title: Neuron-specific enolase is increased after single seizures during inpatient video/EEG monitoring.
abstract: Neuron-specific enolase (NSE) is a marker of brain injury after acute neurologic insults. We report changes in serum NSE (s-NSE) in 25 patients (15 with epilepsy and 10 patients with nonepileptic events) during continuous inpatient video/EEG monitoring. s-NSE was significantly increased as compared with baseline and normal controls after the first ictal event in the epileptic group, especially in patients with secondarily generalized tonic-clonic seizures (p = 0.01), but s-NSE was not increased in patients with nonepileptic events. These preliminary data indicate that s-NSE may be increased after complex partial seizures--and generalized tonic-clonic seizures (GTCS).
authors.affiliation: Epilepsy Center, USC University Hospital, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Rabinowicz
authors.forename: J
authors.initials: J
authors.lastname: Correale
authors.forename: R B
authors.initials: RB
authors.lastname: Boutros
authors.forename: W T
authors.initials: WT
authors.lastname: Couldwell
authors.forename: C W
authors.initials: CW
authors.lastname: Henderson
authors.forename: C M
authors.initials: CM
authors.lastname: DeGiorgio
mesh_terms: D000328:Adult; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis / Q000201:enzymology*; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000201:enzymology; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis / Q000201:enzymology; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011602:Psychophysiologic Disorders / Q000175:diagnosis / Q000201:enzymology; D014743:Videotape Recording
chemical_list: D010751:Phosphopyruvate Hydratase