Acute posterior multifocal placoid pigment epitheliopathy after acute group A streptococcal infection.
OBJECTIVE
We studied a case of acute posterior multifocal placoid pigment epitheliopathy in a 40-year-old man who had had an acute febrile illness.


METHODS
The medical record was reviewed for clinical manifestations, course of disease, and laboratory findings, including results of fluorescein and indocyanine green angiography.


RESULTS
The patient had the typical clinical course of acute posterior multifocal placoid pigment epitheliopathy with spontaneous resolution of posterior pole lesions and improvement in visual acuity from 20/60 to 20/20. The laboratory evaluation was remarkable for a rise in the anti-DNAse B antibody titer between initial and convalescent-phase serum samples, providing evidence of recent group A streptococcal infection.


CONCLUSIONS
Although acute posterior multifocal placoid pigment epitheliopathy is often attributed to a postviral condition, this syndrome may also develop after an acute group A streptococcal infection.
Lowder
C Y
CY
Division of Ophthalmology, Cleveland Clinic Foundation, USA.
Foster
R E
RE
Gordon
S M
SM
Gutman
F A
FA
D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003851:Deoxyribonucleases / Q000276:immunology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D010857:Pigment Epithelium of Eye / Q000276:immunology / Q000473:pathology*; D012164:Retinal Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013290:Streptococcal Infections / Q000150:complications* / Q000276:immunology; D013297:Streptococcus pyogenes / Q000201:enzymology
D001323:Autoantibodies; D003851:Deoxyribonucleases; C020069:deoxyribonuclease B; D007208:Indocyanine Green