title: Radon in Devon and Cornwall and paediatric malignancies.
abstract: Exposure to radon in dwellings may cause cancer including paediatric malignancies. Devon and Cornwall have the highest exposure to radon of the counties of England. However, within these counties there is considerable variation in exposure. Exposure to radon in the 283 postcode sectors of the two counties has been published. The incidence of childhood malignancies between 1976 and 1985 was studied to compare postcode sectors of radon exposures > or = 100 Bq/m3 with sectors < 100 Bq/m3. No significant difference in the incidence rate of 106.7 per million child years in the high radon postcode sectors and 121.7 in the low (P = 0.29) was found. When the incidences of individual tumours were examined, a significantly increased rate of neuroblastoma (P = 0.02) and a non-significant increased rate of acute myeloid leukaemia were found in the high exposure postcode sectors. No association between radon exposure and overall rate of childhood malignancy was found.
authors.affiliation: Department of Paediatric Oncology, Royal Hospital for Sick Children, Bristol, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Thorne
authors.forename: N K
authors.initials: NK
authors.lastname: Foreman
authors.forename: M G
authors.initials: MG
authors.lastname: Mott
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000396:Air Pollutants, Radioactive / Q000009:adverse effects*; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D004781:Environmental Exposure; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000209:etiology; D009369:Neoplasms / Q000453:epidemiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009447:Neuroblastoma / Q000209:etiology; D011829:Radiation Dosage; D011886:Radon / Q000009:adverse effects*
chemical_list: D000396:Air Pollutants, Radioactive; D002274:Carcinogens, Environmental; D011886:Radon