A pilot study on risk factors and p53 gene expression in colorectal cancer.
Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining. The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors.
Fredrikson
M
M
Department of Occupational and Environmental Medicine, University Hospital, Linköping, Sweden.
Axelson
O
O
Sun
X F
XF
Arbman
G
G
Nilsson
E
E
Nordenskjöld
B
B
Sjödahl
R
R
Söderkvist
P
P
D000428:Alcohol Drinking; D000959:Antihypertensive Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D016158:Genes, p53; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D007150:Immunohistochemistry; D007501:Iron; D009679:Nuclear Family; D009790:Occupations; D010865:Pilot Projects; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis
D000959:Antihypertensive Agents; D016159:Tumor Suppressor Protein p53; D006830:Hydralazine; D007501:Iron