New biodegradable oligoesters for pharmaceutical application.
Tartaric acid, malic acid, and glyceric acid were copolycondensed with glycolic acid at various molar ratios in feed to quickly synthesize biodegradable oligoesters. They were likely to have a moderately cross-linked structure with relatively low molecular weights and hydrophilic groups on the chains. In addition to macroscopic gels which were insoluble in any solvents, we could obtain the oligoesters which were insoluble in water but soluble in N,N-dimethylformamide. The degradation rate of the oligoesters was higher than that of lactic acid (LA) oligomers having molecular weights of a few thousands. On the contrary, their glass transition and flow temperatures were much higher than those of LA oligomers, indicating that their handling during the preparation of drug delivery dosage forms was much improved. The formulation of microspheres containing drugs from the oligoesters revealed that they were useful as biodegradable matrices having high degradation rates.
Wada
R
R
Research Center for Biomedical Engineering, Kyoto University, Japan.
Hyon
S H
SH
Ikada
Y
Y
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004317:Doxorubicin; D005472:Fluorouracil; D005782:Gels; D005988:Glyceric Acids; D008293:Malates; D008863:Microspheres; D015394:Molecular Structure; D011108:Polymers; D012995:Solubility; D012997:Solvents; D013644:Tartrates; D013816:Thermodynamics
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005782:Gels; D005988:Glyceric Acids; D008293:Malates; D011108:Polymers; D012997:Solvents; D013644:Tartrates; C042971:glyceric acid; D004317:Doxorubicin; C030298:malic acid; D005472:Fluorouracil; C029768:tartaric acid