title: [Importance of genetic factors in pathogenesis of subacute spongiform viral encephalitis].
abstract: Recently there has been achieved a substantial progress in research concerning pathogenesis of subacute spongiform viral encephalopathies. For this group of disorders, there has been found a common unconventional virus - proteinaceous infectious particle (PrP). There has been recognised a molecular mass, biochemical composition and physicochemical properties of this infectious form. Mutations of scrapie amyloid precursor gene discovered in Gerstmann-Sträussler-Scheinker syndrome (GSS) and familial cases of Creutzfeldt-Jakob disease (CJD) have been revealed. Nowadays examinations in the field of relationships between prion protein and mutations of scrapie precursor gene are continued.
authors.affiliation: I Klinika Neurologii Slaskiej Akademii Medycznej w Katowicach.
authors.forename: W
authors.initials: W
authors.lastname: Wierzba
authors.forename: A
authors.initials: A
authors.lastname: Wajgt
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics; D016098:Gerstmann-Straussler-Scheinker Disease / Q000235:genetics; D006801:Humans; D009154:Mutation; D018621:PrPC Proteins / Q000235:genetics; D017096:Prion Diseases / Q000235:genetics*
chemical_list: D018621:PrPC Proteins
vernacular_title: Znaczenie czynników genetycznych w patogenezie podostrych transmisyjnych encefalopatii gabczastych.