title: [Clinicopharmacological case report (3). Drug-induced angioedema].
abstract: We report the case of a patient with an angioedema during therapy with enalapril and tramadol. The most likely cause of the adverse effect if the ACE-inhibitor enalapril. A rechallenge with the ACE-inhibitor is dangerous and should not be performed. Because of its potential risks, further treatment with ACE-inhibitors should be avoided in all patients with ACE-inhibitor-induced angioedema. Possible therapeutic alternatives include diuretics, beta-blocking agents, calcium antagonists and also angiotensin II receptor antagonists.
authors.affiliation: Abteilung Klinische Pharmakologie und Toxikologie, Departement Innere Medizin, Universitätsspital Zürich.
authors.forename: B
authors.initials: B
authors.lastname: Kind
authors.forename: K
authors.initials: K
authors.lastname: Fattinger
authors.forename: S
authors.initials: S
authors.lastname: Krähenbühl
authors.forename: P J
authors.initials: PJ
authors.lastname: Meier-Abt
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects; D004656:Enalapril / Q000009:adverse effects*; D006801:Humans; D008297:Male; D014147:Tramadol / Q000009:adverse effects
chemical_list: D000701:Analgesics, Opioid; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D014147:Tramadol; D004656:Enalapril
vernacular_title: Der klinisch-pharmakologische Fall (3). Medikamentös bedingtes Angioödem.