The effect of oral cisapride premedication on fasting gastric volumes.
The aim of this study was to determine whether fasting gastric volumes could be reduced by preoperative administration of cisapride. One hundred and twenty-one patients undergoing elective general anaesthesia were randomly allocated to receive either cisapride 20 mg plus diazepam 10 mg or placebo tablets plus diazepam 10 mg, two hours prior to induction. Immediately following induction blind gastric aspiration was performed using a 16Fr multiorificed orogastric tube. Gastric volume, pH, and cisapride blood concentration were measured at this time. Gastric volumes were significantly smaller in the cisapride group, 20.5 (SD 22.2) ml compared to placebo 28.2 (SD 26.0) ml but there was no significant difference with respect to pH. Some patients in both groups had large gastric volumes despite fasting. No significant adverse effects were noted with cisapride.
Kluger
M T
MT
Flinders Medical Centre, Adelaide, South Australia.
Owen
H
H
Plummer
J L
JL
McLean
C
C
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D020117:Cisapride; D003975:Diazepam / Q000008:administration & dosage; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D005215:Fasting; D005746:Gastric Emptying / Q000187:drug effects; D005766:Gastrointestinal Contents / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007441:Intubation, Gastrointestinal / Q000295:instrumentation; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010919:Placebos; D011292:Premedication; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013396:Suction
D000759:Adjuvants, Anesthesia; D006993:Hypnotics and Sedatives; D010880:Piperidines; D010919:Placebos; D012702:Serotonin Antagonists; D003975:Diazepam; D020117:Cisapride