Chromosome analysis of unfertilized oocytes after in vitro fertilization program: a preliminary report.
To assess the contribution of chromosome anomalies to high failure of in vitro fertilization (IVF), a total of sixty three eggs from 37 women participating in the IVF program were cytogenetically investigated. The mean age of the oocytes donors was 36.8 years. Chromosome karyotype was obtained in 30 of unfertilized oocytes: 16 oocytes (53.3%) had a normal haploid chromosome complement; 5 (16.7%) were hypohaploid; 3 (10.0%) were hyperhaploid; 3 (10.0%) were diploid, 3 (10.0%) were polyploid. It may explain for early pregnancy loss, low pregnancy rate after in vitro fertilization.
Makemaharn
O
O
Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Srivannaboon
S
S
D000022:Abortion, Spontaneous; D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002877:Chromosomes, Human; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D008297:Male; D009865:Oocytes / Q000166:cytology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013081:Sperm Motility; D017211:Treatment Failure