Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells responded by expressing several activation markers and by growing, In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA+ gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.
Lundgren
E
E
Department of Cell and Molecular Biology, University of Umeå, Sweden.
Carballeira
N
N
Vazquez
R
R
Dubinina
E
E
Bränden
H
H
Persson
H
H
Wolf-Watz
H
H
D018829:Adhesins, Bacterial; D001402:B-Lymphocytes / Q000276:immunology*; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000502:physiology*; D006801:Humans; D019012:Integrin beta1 / Q000502:physiology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology; D015011:Yersinia pseudotuberculosis / Q000276:immunology*
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D019012:Integrin beta1; C053476:invasin, Yersinia