title: Long-term malaria chemoprophylaxis with mefloquine in Dutch marines in Cambodia.
abstract: Three Dutch marine battalions (n=2289) serving in Western Cambodia during 1992-1993 used mefloquine as weekly malaria chemoprophylaxis. One battalion started with a loading dose. Full compliance with prophylaxis was reported by 86.3%, and possible mefloquine-related adverse events were reported by 30.2%. Sixty-four periods of malaria were diagnosed in 59 marines. During deployment, 31 Plasmodium falciparum and no Plasmodium vivax infections occurred. After return, there were 11 cases of falciparum malaria and 22 of vivax malaria, 16-72 days and 30-540 days, respectively, after stopping prophylaxis. Mefloquine-resistant parasites were isolated from 4 Dutch and 4 Khmer patients. Long-term mefloquine prophylaxis was well tolerated but not totally effective.
authors.affiliation: Medical Service, Royal Netherlands Navy, Hilversum/Doorn.
authors.forename: A P
authors.initials: AP
authors.lastname: Hopperus Buma
authors.forename: P P
authors.initials: PP
authors.lastname: van Thiel
authors.forename: H O
authors.initials: HO
authors.lastname: Lobel
authors.forename: C
authors.initials: C
authors.lastname: Ohrt
authors.forename: E J
authors.initials: EJ
authors.lastname: van Ameijden
authors.forename: R L
authors.initials: RL
authors.lastname: Veltink
authors.forename: D C
authors.initials: DC
authors.lastname: Tendeloo
authors.forename: T
authors.initials: T
authors.lastname: van Gool
authors.forename: M D
authors.initials: MD
authors.lastname: Green
authors.forename: G D
authors.initials: GD
authors.lastname: Todd
authors.forename: D E
authors.initials: DE
authors.lastname: Kyle
authors.forename: P A
authors.initials: PA
authors.lastname: Kager
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use*; D002160:Cambodia; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control*; D016780:Malaria, Vivax / Q000517:prevention & control*; D008297:Male; D015767:Mefloquine / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D008889:Military Personnel; D009426:Netherlands
chemical_list: D000962:Antimalarials; D015767:Mefloquine