title: Paraneoplastic pemphigus in a patient with non-Hodgkin's lymphoma.
abstract: Paraneoplastic pemphigus (PNP) is an autoimmune disorder occurring in the setting of an underlying neoplasm in which patients have polymorphous skin and mucous membrane lesions. We describe a patient with non-Hodgkin's lymphoma who developed bullous, ulcerating lesions in an area being treated with radiation therapy. The diagnosis of PNP was confirmed by indirect immunofluorescence of the patient's serum on rat bladder. The disorder was refractory to therapy, and ultimately the patient expired.
authors.affiliation: Division of Clinical Oncology, University of Kansas Medical Center, Kansas City 66160-7353, USA.
authors.forename: R
authors.initials: R
authors.lastname: Plumb
authors.forename: G C
authors.initials: GC
authors.lastname: Doolittle
mesh_terms: D000368:Aged; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis; D004892:Erythema Multiforme / Q000175:diagnosis; D017809:Fatal Outcome; D019084:Fluorescent Antibody Technique, Indirect; D006562:Herpes Zoster / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008224:Lymphoma, Follicular / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D009364:Neoplasm Recurrence, Local; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy; D010392:Pemphigus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy; D010956:Plasmapheresis; D011129:Polyradiculoneuropathy / Q000150:complications / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D051381:Rats; D001743:Urinary Bladder
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine