Cloning of the cDNA encoding the mouse ATBF1 transcription factor.
We have isolated a mouse ATBF1 cDNA which is 12-kb long and capable of encoding a 406-kDa protein containing four homeodomains and 23 zinc-finger motifs. Mouse ATBF1 is 94% homologous to the human ATBF1-A transcription factor. Northern blot and RNase protection analysis showed that levels of ATBF1 transcripts were low in adult mouse tissues, but high in developing brain, consistent with a role for ATBF1 in neuronal differentiation.
Ido
A
A
Department of Medical Biochemistry, University of Calgary, Alberta, Canada.
Miura
Y
Y
Watanabe
M
M
Sakai
M
M
Inoue
Y
Y
Miki
T
T
Hashimoto
T
T
Morinaga
T
T
Nishi
S
S
Tamaoki
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics*; D005801:Genes, Homeobox; D018398:Homeodomain Proteins; D006801:Humans; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009928:Organ Specificity; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic; D016335:Zinc Fingers
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C489511:Zfhx3 protein, mouse; C489512:Zfhx3 protein, rat; C071660:ZFHX3 protein, human