Quantitative technetium-99M dimercaptosuccinic acid renal scanning in children.
OBJECTIVE
To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA).


METHODS
Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar technique in which not only the appearance but the absolute amount of intravenously administered 99mTc DMSA taken up by the kidneys was calculated for each child and compared with contemporaneous determinations of creatinine clearance.


RESULTS
There was a close correlation between the absolute DMSA uptake and creatinine clearance (r = 0.752).


CONCLUSIONS
Renal function in children, expressed as creatinine clearance, can be accurately estimated by measuring absolute DMSA uptake with planar gamma camera imaging using 99mTc DMSA.
Goodgold
H M
HM
Division of Nuclear Medicine and Urology, St. Louis University Health Sciences Center, Missouri 63110, USA.
Fletcher
J W
JW
Steinhardt
G F
GF
D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D015609:Organotechnetium Compounds; D011237:Predictive Value of Tests; D011866:Radioisotope Renography; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D003404:Creatinine; D004113:Succimer