Transcription factors of T and B lymphocytes--basic research and clinical perspectives for gastroenterology.
Tissue specific regulation of gene expression by transcription factors is a fascinating new field in molecular immunology. This review summarizes data on specific regulation of promoters and enhancers by nuclear trans-acting factors in lymphocytes. The structural classes of transcription factors are described and basic methods for detection and analysis of transcription factors are detailed. Furthermore, the most important trans-acting factors of T and B lymphocytes (e.g. NF-kB, NF-AT and STAT families) and their functional importance are described. Several methods for specific down-regulation of transcription factors are shown that may be relevant to treatment of human disease. The data are discussed with regard to their potential clinical relevance for gastroenterology.
Neurath
M F
MF
Medical Clinic, Laboratory of Immunology, University of Mainz.
Meyer zum Büschenfelde
K H
KH
D001402:B-Lymphocytes / Q000276:immunology*; D015536:Down-Regulation / Q000235:genetics; D004742:Enhancer Elements, Genetic / Q000235:genetics; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
D015534:Trans-Activators; D014157:Transcription Factors