title: Comparison of saline infusion sonography with office hysteroscopy for the evaluation of the endometrium.
abstract: OBJECTIVE
  Intrauterine infusion of saline solution during transvaginal ultrasonography enhances visualization of the endometrium. We compared the accuracy and pain rating of saline infusion sonography with those of flexible office hysteroscopy.
  
  
  METHODS
  The uterine cavities of 130 patients with abnormal bleeding were evaluated by two physicians in an office setting. Findings of endometrial polyps, submucous myomas, synechiae, endometrial hyperplasia, or cancer were recorded independently and subsequently compared. Patients rated their pain after each procedure.
  
  
  RESULTS
  Both procedures were performed in 113 of 130 patients. With saline infusion sonography pathologic findings were identified in 61 patients (54%). For all findings combined, sensitivity was 0.96 and specificity was 0.88, compared with hysteroscopy. The results of saline infusion sonography and hysteroscopy did not differ significantly (p = 0.18). The former was less painful for patients than hysteroscopy (p < 0.0001).
  
  
  CONCLUSIONS
  Saline infusion sonography is an accurate and well-tolerated method to evaluate abnormal uterine bleeding, compared with hysteroscopy.
authors.affiliation: Department of Gynecology, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: T
authors.initials: T
authors.lastname: Widrich
authors.forename: L D
authors.initials: LD
authors.lastname: Bradley
authors.forename: A R
authors.initials: AR
authors.lastname: Mitchinson
authors.forename: R L
authors.initials: RL
authors.lastname: Collins
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D015907:Hysteroscopy; D007889:Leiomyoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D008875:Middle Aged; D010146:Pain; D011127:Polyps / Q000000981:diagnostic imaging / Q000473:pathology; D017698:Postmenopause; D017697:Premenopause; D012965:Sodium Chloride; D012996:Solutions; D014463:Ultrasonography; D014591:Uterine Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D014592:Uterine Hemorrhage / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D012996:Solutions; D012965:Sodium Chloride