title: Pseudoepitheliomatous, keratotic and micaceous balanitis. Case report and review of the literature.
abstract: A case of pseudoepitheliomatous, keratotic and micaceous balanitis (PEKMB) in a 64-year old man is presented. The patient presented with the 2-year history of a slowly enlarging, hyperkeratotic plaque on his glans penis that was compatible with a clinical diagnosis of PEKMB. The lesion has been treated successfully with tropical 5-fluorouracil cream, with no evidence of recurrence at 2-year follow-up. Histological examination revealed acanthosis, hyperkeratosis, and pseudoepitheliomatous hyperplasia with no cytological atypia. This rare penile condition was considered pseudomalignant, premalignant, or as a low-grade squamous malignancy. Apart from this patient we comprehensively review previously reported cases, and discuss a possible concept on etiology, diagnosis and treatment of this entity.
authors.affiliation: Institute for Dermatology and Venereolgy, University Clinical Center, Medical School, Belgrade, Yugoslavia.
authors.forename: A L
authors.initials: AL
authors.lastname: Krunic
authors.forename: K
authors.initials: K
authors.lastname: Djerdj
authors.forename: A
authors.initials: A
authors.lastname: Starcevic-Bozovic
authors.forename: M M
authors.initials: MM
authors.lastname: Kozomara
authors.forename: N M
authors.initials: NM
authors.lastname: Martinovic
authors.forename: S A
authors.initials: SA
authors.lastname: Vesic
authors.forename: J H
authors.initials: JH
authors.lastname: Djokic
mesh_terms: D001446:Balanitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D005472:Fluorouracil