Pulmonary veno-occlusive disease in a HIV-infected intravenous drug abuser.
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. Its origin remains unknown but in some cases a viral aetiology has been suggested. Recently primary pulmonary hypertension has been increasingly observed in patients with human immunodeficiency virus (HIV) infection, but only one case of pulmonary veno-occlusive disease has so far been described. We report the case of a 27 year old male intravenous drug abuser with HIV infection and pulmonary hypertension. Open lung biopsy led to the diagnosis of pulmonary veno-occlusive disease. This second case of pulmonary veno-occlusive disease raises the question of a relationship between HIV infection and lesions involving the pulmonary veins. However, the pathogenesis of vascular changes remains to be elucidated.
Escamilla
R
R
Service de Pneumo-Allergologie, Toulouse, France.
Hermant
C
C
Berjaud
J
J
Mazerolles
C
C
Daussy
X
X
D000328:Adult; D001706:Biopsy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008297:Male; D011667:Pulmonary Veins / Q000473:pathology; D011668:Pulmonary Veno-Occlusive Disease / Q000209:etiology* / Q000473:pathology; D015819:Substance Abuse, Intravenous / Q000150:complications*