CD-44 is not involved in the metastatic spread of ovarian cancer in vivo.
It has been shown that isoforms of the adhesion molecule CD44 are involved in the metastatic spread of several human malignancies. To determine whether CD44 plays a role in metastasis of human ovarian cancer, the tumours and corresponding metastases of 28 patients were investigated. CD44 was detected by immunohistochemistry in 2 primary tumours (7.1%) and 3 metastases (10.7%). In no case did both the primary tumour and metastasis show CD44 expression simultaneously. The results presented here suggest that CD44 does not play a crucial role in the metastatic spread of human ovarian cancer.
Speiser
P
P
University Hospital Vienna, Medical School, Department of Obstetrics and Gynecology, Vienna, Austria.
Wanner
C
C
Breitenecker
G
G
Kohlberger
P
P
Kainz
C
C
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology*; D012326:RNA Splicing
D000951:Antigens, Neoplasm; D018960:Hyaluronan Receptors