Sertraline does not alter the beta-adrenergic blocking activity of atenolol in healthy male volunteers.
A double-blind, placebo-controlled, randomized, crossover study was conducted to determine the effect of sertraline on the beta-adrenergic blocking activity of atenolol in 10 healthy male volunteers.


METHODS
To assess the existence of any possible pharmacodynamic interaction between sertraline and atenolol, the effect of sertraline and placebo on the dose of intravenous isoproterenol required to increase heart rate by 25 beats per minute (bpm; chronotropic dose25 [CD25]) and the change in heart rate during exercise in atenolol-treated subjects were determined.


RESULTS
The mean CD25 of isoproterenol was 2.00 micrograms after administration of placebo plus atenolol 50 mg and 2.03 micrograms after administration of sertralnie 100 micrograms plus atenolol 50 mg. The mean heart rate during exercise testing decreased by 29 bpm after sertraline plus atenolol administration and by 31 bpm after placebo plus atenolol administration. Analysis of variance indicated no statistically significant treatment or sequence effects. Only 1 subject experienced an adverse event--a mild headache after administration of sertraline plus atenolol. No clinically significant electrocardiograph changes were observed after sertraline or placebo administration.


CONCLUSIONS
The results of this study demonstrate that sertraline does not alter the beta-blocking activity of atenolol.
Ziegler
M G
MG
University of California Medical Center, San Diego, USA.
Wilner
K D
KD
D015057:1-Naphthylamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D004336:Drug Antagonism; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D006261:Headache / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010919:Placebos; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D020280:Sertraline; D013268:Stimulation, Chemical
D015057:1-Naphthylamine; D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D010919:Placebos; D011943:Receptors, Adrenergic, beta; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline