title: Neurotrophins and their receptors in chicken neuronal development.
abstract: A review on current studies of chicken neurotrophins and their receptors is given. Chicken NGF, BDNF and NT-3 have been cloned and sequences have been used to synthesize oligonucleotides for specific localization of expression during development. Also, chicken TrkA, TrkB and TrkC have been cloned, sequenced and studied by in situ hybridization. Recombinant NT-3 was applied to chicken ganglia at different developmental stages to examine acquirement of responsiveness to NT-3 compared to NGF. Phylogenetic analyses of the chicken neurotrophins and Trk receptors were carried out based on parsimony. Finally, some data on apoptosis in chicken embryo sympathetic ganglia are presented.
authors.affiliation: Department of Developmental Neuroscience, Uppsala University, Biomedial Center, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Hallbook
authors.forename: A
authors.initials: A
authors.lastname: Bäckström
authors.forename: K
authors.initials: K
authors.lastname: Kullander
authors.forename: A
authors.initials: A
authors.lastname: Kylberg
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: T
authors.initials: T
authors.lastname: Ebendal
mesh_terms: D000818:Animals; D017209:Apoptosis; D019208:Brain-Derived Neurotrophic Factor; D002642:Chick Embryo / Q000502:physiology*; D005724:Ganglia / Q000187:drug effects / Q000196:embryology; D005728:Ganglia, Sympathetic / Q000196:embryology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008322:Mammals; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000494:pharmacology / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D020933:Neurotrophin 3; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis; D020801:Receptor, Ciliary Neurotrophic Factor; D020917:Receptor, trkA / Q000096:biosynthesis; D020812:Receptor, trkC; D017475:Receptors, Nerve Growth Factor / Q000096:biosynthesis* / Q000502:physiology; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000494:pharmacology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3; D020801:Receptor, Ciliary Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor; D011994:Recombinant Proteins; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA; D020812:Receptor, trkC