Significance of urinary tissue polypeptide specific antigen (TPS) determination in patients with urothelial carcinoma.
Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (UTPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.
Yao
W J
WJ
Department of Nuclear Medicine, National Cheng Kung University Hospital Tainan, Taiwan, Republic of China.
Chang
C J
CJ
Chan
S H
SH
Chow
N H
NH
Cheng
H L
HL
Tzai
T S
TS
Lin
S N
SN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000652:urine*; D014408:Biomarkers, Tumor / Q000652:urine*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000401:mortality / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000652:urine; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000652:urine; D010455:Peptides / Q000652:urine*; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D014570:Urologic Diseases / Q000652:urine; D014571:Urologic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000652:urine*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D010455:Peptides; C089984:tissue polypeptide specific antigen