Detection of fibrin in canine neoplasia.
A murine monoclonal antibody, designated 1H10, produced using a human fibrin-related immunogen, was shown to bind avidly to dog fibrin, but not to dog fibrinogen. Using immunofluorescence, fibrin was detected in canine gastric adenocarcinoma and in mixed tissue from a mammary tumour. No fibrin could be detected in bronchogenic carcinoma tissue.
McEvoy
F J
FJ
Royal Veterinary College, University of London, North Mymms, Hatfield, UK.
Edgell
T A
TA
Webbon
P M
PM
Gaffney
P J
PJ
D000230:Adenocarcinoma / Q000097:blood / Q000662:veterinary*; D000818:Animals; D000911:Antibodies, Monoclonal; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005337:Fibrin / Q000032:analysis*; D006801:Humans; D013274:Stomach Neoplasms / Q000097:blood / Q000662:veterinary*
D000911:Antibodies, Monoclonal; D005337:Fibrin