title: Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease.
abstract: Acute splenic sequestration, a well recognized complication of the various sickle cell syndromes, is characterized by increasing splenomegaly and a sudden fall in hemoglobin concentration. In this article, the authors describe a 21-year-old woman with previously undiagnosed hemoglobin SC disease whose initial presentation was that of acute, severe splenic sequestration. Despite the severity of her illness, prompt diagnosis and appropriate therapy led to a complete recovery. The splenic sequestration in this case was apparently exacerbated by a recent hepatitis B infection. To date, this presentation of hemoglobin SC disease has not been described in the medical literature.
authors.affiliation: Department of Medicine, University of California at San Diego Medical Center, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Shao
authors.forename: E P
authors.initials: EP
authors.lastname: Orringer
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006450:Hemoglobin SC Disease / Q000175:diagnosis* / Q000628:therapy; D006454:Hemoglobins / Q000378:metabolism; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology* / Q000628:therapy; D006435:Renal Dialysis; D013163:Splenomegaly / Q000209:etiology*
chemical_list: D006454:Hemoglobins