title: The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune response in infants.
abstract: The effects of measles immunization on immune responses in infants and the roles of vaccine strain and age of immunization are not known. Eighty-eight children were immunized at 6 or 9 months of age with the Edmonston-Zagreb (EZ) or Schwarz (SW6, SW9) strain of measles vaccine. Children were studied before and 2 weeks and 3 months after immunization. Seroconversion was similar, but geometric mean neutralizing titers at 3 months differed by vaccine group: SW9, 1367 mIU/mL; SW6, 982; and EZ, 303 (P = .003). Mitogen-induced lymphoproliferation was decreased at 2 weeks in the SW9 group and at 3 months in all groups and was negatively correlated with measles antibody level at 3 months (r = -.387, P = .003). CD8 T cells, soluble CD8, neopterin, and beta2-microglobulin were increased at 2 weeks in the SW9 group, and soluble CD8 and beta2-microglobulin remained elevated at 3 months. Therefore, measles immunization resulted in suppression of lymphoproliferation, which was most evident in infants with the highest antibody responses and most immune activation.
authors.affiliation: Department of Paediatrics and Child Health, University of Cape Town, South Africa.
authors.forename: G D
authors.initials: GD
authors.lastname: Hussey
authors.forename: E A
authors.initials: EA
authors.lastname: Goddard
authors.forename: J
authors.initials: J
authors.lastname: Hughes
authors.forename: J J
authors.initials: JJ
authors.lastname: Ryon
authors.forename: M
authors.initials: M
authors.lastname: Kerran
authors.forename: E
authors.initials: E
authors.lastname: Carelse
authors.forename: P M
authors.initials: PM
authors.lastname: Strebel
authors.forename: L E
authors.initials: LE
authors.lastname: Markowitz
authors.forename: J
authors.initials: J
authors.lastname: Moodie
authors.forename: P
authors.initials: P
authors.lastname: Barron
authors.forename: Z
authors.initials: Z
authors.lastname: Latief
authors.forename: R
authors.initials: R
authors.lastname: Sayed
authors.forename: D
authors.initials: D
authors.lastname: Beatty
authors.forename: D E
authors.initials: DE
authors.lastname: Griffin
mesh_terms: D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology*; D016131:Lymphocyte Subsets; D008297:Male; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D019798:Neopterin; D012727:Sex Characteristics; D014611:Vaccination; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D000914:Antibodies, Viral; D016827:CD8 Antigens; D008458:Measles Vaccine; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin