title: Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
abstract: It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.
authors.affiliation: Cancer Genetics Laboratory, Imperial Cancer Research Fund (ICRF) Laboratories, London, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Novelli
authors.forename: J A
authors.initials: JA
authors.lastname: Williamson
authors.forename: I P
authors.initials: IP
authors.lastname: Tomlinson
authors.forename: G
authors.initials: G
authors.lastname: Elia
authors.forename: S V
authors.initials: SV
authors.lastname: Hodgson
authors.forename: I C
authors.initials: IC
authors.lastname: Talbot
authors.forename: W F
authors.initials: WF
authors.lastname: Bodmer
authors.forename: N A
authors.initials: NA
authors.lastname: Wright
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002999:Clone Cells; D003106:Colon / Q000473:pathology*; D015342:DNA Probes; D005838:Genotype; D006801:Humans; D007082:Ileum / Q000473:pathology; D017403:In Situ Hybridization; D017404:In Situ Hybridization, Fluorescence; D007413:Intestinal Mucosa / Q000473:pathology*; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D010641:Phenotype; D014998:Y Chromosome
chemical_list: D015342:DNA Probes