatocyte proliferation was observed morphologically and immunohistochemically (p < 0.05). The bromodexyuridine labeling index was significantly greater in human hepatocyte growth factor treated rats than in the control rats (p < 0.05). Hepatocyte growth factor may promote the proliferation of intrasplenically transplanted hepatocytes.
Kato
K
K
Second Department of Surgery, Asahikawa Medical College, Japan.
Onodera
K
K
Sawa
M
M
Imai
M
M
Kawahara
T
T
Kasai
S
S
Mito
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration / Q000187:drug effects; D016031:Liver Transplantation / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology*
D011994:Recombinant Proteins; D017228:Hepatocyte Growth Factor