title: Fluticasone propionate: safety profile.
abstract: Fluticasone propionate is a potent fluorinated corticosteroid used for the topical therapy of dermatoses and as inhalation therapy for bronchial asthma and allergic rhinitis. This agent has a good safety profile with a low propensity for systemic side effects, such as suppression of the hypothalamic-pituitary-adrenal (HPA) axis, and a low incidence of local side effects such as pruritus, burning, or skin atrophy. The pharmacologic properties of fluticasone propionate-including high lipophilicity, high selectivity and affinity for the glucocorticoid receptor, low systemic absorption, and rapid metabolism and clearance-combine to give fluticasone propionate a high therapeutic index.
authors.affiliation: Glaxo Wellcome, Stockley Park West, Uxbridge, Middlesex, England.
authors.forename: M
authors.initials: M
authors.lastname: Johnson
mesh_terms: D000287:Administration, Topical; D000730:Androstadienes / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000068298:Fluticasone; D005938:Glucocorticoids; D006801:Humans; D012449:Safety
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D000068298:Fluticasone