Probable exclusion of the cortexin-encoding gene as a candidate for mouse neurological mutants: nervous, tottering and motor neuron degeneration.
We have tested the gene encoding cortexin, Ctxn, which maps to chromosome 8, as a candidate for the mouse neurological mutants: nervous (nr), tottering (tg) plus tottering-leaner (tgla), and motor neuron degeneration (mnd) by Northern blot analysis of brain poly(A)+ RNA and direct polymerase chain reaction (PCR) sequencing. No difference from wild-type was seen in any of these mutants. Based upon these observations, we conclude that Ctxn is not involved in the genetic defects found in nr, tg or mnd mice.
Horvath
D H
DH
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75235-9111, USA.
Watson
J B
JB
Travis
G H
GH
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D001923:Brain Chemistry / Q000235:genetics; D006720:Homozygote; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D008969:Molecular Sequence Data; D016472:Motor Neuron Disease / Q000235:genetics*; D009154:Mutation; D009410:Nerve Degeneration / Q000235:genetics*; D010455:Peptides / Q000235:genetics*; D017354:Point Mutation
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C056590:cortexin