title: Secondary amyloidosis in patients with rheumatoid arthritis: diagnostic and prognostic value of gastroduodenal biopsy.
abstract: Upper gastrointestinal endoscopy was performed in patients with rheumatoid arthritis (RA) during the period 1989-1991, and biopsy specimens were obtained from the stomach and from the duodenum for examining amyloid deposits. Among 407 patients, gastrointestinal amyloidosis was confirmed in 54 (13.3%). Twenty-two patients were regarded as having slight amyloid deposits, while 32 patients were categorized as having marked amyloid deposits. The incidence of clinical manifestations suggestive of systemic amyloidosis was more frequent in the marked deposits group than in the slight deposits group (47% vs 14%, P<0.05). Among the patients who died of manifestations associated with amyloidosis, the survival period following endoscopy was shorter in the marked deposits group than in the slight deposits group. These findings suggest that gastroduodenal biopsies may be useful for diagnosing secondary amyloidosis and that the degree of amyloid deposits seems to be correlated with the clinical manifestations of RA.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Tada
authors.forename: T
authors.initials: T
authors.lastname: Fuchigami
authors.forename: Y
authors.initials: Y
authors.lastname: Okuda
authors.forename: K
authors.initials: K
authors.lastname: Takasugi
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Iida
authors.forename: K
authors.initials: K
authors.lastname: Aoyagi
authors.forename: A
authors.initials: A
authors.lastname: Iwashita
authors.forename: Y
authors.initials: Y
authors.lastname: Daimaru
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D004386:Duodenum / Q000737:chemistry* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D013270:Stomach / Q000737:chemistry* / Q000473:pathology; D015996:Survival Rate; D013997:Time Factors
chemical_list: D000682:Amyloid