DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families.
Although the human leukocyte antigen DR2/DQw1 allele has been associated with multiple sclerosis, studies of DR2/DQw1 inheritance in multiple sclerosis multiplex families have yielded conflicting results. We examined this question in "high-incidence" families, defined as families with more than 50% of siblings affected. DR2/DQw1 allele frequencies were significantly increased, particularly in mothers and affected siblings (p < 0.0001). The transmission of DR2/DQw1 from both parents was more frequent in affected offspring (p = 0.005). While evidence for segregation of disease with a particular parental allele was lacking in most families, the frequency of haplotype sharing was higher in affected sib pairs (p < 0.01).
Voskuhl
R R
RR
Neuroimmunology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Goldstein
A M
AM
Simonis
T
T
Davey
R J
RJ
McFarland
H F
HF
D000483:Alleles; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D010375:Pedigree
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens