title: Alteration of c-fos gene methylation in human gliomas.
abstract: In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.
authors.affiliation: Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uyeno
authors.forename: J
authors.initials: J
authors.lastname: Komura
authors.forename: R
authors.initials: R
authors.lastname: Tawa
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Nata
authors.forename: H
authors.initials: H
authors.lastname: Sasano
authors.forename: H
authors.initials: H
authors.lastname: Nakura
authors.forename: K
authors.initials: K
authors.lastname: Sagisaka
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: T
authors.initials: T
authors.lastname: Kayama
authors.forename: T
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: T
authors.initials: T
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003596:Cytosine / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D005091:Exons; D005260:Female; D016762:Genes, fos; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007438:Introns; D008297:Male; D008745:Methylation; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D004273:DNA, Neoplasm; D012333:RNA, Messenger; D003596:Cytosine