A double-blind, randomized, placebo-controlled, multi-center study of brofaromine in the treatment of post-traumatic stress disorder.
A large multi-center, double-blind, parallel trial to assess the efficacy of brofaromine in the treatment of post traumatic stress disorder (PTSD) failed to show a significant difference between the brofaromine and placebo treatment groups. The placebo response rate in this study was higher than that in previously published double-blind, placebo-controlled studies of PTSD.
Baker
D G
DG
VA Medical Center, Cincinnati, Ohio, USA.
Diamond
B I
BI
Gillette
G
G
Hamner
M
M
Katzelnick
D
D
Keller
T
T
Mellman
T A
TA
Pontius
E
E
Rosenthal
M
M
Tucker
P
P
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy*
D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; C038213:brofaromine