2-Diazopyrroles: synthesis and antileukemic activity.
The title compounds were synthesised in preparative yields by diazotization of the corresponding 2-aminopyrroles. In preliminary screening tests as antileukemic agents they showed modest activity against the murine and human leukemic cell lines FLC and K562S and their multidrug-resistant daunorubicin selected sublines.
Cirrincione
G
G
Istituto Farmacochimico, Università di Palermo, Italy.
Almerico
A M
AM
Diana
P
P
Grimaudo
S
S
Barraja
P
P
Dattolo
G
G
Aiello
E
E
Mingola
F
F
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011758:Pyrroles