In-vivo and in-vitro assessment of the influence of ritodrine and oxytocin on the placental secretion of human chorionic gonadotrophin and placental lactogen.
The purpose of this study was to evaluate, in vivo and in vitro, the influence of ritodrine and oxytocin on the placental release of human chorionic gonadotrophin (HCG) and placental lactogen (HPL). The in-vivo study was performed on maternal sera collected before and 1 h after the onset of either ritodrine treatment (50 micrograms i.v./min; administered to 15 women at risk of premature labour) or oxytocin infusion (2 mU i.v./min; administered to 21 women for acceleration of slow labour). The in-vitro study was performed on human term placental explants incubated in the presence of 4-400 ng ritodrine/ml or 15-1500 microU oxytocin/ml. HCG and HPL were measured by radioimmunoassay on maternal sera and incubation media. Maternal circulating concentrations of HCG and HPL remained unaffected after 1 h of ritodrine or oxytocin treatment. The in-vitro release of HCG and HPL by placental explants was not modified when ritodrine or oxytocin was added to the incubation media. The lack of influence of ritodrine and oxytocin on the placental secretion of HCG and HPL suggests that beta 2-adrenergic and oxytocin receptors are not involved in the releasing process.
Meuris
S
S
Research Laboratory on Reproduction, Free University of Brussels (ULB), Belgium.
Gavriil
P
P
Vanbellinghen
A M
AM
Delogne-Desnoeck
J
J
Robyn
C
C
Lebrun
P
P
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D006063:Chorionic Gonadotropin / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010121:Oxytocin / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism*; D010928:Placental Lactogen / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D018045:Receptors, Oxytocin / Q000378:metabolism; D012312:Ritodrine / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D006063:Chorionic Gonadotropin; D011943:Receptors, Adrenergic, beta; D018045:Receptors, Oxytocin; D010121:Oxytocin; D010928:Placental Lactogen; D012312:Ritodrine