Regulation of chemokine gene expression by contact hypersensitivity and by oral tolerance.
In mice with hapten-induced CH, T cells of the CD4+ and CD8+ phenotypes activated the gene for JE, whereas CD8+ T cells alone caused activation of the gene for IP-10. In animals tolerized by feeding either TNCB or OX, hapten-induced expression of IP-10 but not JE mRNA was lost. The down-regulation of IP-10 gene activation was adoptively transferred from tolerized mice to naive mice by CD4+ splenic T cells. These findings reflect the differential roles of individual T-cell subsets in both enhancing and diminishing chemokine gene expression in contact hypersensitivity reactions.
Yuan
Y S
YS
Department of Biology, Cleveland State University, Ohio 44195, USA.
Major
J A
JA
Battisto
J R
JR
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018925:Chemokines / Q000096:biosynthesis*; D003877:Dermatitis, Contact; D004423:Ear; D005786:Gene Expression Regulation / Q000276:immunology*; D006241:Haptens; D007108:Immune Tolerance; D051379:Mice; D010081:Oxazolone / Q000008:administration & dosage / Q000276:immunology*; D010853:Picryl Chloride / Q000008:administration & dosage / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D012867:Skin / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D015533:Transcriptional Activation
D018925:Chemokines; D006241:Haptens; D012333:RNA, Messenger; D010081:Oxazolone; D010853:Picryl Chloride