The POU factor Oct-6 and Schwann cell differentiation.
The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.
Jaegle
M
M
Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands.
Mandemakers
W
W
Broos
L
L
Zwart
R
R
Karis
A
A
Visser
P
P
Grosveld
F
F
Meijer
D
D
D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000648:ultrastructure; D001483:Base Sequence; D002454:Cell Differentiation; D015870:Gene Expression; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D018993:Myelin P0 Protein / Q000235:genetics / Q000378:metabolism; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology; D050816:Octamer Transcription Factor-6; D011995:Recombination, Genetic; D012583:Schwann Cells / Q000166:cytology* / Q000502:physiology; D012584:Sciatic Nerve / Q000166:cytology / Q000254:growth & development; D013234:Stem Cells; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*
D018993:Myelin P0 Protein; D009185:Myelin Proteins; C494180:Pou3f1 protein, mouse; D014157:Transcription Factors; D050816:Octamer Transcription Factor-6