A human killer inhibitory receptor specific for HLA-A1,2.
Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.
Döhring
C
C
Basel Institute for Immunology, Switzerland.
Scheidegger
D
D
Samaridis
J
J
Cella
M
M
Colonna
M
M
D000911:Antibodies, Monoclonal / Q000737:chemistry; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D001667:Binding, Competitive / Q000276:immunology; D002999:Clone Cells; D015791:HLA-A3 Antigen / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000276:immunology*; D054340:Receptors, KIR; D054347:Receptors, KIR3DL2; D013601:T-Lymphocytes / Q000378:metabolism
D000911:Antibodies, Monoclonal; D015791:HLA-A3 Antigen; D007074:Immunoglobulin G; C515084:KIR3DL2 protein, human; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054347:Receptors, KIR3DL2