[Morphological features of senile and secondary amyloidosis of the iris and sclera in patients with glaucoma].
Morphologic analysis of 173 biopsy specimens of the iris and sclera removed during antiglaucoma surgery in 115 patients with open-angle glaucoma revealed in 44.4% cases extracellular depositions of amyloid, which aggravated the course of glaucomatous process and were pathogenetically significant. Amyloidosis was revealed in the sclera in 82% cases and in the iris in 70%. Amyloid was detected by Congo red staining with control in polarized light and by toluidine blue staining for chondroitin and dermatan sulfates. Vascular and muscular (involving the pupil muscles) forms of amyloidosis were detected in the iris, pericollagen and focal forms in the draining system and sclera. The authors discuss the contribution of amyloidosis to the pathogenesis of glaucoma. These findings confirm M.M. Krasnov's concept about glaucoma polymorphism.
Krasnov
M M
MM
Ziangirova
G G
GG
Antonova
O V
OV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D004396:Coloring Agents; D003224:Congo Red; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000473:pathology; D006801:Humans; D007498:Iris / Q000473:pathology; D008875:Middle Aged; D012590:Sclera / Q000473:pathology; D015422:Scleral Diseases / Q000150:complications* / Q000473:pathology; D014048:Tolonium Chloride; D014603:Uveal Diseases / Q000150:complications* / Q000473:pathology
D000682:Amyloid; D004396:Coloring Agents; D014048:Tolonium Chloride; D003224:Congo Red
Morfologicheskie osobennosti starcheskogo i vtorichnogo amiloidoza raduzhki i sklery u bol'nykh glaukomoĭ.