Alpha adrenoceptor gene expression in the rat iris during development and maturity.
We have examined the developmental profile of the alpha-1 and alpha-2 adrenergic receptor mRNA expression in the rat iris. The expression of the six mRNAs was studied using reverse transcription-polymerase chain reaction. At 4 weeks, the dominant mRNA transcripts in the rat iris were alpha-1B, alpha-1C and alpha-2A. This pattern of alpha adrenoceptor expression was seen from birth, throughout development, and maintained into old age.
Vidovic
M
M
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Hill
C E
CE
D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007498:Iris / Q000254:growth & development / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
D012333:RNA, Messenger; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2