Effects of gallopamil on epinephrine and norepinephrine plasmatic levels and on TxB2 and beta-tg release in patients with coronary artery disease during adrenergic stimulus with cold pressor test.
We investigated the effect of gallopamil administration during a cold pressor test (CPT) in 18 patients suffering from chronic angina (CA) and in 21 healthy subjects. CA patients showed increased basal levels of beta-thromboglobulin and thromboxane B2 compared to control patients and normal plasma levels of catecholamines. CPT caused plasma catecholamines, beta-thromboglobulin and TxB2 levels to rise. This rise was greater in CA patients than in control patients. Administration of gallopamil (50 mg kg-1 three times a day for 30 days) reduced plasma levels of catecholamines, beta-thromboglobulin and TxB2 blood concentrations either under basal conditions or after CPT. Our data suggest that gallopamil is able to modulate the response induced by adrenergic stress.
Saitta
A
A
Department of Internal Medicine and Medical Therapeutics, University of Messina, Italy.
Bonaiuto
M
M
Mileto
A
A
Squadrito
F
F
Campo
G M
GM
Altavilla
D
D
Giordano
G
G
Squadrito
G
G
Totaro
S
S
Cinquegrani
M
M
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003080:Cold Temperature; D003327:Coronary Disease / Q000188:drug therapy; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005711:Gallopamil / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood*; D001620:beta-Thromboglobulin / Q000378:metabolism*
D002121:Calcium Channel Blockers; D001620:beta-Thromboglobulin; D005711:Gallopamil; D013929:Thromboxane B2; D009638:Norepinephrine; D004837:Epinephrine