Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El.
El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El mice in a dose-dependent manner. Furthermore, thrombin-treated mice manifested no convulsions, but thrombin receptor activating peptide-treated ones had convulsions. These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions.
Masuda
Y
Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Miura
N
N
Kawarada
Y
Y
Kawagoe
M
M
Shimizu
T
T
Sugiyama
T
T
Hishikawa
Y
Y
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000077214:Becaplermin; D004195:Disease Models, Animal; D004830:Epilepsy, Tonic-Clonic / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D009842:Oligopeptides / Q000494:pharmacology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D020574:Proto-Oncogene Proteins c-sis; D018179:Receptors, Thrombin; D011994:Recombinant Proteins / Q000494:pharmacology; D012640:Seizures / Q000235:genetics / Q000517:prevention & control*; D013917:Thrombin / Q000494:pharmacology; D013997:Time Factors
D000927:Anticonvulsants; D009842:Oligopeptides; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D018179:Receptors, Thrombin; D011994:Recombinant Proteins; C075278:platelet-derived growth factor A; C096900:thrombin receptor-activating peptide SFLLRNPNDKY; D000077214:Becaplermin; D013917:Thrombin