The absence of a B allele in acquired B blood group phenotype confirmed by a DNA based genotyping method.
A case of an 87 year old woman with carcinomatous sigmoid colon, found to be of group A1 with acquired B status, is reported. The acquired B phenotype was confirmed by the absence of a B allele in the patient using denaturing gradient gel electrophoresis of a DNA fragment amplified from the ABO locus by the polymerase chain reaction.
Yip
S P
SP
Department of Health Science, Hong Kong Polytechnic University, Kowloon.
Choy
W L
WL
Chan
C W
CW
Choi
C H
CH
D000017:ABO Blood-Group System / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012811:Sigmoid Neoplasms / Q000097:blood*
D000017:ABO Blood-Group System