[Effect of the histamine H2-receptor antagonist zantac on lipid peroxidation an antioxidant system in patients with gastroduodenal hemorrhage of ulcer etiology].
High lipid peroxidation rates and lower antioxidative protection were found in the serum of 64 patients with gastric (n = 20) and duodenal (n = 44) ulcers complicated by hemorrhage. The administration of zantac, a histamine H2-receptor blocker, considerably reduced lipid peroxidation and enhanced antioxidative activity, which positively affected the clinical course of diseases. The findings have led to the conclusion that zantac may have antioxidative properties.
Ermolov
A S
AS
Pakhomova
G V
GV
Taeritneva
L F
LF
Matveev
S B
SB
Marchenko
V V
VV
Golikov
P P
PP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D011899:Ranitidine / Q000494:pharmacology*
D000975:Antioxidants; D006635:Histamine H2 Antagonists; D011899:Ranitidine
Vliianie blokatora H2-retseptorov histamina--zantaka na perekisnoe okislenie lipidov i antioksidantnuiu sistemu u bol'nykh s gastroduodenal'nymi krovotecheniiami iazvennoĭ étiologii.