Drug-induced transient myopia and angle-closure glaucoma associated with supraciliary choroidal effusion.
OBJECTIVE
We investigated the mechanism of drug-induced transient myopia, anterior chamber shallowing, and secondary angle-closure glaucoma in a young woman.


METHODS
Ultrasound biomicroscopy was performed and the effects of cycloplegic eyedrops and unilateral laser iridotomy were evaluated.


RESULTS
Cycloplegic eyedrops and unilateral laser iridotomy had no effect. Ultrasound biomicroscopy identified the presence of a supraciliary choroidal effusion that caused forward displacement of the lens-iris diaphragm, resulting in increased myopia, anterior chamber shallowing, and angle-closure glaucoma. Discontinuance of trimethoprim and sulfamethoxazole combination led to the complete resolution of the condition.


CONCLUSIONS
Idiosyncratic drug reactions may produce a supraciliary choroidal effusion, resulting in myopia and secondary angle-closure glaucoma from the induced forward shift in the position of the crystalline lens and ciliary body.
Postel
E A
EA
Duke University Eye Center, Durham, NC 27710, USA.
Assalian
A
A
Epstein
D L
DL
D000328:Adult; D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000473:pathology; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002829:Choroid / Q000098:blood supply; D015862:Choroid Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002924:Ciliary Body / Q000098:blood supply; D005122:Exudates and Transudates; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000503:physiopathology; D006068:Gonioscopy; D006801:Humans; D007498:Iris / Q000000981:diagnostic imaging / Q000601:surgery; D053685:Laser Therapy; D009216:Myopia / Q000139:chemically induced* / Q000503:physiopathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use; D014463:Ultrasonography; D014603:Uveal Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination