A model for cross-over trials evaluating therapeutic preferences.
A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This can be modelled using a geometric distribution. The model can be simply fitted using standard logistic regression methodology. The procedure is applied to a trial studying the effects of bronchodilators in the treatment of chronic asthma.
Lindsey
J K
JK
Department of Medical Statistics, School of Computing Sciences, De Monfort University, Leicester, UK.
Jones
B
B
D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002908:Chronic Disease; D018592:Cross-Over Studies; D005069:Evaluation Studies as Topic; D006801:Humans; D016015:Logistic Models; D012044:Regression Analysis
D001993:Bronchodilator Agents