title: Translocation (Y;1)(q12;q12) in hematologic malignancies. Report on two new cases, FISH characterization, and review of the literature.
abstract: Translocation (Y;1)(q12;q12) is a rare cytogenetic anomaly occurring in hematologic disorders thought to affect stem cells. We report here on two new cases, one end-stage myelofibrosis and one chronic myelomonocytic leukemia. The translocation breakpoints were assessed by conventional cytogenetic techniques in both cases and by FISH in the second case. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.
authors.affiliation: Center for Human Genetics, University of Louvain, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Michaux
authors.forename: I
authors.initials: I
authors.lastname: Wlodarska
authors.forename: E R
authors.initials: ER
authors.lastname: Vellosa
authors.forename: G
authors.initials: G
authors.lastname: Verhoef
authors.forename: A
authors.initials: A
authors.lastname: Van Orshoven
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: J M
authors.initials: JM
authors.lastname: Scheiff
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000293:Adolescent; D000368:Aged; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D055728:Primary Myelofibrosis / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy; D014998:Y Chromosome