Nocturnal monitoring of growth hormone, insulin, C-peptide, and glucose in patients with acromegaly.
Circulating growth hormone, insulin, C-peptide, and glucose levels were compared during the sleep state in adults with acromegaly and healthy control subjects. Growth hormone secretion was episodic in both groups, with the sleep-related growth hormone peak noticeably absent in the acromegalic subjects. The mean nocturnal plasma insulin concentration was greater in the acromegalics. There was no significant difference in the C-peptide between the two groups. Insulin and glucose levels did not show an early morning rise in either acromegalics or healthy subjects. The authors conclude that there is a marked difference in the circulating levels of growth hormone and insulin between the acromegalic and the healthy groups during the sleep state, and there is no sleep-related nocturnal growth hormone peak in the acromegalic subjects. The hyperinsulinism of patients with acromegaly cannot be attributed to excess secretion of insulin.
Tsai
J S
JS
Department of Medicine, New York University Medical Center, New York, New York 10016, USA.
Zorrilla
L L
LL
Jacob
K K
KK
Rosenberg
S
S
Marcus
D L
DL
D000172:Acromegaly / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D005215:Fasting / Q000502:physiology; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology / Q000503:physiopathology; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D012636:Secretory Rate; D012890:Sleep / Q000502:physiology
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D013006:Growth Hormone