title: [Programmed neuronal cell death?].
abstract: During normal development of the nervous system, up to 50 percent or more neuronal and glial cells die by programmed cell death. In the developing neuron, a continual access to neurotrophic factors is required for survival of the cells. The death may be a passive process, and the absence of neurotrophic factors leads to a loss of metabolic activity and, ultimately to cellular degeneration. Alternatively, apoptosis may be a metabolically active process and neurotrophic factors are necessary to repress the "suicide" response of the cell. The role of intracellular calcium, RNA-synthesis, protein synthesis a gene expression is discussed.
authors.affiliation: Fyziologický ústav, 1. Lékarské fakulty, Univerzity Karlovy, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Langmeier
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009474:Neurons / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors