On interspecies correlations of carcinogenic potencies.
It has been established in the literature that constraints on the designs of experiments used to estimate carcinogenic potencies cause overestimation of true biological interspecies correlations of such potencies. This article explores the potential for appreciable underestimation of interspecies correlations, due to the experimental error that occurs in the estimation of carcinogenic potencies.
Kodell
R L
RL
Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. rkodell@fdant.nctr.fda.gov
Basu
A P
AP
Gaylor
D W
DW
D000818:Animals; D001681:Biological Assay; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D004195:Disease Models, Animal; D051379:Mice; D008954:Models, Biological; D009010:Monte Carlo Method; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D015203:Reproducibility of Results; D013045:Species Specificity
D002273:Carcinogens