title: Soluble E-selectin levels in acute human myocardial infarction.
abstract: It has been suggested that leukocyte adhesion mechanisms play a key role in experimental myocardial infarction. We have recently shown that E-selectin, an adhesion molecule belonging to the selectin family, is involved in the pathogenesis of experimental myocardial ischemia. We investigated the circulating levels of E-selectin, studied as a marker of endothelial dysfunction, in acute myocardial infarction. Our study was carried out in 60 patients, 20 hospitalized for acute myocardial infarction, 20 suffered from angina pectoris and 20 healthy control subjects. Patients with acute myocardial infarction had increased serum levels of soluble E-selectin (sE-selectin = 255 +/- 12 ng/ml) compared to both patients with angina pectoris (sE-selectin = 51 +/- 14 ng/ml). Thrombolytic therapy with urokinase (1,000,000 IU as an intravenous bolus in 5 min, followed by producing reperfusion and reduced the serum levels of sE-selectin (71 +/- 19 ng/ml). Our results confirm previous experimental data and indicate that adhesion mechanisms supporting leukocyte-endothelium interaction may also be operative in human acute myocardial infarction.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Squadrito
authors.forename: D
authors.initials: D
authors.lastname: Altavilla
authors.forename: M
authors.initials: M
authors.lastname: Ioculano
authors.forename: P
authors.initials: P
authors.lastname: Canale
authors.forename: G M
authors.initials: GM
authors.lastname: Campo
authors.forename: G
authors.initials: G
authors.lastname: Squadrito
authors.forename: G
authors.initials: G
authors.lastname: Ditano
authors.forename: F
authors.initials: F
authors.lastname: Freni
authors.forename: A
authors.initials: A
authors.lastname: Saitta
authors.forename: A P
authors.initials: AP
authors.lastname: Caputi
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000502:physiology; D019040:E-Selectin / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D015425:Myocardial Reperfusion; D012995:Solubility; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D014568:Urokinase-Type Plasminogen Activator