Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants.
OBJECTIVE
To determine the relationships among complements, other serum proteins (including acute-phase reactant), and the cytokine interleukin-6.


METHODS
Prospective observational study.


METHODS
A perinatal center, children's hospital, and research institute in Osaka, Japan.


METHODS
Two hundred fifteen newborn infants ranging from 17 to 42 weeks in gestational age.


METHODS
We measured the serum levels of several proteins and complements in the cord blood of neonates with and without chorioamnionitis by immunological assays.


RESULTS
The levels of C3d, haptoglobin, interleukin-6, IgM, C-reactive protein, and IgA were not influenced by gestational age, and levels of C5, C1q, C2, albumin, C9, and IgG were not influenced by chorioamnionitis status. The levels of C3, C4, CH50, factor B, and orosomucoid were influenced by both factors.


CONCLUSIONS
Our investigation of the mutual relation of the data suggests that the increase of cytokine interleukin-6 affects each other component. We suggest that, compared with the serum levels of proteins in neonates with chorioamnionitis, levels in neonates without chorioamnionitis are more similar to those in the normal fetus.
Miyano
A
A
Department of Laboratory Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
Miyamichi
T
T
Nakayama
M
M
Kitajima
H
H
Shimizu
A
A
D001798:Blood Proteins / Q000032:analysis*; D002821:Chorioamnionitis / Q000097:blood*; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies
D001798:Blood Proteins; D015850:Interleukin-6; D003165:Complement System Proteins