title: [Test for the effects of mutagenic toxic fungal metabolites originating from municipal landfill sites].
abstract: The purpose of the study is to assess the mutagenic effect of mycotoxins produced by moulds growing on municipal landfill sites. Mutagenicity of toxic fungal metabolites was determined by the Salmonella plate incorporation assay with two strains of bacteria: TA98 and TA100, with and without metabolic activation. The results obtained indicate that there is a severe hazard caused by these mycotoxins detected main by TA98 with metabolic activation. The most mutagenic mixture of mycotoxins acting directly on both strains was produced by Aspergillus nidulans. The highest mutagenic effect detected by TA98 with metabolic activation was found in the mixture of mycotoxins produced by one of three isolated Aspergillus fumigatus varieties.
authors.affiliation: Pracowni Mutagenezy Srodowiskowej, Instytutu Medycyny Pracy i Zdrowia Srodowiskowego w Sosnowcu.
authors.forename: A
authors.initials: A
authors.lastname: Bubak
authors.forename: D
authors.initials: D
authors.lastname: Mielzyńska
authors.forename: E
authors.initials: E
authors.lastname: Siwińska
authors.forename: K
authors.initials: K
authors.lastname: Ulfig
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D004784:Environmental Monitoring; D015386:Hazardous Substances / Q000032:analysis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis*; D009183:Mycotoxins / Q000096:biosynthesis*; D012037:Refuse Disposal; D013045:Species Specificity
chemical_list: D015386:Hazardous Substances; D009153:Mutagens; D009183:Mycotoxins
vernacular_title: Badanie efektu mutagennego metabolitów grzybów toksynotwórczych pochodzacych z wysypiska odpadów komunalnych.