title: Localization of the human RGR opsin gene to chromosome 10q23.
abstract: The human RGR gene encodes an opsin protein (retinal G protein-coupled receptor), which is expressed in Müller cells and the retinal pigment epithelium and is thought to play a role in the visual process. To investigate a possible linkage of the RGR gene to retinal dystrophies, the locus of the gene was mapped on human metaphase chromosomes. Genomic and cDNA fragments of the human RGR gene were used as probes for fluorescence in situ hybridization. Analysis of the fluorescence signals on high-resolution banded chromosomes showed that the RGR gene is localized to human chromosome 10q23. This result now provides for the rapid analysis of this gene with respect to inherited diseases of the retina.
authors.affiliation: Ahmanson Department of Pediatrics, Cedars-Sinai Research Institute/UCLA 90048, CA, USA.
authors.forename: X N
authors.initials: XN
authors.lastname: Chen
authors.forename: J R
authors.initials: JR
authors.lastname: Korenberg
authors.forename: M
authors.initials: M
authors.lastname: Jiang
authors.forename: D
authors.initials: D
authors.lastname: Shen
authors.forename: H K
authors.initials: HK
authors.lastname: Fong
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping / Q000379:methods; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D015342:DNA Probes; D005136:Eye Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D011956:Receptors, Cell Surface / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D017299:Rod Opsins / Q000235:genetics*
chemical_list: D015342:DNA Probes; D005136:Eye Proteins; C089754:G protein-coupled receptor RGR; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D017299:Rod Opsins