title: [The effect of micronized phenofibrate on the lipoproteins of the blood plasma at different initial lipid levels].
abstract: Novel antihyperlipidemic micronized phenofibrate lipantil 200 M was tested for safety and efficacy (one 200 mg capsule a day for 3 months) in 27 patients having cholesterol level above 6.5 mmol/l. The effect emerged upon 1 month of administration and persisted till the end of the treatment. In combined hyperlipidemia triglycerides decreased by 45-60%, total cholesterol and LDL cholesterol by 10-12%. In isolated hyperlipidemia the latter two values appeared lower by 20-23 and 22-27%, respectively. After lipantil 200 M treatment HDL cholesterol went up by 9% in low baseline level (< 1 mmol/l) by 27%. No negative clinico-biochemical shifts were seen, while fibrinogen and uric acid reduced by 16%, apoB by 23-30%. Lipantil 200 M proved active against hyperlipidemia and is recommended for clinical practice.
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
authors.forename: I N
authors.initials: IN
authors.lastname: Ozerova
authors.forename: A M
authors.initials: AM
authors.lastname: Kalinina
authors.forename: L I
authors.initials: LI
authors.lastname: Pavlova
authors.forename: A M
authors.initials: AM
authors.lastname: Olfer'ev
authors.forename: O E
authors.initials: OE
authors.lastname: Mel'kina
authors.forename: M A
authors.initials: MA
authors.lastname: Golubev
authors.forename: R G
authors.initials: RG
authors.lastname: Oganov
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D011345:Fenofibrate / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D013997:Time Factors
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D008074:Lipoproteins; D011345:Fenofibrate
vernacular_title: Vliianie mikronizirovannogo fenofibrata na lipoproteidy plazmy krovi pri razlichnom iskhodnom urovne lipidov.