BCR rearrangement without juxtaposition of ABL in pre-T acute lymphoblastic leukaemia.
The incidence and clinical relevance of the Philadelphia (Ph) translocation t(9:22) (q34:q11) in T-lineage acute lymphoblastic leukaemia (ALL) are unknown. We describe a patient with pre-T-ALL and a clonal 22q-aberration detected by conventional cytogenetics, suggestive of a Ph translocation. However, fluorescence in situ hybridization (FISH) using BCR and ABL probes revealed a translocation with one breakpoint within the BCR gene on chromosome 22 without juxtaposition of ABL on chromosome 9. We discuss the diagnostic and possible pathogenetic implications of this Ph-like chromosomal aberration.
Fosså
A
A
Department of Internal Medicine (Cancer Research), University Hospital of Essen, Germany.
Siebert
R
R
Kasper
C
C
Becher
R
R
Opalka
B
B
Thiel
E
E
Seeber
S
S
Nowrousian
M R
MR
D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D010677:Philadelphia Chromosome; D016133:Polymerase Chain Reaction; D011289:Preleukemia / Q000235:genetics*; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl