title: Multimodal management of diffuse neonatal hemangiomatosis.
abstract: Diffuse neonatal hemangiomatosis is a rare, frequently fatal disorder. We describe the case of a neonate with numerous cutaneous and ocular hemangiomas. Hepatic hemangiomas were noted at 4 weeks of age, associated with congestive heart failure resulting from hepatic arteriovenous shunting. This condition was controlled by treatment with prednisone, interferon alfa-2b and hepatic embolization. Treatment of cutaneous hemangiomas with the tunable dye laser prevented hemorrhage, facilitated routine skin care, and allowed uninhibited intravenous access during hospitalization.
authors.affiliation: Department of Dermatology, Oregon Health Sciences University, Portland, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: Stratte
authors.forename: W D
authors.initials: WD
authors.lastname: Tope
authors.forename: C L
authors.initials: CL
authors.lastname: Johnson
authors.forename: N A
authors.initials: NA
authors.lastname: Swanson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006333:Heart Failure / Q000209:etiology; D006391:Hemangioma / Q000150:complications / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D015811:Iris Neoplasms / Q000628:therapy*; D017075:Laser Coagulation; D008113:Liver Neoplasms / Q000150:complications / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use; D011994:Recombinant Proteins; D012164:Retinal Diseases / Q000628:therapy*; D012878:Skin Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D005938:Glucocorticoids; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011241:Prednisone