Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats.
While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) injection of L-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the i.pl. injection of either the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (10 nmol) or the competitive alpha-amino-3-hydroxy-4-methyl-5-isoxazolepropionic acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)(100 nmol) into hindpaws inflamed with carrageenan significantly reduced the thermal hyperalgesic response in rats. Collectively, these results suggest that excitatory amino acids activate a peripheral target which facilitates a hyperalgesic behavioural response to thermal stimulation via a receptor mediated process.
Jackson
D L
DL
Department of Restorative Sciences, School of Dentistry, University of Minnesota, Minneapolis 55455, USA.
Graff
C B
CB
Richardson
J D
JD
Hargreaves
K M
KM
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology*; D006358:Hot Temperature; D006930:Hyperalgesia; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D018698:Glutamic Acid; D016291:Dizocilpine Maleate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione