Are single-dose toxicology studies in animals adequate to support single doses of a new drug in humans?
Monro
A
A
Pfizer Central Research, Groton, CT 06340, USA.
Mehta
D
D
D000818:Animals; D015510:Clinical Medicine; D064420:Drug-Related Side Effects and Adverse Reactions; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010600:Pharmacology; D013997:Time Factors; D014481:United States; D014486:United States Food and Drug Administration
D004364:Pharmaceutical Preparations