Controlling IGF-receptor function: a possible strategy for tumor therapy.
The insulin-like growth factor-1 receptor (IGF-IR) is one of several growth-factor receptors that regulate the proliferation of mammalian cells. However, its ubiquitousness and certain unique aspects of its function make IGF-IR an ideal target for therapeutic interventions against abnormal growth, with very little effect on normal cells.
Baserga
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Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. baserga1@jeflin.rju.edu
D000818:Animals; D001709:Biotechnology / Q000639:trends*; D015316:Genetic Therapy / Q000639:trends*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000628:therapy*; D017526:Receptor, IGF Type 1 / Q000502:physiology*
D017526:Receptor, IGF Type 1