Clinical correlations with HLA type in Japanese patients with connective tissue disease and anti-U1 small nuclear RNP antibodies.
OBJECTIVE
To elucidate the roles of HLA genes in the clinical presentation of patients with connective tissue disease and serum anti-U1 small nuclear RNP antibody.


METHODS
HLA class I antigens and HLA class II alleles were determined in 43 Japanese patients with anti-U1 RNP antibody alone, by microcytotoxicity testing and DNA typing, respectively. Prospectively recorded clinical and laboratory features were analyzed in relation to HLA class I and class II types.


RESULTS
DQB1*0303 was associated with lupus-related symptoms including fever, malar rash, oral ulcers, hypocomplementemia, and high-titer anti-double-stranded DNA antibody. Other HLA-clinical associations included DR2 with pleuritis, DR4 with hand swelling, and DRB1*0405 with arthritis.


CONCLUSIONS
These HLA-clinical associations explain, in part, the heterogeneous clinical presentation in patients with anti-U1 RNP antibody.
Kuwana
M
M
Nippon Kokan Hospital, Kawasaki, Japan.
Okano
Y
Y
Kaburaki
J
J
Inoko
H
H
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000906:Antibodies; D002648:Child; D003240:Connective Tissue Diseases / Q000276:immunology*; D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000276:immunology*; D013223:Statistics as Topic
D000906:Antibodies; D006680:HLA Antigens; D017412:Ribonucleoprotein, U1 Small Nuclear