Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice.
Mice from various inbred strains consume alcoholic beverages at highly reproducible and strain-specific levels. While most mice consume alcohol in moderate amounts, C57BL/6J animals exhibit sustained oral ingestion of high levels of alcohol in the presence of competing water and food. We now report a genetic investigation of this phenotype as one potential model for alcoholism. An intercross-backcross breeding protocol was used to identify two recessive alcohol preference quantitative trait loci (QTLs) that are both sex-restricted in expression. A comparison of our results with those of an earlier morphine preference study argues against the hypothesis of a single unified phenotype defined by a preference for all euphoria-producing drugs.
Melo
J A
JA
Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
Shendure
J
J
Pociask
K
K
Silver
L M
LM
D000428:Alcohol Drinking / Q000235:genetics*; D000437:Alcoholism / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005260:Female; D005819:Genetic Markers; D005828:Genetics, Population; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008811:Mice, Inbred DBA; D010641:Phenotype; D012044:Regression Analysis; D015203:Reproducibility of Results
D005819:Genetic Markers