The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin.
Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in this study of bone marrow transplantation between congenic mice. During the first 3-6 weeks after irradiation and marrow transfer, percentages of cells bearing the donor Thy-1 isotype in the periphery are much lower than percentages of T cells bearing the donor Gpi-1 marker. Apparently a population of Thy-1- donor T cells exists for several weeks after bone marrow transplantation. Further study showed that this population of CD3+, Thy-1- donor T cells expressed CD4+ or CD8+ and was found in peripheral blood and spleen but not in the thymus. This finding suggests their extrathymic origin.
Zhong
R K
RK
The University of Pittsburgh, Department of Medicine, PA 15213, USA.
Donnenberg
A D
AD
Edison
L
L
Harrison
D E
DE
D000818:Animals; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D013045:Species Specificity; D013154:Spleen / Q000201:enzymology / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000201:enzymology / Q000637:transplantation*; D018800:Thy-1 Antigens / Q000097:blood*
D015415:Biomarkers; D018800:Thy-1 Antigens; D005956:Glucose-6-Phosphate Isomerase