title: Collagen gel and membrane in guided tissue regeneration in periodontal fenestration defects in dogs.
abstract: The effect of a collagen gel matrix as a submembranous space-maintaining material was evaluated in guided tissue regeneration procedures. In 4 dogs, contralateral surgical circular fenestration defects, 5 mm in diameter, were produced at the midbuccal aspect of the alveolar bone in 8 maxillary canines. Removal of bone, PDL and cementum was complete. Experimental sites were filled with collagen gel and covered with collagen membranes; control sites were covered with collagen membranes and the underlying space was spontaneously filled with blood. Mucogingival flaps were repositioned. Histological and histomorphometric observations, 6 weeks post-surgery, indicated that defects covered by collagen membranes presented the most impressive regeneration with almost complete coverage of the denuded root by new cementum (98.4%) and new bone (63.2%). In the experimental defects, 83.5% coverage of new cementum with only 21.9% new bone regeneration was observed. These results suggest that collagen gel, interfered with healing by PDL and bone-derived cells in the submembranous space.
authors.affiliation: Section of Periodontology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Tal
authors.forename: S
authors.initials: S
authors.lastname: Pitaru
authors.forename: O
authors.initials: O
authors.lastname: Moses
authors.forename: A
authors.initials: A
authors.lastname: Kozlovsky
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology / Q000503:physiopathology; D000541:Alveolectomy; D000818:Animals; D001861:Bone Regeneration; D003094:Collagen / Q000627:therapeutic use*; D003481:Cuspid; D003739:Dental Cementum / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004285:Dogs; D005782:Gels; D005893:Gingivoplasty; D016557:Guided Tissue Regeneration, Periodontal; D008566:Membranes; D009061:Mouth Mucosa / Q000601:surgery; D010510:Periodontal Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010513:Periodontal Ligament / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012038:Regeneration; D013524:Surgical Flaps
chemical_list: D005782:Gels; D003094:Collagen