[Importance of genetic factors in pathogenesis of subacute spongiform viral encephalitis].
Recently there has been achieved a substantial progress in research concerning pathogenesis of subacute spongiform viral encephalopathies. For this group of disorders, there has been found a common unconventional virus - proteinaceous infectious particle (PrP). There has been recognised a molecular mass, biochemical composition and physicochemical properties of this infectious form. Mutations of scrapie amyloid precursor gene discovered in Gerstmann-Sträussler-Scheinker syndrome (GSS) and familial cases of Creutzfeldt-Jakob disease (CJD) have been revealed. Nowadays examinations in the field of relationships between prion protein and mutations of scrapie precursor gene are continued.
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I Klinika Neurologii Slaskiej Akademii Medycznej w Katowicach.
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D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics; D016098:Gerstmann-Straussler-Scheinker Disease / Q000235:genetics; D006801:Humans; D009154:Mutation; D018621:PrPC Proteins / Q000235:genetics; D017096:Prion Diseases / Q000235:genetics*
D018621:PrPC Proteins
Znaczenie czynników genetycznych w patogenezie podostrych transmisyjnych encefalopatii gabczastych.