The influence of sex hormones on UVB induced erythema in man.
Clinical and experimental evidence suggests that sex hormones can modify the inflammatory response in a number of diseases. In a pilot study the influence of sex hormones on UV-induced inflammation, testing was done with oestradiol-17beta, testosterone and progesterone, as a double-blind vehicle-controlled study in 47 healthy volunteers. Inflammation was graded using laser-doppler velocimetry. Oestradiol (5 mg/100 g) was found to increase the inflammatory response significantly when compared with placebo or testosterone treated areas (P < 0.03). These findings support previous experimental and epidemiological observations of an increased inflammation following oestrogenic stimulation, and suggest that non-lymphocyte-mediated mechanisms may be involved as well.
Jemec
G B
GB
Department of Dermatology, University of Copenhagen, Gentofte Hospital, Denmark.
Heidenheim
M
M
D000287:Administration, Topical; D000328:Adult; D004311:Double-Blind Method; D004890:Erythema / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D011374:Progesterone / Q000494:pharmacology; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000528:radiation effects; D013739:Testosterone / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects*
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol