title: Paraganglioma of the cauda equina. A case report and review of the literature.
abstract: A 59-year-old man presented with clinical evidence of a primary tumor of the cauda equina region. It was well circumscribed and was completely removed by neurosurgery. Routine staining showed that it had structural similarities to an ependymoma, but immunohistochemistry with antisera to synaptophysin, NSE, chromogranin-A and PGP 9.5 proved it to be a neuroendocrine tumor, i.e. a paraganglioma. We propose the use of endocrine markers in cases with tumors of the cauda equina to differentiate a paraganglioma from an ependymoma. Paragangliomas appear to have a better clinical outcome than ependymomas. Recurrence after surgery for a paraganglioma in the cauda equina region, especially if it is encapsulated, is rarely encountered.
authors.affiliation: Department of Pathology, University Hospital, Uppsala, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Bak
authors.forename: Y
authors.initials: Y
authors.lastname: Olsson
authors.forename: L
authors.initials: L
authors.lastname: Grimelius
authors.forename: B
authors.initials: B
authors.lastname: Spännare
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002420:Cauda Equina / Q000601:surgery; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D010235:Paraganglioma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins