Isochromosome i(3q) and premature chromosome condensation are recurrent findings in chronic B-cell lymphocytosis with binucleated lymphocytes.
Chronic B lymphocytosis with binucleated lymphocytes (LWBL) is a recently described entity. The lymphocytosis is stable over years and atypical binucleated lymphocytes are detected on peripheral blood smears. Further investigation has shown a predominance in females, a polyclonal increase in serum IgM and HLA-DR7 expression in most cases. In almost all cases cytogenetic studies with classical culture conditions have not shown any abnormality. We describe 7 patients with LWBL associated with an abnormal karyotype. An additional i(3q) was found in 6 cases. Premature chromosome condensation (PCC) was detected in all 7 cases. As both abnormalities are rarely present in other benign or malignant proliferations, we suggest a strong correlation between LWBL and i(3q) and/or PCC.
Mossafa
H
H
Déparment de Génétique Humaine, Laboratoire Cerba, Cergy-Pontoise, France.
Troussard
X
X
Valensi
F
F
Schillinger
F
F
Maynadie
M
M
Bulliard
G
G
Macintyre
E
E
Flandrin
G
G
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology*; D001483:Base Sequence; D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002875:Chromosomes / Q000648:ultrastructure; D002893:Chromosomes, Human, Pair 3; D002908:Chronic Disease; D002999:Clone Cells; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008218:Lymphocytosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
D017931:DNA Primers