title: Prefrontal cortical mediation of rats' place learning in a modified water maze.
abstract: The acquisition of a place learning task in a water maze modified from the "standard" set-up by restriction of distal cues and addition of "proximal" cues (ping-pong balls in fixed positions on the surface of the water) was tested in three groups of rats: (I) animals subjected to bilateral ablation of the anteromedial prefrontal cortex, (II) rats in which the parietal "association" cortex had been removed bilaterally, and (III) a sham operated control group. The task acquisition of the prefrontally ablated group was significantly impaired, whereas the animals in which the parietal cortex had been removed acquired the task as quickly as the control group. Upon reaching criterion level performance all animals were tested on "challenge" sessions on which the cues were manipulated. Such "challenges" demonstrated that the animals of all three groups discriminated between the distal cues and utilized such a discrimination for navigational purposes.
authors.affiliation: Department of Pharmacology, University of Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Mogensen
authors.forename: T K
authors.initials: TK
authors.lastname: Pedersen
authors.forename: S
authors.initials: S
authors.lastname: Holm
authors.forename: L E
authors.initials: LE
authors.lastname: Bang
mesh_terms: D000818:Animals; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming