The role of angiogenesis in the spread of oral squamous cell carcinoma.
Microvessels were counted in 41 primary oral squamous cell carcinomas using JC70 antibody to PECAM (CD31). The counts were compared with clinical and pathological indicators of tumour behaviour including lymph node status, tumour stage, type of histological differentiation, size and velocity of tumour growth. Tumour microvessel counts correlated with lymph node metastasis (p < 0.001). This association was independent of tumour size, velocity and type of histological differentiation and when all the variables were analysed by multivariate analysis only vascular count showed a significant association with lymph node metastasis.
Penfold
C N
CN
Maxillofacial Unit, Queen Victoria Hospital NHS Trust, East Grinstead, London.
Partridge
M
M
Rojas
R
R
Langdon
J D
JD
D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000473:pathology; D002610:Cheek / Q000098:blood supply / Q000473:pathology; D016009:Chi-Square Distribution; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008339:Mandibular Neoplasms / Q000098:blood supply / Q000473:pathology; D009060:Mouth Floor / Q000098:blood supply / Q000473:pathology; D009062:Mouth Neoplasms / Q000098:blood supply* / Q000473:pathology*; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014062:Tongue Neoplasms / Q000098:blood supply / Q000473:pathology