Endothelin-1 expression in serum and bronchoalveolar lavage from patients with active Behçet's disease.
In view of the pulmonary manifestations in Behçet's disease (BD), we investigated the production of endothelin-1 (ET-1) by the respiratory tract in active BD. A group of 10 patients with active BD with pulmonary manifestations and 10 control subjects were studied. Immunoreactive ET-1 was measured in BAL and in serum by RIA. All the BD patients exhibited higher BAL ET-1 levels than controls. ET-1 expression may contribute to the functional and morphological abnormalities of the vasculature associate with BD.
Hamzaoui
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A
Department of Respiratory Diseases, Faculty of Medicine of Tunis, Tunisia.
Hamzaoui
K
K
Chabbou
A
A
Ayed
K
K
D000328:Adult; D001528:Behcet Syndrome / Q000097:blood / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D016232:Endothelins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
D016232:Endothelins