title: Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: a pilot study.
abstract: Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-M0, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m2/day) and cytosine arabinoside (100 mg/m2/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7%) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.
authors.affiliation: Department of Medicine, Jichi Medical School, Tochigi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Iwao
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Hatake
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: S
authors.initials: S
authors.lastname: Hagiwara
authors.forename: H
authors.initials: H
authors.lastname: Tomizuka
authors.forename: R
authors.initials: R
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Furukawa
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D010865:Pilot Projects; D012074:Remission Induction; D012307:Risk Factors; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D003561:Cytarabine; D016190:Carboplatin