title: A study of premature ovarian failure in Turkish women.
abstract: The parameters that could be responsible for or could be the end results of the premature ovarian failure were evaluated in 100 patients and compared with the same parameters of a control group consisting of 30 ovulatory healthy women with regular menstrual cycles. The incidence of premature ovarian failure was 6.6%. The mean age of the premature ovarian failure group was 39.2 +/- 4.1 years (range 30-58) whereas this was 45.6 +/- 3.1 years (range 39-52) for the control group. The mean menopausal age was 4.0 +/- 4.3 years (range 1-30). The prevalence of being a widow, divorcee or single was high in the premature ovarian failure group (p < 0.01). Of the hormonal and metabolic parameters, thyroid-stimulating hormone (TSH) and high-density lipoprotein (HDL) levels showed significant differences between the two groups (p < 0.01 and p < 0.05, respectively) and of the parameters reflecting bone metabolism, alkaline phosphatase levels showed a significant difference (p < 0.05). The bone mineral densitometric measurement values were lower in the premature ovarian failure group (p < 0.05). Because premature ovarian failure is not a rare disorder and because the patients have an early estrogen deficiency we concluded that, whatever the etiologic factor, hormone replacement therapy needs to be given as early as possible.
authors.affiliation: Dr Zekai Tahir Burak Women's Hospital, Menopause Center, Hamamönü, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Gökmen
authors.forename: N C
authors.initials: NC
authors.lastname: Seçkin
authors.forename: A B
authors.initials: AB
authors.lastname: Sener
authors.forename: G
authors.initials: G
authors.lastname: Ozakşit
authors.forename: S
authors.initials: S
authors.lastname: Ekmekçi
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015519:Bone Density; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D017533:Marital Status; D008593:Menopause; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency / Q000453:epidemiology* / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D014421:Turkey
chemical_list: D008075:Lipoproteins, HDL; D013972:Thyrotropin; D000469:Alkaline Phosphatase