title: Antibody removal and subsequent transplantation of a highly sensitised paediatric renal patient.
abstract: We report a successful renal transplant in a highly sensitised paediatric recipient following removal of HLA-specific antibodies by extracorporeal immunoadsorption. The immediate pretransplant cytotoxic titre against the donor was greater than 1:512; this was reduced to negativity by two immunoadsorption sessions prior to transplant surgery. We also describe the presence of unexpected non-HLA-specific antibody activities in this immunoadsorbed patient.
authors.affiliation: South Thames Regional Tissue Typing Laboratory, Guy's Hospital, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Bevan
authors.forename: B S
authors.initials: BS
authors.lastname: Carey
authors.forename: C K
authors.initials: CK
authors.lastname: Lea
authors.forename: R W
authors.initials: RW
authors.lastname: Vaughan
authors.forename: S P
authors.initials: SP
authors.lastname: Rigden
authors.forename: R M
authors.initials: RM
authors.lastname: Higgins
authors.forename: B N
authors.initials: BN
authors.lastname: Hendry
authors.forename: C G
authors.initials: CG
authors.lastname: Koffman
authors.forename: M
authors.initials: M
authors.lastname: Bewick
mesh_terms: D001323:Autoantibodies; D002648:Child; D006084:Graft Rejection / Q000276:immunology / Q000628:therapy*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007164:Immunosorbents; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens; D007164:Immunosorbents