title: Detection of respiratory syncytial virus (RSV) antigen in the lungs of guinea pigs 6 weeks after experimental infection and despite of the production of neutralizing antibodies.
abstract: Infections with respiratory syncytial virus (RSV) are characterized by frequently occurring reinfections and are regarded to be responsible for bronchial hyperreactivity. In this report we describe a small-animal model suited to study RSV-induced pathogenesis and immune response. Guinea pigs are infected by inhalation of an RSV-aerosol. Lungs of infected animals show signs of a bronchiolitis at 7 days after the initial infection. Although neutralizing serum antibodies are synthesized viral proteins are still detectable at 6 weeks post infection. Therefore, the presence of neutralizing antibodies is obviously not sufficient for rapid clearance of persistent RSV-proteins from the lungs of infected guinea pigs.
authors.affiliation: Department of Medical Microbiology and Virology, Ruhr-University, Bochum, Federal Republic of Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Streckert
authors.forename: S
authors.initials: S
authors.lastname: Philippou
authors.forename: F
authors.initials: F
authors.lastname: Riedel
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis* / Q000276:immunology; D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D015707:HN Protein; D006801:Humans; D008168:Lung / Q000276:immunology* / Q000473:pathology / Q000821:virology; D009500:Neutralization Tests; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000276:immunology*; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D015707:HN Protein; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C116204:attachment protein G