title: Intraoperative ventilation with air and oxygen during laparoscopic cholecystectomy decreases the degree of postoperative hypoxaemia.
abstract: We studied the effects of intraoperative use of air in oxygen (O2) (FiO2 = 0.33) versus nitrous oxide (N2O) in O2 (FiO2 = 0.33) on the degree of postoperative hypoxaemia in 30 patients undergoing laparoscopic cholecystectomy. Patients were randomly allocated to receive either general anaesthesia with air (Group A, n = 15) or with N2O (Group N, n = 15). Arterial gas tensions were measured before, 24 h and 48 h after surgery while breathing room air. The mean PaO2 24 h and 48 h postoperatively decreased significantly in both groups compared with the preoperative values. The mean PaO2 24 h postoperatively in Group N (74.6 +/- 6.4 mmHg) tended to be lower than that in Group A (78.1 +/- 8.3 mmHg). The mean PaO2 48 h postoperatively in Group N (75.0 +/- 7.8 mmHg) was significantly lower than that in Group A (83.5 +/- 7.9 mmHg) (P < 0.05). On the contrary, the mean PaCO2 did not show any significant change during 48 h postoperatively in either group. Our results suggest that ventilation with N2O and O2 during laparoscopic cholecystectomy is associated with a lower degree of postoperative hypoxaemia.
authors.affiliation: Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Toyooka
mesh_terms: D000328:Adult; D001784:Blood Gas Analysis; D002763:Cholecystectomy; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage; D010100:Oxygen / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control*; D012121:Respiration, Artificial
chemical_list: D009609:Nitrous Oxide; D010100:Oxygen