title: Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
abstract: The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells responded by expressing several activation markers and by growing, In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA+ gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.
authors.affiliation: Department of Cell and Molecular Biology, University of Umeå, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Lundgren
authors.forename: N
authors.initials: N
authors.lastname: Carballeira
authors.forename: R
authors.initials: R
authors.lastname: Vazquez
authors.forename: E
authors.initials: E
authors.lastname: Dubinina
authors.forename: H
authors.initials: H
authors.lastname: Bränden
authors.forename: H
authors.initials: H
authors.lastname: Persson
authors.forename: H
authors.initials: H
authors.lastname: Wolf-Watz
mesh_terms: D018829:Adhesins, Bacterial; D001402:B-Lymphocytes / Q000276:immunology*; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000502:physiology*; D006801:Humans; D019012:Integrin beta1 / Q000502:physiology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology; D015011:Yersinia pseudotuberculosis / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D019012:Integrin beta1; C053476:invasin, Yersinia