title: Atherosclerotic arterial remodeling in the superficial femoral artery. Individual variation in local compensatory enlargement response.
abstract: BACKGROUND
  In previous studies on atherosclerotic arterial remodeling, compensatory enlargement of the artery in response to plaque accumulation was inferred from pooled data based on one cross section per artery. We assessed local arterial remodeling individually by analyzing 45 artery segments at 0.5-cm intervals over a length of 10 to 15 cm.
  
  
  RESULTS
  Twenty patients were studied by 30-MHz intravascular ultrasound (IVUS) before balloon angioplasty of the superficial femoral artery (370 cross sections), and 25 femoral artery segments were studied postmortem (551 cross sections). In each cross section, the area surrounded by the internal elastic lamina (IEL area) and the plaque area were measured. The IEL area was larger in the cross section with the largest plaque area than in the cross section with the smallest plaque area (32.5+/-13.0 and 32.0+/-11.5 mm2 versus 28.9+/-9.7 [P=NS] and 26.7+/-10.1 [P<.05] mm2 for IVUS and histology, respectively [mean+/-SD]). A significant positive correlation was found between plaque area and IEL area for the pooled data (r=.61 and r=.47 and slope=1.07 and 0.90 for IVUS and histology, respectively; both P<.001). In 12 of 20 and 16 of 25 individual arterial segments, however, no significant correlation was observed between plaque area and IEL area for IVUS and histology, respectively. A large variation was found in the correlation of the regression of plaque to IEL area (IVUS, r=-.40 to .89; histology, r=-.13 to .91) and slope (IVUS, -0.28 to 1.29; histology, -0.18 to 1.32).
  
  
  CONCLUSIONS
  In the majority of atherosclerotic femoral arteries, significant compensatory enlargement could not be determined. It is inferred that arterial remodeling in response to plaque formation may vary among individuals.
authors.affiliation: Heart Lung Institute, Utrecht University Hospital, Utrecht, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Pasterkamp
authors.forename: C
authors.initials: C
authors.lastname: Borst
authors.forename: M J
authors.initials: MJ
authors.lastname: Post
authors.forename: W P
authors.initials: WP
authors.lastname: Mali
authors.forename: P J
authors.initials: PJ
authors.lastname: Wensing
authors.forename: E J
authors.initials: EJ
authors.lastname: Gussenhoven
authors.forename: B
authors.initials: B
authors.lastname: Hillen
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014463:Ultrasonography