title: Prevention of vascular graft infection by sisomicin incorporated into fibrin glue.
abstract: To examine the efficacy of sisomicin (SISO) incorporated into fibrin glue (FG) for the prevention of graft infection in animal models, the susceptibility to infection of Dacron grafts (control) and SISO-FG Dacron grafts following the inoculation of Staphylococcus aureus or S. epidermidis was compared. The results showed that SISO-FG Dacron grafts displayed resistance to graft infection.
authors.affiliation: Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamura
authors.forename: T
authors.initials: T
authors.lastname: Sakurai
authors.forename: K
authors.initials: K
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Nabeshima
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis / Q000009:adverse effects / Q000379:methods*; D015169:Colony Count, Microbial; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D051381:Rats; D012853:Sisomicin / Q000008:administration & dosage / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis
chemical_list: D015718:Fibrin Tissue Adhesive; D012853:Sisomicin