Lack of effect of 6 g inositol treatment of post-ECT cognitive function in humans.
Cholinergic agonists have been reported to ameliorate ECT-induced memory impairment. Inositol metabolism is involved in the second messenger system for several muscarinic cholinergic receptors. Inositol 6 g daily was given in a cross-over double-blind manner for 5 days before the 5th or 6th ECT in a series of patients. No effect was found on post-ECT cognitive impairment.
Levine
J
J
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev Beersheva Israel.
Pomerantz
T
T
Stier
S
S
Belmaker
R H
RH
D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy; D004311:Double-Blind Method; D004565:Electroconvulsive Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D007294:Inositol / Q000008:administration & dosage*; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D011292:Premedication; D011618:Psychotic Disorders / Q000523:psychology / Q000628:therapy; D012559:Schizophrenia / Q000628:therapy; D012565:Schizophrenic Psychology; D017211:Treatment Failure
D007294:Inositol