Novel spirodihydrobenzofuranlactams as antagonists of endothelin and as inhibitors of HIV-1 protease produced by Stachybotrys sp. II. Structure determination.
Roggo
B E
BE
Core Drug Discovery Technologies, Pharmaceutical Division, Ciba-Geigy Limited, Basel, Switzerland.
Hug
P
P
Moss
S
S
Stämpfli
A
A
Kriemler
H P
HP
Peter
H H
HH
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry*; D016232:Endothelins / Q000037:antagonists & inhibitors*; D016333:HIV Protease; D017320:HIV Protease Inhibitors / Q000737:chemistry*; D007769:Lactams; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013141:Spiro Compounds / Q000737:chemistry*; D013191:Stachybotrys / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001572:Benzofurans; D016232:Endothelins; D017320:HIV Protease Inhibitors; D007769:Lactams; D013141:Spiro Compounds; C088505:Mer NF5003E; D016333:HIV Protease