title: Normal changes in the MR appearance of the spleen during early childhood.
abstract: OBJECTIVE
  During the first year of life, the spleen undergoes histologic changes as the lymphoproliferative system matures. The purposes of this study were to describe the normal MR appearance of the spleen during infancy and early childhood and to correlate imaging findings with age-related histologic changes.
  
  
  METHODS
  The spleen was evaluated on 28 abdominal MR studies obtained during the first 23 months of life. Splenic signal intensity was compared to that of the liver. Selected autopsy specimens were compared with the imaging results.
  
  
  RESULTS
  The T2-weighted signal intensity of the spleen gradually increased from isointense to hypointense relative to the liver during the first week of life to moderately hyperintense to the liver by 8 months of age. T1-weighted splenic signal intensity gradually decreased. These findings corresponded to histological increases in white-pulp-red-pulp ratios.
  
  
  CONCLUSIONS
  Before the lymphoid system completely matures, the T2-weighted signal intensity of the normal neonatal spleen appears decreased compared with the moderately hyperintense splenic signal seen in older children and adults. This finding should not be mistaken for disease.
authors.affiliation: Department of Radiology, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Donnelly
authors.forename: K H
authors.initials: KH
authors.lastname: Emery
authors.forename: K E
authors.initials: KE
authors.lastname: Bove
authors.forename: G S
authors.initials: GS
authors.lastname: Bissett
mesh_terms: D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D012016:Reference Values; D013154:Spleen / Q000033:anatomy & histology*