Mast cell and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis.
Many patients with interstitial cystitis (IC) also have irritable bowel syndrome (IBS), both of which occur overwhelmingly in women, are characterized by pain, and worsen under stress. Bladder and colon biopsies of a female patient with both IC and IBS were evaluated immunohistochemically. There were 40 +/- 10 mast cells (MC)/mm2 (normal, less than 10) in the bladder, which were degranulated. The colon contained 148 +/- 11 MC/mm2 (normal, less than 50), mostly close to numerous substance P (SP)-positive nerves. Histamine, methylhistamine, and the unique MC enzyme tryptase were evaluated in 24-hour urine during two flare-ups. These results may help explain the concurrent presentation and the painful nature of these syndromes.
Pang
X
X
Department of Pharmacology, Experimental Therapeutics, and Urology, Tufts University School of Medicine-New England Medical Center, Boston 02111, USA.
Boucher
W
W
Triadafilopoulos
G
G
Sant
G R
GR
Theoharides
T C
TC
D053818:Chymases; D003106:Colon / Q000294:innervation / Q000473:pathology; D003109:Colonic Diseases, Functional / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018856:Cystitis, Interstitial / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006632:Histamine / Q000652:urine; D006801:Humans; D008407:Mast Cells / Q000201:enzymology / Q000473:pathology*; D008761:Methylhistamines / Q000652:urine; D008875:Middle Aged; D009412:Nerve Fibers / Q000378:metabolism; D012697:Serine Endopeptidases / Q000652:urine; D013373:Substance P / Q000378:metabolism*; D053802:Tryptases; D001743:Urinary Bladder / Q000294:innervation / Q000473:pathology
D008761:Methylhistamines; D013373:Substance P; D006632:Histamine; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases