title: Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate.
abstract: Subcutaneous protein C concentrate (Immuno, Vienna) was used to treat a child with homozygous protein C deficiency who was formerly treated with intravenous protein C concentrate. After 3000 units subcutaneous protein C concentrate (250 iu/kg), protective protein C levels were maintained for 48 h after infusion, with peak levels at 12 h. Subcutaneous protein C concentrate is given every third day and is well tolerated by the patient. No thrombotic events have occurred. We conclude that subcutaneous administration of protein C concentrate is a valuable therapeutic option in the long-term management of homozygous protein C deficiency and avoids the potential hazards of long-term central venous lines.
authors.affiliation: St Luke's Hospital, Bradford.
authors.forename: A M
authors.initials: AM
authors.lastname: Minford
authors.forename: L A
authors.initials: LA
authors.lastname: Parapia
authors.forename: C
authors.initials: C
authors.lastname: Stainforth
authors.forename: D
authors.initials: D
authors.lastname: Lee
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007279:Injections, Subcutaneous; D011486:Protein C / Q000008:administration & dosage / Q000032:analysis; D020151:Protein C Deficiency; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*
chemical_list: D011486:Protein C