Lipoprotein(a) and oxygen free radicals in survivors of acute myocardial infarction: effects of captopril.
Long-term treatment of survivors of an acute myocardial infarction with angiotensin-converting enzyme inhibitors has a beneficial impact on their long-term outcome. We tested the hypothesis that captopril could reductively cleave the lipoprotein(a) molecule and in addition act as a scavenger of oxygen free radicals. In a double-blind trial, 20 patients were randomized to receive either captopril 50 mg daily or corresponding placebo. patients were followed for a period of 30 days. Blood samples were drawn prior to randomization and after 30 days of treatment. Plasma concentrations of lipoprotein(a) and malondialdehyde were evaluated. Captopril treatment produced a significant reduction in plasma content of lipoprotein(a) ( < 0.05) and at day 30 the plasma content of lipoprotein(a) was also significantly lower than that in the placebo group (p < 0.05). furthermore, on day 30 plasma concentrations of malondialdehyde, an indicator of oxidative damage, were significantly lower in the captopril group when compared to baseline values and corresponding placebo group values (p < 0.05). The observed effect of captopril treatment on lipoprotein(a) and malondialdehyde might be ascribed to the sulfhydryl group in the captopril molecule.
Søgaard
P
P
Department of Cardiology, Aarhus University Hospital, Denmark.
Klausen
I C
IC
Rungby
J
J
Faergeman
O
O
Thygesen
K
K
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005609:Free Radicals / Q000097:blood; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D010100:Oxygen / Q000097:blood; D017741:Survivors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D005609:Free Radicals; D017270:Lipoprotein(a); D008315:Malondialdehyde; D002216:Captopril; D010100:Oxygen