All-trans-retinoic acid and pseudotumor cerebri in a young adult with acute promyelocytic leukemia: a possible disease association.
Pseudotumor cerebri or idiopathic intracranial hypertension is a neurological syndrome characterized by signs and symptoms of intracranial hypertension without clinical or radiological evidence of infective or space occupying lesions. Iatrogenic factors are frequent; in particular, cases of pseudotumor cerebri associated with all-trans-retinoic acid treatment in acute promyelocytic leukemia (APL) have been frequently described in pediatric patients. We report on a case observed in an older patient (young adult age) and give diagnostic and therapeutic guidelines.
Visani
G
G
Institute of Hematology L. & A. Seragnoli, University of Bologna, Italy.
Bontempo
G
G
Manfroi
S
S
Pazzaglia
A
A
D'Alessandro
R
R
Tura
S
S
D000293:Adolescent; D006801:Humans; D007049:Iatrogenic Disease; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D014212:Tretinoin / Q000009:adverse effects*
D014212:Tretinoin