Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma.
Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30-positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study.
Weisenburger
D D
DD
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.
Gordon
B G
BG
Vose
J M
JM
Bast
M A
MA
Chan
W C
WC
Greiner
T C
TC
Anderson
J R
JR
Sanger
W G
WG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005819:Genetic Markers; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged
D014408:Biomarkers, Tumor; D005819:Genetic Markers