title: Multiple subpial transection for Landau-Kleffner syndrome.
abstract: Landau-Kleffner syndrome (LKS) is an acquired epileptic aphasia caused by a lesion in the speech centers of the cerebral cortex during a critical period of childhood development. Characteristics of LKS include language deterioration, seizure disorders, and severe electroencephalogram abnormalities. Multiple subpial transection (MST) is a surgical procedure that eliminates seizure activity in the cerebral cortex while preserving the child's normal cortical functions of speech, movement, primary sensation, and memory. This article presents a summary of clinical studies on LKS and discusses the diagnosis of LKS, traditional medical treatments, patient selection for MST procedures, and perioperative care of children undergoing MST procedures.
authors.affiliation: Rush Epilepsy Center, Rush-Presbyterian-St Luke's Medical Center, Chicago, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Buelow
authors.forename: P
authors.initials: P
authors.lastname: Aydelott
authors.forename: D M
authors.initials: DM
authors.lastname: Pierz
authors.forename: B
authors.initials: B
authors.lastname: Heck
mesh_terms: D002648:Child; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000188:drug therapy / Q000451:nursing* / Q000601:surgery*; D009730:Nursing Assessment; D013527:Perioperative Nursing; D016896:Treatment Outcome