Alport's syndrome in monozygotic twins.
Identical twins presented at the same time with renal failure. They also recalled a simultaneous history of "nephritis" as early as the age of 6 years. Renal biopsies revealed variably thickened glomerular basement membranes with the lamellation and splitting characteristic of Alport's syndrome. Bilateral sensorineural deafness was demonstrated in both twins on audiometric testing. A positive family history in the mother and one elder sister confirmed the diagnosis of Alport's syndrome. This is the first reported case of Alport's syndrome occurring in monozygotic twins.
Wang
A Y
AY
Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, New Territories, Hong Kong.
Lai
K N
KN
Lai
F M
FM
Leung
C B
CB
Li
P K
PK
D000328:Adult; D001485:Basement Membrane / Q000473:pathology; D004200:Diseases in Twins; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D051437:Renal Insufficiency / Q000235:genetics / Q000601:surgery; D014430:Twins, Monozygotic