title: Characteristics of the dysarthria of multiple system atrophy.
abstract: OBJECTIVE
  To characterize the dysarthria in patients with multiple system atrophy (MSA).
  
  
  METHODS
  Motor speech examinations, consisting of oral motor, oral agility, and perceptual speech analysis, were performed on 46 patients with MSA.
  
  
  METHODS
  University department of neurology referral center.
  
  
  RESULTS
  All patients had dysarthria with combinations of hypokinesia, ataxia, or spasticity. Thirty-two patients had all 3 components, 13 had 2 components, and 1 had only 1 component. In most patients the hypokinetic components were the most severe. Hypokinetic components predominated in 22 patients (48%), whereas ataxic components predominated in 16 (35%), and spastic components in 5 (11%). In 1 patient (2%) the hypokinetic and spastic components were equal and greater than the ataxic components, and in 1 patient (2%) the hypokinetic and ataxic components were equal and greater than the spastic components. One patient (2%) had only ataxic dysarthria. The predominant type of dysarthria corresponded well to the subtype of MSA.
  
  
  CONCLUSIONS
  The finding of a mixed dysarthria with combinations of hypokinetic, ataxic, and spastic components is consistent with both the overall clinical and the neuropathologic changes in MSA. Motor speech examination can provide helpful information in evaluating patients who might have MSA.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Kluin
authors.forename: S
authors.initials: S
authors.lastname: Gilman
authors.forename: M
authors.initials: M
authors.lastname: Lohman
authors.forename: L
authors.initials: L
authors.lastname: Junck
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004401:Dysarthria / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009849:Olivopontocerebellar Atrophies / Q000175:diagnosis* / Q000503:physiopathology; D013061:Speech Acoustics; D013068:Speech Production Measurement