After-cataract formation in newborn rabbits implanted with intraocular lenses.
OBJECTIVE
Comparison of the after-cataract formation in newborn rabbits implanted with a heparin-surface-modified (HSM) intraocular lens (IOL), a silicone IOL, or no IOL.


METHODS
Two groups of 3-week-old rabbits were used. In Group 1 (n = 11), lensectomy was performed in both eyes. One eye was selected at random and an HSM IOL was implanted in the capsular bag; the other eye was left aphakic. In Group 2 (n = 13), lensectomy was performed in both eyes. An HSM IOL was implanted in one eye, a silicone IOL in the other. The wet mass of the dissected after-cataract was determined 3 months after surgery in both groups.


RESULTS
In Group 1, the wet mass of the dissected after-cataract was 17.0 +/- 6.5 mg (mean +/- SEM) in eyes implanted with an HSM IOL and 159.7 +/- 17.0 mg in aphakic eyes. This difference was statistically significant (P < .01). In Group 2, the wet mass of the dissected after-cataract was 18.3 +/- 4.3 mg in eyes implanted with an HSM IOL and 25.7 +/- 5.2 mg in eyes implanted with a silicone IOL. No statistically significant difference was found.


CONCLUSIONS
In young rabbits, implantation of an IOL in the capsular bag following lensectomy reduced cell proliferation.
Zetterström
C
C
Department of Ophthalmology, S:t Erik Eye Hospital, Stockholm, Sweden.
Kugelberg
U
U
Lundgren
B
B
Syrén-Nordqvist
S
S
D000818:Animals; D000831:Animals, Newborn; D002386:Cataract / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D006493:Heparin; D007903:Lens Capsule, Crystalline / Q000473:pathology; D007910:Lenses, Intraocular; D011183:Postoperative Complications / Q000473:pathology*; D011817:Rabbits; D012828:Silicones; D013499:Surface Properties
D012828:Silicones; D006493:Heparin