The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development.
Members of the winged helix family of transcription factors are required for the normal embryonic development of the mouse. Using the interspecific backcross panel from The Jackson Laboratory, we have determined the chromosomal locations of four genes that encode winged helix containing proteins. Mf1 was assigned to mouse Chromosome 8, Mf2 to Chromosome 4, Mf3 to Chromosome 9, and Mf4 to Chromosome 13. Since Mf3 is located in a region of Chromosome 9 containing many well-characterized mouse mutations such as short ear (se), ashen (ash), and dilute (d), we have analyzed deletion mutants to determine the location of Mf3 more precisely.
Labosky
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Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee, 37232-2175, USA.
Winnier
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Sasaki
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Blessing
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Hogan
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D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D015342:DNA Probes; D018076:DNA, Complementary; D018507:Gene Expression Regulation, Developmental; D005819:Genetic Markers; D015698:Genomic Library; D051379:Mice / Q000235:genetics*; D008817:Mice, Mutant Strains; D005810:Multigene Family; D009115:Muridae; D015183:Restriction Mapping; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
D015342:DNA Probes; D018076:DNA, Complementary; D005819:Genetic Markers; D014157:Transcription Factors