[Microsensory systems in cell biology basic research and medical diagnostics].
The development of an integrated sensor system, called the physiocontrol microsystem, is presented. It is suited for microscopy, and works with both adherent cell types and cultures growing in suspension, as well as with tissue biopsies. The central part, a miniaturized culture chamber equipped with differently constructed microsensors, allows continuous observation of important physiological parameters even in the course of long-lasting experiments. Besides a description of the physical components, the study provides a summary of selected applications of the physiocontrol microsystem in basic cellular research and biomedical diagnostics.
Brischwein
M
M
AG Medizinische Physik und Elektronenmikroskopie, Institut für Immunbiologie der Universität, Freiburg, Germany.
Baumann
W
W
Ehret
R
R
Schwinde
A
A
Kraus
M
M
Wolf
B
B
D000818:Animals; D001695:Biology / Q000295:instrumentation / Q000379:methods*; D001706:Biopsy; D002477:Cells / Q000166:cytology / Q000648:ultrastructure; D006801:Humans; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D008904:Miniaturization; D010336:Pathology / Q000295:instrumentation / Q000379:methods*; D014407:Tumor Cells, Cultured
Mikrosensorische Systeme in der zellbiologischen Grundlagenforschung und der medizinischen Diagnostik.