[Immunotropic activity of antimicrobial agents used in tuberculosis].
Mice with experimental tuberculosis were given isoniazid, rifampicin, erythromycin, cefotaxime, ofloxacin. Erythromycin, cefotaxime and ofloxacin enhanced macrophage activity if their course did not exceed 2-4 weeks. Isoniazid and rifampicin for a short time inhibited macrophage activity then stimulated it. These findings led the authors to the conclusion that erythromycin, cefotaxime and ofloxacin must be used only in short courses.
Aleksandrova
A E
AE
Vinogradova
T I
TI
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D002439:Cefotaxime / Q000494:pharmacology / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use; D004917:Erythromycin / Q000494:pharmacology / Q000627:therapeutic use; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy* / Q000276:immunology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D002511:Cephalosporins; D004917:Erythromycin; D015242:Ofloxacin; D002439:Cefotaxime; D007538:Isoniazid
Immunotropnaia aktivnost' protivomikrobnykh sredstv, ispol'zuemykh vo ftiziatrii.