title: Romifidine as a premedicant to propofol induction and infusion anaesthesia in the dog.
abstract: The effects of premedication with four different intravenous doses of romifidine (20, 40, 80 and 120 micrograms/kg bodyweight) and a saline placebo were compared in a group of 20 adult beagles of both sexes, undergoing anaesthesia with propofol for a clinical dental procedure. Anaesthesia was induced 10 minutes after premedication and maintained by intravenous infusion of propofol for a period of 30 minutes. Romifidine had a marked synergistic effect with propofol and reduced the required induction and infusion doses by more than 60 per cent for a standard level of anaesthesia; the synergistic effect was dose related. Following premedication, propofol produced no significant alteration of respiratory rate, heart rate or rectal temperature. Anaesthesia was found to be more stable following romifidine premedication at all doses studied. The quality of induction was unaltered by the dose of the romifidine. Recovery from anaesthesia was smooth and of a similar quality in all cases. There were no differences in the recovery times between the unpremedicated group and the dogs premedicated with any dose of romifidine studied. There were no adverse effects noted following this anaesthetic regimen. The marked dose-related synergism with propofol induction and infusion anaesthesia is relevant should romifidine be used in the dog in clinical veterinary practice.
authors.affiliation: Department of Large and Small Animal Medicine, Royal Veterinary College, University of London, North Mymms, Hatfield, Hertfordshire.
authors.forename: G C
authors.initials: GC
authors.lastname: England
authors.forename: F
authors.initials: F
authors.lastname: Andrews
authors.forename: R A
authors.initials: RA
authors.lastname: Hammond
mesh_terms: D000766:Anesthesia, Dental / Q000662:veterinary*; D000777:Anesthetics / Q000008:administration & dosage*; D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D011229:Preanesthetic Medication / Q000662:veterinary*; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D000777:Anesthetics; D007093:Imidazoles; C076257:romifidine; D015742:Propofol