The correlation between neuropsychological and neuroanatomic changes over time in asymptomatic and symptomatic HIV-1-infected individuals.
To determine the relationship between neuroanatomic and neuropsychological changes in both asymptomatic and symptomatic HIV-1-infected individuals, we conducted a longitudinal study of 47 HIV-infected individuals, 15 of whom were asymptomatic and 32 of whom had either AIDS-related complex or AIDS. To measure neuroanatomic change over a 30-month period, we conducted quantitative MRI measures of bicaudate/brain ratio (BCR) and bifrontal/ brain ratio. A comparison of change over time between BCR and neuropsychological performance showed a correlation between increase in atrophy and worsening in certain cognitive functions. The correlation held for both asymptomatic and symptomatic groups, with more pronounced changes in the symptomatic group.
Hall
M
M
AIDS Neurologic Center, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Whaley
R
R
Robertson
K
K
Hamby
S
S
Wilkins
J
J
Hall
C
C
D015526:AIDS Dementia Complex / Q000473:pathology* / Q000523:psychology*; D000386:AIDS-Related Complex / Q000473:pathology / Q000523:psychology; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology / Q000523:psychology; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D015658:HIV Infections / Q000473:pathology* / Q000523:psychology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D016037:Single-Blind Method