title: Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature.
abstract: Collagen disease are frequently associated with malignant tumors. Recently, radiotherapy combined with chemotherapy has been recommended for improving the efficacy of treatment for nasopharyngeal carcinoma. Two patients with nasopharyngeal carcinoma complicated by collagen diseases (dermatomyositis in one, and Sjögren's syndrome with mixed connective tissue disease in the other) were given radiotherapy combined with chemotherapy consisting of cis-platinum and 5-fluorouracil. Following this combination therapy, both patients developed retropharyngeal abscess and ulceration of the mucosal membrane on the posterior wall of the oropharynx; there was no tumor cell involvement. Because these injuries were more severe than would have been expected from radiotherapy alone, it is recommended that special attention be paid to combination therapy in patients with nasopharyngeal carcinoma complicated by collagen disease.
authors.affiliation: Department of Radiology, Sapporo Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hareyama
authors.forename: H
authors.initials: H
authors.lastname: Nagakura
authors.forename: M
authors.initials: M
authors.lastname: Tamakawa
authors.forename: K
authors.initials: K
authors.lastname: Hyodo
authors.forename: K
authors.initials: K
authors.lastname: Asakura
authors.forename: T
authors.initials: T
authors.lastname: Horikoshi
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: A
authors.initials: A
authors.lastname: Hattori
authors.forename: A
authors.initials: A
authors.lastname: Oouchi
authors.forename: M
authors.initials: M
authors.lastname: Shido
authors.forename: H
authors.initials: H
authors.lastname: Koshiba
authors.forename: K
authors.initials: K
authors.lastname: Sakata
authors.forename: K
authors.initials: K
authors.lastname: Morita
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003095:Collagen Diseases / Q000150:complications*; D003131:Combined Modality Therapy; D005260:Female; D005402:Fistula / Q000209:etiology; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000628:therapy*; D010608:Pharyngeal Diseases / Q000209:etiology; D010614:Pharynx / Q000528:radiation effects; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects; D017703:Retropharyngeal Abscess / Q000209:etiology*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil