Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle.
Effects of a set of alpha-ketoglutarate phosphoanalogues on the activity of alpha-ketoglutarate dehydrogenase (EC 1.2.4.2) complexes from E. coli and pigeon breast muscle, as well as on alpha-ketoglutarate dehydrogenase isolated from the pigeon breast muscle, have been studied. alpha-Ketoglutarate phosphoanalogues (succinyl phosphonate and its monomethyl ester) were found to be effective inhibitors of alpha-ketoglutarate oxidative decarboxylation, catalyzed by both muscle and bacterial alpha-ketoglutarate dehydrogenase complexes, as well as muscle alpha-ketoglutarate dehydrogenase. The ability of glutamate phosphoanalogues to inhibit alpha-ketoglutarate oxidative decarboxylation has been shown in E. coli extract and a model system.
Biryukov
A I
AI
V.A. Engelhardt Institute of Molecular Biology, Moscow, Russia.
Bunik
V I
VI
Zhukov
Y N
YN
Khurs
E N
EN
Khomutov
R M
RM
D000818:Animals; D010856:Columbidae; D003653:Decarboxylation; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology*; D007655:Ketoglutarate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D007656:Ketoglutaric Acids / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000201:enzymology*; D063065:Organophosphonates / Q000494:pharmacology*; D010084:Oxidation-Reduction; D013386:Succinates / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D007656:Ketoglutaric Acids; D063065:Organophosphonates; D013386:Succinates; C099145:succinyl phosphonate; D007655:Ketoglutarate Dehydrogenase Complex