Searching for a marker for Alzheimer's disease-Apo-E.
The authors present their study of 10 patients affected by Alzheimer's disease and 10 patients with multinfarctual dementia, who are already part of a CNR study, senile dementia project, longitudinal study. The method adopted was that of DNA crossbreeding and amplification, so as to have a precise individualisation of alleles APo-E, Apo E-3, Apo E-4 and of their various phenotype combinations. These isoforms are evaluated and compared with the disease studied, in order to help to identify a timely-marker for senile dementia. On the results obtained we hypothesised an association between Apo E-4 and the disease of about 40% for Alzheimer's disease, which leads us to increase our number of cases, regarding associations between demential diseases either Alzheimer or vascular and the presence of Apo E-4.
Venarucci
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INRCA-Department of Biochemistry, Fermo Ancona, Italy.
Catalini
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Venarucci
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Casado
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D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D004247:DNA / Q000097:blood / Q000235:genetics; D015161:Dementia, Multi-Infarct / Q000097:blood / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies
D001057:Apolipoproteins E; D015415:Biomarkers; D004247:DNA