title: Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection.
abstract: This case report describes infantile nephrotic syndrome (NS) in a baby girl with a clinically severe cytomegalovirus (CMV) infection. Culture of the baby's urine was positive for CMV and IgM anti-CMV antibodies were detected. After an unsuccessful course of corticosteroids, gancyclovir treatment was started and a remission of cutaneous, pulmonary, and renal symptoms was achieved. As the mother also developed NS at the end of pregnancy, a common etiology could be postulated, although there were no signs of recent CMV infection in the mother, only anti-CMV IgG. The relationship between CMV infection and glomerular disease is still unclear; NS may represent another manifestation of CMV disease.
authors.affiliation: Department of Pediatrics II, University of Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Giani
authors.forename: A
authors.initials: A
authors.lastname: Edefonti
authors.forename: B
authors.initials: B
authors.lastname: Damiani
authors.forename: G
authors.initials: G
authors.lastname: Marra
authors.forename: D
authors.initials: D
authors.lastname: Colombo
authors.forename: G
authors.initials: G
authors.lastname: Banfi
authors.forename: E
authors.initials: E
authors.lastname: Rivolta
authors.forename: E H
authors.initials: EH
authors.lastname: Strøm
authors.forename: M
authors.initials: M
authors.lastname: Mihatsch
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007075:Immunoglobulin M / Q000652:urine; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D011247:Pregnancy
chemical_list: D000305:Adrenal Cortex Hormones; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M