title: Gastric tumorigenicity of 1,2-dimethylhydrazine on the background of gastric intestinal metaplasia induced by X-irradiation in CD (SD) rats.
abstract: Five-week-old male CD (SD) rats were X-irradiated with a total of 20 Gy in 2 equal fractions with a 3-day interval. After the second irradiation, rats were fed normal diet supplemented with 1% sodium chloride, which is known to increase intestinal metaplasia. 1,2-Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twelve months after the initial carcinogen treatment, gastric tumors in the glandular stomach were observed in 2 (3 lesions) of 30 animals in the X-irradiated and DMH-treated group fed diet supplemented with 1% sodium chloride. No gastric tumors were observed in the group which excluded X-irradiation from the experimental protocol.
authors.affiliation: Department of Cancer Research, Hiroshima University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Tatematsu
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: C
authors.initials: C
authors.lastname: Furihata
authors.forename: N
authors.initials: N
authors.lastname: Fujimoto
authors.forename: T
authors.initials: T
authors.lastname: Toge
authors.forename: A
authors.initials: A
authors.lastname: Ito
mesh_terms: D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D004127:Dimethylhydrazines; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007420:Intestine, Large / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000150:complications* / Q000209:etiology; D051381:Rats; D013270:Stomach / Q000473:pathology / Q000528:radiation effects; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000737:chemistry; D014965:X-Rays
chemical_list: D002273:Carcinogens; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine