title: Superparamagnetic iron oxide (SPIO) as an oral contrast agent in gastrointestinal (GI) magnetic resonance imaging (MRI): comparison with state-of-the-art computed tomography (CT).
abstract: This study was conducted to compare the sensitivity and specificity of abdominal magnetic resonance imaging using oral superparamagnetic iron oxide with oral contrast-enhanced computed tomography in the detection of GI pathology. Overall sensitivity was calculated to be 83% for OECT compared to 67% by SPIO MRI. Specificity for OECT was 68% compared to 89% for SPIO MRI. The results from imaging with superparamagnetic iron oxide and imaging with oral contrast-enhanced computed tomography were in agreement in 14 subjects who had normal gastrointestinal tracts. In the remaining 16 patients, eight pathologic entities were detected by both modalities whereas 15 abnormalities were seen by only one modality. Superparamagnetic iron oxide magnetic resonance imaging was helpful in discriminating normal bowel from solid lesions and in detecting subtle gastrointestinal tract mass effect. In 30 consecutively studied patients suspected of having GI pathology, OECT was more sensitive than SPIO MRI in detecting abdominal pathology. Conversely, SPIO MRI was more specific than OECT.
authors.affiliation: Department of Radiology, University of Florida College of Medicine, Gainesville 32610-0374, USA.
authors.forename: W K
authors.initials: WK
authors.lastname: Johnson
authors.forename: C
authors.initials: C
authors.lastname: Stoupis
authors.forename: G M
authors.initials: GM
authors.lastname: Torres
authors.forename: E B
authors.initials: EB
authors.lastname: Rosenberg
authors.forename: P R
authors.initials: PR
authors.lastname: Ros
mesh_terms: D000284:Administration, Oral; D003287:Contrast Media / Q000008:administration & dosage*; D052203:Ferrosoferric Oxide; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging; D010087:Oxides; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide