[Axonal Guillain-Barré syndrome associated with anti-GalNAc-GD1a antibody subsequent to Campylobacter jejuni (PEN 43) enteritis].
We reported a 16-year-old boy who had Guillain-Barré syndrome (GBS) after suffering diarrhea. Campylobacter jejuni was isolated from his stool, and the serotype belonged to PEN 43. Neurologic examination revealed distal-dominant muscle weakness atrophy, and mild sensory disturbance. Motor and sensory nerve conduction velocities were normal, but compound muscle action potentials were markedly reduced. Serum from the patient had high titers of anti-FalNAc-GD1a antibodies. He had HLA-A24, B51, DRB1*04 and DRB1*09. His elder sister showed diarrhea and serum anti-C. jejuni antibody, but did not showed GBS and serum anti-ganglioside antibody. Her HLA types were A24, B51, DRB1*09 and DRB1*14.
Ihara
Y
Y
Clinical Research Institute, National Minamiokayama Hospital.
Saito
K
K
Yoshimoto
S
S
Hayabara
T
T
Yuki
N
N
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis*; D002169:Campylobacter Infections; D016123:Campylobacter jejuni / Q000145:classification / Q000302:isolation & purification*; D004751:Enteritis / Q000382:microbiology*; D005732:Gangliosides / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D011129:Polyradiculoneuropathy / Q000382:microbiology*; D012703:Serotyping
D000907:Antibodies, Bacterial; D005732:Gangliosides; C055253:IV(4)-galactosyl-N-acetylganglioside GD1a