title: [Interdisciplinary surgical therapy of renal tumors with intracardiac tumor thrombi].
abstract: A combination of increased perioperative morbidity, together with the technical difficulty of an R 0 (curative) resection, is responsible for the poor prognostic factors of supradiaphragmatically extending renal tumors. Six patients aged 53-70 years with vena cava thrombosis extending into the right atrium or ventricle underwent en bloc resection of the primary tumor and tumor thrombus removal. If the atrial tumor mass was large or extended into the ventricle, resection was performed during cardiopulmonary arrest using a cardiopulmonary bypass method with the patient in deep hypothermia (< 18 degrees C). Alternatively if the cardiac tumor infiltration was minimal, resection was performed during an optionally short cardiopulmonary arrest period using a cardiopulmonary bypass method with the patient in hypothermia (23 degrees C). The operative procedure was determined by intracardiac tumor extension, tumor wall adhesions and tumor wall infiltrations, all of which were assessed intraoperatively by vena cava sonography. Six patients were strongly symptomatic preoperatively. Three developed sudden life-threatening cardiopulmonary insufficiency, possibly due to longer-lasting tricuspital valve prolapse with a consecutive right-to-left shunt through a newly reopened foramen ovale. One patient died 14 months postoperatively because of multiple metastases (hepatic, pulmonary and bone). One patient is still alive and has had a local recurrence for 2 months, which was diagnosed 65 months postoperatively. The remaining four patients are alive and well. They have been tumor-free for extended periods of time (29, 34, 62 and 84 months, respectively).
authors.affiliation: Urologische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.
authors.forename: Z
authors.initials: Z
authors.lastname: Akçetin
authors.forename: W
authors.initials: W
authors.lastname: Schafhauser
authors.forename: R
authors.initials: R
authors.lastname: Kühn
authors.forename: J
authors.initials: J
authors.lastname: Scheele
authors.forename: J
authors.initials: J
authors.lastname: Weniger
authors.forename: K M
authors.initials: KM
authors.lastname: Schrott
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006324:Heart Arrest, Induced; D006325:Heart Atria / Q000473:pathology / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D010348:Patient Care Team; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D015996:Survival Rate; D014684:Venae Cavae / Q000473:pathology / Q000601:surgery
vernacular_title: Interdisziplinäre operative Therapie der renalen Tumoren mit intrakardialen Tumorthromben.