title: The effect of intracervical vasopressin on the systemic absorption of glycine during hysteroscopic endometrial ablation.
abstract: OBJECTIVE
  To examine the effect of paracervical injection of vasopressin on the absorption of glycine during transcervical endometrial ablation.
  
  
  METHODS
  Thirty-three consecutive women scheduled for elective hysteroscopic endometrial ablation were randomized to either the study or control group. All procedures were performed with a myoma resectoscopy using 1.5% glycine as the irrigating medium at a flow rate of 100 mL/minute. In the study group, a solution of 0.2 mg vasopressin diluted with 20 mL saline was injected paracervically. Blood samples were obtained through an indwelling intravenous catheter every 5 minutes until the completion of the operation. Serum sodium, potassium, and magnesium levels were measured at 20-minute intervals. In addition, glycine concentrations were determined by both rapid screening and quantitative amino acid analysis.
  
  
  RESULTS
  Plasma glycine maximal concentrations were significantly lower (P < .001) in patients who received vasopressin, compared with controls (8.8 +/- 4.5 versus 16.0 +/- 6.3 mmol/L, respectively). The calculated extent of glycine absorption within the first 20 minutes of the procedure was 59.6 +/- 30.0 versus 179.8 +/- 66.2 mmol/L.minute in the study and control groups, respectively (P < .001). The differences in plasma sodium, potassium, and magnesium levels were not significant.
  
  
  CONCLUSIONS
  Intracervical vasopressin administration significantly decreased systemic glycine absorption in patients undergoing hysteroscopic endometrial ablation.
authors.affiliation: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Goldenberg
authors.forename: M
authors.initials: M
authors.lastname: Zolti
authors.forename: D
authors.initials: D
authors.lastname: Bider
authors.forename: A
authors.initials: A
authors.lastname: Etchin
authors.forename: B A
authors.initials: BA
authors.lastname: Sela
authors.forename: D S
authors.initials: DS
authors.lastname: Seidman
mesh_terms: D000042:Absorption; D000328:Adult; D002584:Cervix Uteri; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005998:Glycine / Q000493:pharmacokinetics*; D006801:Humans; D015907:Hysteroscopy; D007267:Injections; D008274:Magnesium / Q000097:blood; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D007507:Therapeutic Irrigation; D014592:Uterine Hemorrhage / Q000601:surgery*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage* / Q000494:pharmacology; D014667:Vasopressins / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D005998:Glycine