title: Six-month follow-up of naltrexone and psychotherapy for alcohol dependence.
abstract: BACKGROUND
  The goal of this study was to examine the persistence of naltrexone's effects on drinking outcomes among alcoholics following discontinuation of treatment and to determine whether coping skills therapy improves long-term outcomes compared with supportive therapy.
  
  
  METHODS
  Eighty of 97 alcohol-dependent subjects randomized to receive naltrexone or placebo and either coping skills therapy or supportive therapy for 12 weeks were assessed at a 6-month off-treatment follow-up.
  
  
  RESULTS
  Subjects who received naltrexone were less likely to drink heavily or to meet criteria for alcohol abuse or dependence than subjects who received placebo. The effect of naltrexone therapy on abstinence rates persisted only through the first month of follow-up. Coping skills therapy was associated with decreased levels of drinking among subjects who received placebo. Psychotherapy condition, however, did not predict alcohol diagnosis at follow-up.
  
  
  CONCLUSIONS
  Some but not all of the benefits resulting from short-term naltrexone treatment persist after discontinuation of treatment. The findings suggest that continued treatment with naltrexone may be beneficial for some patients.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: O'Malley
authors.forename: A J
authors.initials: AJ
authors.lastname: Jaffe
authors.forename: G
authors.initials: G
authors.lastname: Chang
authors.forename: S
authors.initials: S
authors.lastname: Rode
authors.forename: R
authors.initials: R
authors.lastname: Schottenfeld
authors.forename: R E
authors.initials: RE
authors.lastname: Meyer
authors.forename: B
authors.initials: B
authors.lastname: Rounsaville
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy; D000437:Alcoholism / Q000188:drug therapy / Q000534:rehabilitation / Q000628:therapy*; D001521:Behavior Therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use*; D010919:Placebos; D011613:Psychotherapy; D012044:Regression Analysis; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D009271:Naltrexone