title: Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives.
abstract: 3'-Azido-2',3'-dideoxyuridines 6 and their corresponding alpha anomers 5 were synthesized by condensation of silylated 6-alkyl and 5,6-dialkyl substituted uracils 2 with methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-alpha, beta-D-erythro-pentofuranoside (4). Compounds 5 and 6 were treated with tetrabutylammonium fluoride to obtain the deprotected nucleosides 7 and 8, respectively.
authors.affiliation: Department of Chemistry, Odense University, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Larsen
authors.forename: K
authors.initials: K
authors.lastname: Danel
authors.forename: G B
authors.initials: GB
authors.lastname: Vaaben
authors.forename: A A
authors.initials: AA
authors.lastname: el-Emam
authors.forename: E B
authors.initials: EB
authors.lastname: Pedersen
authors.forename: C
authors.initials: C
authors.lastname: Nielsen
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000998:Antiviral Agents; C061818:1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine; D015215:Zidovudine; C058803:3'-azido-2',3'-dideoxyuridine; D013941:Thymine