[Sensitivity to acetylsalicylic acid].
Because of its ability of prevent platelet aggregation, the use of aspirin in Norway is rising abruptly, after some years of fairly low consumption. The author reviews of aspirin-sensitivity, including chronic rhinosinusitis, nasal polyposis and corticosteroid-dependent asthma. Non-steroidal anti-inflammatory drugs have widespread cross-reactions with aspirin, while azo-dyes and food preservatives may induce a similar chronic inflammation of the airways. Why some people develop aspirin-sensitivity is unknown. The basic biochemical mechanisms of aspirin-sensitivity are discussed. Specific treatment based on desensitisation and development of leukotriene receptor antagonists may be rewarding in the future. Possible beneficial or adverse effects of life-long, low-dose use of aspirin on aspirin-sensitivity should be monitored.
Elverland
H H
HH
Ore-nese-halsavdelingen, Regionsykehuset i Tromsø.
D001241:Aspirin / Q000009:adverse effects* / Q000276:immunology; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans
D016861:Cyclooxygenase Inhibitors; D001241:Aspirin
Sensitivitet ved bruk av acetylsalisylsyre.