title: A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin.
abstract: A full-length cDNA encoding a human homolog of the approx. 110-kDa subunit (elongin A; El A) of the RNA polymerase II transcription factor, elongin, was isolated and sequenced. Comparison of the open reading frames of the human el A cDNA and the previously characterized rat El A cDNA [Aso et al., Science 269 (1995) 1439-1443] indicates that they are 84% conserved in nucleotide sequence and encode 84% identical proteins.
authors.affiliation: Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
authors.forename: T
authors.initials: T
authors.lastname: Aso
authors.forename: D
authors.initials: D
authors.lastname: Haque
authors.forename: K
authors.initials: K
authors.lastname: Fukudome
authors.forename: C S
authors.initials: CS
authors.lastname: Brower
authors.forename: J W
authors.initials: JW
authors.lastname: Conaway
authors.forename: R C
authors.initials: RC
authors.lastname: Conaway
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D017931:DNA Primers; D018076:DNA, Complementary; D000075065:Elongin; D015723:Gene Library; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D008970:Molecular Weight; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D012319:RNA Polymerase II / Q000378:metabolism*; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D017931:DNA Primers; D018076:DNA, Complementary; C000616397:ELOA protein, human; C000616404:Eloa protein, rat; D000075065:Elongin; D046911:Macromolecular Substances; D011994:Recombinant Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II