Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain.
An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.
Lee
H R
HR
Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
Kim
J H
JH
Uhm
H D
HD
Ahn
J B
JB
Rha
S Y
SY
Cho
J Y
JY
Lee
J I
JI
Lee
K H
KH
Chung
H C
HC
Roh
J K
JK
Min
J S
JS
Lee
K S
KS
Shin
D H
DH
Kim
B S
BS
Hong
S W
SW
Choi
J H
JH
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis
D018719:Erb-b2 Receptor Tyrosine Kinases