title: Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: evaluation of current treatment.
abstract: The postantibiotic effects (PAEs) OF 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The beta-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: A L
authors.initials: AL
authors.lastname: Walsh
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: V
authors.initials: V
authors.lastname: Wuthiekanun
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016957:Burkholderia pseudomallei / Q000187:drug effects*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D008554:Melioidosis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents