title: Transient congenital hypothyroidism and hyperthyrotropinemia: normal thyroid function and physical development at the ages of 6-14 years.
abstract: Since the introduction of screening programs for congenital hypothyroidism, transient disturbances of thyroid function, especially transient congenital hypothyroidism and hyperthyrotropinemia, mostly due to iodine deficiency or contamination have been observed with variable frequencies. This study was carried out to reevaluate the thyroid function and physical development of 61 schoolchildren with transient congenital hypothyroidism or transient congenital hyperthyrotropinemia. Abnormalities were observed in 3 children. Thyroid function and growth were normal in all children, except 2 with moderately elevated TSH levels at the age of 7.7 and 10 yr in the presence of normal thyroid hormone levels. In 1 child, the TSH elevation was due to an ectopic hemithyroidea; in the other child, an unknown familial cause was suggested. In 1 girl (aged 12 yr), a euthyroid goiter caused by autoimmune thyroiditis was detected. We conclude from our investigation that frequent monitoring of thyroid function in children with transient congenital hypothyroidism or transient congenital hyperthyrotropinemia is not necessary during childhood if, postnatally, thyroid function recovered spontaneously. However, the growth and development of children with neonatal thyroid dysfunction should be followed, and if abnormalities occur, thyroid function tests are essential.
authors.affiliation: Department of Pediatric Endocrinology, Klinikum Rudolf Virchow, Humboldt University of Berlin, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Köhler
authors.forename: D
authors.initials: D
authors.lastname: Schnabel
authors.forename: H
authors.initials: H
authors.lastname: Biebermann
authors.forename: A
authors.initials: A
authors.lastname: Gruters
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology*; D002648:Child; D005260:Female; D005865:Gestational Age; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007455:Iodine / Q000172:deficiency; D008297:Male; D012075:Remission, Spontaneous; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine