Synthesis and anticonvulsant activity of new acylthiosemicarbazides and thiazolidones.
A number of 1-(3-phenyl-4(3H)-quinazolinone-2-ylmercaptoacetyl)-4-substituted thiosemicarbazide and 2-(3-phenyl-4(3H)-quinazolinone-2-ylmercaptoacetylhydrazono)-3-sub stituted 4-thiazolidone derivatives were synthesized and evaluated for anticonvulsant activity. Some of the tested compounds showed significant activity against MES and ScMet induced seizures.
Gürsoy
A
A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Karali
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N
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D012663:Semicarbazides; C005151:thiosemicarbazide