The biological activity of cyclic bis(bibenzyls): a rational approach.
The biological activities reported for marchantin A (1), a natural cyclic bis(bibenzyl), were studied in comparison with cepharanthine (2), a therapeutically useful bisbenzylisoquinoline alkaloid. Based on the examination of steric, electrostatic, and hydrophobic similarity, as well as on the comparison of biological activities, the similar therapeutic properties of 1 and 2 can be attributed to binding on a common receptor. The wide range of activity of 1 can be interpreted by a mechanism of action based on a calcium binding.
Keseru
G M
GM
Department of Chemical Information Technology, Technical University of Budapest, Hungary.
Nógrádi
M
M
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D044182:Benzylisoquinolines; D001632:Bibenzyls; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology*; D004988:Ethers, Cyclic; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D010647:Phenyl Ethers / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D013329:Structure-Activity Relationship; D052117:Benzodioxoles
D000470:Alkaloids; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; D001632:Bibenzyls; D002396:Catechols; D004988:Ethers, Cyclic; D010647:Phenyl Ethers; C006947:cepharanthine; D052117:Benzodioxoles; C096123:marchantin A