title: Significance of urinary tissue polypeptide specific antigen (TPS) determination in patients with urothelial carcinoma.
abstract: Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (UTPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.
authors.affiliation: Department of Nuclear Medicine, National Cheng Kung University Hospital Tainan, Taiwan, Republic of China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Yao
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
authors.forename: S H
authors.initials: SH
authors.lastname: Chan
authors.forename: N H
authors.initials: NH
authors.lastname: Chow
authors.forename: H L
authors.initials: HL
authors.lastname: Cheng
authors.forename: T S
authors.initials: TS
authors.lastname: Tzai
authors.forename: S N
authors.initials: SN
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000652:urine*; D014408:Biomarkers, Tumor / Q000652:urine*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000401:mortality / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000652:urine; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000652:urine; D010455:Peptides / Q000652:urine*; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D014570:Urologic Diseases / Q000652:urine; D014571:Urologic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000652:urine*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D010455:Peptides; C089984:tissue polypeptide specific antigen