Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.
In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.
Detera-Wadleigh
S D
SD
Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA. sevilla@helix.nih.gov
Badner
J A
JA
Goldin
L R
LR
Berrettini
W H
WH
Sanders
A R
AR
Rollins
D Y
DY
Turner
G
G
Moses
T
T
Haerian
H
H
Muniec
D
D
Nurnberger
J I
JI
Gershon
E S
ES
D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D009679:Nuclear Family; D010375:Pedigree; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D018570:Risk Assessment
D005819:Genetic Markers