title: Nisin stimulates oxygen consumption by Staphylococcus aureus and Escherichia coli.
abstract: Nisin stimulated oxygen consumption by nongrowing, glucose-metabolizing Staphylococcus aureus and Escherichia coli cells, indicating a protonophore mode of action. A similar stimulation in E. coli cells osmotically stressed to disrupt the outer cell membrane confirmed the cytoplasmic membrane as the site of nisin action and showed that nisin uptake was not prevented by the outer membrane.
authors.affiliation: Division of Life Sciences, King's College London, United Kingdom. UDLI163@hazel.cc.kcl.ac.uk
authors.forename: A M
authors.initials: AM
authors.lastname: Carneiro de Melo
authors.forename: G M
authors.initials: GM
authors.lastname: Cook
authors.forename: R J
authors.initials: RJ
authors.lastname: Miles
authors.forename: R K
authors.initials: RK
authors.lastname: Poole
mesh_terms: D004926:Escherichia coli / Q000378:metabolism*; D005520:Food Preservatives / Q000494:pharmacology*; D009561:Nisin / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D013211:Staphylococcus aureus / Q000378:metabolism*
chemical_list: D005520:Food Preservatives; D009561:Nisin