Assays for insulin-like growth factors and their binding proteins: practicalities and pitfalls.
Insulin-like growth factors (IGFs) are growth hormone-dependent anabolic peptides that circulate in biologic fluids complexed to a family of IGF binding proteins. Measurement of the serum concentrations of IGF peptides and IGF binding proteins has proved to be an effective means of evaluating functional growth hormone status and makes it possible to establish a diagnosis of IGF deficiency.
Rosenfeld
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RG
Department of Pediatrics, Oregon Health Sciences University, Portland 97062, USA.
Gargosky
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SE
D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D006130:Growth Disorders / Q000175:diagnosis* / Q000188:drug therapy; D013006:Growth Hormone / Q000172:deficiency; D013007:Growth Hormone-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D011863:Radioimmunoassay; D013002:Somatomedins / Q000032:analysis* / Q000502:physiology
D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone