title: Development of endothelial nitric oxide synthase in endothelial cells in the human cerebrum.
abstract: We demonstrate the distribution and development of endothelial nitric oxide synthase (eNOS) immunoreactivity in vessels of the human brain. eNOS-positive endothelial cells were recognized in small vessels in the parenchyma of the cerebrum, as well as in the large arteries and veins in the leptomeninges. By 10-13 weeks of gestation, eNOS-positive endothelial cells had already appeared in the vessels of the leptomeninges and deep white matter. Immunoreactivity for eNOS was noted in most vessels at 14-17 weeks in the intermediate white matter, at 18-21 weeks in the cortex, and at 23-26 weeks in the subcortical white matter. Such differences in regional development may be responsible in part for the topographical predilection for hemorrhagic or hypoxic-ischemic lesions in the developing brain.
authors.affiliation: Department of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyawaki
authors.forename: O
authors.initials: O
authors.lastname: Sohma
authors.forename: M
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: S
authors.initials: S
authors.lastname: Takashima
mesh_terms: D001921:Brain / Q000098:blood supply / Q000196:embryology* / Q000201:enzymology; D005314:Embryonic and Fetal Development / Q000502:physiology; D004730:Endothelium, Vascular / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D019001:Nitric Oxide Synthase / Q000032:analysis*
chemical_list: D019001:Nitric Oxide Synthase