title: "Sunbath polyneuritis": subacute axonal neuropathy in perazine-treated patients after intense sun exposure.
abstract: This article aims at drawing attention to the peculiar association of intense exposure to sunlight and subacute development of sensory neuropathy which was seen in 7 psychiatric patients treated with the phenothiazine derivative, perazine. Three patients additionally developed bilateral VII nerve palsy. Symptoms followed a monophasic course with almost complete remission. Routine neurophysiology suggested axonal neuropathy confirmed by sural nerve biopsy in 1 patient. A toxic origin of neuropathy is supposed, possibly induced by phenothiazine photoproducts, which may cause cell damage via lipid peroxidation.
authors.affiliation: University Department of Neurology, Heidelberg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Roelcke
authors.forename: C
authors.initials: C
authors.lastname: Hornstein
authors.forename: E
authors.initials: E
authors.lastname: Hund
authors.forename: H P
authors.initials: HP
authors.lastname: Schmitt
authors.forename: R
authors.initials: R
authors.lastname: Siess
authors.forename: M
authors.initials: M
authors.lastname: Kaltenmaier
authors.forename: J
authors.initials: J
authors.lastname: Fassler
authors.forename: H M
authors.initials: HM
authors.lastname: Meinck
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005158:Facial Paralysis / Q000139:chemically induced / Q000209:etiology; D005260:Female; D006370:Heliotherapy; D006801:Humans; D008297:Male; D009431:Neural Conduction; D009443:Neuritis / Q000139:chemically induced* / Q000209:etiology* / Q000473:pathology; D010464:Perazine / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries; D012559:Schizophrenia / Q000188:drug therapy; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology
chemical_list: D010464:Perazine