title: Continuous assessment of relative cerebral blood volume in transient ischemia using steady state susceptibility-contrast MRI.
abstract: The utility of a noninvasive steady state susceptibility-contrast MRI technique for continuous measurement of relative cerebral blood volume (rCBV) during global transient ischemia and subsequent hyperemia in a feline ischemia model is demonstrated. The measurements were obtained during a 10-min period of occlusion and 1-h period of reperfusion. Maximal hyperemic responses in gray matter, basal ganglia, and white matter (observed at 7,7, and 5 min, respectively) were 1.9 +/- 0.5, 1.8 +/- 0.3, and 1.7 +/- 0.6 times greater than baseline CBV (mean +/- SEM). Thirty to forty minutes after onset of reperfusion, CBV returned to normal. Thereafter, it decreased below baseline, nearing the control level by 1 h after onset of reperfusion. Steady state susceptibility-contrast MRI permits continuous, in vivo mapping of alterations in CBV.
authors.affiliation: Massachusetts General Hospital, Department of Radiology--C.I.P.R., Charlestown 02129, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Hamberg
authors.forename: P
authors.initials: P
authors.lastname: Boccalini
authors.forename: G
authors.initials: G
authors.lastname: Stranjalis
authors.forename: G J
authors.initials: GJ
authors.lastname: Hunter
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.forename: E
authors.initials: E
authors.lastname: Halpern
authors.forename: R M
authors.initials: RM
authors.lastname: Weisskoff
authors.forename: M A
authors.initials: MA
authors.lastname: Moskowitz
authors.forename: B R
authors.initials: BR
authors.lastname: Rosen
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002415:Cats; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D007501:Iron; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D058185:Magnetite Nanoparticles; D010087:Oxides
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide