title: Modeling interstitial flow in an artery wall allows estimation of wall shear stress on smooth muscle cells.
abstract: The arterial media is modeled as a periodic array of cylindrical smooth muscle cells residing in a matrix comprised of proteoglycan and collagen fibers. Using Brinkman's model to describe transmural flow through such a fibrous media, we calculate the effective hydraulic permeability of the media and the wall shear stress on smooth muscle cells. Two interesting results are obtained: first, the wall shear stress on smooth muscle cells is on the order of 1 dyne/cm2, which is the range known to affect endothelial cells in vitro; second, the flow resistance due to smooth muscle cells is not negligible compared to the resistance due to the fiber matrix.
authors.affiliation: Department of Chemical Engineering, Pennsylvania State University, University Park 16802, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Tarbell
mesh_terms: D001158:Arteries / Q000502:physiology*; D001696:Biomechanical Phenomena; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000502:physiology*; D012039:Regional Blood Flow; D013314:Stress, Mechanical