Post-prandial thermogenesis with ephedrine, caffeine and aspirin in lean, pre-disposed obese and obese women.
OBJECTIVE
To determine whether or not aspirin further potentiates the greater post-prandial thermogenesis induced by ephedrine with caffeine.


METHODS
Determination of the acute metabolic rate response to the following treatments: 1050 kJ liquid meal (M); meal plus ephedrine (30 mg) and caffeine (100 mg) (MEC) or meal plus ephedrine, caffeine and aspirin (300 mg) (MECA).


METHODS
Lean, pre-disposed obese and obese women (n = 10 each group).


METHODS
Pre- and post-treatment metabolic rate determinations via indirect calorimetry. Post-treatment measurements made at 20 min intervals for a total of 160 min.


RESULTS
In all groups, metabolic rate increased significantly more following the MEC or MECA, compared to the meal only (p < 0.05). The obese group had a significantly greater absolute increase in metabolic rate following the MECA and MEC compared to both the lean and pre-disposed obese groups (p < 0.05). Metabolic rate remained elevated at the end of the 160 min following all treatments.


CONCLUSIONS
Aspirin does not further potentiate the acute thermic effect of ephedrine and caffeine with a meal. However, the full thermogenic response was not measured and longer duration studies are necessary to confirm these results.
Horton
T J
TJ
Department of Nutrition and Dietetics, King's College, University of London, Kensington, UK.
Geissler
C A
CA
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001481:Basal Metabolism; D001824:Body Constitution; D015992:Body Mass Index; D001833:Body Temperature Regulation / Q000187:drug effects*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002153:Calorimetry, Indirect; D004809:Ephedrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005502:Food; D006801:Humans; D007700:Kinetics; D009765:Obesity / Q000378:metabolism*
D002110:Caffeine; D004809:Ephedrine; D001241:Aspirin