Antimutagenic effects of polyphenols isolated from Terminalia bellerica myroblan in Salmonella typhimurium.
Antimutagenic effect of 2 polyphenolic fractions isolated from T. bellerica in TA98 and TA100 strains of S. typhimurium against 2AF, NPD and 4NQNO has been characterized. Both the fractions were significantly effective against S9-dependent 2AF; less effective against NPD and almost not effective against 4NQNO in TA100 strain. Using 13C-NMR spectral analysis, the TB-3 fraction, which was significantly more effective against 2AF compared to TB-4, was found to be a mixture of 3 tannins while TB-4 was non-tannin fraction. Interaction of polyphenols with S9 proteins may be the probable cause of inhibitory effect of these polyphenols, though the possibility of other mechanisms cannot be ruled out.
Padam
S K
SK
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India.
Grover
I S
IS
Singh
M
M
D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids; D005638:Fruit / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D012486:Salmonella typhimurium / Q000187:drug effects*; D013045:Species Specificity
D016587:Antimutagenic Agents; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols