title: Effects of a vigilance-enhancing drug, modafinil, on rat brain metabolism: a 2D COSY 1H-NMR study.
abstract: The effects of modafinil, a vigilance-enhancing drug, on brain metabolism were investigated directly in situ by the 2D COSY 1H-NMR spectroscopy in anesthetized rats. Modafinil (600 mg/kg, i.p.) induced significant increases in both aspartate (72% +/- 15%) and glutamate-glutamine pool (28% +/- 8%) simultaneously with increases in inositol (51% +/- 19%) and creatine-phosphocreatine pool (47% +/- 14%) in comparison with control values (P < 0.05; n = 5). These results suggest that the awakening properties of modafinil could be mediated by metabolic activation.
authors.affiliation: Dept. de Physiologie Systémique, Institut de Médecine Aérospatiale (IMASSA-CERMA), Bretigny Sur Orge, France.
authors.forename: C
authors.initials: C
authors.lastname: Piérard
authors.forename: P
authors.initials: P
authors.lastname: Satabin
authors.forename: D
authors.initials: D
authors.lastname: Lagarde
authors.forename: B
authors.initials: B
authors.lastname: Barrère
authors.forename: C Y
authors.initials: CY
authors.lastname: Guezennec
authors.forename: J P
authors.initials: JP
authors.lastname: Menu
authors.forename: M
authors.initials: M
authors.lastname: Pérès
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D003401:Creatine / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D000077408:Modafinil; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D010725:Phosphocreatine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; D003401:Creatine; D000077408:Modafinil