title: Chlorinated hydrocarbons in human bone marrow of healthy individuals and leukemia patients.
abstract: In this pilot study, concentrations of chlorinated hydrocarbons in bone marrow were determined by capillary-column gas chromatography. Bone marrow was obtained from a total of 29 healthy adults and from patients with leukemia or lymphoma. The chlorinated hydrocarbons in adults that occurred in the highest concentrations were dichlorodiphenyltrichloroethane and its derivatives (mean = 129 mg/g DNA). Hexachlorobenzene, the hexachlorohexane isomers, and dieldrin were also found, but in reduced concentrations (i.e., mean concentrations: 49.5 mg/g DNA, 14.9 mg/g DNA, and 5.9 mg/g DNA, respectively). Patients who had leukemia and lymphoma did not have significantly increased concentrations of chlorinated hydrocarbons.
authors.affiliation: UCSD Medical School, Department of Medicine, La Jolla, California, USA.
authors.forename: J
authors.initials: J
authors.lastname: Scheele
authors.forename: M
authors.initials: M
authors.lastname: Teufel
authors.forename: K H
authors.initials: KH
authors.lastname: Niessen
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000737:chemistry*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D007938:Leukemia / Q000378:metabolism*; D008223:Lymphoma / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013921:Thrombocytopenia / Q000378:metabolism; D014019:Tissue Donors
chemical_list: D006843:Hydrocarbons, Chlorinated