title: Induction of differential T-helper-cell responses in mice infected with variants of the parasitic nematode Trichuris muris.
abstract: The resistance or susceptibility of mice to infection with the intestinal nematode parasite Trichuris muris is closely correlated with polarization of T helper (Th) cell responses to the type 2 (Th2) or type 1 (Th1) subset. Comparison of infections with three isolates of T. muris (E/K, E/N, and S) in three inbred strains of mice (CBA, C57BL/10, and B10.BR) has shown that host Th response phenotype can be parasite determined. Although the mouse strains used show genetically determined variation in ability to respond to T. muris (CBA > C57BL/10 > B10.BR), the speed of worm expulsion in a given strain depended upon the isolate used for infection (E/K > E/N > S). The two isolates that induced the most effective resistance (E/K and E/N) elicited parasite-specific host antibody responses that were dominated by immunoglobulin G1 (IgG1), and antigen-stimulated T cells from infected mice released interleukin-5 in vitro. With the isolate that induced the least host resistance (S), the dominant antibody response was IgG2a, and T cells released gamma interferon in vitro. These data show clearly that parasite variant-specific factors play a major role in Th subset polarization during infection.
authors.affiliation: Department of Life Science, University of Nottingham, United Kingdom.
authors.forename: T
authors.initials: T
authors.lastname: Bellaby
authors.forename: K
authors.initials: K
authors.lastname: Robinson
authors.forename: D
authors.initials: D
authors.lastname: Wakelin
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D016207:Cytokines / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014257:Trichuriasis / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D016207:Cytokines