title: Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice.
abstract: The carcinogenic potential of tamarind seed polysaccharide was examined in both sexes of B6C3F1 mice. Groups of 50 male and 50 female animals were given diets containing 0, 1.25 and 5% of tamarind seed polysaccharide for 78 wk. Body weight retardation was exhibited by the females in the 1.25 and 5% groups from 34 wk to termination. However, there were no treatment-related clinical signs or adverse effects on survival rate, food and water consumption, haematology findings or organ weights. Detailed histopathological examination also revealed no treatment-related increase in the incidence of any non-neoplastic or neoplastic lesions. These results demonstrated that tamarind seed polysaccharide is not carcinogenic in B6C3F1 mice of either sex.
authors.affiliation: First Department of Pathology, Nagoya City University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sano
authors.forename: E
authors.initials: E
authors.lastname: Miyata
authors.forename: S
authors.initials: S
authors.lastname: Tamano
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Shirai
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009369:Neoplasms / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000633:toxicity*; D012639:Seeds / Q000737:chemistry; D015996:Survival Rate; D018675:Toxicity Tests; D014197:Trees
chemical_list: D011134:Polysaccharides