title: Localization of the human vascular endothelial growth factor gene, VEGF, at chromosome 6p12.
abstract: Using overlapping cosmids representing the vascular endothelial growth factor (VEGF) locus, the VEGF gene was mapped by fluorescence in situ hybridization to chromosome 6p12. This localization permits linkage analysis and the identification of gene interaction in the region, as well as alterations of the VEGF structure or expression in cancer cells with chromosome abnormalities.
authors.affiliation: Biological Carcinogenesis and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Wei
authors.forename: N C
authors.initials: NC
authors.lastname: Popescu
authors.forename: M I
authors.initials: MI
authors.lastname: Lerman
authors.forename: M J
authors.initials: MJ
authors.lastname: Merrill
authors.forename: D B
authors.initials: DB
authors.lastname: Zimonjic
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D003360:Cosmids; D016228:Endothelial Growth Factors / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008222:Lymphokines / Q000235:genetics*; D008969:Molecular Sequence Data; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors