title: The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: in vivo and in vitro studies.
authors.affiliation: Division of Pharmaceutical Science, Kyushu University, Fukuoka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Ieiri
authors.forename: W
authors.initials: W
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: A
authors.initials: A
authors.lastname: Toshitani
authors.forename: S
authors.initials: S
authors.lastname: Imayama
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Ohtsubo
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D013237:Stereoisomerism
chemical_list: D000927:Anticonvulsants; C027364:5-(3-hydroxyphenyl)-5-phenylhydantoin; D010672:Phenytoin; D004247:DNA