title: Pyoderma gangrenosum in a patient with cryoglobulinemia and hepatitis C successfully treated with interferon alfa.
abstract: We describe a patient with long-standing pyoderma gangrenosum unresponsive to therapy. The patient had concomitant cryoglobulinemia and hepatitis C. When the hepatitis C was treated with interferon alfa-2a his pyoderma gangrenosum resolved. Whether this was from the interferon alfa or spontaneous resolution is not known.
authors.affiliation: Division of Dermatology, University of South Florida College of Medicine, Tampa 33612-4799, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Smith
authors.forename: P D
authors.initials: PD
authors.lastname: Shenefelt
authors.forename: O
authors.initials: O
authors.lastname: Soto
authors.forename: J
authors.initials: J
authors.lastname: Valeriano
mesh_terms: D000328:Adult; D003449:Cryoglobulinemia / Q000150:complications*; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000473:pathology / Q000628:therapy*; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins