Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata.
Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.
François
G
G
Laboratorium voor Protozoölogie, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.
Passreiter
C M
CM
Woerdenbag
H J
HJ
Van Looveren
M
M
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents; D018288:Carcinoma, Small Cell; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms; D006801:Humans; D007783:Lactones; D008175:Lung Neoplasms; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000962:Antimalarials; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes