Constituent analysis may permit improved diagnosis of intra-abdominal abscess.
BACKGROUND
Intra-abdominal abscesses (IAA) often fail to resolve with intravenous antibiotics alone and frequently require drainage. Diagnosis of IAA in postoperative patients with other likely sources of infection is very difficult.


METHODS
In order to characterize IAA and identify parameters that might facilitate diagnosis, we prospectively examined peripheral blood and pus of 15 consecutive patients with IAA and compared them to samples from 34 consecutive patients with soft-tissue abscesses (STA).


RESULTS
Serum interleukin (IL)-10 was elevated in IAA patients, while abnormally detectable serum IL-4 was demonstrated in the pus of both IAA and STA patients. IL-10 in IAA pus was more than 11-fold higher than in STA, whereas IL-4 in pus was similar in both types of abscesses. Both IL-4 and IL-10 were 4- to 10-fold higher in IAA and STA pus than in corresponding patient serum. Serum lysozyme was, however, significantly elevated in all abscess patients.


CONCLUSIONS
The presence of IL-4 and IL-10 may indicate a T-helper 2 lymphocyte response in the etiology of abscess formation and persistence, although precise determination of T-helper 1-related cytokines is needed to verify this. Serum lysozyme and IL-10 may be reliable and relatively inexpensive diagnostic aids.
Galandiuk
S
S
The Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Kentucky, USA.
Gardner
S A
SA
Heinzelmann
M
M
D018784:Abdominal Abscess / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D009113:Muramidase / Q000097:blood; D011446:Prospective Studies
D015415:Biomarkers; D016753:Interleukin-10; D015847:Interleukin-4; D003165:Complement System Proteins; D009113:Muramidase