title: Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization.
abstract: We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6(0.14%). No differences were found among the individuals analysed.
authors.affiliation: Unitat de Biologia Cellular, Facultat de Ciències, Universitat Autònoma Barcelona, Bellaterra, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Blanco
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
authors.forename: F
authors.initials: F
authors.lastname: Vidal
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D013094:Spermatozoa / Q000473:pathology* / Q000648:ultrastructure