title: Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III.
abstract: We have isolated and characterized the immediate (1651 bP) 5'-flanking region of the gene (GnT-III) encoding N-acetylglucosaminyltransferase III (GnT-III) from a human placental genomic library. Analysis of promoter elements shows a similarity to the 5'-flanking region of murine 1,4-galactosyltransferase. The sequence lacks obvious TATA elements and CCAAT boxes; however, putative regulatory sites, including 2 potential cAMP-response regulatory elements (CRE), 11 insulin-response element consensus sequences (IRE), 7 potential AP-2 binding sites, 2 SP1 consensus sequences (GC boxes) and 2 sequences similar to the half-palindromic glucocorticoid-responsive element (GRE), are present.
authors.affiliation: Laboratory of Molecular and Cellular Biology, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Taejon, South Korea.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: K S
authors.initials: KS
authors.lastname: Kim
authors.forename: J E
authors.initials: JE
authors.lastname: Chang
authors.forename: J H
authors.initials: JH
authors.lastname: Ko
authors.forename: M H
authors.initials: MH
authors.lastname: Kim
authors.forename: D H
authors.initials: DH
authors.lastname: Chung
authors.forename: T W
authors.initials: TW
authors.lastname: Chung
authors.forename: I S
authors.initials: IS
authors.lastname: Choe
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D004247:DNA; D017351:N-Acetylglucosaminyltransferases; C054599:beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase