Making DNA add.
Recent studies have demonstrated the feasibility of using DNA-based experiments to compute solutions to combinatorial problems. However, a prerequisite for designing a computer useful in a wide range of applications is the ability to perform mathematical calculations. The development of a DNA-based algorithm for addition is presented. The DNA representation of two nonnegative binary numbers is presented in a form permitting a chain of primer extension reactions to carry out the addition operation. To demonstrate the feasibility of this algorithm, a simple example was executed biochemically.
Guarnieri
F
F
Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Fliss
M
M
Bancroft
C
C
D000465:Algorithms; D001483:Base Sequence; D003201:Computers; D004247:DNA; D008432:Mathematical Computing; D008969:Molecular Sequence Data; D013698:Templates, Genetic
D004247:DNA