title: Coexistence of cerebral venous sinus and internal carotid artery thrombosis associated with exogenous sex hormones. A case report.
abstract: A forty-six year-old premenopausal woman developed headache, nausea and vomiting, left hemiparesis and seizure two days after parenteral use of progesterone and estradiol. Diabetes mellitus (DM) was found during admission. Computed tomography showed a hemorrhagic infarct in the right frontal lobe and increased density in the superior sagittal sinus (SSS). Left carotid angiography found occlusion of the left internal carotid artery (ICA). Right carotid angiograms failed to show the SSS and inferior sagittal sinus, suggestive of venous sinus thrombosis. Coexistence of the cerebral artery and the venous sinus occlusion has been described infrequently. In this case, the authors postulate that the use of estradiol and progesterone and the underlying DM increased vascular thrombogenicity, which provided a common denominator for thrombosis of both the ICA and the venous sinus.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Ryu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chien
mesh_terms: D002341:Carotid Artery Thrombosis / Q000139:chemically induced*; D002343:Carotid Artery, Internal; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D002544:Cerebral Infarction / Q000139:chemically induced; D048909:Diabetes Complications; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000209:etiology; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D017697:Premenopause; D011374:Progesterone / Q000009:adverse effects*; D012851:Sinus Thrombosis, Intracranial / Q000139:chemically induced*; D014839:Vomiting / Q000209:etiology
chemical_list: D011374:Progesterone