[The metabolic aspects of the sequelae of the accident at the Chernobyl Atomic Electric Power Station in the course of kidney diseases].
As many as 159 patients with chronic pyelonephritis and 100 those with glomerulonephritis residing in ecologically favourable, and on contaminated territories for 6-8 years after Chernobyl accident, were examined for indices of lipid peroxidation, antioxidant system and energy exchange. The above renal disease were found to be accompanied by a rise in the activity of lipid peroxidation and accumulation of excess of their products in cellular membranes and urine. In the antioxidant system, the activity of NAD-H2-dependent factors and an inhibitor of free radical oxidation of superoxiddismutase tends to decrease. There occur changes in isoenzyme spectrum of lactate and malatedehydrogenases. The above shifts appear to be manifest in those persons having been exposed to low radiation doses. Antioxidants and stabilizers of the biological membranes were shown to be useful in correcting the above metabolic processes.
Vozianov
O F
OF
Pyrih
L A
LA
Nikulina
H H
HH
Pasiechnikov
S P
SP
Dudar
I O
IO
D000398:Air Pollution, Radioactive / Q000009:adverse effects*; D000975:Antioxidants / Q000528:radiation effects; D002908:Chronic Disease; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects*; D005921:Glomerulonephritis / Q000201:enzymology*; D006801:Humans; D015227:Lipid Peroxidation / Q000528:radiation effects; D011210:Power Plants; D011704:Pyelonephritis / Q000201:enzymology*; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine
D000975:Antioxidants