Amphotericin B responsive Scedosporium apiospermum infection in a patient with acute myeloid leukaemia.
A 71 year old man with newly diagnosed acute myelomonocytic leukaemia developed a soft tissue infection of his foot during his first course of chemotherapy. Scedosporium apiospermum was isolated from the lesion, which resolved rapidly on treatment with intravenous amphotericin B despite being resistant in vitro to this agent. This observation suggests that sensitivity testing of S apiospermum should be interpreted with caution and that clinical response may be a better indicator of outcome.
Cunningham
R
R
Department of Microbiology, Derby Royal Infirmary.
Mitchell
D C
DC
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications; D008297:Male; D008271:Mycetoma / Q000150:complications / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D011541:Pseudallescheria / Q000187:drug effects*
D000935:Antifungal Agents; D000666:Amphotericin B