Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC.
We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.
Lissy
N A
NA
Department of Medical Oncology, Fox Chase Cancer Center, Phildelphia, PA 19111, USA.
Bellacosa
A
A
Sonoda
G
G
Miller
P D
PD
Jhanwar
S C
SC
Testa
J R
JR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D017124:Conserved Sequence; D018076:DNA, Complementary; D006602:Hexosyltransferases; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D008565:Membrane Proteins; D006602:Hexosyltransferases; C099573:STT3A protein, human