title: Tamoxifen-induced growth of leiomyomas. A case report.
abstract: BACKGROUND
  Tamoxifen, a nonsteroidal estrogen agonist-antagonist, is used in the treatment of breast cancer.
  
  
  METHODS
  A postmenopausal woman, aged 73, while being treated with Tamoxifen, developed continuous growth of her myomatous uterus, became symptomatic and required surgery.
  
  
  CONCLUSIONS
  Tamoxifen at a dose of 40 mg/d has been associated with endometrial carcinoma. The growth of myomas seen with Tamoxifen in this patient seems to be a result of its direct agonist properties.
authors.affiliation: Department of Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kang
authors.forename: L
authors.initials: L
authors.lastname: Baxi
authors.forename: D
authors.initials: D
authors.lastname: Heller
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000628:therapy; D002278:Carcinoma in Situ / Q000628:therapy; D018275:Carcinoma, Lobular / Q000628:therapy; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000139:chemically induced* / Q000601:surgery; D017698:Postmenopause; D013629:Tamoxifen / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000601:surgery
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen