Testosterone decreases lipoprotein(a) in men.
We administered testosterone, with or without the aromatase inhibitor testolactone, to determine the effects of testosterone and its aromatization to estradiol on Lp(a) levels in normal men. Average Lp (a) values decreased by 37% during testosterone alone and by 28% when testosterone and testolactone were combined, suggesting that testosterone reduces Lp(a) in men primarily by an androgenic effect and not by its conversion to estradiol.
Zmunda
J M
JM
Division of Cardiology, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thompson
P D
PD
Dickenson
R
R
Bausserman
L L
LL
D000328:Adult; D018592:Cross-Over Studies; D004958:Estradiol / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000187:drug effects*; D008297:Male; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology*
D017270:Lipoprotein(a); D013739:Testosterone; D004958:Estradiol