Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles.
Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.
Allémann
E
E
School of Pharmacy, University of Geneva, Switzerland.
Rousseau
J
J
Brasseur
N
N
Kudrevich
S V
SV
Lewis
K
K
van Lier
J E
JE
D000818:Animals; D001673:Biodegradation, Environmental; D004396:Coloring Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D004337:Drug Carriers; D004655:Emulsions; D005990:Glycerol / Q000031:analogs & derivatives; D007211:Indoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010316:Particle Size; D010778:Photochemotherapy; D011091:Polyesters; D011092:Polyethylene Glycols; D011108:Polymers; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012995:Solubility; D013535:Suspensions; D013848:Thigh; D014407:Tumor Cells, Cultured
D004396:Coloring Agents; D004337:Drug Carriers; D004655:Emulsions; D007211:Indoles; D007773:Lactates; D009942:Organometallic Compounds; D011091:Polyesters; D011108:Polymers; D011838:Radiation-Sensitizing Agents; D013535:Suspensions; C097030:hexadecafluoro zinc phthalocyanine; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); C000515:cremophor EL; D005990:Glycerol