title: Effect of terminal ileal transposition on intestinal absorption following proctocolectomy.
abstract: A terminal ileal transposition procedure, in which a distal jejunal segment is interposed between the terminal ileum and the anus following proctocolectomy, is described. Adult mongrel dogs had either terminal ileal transposition (n = 5) or ileoanal anastomosis (n = 6) following two-stage proctocolectomy. Untreated dogs were used as controls (n = 7). Twelve weeks after the second-stage operation, a perfusion study was performed. After terminal ileal transposition the transposed terminal ileum showed a high absorptive capability for sodium, chloride and bile acids (P < 0.05, P < 0.05 and P < 0.001 respectively). After ileoanal anastomosis the absorptive capability of the terminal ileum was not enhanced significantly. In the mid-jejunum, the absorption of bile acids, chloride and glucose was enhanced (all P < 0.05) only after terminal ileal transposition. Terminal ileal transposition improves the absorptive capability of the terminal ileum and the mid-jejunum compared with conventional ileoanal anastomosis in this model.
authors.affiliation: Department of Surgery 1, Kyushu University, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hotokezaka
authors.forename: S
authors.initials: S
authors.lastname: Nakahara
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Chijiiwa
authors.forename: R
authors.initials: R
authors.lastname: Mibu
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D007082:Ileum / Q000378:metabolism / Q000637:transplantation*; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism / Q000637:transplantation; D016737:Proctocolectomy, Restorative; D012964:Sodium / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D002712:Chlorides; D012964:Sodium; D005947:Glucose