Response of Mycobacterium smegmatis to acid stress.
Evidence was sought for the existence of an inducible acid tolerance response in Mycobacterium smegmatis. Exposure of M. smegmatis to a sub-lethal, adaptive acidic pH was found to confer a significant level of protection against subsequent exposure to a lethal pH, compared to unadapted cells. Adaptation was dependent on de novo protein synthesis.
O'Brien
L M
LM
Department of Microbiology and Immunology, University of Leicester, UK.
Gordon
S V
SV
Roberts
I S
IS
Andrew
P W
PW
D000143:Acids / Q000494:pharmacology*; D000222:Adaptation, Physiological / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D009161:Mycobacterium / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
D000143:Acids; D002701:Chloramphenicol