title: Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC.
abstract: We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Phildelphia, PA 19111, USA.
authors.forename: N A
authors.initials: NA
authors.lastname: Lissy
authors.forename: A
authors.initials: A
authors.lastname: Bellacosa
authors.forename: G
authors.initials: G
authors.lastname: Sonoda
authors.forename: P D
authors.initials: PD
authors.lastname: Miller
authors.forename: S C
authors.initials: SC
authors.lastname: Jhanwar
authors.forename: J R
authors.initials: JR
authors.lastname: Testa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D017124:Conserved Sequence; D018076:DNA, Complementary; D006602:Hexosyltransferases; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D008565:Membrane Proteins; D006602:Hexosyltransferases; C099573:STT3A protein, human