title: Abnormal behavior and neurotransmissions of tenascin gene knockout mouse.
abstract: To examine the role of tenascin (TN) in vivo, we have produced mice in which the TN gene is inactivated. In behavioral studies, TN-knockout mice showed abnormal behavior such as hyperlocomotion and poor swimming ability. Biochemical analysis revealed that serotonin (5-HT) and dopamine (DA) transmission was decreased in the cerebral cortex, the hippocampus, or the striatum of TN-knockout mouse brain. The intraperitoneal administration of the DA receptor agonist, LY171555 (0.5 mg/kg, BW), inhibited the hyperlocomotion, and swimming behavior was transiently improved by the treatment with the 5-HT receptor agonist, 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride. These findings suggest that TN may play an important role in neurotransmissions related to behavior.
authors.affiliation: Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Fukamauchi
authors.forename: N
authors.initials: N
authors.lastname: Mataga
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Youshiki
authors.forename: M
authors.initials: M
authors.lastname: Kusakabe
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015259:Dopamine Agents / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011869:Radioligand Assay; D018490:Serotonin Agents / Q000378:metabolism / Q000494:pharmacology; D019063:Tenascin / Q000235:genetics*
chemical_list: D015259:Dopamine Agents; D018377:Neurotransmitter Agents; D018490:Serotonin Agents; D019063:Tenascin