title: Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature.
abstract: BACKGROUND
  Simple excision of earlobe keloids can result in recurrence rates approaching 80%. Many modalities have been suggested to reduce the risk of recurrence postoperatively, including intralesional steroids and radiotherapy.
  
  
  OBJECTIVE
  In order to determine the most reliable method to prevent keloid recurrence, we have conducted the first randomized, prospective trial comparing corticosteroid injections versus radiation therapy.
  
  
  RESULTS
  Thirty-one keloids were treated and followed for a minimum of 12.0 months. Two of 16 keloids (12.5%) recurred after surgery and radiation therapy, while 4 of 12 (33%) recurred after surgery and steroid injections. No alteration of skin pigmentation, wound dehiscence, chronic dermatitis, or neoplastic changes was observed in any patient in either group. Although a statistically significant difference was not observed, radiotherapy appeared to be more effective than steroid injections in preventing keloid recurrence.
  
  
  CONCLUSIONS
  Radiotherapy is a simpler treatment modality with better patient compliance, and patients were much more likely to complete treatment than with corticosteroid injections. We believe that radiotherapy can play an important role in the prevention of earlobe keloid recurrences, and that with current techniques, complications can be minimized. Further randomized study with additional patients is needed to compare the effectiveness of corticosteroid injections and radiotherapy in preventing keloid recurrence.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Beth Israel Medical Center, New York, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Sclafani
authors.forename: L
authors.initials: L
authors.lastname: Gordon
authors.forename: M
authors.initials: M
authors.lastname: Chadha
authors.forename: T
authors.initials: T
authors.lastname: Romo
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004427:Ear Diseases / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D004431:Ear, External / Q000601:surgery; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D011182:Postoperative Care; D011183:Postoperative Complications / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012008:Recurrence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide