Comparative attributes for the description of the relative efficacy of therapeutic agents: general concepts and definitions, and application to the American Dental Association guidelines for the comparison of the clinical anticaries efficacy of fluoride dentifrices.
Comparative attributes are terms or phrases commonly employed in the vernacular of the biomedical literature to convey the results of comparative studies. Examples are such terms as "equivalent" or "superior." Recently, there has developed an increasing tendency in certain areas of application toward the institution of guidelines which provide both a uniform set of criteria for defining such attributes and a set of requirements which must be satisfied in order to demonstrate that such attributes may hold in a particular situation. The present paper provides a general discussion of comparative attributes, from which the application of the underlying concepts to any particular context might better be understood. Second, it provides an explicit and comprehensive discussion regarding the American Dental Associations's guidelines concerning the attributions of "superiority," "equivalence," and "at least as good as," as they are applied to the comparison of the clinical anticaries efficacy of fluoride dentifrices.
Proskin
H M
HM
Department of Community Dentistry, Eastman Dental Center, Rochester, NY, USA.
Kingman
A
A
Naleway
C
C
Woznaik
W T
WT
D000571:American Dental Association; D002327:Cariostatic Agents / Q000592:standards*; D003764:Dental Materials / Q000592:standards*; D018865:Dental Research / Q000592:standards; D003802:Dentifrices / Q000592:standards; D005459:Fluorides / Q000592:standards; D017408:Guidelines as Topic; D006801:Humans; D011785:Quality Assurance, Health Care / Q000458:organization & administration*; D014481:United States
D002327:Cariostatic Agents; D003764:Dental Materials; D003802:Dentifrices; D005459:Fluorides