title: Epithelial cell proliferation in nasal polyps could be up-regulated by platelet-derived growth factor.
abstract: The modifications of epithelial differentiation and proliferation observed in nasal polyps (NP) could be related to local secretion of growth factors, among which platelet-derived growth factor (PDGF) could play a key role. We therefore prospectively studied, by immunohistochemistry, proliferating cell nuclear antigen (PCNA, an S-phase cell marker), PDGF, and CD-68 (activated macrophages marker) expression in NP and inferior turbinate mucosa (NM) in 11 patients. Our data show that PCNA and PDGF expression are increased in NP epithelium, while CD-68 expression is increased in NP epithelium and lamina propria when compared to NM. Increased local PDGF secretion by numerous activated macrophages could therefore be involved in epithelial cell proliferation up-regulation in NP. PDGF could also be involved in the pathogenesis of NP via its connective tissue remodeling actions.
authors.affiliation: Service d'ORL et de Chirurgue Cervico-Faciale, Hôpitaux Henri Mondor et Intercommunal de Créteil, France.
authors.forename: A
authors.initials: A
authors.lastname: Coste
authors.forename: Q P
authors.initials: QP
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Roudot-Thoraval
authors.forename: C
authors.initials: C
authors.lastname: Chapelin
authors.forename: P
authors.initials: P
authors.lastname: Bedbeder
authors.forename: F
authors.initials: F
authors.lastname: Poron
authors.forename: R
authors.initials: R
authors.lastname: Peynègre
authors.forename: E
authors.initials: E
authors.lastname: Escudier
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis; D002455:Cell Division; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology*; D009298:Nasal Polyps / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D011446:Prospective Studies; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD; D010982:Platelet-Derived Growth Factor; D018809:Proliferating Cell Nuclear Antigen