Increased proliferation of eosinophil clusters in myelodysplastic syndromes.
A patient with myelodysplastic syndromes (MDS) developed eosinophilia during treatment with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). To study the mechanism of this eosinophilia, we investigated the proliferation of eosinophil colony-forming units (CFU-Eo) in nine patients and four healthy controls. Eosinophil clusters increased significantly in the patients (P < 0.01) compared with controls, but eosinophil colonies were not different between controls and MDS patients. In addition, the eosinophil clusters were significantly increased with rhGM-CSF in MDS patients compared with controls, although serum GM-CSF concentrations were similar in both groups. These results suggest that eosinophil clusters are increased in MDS either through abnormal progenitor proliferation or hypersensitivity to GM-CSF.
Koike
M
M
Department of Hematology, Showa University School of Medicine, Tokyo, Japan.
Ishiyama
T
T
Yokoyama
A
A
Kawakami
K
K
Nakamaki
T
T
Tomoyasu
S
S
Tsuruoka
N
N
D000368:Aged; D000753:Anemia, Refractory / Q000473:pathology / Q000628:therapy; D001853:Bone Marrow / Q000473:pathology*; D002455:Cell Division; D003114:Colony-Forming Units Assay; D004802:Eosinophilia / Q000209:etiology / Q000473:pathology; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007377:Interleukin-3 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000473:pathology*; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use
D007377:Interleukin-3; D015848:Interleukin-5; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor