[Study of pathogenetic mechanisms of intoxication in patients with anaerobic non-clostridial infection].
Pyoinflammatory diseases continue to be one of the most topical problem of modern medicine. Anaerobic non-clostridial infection is essential in the etiological pattern of pyoinflammatory diseases. Its specific feature is early developed severe intoxication. The authors have developed laboratory criteria for evaluating the degree of intoxication in patients with anaerobic non-clostridial infection, which are based on chromatographic determination of the concentrations of specific metabolic products, such as volatile fatty acids and toxic metabolites of the phenol group, in the patients' peripheral blood, which allows the detected disorders to be promptly corrected. The metabolic products of non spore-forming anaerobes, such as volatile fatty acids, are important pathogenetic factors since they inhibit the dynamic activity of platelets and the phagocytic activity of leukocytes in blood.
Istratov
V G
VG
Mironov
A Iu
AIu
Rudneva
V G
VG
Gorshenina
I Iu
IIu
Vorob'ev
A A
AA
D001421:Bacteria, Anaerobic / Q000302:isolation & purification / Q000378:metabolism; D001424:Bacterial Infections / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D001792:Blood Platelets / Q000502:physiology; D002845:Chromatography; D005232:Fatty Acids, Volatile / Q000097:blood; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D010587:Phagocytosis; D013492:Suppuration
D005232:Fatty Acids, Volatile
Izuchenie patogeneticheskikh mekhanizmov intoksikatsii u bol'nykh anaérobnoĭ neklostridial'noĭ infektsii.