title: Regulation of peptide YY homeostasis by gastric acid and gastrin.
abstract: Peptide YY (PYY) is a gut hormone localized primarily in the distal bowel. Because circulating PYY inhibits gastric acid secretion, we investigated the effects of gastric acid secretion and gastrin on gene expression and secretion of PYY. In conscious dogs, PYY release in response to oral food was inhibited (P < 0.05) by pharmacologic inhibition of gastric acid secretion (omeprazole, famotidine). In rats, omeprazole treatment resulted in a significant elevation in serum gastrin concentrations and a simultaneous decrease in PYY messenger RNA (mRNA) and peptide levels in the colon; administration of a gastrin receptor antagonist (L365, 260) prevented the inhibitory actions of omeprazole on colonic PYY mRNA levels. In athymic-nude mice, implantation of a human gastrinoma resulted in an elevation of serum gastrin concentrations and a concomitant depression of colonic PYY mRNA levels. We conclude that endogenous gastric acid secretion up-regulates PYY release and PYY mRNA expression. Circulating gastrin acts to down-regulate PYY release and PYY mRNA expression. This study provides evidence that foregut functions (i.e., gastric acid secretion and gastrin release) exert control over an antiacid signal (e.g. PYY release) emanating from the hindgut.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston, 77555, USA.
authors.forename: G
authors.initials: G
authors.lastname: Gomez
authors.forename: L
authors.initials: L
authors.lastname: Padilla
authors.forename: V
authors.initials: V
authors.lastname: Udupi
authors.forename: N
authors.initials: N
authors.lastname: Tarasova
authors.forename: F
authors.initials: F
authors.lastname: Sundler
authors.forename: C M
authors.initials: CM
authors.lastname: Townsend
authors.forename: J C
authors.initials: JC
authors.lastname: Thompson
authors.forename: G H
authors.initials: GH
authors.lastname: Greeley
mesh_terms: D000818:Animals; D004285:Dogs; D015738:Famotidine / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D015408:Gastrinoma / Q000378:metabolism; D005755:Gastrins / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000378:metabolism; D015870:Gene Expression; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009853:Omeprazole / Q000494:pharmacology; D019894:Peptide YY; D010455:Peptides / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005755:Gastrins; D005768:Gastrointestinal Hormones; D010455:Peptides; D012333:RNA, Messenger; D019894:Peptide YY; D015738:Famotidine; D009853:Omeprazole