Effect of intratesticular administration of oxytocin on testicular steroidogenesis in immature rats.
The possible physiological role of testicular oxytocin in testicular steroidogenesis was studied in immature rats. In 5-, 9-, and 25-day-old animals one of the testes was injected with 20, 50, and 200 ng of oxytocin, respectively, then the contralateral gonad was removed. Rats were killed 1 h, 1 day, or 7 days post-surgery. In each age group studied intratesticular injection of oxytocin resulted in a significant increase in basal testosterone secretion in vitro and/or serum testosterone concentration. Data indicate that in immature rats oxytocin of testicular origin might act as a local stimulator of steroidogenesis.
Gerendai
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I
2nd Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Csernus
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V
D000818:Animals; D005260:Female; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood; D013997:Time Factors
D013739:Testosterone; D010121:Oxytocin