title: Evaluation of morbidity among human T lymphotropic virus type 1 carriers in Miyazaki, Japan.
abstract: Morbidity associated with human T lymphotropic virus type I (HTLV-I) infection was investigated in a Japanese population within an area in which HTLV-I infection is endemic. Of 1824 subjects enrolled in the Miyazaki Cohort Study between November 1984 and May 1991, 500 (27.4%) were seropositive for HTLV-I antibodies. As expected from previous studies, HTLV-I positively appeared to be associated with baseline history of anemia (adjusted odds ratio [OR]= 1.3; 95% confidence interval [CI]= 0.99-1.7) and kidney disease (OR=1.6; 95% CI= 0.91-2.9); a positive association also was noted for asthma in men (OR=3.4; 95% CI=1.2-9.8). Unanticipated findings included a relationship between HTLV-I infection and cardiac disease history (OR=1.4; 95% CI=0.94-2.2; HTLV-I carriers also were more likely to have an abnormal electrocardiogram at baseline (OR=1.5; 95% CI=1.2-1.9). Furthermore, an apparent protective effect for ulcers (OR=0.62; 95% CI=0.40-0.95) and diabetes (OR=0.49;95% CI=0.22-1.1) was observed. HTLV-I infection may modify the risk of specific disease outcomes by altering host immune function.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, 02115, USA.
authors.forename: S O
authors.initials: SO
authors.lastname: Stuver
authors.forename: N
authors.initials: N
authors.lastname: Tachibana
authors.forename: A
authors.initials: A
authors.lastname: Okayama
authors.forename: N E
authors.initials: NE
authors.lastname: Mueller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications; D001249:Asthma / Q000150:complications; D002353:Carrier State / Q000453:epidemiology* / Q000276:immunology; D015331:Cohort Studies; D006800:Deltaretrovirus Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D048909:Diabetes Complications; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007674:Kidney Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D012307:Risk Factors; D014456:Ulcer / Q000150:complications
chemical_list: D015481:HTLV-I Antibodies