[LDL apheresis using a double filtration technique. Results after a 6-to-12 month follow-up in patients with refractory hyperlipemia and ischemic heart disease].
METHODS
Five patients with a family history of hypercholesterolemia were treated for one year with double filtered technique of LDL-apheresis: heterozygotic in four patient and homozygotic in one. All patients presented documented cardiovascular disease and had been treated unsuccessfully with lipid lowering drugs.


RESULTS
Plasmatic cholesterol was significantly reduced from 463.8 +/- 60.9 mg/dl to 326.36 +/- 36 mg/dl at 6 months after treatment and 347.56 +/- 68.1 mg/dl at 12 months (p < 0.05). LDL was also reduced from 407.92 +/- 69.39 mg/dl to 294.04 +/- 62.02 mg/dl and 296.6 +/- 82.42 mg/dl respectively (p < 0.05) and Apo B was reduced from 291.84 +/- 28.97 mg/dl to 224.5 +/- 47.11 mg/dl at 6 and 12 months respectively, without significant modifications of other lipidic parameters and without adverse events.


CONCLUSIONS
LDL-apheresis is a therapeutic approach effective in the reduction of total plasmatic cholesterol, in conjunction with to LDL and APO B in patients refractory to lipid lowering agents.
Rubio Sanz
R
R
Servicio de Cardiologia, Hospital General Universitario Gregorio Marañón, Madrid.
Anaya
F
F
López-Sendón
J L
JL
López de Sa
E
E
Muñoz
H
H
García
E
E
Delcán
J L
JL
D000328:Adult; D001781:Blood Component Removal / Q000379:methods; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000150:complications*; D005260:Female; D005374:Filtration; D005500:Follow-Up Studies; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010375:Pedigree; D013997:Time Factors
D008077:Lipoproteins, LDL; D002784:Cholesterol
LDL-aféresis con método de doble filtración. Resultados obtenidos en el seguimiento a 6 y 12 meses en 5 pacientes con hiperlipemia refracteria y cardiopatía isquémica.