[Prevention of cardiovascular diseases by hormone replacement in postmenopause].
Cardiovascular disease is the most important cause of death even among women. After menopause there is a steep increase in risk factors like LDL-cholesterol and lipoprotein (a) as well as the incidence of hypertension and diabetes mellitus. This is followed by a rise especially in coronary artery disease. Therefore women too have to be included in prevention programs for cardiovascular disease by normalizing risk factors. One means is hormone replacement therapy. Estrogens lower LDL-cholesterol by up to 20% and increase HDL-cholesterol up to 30%. This effect remains even after addition of a suitable progestin. Numerous large scale studies indicate that every other cardiovascular death can be prohibited by the simple measure of hormone replacement therapy. Because of the high rate of cardiovascular disease low incidences of adverse events cannot prevent the marked decrease in total mortality.
Windler
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Medizinische Kernklinik and Poliklinik, Universitäts-Krankenhaus Eppendorf, Hamburg.
D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002979:Climacteric / Q000187:drug effects*; D003327:Coronary Disease / Q000097:blood / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D015996:Survival Rate
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
Prävention kardiovaskulärer Erkrankungen durch Hormonsubstitution in der Postmenopause.