[Experimental study of the possibility of emergency prophylaxis of Bolivian hemorrhagic fever].
Describes changes in nonspecific immunity parameters (interferon, interleukin-1, tumor necrosis factor, and natural killers) in the course of experimental Bolivian fever (Machupo virus). Changes of these parameters were followed up after urgent prophylactic injections of Ridostin and specific gamma-globulin to infected animals. The possibility of treatment of experimental Machupo fever by intranasal administration of interferon inductor Ridostin has been demonstrated.
Kaliberov
S A
SA
Ignat'ev
G M
GM
Pereboeva
L A
LA
Kashentseva
E A
EA
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006478:Hemorrhagic Fever, American / Q000276:immunology / Q000517:prevention & control*; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012331:RNA, Fungal / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D014709:Vero Cells; D005719:gamma-Globulins / Q000494:pharmacology
D000998:Antiviral Agents; D007369:Interferon Inducers; D007375:Interleukin-1; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D014409:Tumor Necrosis Factor-alpha; D005719:gamma-Globulins; C076741:ridostin; D007372:Interferons
Eksperimental'noe izuchenie vozmozhnosti ékstrennoĭ profilaktiki Boliviĭskoĭ gemorragicheskoĭ likhoradki.