[The effect of acute hypoxia on the cytogenetic effect of cyclophosphamide in rat bone marrow cells, differing in resistance to oxygen deficiency].
The frequency of chromosomal aberrations in rat bone marrow cells injected with intraperitoneal cyclophosphamide (CF) during the 24 h after acute hypoxia was studied. We used two groups of rats: a group with low resistance (LR) to acute hypoxia that was unable to endure more than 5 min in a vacuum chamber at the altitude of 11,000 m, and a group of highly resistant (HR) rats able to endure 25 min or longer under the above conditions in vacuum chamber. Acute hypoxia was shown to enhance the cytogenetic activity of cyclophosphamide, and the number of chromosomal aberrations was higher in HR rats than in LR animals.
Bykovskaia
N V
NV
Khaĭtsev
N V
NV
Shvartsman
P Ia
PIa
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000503:physiopathology; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity*; D004198:Disease Susceptibility; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D010100:Oxygen; D051381:Rats
D009153:Mutagens; D003520:Cyclophosphamide; D010100:Oxygen
Vliianie ostroĭ gipoksii na tsitogeneticheskiĭ éffekt tsiklofosfana v kletkakh kostnogo mozga krys, razlichaiushchikhsia po ustoĭchivosti k kislorodnoĭ nedostatochnosti.