Trypanosoma congolense: high erythropoietic potential in infected yearling cattle during the acute phase of the anemia.
N'Dama (Bos taurus) cattle are known to tolerate trypanosome infections, developing less severe anemia and lower parasitemia, compared to Boran (Bos indicus) cattle. Young calves were also reported to be more resistant to trypanosomiasis than adult cattle. To explore the basis for this resistance, the erythropoietic response was evaluated in four native yearling N'Dama calves and four age-matched Boran calves which developed anemia over a 140- day primary infection with Trypanosoma congolense clone IL 13E3. Similar levels of parasites were detected in the two breeds until 42 days postinfection (dpi). During the same period, a rapid and greater colony-forming units-erythroid response in the bone marrow of yearling Boran calves, compared with N'Dama calves, may explain the unusual absence of breed differences in mean packed cell volumes (PCV). However, this early erythropoietic response was transient and did not result in any rise in PCV from 70 dpi onward. In contrast, in the N'Dama calves, following the erythroid response, the mean PCV was gradually compensated from 56 dpi onward and reached 30% by 126 dpi. This period of PCV recovery coincided with low and intermittent parasitemia and a return of the erythroid progenitor levels to near preinfection values. Elevated levels of erythroid progenitors in the N'Dama calves, occurring 1 week after trypanocidal treatment, returned the PCV to preinfection values. These results suggest that the age of the Bos indicus cattle has an important impact on the early bone marrow response in primary T. congolense infection and confirmed previous suggestions of a high erythropoietic potential in trypanosome-infected young calves.
Andrianarivo
A G
AG
International Livestock Research Institute, Nairobi, Kenya.
Muiya
P
P
Logan-Henfrey
L L
LL
D000208:Acute Disease; D000704:Analysis of Variance; D000740:Anemia / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D001854:Bone Marrow Cells; D001947:Breeding; D002417:Cattle; D004906:Erythrocyte Count / Q000662:veterinary; D004909:Erythrocyte Indices / Q000662:veterinary; D015672:Erythroid Precursor Cells / Q000166:cytology; D004920:Erythropoiesis; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D008297:Male; D018512:Parasitemia / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D012156:Reticulocytes / Q000166:cytology; D014348:Trypanosoma congolense / Q000276:immunology*; D014353:Trypanosomiasis, African / Q000097:blood / Q000276:immunology / Q000662:veterinary; D014354:Trypanosomiasis, Bovine / Q000097:blood / Q000276:immunology*