Tolazoline decreases survival time during microwave-induced lethal heat stress in anesthetized rats.
Effects of alpha-adrenergic antagonists have been studied during environmental heating but not during microwave-induced heating. Tolazoline may exert some of its effects via alpha-adrenegic blockade. In the present study, ketamine-anesthetized Sprague-Dawley rats were exposed to 2450-MHz microwaves at an average power density of 60 mW/cm2 (whole-body specific absorption rate of approximately 14 W/kg) until lethal temperatures were attained. The effects of tolazoline (10 mg/kg body weight) on physiological responses (including changes in body temperature, heart rate, blood pressure, and respiratory rate) were examined. Survival time was significantly shorter in the tolazoline group than in saline-treated animals. In general, heart rate and blood pressure responses were similar to those that occur during environmental heat stress. Heart rate, however, was significantly elevated in animals that received tolazoline, both before and during terminal microwave exposure. It is possible that changes associated with the elevated heart rate (e.g., less cardiac filling) in tolazoline-treated animals resulted in greater susceptibility to microwave-induced heating and the lower survival time.
Jauchem
J R
JR
Radiofrequency Radiation Division, Occupational and Environmental Health Directorate, U.S. Air Force Armstrong Laboratory, Brooks Air Force Base, Texas 78235-5324, USA.
Chang
K S
KS
Frei
M R
MR
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008872:Microwaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D014043:Tolazoline / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D007649:Ketamine; D014043:Tolazoline