title: Synthesis and antiplatelet activity of 1-tert-butylamino-3-(3-thienyloxy)-2-propanols.
abstract: The synthesis of new 1-tert-butylamino-3-(3-thienyloxy)-2-propanols by two alternative methods is described. Their initial antiplatelet activity evaluation against ADP, adrenaline, and collagen is reported, and the preliminary structure-activity relationships are established. The appropriateness of further pharmacological investigations, especially for the best compound of the series 1f, is indicated.
authors.affiliation: Deparmento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Abdallah
authors.forename: V
authors.initials: V
authors.lastname: Darias
authors.forename: R
authors.initials: R
authors.lastname: Donoso
authors.forename: P
authors.initials: P
authors.lastname: Jordán de Urríes
authors.forename: J
authors.initials: J
authors.lastname: Lissavetzky
mesh_terms: D000433:1-Propanol / Q000138:chemical synthesis / Q000494:pharmacology*; D000328:Adult; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D020005:Propanols; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; D020005:Propanols; D000433:1-Propanol