The effect of modification of acrylic resins on controlled release and bioadhesion.
The effect of various treatments on the properties of an acrylic matrix was studied, in terms of its swelling properties in buffer solution. The release of two types of drugs from those matrices and their bioadhesive character were also considered. Calcium stearate and sodium lauryl sulfate were used as additives for the matrix treatment. 2-Hydroxyethyl methacrylate was also used as a reactive agent for the acrylic resin treatment. The main function of the above chemicals is the modification of the hydrophilic/hydrophobic character of the matrix. This investigation showed that controlled release systems can be designed by adjusting the matrix properties via additives or chemical reaction.
Vlachou
M
M
Department of Pharmacy, University of Athens, Greece.
Choulis
N H
NH
Efentakis
M
M
Andreopoulos
A G
AG
D000180:Acrylic Resins / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D000180:Acrylic Resins; D001672:Biocompatible Materials; D011108:Polymers