title: The prognostic importance of fibronectin and sialic acid levels in human pituitary adenomas.
abstract: In this study, fibronectin and sialic acid levels were determined in human pituitary adenomas. The mean fibronectin and sialic acid levels for human pituitary adenomas were found to be 31.64 +/- 15.82 microgram/mg protein and 21.90 +/- 9.82 microgram/mg protein, respectively, versus 6.30 +/- 2.96 microgram/mg protein and 9.88 +/- 2.81 microgram/mg protein for the normal brain tissues. Fibronectin and sialic acid levels were significantly higher (P < 0.001) in human pituitary adenomas than the normal brain tissues. In human infiltrative and non-infiltrative pituitary adenomas, the mean fibronectin and sialic acid levels were found to be 40.87 +/- 15.90 microgram/mg protein, 27.59 +/- 11.10 microgram/mg protein and 22.40 +/- 9.51 microgram/mg protein, 16.21 +/- 3.20 microgram/mg protein, respectively. Fibronectin and sialic acid levels were slightly elevated (P < 0.05) in human infiltrative pituitary adenomas compared with non-infiltrative adenomas.
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ozyurt
authors.forename: H
authors.initials: H
authors.lastname: Sönmez
authors.forename: S
authors.initials: S
authors.lastname: Süer
authors.forename: E
authors.initials: E
authors.lastname: Kökoğlu
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011379:Prognosis; D012016:Reference Values; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D005353:Fibronectins; D012794:Sialic Acids