title: Incidence of urethral tumor involvement in 910 men with bladder cancer.
abstract: Urethral tumor involvement was examined in 910 patients treated for bladder cancer at a single institution over a period of 25 years. The overall incidence in 2,052 primary and recurrent bladder-tumor events was 6.1%. Risk factors for urethral tumor occurrence are tumors at the bladder neck and recurrent multifocal tumors. Carcinoma in situ (CIS) of the bladder not involving the bladder neck and muscle-invasive tumors with or without lymph-node involvement are not significantly correlated with urethral cancer. Patients at risk for urethral tumors as outlined should be worked up very carefully (multiple urethral biopsies and/or urethral brushings, frozen section of the membranous urethra) before they are considered for an orthotopic neobladder. Altogether, 17 of 89 patients had 1-6 urethral tumor recurrences. The majority of urethral tumors were treated with a single conservative treatment session and did not recur thereafter. A conservative approach toward superficial urethral tumor recurrences in patients with an orthotopic neobladder to the urethra may therefore be feasible.
authors.affiliation: Department of Urology, University Clinic of Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Erckert
authors.forename: A
authors.initials: A
authors.lastname: Stenzl
authors.forename: M
authors.initials: M
authors.lastname: Falk
authors.forename: G
authors.initials: G
authors.lastname: Bartsch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012008:Recurrence; D012189:Retrospective Studies; D014523:Urethral Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000473:pathology