[Biological role of HLA-C].
Human major histocompatibility complex class I molecules, HLA-A and -B, bind peptides derived from intracellular proteins, transport them to the cell surface and present them to T lymphocytes. Much less is known about the function of the third "classical" class I molecule, HLA-C. Recent data disclosing remarkable polymorphism of HLA-C, possible importance of this molecule for the recognition of target cells by nature killer cells, and capability to present viral antigens to the T lymphocytes are reviewed. Preliminary results from our laboratory on binding of synthesis peptides to HLA-Cw3+ cells are presented.
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Laboratorium Immunogenetyki Zakładu Immunologii Klinicznej.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001483:Base Sequence; D015236:HLA-C Antigens / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism; D011110:Polymorphism, Genetic; D013601:T-Lymphocytes / Q000276:immunology
D000956:Antigens, Viral; D015236:HLA-C Antigens; D010455:Peptides
Biologiczna rola HLA-C.