The novel antibacterial peptide ceratotoxin A alters permeability of the inner and outer membrane of Escherichia coli K-12.
Ceratotoxins are antibacterial 3-kDa amphiphilic peptides isolated from the female reproductive apparatus of the medfly Ceratitis capitata. The antibacterial activity of a chemically synthesized ceratotoxin A (ctx A) has been investigated. Ctx A was mainly active against Gram-negative organisms, and it had a lytic effect on nongrowing Escherichia coli K-12. Data showed that ctx A alters both the outer and the inner membrane of E.coli K-12 cells.
Marri
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Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Italy.
Dallai
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Marchini
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004175:Diptera; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007301:Insect Hormones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019476:Insect Proteins; D008970:Molecular Weight
D000900:Anti-Bacterial Agents; D007301:Insect Hormones; D019476:Insect Proteins; C082689:ceratotoxin A protein, Ceratitis capitata