Immunization of pigs against Taenia solium cysticercosis: factors related to effective protection.
Fifty-six (56) pigs were immunized against Taenia solium cysticercosis with antigens from Taenia crassiceps metacestodes, in a variety of protocols, and then challenged orally with Taenia solium proglottids or eggs. Results of immunization (expressed as individual parasite loads) ranged from significant reduction of parasite loads (host protection) to clear increase (parasite facilitation) in apparent relation to the immunogen dose, adjuvant employed and genetic background of the pigs. In all trials, however, immunized pigs harboured more damaged cysticerci than controls, indicating that immunization does induce some restrictions to parasite these are eventually overwhelmed by other parasite-promoting factors. Western blots in immunized-protected pigs indicated antigens of 242, 234, 118, 77, 55 and 45 kDa as possibly being involved in immunological protection.
Sciutto
E
E
Instituto de Investigaciones Biomédicas, Mexico.
Aluja
A
A
Fragoso
G
G
Rodarte
L F
LF
Hernández
M
M
Villalobos
M N
MN
Padilla
A
A
Keilbach
N
N
Baca
M
M
Govezensky
T
T
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007114:Immunization / Q000662:veterinary*; D007115:Immunization Schedule; D051379:Mice; D008807:Mice, Inbred BALB C; D010270:Parasite Egg Count; D013552:Swine; D013553:Swine Diseases; D013621:Taenia / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth