Reverse use dependence of human ventricular repolarization by chronic oral sotalol in monophasic action potential recordings.
Reverse use dependence of action potential duration and effective refractory period by chronic oral sotalol was demonstrated by monophasic action potential recordings in the human ventricle. There were no changes of the QRS duration over the cycle length, indicating that sotalol had no sodium channel blocking effects.
Shimizu
W
W
Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan.
Kurita
T
T
Suyama
K
K
Aihara
N
N
Kamakura
S
S
Shimomura
K
K
D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000494:pharmacology* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000503:physiopathology; D016276:Ventricular Function / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D013015:Sotalol