[An analysis of DNA reparative synthesis in the lymphocytes of bronchial asthma patients].
Spontaneous and UV-stimulated unschedule syntheses (US) of DNA in the peripheral blood lymphocytes and HLA antigens were investigated for asthmatic patients. The index of stimulation (IS) of DNA repair was determined as the ratio of the values of UV-stimulated US to spontaneous US. In the patients, a significant elevation of the intensity of spontaneous DNA US and the decrease in IS values were revealed as compared with the healthy controls. At the same time the intensity of UV-stimulated IS did not differ in patients and the control subjects. The values of IS appeared to be significantly higher in those patients who had the HLA-Al antigen in their phenotype compared to those who had not. Possible mechanisms for the alteration of the DNA repair capacity of lymphocytes and for the relationship between cytogenetic damages and immunogenetic features in asthmatic patients are discussed.
Soliev
A K
AK
Barabanova
E N
EN
Lintsov
A E
AE
Uslontsev
B M
BM
Bubnova
L N
LN
Genter
E I
EI
Mikhel'son
V M
VM
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood* / Q000276:immunology; D004247:DNA / Q000096:biosynthesis* / Q000097:blood / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014466:Ultraviolet Rays
D006680:HLA Antigens; D004247:DNA
Analiz reparativnogo sinteza DNK v limfotsitakh bol'nykh bronkhial'noĭ astmoĭ.