Metal-saccharide chemistry and biology: saccharide complexes of zinc and their effect on metallothionein synthesis in mice.
Monosaccharide (D-Fru, D-Gal, D-Glc, D-Xyl, and D-Rib) and disaccharide (Mal) complexes of Zn2+ were synthesized using different precursors and isolated in the solid state. These were found to be anionic with a Zn-to-saccharide ratio of 1:1 and 2:1 for monosaccharide and disaccharide complexes, respectively. Electrochemical behaviour in aqueous solution was studied by extensive cyclic voltammetric studies in the pH range 3.7-10.3. The effect of subcutaneously injected Zn-D-Fru, Zn-D-Gal and Zn-D-Glc complexes on the metallothionein synthesis in mice was found to be significant in the liver, but not in the brain.
Bandwar
R P
RP
Department of Chemistry, Indian Institute of Technology, Powai, Bombay, India.
Giralt
M
M
Hidalgo
J
J
Rao
C P
CP
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004187:Disaccharides; D005632:Fructose; D005690:Galactose; D005947:Glucose; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008320:Maltose; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D009005:Monosaccharides / Q000494:pharmacology*; D012266:Ribose; D017550:Spectroscopy, Fourier Transform Infrared; D015032:Zinc / Q000494:pharmacology*
D004187:Disaccharides; D009005:Monosaccharides; D005632:Fructose; D012266:Ribose; D008320:Maltose; D008668:Metallothionein; D005947:Glucose; D015032:Zinc; D005690:Galactose