title: [The problem of systemic mutation].
abstract: The problems of the rearrangement of genome architecture during speciation are considered. The history of the problem of the role of systemic mutations in evolution is analyzed. The author's own phenomenological data on the spatial rearrangement of the chromosomal apparatus of germline tissue (that is regarded as systemic mutations) during the phylogeny of a number of dipterous insects are systematized. A concept on the essence of systemic mutations and their crucial role in saltatory transformation of genomes in the course of species evolution is advanced.
authors.forename: V N
authors.initials: VN
authors.lastname: Stegniĭ
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004175:Diptera / Q000235:genetics; D015321:Gene Rearrangement; D005828:Genetics, Population; D016678:Genome; D009154:Mutation; D010802:Phylogeny
vernacular_title: Problema sistemnykh mutatsiĭ.