title: Amphotericin B responsive Scedosporium apiospermum infection in a patient with acute myeloid leukaemia.
abstract: A 71 year old man with newly diagnosed acute myelomonocytic leukaemia developed a soft tissue infection of his foot during his first course of chemotherapy. Scedosporium apiospermum was isolated from the lesion, which resolved rapidly on treatment with intravenous amphotericin B despite being resistant in vitro to this agent. This observation suggests that sensitivity testing of S apiospermum should be interpreted with caution and that clinical response may be a better indicator of outcome.
authors.affiliation: Department of Microbiology, Derby Royal Infirmary.
authors.forename: R
authors.initials: R
authors.lastname: Cunningham
authors.forename: D C
authors.initials: DC
authors.lastname: Mitchell
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications; D008297:Male; D008271:Mycetoma / Q000150:complications / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D011541:Pseudallescheria / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B