The role of arginine vasopressin in interleukin-1 beta-induced adrenocorticotropin secretion in the rat.
In this study we examined whether arginine vasopressin (AVP) in the brain is involved in the adrenocorticotropin (ACTH) secretion induced by interleukin (IL)-1 beta in the rat. Human recombinant IL-1 beta (50 ng) was given intracerebroventricularly to freely moving male rats with or without a prior (15 min before) administration of anticorticotropin releasing hormone (CRH) or AVP antibody via the same route. The ACTH response to IL-1 beta was significantly reduced by both anti-CRH and anti-AVP antisera compared to the levels after normal rabbit serum. These results suggest that not only CRH but also AVP may mediate the IL-1 beta stimulation of ACTH secretion in the rat.
Sasaki
S
S
Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
Watanobe
H
H
Takebe
K
K
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007106:Immune Sera / Q000494:pharmacology; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology
D007106:Immune Sera; D007375:Interleukin-1; D011994:Recombinant Proteins; D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone