Verbal autopsy as a tool for diagnosing HIV-related adult deaths in rural Uganda.
BACKGROUND
In general, information on the causes of adult deaths in developing countries is scarce. More specifically, relatively little is known about the effect of HIV-1 associated disease on adult mortality in general populations. In this study we have used a verbal autopsy technique to ascertain whether adult deaths were associated with HIV-1 in a rural population with a prevalence of HIV-1 infection of 8%, and used HIV-1 antibody status to validate the verbal autopsy findings.


METHODS
All adult deaths in the population cohort that occurred between December 1990 and November 1993 were identified through a monthly death registration system. Approximately 2 months after death, a relative of the deceased was interviewed by a trained nurse, and questionnaires were assessed by at least two independent clinicians; all were unaware of the HIV serostatus of the deceased.


RESULTS
A total of 155 adult deaths was assessed, i.e. 53% of all recorded adult deaths. Of those assessed half were HIV-1 positive. In all 47% of deaths were classified as HIV-related. The overall specificity and positive predictive value of the verbal autopsy tool were both 92%; in those aged 13-44 years (83 adults) the corresponding values were 85% and 95% respectively. The verbal autopsy estimated HIV-1 attributable mortality fraction was similar to the calculated fraction based on prospective data.


CONCLUSIONS
The results of this study suggest that verbal autopsy studies may assist in providing data on HIV-associated mortality in general populations and may be useful as surveillance tools.
Kamali
A
A
Medical Research council (UK) Programme on AIDS in Uganda, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda.
Wagner
H U
HU
Nakiyingi
J
J
Sabiiti
I
I
Kengeya-Kayondo
J F
JF
Mulder
D W
DW
D000293:Adolescent; D000328:Adult; D002423:Cause of Death; D015658:HIV Infections / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D007407:Interviews as Topic / Q000379:methods*; D012424:Rural Population; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D014454:Uganda / Q000453:epidemiology