[The intravascular formation of kinins in the brain studied as a new approach to the problem of the re-circulatory complications in the surgical treatment of cerebral ischemia].
The improvement of blood supply in the ischemic brain (post-ischemic cerebral reperfusion), which results from surgical treatment, has been shown to improve the neurological status only in the patients who had no lower baseline levels of kininogens (the production of free kinins) in cerebral circulation. Poor surgical outcomes were noted in the cases wherein there was preoperative activated kinin production when blood passed through the brain. Postischemic brain reperfusion was concurrent with kinin production in the cerebral vascular bed in all examinees, but in patients with postoperative complications this process is more active and involves the two kinin-forming systems tissue and plasma ones. It is hypothesized that in the latter case kinins convert from the compensatory to the pathogenetic factor of secondary circulatory disorders. The correlations found may be used to substantiate the use of antikinin therapy and to develop a biochemical test that predicts possible complications after surgical treatment of cerebral circulatory ischemia.
Makevnina
L G
LG
Zubkov
Iu N
IuN
Lomova
I P
IP
Semeniutin
V B
VB
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002545:Brain Ischemia / Q000378:metabolism* / Q000601:surgery; D002536:Cerebral Arteries / Q000378:metabolism*; D002550:Cerebral Veins / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007705:Kinins / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011183:Postoperative Complications / Q000097:blood*; D011184:Postoperative Period
D007705:Kinins
Izuchenie vnutrisosudistogo obrazovaniia kininov v golovnom mozge kak novyĭ podkhod k probleme retsirkuliatornykh oslozhneniĭ pri khirurgicheskom lechenii tserebral'noĭ ischemii.