title: New algorithmic-based digital filter processing system for real-time continuous blood pressure measurement and analysis in conscious rats.
abstract: A new algorithmic-based digital filter processing system for real-time continuous blood pressure (BP) measurement and analysis in freely-moving conscious rats has been developed. Real-time recognition of BP waveforms, real-time noise rejection and determination of representative waveform indexes (WIs) at indicated time points using digital filters and Smirnov's rejection test were realized with this system. Digital filters were applied for two different purposes: waveform segmentation and smoothing the calculations of representative WIs. Smirnov's rejection test was used for real-time noise rejection and yielded an accurate rejection rate of 99.99%. The result was that the digital filter processing and Smirnov's rejection test realized accurate real-time BP measurement and analysis in freely-moving conscious rats using a personal computer.
authors.affiliation: Department of Pharmacology, Dainippon Pharmaceutical Co., Ltd, Osaka, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Nagata
mesh_terms: D000465:Algorithms; D000818:Animals; D016477:Artifacts; D001794:Blood Pressure; D015924:Blood Pressure Monitors; D003198:Computer Simulation; D003199:Computer Systems; D003243:Consciousness; D008838:Microcomputers; D015233:Models, Statistical; D008991:Monitoring, Physiologic / Q000295:instrumentation; D010363:Pattern Recognition, Automated; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted