title: A new region of conservation is defined between human and mouse X chromosomes.
abstract: Comparative mapping of the X chromosome in eutherian mammals has revealed distinct regions of conservation as well as evolutionary rearrangements between human and mouse. Recently, we and others mapped the murine homologue of CLCN4 (Chloride channel 4) to band F4 of the X chromosome in Mus spretus but to chromosome 7 in laboratory strains. We now report the mapping of the murine homologues of APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), two genes that are located on the human X chromosome at band p22. 3 and in close proximity to CLCN4. Interestingly, Oa1 and Apxl map to bands F2-F3 in both M. spretus and the laboratory strain C57BL/6J, defining a new rearrangement between human and mouse X chromosomes.
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington, 98195, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Dinulos
authors.forename: M T
authors.initials: MT
authors.lastname: Bassi
authors.forename: E I
authors.initials: EI
authors.lastname: Rugarli
authors.forename: V
authors.initials: V
authors.lastname: Chapman
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
authors.forename: C M
authors.initials: CM
authors.lastname: Disteche
mesh_terms: D016117:Albinism, Ocular / Q000235:genetics*; D000818:Animals; D018118:Chloride Channels / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D019143:Evolution, Molecular; D015321:Gene Rearrangement; D005819:Genetic Markers; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D008840:Microfilament Proteins; D009115:Muridae / Q000235:genetics; D013045:Species Specificity; D014960:X Chromosome / Q000235:genetics* / Q000648:ultrastructure
chemical_list: C097503:CLC-5 chloride channel; C484312:CLCN4 protein, human; D018118:Chloride Channels; D005819:Genetic Markers; D008565:Membrane Proteins; D008840:Microfilament Proteins; C101060:SHROOM2 protein, human; C484418:Shroom2 protein, mouse