title: Structural aberrations of chromosome 6 in three uterine smooth muscle tumors.
abstract: Clonal karyotypic alterations of chromosome 6 in three uterine smooth muscle tumors are reported. In all cases an apparently identical breakpoint on the short arm of chromosome 6 was found. Two cases displayed the histologic features of cell-rich myomas with severe nuclear atypia but no clear evidence for malignancy. The remaining case was a primary uterine leiomyosarcoma of an 80-year-old patient showing an apparently balanced reciprocal chromosomal translocation, t(1;6)(p32-33;p21.3), as the sole karyotypic abnormality. This type of aberration has not been reported before in leiomyosarcomas. Because of the nuclear atypia in the other myomas with a breakpoint involving the short arm of chromosome 6 we feel that this cytogenetically recognizable but rare subgroup of uterine smooth muscle tumors warrants a careful clinical follow-up.
authors.affiliation: Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
authors.forename: Y
authors.initials: Y
authors.lastname: Hennig
authors.forename: U
authors.initials: U
authors.lastname: Deichert
authors.forename: C
authors.initials: C
authors.lastname: Stern
authors.forename: A
authors.initials: A
authors.lastname: Ghassemi
authors.forename: B
authors.initials: B
authors.lastname: Thode
authors.forename: U
authors.initials: U
authors.lastname: Bonk
authors.forename: P
authors.initials: P
authors.lastname: Meister
authors.forename: S
authors.initials: S
authors.lastname: Bartnitzke
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D007890:Leiomyosarcoma / Q000235:genetics*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics*