Omeprazole causes delay in gastric emptying of digestible meals.
We have studied gastric emptying of a solid, realistic meal (800 cal, 15% protein, 45% fat, 40% carbohydrate) in 21 healthy subjects twice, with and without a four-day pretreatment with 40 mg omeprazole. The last dose of the drug was taken 24 hr before the test, to avoid hypothetical nonsecretory side effects of the drug . Gastric emptying was measured by ultrasound of antral diameters. The results show that basal and maximal postprandial antral cross-sectional areas were the same during the two tests. A greater residual distention of the antrum was present throughout the study after the omeprazole treatment, the difference being significant at time 120 and 240. Omeprazole induced a highly significant delay in gastric emptying [control 199.6 (12.6) vs omeprazole 230.9 (12.7) min, mean (1 SEM); P<0.003]. The delay was not due to a prolonged lag phase, but rather to an effect on the slope of the emptying curve. This study shows that in normal subjects omeprazole delays gastric emptying of a digestible solid meal.
Benini
L
L
Department of Gastroenterology, Rehabilitation Hospital of Valeggio sM, University of Verona, Italy.
Castellani
G
G
Bardelli
E
E
Sembenini
C
C
Brentegani
M T
MT
Caliari
S
S
Vantini
I
I
D000328:Adult; D003864:Depression, Chemical; D004063:Digestion / Q000187:drug effects*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000187:drug effects; D012016:Reference Values; D013270:Stomach / Q000000981:diagnostic imaging; D013997:Time Factors; D014463:Ultrasonography
D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D009853:Omeprazole