Atherosclerosis: an update.
CHD remains the leading cause of death in most developed countries; therefore, elucidation of risk factors and associated mechanisms for atherosclerosis and development of CHD has been a high priority. Data from the Framingham Heart Study and other large-scale epidemiologic studies have identified major risk factors associated with CHD, demonstrating the adverse effects of increased total and LDL-C levels and the protective effect of HDL-C. Other endogenous and exogenous risk factors have been identified and are discussed in this review. In addition, we address known mechanisms involved in the atherosclerotic process.
Basha
B J
BJ
Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Sowers
J R
JR
D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D003327:Coronary Disease / Q000209:etiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D008074:Lipoproteins / Q000378:metabolism; D008934:Mitogens / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D012307:Risk Factors
D006133:Growth Substances; D008074:Lipoproteins; D008934:Mitogens; D005346:Fibroblast Growth Factors