Circadian rhythms and the onset of myocardial infarction: clinical implications.
There is much current interest in the development of therapeutic strategies which may alter the circadian pattern of cardiovascular events such as myocardial infarction and sudden cardiac death. It is not known whether manipulating rhythmic processes and providing active medication at the most vulnerable periods during the day or night will protect patients and reduce the risk of death. This review examines the evidence from the limited available data and assess the feasibility of implementing such strategies.
Purcell
H
H
Royal Brompton Hospital, London, UK.
Mulcahy
D
D
D001794:Blood Pressure / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology*; D009543:Nifedipine / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013564:Sympathetic Nervous System / Q000503:physiopathology; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents; D009543:Nifedipine