title: Inverse relation of serum Helicobacter pylori antibody titres and extent of intestinal metaplasia.
abstract: OBJECTIVE
  To clarify the relation between the serum titre of anti-Helicobacter pylori (H pylori) antibody and the extent of intestinal metaplasia of the gastric mucosa.
  
  
  METHODS
  The serum anti-H pylori IgG titres of 95 asymptomatic individuals (mean age 65 years) undergoing an annual health examination were measured and compared with the extent of intestinal metaplasia (absent, moderate, or extensive), determined by examination of multiple endoscopic mucosal biopsy specimens. Serum pepsinogen I (PGI) levels, as a marker for gastric atrophy, were also measured.
  
  
  RESULTS
  The prevalence of seropositivity for H pylori antibody was high (> 80%), regardless of the extent of metaplasia. However, there was a negative association between the extent of metaplasia and the anti-H pylori titre: 75% of the subjects in the group without metaplasia had high (3+) antibody levels, as did 43% with moderate, and 37% with extensive metaplasia (absent v extensive). The inverse relation between the titre and the extent of metaplasia was evident when examined in those with normal PGI (> 30 ng/ml), whereas no such relation was apparent in subjects with low PGI (< or = 30 ng/ml).
  
  
  CONCLUSIONS
  The anti-H pylori titre correlates inversely with the extent of intestinal metaplasia, particularly in subjects with less marked gastric atrophy.
authors.affiliation: Department of Internal Medicine, Nishiarita Kyoritsu Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Osawa
authors.forename: F
authors.initials: F
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000276:immunology / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008679:Metaplasia / Q000276:immunology / Q000382:microbiology; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D010435:Pepsinogens