Effects of clomiphene citrate stimulation on endometrial structure in infertile women.
Investigations into the effect of clomiphene citrate stimulation on endometrial differentiation were retrospectively performed in the mid-luteal phase on 21 patients undergoing ovulation induction prior to artificial insemination. A high incidence of irregular endometrial development was seen using morphological and morphometric criteria; in addition, increasing stromal oedema after clomiphene citrate treatment was observed. Measurable differences in glandular development (i.e. numbers of glands and glandular epithelial height) were found in early luteal phase biopsies (LH+2/+6) from patients treated with clomiphene citrate and normal fertile controls. Impaired endometrial development in the early luteal phase, which is a sensitive interval in preparation for implantation, might lead to an effective asynchrony between embryonic and uterine development and unfavourably influence the outcome of implantation.
Bonhoff
A J
AJ
Institute of Hormone and Fertility Research, University of Hamburg, Germany.
Naether
O G
OG
Johannisson
E
E
D000328:Adult; D002454:Cell Differentiation / Q000187:drug effects; D002996:Clomiphene / Q000627:therapeutic use*; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005300:Fertility Agents, Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000473:pathology* / Q000628:therapy
D005300:Fertility Agents, Female; D002996:Clomiphene