Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome.
The membrane protein CD63, a molecular marker for early stages of melanoma progression, has been associated with platelet storage pool deficiency disorders (SPD). CD63 localizes to the membranes of platelets, lysosomes, and melanosomes, all of which are affected in a specific subgroup of SPD. The cDNA encoding CD63 detects two closely related sequences that map to different regions of the mouse genome. One locus maps to mouse Chromosome (Chr) 10 in a region that shares linkage homology with the human chromosome encoding human CD63. The second locus maps to mouse Chr 18 in a region that bears no known human CD63-related genes. No SPD has been localized to these regions of either the mouse or the human chromosomes.
Gwynn
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The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609, USA.
Eicher
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Peters
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D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics; D018076:DNA, Complementary; D018450:Disease Progression; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009115:Muridae; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics*; D010981:Platelet Storage Pool Deficiency / Q000235:genetics; D051381:Rats; D015183:Restriction Mapping; D060149:Tetraspanin 30
D015703:Antigens, CD; C554586:CD63 protein, human; C554587:Cd63 protein, mouse; D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D005819:Genetic Markers; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30