Oncogenes and antioncogenes in lung tumorigenesis.
The role of oncogenes and antioncogenes in lung tumorigenesis is discussed in this review, with particular emphasis on their prognostic significance. Mutations in the ras family of oncogenes, overexpression of the myc and neu families of oncogenes, and mutations of p53, the recessive tumor suppressor gene, occur with differing frequencies in small cell lung cancer and non-small cell lung cancer, and are usually associated with a poor prognosis. Loss of heterozygosity, notably on chromosomes 3p, 5q, 9p, 13q, and 17p, is a common feature in lung carcinomas and its importance is also discussed.
Giaccone
G
G
Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000235:genetics; D002454:Cell Differentiation; D002872:Chromosome Deletion; D004273:DNA, Neoplasm; D016147:Genes, Tumor Suppressor / Q000235:genetics* / Q000502:physiology; D016158:Genes, p53; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics* / Q000502:physiology; D011379:Prognosis
D004273:DNA, Neoplasm