[A comparative study of hepatic cholestasis after infusion of long chain triglycerides and a mixture of medium and long chain triglycerides].
A randomized, double blind prospective study made on surgical patients who required parenteral nutrition during a 10-day period, with complete fasting. The patients were required to show a normal hepatic function measured by gamma-GT, alkaline phosphatase (FA), normal bilirubin and ALT. The evolution of the cholestasis parameters was observed on days 0, 1, 3, 8 and 10. An increase in gamma-GT was observed in the groups. This was much greater in the group with LCT (p<0.005) on the tenth day than in the MCT/LCT group. FA increased only in the LCT group, and was statistically significant (p<0.001) on the tenth day compared with the MCT/LCT group.
Jaurrieta
E
E
Servicio de Cirugía, Universidad de Barcelona (España).
Biondo
S
S
Rafecas
A
A
Moreno-Llorente
P
P
Murgoitio
J
J
Llop
J
J
Fabregat
J
J
Figueras
J
J
D000328:Adult; D000368:Aged; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011446:Prospective Studies; D013997:Time Factors; D014280:Triglycerides / Q000008:administration & dosage*
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides