Cortical networks for visual reaching: physiological and anatomical organization of frontal and parietal lobe arm regions.
The functional and structural properties of the dorsolateral frontal lobe and posterior parietal proximal arm representations were studied in macaque monkeys. Physiological mapping of primary motor (MI), dorsal premotor (PMd), and posterior parietal (area 5) cortices was performed in behaving monkeys trained in an instructed-delay reaching task. The parietofrontal corticocortical connectivities of these same areas were subsequently examined anatomically by means of retrograde tracing techniques. Signal-, set-, movement-, and position-related directional neuronal activities were distributed nonuniformly within the task-related areas in both frontal and parietal cortices. Within the frontal lobe, moving caudally from PMd to the MI, the activity that signals for the visuo-spatial events leading to target localization decreased, while the activity more directly linked to movement generation increased. Physiological recordings in the superior parietal lobule revealed a gradient-like distribution of functional properties similar to that observed in the frontal lobe. Signal- and set-related activities were encountered more frequently in the intermediate and ventral part of the medial bank of the intraparietal sulcus (IPS), in area MIP. Movement-and position-related activities were distributed more uniformly within the superior parietal lobule (SPL), in both dorsal area 5 and in MIP. Frontal and parietal regions sharing similar functional properties were preferentially connected through their association pathways. As a result of this study, area MIP, and possibly areas MDP and 7m as well, emerge as the parietal nodes by which visual information may be relayed to the frontal lobe arm region. These parietal and frontal areas, along with their association connections, represent a potential cortical network for visual reaching. The architecture of this network is ideal for coding reaching as the result of a combination between visual and somatic information.
Johnson
P B
PB
Department of Anatomy and Cell Biology, University of North Carolina, Chapel Hill 27599, USA.
Ferraina
S
S
Bianchi
L
L
Caminiti
R
R
D000818:Animals; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology*; D008251:Macaca; D009434:Neural Pathways / Q000033:anatomy & histology*; D010296:Parietal Lobe / Q000033:anatomy & histology*; D013997:Time Factors; D014793:Visual Cortex / Q000033:anatomy & histology*