Clinical comparison of three labeled-antibody immunoassays of free triiodothyronine.
Three labeled-antibody immunoassays of free triiodothyronine (FT3) were studied in hyperthyroid patients, patients with nonthyroidal illness, and patients being treated with amiodarone; we also studied sera presenting known interferences (n for all groups = 465). The results were compared with those of a one-step labeled-analog assay. The precision of the two automated assays were similar to that of the manual assays. The three labeled-antibody FT3 assays demonstrated a satisfactory diagnostic performance for confirming hyperthyroidism and robustness to interference; nevertheless, two assays displayed unusual behavior in some patients with nonthyroidal illness, with chronic renal failure, or after amiodarone therapy.
Piketty
M L
ML
Laboratoire RIA, CH Sainte Anne, Paris, France.
d'Herbomez
M
M
Le Guillouzic
D
D
Lebtahi
R
R
Cosson
E
E
Dumont
A
A
Dilouya
A
A
Helal
B O
BO
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000627:therapeutic use; D001322:Autoanalysis / Q000706:statistics & numerical data; D001323:Autoantibodies / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D007118:Immunoassay / Q000379:methods* / Q000706:statistics & numerical data*; D007676:Kidney Failure, Chronic / Q000097:blood; D008875:Middle Aged; D011786:Quality Control; D012016:Reference Values; D012680:Sensitivity and Specificity; D013974:Thyroxine / Q000276:immunology; D014284:Triiodothyronine / Q000097:blood* / Q000276:immunology
D001323:Autoantibodies; D014284:Triiodothyronine; D000638:Amiodarone; D013974:Thyroxine