title: Sequential evaluation of portal venous hemodynamics by Doppler ultrasound in patients with severe acute hepatitis.
abstract: OBJECTIVE
  Portal hypertension may develop in patients with severe acute hepatitis. Sequential changes of portal venous hemodynamics in acute hepatitis is not well understood. This study evaluated portal hemodynamic changes and prognostic values in patients with severe, acute hepatitis.
  
  
  METHODS
  Doppler studies, liver function tests, and virology studies were done in the inclusion, the 3rd month, and the 6th month for patients with severe, acute hepatitis. An indocyanine green clearance was done in the inclusion. Doppler portal hemodynamic studies were done in the hilar area by an average of two measurements.
  
  
  RESULTS
  A total of 88 consecutive patients was included. Nine of them died. On initial study, fatalities were generally older patients with more delayed indocyanine green clearance, lower portal vein velocity, lower albumin values, higher bilirubin values, longer prothrombin time, and ascites. Using stepwise logistic regression, portal blood flow and prothrombin time were the two independence prognostic factors. By multiple linear regression, portal blood flow was associated with ascites, and average portal blood velocity was associated with bilirubin. During the hospital days, transient, depressed portal blood velocities followed by a hyperdynamic stage were found in survivors. The portal vein velocity changes for fatalities either were kept at a lower level or had a declining pattern.
  
  
  CONCLUSIONS
  Doppler ultrasound detects portal hemodynamic changes for patients with severe, acute hepatitis. Sequential portal hemodynamic studies will be helpful for evaluating patients with severe, acute hepatitis.
authors.affiliation: Liver Unit, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan, Republic of China.
authors.forename: D
authors.initials: D
authors.lastname: Tai
authors.forename: C S
authors.initials: CS
authors.lastname: Changchien
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
authors.forename: S S
authors.initials: SS
authors.lastname: Chiou
authors.forename: C M
authors.initials: CM
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Kuo
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
authors.forename: K W
authors.initials: KW
authors.lastname: Chiu
authors.forename: S K
authors.initials: SK
authors.lastname: Chuah
authors.forename: T H
authors.initials: TH
authors.lastname: Hu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002353:Carrier State; D005500:Follow-Up Studies; D006439:Hemodynamics; D006525:Hepatitis, Viral, Human / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011379:Prognosis; D012720:Severity of Illness Index; D017741:Survivors; D018608:Ultrasonography, Doppler