title: One-session management of cervical intraepithelial neoplasia: a solution for developing countries.
abstract: Six hundred thirty-nine patients with CIN on referral Pap were evaluated cytocolposcopically at the first visit and decided whether to be treated the same day or not. One hundred ninety-two patients (30%) were considered negative. Follow-up evidenced later appearance of CIN in five of them. One hundred fifty-three (24%) were candidates for delayed treatment due to conditions contraindicating same-day treatment. Two hundred ninety-four patients (46%) were randomly allocated in LEEP (149) or excisional laser (145) arms, and treated the same day under local anesthesia. Both arms were comparable. There were three microinvasive carcinomas diagnosed in the surgical specimen. LEEP was faster and produced less bleeding than laser, although required a mean of four slices to remove the lesion. Arterial hypertension after anesthetic infiltration was detected in 26% of cases. Two intraoperative and two delayed bleeders required surgery. The size of lesion and surgical defect were larger than those reported in the literature. Margins were involved in 8 patients (2.7%). Only 4.7% (7/149) of patients randomized to LEEP and 3.4% (5/145) with excisional laser had persistent or recurrent CIN on follow-up. Factors predisposing to failure included depth of surgical defect, grade of lesion, and operator's expertise. With this approach, 69% of patients referred for cytology of CIN were adequately managed in the first visit, which contrasts to classical management that reaches the state of treatment in 30% of patients. LEEP appears to be faster, less costly, and requires less expertise. Its use in conjunction with adequate screening is recommended for developing countries.
authors.affiliation: Department of Gynecology, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.forename: R
authors.initials: R
authors.lastname: Galdos
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: C
authors.initials: C
authors.lastname: Velarde
authors.forename: O
authors.initials: O
authors.lastname: Barriga
authors.forename: R
authors.initials: R
authors.lastname: Dyer
authors.forename: H
authors.initials: H
authors.lastname: Estrada
authors.forename: M
authors.initials: M
authors.lastname: Almonte
mesh_terms: D019092:Conization; D003906:Developing Countries; D004598:Electrosurgery; D005260:Female; D006801:Humans; D053685:Laser Therapy; D018365:Neoplasm, Residual / Q000473:pathology; D010352:Patient Dropouts; D011183:Postoperative Complications; D011446:Prospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000628:therapy*; D002578:Uterine Cervical Dysplasia / Q000628:therapy*