Granulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosis.
We report the development of soft tissue granulocytic sarcoma with megakaryoblastic differentiation in a patient with chronic idiopathic myelofibrosis, which has hitherto been undescribed. Although an artifactual signet ring appearance of the blasts was found in the formalin-fixed tissue and caused diagnostic problems, the histological appearance on B-5 fixed material and immunophenotyping confirmed the diagnosis. Cytogenetic analysis showed 47,XY,+der(1)del(1)(?p13) at initial presentation and 47,XY,del(1)(?13),+der(1)del(1)(?p13) at the time of soft tissue blastic transformation, indicating that partial trisomy 1 might be of pathogenetic significance.
Chan
A C
AC
Department of Pathology, Queen Mary Hospital, Hong Kong.
Kwong
Y L
YL
Lam
C C
CC
D000273:Adipose Tissue / Q000473:pathology; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000150:complications / Q000473:pathology*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000473:pathology*