Behavioural effects of the dopamine D3 receptor agonist 7-OH-DPAT in rats.
The putative selective dopamine (DA) D3 receptor agonist, 7-OH-DPAT (25-4000 micrograms kg-1), enhanced stretching-yawning and penile erection in male rats, besides respectively increasing and decreasing sedation at low (25-200 micrograms kg-1) and high (1600 and 4000 micrograms kg-1) doses and inducing stereotypy from 800 micrograms kg-1 upwards. The DA D2 antagonist, (-) eticlopride (10 and 20 micrograms kg-1), antagonized stretching-yawning and penile erection induced by a low dose of 7-OH-DPAT (50 micrograms kg-1) but not those produced by high doses (1600 and 4000 micrograms kg-1), when stereotyped behaviour, on the other hand, was potently inhibited. Comparative experiments performed with the DA agonist SND 919 gave similar results.
Ferrari
F
F
Department of Biomedical Sciences, University of Modena, Italy.
Giuliani
D
D
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D052160:Benzothiazoles; D018491:Dopamine Agonists / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010410:Penile Erection; D000077487:Pramipexole; D051381:Rats; D012457:Salicylamides / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D052160:Benzothiazoles; D018491:Dopamine Agonists; D012457:Salicylamides; D013764:Tetrahydronaphthalenes; D013844:Thiazoles; D000077487:Pramipexole; C045989:eticlopride; C031349:7-hydroxy-2-N,N-dipropylaminotetralin