A new analogue of nifurtimox.
1-¿[(5-Nitro-2-furyl)methylene]amino¿-1,2,4-triazole, C7H5N5O3, is a new analogue of nifurtimox with activity against Tripanosoma cruzi. In the crystal structure, the molecule lies on a mirror plane and has an E-sZ conformation along the N = C-C moiety. The molecules are linked through C-H...O and C-H...N interactions.
Caracelli
I
I
Instituto de Física e Química de São Carlos, Universidade de São Paulo, Brazil.
Stamato
F M
FM
Mester
B
B
Paulino
M
M
Cerecetto
H
H
D000981:Antiprotozoal Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009547:Nifurtimox / Q000031:analogs & derivatives*; D014230:Triazoles / Q000737:chemistry*
D000981:Antiprotozoal Agents; D007097:Imines; D014230:Triazoles; C099741:1-(((5-nitro-2-furyl)methylene)amino)-1,2,4-triazole; D009547:Nifurtimox