title: [The evolution over time of the in-vitro resistance of Plasmodium falciparum to antimalarial drugs in 2 areas of the Brazilian Amazonia with distinct socioeconomic and geographic characteristics].
abstract: We evaluated the temporal progression of in vitro P. falciparum resistance to chloroquine, amodiaquine, quinine and mefloquine in two areas with distinct socioeconomical and geographical characteristics: Lourenço, in Amapá state and Paragominas, in Pará state. The former region is essentially an "open" gold mining camp, whereas the latter is one currently undergoing a colonization settlement process, in addition to expanding economical activities which mainly include cattle raising and wood exploitation. Our results show high resistance rates to chloroquine in the two study areas: 79.8% and 68.4% in Lourenço and Paragominas, respectively. Variations in the response of P. falciparum to both amodiaquine and quinine were recorded throughout the study period. On the other hand, no mefloquine P. falciparum resistant strains could be identified, despite the tact we had noted a decrease in sensitivity to this antimalarial drug throughout the study period.
authors.affiliation: Serviço de Ecologia Humana e Meio Ambiente, Instituto Evandro Chagas, Fundação Nacional de Saúde (FNS), Belém, PA.
authors.forename: A A
authors.initials: AA
authors.lastname: Couto
authors.forename: V S
authors.initials: VS
authors.lastname: Calvosa
authors.forename: M A
authors.initials: MA
authors.lastname: Santos
authors.forename: J M
authors.initials: JM
authors.lastname: de Souza
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000037:antagonists & inhibitors*; D001938:Brazil; D004351:Drug Resistance; D005260:Female; D005843:Geography; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D012959:Socioeconomic Factors; D013997:Time Factors
chemical_list: D000962:Antimalarials
vernacular_title: Evolução temporal da resistência in vitro do Plasmodium falciparum às drogas antimaláricas em duas áreas da Amazônia Brasileira com distintas características sócio-econômicas e geográficas.