Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype.
Some neuropathological changes characteristic of aging and Alzheimer's disease (AD) in humans are present also in senescent non-human primates. The human apoE4 allele is associated with an increased risk of developing late-onset familial and sporadic AD. We found that rhesus monkeys and three subspecies of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158 as in human apoE4. However, in both species threonine replaces arginine at position 61 of human apoE. It was previously shown that arginine 61 was critical in determining apoE4 lipoprotein distribution in humans.
Morelli
L
L
Department of Pharmacology, New York University Medical Center, NY 10016, USA.
Wei
L
L
Amorim
A
A
McDermid
J
J
Abee
C R
CR
Frangione
B
B
Walker
L C
LC
Levy
E
E
D000544:Alzheimer Disease / Q000235:genetics; D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000235:genetics*; D000818:Animals; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D002561:Cerebrovascular Disorders / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005838:Genotype; D006801:Humans; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012453:Saimiri; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015252:Deoxyribonucleases, Type II Site-Specific; C037130:GCGC-specific type II deoxyribonucleases