Analysis of cross-over trials for duration data.
Survival models and cross-over designs both have an established place in biomedical research. Surprisingly, there are a few examples of proper exploitation of two in combination. A number of advantages and disadvantages of such studies are discussed. Two examples are used to illustrate the application of semi-Markov models with time-varying covariates, as standard log-linear models, to such data.
Lindsey
J K
JK
Department of Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium.
Jones
B
B
Lewis
J A
JA
D018592:Cross-Over Studies; D016014:Linear Models; D008390:Markov Chains; D015233:Models, Statistical; D016016:Proportional Hazards Models; D016019:Survival Analysis