IL-13 restores an in vitro specific cytolytic response of spleen cells from tumor-bearing rats.
In a model of colon cancer, spleen cells from tumor-bearing rats are neither cytotoxic nor proliferative in vitro in the presence of tumor cells. Interleukin-13 (IL-13) induced an in vitro cytolytic activity of spleen cells from tumor-bearing rats in response to the tumor they bore, but had no effect on spleen cells from normal rats. This cytotoxic response was dependent on both adherent and non- adherent cells, involving both an antigen-presenting activity that was enhanced by IL-13 and a cytolytic activity of lymphocytes. So, IL-13 reversed the tumor-induced immunosuppression.
Reisser
D
D
Ecole Pratique des Hautes Etudes, Cancer Immunotherapy Research Laboratory, Faculty of Medicine, Dijon, France.
Pinard
D
D
Jeannin
J F
JF
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D018793:Interleukin-13 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D014407:Tumor Cells, Cultured
D018793:Interleukin-13