Antioxidant properties of omeprazole.
Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 microM at pH 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCl scavenger ascorbate. Moreover, 10 and 50 microM OM inhibit significantly both iron- and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.
Lapenna
D
D
Istituto di Fisiopatologia Medica, Universitá degli Studi G.D. Annuzio, Chieti, Italy.
de Gioia
S
S
Ciofani
G
G
Festi
D
D
Cuccurullo
F
F
D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002338:Carotenoids / Q000378:metabolism; D002712:Chlorides; D003300:Copper / Q000494:pharmacology; D003855:Deoxyribose / Q000378:metabolism; D005290:Ferric Compounds / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D006997:Hypochlorous Acid / Q000494:pharmacology; D009853:Omeprazole / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D019207:beta Carotene
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D002712:Chlorides; D005290:Ferric Compounds; D019207:beta Carotene; D002338:Carotenoids; D003855:Deoxyribose; D006997:Hypochlorous Acid; D003300:Copper; D009853:Omeprazole; D001205:Ascorbic Acid; C029892:cupric chloride; C024555:ferric chloride