title: Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury.
abstract: Cefuroxime levels were measured in cerebrospinal fluid (CSF) and serum of four patients with traumatic brain injury following the implantation of intraventricular catheters. The levels ranged from 0.15 to 2.03 micrograms/mL in CSF and from 1.8 to 66.9 micrograms/mL in serum. No ventriculostomy related infections were detected.
authors.affiliation: Department of Surgery, University of Zürich, Medical School, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Kossmann
authors.forename: V
authors.initials: V
authors.lastname: Hans
authors.forename: R
authors.initials: R
authors.lastname: Stocker
authors.forename: H G
authors.initials: HG
authors.lastname: Imhof
authors.forename: B
authors.initials: B
authors.lastname: Joos
authors.forename: O
authors.initials: O
authors.lastname: Trentz
authors.forename: M C
authors.initials: MC
authors.lastname: Morganti-Kossmann
mesh_terms: D000293:Adolescent; D000328:Adult; D019072:Antibiotic Prophylaxis; D001812:Blood-Brain Barrier; D001930:Brain Injuries / Q000134:cerebrospinal fluid*; D002444:Cefuroxime / Q000134:cerebrospinal fluid*; D002511:Cephalosporins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime