title: In-line filtration of platelet concentrates obtained with the Omnix blood cell separator.
abstract: The quality of platelet concentrates (PC) obtained with the blood cell separator Omnix was investigated before and after in-line filtration. PC were filtered 2h (protocol A) and 4 h (protocol B) after the termination of apheresis. Platelet (PLT) yield after filtration was similar in both protocols (median 3.7 vs. 3.4 x 10(11)). Median white blood cell (WBC) contamination after leucocyte depletion was 0.07 x 10(6) (range 0.02-3.27 x 10(6)) in protocol A and 0.06 x 10(6) (range 0.02-2.1 x 10(6)) in protocol B. Glucose, lactate, lactate dehydrogenase, morphology score and pH value were not statistically different before and after filtration in both protocols. We conclude that in-line filtration results in sufficient leucocyte depletion of the PC. The prefiltration storage time did not influence the studied parameters of product quality.
authors.affiliation: Institute for Transfusion Medicine, University Clinics, Essen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Moog
authors.forename: N
authors.initials: N
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Nieper
mesh_terms: D001773:Blood Cells / Q000166:cytology*; D001782:Blood Donors; D002469:Cell Separation / Q000295:instrumentation*; D005374:Filtration / Q000379:methods*; D006801:Humans; D010983:Plateletpheresis; D012016:Reference Values