Cytomegalovirus keratitis in acquired immunodeficiency syndrome.
A man with acquired immunodeficiency syndrome developed a generalized rash and bilateral dendritic epithelial keratitis without retinitis. Cytologic examination of superficial corneal scrapings showed many megalosyncytial giant cells that were highly characteristic of cytomegalovirus (CMV) infection. Viral cultures yielded CMV from 2 separate specimens obtained by corneal epithelial debridement from both eyes. The slightly elevated, opaque, branching, nonulcerative epitheliopathy recurred after corneal scrapings and persisted despite oral and topical antiviral therapy. Stromal keratouveitis subsequently developed. This case report confirms that CMV can produce corneal involvement and suggests that CMV keratitis may be an emergent complication of acquired immunodeficiency syndrome.
Wilhelmus
K R
KR
Department of Ophthalmology Cullen Eye Institute, Baylor College of Medicine, Houston, Tex., USA.
Font
R L
RL
Lehmann
R P
RP
Cernoch
P L
PL
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D003315:Cornea / Q000473:pathology / Q000821:virology; D003319:Corneal Stroma / Q000473:pathology / Q000821:virology; D003587:Cytomegalovirus / Q000737:chemistry / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004848:Epithelium / Q000473:pathology / Q000821:virology; D015828:Eye Infections, Viral / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005347:Fibroblasts / Q000821:virology; D005469:Fluorometholone / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000166:cytology / Q000821:virology; D008297:Male
D000893:Anti-Inflammatory Agents; D000956:Antigens, Viral; D000998:Antiviral Agents; D005469:Fluorometholone; D000212:Acyclovir