Thalidomide responsive chronic pulmonary GVHD.
A 29-year-old male underwent allogeneic bone marrow transplantation for progressive multiple myeloma. His post-transplant course was complicated by severe chronic pulmonary graft-versus-host disease (GVHD) resistant to cyclosporin A, corticosteroids and azathioprine. The introduction of thalidomide resulted in a dramatic improvement in his lung function which has been maintained even after cessation of thalidomide. He remains well 40 months after transplantation.
Forsyth
C J
CJ
Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Cremer
P D
PD
Torzillo
P
P
Iland
H J
HJ
Young
G A
GA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001989:Bronchiolitis Obliterans / Q000188:drug therapy* / Q000209:etiology; D016572:Cyclosporine / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009101:Multiple Myeloma / Q000628:therapy*; D013792:Thalidomide / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D013792:Thalidomide; D016572:Cyclosporine