title: A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation.
abstract: A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A, -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.
authors.affiliation: Nuffield Department of Surgery, Oxford Transplant Centre, Churchill Hospital, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Barnardo
authors.forename: N J
authors.initials: NJ
authors.lastname: Davey
authors.forename: M
authors.initials: M
authors.lastname: Bunce
authors.forename: P A
authors.initials: PA
authors.lastname: Brookes
authors.forename: R I
authors.initials: RI
authors.lastname: Lechler
authors.forename: K I
authors.initials: KI
authors.lastname: Welsh
authors.forename: J R
authors.initials: JR
authors.lastname: Batchelor
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005805:Genes, MHC Class I; D015236:HLA-C Antigens / Q000032:analysis* / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007526:Isoelectric Point; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015236:HLA-C Antigens