title: Regional localization of over 300 loci on human chromosome 22 using a somatic cell hybrid mapping panel.
abstract: A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or "bins" using this panel. This ordered collection of markers will aid in the assembly of physical maps and contigs of chromosome 22 and assist in positional cloning of disease loci mapped to chromosome 22.
authors.affiliation: Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Budarf
authors.forename: B
authors.initials: B
authors.lastname: Eckman
authors.forename: D
authors.initials: D
authors.lastname: Michaud
authors.forename: T
authors.initials: T
authors.lastname: McDonald
authors.forename: S
authors.initials: S
authors.lastname: Gavigan
authors.forename: K H
authors.initials: KH
authors.lastname: Buetow
authors.forename: Y
authors.initials: Y
authors.lastname: Tatsumura
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Hilliard
authors.forename: D
authors.initials: D
authors.lastname: Driscoll
authors.forename: E
authors.initials: E
authors.lastname: Goldmuntz
authors.forename: E
authors.initials: E
authors.lastname: Meese
authors.forename: E C
authors.initials: EC
authors.lastname: Zwarthoff
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: H
authors.initials: H
authors.lastname: McDermid
authors.forename: J P
authors.initials: JP
authors.lastname: Dumanski
authors.forename: J
authors.initials: J
authors.lastname: Biegel
authors.forename: C J
authors.initials: CJ
authors.lastname: Bell
authors.forename: B S
authors.initials: BS
authors.lastname: Emanuel
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006224:Cricetinae; D017931:DNA Primers; D015342:DNA Probes; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005819:Genetic Markers; D005821:Genetic Techniques; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D015342:DNA Probes; D005819:Genetic Markers