[Effects of amosulalol hydrochloride on intraocular pressure and aqueous humor dynamics in the rabbit eye].
The effects of amosulalol, which blocks alpha 1 adrenoceptors selectively and beta receptors nonselectively almost to the same extent, on intraocular pressure (IOP) and aqueous humor dynamics were studied in pigmented rabbits. Administration of topical amosulalol (0.5%) resulted in a significant difference in IOP between the treated and the contralateral eyes from 0.5 to 6 hours, and the maximum IOP reduction, 6.0 +/- 0.4 mmHg (mean +/- standard error), was observed at 2 hours after administration. Aqueous humor dynamics measurements (mean +/- standard error) in the amosulalol (0.5%)-treated and the contralateral eyes revealed that total outflow facility determined by the two-level constant pressure perfusion method was not significantly different, 0.14 +/- 0.01 and 0.12 +/- 0.01 microliter/min/mmHg, respectively; the aqueous flow measurements determined by fluorophotometry were 3.0 +/- 0.1 and 3.4 +/- 0.2 microliters/min, respectively (p < 0.05, -11%); the uveoscleral outflow measurements determined by the fluorescein isothiocyanate-dextran perfusion method were 0.53 +/- 0.04 and 0.46 +/- 0.04 microliter/min, respectively (p < 0.05, +15%). In conclusion, amosulalol lowers the IOP by inhibiting aqueous production and increasing uveoscleral outflow.
Taniguchi
T
T
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Deguchi
T
T
Ogawa
T
T
Kitazawa
Y
Y
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D004983:Ethanolamines / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D011817:Rabbits; D000096926:Benzenesulfonamides
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; C032473:amosulalol; D000096926:Benzenesulfonamides