title: The noncoding and surface envelope coding sequences of myeloblastosis-associated virus are respectively responsible for nephroblastoma development and renal hyperplasia.
abstract: The use of chimeric viruses allowed us to establish that myeloblastosis-associated virus long terminal repeat sequences are necessary and sufficient for induction of nephroblastoma in chickens and that the blastemal hyperplasia induced by env SU is not a prerequisite for tumor development but rather constitutes a predisposing stage.
authors.affiliation: Laboratoire d'Oncologie Virale et Moléculaire, Centre National de la Recherche Scientifique-UMR 146, Institut Curie, Centre Universitaire, Orsay, France.
authors.forename: V
authors.initials: V
authors.lastname: Joliot
authors.forename: C
authors.initials: C
authors.lastname: Khelifi
authors.forename: M
authors.initials: M
authors.lastname: Wyers
authors.forename: G
authors.initials: G
authors.lastname: Dambrine
authors.forename: F
authors.initials: F
authors.lastname: Lasserre
authors.forename: P
authors.initials: P
authors.lastname: Lemercier
authors.forename: B
authors.initials: B
authors.lastname: Perbal
mesh_terms: D000818:Animals; D001353:Avian Leukosis / Q000821:virology*; D009189:Avian Myeloblastosis Virus / Q000235:genetics* / Q000472:pathogenicity; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000472:pathogenicity; D002645:Chickens / Q000821:virology; D015752:Genes, env / Q000502:physiology*; D006965:Hyperplasia / Q000821:virology; D007438:Introns; D007668:Kidney / Q000473:pathology* / Q000821:virology; D007680:Kidney Neoplasms / Q000662:veterinary* / Q000821:virology; D011201:Poultry Diseases / Q000821:virology*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics* / Q000502:physiology; D012192:Retroviridae Infections / Q000662:veterinary* / Q000821:virology; D009396:Wilms Tumor / Q000662:veterinary* / Q000821:virology