title: Mechanisms of metal ion-dependent oxidation of human low density lipoprotein.
abstract: Although either copper or iron is essential for oxidation of human low density lipoprotein (LDL) by vascular cells, the mechanism is unknown. In our experiments copper- and iron-mediated LDL oxidation was found to proceed by different mechanisms. Oxidation of LDL by iron requires superoxide and proceeds by a hydroxyl radical-independent mechanism involving reduction of iron from the ferric to the ferrous form. In contrast, copper-mediated LDL oxidation involves direct reduction of copper from the cupric to the cuprous form by LDL.
authors.affiliation: Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, MA 02118, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Lynch
authors.forename: B
authors.initials: B
authors.lastname: Frei
mesh_terms: D003300:Copper / Q000494:pharmacology*; D006801:Humans; D017665:Hydroxyl Radical / Q000378:metabolism; D007501:Iron / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D008077:Lipoproteins, LDL; D017665:Hydroxyl Radical; D003300:Copper; D007501:Iron