Biological and clinical advances in stem cell expansion.
One of the most exciting areas of hematological research is the ex vivo expansion of peripheral blood progenitor cells (PBPC). Several groups clearly demonstrated that the ex vivo expansion of hematopoietic progenitor cells is possible in the presence of various cytokine combination and/or different feeder layer models. This minireview summarizes recent developments in ex vivo expansion systems as well as first clinical applications.
Lange
W
W
Abteilung Hämatologie und Onkologie, Medizinische Universitätsklinik Freiburg, Germany.
Henschler
R
R
Mertelsmann
R
R
D018952:Antigens, CD34 / Q000378:metabolism; D002455:Cell Division; D002478:Cells, Cultured; D005544:Forecasting; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods / Q000639:trends; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans
D018952:Antigens, CD34; D016298:Hematopoietic Cell Growth Factors