title: Acute surgical treatment of complicated peptic ulcers with special reference to the elderly.
abstract: The results of 136 consecutive patients treated surgically for the acute complications of peptic ulcers between 1990 and 1993 are reviewed. All patients required emergency operation. Among 136 patients, 91 had perforations, 42 hemorrhage, and 3 a penetrated peptic ulcer. The median age was 77 years; 65% were women; and 83% were more than 60 years old. Concurrent disease requiring medical treatment were present in 92 patients; 79 patients (58%) were currently or recently taking antiinflammatory drugs at the time of admission; 66% of the patients had duodenal ulcer. Only 46 patients (34%) had no postoperative complications; pneumonia, arrhythmia, bleeding, and septic complications were the most frequent. The overall mortality was 30%. Sepsis and multiple organ failure was the leading cause of death in most of the patients. It was concluded that elderly individuals using two or more antiinflammatory drugs should be considered potential peptic ulcer patients and should be treated prophylactically with ulcer-healing drugs.
authors.affiliation: Department of Gastrointestinal Surgery, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
authors.forename: O B
authors.initials: OB
authors.lastname: Bulut
authors.forename: C
authors.initials: C
authors.lastname: Rasmussen
authors.forename: A
authors.initials: A
authors.lastname: Fischer
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D004630:Emergencies; D005260:Female; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000150:complications* / Q000601:surgery*; D010438:Peptic Ulcer Hemorrhage / Q000601:surgery; D010439:Peptic Ulcer Perforation / Q000601:surgery; D011183:Postoperative Complications / Q000401:mortality