title: New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system.
abstract: Drosophila is an ideal system for identifying genes that control central nervous system (CNS) development. Particularly useful tools include molecular markers for subsets of neural precursors (neuroblasts) and the simple expression pattern of the even-skipped (eve) gene in a subset of neurons. Here we provide additional molecular markers for identified neuroblasts, including several with near single cell specificity. In addition, we use these new markers to trace the development of several eve+ neurons. Our results shows that the eve+ aCC/pCC neurons develop from a different neuroblast than previously thought, and have led us to assign new names for several neuroblasts. These results are supported by DiI cell lineage analysis of neuroblasts identified in vivo.
authors.affiliation: Neuroscience Program, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA.
authors.forename: J
authors.initials: J
authors.lastname: Broadus
authors.forename: J B
authors.initials: JB
authors.lastname: Skeath
authors.forename: E P
authors.initials: EP
authors.lastname: Spana
authors.forename: T
authors.initials: T
authors.lastname: Bossing
authors.forename: G
authors.initials: G
authors.lastname: Technau
authors.forename: C Q
authors.initials: CQ
authors.lastname: Doe
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D017344:Genes, Insect; D005819:Genetic Markers; D009474:Neurons / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism
chemical_list: D005819:Genetic Markers