Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi.
Individual variability in circadian locomotor activity has recently discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Thr-Gly segment, affects in circadian rhythm.
Ben-Shlomo
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Institute of Evolution, University of Haifa, Israel.
Ritte
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Nevo
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D000818:Animals; D001921:Brain / Q000378:metabolism*; D002940:Circadian Rhythm / Q000235:genetics*; D015342:DNA Probes; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D008297:Male; D009043:Motor Activity / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D056950:Period Circadian Proteins; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012377:Rodentia / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013045:Species Specificity
D015342:DNA Probes; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins