Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Atm, the mouse homolog of the human ATM gene defective in ataxia-telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.
Pecker
I
I
Department of Human Genetics, Tel Aviv University, Ramat Aviv, 69978, Israel.
Avraham
K B
KB
Gilbert
D J
DJ
Savitsky
K
K
Rotman
G
G
Harnik
R
R
Fukao
T
T
Schröck
E
E
Hirotsune
S
S
Tagle
D A
DA
Collins
F S
FS
Wynshaw-Boris
A
A
Ried
T
T
Copeland
N G
NG
Jenkins
N A
NA
Shiloh
Y
Y
Ziv
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics*; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D003433:Crosses, Genetic; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins; D005260:Female; D015870:Gene Expression; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics; D009928:Organ Specificity; D017346:Protein Serine-Threonine Kinases; D011506:Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017385:Sequence Homology; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D011506:Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C576325:Atm protein, mouse; D017346:Protein Serine-Threonine Kinases