title: Selective IgA deficiency and anaphylactoid transfusion reaction: a case report.
abstract: Anaphylactoid transfusion reaction following the administration of incompatible blood products can be life threatening, but accounts for only a very small proportion of all transfusion reactions. One of the causes of anaphylactoid transfusion reaction is the reaction of patient's anti-immunoglobulin A(IgA) with plasma IgA which is usually present in transfused blood. We report a case who had anaphylactoid transfusion reactions after transfusion of only a few milliliters of packed RBC from 3 consecutive donors, in spite of compatible pretransfusion crossmatches. The patient's serum revealed IgA deficiency accompanied by high-titer anti-IgA. The family study showed that one of her sons had partial IgA deficiency accompanied by anti-IgA2. In conclusion, although selective IgA deficiency is rare in Taiwan, it may still occasionally result in severe anaphylactoid transfusion reactions.
authors.affiliation: Section of Medical Oncology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: C H
authors.initials: CH
authors.lastname: Wei
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.forename: R K
authors.initials: RK
authors.lastname: Hsieh
authors.forename: C H
authors.initials: CH
authors.lastname: Tzeng
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Fan
authors.forename: T J
authors.initials: TJ
authors.lastname: Chiou
authors.forename: P M
authors.initials: PM
authors.lastname: Chen
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000150:complications* / Q000235:genetics; D007070:Immunoglobulin A / Q000276:immunology; D010375:Pedigree; D065227:Transfusion Reaction
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A