title: [Correlation between symptoms and diagnosis in pharmacotherapeutic decision process].
abstract: Evaluation of influence of psychopathological symptoms (AMDP System) and diagnosis (ICD-9) on the choice of drug therapy (neuroleptics or antidepressants) for psychiatric in-patients was the aim of this work. Statistical analysis of 3745 patients led to three different decision-making procedures. These procedures are based on symptoms or diagnoses alone or on both symptoms and diagnosis. CART-Analysis was used for statistical analysis. Reclassification errors for neuroleptics were always larger than reclassification errors for antidepressants. The results show that both symptoms (error neuroleptics 20.2%, respectively antidepressants 15.0%) and diagnosis (20.8%, resp. 11.9%) alone are not sufficient to explain the choice of drug therapy. Lowest error rates were gained in a hierarchical model for the choice of drug treatment where both diagnosis and symptoms were used (17.1%, resp. 10.1%).
authors.affiliation: Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München.
authors.forename: K
authors.initials: K
authors.lastname: Adelhard
authors.forename: A
authors.initials: A
authors.lastname: Strauss
authors.forename: H J
authors.initials: HJ
authors.lastname: Möller
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003663:Decision Trees; D004359:Drug Therapy, Combination; D006801:Humans; D001523:Mental Disorders / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D010343:Patient Admission; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents
vernacular_title: Der Zusammenhang zwischen Symptomatik und Diagnose im pharmakotherapeutischen Entscheidungsprozess.