title: High-dose administration of nonionic contrast media: a retrospective review.
abstract: OBJECTIVE
  To assess the safety of high-dose nonionic contrast media (CM) during a single radiologic procedure.
  
  
  METHODS
  From November 1991 to August 1995, 255 high-dose angiographic procedures were performed in 228 patients with normal serum creatinine (SCr) levels (< or = 1.6 mg/dL [141 mumol/L]). All patients received 250-800 mL low-osmolarity CM (300 mg iodine per milliliter). Pre- and postprocedure SCr levels were assessed. Urine output was measured daily in the 75 patients who received more than 400 mL CM. With linear regression analysis, a dose-related elevation in SCr levels was calculated.
  
  
  RESULTS
  No patient developed abnormal SCr levels (> 1.6 mg/dL [141 mumol/L]) as a result of the CM. Among the patients who received more than 400 mL, none developed oliguria over the first 36 hours. With follow-up up to 3 years, no patient experienced delayed clinical renal failure. In 11 (4.3%) patients, the SCr levels increased more than 25%, but all increases were within expected limits (chi 2 analysis). Linear regression analysis revealed a 0.015 mg/dL (1 mumol/L) increase in SCr levels per 100 mL CM.
  
  
  CONCLUSIONS
  Intravenous administration of high-dose low-osmolarity iodinated CM appears safe in patients without renal dysfunction or other underlying risk factors, in doses as large as 800 mL (300 mg iodine per milliliter).
authors.affiliation: Department of Neuroradiology, New York University Medical Center, NY 10016, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Rosovsky
authors.forename: H
authors.initials: H
authors.lastname: Rusinek
authors.forename: A
authors.initials: A
authors.lastname: Berenstein
authors.forename: S
authors.initials: S
authors.lastname: Basak
authors.forename: A
authors.initials: A
authors.lastname: Setton
authors.forename: P K
authors.initials: PK
authors.lastname: Nelson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage* / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D003287:Contrast Media; D003404:Creatinine; D007479:Iopamidol