title: Elevated mutation rate in mutT bacteria during starvation: evidence for DNA turnover?
abstract: The rate of appearance of prototrophic revertants when Escherichia coli tyrA14 (ochre) or trpA23 bacteria were incubated on plates lacking the required amino acid was greatly elevated when the organisms also carried a mutT mutation. One possible explanation for this result is that the amount of DNA replication or turnover under these conditions is much greater than has been previously recognized.
authors.affiliation: MRC Cell Mutation Unit, University of Sussex, Brighton, Great Britain.
authors.forename: B A
authors.initials: BA
authors.lastname: Bridges
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000378:metabolism*; D043382:DNA-Formamidopyrimidine Glycosylase; D003848:Deoxyguanine Nucleotides / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins; D009097:Multienzyme Complexes; D016296:Mutagenesis / Q000235:genetics*; D009153:Mutagens / Q000378:metabolism; D009154:Mutation; D009699:N-Glycosyl Hydrolases / Q000235:genetics; D010641:Phenotype; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D011755:Pyrophosphatases; D014443:Tyrosine / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D003848:Deoxyguanine Nucleotides; D029968:Escherichia coli Proteins; D009097:Multienzyme Complexes; D009153:Mutagens; C076398:TyrA protein, Bacteria; C078206:8-oxodeoxyguanosine triphosphate; D014443:Tyrosine; D010744:Phosphoric Monoester Hydrolases; D009699:N-Glycosyl Hydrolases; D043382:DNA-Formamidopyrimidine Glycosylase; C468610:DNA-formamidopyrimidine glycosylase, E coli; D011755:Pyrophosphatases; C052211:mutT protein, E coli