title: [Evaluation of the antihypertensive efficacy of urapidil in the treatment of hypertension emergencies].
abstract: Hypertensive crisis is defined as an acute elevation of the blood pressure involving the risk of life. Agents used to the treatment of hypertensive emergencies should lower the blood pressure under control and produce minimal adverse effect. The aim of this study was to evaluate the antihypertensive efficacy of urapidil i.v. in hypertensive emergencies. Twenty three patients (pts) with the hypertensive crisis in association with ischaemic heart disease and/or acute left ventricular failure were studied. Urapidil was given intravenously in the emergent treatment to the group of 23 pts in the mean dose of 50 mg. Systolic (RRs) diastolic blood pressure (RRd) and heart rate were measured within 4 hours after the drug administration. In this group of pts the significant decrease in RRs and RRd after 2 min. of administration of urapidil was observed and the maximum effect (p < 0.05) occurred within 40 min. The heart rate decreased by 8% and was significantly different (p < 0 > 05) at the maximum point of the drug action. Urapidil administered in 25-75 mg i.v. appeared an effective antihypertensive agent in more than 90% of patients with hypertensive emergencies. What was striking, no reflex tachycardia was observed after i.v. administration of urapidil despite its antihypertensive action.
authors.affiliation: I Klinika Kardiologii AM w Poznaniu.
authors.forename: K
authors.initials: K
authors.lastname: Błaszyk
authors.forename: S
authors.initials: S
authors.lastname: Grajek
authors.forename: W
authors.initials: W
authors.lastname: Skorupski
authors.forename: M
authors.initials: M
authors.lastname: Popiel
authors.forename: H
authors.initials: H
authors.lastname: Wnuk
authors.forename: P
authors.initials: P
authors.lastname: Mitkowski
authors.forename: A
authors.initials: A
authors.lastname: Cieśliński
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004630:Emergencies; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D010879:Piperazines / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left / Q000150:complications
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil