CD30 ligand is expressed on resting normal and malignant human B lymphocytes.
CD30, a member of the tumour necrosis receptor superfamily, is physiologically expressed on a subpopulation of T helper cells in normal individuals but is also expressed on several malignant and virally transformed cells. Its ligand (CD30L) is a pleiotropic cellular transmembrane protein that can induce cell death in several CD30+ cell lines. CD30L expression has been reported on activated human peripheral blood T lymphocytes and macrophages but not on B cells. Here we show that the CD30L is expressed on resting normal and on malignant B cells in addition to both CD4+ and CD8+ subsets of activated T cells, making it the second tumour necrosis family member, in addition to the CD27 ligand, that can be expressed on both T and B cells. These findings raise the possibility that the CD30L has a role in B-cell/T-cell communication and that B and T cells are likely to be involved in the growth regulation of CD30+ tumours.
Younes
A
A
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Consoli
U
U
Zhao
S
S
Snell
V
V
Thomas
E
E
Gruss
H J
HJ
Cabanillas
F
F
Andreeff
M
M
D001402:B-Lymphocytes / Q000378:metabolism*; D001483:Base Sequence; D053285:CD30 Ligand; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
D053285:CD30 Ligand; D008024:Ligands; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; C505774:TNFSF8 protein, human