title: Localization of the mouse lissencephaly-1 gene to mouse chromosome 11B3, in close proximity to D11Mit65.
abstract: Lissencephaly is a human brain malformation manifested by a smooth cerebral surface and severe mental retardation. Some of the patients have been shown to have deletions in chromosome 17p13.3, and recently, LIS-1 has been proposed to be the disease-associated gene. We have now mapped the mouse homolog of LIS-1 to mouse chromosome 11B3 by using fluorescence in situ hybridization to metaphase chromosomes. The analysis of yeast artificial chromosome clones placed Lis-1 in close proximity to the microsatellite marker D11Mit65.
authors.affiliation: Department of Biomedical Science, Amgen, Inc., Thousand Oaks, California 91320, USA.
authors.forename: M
authors.initials: M
authors.lastname: Péterfy
authors.forename: J C
authors.initials: JC
authors.lastname: Hozier
authors.forename: B
authors.initials: B
authors.lastname: Hall
authors.forename: T
authors.initials: T
authors.lastname: Gyuris
authors.forename: K
authors.initials: K
authors.lastname: Péterfy
authors.forename: L
authors.initials: L
authors.lastname: Takécs
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000818:Animals; D015139:Blotting, Southern; D001921:Brain / Q000002:abnormalities*; D002874:Chromosome Mapping; D000013:Congenital Abnormalities / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008607:Intellectual Disability / Q000235:genetics; D051379:Mice / Q000235:genetics*; D008869:Microtubule-Associated Proteins; D011506:Proteins / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D008869:Microtubule-Associated Proteins; D011506:Proteins; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C084102:PAFAH1B1 protein, human; C513190:Pafah1b1 protein, mouse