title: Hemodynamic effects of intravenous ephedrine in infants and children anesthetized with halothane and nitrous oxide.
abstract: The aim of this study was to evaluate the effect of age on the hemodynamic responses to intravenous (IV) ephedrine in pediatric patients anesthetized with halothane, nitrous oxide, and oxygen. One hundred ten pediatric patients, ranging in age from 0.1 to 15 yr, were assigned to receive 0.1 mg/kg (n = 55) or 0.2 mg/kg (n = 55) IV ephedrine. General anesthesia was maintained with 1.0 minimum alveolar anesthetic concentration (MAC) of halothane and 67% nitrous oxide in oxygen after tracheal intubation. Measurements of arterial blood pressure and heart rate were made at 1-min intervals for 10 min after ephedrine 0.1 or 0.2 mg/kg was injected IV as a bolus. Significant correlations were noted between age and changes in mean blood pressure (r = 0.37, P < 0.01 for the subjects receiving ephedrine 0.1 mg/kg; r = 0.63, P < 0.001 for the subjects receiving ephedrine 0.2 mg/kg), but not between age and changes in heart rate. The present results indicate that age correlates with the pressor but not the chronotropic effects of ephedrine in pediatric patients anesthetized with 1 MAC halothane and nitrous oxide.
authors.affiliation: Department of Anesthesiology, University of Tsukuba, Ibaraki, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Taguchi
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: S
authors.initials: S
authors.lastname: Inomata
authors.forename: M
authors.initials: M
authors.lastname: Taguchi
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Naito
mesh_terms: D000293:Adolescent; D000322:Adrenergic Agonists / Q000627:therapeutic use*; D000375:Aging; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004809:Ephedrine / Q000627:therapeutic use*; D005260:Female; D006221:Halothane / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D009609:Nitrous Oxide / Q000008:administration & dosage*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D000322:Adrenergic Agonists; D018685:Anesthetics, Inhalation; D014662:Vasoconstrictor Agents; D004809:Ephedrine; D009609:Nitrous Oxide; D006221:Halothane