A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas.
The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T-lymphoma-bearing F2 mice, 45 had the AKR-derived dominant allele at Tism-1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh-derived recessive gene was named lla (lymphoma latency acceleration).
Kamoto
T
T
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan.
Shisa
H
H
Pataer
A
A
Lu
L
L
Yoshida
O
O
Yamada
Y
Y
Hiai
H
H
D000483:Alleles; D000818:Animals; D004276:DNA, Satellite / Q000235:genetics; D008040:Genetic Linkage; D005838:Genotype; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic
D004276:DNA, Satellite; D000949:Histocompatibility Antigens Class II