[Hemoglobin oxygen-transport activity in lymphosarcomas].
To evaluate oxygen transport function of Hb in lymphoid sarcomas, 15 patients aged 16-63 were examined for Hb oxygen capacity, concentrations of fetal Hb and creatinin, basic ligands H+, CO2, 2,3-diphosphoglycerate (2,3-DPG). Oxy-Hb dissociation curves were plotted. The patients' blood contained HbF in elevated quantities, whereas red cells had high creatinin. This emphasizes the role of hemolysis in genesis of anemia in lymphosarcomas. 70% of the examinees retained normal Hb affinity to oxygen in vivo, in 30% this affinity exceeded the standard. Compensatory mechanism responsible for low Hb affinity to oxygen in this disease fails. Therefore lymphosarcoma patients with anemia need early replacement hemotransfusions.
Karpova
I V
IV
Dmitrieva
M G
MG
Pivnik
A V
AV
Zybunova
E E
EE
Lutsenko
I N
IN
D019794:2,3-Diphosphoglycerate; D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology; D001692:Biological Transport; D002245:Carbon Dioxide / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate; D002245:Carbon Dioxide; D005319:Fetal Hemoglobin; D010100:Oxygen
Kislorodtransportnaia aktivnost' gemoglobina pri limfosarkomakh.