title: Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors.
abstract: Rotavirus can cause severe gastrointestinal disease, especially in infants and young children, and is particularly prevalent in Third-World countries. Therefore, the development of potential inhibitors of this virus is of great interest. The present study describes the synthesis and in vitro biological evaluation of a number of N-acetylneuraminic acid-based compounds as potential rotavirus inhibitors. Our data suggests that it is indeed possible to inhibit adhesion of the virus, and hence in vitro replication, with carbohydrate-based molecules, although this inhibition does appear to be strain dependent.
authors.affiliation: Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kiefel
authors.forename: B
authors.initials: B
authors.lastname: Beisner
authors.forename: S
authors.initials: S
authors.lastname: Bennett
authors.forename: I D
authors.initials: ID
authors.lastname: Holmes
authors.forename: M
authors.initials: M
authors.lastname: von Itzstein
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D011817:Rabbits; D012401:Rotavirus / Q000187:drug effects*; D012794:Sialic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D012794:Sialic Acids; D013865:Thioglycosides