title: Mineral and nitrogen balance in lambs implanted with zeranol.
abstract: Fourteen crossbred wether lambs (average BW, 28 kg +/- 2.3) were either implanted (12 mg of zeranol) or not implanted and group-fed an 86% concentrate diet for 21 d. Lambs were then moved to metabolism stalls and fed .8 kg/d for a 10-d stall adjustment followed by a 7-d total collection of feces and urine. Feed, feces and urine were analyzed for Ca, P, Mg, Zn, Mn, Cu, and N. Apparent absorption of Mn, Cu, and N, were similar for implanted and nonimplanted lambs. Zeranol did not affect (P > .10) the retention of Mn or Cu. Zeranol decreased fecal excretion of CA 22% (P < .01), P 27% (P < .05), Mg 11% (P < .03) and Zn 9% (P < .10). This increased apparent absorption of CA 88% (P < .01), P 193% ( P < .05), Mg 9% (P < .05) and Zn 45% (P < .10) in zeranol-treated lambs. Urinary excretion of all nutrients analyzed was similar for implanted and control lambs with the exception of N, which was reduced by 24% (P < .06) in implanted lambs. The amount of Ca, Mg, and Zn retained increased 98% (P < .01), 138% (P < .03), and 60% (P < .10), respectively, in implanted lambs compared with controls. These results indicate that zeranol improved N balance and enhanced the absorption and retention of Ca, P, Mg, and Zn in lambs.
authors.affiliation: Texas A & M University System, College Station 77843, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Hufstedler
authors.forename: L W
authors.initials: LW
authors.lastname: Greene
mesh_terms: D000042:Absorption / Q000187:drug effects / Q000502:physiology; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002118:Calcium / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine; D003300:Copper / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine; D004343:Drug Implants; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D008274:Magnesium / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine; D008297:Male; D008345:Manganese / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine; D008903:Minerals / Q000378:metabolism* / Q000493:pharmacokinetics; D009584:Nitrogen / Q000032:analysis / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D010758:Phosphorus / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine; D012756:Sheep / Q000378:metabolism*; D015029:Zeranol / Q000008:administration & dosage / Q000494:pharmacology*; D015032:Zinc / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine
chemical_list: D004343:Drug Implants; D004968:Estrogens, Non-Steroidal; D008903:Minerals; D010758:Phosphorus; D008345:Manganese; D015029:Zeranol; D003300:Copper; D008274:Magnesium; D015032:Zinc; D009584:Nitrogen; D002118:Calcium