New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation.
New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.
Esteban
A I
AI
Instituto de Química Médica (CSIC), Madrid, Spain.
Juanes
O
O
Conde
S
S
Goya
P
P
De Clercq
E
E
Martínez
A
A
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D013829:Thiadiazines / Q000138:chemical synthesis*; D014709:Vero Cells
D000998:Antiviral Agents; D013829:Thiadiazines