title: Atypical retinal astrocytic hamartoma diagnosed by fine-needle biopsy.
abstract: BACKGROUND
  Retinal astrocytic hamartoma and retinoblastoma may be very similar clinically, and their differentiation in atypical cases can be difficult, even with the use of ancillary methods such as fluorescein angiography, ultrasonography, and computed tomography. To the authors knowledge, fine-needle aspiration biopsy has not been used to diagnose astrocytic hamartoma in such cases.
  
  
  METHODS
  A 7-week-old boy had a minimally calcified retinal mass in the macular area of the left eye associated with an extensive secondary retinal detachment. The differential diagnosis included retinal astrocytic hamartoma and retinoblastoma. A transvitreal fine-needle aspiration biopsy was performed.
  
  
  RESULTS
  The cytology of the needle biopsy showed benign spindle and stellate cells, which were compatible with glial cells. The lesion had immunoreactivity for glial fibrillary acidic protein, further supporting the diagnosis of astrocytic tumor.
  
  
  CONCLUSIONS
  Fine-needle aspiration biopsy is diagnostically useful in unusual cases where the differential diagnosis between retinoblastoma and astrocytic hamartoma is difficult.
authors.affiliation: Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: H
authors.initials: H
authors.lastname: Ehya
authors.forename: E
authors.initials: E
authors.lastname: Buckley
authors.forename: P
authors.initials: P
authors.lastname: De Potter
mesh_terms: D001253:Astrocytes / Q000473:pathology*; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005124:Eye Abnormalities / Q000150:complications / Q000175:diagnosis*; D005134:Eye Neoplasms / Q000175:diagnosis; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006222:Hamartoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D012160:Retina / Q000002:abnormalities* / Q000473:pathology; D012163:Retinal Detachment / Q000209:etiology; D012175:Retinoblastoma / Q000175:diagnosis