Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs.
CD1 proteins have been implicated as antigen-presenting molecules for T cell-mediated immune responses, but their intracellular localization and trafficking remain uncharacterized. CD1b, a member of this family that presents microbial lipid antigens of exogenous origin, was found to localize to endocytic compartments that included the same specialized subset of endosomes in which major histocompatibility complex (MHC) class II molecules are proposed to bind endocytosed antigens. Unlike MHC class II molecules, which traffic to antigen-loading endosomal compartments [MHC class II compartments (MIICs)] primarily as a consequence of their association with the invariant chain, localization of CD1b to these compartments was dependent on a tyrosine-based motif in its own cytoplasmic tail.
Sugita
M
M
Lymphocyte Biology Section, Division of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jackman
R M
RM
van Donselaar
E
E
Behar
S M
SM
Rogers
R A
RA
Peters
P J
PJ
Brenner
M B
MB
Porcelli
S A
SA
D000595:Amino Acid Sequence; D018949:Antigens, CD1 / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D001402:B-Lymphocytes; D001483:Base Sequence; D002451:Cell Compartmentation; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D003034:Coated Pits, Cell-Membrane / Q000276:immunology; D004705:Endocytosis; D011992:Endosomes / Q000276:immunology* / Q000648:ultrastructure; D006681:HLA-D Antigens / Q000032:analysis; D006367:HeLa Cells; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D016253:Microscopy, Immunoelectron; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology; D014162:Transfection
D018949:Antigens, CD1; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II