[Effect of mestranol on pharmacokinetics of phenazone in the rabbit].
There was studied the influence of mestranol on the pharmacokinetics parameters of phenazone. There was proved the decrease AUC abridgement the period of semi duration for elimination phase and increase total clearance. On the base of these experiments there was able to make a conclusion that estrogens influence on the phenazone's pharmacokinetic probably by induction of microsomal enzymes of liver.
Gawrońska-Szklarz
B
B
Zakładu Farmakologii Klinicznej PAM w Szczecinie.
Droździk
M
M
Kwiatkowski
A
A
Wójcicki
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D000983:Antipyrine / Q000493:pharmacokinetics*; D045166:Estradiol Congeners / Q000494:pharmacology*; D008656:Mestranol / Q000494:pharmacology*; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D018709:Statistics, Nonparametric
D000894:Anti-Inflammatory Agents, Non-Steroidal; D045166:Estradiol Congeners; D008656:Mestranol; D000983:Antipyrine
Wpływ mestranolu na farmakokinetyke fenazonu u królic.