title: Laparotomy and proximal gastric vagotomy in Zollinger-Ellison syndrome: results of a 16-year prospective study.
abstract: OBJECTIVE
  Pharmacological control of gastric acid hypersecretion in the Zollinger-Ellison syndrome has steadily improved, but medical treatment does not address the underlying tumor. The objective of this study was to evaluate the long-term effectiveness of a surgical approach to both tumor and acid hypersecretion in 22 patients with the Zollinger-Ellison syndrome.
  
  
  METHODS
  Patients underwent laparotomy to resect tumors, combined with vagotomy to reduce acid secretion, followed by postoperative antisecretory therapy, if necessary.
  
  
  RESULTS
  No surgical mortality or serious morbidity occurred. Tumor was found at laparotomy in nine patients (41%) and during long-term follow-up in an additional two patients (9%). Ten-year survival is 81%, with a long-term cure rate of at least 14%. Most patients (86%) have had long-term inhibition of acid secretion. Eight patients have discontinued regular use of acid-inhibiting medications. Patients requiring medication need less of it, and they have an improved acid inhibitory response to medication for up to 16 yr after surgery.
  
  
  CONCLUSIONS
  Cure of the Zollinger-Ellison syndrome is possible in a minority of patients. Acid secretion can be safely reduced in almost all patients with laparotomy/vagotomy, usually allowing discontinuation, or reduced dose, of acid-inhibiting drugs. Long-term survival and quality of life are generally excellent.
authors.affiliation: Medical Service, Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: McArthur
authors.forename: C T
authors.initials: CT
authors.lastname: Richardson
authors.forename: C C
authors.initials: CC
authors.lastname: Barnett
authors.forename: N
authors.initials: N
authors.lastname: Eshaghi
authors.forename: M J
authors.initials: MJ
authors.lastname: Smerud
authors.forename: R N
authors.initials: RN
authors.lastname: McClelland
authors.forename: M
authors.initials: M
authors.lastname: Feldman
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D015408:Gastrinoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D006801:Humans; D007813:Laparotomy; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013781:Texas / Q000453:epidemiology; D014629:Vagotomy, Proximal Gastric; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*