Serum levels of endometrial proteins during transcervical resection of the endometrium.
OBJECTIVE
To study the potential for dissemination of endometrial tissue substances during transcervical resection of the endometrium (TCRE).


METHODS
Prospective study.


METHODS
One university and two county hospitals.


METHODS
Forty-eight women with dysfunctional bleeding.


METHODS
The serum levels of two endometrial proteins, insulin-like growth factor binding protein-1 (IGFBP-1) and placental protein 14 (PP14), were measured before and every 10 min during the operations. Blood loss was also measured by a photometer together with absorption of the irrigating fluid containing glycine 1.5% and ethanol 1% by expired-breath tests, and serum sodium and volumetric fluid balances.


METHODS
Linear correlations between changes in IGFBP-1 and PP14 during TCRE and operating parameters such as operating time, blood loss and fluid absorption.


RESULTS
The baseline levels of IGFBP-1 were normal but PP14 could only be detected in one third of the patients, which was due, in part, to pre-operative treatment with danazol. The highest levels of IGFBP-1 and PP14 during surgery correlated positively with the baseline concentrations. Fluid absorption (median 405 ml, range 0-2177) was the only surgical factor associated with increasing serum levels of endometrial proteins.


CONCLUSIONS
Absorption of the solution used to irrigate the uterus is associated with dissemination of endometrial products in the bloodstream during TCRE.
Hahn
R G
RG
Department of Anaesthesia, Stockholm South Hospital, Sweden.
Olsson
J
J
Englund
K
K
Seppälä
M
M
D000328:Adult; D004717:Endometrium / Q000601:surgery*; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D007430:Intraoperative Care; D008875:Middle Aged; D011257:Pregnancy Proteins / Q000097:blood*; D011300:Preoperative Care; D011446:Prospective Studies; D012044:Regression Analysis; D014592:Uterine Hemorrhage / Q000097:blood* / Q000601:surgery
D000071816:Glycodelin; D006023:Glycoproteins; D018970:Insulin-Like Growth Factor Binding Protein 1; C045246:PAEP protein, human; D011257:Pregnancy Proteins