Prevention of vascular graft infection by sisomicin incorporated into fibrin glue.
To examine the efficacy of sisomicin (SISO) incorporated into fibrin glue (FG) for the prevention of graft infection in animal models, the susceptibility to infection of Dacron grafts (control) and SISO-FG Dacron grafts following the inoculation of Staphylococcus aureus or S. epidermidis was compared. The results showed that SISO-FG Dacron grafts displayed resistance to graft infection.
Yamamura
K
K
Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Sakurai
T
T
Yano
K
K
Osada
T
T
Nabeshima
T
T
D000818:Animals; D001807:Blood Vessel Prosthesis / Q000009:adverse effects / Q000379:methods*; D015169:Colony Count, Microbial; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D051381:Rats; D012853:Sisomicin / Q000008:administration & dosage / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis
D015718:Fibrin Tissue Adhesive; D012853:Sisomicin