Fast axonal transport rates are unchanged in 6- and 24-month F344 rats.
The maximum rate of fast axonal transport in motor axons at 6 and 24 months was measured in F344 rats. Tritiated proline was injected near sciatic motoneurons and rats were killed after 2-5 h. Nerves were processed for liquid scintillation spectroscopy and fast transport rates calculated. The rates, in 6- and 24-month rats, were 373 +/- 12 mm/day and 368 +/- 10 mm/day, respectively. Thus, the maximum fast transport rate is unchanged with age in F344 rats.
Jacob
J M
JM
Department of Anatomical Sciences, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City 73104, USA.
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000502:physiology*; D008297:Male; D011392:Proline / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D012584:Sciatic Nerve / Q000502:physiology*; D013997:Time Factors
D011392:Proline