Translocation (Y;1)(q12;q12) in hematologic malignancies. Report on two new cases, FISH characterization, and review of the literature.
Translocation (Y;1)(q12;q12) is a rare cytogenetic anomaly occurring in hematologic disorders thought to affect stem cells. We report here on two new cases, one end-stage myelofibrosis and one chronic myelomonocytic leukemia. The translocation breakpoints were assessed by conventional cytogenetic techniques in both cases and by FISH in the second case. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.
Michaux
L
L
Center for Human Genetics, University of Louvain, Belgium.
Wlodarska
I
I
Vellosa
E R
ER
Verhoef
G
G
Van Orshoven
A
A
Michaux
J L
JL
Scheiff
J M
JM
Mecucci
C
C
Van den Berghe
H
H
D000293:Adolescent; D000368:Aged; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D055728:Primary Myelofibrosis / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy; D014998:Y Chromosome