title: CD-44 is not involved in the metastatic spread of ovarian cancer in vivo.
abstract: It has been shown that isoforms of the adhesion molecule CD44 are involved in the metastatic spread of several human malignancies. To determine whether CD44 plays a role in metastasis of human ovarian cancer, the tumours and corresponding metastases of 28 patients were investigated. CD44 was detected by immunohistochemistry in 2 primary tumours (7.1%) and 3 metastases (10.7%). In no case did both the primary tumour and metastasis show CD44 expression simultaneously. The results presented here suggest that CD44 does not play a crucial role in the metastatic spread of human ovarian cancer.
authors.affiliation: University Hospital Vienna, Medical School, Department of Obstetrics and Gynecology, Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Speiser
authors.forename: C
authors.initials: C
authors.lastname: Wanner
authors.forename: G
authors.initials: G
authors.lastname: Breitenecker
authors.forename: P
authors.initials: P
authors.lastname: Kohlberger
authors.forename: C
authors.initials: C
authors.lastname: Kainz
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology*; D012326:RNA Splicing
chemical_list: D000951:Antigens, Neoplasm; D018960:Hyaluronan Receptors