Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888.
Xanthoquinodin B3, a new component of anticoccidial xanthoquinodins, which was detected in the culture broth of Humicola sp. FO-888, was isolated by heat treatment of the xanthoquinodins complex. Structural elucidation indicated that xanthoquinodin B3 has the same heterodimer of xanthone- and anthraquinone-derived monomers as other xanthoquinodins. Schizont formation of monensin-resistant Eimeria tenella in BHK-21 cells was inhibited by xanthoquinodin B3 at concentrations greater than 0.035 microM.
Tabata
N
N
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Tomoda
H
H
Iwai
Y
Y
Omura
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002867:Chromones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D003049:Coccidiostats / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D006224:Cricetinae; D016786:Eimeria tenella / Q000187:drug effects / Q000254:growth & development; D006358:Hot Temperature; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000378:metabolism*; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D002867:Chromones; D003049:Coccidiostats; C099307:xanthoquinodin B3