title: Preoperative disseminated intravascular coagulation (DIC) associated with aortic aneurysm--does it need to be corrected before surgery?
abstract: Disseminated intravascular coagulation (DIC) is one of the complications accompanying aortic aneurysm. We herein report four patients with aortic aneurysm who had DIC preoperatively. In all four cases, DIC was corrected immediately after surgery; however, in two cases, DIC could not be corrected preoperatively. This prompted us to reconsider the importance of correcting DIC before surgery. Of the four cases reported in this paper, DIC existed even at the time of surgery in two cases, in spite of meticulous treatment with heparin and/or protease inhibitor; however, the DIC could be removed postoperatively even in these two cases. Surgeons should not waste time with intensive DIC treatment preoperatively. If the DIC cannot be corrected within more than 2 weeks of meticulous treatment, surgeons should then perform surgery on the patient. In addition, it is also essential to ensure that the DIC is due to the aneurysm itself and that no other disease processes have been overlooked.
authors.affiliation: Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Oba
authors.forename: N
authors.initials: N
authors.lastname: Shiiya
authors.forename: Y
authors.initials: Y
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Goda
authors.forename: M
authors.initials: M
authors.lastname: Sakuma
authors.forename: K
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000097:blood / Q000150:complications / Q000601:surgery; D000925:Anticoagulants / Q000008:administration & dosage*; D001014:Aortic Aneurysm / Q000097:blood / Q000150:complications / Q000601:surgery*; D001780:Blood Coagulation Tests; D001807:Blood Vessel Prosthesis; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000601:surgery*; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy; D011292:Premedication; D011480:Protease Inhibitors / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D011480:Protease Inhibitors; D006493:Heparin