Familial predisposition to uterine leiomyomas.
OBJECTIVE
To study the clinical risk for gynecological disorders in first-degree relatives in families with uterine leiomyoma.


METHODS
Ninety-seven families (215 female patients) were enrolled in this study; 97 patients and 118 of their near family relatives were examined.


RESULTS
Leiomyoma was discovered in 24.7% of cases, 2.2 times more frequently (P < 0.001) among the first-degree female relatives in families with two or more verified leiomyoma cases. The rate of PCO disease was about 15% for both groups.


CONCLUSIONS
These results confirm the concept of distinct predisposition to uterine leiomyoma and the PCO disease in first-degree relatives in families with leiomyoma accumulation.
Vikhlyaeva
E M
EM
Research Center of Obstetrics, Moscow, Russian Federation.
Khodzhaeva
Z S
ZS
Fantschenko
N D
ND
D000328:Adult; D000368:Aged; D004198:Disease Susceptibility; D005190:Family; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000453:epidemiology / Q000235:genetics*; D008499:Medical Records; D008875:Middle Aged; D010298:Parity; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000235:genetics*