Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors.
The ERM protein belongs to the family of Ets transcription factors. We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3'-untranslated region of ERM is 2.1 kb, whereas the 5'-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3.
Monté
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Unité d'Oncologie Moléculaire, CNRS URA 1160-Institut Pasteur de Lille, Lille Cedex, 59019, France.
Coutte
L
L
Dewitte
F
F
Defossez
P A
PA
Le Coniat
M
M
Stéhelin
D
D
Berger
R
R
de Launoit
Y
Y
D000595:Amino Acid Sequence; D001483:Base Sequence; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005796:Genes; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D005810:Multigene Family; D014157:Transcription Factors / Q000145:classification / Q000235:genetics*
D004268:DNA-Binding Proteins; C086680:ETV5 protein, human; D014157:Transcription Factors