Current status of structure-activity relationships of platinum anticancer drugs: activation of the trans geometry.
Farrell
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Department of Chemistry, Virginia Commonwealth University, Richmond 23284-2006, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity*; D001665:Binding Sites; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage; D004261:DNA Replication / Q000187:drug effects; D005260:Female; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D008961:Models, Structural; D009690:Nucleic Acid Conformation; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; C034697:transplatin; D004247:DNA; D002945:Cisplatin