title: [Droxicam-induced toxic hepatitis].
abstract: We present four cases of hepatitis with clinical features indicating a direct link with Droxicam. In all the cases, the presentation was that of acute hepatitis with subsequent resolution, whereas one patient developed autoimmune chronic active hepatitis. A full evaluation including ultrasound, liver biopsy, and serologic markers supported the diagnosis. Due to the fact that the "Dirección General de Farmacia y Productos Sanitarios" has approved the postponement of dispensation of products with Droxicam from February 25, 1995, this drug should not be considered anymore in the future as a potential cause of liver injury (acute or chronic hepatitis).
authors.affiliation: Servicio de Medicina Digestivo, Hospital La Fe, Valencia.
authors.forename: M
authors.initials: M
authors.lastname: Berenguer
authors.forename: F
authors.initials: F
authors.lastname: Pérez-Aguilar
authors.forename: C
authors.initials: C
authors.lastname: Gisbert
authors.forename: L A
authors.initials: LA
authors.lastname: Ferreres
authors.forename: F J
authors.initials: FJ
authors.lastname: Vera-Sempere
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011725:Pyridines; C049073:droxicam