High-performance liquid chromatographic determination of bisacodyl in pharmaceutical dosage forms marketed in Australia.
HPLC methods have been developed for the assay of bisacodyl in various pharmaceutical forms. The extraction procedures are simple and the HPLC conditions separate bisacodyl from its degradation products. The chromatography was performed using a Merck LiChrospher RP-select B column, a mobile phase of 55% acetonitrile/45% 0.05 M KH2PO4 and detection by UV at 214 nm.
Bradshaw
K M
KM
Pharmaceutical Chemistry Section, Therapeutic Goods Administration Laboratories, Woden, Australia.
Burnett
J
J
Sidhu
A S
AS
D001726:Bisacodyl / Q000032:analysis*; D002400:Cathartics / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D012680:Sensitivity and Specificity; D013488:Suppositories / Q000032:analysis; D013607:Tablets / Q000032:analysis
D002400:Cathartics; D013488:Suppositories; D013607:Tablets; D001726:Bisacodyl