title: Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
abstract: The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma.
authors.affiliation: Institute of Pathology, University of Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Lösch
authors.forename: P
authors.initials: P
authors.lastname: Kohlberger
authors.forename: G
authors.initials: G
authors.lastname: Gitsch
authors.forename: A
authors.initials: A
authors.lastname: Kaider
authors.forename: G
authors.initials: G
authors.lastname: Breitenecker
authors.forename: C
authors.initials: C
authors.lastname: Kainz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis*; D002402:Cathepsin D / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008247:Lysosomes / Q000201:enzymology*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D002402:Cathepsin D