[HPLC analysis of non-steroidal antirheumatic agents in biological material. I. Salicylates].
The present paper surveys both published HPLC methods estimating salicylates in biological materials and an HPLC method for estimation of salicylic acid and its metabolites in the samples of whole blood, isolated erythrocytes and plasma. For liquid-liquid extraction, salicylates were analyzed on reverse phases Separon SGX C18 with the mobile phase methanol-water (pH 2,5) and detected at 236 nm. The elaborated method was used in a pharmacokinetic study of salicylates on rabbits.
Sochor
J
J
Katedra farmaceutické chemie a kontroly léciv Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
Klimes
J
J
Sedlácek
J
J
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D011817:Rabbits; D012459:Salicylates / Q000097:blood* / Q000493:pharmacokinetics
D012459:Salicylates