title: Dose titration of moxidectin oral gel against migrating Strongylus vulgaris and Parascaris equorum larvae in pony foals.
abstract: Moxidectin was tested for efficacy in ponies against experimental infections of 56 day Strongylus vulgaris larvae and 11 day Parascaris equorum larvae. Three dosages of moxidectin were tested: 300 micrograms per kg live body weight, 400 micrograms per kg, and 500 micrograms per kg, and the vehicle served as control. Ponies were first infected with 600 S. vulgaris third-stage larvae (L3) on Experiment Day 0 and then with 3000 embryonated P. equorum eggs on Day 45. Moxidectin treatments were administered on Day 56 and necropsy examinations were performed on Day 91. Strongylus vulgaris fourth-stage (L4) and fifth-stage (L5) larvae were recovered at necropsy from the control ponies, in dissections of the cranial mesenteric artery and its branches (L4 and L5), and recovered from nodules in the wall of the cecum and ventral colon (L5). Parascaris equorum larvae were recovered from the small intestine of control ponies. Moxidectin was highly efficacious against S. vulgaris L4 and L5 at all three doses tested (99.6-100%), and appeared to be equally efficacious against P. equorum larvae (100%); however, control ponies had low levels of P. equorum infections compared to previous experimental infections performed using identical methods. This suggests that the prior S. vulgaris infection on Day 0 may have influenced the subsequent experimental P. equorum infection on Day 45 and contributed to the lower recovery.
authors.affiliation: Department of Veterinary Microbiology and Parasitology, Louisiana State University, Baton Rouge 70803, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Monahan
authors.forename: M R
authors.initials: MR
authors.lastname: Chapman
authors.forename: H W
authors.initials: HW
authors.lastname: Taylor
authors.forename: D D
authors.initials: DD
authors.lastname: French
authors.forename: T R
authors.initials: TR
authors.lastname: Klei
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000831:Animals, Newborn; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents; D017191:Ascaridida Infections / Q000188:drug therapy / Q000662:veterinary*; D001199:Ascaridoidea / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D018397:Equidae; D005782:Gels; D007814:Larva; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D017206:Strongylida Infections / Q000188:drug therapy / Q000662:veterinary*; D013323:Strongylus / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D005782:Gels; D018942:Macrolides; C027837:moxidectin