Iatrogenic neonatal hypertrophic cardiomyopathy.
Transient hypertrophic cardiomyopathy is a rare sequela of both glucocorticoid and insulin excess. We report two ELBW infants who developed hypertrophic cardiomyopathy as an iatrogenic complication of the concurrent therapeutic administration of a glucocorticoid and insulin. In both cases the hypertrophic cardiomyopathy resolved completely on cessation of therapy. We advise caution when using this therapeutic combination and stress the need for regular echocardiography.
Gill
A W
AW
Department of Neonatology, John Hunter Hospital, Lookout Road, New Lambton Heights, N.S.W. 2305, Australia.
Warner
G
G
Bull
L
L
D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003907:Dexamethasone / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004452:Echocardiography; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007049:Iatrogenic Disease; D007223:Infant; D007231:Infant, Newborn; D007328:Insulin / Q000009:adverse effects*; D008297:Male
D005938:Glucocorticoids; D007004:Hypoglycemic Agents; D007328:Insulin; D003907:Dexamethasone