Sodium beta-artelinate--a new potential gametocytocide.
The water-soluble artemisinin analogue sodium beta-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malaria Plasmodium cynomolgi B, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes. The compound was able to sterilize the circulating gametocytes in rhesus monkey, resulting in loss of mosquito infectivity and oocyst development in the Anopheles stephensi. However, no sporontocidal action has been observed with this compound.
Tripathi
R
R
Division of Microbiology, Central Drug Research Institute, Lucknow, India.
Puri
S K
SK
Dutta
G P
GP
D000284:Administration, Oral; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D037621:Artemisinins; D009033:Culicidae / Q000469:parasitology; D007275:Injections, Intravenous; D007303:Insect Vectors / Q000469:parasitology; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D016789:Plasmodium cynomolgi / Q000187:drug effects* / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C062768:artelinic acid