title: Use of immobilized synthetic peptides for the identification of contact sites between human interleukin-6 and its receptor.
abstract: Synthetic peptides immobilized on cellulose membranes proved to be a powerful tool for the identification of sites in the cytokine IL-6 involved in receptor binding. Similarly, a region in the extracellular part of the IL-6 receptor which is important for interaction with its ligand was identified.
authors.affiliation: Institut für Biochemie der RWTH Aachen, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Weiergräber
authors.forename: J
authors.initials: J
authors.lastname: Schneider-Mergener
authors.forename: J
authors.initials: J
authors.lastname: Grötzinger
authors.forename: A
authors.initials: A
authors.lastname: Wollmer
authors.forename: A
authors.initials: A
authors.lastname: Küster
authors.forename: M
authors.initials: M
authors.lastname: Exner
authors.forename: P C
authors.initials: PC
authors.lastname: Heinrich
mesh_terms: D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D001665:Binding Sites; D003001:Cloning, Molecular; D004926:Escherichia coli; D006801:Humans; D015850:Interleukin-6 / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D008961:Models, Structural; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary; D018123:Receptors, Interleukin / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D019947:Receptors, Interleukin-6; D011994:Recombinant Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D015850:Interleukin-6; D010455:Peptides; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6; D011994:Recombinant Proteins