title: Changes within T cell receptor V beta subsets in infants following measles vaccination.
abstract: Measles produces immune suppression which contributes to an increased susceptibility to other infections. Recently, high titered measles vaccines have been linked to increased long-term mortality among some female recipients. Because the mechanisms by which wild-type or attenuated live-vaccine strains of measles virus alter subsequent immune responses are not fully understood, this prompted an examination of the changes within the peripheral blood T cell receptor V beta repertoire following measles immunization. Twenty-four 6- and 9-month-old infants were studied at 2 weeks and 3 months following immunization by semiquantitative reverse transcription-polymerase chain reaction. There was a significant increase in V beta 2 expression (P less than 0.05), and a decrease in the V beta 4 subset (P less than 0.03) 2 weeks following vaccination with subsequent return to baselines at 3 months in vaccine recipients who seroconverted. These data suggest that measles virus may affect immune responses in part by altering the T cell receptor repertoire.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, John Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Auwaerter
authors.forename: G D
authors.initials: GD
authors.lastname: Hussey
authors.forename: E A
authors.initials: EA
authors.lastname: Goddard
authors.forename: J
authors.initials: J
authors.lastname: Hughes
authors.forename: J J
authors.initials: JJ
authors.lastname: Ryon
authors.forename: P M
authors.initials: PM
authors.lastname: Strebel
authors.forename: D
authors.initials: D
authors.lastname: Beatty
authors.forename: D E
authors.initials: DE
authors.lastname: Griffin
mesh_terms: D001483:Base Sequence; D005260:Female; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D008297:Male; D008458:Measles Vaccine / Q000009:adverse effects*; D008969:Molecular Sequence Data; D010835:Phytohemagglutinins / Q000494:pharmacology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000009:adverse effects
chemical_list: D008458:Measles Vaccine; D010835:Phytohemagglutinins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D014613:Vaccines, Attenuated