Treatment of vaginitis.
OBJECTIVE
The purpose of this study was to evaluate the efficacy of metronidazole 500 mg and miconazole nitrate 100 mg (Neo-Penotran, Embil Pharmacy Company, Istanbul, Turkey) in the treatment of vaginitis.


METHODS
One hundred patients (mean age 26.5 years, range 18-50) with a clinical diagnosis of vaginitis entered this open, noncomparative study. Each patient inserted a Neo-Penotran pessary twice daily for 14 days. Assessments were carried out at the beginning of the study and 15 and 22 days after the start of therapy. Student's t-test was used for the statistical analysis.


RESULTS
Out of 100 patients who were initially recruited to the study, 20 were subsequently excluded, leaving a total of 80 patients (80%) who completed the full course of treatment. Vaginitis was resolved in 75% of cases, it improved in 18% and was unchanged in 7%. The success rate for the treatment of trichomoniasis was 80%, 93.4% for bacterial vaginosis and 84.4% for candidal vaginitis.


CONCLUSIONS
Neo-Penotran pessaries represent a novel and effective formulation for the treatment of common types of vaginitis and this pessary may also be of particular value in the treatment of resistant or recurrent vaginitis.
Kükner
S
S
Dr Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
Ergin
T
T
Ciçek
N
N
Uğur
M
M
Yeşilyurt
H
H
Gökmen
O
O
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D000994:Antitrichomonal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D008825:Miconazole / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000188:drug therapy*; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
D000935:Antifungal Agents; D000994:Antitrichomonal Agents; D008795:Metronidazole; D008825:Miconazole