title: Identification of coronary artery disease by 99mTc-MIBI myocardial perfusion single photon emission computed tomography: evaluation using Diamond's method and segmental score system.
abstract: Three hundred and eighty-one consecutive patients referred to our Nuclear Medicine Service from the Cardiology Department during a period of two years have been studied to evaluate Coronary Artery Disease (CAP) using 99mTc-MIBI single photon emission computed tomography (SPECT). The sensitivity and specificity for detecting CAD in the whole group of patients, referred (n = 161) or not (n = 220) for coronary angiography, were calculated following Diamond's method, and were found to be 87% and 92%, respectively. Diamond's method estimates these values from those obtained in the subset of patients with angiography referral (sensitivity 91% and specificity 85%) and the pattern of SPECT responses of both groups (69% and 52%, respectively). A new segmental score system was used to evaluate the location and extent of CAD in the catheterized group. The sensitivity for detecting individual artery disease was 69% and specificity was 81%. The sensitivity in patients with single, double and triple-vessel disease was 90%, 96% and 89%, respectively. In the subgroup of patients without infarction (n = 66) the sensitivity and specificity were 76% (19/25) and 90% (37/41).
authors.affiliation: Nuclear Medicine and Cardiology Department, Hospital Clínic i Provincial, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Solá
authors.forename: M
authors.initials: M
authors.lastname: Moragas
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: J
authors.initials: J
authors.lastname: Magriñá
authors.forename: P
authors.initials: P
authors.lastname: Bassa
authors.forename: M
authors.initials: M
authors.lastname: Huguet
authors.forename: R
authors.initials: R
authors.lastname: Herranz
authors.forename: J
authors.initials: J
authors.lastname: Setoain
mesh_terms: D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D017256:Technetium Tc 99m Sestamibi