Identification of dioxin-responsive elements (DREs) in the 5' regions of putative dioxin-inducible genes.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an exogenous ligand for the cytosolic aryl hydrocarbon receptor (AhR), a ligand-inducible transcription factor whose exact physiological role remains elusive. TCDD has been shown to modulate the expression of a large array of genes, albeit often indirectly, by demonstration of protein or mRNA upregulation. Here, by computer analysis of available promoter sequences, we identify dioxin-responsive elements in the promoter regions of many putative AhR regulated and therefore dioxin-inducible genes.
Lai
Z W
ZW
Institue of Environmental Hygiene, University of Düsseldorf, Germany.
Pineau
T
T
Esser
C
C
D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D016208:Databases, Factual; D015536:Down-Regulation; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D016239:MEDLINE; D051379:Mice; D008969:Molecular Sequence Data; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism* / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism; D015854:Up-Regulation
D016207:Cytokines; D000072317:Polychlorinated Dibenzodioxins; D012333:RNA, Messenger; D018336:Receptors, Aryl Hydrocarbon