Multiple periorbital cutaneous myxomas progressing to scleromyxedema.
Myxomas are rare cutaneous tumors that have been associated with a variety of other abnormalities including atrial myxomas, endocrine abnormalities, and bone malformations. We describe a 38-year-old white man with multiple periorbital myxomas in whom myalgias, fatigue, and more diffuse cutaneous involvement developed. These findings were consistent with scleromyxedema. He also had an associated left subclavian deep venous thrombosis. The patient responded well to therapy with cyclophosphamide.
Craig
N M
NM
Department of Dermatology, Northwestern University Medical School, Chicago, IL 60611, USA.
Putterman
A M
AM
Roenigk
R K
RK
Wang
T D
TD
Roenigk
H H
HH
D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005153:Facial Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005221:Fatigue / Q000209:etiology; D006801:Humans; D008297:Male; D009230:Myxedema / Q000209:etiology*; D009232:Myxoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009915:Orbit; D012594:Scleroderma, Localized / Q000209:etiology; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013924:Thrombophlebitis / Q000209:etiology
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide