Metabolic problems in recipients of liver transplants.
We analyzed the metabolic problems in recipients of liver transplants. Immunosuppression consisted of cyclosporine, steroids and azathioprine. With a mean follow up of 3.5 yr, 37% of 71 recipients were rendered permanently diabetic and hyperlipidemic. Recipients who developed posttransplant diabetes had higher cholesterol levels and proteinuria, but decreased creatinine clearance. Transplant recipients who developed posttransplant hyperlipidemia had greater proteinuria, but their sugars and creatinine clearance were comparable to those who did not have hyperlipidemia. The most significant factor responsible for these metabolic complications was the total dosage of prednisone and cyclosporine. There was no effect of risk antigens on the development of diabetes.
Jindal
R M
RM
Division of Transplantation, Indiana University School of Medicine, Indianpolis 46202, USA.
Sidner
R A
RA
Hughes
D
D
Pescovitz
M D
MD
Leapman
S B
SB
Milgrom
M L
ML
Lumeng
L
L
Filo
R S
RS
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D050260:Carbohydrate Metabolism; D003404:Creatinine / Q000378:metabolism; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy / Q000188:drug therapy / Q000209:etiology*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007328:Insulin / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D011507:Proteinuria / Q000209:etiology
D005938:Glucocorticoids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007166:Immunosuppressive Agents; D007328:Insulin; D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone