title: Impaired neutrophil chemotaxis after cardiac surgery.
abstract: Chemotaxis of circulating peripheral neutrophils was studied in 12 patients undergoing elective cardiac surgery. Tests of neutrophil chemotaxis were made preoperatively and 16-20 hours postoperatively, using a multipore filter assay. Statistically significant postoperative decrease was demonstrated in both stimulated and random neutrophil migration (p = 0.012 and p = 0.009, respectively). Although the peripheral neutrophil count showed a statistically significant postoperative increase (p = 0.001), the increase did not correlate to the decrease in neutrophil chemotaxis. Nor could correlation be demonstrated between the altered neutrophil chemotaxis and any per- or postoperative variables.
authors.affiliation: Department of Anaesthesiology, Skejby Hospital, University of Aarhus, Denmark.
authors.forename: R H
authors.initials: RH
authors.lastname: Jensen
authors.forename: M
authors.initials: M
authors.lastname: Storgaard
authors.forename: R
authors.initials: R
authors.lastname: Vedelsdal
authors.forename: N
authors.initials: N
authors.lastname: Obel
mesh_terms: D000768:Anesthesia, General; D001021:Aortic Valve / Q000601:surgery; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D001026:Coronary Artery Bypass; D004198:Disease Susceptibility; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008851:Micropore Filters; D008943:Mitral Valve / Q000601:surgery; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000502:physiology*; D013530:Surgical Wound Infection / Q000209:etiology
chemical_list: D009240:N-Formylmethionine Leucyl-Phenylalanine