The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.
p12I is a small hydrophobic protein encoded by the human T-cell leukemia/lymphotropic virus type 1 (HTLV-1) that interacts with the 16-kDa component of the H+ vacuolar ATPase and cooperates with bovine papillomavirus 1 E5 oncoprotein in cell transformation. Just as an important step in E5 action appears to be its binding to the platelet-derived growth factor receptor, it was found that p12I binds specifically to both the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R). The IL-2R beta and gamma(c) chains associated with p12I are endoglycosidase-H sensitive, suggesting that their interaction occurs in a pre-Golgi compartment. p12I stabilizes the immature forms of the IL-2R beta and gamma(c) chains and decreases their cell surface expression. The interactions of p12I with IL-2R beta and gamma(c) may have important implications in the immunosuppressive effect of HTLV-1 in vivo as well as in the ligand-independent HTLV-1-mediated T-cell proliferation.
Mulloy
J C
JC
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
Crownley
R W
RW
Fullen
J
J
Leonard
W J
WJ
Franchini
G
G
D006056:Golgi Apparatus / Q000378:metabolism; D015490:HTLV-I Infections / Q000276:immunology; D006367:HeLa Cells; D015368:Human T-lymphotropic virus 1 / Q000737:chemistry*; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000378:metabolism*; D012191:Retroviridae Proteins / Q000378:metabolism*
D015375:Receptors, Interleukin-2; D012191:Retroviridae Proteins