Autoantibody against a 58 kD molecule in a patient with neutropenia and NK cell deficiency.
A patient with Evans' syndrome is described who developed intermittently an immunocytopenia consisting of autoimmune neutropenia and natural killer (NK) cell deficiency. During this time an autoantibody binding to a 58 kD antigen expressed on granulocytes, activated NK cells and Epstein-Barr virus (EBV) transformed B cells was present. Incubation of activated NK cells and NK cell clones with the autoantibody leads to a significant inhibition of NK activity. Therefore the autoantibody may detect a functionally important activation molecule.
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Abteilung fur Klinische Immunologie, Medizinische Hochschule Hannover, Germany.
Bode
F M
FM
Hammer
M
M
Deicher
H
H
Schmidt
R E
RE
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D015153:Blotting, Western; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008970:Molecular Weight; D009503:Neutropenia / Q000276:immunology*; D013577:Syndrome; D013921:Thrombocytopenia / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G