The intestinal tract and the pathophysiology of arterial hypertension: an experimental study on Dahl rats.
Salt depleted rabbits and humans excrete an oral sodium load more quickly via the kidneys than an intravenous one. This has been ascribed to the presence of a sodium sensor in the gastrointestinal tract which in some way can influence renal function. The purpose of this study was to investigate this response in the Dahl rats. Renal and faecal sodium excretion was followed in the two strains of rats (normotensive, saltresistant (SR/Jr) and hypertensive, saltsensitive (SS/Jr) rats). After 4 days on a low salt diet they were given NaCl (1.5 mmol k(-1) body wt) either by gavage or intravenously. SR/Jr rats showed an increased renal sodium excretion both after oral and intravenous sodium repletion. The excretion was 2-3 times greater after th oral than after the intravenous administration. The SS/Jr rats augmented their renal sodium excretion only after the oral load, although the sodium excretion was significantly less than in SR/Jr rats. In fact, during the first 8 h after giving sodium orally the renal excretion of sodium was on an average eight times larger in the SR/Jr than in the SS/Jr rats. Renal excretion of sodium was similar in the two strains after intravenous administration. We conclude that the hypertensive SS/Jr rats have great difficulties in excreting an oral sodium load, a phenomenon that may be of importance in the pathophysiology of arterial hypertension in this strain of rats.
Mu
J Y
JY
Department of Physiology, University of Göteborg, Gothenburg, Sweden.
Hansson
G C
GC
Lundgren
O
O
D000818:Animals; D004039:Diet, Sodium-Restricted; D004064:Digestive System / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009318:Natriuresis / Q000502:physiology; D009994:Osmolar Concentration; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D012965:Sodium Chloride / Q000008:administration & dosage; D014556:Urine
D012965:Sodium Chloride; D012964:Sodium; D011188:Potassium