Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea.
Hybrid ribosomes obtained by mixing the ribosomal subunits of the extremely thermophilic archaea Sulfolobus solfataricus and Desulfurococcus mobilis were tested for their sensitivity to selected antibiotics. It is shown that structural differences in the large ribosomal subunits determine qualitatively and quantitatively the patterns of response to alpha-sarcin and paromomycin in these species.
Ruggero
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D
Dpt. Biopatologia Umana, Sez. Biologia Cellulare, Università di Roma "La Sapienza," Italy.
Londei
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P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001105:Archaea / Q000187:drug effects*; D004722:Endoribonucleases; D005656:Fungal Proteins / Q000494:pharmacology*; D010303:Paromomycin / Q000494:pharmacology*; D012270:Ribosomes / Q000187:drug effects*; D016944:Sulfolobus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005656:Fungal Proteins; C014801:alpha-sarcin; D010303:Paromomycin; D004722:Endoribonucleases