title: A case of hypergonadotrophinaemia associated with very high isolated concentrations of immunologically and biologically active luteinizing hormone.
abstract: A very rare case of a menstruating infertile woman with isolated luteinizing hormone (LH) hypergonadotrophinaemia is presented. There were no signs indicating the presence of a pituitary microadenoma, and LH had normal bioactivity and normal molecular weight. Likewise, no mutation was detected in the coding region of the LH beta-chain gene. In a non-stimulated cycle and a clomiphene citrate cycle, the patient developed an unruptured cyst. The patient ovulated and conceived twice following the addition of human chorionic gonadotrophin. A partial resistance at the ovarian LH receptor site, perhaps caused by a mutation, is a possible explanation for these findings. Another possibility is a malfunction in the signal transduction system of LH beyond the receptor level.
authors.affiliation: Timsit Institute of Reproductive Endocrinology, Tel Aviv Medical Center and the Sackler School of Medicine, Tel Aviv University, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Eckstein
authors.forename: I
authors.initials: I
authors.lastname: Huhtaniemi
authors.forename: I
authors.initials: I
authors.lastname: Vagman
authors.forename: P
authors.initials: P
authors.lastname: Pakarinen
authors.forename: R
authors.initials: R
authors.lastname: Limor
authors.forename: D
authors.initials: D
authors.lastname: Ayalon
mesh_terms: D000328:Adult; D001681:Biological Assay; D002996:Clomiphene; D003278:Contraceptives, Oral, Hormonal; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007247:Infertility, Female / Q000097:blood*; D007621:Karyotyping; D007986:Luteinizing Hormone / Q000097:blood* / Q000235:genetics; D008970:Molecular Weight; D009644:Norgestrel; D010062:Ovulation Induction; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D003278:Contraceptives, Oral, Hormonal; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D009644:Norgestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D019304:Ethinyl Estradiol-Norgestrel Combination; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone