title: [Rational approach to correction of intestinal microflora].
abstract: This paper reviews the present notions of the mechanisms of probiotics' action and analyzes selective approaches to correcting the intestinal microflora, such as the use of antibiotic-resistant and highly-adhesive probiotics, treatment with autostrains of lactobacilli and bifidobacteria, and the application of fermented-milk probiotics. Methods for optimization of the intestinal microflora in the newborns by using the maternal strains of bifidobacteria and the drug Zlemik that contains highly-adhesive lactobacilli are discussed. It is shown that parameters of immunotropic activity and involvement in the bacteriocin-mediated interactions may be used to design new probiotics. In future, the application of gene engineering methods will aid in designing a new generation of probiotics with predicted biological properties.
authors.forename: V M
authors.initials: VM
authors.lastname: Korshunov
authors.forename: V V
authors.initials: VV
authors.lastname: Smeianov
authors.forename: B A
authors.initials: BA
authors.lastname: Efimov
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001430:Bacteriocins; D001644:Bifidobacterium / Q000254:growth & development / Q000502:physiology; D005260:Female; D005818:Genetic Engineering; D006801:Humans; D007231:Infant, Newborn; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D007778:Lactobacillus / Q000254:growth & development / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001430:Bacteriocins
vernacular_title: Ratsional'nye podkhody k probleme korrektsii mikroflory kishechnika.