Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration.
The distribution of the putative anti-addictive substance ibogaine was measured in plasma, brain, kidney, liver and fat after ip and sc administration in rats. One hr after ip dosing (40 mg/kg), drug levels ranged from 106 ng/ml (plasma) to 11,308 ng/g (fat), with significantly higher values after sc administration of the same dose. Drug levels were 10-20 fold lower 12 hr after the same dose. These results suggest that: 1) ibogaine is subject to a substantial "first pass" effect after ip dosing, demonstrated by higher drug levels following the sc route, 2) ibogaine shows a large accumulation in adipose tissue, consistent with its lipophilic nature, and 3) persistence of the drug in fat may contribute to a long duration of action.
Hough
L B
LB
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA.
Pearl
S M
SM
Glick
S D
SD
D000818:Animals; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006213:Hallucinogens / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007050:Ibogaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007263:Infusions, Parenteral; D007279:Injections, Subcutaneous; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D006213:Hallucinogens; D007050:Ibogaine