Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.
We examined the distribution of several relevant growth factors in gamma-interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-alpha, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-alpha, and the EGF receptor were observed in acini undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.
Arnush
M
M
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA.
Gu
D
D
Baugh
C
C
Sawyer
S P
SP
Mroczkowski
B
B
Krahl
T
T
Sarvetnick
N
N
D000818:Animals; D006133:Growth Substances / Q000737:chemistry / Q000502:physiology*; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D010179:Pancreas / Q000737:chemistry* / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects / Q000235:genetics*
D006133:Growth Substances; D007371:Interferon-gamma