The noncoding and surface envelope coding sequences of myeloblastosis-associated virus are respectively responsible for nephroblastoma development and renal hyperplasia.
The use of chimeric viruses allowed us to establish that myeloblastosis-associated virus long terminal repeat sequences are necessary and sufficient for induction of nephroblastoma in chickens and that the blastemal hyperplasia induced by env SU is not a prerequisite for tumor development but rather constitutes a predisposing stage.
Joliot
V
V
Laboratoire d'Oncologie Virale et Moléculaire, Centre National de la Recherche Scientifique-UMR 146, Institut Curie, Centre Universitaire, Orsay, France.
Khelifi
C
C
Wyers
M
M
Dambrine
G
G
Lasserre
F
F
Lemercier
P
P
Perbal
B
B
D000818:Animals; D001353:Avian Leukosis / Q000821:virology*; D009189:Avian Myeloblastosis Virus / Q000235:genetics* / Q000472:pathogenicity; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000472:pathogenicity; D002645:Chickens / Q000821:virology; D015752:Genes, env / Q000502:physiology*; D006965:Hyperplasia / Q000821:virology; D007438:Introns; D007668:Kidney / Q000473:pathology* / Q000821:virology; D007680:Kidney Neoplasms / Q000662:veterinary* / Q000821:virology; D011201:Poultry Diseases / Q000821:virology*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics* / Q000502:physiology; D012192:Retroviridae Infections / Q000662:veterinary* / Q000821:virology; D009396:Wilms Tumor / Q000662:veterinary* / Q000821:virology