title: Evaluation of serum concentration of parathyroid hormone-related protein and its implication in hypercalcemia in squamous cell carcinoma of the head and neck.
abstract: Hypercalcemia is a common and serious complication associated with squamous cell carcinoma (SCC) and is considered to be caused by a tumor-derived factor, parathyroid hormone-related protein (PTHrP). However, the correlation between serum levels of calcium and PTHrP and the kinetics of PTHrP in SCC of the head and neck is unknown, because the behavior of the circulating form of PTHrP in patients has not been determined. In the present study, the PTHrP concentrations in serum samples from 54 patients (37 with SCC and 17 with benign tumors) were measured by a recently developed radioimmunoassay directed toward the C-terminal region of PTHrP, and the laboratory data including those calcium levels in corresponding samples were reviewed retrospectively. Results showed hypercalcemia in four patients with advanced cancer and in whom elevation of the serum PTHrP concentration was observed simultaneously. The regression analysis also revealed the linear relationship of the calcium level to the PTHrP concentration, but not to the concentration of phosphorus or creatinine, suggesting that monitoring of serum PTHrP level is useful for prediction of hypercalcemia associated with head and neck cancer.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Rikimaru
authors.forename: F
authors.initials: F
authors.lastname: Matsumoto
authors.forename: E
authors.initials: E
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Bando
authors.forename: M
authors.initials: M
authors.lastname: Nagayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002118:Calcium / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000150:complications; D003404:Creatinine / Q000097:blood; D005260:Female; D005544:Forecasting; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000150:complications; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000209:etiology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D010758:Phosphorus / Q000097:blood; D011506:Proteins / Q000032:analysis* / Q000378:metabolism; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D010758:Phosphorus; D003404:Creatinine; D002118:Calcium