title: Alteration of interleukin-1 alpha production and interleukin-1 alpha binding sites in mouse brain during rabies infection.
abstract: We have evaluated the effect of rabies virus infection on interleukin-1 alpha (IL-1 alpha) production and its receptors in mouse brain. Study of virus dissemination in the central nervous system (CNS) showed a massive infection of main brain structures from day 4 post infection (p.i.) up to the agony stage on day 6 p.i. At the same time, IL-1 alpha concentrations increased in cortical and hippocampal homogenates, whereas no change was detected in serum. In non-infected mice, IL-1 alpha binding sites were observed in the dentate gyrus, the cortex, the choroid plexus, the meninges and the anterior pituitary. During rabies virus infection, a striking decrease in IL-1 alpha binding sites was observed on day 4 p.i. with a complete disappearance on day 6 p.i., except in the pituitary gland where they remained at control level. In conclusion, concomitantly with the early rabid pathological signs, brain IL-1 alpha production and IL-1 alpha binding sites are specifically and significantly altered by brain viral proliferation. These results indicate that IL-1 alpha could be involved in the brain response to viral infection as a mediator and could participate in the genesis of the rabies pathogeny.
authors.affiliation: Rabies Unit, Pasteur Institute, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Marquette
authors.forename: P E
authors.initials: PE
authors.lastname: Ceccaldi
authors.forename: E
authors.initials: E
authors.lastname: Ban
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Tsiang
authors.forename: F
authors.initials: F
authors.lastname: Haour
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D002540:Cerebral Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011818:Rabies / Q000378:metabolism*; D011820:Rabies virus / Q000502:physiology; D017472:Receptors, Interleukin-1 / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D007375:Interleukin-1; D017472:Receptors, Interleukin-1