title: Behavioral effects of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome).
abstract: The behavioral effects of felbamate were assessed in 20 persons, (ages 2 to 19 years) who were participating in a compassionate plea protocol for children with Lennox-Gastaut syndrome. Parents completed a questionnaire concerning aspects of behavioral change once all medications were in a constant regimen. Significant improvements were suggested in social functioning, intellectual functioning, motor functioning, attention and concentration, alertness, initiative, variability in performance, and memory. There was a tendency for these effects to reverse when the drug was discontinued.
authors.affiliation: Department of Psychology, Westminster College, Salt Lake City, Utah 84106, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Gay
authors.forename: G F
authors.initials: GF
authors.lastname: Mecham
authors.forename: J S
authors.initials: JS
authors.lastname: Coskey
authors.forename: T
authors.initials: T
authors.lastname: Sadler
authors.forename: J A
authors.initials: JA
authors.lastname: Thompson
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D001925:Brain Damage, Chronic / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy* / Q000523:psychology; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology; D000078328:Felbamate; D005260:Female; D006801:Humans; D008297:Male; D010552:Personality Assessment; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000009:adverse effects / Q000627:therapeutic use*; D012919:Social Behavior; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate