Simple production of [1-carbon-11]acetate.
We report an attractive approach for the preparation of [1-11C]acetate.


METHODS
The procedure involved the instantaneous hydrolysis of [1-11C]acetyl chloride back to [1-11C]acetic acid by simply trapping the volatile acid chloride in physiological saline. This delivered [1-11C]acetate immediately in pharmaceutical quality.


RESULTS
An easy and quantitative gas phase separation of the radiopharmaceutical from any inorganic residue and organic contamination could be achieved. The preparation required a minimum of automation and afforded only 5 min for an amount of 15 GBq of [1-11C]acetate which was yet ready for injection. Multiple preparations could be performed within 1 day.


CONCLUSIONS
The use of [1-11C]acetyl chloride as a precursor to [1-11C]acetate is of considerable practical importance lending itself to automation with ease and giving the target compound directly in sterile solution without the need for further care and purification.
Oberdorfer
F
F
German Cancer Research Center, Heidelberg, Germany.
Theobald
A
A
Prenant
C
C
D000085:Acetates / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D014055:Tomography, Emission-Computed
D000085:Acetates; D002250:Carbon Radioisotopes