Inhibitory effect of caloric restriction on tumorigenicity induced by 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in the CD1 newborn mouse bioassay.
The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the caloric restricted mice developed tumors. These results indicate that caloric restriction, even when begun 3 months after the conclusion of compound treatment, markedly inhibited 4-ABP- and PhIP-induced tumors in the CD1 mouse.
Von Tungeln
L S
LS
Department of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Bucci
T J
TJ
Hart
R W
RW
Kadlubar
F F
FF
Fu
P P
PP
D000611:Aminobiphenyl Compounds / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens / Q000633:toxicity*; D004038:Diet, Reducing; D002149:Energy Intake; D007093:Imidazoles / Q000633:toxicity*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D007093:Imidazoles; C006757:4-biphenylamine; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine