Apoptosis amd metastasis: a superior resistance of metastatic cancer cells to programmed cell death.
We studied the response to different external signals leading to apoptosis of several poorly and highly metastatic cell lines employing a murine B16 melanoma experimental metastasis model. We found that highly metastatic cells exhibit a superior survival ability and resistance to apoptosis compared to poorly metastatic cells which would give the former an obvious selective growth advantage during tumor progression. Our results indicate that there is a genetic link between aggressive metastatic phenotype and resistance to apoptosis.
Glinsky
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GV
Cancer Research Center and Department of Biochemistry, University of Missouri-Columbia, 65201, USA.
Glinsky
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VV
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D002449:Cell Aggregation; D002470:Cell Survival / Q000235:genetics / Q000502:physiology*; D004273:DNA, Neoplasm / Q000737:chemistry; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology* / Q000556:secondary*; D051379:Mice; D008970:Molecular Weight; D010641:Phenotype; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm