Serial positron emission tomography imaging of changes in amino acid metabolism in low grade astrocytoma after radio- and chemotherapy-- Case report.
A 37-year-old male with mixed glioma was treated with combined radio- and chemotherapy. The amino acid metabolism of the tumor site and normal brain was followed by positron emission tomography using [11C]methionine ([11C]Met). The accumulation of [11C]Met in the tumor decreased during therapy and slightly increased 7 months after completion of the therapy, but then decreased markedly. However, computed tomography revealed no notable changes. The contralateral gray matter also showed a gradual decrease of [11C]Met accumulation. These findings indicate that reduction of amino acid metabolism in the tumor continues after radiochemotherapy although neuroimaging reveals no further morphological changes. Such therapy also has long-term effects on normal brain tissue.
Sato
K
K
Department of Neurosurgery, Tohoku University School of Medicine, Sendai.
Kameyama
M
M
Kayama
T
T
Yoshimoto
T
T
Ishiwata
K
K
Ito
M
M
D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000528:radiation effects; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy*; D002250:Carbon Radioisotopes; D003131:Combined Modality Therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008715:Methionine; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D000596:Amino Acids; D002250:Carbon Radioisotopes; C086242:carbon-11 methionine; D008715:Methionine