title: Results of irradiation treatment in patients with non-resectable oesophageal cancer.
abstract: Forty-eight patients with non-resectable cancer of the oesophagus and oesophagogastric junction (Group A: Stage I/II, 32; Group B: Stage III/IV, 16) underwent intraluminal Iridium-192 high dose-rate afterloading therapy (5-7 Gy/session, total dose: 5-21 Gy, mean: 12.4 Gy) and external beam irradiation (Karnofsky > or = 80% 50-60 Gy/2 Gy per day; Karnofsky 60-79%: 30 Gy/3 Gy per day). Durable satisfactory palliation (intake of at least semi-solid food) was demonstrated in 96% of patients. The mean survival for group A was 19.1 months and that for group B, 6.9 months, with a 12-month survival rate of 66% (group A) and 0% (group B) (P < 0.001). Local tumour response and complication rate were significantly dose-related with a predicted response rate of 70.5%, and a complication rate of 50% at ERD 129.3 Gy.
authors.affiliation: Department of Surgery, University of Graz, Austria.
authors.forename: P H
authors.initials: PH
authors.lastname: Kohek
authors.forename: B
authors.initials: B
authors.lastname: Pakisch
authors.forename: H
authors.initials: H
authors.lastname: Glanzer
authors.forename: G
authors.initials: G
authors.lastname: Höss
authors.forename: H J
authors.initials: HJ
authors.lastname: Mischinger
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: P
authors.initials: P
authors.lastname: Steindorfer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects; D004307:Dose-Response Relationship, Radiation; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011879:Radiotherapy Dosage; D015996:Survival Rate
chemical_list: D007496:Iridium Radioisotopes