[The effect of diazepam and flumazenil on pulsatile secretion of prolactin and LH in women].
The authors examined the effect of diazepam and flumazenil on prolactin and LH secretion in women. The experiment lasted 12 hours during which specimens of venous blood were collected for assessment of LH and prolactin after 10-minute intervals. After 5 hours to a group of 8 women (4 in the luteal and 4 in the follicular stage of the cycle) flumazenil was administered--3 x 10 mg i.v. after 30 minute intervals, and to a group of 7 women (3 in the follicular and 4 in the luteal stage of the cycle) diazepam was administered--10 mg i.v. after 30-minute intervals. Flumazenil administration did not affect the LH or prolactin secretion. Diazepam caused in 3 of 4 women in the luteal phase of the cycle a significant rise of the prolactin secretion (p < 0.001), in the remaining women in the luteal phase and 3 women in the follicular stage a rise of prolactin was recorded but it did not reach statistical significance. The LH level was significantly influenced (i.e. decreased) in one of 7 women.
Cepický
P
P
Ustav pro péci o matku a dítĕ, Praha.
Roth
Z
Z
Stroufová
A
A
Sosnová
K
K
Pecená
M
M
D000328:Adult; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005442:Flumazenil / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D008597:Menstrual Cycle; D011388:Prolactin / Q000378:metabolism*
D018757:GABA Modulators; D005442:Flumazenil; D011388:Prolactin; D007986:Luteinizing Hormone; D003975:Diazepam