title: Tc-99m sestamibi cardiac SPECT imaging during coronary artery occlusion in humans: comparison with dipyridamole stress studies.
abstract: OBJECTIVE
  To compare the magnitude of change in regional myocardial perfusion during dipyridamole stress with that during coronary occlusion.
  
  
  METHODS
  The authors prospectively studied 14 men with more than 50% diameter stenosis in at least one major coronary artery. Same-day rest and dipyridamole technetium-99m sestamibi single photon emission computed tomography (SPECT) was performed 24 hours before coronary angioplasty. During angioplasty, while the vessel was occluded, 15 mCi(555 MBq) of tracer was injected, and SPECT studies were obtained 60 minutes later. Extent of regional perfusion abnormalities was estimated.
  
  
  RESULTS
  Regional perfusion defect was greater during stress and occlusion than during rest (20%, P = .001 and 14%, P = .009, respectively). SPECT defect during coronary occlusion was similar to that obtained during pharmacologic stress with dipyridamole (53% vs 47%, P = .02).
  
  
  CONCLUSIONS
  Tc-99m sestamibi SPECT with dipyridamole stress is a good predictor of the extent of perfusion abnormalities that occur during coronary occlusion and may facilitate estimation of the total myocardium in jeopardy from a stenotic lesion.
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: S
authors.initials: S
authors.lastname: Borges-Neto
authors.forename: J E
authors.initials: JE
authors.lastname: Watson
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects; D004176:Dipyridamole; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012146:Rest; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi