title: Risk of stroke in a cohort of 815 patients with calcification of the aortic valve with or without stenosis.
abstract: OBJECTIVE
  We sought to establish the possible role of calcification of the aortic valve with or without stenosis as a risk factor for stroke.
  
  
  METHODS
  Occurrences of stroke, stroke subtypes, and concomitant cardiovascular risk factors were prospectively analyzed in 300 patients with echocardiographic evidence of aortic valve calcification, 515 patients with calcified aortic valve stenosis, and 562 control subjects.
  
  
  RESULTS
  Twenty-four patients with aortic valve calcification, 24 patients with calcified aortic valve stenosis, and 27 control subjects had a stroke during follow-up. Using Cox proportional hazards models, we found that strokes were not significantly associated with aortic valve calcification with or without stenosis, but hypertension and any carotid stenosis were associated. On multiple logistic regression analysis, we did not find any association between one of the two valve lesions and indirect possible indications of cardiogenic embolism such as territorial as opposed to small deep brain infarcts or the presence of silent brain infarcts.
  
  
  CONCLUSIONS
  Aortic valve calcification with or without stenosis is not a risk factor for stroke.
authors.affiliation: Department of Neurology, St-Anna Hospital, Geldrop, Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Boon
authors.forename: J
authors.initials: J
authors.lastname: Lodder
authors.forename: E
authors.initials: E
authors.lastname: Cheriex
authors.forename: F
authors.initials: F
authors.lastname: Kessels
mesh_terms: D000367:Age Factors; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001021:Aortic Valve / Q000000981:diagnostic imaging; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000401:mortality; D001241:Aspirin / Q000627:therapeutic use; D002114:Calcinosis / Q000000981:diagnostic imaging; D002423:Cause of Death; D002544:Cerebral Infarction / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000401:mortality; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D014463:Ultrasonography
chemical_list: D000925:Anticoagulants; D001241:Aspirin