title: Cortical projections to spinal motoneurons: changes with aging and amyotrophic lateral sclerosis.
abstract: Peristimulus time histograms (PSTHs) of discharging single motor units, recorded from the extensor digitorum communis (EDC) during randomly applied cortical magnetic stimulation, were obtained in 42 normal subjects aged 24 to 83 years and 42 patients with amyotrophic lateral sclerosis (ALS) aged 37 to 84 years. Normal subjects had an early period of increased firing probability occurring at about 20 msec poststimulus, reflecting an underlying compound excitatory postsynaptic potential (EPSP) induced by fast-conducting, descending volleys of the corticomotoneuronal core facilitating the single spinal motoneuron. There was an age-dependent, linear decline in the amplitude of the EPSP (r = 0.673). We estimated that by age 50 years about 35% of corticomotoneurons are lost or nonfunctioning in normal controls. Compared with age-matched controls, the EPSP in most patients with ALS was reduced, and it was unmeasurable in six. We postulate this reflects a loss of corticomotoneurons. Seven (16.7%) patients phenotypically the same as the others had EPSPs that were larger than age-predicted values. This may reflect glutamate-induced excitotoxicity in a subset of ALS. In a single patient with chronic spinal muscular atrophy the EPSP was normal.
authors.affiliation: Neuromuscular Diseases Unit, Vancouver General Hospital, BC, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Eisen
authors.forename: M
authors.initials: M
authors.lastname: Entezari-Taher
authors.forename: H
authors.initials: H
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D012016:Reference Values; D012044:Regression Analysis; D013116:Spinal Cord / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D009435:Synaptic Transmission; D013997:Time Factors