Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker.
Using a mouse protein tyrosine phosphatase cDNA fragment as a probe, cosmid clones containing segments of the human IA-2 PTPase gene (PTPRN) were isolated. The gene was assigned to chromosome region 2q35 --> q36.1 by fluorescence in situ hybridization. In an intronic region of the IA-2 gene a polymorphic microsatellite sequence was found, which will be useful as a genetic marker for the 2q35 --> q36 region.
van den Maagdenberg
A M
AM
Department of Cell Biology and Histology, University of Nijmegen, The Netherlands.
Olde Weghuis
D
D
Rijss
J
J
van de Wetering
R A
RA
Wieringa
B
B
Geurts van Kessel
A
A
Hendriks
W J
WJ
D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens; D001483:Base Sequence; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D003360:Cosmids / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004276:DNA, Satellite / Q000235:genetics; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007527:Isoenzymes / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8; D013045:Species Specificity
D001324:Autoantigens; D018076:DNA, Complementary; D004276:DNA, Satellite; D005819:Genetic Markers; D007527:Isoenzymes; D008565:Membrane Proteins; C516862:PTPRN protein, human; D017027:Protein Tyrosine Phosphatases; C516863:Ptprn protein, mouse; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8