title: Induction chemotherapy via hepatic artery for gallbladder carcinoma.
abstract: The prognosis after surgery for carcinoma of the gallbladder remains poor. Treatment failure is frequently due to loco-regional recurrence in the adjacent liver and regional lymph nodes. We report a case of gallbladder carcinoma with proven involvement of the cystic duct node (Nevin stage IV). Pre-operative intra-arterial induction chemotherapy using two cycles of cisplatin, 5-fluorouracil, doxorubicin and mitomycin C was administered via the common hepatic artery. A radical cholecystectomy was performed 4 weeks later, and histological examination of the resected specimen showed a near total response, with no residual nodal disease. The patient remains well and free of disease 3 years later. Intra-arterial induction chemotherapy warrants further evaluation.
authors.affiliation: Department of Upper Gastrointestinal Surgery and Surgical Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
authors.forename: D T
authors.initials: DT
authors.lastname: Lai
authors.forename: D W
authors.initials: DW
authors.lastname: Storey
authors.forename: R
authors.initials: R
authors.lastname: Waugh
authors.forename: F O
authors.initials: FO
authors.lastname: Stephens
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D005706:Gallbladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged