title: Intranasal midazolam better at effecting amnesia after sedation than oral hydroxyzine: a pilot study.
abstract: Providing amnesia about a surgery is a desired side effect of a medication. This study compares anterograde amnesic effects of midazolam with hydroxyzine in children undergoing dental treatment with those drugs plus nitrous oxide, using a recall test. Thirty ASAI children 24-28 months, were shown a Standard-Binet intelligence scale-memory for objects subtest before entering treatment room. Twenty-lone randomly determined children received 3.7 mg/kg hydroxyzine 45 min before treatment or 0.2 mg/kg intranasal midazolam in two succeeding appointments, alternatively. Recall in the 30-subject treatment group was 90%. Recall in the 21-subject treatment group was 71% for hydroxyzine and 29% for midazolam. Midazolam was more effective in creating amnesia than hydroxyzine in this study.
authors.affiliation: Hebrew University--Hadassah School of Dental Medicine, Department of Pediatric Dentistry, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Kupietzky
authors.forename: G
authors.initials: G
authors.lastname: Holan
authors.forename: J
authors.initials: J
authors.lastname: Shapira
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000766:Anesthesia, Dental; D000769:Anesthesia, Inhalation; D002675:Child, Preschool; D016292:Procedural Sedation; D019140:Dental Care for Children; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D008874:Midazolam / Q000008:administration & dosage*; D009609:Nitrous Oxide / Q000008:administration & dosage; D010865:Pilot Projects; D011229:Preanesthetic Medication
chemical_list: D006993:Hypnotics and Sedatives; D006919:Hydroxyzine; D009609:Nitrous Oxide; D008874:Midazolam