L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers.
In order to assess associations between the genetic polymorphism of L-myc and glutathione S-transferase M1 (GST M1) and the risk of hepatocellular carcinoma (HCC), a total of 46 surgically treated HCC patients who were seropositive in hepatitis B surface antigen (HBsAg) and 88 HBs-Ag positive controls were recruited for this study. L-myc and GST M1 genetic polymorphism was examined using a polymerase chain reaction-based restriction fragment length polymorphism assay on DNA extracted from liver and peripheral blood samples. There was no significant difference in GST M1 genotypes between HCC patients and matched controls. A gene dosage trend of association with HCC risk was observed for L-myc genotype. The dose-response relationship remained statistically significant in the multiple logistic regression analysis.
Hsieh
L L
LL
Department of Public Health, Chang Gung College of Medicine and Technology, Tao-Yuan, Taiwan, ROC.
Huang
R C
RC
Yu
M W
MW
Chen
C J
CJ
Liaw
Y F
YF
D000367:Age Factors; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000235:genetics; D002353:Carrier State; D016022:Case-Control Studies; D002908:Chronic Disease; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D016259:Genes, myc; D005982:Glutathione Transferase / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
D017931:DNA Primers; D005982:Glutathione Transferase