Selenium deficiency and miscarriage: a possible link?
OBJECTIVE
To investigate a possible relationship between a deficiency in serum selenium concentration and first trimester miscarriage.


METHODS
An observational study.


METHODS
A teaching hospital in South Wales.


METHODS
Serum selenium, albumin and total protein concentration were measured in 40 women admitted with first trimester nonrecurrent miscarriage. The results were compared with an equal number of age-matched nonpregnant healthy volunteers, and also from 40 pregnant women attending the antenatal clinic for booking in the first trimester.


RESULTS
A reduction in serum selenium normally occurs in the first trimester of pregnancies that progress to term. However, a further statistically highly significant decrease in serum selenium was observed in those women who miscarried.


CONCLUSIONS
Further studies are required to assess the potential benefits of selenium supplements.
Barrington
J W
JW
Department of Obstetrics and Gynaecology, Llandough Hospital, Penarth, United Kingdom.
Lindsay
P
P
James
D
D
Smith
S
S
Roberts
A
A
D000022:Abortion, Spontaneous / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D012643:Selenium / Q000172:deficiency*; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D012643:Selenium