Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus.
IDDM in Singaporean Chinese was associated with HLA B58, DRB1*0301, DQB1*0201, and joint occurrences of DRB1*0301/*0901 and DRB1*0301/*04. Of the DR4s the frequencies of DRB1*0401, *0404, and *0405 were higher and *0406 was lower in patients compared to controls. DRB1*0301/*0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1*0301/*04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1*1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQ beta chains and a lower frequency of homozygous Asp57 DQ beta chains compared to controls, especially in younger onset patients.
Chan
S H
SH
Department of Microbiology, WHO Immunology Centre, National University of Singapore.
Thai
A C
AC
Lin
Y N
YN
Liu
K F
KF
Wee
G B
GB
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D006680:HLA Antigens