[Pulsed Doppler ultrasonography to measure the vasoactive effects of hemoglobin-dextran 10-benzene-tetracarboxylate, a potential erythrocyte substitute].
The effects of Dextran-Benzene-Tetracarboxylate-Hemoglobin (Dex-BTC-Hb), a chemically-modified hemoglobin-based oxygen carrier, on the vascular tone were compared to those of standard solutions, i.e. the animal's own blood and a 50 milligrams albumin solution, by measuring the carotid blood flow velocity, the mean arterial pressure, the heart rate and respiratory frequency, in anesthetized Hartley guinea pigs after a hemorragic shock. Stroma-free hemoglobin induced 40% hypertension and a 110% rise in blood flow velocity immediately after injection. The velocity was still increased 38%, 3 hours after injection. The calculations of the vascular resistances showed an increase in carotid vascular tone. Dex-BTC-Hb brought about 35% hypertension for two hours with no significant modifications of the vascular tone. These effects are similar to those of the albumin solution. These results indicate that, unlike stroma-free hemoglobin, Dex-BTC-Hb does not significantly affect the vascular tone, probably because of its slight interaction with the factors that regulate vascular tone.
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Laboratoire d'Hématologie et de Physiologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université Henri-Poincaré-Nancy 1, France.
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Labrude
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Vigneron
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D000818:Animals; D001692:Biological Transport; D001802:Blood Substitutes / Q000494:pharmacology*; D001804:Blood Transfusion, Autologous; D003911:Dextrans / Q000494:pharmacology*; D006168:Guinea Pigs; D006454:Hemoglobins / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects*; D010100:Oxygen / Q000097:blood / Q000493:pharmacokinetics; D018617:Ultrasonography, Doppler, Pulsed; D014666:Vasomotor System / Q000000981:diagnostic imaging / Q000187:drug effects*
D001802:Blood Substitutes; D003911:Dextrans; D006454:Hemoglobins; C095659:hemoglobin-dextran 10-benzene-tetracarboxylate; D010100:Oxygen
Mesure par ultrasonographie Doppler pulsé, des effets vasoactifs de l'hémoglobine-dextrane 10-benzène-tétracarboxylate, substitut èrythrocytaire potentiel.