title: The evolutionary conservation of the splicing apparatus between fission yeast and man.
abstract: The removal of intervening sequences from pre-mRNA is an important step in gene regulation. Pre-mRNA processing takes place within the spliceosome, a dynamic structure composed of small nuclear RNA (snRNA) and proteins. The function of the spliceosome is currently being studied in many eukaryotic systems including mammal and yeast. Here we review pre-mRNA splicing in fission yeast and man and propose that spliceosomal structure and function has been evolutionarily conserved between the two organisms.
authors.affiliation: Finch University of Health Sciences, Chicago Medical School, North Chicago, IL 60064, USA.
authors.forename: K
authors.initials: K
authors.lastname: Wentz-Hunter
authors.forename: J
authors.initials: J
authors.lastname: Potashkin
mesh_terms: D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D019143:Evolution, Molecular; D006801:Humans; D009687:Nuclear Proteins; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics*; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000235:genetics / Q000378:metabolism; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism*; D017381:Spliceosomes / Q000235:genetics / Q000378:metabolism; D000072668:Splicing Factor U2AF
chemical_list: D009687:Nuclear Proteins; D012322:RNA Precursors; D012331:RNA, Fungal; D012342:RNA, Small Nuclear; D017412:Ribonucleoprotein, U1 Small Nuclear; D012261:Ribonucleoproteins; D000072668:Splicing Factor U2AF; C000607494:U2AF2 protein, human