title: Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBFalpha gene family.
abstract: We cloned the human cDNA corresponding to the cDNA (PEBP2alphaB-451) encoding the mouse polyomavirus enhancer-binding protein 2alphaB-451, representing a major splice variant from acute myeloid leukemia gene 1 (AML1). Genomic DNA clones of AML1 were also isolated and the exon/intron structure was determined. Furthermore, we determined and compared the genomic structures of three mammalian Runt domain-containing genes, PEBP2alphaA,AML/PEBE2alphaB and PEBP2alphaC.
authors.affiliation: Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan.
authors.forename: M Y
authors.initials: MY
authors.lastname: Ahn
authors.forename: S C
authors.initials: SC
authors.lastname: Bae
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000208:Acute Disease; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D050659:Core Binding Factor Alpha 1 Subunit; D050676:Core Binding Factor Alpha 2 Subunit; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D007438:Introns; D007951:Leukemia, Myeloid / Q000235:genetics*; D008322:Mammals; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics*; D011120:Polyomavirus / Q000235:genetics; D011518:Proto-Oncogene Proteins; D012689:Sequence Homology, Nucleic Acid; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; D050676:Core Binding Factor Alpha 2 Subunit; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; C493726:Runx1 protein, mouse; C493716:Runx2 protein, mouse; D050656:Transcription Factor AP-2; D014157:Transcription Factors