Formulae and tables for the determination of sample sizes and power in clinical trials for testing differences in proportions for the two-sample design: a review.
This paper is a compendium of exact and asymptotic formulae and tables for estimating the sample size in a clinical trial with two treatment groups and a dichotomous outcome. The paper provides separate formulae for equal and unequal treatment group sizes, formulae for the calculation of power given the sample size, and complete references for all formulae and tables cited.
Sahai
H
H
Department of Biostatistics and Epidemiology, University of Puerto Rico, Medical Sciences Campus, San Juan, USA.
Khurshid
A
A
D016010:Binomial Distribution; D016009:Chi-Square Distribution; D018849:Controlled Clinical Trials as Topic; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D006801:Humans; D016011:Normal Distribution; D016017:Odds Ratio; D016012:Poisson Distribution; D012107:Research Design; D012306:Risk; D018401:Sample Size; D016896:Treatment Outcome