Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: evaluation of current treatment.
The postantibiotic effects (PAEs) OF 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The beta-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.
Walsh
A L
AL
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Smith
M D
MD
Wuthiekanun
V
V
White
N J
NJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016957:Burkholderia pseudomallei / Q000187:drug effects*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D008554:Melioidosis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents