title: [Papillomatosis confluens et reticularis. Successful therapy with minocycline].
abstract: Confluent and reticulated papillomatosis (CRP) is a rare dermatosis of unknown aetiology. Recent electron microscopic studies suggest that CRP is a disorder of keratinisation. In our case we could not confirm the previously reported ultrastructural findings. CRP is generally resistant to therapy. We treated a 19-year-old patient with typical CRP with oral minocycline. Within a few weeks the eruption resolved completely. A mild relapse 7 months later responded promptly to a repeated course of minocycline. Twelve months after discontinuation of therapy there is no evidence of recurrence. In CRP minocycline should be preferred to systemic retinoid therapy because of its minor side effects.
authors.affiliation: Universitäts-Hautklinik, Münster.
authors.forename: L
authors.initials: L
authors.lastname: Kretzschmar
authors.forename: D
authors.initials: D
authors.lastname: Metze
authors.forename: K H
authors.initials: KH
authors.lastname: Vehring
authors.forename: G
authors.initials: G
authors.lastname: Bonsmann
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008911:Minocycline / Q000008:administration & dosage*; D010212:Papilloma / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline
vernacular_title: Papillomatosis confluens et reticularis. Erfolgreiche Therapie mit Minocyclin.