title: Polycondensed nitrogen heterocycles. Part 27. Indolo[3,2-c]cinnoline. Synthesis and antileukemic activity.
abstract: Indolo[3,2-c]cinnolines of type 5, variously substituted either in the indole and in the cinnoline moieties, were prepared in good overall yields, by intramolecular cyclization of indolo derivatives 4. Compounds 5a-d showed a good cytotoxic activity against FLC and K562 leukemic cell lines, both sensitive and multi-drug resistant.
authors.affiliation: Istituto Farmacochimico, Università degli Studi, Palermo.
authors.forename: G
authors.initials: G
authors.lastname: Cirrincione
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: S
authors.initials: S
authors.lastname: Grimaudo
authors.forename: G
authors.initials: G
authors.lastname: Dattolo
authors.forename: E
authors.initials: E
authors.lastname: Aiello
authors.forename: P
authors.initials: P
authors.lastname: Barraja
authors.forename: F
authors.initials: F
authors.lastname: Mingoia
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds