[The effect of copper on immune responses in guinea pigs with experimental ascariasis].
A subchronic effect of copper on selected immunological parameters was studied in guinea pigs with experimental ascariosis (Ascaris suum). CuSO4 given orally for 28 days moderately increased T and B cells in the animal lymphoid organs. CH50 and AH50 complement levels remained unchanged during CuSO4 administration. A subsequent infection of subchronically intoxicated guinea pigs caused a repeated insignificant stimulation of B cell values while the percentage of T cells was not increased. On the contrary, the complement levels increased significantly in intoxicated infected animals, namely CH50 levels from day 5 to day 15 and AH50 levels from day 1 to day 7 post infection. No statistically significant differences were observed in comparison with infected non-intoxicated guinea pigs. The lean intensity of infection evoked by A. suum larvae migrating in the lungs of intoxicated animals was 29% lower than in control.
Borosková
Z
Z
Institute of Parasitology, Slovak Academy of Sciences, Kosice, Slovak Republic.
Soltýs
J
J
Benková
M
M
D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D001196:Ascariasis / Q000276:immunology*; D017165:Ascaris suum / Q000276:immunology; D003167:Complement Activation; D003300:Copper / Q000494:pharmacology* / Q000506:poisoning; D019327:Copper Sulfate; D006168:Guinea Pigs; D007111:Immunity, Cellular
D000909:Antibodies, Helminth; D003300:Copper; D019327:Copper Sulfate