title: Translocation of Yersinia enterocolitica through an endothelial monolayer by polymorphonuclear leukocytes.
abstract: An endothelial cell monolayer grown on a microporous membrane coated with basement membrane protein matrix was used to study translocation of yersinia-infected human polymorphonuclear leukocytes (PMNs). PMNs infected with one to eight bacteria were able to translocate living yersiniae from the upper chamber to the chemoattractant-containing lower chamber. This process may contribute to extravasation and dissemination of yersiniae in the infected host.
authors.affiliation: Institute for Hygiene and Microbiology, University of Würzburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Rüssmann
authors.forename: K
authors.initials: K
authors.lastname: Ruckdeschel
authors.forename: J
authors.initials: J
authors.lastname: Heesemann
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000382:microbiology*; D006801:Humans; D051379:Mice; D009068:Movement; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000382:microbiology* / Q000502:physiology*; D015008:Yersinia enterocolitica / Q000502:physiology*
chemical_list: D009240:N-Formylmethionine Leucyl-Phenylalanine