Characterization of an acquired IgG inhibitor of coagulation factor XIII in a patient with systemic lupus erythematosus.
An acquired IgG inhibitor to factor XIII was identified in a 30-year-old Vietnamese woman with systemic lupus erythematosus. The IgG fraction was isolated from plasma by chromatography on an agarose gel column and by protein G adsorption. The anti-factor XIII activity, identified within the IgG fraction, inhibited factor XIII from both normal plasma (a2b2) and platelets (a2). A normal level of the b subunit was measured by immunoelectrophoresis of the patient's plasma, but the a subunit was not detected. These results suggested the presence of an IgG immunoglobulin which recognized the a subunit and interfered with its activity.
Ahmad
F
F
Division of Cardiology, Royal Victoria Hospital, McGill University, Montreal, Canada.
Solymoss
S
S
Poon
M C
MC
Berube
C
C
Sullivan
A K
AK
D000328:Adult; D005176:Factor XIII / Q000037:antagonists & inhibitors*; D005177:Factor XIII Deficiency / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000378:metabolism
C029152:G-substrate; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins; D005176:Factor XIII