Phitsanulok population: the highest incidence of hemoglobin E in the northern provinces of Thailand and PND counseling.
Phitsanulok is a province situated in the southern part of northern Thailand. Studies of hemoglobinopathies of 2,806 individuals during the period 1988-1990 showed an overall incidence of hemoglobinopathies of 38.89%, with HbE as high as 25% which is the highest incidence of HbE in the North of Thailand. Buddhachinaraj Hospital conducted a maternal screening study on 1,015 pregnant women in 1991 as part of a prevention/control program and found that 22.56% (229 women) had hemoglobinopathies. Of those, 102 (44.54%) individuals (83.33% HbE heterozygotes and 8.82% HbE homozygotes) with their spouses participated in a prenatal diagnosis (PND) counseling program; 100% of the females and 96% of the male were willing to accept PND; 71% of the females and 75.6% of the males had no moral objection in PND.
Pravatmuang
P
P
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tiloklurs
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M
Suannum
M
M
Chaipat
C
C
D005260:Female; D006580:Genetic Carrier Screening; D005817:Genetic Counseling; D005843:Geography; D007722:Health Knowledge, Attitudes, Practice; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000453:epidemiology* / Q000517:prevention & control; D006456:Hemoglobinuria / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control*; D006720:Homozygote; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening; D009014:Morals; D011247:Pregnancy; D011795:Surveys and Questionnaires; D013785:Thailand / Q000453:epidemiology; D017086:beta-Thalassemia / Q000453:epidemiology / Q000517:prevention & control
D006446:Hemoglobin E