Antibodies to four gram-negative bacteria in rheumatoid arthritis which share sequences with the rheumatoid arthritis susceptibility motif.
The bacteria Proteus, Serratia, Escherichia and Pseudomonas possess sequences resembling the rheumatoid arthritis susceptibility sequence EQRRAA, but antibodies were elevated only to Proteus in 66 RA patients (P<0.001) when compared to 61 active ankylosing spondylitis patients and 60 controls.
Tiwana
H
H
Division of Life Sciences, King's College, London.
Wilson
C
C
Cunningham
P
P
Binder
A
A
Ebringer
A
A
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006092:Gram-Negative Facultatively Anaerobic Rods / Q000235:genetics / Q000276:immunology*; D006684:HLA-DR Antigens; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011511:Proteus / Q000276:immunology; D011513:Proteus mirabilis / Q000276:immunology; D017386:Sequence Homology, Amino Acid; D012706:Serratia marcescens / Q000276:immunology
D000907:Antibodies, Bacterial; D006684:HLA-DR Antigens; D007136:Immunoglobulins