title: Cervical biopsy-cytology correlation. A College of American Pathologists Q-Probes study of 22 439 correlations in 348 laboratories.
abstract: OBJECTIVE
  To study the diagnostic correlation between cervical cytology specimens and corresponding surgical biopsies.
  
  
  METHODS
  College of American Pathologists Q-Probes laboratory quality improvement study in 348 laboratories.
  
  
  METHODS
  Sensitivity, specificity, and positive predictive value of cervicovaginal cytology diagnosis.
  
  
  RESULTS
  Statistical analysis of 22 439 paired cervicovaginal cytology--cervical biopsy specimens reveals a sensitivity of 89.4%, specificity of 64.8%, and predictive value of a positive cytology of 88.9%. The majority of discrepancies were attributed to cytology or biopsy sampling errors. Routinely providing the patient's recent cervical cytology report to the surgical pathologist at the time the biopsy was examined resulted in improved sensitivity. Correlations for cytology specimens obtained at the time of biopsy revealed lower sensitivity and higher specificity than for those obtained at a time prior to the biopsy.
  
  
  CONCLUSIONS
  We have defined current statistical expectations for cervical cytology-biopsy correlation, reasons for noncorrelation, and have provided recommendations for quality improvement.
authors.affiliation: Department of Pathology, St John Hospital and Medical Center, Detroit, MI 48236, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Jones
authors.forename: D A
authors.initials: DA
authors.lastname: Novis
mesh_terms: D001706:Biopsy / Q000592:standards*; D002584:Cervix Uteri / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007753:Laboratories / Q000592:standards*; D018307:Neoplasms, Squamous Cell / Q000473:pathology*; D010340:Pathology, Surgical / Q000592:standards*; D011237:Predictive Value of Tests; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012955:Societies, Medical; D014481:United States; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000592:standards*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*