Aberrant B cell development and immune response in mice with a compromised BCR complex.
The immunoglobulin alpha (Ig-alpha)-Ig-beta heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-alpha cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop demonstrate a differential dependence on Ig-alpha signaling in antibody responses such that a signaling-competent Ig-alpha appears to be critical for the response to T-independent, but not T-dependent, antigens.
Torres
R M
RM
Institute for Genetics, University of Cologne, Germany.
Flaswinkel
H
H
Reth
M
M
Rajewsky
K
K
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D015703:Antigens, CD / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D000955:Antigens, T-Independent / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D001854:Bone Marrow Cells; D051925:CD79 Antigens; D019070:Cell Lineage; D015322:Gene Rearrangement, B-Lymphocyte; D018390:Gene Targeting; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction
D000941:Antigens; D015703:Antigens, CD; D000955:Antigens, T-Independent; D051925:CD79 Antigens; C497882:Cd79a protein, mouse; C497884:Cd79b protein, mouse; D011947:Receptors, Antigen, B-Cell