[Xenotransplantation].
This paper describes the rationale behind the need for xenotransplantation and the physiological and immunological barriers associated with xenografting from pig to man. The scientific strategies developed for overcoming the immunological barriers associated with hyperacute rejection are described in detail as is the technology for producing transgenic pigs. Data on perfusion studies of transgenic pig hearts with human blood demonstrates the validity of this scientific approach.
White
D J
DJ
Department of Surgery, University of Cambridge, Grossbritannien.
Calne
R Y
RY
D000818:Animals; D030801:Animals, Genetically Modified; D018958:CD55 Antigens / Q000502:physiology; D003167:Complement Activation / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D008297:Male; D010477:Perfusion; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology*
D018958:CD55 Antigens
Xenotransplantation.