title: Cytotoxicity and NMR spectral assignments of ergolide and bigelovin.
abstract: Two potent cytotoxic sesquiterpene lactones, ergolide (1) and bigelovin (2) were isolated from Inula hupehensis I. helianthus-aquatica and their structures and NMR data were assignment unambiguously by using a combination of one-and two-dimensional NMR techniques and computer modeling calculations.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Academia Sinica, People's Republic of China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: B N
authors.initials: BN
authors.lastname: Zhou
authors.forename: R W
authors.initials: RW
authors.lastname: Zhang
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lin
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lin
authors.forename: R R
authors.initials: RR
authors.lastname: Gil
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry* / Q000633:toxicity*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; C099797:ergolide; C099796:bigelovin