title: Partial epilepsy of long duration: changing semiology with age.
abstract: There are few data on changing patterns of localization-related epileptic syndromes with time and particularly on changes in seizure semiology as patients age. We retrospectively reviewed 53 patients aged > 60 years who had had partial epileptic seizures for a mean duration of 44 years. In 29 patients, seizures became progressively less elaborate and briefer with time. In 20 patients, seizures were unchanged. In four patients, seizures worsened, with the appearance of drop attacks, secondarily generalized seizures, increasing drug resistance, and mental deterioration. These latter 4 patients had cerebrovascular disease with multiple strokes.
authors.affiliation: Neurological Institute, University of Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tinuper
authors.forename: F
authors.initials: F
authors.lastname: Provini
authors.forename: C
authors.initials: C
authors.lastname: Marini
authors.forename: A
authors.initials: A
authors.lastname: Cerullo
authors.forename: G
authors.initials: G
authors.lastname: Plazzi
authors.forename: P
authors.initials: P
authors.lastname: Avoni
authors.forename: A
authors.initials: A
authors.lastname: Baruzzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D018450:Disease Progression; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000453:epidemiology; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011379:Prognosis