title: Temporal link between plasma thyrotropin levels and electroencephalographic activity in man.
abstract: Plasma thyrotropin (TSH) levels have been previously shown to be associated with the internal sleep structure determined by conventional scoring of sleep stages. This temporal relationship was re-evaluated using spectral analysis of the sleep electroencephalogram (EEG). Eight healthy male subjects underwent two randomized night studies after having received either placebo or 5 mg ritanserin, a selective 5-HT2 receptor antagonist known to increase slow-wave sleep. Delta relative power and TSH levels, determined at 10 min intervals, were found to be inversely related with an average cross-correlation coefficient highly significant (P < 0.0001) in both experimental conditions. Alpha slow-wave index, an estimator of awakenings, and TSH pulses exhibited a significant temporal association in both conditions. These results demonstrate that TSH fluctuations are linked to the sleep EEG activity in man.
authors.affiliation: Laboratoire de Physiologie et de Psychologie Environnementales, CNRS, Strasbourg, France. gronfier@C-strasbourg.fr
authors.forename: C
authors.initials: C
authors.lastname: Gronfier
authors.forename: R
authors.initials: R
authors.lastname: Luthringer
authors.forename: M
authors.initials: M
authors.lastname: Follenius
authors.forename: N
authors.initials: N
authors.lastname: Schaltenbrand
authors.forename: J P
authors.initials: JP
authors.lastname: Macher
authors.forename: A
authors.initials: A
authors.lastname: Muzet
authors.forename: G
authors.initials: G
authors.lastname: Brandenberger
mesh_terms: D000328:Adult; D000513:Alpha Rhythm; D002940:Circadian Rhythm / Q000502:physiology; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D008297:Male; D016713:Ritanserin / Q000008:administration & dosage; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D013972:Thyrotropin / Q000097:blood*; D013997:Time Factors
chemical_list: D016713:Ritanserin; D013972:Thyrotropin