Taurine accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats.
The effects of taurine on the regression of pre-established hypercholesterolemia were examined in stroke-prone spontaneously hypertensive rats (SHRSP). Hypercholesterolemia was induced by feeding a hypercholesterolemic diet to SHRSP for 30 days. Then, the diet was switched to normal chow with or without 3% taurine, and the effects were followed up for another 30 days. During regression serum cholesterol level was rapidly decreased, and was accelerated by taurine. A similar accelerated decrease in cholesterol content by taurine was seen also in tissues including the liver, intestine, and aorta. In the liver, acyl-CoA:cholesterol acyltransferase (ACAT) activity was significantly low in the taurine-supplemented group, parallel with the hepatic cholesteryl ester content. On the other hand, hepatic cholesterol 7 alpha-hydoxylase activity maintained a higher level in the taurine-supplemented group. These results showed that taurine accelerates the regression of hypercholesterolemia, and suggested that this effect is related to the increase in cholesterol catabolism to bile acid through the enhancement of 7 alpha-hydoxylase activity.
Murakami
S
S
Medicinal Research Laboratory, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
Nara
Y
Y
Yamori
Y
Y
D000818:Animals; D002561:Cerebrovascular Disorders; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004198:Disease Susceptibility; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D013654:Taurine / Q000627:therapeutic use*
D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D013654:Taurine; D002790:Cholesterol 7-alpha-Hydroxylase; D002785:Sterol O-Acyltransferase