Palliation for pancreatic cancer. Feasibility of laparoscopic cholecystojejunostomy and gastrojejunostomy in a porcine model.
BACKGROUND
Although laparoscopy reveals undetected metastases in many patients with pancreatic cancer, most surgeons have chosen to proceed directly with laparotomy in an attempt at resection or for palliation of biliary and gastric outlet obstruction. In an effort to overcome this limitation, this study attempted to determine the feasibility of laparoscopic cholecystojejunostomy and gastrojejunostomy.


METHODS
Under general anesthesia, seven pigs underwent laparoscopic cholecystojejunostomy and gastrojejunostomy using either a hand-sutured or the stapled/sutured technique.


RESULTS
Mean operating time was less with the stapled/sutured vs hand-sutured technique (150 +/- 21 vs 230 +/- 13 min, P < 0.05). All animals recovered completely and there was no change in their weight or liver function tests as a result of the procedure. At sacrifice, all anastomoses were patent, although some were significantly narrowed in these unobstructed animals.


CONCLUSIONS
These results suggest that simultaneous laparoscopic palliation of biliary and gastric outlet obstruction is feasible. We believe these results warrant further study in the clinical setting.
Patel
A G
AG
Departments of Surgery, Sepulveda VAMC, and UCLA School of Medicine, 10833 Leconte Avenue, Los Angeles, CA, USA 90024-6904, USA.
McFadden
D W
DW
Hines
O J
OJ
Reber
H A
HA
Ashley
S W
SW
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D005704:Gallbladder / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000601:surgery*; D011897:Random Allocation; D013270:Stomach / Q000601:surgery*; D013552:Swine