title: Extracts of Ginkgo biloba leaves inhibit monoamine oxidase.
abstract: Extracts of Ginkgo biloba leaves produce reversible inhibition of rat brain monoamine (MAO). Both MAO-A and -B types were inhibited to a similar extent. The MAO inhibitory compound(s) were present in dried or fresh Ginkgo biloba leaves as well as in commercially available capsules of Ginkgo biloba and appear to be heat stable with relatively low molecular weight. MAO inhibition by Ginkgo biloba may be a mechanism underlying reported anti-stress and anxiolytic activities of this natural product.
authors.affiliation: Division of Pharmacology, Burroughs Wellcome Co, Research Triangle Park, NC 27709, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: White
authors.forename: P W
authors.initials: PW
authors.lastname: Scates
authors.forename: B R
authors.initials: BR
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D010936:Plant Extracts