title: Use of intravenous dofetilide in atrial flutter with hemodynamic instability.
abstract: Paroxysmal atrial flutter is a drug-resistant supraventricular tachyarrhythmia that is often accompanied by hemodynamic instability due to an excessive ventricular response. We report here a case of atrial flutter with 1:1 atrioventricular conduction, in which we were able to rescue the patient from a state of cardiogenic shock by using intravenous dofetilide, a new class III antiarrhythmic agent. Dofetilide was suitable for the treatment because it immediately increased atrioventricular nodal refractoriness without any negative inotropic action.
authors.affiliation: First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kuruma
authors.forename: H
authors.initials: H
authors.lastname: Atarashi
authors.forename: T
authors.initials: T
authors.lastname: Ino
authors.forename: M
authors.initials: M
authors.lastname: Yashima
authors.forename: A
authors.initials: A
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001282:Atrial Flutter / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D007275:Injections, Intravenous; D010627:Phenethylamines / Q000008:administration & dosage*; D013449:Sulfonamides / Q000008:administration & dosage*
chemical_list: D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D013449:Sulfonamides; C063533:dofetilide