title: Prognostic significance of Ki-67 labeling index in urothelial tumors of the renal pelvis and ureter.
abstract: OBJECTIVE
  We evaluated the prognostic significance of the Ki-67 labeling index in 70 patients with primary urothelial tumors of the renal pelvis and ureter.
  
  
  METHODS
  Immunohistochemical staining for Ki-67 in archival tumor materials was done by the streptavidin-biotin method.
  
  
  RESULTS
  Univariate survival analysis showed that the prognosis of patients with a high Ki-67 labeling index of 21.7 or more was significantly worse than that of patients with an intermediate labeling index of 13.3 to less than 21.7 (p < 0.01) or a low labeling index of less than 13.3 (p < 0.001). Multivariate survival analysis showed that staining for Ki-67 labeling index was significantly correlated with prognosis (p < 0.01).
  
  
  CONCLUSIONS
  Analysis of Ki-67 labeling index provides useful prognostic information about patients with primary urothelial tumors of the renal pelvis and ureter.
authors.affiliation: Department of Urology, Yokohama City University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Masuda
authors.forename: M
authors.initials: M
authors.lastname: Iki
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: T
authors.initials: T
authors.lastname: Asakura
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: I
authors.initials: I
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: M
authors.initials: M
authors.lastname: Hosaka
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000401:mortality*; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D007680:Kidney Neoplasms / Q000276:immunology / Q000401:mortality*; D007682:Kidney Pelvis / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D014513:Ureter / Q000737:chemistry; D014516:Ureteral Neoplasms / Q000276:immunology / Q000401:mortality*
chemical_list: D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins