Protective effect of Tadenan on bladder function secondary to partial outlet obstruction.
OBJECTIVE
Tadenan (DEBAT, Paris, France) is a pharmaceutical agent used in the treatment of benign prostatic hyperplasia (BPH). The specific aim of this study was to determine if pretreatment of rabbits with Tadenan reduced either the hypertrophic response of the bladder to partial outlet obstruction or the accompanying contractile dysfunction.


METHODS
Twenty-five male New Zealand rabbits (3 to 5 kg.) were separated into 5 groups of 5 rabbits each. Each rabbit in groups 1,2, and 3 received Tadenan orally at 1, 10 and 100 mg./kg./day for 3 weeks. Group 4 received vehicle only (peanut oil); Group 5 were controls. The bladders were evaluated (in vitro studies) after 2 weeks of obstruction.


RESULTS
1) Tadenan did not reduce the effect of partial outlet obstruction on bladder mass. 2) Tadenan pretreatment resulted in a significant protective effect on the contractile responses to field stimulation, bethanechol and KCl.


CONCLUSIONS
These results clearly demonstrate that Tadenan pretreatment protected the bladder from the contractile dysfunctions induced by partial outlet obstruction.
Levin
R M
RM
Division of Urology, University of Pennsylvania 19104, USA.
Riffaud
J P
JP
Bellamy
F
F
Rohrmann
D
D
Habib
M
M
Krasnopolsky
L
L
Zhao
Y
Y
Wein
A J
AJ
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D018723:Bethanechol / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology*; D001748:Urinary Bladder Neck Obstruction / Q000503:physiopathology*
D005233:Fatty Alcohols; D010936:Plant Extracts; C009375:Tadenan; D018723:Bethanechol; D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D004247:DNA