title: Laboratory evaluation of pediatric bone and soft-tissue tumors.
abstract: This article discusses how specimens are approached and handled by the laboratory. Basic histology is reviewed. Contributions by electron microscopy and immunoperoxidase staining are briefly discussed. Current uses of DNA indices, cytogenetic analysis, and new molecular diagnostic advances are highlighted. Proper communication between the pathologist and the orthopedist is the cornerstone for optimal use of laboratory resources.
authors.affiliation: Department of Pathology and Pediatrics, Louisiana State University Medical Center, New Orleans Children's Hospital, Louisiana 70112-1393, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Craver
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D002648:Child; D003582:Cytogenetics; D006801:Humans; D007124:Immunoenzyme Techniques; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology