title: Antibiotics A21459 A and B, new inhibitors of bacterial protein synthesis. I. Taxonomy, isolation and characterization.
abstract: Novel cyclic peptide antibiotics A21459 A and B are produced by a member of the genus Actinoplanes sp. These antibiotics inhibit bacterial protein synthesis and have selective antimicrobial activity against clostridia, mycoplasma and some Gram-negative bacteria.
authors.affiliation: Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (VA), Italy.
authors.forename: E
authors.initials: E
authors.lastname: Selva
authors.forename: L
authors.initials: L
authors.lastname: Gastaldo
authors.forename: G S
authors.initials: GS
authors.lastname: Saddler
authors.forename: G
authors.initials: G
authors.lastname: Toppo
authors.forename: P
authors.initials: P
authors.lastname: Ferrari
authors.forename: G
authors.initials: G
authors.lastname: Carniti
authors.forename: B P
authors.initials: BP
authors.lastname: Goldstein
mesh_terms: D000191:Actinomycetaceae / Q000145:classification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology
chemical_list: C099219:A21459 A; C099220:A21459 B; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010456:Peptides, Cyclic