title: Executive system dysfunction in the aged monkey: spatial and object reversal learning.
abstract: As part of the effort to characterize age-related cognitive changes in executive system function in a nonhuman primate model of human aging, the performance of seven rhesus monkeys, 20 to 28 years of age, was compared to that of five young adult monkeys, 6 to 11 years of age, on spatial and object reversal tasks. No differences in performance were found between the two groups in the initial learning of either task. On spatial reversals, aged monkeys were impaired relative to young adults, but there was no difference in overall performance between the groups on object reversals. Central to this article, a perseverative tendency was noted in the aged group on both spatial and object reversal tasks. Changes in executive system dysfunction may represent an important aspect of age-related cognitive decline.
authors.affiliation: Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Lai
authors.forename: M B
authors.initials: MB
authors.lastname: Moss
authors.forename: R J
authors.initials: RJ
authors.lastname: Killiany
authors.forename: D L
authors.initials: DL
authors.lastname: Rosene
authors.forename: J G
authors.initials: JG
authors.lastname: Herndon
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D003071:Cognition / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D007858:Learning / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D013037:Spatial Behavior / Q000502:physiology*