Cytotoxicity and NMR spectral assignments of ergolide and bigelovin.
Two potent cytotoxic sesquiterpene lactones, ergolide (1) and bigelovin (2) were isolated from Inula hupehensis I. helianthus-aquatica and their structures and NMR data were assignment unambiguously by using a combination of one-and two-dimensional NMR techniques and computer modeling calculations.
Wang
Q
Q
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Academia Sinica, People's Republic of China.
Zhou
B N
BN
Zhang
R W
RW
Lin
Y Y
YY
Lin
L Z
LZ
Gil
R R
RR
Cordell
G A
GA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry* / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; C099797:ergolide; C099796:bigelovin