t(1;19)(q23;p13) in a case of acute monocytic leukemia.
Translocation (1;19)(q23;p13) is considered a specific chromosome aberration in acute lymphoblastic leukemia (ALL). We report a case of M5 acute nonlymphocytic leukemia (ANLL) with t(1;19). In all mitoses studied from peripheral blood (PB) cells, the pathological karyotype 51,XX,t(1;19)(q23;p13),+8, +der(19)t(1;19)(q23;p13), +3mar was detected. No rearrangement of the E2A gene was detected. We believe this case shows that cytogenetically indistinguishable aberrations may be accompanied by quite different molecular events.
Weh
H J
HJ
Department of Oncology and Hematology, Medical University Clinic, Hamburg, Germany.
Jonveaux
P
P
Seeger
D
D
Felgner
J
J
Hossfeld
D K
DK
D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic