Relevance of plasma protein binding to antiviral activity and clinical efficacy of inhibitors of human immunodeficiency virus protease.
Bilello
J A
JA
Drusano
G L
GL
D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism*; D002219:Carbamates; D002986:Clinical Trials as Topic; D005663:Furans; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009961:Orosomucoid / Q000378:metabolism; D011485:Protein Binding; D013449:Sulfonamides / Q000378:metabolism / Q000494:pharmacology*
D000998:Antiviral Agents; D001798:Blood Proteins; D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D009961:Orosomucoid; D013449:Sulfonamides; C095108:amprenavir