title: Paclitaxel: current developmental approaches of the National Cancer Institute.
abstract: National Cancer Institute studies are addressing important issues in the development of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), including optimal dose and schedule, the development of combination chemotherapy and multimodality regimens, and the evaluation of paclitaxel-containing therapy as front-line and adjuvant treatment. Phase III trials are ongoing in ovary, breast, lung, and head and neck cancers. Broad phase II testing of paclitaxel is nearing completion. Recent identification of paclitaxel activity in esophageal, bladder, germ cell, and endometrial cancers and in Kaposi's sarcoma associated with the human immunodeficiency virus has provided additional areas for investigation. Promising results from initial trials provide reasons to expect further advances as investigators around the world continue to evaluate this important new drug.
authors.affiliation: Investigational Drug Branch, National Cancer Institute, Bethesda, MD, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Arbuck
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D016889:Endometrial Neoplasms / Q000188:drug therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005260:Female; D018237:Germinoma / Q000188:drug therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D009316:National Institutes of Health (U.S.); D010051:Ovarian Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D012514:Sarcoma, Kaposi / Q000188:drug therapy; D014481:United States; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel