title: The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene.
abstract: The mouse homologue of the polycystic kidney disease 1 gene (PKD1) was mapped to chromosome 17 using somatic cell hybrids, B x D recombinant inbred strains, and FISH. The gene is located within a previously defined conserved synteny group that includes the mouse homologue of tuberous sclerosis 2 (TSC2) and is linked to the alpha globin pseudogene Hba-ps4. Although the human genome contains multiple copies of genes related to PKD1, there is no evidence for more than one copy in the mouse genome. Like their human counterparts, the mouse Tsc2 and Pkd1 genes are arranged in a tail-to-tail orientation with a distance of only 63 bp between the polyadenylation signals of the two genes.
authors.affiliation: Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom.
authors.forename: P G
authors.initials: PG
authors.lastname: Olsson
authors.forename: C
authors.initials: C
authors.lastname: Löhning
authors.forename: S
authors.initials: S
authors.lastname: Horsley
authors.forename: L
authors.initials: L
authors.lastname: Kearney
authors.forename: P C
authors.initials: PC
authors.lastname: Harris
authors.forename: A
authors.initials: A
authors.lastname: Frischauf
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008214:Lymphocytes; D051379:Mice; D008815:Mice, Inbred Strains; D007690:Polycystic Kidney Diseases / Q000235:genetics*; D011995:Recombination, Genetic; D015183:Restriction Mapping