title: Patients with Turner's syndrome may have an inherent endometrial abnormality affecting receptivity in oocyte donation.
abstract: OBJECTIVE
  To evaluate whether endometrial receptivity is compromised in patients with premature ovarian failure (POF) due to Turner's syndrome who undergo oocyte donation.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  In vitro fertilization-ET units, anonymous oocyte donation program.
  
  
  METHODS
  The study included 53 patients with POF who underwent oocyte donation. These included 7 patients with Turner's syndrome (45,X) who underwent 22 ET cycles, 15 women with Turner variants (mosaics, deletions, or isochromosomes) who underwent 36 ET cycles, and 31 other patients with POF and a normal karyotype who underwent 69 oocyte donation cycles.
  
  
  METHODS
  All patients on standby for donation were treated with E2 valerate 6 mg/d until oocytes became available; then P 100 mg/d was added. Oocyte donors were healthy women < 34 years who underwent IVF themselves.
  
  
  METHODS
  Clinical pregnancy rates (PRs), biochemical pregnancies, early abortions, and delivery rates were evaluated.
  
  
  RESULTS
  Turner's syndrome patients had a significantly higher rate of biochemical pregnancies (22.7% versus 4.3%), a lower clinical PR (22.7% versus 33.3%), a significantly higher rate of early abortions (60% versus 8.7%), and a significantly lower rate of deliveries per pregnancy (20.0% versus 73.1%) compared with non-Turner patients.
  
  
  CONCLUSIONS
  Patients with a complete or partial deficiency of an X chromosome have reduced PRs and an increase in early implantation failure after oocyte donation. This may indicate an inherent endometrial abnormality, possibly associated with a deficiency of X-linked genes regulating endometrial receptivity.
authors.affiliation: Serlin Maternity Hospital, Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Yaron
authors.forename: Y
authors.initials: Y
authors.lastname: Ochshorn
authors.forename: A
authors.initials: A
authors.lastname: Amit
authors.forename: I
authors.initials: I
authors.lastname: Yovel
authors.forename: A
authors.initials: A
authors.lastname: Kogosowki
authors.forename: J B
authors.initials: JB
authors.lastname: Lessing
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004624:Embryo Transfer; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D018587:Oocyte Donation; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000503:physiopathology*; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics; D014960:X Chromosome
chemical_list: D004958:Estradiol