Is there an unidentified defence mechanism against infection in human plasma?
The total peroxyl radical scavenging capacity (TRAP) of human plasma was measured from pneumonia patients and controls. TRAP and its main components, ascorbic acid, alpha-tocopherol, uric acid or protein thiol groups, were unaltered, but the concentration of unidentified antioxidants in pneumonia patients was significantly reduced. Our results indicate that human plasma may contain so far unidentified antioxidants depleted in infection.
Aejmelaeus
R
R
Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical School, University of Tampere, Finland.
Metsä-Ketelä
T
T
Laippala
P
P
Alho
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000097:blood; D002444:Cefuroxime / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010400:Penicillin G / Q000494:pharmacology / Q000627:therapeutic use; D011014:Pneumonia / Q000097:blood* / Q000188:drug therapy; D016897:Respiratory Burst; D013438:Sulfhydryl Compounds / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D016166:Free Radical Scavengers; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D014527:Uric Acid; D002444:Cefuroxime; D001205:Ascorbic Acid; D010400:Penicillin G