title: Uptake of desflurane during anaesthesia.
abstract: The amount of desflurane required to maintain an end-expired concentration of 8% was measured in 30 ASA 1 and 2 patients undergoing elective spinal surgery. The anaesthetic was administered using a computer-controlled closed circle system. After an initial period during which the expired concentration of desflurane was stabilised (4 min) the rate of uptake showed a bi-exponential decline. Mean cumulative usage of desflurane was 10.1 ml of liquid at 30 min, 14.8 ml at 60 min, 25.4 ml at 120 min, 35.8 at 180 min.
authors.affiliation: Department of Anaesthesia, Hammersmith Hospital, London.
authors.forename: T J
authors.initials: TJ
authors.lastname: Walker
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
mesh_terms: D000764:Anesthesia, Closed-Circuit; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D001944:Breath Tests; D000077335:Desflurane; D017558:Elective Surgical Procedures; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008875:Middle Aged; D013122:Spinal Diseases / Q000601:surgery
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane