title: HLA compatibility can be predicted by matching only three residues with outward oriented sidechains.
abstract: A new method of residue matching based on three polymorphic upward-oriented amino acid residues on the alpha-helices of the HLA molecule is described. The projected 10-year graft outcome for 1232 transplants with none of these residues mismatched was 47%, essentially the same as for 0 BDR-mismatched kidneys. The projected impact of allocation to recipients in a local pool based on the three residues was a 5% improvement in overall graft survival at 10 years.
authors.affiliation: UCLA Tissue Typing Laboratory 90024, USA.
authors.forename: S
authors.initials: S
authors.lastname: Takemoto
authors.forename: P I
authors.initials: PI
authors.lastname: Terasaki
mesh_terms: D000595:Amino Acid Sequence; D006085:Graft Survival / Q000276:immunology*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality; D011110:Polymorphism, Genetic; D012042:Registries; D015996:Survival Rate; D014015:Tissue Banks; D014481:United States
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens