title: Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency.
abstract: Factor XI (F XI) deficiency is an autosomal recessive coagulopathy found in Holstein cattle. Affected animals have a 50% greater prevalence of repeat breeding. Therefore, several parameters describing ovarian function were studied. Daily blood sampling revealed that progesterone concentrations were slower to decline from a peak at day 16 (p < 0.01) to values less than 3 nmol/L in F XI-deficient cows (5.14 +/- 0.69 days (mean +/- SD) versus 4.05 +/- 0.63 days in control animals), resulting in an oestrous cycle length of 24.7 +/- 2.1 days compared to 22.9 +/- 3.0 days, respectively. This was not due to an alteration in the availability of prostaglandin F2 alpha (PGF2 alpha) or oxytocin (OT) involved in luteolysis. No significant differences (p > 0.05) were seen between normal (n = 7) and F XI-deficient (n = 7) cows in the peak values or the area under the curve for the pulse in 13,14-dihydro-15-keto PGF2 alpha in response to OT challenge or in the parameters describing the pulse of ovarian OT secretion after PGF2 alpha injection (n = 7 for each) between days 12 and 14. Ovulatory follicular development was assessed by ultrasound monitoring and plasma 17 beta-oestradiol values at 8-h intervals after a luteolytic injection of cloprostenol (n = 6 for each). Follicular diameter was smaller (p < 0.05) and accompanied by lower peak oestradiol values near the time of ovulation in F XI-deficient cows. The results suggest that the oestrous cycle in F XI-deficient cows is characterized by a slower process of luteolysis that may be associated with smaller follicular development.
authors.affiliation: Department of Biomedical Sciences, University of Guelph, Ontario, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Liptrap
authors.forename: P A
authors.initials: PA
authors.lastname: Gentry
authors.forename: M L
authors.initials: ML
authors.lastname: Ross
authors.forename: E
authors.initials: E
authors.lastname: Cummings
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D004958:Estradiol / Q000097:blood; D004971:Estrus / Q000378:metabolism / Q000502:physiology; D005172:Factor XI / Q000235:genetics / Q000378:metabolism; D005173:Factor XI Deficiency / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D005808:Genes, Recessive; D006720:Homozygote; D006080:Ovarian Follicle / Q000378:metabolism / Q000503:physiopathology*; D010121:Oxytocin / Q000097:blood; D011374:Progesterone / Q000097:blood
chemical_list: C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D004958:Estradiol; D010121:Oxytocin; D005172:Factor XI; D015237:Dinoprost