Molecular therapies for vascular diseases.
Vascular disease is the most common cause of death in the industrialized world. Although significant progress has been made in treating these disorders, more therapeutic agents must be developed that effectively prevent, arrest, or reverse this disease. Recent insights into the pathogenesis of vascular disease have opened up a new frontier of molecular therapies that target molecules as diverse as adhesion molecules and transcription factors. The biological rationale for these new therapies and their prospects for success are discussed.
Gibbons
G H
GH
Falk Cardiovascular Research Center, Stanford University School of Medicine, CA 94305-5246, USA.
Dzau
V J
VJ
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D002450:Cell Communication; D016923:Cell Death; D002455:Cell Division; D004198:Disease Susceptibility; D004730:Endothelium, Vascular / Q000503:physiopathology; D005109:Extracellular Matrix / Q000502:physiology; D005818:Genetic Engineering; D015316:Genetic Therapy; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000473:pathology; D018384:Oxidative Stress; D014680:Veins / Q000637:transplantation