title: Haplotype analysis of the Mexican frameshift Cd 11 (-T) and -28 A->C beta-thalassemia alleles.
abstract: The origins of the -28 A->C and frameshift Cd 11 - T(Fs CD 11-T)alleles were investigated by beta-globin cluster haplotype analysis. These alleles were found in a Mexican mestizo family with beta-thalassemia (beta-thal). The -28 A->C mutation was described previously in Kurdish Jews linked to the most common haplotype in the world(+----++),the same haplotype observed in this Mexican family. Therefore, it is not possible to assess a new origin of the -28 A->C mutation in our population. The Fs Cd 11 -T allele, not reported to date in any other populations, was linked to the -++--+-haplotype (sixth in frequency in the world). This haplotype has not been reported in association with any beta-thal mutant, suggesting a Mexican origin for the Cd 11 -T mutation.
authors.affiliation: Divisiones de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Hospital de Pediatría, Guadalajara, México.
authors.forename: F J
authors.initials: FJ
authors.lastname: Perea
authors.forename: M A
authors.initials: MA
authors.lastname: Esparza
authors.forename: A R
authors.initials: AR
authors.lastname: Villalobos-Arambula
authors.forename: B
authors.initials: B
authors.lastname: Ibarra
authors.forename: J M
authors.initials: JM
authors.lastname: Old
mesh_terms: D000293:Adolescent; D000483:Alleles; D005260:Female; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D008297:Male; D008800:Mexico; D009154:Mutation; D010375:Pedigree; D044465:White People / Q000235:genetics; D017086:beta-Thalassemia / Q000235:genetics*
chemical_list: D005914:Globins