title: Three-dimensional gadolinium-enhanced MR angiography of the thoracic aorta.
abstract: OBJECTIVE
  Our objective was to evaluate image quality and preliminary clinical experience with three-dimensional gadolinium-enhanced MR angiography of the thoracic aorta.
  
  
  METHODS
  Ninety patients with suspected thoracic aorta pathology underwent 97 MR examinations at 1.5 T with a 4-min, three-dimensional spoiled gradient-echo techniques. Gadolinium infusion was timed for maximum arterial contrast during acquisition of the central portion of K-space. No ECG gating or breath-holding was used. All MR examinations were evaluated retrospectively for intravascular signal-to-noise ratio (SNR). In 30 of the 90 patients, results from surgery (n = 11), angiography (n = 12), or both (n = 7) were available. Four radiologists who were unaware of the angiographic or surgical findings assessed each of these 30 examinations for three types of pathology: dissection, coarctation, or aneurysm. The observers also assessed aortic branch vessel patency and vascular anomalies in the 19 patients who had angiographic correlation.
  
  
  RESULTS
  Image quality (determined as SNR) was highest in the aortic arch, upper descending thoracic aorta, and upper abdominal aorta. We saw a small reduction in the SNR in the ascending aorta and lower descending thoracic aorta (p < .0001), attributable to cardiac and respiratory motion. Image quality was not affected by slow flow. MR imaging correctly diagnosed pathology in all 30 patients with angiographic or surgical correlation, including eight dissections, three coarctations, and 10 aneurysms. The type of the dissection was correctly determined in all eight patients. Stenoses of major branch vessel origins were detected with a sensitivity of 90% (95% bayesian confidence interval, 99-63%) and a specificity of 96% (95% bayesian confidence interval, 99-89%) in the 19 patients with angiographic correlation. Five vascular anomalies, including an aberrant right subclavian artery, a bovine arch, and three accessory renal arteries, were correctly identified.
  
  
  CONCLUSIONS
  Three-dimensional gadolinium-enhanced MR angiography has the potential to accurately diagnose aortic dissection, coarctation, and aneurysm. It does not require ECG gating or breath-holding and thereby extends the diagnostic utility of MR imaging for the thoracic aorta.
authors.affiliation: Department of Radiology, University of Michigan Hospital, Ann Arbor 48109-0030, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Prince
authors.forename: D L
authors.initials: DL
authors.lastname: Narasimham
authors.forename: W T
authors.initials: WT
authors.lastname: Jacoby
authors.forename: D M
authors.initials: DM
authors.lastname: Williams
authors.forename: K J
authors.initials: KJ
authors.lastname: Cho
authors.forename: M V
authors.initials: MV
authors.lastname: Marx
authors.forename: G M
authors.initials: GM
authors.lastname: Deeb
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000175:diagnosis; D001013:Aorta, Thoracic / Q000473:pathology*; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis; D001017:Aortic Coarctation / Q000175:diagnosis; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005682:Gadolinium