[Effect of the antioxidant dibunol on hemostatic parameters in patients with non-healing ulcers].
Dibunol, antioxidant drug, made in Russia was given to 42 patients aged 18-59 with unhealing ulcer 0.64 c 0.06 cm in diameter treated previously without effect for 99.74 +/- 30.6 days. Scarring came in 99.6% of cases on treatment day 15.9 +/- 1.23 without appearance of a rough scar. Recurrences occurred 6 months later in 7.1% of patients. Dibunol did not suppress antioxidant system of the serum, lowered serum level of lipid hydroperoxides, stimulated activity of natural antioxidants in the mucous gastroduodenal zone, had no effect on hormonal homeostasis and blood coagulation.
Podoprigorova
V G
VG
Khibin
L S
LS
Barcel'
V A
VA
Kogan
I G
IG
Anokhina
E I
EI
Sidorenkova
E N
EN
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
D000975:Antioxidants; D006728:Hormones; D002084:Butylated Hydroxytoluene
Vliianie antioksidanta dibunola na otdel'nye pokazateli gemostaza y bol'nykh iazvennoĭ bolezn'iu s dlitel'no nerubtsuiushchimisia iazvami.