The effects of ruthenium red, an inhibitor of calcium-induced calcium release, on phasic myometrial contractions.
Ruthenium red inhibits calcium-induced calcium release from the ryanodine-sensitive intracellular calcium stores; this study sought to evaluate the effects of ruthenium red on agonist-stimulated phasic myometrial contractions. Ruthenium red was found to significantly inhibit in vitro isometric contractions stimulated in response to oxytocin, prostaglandin F2 alpha, aluminum fluoride, potassium chloride, ionomycin, and Bay K 8644. These observations provide support for the hypothesis that calcium-induced calcium release from ryanodine-sensitive calcium stores is an important event during agonist-stimulated phasic myometrial contractions.
Phillippe
M
M
Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637, USA.
Basa
A
A
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015237:Dinoprost / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009215:Myometrium / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011982:Receptors, Prostaglandin / Q000378:metabolism; D012430:Ruthenium Red / Q000494:pharmacology*
D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; D012430:Ruthenium Red; D015237:Dinoprost; D002118:Calcium