Regulatory features of multicatalytic and 26S proteases.
It should be clear from the foregoing accounts that our understanding of MCP and 26S regulation is still rudimentary. Moreover, we have only recently identified about a dozen natural substrates of these two proteases. Those outside the field may view the situation with some dismay. Those who study the MCP and 26S enzymes are provided with rich opportunities to address fundamental questions of protein catabolism and metabolic regulation.
Hoffman
L
L
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City 84132, USA.
Rechsteiner
M
M
D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001105:Archaea / Q000201:enzymology; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D005057:Eukaryotic Cells / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009363:Neoplasm Proteins / Q000502:physiology; D010447:Peptide Hydrolases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000502:physiology; D051381:Rats; D013312:Stress, Physiological / Q000201:enzymology; D013347:Subcellular Fractions / Q000201:enzymology; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured; D014452:Ubiquitins / Q000378:metabolism
D009097:Multienzyme Complexes; D009363:Neoplasm Proteins; D011506:Proteins; D014452:Ubiquitins; C088683:multicatalytic protease activator; D000255:Adenosine Triphosphate; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease