High-dose oral dexamethasone therapy for chronic childhood idiopathic thrombocytopenic purpura.
Because high-dose oral dexamethasone therapy has been reported to be effective for adults with idiopathic thrombocytopenic purpura, we assessed the short-term efficacy and toxicity of dexamethasone in seven children with chronic or refractory idiopathic thrombocytopenic purpura. Dexamethasone therapy was effective and well tolerated; further long-term studies are warranted.
Adams
D M
DM
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Kinney
T R
TR
O'Branski-Rupp
E
E
Ware
R E
RE
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone