title: Assays of the biological activities of two fatty acid derivatives formed in the edible mushrooms cantharellus cibarius and C. tubaeformis as a response to injury.
abstract: Cibaric acid (1) and 10-hydroxy-8-decenoic acid (2) are two fatty acid derivatives that are formed in the fruit bodies of Cantharellus cibarius (chanterelle) and C. tubaeformis as a response to injury. Unlike the potent defensive sesquiterpenes formed in injured fruit bodies of the pungent Lactarius species, compounds 1 and 2 only possess very weak antimicrobial and cytotoxic activity. Compound 2 was found to be a very weak direct-acting mutagen in the Ames test (<1 revertant/microgram and plate), while cibaric acid (1) was inactive in this assay. As 1 is destroyed during cooking, there are currently no reasons for suspecting that the consumption of C. cibarius poses a risk to consumers.
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: P
authors.initials: P
authors.lastname: Morales
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000633:toxicity*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D007668:Kidney; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D009153:Mutagens; C099800:cibaric acid; C099802:10-hydroxy-8-decenoic acid