DNA methylation, molecular genetic, and linkage studies in prostate cancer.
Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.
Jarrard
D F
DF
Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Bova
G S
GS
Isaacs
W B
WB
D002872:Chromosome Deletion; D004247:DNA / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008745:Methylation; D011471:Prostatic Neoplasms / Q000235:genetics*
D004247:DNA