The Nigerian I/CDC strain of Plasmodium ovale in chimpanzees.
The chimpanzee is the only animal host currently available that can support the development of the human malaria parasite Plasmodium ovale. Thirty-one infections with the Nigerian I/CDC strain were induced in splenectomized chimpanzees. Maximum parasite counts ranged from 1,240 to 127,224/microliters. Infections were transient and unpredictable. Anopheles stephensi, Anopheles gambiae, Anopheles freeborni, and Anopheles dirus mosquitoes were infected by feeding through parafilm membranes on heparinized blood containing gametocytes; each species supported development to sporozoites in the salivary glands. Mean oocyst counts per infected mosquito ranged from 1 to 85.1; 21.7% of infected lots of mosquitoes averaged > 20 oocysts per positive mosquito gut. One infection was induced via the bites of infected An. gambiae. The prepatent period was 16 days.
Morris
C L
CL
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
Sullivan
J S
JS
McClure
H M
HM
Strobert
E
E
Richardson
B B
BB
Galland
G G
GG
Goldman
I F
IF
Collins
W E
WE
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D018420:Ape Diseases / Q000276:immunology / Q000469:parasitology*; D007303:Insect Vectors / Q000469:parasitology; D008288:Malaria / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D009549:Nigeria; D002679:Pan troglodytes / Q000469:parasitology*; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology / Q000662:veterinary; D010961:Plasmodium / Q000276:immunology / Q000502:physiology*; D013156:Splenectomy / Q000662:veterinary