The role of BSAP (Pax-5) in B-cell development.
The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
Busslinger
M
M
Research Institute of Molecular Pathology, Vienna, Austria.
Urbánek
P
P
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics; D018941:Antigens, CD19 / Q000096:biosynthesis / Q000235:genetics; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D001483:Base Sequence; D001665:Binding Sites; D002454:Cell Differentiation; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000378:metabolism*; D015870:Gene Expression; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000378:metabolism*; D051757:PAX5 Transcription Factor; D011961:Receptors, Fc / Q000096:biosynthesis / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D015703:Antigens, CD; D018941:Antigens, CD19; D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; C497282:Pax5 protein, mouse; D011961:Receptors, Fc; D014157:Transcription Factors; C035311:immunoglobulin M receptor