title: Studies on dressings for mucosa of the oral cavity. Part 3: Effect of preparation technology on the physical and chemical properties of stomatological xerogel dressings.
abstract: Adhesion of xerogel dressings prepared on Eudragit (E), methylcellulose (MC) and glycerol compositions, remaining within the range of 625-650 g, after addition polyvinylpyrolidone (PVP) amounts to 450-1250 g. Dissolution time from xerogel dressings without PVP additive both in water and in an artificial gastric juice amounts to 3 h. Addition of PVP results in reduction of the elution rate. In dependence upon the PVP/E/MC ratio elution time amounts to 3-3.5 h. Pharmaceutical availability of the Kunitz protease inhibitor in particular groups of then dressings depends upon concentration of hydrophilizing agent. The semi-liberation times amounts to 3.65-17.50 h.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silesian Piasts Memorial Medical Academy, Wrocław, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Małecka
authors.forename: A
authors.initials: A
authors.lastname: Kubis
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000378:metabolism; D000268:Adhesiveness; D000596:Amino Acids / Q000378:metabolism; D007611:Aprotinin / Q000494:pharmacology; D001458:Bandages; D005750:Gastric Juice; D005782:Gels; D006490:Hemostatics / Q000494:pharmacology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006868:Hydrolysis; D008747:Methylcellulose / Q000737:chemistry / Q000378:metabolism; D009061:Mouth Mucosa / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D011109:Polymethacrylic Acids; D012995:Solubility
chemical_list: D000180:Acrylic Resins; D000596:Amino Acids; D005782:Gels; D006490:Hemostatics; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D008747:Methylcellulose; D007611:Aprotinin