title: Intra-oral comparison and evaluation of the ability of fluoride dentifrices to promote the remineralization of caries-like lesions in dentin and enamel.
abstract: The effect of three types of fluoride dentifrices and one non-fluoride dentifrice were evaluated and compared intra-orally for their ability to promote the remineralization of caries-like lesions in thin sections of human dentin and enamel. The three fluoride dentifrices were silica based. One dentifrice contained 0.76% sodium monofluorophosphate (MFP), another contained 0.247% sodium fluoride (NaF), and the third contained 0.247% NaF plus 1.3% pyrophosphate and 1.5% polyvinylmethyl ether/maleic acid (PVM/MA) copolymer (denoted NaF/PPi). The fourth dentifrice (placebo) was also silica based, but contained no fluoride, and served as a negative control. Two week treatment resulted in the following percent mineral changes for the enamel specimens: +21 +/- 16 for MFP, +10 +/- 30 for NaF, +16 +/- 15 for NaF/PPi, and -30 +/- 30 for the placebo. The respective percent mineral change values for the dentin specimens were +28 +/- 20 for MFP, +22 +/- 19 for NaF, +28 +/- 18 for NaF/PPi, and -34 +O/- 61 for the placebo. A statistical analysis revealed that the three fluoride dentifrices were significantly better (p<0.05) than the placebo at promoting remineralization for both types of specimens. No significant differences were found among the three fluoride dentifrices. The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF.
authors.affiliation: Colgate-Palmolive Company, Piscataway, NJ, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Sullivan
authors.forename: R
authors.initials: R
authors.lastname: Fletcher
authors.forename: R
authors.initials: R
authors.lastname: Bachiman
authors.forename: B
authors.initials: B
authors.lastname: Penugonda
authors.forename: R Z
authors.initials: RZ
authors.lastname: LeGeros
mesh_terms: D000704:Analysis of Variance; D003731:Dental Caries / Q000188:drug therapy* / Q000378:metabolism; D003743:Dental Enamel / Q000378:metabolism; D003802:Dentifrices / Q000627:therapeutic use*; D003804:Dentin / Q000378:metabolism; D011756:Diphosphates / Q000627:therapeutic use; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use; D011095:Polyethylenes / Q000627:therapeutic use; D011145:Polyvinyls / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D003802:Dentifrices; D011756:Diphosphates; D008298:Maleates; D010710:Phosphates; D011095:Polyethylenes; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; C012980:fluorophosphate; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D005459:Fluorides