Effects of endotoxin on lipid metabolism.
Endotoxin, via cytokines, induces marked changes in lipid metabolism which are now considered part of the acute phase response. The endotoxin induced hyperlipidemia may represent a nonspecific immune response that can decrease the toxicity of a variety of harmful biological and chemical agents and serve to redistribute nutrients to cells important in host defense. The endotoxin induced changes in lipid metabolism may therefore be beneficial.
Hardardóttir
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I
Department of Medicine, University of California San Francisco, USA.
Grunfeld
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C
Feingold
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KR
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004731:Endotoxins / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D007239:Infections / Q000378:metabolism; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D010272:Parasitic Diseases / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D014777:Virus Diseases / Q000378:metabolism
D004731:Endotoxins; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol