Angiotensin I-converting enzyme (ACE) polymorphism and ABO blood groups as factors codetermining plasma ACE activity.
The activity of serum angiotensin I-converting enzyme (ACE) was measured in 197 unrelated healthy Caucasian subjects. Plasma ACE activity was correlated with sex, ABO blood groups, and ACE insertion/deletion (I/D) polymorphism. Marked differences in plasma ACE activity levels were observed both among the blood groups and among ACE phenotypes. The corresponding ACE activities were as follows: blood group A, 19.45+/-0.96 (mean+/-SE); O, 20.74+/-1.58; B, 26.17+/-1.40; AB, 24.77+/-1.93 (U/mL: F=4.173; p=0.006983). With ACE genotypes: II, 16.96+/-1.33; ID, 24.25+/-1.05; DD, 27.14+/-1.20 (U/mL; F=6.359; p=0.002165). No difference was observed between men and women. The I/D polymorphism and the ABO system turned out to be two independent (additive) factors influencing plasma ACE activity. Together, they are responsible for 9.56% of the phenotypic variability of ACE. We discuss the role of the ABO system in the known effects of glycosylation of proteins.
Cídl
K
K
Institute of Pathological Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic.
Strelcová
L
L
Znojil
V
V
Váchi
J
J
D000017:ABO Blood-Group System / Q000032:analysis*; D000328:Adult; D018153:Czech Republic; D005260:Female; D005787:Gene Frequency; D006031:Glycosylation; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D011499:Protein Processing, Post-Translational
D000017:ABO Blood-Group System; D007703:Peptidyl-Dipeptidase A