A primary cutaneous non-T, non-B CD4+, CD56+ lymphoma.
BACKGROUND
Cutaneous lymphomas are heterogeneous clonal lymphoproliferative disorders originating from B or T lymphocytes.


METHODS
We describe a patient with a unique primary cutaneous lymphoma characterized by a bruise-like aspect of the skin lesions, a CD4+, CD43+, CD56+, CD2-, CD3-, CD8-, T-cell receptor-negative phenotype of the medium-sized to large lymphoid tumor cells and an undetermined genotype (T-cell receptor beta and immunoglobulin heavy chain in germline configuration, no clonal T-cell receptor gamma population as detected after analysis with polymerase chain reaction combined with denaturing gradient gel electrophoresis) and fast relapse after radiotherapy.


CONCLUSIONS
This non-B, non-T cutaneous lymphoma cannot be classified by any current lymphoma classification. It seems to represent a new disease entity with peculiar clinical, histologic, and molecular features.
Dummer
R
R
Department of Dermatology, University of Zürich, Switzerland.
Potoczna
N
N
Häffner
A C
AC
Zimmermann
D R
DR
Gilardi
S
S
Burg
G
G
D000951:Antigens, Neoplasm / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis*; D019002:CD56 Antigen / Q000032:analysis*; D005145:Face; D005260:Female; D006801:Humans; D007866:Leg; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology*
D000951:Antigens, Neoplasm; D015704:CD4 Antigens; D019002:CD56 Antigen