Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors.
Rotavirus can cause severe gastrointestinal disease, especially in infants and young children, and is particularly prevalent in Third-World countries. Therefore, the development of potential inhibitors of this virus is of great interest. The present study describes the synthesis and in vitro biological evaluation of a number of N-acetylneuraminic acid-based compounds as potential rotavirus inhibitors. Our data suggests that it is indeed possible to inhibit adhesion of the virus, and hence in vitro replication, with carbohydrate-based molecules, although this inhibition does appear to be strain dependent.
Kiefel
M J
MJ
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia.
Beisner
B
B
Bennett
S
S
Holmes
I D
ID
von Itzstein
M
M
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D011817:Rabbits; D012401:Rotavirus / Q000187:drug effects*; D012794:Sialic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D012794:Sialic Acids; D013865:Thioglycosides