[Critical analysis of controlled pharmacologic studies in obsessive compulsive disorder].
Controlled pharmacologic studies in obsessive-compulsive disorder (OCD) are recent, scare and concern only antidepressants. Clomipramine constitutes the reference drug in the treatment of OCD and in comparative studies. The present paper includes a compendium of the results of 15 controlled studies and a critical approach of their methodologies and conclusions. The discussion continues about the genuine anti-obsessive effect of antidepressants, its specificity and the underlying neurochemical mechanisms.
Brochier
T
T
Service de Pédopsychiatrie, Hôpital de la Fondation Vallée, Gentilly.
Hantouche
E
E
D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
D000928:Antidepressive Agents; D002997:Clomipramine; D011619:Psychotropic Drugs; D017367:Selective Serotonin Reuptake Inhibitors
Analyse critique des études pharmacologiques contrôlées dans le trouble obsessionnel-compulsif.