Prediction of complications in gamma knife radiosurgery of arteriovenous malformation.
The incidence of complications following radiosurgical treatment of arteriovenous malformations (AVM) is presented. A simple relationship exists between average dose and risk of complications, and on this basis a model is presented that gives a qualitatively correct description of this relationship. The parameters of the model have been determined using a clinical material of 862 AVM treatments to give a quantitatively correct description of the risk of complications. The dose-response curve is described by a double-exponential function. An accurate description of the dose-response curve at high dose levels is shown to be very important in radiosurgery.
Lax
I
I
Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden.
Karlsson
B
B
D000465:Algorithms; D001921:Brain / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008959:Models, Neurological; D015233:Models, Statistical; D011336:Probability; D011832:Radiation Injuries / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects*; D011880:Radiotherapy Planning, Computer-Assisted