title: IgG anti-50 kd lymphocyte membrane peptide antibody in patients with Sézary syndrome.
abstract: BACKGROUND
  Recent evidence suggests that as cutaneous T-cell lymphoma progresses, cell-mediated immunity is reduced and humoral responses are augmented.
  
  
  OBJECTIVE
  The present study was designed to compare the IgG response in Sézary syndrome with that in mycosis fungoides.
  
  
  METHODS
  The IgG antilymphocyte response was studied in six patients with Sézary syndrome and in 11 patients with mycosis fungoides by means of immunoblot analysis, enzyme-linked immunosorbent assay, immunohistochemistry, and flow cytometry.
  
  
  RESULTS
  An IgG antilymphocyte response to a 50 kd peptide was seen in five of the six patients with Sézary syndrome; however, none of the 11 patients with mycosis fungoides expressed this response.
  
  
  CONCLUSIONS
  An enhanced IgG immune response to 50 kd lymphocyte peptide may be helpful in identifying disease progression in patients with cutaneous T-cell lymphoma.
authors.affiliation: University of Pittsburgh Department of Dermatology, PA, USA.
authors.forename: K
authors.initials: K
authors.lastname: D'Ambra-Cabry
authors.forename: M D
authors.initials: MD
authors.lastname: Tharp
authors.forename: B V
authors.initials: BV
authors.lastname: Jagasothy
authors.forename: J S
authors.initials: JS
authors.lastname: Deng
mesh_terms: D000328:Adult; D000912:Antibodies, Neoplasm / Q000276:immunology*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007111:Immunity, Cellular; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology; D009182:Mycosis Fungoides / Q000276:immunology / Q000473:pathology; D012751:Sezary Syndrome / Q000276:immunology* / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D000912:Antibodies, Neoplasm; D007074:Immunoglobulin G; D008565:Membrane Proteins