[Chronic urticaria caused by penicillin. Results of monitoring cases of acute penicillin urticaria which developed into chronic urticaria].
Penicillin is known to cause allergic reactions with different clinical manifestations and possible immunologic mechanisms. The purpose of this study was to follow cases of established hypersensitivity to penicillin and its possible development into chronic urticaria. 35 patients with a clinical picture of acute urticaria and with or without angioedema were examined. Three kinds of tests to penicillin were performed: patch test, scarification test and PPL test. Hypersensitivity to penicillin was confirmed in 12 (34.27%) patients with positive PPL test. Seven (58.33%) out of these 12 developed the clinical picture of chronic urticaria. As food was assumed to be the hidden source of penicillin, eliminatory diet was included. In 4 (57.14%) patients there was a complete remission of the disease during the course of diet without milk and milk products (intradermal test to milk and specific IgE antibodies were negative). The gathered results show that acute urticaria caused by penicillin can get a chronic character. It is the consequence of prolonged penicillin's activity in some so called "hidden sources of penicillin".
Poljacki
M
M
Klinika za infektivne i dermatoveneroloske bolesti, Medicinski fakultet, Novi Sad.
Jovanović
M
M
Duran
V
V
Tasić
S
S
Subotić
M
M
D000208:Acute Disease; D002908:Chronic Disease; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D010406:Penicillins / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced / Q000473:pathology*
D010406:Penicillins
Hronicna urtikarija izazvana penicilinom. Rezultati praćenja slucajeva akutne urtikarije na penicilin koji su se razvili u hronicnu urtikariju.