title: Relation between postoperative infections and gallbladder bile leakage during laparoscopic cholecystectomies.
abstract: BACKGROUND
  In 1,577 laparoscopic cholecystectomies, 111 due to acute and 1,466 due to chronic cholecystitis, the incidence of intraoperative gallbladder rupture and its relationship with abdominal wound infections were evaluated.
  
  
  METHODS
  A sampling test for binomial proportions and a binomial approximation test for discrete data were employed for statistical analysis. Gallbladder accidental opening took place in 250 (19%) out of the 1,466 chronic and in 44 (40%) out of the 111 acute cholecystitis, disclosing a statistically significant difference (p < 0.01). Postoperatively, there were 32 (2%) surgical wound infections, 17 (1.3%) in the absence of gallbladder injury and 15 (5%) when gallbladder injury was observed, likewise showing a statistically significant difference (p < 0.05).
  
  
  RESULTS
  It should be pointed out that all 32 wound infections involved the umbilical incision, of which 3 with chronic suppuration required reintervention where remnants of stones were found in the parietal route. The seven with symptomatic abdominal fluid resolved without specific treatment. As regards the seven intraabdominal infections, two remitted with antibiotics and five required percutaneous drainage. There was no significant correlation between the presence of cavity fluid abdominal collections or infections and bile spillage.
  
  
  CONCLUSIONS
  Gallbladder injury proved more frequent in laparoscopic cholecystectomies performed due to acute cholecystitis, while bile spillage increased the incidence of umbilical wound infection, particularly in the presence of remnants of stones, but there was no correlative increase in the incidence of intraabdominal collections or infections.
authors.affiliation: Department of Surgery, University Hospital, Buenos Aires University, Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Diez
authors.forename: C J
authors.initials: CJ
authors.lastname: Arozamena
authors.forename: P
authors.initials: P
authors.lastname: Ferraina
authors.forename: J M
authors.initials: JM
authors.lastname: Franci
authors.forename: A
authors.initials: A
authors.lastname: Ferreres
authors.forename: J M
authors.initials: JM
authors.lastname: Lardies
authors.forename: V P
authors.initials: VP
authors.lastname: Gutierrez
mesh_terms: D000208:Acute Disease; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D002764:Cholecystitis / Q000601:surgery; D002769:Cholelithiasis / Q000601:surgery; D002908:Chronic Disease; D005704:Gallbladder / Q000293:injuries*; D006801:Humans; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection