title: [Evaluation of reactivity and immunogenicity of a cultured concentrated inactivated vaccine against hepatitis A "Hep-A-In-Vak"].
abstract: Clinical trials of inactivated hepatitis A vaccine Hep-A-in-Vac demonstrated its specific safety and moderate reactogenicity, manifesting by short-term fibrillar twitching of musculus deltoideus at the site of injection. After a course of three immunizations 87.5% seronegative vaccines developed a high level of specific antibodies to hepatitis A virus with at least 100 reverse values of titers. In controls antibody titers remained seronegative in 90% cases. These data indicate evident immunologic activity of Hep-A-in-Vac vaccine.
authors.forename: M A
authors.initials: MA
authors.lastname: Gorbunov
authors.forename: L I
authors.initials: LI
authors.lastname: Pavlova
authors.forename: L G
authors.initials: LG
authors.lastname: Karpovich
authors.forename: T V
authors.initials: TV
authors.lastname: Kalashnikova
authors.forename: T A
authors.initials: TA
authors.lastname: Bektimirov
authors.forename: V D
authors.initials: VD
authors.lastname: Levina
authors.forename: A G
authors.initials: AG
authors.lastname: Maĭdaniuk
authors.forename: T N
authors.initials: TN
authors.lastname: Ermolaeva
authors.forename: V I
authors.initials: VI
authors.lastname: Shervarli
authors.forename: B P
authors.initials: BP
authors.lastname: Balashev
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D006506:Hepatitis A / Q000276:immunology* / Q000517:prevention & control; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D014765:Viral Vaccines / Q000096:biosynthesis / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines
vernacular_title: Otsenka reaktogennosti i immunogennosti kul'tural'noĭ kontsentrirovannoĭ inaktivirovannoĭ vaktsiny protiv gepatita A "Gep-A-In-Vak".