title: [The relationship of PSA to age and prostatic volume in patients with benign prostatic hypertrophy].
abstract: Prostate specific antigen (PSA) is the most useful market for the diagnosis, staging and monitoring of prostate cancer. However, the effect of benign prostate hyperplasia on PSA levels is less well known. It has been reported that 20-45% of all adult males with BPH have PSA values over the normal range. To study this confounding factor we have analyzed the likely relationships between monoclonal PSA, age and prostate size as determined by ultrasound, in our series of 163 patients with BPH undergoing adenomectomy. Within the studied factors, the most conditioning parameter of PSA variability was prostate size. The correlation coefficient (r) was 0.61, with the determination coefficient (r2) being 0.037 (p < 0.001). Age correlation, although less important (r = 0.31), was statistically significant. Both variables were independent and resulted jointly in a correlation coefficient of 0.64. Also included is the mathematical formula used in our series to correlate PSA with age and prostate volume. Its application could mean an increased specificity of this tumoral marker.
authors.affiliation: Servicio de Urología, Hospital Universitario de Getafe, Madrid.
authors.forename: E
authors.initials: E
authors.lastname: Sánchez Sánchez
authors.forename: A
authors.initials: A
authors.lastname: Paez Borda
authors.forename: A
authors.initials: A
authors.lastname: Herrero Payo
authors.forename: J L
authors.initials: JL
authors.lastname: Ruiz Rubio
authors.forename: J
authors.initials: J
authors.lastname: Acebal Lucía
authors.forename: A
authors.initials: A
authors.lastname: Berenguer Sánchez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen
vernacular_title: Relación del PSA con la edad y el volumen prostático en pacientes con hiperplasia benigna de próstata.