title: Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.
abstract: Human somatostatin receptor 3 ('hsstr3') was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.
authors.affiliation: Howard Hughes Medical Institute, University of Virginia, Charlottesville, VA 22908, U.S.A.
authors.forename: D B
authors.initials: DB
authors.lastname: Reardon
authors.forename: S L
authors.initials: SL
authors.lastname: Wood
authors.forename: D L
authors.initials: DL
authors.lastname: Brautigan
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
authors.forename: P
authors.initials: P
authors.lastname: Dent
authors.forename: T W
authors.initials: TW
authors.lastname: Sturgill
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002461:Cell Line, Transformed; D004789:Enzyme Activation; D011905:Genes, ras; D051379:Mice; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D019908:Proto-Oncogene Proteins c-raf; D013004:Somatostatin / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D011518:Proto-Oncogene Proteins; D013004:Somatostatin; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf; D017027:Protein Tyrosine Phosphatases