Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice.
Transgenic mice whose pancreata express transforming growth factor-beta (TGF-beta) directed by an insulin promoter (Ins-TGF-beta mice) were used to assess the effect of local TGF-beta1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-beta1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-beta1 mice). These results suggest that local TGF-beta1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.
Lee
M S
MS
Department of Neuropharmacology, The Scripps research Insititute, La Jolla, California 92037, USA.
Sawyer
S
S
Arnush
M
M
Krahl
T
T
von Herrath
M
M
Oldstone
M A
MA
Sarvetnick
N
N
D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D006084:Graft Rejection / Q000517:prevention & control*; D008216:Lymphocytic Choriomeningitis / Q000150:complications*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D016035:Pancreas Transplantation / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000494:pharmacology*; D014184:Transplantation, Homologous
D016212:Transforming Growth Factor beta