Intraepithelial lymphocytes in colon have similar properties to intraepithelial lymphocytes in small intestine and hepatic intermediate TCR cells.
Recently, properties of intraepithelial lymphocytes (IEL) in the colon (C-IEL) have been analyzed in comparison with those of IEL in the small intestine (SI-IEL). We compared the properties of C-IEL with those of SI-IEL and hepatic intermediate TCR cells, two other types of extrathymic T cells. C-IEL and intermediate TCR cells contain many NK1+T cells, although SI-IEL contain few. V gamma and V delta usage of C-IEL was the same as that SI-IEL, and that of intermediate TCR cells was different. C-IEL responded to Con A while SI-IEL did not. As to adhesion molecules, C-IEL include both extrathymic and thymus-originated type T cells. With age, TCR- alpha beta(+) CD4+ CD8+ cells do not increase among C-IEL but do increase among SI-IEL. IL-2R beta(+) or CD4- CD8- C-IEL increase as observed in the liver. These results indicate that these organ-specific T cells have different roles at their respective sites and that they may be of different lineages.
Ohtsuka
K
K
Department of Immunology, Niigata University School of Medicine, Japan.
Hasegawa
K
K
Yamagiwa
S
S
Sato
K
K
Nakayama
M
M
Watanabe
H
H
Asakura
H
H
Abo
T
T
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001483:Base Sequence; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000276:immunology; D003106:Colon / Q000166:cytology* / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D016130:Immunophenotyping; D007421:Intestine, Small / Q000166:cytology* / Q000276:immunology; D008099:Liver / Q000166:cytology* / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D013047:Specific Pathogen-Free Organisms
D000954:Antigens, Surface; D011948:Receptors, Antigen, T-Cell