Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.
Novelli
M R
MR
Cancer Genetics Laboratory, Imperial Cancer Research Fund (ICRF) Laboratories, London, UK.
Williamson
J A
JA
Tomlinson
I P
IP
Elia
G
G
Hodgson
S V
SV
Talbot
I C
IC
Bodmer
W F
WF
Wright
N A
NA
D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002999:Clone Cells; D003106:Colon / Q000473:pathology*; D015342:DNA Probes; D005838:Genotype; D006801:Humans; D007082:Ileum / Q000473:pathology; D017403:In Situ Hybridization; D017404:In Situ Hybridization, Fluorescence; D007413:Intestinal Mucosa / Q000473:pathology*; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D010641:Phenotype; D014998:Y Chromosome
D015342:DNA Probes