-Effect of endogenous opioids on adrenal cortex activity in women with hypothalamic amenorrhea-.
OBJECTIVE
Within an ovulation induction study, we investigated the activity and reactivity of the hypothalamic-pituitary-adrenal axis in women suffering from hypothalamic amenorrhea by using naloxone.


METHODS
The central opioid receptors were blocked by means of a naloxone bolus injection of 4 mg i.v. daily.


RESULTS
Before and after receptor blockade, the cortisol secretion showed diverse results independently from the hypothalamic opioid tone. The cortisol levels were not elevated. Also, the basal secretion of cortisol and DHEAS was nonspecific among the various responder groups.


CONCLUSIONS
It seems that there is no close relationship between central opioid tone and adrenal function in hypothalamic amenorrhea.
Krause
B T
BT
Klinik für Frauenheilkunde und Geburstshilfe, Medizinischen Fakultät, Ernst-Moritz-Arndt-Universität, Greifswald, Deutschland.
Möller
S
S
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy / Q000503:physiopathology*; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000097:blood; D009270:Naloxone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D010062:Ovulation Induction; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D016896:Treatment Outcome
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D009270:Naloxone; D003687:Dehydroepiandrosterone; D007986:Luteinizing Hormone; D006854:Hydrocortisone
Der Einfluss endogener Opioide auf die Nebennierenrindenaktivität bei Frauen mit hypothalamischer Amenorrhö.