title: [Carboplatin and radical radiotherapy in the treatment of locally advanced urinary bladder carcinoma].
abstract: Our prospective nonrandomized study included 46 patients with invasive urinary bladder carcinoma of the clinical T3a and b stages. The patients were treated by radical radiotherapy (65 Gy, conventional fractioning) and by Carboplatin (150 mg per week during radiotherapy; total 900 mg). Of 35 patients for whom the response was evaluated, the complete regression of tumor was reached in 85.71% and partial in 5.7% of patients. Hematological toxicity of I and II grade was seen in 36/46 of patients. The average follow-up time was 9 months (interval 4-15), overall one year survival rate was 85%, and disease-free survival was 87%. The results have shown that simultaneous application of radical radiotherapy and Carboplatine promises the improvement in the treatment of the invasive urinary bladder carcinoma, but the short follow-up time does not allow the definitive conclusions.
authors.affiliation: Institut za onkologiju i radiologiju Srbije, Beograd.
authors.forename: L
authors.initials: L
authors.lastname: Radosević-Jelić
authors.forename: R
authors.initials: R
authors.lastname: Borkovacki
authors.forename: T
authors.initials: T
authors.lastname: Pekmezović
authors.forename: V
authors.initials: V
authors.lastname: Marković
authors.forename: V
authors.initials: V
authors.lastname: Petronić
mesh_terms: D000328:Adult; D000368:Aged; D016190:Carboplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D016190:Carboplatin