title: A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere.
abstract: A contiguous physical map was constructed from the Harvey ras-1 (HRAS1) gene to the 11p telomere. The contig spans approximately 500 kb and is minimally composed of a telomere-containing YAC and P1 and cosmid clones. Included in the contig are 11 sequence-tagged sites derived from P1 and cosmid ends. Three genes were placed on the contig in the following order: telomere-ribonuclease/angiogenin inhibitor (RNH)-Harvey ras-1 (HRAS1)-HRAS1-related complex (HRC). Two novel tetranucleotide repeats (heterozygosity of 66 and 68%) and a complex CA repeat (heterozygosity of 78%) were isolated and characterized.
authors.affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, 48109, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Russell
authors.forename: D J
authors.initials: DJ
authors.lastname: Munroe
authors.forename: E
authors.initials: E
authors.lastname: Bric
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
authors.forename: J
authors.initials: J
authors.lastname: Dietz-Band
authors.forename: H C
authors.initials: HC
authors.lastname: Riethman
authors.forename: F S
authors.initials: FS
authors.lastname: Collins
authors.forename: L C
authors.initials: LC
authors.lastname: Brody
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002880:Chromosomes, Human, Pair 11; D018900:Dinucleotide Repeats; D011905:Genes, ras; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D019105:Random Amplified Polymorphic DNA Technique; D016615:Telomere
chemical_list: D005819:Genetic Markers