Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro.
The antibacterial effects of omeprazole (100, 200 and 300 mg/L) were assessed using bacterial growth curves. A dose-related permanent inhibition was seen with actively growing Gram-positive cocci. A reduced and only temporary effect was observed with Gram-negative bacilli. After 1 day the bacterial count of Helicobacter pylori in the presence of omeprazole 200 mg/L was reduced from 10(4) cfu/mL for the control to zero. No synergic or antagonistic interaction of omeprazole with amoxycillin or doxycycline was observed for Escherichia coli and Enterococcus faecalis.
Jonkers
D
D
Department of Gastroenterology, University of Limburg, The Netherlands.
Stobberingh
E
E
Stockbrügger
R
R
D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016480:Helicobacter pylori / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D009853:Omeprazole