title: The pharmacokinetics of phenytoin in gingival crevicular fluid and plasma in relation to gingival overgrowth.
abstract: The aim of this study was to determine whether phenytoin (PHT) could be detected in gingival crevicular fluid (GCF), and to relate its concentration to both plasma level and degree of gingival overgrowth. 23 patients medicated with phenytoin for at least 6 months were clinically examined for signs of periodontal disease and gingival overgrowth. 12 patients out of these demonstrated clinically significant overgrowth and their plaque scores and gingival inflammation were greater than for the non-overgrowth group (p < 0.001). Phenytoin concentrations were determined by high performance liquid chromatography, and was detected in GCF. There was a significant correlation between the GCF and plasma phenytoin concentrations (p < 0.05), but it was not related to the extent of gingival overgrowth. Inflammation increased the GCF volume, but was not a determinant of GCF phenytoin concentration. It is concluded that effusion of phenytoin into GCF is regulated by the plasma levels of the drug, but its concentration in GCF is not related to the incidence of gingival overgrowth.
authors.affiliation: Department of Restorative Dentistry, University of Newcastle upon Tyne, UK.
authors.forename: W S
authors.initials: WS
authors.lastname: McLaughlin
authors.forename: D E
authors.initials: DE
authors.lastname: Ball
authors.forename: R A
authors.initials: RA
authors.lastname: Seymour
authors.forename: F
authors.initials: F
authors.lastname: Kamali
authors.forename: K
authors.initials: K
authors.lastname: White
mesh_terms: D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000378:metabolism*; D005885:Gingival Hyperplasia / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D005891:Gingivitis / Q000097:blood / Q000139:chemically induced / Q000378:metabolism; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000097:blood / Q000139:chemically induced / Q000378:metabolism; D010512:Periodontal Index; D010672:Phenytoin / Q000009:adverse effects / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D010672:Phenytoin