title: Long-term comparative trial of glibenclamide and chlorpropamide in diet-failed, maturity-onset diabetics.
abstract: The long-term clinical effectiveness of glibenclamide was compared with chlorpropamide in highly comparable groups of three hundred and twenty-one diet-failed, non-obese, maturity-onset, newly diagnosed diabetics. The overall primary failure-rate in the chlorpropamide-treated patients was significantly less (p<0.05), and more patients were on chlorpropamide at the end of two years than were on glibenclamide (p<0.01). Although there were fewer secondary failures with chlorpropamide treatment, this difference was not significant. The final blood-glucose and change in body-weight were similar in patients from both treatment groups still taking the original sulphonylurea agent 2 years later. Hypoglycaemic episodes were more common and severe in the glibenclamide-treated patients.
authors.forename: B F
authors.initials: BF
authors.lastname: Clarke
authors.forename: I W
authors.initials: IW
authors.lastname: Campbell
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002747:Chlorpropamide / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005905:Glyburide / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D001786:Blood Glucose; D005905:Glyburide; D002747:Chlorpropamide