title: Decreased food intake does not completely account for adiposity reduction after ob protein infusion.
abstract: The effects of recombinantly produced ob protein were compared to those of food restriction in normal lean and genetically obese mice. Ob protein infusion into ob/ob mice resulted in large decreases in body and fat-depot weight and food intake that persisted throughout the study. Smaller decreases in body and fat-depot weights were observed in vehicle-treated ob/ob mice that were fed the same amount of food as that consumed by ob protein-treated ob/ob mice (pair feeding). In lean mice, ob protein infusion significantly decreased body and fat-depot weights, while decreasing food intake to a much lesser extent than in ob/ob mice. Pair feeding of lean vehicle-treated mice to the intake of ob protein-treated mice did not reduce body fat-depot weights. The potent weight-, adipose-, and appetite-reducing effects exerted by the ob protein in ob protein-deficient mice (ob/ob) confirm hypotheses generated from early parabiotic studies that suggested the existence of a circulating satiety factor of adipose origin. Pair-feeding studies provide compelling evidence that the ob protein exerts adipose-reducing effects in excess of those induced by reductions in food intake.
authors.affiliation: Department of Pulmonary Research, Genentech, Inc., South San Francisco,CA 94080, USA.
authors.forename: N
authors.initials: N
authors.lastname: Levin
authors.forename: C
authors.initials: C
authors.lastname: Nelson
authors.forename: A
authors.initials: A
authors.lastname: Gurney
authors.forename: R
authors.initials: R
authors.lastname: Vandlen
authors.forename: F
authors.initials: F
authors.lastname: de Sauvage
mesh_terms: D000273:Adipose Tissue; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D002149:Energy Intake; D005260:Female; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D020738:Leptin; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000008:administration & dosage / Q000235:genetics / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008055:Lipids; D011506:Proteins; D011994:Recombinant Proteins