[Metabolites of tetracycline obtained during its irradiation with visible light or peroxidase oxidation. Their toxic properties in relation to hemoglobin].
It was indicated in the literature that when exposed to visible light tetracycline induced phototoxic effects with respect to heme-containing proteins. The present study showed that when tetracycline was exposed to visible light it formed metabolites due to the photochemical transformations, the metabolites formation being slightly affected by the anti-radical drugs such as L-histidine, mannitol, ethanol and catalase. The investigation of the conditions of the metabolites formation as a result of the photochemical transformations revealed a specific role of ascorbate in the process. The comparative analysis of the physico-chemical properties of the metabolites resulting from the tetracycline exposure to visible light or peroxidase oxidation provided a conclusion that the nature of the metabolites was the same. It was shown that the metabolites were equal in their phototoxic capacity for the damage of hemoglobin by inducing its oxidative degradation.
Petrenko
Iu M
IuM
Titov
V Iu
VIu
Vladimirov
Iu A
IuA
D000818:Animals; D002374:Catalase / Q000187:drug effects; D006454:Hemoglobins / Q000187:drug effects*; D008027:Light; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D010777:Photochemistry; D011817:Rabbits; D013752:Tetracycline / Q000378:metabolism* / Q000528:radiation effects / Q000633:toxicity
D006454:Hemoglobins; D002374:Catalase; D009195:Peroxidase; D013752:Tetracycline
Metabolity tetratsiklina, poluchennye pri ego obluchenii vidimym svetom ii peroksidaznom okislenii. Ikh toksicheskie svoĭstva v otnoshenii hemoglobina.