Parasite-specific lactate dehydrogenase for the diagnosis of Plasmodium falciparum infection in an endemic area in west Uganda.
The measurement of parasite lactate dehydrogenase (pLDH) has been presented as an easy and rapid method for the diagnosis of malaria in humans. In order to evaluate the sensitivity and specificity of such a test we examined blood samples from 429 Ugandan patients. While pLDH activity was significantly linked to parasitaemia, sensitivity and specificity were found to be rather low at 58.8 and 62.2% respectively. The positive and negative predictive values failed to meet necessary standards. We conclude that the methods of measurement of pLDH activity in malaria infection, although potentially useful for the fast diagnosis of malaria, need to be improved to be of true value in endemic areas.
Jelinek
T
T
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
Kilian
A H
AH
Henk
M
M
Mughusu
E B
EB
Nothdurft
H D
HD
Löscher
T
T
Knobloch
J
J
Van Sonnenburg
F
F
D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D016014:Linear Models; D016778:Malaria, Falciparum / Q000097:blood* / Q000201:enzymology* / Q000469:parasitology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014454:Uganda
D007770:L-Lactate Dehydrogenase