[The presence of IgE on limbal Langerhans cells in patients with atopicdermatitis].
Limbal conjunctival biopsies from 8 patients with atopic dermatitis and from 5 age-matched healthy individuals undergoing cataract or retinal detachment surgery were analyzed by light microscopy and immunological techniques. They were immuno-double labelled with anti-CD1a and anti-IgE or anti-CD23 (IgE receptor). In the specimens from atopic dermatitis 24 approximately 75% of positive anti-CD1a staining cells were double-stained by anti-IgE. Weak positive immuno-double stained cells with anti-CD23 were also observed, but less than with anti-IgE. The ratio of positive anti-IgE double-stained cells to positive anti-CD1a stained cells seemed to be parallel to serum IgE level, but not significant. The presence of IgE and CD23 (IgE receptor) on conjunctival Langerhans cells seems to have a positive effect on IgE-dependent antigen presentation.
Nii
S
S
Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan.
Idei
T
T
Katsura
H
H
Mashima
Y
Y
D000328:Adult; D002386:Cataract / Q000276:immunology; D003228:Conjunctiva / Q000166:cytology*; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D016555:Matched-Pair Analysis; D017455:Receptors, IgE / Q000378:metabolism; D012163:Retinal Detachment / Q000276:immunology / Q000601:surgery
D017455:Receptors, IgE; D007073:Immunoglobulin E