The Santa Lucia strain of Plasmodium falciparum as a model for vaccine studies. II. Development of Aotus vociferans as a model for testing transmission-blocking vaccines.
The Santa Lucia strain of Plasmodium falciparum and the Aotus vociferans monkey were studied as models for the testing of transmission-blocking vaccines. Virulence developed early in the passage history. Despite the use of only small quantities of chlorguanide and/or quinine to control infection coupled with the use of small inocula and delays in splenectomy, mosquito infection was markedly reduced from that seen during primary passage to this species of Aotus. It appears that the model may be most useful during its initial passage from the primary species, Aotus lemurinus griseimembra.
Collins
W E
WE
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Galland
G G
GG
Sullivan
J S
JS
Morris
C L
CL
Richardson
B B
BB
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000962:Antimalarials / Q000627:therapeutic use; D016645:Aotidae; D002675:Child, Preschool; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000517:prevention & control* / Q000635:transmission; D018512:Parasitemia / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission; D010963:Plasmodium falciparum / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D002727:Proguanil / Q000627:therapeutic use; D011803:Quinine / Q000627:therapeutic use; D012692:Serial Passage; D013156:Splenectomy; D014774:Virulence
D000962:Antimalarials; D017780:Malaria Vaccines; D011803:Quinine; D002727:Proguanil