Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3.
It has been described that interleukin 3 (IL3) activates JAK2, which in turn stimulates STAT5 activation. We found, however, that IL3 induces tyrosine-phosphorylation of Tyk2 as well as JAK2 in IL3-dependent mouse cell lines, FDC-P2 and Ba/F3. Furthermore, we found that IL3 induces activation of not only STAT5 but also STAT1 and STAT3. Taken together with other observations, these results indicate that IL3, erythropoietin and thrombopoietin share a common JAK-STAT signaling pathway.
Nagata
Y
Y
Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
Todokoro
K
K
D000818:Animals; D001483:Base Sequence; D002364:Caseins / Q000235:genetics; D002454:Cell Differentiation; D002460:Cell Line; D004247:DNA; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004789:Enzyme Activation; D007377:Interleukin-3 / Q000494:pharmacology*; D051379:Mice; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D002364:Caseins; D004268:DNA-Binding Proteins; D007377:Interleukin-3; D004247:DNA; D011505:Protein-Tyrosine Kinases