title: Granulocytic sarcoma in nonleukemic children: report of two new cases successfully treated by local radiation therapy and systemic chemotherapy.
abstract: Granulocytic sarcoma (GS) is a rare tumor composed of immature myeloid cells. Exceedingly rare in childhood, it has more commonly been described in association with acute myeloid leukemia. Occasional nonleukemic patients generally go on to develop overt leukemia in a mean period of 10.5 months from diagnosis of GS. We report here two new cases of GS diagnosed in nonleukemic children. They were successfully treated with local radiation therapy and conventional systemic chemotherapy. The need to suspect more often this all too frequently misdiagnosed disease is emphasized. The role of optimally delivered radiation therapy in achieving and maintaining local control of the tumor is discussed.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University Federico II, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fiorillo
authors.forename: G
authors.initials: G
authors.lastname: de Rosa
authors.forename: G
authors.initials: G
authors.lastname: Canale
authors.forename: I
authors.initials: I
authors.lastname: Fariello
authors.forename: R
authors.initials: R
authors.lastname: D'Amore
authors.forename: G
authors.initials: G
authors.lastname: Bonavolontà
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*