Antibody removal and subsequent transplantation of a highly sensitised paediatric renal patient.
We report a successful renal transplant in a highly sensitised paediatric recipient following removal of HLA-specific antibodies by extracorporeal immunoadsorption. The immediate pretransplant cytotoxic titre against the donor was greater than 1:512; this was reduced to negativity by two immunoadsorption sessions prior to transplant surgery. We also describe the presence of unexpected non-HLA-specific antibody activities in this immunoadsorbed patient.
Bevan
D J
DJ
South Thames Regional Tissue Typing Laboratory, Guy's Hospital, London, UK.
Carey
B S
BS
Lea
C K
CK
Vaughan
R W
RW
Rigden
S P
SP
Higgins
R M
RM
Hendry
B N
BN
Koffman
C G
CG
Bewick
M
M
D001323:Autoantibodies; D002648:Child; D006084:Graft Rejection / Q000276:immunology / Q000628:therapy*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007164:Immunosorbents; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D006435:Renal Dialysis / Q000379:methods*
D001323:Autoantibodies; D006680:HLA Antigens; D007164:Immunosorbents