Felbamate-associated fatal acute hepatic necrosis.
Thirty-six cases of hepatic toxicity associated with felbamate therapy have been collected by the Food and Drug Administration. Five patients died. We describe a case of massive acute hepatic necrosis and death within 40 days of initiation of felbamate therapy for a generalized tonic-clonic seizure disorder. We describe the clinical and histopathologic features.
O'Neil
M G
MG
Department of Pharmacy Practice, College of Medicine, Medical University of South Carolina, Charleston, USA.
Perdun
C S
CS
Wilson
M B
MB
McGown
S T
ST
Patel
S
S
D000927:Anticonvulsants / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D017809:Fatal Outcome; D000078328:Felbamate; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008875:Middle Aged; D009336:Necrosis; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000009:adverse effects*; D014481:United States; D014486:United States Food and Drug Administration
D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate