[Biological properties and clinical importance of interleukin 1].
The paper presents the molecular biology and biological activity of IL-1 alpha, IL-1 beta and IL-1 receptor antagonist. The role of IL-1 family in pathogenesis of a various disease including myeloid leukemias and other neoplastic diseases, diabetes mellitus, inflammatory diseases, sepsis syndrome and atherosclerosis is presented. Potential therapeutic value of IL-1 and IL-1 receptor antagonist is also discussed.
Robak
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II Klinika Chorób Wewnetrznych Akademii Medycznej w Lodzi.
D000595:Amino Acid Sequence; D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D001424:Bacterial Infections / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D007375:Interleukin-1 / Q000502:physiology*; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000503:physiopathology; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors / Q000235:genetics
D007375:Interleukin-1; D017472:Receptors, Interleukin-1
Właściwości biologiczne i znaczenie kliniczne interleukiny 1.