Prognostic significance of Ki-67 labeling index in urothelial tumors of the renal pelvis and ureter.
OBJECTIVE
We evaluated the prognostic significance of the Ki-67 labeling index in 70 patients with primary urothelial tumors of the renal pelvis and ureter.


METHODS
Immunohistochemical staining for Ki-67 in archival tumor materials was done by the streptavidin-biotin method.


RESULTS
Univariate survival analysis showed that the prognosis of patients with a high Ki-67 labeling index of 21.7 or more was significantly worse than that of patients with an intermediate labeling index of 13.3 to less than 21.7 (p < 0.01) or a low labeling index of less than 13.3 (p < 0.001). Multivariate survival analysis showed that staining for Ki-67 labeling index was significantly correlated with prognosis (p < 0.01).


CONCLUSIONS
Analysis of Ki-67 labeling index provides useful prognostic information about patients with primary urothelial tumors of the renal pelvis and ureter.
Masuda
M
M
Department of Urology, Yokohama City University School of Medicine, Japan.
Iki
M
M
Takano
Y
Y
Asakura
T
T
Noguchi
S
S
Ikeda
I
I
Kubota
Y
Y
Hosaka
M
M
D000951:Antigens, Neoplasm / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000401:mortality*; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D007680:Kidney Neoplasms / Q000276:immunology / Q000401:mortality*; D007682:Kidney Pelvis / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D014513:Ureter / Q000737:chemistry; D014516:Ureteral Neoplasms / Q000276:immunology / Q000401:mortality*
D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins