A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin.
A full-length cDNA encoding a human homolog of the approx. 110-kDa subunit (elongin A; El A) of the RNA polymerase II transcription factor, elongin, was isolated and sequenced. Comparison of the open reading frames of the human el A cDNA and the previously characterized rat El A cDNA [Aso et al., Science 269 (1995) 1439-1443] indicates that they are 84% conserved in nucleotide sequence and encode 84% identical proteins.
Aso
T
T
Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Haque
D
D
Fukudome
K
K
Brower
C S
CS
Conaway
J W
JW
Conaway
R C
RC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D017931:DNA Primers; D018076:DNA, Complementary; D000075065:Elongin; D015723:Gene Library; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D008970:Molecular Weight; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D012319:RNA Polymerase II / Q000378:metabolism*; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
D017931:DNA Primers; D018076:DNA, Complementary; C000616397:ELOA protein, human; C000616404:Eloa protein, rat; D000075065:Elongin; D046911:Macromolecular Substances; D011994:Recombinant Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II