title: Primary cardiac lymphoma. No evidence for an etiologic association with Epstein-Barr virus.
abstract: OBJECTIVE
  To report two cases of primary cardiac lymphoma, a rare extranodal lymphoma with an unknown pathogenesis, and to compare them to secondary B-cell cardiac lymphoma.
  
  
  METHODS
  Clinicopathologic features are described, using histologic and immunophenotypic examinations. The Epstein-Barr virus genome is detected by in situ hybridization.
  
  
  METHODS
  Of 80 autopsied cases of malignant lymphoma identified at Nagoya (Japan) University Hospital, two patients with primary cardiac lymphoma and five patients with secondary cardiac B-cell lymphoma were selected.
  
  
  RESULTS
  None of the seven selected cases showed immunodeficiency, autoimmune disorders, or chronic inflammatory processes. Primary cardiac lymphomas had B-cell phenotypes with mu and lambda chain monoclonality. Immunostaining for Epstein-Barr virus (latent membrane protein-1) and Epstein-Barr virus-encoded RNA-1 in situ hybridization did not demonstrate an association of these lymphoma with Epstein-Barr virus infection. The majority of secondary cardiac B-cell lymphomas were extranodal lymphomas and extranodal or serosal involvement was more prominent than nodal involvement.
  
  
  CONCLUSIONS
  These findings suggest that primary cardiac lymphoma, unlike pyothorax-associated pleural lymphoma, appears to have no association with chronic inflammation or Epstein-Barr virus infection.
authors.affiliation: Department of Pathology, Nagoya University Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: T
authors.initials: T
authors.lastname: Yokoi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: J
authors.initials: J
authors.lastname: Asai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D006338:Heart Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*; D006352:Heart Ventricles / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D008223:Lymphoma / Q000276:immunology / Q000473:pathology / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers