title: Histological findings of human leprosy periapical granulomas.
abstract: Histological analysis of human leprosy periapical granulomas was conducted to study the histological responses to Mycobacterium leprae. Many Langhans-type giant cells and epithelioid cell tubercles were observed, although M. leprae were not detected in leprosy periapical granulomas. Although numerous T- and B-cells were infiltrated in leprosy periapical granuloma, the T-/B-cell ratio of leprosy is not changed to that of periapical granulomas isolated from normal patients. These findings suggested that human leprosy periapical granulomas develop as a result of immunological responses to M. leprae.
authors.affiliation: Department of Endodontics, Kanagawa Dental College, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tani-Ishii
authors.forename: T
authors.initials: T
authors.lastname: Osada
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Umemoto
mesh_terms: D001402:B-Lymphocytes; D015622:Epithelioid Cells; D015744:Giant Cells, Langhans; D006801:Humans; D007918:Leprosy / Q000150:complications*; D009166:Mycobacterium leprae / Q000276:immunology*; D010484:Periapical Granuloma / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013601:T-Lymphocytes