[Ductal carcinoma in situ in dynamic MR-mammography at 1.5 T].
OBJECTIVE
To define the value of contrast-enhanced MR mammography in ductal carcinoma in situ (DCIS).


METHODS
In a group of 35 patients with DCIS, the results of MR imaging were compared to histopathology and immunohistochemistry in a retrospective study.


RESULTS
In 35 patients with DCIS, a signal enhancement was found in 25 cases (72%). In 15 of these cases, the signal time curve was typical for malignancy. The other 10 patients had non-specific signal curves. Six of 35 patients (11%) had no enhancement within the tumour region. Four of 35 patients (11%) had bilateral diffuse signal increase, and regions of DCIS could not be identified clearly. Three DCIS were visualised exclusively by MR mammography. The configuration of signal enhancement was sharp (32%), unsharp (48%) or dendritic (20%). DCIS of the comedo type showed a significantly higher enhancement than the non-comedo type. A significant correlation between the grade of vascularisation in immunohistochemistry and signal enhancement in MR mammography could not be demonstrated.


CONCLUSIONS
Dynamic MR mammography does not reliably visualise DCIS.
Fischer
U
U
Abteilung Röntgendiagnostik, Georg-August-Universität Göttingen.
Westerhof
J P
JP
Brinck
U
U
Korabiowska
M
M
Schauer
A
A
Grabbe
E
E
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001940:Breast / Q000098:blood supply / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002278:Carcinoma in Situ / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000473:pathology; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D012189:Retrospective Studies
D014408:Biomarkers, Tumor; D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA
Das duktale In-situ-Karzinom in der dynamischen MR-Mammographie bei 1,5 T.