Amelanotic lentigo maligna melanoma: a diagnostic conundrum-- presentation of four new cases.
BACKGROUND
The clinical appearance of amelanotic lentigo maligna melanoma (ALMM) is quite confusing and usually is not diagnosed prior to histopathologic examination.


METHODS
We have studied four new patients with ALMM whose correct diagnosis was not obtained from any one clinical finding. We arrived at the final diagnosis in an unexpected way, having had biopsied the lesions for diagnoses other than malignant melanoma.


RESULTS
ALMM presents as a nonspecific skin lesion with no single indicative characteristic. A search of the literature confirmed our difficulty in making the diagnosis.


CONCLUSIONS
To diagnose ALMM, one has to be cognizant of this condition and has to consider a constellation of findings that are unusual with melanocytic lesions. Questionable lesions must be biopsied for definitive histopathologic diagnosis.
Rahbari
H
H
Department of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Nabai
H
H
Mehregan
A H
AH
Mehregan
D A
DA
Mehregan
D R
DR
Lipinski
J
J
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D018328:Melanoma, Amelanotic / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology