Synthesis and antitumor activity of some analogues of flavone acetic acid.
Some coumarin-, flavonol- and flavanon-acetic acids are described. The cytotoxicity of the synthesized compounds was determined on a human colon carcinoma cell line (LoVo) through evaluation of neutral red uptake, performed by the Riddel method. All tested derivatives were able to induce a statistically significant reduction of lysosomal neutral red uptake at 5 x 10(-5) M concentration. Some compounds were more active than the reference compound flavon-8-acetic acid.
Valenti
P
P
Department of Pharmaceutical Sciences, University of Bologna, Italy.
Fabbri
G
G
Rampa
A
A
Bisi
A
A
Gobbi
S
S
Da Re
P
P
Carrara
M
M
Sgevano
A
A
Cima
L
L
D000085:Acetates / Q000138:chemical synthesis* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003374:Coumarins / Q000138:chemical synthesis / Q000627:therapeutic use; D005419:Flavonoids / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000085:Acetates; D000970:Antineoplastic Agents; D003374:Coumarins; D005419:Flavonoids