Effect of vitamin E on the anticoagulant response to warfarin.
To clarify whether vitamin E enhances the pharmacologic effect of warfarin, we completed a double-blind clinical trial in which 21 subjects taking chronic warfarin therapy were randomized to receive either vitamin E or placebo. None of the subjects who received vitamin E had a significant change in the international normalized ratio, and thus it appears that vitamin E can safely be given to patients who require chronic warfarin therapy.
Kim
J M
JM
Department of Medicine, University of California, Davis, Sacramento, California, USA.
White
R H
RH
D000925:Anticoagulants / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D000075202:Contraindications; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D014810:Vitamin E / Q000494:pharmacology*; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D000975:Antioxidants; D014810:Vitamin E; D014859:Warfarin