title: Quality of life in long-term survivors of marrow transplantation: comparison with a matched group receiving maintenance chemotherapy.
abstract: A retrospective descriptive study was designed to assess the quality of life (QoL) and psychosocial adjustment in long-term BMT survivors compared with a group of patients with haematological malignancies receiving maintenance chemotherapy (MC), matched for age, post-treatment time, sociodemographic and disease characteristics. The sample consisted of 91 long-term BMT survivors and 73 MC patients from three teaching hospitals in the UK. The results indicated that most of the BMT subjects had a good to excellent quality of life and, in some domains, even better adjustment than the MC patients. However, 20% of the BMT subjects had failed to return to full-time employment at a mean post-BMT time of almost 40 months. A significant number of BMT subjects were also identified with symptoms of anxiety and depression. The physical symptomatology had an association with psychological status. Impotence-related difficulties, decreased sexual satisfaction and altered body image were the main characteristics of psychosexual dysfunction in the BMT group. Poorer quality of life was predicted by the presence of depressive symptoms, low affirmation, and impoverished social adjustment.
authors.affiliation: Department of Nursing Studies, Medical School, University of Birmingham, UK.
authors.forename: A
authors.initials: A
authors.lastname: Molassiotis
authors.forename: O B
authors.initials: OB
authors.lastname: van den Akker
authors.forename: D W
authors.initials: DW
authors.lastname: Milligan
authors.forename: J M
authors.initials: JM
authors.lastname: Goldman
authors.forename: B J
authors.initials: BJ
authors.lastname: Boughton
authors.forename: J A
authors.initials: JA
authors.lastname: Holmes
authors.forename: S
authors.initials: S
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001007:Anxiety / Q000453:epidemiology; D001828:Body Image; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000523:psychology / Q000534:rehabilitation; D003863:Depression / Q000453:epidemiology; D005260:Female; D006402:Hematologic Diseases / Q000188:drug therapy / Q000523:psychology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology; D012917:Social Adjustment; D012944:Social Support; D017741:Survivors / Q000523:psychology*; D014478:Unemployment