Anticlastogenic effects of galangin against mitomycin C-induced micronuclei in reticulocytes of mice.
We investigated the suppressive effect of galangin on the induction of micronucleated reticulocytes (MNRETs) by mitomycin C (MMC) in mouse peripheral blood. When galangin was given to mice 24 h before the intraperitoneal injection of MMC (1 mg/kg), a more marked decrease in the frequency of MNRETs was observed than in mice with simultaneous and post-treatment of galangin. On the other hand, when galangin was given to mice for 7 consecutive days before MMC injection, galangin showed potent anticlastogenic effects, even at the lowest dose level of 0.1 mg/kg. Results from our in vivo studies indicate that galangin is capable of suppressing the clastogenic activity of the direct acting MMC. Together with our earlier observations, it appears that galangin is capable of protecting cells from the toxic effects of a variety of hazardous chemicals. Therefore, galangin may be an useful chemopreventive compound.
Heo
M Y
MY
College of Pharmacy, Kangweon National University, Chuncheon, South Korea.
Jae
L H
LH
Jung
S S
SS
Au
W W
WW
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests; D016685:Mitomycin / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity; D012156:Reticulocytes / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D016587:Antimutagenic Agents; D005419:Flavonoids; D009153:Mutagens; C037032:galangin; D016685:Mitomycin