title: Cutaneous ulcerations and pustular psoriasis flare caused by recombinant interferon beta injections in patients with multiple sclerosis.
abstract: Seven patients with multiple sclerosis who were receiving subcutaneous injections of recombinant interferon beta had pain followed by ulceration at the injection site. An eighth patient had a pustular flare of her usually mild psoriasis. No evidence of infection or contaminated medication was found.
authors.affiliation: Department of Dermatology, Jefferson Medical College, Philadelphia, USA.
authors.forename: G F
authors.initials: GF
authors.lastname: Webster
authors.forename: R L
authors.initials: RL
authors.lastname: Knobler
authors.forename: F D
authors.initials: FD
authors.lastname: Lublin
authors.forename: E M
authors.initials: EM
authors.lastname: Kramer
authors.forename: L R
authors.initials: LR
authors.lastname: Hochman
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000628:therapy*; D011565:Psoriasis / Q000209:etiology* / Q000473:pathology; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D000068576:Interferon beta-1b; D016899:Interferon-beta; D000068556:Interferon beta-1a