Hormonal imprinting: neonatal treatment of rats with the peroxysome proliferator clofibrate irreversibly affects sexual behaviour.
In the rat, the peroxysome proliferator activated receptor (PPAR) inducer clofibrate can moderately influence the hormone (testosterone) level and, after single perinatal treatment, irreversibly affects sexual behavior through the mechanism of hormonal imprinting. The thymic glucocorticoid and estrogen receptors weren't significantly influenced. The experiments call the attention to the universality of false imprinting by molecules able to bind to the steroid/thyroid receptor superfamily, and point to the different sensitivity to different ligands.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
Karabélyos
C
C
Pap
E
E
D000818:Animals; D000831:Animals, Newborn; D002994:Clofibrate / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects*; D012737:Sex Factors; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood; D014157:Transcription Factors / Q000187:drug effects*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D013739:Testosterone; D011374:Progesterone; D002994:Clofibrate