title: Conservation treatment in subareolar breast cancers.
abstract: The results of centromammary conservation in 37 patients with 20 mm-median-size breast cancer, located in the subareolar area (SAA), with an infiltration of the nipple-areolar-complex (NAC) in 12 patients and a retraction in 24, are reported. Breast conservative surgery was initially performed in 30 patients; five patients were first treated with chemotherapy; two patients received initial tamoxifen. Surgery comprised tumorectomy plus axillary dissection, with complete resection of the NAC (20 patients), or partial resection (nine patients), or without resection (eight patients). Post-operatively, all patients received 50 Gy external radiotherapy, with an additional external electron boost in 13 patients; 14 patients received adjuvant tamoxifen and two patients adjuvant chemotherapy. With a median follow-up of 49 months, one patient experienced a local failure and four a metastatic failure; 5-year overall actuarial survival and disease-free survival rates were 97%, and 75%. Cosmetic results were excellent in three patients, good in 25, and poor in seven. Breast conservation appears a satisfying treatment in small breast cancer located in SAA.
authors.affiliation: Department of Surgical Oncology, Institut Bergonié, Regional Cancer Center, Bordeaux, France.
authors.forename: E
authors.initials: E
authors.lastname: Bussières
authors.forename: F
authors.initials: F
authors.lastname: Guyon
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: E
authors.initials: E
authors.lastname: Stöckle
authors.forename: A
authors.initials: A
authors.lastname: Faucher
authors.forename: M
authors.initials: M
authors.lastname: Durand
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004954:Esthetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009558:Nipples; D012189:Retrospective Studies; D015996:Survival Rate; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D013629:Tamoxifen