title: Topical treatment of erectile dysfunction: randomised double blind placebo controlled trial of cream containing aminophylline, isosorbide dinitrate, and co-dergocrine mesylate.
abstract: OBJECTIVE
  To examine the effectiveness in treating impotence to topically applied cream containing three vasodilators--aminophylline, isosorbide dinitrate, and co-dergocrine mesylate--which act by different mechanisms.
  
  
  METHODS
  Randomised double blinded placebo controlled crossover trial over two weeks.
  
  
  METHODS
  36 men with erectile dysfunction randomly allocated to two equal groups.
  
  
  METHODS
  Active cream containing aminophylline 3%, isosorbide dinitrate 0.25%, and co-dergocrine mesylate 0.05% for one week and placebo for another.
  
  
  METHODS
  Patients' reported experience of penile responses and side effects of treatment in questionnaires. Penile tumescence and arterial flow in the laboratory.
  
  
  RESULTS
  21 patients reported full erection and satisfactory intercourse with the active cream. Three men reported full erection and satisfactory intercourse with either cream. The active cream was more effective in psychogenic than organic impotence (eight out of nine men with psychogenic impotence achieved a full erection upsilon four out of eight with neurogenic impotence and two out of seven with arterial insufficiency). No major side effects were reported. In the laboratory the active cream increased penile arterial flow (0.19 (SD 0.08) m/s upsilon 0.02 (0.15) m/s with placebo) and induced tumescence in 24 patients.
  
  
  CONCLUSIONS
  Topical treatment with a cream containing three different vasodilators might be considered before intracavernous injection of vasoactive agents, particularly in psychogenic impotence.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Gomaa
authors.forename: M
authors.initials: M
authors.lastname: Shalaby
authors.forename: M
authors.initials: M
authors.lastname: Osman
authors.forename: M
authors.initials: M
authors.lastname: Eissa
authors.forename: A
authors.initials: A
authors.lastname: Eizat
authors.forename: M
authors.initials: M
authors.lastname: Mahmoud
authors.forename: N
authors.initials: N
authors.lastname: Mikhail
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage*; D001783:Blood Flow Velocity; D004311:Double-Blind Method; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000188:drug therapy*; D004877:Ergoloid Mesylates / Q000008:administration & dosage*; D006801:Humans; D018783:Impotence, Vasculogenic / Q000188:drug therapy; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D017060:Patient Satisfaction; D010413:Penis / Q000098:blood supply; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D009824:Ointments; D014665:Vasodilator Agents; D000628:Aminophylline; D004877:Ergoloid Mesylates; D007548:Isosorbide Dinitrate