Pulmonary toxicity following exposure to an aerosolized leather protector.
BACKGROUND
An aerosol spray for leather protection was reformulated to remove trichloroethane. The new formulation contained isobutane, n-heptane, ethyl acetate and fluoroaliphatics.
Thirty-nine patients reported symptoms to the regional poison center. Respiratory symptoms developed within hours of exposure. Most symptoms resolved within two days. Abnormal pulmonary function tests, including obstructive disease or diminished diffusing capacity, were demonstrated in three of the four tested patients.


CONCLUSIONS
The mechanism for the pulmonary toxicity has not been determined.
Burkhart
K K
KK
Center for Emergency Medical Services, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, USA.
Britt
A
A
Petrini
G
G
O'Donnell
S
S
Donovan
J W
JW
D000085:Acetates / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D002073:Butanes / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects*; D006536:Heptanes / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008171:Lung Diseases / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged
D000085:Acetates; D000336:Aerosols; D002073:Butanes; D005466:Fluorocarbons; D006536:Heptanes; C007650:ethyl acetate