title: [Giant cell fibroblastoma. A rare soft tissue tumor in childhood].
abstract: We report on a 9-year-old girl with a giant cell fibroblastoma of the right anterior chest wall. This rare soft tissue tumour occurs predominantly in the first two decades of life. The typical clinical presentation is a solitary, usually 2-6 cm large, non-tender mass of blue-greyish colour which is mostly located on the back, anterior chest wall, thigh or groin. The histology shows a loose infiltrate of predominantly bland spindle cells in dermis and subcutis. Characteristic elements of the tumour are large angiectoid branching spaces lacking any endo- or epithelium, and relatively small multinucleated cells (floret cells). The recurrence rate is high if the tumour is not excised with adequate safety margins. Metastases are not reported. It is of pre-eminent importance to differentiate this rare benign tumor from sarcomas, in order to avoid an inappropriately aggressive therapy.
authors.affiliation: Hautklinik, Universität, Wurzburg.
authors.forename: B C
authors.initials: BC
authors.lastname: Bastian
authors.forename: D
authors.initials: D
authors.lastname: Harms
authors.forename: H H
authors.initials: HH
authors.lastname: Kreipe
authors.forename: H
authors.initials: H
authors.lastname: Hamm
authors.forename: E B
authors.initials: EB
authors.lastname: Bröcker
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002648:Child; D003238:Connective Tissue / Q000473:pathology; D018223:Dermatofibrosarcoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Das Riesenzellfibroblastom. Ein seltener Weichteiltumor des Kindesalters.