(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.
Wermuth
C G
CG
Centre de Neurochimie du CNRS, Strasbourg, France.
Mann
A
A
Schoenfelder
A
A
Wright
R A
RA
Johnson
B G
BG
Burnett
J P
JP
Mayne
N G
NG
Schoepp
D D
DD
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000600:Amino Acids, Dicarboxylic / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007202:Indicators and Reagents; D007295:Inositol Phosphates / Q000378:metabolism; D007700:Kinetics; D009498:Neurotoxins / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*
C098594:2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid; D000600:Amino Acids, Dicarboxylic; D007202:Indicators and Reagents; D007295:Inositol Phosphates; D009498:Neurotoxins; D010716:Phosphatidylinositols; D018094:Receptors, Metabotropic Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D018698:Glutamic Acid; D000262:Adenylyl Cyclases