title: Lower urinary tract reconstruction following cystectomy: experience and results in 96 patients using the orthotopic ileal bladder substitution of Studer et al.
abstract: Between 1989 and 1993 96 patients (89 males and 7 females) affected with invasive neoplasms of the bladder underwent surgery consisting of the creation of an orthotopic ileal neobladder according to Studer et al., after radical cystectomy. Patient selection and details of the surgical procedure are described. An accurate follow-up of 3-60 months (mean: 28 months) is presented. There have been 6 perioperative deaths (6.2%) and 11 early complications, all directly related to the neobladder and requiring reoperation in 6 cases (6.2%). Late complications required rehospitalization in 23 cases (23.9%) and a second reoperation was necessary in 10 (10.4%). The urodynamic tests show that the neobladder assumes an average capacity at about 330 cm3 after 1 year. Pressure at maximum capacity decreases in time and ranges from 10 to 20 cm H2O at 2 years. After 1 year, the complete urinary continence rate by day is 97% and the stress incontinence rate is 22%. Night-time continence, instead, increases to 74% after 1 year and to 83% after 2 years. In female patients, the functional results were satisfactory thanks to careful patient selection and to the surgical procedure adopted. Twenty-four patients had disease progression; 17 of these patients with locally advanced neoplasms died. The authors believe that the orthotopic ileal continent reservoir can be a satisfactory solution after cystectomy for bladder cancer, offering the patients a better quality of life compared to other urinary diversions both in male and female patients.
authors.affiliation: Department of Urologic Oncology, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cancrini
authors.forename: P
authors.initials: P
authors.lastname: De Carli
authors.forename: V
authors.initials: V
authors.lastname: Pompeo
authors.forename: H
authors.initials: H
authors.lastname: Fattahi
authors.forename: L
authors.initials: L
authors.lastname: Lamanna
authors.forename: C
authors.initials: C
authors.lastname: Giuseppe
authors.forename: R
authors.initials: R
authors.lastname: Cantiani
authors.forename: G
authors.initials: G
authors.lastname: Mainiero
authors.forename: M
authors.initials: M
authors.lastname: von Heland
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000601:surgery*; D015331:Cohort Studies; D015653:Cystectomy / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000502:physiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012086:Reoperation; D012737:Sex Factors; D001743:Urinary Bladder / Q000502:physiology / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000601:surgery*; D014547:Urinary Diversion / Q000379:methods*