A new XmnI polymorphism in the regulatory region of the corticotropin releasing hormone gene.
We describe the first polymorphism in the 5' flanking region of the corticotropin releasing hormone (CRH) gene. DNA sequencing analysis identified a T --> G base substitution in the 5' flanking region of the gene. This substitution leads to the loss of an XmnI site at position 255 of the Genbank entry X67661. The frequency analysis in 32 Caucasians revealed that it is a rare polymorphism, with only three observed heterozygous individuals for this polymorphism.
Baerwald
C G
CG
Molecular Immunogenetics and Rheumatology Units, United Medical and Dental School, London, UK.
Panayi
G S
GS
Lanchbury
J S
JS
D001483:Base Sequence; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis / Q000235:genetics*; D017931:DNA Primers; D015252:Deoxyribonucleases, Type II Site-Specific; D006580:Genetic Carrier Screening; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012045:Regulatory Sequences, Nucleic Acid
D017931:DNA Primers; D003346:Corticotropin-Releasing Hormone; C028649:endodeoxyribonuclease XmnI; D015252:Deoxyribonucleases, Type II Site-Specific