Takayasu's arteritis associated with antiphospholipid antibodies. Report of two cases.
The authors describe 2 patients with Takayasu's arteritis in whom lupus anticoagulant was positive and the titer of anticardiolipin antibody was elevated. One patient developed diffusely stenotic and occlusive changes in the multiple larger arteries. Histology of the small-sized arteries in another patient showed occlusive vasculitis without thrombosis, in addition to the findings in large-sized arteries compatible with Takayasu's disease. These findings are uncommon in Takayasu's arteritis. These findings suggest that antiphospholipid antibodies may have contributed to the pathogenesis of the extensive vasculopathy and may have triggered vasculitis in these patients.
Yokoi
K
K
Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan.
Hosoi
E
E
Akaike
M
M
Shigekiyo
T
T
Saito
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D001157:Arterial Occlusive Diseases / Q000276:immunology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D013625:Takayasu Arteritis / Q000276:immunology* / Q000473:pathology; D014657:Vasculitis / Q000276:immunology / Q000473:pathology
D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor