title: [Clinical course and risk of fungal infections development in children with treated with chemo- and radiotherapy for solid tumors].
abstract: The authors estimated the incidence of mycotic infections among children patients with histological diagnosis of solid tumors during the period of neutropenia. Superficial mycoses including mucoses were observed in 35.3% of analysed patients, while a disseminated mycotic infections of a severe clinical course were seen in 2.9% neutropenic patients. Prophylactic administration of Diflucan (1-2 mg/kg/24h)(fluconazole) in neutropenic patients proved efficient in great majority of children, preventing the occurrence of severe mycotic complications.
authors.affiliation: I Klinika Chorób Dzieci Instytutu Pediatrii AMG.
authors.forename: A
authors.initials: A
authors.lastname: Balcerska
authors.forename: E
authors.initials: E
authors.lastname: Drozyńska
authors.forename: J
authors.initials: J
authors.lastname: Stefanowicz
authors.forename: E
authors.initials: E
authors.lastname: Bień
authors.forename: E
authors.initials: E
authors.lastname: Szutowicz
authors.forename: P
authors.initials: P
authors.lastname: Czarniak
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D009181:Mycoses / Q000209:etiology* / Q000517:prevention & control; D009447:Neuroblastoma / Q000150:complications; D009503:Neutropenia / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000532:radiotherapy; D009396:Wilms Tumor / Q000150:complications
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole
vernacular_title: Obraz kliniczny i ryzyko rozwoju zakazeń grzybiczych u dzieci poddawanych chemio- i radioterapii z powodu złośliwych guzów litych.