title: Evaluation of inductively heated ferromagnetic alloy implants for therapeutic interstitial hyperthermia.
abstract: Ferromagnetic alloys heated by magnetic induction have been investigated as interstitial hyperthermia delivery implants for over a decade, utilizing low Curie temperatures to provide thermal self-regulation. The minimally invasive method is attractive for fractionated thermal treatment of tumors which are not easily heated by focused microwave or ultrasound techniques. Past analyses of ferromagnetic seeds by other authors depict poor experimental correlation with theoretical heating predictions. Improvements in computer hardware and commercially available finite element analysis software have simplified the analysis of inductively heated thermal seeds considerably. This manuscript examines end effects of finite length implants and nonlinear magnetic material properties to account for previous inconsistencies. Two alloys, Ni-28 wt% Cu (NiCu) and Pd-6.15 wt% Co (PdCo), were used for comparison of theoretical and experimental calorimetric results. Length to diameter (L/d) ratios of over 20 for cylindrical seeds are necessary for minimization of end effects. Magnetic properties tested for alloys of NiCu and PdCo illustrate considerable nonlinearity of these materials in field strength ranges used for induction heating. Field strength dependent magnetic permeabilities and calorimetric data illustrate that more detailed material information must be included to accurately estimate induction power loss for these implants.
authors.affiliation: Department of Pathology, University of Iowa, Iowa City 52242, USA. japaulus@icaen.uiowa.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Paulus
authors.forename: J S
authors.initials: JS
authors.lastname: Richardson
authors.forename: R D
authors.initials: RD
authors.lastname: Tucker
authors.forename: J B
authors.initials: JB
authors.lastname: Park
mesh_terms: D000497:Alloys / Q000737:chemistry; D002151:Calorimetry / Q000295:instrumentation / Q000706:statistics & numerical data; D003035:Cobalt / Q000737:chemistry; D003198:Computer Simulation; D003300:Copper / Q000737:chemistry; D004867:Equipment Design / Q000706:statistics & numerical data; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000706:statistics & numerical data; D008962:Models, Theoretical; D009532:Nickel / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D019736:Prostheses and Implants / Q000706:statistics & numerical data; D013696:Temperature
chemical_list: D000497:Alloys; D005290:Ferric Compounds; C062136:nickel copper alloy; C099370:palladium-cobalt alloy; C001215:ferrite; D003035:Cobalt; D010165:Palladium; D003300:Copper; D009532:Nickel