Inactivated bovine herpesvirus 1 induces apoptotic cell death of mitogen-stimulated bovine peripheral blood mononuclear cells.
Bovine herpesvirus 1 (BHV-1) is able to inhibit the proliferation of bovine peripheral blood mononuclear cells. Here, we have demonstrated that live BHV-1 and, interestingly, inactivated BHV-1 can induce apoptosis of mitogen-stimulated bovine peripheral blood mononuclear cells in vitro.
Hanon
E
E
Department of Immunology/Vaccinology, Faculty of Veterinary Medicine, University of Liège, Belgium. hanon@stat.fmv.ulg.ac.be
Vanderplasschen
A
A
Lyaku
S
S
Keil
G
G
Denis
M
M
Pastoret
P P
PP
D000818:Animals; D017209:Apoptosis; D002417:Cattle; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D007242:Herpesvirus 1, Bovine / Q000502:physiology*; D015759:Ionomycin / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D014764:Viral Proteins / Q000032:analysis
D014764:Viral Proteins; D015240:Phorbol 12,13-Dibutyrate; D015759:Ionomycin; D004247:DNA