title: Clinical and pathological features of hereditary prostate cancer.
abstract: OBJECTIVE
  We determined whether the clinical and pathological features of hereditary prostate cancer differ from those of sporadic prostate cancer.
  
  
  METHODS
  We compared the clinical and pathological features of radical prostatectomy specimens from 50 men with and 50 without a family history of prostate cancer who were matched for age and date of surgery.
  
  
  RESULTS
  Median serum prostate specific antigen concentration was not significantly different in the 2 groups. Mean Gleason score plus or minus standard deviation in the 50 men with sporadic prostate cancer was 6.2 +/- 1 compared to 5.6 +/- 0.9 in those with hereditary disease (p = 0.008). Of the 50 hereditary and 50 sporadic prostate cancers 35 (70%) and 33 (66%), respectively, were pathologically organ confined (p = 0.69). Median percentage of carcinoma within the gland (determined morphometrically) in men with hereditary disease was 11.4 +/- 8.3 compared to 10.9 +/- 8.9 for those with sporadic cancer (p = 0.63).
  
  
  CONCLUSIONS
  In our study population hereditary prostate cancers have significantly lower Gleason scores compared to sporadic carcinomas. Otherwise, there appear to be no substantial clinical or pathological differences.
authors.affiliation: Division of Urologic Surgery, Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Keetch
authors.forename: P A
authors.initials: PA
authors.lastname: Humphrey
authors.forename: D S
authors.initials: DS
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Stahl
authors.forename: W J
authors.initials: WJ
authors.lastname: Catalona
mesh_terms: D017668:Age of Onset; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen