The heparin-induced thrombocytopenia and thrombosis syndrome: treatment with intraarterial urokinase and systemic platelet aggregation inhibitors.
We report a case of the heparin-induced thrombocytopenia and thrombosis syndrome presenting with acute ischemia of a lower limb. The patient was successfully treated by withdrawal of heparin products, intraarterial urokinase, and platelet anti-aggregation therapy consisting of Dextran and aspirin.
Murphy
K D
KD
Department of Radiology, SUNY Health Sciences Center at Syracuse, NY 13210, USA.
McCrohan
G
G
DeMarta
D A
DA
Shirodkar
N B
NB
Kwon
O J
OJ
Chopra
P S
PS
D000792:Angiography; D001241:Aspirin / Q000008:administration & dosage; D002283:Carcinoma, Bronchogenic / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D007866:Leg / Q000098:blood supply; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*; D014859:Warfarin / Q000008:administration & dosage
D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator; D001241:Aspirin