title: Gene transfer and amplification in CHO cells. Efficient methods for maximizing specific productivity and assessment of genetic consequences.
authors.affiliation: Genentech Inc., Process Sciences, South San Francisco, California 94080, USA.
authors.forename: F M
authors.initials: FM
authors.lastname: Wurm
authors.forename: A
authors.initials: A
authors.lastname: Johnson
authors.forename: T
authors.initials: T
authors.lastname: Ryll
authors.forename: C
authors.initials: C
authors.lastname: Köhne
authors.forename: H
authors.initials: H
authors.lastname: Scherthan
authors.forename: F
authors.initials: F
authors.lastname: Glaab
authors.forename: Y S
authors.initials: YS
authors.lastname: Lie
authors.forename: C J
authors.initials: CJ
authors.lastname: Petropoulos
authors.forename: W R
authors.initials: WR
authors.lastname: Arathoon
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D007074:Immunoglobulin G / Q000096:biosynthesis; D008727:Methotrexate / Q000494:pharmacology; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000096:biosynthesis*; D012190:Retroviridae; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis / Q000235:genetics; D014162:Transfection / Q000379:methods*
chemical_list: D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate