[Hepatitis attributed to the use of terbinafine].
A 71-year-old woman was admitted to our hospital with jaundice after she had been using terbinafine for a few weeks. The liver function tests showed a mixed cholestatic-hepatocellular pattern. A liver biopsy revealed large amounts of intracellular bile pigment. Causes of the liver disorder other than the use of the aforementioned antimycotic drug were excluded. Ten months after cessation of the drug the patient had recovered completely. The Netherlands Inspectorate for Health Care received 20 reports of liver enzyme elevations due to terbinafine in 1991-1994.
Boldewijn
O Y
OY
Afd. Inwendige Geneeskunde, Rijnlandziekenhuis, Leiderdorp.
Ottervanger
J P
JP
Mostart
C M
CM
Janssens
A R
AR
Calame
J
J
Jonkers
G J
GJ
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects*; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D014009:Onychomycosis / Q000188:drug therapy; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine
Hepatitis toegeschreven aan het gebruik van terbinafine.