Effect of octreotide on anal pressure and rectal compliance.
OBJECTIVE
The somatostatin analog, octreotide, has previously been found to influence rectal sensation and may also influence anal resting pressure.


METHODS
We studied the effect of octreotide on anal resting pressure and rectal compliance in eight healthy patients. Octreotide was administered intravenously as a bolus injection in doses of 100 and 10 micrograms or as infusion of 250 micrograms/hour on separate days and compared with placebo.


RESULTS
Within one minute after a bolus injection of 100 micrograms of octreotide, anal resting pressure increased from 56 +/- 12 to 96 +/- 16 cm H2O (P < 0.005). Octrotide had no effect on rectal sensitivity or compliance measurements. Octreotide counteracted rectoanal reflex by increasing anal pressure almost to the level found with an empty rectum.


CONCLUSIONS
Somatostatin thus seems to contribute to the regulation of rectoanal reflex.
Rasmussen
O O
OO
Department of Surgical Gastroenterology D, Herlev Hospital, University of Copenhagen, Denmark.
Hansen
C R
CR
Zhu
B W
BW
Christiansen
J
J
D000328:Adult; D001003:Anal Canal / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D003672:Defecation / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008365:Manometry; D008875:Middle Aged; D015282:Octreotide / Q000494:pharmacology*; D011312:Pressure; D012007:Rectum / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D012018:Reflex / Q000187:drug effects
D005765:Gastrointestinal Agents; D015282:Octreotide