NADPH-diaphorase-positive neurons in primate cerebral cortex colocalize with GABA and calcium-binding proteins.
Neurons in the monkey cerebral cortex containing nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) can be divided into two distinct types, both nonpyramidal. Type I neurons have a large soma (diameter 20-50 microm), a dense NADPH-d histochemical reaction, and are distributed throughout the cortex, but mainly in the subcortical white matter, and are mostly aspiny. Type II cells have a small soma ( Together with previous observations that almost all cortical NADPH-d cells in various subprimates are like type I cells, we suggest that type II cells may form a group of NADPH-d-rich neurons differentiated in higher mammalian cortex from a subpopulation of calbindin-containing GABAergic interneurons, and these nitric oxide-synthesizing cells may play a role in control of intracortical neuronal activity characteristic of higher cerebral functions in advanced mammals.
Yan
X X
XX
Department of Anatomy and Neurobiology, Hunan Medical University, Changsha, Hunan 410078, China.
Jen
L S
LS
Garey
L J
LJ
D000818:Animals; D064026:Calbindins; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D007150:Immunohistochemistry; D008252:Macaca fascicularis; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology*; D010320:Parvalbumins / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D064026:Calbindins; D002135:Calcium-Binding Proteins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D005680:gamma-Aminobutyric Acid; D009252:NADPH Dehydrogenase