Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent.
The therapeutic efficacy of short-term treatment with a 1% cream of lanoconazole, a new imidazole antimycotic agent, in comparison with that of a 1% cream of terbinafine was evaluated in the guinea pig model of tinea pedis. Each agent was topically applied once a day for 3 or 7 consecutive days, starting on day 10 postinfection, and a culture study was conducted on day 5 after the last treatment with each agent. The 1% cream of lanoconazole was as highly effective as the 1% cream of terbinafine in terms of eradicating the fungi from the infected feet.
Niwano
Y
Y
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd., Osaka, Japan.
Tabuchi
T
T
Kanai
K
K
Hamaguchi
H
H
Uchida
K
K
Yamaguchi
H
H
D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D014008:Tinea Pedis / Q000188:drug therapy* / Q000473:pathology
D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D007093:Imidazoles; C072774:latoconazole