title: Small B cell NHL and their leukemic counterpart: differences in subtyping and assessment of leukemic spread.
abstract: Three subtypes of small lymphocytic lymphoma were studied, namely B cell chronic lymphocytic leukemia (B-CLL), mantle cell lymphoma (MCL) and follicle center lymphoma (FCL). Agreement between tissue diagnosis, based on the proposal for a revised European-American classification of lymphoid neoplasms from the International Lymphoma Study Group, and the cytomorphological diagnosis on peripheral blood and/or bone marrow smears, using the proposals for the classification of chronic (mature) B and T lymphoid leukemias of the French-American-British Cooperative Group, was studied. Full agreement was found in 90% of the CLL and 82% of the FCL cases. In MCL cases, agreement was 65% including all cases classified as intermediate/mantle zone lymphoma according to FAB criteria. The incidence of bone marrow involvement detection in trephines compared to smears was equal in CLL (both 100%) and slightly higher in MCL (56 vs 48.5%); in FCL, however, trephine biopsies provided more reliable material (71 vs 35%).
authors.affiliation: Department of Hematology, KU, Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Criel
authors.forename: S
authors.initials: S
authors.lastname: Pittaluga
authors.forename: G
authors.initials: G
authors.lastname: Verhoef
authors.forename: I
authors.initials: I
authors.lastname: Wlodarska
authors.forename: P
authors.initials: P
authors.lastname: Meeus
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: A
authors.initials: A
authors.lastname: Van Orshoven
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: M
authors.initials: M
authors.lastname: Boogaerts
authors.forename: C
authors.initials: C
authors.lastname: De Wolf-Peeters
mesh_terms: D001706:Biopsy; D002455:Cell Division; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000145:classification* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000145:classification / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D013154:Spleen / Q000473:pathology; D009626:Terminology as Topic