[Novel targets for cancer chemotherapy].
Data resulting from new insights into targets for cancer chemotherapy have been stored after the educational symposium entitled "Novel Targets for Cancer Therapy" was held at the 27th Annual Meeting of the American Society of Clinical Oncology in 1991. Novel targets for cancer chemotherapy, which have been found or assessed to be useful after the meeting, are summarized. The contents are as follows: 1) inhibitors of signal transduction pathway, 2) inducers of apoptosis and/or differentiation, 3) agents acting on DNA directly and indirectly, 4) inhibitors of telomerase, 5) agents acting on cytoplasmic microorgans, 6) inhibitors of cytoplasmic metabolism, 7) modulators of multidrug resistance, and 8) unknown or complex targets of drug action. Targets described in each passage may be applicable to the development of new anticancer agents. Agents acting on the targets have been optionally chosen and listed. The significance of important targets and agents in cancer chemotherapy is described in more detail.
Inoue
S
S
Department of Environmental Medicine and Informatics, Graduate School of Environmental Earth Science, Hokkaido University, Japan.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D004273:DNA, Neoplasm / Q000187:drug effects; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015388:Organelles / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D019098:Telomerase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D019098:Telomerase