Scavenging effects of phenylpropanoid glycosides from Pedicularis on superoxide anion and hydroxyl radical by the spin trapping method(95)02255-4.
The scavenging activities of six phenylpropanoid glycosides, i.e. leucosceptoside A and martynoside, isolated from Pedicularis alashanica Maxim, verbascoside, and pediculariosides A, M and N isolated from Pedicularis striata Pall ssp. arachnoidea Franch Tsoong, on superoxide anion and hydroxyl radicals have been studied by the spin trapping method. The results demonstrated that the number of phenolic hydroxyl groups in the structures of the phenylpropanoid glycosides is related to their scavenging activities. The scavenging effects of the phenylpropanoid glycosides possessing two o-dihydroxyl groups were stronger than the effects of the compounds possessing two o-hydroxy-methoxy groups.
Wang
P
P
Department of Biology, Lanzhou University, China.
Kang
J
J
Zheng
R
R
Yang
Z
Z
Lu
J
J
Gao
J
J
Jia
Z
Z
D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism*; D013113:Spin Labels; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism*
D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D006027:Glycosides; D013113:Spin Labels; D013481:Superoxides; D017665:Hydroxyl Radical; C017245:5,5-dimethyl-1-pyrroline-1-oxide