title: Cytomegalovirus involving gastrointestinal tract in renal transplant recipients.
abstract: Infection due to cytomegalovirus (CMV) is a substantial cause of mortality and morbidity among renal transplant recipients but the prognosis of the disease has changed dramatically since the introduction of ganciclovir (GAN). During a period of 5 years we treated 54 patients who developed CMV disease. From this group of patients we identified 7 patients with primary gastrointestinal tract (GIT) CMV disease who received treatment with GAN. Tissue diagnosis was made by endoscopy of the upper GIT (6 patients) or sigmoidoscopy (one patient) and histological examination. All patients improved after treatment with GAN; three patients required additional treatment for recurrent CMV disease and recovered, and 1 patient relapsed without GIT involvement (P = 0.014). Recurrent CMV disease was more severe (mean score of 15 in relapse compared to 7 in the first episode). We believe relapse to be more common and the disease to be more severe in the presence of GIT involvement suggesting that a longer duration of treatment with GAN may be required in this clinical manifestation of CMV disease.
authors.affiliation: Renal Transplant Unit of Cardiff Royal Infirmary, University of Glamorgan, Wales.
authors.forename: B M
authors.initials: BM
authors.lastname: Shrestha
authors.forename: D
authors.initials: D
authors.lastname: Parton
authors.forename: A
authors.initials: A
authors.lastname: Gray
authors.forename: D
authors.initials: D
authors.lastname: Shephard
authors.forename: D
authors.initials: D
authors.lastname: Griffith
authors.forename: D
authors.initials: D
authors.lastname: Westmoreland
authors.forename: P
authors.initials: P
authors.lastname: Griffin
authors.forename: R
authors.initials: R
authors.lastname: Lord
authors.forename: J R
authors.initials: JR
authors.lastname: Salaman
authors.forename: R H
authors.initials: RH
authors.lastname: Moore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D005773:Gastroscopy; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012812:Sigmoidoscopy
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir