Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates.
The nucleotide sequence encoding an approx. 120-kDa transcriptional repressor (MEB1) was determined from a cDNA which was cloned from a mouse brain library. An alignment of the deduced amino-acid sequences of the putative functional domains of MEB1 with those from the human, hamster and chicken homologues reveals a dramatic degree of conservation.
Genetta
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Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA. genetta@sunspark.med.upenn.edu
Kadesch
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002645:Chickens; D003001:Cloning, Molecular; D017124:Conserved Sequence; D006224:Cricetinae; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics; D018398:Homeodomain Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D012097:Repressor Proteins / Q000737:chemistry* / Q000235:genetics; D014157:Transcription Factors; D014158:Transcription, Genetic; D014714:Vertebrates; D000071799:Zinc Finger E-box-Binding Homeobox 1
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C486307:ZEB1 protein, human; D000071799:Zinc Finger E-box-Binding Homeobox 1