Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies.
In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose.
McCarver-May
D G
DG
Department of Pediatrics, Children's Hospital of Michigan, Detroit, USA.
Kang
J
J
Aouthmany
M
M
Elton
R
R
Mowery
J L
JL
Slovis
T L
TL
Kauffman
R
R
D002697:Chloral Hydrate / Q000494:pharmacology; D016292:Procedural Sedation; D018592:Cross-Over Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007231:Infant, Newborn; D008874:Midazolam / Q000494:pharmacology; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate; D008874:Midazolam