Prevalence and determinants of glucose intolerance in a Dutch caucasian population. The Hoorn Study.
OBJECTIVE
To study the prevalence and determinants of glucose intolerance in a general Caucasian population.


METHODS
A random sample of 50- to 74-year old Caucasians (n = 2,484) underwent oral glucose tolerance tests. Multiple regression analyses were performed to study the association of 2-h postload plasma glucose values with potential determinants.


RESULTS
Prevalence of known and newly detected diabetes and impaired glucose tolerance was 3.6, 4.8, and 10.3%, respectively. In women, but not in men, the association of body mass index with 2-h glucose was fully accounted for by the waist-to-hip ratio. Maternal history of diabetes was twice as prevalent as paternal history, but paternal history only was associated with 2-h glucose. In addition, paternal history was a stronger determinant in men than in women. An independent positive association with 2-h plasma glucose was found for alcohol use of > 30 g/day in women and for intake of total protein, animal protein, and polyunsaturated fatty acids in men. An independent inverse association with 2-h plasma glucose was demonstrated for height (both sexes), alcohol use of < or = 30 g/day (both sexes), energy intake (in men), and, unexpectedly, current smoking (in men).


CONCLUSIONS
The prevalence of diabetes in elderly Caucasians was 8.3%. In men, dietary habits may unfavorably influence glucose tolerance independent of obesity.
Mooy
J M
JM
Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, the Netherlands. jm.mooy.emgo@med.vu.nl
Grootenhuis
P A
PA
de Vries
H
H
Valkenburg
H A
HA
Bouter
L M
LM
Kostense
P J
PJ
Heine
R J
RJ
D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D003920:Diabetes Mellitus / Q000453:epidemiology; D004032:Diet; D002149:Energy Intake; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D011897:Random Allocation; D012044:Regression Analysis; D012307:Risk Factors; D012727:Sex Characteristics; D012737:Sex Factors; D012907:Smoking; D044465:White People
D001786:Blood Glucose