Behavioral effects of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome).
The behavioral effects of felbamate were assessed in 20 persons, (ages 2 to 19 years) who were participating in a compassionate plea protocol for children with Lennox-Gastaut syndrome. Parents completed a questionnaire concerning aspects of behavioral change once all medications were in a constant regimen. Significant improvements were suggested in social functioning, intellectual functioning, motor functioning, attention and concentration, alertness, initiative, variability in performance, and memory. There was a tendency for these effects to reverse when the drug was discontinued.
Gay
P E
PE
Department of Psychology, Westminster College, Salt Lake City, Utah 84106, USA.
Mecham
G F
GF
Coskey
J S
JS
Sadler
T
T
Thompson
J A
JA
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D001925:Brain Damage, Chronic / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy* / Q000523:psychology; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology; D000078328:Felbamate; D005260:Female; D006801:Humans; D008297:Male; D010552:Personality Assessment; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000009:adverse effects / Q000627:therapeutic use*; D012919:Social Behavior; D013577:Syndrome
D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate