Element- and isotope-specific detection for high-performance liquid chromatography using chemical reaction interface mass spectrometry.
We have developed a combination of high-performance liquid chromatography (HPLC) and the chemical reaction interface mass spectrometry (CRIMS) method by using a Vestec Universal Interface (UI). This interface provides the extremely high degree of solvent removal that the CRIMS process requires. In doing so, we have produced an HPLC detector with the ability to carry out the element- and isotope-selective analyses with detection that is inherently: linear, structure-independent, sensitive, selective, comprehensive and flexible. The characteristics of the instrumentation and its performance are described.
McLean
M
M
PerSeptive Biosystems, Vestec Mass Spectrometry Products, Houston, TX 77054, USA.
Vestal
M L
ML
Teffera
Y
Y
Abramson
F P
FP
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*