title: Metabolic fuel utilisation in obese women before and after weight loss.
abstract: OBJECTIVE
  To test the hypothesis that weight rebound following slimming diets may be caused by an adaptive alteration in fuel utilisation involving a suppression of fat oxidation thus favouring fat storage in adipose tissue.
  
  
  METHODS
  Repeat measurements before and after two 14 d cycles of controlled weight loss using a very low energy diet (1.9MJ/d).
  
  
  METHODS
  Eight moderately obese women (body weight: 85.6 +/- 10.1 kg, BMI: 31 +/- 2 kg/m2, age: 42.6 +/- 10.1 years).
  
  
  METHODS
  Energy expenditure and substrate balances using 24-h whole-body indirect calorimetry and naturally labelled 13C-glucose.
  
  
  RESULTS
  Aggregate weight loss was 5.1 +/- 0.8 kg. Twenty-four hour energy expenditure declined by 12% (8359 +/- 282 to 7366 +/- 191 kJ/d, p < 0.001). Net fat utilisation was not significantly depressed (4009 +/- 366) to 3613 +/- 191 kJ/d, NS), and the proportion of energy derived from fat was unchanged at 48.0% before weight loss and 49.0% after weight loss.
  
  
  CONCLUSIONS
  The well-recognised phenomenon of reduced energy expenditure is unlikely to be a major cause of weight regain. The results do not support the theory that altered fuel selection in post-obese subjects may be the cause of difficulty in maintaining weight loss.
authors.affiliation: Heller Institute of Medical Research, Sheba Medical Centre, Tel-Hashomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Burstein
authors.forename: A M
authors.initials: AM
authors.lastname: Prentice
authors.forename: G R
authors.initials: GR
authors.lastname: Goldberg
authors.forename: P R
authors.initials: PR
authors.lastname: Murgatroyd
authors.forename: M
authors.initials: M
authors.lastname: Harding
authors.forename: W A
authors.initials: WA
authors.lastname: Coward
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D002153:Calorimetry, Indirect; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism*; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats