Effects of lodoxamide (LOD), disodium cromoglycate (DSCG) and N-acetyl-aspartyl-glutamate sodium salt (NAAGA) on ocular active anaphylaxis.
LOD, DSCG and NAAGA eye-drops were evaluated on experimentally-induced ocular active anaphylaxis in guinea pigs. Twelve animals per group were sensitized with egg albumin i.p. and challenged on the surface of the eye 14 days later. Two days before challenge, animals were treated with LOD, DSCG or NAAGA 4 times a day. Permeability indexes were calculated after intracardiac injection of Evans Blue. No effect on ocular active anaphylaxis was found with LOD nor with DSCG. NAAGA was able to significantly reduce blood-eye permeability indexes.
Goldschmidt
P
P
C.H.U. Pitié-Salpétrière, Paris, France.
Luyckx
J
J
D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D003231:Conjunctivitis / Q000276:immunology; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004151:Dipeptides / Q000627:therapeutic use*; D005123:Eye / Q000276:immunology; D006168:Guinea Pigs; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004151:Dipeptides; D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; C027172:isospaglumic acid; D004205:Cromolyn Sodium; D010072:Oxamic Acid; C021702:lodoxamide ethyl