FISH localization of the soluble thymidine kinase gene (TK1) to human 17q25, a region of chromosomal loss in sporadic breast tumors.
Soluble thymidine kinase (TK1) is an important 17q marker in somatic cell genetics. Its activity is increased in many malignancies, including breast cancer. Through somatic cell hybrid and fluorescence in situ hybridization studies, we mapped TK1 to 17q25.2-->25.3, in region demonstrating loss of heterozygosity in primary breast tumors. It lies near D17S836 and is proximal to the avian erythroblastic leukemia viral oncogene homolog 2-like gene (ERBA2L).
Petty
E M
EM
Department of Internal Medicine, University of Michigan, Ann Arbor, USA. epetty@mmg.im.umich.edu
Miller
D E
DE
Grant
A L
AL
Collins
E E
EE
Glover
T W
TW
Law
D J
DJ
D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics* / Q000648:ultrastructure; D003001:Cloning, Molecular; D005260:Female; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D016133:Polymerase Chain Reaction; D013937:Thymidine Kinase / Q000235:genetics*
D005819:Genetic Markers; D013937:Thymidine Kinase; C092717:thymidine kinase 1