Candida albicans meningitis in a 27 weeks premature infant treated with liposomal amphotericin-B (AmBisome)
We report a case of Candida albicans meningitis in a neonate born after 27 weeks of gestation. To the best of our knowledge this is the first report of a premature infant with Candida-meningitis treated with liposomal amphotericin B (AmBisome(R)). The patient did not respond well to conventional Amphotericin B, but was successfully cured with Ambisome(R). Liposomal amphotericin B was well tolerated and the baby recovered with a postinfectious hydrocephalus which necessitated a permanent ventriculo-peritoneal shunt. Six months after the infection the baby appears to have a near-normal cerebral development.
Jarløv
J O
JO
Department of Clinical Microbiology, National University Hospital (Rigshopitalet), Copenhagen, Denmark.
Born
P
P
Bruun
B
B
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D016921:Meningitis, Fungal / Q000175:diagnosis / Q000188:drug therapy*
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B