[Effect of administration of blood products on the course of tetanus antibody concentration in immuno-incompetent patients].
OBJECTIVE
Collecting of data for immunoprophylaxis of tetanus in immunodeficient patients via administration of blood products.


METHODS
Prospective single case studies.


METHODS
Clinical therapy in a department of hematology with continuous determination of tetanus antibody concentrations in patients' sera and administered blood products with an enzyme immunoassay.


METHODS
3 patients with acute myeloid leukemia (FAB classifications M1, M3, M4).


METHODS
Regular administration of blood products due to clinical therapy.


RESULTS
After administration of about 4,000 IU tetanus antitoxin i.v., serum concentration is increasing by 1 IU/ml. Half life in serum amounts to 7 days. Protection lasts therefore up to 6 weeks.


CONCLUSIONS
Immunodeficient patients may receive a medium-term effective protection against tetanus after selection of suitable blood products. This method is interesting also for prophylaxis of postoperative tetanus in immunocompetent patients.
Pietsch
M
M
Abteilung für Hygiene, Universität Mainz, Deutschland.
Töre
S
S
Schütt
K H
KH
D000907:Antibodies, Bacterial / Q000097:blood*; D016913:Blood Component Transfusion; D003017:Clostridium tetani / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000276:immunology* / Q000517:prevention & control; D011446:Prospective Studies; D013742:Tetanus / Q000276:immunology* / Q000517:prevention & control; D013743:Tetanus Antitoxin / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; D013743:Tetanus Antitoxin
Einfluss der Verabreichung von Blutprodukten auf den Verlauf der Tetanus-Antikörperkonzentration bei immuninkompetenten Patienten.