title: [Alpha-1-antitrypsin, albumin and whole protein in meconium and stools during the first days of life in the neonate].
abstract: Samples of meconium and first stools were taken prospectively over the first 3 days of life from healthy, term neonates from uncomplicated deliveries (control group) and from neonates that were hypertrophic, premature, delivered through a Cesarian section or born to diabetic mothers. The variability and diagnostic value of determining alpha-1-antitrypsin (AAT), albumin and total protein in these samples was analyzed. Both the level and dynamics of AAT in the first three days of life differed between the study and control groups. No correlation was found between the AAT and albumin concentrations in the studied material. An increase in total protein content over control values was found in the same neonates that showed elevated AAT concentration in meconium and stools. The concomitant determination of AAT, albumin and total protein in stool makes it possible to discriminate between these groups of neonates with a 91.7% accuracy.
authors.affiliation: Katedra i Zakład Biochemii i Chemii Klinicznej Akademii Medycznej w Warszawie.
authors.forename: B
authors.initials: B
authors.lastname: Lisowska-Myjak
authors.forename: J
authors.initials: J
authors.lastname: Pachecka
authors.forename: B
authors.initials: B
authors.lastname: Antoniewicz
authors.forename: A
authors.initials: A
authors.lastname: Krawczyk
authors.forename: A
authors.initials: A
authors.lastname: Jóźwik
mesh_terms: D000418:Albumins / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002585:Cesarean Section; D005243:Feces / Q000737:chemistry*; D005260:Female; D005320:Fetal Macrosomia / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism; D008470:Meconium / Q000737:chemistry; D011247:Pregnancy; D011446:Prospective Studies; D011506:Proteins / Q000032:analysis*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
chemical_list: D000418:Albumins; D015415:Biomarkers; D011506:Proteins; D000515:alpha 1-Antitrypsin
vernacular_title: Alfa-1-antytrypsyna, albumina i białko całkowite w smółkach i kale oddawanym w pierwszych dniach zycia noworodka.