title: Growth and physical outcome of children conceived by in vitro fertilization.
abstract: OBJECTIVE
  To determine the growth and physical outcome at 2 years of age for children born after assisted reproductive techniques in the state of Victoria.
  
  
  METHODS
  Using a case-matched control study between January 1991 and July 1993, 314 children (196 singletons, 47 sets of twins, 8 sets of triplets) conceived after in vitro fertilization (IVF) and related techniques at the Monash IVF and Royal Women's Hospital Reproductive Biology Unit and 150 control children (113 singletons, 17 sets of twins, 1 set of triplets) randomly selected from the general population using the Victorian Perinatal Data Collection Unit records were enrolled to be examined for minor dysmorphic and major organ abnormalities. Singleton and twin cases were matched for plurality and gestation and date of birth. Triplets were not matched.
  
  
  RESULTS
  IVF status was not a significant independent factor for physical outcomes, including malformation rates, nor for days of hospitalization postdischarge and operations. There was no significant interaction between IVF status and mean percentiles for weight and head circumference. The IVF group had a greater mean length percentile. Twins in both groups had significantly poorer physical outcomes than singletons on some measures.
  
  
  CONCLUSIONS
  This study did not demonstrate an independent IVF effect on the growth and physical outcome of children at 2 years of age when matched for plurality and gestation. The poor outcomes where noted were related to the effects of multiple births. These findings must be viewed in context of the response rates and therefore representativeness of the data. The need for longitudinal studies is demonstrated.
authors.affiliation: Monash University Department of Psychological Medicine, Monash Medical Centre, Victoria, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Saunders
authors.forename: J
authors.initials: J
authors.lastname: Spensley
authors.forename: J
authors.initials: J
authors.lastname: Munro
authors.forename: G
authors.initials: G
authors.lastname: Halasz
mesh_terms: D000328:Adult; D001724:Birth Weight; D001827:Body Height; D016022:Case-Control Studies; D002508:Cephalometry; D002657:Child Development; D002675:Child, Preschool; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D005307:Fertilization in Vitro; D005865:Gestational Age; D006128:Growth; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D010351:Patient Discharge; D013514:Surgical Procedures, Operative; D014310:Triplets; D014427:Twins; D014739:Victoria / Q000453:epidemiology