Radiobiology of ultrasoft X rays. V. Modification of cell inactivation by dimethyl sulfoxide.
The effects of the radioprotector dimethyl sulfoxide (DMSO) were investigated for carbon-K (0.28 keV) and aluminum-K (1.47 keV) X rays compared with 60Co gamma rays for inactivation of mouse C3H 10T1/2 cells. The protection factor for 2 M DMSO was found to be 2.8 for both of the ultrasoft X-ray energies, which is not significantly different from the protection factor of 2.6 found for gamma rays. The results indicate that the proportion of scavengeable lethal damage from gamma and X rays does not depend on the proportion of the total energy that is deposited by low-energy electrons of relatively high ionization density.
Raju
M R
MR
Los Alamos National Laboratory, New Mexico, 87545, USA.
Schillaci
M E
ME
Carpenter
S G
SG
Goodhead
D T
DT
Ward
J F
JF
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian; D005720:Gamma Rays; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014965:X-Rays
D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D004121:Dimethyl Sulfoxide