Transperineal photodynamic ablation of the canine prostate.
OBJECTIVE
Experiments were undertaken to determine the effects of transperineal interstitial photodynamic therapy on the canine prostate.


METHODS
Mongrel dogs were injected intravenously with the photosensitizer, tin (II) ethyl etiopurpurin dichloride. Twenty-four hours later, 2 optical fibers were implanted in 1 hemisphere of the prostate, which was then treated with red light (660 nm.).


RESULTS
Acutely, the treated areas showed extensive hemorrhagic necrosis. At 3 and 6 weeks, the treated lobes were largely replaced by fibrous connective tissue.


CONCLUSIONS
Transperineal photodynamic therapy of the canine prostate is feasible. Further preclinical investigation is warranted to determine the applicability of this approach to the treatment of localized prostate cancer.
Selman
S H
SH
Department of Urology, Medical College of Ohio, Toledo 43699-0008, USA.
Keck
R W
RW
Hampton
J A
JA
D000818:Animals; D004285:Dogs; D008297:Male; D010778:Photochemotherapy / Q000009:adverse effects*; D011166:Porphyrins / Q000009:adverse effects; D011467:Prostate / Q000293:injuries*; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects*
D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C063166:tin etiopurpurin