Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis.
OBJECTIVE
The urine protein and glycosaminoglycan (GAG) excretion of normal cats was compared with that of cats suffering from interstitial cystitis (IC), which is reported to decrease urine GAG excretion in humans.


METHODS
Total urine GAG concentration was measured in random and 24-hour urine specimens by spectrophotometry by 1,9-dimethylmethylene blue (DMB) chloride.


RESULTS
In both random and 24-hour urine samples, GAG and protein concentrations and GAG:creatinine and protein:creatinine ratios all were significantly lower in cats with IC. Total GAG and protein excretion also were significantly lower in 24-hour urine samples from cats with IC.


CONCLUSIONS
GAG excretion was decreased in cats with IC, as it is in humans. It is unclear whether this is due to changes in synthesis, metabolism, or bladder permeability.
Buffington
C A
CA
Department of Veterinary Clinical Sciences, Ohio State University, Columbus, 43210, USA.
Blaisdell
J L
JL
Binns
S P
SP
Woodworth
B E
BE
D000818:Animals; D002415:Cats; D003404:Creatinine / Q000652:urine; D018856:Cystitis, Interstitial / Q000175:diagnosis / Q000652:urine*; D003558:Cystoscopy; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D008297:Male; D011507:Proteinuria / Q000378:metabolism
D006025:Glycosaminoglycans; D003404:Creatinine