title: Qualitative analysis of biochemical reaction systems.
abstract: The qualitative analysis of biochemical reaction systems is presented. A discrete event systems approach is used to represent and analyze bioreaction pathways. The approach is based on Petri nets, which are particularly suited to modeling stoichiometric transformations, i.e. the inter-conversion of metabolites in fixed proportions. The properties and methods for the analysis of Petri nets, along with their interpretation for biochemical systems, are presented. As an example, the combined glycolytic and pentose phosphate pathway of the erythrocyte cell is presented to illustrate the concepts of the methodology.
authors.affiliation: Dept. of Chemical Engineering, Northwestern University, Evanston, IL 60208-3120, USA.
authors.forename: V N
authors.initials: VN
authors.lastname: Reddy
authors.forename: M N
authors.initials: MN
authors.lastname: Liebman
authors.forename: M L
authors.initials: ML
authors.lastname: Mavrovouniotis
mesh_terms: D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D003198:Computer Simulation; D004912:Erythrocytes / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D008962:Models, Theoretical; D010427:Pentose Phosphate Pathway / Q000502:physiology*