Donor leucocyte transfusions for relapse in myelodyplastic syndrome after allogeneic bone marrow transplantation.
A 31-year-old man with refractory anaemia of excess blasts, which had karyotypic abnormalities, received an allogeneic bone marrow transplant (BMT). At time of relapse, 3 months after BMT, he was treated with donor leucocyte transfusion (DLT). Grade III acute GVHD (graft-versus-host disease) occurred 35 d after DLT which was fully reversed with cyclosporin and prednisolone. His condition was complicated by a herpes zoster infection. 2 months after DLT, neutrophil and platelet count were increased and karyotypic abnormalities disappeared. This observation demonstrates that DLT is an effective treatment for relapse of myelodysplastic syndrome (MDS) after BMT.
Okumura
H
H
Department of Internal Medicine, Toyama Prefectural Central Hospital, Japan.
Takamatsu
H
H
Yoshida
T
T
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D016572:Cyclosporine / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D017708:Leukocyte Transfusion; D008297:Male; D009190:Myelodysplastic Syndromes / Q000628:therapy*; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D014182:Transplantation, Autologous
D016572:Cyclosporine; D011239:Prednisolone