Near-hexaploid Ph-positive acute myeloid leukemia with major-BCR/ABL transcript.
We describe the first case of acute myeloid leukemia (AML) with a Philadelphia (Ph) translocation and a near-hexaploid range chromosome number, whose leukemic cells had the major-BCR/ABL transcript. The genesis of near-hexaploid leukemic cells might be due to endoreduplication of triploid leukemic cells with the Ph, since the relapsed leukemic cells had triploid range chromosomes with double Ph chromosomes.
Iwama
H
H
First Department of Internal Medicine, Tokyo Medical College, Japan.
Ohyashiki
K
K
Ohyashiki
J H
JH
Shimamoto
T
T
Fujimura
T
T
Kawakubo
K
K
Kuriyama
Y
Y
Kodama
A
A
Toyama
K
K
D000782:Aneuploidy; D001483:Base Sequence; D015139:Blotting, Southern; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; D016044:Fusion Proteins, bcr-abl