Synthesis and post-coital contraceptive activity of ether and ester analogues of 2,3-diaryl-2H-1-benzopyrans.
Ether and ester analogues of 2,3-diaryl-2H-1-benzopyrans have been synthesised and tested for their pregnancy inhibiting activity in immature rats. Some of the compounds exhibit potent activity. Structure-activity relationship relative to the hydroxy analogue has been discussed. In general, esters were found to be better inhibitory agents.
Hajela
K
K
Regional Research Laboratory, Jammu Tawi, India.
Kapoor
K K
KK
Kapil
R S
RS
D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D003283:Contraceptives, Postcoital, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D013329:Structure-Activity Relationship
D001578:Benzopyrans; D003283:Contraceptives, Postcoital, Synthetic