title: Streptococcus mitis cell walls and lipopolysaccharide induce lethality in D-galactosamine-sensitized mice by a tumor necrosis factor-dependent pathway.
abstract: Purified cells walls of Streptococcus mitis induced tumor necrosis factor in vitro in whole blood of both lipopolysaccharide (LPS)-sensitive OF1 and LPS-resistant C3H/HeJ mice. They were as effective as heat-killed bacteria in inducing death in both strains of mice sensitized with D-galactosamine. Lethality was suppressed by anti-tumor necrosis factor antibodies. The histopathophysiological findings in mice after challenge with LPS or gram-positive cell walls were indistinguishable.
authors.affiliation: Department of Medicine, CHUV-Lausanne, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Le Roy
authors.forename: P
authors.initials: P
authors.lastname: Morand
authors.forename: S
authors.initials: S
authors.lastname: Lengacher
authors.forename: M
authors.initials: M
authors.lastname: Celio
authors.forename: G E
authors.initials: GE
authors.lastname: Grau
authors.forename: M P
authors.initials: MP
authors.lastname: Glauser
authors.forename: D
authors.initials: D
authors.lastname: Heumann
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D002473:Cell Wall / Q000276:immunology*; D005688:Galactosamine / Q000276:immunology*; D007114:Immunization; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009504:Neutrophils / Q000473:pathology / Q000502:physiology; D012772:Shock, Septic / Q000209:etiology; D013290:Streptococcal Infections / Q000209:etiology; D013291:Streptococcus / Q000276:immunology* / Q000472:pathogenicity*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D005688:Galactosamine