"Sunbath polyneuritis": subacute axonal neuropathy in perazine-treated patients after intense sun exposure.
This article aims at drawing attention to the peculiar association of intense exposure to sunlight and subacute development of sensory neuropathy which was seen in 7 psychiatric patients treated with the phenothiazine derivative, perazine. Three patients additionally developed bilateral VII nerve palsy. Symptoms followed a monophasic course with almost complete remission. Routine neurophysiology suggested axonal neuropathy confirmed by sural nerve biopsy in 1 patient. A toxic origin of neuropathy is supposed, possibly induced by phenothiazine photoproducts, which may cause cell damage via lipid peroxidation.
Roelcke
U
U
University Department of Neurology, Heidelberg, Germany.
Hornstein
C
C
Hund
E
E
Schmitt
H P
HP
Siess
R
R
Kaltenmaier
M
M
Fassler
J
J
Meinck
H M
HM
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005158:Facial Paralysis / Q000139:chemically induced / Q000209:etiology; D005260:Female; D006370:Heliotherapy; D006801:Humans; D008297:Male; D009431:Neural Conduction; D009443:Neuritis / Q000139:chemically induced* / Q000209:etiology* / Q000473:pathology; D010464:Perazine / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries; D012559:Schizophrenia / Q000188:drug therapy; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology
D010464:Perazine