title: All-trans-retinoic acid and pseudotumor cerebri in a young adult with acute promyelocytic leukemia: a possible disease association.
abstract: Pseudotumor cerebri or idiopathic intracranial hypertension is a neurological syndrome characterized by signs and symptoms of intracranial hypertension without clinical or radiological evidence of infective or space occupying lesions. Iatrogenic factors are frequent; in particular, cases of pseudotumor cerebri associated with all-trans-retinoic acid treatment in acute promyelocytic leukemia (APL) have been frequently described in pediatric patients. We report on a case observed in an older patient (young adult age) and give diagnostic and therapeutic guidelines.
authors.affiliation: Institute of Hematology L. & A. Seragnoli, University of Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Visani
authors.forename: G
authors.initials: G
authors.lastname: Bontempo
authors.forename: S
authors.initials: S
authors.lastname: Manfroi
authors.forename: A
authors.initials: A
authors.lastname: Pazzaglia
authors.forename: R
authors.initials: R
authors.lastname: D'Alessandro
authors.forename: S
authors.initials: S
authors.lastname: Tura
mesh_terms: D000293:Adolescent; D006801:Humans; D007049:Iatrogenic Disease; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D014212:Tretinoin / Q000009:adverse effects*
chemical_list: D014212:Tretinoin