title: Parvalbumin-immunoreactive neurons are not affected by trimethyltin-induced neurodegeneration in the rat hippocampus.
abstract: The present study investigates, by immunocytochemistry, the behavior of different neuronal subpopulations of the rat hippocampus in neurodegenerative processes induced by the neurotoxicant trimethyltin. The calcium-binding proteins calbindin and parvalbumin are used as selective markers of different neuronal subpopulations. The effects of the neurotoxicant were apparent 21 days after a single i.p. administration with severe neuronal loss, which was significant in CAI and CA3, as revealed by cell counts after cresyl violet staining. Immunolabeling with calbindin D28-k (CB) and parvalbumin (PV) indicated severe cell loss of CB-containing neurons, essentially reflecting the generalized neuronal loss, while PV-containing neurons appeared to be selectively spared by the neurotoxicant-induced degeneration.
authors.affiliation: Institute of Anatomy, University of Bari, Bari, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Geloso
authors.forename: P
authors.initials: P
authors.lastname: Vinesi
authors.forename: F
authors.initials: F
authors.lastname: Michetti
mesh_terms: D000818:Animals; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000648:ultrastructure; D007150:Immunohistochemistry; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000276:immunology; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D014298:Trimethyltin Compounds / Q000494:pharmacology*
chemical_list: D010320:Parvalbumins; D014298:Trimethyltin Compounds; C046488:trimethyltin