[Lipoprotein(a)--atherogenic waste product of evolution?].
Lipoprotein(a) (Lp[a]) consists of a LDL-particle and an apolipoprotein(a) which is related to plasminogen. The physiological function of Lp(a) is largely unknown, but the clinical effects are well known: high plasma concentrations of Lp(a) correlate with a high risk for atherosclerosis independently from other risk factors. This was shown in several studies for coronary heart disease, stroke and peripheral atherosclerosis. Lp(a) has a special position within other risk factors because of the strict genetic control of the plasma concentrations by the apo(a) gene locus on chromosome 6q2.6-2.7. Studies which doubt this relationship have to be considered sceptically. Recent investigations with genetic markers confirm that Lp(a) is a risk factor for atherosclerotic vascular diseases.
Kronenberg
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F
Institut für Medizinische Biologie und Humangenetik, Universität Innsbruck.
Utermann
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G
D001161:Arteriosclerosis / Q000097:blood / Q000235:genetics*; D005075:Biological Evolution; D002896:Chromosomes, Human, Pair 6; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D012307:Risk Factors
D005819:Genetic Markers; D017270:Lipoprotein(a)
Lipoprotein(a)--atherogener Abfall der Evolution?