title: A prospective study of cognitive functions following conventional radiotherapy for supratentorial gliomas in young adults: 4-year results.
abstract: OBJECTIVE
  To evaluate the effects of limited field conventional cerebral radiotherapy (RT) on cognitive functions of adults.
  
  
  METHODS
  A prospective neuropsychological study was performed on 17 patients who underwent conventional limited field RT for a low-grade glioma or for a good-prognosis anaplastic glioma. Results were compared with 14 control patients with low-grade gliomas who did not receive radiotherapy.
  
  
  RESULTS
  A transient significant decrease of performances for the Reaction Time test was observed at 6 months in the irradiated group with return to baseline values 12 months post-RT. Subsequently, no other significant changes were observed over a 48-month follow-up period in the irradiated and nonirradiated groups. Nonetheless, when the scores of each patient were considered over time instead of the mean values of the group, one irradiated patient (5.8%) experienced progressive deterioration while two irradiated patients (11.7%) experienced long-lasting improvement. Individual changes did not occur in the control group.
  
  
  CONCLUSIONS
  This study suggests that a transient early delayed drop of neuropsychological performances at 6 months is frequent following limited field conventional RT, but the risk of long-term cognitive dysfunction after irradiation is low, at least in the first 4 years after RT and when it is administered alone in young adults.
authors.affiliation: Department of Neurology, Hôpital de la Sâlpetrière, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Vigliani
authors.forename: N
authors.initials: N
authors.lastname: Sichez
authors.forename: M
authors.initials: M
authors.lastname: Poisson
authors.forename: J Y
authors.initials: JY
authors.lastname: Delattre
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy*; D003071:Cognition / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009837:Oligodendroglioma / Q000532:radiotherapy*; D011446:Prospective Studies; D011930:Reaction Time / Q000528:radiation effects*; D015173:Supratentorial Neoplasms / Q000532:radiotherapy*; D013997:Time Factors