title: New variant Ph translocation in chronic myeloid leukemia: t(Y;22)(p11;q11).
abstract: A 4-year-old boy with chronic myeloid leukemia (CML) was shown to have a variant Ph t(Y;22)(p11;q11). To our knowledge, this is the first report of a variant Ph translocation involving Y. Molecular analysis showed that the breakpoint on chromosome 22 is in the breakpoint cluster region (bcr), typical of CML with the classic t(9;22), suggesting that it might be a complex Ph translocation with the involvement of 9q34.
authors.affiliation: Laboratorio de Citogenética, Servicio de Genética, Hospital de Pediatriá, "Juan P Garrahan," Buenos Aires, Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Gallego
authors.forename: E M
authors.initials: EM
authors.lastname: Baialardo
authors.forename: M
authors.initials: M
authors.lastname: Gutierrez
authors.forename: M
authors.initials: M
authors.lastname: Bonduel
authors.forename: A
authors.initials: A
authors.lastname: Feliu
mesh_terms: D002675:Child, Preschool; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic; D014998:Y Chromosome