Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil.
Two cases of acute leukaemia have developed in a group of 77 patients treated with chlorambucil (Chl) because of severe juvenile chronic arthritis. The total follow-up from the beginning of Chl treatment in these patients was 560 years, indicating a highly increased risk of leukaemia. Despite favourable results, especially in patients with secondary amyloidosis, Chl should only be used in selected cases.
Kauppi
M J
MJ
Rheumatism Foundation Hospital, Heinola, Finland.
Savolainen
H A
HA
Anttila
V J
VJ
Isomäki
H A
HA
D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002675:Child, Preschool; D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced*; D008297:Male
D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil