title: Orthodontic management of patients with hematologic malignancies.
abstract: More than 50% of pediatric malignancies are leukemias or lymphomas. Oral changes associated with these conditions include: gingival oozing, petechiae, hematomas, ulcerations, gingival pain, gingival hypertrophy, mucosal pallor, pharyngitis, and lymphadenopathy. Current medical management for patients with hematologic malignancies includes chemotherapy, radiation, surgery, bone marrow transplantation or a combination of these modalities. Nearly 60% of patients diagnosed today with malignancy will be long-term survivors. Patients undergoing orthodontic treatment when a diagnosis of malignancy is made are best served by expedient removal of orthodontic appliances and delivery of retainers. After a patient has completed all cancer therapy and has at least a 2-year event-free survival, orthodontic treatment can be restarted.
authors.affiliation: University of Washington, Seattle, USA.
authors.forename: B
authors.initials: B
authors.lastname: Sheller
authors.forename: B
authors.initials: B
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D018572:Disease-Free Survival; D005882:Gingival Diseases / Q000209:etiology; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000628:therapy*; D008223:Lymphoma / Q000150:complications / Q000628:therapy*; D008297:Male; D008310:Malocclusion / Q000628:therapy*; D009059:Mouth Diseases / Q000209:etiology; D018704:Orthodontic Retainers; D010347:Patient Care Planning; D017741:Survivors