title: The diagnosis and management of gastroesophageal reflux disease.
abstract: GERD is a common clinical problem. Generally, its clinical presentation and management are straightforward. Greater awareness of the numerous extraesophageal manifestations of the disease aids patients and physicians in appropriate recognition and treatment. Medical therapy is effective in the majority of cases but often requires long-term medication for acceptable symptom control. A small, but significant proportion of patients presents with or develops complications of GERD, most importantly Barrett's esophagus. Although the logistics of long-term surveillance of persons with Barrett's esophagus is unclear, the association of this metaplastic change with esophageal adenocarcinoma underscores the importance of regular follow-up.
authors.affiliation: Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Weinberg
authors.forename: S L
authors.initials: SL
authors.lastname: Kadish
mesh_terms: D001471:Barrett Esophagus; D004942:Esophagitis, Peptic; D004945:Esophagoscopy; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008329:Managed Care Programs; D012017:Referral and Consultation