title: Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report.
abstract: In the United States and Western Europe, primary hepato-cellular carcinoma is an uncommon malignancy. Even though many well-defined associations have been reported, paraneoplastic manifestations are rare in North American patients. We describe an adolescent with complaints of weight loss, weakness, and a sensation of ¿fullness in the upper abdomen.¿ On initial laboratory workup a lactescent serum was found, with the following abnormalities; serum cholesterol level of 573 mg/dl (normal 120-260), triglycerides of 1,761 mg/dl (normal 10-190), and serum thyroxine level of 21 microgram/dl (normal 5.5-12.3). Serum albumin, calcium, and thyroid-stimulating hormone levels were also minimally elevated. Liver biopsy confirmed hepatocellular carcinoma. This is a rare hepatoma, which in our case manifested with multiple paraneoplastic phenomena, including hyperthyroxinemia, hypercholesterolemia, hypertriglyceridemia, and hyperalbuminemia. We review the pertinent literature.
authors.affiliation: Division of Gastroenterology, SUNY Health Science Center, Syracuse, New York 13210, USA.
authors.forename: R
authors.initials: R
authors.lastname: Nizam
authors.forename: F
authors.initials: F
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D006528:Carcinoma, Hepatocellular / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006981:Hyperthyroxinemia / Q000209:etiology*; D008055:Lipids / Q000097:blood*; D008113:Liver Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000150:complications*
chemical_list: D008055:Lipids