title: Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma).
abstract: OBJECTIVE
  To examine the possible association between augmentation mammoplasty and systemic sclerosis (SSc; scleroderma).
  
  
  METHODS
  Eight hundred thirty-seven women with a clinical diagnosis of SSc, recruited as a volunteer sample from 3 university-based, tertiary care scleroderma clinical research centers, and 2,507 race-matched local control women, recruited by the technique of random-digit-dialing and frequency-matched on age, completed a questionnaire providing data on history of augmentation mammoplasty, including possible complications of the procedure. The odds ratio (OR) and 95 percent confidence interval (95% CI) for the association of augmentation mammoplasty with SSc were estimated by multivariate logistic regression analysis with adjustment for age, race and center, and by conditional logistic regression analysis with adjustment for age.
  
  
  RESULTS
  Eleven (1.31%) of the 837 cases reported a history of augmentation mammoplasty prior to diagnosis of SSc, compared with 31 (1.24%) of the 2,507 controls. The adjusted OR from the unmatched analysis was 1.07 (95% CI 0.53-2.13), while that from the matched analysis was 1.11 (95% CI 0.55-2.24).
  
  
  CONCLUSIONS
  These results fail to demonstrate a significant association between augmentation mammoplasty and SSc, and are consistent with those reported from other epidemiologic studies.
authors.affiliation: University of Maryland School of Medicine, Baltimore 21201, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Hochberg
authors.forename: D L
authors.initials: DL
authors.lastname: Perlmutter
authors.forename: T A
authors.initials: TA
authors.lastname: Medsger
authors.forename: K
authors.initials: K
authors.lastname: Nguyen
authors.forename: V
authors.initials: V
authors.lastname: Steen
authors.forename: M H
authors.initials: MH
authors.lastname: Weisman
authors.forename: B
authors.initials: B
authors.lastname: White
authors.forename: F M
authors.initials: FM
authors.lastname: Wigley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018427:Breast Implants; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000453:epidemiology / Q000209:etiology*; D012828:Silicones / Q000009:adverse effects*
chemical_list: D012828:Silicones