Monoblastic leukemia in an HIV-infected patient: absence of viral expression in RNA blasts.
A small number of patients seropositive for the human immunodeficiency virus (HIV) have been reported as developing acute non-lymphoblastic leukemia (ANLL). In the cases previously published, the authors never reported a study of the link joining HIV infection and leukemia. We describe here the case of a 41-year-old HIV positive patient who developed ANLL (FAB classification M5). Using molecular techniques, we looked for a direct link between these two co-existing diseases. We showed the absence of HIV expression in the malignant clone, suggesting that the association of ANLL and Acquired Immune Deficiency Syndrome is not a direct consequence of the myeloid precursors infection. Nevertheless a relationship may exist through a disorganization of the bone marrow micro-environment.
Guillemain
C
C
Hematology Laboratory, CHU-Conception, Marseille, France.
George
F
F
Courcoul
M
M
Dhiver
C
C
Brunet
C
C
Spire
B
B
Horschowski
N
N
Conciatori
M
M
Sampol
J
J
D000328:Adult; D001853:Bone Marrow / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D005534:Foot Diseases / Q000209:etiology; D015870:Gene Expression; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000821:virology; D008297:Male; D014411:Neoplastic Stem Cells / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000209:etiology; D016047:Zalcitabine / Q000627:therapeutic use; D015215:Zidovudine / Q000627:therapeutic use
D004279:DNA, Viral; D012367:RNA, Viral; D015215:Zidovudine; D016047:Zalcitabine