Human herpesvirus-6-associated exanthema in a patient with acute lymphocytic leukaemia.
We report the first case of human herpesvirus-6 (HHV-6) associated exanthema in a patient with acute lymphocytic leukaemia (ALL). We analysed DNA extracted from an exanthematous lesion using the polymerase chain reaction (PCR). DNA was positive for HHV-6 but negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus. Immunohistochemical staining of the skin with monoclonal antibody against (HHV-6 confirmed the infection. The possibility of HHV-6 infection should be considered when an atypical skin rash is seen in patients with ALL.
Fujita
H
H
Department of Haematology / Chemotherapy, Clinical Research Institute, Kanagawa Cancer Centre, Yokohama, Japan.
Maruta
A
A
Tomita
N
N
Taguchi
J
J
Sakai
R
R
Shimizu
A
A
Harada
M
M
Ogawa
K
K
Kodama
F
F
Okubo
T
T
D000328:Adult; D005077:Exanthema Subitum / Q000150:complications*; D015654:Herpesvirus 6, Human; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012874:Skin Diseases, Infectious / Q000150:complications*