Effects of a vigilance-enhancing drug, modafinil, on rat brain metabolism: a 2D COSY 1H-NMR study.
The effects of modafinil, a vigilance-enhancing drug, on brain metabolism were investigated directly in situ by the 2D COSY 1H-NMR spectroscopy in anesthetized rats. Modafinil (600 mg/kg, i.p.) induced significant increases in both aspartate (72% +/- 15%) and glutamate-glutamine pool (28% +/- 8%) simultaneously with increases in inositol (51% +/- 19%) and creatine-phosphocreatine pool (47% +/- 14%) in comparison with control values (P < 0.05; n = 5). These results suggest that the awakening properties of modafinil could be mediated by metabolic activation.
Piérard
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C
Dept. de Physiologie Systémique, Institut de Médecine Aérospatiale (IMASSA-CERMA), Bretigny Sur Orge, France.
Satabin
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P
Lagarde
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D
Barrère
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B
Guezennec
C Y
CY
Menu
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JP
Pérès
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M
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D003401:Creatine / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D000077408:Modafinil; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D010725:Phosphocreatine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; D003401:Creatine; D000077408:Modafinil