The frequency of venous thrombosis in cemented and non-cemented hip arthroplasty.
We randomised 250 patients undergoing unilateral, elective hip arthroplasty for osteoarthritis to receive either a cemented or a non-cemented Mallory Head prosthesis. Aspirin was used as prophylaxis against thromboembolism during the first half of the study and adjusted-dose warfarin during the second half. Postoperatively, all patients were asked to have bilateral venography and 80% agreed. All were evaluated clinically for pulmonary embolism. There was no difference in the frequency of deep-venous thrombosis between the two groups (50% cemented nu 47% non-cemented, p = 0.73; 95% CI of the difference -13.6% to 19.3%). Three of the 64 patients (5%) in whom venography had demonstrated isolated distal thrombi developed pulmonary emboli.
Laupacis
A
A
Division of General Medicine, Department of Medicine, Ottawa General Hospital, Ontario, Canada.
Rorabeck
C
C
Bourne
R
R
Tugwell
P
P
Bullas
R
R
Rankin
R
R
Vellet
A D
AD
Feeny
D
D
Wong
C
C
D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006622:Hip Prosthesis / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D010690:Phlebography; D011655:Pulmonary Embolism / Q000175:diagnosis; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000517:prevention & control
D000925:Anticoagulants; D001241:Aspirin