title: Malignant soft tissue sarcoma of the hypopharynx successfully treated by radiotherapy alone.
abstract: Sarcoma of the hypopharynx has been reported very rarely in the literature, only six cases having been found among all head and neck malignancies reported to SEER (Surveillance, Epidemiology, and End Results) during 1973-1987. We report a 14-year-old boy with a huge malignant soft tissue sarcoma arising from the hypopharynx. Tracheostomy and feeding gastrostomy were performed as emergency life-saving procedures. Surgical resection had been attempted, but abandoned. Because of the rapidity of tumor growth, we gave the patient a course of accelerated radiotherapy (170 cGy/fraction, two fractions per day) with a total dose of 7140 cGy within one month. A series of endoscopy and imaging studies demonstrated complete regression of the tumor, and the patient is currently alive without evidence of disease 3.5 years after treatment. We conclude that for an unresectable tumor without distant metastasis, radiation therapy may be tried. The time, dose, and fractionation of radiotherapy should be carefully designed and individualized.
authors.affiliation: Department of Radiation Oncology, Taichung Veterans General Hospital, Taiwan.
authors.forename: J C
authors.initials: JC
authors.lastname: Lin
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
authors.forename: P C
authors.initials: PC
authors.lastname: Kwan
authors.forename: W C
authors.initials: WC
authors.lastname: Shen
authors.forename: J S
authors.initials: JS
authors.lastname: Jan
authors.forename: W L
authors.initials: WL
authors.lastname: Ho
mesh_terms: D000293:Adolescent; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D011879:Radiotherapy Dosage; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*