Pseudouridine and 1-ribosylpyridin-4-one-3-carboxamide (PCNR) serum concentrations in human immunodeficiency virus type 1-infected patients are independent predictors for AIDS progression.
A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (> 3.77 nmol/mL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29-6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and beta 2-microglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters.
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Dipartimento di Biochimica e Biotecnologie Mediche, Università degli Studi di Napoli, Federico II, Italy.
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D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000821:virology; D000328:Adult; D016516:CD4-CD8 Ratio; D018450:Disease Progression; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011560:Pseudouridine / Q000097:blood*; D011728:Pyridones / Q000097:blood; D012263:Ribonucleosides / Q000097:blood*; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000378:metabolism
D011728:Pyridones; D012263:Ribonucleosides; D001613:beta 2-Microglobulin; D011560:Pseudouridine; C020933:1 beta-D-ribofuranosylpyridin-4-one 3-carboxamide