title: Detection of nontraumatic comatose patients with no benefit of intensive care treatment by recording of sensory evoked potentials.
abstract: OBJECTIVE
  To determine the predictive ability of sensory evoked potential recordings in nontraumatic comatose patients. To evaluate the hypothesis that patients with bilateral absent cortical responses ultimately die despite long-term intensive care treatment.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Medical intensive care unit (ICU) of a university hospital.
  
  
  METHODS
  Four hundred forty-one adult nontraumatic comatose patients (unarousable unresponsiveness to external stimulation, Glasgow Coma Score < or = 7) from various causes. Six hundred seventy-six sensory evoked potential measurements were performed within 7 days after onset of coma.
  
  
  METHODS
  Death or survival to hospital discharge.
  
  
  RESULTS
  Eighty-six patients (20%) had a bilateral loss of the cortical evoked potential N20 peak. Despite long-term intensive care treatment, all died without awakening from coma (mortality rate, 100%; 95% confidence interval, 96-100). The mean stay at the ICU after evoked potential measurement until death was 8.1 days (697 patient days). The overall cost of ICU management for these 86 patients accounted for approximately $1,324,300. In the remaining 355 comatose patients with preserved cortical N20 peak, 148 (42%) survived and 207 (58%) died. In this latter group of patients, cervicomedullary N13 to cortical N20 conduction time was prolonged in nonsurvivors (mean +/- SD, 6.7 +/- 1.3 milliseconds) compared with that in survivors (mean +/- SD, 6.4 +/- 1.2 milliseconds, P < .05) and healthy controls (mean +/- SD, 5.5 +/- 0.4 milliseconds, P < .05). Although this difference is statistically significant, a preserved N20 peak is not useful to discriminate whether the individual patient will survive (N13-N20 conduction time of > 7 milliseconds had a positive predictive value of correct prediction of death of 0.67).
  
  
  CONCLUSIONS
  Recording of sensory evoked potentials identifies a subgroup of adult nontraumatic comatose patients with a mortality rate of 100% in our sample. In these patients, advanced intensive care treatment should be withdrawn to provide limited ICU resources for patients with higher probability of favorable outcome. We emphasize that these results are not applicable to comatose patients following closed head trauma and particularly not to children.
authors.affiliation: Department of Medicine IV, University Hospital of Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Madl
authors.forename: L
authors.initials: L
authors.lastname: Kramer
authors.forename: W
authors.initials: W
authors.lastname: Yeganehfar
authors.forename: E
authors.initials: E
authors.lastname: Eisenhuber
authors.forename: A
authors.initials: A
authors.lastname: Kranz
authors.forename: K
authors.initials: K
authors.lastname: Ratheiser
authors.forename: C
authors.initials: C
authors.lastname: Zauner
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Grimm
mesh_terms: D000293:Adolescent; D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003128:Coma / Q000401:mortality / Q000503:physiopathology*; D003422:Critical Care; D004558:Electric Stimulation; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008020:Life Support Care; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D018447:Medical Futility; D008875:Middle Aged; D011379:Prognosis; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D015996:Survival Rate