Fluconazole failure in two cases of disseminated candidosis.
Amphotericin B has been the standard treatment of disseminated candidosis although the less toxic fluconazole tends to be used more frequently. In a recent report, no significant difference in the efficacy of candidaemia treatment was observed between fluconazole and amphotericin B. However, we report on 2 cases of invasive candidosis where fluconazole failed to eradicate Candida albicans although the isolates were susceptible to fluconazole in vitro. Pulsed-field gel electrophoresis was used to confirm the persistence of the same C. albicans strain after therapy failure in both patients.
Jahnson
L
L
Department of Infectious Diseases, Orebro Medical Center, Sweden.
Chryssanthou
E
E
Petrini
B
B
Vikerfors
T
T
D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017211:Treatment Failure
D000935:Antifungal Agents; D015725:Fluconazole