[Alpha-fetoprotein suppresses keratinocyte proliferation in vitro].
The influence of alpha-fetoprotein (AFP) on the proliferation of human epidermal keratinocytes in vitro has been studied. AFP (1p microgram/ ml) inhibits the proliferation of keratinocytes cultivated in a serum-free medium. The addition of fetal bovine serum significantly enhances the effect of AFP in this culture. A similar effect of AFP is observed in a medium with a low content of calcium ions.
Voroteliak
E A
EA
Vasil'ev
A V
AV
Gusev
S A
SA
Povaliĭ
T M
TM
Terskikh
V V
VV
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D003864:Depression, Chemical; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects*; D000509:alpha-Fetoproteins / Q000494:pharmacology*
D003470:Culture Media; D000509:alpha-Fetoproteins