In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system.
Chong
S
S
Dept. of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA.
Dando
S A
SA
Soucek
K M
KM
Morrison
R A
RA
D000284:Administration, Oral; D018938:Caco-2 Cells; D002352:Carrier Proteins / Q000378:metabolism*; D002463:Cell Membrane Permeability; D004058:Diffusion; D004151:Dipeptides / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D010455:Peptides / Q000493:pharmacokinetics*; D011237:Predictive Value of Tests
D002352:Carrier Proteins; D004151:Dipeptides; D010455:Peptides