[Regularities of drug desorption from soft contact lenses. 2. In vitro study].
Radiometry of distribution of drugs introduced with soft contact lenses (with 40 and 70% humor content and thickness of 0.2 and 0.7 mm) in the ocular cavity was carried out to compare this mode of drug administration with the traditional methods. The maximal concentrations of the drugs in the anterior chamber humor and in the vitreous body were attained by using saturated highly hydrophilic 0.7 mm thick contact lenses. The drug content in the anterior chamber of the eye upon such a mode of administration was higher than after injection and much higher than after instillation.
Rybakova
E G
EG
Avetisov
S E
SE
Badun
G A
GA
Krasnianskiĭ
A V
AV
D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001285:Atropine / Q000008:administration & dosage / Q000493:pharmacokinetics; D003263:Contact Lenses, Hydrophilic; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D009184:Mydriatics / Q000008:administration & dosage / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005839:Gentamicins; D009184:Mydriatics; D004364:Pharmaceutical Preparations; D001285:Atropine; D003907:Dexamethasone
Zakonomernosti desorbtsii lekarstvennykh preparatov iz miagkikh contaktnykh linz. Soobshchenie 2. Issledovaniia in vitro.