title: Use of porous polyurethanes for meniscal reconstruction and meniscal prostheses.
abstract: In the past, porous materials made of an aromatic polyurethane (PU) were successfully used to meniscal reconstruction in dogs. Since aromatic PUs yield very toxic fragments upon degradation, a linear PU was synthesized by curing a poly(epsilon-caprolactone) and 1,4-trans-cyclohexane diisocyanate based prepolymer with cyclohexanedimethanol. Porous materials of this polymer were also implanted for meniscal reconstruction. The results were comparable with the most successful implant series so far. Additionally, a porous meniscal prosthesis was developed to replace a total meniscus. Due to the very high shear stresses to which the prosthesis would be exposed, the stress hysteresis phenomenon linear PUs are known to exhibit could be of great consequence. Therefore an aliphatic PU network, synthesized by cross-linking poly(epsilon-caprolactone) and 1,4-trans-cyclohexane diisocyanate with glycerol, was used. Dislocation caused by tearing out of the sutures was found to be a problem because the tear resistance of the material was relatively low. In this study the tearing problem has been partly circumvented by using a complex suturing technique. Meniscal prostheses turned out to induce fibrocartilage upon implantation, and degeneration of articular cartilage was less severe than after meniscectomy.
authors.affiliation: Department of Polymer Chemistry, University of Groningen, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: de Groot
authors.forename: R
authors.initials: R
authors.lastname: de Vrijer
authors.forename: A J
authors.initials: AJ
authors.lastname: Pennings
authors.forename: J
authors.initials: J
authors.lastname: Klompmaker
authors.forename: R P
authors.initials: RP
authors.lastname: Veth
authors.forename: H W
authors.initials: HW
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001555:Benzene Derivatives; D001672:Biocompatible Materials / Q000592:standards; D001696:Biomechanical Phenomena; D002152:Calorimetry, Differential Scanning; D003432:Cross-Linking Reagents; D003485:Cyanates / Q000737:chemistry; D004285:Dogs; D005612:Freeze Drying; D006801:Humans; D007720:Knee Prosthesis / Q000592:standards*; D008592:Menisci, Tibial / Q000601:surgery* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry / Q000592:standards*; D016062:Porosity
chemical_list: D001555:Benzene Derivatives; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003485:Cyanates; D011091:Polyesters; D011140:Polyurethanes; C016240:polycaprolactone; C036662:cyclohexane diisocyanate