title: Malignant testicular neoplasms in immunosuppressed patients.
abstract: OBJECTIVE
  Testicular cancers were studied in patients on immunosuppression.
  
  
  METHODS
  A retrospective analysis was done of testicular cancer in patients on immunosuppression reported on between 1975 and 1995.
  
  
  RESULTS
  The management schemes adopted in the immunosuppressed population followed the generally accepted management concepts. No patient with low stage (A to B1) disease died of testis cancer. Only 4 of 66 patients (6.1%) with the acquired immunodeficiency syndrome died of testis cancer compared to 5 of 20 (25%) after transplantation, implying significantly higher cause specific mortality in post-transplant patients (Fisher's exact test, p < 0.01). The incidence of adverse effect of therapy did not differ from the expected incidence in other patients.
  
  
  CONCLUSIONS
  Patients on immunosuppression with testicular neoplasms should be treated in the standard fashion as indicated by tumor histology and stage of disease, since most will tolerate therapy and benefit from the standard treatment protocols.
authors.affiliation: Department of Urology, Indiana University Medical Center, Indianapolis, USA.
authors.forename: I
authors.initials: I
authors.lastname: Leibovitch
authors.forename: J
authors.initials: J
authors.lastname: Baniel
authors.forename: R G
authors.initials: RG
authors.lastname: Rowland
authors.forename: E R
authors.initials: ER
authors.lastname: Smith
authors.forename: J K
authors.initials: JK
authors.lastname: Ludlow
authors.forename: J P
authors.initials: JP
authors.lastname: Donohue
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D018237:Germinoma / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D018239:Seminoma / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents