Beta-nerve growth factor as a mediator of the acute phase response in vivo.
Nerve growth factor (NGF) is increased during inflammation and stress. Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of the acute phase response which is mediated by cytokines. We now report the effect of systemic administration of beta-NGF on levels of serum lipids and SAA. Beta-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, beta-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, beta-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.
Nonogaki
K
K
Department of Medicine, University of California, San Francisco, 94121 USA.
Moser
A H
AH
Shigenaga
J
J
Feingold
K R
KR
Grunfeld
C
C
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007249:Inflammation; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D000685:Serum Amyloid A Protein / Q000096:biosynthesis* / Q000187:drug effects; D013312:Stress, Physiological; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D009414:Nerve Growth Factors; D011994:Recombinant Proteins; D000685:Serum Amyloid A Protein; D014280:Triglycerides; D002784:Cholesterol