[Candidiasis of the liver following successful chemotherapy of acute myeloid leukemia (Fab type 6) and recovery with oral fluconazole therapy].
The spectrum of disseminated candidiasis includes both an acute and chronic presentation. In contrast to the acute form, chronic disseminated candidiasis (hepatosplenic candidiasis) often occurs late after granulocytopenic episodes in patients undergoing chemotherapy, usually for acute leukemia. We discuss a female patient who underwent extensive successful chemotherapy for acute myelogenous leukemia (FAB type 6) and who developed chronic hepatosplenic candidiasis 19 months later. Therapy with amphotericin B and flucytosine was not successful and a cure was effected only after long-term oral fluconazole treatment. Diagnostic problems, possible reasons for the observed failure of amphotericin B treatment, and the current use of fluconazole in disseminated candidiasis are discussed.
Keiser
G
G
Medizinische Klinik, Kantonsspital Zug.
Schmid
M
M
Ishak
K G
KG
Wirth
W
W
Vogt
M
M
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D008100:Liver Abscess / Q000382:microbiology*; D009894:Opportunistic Infections / Q000382:microbiology
D000935:Antifungal Agents; D007140:Immunoglobulin Fab Fragments; D015725:Fluconazole
Candidiasis der Leber nach erfolgreicher Chemotherapie einer akuten myeloischen Leukämie (FAB Typ 6) und Heilung durch perorale Fluconazol-Therapie.