title: Pulmonary veno-occlusive disease in a HIV-infected intravenous drug abuser.
abstract: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. Its origin remains unknown but in some cases a viral aetiology has been suggested. Recently primary pulmonary hypertension has been increasingly observed in patients with human immunodeficiency virus (HIV) infection, but only one case of pulmonary veno-occlusive disease has so far been described. We report the case of a 27 year old male intravenous drug abuser with HIV infection and pulmonary hypertension. Open lung biopsy led to the diagnosis of pulmonary veno-occlusive disease. This second case of pulmonary veno-occlusive disease raises the question of a relationship between HIV infection and lesions involving the pulmonary veins. However, the pathogenesis of vascular changes remains to be elucidated.
authors.affiliation: Service de Pneumo-Allergologie, Toulouse, France.
authors.forename: R
authors.initials: R
authors.lastname: Escamilla
authors.forename: C
authors.initials: C
authors.lastname: Hermant
authors.forename: J
authors.initials: J
authors.lastname: Berjaud
authors.forename: C
authors.initials: C
authors.lastname: Mazerolles
authors.forename: X
authors.initials: X
authors.lastname: Daussy
mesh_terms: D000328:Adult; D001706:Biopsy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008297:Male; D011667:Pulmonary Veins / Q000473:pathology; D011668:Pulmonary Veno-Occlusive Disease / Q000209:etiology* / Q000473:pathology; D015819:Substance Abuse, Intravenous / Q000150:complications*