Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines.
Most of the receptors for soluble factors functioning in the hematopoietic system belong to the class I cytokine receptor family. These receptors often share common signal transducing receptor components in the same family, which explains the functional redundancy of cytokines. One typical example is a group of receptor systems for interleukin-6 (IL-6) and related cytokines that share gp130 as a signal transducer. This subset of cytokines, i.e., IL-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1, are all pleiotropic, exhibiting overlapping biological activities, and are known to function also in the neuronal system. In their receptor complexes, gp130 and ligand-specific chains possess no intrinsic tyrosine kinase domain but are associated with members of the Jak family of cytoplasmic tyrosine kinases. The Jak kinases become activated after ligand-induced homo- or heterodimerization of gp130. This activation appears to link the cell surface receptors to the nuclear genes through a series of biochemical changes, including tyrosine phosphorylation and activation of a latent cytoplasmic transcription factor called signal transducer and activator of transcription 3 (STAT3).
Taga
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Institute for Molecular and Celular Biology, Osaka University, Osaka, Japan.
D015703:Antigens, CD / Q000737:chemistry / Q000502:physiology*; D001773:Blood Cells / Q000737:chemistry / Q000166:cytology; D002454:Cell Differentiation / Q000502:physiology; D050822:Cytokine Receptor gp130; D016207:Cytokines / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D009474:Neurons / Q000737:chemistry / Q000166:cytology; D015398:Signal Transduction / Q000502:physiology*
D015703:Antigens, CD; D016207:Cytokines; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130