title: Preoperative intrahepatic segmental cholangitis in patients with advanced carcinoma involving the hepatic hilus.
abstract: BACKGROUND
  Major hepatic resection for biliary tract carcinoma continues to be a risky operation. In this study we examined the influence of preoperative intrahepatic segmental cholangitis on posthepatectomy mortality.
  
  
  METHODS
  We analyzed retrospectively the clinical features of 118 patients who underwent liver resection including more than two segments for biliary tract carcinoma involving the hepatic hilus.
  
  
  RESULTS
  Intrahepatic segmental cholangitis was encountered before operation in 22 cases. The morbidity and mortality rates for these patients were significantly higher than those of patients without preoperative cholangitis. Selective percutaneous transhepatic biliary drainage was performed before operation in 11 patients for segmental cholangitis. The morbidity rate of patients after hepatectomy was significantly lower than that of patients treated without percutaneous transhepatic biliary drainage.
  
  
  CONCLUSIONS
  The presence of preoperative intrahepatic segmental cholangitis is a major prognostic factor in the outcome of major hepatic resection for biliary carcinoma. Selective percutaneous transhepatic biliary drainage for preoperative intrahepatic segmental cholangitis plays an important role in reducing complications after major hepatic resection.
authors.affiliation: First Department of Surgery, Nagoya University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kanai
authors.forename: Y
authors.initials: Y
authors.lastname: Nimura
authors.forename: J
authors.initials: J
authors.lastname: Kamiya
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Nagino
authors.forename: M
authors.initials: M
authors.lastname: Miyachi
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000328:Adult; D000368:Aged; D001653:Bile Ducts, Intrahepatic / Q000601:surgery; D002277:Carcinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D002758:Cholangiography; D002761:Cholangitis / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D004322:Drainage; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011300:Preoperative Care; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed