Redox control of gene expression involving iron-sulfur proteins. Change of oxidation-state or assembly/disassembly of Fe-S clusters?
Attention is drawn to a mechanism of redox control of gene expression involving Fe-S proteins which depends on the disassembly and reassembly of Fe-S clusters rather than a change in oxidation state. Iron Regulatory Protein (IRP)/aconitase and FNR are discussed as examples for such a mechanism.
Beinert
H
H
Institute for Enzyme Research, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706, USA.
Kiley
P
P
D000154:Aconitate Hydratase / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D029968:Escherichia coli Proteins; D005786:Gene Expression Regulation / Q000502:physiology*; D007506:Iron-Sulfur Proteins / Q000096:biosynthesis / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C060704:FNR protein, E coli; D007506:Iron-Sulfur Proteins; D000154:Aconitate Hydratase; D010100:Oxygen