Translocation t(8;22) and monosomy 7 in a case of acute lymphoblastic leukemia expressing myeloid markers.
The simultaneous coexpression of lymphoid and myeloid markers has been observed in some cases of childhood acute lymphoblastic leukemias (ALL). In this paper, we describe a 6-year-old male patient with an ALL expressing myeloid antigens in whom a novel karyotypic association, t(8;22) and monosomy 7, and high Ag-NOR activity were found concomitantly with a very short survival.
Pedrazzini
E
E
Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Buenos Aires, Argentina.
Goldztein
S C
SC
Shilton
G
G
Slavutsky
I
I
D014408:Biomarkers, Tumor; D002648:Child; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D008297:Male; D009006:Monosomy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor