title: Association of interleukin-10 with rejection-sparing effect in septic kidney transplant recipients.
abstract: Certain cytokines, particularly gamma-interferon (IFN) and interleukin (IL)-2 associated with TH1 cell function, have been shown to play a role in allograft rejection. One paradigm for long-term allograft acceptance involves TH2 cytokine predominance (IL-4 and IL-10). We describe two renal allograft recipients for whom immunosuppression was discontinued due to serious sepsis and who maintained stable renal function over 2-6 months without immunosuppression. During this time, there were higher levels of both IFN-gamma and IL-10 in the peripheral blood than in stable control kidney transplant recipients on immunosuppression. In one of the patients, levels of IL-10 fell, while those of IFN-gamma remained persistently elevated. This was associated with biopsy-proven rejection. Although peripheral blood cytokine levels may not reflect intragraft events, these data are consistent with an allograft protective role for IL-10 offsetting that of IFN-gamma in both patients off immunosuppression.
authors.affiliation: Department of Surgery, Division of Transplantation, University of Miami Medical Center, Florida 33136, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Burke
authors.forename: G
authors.initials: G
authors.lastname: Ciancio
authors.forename: R
authors.initials: R
authors.lastname: Cirocco
authors.forename: M
authors.initials: M
authors.lastname: Markou
authors.forename: D
authors.initials: D
authors.lastname: Coker
authors.forename: D
authors.initials: D
authors.lastname: Roth
authors.forename: J
authors.initials: J
authors.lastname: Nery
authors.forename: V
authors.initials: V
authors.lastname: Esquenazi
authors.forename: J
authors.initials: J
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D007371:Interferon-gamma / Q000502:physiology; D016753:Interleukin-10 / Q000502:physiology*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D014184:Transplantation, Homologous
chemical_list: D016753:Interleukin-10; D007371:Interferon-gamma