title: [Adrenal adenoma or hyperplasia? Problems of differential diagnosis in an unusual case of primary hyperaldosteronism].
abstract: Although primary hyperaldosteronism is an uncommon cause of hypertension, it is the most common form of renin-independent hypermineralocorticoidism. The plasma aldosterone concentration and PRA with orthostatic test and saline infusion test are very useful aids to make a diagnosis. In this case the inconsistency between hormonal data and morphologic images (TC and NMR) led us to a dilemma: it was a question of adrenal adenoma or hyperplasia? Because it was impossible to dose the 18-OH-corticosterone, we had to perform a iodocholesterol scintigraphy NP 59. To distinguish an hyperplasia as cause of this kind of hyperaldosteronism made us able to define a therapeutic program useful to hypertension control.
authors.affiliation: Dipartimento di Medicina Sperimentale Università degli Studi di Roma La Sapienza, Roma.
authors.forename: A L
authors.initials: AL
authors.lastname: Sanna
authors.forename: T
authors.initials: T
authors.lastname: Ciampani
authors.forename: G
authors.initials: G
authors.lastname: Mancini
authors.forename: D
authors.initials: D
authors.lastname: Giannini
authors.forename: V
authors.initials: V
authors.lastname: Bonifacio
mesh_terms: D015069:18-Hydroxycorticosterone / Q000097:blood; D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology*; D000450:Aldosterone / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006965:Hyperplasia; D006973:Hypertension / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000450:Aldosterone; D015069:18-Hydroxycorticosterone
vernacular_title: Adenoma surrenalico o iperplasia? Problemi di diagnostica differenziale in un caso inusuale di iperaldosteronismo primitivo.