title: Antimutagenic effects of polyphenols isolated from Terminalia bellerica myroblan in Salmonella typhimurium.
abstract: Antimutagenic effect of 2 polyphenolic fractions isolated from T. bellerica in TA98 and TA100 strains of S. typhimurium against 2AF, NPD and 4NQNO has been characterized. Both the fractions were significantly effective against S9-dependent 2AF; less effective against NPD and almost not effective against 4NQNO in TA100 strain. Using 13C-NMR spectral analysis, the TB-3 fraction, which was significantly more effective against 2AF compared to TB-4, was found to be a mixture of 3 tannins while TB-4 was non-tannin fraction. Interaction of polyphenols with S9 proteins may be the probable cause of inhibitory effect of these polyphenols, though the possibility of other mechanisms cannot be ruled out.
authors.affiliation: Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Padam
authors.forename: I S
authors.initials: IS
authors.lastname: Grover
authors.forename: M
authors.initials: M
authors.lastname: Singh
mesh_terms: D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids; D005638:Fruit / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D012486:Salmonella typhimurium / Q000187:drug effects*; D013045:Species Specificity
chemical_list: D016587:Antimutagenic Agents; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols