title: Analysis of cross-over trials for duration data.
abstract: Survival models and cross-over designs both have an established place in biomedical research. Surprisingly, there are a few examples of proper exploitation of two in combination. A number of advantages and disadvantages of such studies are discussed. Two examples are used to illustrate the application of semi-Markov models with time-varying covariates, as standard log-linear models, to such data.
authors.affiliation: Department of Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium.
authors.forename: J K
authors.initials: JK
authors.lastname: Lindsey
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.forename: J A
authors.initials: JA
authors.lastname: Lewis
mesh_terms: D018592:Cross-Over Studies; D016014:Linear Models; D008390:Markov Chains; D015233:Models, Statistical; D016016:Proportional Hazards Models; D016019:Survival Analysis