title: [Experiences with the NoToX formalin substitute solution].
abstract: "NoToX Histological Fixative" is a formaldehyde substitute for the fixation of tissues prior to histological investigation. Intraoperative samples and necropsy tissue were tested. NoToX was substituted for formaldehyde in the fixation step, otherwise the same manufacturer-specified protocols were used for all reagents. Conventional histological and accepted immunohistological investigations, especially for tumour diagnosis, were used. In all tests, results with NoToX-fixated tissue were similar to those with tissue fixed with formaldehyde regarding both staining and diagnosis. NoToX is a useful substitute for formaldehyde.
authors.affiliation: Institut für Pathologie, Rudolf-Virchow-Haus, Universitätsklinikum Charité der Humboldt-Universität zu Berlin.
authors.forename: R
authors.initials: R
authors.lastname: Meyer
authors.forename: F
authors.initials: F
authors.lastname: Niedobitek
authors.forename: K
authors.initials: K
authors.lastname: Wenzelides
mesh_terms: D001344:Autopsy; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005404:Fixatives; D005557:Formaldehyde; D006652:Histological Techniques; D006801:Humans; D007124:Immunoenzyme Techniques; D009369:Neoplasms / Q000473:pathology; D016707:Tissue Fixation
chemical_list: D014408:Biomarkers, Tumor; D005404:Fixatives; D005557:Formaldehyde
vernacular_title: Erfahrungen mit der Formalinersatzlösung NoToX.