title: High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome.
abstract: OBJECTIVE
  To study the outcome in poor responders to three ampules (225 IU) of hMG per day in subsequent IVF treatment cycles in which six ampules (450 IU)of hMG per day were administered.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Academic tertiary center.
  
  
  METHODS
  Between January 1988 and May 1995, 126 poor response patients had a first treatment cycle on three ampules and a second cycle on six ampules of hMG per day.
  
  
  METHODS
  Numbers of follicles, oocytes, and embryos, and pregnancy rates.
  
  
  RESULTS
  On six ampules, patients had significantly more follicles and oocytes. The number of embryos did not differ significantly. The pregnancy rate on six ampules were low (3.2% pregnancies per cycle started).
  
  
  CONCLUSIONS
  Poor responders do not benefit from high-dose hMG stimulation; their reproduction outcome is poor.
authors.affiliation: Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Maastricht, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Land
authors.forename: M I
authors.initials: MI
authors.lastname: Yarmolinskaya
authors.forename: J C
authors.initials: JC
authors.lastname: Dumoulin
authors.forename: J L
authors.initials: JL
authors.lastname: Evers
mesh_terms: D000328:Adult; D004622:Embryo, Mammalian; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage* / Q000627:therapeutic use*; D009865:Oocytes / Q000166:cytology; D006080:Ovarian Follicle / Q000502:physiology; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D008596:Menotropins; D005640:Follicle Stimulating Hormone