title: The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene.
abstract: The gene encoding the proteinase 3. (PRTN3, myeloblastin) was localized to chromosomal band 19p13.3 by radioactive and fluorescent in situ hybridization (FISH) to normal metaphase chromosomes. This localization was shown to be telomeric to the E2A gene by performing FISH to metaphases with balanced translocation t(1;19)((q23;p13) characteristic for a pre-B subtype of acute leukemia. In the unbalanced form of this translocation, a monoallelic loss of the PRTN3 locus was observed with FISH.
authors.affiliation: Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Le Coniat
authors.forename: R
authors.initials: R
authors.lastname: Berger
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D012697:Serine Endopeptidases; D053146:Myeloblastin