title: Calcium transport pathways in the nucleus.
abstract: Due to the availability of new biophysical and biochemical techniques, there has recently been considerable progress in our understanding of Ca2+ transport inside, as well as into and out of, the nucleus. A number of Ca2+ transport pathways have been localized specifically in the outer or inner nuclear membrane and the Ca2+ permeability through the nuclear pore complex has been assessed. The nuclear envelope has characteristics similar to those of a leaky epithelium. The leak is through the nuclear pore complex. The outer nuclear membrane contains the Ca2+ ATPase whereas the functionally important inositol trisphosphate (IP3)-activated Ca2+ release channels are specifically localized in the inner nuclear membrane.
authors.affiliation: MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, P.O. Box 147, Liverpool, L69 3BX, UK.
authors.forename: O V
authors.initials: OV
authors.lastname: Gerasimenko
authors.forename: J V
authors.initials: JV
authors.lastname: Gerasimenko
authors.forename: A V
authors.initials: AV
authors.lastname: Tepikin
authors.forename: O H
authors.initials: OH
authors.lastname: Petersen
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium