Fluconazole treatment of Candida albicans infection in mice: does in vitro susceptibility predict in vivo response?
A series of fluconazole-susceptible and-fluconazole resistant Candida albicans fungal isolates were used to infect mice intravenously. Mice were treated with varying doses of fluconazole beginning one day after infection. For all of the 6 fluconazole-susceptible isolates, fluconazole was highly effective at <0.25 mg/kg of body weight twice daily. By contrast, fluconazole was less effective in at least 6 of 10 fluconazole-resistant isolates and was ineffective at > or = 40 mg/kg twice daily in 4 fluconazole-resistant isolates. Although the correlation is not precise, in vitro susceptibility testing of C. albicans can predict in vivo response to fluconazole.
Graybill
J R
JR
Division of Infectious Diseases (111F), Audie Murphy VA Hospital, San Antonio, TX 78284, USA.
Najvar
L K
LK
Holmberg
J D
JD
Correa
A
A
Luther
M F
MF
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy*; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D015725:Fluconazole