Short protocol of gonadotropin releasing hormone agonist administration gave better results in long protocol poor-responders in IVF-ET.
OBJECTIVE
To determine the effectiveness of a short protocol (SP) of gonadotropin-releasing hormone agonist (GnRH-a) administration in patients who already had undergone at least one in vitro fertilization (IVF) and embryo transfer (ET) treatment cycle with the long protocol (LP) and had shown poor results.


METHODS
One hundred and twelve patients were studied. The E2 levels, the number of preovulatory follicles, the number of oocytes retrieved and fertilized, the number of embryos cleaved, the fertilization rate and the number of embryos transferred were calculated.


RESULTS
The values for the mentioned parameters were significantly higher in the SP than those in the LP. So were the pregnancy rates per cycle and per ET (23.2% and 24.1%, respectively) in the SP significantly (p < 0.0001) higher than those in the LP (12.5% and 13.5%, respectively).


CONCLUSIONS
In cases who showed poor results to the LP, instead of repeating the same protocol the SP may be substituted. This strategy may not only improve the results, but also decrease the total cost of the IVF-ET treatment.
Taşdemir
M
M
Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan.
Taşdemir
I
I
Kodama
H
H
Fukuda
J
J
Tanaka
T
T
D000328:Adult; D002064:Buserelin / Q000008:administration & dosage*; D002985:Clinical Protocols; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D011247:Pregnancy; D016896:Treatment Outcome
D007987:Gonadotropin-Releasing Hormone; D002064:Buserelin