title: A mechanism for action of extremely low frequency electromagnetic fields on biological systems.
abstract: This report outlines a simple mechanism, based on the Hall Effect, by which static and low frequency (50-60 Hz) pulsed electromagnetic fields (PEMFs) can modify cation flow across biological membranes and alter cell metabolism. We show that magnetic fields commonly found in the environment can be expected to cause biologically significant interactions between transported cations and basic domains of cation channel proteins. We calculate that these interactions generate forces of a magnitude similar to those created by normal transmembrane voltage changes known to gate cation channels. Thus PEMFs are shown to have the potential of regulating flow through cation channels, changing the steady state concentrations of cellular cations and thus the metabolic processes dependent on cation concentrations.
authors.affiliation: Indiana University School of Medicine, Indiana State University, Terre Haute 47809, USA.
authors.forename: W X
authors.initials: WX
authors.lastname: Balcavage
authors.forename: T
authors.initials: T
authors.lastname: Alvager
authors.forename: J
authors.initials: J
authors.lastname: Swez
authors.forename: C W
authors.initials: CW
authors.lastname: Goff
authors.forename: M T
authors.initials: MT
authors.lastname: Fox
authors.forename: S
authors.initials: S
authors.lastname: Abdullyava
authors.forename: M W
authors.initials: MW
authors.lastname: King
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D015640:Ion Channel Gating / Q000528:radiation effects; D007473:Ion Channels / Q000502:physiology / Q000528:radiation effects*; D008433:Mathematics; D008954:Models, Biological
chemical_list: D007473:Ion Channels