[The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor].
Concentration of markers for platelet and leukocyte local activation including platelets factor four, beta-thromboglobulin, granulyte elastate and beta-glucunidase was measured in gingival fluid from patients with gingivitis and periodontitis. It has been shown that there is a statistically significant increase in level of markers in these patients. The increase correlated with degree of periodontal injury. Radioimmune assay of concentrations of platelet-activating factor (PAF) in gingival fluid and gingival tissue was performed. Its concentration also increased in gingivitis and periodontitis depending on intensity of the tissue injury. A close correlation between the PAF concentration has been revealed. It is likely that hypergeneration of PAF in the endothelium is a mechanism for the blood cell activation and accumulation in gingival tissue resulting in its failure due to secretion of different deleterious agents from the activated cells.
Leont'ev
V K
VK
Kankanian
A P
AP
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D002908:Chronic Disease; D005881:Gingiva / Q000737:chemistry; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005891:Gingivitis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008875:Middle Aged; D010518:Periodontitis / Q000209:etiology / Q000276:immunology*; D010972:Platelet Activating Factor / Q000032:analysis / Q000502:physiology*
D015415:Biomarkers; D010972:Platelet Activating Factor
Lokal'naia aktivatsiia leĭkotsitov i trombotsitov pri zabolevaniiakh parodonta: rol' trombotsitaktiviruiushchego faktora.