title: Primary Epstein-Barr virus-related non-Hodgkin's lymphoma of the pleural cavity following long-standing tuberculous empyema.
abstract: Primary non-Hodgkin's lymphomas of the pleural cavity have been described mostly in Japan. We report a case of high-grade non-Hodgkin's lymphoma (immunoblastic type) of the pleural cavity occurring in a nonimmunocompromised patient 55 years after an artificial pneumothorax was performed for the treatment of pulmonary tuberculosis. Immunohistochemical study revealed a B phenotype (CD20), and an in situ hybridization detected small nuclear RNAs encoded by Epstein-Barr virus in most lymphomatous cells. A link between primary pleural lymphoma and the local long-standing chronic inflammation, inducing a clonal transformation of Epstein-Barr virus-infected immortalized B lymphocytes, is suspected.
authors.affiliation: Service d' Anatomie Pathologique, Hopital Louis Mourier Colombes, France.
authors.forename: V
authors.initials: V
authors.lastname: Molinie
authors.forename: J
authors.initials: J
authors.lastname: Pouchot
authors.forename: E
authors.initials: E
authors.lastname: Navratil
authors.forename: F
authors.initials: F
authors.lastname: Aubert
authors.forename: P
authors.initials: P
authors.lastname: Vinceneux
authors.forename: J
authors.initials: J
authors.lastname: Barge
mesh_terms: D000368:Aged; D004654:Empyema, Tuberculous / Q000209:etiology* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008297:Male; D010997:Pleural Neoplasms / Q000209:etiology* / Q000473:pathology / Q000821:virology; D011031:Pneumothorax, Artificial / Q000009:adverse effects*; D012367:RNA, Viral / Q000302:isolation & purification; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000601:surgery*
chemical_list: D012367:RNA, Viral