[The efficacy of emoxipin and neoton in unstable stenocardia].
55 patients with unstable angina pectoris (group 1) received conventional treatment and neoton infusions (30 g/day for 3 days). Emoxipin was injected intramuscularly to 20 patients of group 2 (3 mg/kg for 20 days) and intravenously to 38 patients of group 3 (10 mg/kg). Control group consisted of 100 patients. Stabilization occurred in 89.2, 80 and 86.8% of group 1, 2 and 3 patients, respectively, versus 78% in controls. Holter ECG monitoring provided evidence on decline of myocardial ischemia for group 1 patients. Diene conjugates in group 1 decreased by 37%, ceruloplasmin level was higher by 30% compared to controls. Respective indices for emoxipin reached 52 and 37%, respectively. It is concluded that emoxipin and neoton produced a beneficial effect on unstable angina pectoris through correction of lipid peroxidation.
Golikov
A P
AP
Riabinin
V A
VA
Golikov
P P
PP
Davydov
B V
BV
Polumiskov
V Iu
VIu
Rudnev
D V
DV
Taranova
Z V
ZV
D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D000975:Antioxidants / Q000627:therapeutic use*; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008875:Middle Aged; D010725:Phosphocreatine / Q000627:therapeutic use*; D010847:Picolines / Q000627:therapeutic use*
D000975:Antioxidants; D010847:Picolines; D010725:Phosphocreatine; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Effektivnost' émoksipina i neotona pri nestabil'noĭ stenokardii.