title: [Electron microscopic changes in the liver of patients with calculosis of the extrahepatic bile ducts].
abstract: Thirty-four patients, operated for calculosis of extrahepatic bile ducts with obstructive jaundice, are studied. They are divided in two groups according to cholestasis duration-10 and 20 days respectively. Material from liver tissue, taken intraoperatively, is investigated light-and electron-microscopically. The statistical analysis shows a significant increase in cell count in either group, as compared to controls (2.0-controls, 4.2-group one, and 6.2-group two; P < 0.05). There is electron microscope evidence of perisinusoidal fibrosis periportally, ito cell's fibroblastic transformation, and collagenogenesis phase II and III. In group one fibrogenesis is moderate, and in group two-markedly expressed. It is established that parallel to increase in cholestasis duration, fibrogenesis in zone 1 and 2 of the liver lobule intensifies. This explains the necessity of undertaking early surgical intervention.
authors.forename: M
authors.initials: M
authors.lastname: Gŭlŭbova
authors.forename: Kh
authors.initials: Kh
authors.lastname: Stoianov
mesh_terms: D001649:Bile Duct Diseases / Q000097:blood / Q000473:pathology / Q000601:surgery; D017734:Bile Ducts, Extrahepatic / Q000648:ultrastructure*; D001663:Bilirubin / Q000097:blood; D001706:Biopsy; D002769:Cholelithiasis / Q000097:blood / Q000473:pathology* / Q000601:surgery; D002908:Chronic Disease; D005355:Fibrosis; D006801:Humans; D008099:Liver / Q000648:ultrastructure*; D008854:Microscopy, Electron; D013997:Time Factors
chemical_list: D001663:Bilirubin
vernacular_title: Elektronnomikroskopski promeni v cherniia drob pri bolni s kalkuloza na ekstrakhepatalnite zhlŭchni pŭtishta.