Increased numbers of interleukin-12-producing cells in human tuberculosis.
Numbers of interleukin-12 (IL-12) producing cells were quantitated in the peripheral blood of healthy donors and tuberculosis patients by the ELISPOT assay. We observed that (i) stimulation with mycobacteria increases numbers of IL-12 producers from healthy donors and (ii) tuberculosis patients have larger numbers of IL-12 producers than healthy donors. Our data emphasize the importance of Il-12 in immunity to tuberculosis.
Munk
M E
ME
Department of Immunology, University of Ulm, Germany.
Mayer
P
P
Anding
P
P
Feldmann
K
K
Kaufmann
S H
SH
D000328:Adult; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D018664:Interleukin-12 / Q000096:biosynthesis*; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
D018664:Interleukin-12; D007371:Interferon-gamma