title: Long-term sequelae of hearing impairment in congenital hypothyroidism.
abstract: Hearing loss and its functional consequences were evaluated retrospectively in children with congenital hypothyroidism. From a cohort of 101 children followed longitudinally to evaluate newborn screening, 75 with previous hearing tests were studied. Fifteen (20%) were found to have hearing problems. Of these, nine had unilateral or sensorineural loss mostly at high frequencies, five had a conductive loss, and one had both problems. Hearing impaired children differed from children with normal hearing in age of treatment onset (22 vs 14 days) but not disease severity or duration. A comparison of language and auditory processing skills at ages 3, 5, and 7 years revealed that early speech was delayed in hearing impaired children, whereas deficits persisted in later receptive language and auditory discrimination skills. Comparing hearing impaired children and children with normal hearing with matched control subjects at grade 3 showed that hearing impaired children were poorer readers because of less adequate phonologic processing skills.
authors.affiliation: Department of Psychology and Communication Disorders, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Rovet
authors.forename: W
authors.initials: W
authors.lastname: Walker
authors.forename: B
authors.initials: B
authors.lastname: Bliss
authors.forename: L
authors.initials: L
authors.lastname: Buchanan
authors.forename: R
authors.initials: R
authors.lastname: Ehrlich
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003409:Congenital Hypothyroidism; D005260:Female; D005500:Follow-Up Studies; D006311:Hearing Disorders / Q000151:congenital* / Q000175:diagnosis / Q000517:prevention & control; D006314:Hearing Loss, Conductive / Q000151:congenital / Q000175:diagnosis / Q000517:prevention & control; D006316:Hearing Loss, High-Frequency / Q000151:congenital / Q000175:diagnosis / Q000517:prevention & control; D006319:Hearing Loss, Sensorineural / Q000151:congenital / Q000175:diagnosis / Q000517:prevention & control; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000517:prevention & control; D007223:Infant; D007231:Infant, Newborn; D007805:Language Development Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D008137:Longitudinal Studies; D008297:Male; D015997:Neonatal Screening; D009864:Ontario / Q000453:epidemiology; D011932:Reading; D012189:Retrospective Studies