title: Pulmonary lymphangioleiomyomatosis: a case report in postmenopausal woman treated with pleurodesis and progesterone (medroxyprogesterone acetate).
abstract: The main problem in the treatment of pulmonary lymphangioleiomyomatosis, which frequently occurs in the reproductive age, is the control of chylothorax and disease progression. We herein report a case of a 62-year-old woman who underwent surgery for recurrent chylothorax. Histologic examination of lung and lymph node biopsies demonstrated lymphangioleiomyomatosis. Thirty-six months after tetracycline pleurodesis and high-dose medroxyprogesterone acetate therapy, the disease was stable and cyclothorax effectively controlled. It would therefore appear that hormonal treatment with medroxyprogesterone acetate may be beneficial in postmenopausal women.
authors.affiliation: Istituto di Clinica Chirurgica II, Universita di Padova, Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zanella
authors.forename: P
authors.initials: P
authors.lastname: Toppan
authors.forename: D
authors.initials: D
authors.lastname: Nitti
authors.forename: M
authors.initials: M
authors.lastname: Lise
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D018192:Lymphangioleiomyomatosis / Q000628:therapy*; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D008875:Middle Aged; D018700:Pleurodesis; D017698:Postmenopause
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017258:Medroxyprogesterone Acetate