Inhibitors of dihydro-orotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs.
Christopherson
R I
RI
Department of Biochemistry, University of Sydney, NSW, Australia.
Williams
N K
NK
Schoettle
S L
SL
Szabados
E
E
Hambley
T W
TW
Manthey
M K
MK
D000495:Allosteric Site; D000582:Amidophosphoribosyltransferase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002256:Carbonic Anhydrases / Q000235:genetics; D006224:Cricetinae; D004080:Dihydroorotase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005492:Folic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D005493:Folic Acid Antagonists / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D009709:Nucleotide Deaminases / Q000037:antagonists & inhibitors*; D017354:Point Mutation; D017386:Sequence Homology, Amino Acid
D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; C010920:dihydrofolate; D005492:Folic Acid; D000582:Amidophosphoribosyltransferase; D004080:Dihydroorotase; D009709:Nucleotide Deaminases; C021436:IMP cyclohydrolase; D002256:Carbonic Anhydrases