Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes.
DBA/2 mice treated with anti-Mac1 monoclonal antibody (MAb) failed to develop encephalomyocarditis virus (EMCV)-induced diabetes and myocarditis. Virus concentrations and the number of viral RNA-positive cells in the pancreas and heart were significantly reduced in mice treated with anti-Mac1 MAb. Mac1-positive macrophages seem to be involved in EMCV-induced disease and to affect the replication of EMCV in target organs.
Hirasawa
K
K
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Tsutsui
S
S
Takeda
M
M
Mizutani
M
M
Itagaki
S
S
Doi
K
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D018188:Cardiovirus Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D002452:Cell Count; D002460:Cell Line; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D004686:Encephalomyocarditis virus / Q000276:immunology*; D006321:Heart / Q000821:virology; D016177:Macrophage-1 Antigen / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009205:Myocarditis / Q000276:immunology* / Q000473:pathology / Q000821:virology; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D010179:Pancreas / Q000276:immunology / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000378:metabolism; D051381:Rats; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D016177:Macrophage-1 Antigen; D012367:RNA, Viral