Epsilon 4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population.
We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi 2 = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese.
Hong
C J
CJ
Neurological Institute, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Liu
T Y
TY
Liu
H C
HC
Wang
S J
SJ
Fuh
J L
JL
Chi
C W
CW
Lee
K Y
KY
Sim
C B
CB
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D002681:China / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D012306:Risk
D053327:Apolipoprotein E4; D001057:Apolipoproteins E