title: Lesions of primary and secondary syphilis contain activated cytolytic T cells.
abstract: This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated.
authors.affiliation: Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: van Voorhis
authors.forename: L K
authors.initials: LK
authors.lastname: Barrett
authors.forename: J M
authors.initials: JM
authors.lastname: Nasio
authors.forename: F A
authors.initials: FA
authors.lastname: Plummer
authors.forename: S A
authors.initials: SA
authors.lastname: Lukehart
mesh_terms: D001483:Base Sequence; D053804:Granzymes; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D012697:Serine Endopeptidases / Q000235:genetics; D013587:Syphilis / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014210:Treponema pallidum / Q000276:immunology
chemical_list: D012333:RNA, Messenger; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases