title: [ACE-inhibitors in acute heart infarct].
abstract: The use of ACE-inhibitors in heart failure has been established over the past years. Their use is of uncertain value in the early phases of myocardial infarction, where they are supposed to prevent left ventricular dilatation. More recent studies (ISIS-4, GISSI-3) have tested early treatment by ACE-inhibitors in the acute phase of myocardial infarction. On one hand, it was possible to disprove reservations about risks (hypotension)n in a large cohort; on the other hand, a further reduction of mortality in hospitalized patients by 7% has been shown, corresponding to five patient lives saved for 1000 treated patients. Thus, after institution of the customary therapy of myocardial infarction (inhibitor of platelet aggregation, thrombolysis, beta-blocker) and after exclusion of specific contraindications (hypotension < 100 mmHg, renal failure) ACE-inhibitors could be administered in the acute phase of myocardial infarction. An analysis of the results from these large trials will show whether ACE-inhibitors may benefit groups of patients at particular risks (Killip > 1, age > 70 years, preceding renal failure) noticeably. ACE-inhibitors remain the treatment of choice in patients with developing left ventricular failure.
authors.affiliation: ISIS-Studiengruppe Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Genoni
authors.forename: G
authors.initials: G
authors.lastname: Garzoli
authors.forename: M
authors.initials: M
authors.lastname: Pfister
authors.forename: P
authors.initials: P
authors.lastname: Siegrist
authors.forename: R
authors.initials: R
authors.lastname: Malacrida
authors.forename: A
authors.initials: A
authors.lastname: Maggioni
authors.forename: T
authors.initials: T
authors.lastname: Moccetti
mesh_terms: D000208:Acute Disease; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
vernacular_title: ACE-Hemmer beim akuten Herzinfarkt.