title: Monoclonal cryo-antifibrinogenemia.
abstract: We report on a 54-year-old female patient with arthritis and a severe cold-induced leukocytoclastic vasculitis of the skin caused by a rare form of cryofibrinogenemia ("type II" cryofibrinogen). Affinity chromatography of cryoprecipitates from the patient's plasma revealed reversible cryoprecipitability of complexes composed of fibrinogen and a monoclonal antifibrinogen antibody (IgG3 kappa). Conventional serum and plasma electrophoresis did not detect the paraprotein. Control of symptoms was achieved by long-term plasmapheresis.
authors.affiliation: Christian-Albrecht University, Kiel, Germany.
authors.forename: H H
authors.initials: HH
authors.lastname: Euler
authors.forename: R A
authors.initials: RA
authors.lastname: Zeuner
authors.forename: R
authors.initials: R
authors.lastname: Béress
authors.forename: H J
authors.initials: HJ
authors.lastname: Gutschmidt
authors.forename: E
authors.initials: E
authors.lastname: Christophers
authors.forename: J O
authors.initials: JO
authors.lastname: Schroeder
mesh_terms: D003450:Cryoglobulins; D005260:Female; D005340:Fibrinogen; D015241:Fibrinogens, Abnormal; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000628:therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology* / Q000628:therapy
chemical_list: D003450:Cryoglobulins; D015241:Fibrinogens, Abnormal; D007074:Immunoglobulin G; C041874:cryofibrinogen; D005340:Fibrinogen