Circadian rhythm in the Ca(2+)-inhibitable adenylyl activity of the rat striatum.
In the present study, we demonstrate that the Ca(2+)-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca(2+)-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca(2+)-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.
Chern
Y
Y
Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC. bmychern@ccvax.sinica.edu.tw
Lee
E H
EH
Lai
H L
HL
Wang
H L
HL
Lee
Y C
YC
Ching
Y H
YH
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002110:Caffeine / Q000031:analogs & derivatives / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002940:Circadian Rhythm / Q000502:physiology*; D005576:Colforsin / Q000494:pharmacology; D003342:Corpus Striatum / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D006153:Guanosine Diphosphate / Q000494:pharmacology; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017207:Rats, Sprague-Dawley
D000067956:Adenylyl Cyclase Inhibitors; D007527:Isoenzymes; D010627:Phenethylamines; D058906:Purinergic P1 Receptor Agonists; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D006153:Guanosine Diphosphate; C081320:8-(3-chlorostyryl)caffeine; D005576:Colforsin; D002110:Caffeine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000241:Adenosine; D002118:Calcium