Ordering of the human regulator of complement activation gene cluster on 1q32 by two-colour FISH.
The regulator of complement activation (RCA) gene cluster and PTPRC and REN genes have been mapped to the 1q31-->q32 band interval. We have used two-colour in situ hybridization to determine the chromosomal position of these genes. We report here that HF1/F13B are proximal to the C4BP/MCP genes. We also propose that PTPRC and REN genes map to a region of the RCA gene cluster between the HF1/F13B and C4BP/MCP regions. In summary, we propose the following gene order: centromere-HF1/F13B-PTPRC-REN-C4BP/MCP-telomere.
Pardo-Manuel de Villena
F
F
Departamento de Immunologia, Centro de Investigaciones Biologicas (CSIC), Madrid, Spain.
Heine-Suñer
D
D
Rodriguez de Cordoba
S
S
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics* / Q000648:ultrastructure; D003167:Complement Activation / Q000235:genetics*; D005809:Genes, Regulator; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015335:Molecular Probes; D005810:Multigene Family
D015335:Molecular Probes