title: Increased uptake of indium-111 pentetreotide up to 10 years after external thoracic irradiation: report of two cases.
abstract: Indium-111 pentetreotide scintigraphy was performed in two patients for the localization of recurrent medullary thyroid carcinoma treated by surgery and external radiotherapy 1 and 10 years earlier. A marked uptake of the radiopharmaceutical was demonstrated in the lung areas that had been irradiated. These cases strongly suggest that this uptake is related to pulmonary fibrosis, a well-known complication of radiotherapy, even long after the irradiation. Therefore, attention must be paid to the avoidance of false-positive interpretation of somatostatin receptor scintigraphy in patients previously treated by radiotherapy.
authors.affiliation: Department of Nuclear Medicine, University of Louvain (UCL), Mont-Godinne, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Stoffel
authors.forename: F
authors.initials: F
authors.lastname: Jamar
authors.forename: J
authors.initials: J
authors.lastname: Donckier
authors.forename: P
authors.initials: P
authors.lastname: Hainaut
authors.forename: P
authors.initials: P
authors.lastname: Decoster
authors.forename: C
authors.initials: C
authors.lastname: Beckers
authors.forename: S
authors.initials: S
authors.lastname: Pauwels
mesh_terms: D000368:Aged; D018276:Carcinoma, Medullary / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D017564:Radiation Pneumonitis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D013997:Time Factors
chemical_list: D007205:Indium Radioisotopes; D013004:Somatostatin; C081788:pentetreotide