Alterations in surface morphology of Candida albicans produced by rilopirox: a scanning electron microscopy study.
The topological changes produced in Candida albicans cells by incubation in vitro with rilopirox have been investigated by scanning electron microscopy. Rilopirox is a new hydroxypyridone compound with fungicidal activity and the effects of 1x MIC (2.9 micrograms/ml) and 4 x MIC (11.6 micrograms/ml) after 1, 12, 24 hours of incubation were evaluated. The morphological alterations produced by rilopirox are round shapes, collapsed cells, surface folds, clusters, holes and thorn-like extrusion. The effects of rilopirox are already evident at 1 x MIC and after 1 h but their frequency and severity are correlated with the time of incubation and the MIC.
Braga
P C
PC
Department of Pharmacology, University of Milan, Italy.
Maci
S
S
Dal Sasso
M
M
Piatti
G
G
Bohn
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011728:Pyridones / Q000494:pharmacology*
D000935:Antifungal Agents; D011728:Pyridones; C066307:rilopirox