title: Pulmonary function changes during epidural anesthesia for cesarean delivery.
abstract: Although changes in pulmonary function in parturients are documented, little is known about effects of regional anesthesia on these changes. This study was undertaken to determine if two local anesthetics, often used for epidural anesthesia for cesarean delivery, have different effects on pulmonary function testing. Nineteen ASA physical status I parturients undergoing elective cesarean delivery with epidural anesthesia were randomly assigned in double-blind fashion to receive either 0.5% bupivacaine or 2% lidocaine with epinephrine (1/200,000). Pulmonary function tests were measured using a calibrated spirometer with computer-recorded flow volume loops. Peak inspiratory pressure and peak inspiratory flow rate, peak expiratory pressure (PEP) and peak expiratory flow rate, forced vital capacity (FVC), and forced expiratory volume in 1 s (FEV1) were measured. Measurements were taken prior to epidural placement and at T-10 and T-4 levels. Peak inspiratory pressure, FEV1/FVC, FEV1, FVC, peak expiratory flow rate, and peak inspiratory flow rate did not differ from baseline in either group. Patients receiving lidocaine showed a significantly greater decrease in PEP at both T-10 and T-4 levels. Pep is largely dependent on abdominal musculature. If a denser motor block is provided by 2% lidocaine with epinephrine than by 0.5% bupivacaine, these muscles would be more affected, resulting in a greater decrease in PEP. These results may have implications regarding choice of local anesthetic for epidural anesthesia in parturients with some degree of respiratory compromise undergoing cesarean delivery.
authors.affiliation: Department of Anesthesia, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: E
authors.initials: E
authors.lastname: Yun
authors.forename: G P
authors.initials: GP
authors.lastname: Topulos
authors.forename: S C
authors.initials: SC
authors.lastname: Body
authors.forename: S
authors.initials: S
authors.lastname: Datta
authors.forename: A M
authors.initials: AM
authors.lastname: Bader
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural / Q000009:adverse effects*; D002045:Bupivacaine / Q000008:administration & dosage; D002585:Cesarean Section / Q000379:methods*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D011247:Pregnancy; D012123:Pulmonary Ventilation / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*
chemical_list: D008012:Lidocaine; D002045:Bupivacaine