Mechanism of suppression of cell-mediated immunity by measles virus.
The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.
Karp
C L
CL
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Wysocka
M
M
Wahl
L M
LM
Ahearn
J M
JM
Cuomo
P J
PJ
Sherry
B
B
Trinchieri
G
G
Griffin
D E
DE
D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000276:immunology / Q000502:physiology*; D001665:Binding Sites; D002478:Cells, Cultured; D018925:Chemokines / Q000096:biosynthesis; D003179:Complement C3b / Q000276:immunology / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis; D015536:Down-Regulation; D006801:Humans; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000502:physiology; D018664:Interleukin-12 / Q000096:biosynthesis*; D008459:Measles virus / Q000276:immunology* / Q000378:metabolism; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D009000:Monocytes / Q000276:immunology* / Q000821:virology*; D011991:Receptors, Virus / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; C497857:CD46 protein, human; D018925:Chemokines; D016207:Cytokines; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D016753:Interleukin-10; D018664:Interleukin-12; D003179:Complement C3b