title: Primary metastatic carcinoma of the prostate in younger men: a plea to think over usual therapeutic strategies.
abstract: METHODS
  The time from first diagnosis of primary multiple metastatic prostate carcinoma until progression and until death in patients less than 60 years old under two different therapeutic regimens was evaluated.
  
  
  RESULTS
  In the group with pure androgen deprivation (n = 21), the mean time until progression was 11.3 (6-55) months, the mean survival time being 21.4 (11-75) months. In the group with androgen deprivation plus cytostatic therapy (n = 10), progression was noted after 26.7 (15-77) months with a medium survival time of 26.2 (16-82) months.
  
  
  CONCLUSIONS
  The data argue in favor of changing the usual treatment strategy to combination therapy in "young' patients with primary metastatic prostatic cancer.
authors.affiliation: Department of Urology, University of Vienna Medical School, Austria.
authors.forename: U
authors.initials: U
authors.lastname: Maier
authors.forename: K
authors.initials: K
authors.lastname: Höbarth
authors.forename: R
authors.initials: R
authors.lastname: Simak
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D002369:Castration; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D004961:Estramustine / Q000008:administration & dosage / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use; D017408:Guidelines as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D014944:World Health Organization
chemical_list: D000728:Androgens; D000970:Antineoplastic Agents; D007987:Gonadotropin-Releasing Hormone; D004961:Estramustine; D004317:Doxorubicin; D002945:Cisplatin