title: Identifying a neurobiologic basis for drug therapy in TMDs.
abstract: Emerging results from clinical and basic research indicate that persistent pain results in changes in the central nervous system. These changes may help explain chronic orofacial pain and lead to new therapies. The authors review data that support the use of tricyclic antidepressants for neurogenic or atypical pain, and benzodiazepines for musculoskeletal pain. Dentists must weigh the benefits of the chronic administration of a drug for the management of temporomandibular disorders against the equivocal scientific support for the use of many drug classes and the potential for serious toxicity with prolonged administration.
authors.affiliation: US Army Dental Corps, Walter Reed Army Medical Center, Bethesda, MD, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Denucci
authors.forename: R A
authors.initials: RA
authors.lastname: Dionne
authors.forename: R
authors.initials: R
authors.lastname: Dubner
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001569:Benzodiazepines; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003863:Depression / Q000139:chemically induced; D005157:Facial Pain / Q000188:drug therapy* / Q000503:physiopathology*; D005727:Ganglia, Spinal / Q000293:injuries*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents; D002491:Central Nervous System Agents; D009125:Muscle Relaxants, Central; D001569:Benzodiazepines