Epstein-Barr virus in T and natural killer (NK) cell non-Hodgkin's lymphomas.
Several studies using sensitive in situ hybridization techniques show that, in non-immunocompromised patients, Epstein-Barr virus (EBV) is more frequently detected in lymphomas expressing T cell markers than in B cell lymphomas. Among lymphomas expressing T cell markers, the presence of EBV is highly related to the site of origin of the tumor, being found in nearly all sinonasal lymphomas, in only a proportion of Waldeyer's ring, lung, gastrointestinal and nodal lymphomas, and undetectable in most primary cutaneous lymphomas. The role of EBV in their pathogenesis can be suggested in at least a proportion of extranodal lymphomas (nasal, lung, Waldeyer's ring, gastrointestinal) with T cell markers in which EBV genome is found in most if not all tumor cells (EBV-associated lymphomas) and the transforming LMP-1 protein is frequently expressed. Among these, sinonasal lymphomas constitute a distinct clinicopathologic entity which may present as lethal midline granuloma, are strongly associated with EBV and can be regarded in most cases as true NK cell lymphomas.
Kanavaros
P
P
Department of Pathology, Hôpital Henri Mondor, Creteil, France.
Briere
J
J
Emile
J F
JF
Gaulard
P
P
D014408:Biomarkers, Tumor / Q000032:analysis; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000821:virology*; D009669:Nose Neoplasms / Q000473:pathology / Q000821:virology*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000150:complications
D014408:Biomarkers, Tumor