title: Adverse effects of medications on urinary symptoms and flow rate: a community-based study.
abstract: The relationship between urinary symptoms and medication use was investigated in a community-based cross-sectional study involving a random sample of 2115 men 40-79 years of age in Olmsted County, Minnesota. The American Urological Association Symptom Index (AUASI) was generated from a validated self-administered questionnaire. Medication use was assessed by in-person interviews. While 1087 men reported daily medication use, only 136 reported daily use of medications known to affect urinary function adversely, including antidepressants (42), antihistamines (23), and bronchodilators (43). Age-adjusted AUASI scores were higher in men reporting daily use of antidepressants, and the association persisted after additionally adjusting for the Depression and Anxiety subscales of the General Psychological Well-Being Scale (adjusted mean difference, 2.1; 95% confidence interval (CI), 0.5-3.6; p = 0.008). The adjusted AUASI was also higher among men who took antihistamines daily (adjusted mean difference, 2.3; 95% CI, 0.3-4.3; p = 0.03). Lower age-adjusted urinary flow rates occurred with antidepressants, but not with antihistamines or bronchodilators. Clinicians evaluating men for causes of voiding dysfunction in accordance with the Agency for Health Care Policy and Research practice guideline for the diagnosis and management of benign prostatic hyperplasia should be aware that daily use of antidepressants or antihistamines may be associated with AUASI scores that are two to three points higher than in men not taking these medications.
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill 27599-7400, USA.
authors.forename: L
authors.initials: L
authors.lastname: Su
authors.forename: H A
authors.initials: HA
authors.lastname: Guess
authors.forename: C J
authors.initials: CJ
authors.lastname: Girman
authors.forename: S J
authors.initials: SJ
authors.lastname: Jacobsen
authors.forename: J E
authors.initials: JE
authors.lastname: Oesterling
authors.forename: L A
authors.initials: LA
authors.lastname: Panser
authors.forename: M M
authors.initials: MM
authors.lastname: Lieber
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D001993:Bronchodilator Agents / Q000009:adverse effects*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006304:Health Status; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014551:Urinary Tract / Q000187:drug effects*; D014554:Urination / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D001993:Bronchodilator Agents; D006634:Histamine H1 Antagonists