title: Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.
abstract: Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
authors.affiliation: Department of Biological Sciences, Kyoto University Faculty of Medicine, Kyoto 606, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yokoi
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Manabe
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: I
authors.initials: I
authors.lastname: Sakaguchi
authors.forename: G
authors.initials: G
authors.lastname: Katsuura
authors.forename: R
authors.initials: R
authors.lastname: Shigemoto
authors.forename: H
authors.initials: H
authors.lastname: Ohishi
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Nakao
authors.forename: M
authors.initials: M
authors.lastname: Katsuki
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003521:Cyclopropanes / Q000494:pharmacology; D004558:Electric Stimulation; D018390:Gene Targeting; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D018782:Maze Learning; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity; D017966:Pyramidal Cells / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D003521:Cyclopropanes; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C082313:2-(2,3-dicarboxycyclopropyl)glycine; D005998:Glycine