Molecular cloning and sequence analysis of the chick melanocortin 1-receptor gene.
The chick melanocortin 1-receptor gene was isolated. It is found to be an intronless gene encoding a 314 amino acid protein, sharing 64% identity with mammalian counterparts. A cis-element responsible for melanocyte-specific transcription is found in its 5' upstream region. It is probable that the expression of the receptor in melanocytes is closely correlated with that of melanogenesis-related genes.
Takeuchi
S
S
Department of Biology, Faculty of Science, Okayama University, Japan. stakevoh@cc.okayama-u.ac.jp
Suzuki
S
S
Hirose
S
S
Yabuuchi
M
M
Sato
C
C
Yamamoto
H
H
Takahashi
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002642:Chick Embryo; D003001:Cloning, Molecular; D004247:DNA; D017931:DNA Primers; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D011979:Receptors, Pituitary Hormone / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D017931:DNA Primers; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D009074:Melanocyte-Stimulating Hormones; D004247:DNA