title: Synovial fluid and serum antibodies against Chlamydia in different forms of arthritis: intra-articular IgA production in Chlamydia sexually acquired reactive arthritis.
abstract: Since the presence of Chlamydia has been shown in synovial fluid (SF) from some patients with Chlamydia reactive arthritis, we investigated whether anti-Chlamydia antibodies present in the joint are derived from the circulation or are locally produced. We compared titres of IgG, IgM and IgA antibodies against Chlamydia, and against a control antigen (tetanus toxoid), by an enzyme-linked immunosorbent assay (ELISA), in paired samples of serum and SF from Chlamydia trachomatis sexually acquired reactive arthritis (CT-SARA) patients and from patients with other forms of arthritis. The ratio of serum/SF IgA anti-Chlamydia antibodies was significantly decreased in CT-SARA patients. It is concluded that, in our experimental conditions, we found evidence for intra-articular production of IgA anti-Chlamydia antibodies.
authors.affiliation: Division of Rheumatology, University Hospital, Geneva, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Bas
authors.forename: T
authors.initials: T
authors.lastname: Cunningham
authors.forename: T K
authors.initials: TK
authors.lastname: Kvien
authors.forename: A
authors.initials: A
authors.lastname: Glennås
authors.forename: K
authors.initials: K
authors.lastname: Melby
authors.forename: T L
authors.initials: TL
authors.lastname: Vischer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000097:blood; D001168:Arthritis / Q000276:immunology; D016918:Arthritis, Reactive / Q000276:immunology*; D002689:Chlamydia / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007132:Immunoglobulin Isotypes / Q000032:analysis* / Q000097:blood; D008875:Middle Aged; D013582:Synovial Fluid / Q000276:immunology* / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes