[Immunologic function of the placenta and endothelium in virus infection; non-specific immunity].
A placenta constitutes a specific immune system that can protect a fetus against viral infections. We examined TNF, IFN and IL-6 production in organ cultures of human placenta and amniotic membrane. VSV replication and the cytokine production (TNF, IFN, IL-6) by human umbilical cord vein organ cultures and isolated endothelial cells were compared. We suggest that the local production of cytokines is responsible for the antiviral activity of placenta and endothelium.
Paradowska
E
E
Laboratorium Wirusologii, Zakład Immunologii Chorób Zakaźnych.
D000650:Amnion / Q000276:immunology; D004727:Endothelium / Q000276:immunology*; D005333:Fetus / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D009924:Organ Culture Techniques; D010920:Placenta / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014777:Virus Diseases / Q000276:immunology*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons
Immunologiczne funkcje łozyska i śróbłonka w zakazeniach wirusowych; nieswoiste mechanizmy obronne.