title: Ophthalmic cyclosporine in equine keratitis and keratouveitis: 11 cases.
abstract: Topical cyclosporine A was safely used in a series of 11 cases of equine keratitis and keratouveitis and appeared to be an effective anti-inflammatory agent in 9 cases. The clinical diagnoses included interstitial keratouveitis, endotheliitis, multifocal punctate keratopathy and a melting stromal ulcer. In most cases, the presence or absence of insidious bacterial infection was not conclusively determined. Topical cyclosporine A had no deleterious effects in this series of cases. The authors suggest that topical cyclosporine in both aqueous and lipid base vehicles should be investigated and evaluated as an alternative mode of achieving ocular immunosuppression.
authors.affiliation: Department of Small Animal Medicine, University of Georgia, Athens 30602, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Gratzek
authors.forename: R L
authors.initials: RL
authors.lastname: Kaswan
authors.forename: C L
authors.initials: CL
authors.lastname: Martin
authors.forename: E S
authors.initials: ES
authors.lastname: Champagne
authors.forename: S L
authors.initials: SL
authors.lastname: White
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D003320:Corneal Ulcer / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary; D006734:Horse Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006736:Horses; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine