title: Synthesis and antitumor activity of some analogues of flavone acetic acid.
abstract: Some coumarin-, flavonol- and flavanon-acetic acids are described. The cytotoxicity of the synthesized compounds was determined on a human colon carcinoma cell line (LoVo) through evaluation of neutral red uptake, performed by the Riddel method. All tested derivatives were able to induce a statistically significant reduction of lysosomal neutral red uptake at 5 x 10(-5) M concentration. Some compounds were more active than the reference compound flavon-8-acetic acid.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Valenti
authors.forename: G
authors.initials: G
authors.lastname: Fabbri
authors.forename: A
authors.initials: A
authors.lastname: Rampa
authors.forename: A
authors.initials: A
authors.lastname: Bisi
authors.forename: S
authors.initials: S
authors.lastname: Gobbi
authors.forename: P
authors.initials: P
authors.lastname: Da Re
authors.forename: M
authors.initials: M
authors.lastname: Carrara
authors.forename: A
authors.initials: A
authors.lastname: Sgevano
authors.forename: L
authors.initials: L
authors.lastname: Cima
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003374:Coumarins / Q000138:chemical synthesis / Q000627:therapeutic use; D005419:Flavonoids / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000085:Acetates; D000970:Antineoplastic Agents; D003374:Coumarins; D005419:Flavonoids