title: Pharmacologic profile of iobitridol, a nonionic iodinated contrast medium.
abstract: The present article combines and summarizes the preclinic studies carried out in vitro and in vivo to determine the pharmacologic and biochemical profile of iobitridol, a new nonionic iodinated low-osmolality contrast medium (CM). The effects of this product on the main hemodynamic, bronchopulmonary, neurologic, renal, blood chemistry and electrophysiologic parameters and RBC morphology were studied in detail in comparison with CM in the same chemical category or with reference substances of the same osmolality. The in vivo studies were performed under conditions resembling clinical use. Iobitridol showed an excellent pharmacologic and biochemical profile, which was identical or superior to that of other products in its category.
authors.affiliation: Research and Development Division, Laboratoire Guerbet, Aulnay-sous-Bois, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Idee
authors.forename: C
authors.initials: C
authors.lastname: Bault
authors.forename: H
authors.initials: H
authors.lastname: Beaufils
authors.forename: C
authors.initials: C
authors.lastname: Berthommier
authors.forename: J
authors.initials: J
authors.lastname: Cambar
authors.forename: C
authors.initials: C
authors.lastname: Corot
authors.forename: D
authors.initials: D
authors.lastname: Doucet
authors.forename: C
authors.initials: C
authors.lastname: Hartl
authors.forename: M C
authors.initials: MC
authors.lastname: Jaudon
authors.forename: C
authors.initials: C
authors.lastname: Jacquiaud
authors.forename: B
authors.initials: B
authors.lastname: Lakhdar
authors.forename: M
authors.initials: M
authors.lastname: Potier
authors.forename: R
authors.initials: R
authors.lastname: santus
authors.forename: S
authors.initials: S
authors.lastname: Torcherie
authors.forename: E
authors.initials: E
authors.lastname: Vaudon
authors.forename: B
authors.initials: B
authors.lastname: Bonnemain
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007472:Iohexol / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D003287:Contrast Media; C093233:iobitridol; D007472:Iohexol