A case of therapy-related extramedullary acute promyelocytic leukemia.
We report a patient with extramedullary acute promyelocytic leukemia (APL) occurring after radiation therapy for carcinoma of the prostate. To the authors' knowledge, this patient represents the first case of cytogenetically and fluorescence in situ hybridization (FISH) confirmed therapy-related extramedullary APL. In contrast to the majority of previously reported t-APL, this case underwent a very unfavorable course.
Chen
Z
Z
Genetrix, Inc., Scottsdale, Arizona 85251, USA.
Mostafavi
H S
HS
Shevrin
D H
DH
Morgan
R
R
Vye
M V
MV
Stone
J F
JF
Sandberg
A A
AA
D000368:Aged; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000209:etiology* / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000097:blood / Q000209:etiology* / Q000235:genetics; D008297:Male; D016609:Neoplasms, Second Primary / Q000097:blood / Q000209:etiology* / Q000235:genetics; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D014178:Translocation, Genetic