KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats.
A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 molecule between amino acids 406 and 570 in a region containing cysteine-rich repeats.
Stephens
P
P
Celltech Ltd., Slough, England.
Romer
J T
JT
Spitali
M
M
Shock
A
A
Ortlepp
S
S
Figdor
C G
CG
Robinson
M K
MK
D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology*; D000918:Antibody Specificity; D015153:Blotting, Western; D018821:CD18 Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D002448:Cell Adhesion / Q000276:immunology*; D002460:Cell Line / Q000502:physiology; D003545:Cysteine / Q000032:analysis / Q000235:genetics*; D018604:Epitope Mapping; D015870:Gene Expression / Q000235:genetics / Q000276:immunology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D013997:Time Factors
D000911:Antibodies, Monoclonal; D018821:CD18 Antigens; D011993:Recombinant Fusion Proteins; D003545:Cysteine