The effect of thymectomy on myasthenia gravis, thrombocytopenia, and granulocytopenia associated with thymoma: report of a case.
We report the case of a 47-year-old woman with thymoma who developed myasthenia gravis, thrombocytopenia, and granulocytopenia, simultaneously, the concurrent association of these four disorders being extremely rare. Thymectomy was performed, and, during the post-thymectomy course, there were surprising findings concerning the recovery of not only the myasthenia gravis but also of the hematologic disorders. Immediately after thymectomy, the myasthenic symptoms completely disappeared, and the granulocyte and platelet counts recovered to within the normal range within a few days. The laboratory data revealed no difference between pre- and post-thymectomy in the release of cytokines (tumor necrosis factor; TNF, interleukin; IL-2, and IL-6), anti-acetylcholine receptor antibody, or platelet-associated IgG. On the other hand, the serum level of anti-neutrophil cytoplasmic antibody (p-ANCA), against the myeloperoxidase of the granulocytes was dramatically decreased, after thymectomy, showing a significant correlation with the granulocyte count. According to our survey of the literature, this is the first report to show that the removal of a thymoma led to the dramatic resolution not only of myasthenia gravis but also of other associated diseases. It is possible that p-ANCA may be regulated by thymoma, thus causing severe granulocytopenia.
Kobayashi
M
M
First Department of Surgery, Hirosaki University School of Medicine, Aomori, Japan.
Hasegawa
T
T
Iwabuchi
S
S
Fukushima
M
M
Koie
H
H
Kannari
K
K
D000380:Agranulocytosis / Q000276:immunology / Q000601:surgery*; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology / Q000601:surgery*; D010976:Platelet Count; D011183:Postoperative Complications / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology / Q000601:surgery*; D013934:Thymectomy; D013945:Thymoma / Q000276:immunology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000276:immunology / Q000601:surgery*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D016207:Cytokines