title: Histamine in human epidermal cells is induced by ultraviolet light injury.
abstract: Human epidermal cell cultures were examined to determine whether they were capable of histamine release. Results of these studies indicated that keratinocytes contain and release significant amounts of histamine. In the skin of some individuals, histamine content was induced after ultraviolet B light injury, and 40% of subjects demonstrated high basal histamine levels. Mass spectrometric analysis of cell supernatants showed that the histamine was released into the extracellular environment. Such release may contribute to common itching or intensify the inflammatory response in vivo.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: R
authors.initials: R
authors.lastname: Malaviya
authors.forename: A R
authors.initials: AR
authors.lastname: Morrison
authors.forename: A P
authors.initials: AP
authors.lastname: Pentland
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D003872:Dermatitis / Q000209:etiology; D006632:Histamine / Q000032:analysis*; D006636:Histamine Release / Q000528:radiation effects; D006801:Humans; D015603:Keratinocytes / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D006632:Histamine