Mechanisms of eukaryotic transcription: surfaces, complexes, and contexts. (Cold Spring Harbor Cancer Cells Meeting, August 30-September 3, 1995).
As with other biological processes, evolution has resulted in numerous, alternative pathways to achieve regulation of gene expression. In the elaborate series of steps required to transcribe a gene, necessitating assembly and subsequent disassembly of multiple complexes, subtle alterations in specific protein-protein interactions can lead to dramatically different transcriptional consequences.
Hansen
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Division of Molecular Genetics, Dana-Farber Cancer Institute, Boston, USA.
D000818:Animals; D005057:Eukaryotic Cells / Q000502:physiology; D006801:Humans; D014158:Transcription, Genetic / Q000502:physiology*