title: Gamete and immune cell recognition revisited.
abstract: Fertilization is the result of a series of successful recognition and binding events mediated by gamete surface molecules. Recent advances in the identification and characterization of some of these recognition molecules provide extremely valuable information necessary to understand sperm-egg recognition and subsequent egg activation. We discuss these new data in the context of the model of gamete recognition first proposed by F.R. Lillie in the early part of the 20th century, and revisited periodically in the subsequent literature, which relates fertilization events to those of immune cell recognition and activation events. Here we discuss the principles underlying the molecular recognition and activation mechanisms of gametes and immune cells.
authors.affiliation: Department of Biological Sciences, University of California, Santa Barbara 93106, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Belton
authors.forename: K R
authors.initials: KR
authors.lastname: Foltz
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D005260:Female; D008213:Lymphocyte Activation; D008297:Male; D013084:Sperm-Ovum Interactions; D013601:T-Lymphocytes / Q000276:immunology*