title: Response of Mycobacterium smegmatis to acid stress.
abstract: Evidence was sought for the existence of an inducible acid tolerance response in Mycobacterium smegmatis. Exposure of M. smegmatis to a sub-lethal, adaptive acidic pH was found to confer a significant level of protection against subsequent exposure to a lethal pH, compared to unadapted cells. Adaptation was dependent on de novo protein synthesis.
authors.affiliation: Department of Microbiology and Immunology, University of Leicester, UK.
authors.forename: L M
authors.initials: LM
authors.lastname: O'Brien
authors.forename: S V
authors.initials: SV
authors.lastname: Gordon
authors.forename: I S
authors.initials: IS
authors.lastname: Roberts
authors.forename: P W
authors.initials: PW
authors.lastname: Andrew
mesh_terms: D000143:Acids / Q000494:pharmacology*; D000222:Adaptation, Physiological / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D009161:Mycobacterium / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
chemical_list: D000143:Acids; D002701:Chloramphenicol