title: Mitral valve repair is superior to valve replacement for the early preservation of cardiac function: relation of ventricular geometry to function.
abstract: The immediate effect or mitral valve repair (MVP) or replacement (MVR) on cardiac function was compared in patients with mitral regurgitation in relation to the changes in left ventricular (LV) function and geometry by using intraoperative transesophageal echocardiography in 29 patients with MVP and 21 patients with MVR, before and immediately after cardiopulmonary bypass. The LV volumes, ejection fraction, and long-axis and short-axis lengths and eccentricity index (ratio of long axis to short axis) at end-systole and end-diastole were measured. After both MVP and MVR, there were significant decreases in LV end-diastolic volume (p < 0.0001). However, the ejection fraction did not change after MVP, whereas it decreased after MVR (p < 0.0001). After MVP, there was an increase in eccentricity index at end-systole (p < 0.0001). After MVR, there was no decrease in end-systolic volume, and the eccentricity index was lower than that after MVP (p < 0.0001). The change in LV ejection fraction correlated with the changes in eccentricity index at end-systole (r = 0.55; p < 0.0001) and end-diastole (r = 0.42; p < 0.0003). Immediate intraoperative LV function is preserved after MVP but is depressed after MVR for mitral regurgitation. The changes in ejection fraction correlate with changes in ventricular geometry.
authors.affiliation: Philadelphia Heart Institute, Presbyterian Medical Center, PA, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Ren
authors.forename: S
authors.initials: S
authors.lastname: Aksut
authors.forename: G W
authors.initials: GW
authors.lastname: Lighty
authors.forename: G J
authors.initials: GJ
authors.lastname: Vigilante
authors.forename: J D
authors.initials: JD
authors.lastname: Sink
authors.forename: B L
authors.initials: BL
authors.lastname: Segal
authors.forename: W C
authors.initials: WC
authors.lastname: Hargrove
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D000075202:Contraindications; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery*; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000601:surgery*