Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis.
The association of viral infections with autoimmune central nervous system (CNS) diseases such as post-infectious encephalomyelitis and possibly multiple sclerosis (MS) prompted the investigation to understand how virus infection could modulate autoimmune responses. Recombinant vaccinia viruses encoding an encephalitogenic portion of myelin basic protein (MBP) were evaluated in an animal model for human demyelinating disease, experimental allergic encephalomyelitis (EAE). We have determined that mice vaccinated with recombinant viruses encoding an encephalitogenic region of MBP were protected from EAE. In vivo depletion of CD8+ T cells did not abrogate this protection, suggesting lack of regulation by this cell type. These studies demonstrate that virus infection may be a means to modulated immune responsiveness to CNS disease.
Barnett
L A
LA
Department of Neurology, University of Utah, Salt Lake City 84132, USA.
Whitton
J L
JL
Wang
L Y
LY
Fujinami
R S
RS
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control*; D016827:CD8 Antigens / Q000187:drug effects; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000517:prevention & control*; D000939:Epitopes; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000494:pharmacology / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology*; D011995:Recombination, Genetic; D013045:Species Specificity; D013601:T-Lymphocytes / Q000187:drug effects; D014611:Vaccination; D014616:Vaccinia virus / Q000235:genetics*
D016827:CD8 Antigens; D000939:Epitopes; D004676:Myelin Basic Protein; D010446:Peptide Fragments