Nisin stimulates oxygen consumption by Staphylococcus aureus and Escherichia coli.
Nisin stimulated oxygen consumption by nongrowing, glucose-metabolizing Staphylococcus aureus and Escherichia coli cells, indicating a protonophore mode of action. A similar stimulation in E. coli cells osmotically stressed to disrupt the outer cell membrane confirmed the cytoplasmic membrane as the site of nisin action and showed that nisin uptake was not prevented by the outer membrane.
Carneiro de Melo
A M
AM
Division of Life Sciences, King's College London, United Kingdom. UDLI163@hazel.cc.kcl.ac.uk
Cook
G M
GM
Miles
R J
RJ
Poole
R K
RK
D004926:Escherichia coli / Q000378:metabolism*; D005520:Food Preservatives / Q000494:pharmacology*; D009561:Nisin / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D013211:Staphylococcus aureus / Q000378:metabolism*
D005520:Food Preservatives; D009561:Nisin