Inhibition of angiogenesis and murine tumour growth by laminarin sulphate.
LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).
Hoffman
R
R
Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.
Paper
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Donaldson
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Vogl
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D002417:Cattle; D002478:Cells, Cultured; D002642:Chick Embryo; D003094:Collagen; D004338:Drug Combinations; D004730:Endothelium, Vascular / Q000166:cytology; D007797:Laminin; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D008969:Molecular Sequence Data; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D011509:Proteoglycans
D000970:Antineoplastic Agents; D004338:Drug Combinations; D007797:Laminin; D011134:Polysaccharides; D011509:Proteoglycans; C059485:matrigel; D003094:Collagen; C053460:laminarin sulfate