MR velocity mapping measurement of renal artery blood flow in patients with impaired kidney function.
Renal blood flow (RBF) was measured in 9 patients with chronic impaired kidney function using MR velocity mapping and compared to PAH clearance and 99mTc-DTPA scintigraphy. An image plane suitable for flow measurement perpendicular to the renal arteries was chosen from 2-dimensional MR angiography. MR velocity mapping was performed in both renal arteries using an ECG-triggered gradient echo pulse sequence previously validated in normal volunteers. Effective renal plasma flow was calculated from the clearance rate of PAH during constant infusion and the split of renal function was evaluated by 99mTc-DTPA scintigraphy. A reduction of RBF was found, and there was a significant correlation between PAH clearance multiplied by 1/(1-hematocrit) and RBF determined by MR velocity mapping. Furthermore, a significant correlation between the distribution of renal function and the percent distribution of RBF was found.
Cortsen
M
M
Danish Research Center of Magnetic Resonance, University Hospital, Hvidovre, Denmark.
Petersen
L J
LJ
Ståhlberg
F
F
Thomsen
C
C
Søndergaard
L
L
Petersen
J R
JR
Ladefoged
S D
SD
Henriksen
O
O
D000368:Aged; D001783:Blood Flow Velocity; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000503:physiopathology; D018810:Magnetic Resonance Angiography / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011866:Radioisotope Renography / Q000379:methods; D012077:Renal Artery / Q000473:pathology*; D012079:Renal Circulation; D016284:Technetium Tc 99m Pentetate; D010130:p-Aminohippuric Acid
D002860:Chromium Radioisotopes; D004492:Edetic Acid; D016284:Technetium Tc 99m Pentetate; D010130:p-Aminohippuric Acid