Antioxidants in pediatric gastrointestinal disease.
Oxidant stress seems to be involved in the pathogenesis of several important gastroenterologic disorders in infants and children. The question can still be asked, in most circumstances, whether the oxidant stress precedes, and therefore is involved in, tissue or cellular injury or is a result of injury and not of clinical importance. The data favor the former situation in several inflammatory conditions of the bowel and in a variety of liver diseases. Experimental and clinical testing of this possible basic mechanism of tissue injury over the next few years will shed light on the role of antioxidants in treating gastrointestinal disorders.
Sokol
R J
RJ
Pediatric Liver Center, University of Colorado School of Medicine, Denver, USA.
Hoffenberg
E J
EJ
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D005609:Free Radicals / Q000009:adverse effects; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D010586:Phagocytes / Q000276:immunology; D017382:Reactive Oxygen Species / Q000009:adverse effects*
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D017382:Reactive Oxygen Species