title: Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction.
abstract: The inflammatory cytokines interleukin 1 (IL1) and tumour necrosis factor (TNF) have a broad range of physiological effects. Whereas their immediate post-receptor events are not well understood, both have the potential to activate a range of protein kinases. These include the three types of mitogen activated protein (MAP) kinase (ERK, JNK/p54 and p38) and a beta-casein kinase. The mechanisms by which these kinases are activated is discussed and the significance of their activation for particular biological responses is assessed.
authors.affiliation: Department of Development and Signalling, Babraham Institute, Cambridge, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Saklatvala
authors.forename: W
authors.initials: W
authors.lastname: Davis
authors.forename: F
authors.initials: F
authors.lastname: Guesdon
mesh_terms: D007375:Interleukin-1 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha