Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.
To define the role of interleukin (IL)6 in Candida albicans infection, IL-6 deficient mice were assessed for susceptibility to systemic or gastrointestinal infection, as well as for parameters of elicited T helper cell (Th) immunity. IL-6-deficient mice were more susceptible than wild-type mice to either type of infection caused by virulent C. albicans. In response to systemic challenge with a live vaccine strain of yeast, IL-6-deficient mice failed to mount Th1-associated protective immunity, but the resulting Th2-biased response could be redirected to the Th1 phenotype by IL-10 neutralization. Severe impairment of the macrophage and neutrophil response to infection was observed in IL-6-deficient mice, but administration of IL-6 would increase both neutrophil response and resistance to infection. IL-6 seems to oppose the Th2-promoting role of IL-10 in candidiasis, its early regulatory activity involving effects on neutrophil function.
Romani
L
L
Microbiology Section, Department of Experimental Medicine and Biomedical Sciences, University of Perugia, Italy.
Mencacci
A
A
Cenci
E
E
Spaccapelo
R
R
Toniatti
C
C
Puccetti
P
P
Bistoni
F
F
Poli
V
V
D000818:Animals; D002176:Candida albicans / Q000472:pathogenicity; D002177:Candidiasis / Q000276:immunology*; D016207:Cytokines / Q000097:blood; D004198:Disease Susceptibility; D005260:Female; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000172:deficiency* / Q000494:pharmacology; D007668:Kidney / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D009500:Neutralization Tests; D009504:Neutrophils / Q000276:immunology*; D013270:Stomach / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines; D015850:Interleukin-6; D016753:Interleukin-10