title: [Controlled hypotension against a background of nimodipine during an operation on neurosurgical patients with hypertension].
abstract: Operative interventions in subarachnoid hemorrhages caused by brain vessel aneurysm require meticulous dissection of the latter. Regardless of the preoperative preparation of hypertensives, hypertension is a factor predisposing to intraoperative blood pressure fluctuation which, in turn, is extremely unfavourable and interferes with the operation proper on the aneurysm. What is more, it augments the spasm of cerebral vessels and brain edema. Any increase in blood pressure may result in a rupture of the aneurysm. As shown by a parallel study on two groups of patients with hypertension, following intraoperative administration of calcium antagonists having a preventive effect on brain, the stabilization of blood pressure attained is persistent, with the spasm of cerebral vessels and brain edema lending themselves more readily to control. The application of controlled hypotension is more easily effected, and administration of ganglioblocking agents is unnecessary.
authors.forename: D
authors.initials: D
authors.lastname: Karadimov
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D007023:Hypotension, Controlled / Q000379:methods*; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D007430:Intraoperative Care / Q000379:methods*; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use*; D011229:Preanesthetic Medication; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*
chemical_list: D000959:Antihypertensive Agents; D009553:Nimodipine
vernacular_title: Kontrolirana khipotoniia na fona na nimodipin pri operirane na nevrokhirurgichno bolni s khipertoniia.