title: Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). IGR Breast Cancer Group.
abstract: BACKGROUND
  Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor.
  
  
  METHODS
  Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2, N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis.
  
  
  RESULTS
  Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P < 0.02) or inadequate surgical excisioin (P < 0.02) were significant. No particular risk factors for contralateral tumor development were identified.
  
  
  CONCLUSIONS
  Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.
authors.affiliation: Department of Radiotherapy & Oncology, Ninewells Hospital and Medical School, Dundee, Scotland.
authors.forename: J A
authors.initials: JA
authors.lastname: Dewar
authors.forename: R
authors.initials: R
authors.lastname: Arriagada
authors.forename: S
authors.initials: S
authors.lastname: Benhamou
authors.forename: E
authors.initials: E
authors.lastname: Benhamou
authors.forename: J J
authors.initials: JJ
authors.lastname: Bretel
authors.forename: B
authors.initials: B
authors.lastname: Pellae-Cosset
authors.forename: J L
authors.initials: JL
authors.lastname: Marin
authors.forename: J Y
authors.initials: JY
authors.lastname: Petit
authors.forename: G
authors.initials: G
authors.lastname: Contesso
authors.forename: D
authors.initials: D
authors.lastname: Sarrazin
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D018365:Neoplasm, Residual / Q000473:pathology; D016016:Proportional Hazards Models; D011879:Radiotherapy Dosage; D012044:Regression Analysis; D012307:Risk Factors; D015996:Survival Rate