title: Screening for colorectal cancer with an immunological faecal occult blood test: 2-year follow-up.
abstract: This study is a 2-year follow-up of an average-risk population offered screening with both Haemoccult and Hemeselect tests to determine the interval cancer rate, and thus sensitivity. The effect on compliance with Hemeselect of testing over 1 day rather than 3 days was investigated in a separate cohort. In the first study, 3948 subjects received tests; 1489 (37.7 per cent) completed both tests and 148 had a positive result, 17 (1.1 per cent) were Haemoccult positive and 145 (9.7 per cent) were Hemeselect positive. Investigation of 142 patients revealed ten with cancer (Dukes stage A, seven; B, one; C, two). All were detected by Hemeselect but only one was Haemoccult positive. After a median follow-up of 35 (range 26-43) months, seven further patients developed colorectal cancer (stage A, one; B, three; C, three) but none followed a negative Hemeselect test (100 per cent sensitivity). In the second study 2703 subjects were offered Hemeselect tests. Compliance for testing over 1 day (48.6 per cent) was significantly better than that over 3 days (43.1 per cent) (chi 2 = 8.1, 1 d.f., P < 0.01). Hemeselect is a promising screening test for the early detection of colorectal cancer.
authors.affiliation: University Hospital, Nottingham, UK.
authors.forename: M H
authors.initials: MH
authors.lastname: Robinson
authors.forename: C G
authors.initials: CG
authors.lastname: Marks
authors.forename: P A
authors.initials: PA
authors.lastname: Farrands
authors.forename: K
authors.initials: K
authors.lastname: Bostock
authors.forename: J D
authors.initials: JD
authors.lastname: Hardcastle
mesh_terms: D000368:Aged; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005500:Follow-Up Studies; D006801:Humans; D007159:Immunologic Tests; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009780:Occult Blood; D010349:Patient Compliance; D012680:Sensitivity and Specificity