title: The effectiveness of sublingual progesterone administration during cryopreserved embryo transfer cycles: results of a matched follow-up study.
abstract: OBJECTIVE
  To compare cryopreserved ET pregnancy rates in subjects receiving either sublingual parenteral P.
  
  
  METHODS
  Matched follow-up study.
  
  
  METHODS
  University-based assisted reproduction program.
  
  
  METHODS
  Women undergoing cryopreserved ET between January 1993, and December 1994. Cases received a hormone replacement protocol containing oral E2 and sublingual P and controls received a hormone replacement protocol containing oral E2 and parenteral P. Cases and controls were matched one-to-one according to age, number of embryos transferred, embryo grade, and route of ET.
  
  
  METHODS
  Cryopreserved embryos were thawed and transferred in all patients in an identical manner independent of the route of P administration.
  
  
  METHODS
  Clinical and ongoing pregnancy rates.
  
  
  RESULTS
  Of 61 ET cycles performed in the sublingual P group, there were 16 clinical pregnancies (26.2%) and 12 ongoing pregnancies (19.7%). Of the 61 ET cycles in the parenteral P group, there were 14 clinical pregnancies (23.0%) and 11 ongoing pregnancies (18.0%). A chi 2 test revealed no significant differences in either clinical or ongoing pregnancy rates according to the route of P administration.
  
  
  CONCLUSIONS
  This data suggests that sublingual P administration is an effective alternative to parenteral P administration in preparing the endometrium for the implantation of cryopreserved embryos.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa School of Medicine, Iowa City, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Stovall
authors.forename: B J
authors.initials: BJ
authors.lastname: Van Voorhis
authors.forename: K L
authors.initials: KL
authors.lastname: Mattingly
authors.forename: A E
authors.initials: AE
authors.lastname: Sparks
authors.forename: F K
authors.initials: FK
authors.lastname: Chapler
authors.forename: C H
authors.initials: CH
authors.lastname: Syrop
mesh_terms: D000286:Administration, Sublingual; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
chemical_list: D011374:Progesterone