title: Use of radionuclide imaging to determine gastric emptying of carbohydrate solutions during exercise.
abstract: OBJECTIVE
  To investigate the repeatability of continual assessment of the gastric emptying rates of carbohydrate solutions in exercising subjects using 99mtechnetium labelling.
  
  
  METHODS
  Gastric emptying of a 5% glucose solution and an iso-osmotic maltodextrin solution was measured using 3 MBq of 99mtechnetium labelled diethylene triamine penta-acetic acid (DTPA) and continuous gamma camera imaging in five male subjects. The subjects performed four 1 h trials at 70% VO2 peak on a cycle ergometer. After 15 min, 200 ml of a radiolabelled solution of glucose or maltodextrin were ingested in a blind crossover protocol. The two solutions were each ingested on separate occasions (trial 1 and trial 2) to establish repeatability.
  
  
  RESULTS
  Statistical analysis showed no differences between trial 1 and trial 2 for both solutions. There were no significant differences for the emptying rates between the two test solutions.
  
  
  CONCLUSIONS
  Posterior imaging using a computer linked gamma camera following the ingestion of 99mtechnetium labelled DTPA mixed with carbohydrate solutions provides a repeatable method of assessing gastric emptying characteristics in exercising subjects. This technique showed no significant differences between the emptying rates of a single dose of iso-osmotic glucose or maltodextrin solution.
authors.affiliation: School of Human Sciences, Liverpool John Moores University, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: MacLaren
authors.forename: A
authors.initials: A
authors.lastname: Miles
authors.forename: I
authors.initials: I
authors.lastname: O'Neill
authors.forename: M
authors.initials: M
authors.lastname: Critchley
authors.forename: S
authors.initials: S
authors.lastname: Grime
authors.forename: H
authors.initials: H
authors.lastname: Stockdale
mesh_terms: D000328:Adult; D001628:Beverages; D015444:Exercise / Q000502:physiology*; D005746:Gastric Emptying; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D008320:Maltose; D008991:Monitoring, Physiologic / Q000379:methods*; D004369:Pentetic Acid; D011134:Polysaccharides; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging*; D013667:Technetium
chemical_list: D007552:Isotonic Solutions; D011134:Polysaccharides; D008320:Maltose; D013667:Technetium; D004369:Pentetic Acid; C008315:maltodextrin