title: Resection margins of 2 versus 5 cm for cutaneous malignant melanoma with a tumor thickness of 0.8 to 2.0 mm: randomized study by the Swedish Melanoma Study Group.
abstract: BACKGROUND
  The traditional surgical treatment for primary malignant melanoma has often been a wide excision with a margin of about 5 cm. Since the risk of local recurrences is dependent on tumor thickness, thin tumors (<1 mm) have routinely been excised with a narrow margin. For thick tumors, the optimal resection margin is controversial, and can be determined only by prospective, randomized trials.
  
  
  METHODS
  The Swedish Melanoma Study Group performed a prospective, randomized multicenter study to evaluate an excision margin of 2 versus 5 cm for patients with cutaneous malignant melanoma with tumor thickness > 0.8 and < or = 2.0 mm. The trial includes 769 patients. Patients with melanomas of the skin of the head, neck, hands, feet, or vulva were not included in the trial. In the event of an excision biopsy for diagnosis, radical surgery was completed within 6 weeks. The median follow-up time was 5.8 years for estimation of survival and 4.0 years for diagnosis of recurrent disease.
  
  
  RESULTS
  No significant differences have been observed between the treatment groups regarding local or regional recurrences or survival.
  
  
  CONCLUSIONS
  We recommend an excision with a margin of 2 cm for cutaneous malignant melanoma with a tumor thickness > 0.8 and < or = 2.0 mm.
authors.affiliation: Department of Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Ringborg
authors.forename: R
authors.initials: R
authors.lastname: Andersson
authors.forename: J
authors.initials: J
authors.lastname: Eldh
authors.forename: B
authors.initials: B
authors.lastname: Glaumann
authors.forename: L
authors.initials: L
authors.lastname: Hafström
authors.forename: S
authors.initials: S
authors.lastname: Jacobsson
authors.forename: P E
authors.initials: PE
authors.lastname: Jönsson
authors.forename: H
authors.initials: H
authors.lastname: Johansson
authors.forename: L
authors.initials: L
authors.lastname: Krysander
authors.forename: B
authors.initials: B
authors.lastname: Lagerlöf
mesh_terms: D001706:Biopsy; D062109:Dermatologic Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011446:Prospective Studies; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D013548:Sweden