title: Effects of medial septal lesions on an operant go/no-go delayed response alternation task in rats.
abstract: Previous work in our laboratory has found that whereas medial septal lesions impaired an operant left-right delayed alternation task in rats, the lesion also facilitated the performance of rats on a cued go/no-go discrimination task with a delay between the cue and the required response. These findings suggested to us that the medial septal lesions impaired "response" working memory, which in turn led to a compensatory enhancement of attention to stimulus cues. If this hypothesis is true, then the lesions should impair a go/no-go task based on "response" working memory. The current experiment tested this hypothesis. Rats (12 with medial septal lesions and 12 with sham operations) were tested on a discrete trial operant go/no-go response alternation task. The rats were first tested for 20 days without a delay contingency, followed by 35 days of testing with a 15-s delay between "go" and "no-go" trials. Both groups became proficient at the task under nondelay conditions and their terminal performance (averaging about 85% correct) did not differ. However, under delay conditions the performance of the lesioned rats was significantly impaired compared to the controls. As the go/no-go task does not require a spatial discrimination, the best explanation for our findings is that the lesions impaired response working memory.
authors.affiliation: Department of Psychology, Santa Clara University, CA 95053, USA.
authors.forename: R
authors.initials: R
authors.lastname: Numan
authors.forename: M P
authors.initials: MP
authors.lastname: Feloney
authors.forename: K H
authors.initials: KH
authors.lastname: Pham
authors.forename: L M
authors.initials: LM
authors.lastname: Tieber
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D012686:Septal Nuclei / Q000502:physiology*; D013647:Task Performance and Analysis