YM-47522, a novel antifungal antibiotic produced by Bacillus sp. I. Taxonomy, fermentation, isolation and biological properties.
YM-47522, a novel antibiotic, was isolated from the culture broth of Bacillus sp. YL-03709B. The antibiotic was purified by centrifugal partition chromatography and ODS column chromatography. It exhibited potent in vitro antifungal activity especially against Rhodotorula acuta and Pichia angusta (MIC: 0.05 and 0.75 microgram/ml, respectively). It also showed moderate or weak antifungal activity against Candida albicans and Cryptococcus neoformans (MIC: 25 and 6.25 micrograms/ml, respectively), whereas it was inactive against filamentous fungi and bacteria.
Shibazaki
M
M
Microbiology Research Department, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Sugawara
T
T
Nagai
K
K
Shimizu
Y
Y
Yamaguchi
H
H
Suzuki
K
K
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000145:classification* / Q000378:metabolism* / Q000502:physiology; D002934:Cinnamates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation / Q000502:physiology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000473:pathology; D008826:Microbial Sensitivity Tests; D012248:Rhodotorula / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000935:Antifungal Agents; D002934:Cinnamates; D005231:Fatty Acids, Unsaturated; C099663:YM 47522