Identification and antisense inhibition of Na-Ca exchange in renal epithelial cells.
In summary, DCT cells express multiple isoforms of the Na-Ca exchanger and exhibit functional exchange, and antisense oligonucleotides to a downstream region of the exchanger transcript inhibit activity. These experiments provide direct evidence for Na-Ca exchange in DCT cells mediated by NACA2, NACA3, or NACA6.
White
K E
KE
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755-3835, USA.
Gesek
F A
FA
Friedman
P A
PA
D017398:Alternative Splicing; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000032:analysis* / Q000037:antagonists & inhibitors* / Q000235:genetics; D002460:Cell Line; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism; D007668:Kidney / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D019831:Sodium-Calcium Exchanger; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D016376:Oligonucleotides, Antisense; D019831:Sodium-Calcium Exchanger; D012964:Sodium; D002118:Calcium