Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis.
Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), children (n = 45), and adults (n = 20), as well as in 51 patients with juvenile chronic arthritis (JCA) of pauciarticular (n = 34), polyarticular (n = 8), or systemic onset type (n = 9). RESULTS. The frequency of positive sera was significantly lower in children than in cord blood and adults as were the levels of aAb-IL-1 alpha (p < 0.0001). In the non-neonatal group of individuals the levels of aAb-IL-1 alpha correlated positively with age (r = 0.394, p = 0.0015). The frequency of sera positive for aAb-IL-1 alpha was higher in the JCA patients, as were the levels (p < 0.005), and correlated positively with disease activity as evaluated by joint score and visual analogue score.
Müller
K
K
Department of Pediatrics, Copenhagen, Denmark.
Hansen
M B
MB
Zak
M
M
Nielsen
S
S
Pedersen
F K
FK
de Nully
P
P
Bendtzen
K
K
D000328:Adult; D000367:Age Factors; D001171:Arthritis, Juvenile / Q000097:blood / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D008297:Male
D001323:Autoantibodies; D007375:Interleukin-1