title: Elevated serum levels of soluble ICAM-1 in non-Hodgkin's lymphomas correlate with tumour burden, disease activity and other prognostic markers.
abstract: The serum levels of soluble ICAM-1 (CD54) were significantly elevated in patients with non-Hodgkin's lymphomas (NHL, n=127) and hairy cell leukaemia (HCL, n=15) compared with healthy controls (n=31). In high-grade malignant NHL (n=79) the sICAM-1 levels correlated with the tumour mass as reflected in the Ann Arbor staging system but not with bulky disease. Further, the sICAM-1 levels correlated with disease activity as reflected by the presence of B symptoms and with other known prognostic markers. In particular serum thymidine kinase (sTK). In patients with low-grade malignant NHL (n=48) a trend towards higher serum levels of sICAM-1 was found in patients with advanced stage and B symptoms. In both low and high-grade malignant NHL, elevated levels of sICAM-1 were associated with poorer overall and disease-free survival. The present results indicated that sICAM-1 levels have a prognostic power equal to that of other serum markers claimed to be of prognostic value in NHL, namely serum lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), beta-2-microglobulin (beta2m), serum thymidine kinase (sTK), albumin and orosomucoid. The cellular origin and the possible interactions between soluble and surface ICAM-1 and its ligands needs further exploration.
authors.affiliation: Department of Haematology, University Hospital, Uppsala, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Christiansen
authors.forename: C
authors.initials: C
authors.lastname: Gidlof
authors.forename: M
authors.initials: M
authors.lastname: Kälkner K
authors.forename: H
authors.initials: H
authors.lastname: Hagberg
authors.forename: H
authors.initials: H
authors.lastname: Bennmarker
authors.forename: T
authors.initials: T
authors.lastname: Tötterman
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D018799:Intercellular Adhesion Molecule-1