[The L-arginine/nitric oxide metabolic pathway. Its physiopathology and clinical implications].
The L-arginine/nitric oxide (NO) pathway plays a key role in a number of biological processes within most organs and systems. Increasing attention has been addressed to its involvement in the pathogenesis of various human diseases. In this review we examine the enzymology of different NO-synthase isoforms, the major NO detection techniques as well as the possible clinical and pharmacological implications of this new metabolic pathway.
Mengozzi
G
G
Dipartimento di Medicina e Oncologia Sperimentale, Università degli Studi di Torino.
Veglio
F
F
Schiavone
D
D
Inconis
T
T
Mulatero
P
P
Paradisi
L
L
D001120:Arginine / Q000378:metabolism*; D002319:Cardiovascular System / Q000503:physiopathology; D004064:Digestive System / Q000503:physiopathology; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D009420:Nervous System / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D012137:Respiratory System / Q000503:physiopathology; D014551:Urinary Tract / Q000503:physiopathology
D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase
La via metabolica L-arginina/ossido di azoto. Fisiopatologia ed implicazioni cliniche.