Confluent and reticulated papillomatosis: response to minocycline.
BACKGROUND
Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud is an uncommon disorder of unknown cause for which a variety of treatments have been proposed.


OBJECTIVE
We attempted to evaluate the effectiveness of oral minocycline.


METHODS
Nine patients with CRP were treated with oral minocycline, 50 mg twice a day, for 6 weeks. The average follow-up period was 11 months. Recurrence rate, side effects, and effectiveness of therapy were assessed.


RESULTS
All patients except two had a 90% to 100% response to therapy. Recurrences were noted in three patients, all of whom responded to re-treatment with minocycline. None of the nine patients had an adverse reaction.


CONCLUSIONS
Minocycline, 50 mg twice a day, is safe and effective for CRP.
Montemarano
A D
AD
Department of Dermatology, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Hengge
M
M
Sau
P
P
Welch
M
M
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010212:Papilloma / Q000188:drug therapy*; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D008911:Minocycline