[The experimental and clinical aspects of eicosapentaenoic amd docosahexaenoic acids (a review of the literature and the author's own data)].
The author analyses data from relevant literature as well as results of his own studies on mechanism of angioprotective action of higher polyunsaturated fatty acids, such as eicosapentaenic and docosahexaenic ones in particular. The most important effect of the diet saturated with the above acids is conditioned by their influence on the cellular membrane lipid composition, activity of membrane-associated enzymes, prostaglandin system, and, above all, synthesis of prostacyclin and thromboxane. The ability of exogenous polyunsaturated fatty acids to get incorporated into membrane phospholipids of blood constituents and endothelial cells of blood vessels appears to influence the basic properties of plasmolemma and function of receptors. Angioprotective properties of eicosapentaenic and docosahexaenic acids having been confirmed experimentally and in clinical settings, the preparation of these acids was considered liable to be of help in prophylaxis and treatment of vascular affections, in particular, those of a diabetic nature.
Serhiienko
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D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism; D002317:Cardiovascular Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000378:metabolism / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000493:pharmacokinetics / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D002317:Cardiovascular Agents; D004042:Dietary Fats, Unsaturated; D008563:Membrane Lipids; D010743:Phospholipids; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid