title: Isolated limb perfusion of an irradiated foot with tumor necrosis factor, interferon, and melphalan.
abstract: A 57-year-old woman presented with the second recurrence of a high-grade malignant fibrous histiocytoma of the right foot, following previous local resection plus curative adjuvant radiotherapy. The first recurrence of the lesion was treated by isolated limb perfusion with cisplatin; the second recurrence was treated by isolated limb perfusion with tumor necrosis factor, interferon, and melphalan. The tumor and the area that had been irradiated showed a bluish color a few hours after tumor necrosis factor perfusion. Amputation of the right foot and leg below the knee had to be performed because of severe necrosis.
authors.affiliation: Department of Surgical Oncology, Groningen University Hospital, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: van Ginkel
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: A M
authors.initials: AM
authors.lastname: Eggermont
authors.forename: E
authors.initials: E
authors.lastname: Pras
authors.forename: H S
authors.initials: HS
authors.lastname: Koops
mesh_terms: D000671:Amputation, Surgical; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005534:Foot Diseases / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery*; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D008558:Melphalan / Q000008:administration & dosage*; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local; D010477:Perfusion; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons; D002945:Cisplatin; D008558:Melphalan