Animal caries models for evaluating fluoride dentifrices.
To determine the ability of animal caries models to evaluate the cariostatic potential of fluoride dentifrices, we examined four different coronal caries models. These currently used rat caries models were: Francis' hypomineralized area model, Gaffar's CARA rat model, the Connecticut model, and the Indiana model. Available data indicated that all of these models were capable of detecting significant cariostatic benefits from clinically proven fluoride dentifrices. For the most part, these animal models were also able to demonstrate a response to increasing concentrations of fluoride, particularly if the fluoride was provided in an ionic rather than a complexed form. Data were also presented which indicated the potential for animal caries models to be used to predict the clinical benefits of non-fluoride systems as well as the utility of fluoride systems for the prevention of root-surface caries. It is concluded that animal caries models play a significant role in the development and evaluation of fluoride and other systems for the clinical prevention of dental caries.
Stookey
G K
GK
Indiana University School of Dentistry, Oral Health Research Institute, Indianapolis 46202-2876, USA.
Warrick
J M
JM
Miller
L L
LL
Greene
A L
AL
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use*; D006224:Cricetinae; D003731:Dental Caries / Q000188:drug therapy*; D018865:Dental Research / Q000379:methods; D003802:Dentifrices / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D010710:Phosphates / Q000627:therapeutic use; D051381:Rats; D017213:Root Caries / Q000628:therapy; D012969:Sodium Fluoride / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods
D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D003802:Dentifrices; D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides