title: Therapy for lung failure using nitric oxide inhalation and surfactant replacement.
abstract: Nitric oxide inhalation and surfactant replacement therapy are relatively new concepts in the treatment of respiratory failure due to hypoxia and reperfusion injury after lung transplantation. We report on a patient in whom reperfusion injury of the lung developed after resuscitation and implantation of a biventricular assist device for sudden cardiac arrest. Lung failure developed within 12 hours after implantation of the biventricular assist device. Lung function was reestablished using combined therapy of nitric oxide and surfactant. Heart transplantation was performed successfully thereafter. This case indicates the potential role of a combined therapy of nitric oxide and surfactant in acute hypoxic lung failure.
authors.affiliation: Department of Cardiovascular Surgery, Christian Albrechts University, Kiel, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Strüber
authors.forename: M
authors.initials: M
authors.lastname: Brandt
authors.forename: J
authors.initials: J
authors.lastname: Cremer
authors.forename: W
authors.initials: W
authors.lastname: Harringer
authors.forename: S W
authors.initials: SW
authors.lastname: Hirt
authors.forename: A
authors.initials: A
authors.lastname: Haverich
mesh_terms: D000328:Adult; D004338:Drug Combinations; D005233:Fatty Alcohols / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy; D016040:Lung Transplantation; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use*; D010767:Phosphorylcholine; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011183:Postoperative Complications; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology; D012131:Respiratory Insufficiency / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D005233:Fatty Alcohols; D011663:Pulmonary Surfactants; D010767:Phosphorylcholine; D009569:Nitric Oxide; D011092:Polyethylene Glycols; C047049:dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination