[Residual risks of viral transmission by transfusions and projected yields of additional screening tests. Retrovirus Epidemiology Donors Study (REDS)].
The residual risk of virus transmission associated with infectious seroconversion, window period donations can be estimated by combining the incidence rate of infection among repeat donors with the duration of the pre-seroconversion window period, thus deriving the rate of window phase donations missed by current screening. The residual risks are for HIV 2.0/10(6); HTLV 1.6/10(6); HCV 9.7/10(6); HBV 15.0/10(6). Similarly the net yield and incremental reduction in risk of routine implementation of new tests can be estimated, demonstrating the potential interest of nucleic acid detection.
Busch
M P
MP
Irwin Memorial Blood Centers, San Francisco, California 94118, USA.
D000914:Antibodies, Viral / Q000097:blood*; D001782:Blood Donors; D006678:HIV / Q000502:physiology; D016174:Hepacivirus / Q000502:physiology; D006515:Hepatitis B virus / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000502:physiology; D015367:Human T-lymphotropic virus 2 / Q000502:physiology; D006801:Humans; D015994:Incidence; D008403:Mass Screening; D012189:Retrospective Studies; D018570:Risk Assessment; D065227:Transfusion Reaction; D014777:Virus Diseases / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*
D000914:Antibodies, Viral