Axonal regeneration.
Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to allow functional recovery. This is due to inhibitors of axonal growth produced by both oligodendrocytes and astrocytes and also to the decreased ability of adult neurons to extend axons during regeneration compared to embryonic neurons during development. However once provided with a substrate conducive to axonal growth, such as a peripheral nerve graft, many central neurons are able to regenerate axons over long distances. Over the past year this response has been utilised in experimental models to produce a degree of behavioural recovery.
Brecknell
J E
JE
Physiological Laboratory, Cambridge, UK.
Fawcett
J W
JW
D000818:Animals; D001253:Astrocytes / Q000502:physiology; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000502:physiology; D009416:Nerve Regeneration; D009836:Oligodendroglia / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology*; D012583:Schwann Cells / Q000502:physiology