title: [The ability of hemoglobin and myoglobin to evoke a spasm of the smooth musculature and to accelerate thrombocyte destruction. A description of serotonin-ferroprotein receptors].
abstract: The previously unknown properties of ferroproteins (hemoglobin and myoglobin) to cause smooth muscle spasm and to accelerate platelet degradation are described in the paper. Ferroproteins are shown to interact with some serotonin receptors. Some serotonin receptors of smooth muscles and platelets which hemoglobin and myoglobin interact with are termed serotonin-ferroprotein receptors (S-Fe-pr-receptors). The found properties of ferroproteins provide a deep insight into the understanding of physiological and pathophysiological processes with the participation of hemoglobin, myoglobin, platelets, smooth muscles, serotonin, and serotonin receptors.
authors.forename: A P
authors.initials: AP
authors.lastname: Simonenkov
authors.forename: V D
authors.initials: VD
authors.lastname: Fedorov
authors.forename: A V
authors.initials: AV
authors.lastname: Fedorov
authors.forename: V A
authors.initials: VA
authors.lastname: Stupin
authors.forename: M L
authors.initials: ML
authors.lastname: Zhirnikova
authors.forename: E K
authors.initials: EK
authors.lastname: Iunin
authors.forename: S A
authors.initials: SA
authors.lastname: Kondakov
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D006454:Hemoglobins / Q000494:pharmacology*; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009211:Myoglobin / Q000494:pharmacology*; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D013035:Spasm / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D009211:Myoglobin; D011956:Receptors, Cell Surface; D011985:Receptors, Serotonin; C098707:serotonin-ferroprotein receptor; D012701:Serotonin
vernacular_title: Sposobnost' gemoglobina i mioglobina vyzyvat' spazm gladkoĭ muskulatury i uskoriat' razrushenie trombotsitov. Opisanie serotonin-ferroproteinovykh retseptorov.