title: Evaluation of bone density with peripheral quantitative computed tomography in healthy premenopausal, perimenopausal, and postmenopausal women.
abstract: We compared bone mass in premenopausal, perimenopausal, and postmenopausal women using peripheral quantitative computed tomography to measure separately cortical, trabecular, and total bone density. Trabecular bone density was lower (p < 0.05) in the perimenopausal women than in the healthy premenopausal women. In perimenopausal women, trabecular bone density showed a significant linear regression with age (r = 0.554, p < 0.001), but cortical bone density did not (r = 0.130, p = 0.447). The group of postmenopausal women had significantly lower bone mass in all three bone compartments than the premenopausal and perimenopausal women. These findings confirm the existence of a significant loss of trabecular bone mass in the perimenopausal period.
authors.affiliation: Departamento de Medicina, Universidad de Alcalá de Henares, Madrid, Spain.
authors.forename: E R
authors.initials: ER
authors.lastname: Hernández
authors.forename: C
authors.initials: C
authors.lastname: Seco-Durban
authors.forename: M
authors.initials: M
authors.lastname: Revilla
authors.forename: J
authors.initials: J
authors.lastname: González-Riola
authors.forename: H
authors.initials: H
authors.lastname: Rico
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D017697:Premenopause / Q000502:physiology*; D014057:Tomography, X-Ray Computed