[Change in lipid peroxidation depending on hormonal reactions during lengthy electric stimulation of the rabbit hypothalamic dorsomedial nucleus].
A model of chronic emotional stress (ES) induced by electrostimulation of the hypothalamic dorsomedial nucleus in 69 rabbits was used to examine the relationship of blood hormonal changes and lipid peroxidation (LPO) activity in blood and myocardial cells. The elevated concentrations of stress hormones at the initial stages of chronic ES (the first 2 series) caused LPO with high activities of antioxidative enzymes (AOEs). The subsequent stages of chronic ES (from 60 to 120 days) were associated with the decreased role of major stress hormones (adrenocorticotropic hormone, cortisol, catecholamines) and the increased significance of parathyroid hormone and active renin (angiotensin I). A significant direct correlation was found between the blood level of these hormones and the rate of LPO in the myocardium and blood. At the same time the activity of AOEs progressively decreased and all rabbits exhibited myocardial cell necrotic foci.
Nikolaev
V I
VI
Denisenko
N P
NP
Nikolaeva
N V
NV
D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D002116:Calcitonin / Q000097:blood; D002395:Catecholamines / Q000097:blood; D004302:Dorsomedial Hypothalamic Nucleus / Q000378:metabolism* / Q000502:physiology; D004558:Electric Stimulation; D015227:Lipid Peroxidation; D009206:Myocardium / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D011817:Rabbits; D013315:Stress, Psychological / Q000201:enzymology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D010281:Parathyroid Hormone; D013963:Thyroid Hormones; D002116:Calcitonin; D013482:Superoxide Dismutase