[Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter].
Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel-coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 atm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high-performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g.wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.
Imanishi
T
T
Department of Cardiology, Wakayama Medical College, Japan.
Arita
M
M
Shiizaki
K
K
Ohmori
H
H
Hamada
M
M
Hano
T
T
Nishio
I
I
Tomobuchi
Y
Y
Nakai
K
K
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D000818:Animals; D000991:Antithrombins / Q000378:metabolism*; D001120:Arginine / Q000031:analogs & derivatives; D002404:Catheterization; D003331:Coronary Vessels / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010875:Pipecolic Acids / Q000378:metabolism*; D011092:Polyethylene Glycols; D011817:Rabbits; D013449:Sulfonamides
D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D001120:Arginine; C031942:argatroban