title: [The effect of intravenous ascorbic acid on urinary 17-hydroxysteroid excretion at an early stage of cerebral stroke].
abstract: The main symptoms of stroke such as a displacement of intracranial structures, changes in spatial relations, secondary hemorrhagic and ischemic foci, oedema and metabolic disturbances are the cause of the disorders of hypothalamus-hypophysis system leading to increased secretion of corticosteroids including 17-hydroxyketosteroids (17-OHKS). Steroidogenesis in inhibited by high concentrations of ascorbic acid. Intravenous injections of ascorbic acid 0.5 g were given to the patients with stroke and their urine was analysed daily to examine the secretion of 17-OHKS. A slight increase in 17-OHKS secretion was found on 1 and 2 days of the disease in patients suffering from TIA and a significant increase in 17-OHKS secretion was detected in patients with cerebral ischaemia (ischemic stroke) and cerebral hemorrhage and persisted for 3-4 days of the illness. One can presume that the disorders of hypothalamus-hypophysis-adrenal system contributes much more to the decrease in 17 OHKS secretion on successive days of stroke than the administration of ascorbic acid.
authors.affiliation: Oddziału Neurologii Wojewódzkiego Szpitala Zespolonego w Radomiu.
authors.forename: K
authors.initials: K
authors.lastname: Nadgrodkiewicz
mesh_terms: D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006914:Hydroxysteroids / Q000378:metabolism* / Q000652:urine*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007275:Injections, Intravenous; D002546:Ischemic Attack, Transient / Q000503:physiopathology / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology
chemical_list: D006914:Hydroxysteroids; D001205:Ascorbic Acid
vernacular_title: Wpływ dozylnego podawania kwasu askorbinowego na wydalanie 17-hydroksysterydów w moczu u chorych z udarem mózgu we wczesnym okresie choroby.