Effect of methimazole treatment of maternal thyrotoxicosis on thyroid function in breast-feeding infants.
In 35 infants of lactating mothers with thyrotoxicosis who were receiving 5 to 20 mg methimazole daily, serum levels of thyroxine, triiodothyronine, thyrotropin were within normal ranges 1 month after the start of breast-feeding. Thyroid function in breast-feeding infants of six lactating mothers receiving methimazole, 20 mg for the first, 10 mg for the second, and 5 mg for an additional 4 months, remained normal. These results suggest the safety of methimazole therapy in lactating mothers.
Azizi
F
F
Endocrine Research Centre, University of Medical Sciences, Tehran, Iran.
D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001942:Breast Feeding; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008713:Methimazole / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*; D011644:Puerperal Disorders / Q000097:blood / Q000188:drug therapy*; D013960:Thyroid Function Tests; D013971:Thyrotoxicosis / Q000097:blood / Q000188:drug therapy*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013956:Antithyroid Agents; D014284:Triiodothyronine; D008713:Methimazole; D013972:Thyrotropin; D013974:Thyroxine