Immunotherapy with a standardized Dermatophagoides pteronyssinus glutaraldehyde-modified extract against an unmodified extract: a comparative study of efficacy, tolerance and in vivo and in vitro modification of parameters.
We comparatively studied clinical efficacy, tolerance and modifications of different in vivo and in vitro parameters induced by two biologically standardized Dermatophagoides pteronyssinus extracts (HEP units), one glutaraldehyde-modified, in patients with allergic rhinitis and/or bronchial asthma after a year of treatment. A decrease in drug consumption was observed in both treatment groups (p < 0.0001). Of all the in vivo parameters studied (cutaneous, conjunctival and bronchial reactivity to the allergen), a decrease in specific bronchial reactivity was only observed in the group treated with the modified extract (p < 0.05). The modifications in total IgE, specific IgE and specific total IgG levels are superimposable on those described in previous papers on immunotherapy. However, IgG4 levels remained stable with respect to time. Tolerance was good and very similar for both treatments; both types of extracts are equally efficacious and safe.
Echechipía
S
S
Allergy Service, Santiago Apóstol Hospital, Vitoria, Spain.
Tabar
A I
AI
Lobera
T
T
Muñoz
D
D
Rodríguez
A
A
Blasco
A
A
Olaguíbel
J M
JM
Casanovas
M
M
Fernández de Corres
L
L
D000293:Adolescent; D000328:Adult; D000818:Animals; D001249:Asthma / Q000276:immunology / Q000628:therapy; D001985:Bronchial Provocation Tests; D002648:Child; D003888:Desensitization, Immunologic; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008925:Mites / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000628:therapy; D012882:Skin Tests; D016896:Treatment Outcome
D007074:Immunoglobulin G; D007073:Immunoglobulin E