Interaction between a murine myeloma cell line and bone marrow stromal cells.
Intravenous transplantation of an in vitro maintained murine myeloma cell line, 5T33, results in progressive growth in the bone marrow of C57Bl/KaLwRiJ mice. Concurrent with the growth of the tumor in vivo, the bone marrow stromal cells are inhibited, as assayed by their ability to form stromal cell foci and long-term monolayers in vitro. Inhibition of normal mouse marrow stromal cell growth also occurs when 5T33 cells are added to the marrow cells in vitro, and contact between the marrow and 5T33 cells is not necessary to achieve inhibition, indicating secretion of one or more diffusible inhibitory factors.
Bradley
T R
TR
Trescowthick Research Laboratories, Melbourne, Australia.
Kriegler
A B
AB
Verschoor
S M
SM
Tzelepis
S M
SM
Cooper
I A
IA
D000818:Animals; D001685:Biological Factors / Q000378:metabolism; D001853:Bone Marrow / Q000473:pathology*; D002455:Cell Division; D002478:Cells, Cultured; D003238:Connective Tissue / Q000473:pathology*; D018450:Disease Progression; D006131:Growth Inhibitors / Q000378:metabolism; D007275:Injections, Intravenous; D051379:Mice; D008810:Mice, Inbred C57BL; D009101:Multiple Myeloma / Q000473:pathology*; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000637:transplantation; D014410:Tumor Stem Cell Assay
D001685:Biological Factors; D006131:Growth Inhibitors