title: [False-positive ELISA reactions for the hepatitis C virus and the human immunodeficiency virus after anti-influenzal vaccination].
abstract: Possible appearance of ELISA false-positive results for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) after vaccination against influenza was studied on 402 volunteers before, and 30 and 90 days after that. Our results prove that influenza vaccine can sometimes induce false-positive ELISA for HCV, but not for HIV. Their frequency is relatively small--0.96% in 10-20-years-old group and 3.1% in over 60 years age, while in 3-6 years age there were not registered this kind of reactions. The surveillance of individual ELISA-positive cases over time proves that cross-reacting antibodies HCV raised after vaccination against influenza are present only in second sera, that means 30 days after vaccination, but these antibodies disappeared 90 days later.
authors.affiliation: Institutul Cantacuzino.
authors.forename: E
authors.initials: E
authors.lastname: Ioniţă
authors.forename: E
authors.initials: E
authors.lastname: Lupulescu
authors.forename: V
authors.initials: V
authors.lastname: Alexandrescu
authors.forename: C
authors.initials: C
authors.lastname: Chiriţă
authors.forename: M
authors.initials: M
authors.lastname: Bălteanu
authors.forename: A E
authors.initials: AE
authors.lastname: Neguţ
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods / Q000706:statistics & numerical data; D005189:False Positive Reactions; D015483:HIV Antibodies / Q000097:blood*; D016174:Hepacivirus / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D008875:Middle Aged; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated