Structural evidence for functional domains in the rat hippocampus.
The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.
Risold
P Y
PY
Program in Neural, Informational, and Behavioral Sciences, University of Southern California, Los Angeles 90089-2520, USA.
Swanson
L W
LW
D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal; D001931:Brain Mapping; D004745:Enkephalins / Q000032:analysis; D005968:Glutamate Decarboxylase / Q000032:analysis; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology*; D007031:Hypothalamus / Q000033:anatomy & histology / Q000502:physiology; D017403:In Situ Hybridization; D008568:Memory / Q000502:physiology; D009434:Neural Pathways; D009479:Neuropeptides / Q000032:analysis; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology; D051381:Rats; D012686:Septal Nuclei / Q000033:anatomy & histology* / Q000502:physiology*; D013004:Somatostatin / Q000032:analysis; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D004745:Enkephalins; D009479:Neuropeptides; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase