title: Enhanced magnetic resonance imaging and subtraction techniques in postoperative evaluation of craniofacial resection for sinonasal malignancy.
abstract: The use of magnetic resonance imaging (MRI) enhanced with gadolinium. and diethylenetriamine pentaacetic acid (DTPA) in the preoperative evaluation of sinonasal malignancy is well established and has an accuracy of over 98%. Since 1979, 208 patients have undergone craniofacial resection at London's Institute of Laryngology & Otology, primarily for sinonasal neoplasia affecting the anterior skull base. Thirty-five "high-risk" patients had MRI at follow-up. The MRI scans were assessed before the patients were examined under anesthesia. MRI was assessed before examination under anesthesia and the results compared with histologic findings demonstrating a reasonable degree of positive correlation but one which is inferior to that found preoperatively (80%). An extension of this technique using the subtraction of T1-weighted MRI with Gd-DTPA highlights areas of increased vascularity, which significantly improves the ability to predict recurrence at the skull base and above the surgical repair in the anterior cranial fossa (94%).
authors.affiliation: Institute of Laryngology and Otology, London, England.
authors.forename: V J
authors.initials: VJ
authors.lastname: Lund
authors.forename: G A
authors.initials: GA
authors.lastname: Lloyd
authors.forename: D J
authors.initials: DJ
authors.lastname: Howard
authors.forename: A D
authors.initials: AD
authors.lastname: Cheesman
authors.forename: P D
authors.initials: PD
authors.lastname: Phelps
mesh_terms: D000328:Adult; D000368:Aged; D005147:Facial Bones / Q000473:pathology / Q000601:surgery*; D005260:Female; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000601:surgery*; D004369:Pentetic Acid; D011184:Postoperative Period; D012189:Retrospective Studies; D012886:Skull / Q000473:pathology / Q000601:surgery*; D013382:Subtraction Technique
chemical_list: D004369:Pentetic Acid; D005682:Gadolinium