title: Somatostatin receptor scintigraphy in the initial staging of Hodgkin's disease.
abstract: Somatostatin receptor (SS-R) scintigraphy has been successfully used in the visualization of a variety of neuroendocrine tumours. In vitro studies have shown that SS-Rs are present in human malignant lymphomas. We conducted a prospective study in 56 consecutive untreated patients with histologically proven Hodgkin's disease (HD) and compared the results of SS-R scintigraphy with physical and radiological examinations as initial evaluation. SS-R scintigraphy was positive in 55/56 (98%) patients at sites of documented disease. In 20 patients SS-R scintigraphy disclosed lymphoma localizations not revealed following procedures of conventional staging. As a result in 12 patients (21%) SS-R scintigraphy produced a change of stage and in seven patients (13%) the additional information obtained from SS-R scintigraphy led to a change of treatment. SS-R scintigraphy failed to visualize sites of HD in four patients, mainly in the abdominal area. In three patients a false-positive result was obtained. These data show that SS-R scintigraphy provides an imaging technique that appears to visualize tumours in most patients with HD and may be clinically useful in the management of these patients.
authors.affiliation: Department of Haematology, Erasmus University, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van den Anker-Lugtenburg
authors.forename: E P
authors.initials: EP
authors.lastname: Krenning
authors.forename: H Y
authors.initials: HY
authors.lastname: Oei
authors.forename: M P
authors.initials: MP
authors.lastname: Van Hagen
authors.forename: C J
authors.initials: CJ
authors.lastname: Gerrits
authors.forename: J C
authors.initials: JC
authors.lastname: Reubi
authors.forename: S W
authors.initials: SW
authors.lastname: Lamberts
authors.forename: B
authors.initials: B
authors.lastname: Löwenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011859:Radiography; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis*; D012680:Sensitivity and Specificity
chemical_list: D017481:Receptors, Somatostatin