title: Mortality and neurologic morbidity after repair of traumatic aortic disruption.
abstract: BACKGROUND
  Traumatic disruption of the thoracic aorta frequently results in death before operative repair. The determinants of mortality after repair, however, are uncertain. In addition, intraoperative strategies for reducing the incidence of spinal cord injury remain controversial.
  
  
  METHODS
  The records of 45 consecutive patients undergoing repair of traumatic disruption of the thoracic aorta at a single institution during a 9-year period were reviewed in a retrospective fashion. Patient age ranged from 15 to 81 years (mean age, 33.9 years). Twenty-two patients (49%) had multiple associated injuries, and 8 (18%) had isolated aortic injuries. Nine patients (20%) experienced preoperative hypotension (systolic blood pressure of less than 90 mm Hg). Repair was performed with partial bypass in 22 patients, a heparinized shunt in 2, and no distal perfusion (clamp and sew technique) in 21.
  
  
  RESULTS
  Nine patient (20%) died after operation. Multivariate logistic regression analysis of preoperative and intraoperative variables identified advancing age and preoperative hypotension as independent predictors of operative death. The presence of associated injuries was not an independent predictor of operative death. All 4 patients with injuries proximal to the aortic isthmus died. Ten patients were excluded from analysis of spinal cord injury either because of preoperative neurologic deficit or because of death before postoperative evaluation. Six (17%) of the remaining 35 patients had development of paraplegia: 5 of the 15 patients having the clamp and sew technique, 1 of the 2 with a shunt, and 0 of the 18 patients with bypass (p < 0.05, clamp and sew versus bypass). In the clamp and sew group, patients in whom paraplegia developed had significantly longer aortic clamp times than those without neurologic injury (40.6 +/- 4.4 minutes versus 28.7 +/- 2.9 minutes, respectively; p < 0.05).
  
  
  CONCLUSIONS
  Advancing age, preoperative hypotension, and perhaps injury location are important determinants of death after repair of traumatic disruption of the thoracic aorta. Adjunctive perfusion with partial bypass should be used during repair to reduce the incidence of spinal cord injury.
authors.affiliation: Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Nocolosi
authors.forename: G H
authors.initials: GH
authors.lastname: Almassi
authors.forename: M
authors.initials: M
authors.lastname: Bousamra
authors.forename: G B
authors.initials: GB
authors.lastname: Haasler
authors.forename: G N
authors.initials: GN
authors.lastname: Olinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000293:injuries* / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000401:mortality; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010264:Paraplegia / Q000209:etiology; D011183:Postoperative Complications / Q000401:mortality; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000209:etiology* / Q000401:mortality; D016019:Survival Analysis