Activin A inhibits growth and hexamethylene bisacetamide-induced differentiation in human retinoblastoma Y-79 cells.
Activin regulates the growth and differentiation of a variety of cells and is a member of the transforming growth factor-beta (TGF-beta) family. Previously, we found that the retinoblastoma cell line Y-79 expresses both activins and activin receptors, suggesting that activin may have an autocrine function in these cells. In this study, the effects of exogeneous activin A on cultured Y-79 cells were examined. The results demonstrate that activin A inhibits hexamethylene bisacetamide (HMBA) -induced Y-79 cell differentiation in both serum-containing and serum-free medium. Activin A also inhibits Y-79 cell growth in serum-containing medium but not in serum-free medium.
Zhang
Z
Z
Department of Cell and Neurobiology, School of Medicine, University of Southern California, Los Angeles 90033, USA.
Batres
Y
Y
Ying
S Y
SY
D000081:Acetamides / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D028341:Activins; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D016895:Culture Media, Serum-Free; D004347:Drug Interactions; D006801:Humans; D007265:Inhibins / Q000494:pharmacology*; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology*; D014407:Tumor Cells, Cultured
D000081:Acetamides; D000970:Antineoplastic Agents; D016895:Culture Media, Serum-Free; D028341:Activins; D007265:Inhibins; C014026:hexamethylene bisacetamide