title: The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA.
abstract: The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements.
authors.affiliation: Department of Clinical Chemistry, Lund University, University Hospital, Malmö, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Lundwall
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA; D012739:Gonadal Steroid Hormones / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D012091:Repetitive Sequences, Nucleic Acid; D029607:Seminal Vesicle Secretory Proteins; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012739:Gonadal Steroid Hormones; D029607:Seminal Vesicle Secretory Proteins; C424482:seminal vesicle-specific antigen; D004247:DNA