title: The significance of aggression and impulsivity for self-mutilative behavior.
abstract: Self-mutilative behavior (SMB) is presented as a specific form of inwardly directed aggressiveness which is thought to be associated with problems of impulse control. Conceptual problems concerning impulsivity and impulsive aggression are discussed. Among different forms of dyscontrolled behavior, SMB is of special heuristic interest because of distinction can be made between patients committing impulsive and those committing premeditated self-harming actions. Psychometric and biological measures of impulsivity and aggressiveness were assessed in self-mutilators in comparison to depressives and normal probands. Self-mutilators were differentiated into two subgroups, those with an impulsive (ISMB) and those with a premeditated (PSMB) form of SMB, and depressives were also differentiated into two subgroups, those with a history of suicide attempts and those without. Only patients with ISMB (and depressives with a history of suicide attempts) showed an enduring tendency towards dyscontrolled patterns of behavior and cognition; therefore, SMB cannot be generally regarded as an indicator of high impulsivity or an impulse control disorder. Measures of impulsivity and aggressiveness did not behave analogically to each other and aggressive or autoaggressive modes of behavior should not be generally used as an index of impulsivity. A reduction of serotonergic activity, proved by a blunted prolactin response to D-fenfluramine, was found in all patient-groups in comparison to normal probands. Prolactin response after D-fenfluramine challenge turned out to be most blunted among self-mutilators with ISMB and among depressives with a history of suicide attempts.
authors.affiliation: Psychiatric Clinic of the Technical University of Aachen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Herpertz
authors.forename: S M
authors.initials: SM
authors.lastname: Steinmeyer
authors.forename: D
authors.initials: D
authors.lastname: Marx
authors.forename: A
authors.initials: A
authors.lastname: Oidtmann
authors.forename: H
authors.initials: H
authors.lastname: Sass
mesh_terms: D000328:Adult; D000374:Aggression / Q000523:psychology*; D015415:Biomarkers; D003863:Depression / Q000523:psychology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D005277:Fenfluramine; D006801:Humans; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D012652:Self Mutilation / Q000523:psychology*; D013406:Suicide, Attempted / Q000523:psychology
chemical_list: D015415:Biomarkers; D005277:Fenfluramine