A randomized, double-blind, placebo-controlled study of the safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients.
Johnson
E M
EM
Department of Surgery, University of Minnesota, Minneapolis 55455, USA.
Zimmerman
J
J
Duderstadt
K
K
Chambers
J
J
Sorenson
A L
AL
Granger
D K
DK
Almond
P S
PS
Fryer
J p
Jp
Leventhal
J R
JR
Scarola
J
J
Matas
A J
AJ
Canafax
D M
DM
D000284:Administration, Oral; D016572:Cyclosporine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006261:Headache; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010919:Placebos; D011090:Polyenes / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D020123:Sirolimus
D007166:Immunosuppressive Agents; D010919:Placebos; D011090:Polyenes; D016572:Cyclosporine; D020123:Sirolimus