title: The uptake mechanisms of inflammation- and infection-localizing agents.
abstract: Over the past 30 years, a wide variety of radiopharmaceuticals have been proposed for the scintigraphic detection of inflammatory and infectious disease. All radiopharmaceuticals yield a functional image of a process placed somewhere in the cascade of reactions in inflammation, this being the common pathway of response to tissue injury. This paper discusses relevant aspects of the biodistribution, in vivo kinetics and mechanisms of uptake of both clinically used and experimental radiopharmaceuticals that have been proposed for the scintigraphic detection of focal inflammation and infection.
authors.affiliation: Department of Nuclear Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Oyen
authors.forename: O C
authors.initials: OC
authors.lastname: Boerman
authors.forename: C J
authors.initials: CJ
authors.lastname: van der Laken
authors.forename: R A
authors.initials: RA
authors.lastname: Claessens
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
authors.forename: F H
authors.initials: FH
authors.lastname: Corstens
mesh_terms: D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging* / Q000378:metabolism; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000378:metabolism; D007962:Leukocytes / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
chemical_list: D005710:Gallium Radioisotopes