title: Fetal cerebral Doppler studies as a predictor of perinatal outcome and subsequent neurologic handicap.
abstract: OBJECTIVE
  To study the use of middle cerebral arterial Doppler findings in a group of high-risk fetuses as a predictor of adverse perinatal outcome, including subsequent neurologic handicap.
  
  
  METHODS
  A group of very high-risk fetuses was recruited over a 2-year period for study. Weekly fetal biometries and Doppler studies of the umbilical artery and middle cerebral arteries were carried out until delivery. Main outcome indices analyzed included birth weight ratio (ratio of observed birth weight to mean birth weight for gestation), days of ventilator requirement, neonatal intracranial hemorrhage or periventricular leukomalacia, necrotizing enterocolitis, and follow-up data on major neurologic handicap and death.
  
  
  RESULTS
  Seventy-four patients were recruited. One hundred thirty-four sets of examinations were made and prospective follow-up data were available for up to 2 years. The ratio of the umbilical and middle cerebral arterial resistance index was found to be inversely proportional to the birth weight ratio. Fetuses who had a high prenatal umbilical-cerebral Doppler ratio had significantly lower birth weight ratios than those with normal findings (0.72 versus 0.92; P < .001). The ratio was a more sensitive marker for growth restriction (sensitivity 78%) than conventional fetal biometry and umbilical arterial systolic-diastolic ratio. However, fetuses with high ratios did not have higher incidences of perinatal complications or subsequent neurologic handicap.
  
  
  CONCLUSIONS
  Prenatal cerebral vasodilation is a sensitive marker for growth restriction and it seems to be a physiologic response to hypoxia. Fetuses with intrauterine cerebral vasodilation do not have increased risk for subsequent gross neurologic damage.
authors.affiliation: Department of Obstetrics & Gynaecology, Mater Misericordiae Mothers' Hospital, South Brisbane, Australia.
authors.forename: F Y
authors.initials: FY
authors.lastname: Chan
authors.forename: T C
authors.initials: TC
authors.lastname: Pun
authors.forename: P
authors.initials: P
authors.lastname: Lam
authors.forename: C
authors.initials: C
authors.lastname: Lam
authors.forename: C P
authors.initials: CP
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Lam
mesh_terms: D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000503:physiopathology; D014655:Vascular Resistance; D014664:Vasodilation