Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.
Mulder
G J
GJ
Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.
D000477:Alkylating Agents / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D019008:Drug Resistance, Neoplasm; D005818:Genetic Engineering; D005982:Glutathione Transferase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008466:Mechlorethamine / Q000378:metabolism / Q000494:pharmacology*; D016296:Mutagenesis / Q000187:drug effects / Q000235:genetics
D000477:Alkylating Agents; D008466:Mechlorethamine; D005982:Glutathione Transferase