Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency.
We used a system capable of measuring conjugated bilirubin and its monoconjugated and diconjugated fractions in serum to assess bilirubin conjugation in 29 glucose-6-phosphate dehydrogenase (G6PD)-deficient, term, male newborn infants and 35 control subjects; all had serum bilirubin levels > or = 256 mumol/L (15 mg/dI). The median value for diconjugated bilirubin was lower in the G6PD-deficient neonates than in control subjects (0.06 (range 0.00 to 1.84) vs 0.21 (range 0.00 to 1.02) mumol/L, p = 0.006). Diglucuronide was undetectable in 11 (38.9%) of the G6PD-deficient infants versus 3 (8.6%) of the control subjects (p = 0.015). These findings imply a partial defect of bilirubin conjugation not previously demonstrated in G6PD-deficient newborn infants.
Kaplan
M
M
Department of Neonatology, Shaare Zedek Medical Center, Medical School, Hebrew University-Hadassah, Jerusalem, Israel.
Rubaltelli
F F
FF
Hammerman
C
C
Vilei
M T
MT
Leiter
C
C
Abramov
A
A
Muraca
M
M
D001663:Bilirubin / Q000097:blood*; D001724:Birth Weight; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005865:Gestational Age; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D001663:Bilirubin