title: [Hemodynamics in arterial hypertension treated with running endurance training or nifedipine therapy].
abstract: This is a report about the therapeutic behavior of blood pressure and heart rate in patients suffering from hypertension. Forty male patients with hypertension (age: 30-53 years) were treated either with running or swimming therapy according to the stamina principle or with nifedipine therapy (40-60 mg/d). Both groups were randomized. Peripheric hemodynamics were investigated by means of the Xenon-133-muscle-clearance (M. tibialis anterior). The values of interest were half-value time (T1/2) and the mean functional vessel diameter. Additionally total peripheric vascular resistance (TPR) and radiocardiographic cardiac output (CO) were measured. Significant decrease of systolic and diastolic blood pressure values at rest were obtained with the therapeutic regimens. CO increased and the TPR decreased. The decrease of blood pressure during physical therapy and with nifedipine therapy also is due to the enhanced microcirculation. Half-value time of muscle clearance (T1/2) and the mean functional vascular diameter were increased significantly.
authors.affiliation: Universitätsklinik und Poliklinik für Physikalische Medizin und Rehabilitation, Universitätsklinikum Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin.
authors.forename: H J
authors.initials: HJ
authors.lastname: Winterfeld
authors.forename: H
authors.initials: H
authors.lastname: Siewert
authors.forename: J
authors.initials: J
authors.lastname: Bohm
authors.forename: R
authors.initials: R
authors.lastname: Möbes
authors.forename: U
authors.initials: U
authors.lastname: Bauer
authors.forename: J
authors.initials: J
authors.lastname: Reisinger
authors.forename: E
authors.initials: E
authors.lastname: Conradi
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000534:rehabilitation*; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D010807:Physical Endurance / Q000502:physiology; D011446:Prospective Studies; D012420:Running / Q000502:physiology; D013550:Swimming / Q000502:physiology
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine
vernacular_title: Hämodynamik bei arterieller Hypertonie unter Lauf-Ausdauertraining oder Nifedipin-Therapie.