[The mechanism of induction and expression of protective immunity with special reference to the role of cytokines].
The mechanism of induction of protective T cells mediating the anti-tuberculous immunity is not well elucidated. Using viable and killed cells of Mycobacterium bovis BCG and Listeria monocytogenes, which differ in the ability to induce specific protection in mice, we have found that the difference is mainly due to the different ability to induce several cytokines especially IFN-rho not due to the difference in antigenic property. It was shown that the induction of protective T cells is highly dependent upon various cytokines produced by the host at the early stage of immunization. Based on our own experimental result in mice, the relative contribution of several cytokines to the induction and expression of cell-mediated immune protection was discussed.
Mitsuyama
M
M
Department of Bacteriology, Niigata University School of Medicine, Japan.
D000818:Animals; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D008089:Listeria monocytogenes / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology*
D016207:Cytokines