title: [Hemophilia B in a mixed breed male dog: treatment of a hemorrhagic crisis with fresh frozen plasma].
abstract: A 6 months old male crossbred dog became conspicuous because of a considerable haematoma in the region of the left thigh without recognizable exterior trauma. The results of the screening tests of the haemostatic system (distinctly prolonged activated partial thromboplastin time [aPTT], normal thromboplastin time and platelet count as well as a shortening of thrombin time) yielded a tentative diagnosis of haemophilia. Haemophilia B could be diagnosed on the basis of a distinctly and isolated reduced factor IX activity (8%, reference range: 70-140%). Two infusions with 20 ml/kg BW fresh frozen plasma each caused a clear clinical recovery of the patient. In addition, the efficacy of plasma infusion was documented in vitro by a temporary increase of factor IX activity as well as repeated measurements with the resonance thrombograph and of the aPTT.
authors.affiliation: Klinik für kleine Haustiere, Tierärztlichen Hochschule Hannover.
authors.forename: R
authors.initials: R
authors.lastname: Mischke
authors.forename: R
authors.initials: R
authors.lastname: Hänies
authors.forename: A
authors.initials: A
authors.lastname: Deniz
authors.forename: S
authors.initials: S
authors.lastname: Hart
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests / Q000662:veterinary; D016913:Blood Component Transfusion / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology / Q000628:therapy*; D004285:Dogs; D006406:Hematoma / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D002836:Hemophilia B / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010949:Plasma; D013848:Thigh
vernacular_title: Hämophilie B bei einem Mischlings-Rüden: Behandlung einer Blutungskrise mit frisch-gefrorenem Plasma.