Progress on vaccination against Haemonchus contortus.
Control of Haemonchus contortus at present is largely by the use of anthelmintics, assisted in some regions by management programs. Widespread development of resistance, particularly in South Africa and Australia, and concerns associated with the manufacture and use of chemicals have led to increasing interest in vaccination as an alternative means of control. Vaccination strategies basically fall into 2 categories, 'hidden' antigens (usually derived from the gastrointestinal tract of the adult parasite), or 'natural' antigens (those exposed to the immune system of the host during the course of infection, usually derived from the infective larval stage). Particularly promising results have been obtained using the hidden gut antigen H11, or H110D, and more recently with another hidden antigen, H-gal-GP. The use of a natural antigen vaccine, however, would provide advantages such as boosting of the immune response by field challenge. This article will review recent developments in both types of vaccines against H. contortus and consider the advantages and disadvantages of the 2 approaches.
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Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000737:chemistry / Q000276:immunology*; D001315:Australia; D004064:Digestive System; D018432:Drug Resistance, Multiple; D006188:Haemonchiasis / Q000517:prevention & control*; D006189:Haemonchus / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013019:South Africa; D014611:Vaccination
D000947:Antigens, Helminth