title: High frequency of celiac disease in Down syndrome.
abstract: We screened 115 children with Down syndrome for celiac disease, using antigliadin, antiendomysium, and antireticulin serum antibodies and an intestinal permeability test. Celiac disease was diagnosed in eight children, giving a frequency of 7.0%. We recommend screening for celiac disease in all persons with Down syndrome, with the use of at least the antiendomysium antibody determination.
authors.affiliation: Department of Pediatrics, University Hospital Leiden, The Netherlands.
authors.forename: E K
authors.initials: EK
authors.lastname: George
authors.forename: M L
authors.initials: ML
authors.lastname: Mearin
authors.forename: J
authors.initials: J
authors.lastname: Bouquet
authors.forename: B M
authors.initials: BM
authors.lastname: von Blomberg
authors.forename: S O
authors.initials: SO
authors.lastname: Stapel
authors.forename: R M
authors.initials: RM
authors.lastname: van Elburg
authors.forename: E A
authors.initials: EA
authors.lastname: de Graaf
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D008297:Male; D009426:Netherlands; D012155:Reticulin / Q000276:immunology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D012155:Reticulin; D005903:Gliadin