Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia and pretreatment measurement of tumor oxygenation. The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of <10 mm Hg (P=0.01). There were eight treatment failures; the first site of recurrence was lung in all patients. Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P=0.03). Potential mechanisms and implications for clinical trial design are discussed.
Brizel
D M
DM
Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina, 27710, USA. brizel@radonc.duke.edu
Scully
S P
SP
Harrelson
J M
JM
Layfield
L J
LJ
Bean
J M
JM
Prosnitz
L R
LR
Dewhirst
M W
MW
D015687:Cell Hypoxia; D006801:Humans; D009362:Neoplasm Metastasis; D011237:Predictive Value of Tests; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*