title: Trypanosoma congolense infection in sheep: ultrastructural changes in the skin prior to development of local skin reactions.
abstract: Events occurring in the skin of sheep prior to development of Trypanosoma congolense-induced local skin reactions (chancres) were studied using electron microscopy. Three days after infection, few trypanosomes were present in the dermal collagen. However, these parasites were more abundant 5 days after infection, and were also found in dermal lymphatics and in the connective tissue matrix between collagen bundles. Mast cells in the skin obtained 5 days after infection showed evidence of degranulation. These events may play a role during the induction phase of trypanosomal chancres.
authors.affiliation: Centre for Tropical Veterinary Medicine, University of Edinburgh, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Mwangi
authors.forename: J
authors.initials: J
authors.lastname: Hopkins
authors.forename: A G
authors.initials: AG
authors.lastname: Luckins
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D008407:Mast Cells / Q000469:parasitology / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D012756:Sheep; D012757:Sheep Diseases; D012867:Skin / Q000469:parasitology / Q000473:pathology / Q000648:ultrastructure*; D012876:Skin Diseases, Parasitic / Q000473:pathology / Q000662:veterinary*; D013997:Time Factors; D014348:Trypanosoma congolense / Q000302:isolation & purification; D014353:Trypanosomiasis, African / Q000473:pathology / Q000662:veterinary*
chemical_list: D003094:Collagen