Violence and schizophrenia: clozapine as a specific antiaggressive agent.
Pharmacological management of persistent aggression in patients with schizophrenia is a difficult clinical dilemma. Clozapine has been shown to be an effective agent in this regard. This study sought to compare the symptomatic response on the Brief Psychiatric Rating Scale (BPRS) between hostile schizophrenic patients and patients without aggression. While dramatic improvements were evident in aggression, both groups were indistinguishable with respect to BPRS response. These results suggest that clozapine may have a selective antiaggressive effect.
Buckley
P
P
Northcoast Behavioral Healthcare System, Northfield, OH 44167, USA.
Bartell
J
J
Donenwirth
K
K
Lee
S
S
Torigoe
F
F
Schulz
S C
SC
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006791:Hostility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D014754:Violence / Q000517:prevention & control* / Q000523:psychology
D014150:Antipsychotic Agents; D003024:Clozapine