title: Occlusion of the neonatal patent ductus arteriosus with a simple retrievable device: a feasibility study.
abstract: OBJECTIVE
  To examine the feasibility of transvenous placement of a new memory-shaped, small, retrievable coil that has a smaller-caliber delivery system than currently available devices, for closure of the patent ductus arteriosus (PDA).
  
  
  METHODS
  Through 4 or 5 Fr vascular sheaths and 4 or 5 Fr end-hold catheters, the coils were delivered and placed in piglets (n = 10) with PDA. The coils were made from 0.018" (0.46 mm) or 0.028" (0.71 mm) stainless steel guidewire. Mounted for delivery, the new device has the appearance of a conventional guidewire. This neonatal PDA model was created without major surgery or drugs by stenting the ductus arteriosus.
  
  
  RESULTS
  The memory-shaped coils were easily delivered. Coils not optimally placed were retrieved and repositioned. Occlusion of the ductus arteriosus as early as a half-hour after delivery was shown angiographically and confirmed by histopathology.
  
  
  CONCLUSIONS
  This new, small-caliber, simple device was found to be effective for closure of the PDA in this animal model. Longer-term observations are needed.
authors.affiliation: Department of Cardiology, Children's Hospital, University of Bonn, Adenauerallee 119, D-5300, Bonn 1, Germany.
authors.forename: M B
authors.initials: MB
authors.lastname: Neuss
authors.forename: J Y
authors.initials: JY
authors.lastname: Coe
authors.forename: F
authors.initials: F
authors.lastname: Tio
authors.forename: T P
authors.initials: TP
authors.lastname: Le
authors.forename: R
authors.initials: R
authors.lastname: Grabitz
authors.forename: D A
authors.initials: DA
authors.lastname: Redel
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D005240:Feasibility Studies; D011859:Radiography; D013193:Stainless Steel; D013552:Swine
chemical_list: D013193:Stainless Steel