Effects of short-term occupational exposure to lead on erythrocyte glucose-6-phosphate dehydrogenase activity and serum cholesterol.
The effect of short-term occupational exposure to lead on erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity and serum cholesterol was studied in 40 male workers of a lead and zinc foundry. All parameters were measured just before employment and after 172 +/- 21.3 days of work. Genetic deficiency of erythrocyte G6PD was observed in 5/40 subjects. Among G6PD normal subjects, increases in enzyme activity followed any change (increase or decrease) in blood lead. At the pre-employment test, serum cholesterol parameters did not show any correlation with GOD activity or blood lead, and they were not affected by exposure. Cholesterol values observed among all the GOD-deficient subjects were within the range of the rest of the study population.
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Istituto di Medicina del Lavoro, Università di Cagliari, Italy.
Salis
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Anni
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Cocco
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ME
Flore
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Ibba
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D000328:Adult; D002784:Cholesterol / Q000097:blood*; D015331:Cohort Studies; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007558:Italy; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D007855:Lead Poisoning / Q000378:metabolism*; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D013054:Spectrophotometry, Atomic
D006454:Hemoglobins; D007854:Lead; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase