Effect of Spirulina maxima consumption on reproduction and peri- and postnatal development in rats.
Spirulina maxima, an edible micro-organism useful in human nutrition, was examined for its effect on general reproductive performance and for peri- and postnatal toxicity in rats at levels of 0, 10, 20 and 30% (w/w) incorporated into the diet. There was no reduction in body weight gain in males or females and no deaths or clinical signs of toxicity. Treatment was not associated with any adverse effect on any measure of reproductive performance, including male and female fertility and duration of gestation. There was no increase in the number of abnormal pups at caesarean section or at birth. S. maxima consumption did not result in adverse effects on developmental markers of the pups.
Salazar
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M
Department of Toxicology, National School of Biological Sciences, National Polytechnic Institute, Mexico City.
Chamorro
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GA
Salazar
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S
Steele
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CE
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001835:Body Weight; D000458:Cyanobacteria; D004032:Diet / Q000009:adverse effects*; D005260:Female; D005298:Fertility; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction