title: Fluconazole failure in two cases of disseminated candidosis.
abstract: Amphotericin B has been the standard treatment of disseminated candidosis although the less toxic fluconazole tends to be used more frequently. In a recent report, no significant difference in the efficacy of candidaemia treatment was observed between fluconazole and amphotericin B. However, we report on 2 cases of invasive candidosis where fluconazole failed to eradicate Candida albicans although the isolates were susceptible to fluconazole in vitro. Pulsed-field gel electrophoresis was used to confirm the persistence of the same C. albicans strain after therapy failure in both patients.
authors.affiliation: Department of Infectious Diseases, Orebro Medical Center, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Jahnson
authors.forename: E
authors.initials: E
authors.lastname: Chryssanthou
authors.forename: B
authors.initials: B
authors.lastname: Petrini
authors.forename: T
authors.initials: T
authors.lastname: Vikerfors
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole