title: Needle aspiration techniques in preoperative selection of patients with thyroid nodules: a long-term study.
abstract: OBJECTIVE
  Long-term evaluation of the combination of two needle aspiration techniques (NAT) (fine-needle aspiration [FNA] and aspiration needle biopsy [ANB]) in performing an efficient preoperative selection of palpable thyroid nodules.
  
  
  METHODS
  Eight years of extensive use of surgery for the detection of thyroid cancer was compared with 12 years of preoperative selection of by NAT.
  
  
  RESULTS
  A total of 1,140 operations were performed from 1972 to 1979, and 35 malignant nodules were discovered (3.1%). Five thousand four hundred three patients were examined by NAT from 1980 to 1992; 483 (9%) underwent surgery and 158 malignant nodules were excised. The number of malignant nodules identified by NAT was 166 (eight were not excised) (3.1% of the total population examined). The principal clinical and pathologic features were similar in both groups. ANB yielded a definite benign diagnosis in 88 patients with inadequate FNA findings, it correctly identified four malignant nodules diagnosed as benign by FNA, it showed a macrofollicular component in 115 nodules diagnosed by FNA as microfollicular nodules, and it significantly changed the predictive value of 79 suspicions FNA diagnoses.
  
  
  CONCLUSIONS
  Introduction of NAT reduced the number of operations for palpable thyroid nodules from 143 to 40 per year and increased from four to 13 the number of malignant nodules excised without any change in the overall incidence of malignant nodules. The combination of ANB to FNA significantly contributed to the high and efficient preoperative patient selection, principally by reducing the number of indeterminate or suspicious, as well as false-negative, preoperative FNA diagnoses.
authors.affiliation: Department of Internal Medicine, University of Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carpi
authors.forename: E
authors.initials: E
authors.lastname: Ferrari
authors.forename: M G
authors.initials: MG
authors.lastname: Toni
authors.forename: A
authors.initials: A
authors.lastname: Sagripanti
authors.forename: A
authors.initials: A
authors.lastname: Nicolini
authors.forename: G
authors.initials: G
authors.lastname: Di Coscio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012680:Sensitivity and Specificity; D016606:Thyroid Nodule / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery