Expression of CD26/dipeptidyl peptidase IV in adult T cell leukemia/lymphoma (ATLL).
The association of CD26/dipeptidyl peptidase IV (DPPIV) and human T lymphotropic virus type I (HTLV-I) was studied by two approaches. First, we examined the expression of CD26 in peripheral blood mononuclear cells (PBMC) from the patients with adult T cell leukemia/lymphoma (ATLL), an HTLV-I-related malignancy. The expression of CD26 on the surface of PBMC was decreased in all 20 patients with ATLL compared with those from normal individuals (P < 0.01) and the expression of the CD26 gene transcript was not detectable in seven out of eight patients with ATLL. Then we compared the quantity of viral DNA in CD26-negative (CD26-) and CD26-positive (CD26+) cells obtained from 17 HTLV-I healthy carries by using a polymerase chain reaction method. The CD26-cells had a higher copy number of viral DNA than CD26+ cells. These findings indicate that HTLV-I has in vivo tropism to CD26- cells, suggesting that some phenotypes of ATLL cells reflect the in vivo cellular tropism of HTLV-I.
Kondo
S
S
Blood Transfusion Division, Miyazaki Medical College, Japan.
Kotani
T
T
Tamura
K
K
Aratake
Y
Y
Uno
H
H
Tsubouchi
H
H
Inoue
S
S
Niho
Y
Y
Ohtaki
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D015152:Blotting, Northern; D002353:Carrier State; D017931:DNA Primers; D004279:DNA, Viral; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics*; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology; D006801:Humans; D016130:Immunophenotyping; D007564:Japan / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000201:enzymology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics
D017931:DNA Primers; D004279:DNA, Viral; D012333:RNA, Messenger; D018819:Dipeptidyl Peptidase 4