[Clinicopharmacological case report (3). Drug-induced angioedema].
We report the case of a patient with an angioedema during therapy with enalapril and tramadol. The most likely cause of the adverse effect if the ACE-inhibitor enalapril. A rechallenge with the ACE-inhibitor is dangerous and should not be performed. Because of its potential risks, further treatment with ACE-inhibitors should be avoided in all patients with ACE-inhibitor-induced angioedema. Possible therapeutic alternatives include diuretics, beta-blocking agents, calcium antagonists and also angiotensin II receptor antagonists.
Kind
B
B
Abteilung Klinische Pharmakologie und Toxikologie, Departement Innere Medizin, Universitätsspital Zürich.
Fattinger
K
K
Krähenbühl
S
S
Meier-Abt
P J
PJ
D000701:Analgesics, Opioid / Q000009:adverse effects; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects; D004656:Enalapril / Q000009:adverse effects*; D006801:Humans; D008297:Male; D014147:Tramadol / Q000009:adverse effects
D000701:Analgesics, Opioid; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D014147:Tramadol; D004656:Enalapril
Der klinisch-pharmakologische Fall (3). Medikamentös bedingtes Angioödem.