title: [Reduction of cardiovascular events with pravastatin. A pooled analysis of clinical events within the scope of the Pravastatin Atherosclerosis Intervention Program].
abstract: BACKGROUND
  It has been documented that the HMG coenzyme A reductase inhibitors, or statins, can decrease cardiovascular events and mortality in patients with clinical coronary disease and moderately to severely elevated lipid levels. Additional data are required to demonstrate a reduction of vascular events in coronary patients with less than severely elevated lipid levels and in subgroups of this population.
  
  
  RESULTS
  Clinical data from four atherosclerosis regression trials that evaluated pravastatin were pooled for a predetermined analysis of the effect of that agent on the risk of coronary events. All trials were double-masked, placebo-controlled designs that used pravastatin as monotherapy for 2 to 3 years. The 1891 participants in the trials had evidence of atherosclerosis and mildly to moderately elevated lipid levels. For fatal or nonfatal myocardial infarction, there was a 62% reduction in events attributable to pravastatin (p = .001). This effect was evident in younger and older patients, men and women, and patients with and without histories of hypertension and prior infarction. There was a 46% reduction in all-cause mortality (p = 17), which, although not statistically significant, is consistent with the results of other statin trials. There also was a 62% reduction in the risk of fatal or nonfatal stroke (p = .054).
  
  
  CONCLUSIONS
  These pooled results provide strong evidence that pravastatin reduces the risk of cardiovascular events in patients with atherosclerotic disease and mildly to moderately elevated lipid levels. The benefit for reducing myocardial infarction is evident in older and younger patients, men and women, and patients with and without histories of hypertension and prior infarction.
authors.affiliation: Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Byington
authors.forename: J W
authors.initials: JW
authors.lastname: Jukema
authors.forename: J T
authors.initials: JT
authors.lastname: Salonen
authors.forename: B
authors.initials: B
authors.lastname: Pitt
authors.forename: A V
authors.initials: AV
authors.lastname: Bruschke
authors.forename: H
authors.initials: H
authors.lastname: Hoen
authors.forename: C D
authors.initials: CD
authors.lastname: Furberg
authors.forename: G B
authors.initials: GB
authors.lastname: Mancini
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000401:mortality; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D017035:Pravastatin / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin
vernacular_title: Reduktion kardiovaskulärer Ereignisse unter Pravastatin. Eine gepoolte Analyse klinischer Ereignisse im Rahmen des Pravastatin-Atherosklerose-Interventions-Programms.