title: t(1;19)(q23;p13) in a case of acute monocytic leukemia.
abstract: Translocation (1;19)(q23;p13) is considered a specific chromosome aberration in acute lymphoblastic leukemia (ALL). We report a case of M5 acute nonlymphocytic leukemia (ANLL) with t(1;19). In all mitoses studied from peripheral blood (PB) cells, the pathological karyotype 51,XX,t(1;19)(q23;p13),+8, +der(19)t(1;19)(q23;p13), +3mar was detected. No rearrangement of the E2A gene was detected. We believe this case shows that cytogenetically indistinguishable aberrations may be accompanied by quite different molecular events.
authors.affiliation: Department of Oncology and Hematology, Medical University Clinic, Hamburg, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Weh
authors.forename: P
authors.initials: P
authors.lastname: Jonveaux
authors.forename: D
authors.initials: D
authors.lastname: Seeger
authors.forename: J
authors.initials: J
authors.lastname: Felgner
authors.forename: D K
authors.initials: DK
authors.lastname: Hossfeld
mesh_terms: D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic