Two new DNA synthesis inhibitors with potent immunosuppressive activity prolong allograft and xenograft survival in small and large animals.
Goodman
E R
ER
Department of Surgery, Columbia University, New York, New York 10032, USA.
Fiedor
P S
PS
Fein
S
S
Sung
R S
RS
Athan
E
E
Hardy
M A
MA
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002460:Cell Line; D017338:Cladribine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008212:Lymphocyte Depletion; D008252:Macaca fascicularis; D051381:Rats; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D016038:Skin Transplantation / Q000276:immunology*; D013045:Species Specificity; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology; D001084:Vidarabine Phosphate / Q000031:analogs & derivatives* / Q000494:pharmacology
D007166:Immunosuppressive Agents; D001084:Vidarabine Phosphate; C042382:fludarabine phosphate; D017338:Cladribine