Studies on dressings for mucosa of the oral cavity. Part 3: Effect of preparation technology on the physical and chemical properties of stomatological xerogel dressings.
Adhesion of xerogel dressings prepared on Eudragit (E), methylcellulose (MC) and glycerol compositions, remaining within the range of 625-650 g, after addition polyvinylpyrolidone (PVP) amounts to 450-1250 g. Dissolution time from xerogel dressings without PVP additive both in water and in an artificial gastric juice amounts to 3 h. Addition of PVP results in reduction of the elution rate. In dependence upon the PVP/E/MC ratio elution time amounts to 3-3.5 h. Pharmaceutical availability of the Kunitz protease inhibitor in particular groups of then dressings depends upon concentration of hydrophilizing agent. The semi-liberation times amounts to 3.65-17.50 h.
Małecka
K
K
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silesian Piasts Memorial Medical Academy, Wrocław, Poland.
Kubis
A
A
D000180:Acrylic Resins / Q000737:chemistry / Q000378:metabolism; D000268:Adhesiveness; D000596:Amino Acids / Q000378:metabolism; D007611:Aprotinin / Q000494:pharmacology; D001458:Bandages; D005750:Gastric Juice; D005782:Gels; D006490:Hemostatics / Q000494:pharmacology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006868:Hydrolysis; D008747:Methylcellulose / Q000737:chemistry / Q000378:metabolism; D009061:Mouth Mucosa / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D011109:Polymethacrylic Acids; D012995:Solubility
D000180:Acrylic Resins; D000596:Amino Acids; D005782:Gels; D006490:Hemostatics; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D008747:Methylcellulose; D007611:Aprotinin