title: Effects of age, socioeconomic status, and menstrual cycle on pulmonary response to ozone.
abstract: The purpose of this study was to investigate the effects of age, socioeconomic status, and menstrual cycle phase on the pulmonary response to ozone exposure. Three hundred seventy-two healthy white and black young adults, between the ages of 18 and 35 y, were exposed only once to 0.0, 0.12, 0.18, 0.24, 0.30, or 0.40 ppm ozone for 2.3 h. Prior to and after exposure, pulmonary function tests were obtained. Prior to exposure, each subject completed a personal and family-history questionnaire. The responses to this questionnaire were used to investigate age, socioeconomic status, and menstrual cycle phase effects on pulmonary responsiveness to ozone. We concluded that the ages of subjects, within the age range studied, had an effect on responsiveness (i.e., decrements in forced expiratory volume in 1 s decreased as the subjects' ages decreased). Socioeconomic status, as reflected by education of fathers, also appeared to affect forced expiratory volume in 1-s responsiveness to ozone, with the middle socioeconomic group being the most responsive. The phase of menstrual cycle did not have an impact on individual responsiveness to ozone.
authors.affiliation: Human Studies Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
authors.forename: E
authors.initials: E
authors.lastname: Seal
authors.forename: W F
authors.initials: WF
authors.lastname: McDonnell
authors.forename: D E
authors.initials: DE
authors.lastname: House
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D001273:Atmosphere Exposure Chambers; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008597:Menstrual Cycle / Q000502:physiology*; D010126:Ozone / Q000008:administration & dosage / Q000494:pharmacology*; D012959:Socioeconomic Factors
chemical_list: D010126:Ozone