title: Ornithine decarboxylase in Paracoccidioides brasiliensis.
abstract: Ornithine decarboxylase in Paracoccidioides brasiliensis, a dimorphic human pathogenic fungus, was more active at 37 degrees C in the yeast phase and at 30 degrees C in the mycelial phase. In contrast to other fungal systems, yeast growth and mycelium-to-yeast transition in P. brasiliensis were accompanied by a high activity of ornithine decarboxylase at the onset of the budding process, the activity of which was inhibited by 1,4-diamino-2-butanone. The activity of ornithine decarboxylase remained at a basal level during vegetative growth of both the mycelial phase and the late stage of yeast phase, and also through the yeast-to-mycelium transition.
authors.affiliation: Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Microbiología y Biología Celular, Caracas, Venezuela. gsanblas@ivic.ivic.ve/gcunto@dino.conicit.ve
authors.forename: G
authors.initials: G
authors.lastname: San-Blas
authors.forename: F
authors.initials: F
authors.lastname: Sorais
authors.forename: F
authors.initials: F
authors.lastname: San-Blas
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Herrera
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007843:Latin America; D009181:Mycoses / Q000382:microbiology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010228:Paracoccidioides / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D011700:Putrescine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; C014458:1,4-diaminobutanone; D009955:Ornithine Decarboxylase; D011700:Putrescine