title: Immune response to synthetic materials. Sensitization of patients receiving orthopaedic implants.
abstract: Metallic orthopaedic devices are composed of elements that are known to be skin sensitizers in the general population. There is concern about the possibility of sensitivity reactions in patients bearing these implants. Blood samples were drawn from 22 patients having primary total joint replacement and who had no known prior metal allergies or exposure. Repeat blood samples were drawn 3 months to 1 year later. All preoperative blood samples showed no immune reactions against titanium, cobalt, chromium, or nickel ion solutions in a leukocyte migration inhibition test. Thirty two percent (7 of 22) of the patients developed sensitivity to at least 1 of the antigens, but only 5 percent (1 of 22) developed a severe reaction. Review of the literature and these studies has indicated that such reactions can occur. However, the incidence seems to be very low.
authors.forename: K
authors.initials: K
authors.lastname: Merritt
authors.forename: J J
authors.initials: JJ
authors.lastname: Rodrigo
mesh_terms: D005549:Foreign-Body Reaction / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007111:Immunity, Cellular; D007595:Joint Prosthesis; D008670:Metals; D019736:Prostheses and Implants
chemical_list: D008670:Metals