title: Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats.
abstract: Implantation of the ascitic tumour Yoshida AH-130 hepatoma (a cachectic tumour) resulted in important increases in muscle ubiquitin gene expression. Administration of daily injections of 25 mg/kg b.w. polyclonal goat anti-murine TNF IgG preparation to tumour-bearing rats abolished the increase in muscle ubiquitin gene expression observed in the control (non-anti-TNF-treated) tumour-bearing rats. It is concluded that TNF can have an important role in the activation of the ubiquitin-dependent proteolytic system during tumour growth.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Universitat de Universitat de Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Llovera
authors.forename: N
authors.initials: N
authors.lastname: Carbó
authors.forename: C
authors.initials: C
authors.lastname: García-Martínez
authors.forename: P
authors.initials: P
authors.lastname: Costelli
authors.forename: L
authors.initials: L
authors.lastname: Tessitore
authors.forename: F M
authors.initials: FM
authors.lastname: Baccino
authors.forename: N
authors.initials: N
authors.lastname: Agell
authors.forename: G J
authors.initials: GJ
authors.lastname: Bagby
authors.forename: F J
authors.initials: FJ
authors.lastname: López-Soriano
authors.forename: J M
authors.initials: JM
authors.lastname: Argilés
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D002100:Cachexia / Q000150:complications; D003546:Cysteine Endopeptidases / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000150:complications / Q000235:genetics*; D008297:Male; D009097:Multienzyme Complexes / Q000235:genetics; D018482:Muscle, Skeletal / Q000378:metabolism*; D009368:Neoplasm Transplantation; D046988:Proteasome Endopeptidase Complex; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology; D014452:Ubiquitins / Q000235:genetics*
chemical_list: D000906:Antibodies; D009097:Multienzyme Complexes; D014409:Tumor Necrosis Factor-alpha; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex