[Low-dose desmopressin (DDAVP) and blood levels of FSH, LH and testosterone in men].
The effect of desmopressin (DDAVP) administration (2.5 micrograms/12 hours) on serum concentrations of FSH, LH and testosterone was studied in six men. No significant changes were observed in serum concentrations of FSH and LH after 9 days with DDAVP therapy. Nevertheless, serum concentrations of testosterone after 12 hours of DDAVP administration were significantly higher than basal concentrations. Three hours after the administration of DDAVP, serum testosterone concentrations decreased significantly. The conclusion reached was that low doses of desmopressin do not change serum concentrations of FSH and LH, but serum concentration of testosterone is decreased within three hours after the administration, although an increase is observed 12 hours later possibly due to a "rebound effect". Desmopressin would therefore directly act upon human testicle.
García-Pascual
I J
IJ
Sección de Planificación Familiar y Fertilidad, Centro Médico San José de Tiabaya, Arequipa, Peru.
Rozán Flores
M A
MA
D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D012076:Renal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D012076:Renal Agents; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003894:Deamino Arginine Vasopressin
Desmopresina (DDAVP) a pequeñas dosis y concentraciones séricas de FSH, LH y testosterona en el hombre.