Dexamethasone decreases the expression of retinoic acid receptors (RARs) in rat liver.
Although adrenalectomy was without effect on the expression of retinoic acid (RA) receptors (RARs), administration of the glucocorticoid analog dexamethasone (Dex) to both control and adrenalectomized rats reduced the expression of these receptors in rat liver. This effect can be mainly attributed to the action of Dex on 4-hydroxylation of RA. Dex, by enhancing 4-hydroxylation of RA, reduces its intracellular concentration thereby leading to a decreased expression of RARs, since RARbeta, the main type of RARs in liver, are known to be up-regulated by RA.
Pallet
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Laboratoire de Nutrition, Université Bordeaux I, Talence, France.
Audouin-Chevallier
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I
Higueret
D
D
Garcin
H
H
Higueret
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P
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001483:Base Sequence; D003907:Dexamethasone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D018168:Receptors, Retinoic Acid / Q000096:biosynthesis* / Q000235:genetics; D014212:Tretinoin / Q000494:pharmacology
D005938:Glucocorticoids; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D003907:Dexamethasone