Intravenous immunoglobulin treatment of pregnant patients with unexplained recurrent abortions.
Intravenous immunoglobulins, first given to recurrent aborters with anti-phospholipid syndrome, have been administered to unexplained aborters since 1986. They probably have immunomodulatory properties beyond supplying blocking antibodies. When pregnancy was confirmed, women were started with a loading dose which was repeated every 3-4 weeks until the second trimester. Dosages were empirical. Pregnancy rates ranged between 50 and 82%. The main maternal complications, i.e. allergic reactions and infections, were rare.
Raziel
A
A
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Sackler School of Medicine, Israel.
Herman
A
A
Bukovsky
I
I
Caspi
E
E
Ron-el
R
R
D000026:Abortion, Habitual / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy
D016756:Immunoglobulins, Intravenous