Intrafollicular hemodynamics before the administration of human chorionic gonadotropin in women at risk of the ovarian hyperstimulation syndrome.
OBJECTIVE
To test the hypothesis that alteration of intrafollicular hemodynamics precedes the ovarian hyperstimulation syndrome (OHSS).


METHODS
A prospective study.


METHODS
The IVF unit and the Doppler imaging laboratory of King's College Hospital, London.


METHODS
Twenty-four women undergoing IVF and considered to have an exaggerated response to ovarian stimulation and hence at risk of OHSS.


METHODS
Transvaginal Doppler imaging of the intrafollicular blood flow was performed before hCG administration to determine the indexes of intrafollicular hemodynamics.


METHODS
Moderate or severe OHSS.


RESULTS
There was no statistically significant difference in mean age (32.63 +/- 1.77 versus 31.48 +/- 3.87), duration of infertility (6.00 +/- 2.19 versus 5.29 +/- 2.73), maximum peak systolic velocity (0.25 +/- 0.16 versus 0.26 +/- 0.21 m/s), mean of six maximal peak systolic velocity (0.15 +/- 0.04 versus 0.21 +/- 0.10), minimum pulsatility index (0.76 +/- 0.26 versus 0.59 +/- 0.23), mean of six minimal pulsatility indexes (0.89 +/- 0.30 versus 0.79 +/- 0.14), minimum resistance index (0.47 +/- 0.06 versus 0.41 +/- 0.10), and mean of six minimal resistance indexes (0.56 +/- 0.05 versus 0.53 +/- 0.06) of intrafollicular blood flow between the women who developed moderate or severe OHSS and matched controls.


CONCLUSIONS
Measurement of intrafollicular hemodynamics before hCG administration does not predict the development of the OHSS.
Oyesanya
O A
OA
King's College School of Medicine and Dentistry, London, United Kingdom.
Parsons
J H
JH
Collins
W P
WP
Campbell
S
S
D000328:Adult; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006439:Hemodynamics; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology / Q000628:therapy; D006080:Ovarian Follicle / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology*; D010062:Ovulation Induction / Q000009:adverse effects; D011446:Prospective Studies; D012307:Risk Factors; D014463:Ultrasonography; D014655:Vascular Resistance
D006063:Chorionic Gonadotropin