Induction of human cytotoxic T lymphocytes by oxidized low density lipoproteins.
Oxidized low density lipoproteins (oxLDL) stimulated human blood T cells to a specific cytotoxic response with autologous PHA activated blood mononuclear cells which had been pre-incubated with oxLDL. The cytotoxic reaction was exerted by CD8+ enriched cells but not by CD4+ enriched cells. Allogeneic target cells from HLA mismatched donors were not damaged and the reaction was consistently inhibited by monoclonal antibody against HLA class I. Antigen-specific cytotoxic T cells might contribute to lysis of cells in the atherosclerotic plaque that have taken up oxLDL and thus participate in the inflammatory process associated with atherosclerosis.
Wu
R
R
Immunological Research Laboratory, Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Giscombe
R
R
Holm
G
G
Lefvert
A K
AK
D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D000939:Epitopes / Q000187:drug effects; D006680:HLA Antigens / Q000145:classification / Q000276:immunology; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D010084:Oxidation-Reduction; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein