Occlusion of the neonatal patent ductus arteriosus with a simple retrievable device: a feasibility study.
OBJECTIVE
To examine the feasibility of transvenous placement of a new memory-shaped, small, retrievable coil that has a smaller-caliber delivery system than currently available devices, for closure of the patent ductus arteriosus (PDA).


METHODS
Through 4 or 5 Fr vascular sheaths and 4 or 5 Fr end-hold catheters, the coils were delivered and placed in piglets (n = 10) with PDA. The coils were made from 0.018" (0.46 mm) or 0.028" (0.71 mm) stainless steel guidewire. Mounted for delivery, the new device has the appearance of a conventional guidewire. This neonatal PDA model was created without major surgery or drugs by stenting the ductus arteriosus.


RESULTS
The memory-shaped coils were easily delivered. Coils not optimally placed were retrieved and repositioned. Occlusion of the ductus arteriosus as early as a half-hour after delivery was shown angiographically and confirmed by histopathology.


CONCLUSIONS
This new, small-caliber, simple device was found to be effective for closure of the PDA in this animal model. Longer-term observations are needed.
Neuss
M B
MB
Department of Cardiology, Children's Hospital, University of Bonn, Adenauerallee 119, D-5300, Bonn 1, Germany.
Coe
J Y
JY
Tio
F
F
Le
T P
TP
Grabitz
R
R
Redel
D A
DA
D000818:Animals; D000831:Animals, Newborn; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D005240:Feasibility Studies; D011859:Radiography; D013193:Stainless Steel; D013552:Swine
D013193:Stainless Steel