Cerebrospinal fluid soluble L-selectin (sCD62L) in meningoencephalitis.
The leucocyte adhesion molecule L-selectin (CD62L) is rapidly cleaved off proteolytically after cell activation, generating soluble L-selectin (sCD62L) molecules. sCD62L concentrations were determined in 185 cerebrospinal fluid (CSF) samples obtained from children aged 1 month to 17 years. In 36 CSF samples of children with meningoencephalitis, sCD62L was significantly higher (median 209 fmol/ml) than in samples of children with other febrile diseases (n = 67, median 50 fmol/ml) or non-febrile disorders (n = 82, median 44 fmol/ml). There was a positive correlation between CSF protein and CSF sCD62L (rS = 0.68), suggesting that a disturbed blood-brain barrier contributes to raised sCD62L concentrations in the CSF. However, the CSF sCD62L/protein ratio of children with meningoencephalitis was significantly higher than in children with other febrile diseases or non-febrile disorders, indicating that sCD62L concentrations in children with meningoencephalitis were higher than expected from plasma leakage alone. It is concluded that both an impaired blood-brain barrier and the generation of sCD62L by infiltrating leucocytes contribute to raised CSF sCD62L concentrations in children with meningoencephalitis.
Bührer
C
C
Department of Neonatology, Children's Hospital, Humboldt University, Berlin, Germany.
Herold
R
R
Stibenz
D
D
Henze
G
G
Obladen
M
M
D000208:Acute Disease; D000293:Adolescent; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005334:Fever / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D019041:L-Selectin / Q000134:cerebrospinal fluid*; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid*; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012995:Solubility
D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D019041:L-Selectin