title: L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers.
abstract: In order to assess associations between the genetic polymorphism of L-myc and glutathione S-transferase M1 (GST M1) and the risk of hepatocellular carcinoma (HCC), a total of 46 surgically treated HCC patients who were seropositive in hepatitis B surface antigen (HBsAg) and 88 HBs-Ag positive controls were recruited for this study. L-myc and GST M1 genetic polymorphism was examined using a polymerase chain reaction-based restriction fragment length polymorphism assay on DNA extracted from liver and peripheral blood samples. There was no significant difference in GST M1 genotypes between HCC patients and matched controls. A gene dosage trend of association with HCC risk was observed for L-myc genotype. The dose-response relationship remained statistically significant in the multiple logistic regression analysis.
authors.affiliation: Department of Public Health, Chang Gung College of Medicine and Technology, Tao-Yuan, Taiwan, ROC.
authors.forename: L L
authors.initials: LL
authors.lastname: Hsieh
authors.forename: R C
authors.initials: RC
authors.lastname: Huang
authors.forename: M W
authors.initials: MW
authors.lastname: Yu
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
authors.forename: Y F
authors.initials: YF
authors.lastname: Liaw
mesh_terms: D000367:Age Factors; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000235:genetics; D002353:Carrier State; D016022:Case-Control Studies; D002908:Chronic Disease; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D016259:Genes, myc; D005982:Glutathione Transferase / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D017931:DNA Primers; D005982:Glutathione Transferase