title: On the structure of replication and transcription factories.
abstract: Recent experiments suggest that active polymerases are concentrated in large structures, 'factories', within eukaryotic nuclei. Data concerning the structure of these factories is reviewed.
authors.affiliation: CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: T A
authors.initials: TA
authors.lastname: Hughes
authors.forename: A
authors.initials: A
authors.lastname: Pombo
authors.forename: J
authors.initials: J
authors.lastname: McManus
authors.forename: P
authors.initials: P
authors.lastname: Hozák
authors.forename: D A
authors.initials: DA
authors.lastname: Jackson
authors.forename: P R
authors.initials: PR
authors.lastname: Cook
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology / Q000648:ultrastructure*; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000032:analysis; D012321:DNA-Directed RNA Polymerases / Q000032:analysis; D006801:Humans; D008957:Models, Genetic; D014158:Transcription, Genetic
chemical_list: D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase