Spatial distribution of sex chromosomes and ribosomal genes: a study on human lymphocytes and testicular cells.
The location of the sex chromosomes in relation to the rRNA genes in the nuclei of human lymphocytes and testicular cells was examined. Sex chromosomes were found to be located closer to ribosomal genes than would be expected assuming a random arrangement of these chromosomes with respect to rRNA genes. This proximity could be observed irrespective of the transcriptional activity of ribosomal genes indicating that the chromosomal material and not transcriptional activity is responsible for the intranuclear order of these chromosomes.
Weipoltshammer
K
K
Histologisch-Embryologisches Institut der Universität, Vienna, Austria.
Schöfer
C
C
Almeder
M
M
Sylvester
J
J
Wachtler
F
F
D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure*; D002478:Cells, Cultured; D004275:DNA, Ribosomal / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D012708:Sertoli Cells / Q000648:ultrastructure; D012730:Sex Chromosomes / Q000648:ultrastructure*; D016622:Silver Staining; D013090:Spermatocytes / Q000648:ultrastructure; D013737:Testis / Q000166:cytology*; D014158:Transcription, Genetic; D014960:X Chromosome / Q000648:ultrastructure; D014998:Y Chromosome / Q000648:ultrastructure
D004275:DNA, Ribosomal