[Occurrence of TSH receptor antibodies and thyroid microsomal antibodies in Graves-Basedow disease].
Anti-TSH receptor antibody examination was performed in patients with Basedow-Graves' disease (141 patient: 34 before treatment, 49 during medicamentous therapy, 55 in stable remission and 3 with spontaneous hypothyroidism). The following findings were found: anti-TSH receptor antibodies were positive in 87% of untreated patients; in patients with medicamentous therapy they are in correlation with the metabolic status of the patients; only in 2% of patients in remission findings were high; all of the three patients with spontaneous hypothyroidism have had high titer. Findings of the thyroid microsomal antibodies don't have such regularity: the results were high in 67% of untreated patients; were in correlation with functional status during therapy; highly present in remission (62%) and have high titers in spontaneous hypothyroidism. The gathered results confirm opinions that anti-TSH receptor antibodies are highly etiopathogenetically significant in autoimmune hypothyroidism, but underline that the finding of thyroid microsomal antibodies is not clear enough.
Paunković
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Zdravstveni centar, Zajecar Sluzba za nuklearnu medicinu.
Paunković
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D
D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology*; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D011989:Receptors, Thyrotropin / Q000276:immunology*
D001323:Autoantibodies; D011989:Receptors, Thyrotropin; C056626:thyroid microsomal antibodies
Ucestalost nalaza antitela na TSH receptore i tireoidnih mikrozomskih antitela u Graves-Bazedovljevoj bolesti.