Assignment of the human prosaposin gene (PSAP) to 10q22.1 by fluorescence in situ hybridization. Giraffidae, okapi (Okapiajohnstoni), and giraffe (Giraffa camelopardalis): evidence for ancestral telomeres at the okapi polymorphic rob (4;26) fusion site.
The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. The present study, using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1.
Bar-Am
I
I
Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Avivi
L
L
Horowitz
M
M
D000818:Animals; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics* / Q000648:ultrastructure; D015342:DNA Probes; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D011498:Protein Precursors / Q000235:genetics*; D049231:Saposins
D015342:DNA Probes; D006023:Glycoproteins; C483345:PSAP protein, human; D011498:Protein Precursors; C483344:Psap protein, mouse; D049231:Saposins