Renal collecting duct carcinoma in an 8-year-old child.
A fatal collecting duct carcinoma, presenting with pleural metastases, arose from the right kidney in an 8-year-old child. A distal nephron origin of the tumor is supported by positive tumor staining with Ulex europaeus and Arachis hypogaea, and a lack of staining with Tetragonolobus lotus. The ultrastructural features of short stubby microvilli, smooth basal cell membranes, and lateral membrane infoldings also support a distal nephron origin (inner most inner medullary collecting duct). This rare childhood renal neoplasm behaved similarly to that reported in adults with metastatic disease at presentation and a short fatal clinical course.
Craver
R D
RD
Department of Pathology, Louisiana State University School of Medicine, New Orleans, USA.
Correa
H
H
Crapanzano
J P
JP
Kumar
S R
SR
Gardner
R V
RV
D002277:Carcinoma / Q000473:pathology*; D002648:Child; D017809:Fatal Outcome; D006801:Humans; D007633:Keratins / Q000378:metabolism; D007680:Kidney Neoplasms / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D007685:Kidney Tubules, Collecting; D008297:Male; D010997:Pleural Neoplasms / Q000556:secondary
D007633:Keratins