Sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70.
The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.
Yumita
N
N
School of Pharmaceutical Sciences, Toho University, Chiba.
Sasaki
K
K
Umemura
S
S
Nishigaki
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001415:Back; D002277:Carcinoma / Q000188:drug therapy*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D005708:Gallium / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014464:Ultrasonic Therapy
D000970:Antineoplastic Agents; D011166:Porphyrins; C081908:ATX 70; D005708:Gallium