Alpha-fetoprotein production by a malignant mixed müllerian tumour of the uterus.
A case of alpha-fetoprotein production by a uterine malignant mixed müllerian tumour is described. The patient was a 68 year old woman who developed intraabdominal recurrence of a stage 1 uterine tumour which had been treated surgically seven years previously. Her serum alpha-fetoprotein was raised at 21,000 micrograms/l (normal < 10 micrograms/l) and staining with immunoperoxidase confirmed that the tumour was the site of alpha-fetoprotein production. The patient was treated with combination chemotherapy but died two weeks after the first course. This is believed to be only the second such case reported.
Phillips
K A
KA
Department of Haematology and Oncology, Peter MacCallum Hospital, Melbourne.
Scurry
J P
JP
Toner
G
G
D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D018200:Mixed Tumor, Mullerian / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D014594:Uterine Neoplasms / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins