Measurement of nasal mucociliary transport rates on the isolated human inferior turbinate.
The mucociliary transport rate was measured using sequential images of graphite particles moving on 17 isolated human inferior turbinates. These had been removed from 13 patients who had normal saccharin clearance tests on the day of surgery. The initial mean mucociliary transport rate was found to be 4.1 mm/min rising to 5.0 mm/min 2 h after harvesting. After 4 h it fell to 3.7 mm/min. Where the rate was measured at two different sites on the same turbinate (n = 4), there was a close correlation over 6 h (r = 0.95, P < 0.001). When the turbinates were exposed to an aqueous solution of adrenaline (1:10,000) or a 2.5% cocaine solution, the rate increased or decreased respectively by 100% and 58% but returned to within 10% of the initial level within 2 h. We believe that the isolated inferior turbinate can be considered a useful model for the study of mucociliary clearance and agents that may influence it.
Mason
J D
JD
Department of Otorhinolaryngology, Nottingham University, UK.
Aspden
T J
TJ
Adler
J
J
Jones
N S
NS
Illum
L
L
Davis
S S
SS
D003042:Cocaine / Q000493:pharmacokinetics*; D046508:Culture Techniques; D004837:Epinephrine / Q000493:pharmacokinetics*; D006801:Humans; D009079:Mucociliary Clearance; D013997:Time Factors; D014420:Turbinates / Q000378:metabolism*
D003042:Cocaine; D004837:Epinephrine