[The immune homeostasis of patients with prostatic cancer on hormonal chemotherapy, radiation treatment and immunological action].
The trial covered 58 patients with prostatic cancer aged 50-79. Before treatment these patients exhibited weak proliferative response of T-cells to PHA, increased number of T-suppressors/killers, enhanced suppressive influence of regulatory cells. Hormone chemotherapy produced immunodepressive and immunomodulating effects (normalization of the count of T-suppressors/killers and their function). Subsequent radiotherapy on the prostatic region (total dose 60 Gy) worsened immunodepression. Efficacy of placental suspension and levamisol depends on the treatment stage at which the latter were used: during hormone chemotherapy the addition of the suspension and levamisol corrects its immunodepressive effects, in subsequent radiotherapy immunodeficiency greatly increased.
Panteleeva
E S
ES
Sviridova
T V
TV
Neprina
G S
GS
Sirotkina
N P
NP
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001782:Blood Donors; D001859:Bone Neoplasms / Q000556:secondary; D003131:Combined Modality Therapy; D006706:Homeostasis / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D007978:Levamisole / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010924:Placental Extracts / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000628:therapy*; D011879:Radiotherapy Dosage
D000276:Adjuvants, Immunologic; D006728:Hormones; D010924:Placental Extracts; D007978:Levamisole
Immunnyĭ gomeostaz bol'nykh rakom predstatel'noĭ zhelezy pri gormonokhimioterapii, luchevom lechenii i immunovozdeĭstvii.