The regulation of AP-1 activity by mitogen-activated protein kinases.
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.
Karin
M
M
Department of Pharmacology, University of California, San Diego School of Medicine, La Jolla 92093, USA.
D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D018808:Transcription Factor AP-1 / Q000502:physiology*
D018808:Transcription Factor AP-1; D017871:Calcium-Calmodulin-Dependent Protein Kinases