title: Four-year outcome for cognitive behavioral treatment of residual symptoms in major depression.
abstract: OBJECTIVE
  The authors' goal was to determine whether cognitive behavioral treatment of residual symptoms of depression might have a significant effect on relapse rate.
  
  
  METHODS
  In an earlier study, 40 patients with primary major depressive disorder who had been successfully treated with antidepressant drugs were randomly assigned to either cognitive behavioral treatment of residual symptoms or standard clinical management. In both types of treatment, antidepressant drugs were gradually tapered and discontinued. In this study, a 4-year follow-up assessment was performed.
  
  
  RESULTS
  Cognitive behavioral treatment resulted in a substantially lower relapse rate (35%) than did clinical management (70%).
  
  
  CONCLUSIONS
  Cognitive behavioral treatment of residual symptoms reduces the risk of relapse in depressed patients, probably by affecting the progression of residual symptoms to prodromes of relapse.
authors.affiliation: Department of Psychology, University of Bologna, Italy.
authors.forename: G A
authors.initials: GA
authors.lastname: Fava
authors.forename: S
authors.initials: S
authors.lastname: Grandi
authors.forename: M
authors.initials: M
authors.lastname: Zielezny
authors.forename: C
authors.initials: C
authors.lastname: Rafanelli
authors.forename: R
authors.initials: R
authors.lastname: Canestrari
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage; D015928:Cognitive Behavioral Therapy; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D012008:Recurrence; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents