Telomeres of higher primates.
The telomeres of gorilla, chimpanzee and human peripheral blood cells have been examined by hybridization to an oligonucleotide probe, (TTAGGG)4, following conventional and pulsed-field electrophoresis procedures. The MspI site present near the chromosome terminus undergoes methylation in gorilla, chimpanzee and human genome as shown by the HpaII digestion. Minor (TTAGGG)4-hybridizing sequences have been also detected in the chimpanzee HindIII and MspI digests.
Bhatnagar
Y M
YM
Department of Structural & Cellular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA.
Mishra
P V
PV
Martinez
J A
JA
Saxena
K M
KM
Wertelecki
W
W
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D017124:Conserved Sequence; D015342:DNA Probes / Q000737:chemistry; D015247:Deoxyribonuclease HindIII; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry / Q000378:metabolism; D006071:Gorilla gorilla / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D008745:Methylation; D002679:Pan troglodytes / Q000235:genetics*; D015183:Restriction Mapping; D016615:Telomere / Q000737:chemistry / Q000235:genetics*
D015342:DNA Probes; D015247:Deoxyribonuclease HindIII; D015252:Deoxyribonucleases, Type II Site-Specific