title: [Cardiogenic shock and ventricular fibrillation induced by prajmalium and metoprolol poisoning].
abstract: Prajmaline is not a relatively well known and frequently used antiarrhythmic belonging to Class IA group of antiarrhythmics, which was administered to a young male with metoprolol for the treatment of parasystole. The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation. The patient's parameters were normalized after successful resuscitation, temporary pacemaker and two days long Dopamin therapy. Therapy was not regarded to be necessary for a few ventricular premature beats detected during a week observation period. The patient is without complaints now, and significant ventricular arrhythmias, or malignant ventricular ectopy hasn't been proved with ECG tests and Holter monitoring for more than three months. Due to adverse effect profile of prajmaline, even at commonly used doses it should be administered carefully and other agents should probably be considered first before beginning long term treatment with prajmaline.
authors.affiliation: Központi Aneszteziológia és Intenzív Betegellátó Osztály, Kaposi Mór Megyei Kórház, Kaposvár.
authors.forename: R
authors.initials: R
authors.lastname: Almási
authors.forename: F
authors.initials: F
authors.lastname: Mágel
authors.forename: G
authors.initials: G
authors.lastname: Kósik
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D004357:Drug Synergism; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D011219:Prajmaline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D012770:Shock, Cardiogenic / Q000139:chemically induced*; D014693:Ventricular Fibrillation / Q000139:chemically induced
chemical_list: D000889:Anti-Arrhythmia Agents; D011219:Prajmaline; D008790:Metoprolol
vernacular_title: Kardiogén shock és kamrafibrilláció kialakulása prajmalin és metoprolol mérgezés következtében.