Efficacy and tolerability of antidepressant therapy in the old-old.
As the number of elderly increases worldwide, there will be a concurrent increase in the absolute number of people over 70 years of age who suffer from major depressive disorders. There is a paucity of research in this old-old population, although each of the following drugs has been studied in at least one clinical drug trial: amitriptyline, bupropion, dothiepin, fluoxetine, mianserin, nortriptyline, paroxetine, and sertraline. The results to date, though limited, suggest similar efficacy and greater tolerability of serotonin selective reuptake inhibitors compared with tricyclic antidepressants in the elderly.
Finkel
S I
SI
Department of Psychiatry and Behavioral Sciences, Northwestern University Medical School, Chicago, Ill 60611, USA.
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors