Sleep problems in children with Sanfilippo syndrome.
Sanfilippo syndrome is a rare degenerative disorder which has severe intellectual and behavioural sequelae, commonly including sleep problems. A parental questionnaire was used to gather information on the sleep patterns of 80 children with Sanfilippo syndrome (mean age 10 years 2 months). The majority were found to have sleep problems (78%). Many also exhibited other distressing and unusual night time behaviours (staying up all night, chewing the bedclothes or crying out suddenly), and a few laughed or sang. Such problems may have been more severe in those with Sanfilippo syndrome type B. In four of the families offered individually tailored behaviour-management advice there was immediate improvement, which was maintained at followup in two cases. These results demonstrate the usefulness of even such a minimal intervention, even in a very difficult population such as this.
Colville
G A
GA
Department of Child Psychology and Psychiatry, St George's Hospital, London, UK.
Watters
J P
JP
Yule
W
W
Bax
M
M
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009084:Mucopolysaccharidosis III / Q000145:classification / Q000150:complications*; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000628:therapy; D011795:Surveys and Questionnaires; D013997:Time Factors