title: Synthesis and antimicrobial activity of 7 beta-(S)- and 7 beta-[(R)-3-(methyleneaminoxy)-2-methylpropionamido]substituted cephalosporanic acid derivatives.
abstract: Some 7-amino cephalosporanic acid derivatives substituted on the C(7) nitrogen with (S)-and (R)-3-(methyleneaminoxy)-2-methylpropionyl groups were synthesised and tested in vitro for their antimicrobial activity against Gram-positive and Gram-negative bacteria. Some of the new compounds showed a modest activity directed only against Gram-positive microorganisms.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Macchia
authors.forename: E
authors.initials: E
authors.lastname: Menchini
authors.forename: E
authors.initials: E
authors.lastname: Orlandini
authors.forename: A
authors.initials: A
authors.lastname: Rossello
authors.forename: G
authors.initials: G
authors.lastname: Broccali
authors.forename: M
authors.initials: M
authors.lastname: Visconti
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins