[The cytogenetic reaction of the lymphocytes to in-vitro irradiation in children born to patients after antitumor radio- and chemotherapy].
Stability of genome of children born to patients after antitumor radio- and chemotherapy was studied. For this aim the peripheral lymphocytes were irradiated in vitro at doses 0, 0.25, 0.50, 1.00, and 1.50 Gy of gamma-rays 137Cs, and induced chromosome aberrations on metaphases of cultivated lymphocytes were scored. The data obtained demonstrate an increased chromosomal radiosensitivity of patients' children as compared to the control children. A possible association between the chromosomal instability and the increased risk of cancer is discussed. The children prezygotically exposed to mutagenic factors are supposed to make a group of potentially increased risk of cancer.
Vorobtsova
I E
IE
Vorob'eva
M V
MV
Korytova
L I
LI
Shust
V F
VF
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D003131:Combined Modality Therapy; D005220:Fathers; D005260:Female; D015894:Genome, Human; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011878:Radiotherapy / Q000009:adverse effects*; D012044:Regression Analysis
D000970:Antineoplastic Agents
Issledovanie tsitogeneticheskoĭ reaktsii limfotsitov na obluchenie in vitro u deteĭ, rozhdennykh patsientami posle protivoopukholevoĭ luchevoĭ i khimioterapii.