Identification of 14-hydroxy-4,14-retro-retinol as an in vivo metabolite of vitamin A.
Retinol (vitamin A alcohol) undergoes extensive metabolism in vertebrates. We report here (i) the identification of a yet undescribed in vivo metabolite of retinol as 14-hydroxy-4,14-retro-retinol in pregnant mice, rats and rabbits following dosing with vitamin A, and (ii) the preferential accumulation of 14-hydroxy-4,14-retro-retinol in maternal and embryonic tissues, rather than in material plasma.
Tzimas
G
G
Institut für Toxikologie und Embryopharmakologie, Freie Universitat Berlin, Germany.
Collins
M D
MD
Nau
H
H
D000818:Animals; D005260:Female; D006801:Humans; D051379:Mice; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014801:Vitamin A / Q000378:metabolism*
D014801:Vitamin A