MODS/SIRS: result of an overwhelming inflammatory response?
Multiple organ dysfunction syndrome and the systemic inflammatory response syndrome are expressions of an inappropriate, generalized inflammatory response to severe inflammatory stimuli, which may be bacterial or nonbacterial in nature. The clinical signs and symptoms, morphologic alterations, and changes in oxygen transport seem to be the direct effect of phagocyte activation. So far, identifying the microorganisms and neutralizing their toxins has not been helpful in improving prognosis. As an essential adjunct to treating the bacterial or nonbacterial causes, finding safe ways of modulating the phagocyte response should be considered.
Goris
R J
RJ
Department of Surgery, University Hospital Nijmegen, 6500 HB Nijmegen, The Netherlands.
D000818:Animals; D004731:Endotoxins / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D009102:Multiple Organ Failure / Q000503:physiopathology* / Q000628:therapy; D010100:Oxygen / Q000502:physiology; D010587:Phagocytosis / Q000502:physiology; D011379:Prognosis; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology* / Q000628:therapy
D004731:Endotoxins; D018836:Inflammation Mediators; D010100:Oxygen