Adherence of nontypeable Haemophilus influenzae to respiratory epithelium of otitis-prone and normal children.
Three hundred six children were enrolled at birth in a prospective study of otitis media and followed up for 2 years. Adherence of nontypeable Haemophilus influenzae to buccal epithelial cells was compared between otitis-prone children and age- and sex-matched normal controls at birth, 1 year, and 2 years. The mean +/- SD/median percent adherence was similar for the two groups at birth (1.6 +/- 2.3/1.0 versus 1.2 +/- 1.4/1.0; NS) and at 2 years (1.6 +/- 1.7/1.5 versus 2.1 +/- 2.1/1.5; NS). At 1 year of age the adherence rate for the otitis-prone group (2.4 +/- 2.6/1.0) was statistically greater than that for the control group (1.0 +/- 1.3/0.0; p < .02). Because this difference is probably clinically insignificant, other explanations must be sought for the increased colonization rates of nontypeable H influenzae observed in otitis-prone children.
Faden
H
H
Department of Pediatrics, State University of New York at Buffalo, USA.
Duffy
L
L
Foels
T
T
Hong
J J
JJ
D001422:Bacterial Adhesion; D002675:Child, Preschool; D004848:Epithelium / Q000382:microbiology; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010033:Otitis Media / Q000382:microbiology*; D010256:Paranasal Sinuses / Q000382:microbiology*; D011446:Prospective Studies