The presence of Epstein-Barr virus in multiple organs in a fatal case of virus-associated haemophagocytic syndrome.
We describe a case report of a 21-year-old male with fatal Epstein-Barr virus-associated haemophagocytic syndrome. Virus is detected in multiple organs by polymerase chain reaction and in the tissue-specific cells of those organs by in situ hybridisation. It is suggested that organ failure may be a direct response to infection.
Pringle
J H
JH
Department of Pathology, University of Leicester Medical School, U.K.
Primrose
L
L
Myint
S H
SH
D000328:Adult; D001483:Base Sequence; D017809:Fatal Outcome; D006566:Herpesviridae Infections / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000821:virology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data