Eukaryotic gene expression: metabolite control by amino acids.
Our understanding of the metabolite control in mammalian cells lags far behind that in prokaryotes. This is particularly true for amino-acid-dependent gene expression. Few proteins have been identified for which synthesis is selectively regulated by amino-acid availability, and the mechanisms for control of transcription and translation in response to changes in amino-acid availability have not yet been elucidated. The intimate relationship between amino-acid supply and the fundamental cellular process of protein synthesis makes amino-acid-dependent control of gene expression particularly important. Future studies should provide important insight into amino-acid and other nutrient signaling pathways, and their impact on cellular growth and metabolism.
Laine
R O
RO
Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville 32610, USA.
Hutson
R G
RG
Kilberg
M S
MS
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D001217:Aspartate-Ammonia Ligase / Q000235:genetics; D001419:Bacteria / Q000235:genetics*; D005658:Fungi / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D012269:Ribosomal Proteins / Q000235:genetics
D000596:Amino Acids; D012269:Ribosomal Proteins; D001217:Aspartate-Ammonia Ligase