title: Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies.
abstract: In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose.
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Detroit, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: McCarver-May
authors.forename: J
authors.initials: J
authors.lastname: Kang
authors.forename: M
authors.initials: M
authors.lastname: Aouthmany
authors.forename: R
authors.initials: R
authors.lastname: Elton
authors.forename: J L
authors.initials: JL
authors.lastname: Mowery
authors.forename: T L
authors.initials: TL
authors.lastname: Slovis
authors.forename: R
authors.initials: R
authors.lastname: Kauffman
mesh_terms: D002697:Chloral Hydrate / Q000494:pharmacology; D016292:Procedural Sedation; D018592:Cross-Over Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007231:Infant, Newborn; D008874:Midazolam / Q000494:pharmacology; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate; D008874:Midazolam