Serum antibody responses of cattle following experimental infection with Escherichia coli O157:H7.
Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals developed neutralizing antibodies to verotoxin 2. These serological responses were not correlated with elimination of infection in calves or steers or protection of calves against reinfection with the same strain.
Johnson
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RP
Health of Animals Laboratory, Agriculture and Agri-Food Canada, Guelph, Ontario, Canada. johnsonr@em.agr.ca
Cray
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WC
Johnson
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D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000276:immunology; D002003:Brucella abortus / Q000276:immunology; D002417:Cattle; D003429:Cross Reactions; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology* / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D009500:Neutralization Tests; D022622:Shiga Toxin 1; D022641:Shiga Toxin 2
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D008070:Lipopolysaccharides; D022622:Shiga Toxin 1; D022641:Shiga Toxin 2