The presentation of a hepatitis C viral peptide by distinct major histocompatibility complex class I allotypes from two chimpanzee species.
A cytotoxic T lymphocyte (CTL) line, derived from the liver of a common chimpanzee (Pan troglodytes) with hepatitis C, specifically recognized a hepatitis C viral 9-mer peptide (KHP-DATYSR in single-letter amino acid code) bound by the major histocompatibility complex (MHC) class I molecule, Patr-A04. This same CTL line also recognized the identical peptide bound by a structurally different class I molecule, Papa-A06, derived from the separate chimpanzee species, Pan paniscus or pygmy chimpanzee. These class I allotypes differ by six amino acids but, in spite of the structural differences, share the same antigen-presenting function. This is the first observation of antigen presentation to a given T cell receptor by different MHC class I allotypes from separate species.
Cooper
S
S
Department of Structural Biology and Microbiology, Stanford University School of Medicine, California 94305-5400, USA.
Kowalski
H
H
Erickson
A L
AL
Arnett
K
K
Little
A M
AM
Walker
C M
CM
Parham
P
P
D000818:Animals; D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D018936:Hepatitis C Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D007525:Isoelectric Focusing; D002679:Pan troglodytes / Q000145:classification / Q000235:genetics / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology
D018936:Hepatitis C Antigens; D015395:Histocompatibility Antigens Class I; D010455:Peptides