title: The relationship between anaesthetic uptake and cardiac output.
abstract: The hypothesis that anaesthetic uptake during maintenance of anaesthesia is related to cardiac output was tested on 21 patients undergoing cardiac surgery. Using a computer-controlled closed breathing system, enflurane was administered to maintain an end-expired concentration of 1%. Cardiac output was measured by thermodilution using a pulmonary artery catheter. A clear qualitative but not quantitative relationship was demonstrated. Changes in anaesthetic requirements at a constant end-expired concentration are a better guide to changes in cardiac output than changes in end-expired carbon dioxide with constant ventilation in patients undergoing cardiac surgery.
authors.affiliation: Department of Anaesthetics, Hemel Hempstead General Hospital, Herts.
authors.forename: S J
authors.initials: SJ
authors.lastname: Watt
authors.forename: L B
authors.initials: LB
authors.lastname: Cook
authors.forename: S
authors.initials: S
authors.lastname: Ohri
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D002302:Cardiac Output / Q000502:physiology*; D001026:Coronary Artery Bypass; D004737:Enflurane / Q000493:pharmacokinetics*; D006801:Humans
chemical_list: D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D004737:Enflurane