title: Arterial therapy of hepatic colorectal metastases.
abstract: Considerable experience of the treatment of irresectable hepatic colorectal metastases has accumulated over the past three decades. In this review, the rationale for hepatic artery treatment of colorectal metastases to the liver is presented and various access techniques and chemotherapeutic agents for infusion are discussed. Randomized trials of hepatic artery chemotherapy (HAC) are analysed, and the promising results of recent studies combining less toxic and more effective agents are summarized. Continuous infusion pumps provide the most reliable and long-lasting access for HAC. Appropriate surgical techniques and medical management can minimize complications. Although tumour progression is best controlled by HAC, a clear-cut survival advantage has yet to be demonstrated. While hepatic artery infusion chemotherapy cannot yet be recommended outside investigational protocols, the experience gained so far should stimulate further studies.
authors.affiliation: Department of Surgery, College of Medicine, University of Florida, Gainesville 32610-0286, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Vauthey
authors.forename: R de W
authors.initials: Rde W
authors.lastname: Marsh
authors.forename: J C
authors.initials: JC
authors.lastname: Cendan
authors.forename: N M
authors.initials: NM
authors.lastname: Chu
authors.forename: E M
authors.initials: EM
authors.lastname: Copeland
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D016032:Randomized Controlled Trials as Topic
chemical_list: D000970:Antineoplastic Agents