title: Prediction of recurrence in B-C stages of colorectal cancer by p53 nuclear overexpression in comparison with standard pathological features.
abstract: This study investigated the predictive value of p53 nuclear overexpression on recurrence of colorectal adenocarcinomas compared with established prognostic pathological features. Sixty-one paraffin-embedded sections from primary tumours were examined by immunohistochemistry. Specific nuclear staining was detected in 27 (44.2%) cases. Positivity was more frequent in tumours with venous invasion (76.9%) (P = 0.06) and in rectal cancer (68.4%) (P = 0.06). After a median observation time of 46 months, p53-positive tumours exhibited a higher percentage of recurrence (40.7% vs 11.7%) (P = 0.03), and a higher likelihood of relapse at 5-year follow-up (46% vs 13%) (P = 0.006). Among the pathological variables analysed, only the extent of bowel wall invasion showed a relationship with recurrence. After adjustment for the other covariates in a Cox's regression model, p53 overexpression was the only factor showing independent prognostic significance (hazard ratio: 4.96; 95% Confidence Interval (CI): 1.47-16.71) (P = 0.012). The results of this study show that nuclear p53 protein overexpression has higher predictive value than standard pathological variables.
authors.affiliation: Hospital Príncipe de Asturias, University of Alcalá de Henares, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Diez
authors.forename: J M
authors.initials: JM
authors.lastname: Enriquez
authors.forename: J
authors.initials: J
authors.lastname: Camuñas
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez
authors.forename: A
authors.initials: A
authors.lastname: Gutierrez
authors.forename: J M
authors.initials: JM
authors.lastname: Mugüerza
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: J
authors.initials: J
authors.lastname: Granell
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007422:Intestines / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000235:genetics; D011237:Predictive Value of Tests; D011336:Probability; D011379:Prognosis