Translocation (9;11;22)(p22;q23;q11). A new type of complex variant translocation of t(9;11)(p22;q23) with MLL rearrangement.
We describe a patient with acute monocytic leukemia (M5a, FAB classification) associated with a new type of variant translocation (9;11). Southern blot analysis showed the rearrangement of the MLL (ALL-1/HRX) gene at 11q23. Fluorescence in situ hybridization (FISH) with painting probes of chromosomes 9, 11, and 22 revealed the translocation as t(9;11;22) (p22;q23;q11). This is more evidence that the production of chimeric mRNA following the translocation of the LTG9 (MLLT3/AF9) gene at 9p22 to 11q is a critical event in this leukemia subtype.
Takahashi
N
N
Third Department of Internal Medicine, Akita University School of Medicine, Japan.
Miura
I
I
Ohshima
A
A
Nimura
T
T
Hashimoto
K
K
Hatano
Y
Y
Utsumi
S
S
Kume
M
M
Saito
K
K
Kobayashi
Y
Y
Saito
M
M
Seto
M
M
Ueda
R
R
Miura
A B
AB
D000328:Adult; D015139:Blotting, Southern; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic