title: Interoceptive sensory signals produced by 24-hr food deprivation, pharmacological glucoprivation, and lipoprivation.
abstract: The energy antimetabolites 2-deoxy-D-glucose (2-DG) and Na-2-mercaptoacetate (MA) both reliably augment food intake in rats. The present research was designed to assess if they also give rise to interoceptive cues like 24-hr food deprivation. Rats were first trained to discriminate a mild shock based on interoceptive cues arising from 1- and 24-hr food deprivation. They were then tested for generalized control of conditioned responding to interoceptive cues produced by 2-DG, MA, and saline. Results suggest that 2-DG (350 mg/kg) produces interoceptive sensory cues like those following 24-hr food deprivation. Further, no evidence was found to suggest that MA, either alone or in combination with 2-DG (100 mg/kg), produces interoceptive cues like 2-DG or 24-hr food deprivation.
authors.affiliation: Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA. scbenoit@psych.purdue.edu
authors.forename: S C
authors.initials: SC
authors.lastname: Benoit
authors.forename: T L
authors.initials: TL
authors.lastname: Davidson
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001245:Association Learning / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D003214:Conditioning, Classical / Q000187:drug effects*; D003847:Deoxyglucose / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005227:Fatty Acids / Q000097:blood; D005247:Feeding Behavior / Q000187:drug effects; D005508:Food Deprivation / Q000502:physiology*; D006815:Hunger / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D009042:Motivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013864:Thioglycolates / Q000494:pharmacology*; D014163:Transfer, Psychology
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D008055:Lipids; D013864:Thioglycolates; C017487:2-mercaptoacetate; D003847:Deoxyglucose