Congenital anomalies of the hand. The Asian perspective.
To have a better understanding of teratogenic mechanisms of congenital absence of digits, ulnar and radial deficiencies, cleft hand, and symbrachydactyly were analyzed in clinical cases. The same anomalies were induced in rat fetuses by busulfan, and their characteristics were investigated. The formation process of longitudinal deficiency also was observed histologically. There seemed to be 4 teratogenic mechanisms of congenital absence of digits. Ulnar and radial deficiencies have the same clinical features, and the cause of these deficiencies is related closely to a deficit of mesenchymal cells in the limb bud caused by the impairment before the formation of the limb bud. Cleft hand, central polydactyly, and osseous syndactyly were induced by the same treatment at the same developmental stage in rats. Cleft hand formation process from osseous syndactylies and central polydactylies was supposed. The teratogenic mechanism of cleft hand seemed to be failure of induction of digital rays in the hand plate. The sequence of anomalies from brachysyndactyly, or the atypical cleft hand, to the transverse deficiency can be regarded as equivalent to the category of bony dysplasia of the hand. Congenital constriction ring syndrome does appear after the formation of the digital rays.
Ogino
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Department of Physical Therapy, School of Health Sciences, Sapparo Medical University, Japan.
D000818:Animals; D002066:Busulfan / Q000633:toxicity; D005385:Fingers / Q000002:abnormalities; D006228:Hand Deformities, Congenital / Q000145:classification / Q000473:pathology; D006801:Humans; D011884:Radius / Q000002:abnormalities; D051381:Rats; D013576:Syndactyly / Q000145:classification / Q000473:pathology; D013723:Teratogens / Q000633:toxicity; D014457:Ulna / Q000002:abnormalities
D013723:Teratogens; D002066:Busulfan