Inhibitory effects of some steroidal saponins on human spermatozoa in vitro.
Twenty-nine C-27 steroidal saponins were tested for the inhibitory effects on human spermatozoa in vitro by means of a modified Sander-Cramer method. Twelve of them are responsible for this activity. The structure-activity relationship is discussed.
Wang
Y F
YF
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
Li
X C
XC
Yang
H Y
HY
Wang
J J
JJ
Yang
C R
CR
D006801:Humans; D008297:Male; D010944:Plants; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D012503:Saponins; D013256:Steroids