title: Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: the Linxian Nutrition Intervention Trial.
abstract: A total of 3,318 men and women from a region in rural China were randomized to receive daily either a multiple vitamin/mineral supplement or a placebo. Deaths that occurred in the participants were ascertained and classified according to cause over the 6-year period from 1985 to 1991. At the end of supplementation, blood pressure readings were taken, and the prevalence of hypertension was determined. There was a slight reduction in overall mortality in the supplement group (relative risk (RR) = 0.93, 95 percent confidence interval (CI) 0.75-1.16), with the decreased relative risk most pronounced for cerebrovascular disease deaths (RR = 0.63, 95 percent CI 0.37-1.07). This benefit was greater for men (RR = 0.42, 95 percent CI 0.19-0.93) than for women (RR = 0.93, 95 percent CI 0.44-1.98). Among the survivors, the presence of elevations in both systolic and diastolic blood pressures was less common in those who received the supplement (RR for men = 0.43, 95% CI 0.28-0.65; RR for women = 0.92, 95 percent CI 0.68-1.24). This study indicates that supplementation with a multivitamin/mineral combination may have reduced mortality from cerebrovascular disease and the prevalence of hypertension in this rural population with a micronutrient-poor diet.
authors.affiliation: National Cancer Institue, Bethesda, MD, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Mark
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: J F
authors.initials: JF
authors.lastname: Fraumeni
authors.forename: J Y
authors.initials: JY
authors.lastname: Li
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
authors.forename: G Q
authors.initials: GQ
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Guo
authors.forename: S M
authors.initials: SM
authors.lastname: Dawsey
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: W J
authors.initials: WJ
authors.lastname: Blot
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000517:prevention & control*; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000517:prevention & control*; D015994:Incidence; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data; D014131:Trace Elements / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014131:Trace Elements; D014815:Vitamins