title: Inhibitors of dihydro-orotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs.
authors.affiliation: Department of Biochemistry, University of Sydney, NSW, Australia.
authors.forename: R I
authors.initials: RI
authors.lastname: Christopherson
authors.forename: N K
authors.initials: NK
authors.lastname: Williams
authors.forename: S L
authors.initials: SL
authors.lastname: Schoettle
authors.forename: E
authors.initials: E
authors.lastname: Szabados
authors.forename: T W
authors.initials: TW
authors.lastname: Hambley
authors.forename: M K
authors.initials: MK
authors.lastname: Manthey
mesh_terms: D000495:Allosteric Site; D000582:Amidophosphoribosyltransferase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002256:Carbonic Anhydrases / Q000235:genetics; D006224:Cricetinae; D004080:Dihydroorotase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005492:Folic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D005493:Folic Acid Antagonists / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D009709:Nucleotide Deaminases / Q000037:antagonists & inhibitors*; D017354:Point Mutation; D017386:Sequence Homology, Amino Acid
chemical_list: D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; C010920:dihydrofolate; D005492:Folic Acid; D000582:Amidophosphoribosyltransferase; D004080:Dihydroorotase; D009709:Nucleotide Deaminases; C021436:IMP cyclohydrolase; D002256:Carbonic Anhydrases