title: [The basis for the variable effects of thyroid hormones].
abstract: Among physiological reactions of the organism, the multiplicity of action of thyroid hormones is a well known phenomenon. Thyroid hormones (TH) regulate activity of other hormones, receptors for bioactive signals, enzymes, and the function of ion channels. Until triiodothyronine has been identified as a ligand for oncoprotein c-erbA, this broad potency of actions has been mysterious. C-erbA has been recognized to be a transcription factor and an authentic thyroid hormone receptor. Important evidence comes from molecular studies, which have described isoforms of c-erbA and other members of intranuclear receptor family, their heterodimerization, thyroid hormone responsive elements in the target genes, and the existence of the cross-talk mechanism. Till present, much has been learned about TH transcription regulations in vitro. An open question remains whether this regulations are operative also in the intact organism.
authors.affiliation: Ustav experimentálnej endokrinológie SAV, Bratislava.
authors.forename: P
authors.initials: P
authors.lastname: Filipcík
authors.forename: J
authors.initials: J
authors.lastname: Brtko
mesh_terms: D000818:Animals; D006801:Humans; D018774:Oncogene Proteins v-erbA / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D013963:Thyroid Hormones / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D014284:Triiodothyronine / Q000378:metabolism / Q000502:physiology
chemical_list: D018774:Oncogene Proteins v-erbA; D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones; D014284:Triiodothyronine
vernacular_title: Podstata variability úcinku hormónov stítnej zl'azy.