Sequential treatment of recurrent mesenteric desmoid tumor.
BACKGROUND
The optimal management of inoperable desmoid tumors is still unclear. We report a 26 year-old female patient with familial adenomatous polyposis suffering from a recurrent inoperable intraabdominal desmoid tumor and its sequential treatment.


METHODS
Treatment strategies included low-dose tamoxifen (30 mg orally per day), high-dose tamoxifen (90 mg orally per day), and a subsequent combination of goserelin acetate (3.6 mg subcutaneously once every four weeks) plus low-dose tamoxifen, medroxyprogesterone acetate (1000 mg orally per day) and interferon gamma (3 Mio IU subcutaneously 3 times a week).


RESULTS
The combination of goserelin acetate and low-dose tamoxifen resulted in a decrease in tumour size and a complete relief of symptoms for 17 months. Thereafter the tumor progressed and again growth was stopped with interferon gamma therapy for another 6 months. All other treatment modalities had no effect.


CONCLUSIONS
This study demonstrates long-term regression of a desmoid tumor with combined endocrine therapy using goserelin acetate plus tamoxifen. Tumor progression after 17 months was again stopped by a combination of interferon-gamma and goserelin acetate.
Bauernhofer
T
T
Department of Internal Medicine, Division of Oncology, Karl Franzens University, Graz, Austria.
Stöger
H
H
Schmid
M
M
Smola
M
M
Gürtl-Lackner
B
B
Höfler
G
G
Ranner
G
G
Reisinger
E
E
Samonigg
H
H
D011125:Adenomatous Polyposis Coli / Q000473:pathology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D018222:Desmoid Tumors / Q000000981:diagnostic imaging / Q000628:therapy*; D017273:Goserelin / Q000008:administration & dosage; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage; D008525:Medroxyprogesterone / Q000008:administration & dosage; D008643:Mesentery; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D013629:Tamoxifen / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
D013629:Tamoxifen; D017273:Goserelin; D007371:Interferon-gamma; D008525:Medroxyprogesterone