title: The role of sleep-disordered breathing in essential hypertension.
abstract: In recent years there have been numerous reports addressing the relationship between sleep-disordered breathing (SDB) and hypertension (HTN). This study investigated the relationship between SDB and BP after controlling for age, gross obesity, and notably, antihypertensive medications. Sixty-seven men and women between 30 and 60 years of age and between 0.90 to 1.5 times ideal body weight were studied. SDB was assessed over two nights of polysomnographic monitoring, and BP was measured over repeated visits to the hospital. The results indicate that respiratory disturbance index (RDI) independently predicts diastolic BP (DBP), accounting for 15% of the variance in DBP (p=0.02). In subjects with severe levels of SDB (RDI >30), RDI uniquely accounted for 36% of the variance in DBP (p=0.003). Interestingly, SDB was not independently related to systolic BP. The physiologic mechanisms responsible for these findings are currently being explored.
authors.affiliation: SDSU/UCSD Joint Doctoral Program in Clinical Psychology, University of California, San Diego, USA.
authors.forename: T V
authors.initials: TV
authors.lastname: Coy
authors.forename: J E
authors.initials: JE
authors.lastname: Dimsdale
authors.forename: S
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: J L
authors.initials: JL
authors.lastname: Clausen
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005544:Forecasting; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D017286:Polysomnography; D012044:Regression Analysis; D012119:Respiration; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents