[The action of medichronal (glucose-glycine-formate) on the serotonin blood level in alcoholism patients].
The effects of a novel antialcoholic medication medichronal on the serotonine concentration in blood of patients with second stage alcoholism was investigated. It has been discovered that remission in 75% of the patients was connected with its hyper- and hyposerotoninemic influence, depending on the initial lowered or increased serotonine content. Similarity of medichronal and unithiol effects was observed in the form of palyndromoinversion regulation of serotoninergic activity. In a portion of the patients the increased, compared to healthy persons, serotonine concentration before and after the treatment does not differ from the average values in the whole group.
Bozhko
G Kh
GKh
Voloshin
P V
PV
Kostiukovskaia
L S
LS
Markozova
L M
LM
Bolotova
Z N
ZN
D000079:Acetaldehyde / Q000037:antagonists & inhibitors*; D000328:Adult; D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation; D005561:Formates / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D005998:Glycine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000097:blood*; D014494:Unithiol / Q000627:therapeutic use
D000427:Alcohol Deterrents; D004338:Drug Combinations; D005561:Formates; C088648:medikhronal; D012701:Serotonin; D014494:Unithiol; D000079:Acetaldehyde; D005947:Glucose; D005998:Glycine