title: A tau promoter region without neuronal specificity.
abstract: The microtubule-associated protein tau is produced from a 6-kb mRNA expressed primarily in neurons. A 2-kb tau mRNA has also been characterized, which produces a tau isoform that localizes to the nucleus, and an 8-kb mRNA is expressed in the PNS. Mapping and sequencing of the human tau gene start showed that it has an unusually GC-rich 5'-untranslated region coded by a single untranslated exon (designated -1). Primer extensions and expression assays indicated that upstream of exon -1 is a promoter that is not neuron specific. This region contains consensus binding sites for transcription factors AP2, Sp1, and GCF.
authors.affiliation: Department of Neurology (Neuroscience), Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: A
authors.initials: A
authors.lastname: Andreadis
authors.forename: B K
authors.initials: BK
authors.lastname: Wagner
authors.forename: J A
authors.initials: JA
authors.lastname: Broderick
authors.forename: K S
authors.initials: KS
authors.lastname: Kosik
mesh_terms: D001483:Base Sequence; D003596:Cytosine / Q000502:physiology; D005091:Exons / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics*; D017930:Genes, Reporter / Q000235:genetics; D006147:Guanine / Q000502:physiology; D006367:HeLa Cells / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012680:Sensitivity and Specificity; D014158:Transcription, Genetic / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins; D006147:Guanine; D003596:Cytosine