title: Efficacy and safety of oral iron chelating agent deferiprone in beta-thalassemia and hemoglobin E-beta thalassemia.
abstract: OBJECTIVE
  To assess efficacy and safety of oral iron chelating agent deferiprone (DFP) in patients with beta thalassemia and hemoglobin E-beta thalassemia.
  
  
  METHODS
  Non-randomized study.
  
  
  METHODS
  Hematology Out-Patient Department.
  
  
  METHODS
  Forty-one patients of beta thalassemia and hemoglobin E-beta thalassemia.
  
  
  METHODS
  DFP was given to 20 patients, 10 patients of beta thalassemia and 10 with hemoglobin E-beta thalassemia; the rest were taken as controls.
  
  
  RESULTS
  A significant fall in serum ferritin was observed in the study group along with rise in urinary iron excretion (p < 0.05). Adverse effects of DFP were nausea and vomiting (30%), significant arthropathy requiring stopping of the drug (30%), and reversible neutropenia in one patient. All these complications could be managed easily with medical supervision and no death or permanent disability was seen.
  
  
  CONCLUSIONS
  DFP is an effective and fairly well tolerated oral iron chelating agent. The side effects that occur can be tackled easily if monitored properly.
authors.affiliation: Department of Hematology, Kothari Institute of Medical Science, Jadavpur University, Calcutta.
authors.forename: D
authors.initials: D
authors.lastname: Adhikari
authors.forename: T B
authors.initials: TB
authors.lastname: Roy
authors.forename: A
authors.initials: A
authors.lastname: Biswas
authors.forename: M L
authors.initials: ML
authors.lastname: Chakraborty
authors.forename: B
authors.initials: B
authors.lastname: Bhattacharya
authors.forename: T K
authors.initials: TK
authors.lastname: Maitra
authors.forename: A K
authors.initials: AK
authors.lastname: Basu
authors.forename: S
authors.initials: S
authors.lastname: Chandra
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D000077543:Deferiprone; D005260:Female; D006446:Hemoglobin E / Q000187:drug effects; D006801:Humans; D007194:India; D007501:Iron / Q000097:blood; D008297:Male; D010349:Patient Compliance; D011728:Pyridones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017086:beta-Thalassemia / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D002614:Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D006446:Hemoglobin E; D007501:Iron