Antimutagenicity of yogurt.
Yogurt is milk fermented by a mixture of two bacteria: Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus salivarius ssp. thermophilus. Epidemiological studies have correlated a reduced risk of colon cancer with yogurt consumption. Independent studies have established that yogurt and extracts thereof are antimutagenic. Although multiple explanations can account for yogurt's putative anticarcinogenicity, we are interested in testing the hypothesis that antimutagenic compounds produced during fermentation are responsible. We recently reported on the antimutagenicity of an acetone extract of yogurt against the experimental carcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 3.2'dimethyl-4-aminobiphenyl (DMAB) (Mutation Res. (1995) 334, 213-224). We are now aware that palmitic acid is an active ingredient against MNNG.
Bakalinsky
A T
AT
Department of Food Science and Technology, Oregon State University, Corvallis 97331, USA.
Nadathur
S R
SR
Carney
J R
JR
Gould
S J
SJ
D000611:Aminobiphenyl Compounds / Q000633:toxicity; D016587:Antimutagenic Agents / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D005285:Fermentation; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000235:genetics; D015014:Yogurt / Q000032:analysis
D000611:Aminobiphenyl Compounds; D016587:Antimutagenic Agents; D005227:Fatty Acids; D009153:Mutagens; D010169:Palmitic Acids; D008769:Methylnitronitrosoguanidine; C001042:2',3-dimethyl-4-aminobiphenyl; D019308:Palmitic Acid