Lack of inhibitory effects of beta-carotene, vitamin C, vitamin E and selenium on development of ductular adenocarcinomas in exocrine pancreas of hamsters.
The effects of vitamins E and E, beta-carotene and selenium on development of N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic tumours in hamsters were investigated. Dietary supplementation of vitamin C, alone as well as in combination with beta-carotene resulted in consistently lower numbers of advanced ductular lesions. The differences with the controls, however, did not reach the level of statistical significance. Beta-Carotene alone demonstrated no inhibitory effect on the development of (pre)neoplastic lesions in the pancreas. Vitamin E or Se, either alone or in combination, had no effect on the development of advanced ductular lesions in BOP-treated hamsters.
Appel
M J
MJ
Department of Pathology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
van Garderen-Hoetmer
A
A
Woutersen
R A
RA
D000230:Adenocarcinoma / Q000209:etiology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D018270:Carcinoma, Ductal, Breast / Q000209:etiology*; D002338:Carotenoids / Q000494:pharmacology*; D006224:Cricetinae; D004032:Diet; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines; D009929:Organ Size / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000209:etiology*; D012643:Selenium / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D019207:beta Carotene
D002273:Carcinogens; D009602:Nitrosamines; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; C013622:nitrosobis(2-oxopropyl)amine; D012643:Selenium; D001205:Ascorbic Acid