Studies on cochleamycins, novel antitumor antibiotics. II. Physico-chemical properties and structure determination.
The structure of cochleamycins A, A2, B and B2 (Fig. 1), novel antitumor antibiotics, were elucidated by NMR spectral analysis. Cochleamycins were found to possess novel carbocyclic skeletons.
Shindo
K
K
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Iijima
H
H
Kawai
H
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003517:Cyclopentanes / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013053:Spectrophotometry
D000903:Antibiotics, Antineoplastic; D002247:Carbon Isotopes; D003517:Cyclopentanes; D007783:Lactones; C099300:cochleamycin A; C099301:cochleamycin A2; C099302:cochleamycin B; C099303:cochleamycin B2; D006859:Hydrogen