title: [Cyclosporin A and the permeability of the cytoplasmic membrane in Aspergillus niger].
abstract: Cyclosporine A was shown to impair selective permeability of cytoplasmic membranes in Aspergillus niger thus inducing leakage of low molecular components of the intracellular fond from the cells. In this respect lyposomal cyclosporine had a more pronounced action than the free form. Cyclosporine was compared with amphotericin B and the latter in the free and lyposomal forms demonstrated a higher effect on the cell membranes of Asp. niger. In combination with amphotericin B cyclosporine markedly stimulated the effect of amphotericin B on permeability of the cell membranes.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Sazykin
authors.forename: G N
authors.initials: GN
authors.lastname: Telsnina
authors.forename: P L
authors.initials: PL
authors.lastname: Zaslavskaia
authors.forename: T V
authors.initials: TV
authors.lastname: Lasova
authors.forename: V P
authors.initials: VP
authors.lastname: Ivanov
authors.forename: E Sh
authors.initials: ESh
authors.lastname: Elkina
authors.forename: S M
authors.initials: SM
authors.lastname: Navashin
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D003593:Cytoplasm / Q000187:drug effects* / Q000648:ultrastructure; D004337:Drug Carriers; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D008081:Liposomes; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D008970:Molecular Weight; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; D007166:Immunosuppressive Agents; D008081:Liposomes; D000666:Amphotericin B; D016572:Cyclosporine
vernacular_title: Tsiklosporin A i pronitsaemost' tsitoplazmaticheskoĭ membrany Aspergillus niger.