title: Petrous carotid canal stenosis in malignant osteopetrosis: CT documentation with MR angiographic correlation.
abstract: OBJECTIVE
  To study the association between petrous carotid canal (PCC) and internal carotid artery (ICA) stenoses in patients with malignant osteopetrosis.
  
  
  METHODS
  Mean and minimum PCC diameters obtained from cranial computed tomographic (CT) scans in 20 patients were compared with similar measurements in 52 control subjects. ICA caliber, evaluated with magnetic resonance (MR) arteriography, was correlated with age and PCC dimensions.
  
  
  RESULTS
  There was a statistically significant difference between patient and control PCC diameters. There was a strong positive correlation between age and PCC diameter in the control subjects, but only a weakly positive correlation in the patients. One or both ICAs were stenotic on all patient MR arteriograms. MR angiographic stenosis grade correlated positively with age but not with PCC diameters.
  
  
  CONCLUSIONS
  PCC and ICA stenoses occur frequently in patients with malignant osteopetrosis. Bony overgrowth or a "persistent fetal state" may produce the PPC stenoses. The findings do not support progressive PCC narrowing in these patients.
authors.affiliation: Department of Diagnostic Radiology, Medical University of South Carolina, Charleston, SC 29425-0720, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Curé
authors.forename: L L
authors.initials: LL
authors.lastname: Key
authors.forename: L
authors.initials: L
authors.lastname: Shankar
authors.forename: A J
authors.initials: AJ
authors.lastname: Gross
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000473:pathology; D016893:Carotid Stenosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D018810:Magnetic Resonance Angiography; D008297:Male; D010022:Osteopetrosis / Q000150:complications* / Q000235:genetics; D010579:Petrous Bone / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed