title: Ockelbo virus (Togaviridae: Alphavirus) neutralizing antibodies in experimentally infected Swedish birds.
abstract: The ability of native Swedish birds to produce and maintain production of Ockelbo virus neutralizing (Nt) antibodies were evaluated experimentally between 6 June 1990 and 27 July 1991. After experimental infection of 57 birds of the orders Anseriformes and Passeriformes with Ockelbo virus, these birds were examined for Ockelbo virus Nt antibodies at 5 days, and at 1, 3, 6, 9, and 12 mo after inoculation. One month after inoculation, Nt antibodies were more prevalent in birds with a detectable viremia (100%, n = 22) than in non-viremic birds (65%, n = 26). The Nt antibody prevalence varied over time among taxa; detectable antibodies occurred earlier after inoculation and for a longer time in Anseriformes than in Passeriformes. By 5 days after inoculation, antibodies could be detected in 22 (71%) of 31 Anseriformes but in none of 16 Passeriformes. However, at 1 mo the antibody prevalences at 1 mo were similar: 84% among the Anseriformes and 73% among the Passeriformes; at 3 mo the prevalences were 50% in Anseriformes and 15% in Passeriformes. Forty-two percent of the Anseriformes had detectable antibodies even 12 mo after inoculation.
authors.affiliation: Virology Unit, Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
authors.forename: J O
authors.initials: JO
authors.lastname: Lundström
authors.forename: B
authors.initials: B
authors.lastname: Niklasson
mesh_terms: D000524:Alphavirus / Q000276:immunology*; D018354:Alphavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001715:Bird Diseases / Q000453:epidemiology / Q000276:immunology*; D001717:Birds; D009500:Neutralization Tests / Q000662:veterinary; D015995:Prevalence; D013548:Sweden / Q000453:epidemiology; D014766:Viremia / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral