title: The correlation between protein catabolic rate and Kt/V in hemodialysis is not a mathematical artifact.
abstract: To test whether the demonstrated correlation between Kt/V urea and normalised protein catabolic rate (NPCR) is caused by a mathematical artifact, we examined 12 adult and 8 paediatric haemodialysis patients. Kt/V was determined by the classical method. As an equivalent of NPCR we measured normalised urea generation rate (NUGR) by a one-week collection of dialysate and urine using total body water estimated by bioelectrical impedance for normalisation. The correlation between Kt/V and NUGR was 0.58 (all), 0.55 (adults), and 0.62 (children). Since the determination of Kt/V and NUGR are not interdependent, we conclude that the correlation between Kt/V and protein catabolism is not artifactual.
authors.affiliation: Department of Renal Medicine, St. James University Hospital, Leeds, UK.
authors.forename: T
authors.initials: T
authors.lastname: Buur
authors.forename: S W
authors.initials: SW
authors.lastname: Smye
authors.forename: M
authors.initials: M
authors.lastname: Bradbury
authors.forename: E J
authors.initials: EJ
authors.lastname: Will
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009752:Nutritional Status; D011506:Proteins / Q000493:pharmacokinetics*; D012016:Reference Values; D006435:Renal Dialysis; D014508:Urea / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D011506:Proteins; D014508:Urea