Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure.
The induction of sister chromatid exchanges (SCE), structural chromosome aberrations (CA) or micronuclei (MN) was investigated in peripheral lymphocytes of a group of Italian floriculturists exposed to a mixture of pesticides. No statistically significant difference in the frequencies of cytogenetic damage was detected between exposed and control subjects. Assessment of the effect of confounding factors indicated that smoking affected both SCE and CA frequencies. Multiple regression analysis showed that in heavy smokers (> or = 20 cigarettes/day), SCE and CA levels increased significantly by 17% and 54%, respectively, as compared to non-smokers.
Scarpato
R
R
Dipartimento di Scienze dell'Ambiente e del Territorio, Università di Pisa, Italy.
Migliore
L
L
Angotzi
G
G
Fedi
A
A
Miligi
L
L
Loprieno
N
N
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004249:DNA Damage; D005260:Female; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000009:adverse effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking / Q000009:adverse effects
D010575:Pesticides