Hemophilia 1996. New approach to an old disease.
The history of hemophilia diagnosis and therapy has been a turbulent one. We are coming full circle, back to the use of genetics as the main diagnostic tool for this disease. Therapeutically, the retroviruses that ravaged one generation of hemophiliac patients now may participate in the cure for the next generation. The hemophilia community hopes that the future of hemophilia care will follow a course guided by this modified quote from James Russell Lowell: "New times demand new measures, and men [and women]. As the world advances and in time outgrows the laws that in our fathers' [and mothers'] days were the best, doubtless after us some purer scheme will be shaped out by wiser men [and women] than we, made wiser by the steady growth of truth."
DiMichele
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Regional Comprehensive Hemophilia Diagnostic and Treatment Center, New York Hospital-Cornell Medical Center, New York.
D001779:Blood Coagulation Factors / Q000627:therapeutic use; D018076:DNA, Complementary; D005164:Factor IX / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D015316:Genetic Therapy; D006467:Hemophilia A / Q000175:diagnosis* / Q000266:history / Q000628:therapy*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008297:Male; D017354:Point Mutation; D011296:Prenatal Diagnosis; D014960:X Chromosome
D001779:Blood Coagulation Factors; D018076:DNA, Complementary; C025667:prothrombin complex concentrates; D005169:Factor VIII; D005164:Factor IX