Is the height/plasma creatinine formula of Schwartz useful as a screening test in detecting Nigeria children with low GFR?
A group of 42 children with renal diseases seen at the University College Hospital Ibadan were studied in order to evaluate the usefulness of the height/plasma creatinine formula of Schwartz et al i.e. GFR ml/min/1.73 m2 = 0.55 x Height (cm)/Plasma creatinine (mg/dl) in identifying children with renal impairment. The children were divided into 2 groups of those with GFR as measured by endogenous creatinine clearance (Ccr) < 60 ml/min/1.73 cm2 and those with CCr > 60 ml/min/1.73 cm2. There were 21 children in each group. In detecting patients with Ccr less than 60 ml/min/1.73 m2, Schwartz formula had a sensitivity of 52%, a specificity of 100%, a positive predictive value of 100% and a negative predictive value of 68%. It is concluded that in detecting patients with impaired renal function who may need more accurate methods of estimating GFR, Schwartz formula has a low sensitivity and therefore may not be useful as a screening method.
Gbadegesin
R A
RA
Department of Paediatrics, University College Hospital, Ibadan Nigeria.
Asinobi
A O
AO
Osinusi
K
K
Adeyemo
A A
AA
D001827:Body Height / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis*; D008297:Male; D009549:Nigeria; D012680:Sensitivity and Specificity
D003404:Creatinine