An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro.
Rubas
W
W
Genentech, Inc., South San Francisco, California 94080-4990, USA.
Cromwell
M E
ME
Mrsny
R J
RJ
Ingle
G
G
Elias
K A
KA
D000284:Administration, Oral; D001681:Biological Assay; D001692:Biological Transport / Q000502:physiology; D018938:Caco-2 Cells; D002851:Chromatography, High Pressure Liquid; D004848:Epithelium / Q000378:metabolism; D006728:Hormones / Q000493:pharmacokinetics*; D006801:Humans; D016014:Linear Models; D008970:Molecular Weight; D009842:Oligopeptides / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity
D006728:Hormones; D009842:Oligopeptides; C041048:growth hormone releasing hexapeptide