Effects of the nonsteroidal anti-inflammatory drug piroxicam on energy metabolism in the perfused rat liver.
1. The actions of piroxicam, a nonsteroidal and noncarboxylic anti-inflammatory drug, on the metabolism of the isolated perfused rat liver were investigated. The main purpose was to verify if piroxicam is also active on glycogenolysis and energy metabolism, as demonstrated for several carboxylic nonsteroidal anti-inflammatories. 2. Piroxicam increased oxygen consumption in livers from both fed and fasted rats. 3. Piroxicam increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). 4. Gluconeogenesis from lactate plus pyruvate was inhibited. 5. The action of piroxicam on oxygen consumption was blocked by antimycin A, but not by atractyloside. 6. The action of piroxicam in the perfused rat liver metabolism seems to be a consequence of its action on mitochondria. 7. It can be concluded that inhibition of energy metabolism and stimulation of glycogenolysis are not specific properties of carboxylic nonsteroidal anti-inflammatory drugs.
Salgueiro-Pagadigorria
C L
CL
Department of Biochemistry, University of Maringá, Brazil.
Constantin
J
J
Bracht
A
A
Nascimento
E A
EA
Ishii-Iwamoto
E L
EL
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D000968:Antimycin A / Q000633:toxicity; D001278:Atractyloside / Q000633:toxicity; D004347:Drug Interactions; D004734:Energy Metabolism / Q000187:drug effects*; D005215:Fasting; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D010894:Piroxicam / Q000633:toxicity*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007773:Lactates; D011773:Pyruvates; D009243:NAD; D010894:Piroxicam; D001278:Atractyloside; D019344:Lactic Acid; D009249:NADP; D000968:Antimycin A; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate; D006003:Glycogen; D005947:Glucose