title: A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency.
abstract: A large scale cytogenetic study of the radiation damage in nuclear power plant workers and medical workers handling X-ray machines (269 individuals) was undertaken using the micronucleus assay for peripheral blood lymphocytes. The micronucleus frequency was found to increase systematically with donor age. After correction for the age-dependence, no correlation of the micronucleus frequency with smoking habits, expressed as cigarette-years and cigarette consumption per day, could be observed. Compared to the group of administrative workers receiving doses below 1 mSv/year, limit recommended by the ICRP for public exposure, the micronucleus frequency was slightly increased in the group of radiation workers, exposed occupationally. However, applying the Mann-Whitney test, the observed differences are not statistically significant. After correction of the dose accumulation pattern for the turn-over of the lymphocyte pool, a weak correlation between the micronucleus frequency and the equivalent dose accumulated over the 10 years preceding the study was obtained. For clear-cut conclusions on the radiation damage of low-dose worker cohorts, an increase in the sensitivity of the assay, e.g., by analysis of the micronuclei for the presence of centromeres is necessary.
authors.affiliation: Department of Biomedical Physics, University Gent, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Thierens
authors.forename: A
authors.initials: A
authors.lastname: Vral
authors.forename: L
authors.initials: L
authors.lastname: De Ridder
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics*; D001822:Body Burden; D002869:Chromosome Aberrations; D006801:Humans; D015162:Micronucleus Tests; D016273:Occupational Exposure; D011832:Radiation Injuries / Q000235:genetics*; D012907:Smoking / Q000235:genetics*