Predictive value of electron beam computed tomography of the coronary arteries. 19-month follow-up of 1173 asymptomatic subjects.
BACKGROUND
Coronary electron beam computed tomography (EBCT) detects atherosclerotic coronary artery disease by measuring calcium deposition in the walls of coronary arteries. EBCT-derived coronary artery calcium (CAC) scores correlate with the severity of underlying coronary artery disease.


RESULTS
We followed 1173 asymptomatic patients who underwent EBCT between September 1993 and March 1994. During average follow-up of 19 months, 18 subjects had 26 cardiovascular events: 1 death, 7 myocardial infarctions, 8 coronary artery bypass graft procedures, 9 coronary angioplasties, and 1 nonhemorrhagic stroke. For CAC score thresholds of 100, 160, and 680, EBCT had sensitivities of 89%, 89%, and 50% and specificities of 77%, 82%, and 95%, respectively. Odds ratios ranged from 20.0 to 35.4 (P < .0001 for all).


CONCLUSIONS
Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects.
Arad
Y
Y
Department of Preventive Cardiology, St Francis Hospital, Roslyn, NY 11576, USA.
Spadaro
L A
LA
Goodman
K
K
Lledo-Perez
A
A
Sherman
S
S
Lerner
G
G
Guerci
A D
AD
D017130:Angioplasty / Q000706:statistics & numerical data; D002545:Brain Ischemia / Q000453:epidemiology; D002114:Calcinosis / Q000000981:diagnostic imaging*; D002118:Calcium / Q000032:analysis; D017023:Coronary Angiography / Q000379:methods*; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000737:chemistry / Q000473:pathology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008403:Mass Screening; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D012372:ROC Curve; D012680:Sensitivity and Specificity
D002118:Calcium