[Effect of extreme conditions on succinate oxidation in rat brain mitochondria].
Emergencies which were different in origin, but identical in the magnitude of pathogenic action on the brain, such as 3.5-hour cerebral circulatory ischemia found 49-hour restriction stress, induced the the same brain mitochondrial responses in Wistar rats. Two types of responses in organelles were identified: (1) that wherein there were lower succinate oxidation rates than those in the control (sham = operated and intact animals) and diverted effects on succinate dehydrogenase activators; (2) that wherein there was accelerated succinate oxidation and persisted stimulating effects of enzyme activators. A relationship was shown between the type of responses and the degree of succinate dehydrogenase inhibition induced by emergencies.
Poborskiĭ
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Zimina
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D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D013386:Succinates / Q000378:metabolism*; D019802:Succinic Acid
D013386:Succinates; D019802:Succinic Acid
Vliianie nekotorykh ékstremal'nykh vozdeĭstviĭ na okislenie suktsinata v mitokhondriiakh mozga krys.