A new method using neuromagnetic stimulation to measure conduction time within the cauda equina.
Using principles derived from electric field measurements and studies of phrenic nerve in vitro, neuromagnetic stimuli in humans were predicted to excite selective low threshold sites in proximal and distal cauda equina. Physical models, in which induced electric fields were recorded in a segment of human lumbosacral spine immersed in a saline filled tank, supported this prediction. Conclusions from the model were tested and confirmed in normal human subjects. Ipsilateral motor evoked potentials were elicited in lower limb muscles and striated sphincters by magnetic coil (MC) stimulation of both proximal and distal cauda equina. Over proximal cauda equina a vertically oriented MC junction and cranially directed induced current elicited a newly identified compound muscle action potential (CMAP). The F response latency and lack of attenuation when the target muscle was vibrated suggest that the proximal response is a directly elicited M response arising near or at the rootlet exit zone of the conus medullaris. Over distal cauda equina, lumbar roots were optimally excited by a horizontally oriented MC junction, and sacral roots by an approximately vertically oriented MC junction, eliciting CMAPs with similar appearance but shorter latency consistent with the known intrathecal lengths of the lower lumbar and sacral nerve roots. The induced current was usually most effective when directed towards the spinal fluid filled thecal sac. Normal subjects showed stable CMAP onset latencies elicited at proximal and distal cauda equina despite wide variation in amplitude. Thus, cauda equina conduction time can be directly calculated. This new method may improve the detection and classification of peripheral neuropathies affecting lower limbs and striated sphincters.
Maccabee
P J
PJ
Department of Neurology, State University of New York, Health Science Center at Brooklyn 11203, USA.
Lipitz
M E
ME
Desudchit
T
T
Golub
R W
RW
Nitti
V W
VW
Bania
J P
JP
Willer
J A
JA
Cracco
R Q
RQ
Cadwell
J
J
Hotson
G C
GC
Eberle
L P
LP
Amassian
V E
VE
D000328:Adult; D002420:Cauda Equina / Q000502:physiology*; D004558:Electric Stimulation; D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D008161:Lumbosacral Region / Q000294:innervation / Q000502:physiology; D008280:Magnetics; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology; D012447:Sacrum / Q000294:innervation / Q000502:physiology; D013115:Spinal Canal / Q000502:physiology; D013126:Spinal Nerve Roots / Q000502:physiology; D013848:Thigh / Q000294:innervation / Q000502:physiology; D013997:Time Factors