Sex chromosome abnormalities in lung cancer patients.
Chromosomal analyses of lymphocytes from lung cancer patients and normal subjects revealed that the X and the Y chromosomes have both structural and numerical abnormalities in higher frequency in patients compared to the controls. These abnormalities included chromatid/isochromatid breaks, translocations, ring formation, and selective nondisjunctions, resulting in multisomies of either the X or Y chromosomes. Possible significance of these genetic abnormalities are discussed in relation to lung cancer patients.
Dave
B J
BJ
Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Hopwood
V L
VL
Spitz
M R
MR
Pathak
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014960:X Chromosome; D014998:Y Chromosome