Inhibitory effect of oral administration of Monascus pigment on tumor promotion in two-stage carcinogenesis in mouse skin.
Monascus pigment was extracted from red malted rice, Monascus anka. It has been used as coloring matter for foodstuffs in Japan and certain Asian countries. Oral administration of Monascus pigment suppressed the tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in mice following initiation by 7,12-dimethylbenz[a]anthracene.
Yasukawa
K
K
College of Pharmacy, Nihon University, Chiba, Japan.
Takahashi
M
M
Yamanouchi
S
S
Takido
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D003043:Cocarcinogenesis; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010860:Pigments, Biological / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors*
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010860:Pigments, Biological; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate