Magnetic resonance imaging in vivo monitoring of T2 relaxation time: quantitative assessment of primate brain maturation.
This work describes quantitative MRI assessment of primate brain maturation. Nine young baboons were followed from the age of one to 30 months. Assessment of myelination was based on the gray/white matter contrast on MR images and the evolution of T2 relaxation time respectively. The brain maturation began in the posterior fossa and progressed to the olfactory bulbs corresponding to decreasing white matter T2 values. Relaxation parameters provide new opportunities to trace the myelination process in vivo.
Miot
E
E
Laboratoire de Biophysique Cellulaire et RMN, INSERM U316-CNRS, Tours, France.
Hoffschir
D
D
Poncy
J L
JL
Masse
R
R
Le Pape
A
A
Akoka
S
S
D000375:Aging; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009186:Myelin Sheath / Q000502:physiology; D009830:Olfactory Bulb / Q000033:anatomy & histology; D009928:Organ Specificity; D010215:Papio / Q000254:growth & development*