title: Visceral ischemia and organ dysfunction after thoracoabdominal aortic aneurysm repair. A clinical and cost analysis.
abstract: OBJECTIVE
  Repair of thoracoabdominal aortic aneurysms (TAAAs) is associated with significant postoperative morbidity and mortality. Reperfusion of acutely ischemic abdominal viscera in animals leads to release of multiple factors that cause local and distant organ damage, and similar phenomena occurring in humans after TAAA repair could contribute to the high morbidity/mortality and cost associated with this procedure.
  
  
  METHODS
  Twenty-nine patients undergoing elective TAAA repair were studied prospectively. Preoperative organ dysfunction and intraoperative risk factors (cross-clamp time, blood loss, operative time) were assessed and compared with postoperative organ dysfunction (defined as: pulmonary, positive pressure ventilation for > 7 days; renal, increase in serum creatinine > 2.0 mg/dL over baseline; hepatic, lactate dehydrogenase > 500 international units and total bilirubin > 3.0 mg/dL or serum transaminase level > 200 international units; hematopoietic, platelet count > 50 K or leukocyte count > 4.5 K, mortality, and costs.
  
  
  RESULTS
  No relationship between preoperative organ dysfunction, blood loss, or operative time and postoperative organ dysfunction or mortality was seen; however, cross-clamp times > 40 minutes were associated with a significantly greater incidence of pulmonary (59%), renal (47%), hepatic (35%), and hematopoietic (47%) dysfunction. In addition, multiple-organ dysfunction (> 2 organ systems) was more common after > 40 minutes of visceral ischemia and led to significantly greater overall hospital ($88,465 + $76,155 vs. $41,782 + $31,244) and intensive care unit ($26,726 + $28,256 vs. $11,234 + $12,146) costs (p < 0.01, Mann-Whitney U test). Mortality associated with leukopenia was 67% compared with 4% without leukopenia (p < 0.01).
  
  
  CONCLUSIONS
  Increasing durations of acute visceral ischemia led to significant multiple organ dysfunction after TAAA repair. Methods of limiting visceral ischemia or the systemic effects of visceral ischemia may decrease both the morbidity and mortality and the overall hospital cost associated with this procedure.
authors.affiliation: University of Florida College of Medicine, Department of Surgery, Gainesville, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Harward
authors.forename: M B
authors.initials: MB
authors.lastname: Welborn
authors.forename: T D
authors.initials: TD
authors.lastname: Martin
authors.forename: T C
authors.initials: TC
authors.lastname: Flynn
authors.forename: T S
authors.initials: TS
authors.lastname: Huber
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
authors.forename: J M
authors.initials: JM
authors.lastname: Seeger
mesh_terms: D000005:Abdomen / Q000098:blood supply*; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D016063:Blood Loss, Surgical; D005260:Female; D017721:Hospital Costs; D006801:Humans; D007511:Ischemia / Q000191:economics / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000191:economics / Q000209:etiology*; D011183:Postoperative Complications / Q000191:economics; D011446:Prospective Studies; D012307:Risk Factors