Teething and acute graft vs. host disease: a clinical observation.
A 5-month-old girl, treated with bone marrow transplantation for severe combined immunodeficiency, developed two episodes of severe acute graft vs. host disease (GVHD) while teething. A dramatic improvement in GVHD was noted after the completion of tooth eruption. It is suggested that the release of interleukin-1, associated with the traumatized gingival tissue, is the triggering mediator for the GVHD.
Shapira
J
J
Department of Pediatric Dentistry, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
Aker
M
M
Nagler
A
A
Or
R
R
Kapelushnik
J
J
D000208:Acute Disease; D016026:Bone Marrow Transplantation; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005881:Gingiva / Q000276:immunology / Q000293:injuries / Q000378:metabolism; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007375:Interleukin-1 / Q000096:biosynthesis*; D016511:Severe Combined Immunodeficiency / Q000628:therapy; D014078:Tooth Eruption / Q000276:immunology*
D007166:Immunosuppressive Agents; D007375:Interleukin-1; D016572:Cyclosporine