Calcium transport pathways in the nucleus.
Due to the availability of new biophysical and biochemical techniques, there has recently been considerable progress in our understanding of Ca2+ transport inside, as well as into and out of, the nucleus. A number of Ca2+ transport pathways have been localized specifically in the outer or inner nuclear membrane and the Ca2+ permeability through the nuclear pore complex has been assessed. The nuclear envelope has characteristics similar to those of a leaky epithelium. The leak is through the nuclear pore complex. The outer nuclear membrane contains the Ca2+ ATPase whereas the functionally important inositol trisphosphate (IP3)-activated Ca2+ release channels are specifically localized in the inner nuclear membrane.
Gerasimenko
O V
OV
MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, P.O. Box 147, Liverpool, L69 3BX, UK.
Gerasimenko
J V
JV
Tepikin
A V
AV
Petersen
O H
OH
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism
D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium