title: Effect of stavudine on human immunodeficiency virus type 1 virus load as measured by quantitative mononuclear cell culture, plasma RNA, and immune complex-dissociated antigenemia.
abstract: The antiviral effect of stavudine (2', 3'-didehydro-3'-deoxythymidine) against human immunodeficiency virus (HIV) type 1 was measured in 15 HIV-infected patients at baseline and at weeks 4, 10, 22, 34, and 52 of therapy. Patients received 0.1, 0.5, 1.0, or 2.0 mg/kg/day of stavudine. At all time points examined during the 52 weeks of therapy, the median virus titers in peripheral blood mononuclear cells were decreased 1-2 logs, and median immune complex-dissociated antigen levels were reduced 37%-67% compared with baseline values. Plasma RNA content measured by polymerase chain reaction was reduced approximately 0.5 log from baseline median values at both time points examined (weeks 10 and 52). These data demonstrate that stavudine has a substantial and durable antiviral effect.
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: B P
authors.initials: BP
authors.lastname: Griffith
authors.forename: H
authors.initials: H
authors.lastname: Brett-Smith
authors.forename: G
authors.initials: G
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Mellors
authors.forename: T M
authors.initials: TM
authors.lastname: Chacko
authors.forename: R B
authors.initials: RB
authors.lastname: Garner
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
authors.forename: P
authors.initials: P
authors.lastname: Alcabes
authors.forename: G
authors.initials: G
authors.lastname: Friedland
mesh_terms: D000936:Antigen-Antibody Complex; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002478:Cells, Cultured; D015488:HIV Antigens / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood; D018119:Stavudine / Q000008:administration & dosage* / Q000627:therapeutic use; D014766:Viremia / Q000821:virology
chemical_list: D000936:Antigen-Antibody Complex; D000998:Antiviral Agents; D015488:HIV Antigens; D012367:RNA, Viral; D018119:Stavudine