Polyserositis as an unusual sign of methotrexate toxicity.
We present a 46-year-old patient who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy for persistent trophoblastic disease. Single-agent chemotherapy with alternate methotrexate 1 mg/kg/day and leucovorin 0.1 mg/kg for 8 days was instituted on the first postoperative day. Various adverse symptomatology developed, culminating in a unique side effect, polyserositis. To the best of our knowledge, the wide spectrum of side effects, the short time lapse after onset of chemotherapy, and their severity are uncommon in a patient receiving her first chemotherapeutic treatment with MTX.
Klein
Z
Z
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.
Altaras
M
M
Beyth
Y
Y
Fishman
A
A
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D011247:Pregnancy; D012700:Serositis / Q000139:chemically induced*; D014328:Trophoblastic Neoplasms / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000188:drug therapy
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate