title: Recombinant bovine somatotropin decreases hepatic amino acid catabolism in female rats.
abstract: The effect of recombinant bovine somatotropin (rbST) on hepatic amino acid catabolism in female rats was investigated. Daily injections of rbST for 5 d decreased liver homogenate lysine alpha-ketoglutarate reductase (EC 1.5.1.8) activity (P < 0.05) and liver homogenate lysine oxidation (P < 0.05) approximately 35%. Liver homogenate methionine and valine oxidation were depressed approximately 20 (P = 0.13) and 35% (P < 0.05), respectively. These data show a decrease in hepatic capacity to oxidize amino acids in rats administered rbST. Whether depressed liver amino acid degrading enzyme activity plays a role in amino acid oxidation in vivo remains to be evaluated.
authors.affiliation: Department of Meat and Animal Science, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Blemings
authors.forename: M J
authors.initials: MJ
authors.lastname: Gahl
authors.forename: T D
authors.initials: TD
authors.lastname: Crenshaw
authors.forename: N J
authors.initials: NJ
authors.lastname: Benevenga
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D012443:Saccharopine Dehydrogenases / Q000378:metabolism; D014633:Valine / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000596:Amino Acids; D011994:Recombinant Proteins; D013006:Growth Hormone; D008715:Methionine; D012443:Saccharopine Dehydrogenases; C029496:saccharopine dehydrogenase (NADP+, lysine-forming); D014633:Valine; D008239:Lysine