title: Smooth-muscle physiology.
abstract: In the last several years, significant advances have been made in the understanding of bladder smooth muscle physiology. This article provides a summary for the clinician of current knowledge about the detrusor smooth muscle cell structure, function, and the relationship of structure to function in terms of bladder storage and physical properties such as compliance. The integration of this basic science knowledge into clinical practice is illustrated in discussion of two common disorders: detrusor instability, and outflow obstruction.
authors.affiliation: Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Zimmern
authors.forename: V K
authors.initials: VK
authors.lastname: Lin
authors.forename: J D
authors.initials: JD
authors.lastname: McConnell
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology; D006801:Humans; D009130:Muscle, Smooth / Q000502:physiology*; D009219:Myosin-Light-Chain Kinase / Q000502:physiology; D009218:Myosins / Q000502:physiology; D011817:Rabbits; D014521:Urethra / Q000502:physiology; D001743:Urinary Bladder / Q000502:physiology*; D001748:Urinary Bladder Neck Obstruction / Q000503:physiopathology; D014554:Urination / Q000502:physiology*; D014563:Urodynamics / Q000502:physiology
chemical_list: D009219:Myosin-Light-Chain Kinase; D009218:Myosins; D002118:Calcium