title: Helicobacter pylori-specific IgG in chronic haemodialysis patients: relationship of hypergastrinaemia to positive serology.
abstract: BACKGROUND
  Chronic haemodialysis (HD) patients frequently suffer from dyspeptic symptoms and hypergastrinaemia is a common finding in these patients. Helicobacter pylori (H. pylori) infection is associated with dyspepsia and hypergastrinaemia.
  
  
  METHODS
  The aim of this study was to determine whether H. pylori is frequently found in HD patients and to explore the relationship of H. pylori with dyspeptic symptoms and/or hypergastrinaemia in these patients. Serum H. pylori specific IgG were measured by an in-house enzyme-linked immunosorbent assay (sensitivity and specificity is 97% and 91% respectively) in 103 chronic HD patients. The patients (53 M, 50 F, mean age f60 +/- 13 years) completed a questionnaire exploring the type, frequency and intensity of dyspeptic symptoms. Fasting plasma gastrin levels were also measured. Serum and plasma samples from 103 hospital patients matched for age, sex and dyspepsia were use as controls.
  
  
  RESULTS
  There was no significant difference in terms of serum H. pylori IgG between HD patients and controls (0.977 +/- 0.295 vs 1.046 +/- 0.306 OD respectively). The prevalence of subjects with positive serology was relatively high in both groups, but did not differ between HD patients (73%) and controls (78%). Dyspepsia was reported in 72 (70%) cases. There was no relationship between presence (and grading) of dyspepsia or type of dyspeptic symptoms and H. pylori serology. In the HD group, patients seropositive for H pylori had a significantly higher gastrinaemia than those who were seronegative: 598 +/- 413 ng/ml vs 309 +/- 252 ng/ml (P < 0.0001). The relationship between seropositivity for H. pylori and hypergastrinaemia was significant (P = 0.00038), after adjustment by multiple regression analysis for sex, age, smoking, alcohol, months on dialysis, renal function, drugs, and dyspepsia.
  
  
  CONCLUSIONS
  Data of this study suggest that H. pylori may play a role in contributing to hypergastrinaemia of HD patients.
authors.affiliation: Dipartimento di Medicina Sperimentale, Universitá di R. Calabria, Catanzaro, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Luzza
authors.forename: M
authors.initials: M
authors.lastname: Imeneo
authors.forename: M
authors.initials: M
authors.lastname: Maletta
authors.forename: I
authors.initials: I
authors.lastname: Mantelli
authors.forename: D
authors.initials: D
authors.lastname: Tancre
authors.forename: G
authors.initials: G
authors.lastname: Merando
authors.forename: L
authors.initials: L
authors.lastname: Biancone
authors.forename: F
authors.initials: F
authors.lastname: Pallone
mesh_terms: D004415:Dyspepsia / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005755:Gastrins / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D005755:Gastrins; D007074:Immunoglobulin G