Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection.
This case report describes infantile nephrotic syndrome (NS) in a baby girl with a clinically severe cytomegalovirus (CMV) infection. Culture of the baby's urine was positive for CMV and IgM anti-CMV antibodies were detected. After an unsuccessful course of corticosteroids, gancyclovir treatment was started and a remission of cutaneous, pulmonary, and renal symptoms was achieved. As the mother also developed NS at the end of pregnancy, a common etiology could be postulated, although there were no signs of recent CMV infection in the mother, only anti-CMV IgG. The relationship between CMV infection and glomerular disease is still unclear; NS may represent another manifestation of CMV disease.
Giani
M
M
Department of Pediatrics II, University of Milan, Italy.
Edefonti
A
A
Damiani
B
B
Marra
G
G
Colombo
D
D
Banfi
G
G
Rivolta
E
E
Strøm
E H
EH
Mihatsch
M
M
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007075:Immunoglobulin M / Q000652:urine; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D011247:Pregnancy
D000305:Adrenal Cortex Hormones; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M