[Reactive oxygen species and homeostasis].
Oxygen represents an important reactant which plays both positive and negative role in the metabolism. The deleterious effects are caused by the reactivity of substances originating in the partial reductions of their molecules. Therefore in the course of evolution many antioxidant systems have been developed, both enzymic and non-enzymic. The present review describes individual reactive oxygen species and the way of their detoxication in the organism. An important feature of antioxidant defence is its compartmentalization and cooperation between individual antioxidant systems which are described also with respect to their genetic encoding. For comparison properties of some artificial widely-used antioxidants are shown and their biological effects are discussed.
Wilhelm
J
J
Ustav lékarské chemie a biochemie 2. LF UK, Praha.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species; D002374:Catalase; D013482:Superoxide Dismutase
Reaktivní slouceniny kyslíku a homeostáza.