[Production of type I interferons in the body exposed to yeast RNA-tiloron molecular complexes].
Molecular complexes forming as a result of interaction between yeast RNA preparations with 2,7-bis[-(diethylaminoethoxy)-fluorene]-9-on dihydrochloride (tilorone) administered parenterally to mice cause the appearance of interferon in high titers compatible to those induced by standard inductors of polyribonucleotide origin, poly(I)-poly(C) and larifan. Some physiologic conditions of interferonogenesis have been studied. The above molecular complexes in the dose range used experimentally were completely nontoxic. Hence, these complexes are promising agents for interferon induction.
Karpov
A V
AV
Zholobak
N M
NM
D000818:Animals; D007369:Interferon Inducers / Q000737:chemistry / Q000494:pharmacology*; D007370:Interferon Type I / Q000096:biosynthesis*; D051379:Mice; D009930:Organic Chemicals; D011070:Poly I-C / Q000494:pharmacology; D012331:RNA, Fungal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013994:Tilorone / Q000737:chemistry / Q000494:pharmacology*
D007369:Interferon Inducers; D007370:Interferon Type I; D009930:Organic Chemicals; D012331:RNA, Fungal; C066530:larifan; D013994:Tilorone; D011070:Poly I-C
Produktsiia interferonov I tipa v organizme pod deĭstviem molekuliarnykh kompleksov drozhzhevaia RNK-tiloron.