Human G(alpha q): cDNA and tissue distribution.
G(alpha q), a member of the Gq family of heterotrimeric G proteins, transduces signals from several G protein-coupled receptors that stimulate membrane phosphoinositide hydrolysis. In order to further define the role of G(alpha q) in the function of G protein-coupled receptors, we have cloned the cDNA encoding human G(alpha q) from a prostate cDNA library. Human G(alpha q) exhibits high homology with its mouse homolog - 94% similarity at the nucleotide level, and 99% similarity at the amino acid level. Northern hybridization data indicate high expression of G(alpha q) mRNA in organs of the human reproductive system including ovary, prostate, and testis.
Chen
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B
Department of Anesthesiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Leverette
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RD
Schwinn
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DA
Kwatra
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MM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D018076:DNA, Complementary / Q000737:chemistry*; D005260:Female; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D010053:Ovary / Q000737:chemistry; D011467:Prostate / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis; D017385:Sequence Homology; D013737:Testis / Q000737:chemistry; D014018:Tissue Distribution
D018076:DNA, Complementary; D046911:Macromolecular Substances; D012333:RNA, Messenger; D019204:GTP-Binding Proteins