title: Controlling IGF-receptor function: a possible strategy for tumor therapy.
abstract: The insulin-like growth factor-1 receptor (IGF-IR) is one of several growth-factor receptors that regulate the proliferation of mammalian cells. However, its ubiquitousness and certain unique aspects of its function make IGF-IR an ideal target for therapeutic interventions against abnormal growth, with very little effect on normal cells.
authors.affiliation: Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. baserga1@jeflin.rju.edu
authors.forename: R
authors.initials: R
authors.lastname: Baserga
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000639:trends*; D015316:Genetic Therapy / Q000639:trends*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000628:therapy*; D017526:Receptor, IGF Type 1 / Q000502:physiology*
chemical_list: D017526:Receptor, IGF Type 1