Effect of M-711 on experimental asthma in rats.
We experimentally demonstrated the anti-asthmatic effects of M-711, the dry extract of a Chinese herb medicine called Mokuboi-to, using the rat model of allergic asthma. Allergic asthma was induced by the antigen-antibody reaction in the rats and they showed anaphylactic symptoms accompanied with hypotension and depression of respiratory function. More than 20 mg/kg body weight of M-711 was effective in relieving the asthmatic symptoms like methylephedrine. It could lessened the suppress of respiration and provided a good improvement. It also reduced a drop of the blood pressure and improved it quickly. Its ingredients alone were much less effective than M-711 as the total. Those data suggested that M-711 was effective for alleviating allergic asthma in the present study and that its action was provided by interaction of all ingredient raw herbs of M-711.
Shichinohe
K
K
Department of Laboratory Animal Science, Nippon Medical School, Tokyo.
Shimizu
M
M
Kurokawa
K
K
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D001794:Blood Pressure / Q000187:drug effects; D001991:Bronchitis / Q000662:veterinary; D002133:Calcium Sulfate; D002935:Cinnamomum zeylanicum; D004283:Dog Diseases; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006967:Hypersensitivity / Q000503:physiopathology / Q000628:therapy*; D008516:Medicine, Chinese Traditional; D010047:Ovalbumin / Q000276:immunology; D005894:Panax; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D012129:Respiratory Function Tests; D013997:Time Factors
D018927:Anti-Asthmatic Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C099755:moku-boi-to; D010047:Ovalbumin; D002133:Calcium Sulfate