Skeletal response to immobilization in Paget's disease of bone: a case report.
The authors discuss a case of Paget's disease of the forearm in which the Pagetic radius and non-Pagetic ulna responded differently to immobilization. The high turnover state of Pagetic bone is more sensitive to physical unloading than normal bone, and thus more rapidly develops osteopenia of immobilization. The different responses to immobilization between Pagetic bone and site controlled normal bone illustrate how physical and metabolic factors interact at a skeletal site to regulate bone remodeling and bone mass.
Wallace
K
K
Department of Medicine (Division of Endocrinology), The University of Pennsylvania School of Medicine, Phildelphia, PA, USA.
Haddad
J G
JG
Gannon
F H
FH
Esterhai
J
J
Kaplan
F S
FS
D016723:Bone Remodeling; D006801:Humans; D007103:Immobilization; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D011859:Radiography; D011885:Radius Fractures / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*