[Preparation and antiviral properties of Bacillus intermedius ribonuclease modified by chloranhydride of adamantanecarboxylic acid].
Bacillus intermedius ribonuclease modified by the residue of adamantane carboxylic acid was prepared. When the cells of chick embryo fibroblasts infected by the fowl plague virus were exposed to the modified ribonuclease, the antiviral activity proved to be higher by comparison to that of the native enzyme. The chemotherapeutic index of the RNAse after the modification increased 4 times.
Kurinenko
B M
BM
Kalacheva
N V
NV
Muratov
P Iu
PIu
D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology*; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D015394:Molecular Structure; D012260:Ribonucleases / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000998:Antiviral Agents; C012698:adamantanecarboxylic acid; D012260:Ribonucleases; D000218:Adamantane
Poluchenie i protivovirusnye svoĭstva ribonukleazy "Bacillus intermedius", modifitsirovannoĭ khlorangidridom adamantankarbonovoĭ kisloty.