title: Effect of low levels of fluoride on calcium uptake by demineralized human enamel.
abstract: The effect of fluoride (ca. 0.1 parts/10(6)) on calcium uptake by enamel was examined under alternating remineralizing and demineralizing conditions. The remineralizing solutions contained either 0, 0.058, 0.104, or 0.138 parts/10(6) fluoride (ex NaF), while the demineralizing solutions contained no added fluoride. During the demineralization periods, calcium loss was similar for all groups. However, during the remineralizing periods, all levels of added fluoride were found to promote calcium uptake. Calcium levels taken up by the artificial lesions were sound to increase with increasing fluoride concentration in solution, and were independent of surface area of exposed enamel. In the absence of fluoride, even under conditions that are considered to be remineralizing, further demineralization took place.
authors.forename: C D
authors.initials: CD
authors.lastname: Gibbs
authors.forename: S E
authors.initials: SE
authors.lastname: Atherton
authors.forename: E
authors.initials: E
authors.lastname: Huntington
authors.forename: R J
authors.initials: RJ
authors.lastname: Lynch
authors.forename: R M
authors.initials: RM
authors.lastname: Duckworth
mesh_terms: D002118:Calcium / Q000032:analysis / Q000493:pharmacokinetics*; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic; D017001:Tooth Demineralization / Q000378:metabolism* / Q000473:pathology; D014089:Tooth Remineralization
chemical_list: D002327:Cariostatic Agents; D012969:Sodium Fluoride; D002118:Calcium