title: A comparison between ketorolac and diclofenac in laparoscopic sterilization.
abstract: We compared ketorolac and diclofenac for the prevention and treatment of post-operative pain in patients undergoing laparoscopic sterilization. Fifty ASA I or II women were allocated randomly to receive either diclofenac 75 mg or ketorolac 30 mg intramuscularly 30-90 min before general anaesthesia. Pain scores were assessed half-hourly in the recovery room and then at 2 h and 4 h in the ward. In the recovery room, pain was treated with a second dose of the study drug, followed by parenteral pethidine if necessary. Four patients in the diclofenac group and five patients in the ketorolac group requested no analgesics after surgery. Fifteen patients from each group had satisfactory analgesia after the second dose of study drug. Pain scores were similar between groups at all times. The median (range) initial pain score in the recovery room was 5 (0-9.5) in the diclofenac group and 5 (1-9) in the ketorolac group. Pain at the injection site was more common after diclofenac than ketorolac (12 vs. 3, P < 0.05). In conclusion, both intramuscular diclofenac and ketorolac were relatively ineffective in controlling the pain after laparoscopic sterilization. The drugs were equally well tolerated, but more patients complained of pain at the injection site after diclofenac.
authors.affiliation: Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong.
authors.forename: P T
authors.initials: PT
authors.lastname: Chui
authors.forename: T
authors.initials: T
authors.lastname: Gin
mesh_terms: D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006757:Hospital Units; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects; D020910:Ketorolac; D010535:Laparoscopy; D008614:Meperidine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011292:Premedication; D011997:Recovery Room; D013246:Sterilization, Tubal; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D008614:Meperidine; D014046:Tolmetin; D020910:Ketorolac