Biological effects of dietary arachidonic acid. Introduction.
The intent of this symposium is to assemble current knowledge of the role of arachidonic acid (AA) in the diet to provide a conceptual and mechanistic framework for future research. The principal focus is on the varied biological effects of dietary AA, including opposing effects of n-3 and n-6 polyunsaturated fatty acids (PUFA); regulation of n-6 PUFA metabolism, eicosanoid synthesis and gene expression; the importance of AA in infant nutrition and the contemporary Western diet in general; and the effects of AA on tumor promotion. Through its myriad actions and remarkably ubiquitous presence in cells, AA can be argued to affect every cell of the body. Although the varied molecular events associated with the metabolism of AA have been subjects of intense investigation, the ability of AA in the diet to alter AA levels in cellular membranes is poorly described and is thus the focus of this symposium.
German
J B
JB
Department of Food Science and Technology, University of California, Davis CA 95616, USA.
Dillard
C J
CJ
Whelan
J
J
D016718:Arachidonic Acid / Q000493:pharmacokinetics / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D006128:Growth; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D009369:Neoplasms / Q000209:etiology
D004042:Dietary Fats, Unsaturated; D016718:Arachidonic Acid