title: Chemistry of pseudomonic acid. Part 16. Aryl and heteroaryl ketone derivatives of monic acid.
abstract: The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth, Surrey, UK.
authors.forename: A
authors.initials: A
authors.lastname: Abson
authors.forename: N J
authors.initials: NJ
authors.lastname: Broom
authors.forename: P A
authors.initials: PA
authors.lastname: Coates
authors.forename: J S
authors.initials: JS
authors.lastname: Elder
authors.forename: A K
authors.initials: AK
authors.lastname: Forrest
authors.forename: P C
authors.initials: PC
authors.lastname: Hannan
authors.forename: A J
authors.initials: AJ
authors.lastname: Hicks
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Hanlon
authors.forename: N D
authors.initials: ND
authors.lastname: Masson
authors.forename: N D
authors.initials: ND
authors.lastname: Pearson
authors.forename: J E
authors.initials: JE
authors.lastname: Pons
authors.forename: J M
authors.initials: JM
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007659:Ketones / Q000737:chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D018805:Sepsis / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D007659:Ketones; D013844:Thiazoles; D016712:Mupirocin