title: DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families.
abstract: Although the human leukocyte antigen DR2/DQw1 allele has been associated with multiple sclerosis, studies of DR2/DQw1 inheritance in multiple sclerosis multiplex families have yielded conflicting results. We examined this question in "high-incidence" families, defined as families with more than 50% of siblings affected. DR2/DQw1 allele frequencies were significantly increased, particularly in mothers and affected siblings (p < 0.0001). The transmission of DR2/DQw1 from both parents was more frequent in affected offspring (p = 0.005). While evidence for segregation of disease with a particular parental allele was lacking in most families, the frequency of haplotype sharing was higher in affected sib pairs (p < 0.01).
authors.affiliation: Neuroimmunology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Voskuhl
authors.forename: A M
authors.initials: AM
authors.lastname: Goldstein
authors.forename: T
authors.initials: T
authors.lastname: Simonis
authors.forename: R J
authors.initials: RJ
authors.lastname: Davey
authors.forename: H F
authors.initials: HF
authors.lastname: McFarland
mesh_terms: D000483:Alleles; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D010375:Pedigree
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens