title: Histologic evaluation of preauricular and postauricular human skin after high-energy, short-pulse carbon dioxide laser.
abstract: BACKGROUND
  Despite its growing use in dermatalogic surgery, the effects of high-energy, short-pulse carbon dioxide laser on human skin have not been well documented.
  
  
  OBJECTIVE
  To study the histologic effects of this high-energy, short-pulse CO2 laser on human skin and to compare these changes with the effects of standard chemexfoliation procedures.
  
  
  METHODS
  Twenty-four hours after laser administration, there was extensive epidermal necrosis and coagulative change in the superficial papillary dermis. With increasing doses of laser energy, there was a statistically significant increase in the depth of dermal wounding (P<.001 for days 1 and 3, F-test). Reepithelialization occurred in most specimens by day 3. By day 90, most specimens showed a subepidermal dermal repair zone consisting of compact new collagen fibers overlying collagen with evidence of solar elastosis.
  
  
  CONCLUSIONS
  This high-energy, short-pulse CO2 laser produces morphologic changes similar to those seen with medium-depth chemical peels. This laser can ablate skin precisely and bloodlessly with little interference in the wound healing process, suggesting that it may serve as an alternative treatment for photoaged skin.
authors.affiliation: Division of Dermatopathology, Department of Pathology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: J
authors.initials: J
authors.lastname: Cotton
authors.forename: A F
authors.initials: AF
authors.lastname: Hood
authors.forename: R
authors.initials: R
authors.lastname: Gonin
authors.forename: W H
authors.initials: WH
authors.lastname: Beesen
authors.forename: C W
authors.initials: CW
authors.lastname: Hanke
mesh_terms: D000704:Analysis of Variance; D001706:Biopsy; D002245:Carbon Dioxide; D002615:Chemexfoliation; D062109:Dermatologic Surgical Procedures; D004423:Ear; D005145:Face / Q000601:surgery; D005260:Female; D006801:Humans; D017075:Laser Coagulation / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011184:Postoperative Period; D012867:Skin / Q000473:pathology; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide