title: Alpha s1-casein-specific CD8+ T cell clone that inhibits its own interferon-gamma production by producing interleukin-10.
abstract: A CD8+ T cell clone specific to alpha s1-casein, one of the major allergens in milk, is shown to inhibit its own production of interferon (IFN)-gamma by producing interleukin (IL)-10. Anti-IL-10 antibodies enhanced the production of IFN-gamma induced by the antigen plus antigen-presenting cells from 12 h onward after initiating the culture. This enhancing effect was observed only when the cells were stimulated in the presence of the antigen-presenting cells. Neither IL-2 nor IL-4 abrogated this enhancing effect. This reveals a new regulating mechanism for IFN-gamma production from CD8+ T cells.
authors.affiliation: Department of Applied Biological Chemistry, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nishijima
authors.forename: T
authors.initials: T
authors.lastname: Hisatsune
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: O
authors.initials: O
authors.lastname: Shiho
authors.forename: S
authors.initials: S
authors.lastname: Kaminogawa
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000485:Allergens / Q000494:pharmacology*; D000906:Antibodies / Q000494:pharmacology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002364:Caseins / Q000494:pharmacology*; D002460:Cell Line; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000494:pharmacology / Q000502:physiology; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D012680:Sensitivity and Specificity
chemical_list: D000276:Adjuvants, Immunologic; D000485:Allergens; D000906:Antibodies; D002364:Caseins; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma