A tau promoter region without neuronal specificity.
The microtubule-associated protein tau is produced from a 6-kb mRNA expressed primarily in neurons. A 2-kb tau mRNA has also been characterized, which produces a tau isoform that localizes to the nucleus, and an 8-kb mRNA is expressed in the PNS. Mapping and sequencing of the human tau gene start showed that it has an unusually GC-rich 5'-untranslated region coded by a single untranslated exon (designated -1). Primer extensions and expression assays indicated that upstream of exon -1 is a promoter that is not neuron specific. This region contains consensus binding sites for transcription factors AP2, Sp1, and GCF.
Andreadis
A
A
Department of Neurology (Neuroscience), Harvard Medical School, Boston, Massachusetts, USA.
Wagner
B K
BK
Broderick
J A
JA
Kosik
K S
KS
D001483:Base Sequence; D003596:Cytosine / Q000502:physiology; D005091:Exons / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics*; D017930:Genes, Reporter / Q000235:genetics; D006147:Guanine / Q000502:physiology; D006367:HeLa Cells / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012680:Sensitivity and Specificity; D014158:Transcription, Genetic / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins; D006147:Guanine; D003596:Cytosine