In vivo He-3 MR images of guinea pig lungs.
The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.
Black
R D
RD
Center for in Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA.
Middleton
H L
HL
Cates
G D
GD
Cofer
G P
GP
Driehuys
B
B
Happer
W
W
Hedlund
L W
LW
Johnson
G A
GA
Shattuck
M D
MD
Swartz
J C
JC
D000818:Animals; D006168:Guinea Pigs; D006371:Helium; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D011868:Radioisotopes
D011868:Radioisotopes; D006371:Helium