Experimental study of combined hyperthermic and photodynamic therapy on carcinoma in the mouse.
OBJECTIVE
This study investigates the cytotoxic effect of photodynamic therapy using high-power laser irradiation on cancer cells.


METHODS
High- or low-power irradiation from a pulsed Nd:YAG dye laser with or without a photosensitizer was administered to an NR-S1 carcinoma in the mouse dorsum.


RESULTS
Photodynamic therapy with high-power laser irradiation yielded better results than conventional photodynamic therapy or hyperthermia with high-power laser irradiation.


CONCLUSIONS
Photodynamic therapy with high-power laser irradiation is more effective because it generates both a hyperthermic and a photodynamic effect.
Uehara
M
M
Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
Inokuchi
T
T
Sano
K
K
D000538:Aluminum Silicates; D000818:Animals; D000963:Antimetabolites; D001973:Bromodeoxyuridine; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000627:therapeutic use; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009336:Necrosis; D009354:Neodymium; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy*; D015019:Yttrium
D000538:Aluminum Silicates; D000963:Antimetabolites; D006415:Hematoporphyrins; D017319:Photosensitizing Agents; D009354:Neodymium; D015019:Yttrium; D001973:Bromodeoxyuridine