title: [Preparation and antiviral properties of Bacillus intermedius ribonuclease modified by chloranhydride of adamantanecarboxylic acid].
abstract: Bacillus intermedius ribonuclease modified by the residue of adamantane carboxylic acid was prepared. When the cells of chick embryo fibroblasts infected by the fowl plague virus were exposed to the modified ribonuclease, the antiviral activity proved to be higher by comparison to that of the native enzyme. The chemotherapeutic index of the RNAse after the modification increased 4 times.
authors.forename: B M
authors.initials: BM
authors.lastname: Kurinenko
authors.forename: N V
authors.initials: NV
authors.lastname: Kalacheva
authors.forename: P Iu
authors.initials: PIu
authors.lastname: Muratov
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology*; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D015394:Molecular Structure; D012260:Ribonucleases / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; C012698:adamantanecarboxylic acid; D012260:Ribonucleases; D000218:Adamantane
vernacular_title: Poluchenie i protivovirusnye svoĭstva ribonukleazy "Bacillus intermedius", modifitsirovannoĭ khlorangidridom adamantankarbonovoĭ kisloty.