Augmentation of CD8 and CD4 lymphocytes subsets in AIDS infected children after treatment with a non-toxic chelating agents compound--Rodilemid.
Twelve children were included into the protocol, 5 in March 1989 and 7 in April 1993. All of them were HIV 1 positive and had diarrhoea, important adenopathy and opportunistic infections. Seven out of 12 patients had an immunological monitoring. One out of 12 children with B hepatitis died with liver cirrhosis. Eleven children had a clear improvement in their clinical course, during the treatment. Five out of 7 patients had a significant increase of the CD4 lymphocytes at 4 and 7 months follow-up. Four patients had an important and significant increase of the CD8 count at 4 months and 6 out of 7 patients at 7 months. Interestingly, in 4 out of 7 patients after 7 months treatment we observed higher than normal value of the CD8 count. Variations observed for CD8 population compared to CD4 were more important.
Dinu
R
R
Outhospital No. 1, Bucharest, Romania.
Moraru
I
I
State
D
D
Dinu
I
I
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology*; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio / Q000187:drug effects*; D002125:Calcium Gluconate / Q000009:adverse effects / Q000627:therapeutic use*; D002614:Chelating Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D003545:Cysteine / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D004492:Edetic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D007223:Infant; D013997:Time Factors
D000998:Antiviral Agents; D002614:Chelating Agents; D004338:Drug Combinations; C044148:rodilemid; D004492:Edetic Acid; D003545:Cysteine; D002125:Calcium Gluconate