[Cefminox versus cefotaxime in the treatment of complicated urinary tract infection].
A comparative study of Cefminox, a new cefamicin, and Cefotaxime was conducted to evaluate the efficacy and safety of the former in the treatment of complicated urinary infection, and to correlate in both cases the bacteriological response with isolates MICs. To this end a phase III, randomized, blind and controlled clinical trial was conducted in 22 patients who met the study's preestablished criteria, 19 of which were evaluable. Both treatments achieved 100% clinical efficacy, while microbiological eradication was accomplished in 90.9% patients treated with Cefminox and 75% patients who received the comparator. Cefminox shows greater in vivo activity than that expected for the MICs, excellent efficacy and safety.
Gastón de Iriarte
E
E
Servicio de Urología, Hospital La Paz, Facultad de Medicina, Universidad Autónoma, Madrid.
Cárcamo Valor
P
P
Diez-Enciso
M
M
Prieto Prieto
J
J
Pérez Balcabao
I
I
Gimeno del Sol
M
M
Coronel Granado
P
P
Morán Soto
M J
MJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002439:Cefotaxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002513:Cephamycins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D002511:Cephalosporins; D002513:Cephamycins; D002439:Cefotaxime; C046079:cefminox
Cefminox versus cefotaxima en el tratamiento de la infección urinaria complicada.