title: Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells.
abstract: The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3-dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.
authors.affiliation: Division of Hematology/Oncology, Indiana University Medical Center, Indianapolis 46202, USA.
authors.forename: R
authors.initials: R
authors.lastname: Hromas
authors.forename: S
authors.initials: S
authors.lastname: Boswell
authors.forename: R N
authors.initials: RN
authors.lastname: Shen
authors.forename: G
authors.initials: G
authors.lastname: Burgess
authors.forename: A
authors.initials: A
authors.lastname: Davidson
authors.forename: K
authors.initials: K
authors.lastname: Cornetta
authors.forename: J
authors.initials: J
authors.lastname: Sutton
authors.forename: K
authors.initials: K
authors.lastname: Robertson
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001853:Bone Marrow / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology*; D051741:Kruppel-Like Transcription Factors; D051379:Mice; D009368:Neoplasm Transplantation; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D007377:Interleukin-3; D051741:Kruppel-Like Transcription Factors; C085969:MZF1 protein, human; C490095:Mzf1 protein, mouse; D014157:Transcription Factors