Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.
In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.
Matsumoto
M
M
Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mariathasan
S
S
Nahm
M H
MH
Baranyay
F
F
Peschon
J J
JJ
Chaplin
D D
DD
D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D018390:Gene Targeting; D018858:Germinal Center / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D007114:Immunization; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000502:physiology*; D013154:Spleen / Q000033:anatomy & histology / Q000276:immunology*
D008233:Lymphotoxin-alpha; D018124:Receptors, Tumor Necrosis Factor