Effects of vitamin D3 injection on activity of thyroid parafollicular cells in pregnant rats.
Effects of vitamin D3 (VD3) injection on the activity of thyroid parafollicular cells (C cells) and calcium (Ca) metabolism were examined in rats of non-(NP), middle (MP) and late pregnancy (LP). At 3 days after injection, the average area of a C cell was significantly wider (P<0.01) in the VD3 groups than that in their control groups in NP, MP, and LP. On the otherhand, the plasma ca concentration in the VD3 groups decreased significantly (P<0.05) in comparison with that in their control groups in NP and LP, and tended to decrease in MP. These results suggest that injection of VD3 may accelerate the activity of C cells, which may result in the decrease of plasma Ca concentration in both non-pregnant and pregnant rats.
Won
J H
JH
Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University, Japan.
Taniguchi
K
K
Sato
R
R
Naito
Y
Y
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002762:Cholecalciferol / Q000494:pharmacology*; D005260:Female; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D010281:Parathyroid Hormone; D010710:Phosphates; D002762:Cholecalciferol; D002118:Calcium