title: [Comparison of the effects of fenticonazole and econazole on the aspartic proteinase secreted by Candida albicans].
abstract: In this note, the effect of fenticonazole on secretory aspartic proteinase of the human opportunistic fungus Candida albicans is shown, in a comparison with econazole. Both antigenic and enzymatic assays demonstrate that fenticonazole, in contrast to econazole, greatly reduces the production of the virulence enzyme by stationary-phase C. albicans. This inhibitory effect was specific and was not mediated by the inhibition of fungal growth. These results confirm fenticonazole's unique property, already shown in previous studies.
authors.affiliation: Laboratoire de Bactériologie et de Mycologie Médicale, Institut Supérieur de la Santé, Rome, Italie.
authors.forename: F
authors.initials: F
authors.lastname: De Bernardis
authors.forename: A
authors.initials: A
authors.lastname: Cassone
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D016282:Aspartic Acid Endopeptidases / Q000187:drug effects* / Q000378:metabolism*; D002176:Candida albicans / Q000201:enzymology*; D004353:Drug Evaluation, Preclinical; D004464:Econazole / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D004464:Econazole; D016282:Aspartic Acid Endopeptidases; C033486:fenticonazole