title: Ethiologic treatment of acute and chronic Chagas' Disease [corrected].
abstract: The uncertainties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunosuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardia/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/dat, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia - São Paulo, Brazil.
authors.forename: A A
authors.initials: AA
authors.lastname: Fragata Filho
authors.forename: M A
authors.initials: MA
authors.lastname: da Silva
authors.forename: E
authors.initials: E
authors.lastname: Boainain
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002598:Chagas Cardiomyopathy / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011379:Prognosis; D014344:Trypanocidal Agents / Q000627:therapeutic use*
chemical_list: D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole