title: The nuclear response to cAMP: role of transcription factor CREM.
abstract: In eukaryotes, transcriptional regulation upon stimulation of the adenylate cyclase signalling pathway is mediated by a family of cAMP-responsive nuclear factors. This family consists of a large number of members which may act as activators or repressors. These factors contain the basic domain/leucine zipper motifs and bind as dimers to cAMP-response elements (CRE). The function of CRE-binding proteins is modulated by phosphorylation by several kinases. The ICER (inducible cAMP early repressor) protein is the only inducible member of this family. The induction of this powerful repressor is likely to be important for the transient nature of cAMP-induced gene expression. CRE-binding proteins have been found to play an important role in the physiology of the pituitary gland, in regulating spermatogenesis, in the response to circadian rhythms and in the molecular basis of memory.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
authors.forename: E
authors.initials: E
authors.lastname: Lalli
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Lamas
authors.forename: K
authors.initials: K
authors.lastname: Tamai
authors.forename: E
authors.initials: E
authors.lastname: Zazopoulos
authors.forename: F
authors.initials: F
authors.lastname: Nantel
authors.forename: L
authors.initials: L
authors.lastname: Penna
authors.forename: N S
authors.initials: NS
authors.lastname: Foulkes
authors.forename: P
authors.initials: P
authors.lastname: Sassone-Corsi
mesh_terms: D000595:Amino Acid Sequence; D002467:Cell Nucleus / Q000235:genetics*; D000242:Cyclic AMP / Q000502:physiology*; D051786:Cyclic AMP Response Element Modulator; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D014157:Transcription Factors / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D051786:Cyclic AMP Response Element Modulator; D000242:Cyclic AMP