Hemolytic anemias in pregnancy.
Polymorphism exists and complicates the diagnosis of inherited hemolytic anemias. However, with linkage DNA analysis and, on occasion, with characterization of the mutant gene, it is possible to make a diagnosis on the DNA level. This technique increases our understanding of the enzymatic defect and the relationship with clinical findings. In acquired hemolytic anemias, pregnancy is one of the most commonly associated conditions. The physiology is not yet entirely understood and, therefore, does not allow specific treatment. Supportive therapy is usually the rule in these cases.
Leduc
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University of Montreal, Sainte-Justine Hospital, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada.
D000743:Anemia, Hemolytic / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000628:therapy