Three suicide attempts with moclobemide.
OBJECTIVE
To report plasma moclobemide, course and outcome of two cases of overdose with moclobemide alone and one case of combined ingestion of moclobemide and clomipramide.


METHODS
Moclobemide identification and quantification was achieved by gas chromatography-mass spectrometry after alkaline extraction.


METHODS
In case 1, plasma moclobemide was 2.8 mg/L with 1.8 mg/L clomipramide; in case 2, 18 mg/L; in case 3 60.9 mg/L and 4.6 mg/L 12 hours later. None of the patients showed serious effects during 24 hours of observation. Plasma moclobemide at 10 to 30 times therapeutic was not associated with major toxic effects. Moclobemide seems to be considerably less toxic than tricyclic antidepressants.
Iwersen
S
S
University of Hamburg, Germany.
Schmoldt
A
A
D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D001549:Benzamides / Q000097:blood / Q000506:poisoning*; D002997:Clomipramine / Q000506:poisoning; D004347:Drug Interactions; D062787:Drug Overdose; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008875:Middle Aged; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000097:blood / Q000506:poisoning*; D013406:Suicide, Attempted
D000929:Antidepressive Agents, Tricyclic; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D002997:Clomipramine; D020912:Moclobemide