The relationship between weight loss and interleukin 6 in non-small-cell lung cancer.
Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.
Scott
H R
HR
Department of Respiratory Medicine, Stobhill NHS Trust, Glasgow, UK.
McMillan
D C
DC
Crilly
A
A
McArdle
C S
CS
Milroy
R
R
D000210:Acute-Phase Reaction / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015431:Weight Loss / Q000502:physiology*
D015850:Interleukin-6