[Reversible tooth discoloration during oral use of antibiotics].
From January 1991 until June 1995. 25 cases were reported to the Netherlands Pharmacovigilance Foundation LAREB of yellow to brown tooth discoloration following the oral use of medication; 21 cases (84%) involved antibiotics, of which 14 were amoxicillin. 17/21 patients were children, with ages ranging from 1 to 10 years. All children used liquid formulations (suspension or solutabs). Discoloration was reversible in all cases, but had a protracted course in some. Presumably a pigment precipitated on (and not in) the teeth, but the nature of the pigment was uncertain.
Meyboom
R H
RH
Stichting Landelijke Registratie Evaluatie Bijwerkingen, Tilburg.
Verduijn
M M
MM
Steenvoorden
M G
MG
Dekens-Konter
J A
JA
van Puijenbroek
E P
EP
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013535:Suspensions; D014075:Tooth Discoloration / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D013535:Suspensions