[The cytotoxic activity in intestinal lamina propria and peripheral blood in AIDS and Crohn disease].
In this study the cytotoxic activity of natural killer cells (NK) and lymphokine activated killer cells (LAK) in the peripheral blood was examined in ten patients with AIDS and in ten patients with Crohn's disease. The results were compared to the values of ten healthy patients. Cells of the lamina propria of the colon were isolated and cultivated to LAK-cells after the in vitro stimulation with interleukin-2 from patients belonging to these three groups. The highest NK-activity of the monoclonal cells in the peripheral blood (PBMC) was found in the control group. In patients with AIDS and Crohn's disease the activity of the LAK-cells of PBMC was significantly higher than the activity of the NK-cells. The PBMC activity of NK- and LAK-cells in the control group showed no important differences. The spontaneous cytotoxic activity of mononuclear lamina propria cells was very low or not verifiable. In lamina propria LAK-cells only a very low cytotoxic activity was found too. These results show that an in vitro stimulation of PBMC with interleukin-2 in patients with AIDS or Crohn's disease lead to a significant increase of the cytotoxic cell activity.
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Medizinische Klinik I, Städtisches Krankenhaus Solingen.
Raedler
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Voss
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D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D003106:Colon / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D012016:Reference Values
Zytotoxische Aktivität in der intestinalen Lamina Propria und im Peripheren Blut bei AIDS und M. Crohn.