title: The P-450 system. Definition and relevance to the use of antidepressants in medical practice.
abstract: Over the last several years, several new antidepressants have been introduced into primary care practice. A number of these, including the selective serotonin reuptake inhibitors and nefazodone, have some common and potentially significant drug interactions as a result of interference with components of the hepatic P-450 enzyme system. This review provides information on those drugs that interfere with P-450 function (inhibitors), as well as those substrates whose metabolism can be impaired by P-450 inhibitors. Because it is important for primary care clinicians to be aware of these interactions, this article presents a review of the P-450 system and its relevance to the use of antidepressants in medical practice.
authors.affiliation: Department of Medicine, Brown University, Providence, RI, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Goldberg
mesh_terms: D000367:Age Factors; D000928:Antidepressive Agents / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans
chemical_list: D000928:Antidepressive Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System