title: Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: the mouse homologs of genes responsible for glutaric acidemia type II in human.
abstract: Electron transfer flavoprotein (composed of alpha and beta subunits) is an obligatory electron acceptor for several dehydrogenases and is located in the mitochondrial matrix. Electrons accepted by electron transfer flavoprotein (ETF) are transferred to the main mitochondrial respiratory chain by way of ETF dehydrogenase (ETFDH). In humans, deficiency of ETF or ETFDH leads to glutaric acidemia type II, an inherited metabolic disorder that can be fatal in its neonatal form and is characterized by severe hypoketotic hypoglycemia and acidosis. We used cDNA probes for the Etfdh, Etfb, and Etfa genes to determine localization of these mouse genes to chromosomes 3, 7, and 13.
authors.affiliation: Section of Genetics, Children's Mercy Hospital, UMKC School of Medicine, Kansas City, Missouri, 64108, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: White
authors.forename: L L
authors.initials: LL
authors.lastname: Dowler
authors.forename: S V
authors.initials: SV
authors.lastname: Angeloni
authors.forename: D M
authors.initials: DM
authors.lastname: Koeller
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000235:genetics*; D000818:Animals; D002239:Carbohydrate Metabolism, Inborn Errors / Q000235:genetics; D002874:Chromosome Mapping; D044927:Electron-Transferring Flavoproteins; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005420:Flavoproteins / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D005977:Glutarates / Q000097:blood*; D006801:Humans; D007506:Iron-Sulfur Proteins; D051379:Mice; D009097:Multienzyme Complexes / Q000235:genetics*; D000587:Oxidoreductases Acting on CH-NH Group Donors
chemical_list: D044927:Electron-Transferring Flavoproteins; D005420:Flavoproteins; D005977:Glutarates; D007506:Iron-Sulfur Proteins; D009097:Multienzyme Complexes; D044943:Fatty Acid Desaturases; D000587:Oxidoreductases Acting on CH-NH Group Donors; C023120:electron-transferring-flavoprotein dehydrogenase; C035736:glutaric acid