title: Development of subtle neurological signs after systemic illness in HIV-infected individuals.
abstract: Thirty human immunodeficiency virus (HIV) infected individuals entered a longitudinal study without signs of dysfunction of the central nervous system (CNS). Nine of these individuals developed a systemic illness between study visits, and 7 of these 9 patients (78%) had neurological signs at the next examination (e.g., action-intention tremors, abnormal gait, release signs, abnormal deep tendon reflexes). Only 2/21 (9.5%) of the subjects who did not develop systemic illness showed such signs. These data are consistent with the hypothesis that other factors (e.g. cytokines) as well as the HIV may cause subtle CNS dysfunction.
authors.affiliation: Department of Neurology, University of Pittsburgh School of Medicine, Pa, USA.
authors.forename: O L
authors.initials: OL
authors.lastname: Lopez
authors.forename: J T
authors.initials: JT
authors.lastname: Becker
authors.forename: G
authors.initials: G
authors.lastname: Banks
authors.forename: J
authors.initials: J
authors.lastname: Giconi
authors.forename: J
authors.initials: J
authors.lastname: Sanchez
authors.forename: S K
authors.initials: SK
authors.lastname: Dorst
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000503:physiopathology; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000503:physiopathology; D000328:Adult; D001921:Brain / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests
chemical_list: D016207:Cytokines