Increased leukocyte adhesiveness/aggregation in patients with inflammatory bowel disease during remission. Further evidence for subclinical inflammation.
OBJECTIVE
We have used a novel leukocyte adhesiveness/aggregation test (LAAT) to show that many patients with inflammatory bowel disease (IBD) in clinical remission have a subclinical low grade inflammation.


METHODS
Included in the study are 500 controls, 96 patients with IBD in remission, and 106 patients in relapse.


RESULTS
The percent of aggregated white blood cells detected in the peripheral blood was 5.9 +/- 3.9, 9.1 +/- 5.9, and 18.8 +/- 9.4, respectively. The difference between each group and any other was significant at P < 0.0001. Similar results were obtained when other acute phase reactants like the erythrocyte sedimentation rate, white blood cell count, differential count, and C-reactive protein level were examined. However, in a linear regression analysis, LAAT was the only significant (P < 0.0006) variable that could classify correctly each subject to the appropriate category of control and IBD in remission or relapse.


CONCLUSIONS
Identification of patients with IBD in clinical remission who have ongoing inflammation may be of clinical-therapeutic relevance. The LAAT is a simple, rapid, and convenient test. The present study indicates that it is also very sensitive.
Arber
N
N
Department of Gastroenterology, Tel-Aviv Medical Center Ichilov Hospital, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Hallak
A
A
Dotan
I
I
Bujanover
Y
Y
Liberman
E
E
Santo
M
M
Moshkowitz
M
M
Tiomny
E
E
Aronson
M
M
Berliner
S
S
Gilat
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000737:chemistry; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000276:immunology*; D007957:Leukocyte Adherence Inhibition Test / Q000379:methods*; D007958:Leukocyte Count; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D015415:Biomarkers; D002097:C-Reactive Protein