title: Synthesis and in vitro antitumor activity evaluation of 9-substituted 1,2,3,4-tetrahydrocarbazoles.
abstract: A series of 9-acetamido-1,2,3,4-tetrahydrocarbazoles (2) and 9-(aminoalkyloxyethyl)-1,2,3,4-tetrahydrocarbazoles (4) were prepared and tested for their in vitro antitumor activity. Compounds 4 are highly cytotoxic in almost all subpanel cell lines when tested at 10(-4) M, but showed a weak activity at the lowest concentrations employed.
authors.affiliation: Dipartimento Farmaco-Chimico - Università di Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: C
authors.initials: C
authors.lastname: Molica
authors.forename: A M
authors.initials: AM
authors.lastname: Monforte
authors.forename: P
authors.initials: P
authors.lastname: Monforte
authors.forename: M
authors.initials: M
authors.lastname: Zappalà
authors.forename: M
authors.initials: M
authors.lastname: Rizzo
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles