Angiotensin and the brain.
A brief account for the renal renin-angiotensin system (RAS), its inhibitors and receptors, as for the presence of an intrinsic cerebral RAS is initially provided. The review is then focused upon the circumventricular organs as cerebral targets for blood-borne angiotensin II (Ang II) and on centrally mediated Ang II effects. These concern influences upon the cardiovascular system, water balance, sodium balance, and ACTH-cortisol secretion.
Andersson
B
B
Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Eriksson
S
S
Rundgren
M
M
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D057911:Angiotensin Receptor Antagonists; D011945:Receptors, Angiotensin; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone