A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.
Savitsky
K
K
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Ziv
Y
Y
Bar-Shira
A
A
Gilad
S
S
Tagle
D A
DA
Smith
S
S
Uziel
T
T
Sfez
S
S
Nahmias
J
J
Sartiel
A
A
Eddy
R L
RL
Shows
T B
TB
Collins
F S
FS
Shiloh
Y
Y
Rotman
G
G
D000595:Amino Acid Sequence; D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics; D001483:Base Sequence; D002460:Cell Line; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D006224:Cricetinae; D018076:DNA, Complementary; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D011544:Pseudogenes; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D018911:Trinucleotide Repeats
D018076:DNA, Complementary; D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases