title: Efficacy of an ivermectin and pyrantel pamoate combination against adult hookworm, Ancylostoma braziliense, in dogs.
abstract: A chewable tablet incorporating ivermectin and pyrantel was tested in 12 Beagle dogs for efficacy against the adult hookworm, Ancylostoma braziliense. The dogs were administered infective larvae of A braziliense orally. Twenty-one days after infection the dogs were weighed and allocated randomly to receive either an oral treatment with ivermectin and pyrantel in a beef-based chewable tablet or no treatment. The chewable tablet was a commercially available product, which was made to deliver ivermectin at 6 micrograms/kg and pyrantel at 5.0 mg/kg to each dog. Seven days after treatment the dogs were euthanased, necropsied, and examined for adult hookworms. At necropsy, no adult A braziliense was observed in any of the 6 treated dogs and all 6 dogs that had been left untreated were infected with adult A braziliense (range, 48 to 161). It was concluded that this combination product is 100% efficacious against adult A braziliense.
authors.affiliation: Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Shoop
authors.forename: B F
authors.initials: BF
authors.lastname: Michael
authors.forename: M D
authors.initials: MD
authors.lastname: Soll
authors.forename: J N
authors.initials: JN
authors.lastname: Clark
mesh_terms: D000284:Administration, Oral; D000722:Ancylostoma / Q000302:isolation & purification; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D005260:Female; D007421:Intestine, Small / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D000969:Antinematodal Agents; D000977:Antiparasitic Agents; D007559:Ivermectin; D011716:Pyrantel Pamoate