title: [Diode laser coagulation of stage 3+ retinopathy of prematurity].
abstract: BACKGROUND
  Laser photocoagulation in retinopathy of prematurity (ROP) appears to have fewer adverse effects and to be at least as effective as cryotherapy.
  
  
  METHODS
  To evaluate the efficacy and safety of diode laser photocoagulation we examined 50 eyes affected by stage 3+ ROP in 30 very low birth weight infants (gestational age 24-29 weeks, mean +/- SD 26.5 +/- 1.4 weeks; birth weight 480-1400 g, 898 +/- 208 g) in a prospective (uncontrolled) clinical study. Photocoagulation treatment was performed using a diode laser (810 nm) with a laser indirect ophthalmoscope delivery system. Follow-up ranged from 3 to 23 months (10.5 +/- 6.4 months).
  
  
  RESULTS
  In 46 (92%) of the 50 eyes ROP regressed after a single laser treatment and the outcome was a flat, attached retina. Two eyes (4%) had a second laser session and one other eye (2%) had additional retinal detachment surgery, resulting in the regression of ROP and a flat, attached retina. Thus, the success rate was 98% (49 out of 50 eyes). In 1 (2%) of the 50 eyes treatment failed and ROP progressed to stage 5, although additional retinal detachment surgery was performed. No adverse side effects of diode laser treatment were noted, except for a small amount of retinal/preretinal bleeding in the ridge in 8 eyes (16%) and slight postoperative anterior chamber bleeding in 1 eye (2%) with dense tunica vasculosa lentis. There were neither lenticular opacities nor cataract formation.
  
  
  CONCLUSIONS
  Diode laser photo coagulation using the laser indirect ophthalmoscope for stage 3+ ROP was easy to administer. Laser treatment had only minor side effects and was at least as effective as cryotherapy.
authors.affiliation: Universitäts-Augenklinik, Klinikum Mannheim.
authors.forename: V
authors.initials: V
authors.lastname: Seiberth
authors.forename: O
authors.initials: O
authors.lastname: Linderkamp
authors.forename: I
authors.initials: I
authors.lastname: Vardarli
authors.forename: M C
authors.initials: MC
authors.lastname: Knorz
authors.forename: H
authors.initials: H
authors.lastname: Liesenhoff
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D017075:Laser Coagulation / Q000295:instrumentation*; D008297:Male; D019721:Ophthalmoscopes; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D012086:Reoperation; D012178:Retinopathy of Prematurity / Q000145:classification / Q000601:surgery*; D016896:Treatment Outcome
vernacular_title: Diodenlaserkoagulation der Retinopathia praematurorum Stadium 3+.