title: Intra-abdominal patterns of disease dissemination in colorectal cancer identified using radioimmunoguided surgery.
abstract: OBJECTIVE
  Patterns of metastatic spread are difficult to determine with routine postoperative follow-up. This study was undertaken to evaluate two selected populations of colorectal cancer patients injected and screened with anti-tumor antibody.
  
  
  METHODS
  Eighty-six evaluable patients with colorectal cancer underwent exploratory laparotomy with both traditional surgical exploration and radioimmunoguided surgery (RIGS) following injection of 125I-labeled CC49 monoclonal antibody. RIGS-positive tissue detectable with a handheld gamma-detecting probe was defined as tissue involved with the disease process. Comparisons were made between extent of disease using traditional exploration and extent using RIGS.
  
  
  RESULTS
  In 41 patients with primary disease, traditional exploration detected 45 sites of disease (1.1 sites/patient) compared with 153 RIGS-positive sites (3.7 sites/patient). In 45 patients with recurrent disease, traditional exploration found 116 sites (2.6 sites/patient) vs. 184 RIGS-positive sites (4.1 sites/patient). Involvement by selected anatomic sites is shown below [Table: see text].
  
  
  CONCLUSIONS
  RIGS detected more tissue involved in disease process for all sites in both primary and recurrent disease except liver metastases. Areas with highest proportion of RIGS-positive tissue, the gastrohepatic ligament and celiac nodes, are rarely resected and are not pathologically examined. Positive RIGS localization of tumor antigen in these areas suggests more extensive dissemination of disease process.
authors.affiliation: Division of General Surgery, Department of Surgery, The Ohio State University, Columbus, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Arnold
authors.forename: C L
authors.initials: CL
authors.lastname: Hitchcock
authors.forename: D C
authors.initials: DC
authors.lastname: Young
authors.forename: W E
authors.initials: WE
authors.lastname: Burak
authors.forename: D J
authors.initials: DJ
authors.lastname: Bertsch
authors.forename: E W
authors.initials: EW
authors.lastname: Martin
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D007457:Iodine Radioisotopes; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D016719:Radioimmunodetection
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; C091202:B72.3 antibody; D007457:Iodine Radioisotopes