Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.
We isolated a partial genomic clone encoding ITGAD, a novel beta 2-integrin alpha subunit. The ITGAD gene is highly homologous to the three previously known alpha subunit-encoding genes, that compose the beta 2 integrin family, in deduced amino acid sequence, intron/exon structure and mapping location (chromosome 16p11).
Wong
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Center For Blood Research, Harvard Medical School, Boston, MA 02115, USA.
Davis
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LeBeau
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Springer
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D000595:Amino Acid Sequence; D001483:Base Sequence; D018845:CD11 Antigens; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D003001:Cloning, Molecular; D006801:Humans; D039001:Integrin alpha Chains; D016023:Integrins / Q000235:genetics*; D008969:Molecular Sequence Data; D016024:Receptors, Cytoadhesin; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
D018845:CD11 Antigens; C406812:ITGAD protein, human; D039001:Integrin alpha Chains; D016023:Integrins; D016024:Receptors, Cytoadhesin