title: Radiation-associated gliosarcoma.
abstract: The authors report a case of radiation-associated intracerebral gliosarcoma with fibrosarcomatous predominance, arising at the site of a low-grade glioma treated 10 years previously. The features of this case conform to the accepted criteria for radiation-induced tumour, in that the tumour developed within the radiation field, differed dramatically in histologic features from the original tumour and did not develop until 10 years after treatment. Although such tumours are most uncommon, this case suggests that radiation-induced gliosarcoma should be considered in the differential diagnosis of recurrent mass at the site of a treated intracranial neoplasm.
authors.affiliation: Department of Diagnostic Imaging, Foothills Hospital, Calgary, Alta.
authors.forename: M
authors.initials: M
authors.lastname: Lach
authors.forename: C J
authors.initials: CJ
authors.lastname: Wallace
authors.forename: J
authors.initials: J
authors.lastname: Krcek
authors.forename: B
authors.initials: B
authors.lastname: Curry
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology* / Q000532:radiotherapy; D002648:Child; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D005910:Glioma / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed