Impaired neutrophil chemotaxis after cardiac surgery.
Chemotaxis of circulating peripheral neutrophils was studied in 12 patients undergoing elective cardiac surgery. Tests of neutrophil chemotaxis were made preoperatively and 16-20 hours postoperatively, using a multipore filter assay. Statistically significant postoperative decrease was demonstrated in both stimulated and random neutrophil migration (p = 0.012 and p = 0.009, respectively). Although the peripheral neutrophil count showed a statistically significant postoperative increase (p = 0.001), the increase did not correlate to the decrease in neutrophil chemotaxis. Nor could correlation be demonstrated between the altered neutrophil chemotaxis and any per- or postoperative variables.
Jensen
R H
RH
Department of Anaesthesiology, Skejby Hospital, University of Aarhus, Denmark.
Storgaard
M
M
Vedelsdal
R
R
Obel
N
N
D000768:Anesthesia, General; D001021:Aortic Valve / Q000601:surgery; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D001026:Coronary Artery Bypass; D004198:Disease Susceptibility; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008851:Micropore Filters; D008943:Mitral Valve / Q000601:surgery; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000502:physiology*; D013530:Surgical Wound Infection / Q000209:etiology
D009240:N-Formylmethionine Leucyl-Phenylalanine