title: YM-47522, a novel antifungal antibiotic produced by Bacillus sp. II. Structure and relative stereochemistry.
abstract: YM-47522 (1) was isolated from the fermentation broth of Bacillus sp. YL-03709B as an antifungal antibiotic. The structure of 1 was elucidated by spectroscopic analyses. YM-47522 (1) consisted of C13 carboxylic acid amide and cinnamate moieties. The relative stereochemistry was also proposed on the basis of chemical transformation into a 1,3-diol acetonide and its NMR data.
authors.affiliation: Drug Serendipity Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugawara
authors.forename: M
authors.initials: M
authors.lastname: Shibazaki
authors.forename: H
authors.initials: H
authors.lastname: Nakahara
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D001407:Bacillus / Q000378:metabolism*; D002934:Cinnamates / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000935:Antifungal Agents; D002934:Cinnamates; D005231:Fatty Acids, Unsaturated; C099663:YM 47522