[Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice].
In experiments on male mice, the effect of the cholinesterase reactivators obidoxime, methoxime and HI-6 in combination with atropine sulfate on the acute intoxication with the organophosphorous insecticide fosdrine was tested in dependence on the period of administration of drugs after intoxication and on the dose of oxime by influencing the LD50 value in 48-hour survival of experimental animals. It has been demonstrated that the rate of the therapeutic intervention is a much more important factor influencing the effect of oximes than the dose of oximes. A shortening of the period of drug administration from 2 minutes to 30 seconds substantially increases the effects of all three oximes. A comparison of the effects of all three reactivators has shown that the oxime HI-6 is significantly more effective than the remaining two reactivators in the case of therapy of intoxication 30 seconds after the application of the noxa. In the therapy of intoxication 2 minutes after the exposure of experimental animals to fosdrine, the effect of the antidotal therapy was relatively low regardless of the selected oxime.
Kassa
J
J
Vojenská lékarská akademie JEP, Hradec Králové.
Bajgar
J
J
D000208:Acute Disease; D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008799:Mevinphos / Q000506:poisoning*; D051379:Mice; D009768:Obidoxime Chloride / Q000627:therapeutic use; D010091:Oximes / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy; D011726:Pyridinium Compounds / Q000627:therapeutic use
D002801:Cholinesterase Reactivators; D007306:Insecticides; D010091:Oximes; D011726:Pyridinium Compounds; D009768:Obidoxime Chloride; C005514:N,N'-monomethylenebis(pyridiniumaldoxime); D008799:Mevinphos; D001285:Atropine; C022870:asoxime chloride