title: Dietary fatty acids, low density lipoprotein composition and oxidation and primate atherosclerosis.
abstract: Low density lipoproteins (LDL) were isolated from nonhuman primates fed isocaloric diets rich in different types of fatty acids. These diets contained 35% of calories as fat enriched in fatty acids from the following sources: lard that is rich in saturated fatty acids, safflower oil rich in oleic acid, safflower oil rich in linoleic acid and menhaden oil that is rich in n-3 fatty acids. LDL composition reflected the dietary fats. LDL were subjected to oxidation using copper ions and azobis(2-amidinopropane) x 2HCl. In general, the sensitivity of LDL to oxidation depended on both the poly-unsaturated fatty acid and vitamin E content. However, the lag times calculated for the copper ion catalyzed oxidations did not show the linear dependence on vitamin E content that was found for azobis(2-amidinopropane) catalyzed oxidation.
authors.affiliation: Department of Biochemistry, Wake Forest University Medical Center, The Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Thomas
authors.forename: L L
authors.initials: LL
authors.lastname: Rudel
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D004041:Dietary Fats / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis*; D008077:Lipoproteins, LDL / Q000032:analysis* / Q000378:metabolism; D008252:Macaca fascicularis; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000032:analysis
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008077:Lipoproteins, LDL; D014810:Vitamin E