Resistance to cytotoxic therapy: a speculative overview.
While most recent studies have focused on the MDR1 gene and other similar types of multidrug resistance, two other phenomena (inhibition of the apoptotic pathway and regrowth resistance) have the potential for producing a much broader type of resistance to cytotoxic therapy. This speculative review discusses the potential contribution of these types of resistance and the possible interrelationships between the various types of resistance to cytotoxic therapy. The need for new approaches to assess the effects of biological agents is discussed.
Preisler
H D
HD
Rush Cancer Institute, Chicago, IL, USA.
D002455:Cell Division; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D015870:Gene Expression; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology