title: YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers.
abstract: To facilitate functional analysis of the Xq26 region, the physical map has been extended across 9 Mb with 192 YACs and markers including 90 STSs (sequence-tagged sites) and 50 hybridization probes. Six genes and six ESTs are localized. In addition, 32 markers that detect polymorphism permit an integration of physical with genetic linkage data. The localizations of eight uncloned disease genes are thereby delimited on the physical map. The data also suggest a possible gradient of recombination across the cytogenetic band, with little or no recombination reported in the centromeric 3.5-4 Mb.
authors.affiliation: Department of Molecular Microbiology and Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.
authors.forename: G
authors.initials: G
authors.lastname: Pilia
authors.forename: S
authors.initials: S
authors.lastname: MacMillan
authors.forename: R
authors.initials: R
authors.lastname: Nagaraja
authors.forename: S
authors.initials: S
authors.lastname: Mumm
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: D
authors.initials: D
authors.lastname: Schlessinger
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D018244:Chromosomes, Artificial, Yeast; D005819:Genetic Markers; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D016615:Telomere / Q000235:genetics; D014960:X Chromosome
chemical_list: D005819:Genetic Markers