Serum nifedipine concentrations and response of patients with pulmonary hypertension.
In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.
Phillips
B G
BG
Department of Pharmacy Practice, University of Illinois, Chicago 60612 USA.
Bauman
J L
JL
Schoen
M D
MD
Hoon
T J
TJ
Schrader
B J
BJ
Rich
S
S
D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage* / Q000097:blood*; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000097:blood*
D014665:Vasodilator Agents; D009543:Nifedipine