Detection of the t(2;5)(p23;q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma.
In general, the large cell lymphomas are a cytogenetically heterogeneous group of diseases, and the cytogenetic findings do not correlate with morphological findings in this group of malignant lymphomas. The CD30-positive anaplastic large cell lymphomas, however, are thought to be an exception, with the t(2;5) reported to correlate with the morphological changes of this disease entity. A subgroup of Hodgkin's disease cases have been reported by some investigators to have the t(2;5) translocation, leading to speculation that these two diseases are related. In the current study, the authors used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) methodology to evaluate the frequency of t(2;5) in 33 cases of large cell lymphoma, of B lineage, other than anaplastic large cell lymphoma. The authors detected evidence of t(2;5) in four of the cases (12%), a frequency similar to that of the authors' previous study of cases of CD30 positive anaplastic large cell lymphoma. Three of the positive large B-cell lymphoma cases were CD30 negative and were morphologically indistinguishable from the cases without evidence of t(2;5). The fourth case had a subpopulation of CD30 positive cells but also did not have morphological features of anaplastic large cell lymphoma. These results would suggest that t(2;5) is not restricted to cases of malignant lymphomas with anaplastic morphology or to CD30 expression.
Arber
D A
DA
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Sun
L H
LH
Weiss
L M
LM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D014178:Translocation, Genetic