Penetration of topical 0.3% ciprofloxacin into human aqueous humor.
OBJECTIVE
Investigation of the penetration of topical ciprofloxacin into aqueous humor.


METHODS
Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection.


RESULTS
Mean aqueous concentration was 0.83+/-0.48 microgram/ml in group A and 2.42+/-1.42 micrograms/ml in group B.


CONCLUSIONS
Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.
Kalayci
D
D
Department of Ophthalmology, Numune State Research and Training Hospital, Ankara, Turkey.
Basci
N
N
Akpek
E
E
Hasiripi
H
H
Bozkurt
A
A
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008875:Middle Aged; D009994:Osmolar Concentration; D011292:Premedication
D000890:Anti-Infective Agents; D002939:Ciprofloxacin