title: Psychologic and neuropsychologic impact of autologous bone marrow transplantation.
abstract: OBJECTIVE
  The major purpose of the current study was to evaluate the psychologic and neuropsychologic functioning of patients undergoing treatment with autologous bone marrow transplantation (ABMT).
  
  
  METHODS
  Fifty-four patients with hematologic disorders or breast cancer completed a battery of psychologic and neuropsychologic tests before ABMT, at mid-treatment (1 to 3 days following bone marrow reinfusion), and predischarge (within 1 to 2 days before discharge from the hospital).
  
  
  RESULTS
  Analysis of pretransplant data showed significantly higher scores on the State-Trait Anxiety Inventory (STAI) and Profile of Mood States (POMS) for patients with hematologic disorders as compared with patients with breast cancer. However, no baseline differences on neuropsychologic measures were found when patients were divided into groups based on prior exposure to cranial radiation and/or intrathecal chemotherapy. Serial evaluations at pretransplant, following return of bone marrow, and at predischarge were available for 34 patients. For the psychologic data, patients with hematologic disorders tended to be more distressed than breast cancer patients at baseline, but became less distressed over time. By contrast, breast cancer patients were relatively less distressed at baseline, demonstrated a significant increase in distress midtreatment, and returned to baseline levels at predischarge assessment. Scores on neuropsychologic measures that assessed higher order cognitive functioning generally worsened over time.
  
  
  CONCLUSIONS
  The results suggest a differential response on psychologic measures when comparing patients with hematologic disorders with those with breast cancer. However, both groups demonstrated a general decline in performance on neuropsychologic measures over the course of treatment.
authors.affiliation: Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Ahles
authors.forename: D M
authors.initials: DM
authors.lastname: Tope
authors.forename: C
authors.initials: C
authors.lastname: Furstenberg
authors.forename: D
authors.initials: D
authors.lastname: Hann
authors.forename: L
authors.initials: L
authors.lastname: Mills
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D000704:Analysis of Variance; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001007:Anxiety; D016026:Bone Marrow Transplantation / Q000523:psychology*; D001943:Breast Neoplasms / Q000523:psychology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000523:psychology* / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000523:psychology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000523:psychology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies