Gastric carcinoma in siblings with Friedreich's ataxia.
Friedreich's ataxia is a hereditary neurological condition characterized by severe ataxia. We report the cases of two siblings with this condition, both of whom developed signet ring cell adenocarcinoma of the stomach at a young age. This association has not been previously described and it suggests the presence of an unidentified aberrant gene.
Ackroyd
R
R
Department of Surgery, Royal Hallamshire Hospital, Sheffield, UK.
Shorthouse
A J
AJ
Stephenson
T J
TJ
D000328:Adult; D018279:Carcinoma, Signet Ring Cell / Q000150:complications* / Q000473:pathology; D005260:Female; D005621:Friedreich Ataxia / Q000150:complications* / Q000235:genetics; D006801:Humans; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology