title: A pyrazoline derivative of eunicin acetate.
abstract: The present crystal structure determination established spiro [¿3a,4,5,6,7,8,11,12,13,14,15,15a-dodecahydro-6,10,14-trimet hyl-2-oxo-5, 15-epoxy-3H-cyclotetradeca-[b]furan¿-3,3'-1'-pyrazoline]-6-yl acetate, C23H34N2O5, as a pyrazoline derivative of eunicin acetate. The spiro substitution of the pyrazoline ring causes elongation of the bonds within the lactone ring and also shortening of the carbonyl bond. The cembranolide skeleton is slightly more bent than that observed in the parent eunicin molecule.
authors.affiliation: Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
authors.forename: S
authors.initials: S
authors.lastname: Khalil
authors.forename: M B
authors.initials: MB
authors.lastname: Hossain
authors.forename: D
authors.initials: D
authors.lastname: van der Helm
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: R
authors.initials: R
authors.lastname: Sanduja
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D011720:Pyrazoles; D013141:Spiro Compounds; C099740:spiro((3a,4,5,6,7,8,11,12,13,14,15,15a-dodecahydro-6,10,14-trimethyl-2-oxo-5,15-epoxy-3H-cyclotetradeca(b)furan)-3,3'-1'-pyrazoline)-6-yl acetate