Lack of expression of c-erbB-2 oncoprotein in human esophageal squamous cell carcinomas.
Fifty-one cases of esophageal squamous cell carcinoma were immunohistochemically investigated with monoclonal c-erbB 2 oncoprotein antibody. No tumor showed plasma membrane immunostaining for c-erbB-2 protein. Occasionally, unspecific cytoplasmic staining was found in minor tumor cell populations. The present results show that c-erbB-2 oncoprotein is not overexpressed in esophageal squamous cell carcinomas and does not play a central role in the tumorigenesis.
Suo
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Department of Pathology, Norwegian Radium Hospital, Oslo, Norway. zhenhes@radium.uio.no
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Holm
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Nesland
J M
JM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001943:Breast Neoplasms / Q000737:chemistry; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D003593:Cytoplasm / Q000737:chemistry; D004848:Epithelium / Q000737:chemistry; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D051379:Mice; D009194:Myeloma Proteins / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology / Q000502:physiology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000276:immunology / Q000502:physiology; D012189:Retrospective Studies
D000911:Antibodies, Monoclonal; D009194:Myeloma Proteins; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases