title: Preliminary results for positron emission mammography: real-time functional breast imaging in a conventional mammography gantry.
abstract: In order to optimally integrate radiotracer breast imaging within the breast clinic, anatomy and pathology should be easily correlated with functional nuclear medicine breast images. As a first step in the development of a hybrid functional/anatomic breast imaging platform with biopsy capability, a conventional X-ray mammography gantry was modified to image the compressed breast with positron emitters. Phantom studies with the positron emission mammography (PEM) device showed that a 1-cc hot spot could be detected within 5 min. A preliminary clinical trial demonstrated in vivo visualization of primary breast cancer within 4 min. For sites where positron-emitting radionuclides are available, PEM promises to achieve low-cost directed functional examination of breast abnormalities, with the potential for achieving X-ray correlation and image-guided biopsy.
authors.affiliation: National Institutes of Health, Bethesda, USA.
authors.forename: I
authors.initials: I
authors.lastname: Weinberg
authors.forename: S
authors.initials: S
authors.lastname: Majewski
authors.forename: A
authors.initials: A
authors.lastname: Weisenberger
authors.forename: A
authors.initials: A
authors.lastname: Markowitz
authors.forename: L
authors.initials: L
authors.lastname: Aloj
authors.forename: L
authors.initials: L
authors.lastname: Majewski
authors.forename: D
authors.initials: D
authors.lastname: Danforth
authors.forename: J
authors.initials: J
authors.lastname: Mulshine
authors.forename: K
authors.initials: K
authors.lastname: Cowan
authors.forename: J
authors.initials: J
authors.lastname: Zujewski
authors.forename: C
authors.initials: C
authors.lastname: Chow
authors.forename: E
authors.initials: E
authors.lastname: Jones
authors.forename: V
authors.initials: V
authors.lastname: Chang
authors.forename: W
authors.initials: W
authors.lastname: Berg
authors.forename: J
authors.initials: J
authors.lastname: Frank
mesh_terms: D001940:Breast / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008327:Mammography / Q000295:instrumentation; D008875:Middle Aged; D019047:Phantoms, Imaging; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose