Dietary fatty acids, low density lipoprotein composition and oxidation and primate atherosclerosis.
Low density lipoproteins (LDL) were isolated from nonhuman primates fed isocaloric diets rich in different types of fatty acids. These diets contained 35% of calories as fat enriched in fatty acids from the following sources: lard that is rich in saturated fatty acids, safflower oil rich in oleic acid, safflower oil rich in linoleic acid and menhaden oil that is rich in n-3 fatty acids. LDL composition reflected the dietary fats. LDL were subjected to oxidation using copper ions and azobis(2-amidinopropane) x 2HCl. In general, the sensitivity of LDL to oxidation depended on both the poly-unsaturated fatty acid and vitamin E content. However, the lag times calculated for the copper ion catalyzed oxidations did not show the linear dependence on vitamin E content that was found for azobis(2-amidinopropane) catalyzed oxidation.
Thomas
M J
MJ
Department of Biochemistry, Wake Forest University Medical Center, The Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA.
Rudel
L L
LL
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D004041:Dietary Fats / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis*; D008077:Lipoproteins, LDL / Q000032:analysis* / Q000378:metabolism; D008252:Macaca fascicularis; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000032:analysis
D004041:Dietary Fats; D005227:Fatty Acids; D008077:Lipoproteins, LDL; D014810:Vitamin E