title: Univariate analysis of dichotomous or ordinal data from twin pairs: a simulation study comparing structural equation modeling and logistic regression.
abstract: The univariate analysis of categorical twin data can be performed using either structural equation modeling (SEM) or logistic regression. This paper presents a comparison between these two methods using a simulation study. Dichotomous and ordinal (three category) twin data are simulated under two different sample sizes (1,000 and 2,000 twin pairs) and according to different additive genetic and common environmental models of phenotypic variation. The two methods are found to be generally comparable in their ability to detect a "correct" model under the specifications of the simulation. Both methods lack power to detect the right model for dichotomous data when the additive genetic effect is low (between 10 and 20%) or medium (between 30 and 40%); the ordinal data simulations produce similar results except for the additive genetic model with medium or high heritability. Neither method could adequately detect a correct model that included a modest common environmental effect (20%) even when the additive genetic effect was large and the sample size included 2,000 twin pairs. The SEM method was found to have better power than logistic regression when there is a medium (30%) or high (50%) additive genetic effect and a modest common environmental effect. Conversely, logistic regression performed better than SEM in correctly detecting additive genetic effects with simulated ordinal data (for both 1,000 and 2,000 pairs) that did not contain modest common environmental effects; in this case the SEM method incorrectly detected a common environmental effect that was not present.
authors.affiliation: Division of Epidemiology-Biostatistics, University of Illinois-Chicago, School of Public Health, 60612, USA.
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
authors.forename: J M
authors.initials: JM
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Goldberg
authors.forename: W G
authors.initials: WG
authors.lastname: Henderson
mesh_terms: D000704:Analysis of Variance; D015982:Bias; D003627:Data Interpretation, Statistical; D004777:Environment; D014644:Genetic Variation; D006801:Humans; D016018:Least-Squares Analysis; D016015:Logistic Models; D008957:Models, Genetic; D010641:Phenotype; D015203:Reproducibility of Results; D018433:Twin Studies as Topic