title: Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum.
abstract: Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 micrograms/ml.
authors.forename: W S
authors.initials: WS
authors.lastname: Sheen
authors.forename: I L
authors.initials: IL
authors.lastname: Tsai
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: F N
authors.initials: FN
authors.lastname: Ko
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D010946:Plants, Medicinal; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011799:Quinazolines / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013624:Taiwan; D013917:Thrombin / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D011799:Quinazolines; D016718:Arachidonic Acid; D003094:Collagen; D013917:Thrombin