Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA).
A new type of tandem base lesion has been observed in d(CpGpTpA) X-irradiated in aqueous solution. The lesion is attributed to the formation of a covalent bond between the C8 carbon atom of guanine and the methyl carbon atom of thymine. This tandem base lesion is formed in the absence of oxygen. It is the main product produced by ionizing radiation under these conditions.
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Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA.
Budzinski
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Dawidzik
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Wallace
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JC
Evans
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MS
Gobey
J S
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D000135:Acid Phosphatase; D000818:Animals; D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D003849:Deoxyguanosine; D008297:Male; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000528:radiation effects*; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011467:Prostate / Q000201:enzymology; D013936:Thymidine; D014965:X-Rays
D009838:Oligodeoxyribonucleotides; D000135:Acid Phosphatase; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I; D003849:Deoxyguanosine; D013936:Thymidine