title: Gonadoblastoma in patient with Turner's syndrome.
abstract: A 15-year-old phenotypic female referred for the investigation of primary ammenorrhea, was found to have a 45,XO karyotype and an ovarian cyst. She demonstrated some of the features of Turner's syndrome, as well as virilization. On laparotomy, she was found to have bilateral gonadoblastomas. She was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. Subsequently, repeated chromosomal analysis detected the presence of Y chromosomes, which was confirmed by the use of polymerase chain reaction (PCR). The difficulties encountered in searching for the Y chromosome in patients with gonadoblastoma are discussed. Prophylactic gonadectomy is suggested in those cases associated with atypical features.
authors.affiliation: Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: K W
authors.initials: KW
authors.lastname: Lo
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
authors.forename: T H
authors.initials: TH
authors.lastname: Cheung
authors.forename: S P
authors.initials: SP
authors.lastname: Wong
authors.forename: A
authors.initials: A
authors.lastname: Chang
authors.forename: J H
authors.initials: JH
authors.lastname: Chow
mesh_terms: D000293:Adolescent; D005260:Female; D018238:Gonadoblastoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology