title: A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.
abstract: Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non-and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.
authors.affiliation: Human Genetics Center, University of Texas Health Science Center at Houston 77030, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Hanis
authors.forename: E
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: R
authors.initials: R
authors.lastname: Chakraborty
authors.forename: D L
authors.initials: DL
authors.lastname: Ellsworth
authors.forename: P
authors.initials: P
authors.lastname: Concannon
authors.forename: B
authors.initials: B
authors.lastname: Stirling
authors.forename: V A
authors.initials: VA
authors.lastname: Morrison
authors.forename: B
authors.initials: B
authors.lastname: Wapelhorst
authors.forename: R S
authors.initials: RS
authors.lastname: Spielman
authors.forename: K J
authors.initials: KJ
authors.lastname: Gogolin-Ewens
authors.forename: J M
authors.initials: JM
authors.lastname: Shepard
authors.forename: S R
authors.initials: SR
authors.lastname: Williams
authors.forename: N
authors.initials: N
authors.lastname: Risch
authors.forename: D
authors.initials: D
authors.lastname: Hinds
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: M
authors.initials: M
authors.lastname: Ogata
authors.forename: Y
authors.initials: Y
authors.lastname: Omori
authors.forename: C
authors.initials: C
authors.lastname: Petzold
authors.forename: H
authors.initials: H
authors.lastname: Rietzch
authors.forename: H E
authors.initials: HE
authors.lastname: Schröder
authors.forename: J
authors.initials: J
authors.lastname: Schulze
authors.forename: N J
authors.initials: NJ
authors.lastname: Cox
authors.forename: S
authors.initials: S
authors.lastname: Menzel
authors.forename: V V
authors.initials: VV
authors.lastname: Boriraj
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: L R
authors.initials: LR
authors.lastname: Lim
authors.forename: T
authors.initials: T
authors.lastname: Lindner
authors.forename: L E
authors.initials: LE
authors.lastname: Mereu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Xiang
authors.forename: K
authors.initials: K
authors.lastname: Yamagata
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
mesh_terms: D002889:Chromosomes, Human, Pair 2; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D017058:Mexican Americans / Q000235:genetics*; D044465:White People
chemical_list: D005819:Genetic Markers