title: Correlation between the progression of optic disc and visual field changes in glaucoma.
abstract: Visual field test and optic disc evaluation are the standard examination techniques used to detect the onset and progression of glaucoma. This explorative study was performed to assess the temporal correlation between visual field and optic disc changes in eyes with ocular hypertension and well-established glaucoma. Eighty-six hypertensive and 16 glaucomatous eyes were followed up for a period of up to 9 years (average 4.4 yrs) using kinetic and computerized static perimetry and optic disc manual morphometry. Perimetric changes were based on a series of strict criteria and optic disc changes were based as a reduction in the baseline rim area/disc area ratio (R/D) measurement exceeding the 99% confidence interval for intraobserver reproducibility (7.7%). Optic disc changes were found prior to visual field changes in four hypertensive eyes, whereas visual field changes were found prior to disc changes in six glaucomatous eyes (p = 0.042). The results of our explorative study suggest that quantitative optic disc analysis may be more sensitive than visual field examination in detecting early glaucomatous changes, whereas visual field examination may be more sensitive than quantitative optic disc analysis in detecting glaucomatous progressions in eyes with well established glaucoma.
authors.affiliation: Department of Ophthalmology, University of Milan, S. Paolo Hospital, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Miglior
authors.forename: L
authors.initials: L
authors.lastname: Brigatti
authors.forename: C
authors.initials: C
authors.lastname: Lonati
authors.forename: L
authors.initials: L
authors.lastname: Rossetti
authors.forename: C
authors.initials: C
authors.lastname: Pierrottet
authors.forename: N
authors.initials: N
authors.lastname: Orzalesi
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000473:pathology / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D014794:Visual Fields