title: Doppler echocardiographic findings of indomethacin-induced occlusion of the fetal ductus arteriosus.
abstract: We present an unusual case of indomethacin-induced occlusion of the fetal ductus arteriosus, which occurred in one of twins. In fetal echocardiography, the characteristic findings, a to and fro regurgitation pattern at pulmonary valve and postvalvular dilation of the main pulmonary artery, were obtained in addition to right ventricular dilation and hypertrophy, tricuspid regurgitation, right atrium dilation, and pericardial effusion. This fetus developed fetal distress and was delivered by an emergency cesarean section at 35 weeks' gestation. We suggest that these fetal echocardiographic findings may be the end-stage signs of the fetal ductal occlusion as well as the signs for emergent delivery.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: A
authors.initials: A
authors.lastname: Ishida
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Tsuda
authors.forename: G
authors.initials: G
authors.lastname: Takada
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002585:Cesarean Section; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging; D004200:Diseases in Twins / Q000175:diagnosis / Q000209:etiology; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging / Q000187:drug effects*; D015150:Echocardiography, Doppler; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006325:Heart Atria / Q000000981:diagnostic imaging; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging; D007213:Indomethacin / Q000009:adverse effects*; D010490:Pericardial Effusion / Q000000981:diagnostic imaging; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011665:Pulmonary Valve Insufficiency / Q000000981:diagnostic imaging; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin