title: Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.
abstract: We examined the distribution of several relevant growth factors in gamma-interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-alpha, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-alpha, and the EGF receptor were observed in acini undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.
authors.affiliation: Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: M
authors.initials: M
authors.lastname: Arnush
authors.forename: D
authors.initials: D
authors.lastname: Gu
authors.forename: C
authors.initials: C
authors.lastname: Baugh
authors.forename: S P
authors.initials: SP
authors.lastname: Sawyer
authors.forename: B
authors.initials: B
authors.lastname: Mroczkowski
authors.forename: T
authors.initials: T
authors.lastname: Krahl
authors.forename: N
authors.initials: N
authors.lastname: Sarvetnick
mesh_terms: D000818:Animals; D006133:Growth Substances / Q000737:chemistry / Q000502:physiology*; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D010179:Pancreas / Q000737:chemistry* / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects / Q000235:genetics*
chemical_list: D006133:Growth Substances; D007371:Interferon-gamma