Nicotine self-administration in rats.
Considering the importance of self-administration models in determining mechanisms of drug maintained behavior, we attempted to replicate the findings of nicotine self-administration by Corrigall and Coen. Male, Sprague-Dawley rats, trained on food reinforcement, acquired relatively high and stable rates of self-administration of IV nicotine bitartrate (0.03 mg/kg, free base). Extinction and reacquisition followed substituting saline and then nicotine, respectively. Responses, infusions and intake decreased at 0.003 mg/kg, while intake increased at 0.06 mg/kg. This model of nicotine self-administration provides a reliable alternative to experimenter-administration models for examining the effects of nicotine.
Donny
E C
EC
Department of Psychology, University of Pittsburgh, PA 15260, USA.
Caggiula
A R
AR
Knopf
S
S
Brown
C
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
D018722:Nicotinic Agonists; D009538:Nicotine