Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury.
Cefuroxime levels were measured in cerebrospinal fluid (CSF) and serum of four patients with traumatic brain injury following the implantation of intraventricular catheters. The levels ranged from 0.15 to 2.03 micrograms/mL in CSF and from 1.8 to 66.9 micrograms/mL in serum. No ventriculostomy related infections were detected.
Kossmann
T
T
Department of Surgery, University of Zürich, Medical School, Switzerland.
Hans
V
V
Stocker
R
R
Imhof
H G
HG
Joos
B
B
Trentz
O
O
Morganti-Kossmann
M C
MC
D000293:Adolescent; D000328:Adult; D019072:Antibiotic Prophylaxis; D001812:Blood-Brain Barrier; D001930:Brain Injuries / Q000134:cerebrospinal fluid*; D002444:Cefuroxime / Q000134:cerebrospinal fluid*; D002511:Cephalosporins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male
D002511:Cephalosporins; D002444:Cefuroxime