title: Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.
authors.affiliation: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, USA.
authors.forename: T S
authors.initials: TS
authors.lastname: Lin
authors.forename: M Z
authors.initials: MZ
authors.lastname: Luo
authors.forename: M C
authors.initials: MC
authors.lastname: Liu
authors.forename: Y L
authors.initials: YL
authors.lastname: Zhu
authors.forename: E
authors.initials: E
authors.lastname: Gullen
authors.forename: G E
authors.initials: GE
authors.lastname: Dutschman
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D006678:HIV / Q000187:drug effects*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D016047:Zalcitabine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D016047:Zalcitabine; C050624:2',3'-dideoxycytidinene; C099405:dexelvucitabine