A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea.
A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAdelta must originate from a novel SAAdelta which may represent a particularly amyloidogenic variant.
Westermark
P
P
Department of Pathology I, University Hospital, Linköping, Sweden.
Sletten
K
K
Westermark
G T
GT
Raynes
J
J
McAdam
K P
KP
D000328:Adult; D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000453:epidemiology / Q000235:genetics*; D002850:Chromatography, Gel; D014644:Genetic Variation; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D010219:Papua New Guinea / Q000453:epidemiology; D010446:Peptide Fragments / Q000737:chemistry / Q000302:isolation & purification; D015995:Prevalence; D000685:Serum Amyloid A Protein / Q000737:chemistry* / Q000235:genetics*
D010446:Peptide Fragments; D000685:Serum Amyloid A Protein