Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation.
Adenoviruses may cause severe infections in bone marrow transplant recipients. We report the case of a patient who developed fulminant hepatitis 5 months after bone marrow transplantation. Adenovirus type 2 was cultured from stool and blood samples. The patient died from liver failure. Histologic examination of post-mortem liver samples showed extensive necrosis with nuclear inclusions. Adenovirus was identified in liver cells by electron microscopy and immunohistochemical staining using a monoclonal anti-adenovirus antibody. No other pathogen was identified.
Bertheau
P
P
Laboratoire d'Anatomie Pathologique, Paris, France.
Parquet
N
N
Ferchal
F
F
Gluckman
E
E
Brocheriou
C
C
D000257:Adenoviridae Infections / Q000209:etiology / Q000473:pathology; D000260:Adenoviruses, Human / Q000145:classification / Q000302:isolation & purification*; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003106:Colon / Q000821:virology; D017809:Fatal Outcome; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000209:etiology / Q000473:pathology / Q000821:virology*; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008099:Liver / Q000473:pathology / Q000821:virology; D017563:Lung Diseases, Interstitial / Q000209:etiology; D009336:Necrosis; D014184:Transplantation, Homologous