title: [Decreased bone mineral density in patients with insulin-dependent-diabetes].
abstract: The aim of study was an evaluation of bone mineral density (BMD) measured by LUNAR DPX-L System in lumbar spine (AP), total body and distal site of forearm (Forearm) in patients with insulin-dependent diabetes mellitus (IDDM), in relation to duration of the disease, degree of metabolic control and serum osteocalcin (OC). The study was performed on 58 patients with IDDM (26 F, 32 M; mean age: 40.1 +/- 10 yrs, mean duration of IDDM: 17.2 +/- 8 yrs) and 33 healthy, age-matched subjects (18 F, 15 M). Patients with overt nephropathy, concomitant diseases known to affect bone metabolism and women after menopause were excluded from the study. BMD was decreased in patients with IDDM in comparison with the controls: 1.13 +/- 0.1 vs 1.25 +/- 0.15 g/cm2, p < 0.001 in AP, 1.12 +/- 0.07 vs 1.2 +/- 0.07 g/cm2, p < 0.001 in Total body oraz 0.37 +/- 0.05 vs 0.4 +/- 0.05 g/cm2, p < 0.05 in Forearm. The degree of metabolic control of IDDM evaluated by serum HbAlc levels did not influence the values of BMD. Similarly, duration of IDDM did not correlate with BMD. OC level was significantly higher in diabetic patients than in control group: 4.88 +/- 2.2 vs 3.89 +/- 1.2 ng/ml, p < 0.05.
  
  
  CONCLUSIONS
  1) In patients with long-standing IDDM, Total Body, AP Spine and Forearm BMD were significantly decreased in comparison with the controls, and the decrease of BMD was higher in men than in women. 2) In patients with IDDM the decrease of BMD did not depend on the degree of metabolic control and duration of the disease. 3) Serum OC determinations may help in the identification of cases with risk of development of diabetic osteopenia.
authors.affiliation: Kliniki Endokrynologii, Nadciśnienia Tetniczego i Chorób Przemiany Materii Pomorskiej Akademii Medycznej w Szczecinie.
authors.forename: T
authors.initials: T
authors.lastname: Miazgowski
authors.forename: E
authors.initials: E
authors.lastname: Andrysiak-Mamos
authors.forename: S
authors.initials: S
authors.lastname: Czekalski
authors.forename: S
authors.initials: S
authors.lastname: Pynka
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005542:Forearm; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011863:Radioimmunoassay; D017678:Sex Distribution
chemical_list: D015675:Osteocalcin
vernacular_title: Obnizona gestość mineralna kości u chorych zcukrzyca insulinozalezna