title: Temporal variation in hepatic superoxide dismutase activity in mice.
abstract: Circadian variations in superoxide dismutase (SOD) activity were determined in liver homogenates of Balb-C mice that were synchronized under controlled environmental conditions with 12 h light:12 h dark. The activity of hepatic SOD exhibited a significant circadian rhythm, with a minimum at 01:00 h and a maximum at 10:00-13:00 h. It is concluded that fluctuations in hepatic SOD activity render mice more susceptible to the toxic effects of reactive oxygen radicals at particular times of the day.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Hodoğlugil
authors.forename: O
authors.initials: O
authors.lastname: Ongun
authors.forename: Z
authors.initials: Z
authors.lastname: Güney
authors.forename: N
authors.initials: N
authors.lastname: Altan
authors.forename: H
authors.initials: H
authors.lastname: Zengil
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002940:Circadian Rhythm; D003624:Darkness; D008027:Light; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017382:Reactive Oxygen Species / Q000633:toxicity; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase