title: Diabetes mellitus, a predictor of morbidity and mortality in the Studies of Left Ventricular Dysfunction (SOLVD) Trials and Registry.
abstract: Diabetes is an independent predictor of morbidity and mortality in patients with symptomatic heart failure, patients with asymptomatic left ventricular dysfunction (defined as an ejection fraction of 35% or less), and in a broader registry population with less stringent entry criteria. Although the SOLVD Trials made a major clinical contribution by proving the value of enalapril, diabetes remains a significant predictor of outcome even after adjusting for treatment with enalapril.
authors.affiliation: University of Medicine and Dentistry-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Shindler
authors.forename: J B
authors.initials: JB
authors.lastname: Kostis
authors.forename: S
authors.initials: S
authors.lastname: Yusuf
authors.forename: M A
authors.initials: MA
authors.lastname: Quinones
authors.forename: B
authors.initials: B
authors.lastname: Pitt
authors.forename: D
authors.initials: D
authors.lastname: Stewart
authors.forename: T
authors.initials: T
authors.lastname: Pinkett
authors.forename: J K
authors.initials: JK
authors.lastname: Ghali
authors.forename: A C
authors.initials: AC
authors.lastname: Wilson
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000401:mortality; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D016017:Odds Ratio; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000188:drug therapy / Q000401:mortality
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril