Group 5 allergens of timothy grass (Phl p 5) bear cross-reacting T cell epitopes with group 1 allergens of rye grass (Lol p 1).
Selected human T cell clones reactive with group 5 allergens of timothy grass (Phl p 5) were cross-stimulated in specific proliferation assays with group 1 allergens of rye grass (Lol p 1). Such interspecies cross-reactivities result obviously from structural motifs presented on defined Phl p 5 fragments as shown with recombinant Phl p 5 products.
Müller
W D
WD
Institut für Klinische Immunologie, Friedrich-Schiller-Universität, Jena, Germany.
Karamfilov
T
T
Bufe
A
A
Fahlbush
B
B
Wolf
I
I
Jäger
L
L
D000485:Allergens / Q000235:genetics / Q000276:immunology*; D000595:Amino Acid Sequence; D052179:Antigens, Plant; D003429:Cross Reactions; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008129:Lolium / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics / Q000276:immunology; D006109:Poaceae / Q000235:genetics / Q000276:immunology*; D011058:Pollen / Q000235:genetics / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D052179:Antigens, Plant; D018984:Epitopes, T-Lymphocyte; C042814:Lol p I protein, Lolium perenne; C076049:Phl p V protein, Phleum pratense; D010940:Plant Proteins