Characterization of nitrosation products in cosmetics raw materials by liquid chromatography/mass spectrometry techniques.
Characterization of nitrosation products in cosmetics raw material samples has been accomplished by three liquid chromatography/mass spectrometry (LC/MS) techniques. Two of the techniques involved conventional methodologies of LC/MS and LC/tandem mass spectrometry, both of which can be used to detect and identify products formed under extreme-nitrosation conditions. The third technique utilized an on-line coupling of a photolysis reactor with the LC/MS, and it may be used as a rapid and specific means of screening for the presence of known and unknown N-nitrosamines, which may be carcinogenic.
Volmer
D A
DA
Food and Drug Administration, National Center for Toxicological Rsearch, Jefferson, AR 72079, USA.
Lay
J O
JO
Billedeau
M
M
Vollmer
D L
DL
D010129:4-Aminobenzoic Acid / Q000032:analysis / Q000737:chemistry; D002853:Chromatography, Liquid; D003358:Cosmetics / Q000032:analysis / Q000737:chemistry*; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D009603:Nitroso Compounds / Q000032:analysis / Q000737:chemistry*; D010782:Photolysis; D062366:para-Aminobenzoates
D003358:Cosmetics; D007202:Indicators and Reagents; D009603:Nitroso Compounds; D062366:para-Aminobenzoates; D010129:4-Aminobenzoic Acid; C041981:padimate-O