Synthesis and antiplatelet activity of 1-tert-butylamino-3-(3-thienyloxy)-2-propanols.
The synthesis of new 1-tert-butylamino-3-(3-thienyloxy)-2-propanols by two alternative methods is described. Their initial antiplatelet activity evaluation against ADP, adrenaline, and collagen is reported, and the preliminary structure-activity relationships are established. The appropriateness of further pharmacological investigations, especially for the best compound of the series 1f, is indicated.
Abdallah
S
S
Deparmento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
Darias
V
V
Donoso
R
R
Jordán de Urríes
P
P
Lissavetzky
J
J
D000433:1-Propanol / Q000138:chemical synthesis / Q000494:pharmacology*; D000328:Adult; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D020005:Propanols; D013329:Structure-Activity Relationship
D010975:Platelet Aggregation Inhibitors; D020005:Propanols; D000433:1-Propanol