K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities.
Capsular polysaccharide antigens isolated from Klebsiella pneumoniae sero-type 1 (K1) and sero-type 3 (K3) could induce tumor necrosis factor-alpha in ICR mice. K1 and K3 capsular antigens were found to be non-toxic by brine shrimp bioassay. When injected into Ehrlich ascites tumor-bearing mice, both K1 and K3 capsular antigens exhibited significant suppression in the growth of tumor cells. The significance of these observations is discussed.
Choy
Y M
YM
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong.
Tsang
S F
SF
Kong
S K
SK
Leung
K N
KN
Parolis
H
H
Lee
C Y
CY
Fung
K P
KP
D000818:Animals; D000942:Antigens, Bacterial / Q000494:pharmacology*; D001156:Artemia; D016667:Bacterial Capsules; D001599:Berberine / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division / Q000187:drug effects; D006626:Hippurates / Q000633:toxicity; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000942:Antigens, Bacterial; D006626:Hippurates; D011135:Polysaccharides, Bacterial; D014409:Tumor Necrosis Factor-alpha; C036962:capsular polysaccharide K1; C098418:capsular polysaccharide K3; D001599:Berberine; C030514:hippuric acid