title: The frequency of venous thrombosis in cemented and non-cemented hip arthroplasty.
abstract: We randomised 250 patients undergoing unilateral, elective hip arthroplasty for osteoarthritis to receive either a cemented or a non-cemented Mallory Head prosthesis. Aspirin was used as prophylaxis against thromboembolism during the first half of the study and adjusted-dose warfarin during the second half. Postoperatively, all patients were asked to have bilateral venography and 80% agreed. All were evaluated clinically for pulmonary embolism. There was no difference in the frequency of deep-venous thrombosis between the two groups (50% cemented nu 47% non-cemented, p = 0.73; 95% CI of the difference -13.6% to 19.3%). Three of the 64 patients (5%) in whom venography had demonstrated isolated distal thrombi developed pulmonary emboli.
authors.affiliation: Division of General Medicine, Department of Medicine, Ottawa General Hospital, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Laupacis
authors.forename: C
authors.initials: C
authors.lastname: Rorabeck
authors.forename: R
authors.initials: R
authors.lastname: Bourne
authors.forename: P
authors.initials: P
authors.lastname: Tugwell
authors.forename: R
authors.initials: R
authors.lastname: Bullas
authors.forename: R
authors.initials: R
authors.lastname: Rankin
authors.forename: A D
authors.initials: AD
authors.lastname: Vellet
authors.forename: D
authors.initials: D
authors.lastname: Feeny
authors.forename: C
authors.initials: C
authors.lastname: Wong
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006622:Hip Prosthesis / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D010690:Phlebography; D011655:Pulmonary Embolism / Q000175:diagnosis; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D001241:Aspirin