Chronic postnatal phencyclidine treatment on [3H](+) pentazocine binding in juvenile rat brain.
Chronic phencyclidine (PCP) administrations in postnatal rats produce long-term behavioral changes. Here we report the effects of repeated postnatal PCP treatment on [3H](+)pentazocine binding in juvenile rats. Saturation analyses of the binding data showed no significant difference in any of the binding characteristics between chronic PCP-related rats and saline-treated controls suggesting that mechanisms other than alterations in sigma1 binding underlie the behavioral effects of repeated postnatal PCP administration in immature rats.
Sircar
R
R
Department of Psychiatry and Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
He
H J
HJ
Li
C S
CS
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D010423:Pentazocine / Q000378:metabolism*; D010622:Phencyclidine / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014316:Tritium
D006213:Hallucinogens; D014316:Tritium; D010622:Phencyclidine; D010423:Pentazocine