title: Use of larger sized aortic homograft conduits in right ventricular outflow tract reconstruction.
abstract: Between 1973 and 1993 sixty aortic homograft valved conduits in fifty-six patients were used to establish continuity between the right ventricle and the pulmonary artery in congenital heart disease. Age range was one day to 23.5 years (median 3.6 years) which included twenty-six patients less than one-year-old. Conduit size ranged from 11 to 23 mm (median 17.6 mm). there were nine hospital deaths and eight late deaths. The 45 survivors have been followed for a median of 8.6 years (range 6 months to 20 years). All patients have had serial echocardiographic assessments and 35 have had post repair cardiac catheterization. Almost all patients had mild-to-moderate degrees of homograft regurgitation. There were eleven with severe homograft regurgitation and two are being considered for reoperation. The follow up homograft gradient ranged from 0 to 64 mmHg (mean 24 mmHg). Freedom from reoperation for conduit obstruction was 98.2% at five years falling to 91% (C.L. 82%-100%) at 10 years. Of the 23 homografts inserted more than 10 years ago, only one (4.3%) has been replaced because it was causing important obstruction. None have been replaced for regurgitation. Our results indicate that larger sized aortic homografts used in reconstruction of the right ventricular outflow tract give satisfactory results and there is a low incidence of reoperation for replacement at medium term follow up.
authors.affiliation: Wessex Cardiothoracic Centre, University Hospital, Southhampton, England.
authors.forename: R K
authors.initials: RK
authors.lastname: Tam
authors.forename: M J
authors.initials: MJ
authors.lastname: Tolan
authors.forename: V Y
authors.initials: VY
authors.lastname: Zamvar
authors.forename: Z
authors.initials: Z
authors.lastname: Slavik
authors.forename: R
authors.initials: R
authors.lastname: Pickering
authors.forename: B R
authors.initials: BR
authors.lastname: Keeton
authors.forename: A P
authors.initials: AP
authors.lastname: Salmon
authors.forename: S A
authors.initials: SA
authors.lastname: Webber
authors.forename: V
authors.initials: V
authors.lastname: Tsang
authors.forename: R K
authors.initials: RK
authors.lastname: Lamb
mesh_terms: D001021:Aortic Valve / Q000637:transplantation*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D012189:Retrospective Studies; D015996:Survival Rate; D014184:Transplantation, Homologous