The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA.
The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements.
Lundwall
A
A
Department of Clinical Chemistry, Lund University, University Hospital, Malmö, Sweden.
D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA; D012739:Gonadal Steroid Hormones / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D012091:Repetitive Sequences, Nucleic Acid; D029607:Seminal Vesicle Secretory Proteins; D012689:Sequence Homology, Nucleic Acid
D012739:Gonadal Steroid Hormones; D029607:Seminal Vesicle Secretory Proteins; C424482:seminal vesicle-specific antigen; D004247:DNA