title: Spin-echo and 3D gradient-echo imaging of the knee joint: a clinical and histopathological comparison.
abstract: OBJECTIVE
  A clinical and histopathological comparison of 2D spin-echo (SE) and 3D gradient-echo (3DGE) sequences was undertaken for the knee joint. The purpose of the study was to evaluate the clinical results and to explain the different appearances of meniscal abnormalities on both 2DSE and 3DGE images.
  
  
  METHODS
  The clinical study comprised 45 patients with arthroscopically correlated MR imaging results. For the histopathological correlation, seven cadaveric knee joints were examined with the same 2DSE and 3DGE (FISP) imaging protocol and sliced in sagittal sections according to the MR images. Different stainings were used.
  
  
  RESULTS
  For the detection of meniscal tears, accuracy (82.2%) and positive predictive value (70.7%) of the 3DGE sequence were limited due to a high number of false positive findings. Cartilaginous lesions were more easily visible on 3DGE than on 2DSE images (sensitivity: 63.1% vs. 52.6%, respectively). As in the clinical study, the meniscal signal abnormalities of the cadaveric knee joints were much more extensive on the 3DGE images than on the 2DSE images. The 3DGE findings correlated better with degenerative meniscal changes which were visible microscopically.
  
  
  CONCLUSIONS
  The high sensitivity of the 3DGE sequence for degenerative meniscal changes explains the lack of specificity for the differentiation between meniscal degeneration and tears with this sequence. The MR grading system for meniscal lesions is of limited value for the evaluation of 3D FISP images.
authors.affiliation: Department of Radiology, University Hospital of Basle, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Gückel
authors.forename: G
authors.initials: G
authors.lastname: Jundt
authors.forename: K
authors.initials: K
authors.lastname: Schnabel
authors.forename: A
authors.initials: A
authors.lastname: Gächter
mesh_terms: D000328:Adult; D000368:Aged; D016118:Anterior Cruciate Ligament / Q000473:pathology; D000070598:Anterior Cruciate Ligament Injuries; D001182:Arthroscopy; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007718:Knee Injuries / Q000175:diagnosis* / Q000473:pathology; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology; D008875:Middle Aged; D016119:Posterior Cruciate Ligament / Q000293:injuries / Q000473:pathology; D012680:Sensitivity and Specificity; D000070600:Tibial Meniscus Injuries