Solid state NMR and extraction studies on "phenyl"-bonded stationary phases used for solid phase extraction.
The solid phase extraction (SPE) and elution of [14C]-propranolol from aqueous buffer has been studied for a range of phenyl-bonded SPE materials. Differences were noted in the recovery of the analyte using methanol-water eluents depending upon the manufacturer and whether or not phase had been endcapped. Efficient recoveries of [14C]-propranolol were only achieved when triethylamine was added to the eluting solvent as a competing base. Solid state cross polarisation/magic angle spinning (CP/MAS) NMR spectroscopy was used to characterise the phases further, which revealed differences in endcapping between materials as well as differences in the type and extent of cross-linking.
Brindle
R
R
Universitat Tubingen, Institute fur Organische Chemie, Germany.
Albert
K
K
Morgan
E D
ED
Martin
P
P
Wilson
I D
ID
D009682:Magnetic Resonance Spectroscopy; D011433:Propranolol / Q000032:analysis* / Q000302:isolation & purification*
D011433:Propranolol