[Changes in biological and physico-chemical properties of avian influenza virus A hemagglutinin H2 during adaptation to a new host].
Avian influenza A virus with H2 hemagglutinin has been adapted to mice for the first time. Alterations in the hemagglutinin of adapted variants of the virus as a result of adaptation to a new host are described. Hemagglutinin of a highly virulent adapted variant differed from the parental avirulent strain by antigenic structure, electrophoretic mobility, and receptor activity during interactions with murine red cells.
Lipatov
A S
AS
Gitel'man
A K
AK
Govorkova
E A
EA
Smirnov
Iu A
IuA
D000222:Adaptation, Physiological; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004285:Dogs; D004912:Erythrocytes / Q000821:virology; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000378:metabolism*; D009980:Influenza A virus / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D007928:Lethal Dose 50; D051379:Mice
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral
Izmeneniia biologicheskikh i fiziko-khimicheskikh svoĭstv gemaggliutinina H2 ptich'ego virusa grippa A v protsesse adaptatsii k novomu khozainu.