Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.
The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.
Heinze-Krauss
I
I
F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Angehrn
P
P
Guerry
P
P
Hebeisen
P
P
Hubschwerlen
C
C
Kompis
I
I
Page
M G
MG
Richter
H G
HG
Runtz
V
V
Stalder
H
H
Weiss
U
U
Wei
C C
CC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013210:Staphylococcus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D002511:Cephalosporins