title: Cocaine-associated intracranial hemorrhage: absence of vasculitis in 14 cases.
abstract: Complications associated with the use of cocaine are varied, and include cerebral hemorrhage and ischemia, with vasculitis and vasospasm as possible etiologies. We reviewed selected brain samples from 14 autopsy cases of cocaine-related cerebrovascular disease. Intracerebral or subarachnoid hemorrhage was present in 12 cases. Intracranial arterioles were either normal or showed nonspecific changes. From these observations, we suggest that intracranial hemorrhages occur in the absence of readily detectable vascular abnormalities.
authors.affiliation: Department of Neurology (K-11), Henry Ford Hospital and Health Science Center, Detroit, MI 48202-2689, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Aggarwal
authors.forename: V
authors.initials: V
authors.lastname: Williams
authors.forename: S R
authors.initials: SR
authors.lastname: Levine
authors.forename: B J
authors.initials: BJ
authors.lastname: Cassin
authors.forename: J H
authors.initials: JH
authors.lastname: Garcia
mesh_terms: D000328:Adult; D001160:Arterioles / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000473:pathology; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications*; D014657:Vasculitis / Q000473:pathology
chemical_list: D003042:Cocaine