title: Experimental study of combined hyperthermic and photodynamic therapy on carcinoma in the mouse.
abstract: OBJECTIVE
  This study investigates the cytotoxic effect of photodynamic therapy using high-power laser irradiation on cancer cells.
  
  
  METHODS
  High- or low-power irradiation from a pulsed Nd:YAG dye laser with or without a photosensitizer was administered to an NR-S1 carcinoma in the mouse dorsum.
  
  
  RESULTS
  Photodynamic therapy with high-power laser irradiation yielded better results than conventional photodynamic therapy or hyperthermia with high-power laser irradiation.
  
  
  CONCLUSIONS
  Photodynamic therapy with high-power laser irradiation is more effective because it generates both a hyperthermic and a photodynamic effect.
authors.affiliation: Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Inokuchi
authors.forename: K
authors.initials: K
authors.lastname: Sano
mesh_terms: D000538:Aluminum Silicates; D000818:Animals; D000963:Antimetabolites; D001973:Bromodeoxyuridine; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000627:therapeutic use; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009336:Necrosis; D009354:Neodymium; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy*; D015019:Yttrium
chemical_list: D000538:Aluminum Silicates; D000963:Antimetabolites; D006415:Hematoporphyrins; D017319:Photosensitizing Agents; D009354:Neodymium; D015019:Yttrium; D001973:Bromodeoxyuridine