Ifosfamide nephrotoxicity in children: histopathological features in two cases.
We report on two children with rhabdomyosarcoma who received ifosfamide as part of their chemotherapy schedule. Both children subsequently developed severe ifosfamide-induced nephrotoxicity, necessitating electrolyte supplementation. We describe the histopathological findings of renal biopsies performed in these children after the onset of renal dysfunction and comment on the possible mechanisms involved in ifosfamide nephrotoxicity.
Morland
B J
BJ
Department of Oncology, Children's Hospital, Birmingham, UK.
Mann
J R
JR
Milford
D V
DV
Raafat
F
F
Stevens
M C
MC
D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012208:Rhabdomyosarcoma / Q000188:drug therapy
D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide