title: Large granular lymphocyte leukemia associated with hepatocellular carcinoma: a case report.
abstract: The association of large granular lymphocyte leukemia (LGL-L) with hepatocellular carcinoma in a 55-year-old patient is described. An increased number of LGL was seen on peripheral blood smears. The immunophenotype was CD3+, CD4-, CD8+, and a study of the TCR gene rearrangement indicated the monoclonal nature of the proliferation. A liver mass was detected on CT scan and an ultrasound-guided fine needle biopsy revealed the presence of hepatocholangiocellular elements. A right hepatectomy was performed. Major neutropenia persisted despite corticosteroids and granulocyte colony-stimulating growth factor (G-CSF) therapy. Methotrexate at 20 mg/week failed to control lymphocytosis after three months of treatment. A new nodule of hepatocarcinoma reappeared twelve months after surgery and a liver resection was performed.
authors.affiliation: Clinica Chirurgica, Università degli Studi di Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Borgonovo
authors.forename: V
authors.initials: V
authors.lastname: Secondo
authors.forename: E
authors.initials: E
authors.lastname: Varaldo
authors.forename: V
authors.initials: V
authors.lastname: Pistoia
authors.forename: M
authors.initials: M
authors.lastname: Gobbi
authors.forename: F P
authors.initials: FP
authors.lastname: Mattioli
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications*; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications*; D008875:Middle Aged