[DNA-fingerprinting and tuberculosis].
DNA-fingerprinting or RFLP (Restriction Fragment Length Polymorphism) is a molecular biological technique which allows differentiation between tuberculosis strains. The technique is based on the occurrence of repetitive elements in the mycobacterial genome and is a powerful tool in epidemiological studies. DNA-fingerprinting is also of value in tracking the spread of infection in patients with tuberculosis. The latter is illustrated in two case stories.
Bauer
J O
JO
Mykobakterieafdelingen, Statens Seruminstitut, København.
Clementsen
P S
PS
Faurschou
P
P
D000328:Adult; D016172:DNA Fingerprinting; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014396:Tuberculosis, Pleural / Q000175:diagnosis / Q000235:genetics* / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000235:genetics* / Q000635:transmission