title: Increased numbers of interleukin-12-producing cells in human tuberculosis.
abstract: Numbers of interleukin-12 (IL-12) producing cells were quantitated in the peripheral blood of healthy donors and tuberculosis patients by the ELISPOT assay. We observed that (i) stimulation with mycobacteria increases numbers of IL-12 producers from healthy donors and (ii) tuberculosis patients have larger numbers of IL-12 producers than healthy donors. Our data emphasize the importance of Il-12 in immunity to tuberculosis.
authors.affiliation: Department of Immunology, University of Ulm, Germany.
authors.forename: M E
authors.initials: ME
authors.lastname: Munk
authors.forename: P
authors.initials: P
authors.lastname: Mayer
authors.forename: P
authors.initials: P
authors.lastname: Anding
authors.forename: K
authors.initials: K
authors.lastname: Feldmann
authors.forename: S H
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000328:Adult; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D018664:Interleukin-12 / Q000096:biosynthesis*; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D018664:Interleukin-12; D007371:Interferon-gamma