Different action of xenoreactive natural and immune antibodies on functioning cardiomyocytes.
PNAB and IAB have totally different action on BCM. PNAB inhibit the contractile function of BCM by producing a reversible standstill and by disturbing the synchronization of the BCM-monolayer. IAB are cytotoxic and depend on the presence of complement.
Autenrieth
A
A
Institute for Surgical Research, Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
Müller-Werdan
U
U
Koidl
B
B
Werdan
K
K
Hammer
C
C
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000276:immunology*; D000910:Antibodies, Heterophile / Q000276:immunology*; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006321:Heart / Q000502:physiology; D006801:Humans; D007700:Kinetics; D009200:Myocardial Contraction; D009206:Myocardium / Q000276:immunology*; D051381:Rats; D013997:Time Factors
D000906:Antibodies; D000910:Antibodies, Heterophile; D003165:Complement System Proteins