[Decreased activity of oxidoreductases in erythrocytes and blood platelets from venous and umbilical blood of women with pregnancy-induced hypertension].
Thirty two pregnancies with pregnancy-induced hypertension (PIH) and twenty seven control normal pregnancies were analysed with regard to maternal and fetal blood enzymatic antioxidants. In PIH maternal erythrocyte, platelet and serum blood and in umbilical cord blood levels of lipid peroxides were higher than in normal pregnancy. Also the activities of platelet and erythrocyte superoxide dismutase and glutathione peroxidase were lower in PIH women. The concentration of lipid peroxides was higher, and the activity of glutathione peroxidase were lower in umbilical cord elements of women with PIH, than corresponding values of women with normal pregnancy. We suggest that disturbances in antioxidant enzymatic system are involved in the pathogenesis of maternal PIH, and it may also have effects on the function of antioxidant status of the fetus.
Jendryczko
A
A
Katedry i Zakładu Chemii i Analizy Leków, AM w Katowicach.
Tomala
J
J
D000328:Adult; D001792:Blood Platelets / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000201:enzymology*; D015227:Lipid Peroxidation / Q000502:physiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000201:enzymology*; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000097:blood*
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Zmniejszenie aktywności enzymów przeciwoksydacyjnych w erytrocytach i płytkach krwi zylnej i pepowinowej kobiet z nadciśnieniem indukowanym ciaza.