-Cytokine level in malignant ascites and peripheral blood of patients with advanced ovarian carcinoma-.
The concentrations of various cytokines were examined by ELISA in blood and in ascites from 14 patients with advanced ovarian cancer (stage IV). The control group consisted of 6 patients with benign gynaecological disorders. Compared with patients with benign gynaecological disorders, ascites and/or plasma of patients with ovarian cancer showed significantly higher levels of IL-6, IL-8, IL-10, TNF-alpha, and sIL-2R. There were no increases of IL-1 alpha, IL-1 beta, IL-2, IFN-gamma, and sCD14 levels. The possible pathogenetic significance of cytokines in ovarian cancer is discussed.
Radke
J
J
Universitätsfrauenklinik, Medizinischen Fakultät, Otto-von-Guericke-Universität Magdeburg.
Schmidt
D
D
Böhme
M
M
Schmidt
U
U
Weise
W
W
Morenz
J
J
D000328:Adult; D001202:Ascitic Fluid / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012016:Reference Values
D016207:Cytokines
Zytokinspiegel im malignen Aszites und peripheren Blut von Patientinnen mit fortgeschrittenem Ovarialkarzinom.