A new liposomal contrast medium for CT of the liver. An imaging study in a rabbit tumour model.
A new type of liposomal liver-specific contrast medium was studied in an experimental tumour model. Rabbits were inoculated with VX2-carcinoma directly in the liver of laparotomy. CT studies were carried out 14 days after inoculation. The liver-specific contrast medium consisted of a suspension of liposomes in a 100 mg I/ml iodixanol solution, with equal amounts of encapsulated and nonencapsulated iodixanol. It was administered at a dose of 200 mg I/kg. The contrast of normal liver tissue to tumorous tissue was significantly increased by contrast medium administration, the increase being largest 10 min after injection.
Leander
P
P
Department of Experimental Research. Malmö University Hospital, Sweden.
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D008081:Liposomes; D008099:Liver / Q000000981:diagnostic imaging*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging*; D009368:Neoplasm Transplantation; D011817:Rabbits; D018709:Statistics, Nonparametric; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000706:statistics & numerical data; D014283:Triiodobenzoic Acids / Q000008:administration & dosage*
D003287:Contrast Media; D004337:Drug Carriers; D008081:Liposomes; D014283:Triiodobenzoic Acids; C044834:iodixanol