title: Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain.
abstract: An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.
authors.affiliation: Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H R
authors.initials: HR
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: H D
authors.initials: HD
authors.lastname: Uhm
authors.forename: J B
authors.initials: JB
authors.lastname: Ahn
authors.forename: S Y
authors.initials: SY
authors.lastname: Rha
authors.forename: J Y
authors.initials: JY
authors.lastname: Cho
authors.forename: J I
authors.initials: JI
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Chung
authors.forename: J K
authors.initials: JK
authors.lastname: Roh
authors.forename: J S
authors.initials: JS
authors.lastname: Min
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: D H
authors.initials: DH
authors.lastname: Shin
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Hong
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases