title: [Resistance of Mycobacterium tuberculosis in the province of Castellón].
abstract: We conduced a cross-sectional study to determine the prevalence of resistant mycobacteria in our setting. All patients in whom M. tuberculosis had been isolated in cultures of clinical samples (119) between January 1992 and December 1993 took part in the study. Canetti's method of percentages was used for the study of sensitivity to the following drugs: isocyanide, rifampicin, streptomycin, ethambutol and para-aminosalicylic acid. Overall resistance of M. tuberculosis was 9.24%. Specifically, we found resistance to isocyanide in 5.9%, to streptomycin in 4.20%, to rifampicin in 5.04% and to ethambutol in 1.68%. Resistance was primary in 7% and secondary in 21.05%; 2% showed primary resistance to isocyanide, 1% to isocyanide and rifampicin, 2% to streptomycin, 1% to ethambutol and 1% to streptomycin and rifampicin. These resistance indices are in keeping with those published for other areas of Spain.
authors.affiliation: Servicio de Microbiología, Hospital General de Castellón.
authors.forename: R
authors.initials: R
authors.lastname: Moreno
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: F
authors.initials: F
authors.lastname: Pardo
authors.forename: J
authors.initials: J
authors.lastname: Andrés Soler
authors.forename: P L
authors.initials: PL
authors.lastname: Prada Alfaro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004352:Drug Resistance, Microbial; D004977:Ethambutol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology; D013030:Spain; D013307:Streptomycin / Q000494:pharmacology
chemical_list: D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin