title: Massive vulvar edema complicating tocolysis in a patient with twins. A case report.
abstract: BACKGROUND
  Severe vulvar edema is an extremely rare complication of pregnancy. One other case of tocolysis-induced vulvar edema has been reported, as have five cases of postpartum vulvar edema, associated with an 80% maternal mortality rate.
  
  
  METHODS
  A multipara with a twin gestation presented with premature labor at 31 weeks. The patient had no history of trauma, lymphatic obstruction, venous obstruction or infection. On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia. The following day the vulvar edema had increased and spread to the sacrum. The patient was normotensive and afebrile. Resolution occurred in spite of continuous tocolytic therapy, which was stopped at 35 weeks. Two days later, on hospital day 27, the patient spontaneously delivered two healthy, male infants.
  
  
  CONCLUSIONS
  The two reported cases of tocolysis-induced vulvar edema were not fatal and resolved after repositioning the patient in one case and by cesarean section in the other. However, since maternal death has occurred with postpartum vulvar edema, the patient with vulvar edema merits special attention. The WBC count should be determined and the patient's circulatory status evaluated to rule out hypovolemia.
authors.affiliation: University of Vermont College of Medicine, Burlington, USA.
authors.forename: L
authors.initials: L
authors.lastname: Trice
authors.forename: H
authors.initials: H
authors.lastname: Bennert
authors.forename: P G
authors.initials: PG
authors.lastname: Stubblefield
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004487:Edema / Q000139:chemically induced*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D008278:Magnesium Sulfate / Q000009:adverse effects; D008297:Male; D009543:Nifedipine / Q000009:adverse effects; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011247:Pregnancy; D013726:Terbutaline / Q000009:adverse effects; D015149:Tocolytic Agents / Q000009:adverse effects*; D014427:Twins; D014845:Vulvar Diseases / Q000139:chemically induced*
chemical_list: D005938:Glucocorticoids; D015149:Tocolytic Agents; D008278:Magnesium Sulfate; D001623:Betamethasone; D009543:Nifedipine; D013726:Terbutaline