Effect of HLA-DR3 gene expression on cadaveric renal allograft survival in blacks.
The effect of HLA-DR3 gene expression was studied in black cadaveric renal allograft recipients of organs from the same donor race. From January 1984 to June 1992, 70 patients received cadaveric renal allografts at the Medical University of Southern Africa (MEDUNSA). The average age and F:M ratio was 30 years and 1: 1.2 respectively. HLA-A, B and DR matching was zero to one in 80%. Actuarial graft survival at yearly intervals in 22 HLA-DR3 gene expressors was 62, 55, 38, 30 and 24% as compared to 82, 78, 70, 64 and 58% in 48 non-HLA DR3 gene expressors (Breslow p = 0.01 and Mantel-Cox p = 0.05). There was no statistical differences in creatinine values associated with HLA-DR3 gene expression during the 1st year after transplantation. Renal allografts were lost from rejection in 9 out of 16 HLA-DR3 gene expressors as compared to 19 out of 29 non-HLA DR3 gene expressors (Fisher's exact test p = 0.8). HLA-DR3 gene expression is a risk factor for earlier graft loss in black South Africans.
Ngcobo
T K
TK
Department of Surgery, Medical University of Southern Africa (MEDUNSA), South Africa.
Becker
P
P
Modiba
M C
MC
D000293:Adolescent; D000328:Adult; D044383:Black People / Q000235:genetics*; D002102:Cadaver; D005260:Female; D015870:Gene Expression; D006085:Graft Survival; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014184:Transplantation, Homologous
D015803:HLA-DR3 Antigen