title: K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities.
abstract: Capsular polysaccharide antigens isolated from Klebsiella pneumoniae sero-type 1 (K1) and sero-type 3 (K3) could induce tumor necrosis factor-alpha in ICR mice. K1 and K3 capsular antigens were found to be non-toxic by brine shrimp bioassay. When injected into Ehrlich ascites tumor-bearing mice, both K1 and K3 capsular antigens exhibited significant suppression in the growth of tumor cells. The significance of these observations is discussed.
authors.affiliation: Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Y M
authors.initials: YM
authors.lastname: Choy
authors.forename: S F
authors.initials: SF
authors.lastname: Tsang
authors.forename: S K
authors.initials: SK
authors.lastname: Kong
authors.forename: K N
authors.initials: KN
authors.lastname: Leung
authors.forename: H
authors.initials: H
authors.lastname: Parolis
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
authors.forename: K P
authors.initials: KP
authors.lastname: Fung
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000494:pharmacology*; D001156:Artemia; D016667:Bacterial Capsules; D001599:Berberine / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division / Q000187:drug effects; D006626:Hippurates / Q000633:toxicity; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D000942:Antigens, Bacterial; D006626:Hippurates; D011135:Polysaccharides, Bacterial; D014409:Tumor Necrosis Factor-alpha; C036962:capsular polysaccharide K1; C098418:capsular polysaccharide K3; D001599:Berberine; C030514:hippuric acid