title: 2-Diazopyrroles: synthesis and antileukemic activity.
abstract: The title compounds were synthesised in preparative yields by diazotization of the corresponding 2-aminopyrroles. In preliminary screening tests as antileukemic agents they showed modest activity against the murine and human leukemic cell lines FLC and K562S and their multidrug-resistant daunorubicin selected sublines.
authors.affiliation: Istituto Farmacochimico, Università di Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cirrincione
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: S
authors.initials: S
authors.lastname: Grimaudo
authors.forename: P
authors.initials: P
authors.lastname: Barraja
authors.forename: G
authors.initials: G
authors.lastname: Dattolo
authors.forename: E
authors.initials: E
authors.lastname: Aiello
authors.forename: F
authors.initials: F
authors.lastname: Mingola
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011758:Pyrroles