[The effect of a low molecular weight synthetic humic substance on pre- and postnatal development in rats].
The influence of a low molecular synthetic humic substance (HS 1500) on pre- and postnatal development of rats was investigated. After oral application of 1000 mg/kg and 2000 mg/kg b. w. HS 1500 during the period of organogenesis (6th to 15th day p. c.) and from 16th day p. c. up to weaning neither adverse effects in the mothers nor in the fetuses were reported. The occurrence of a single malformation (gastroschisis) after application of 1000 mg/kg b. w. from day 6 to 15 of pregnancy, few ossifications of phalanges and differences in swimming behaviour are not regarded as the effect of the substance. In conclusion, the oral use of HS 1500 in the treatment of gastrointestinal diseases in animals during pregnancy is regarded to be riskless.
Lange
N
N
Institut für Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinischen Fakultät, Universität Leipzig.
Faqi
A S
AS
Kühnert
M
M
Haase
A
A
Höke
H
H
Seubert
B
B
D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006128:Growth / Q000187:drug effects*; D062385:Hydroxybenzoates / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D008970:Molecular Weight; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
C099097:HS 1500; D062385:Hydroxybenzoates
Untersuchungen zum Einfluss eines niedermolekularen synthetischen Huminstoffes auf die prä- und postnatale Entwicklung bei Ratten.