Persistence of cyclosporine after withdrawal of the drug in a patient with chronic liver transplant rejection. Role of the monoethylglycinexylidine test.
Patients with chronic rejection of liver allografts may show persistently high cyclosporine levels. This phenomenon may be due to a down-regulation of the P450 cytochrome system. The monoethylglycinexylidine test was useful in confirming this hypothesis.
Jindal
R M
RM
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA.
Pescovitz
M D
MD
Cummings
O W
OW
Book
B
B
Lumeng
L
L
Milgrom
M L
ML
Leapman
S B
SB
Filo
R S
RS
D000328:Adult; D016572:Cyclosporine / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics*; D016031:Liver Transplantation
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System