A role for glycoconjugates in human development: the human feto-embryonic defence system hypothesis.
The mechanisms underlying the protection of the human embryo/fetus from the maternal immune response are poorly understood. Substantial evidence indicates that carbohydrate recognition plays a primary role in the sequestration of leukocytes during inflammatory processes, lymphocyte homing, and initial gamete binding. Our previous studies suggest a possible convergence in the types of carbohydrate sequences recognized during initial human gamete binding and immune/inflammatory cell interactions. Our more recent findings indicate that oligosaccharides participating in such processes are also associated with soluble glycoconjugates found in the human placenta, amniotic fluid, and decidua. We theorize that such glycoconjugates may abrogate the maternal immune/inflammatory response by blocking the primary adhesive interactions required for the expression of such activities. Foreign embryonic cells may also be protected by surface expression of oligosaccharide sequences that suppress immune effector cell action in a manner not dependent upon classical major histocompatibility (MHC) recognition. Glycoconjugates expressing selectin ligands may also manifest a potent contraceptive effect that may also be beneficial for both the mother and the developing embryo/fetus. This hypothesis provides a preliminary framework for understanding how temporally and spatially restricted immunosuppressive effects could be expressed in utero that protect the human embryo/fetus during this period of human development.
Clark
G F
GF
Department of Biochemistry, Eastern Virginia Medical School, Norfolk 23501-1980, USA.
Oehninger
S
S
Patankar
M S
MS
Koistinen
R
R
Dell
A
A
Morris
H R
HR
Koistinen
H
H
Seppälä
M
M
D000818:Animals; D002240:Carbohydrate Sequence; D005314:Embryonic and Fetal Development / Q000276:immunology* / Q000502:physiology*; D005260:Female; D005306:Fertilization / Q000502:physiology; D006001:Glycoconjugates / Q000737:chemistry / Q000276:immunology* / Q000502:physiology*; D000071816:Glycodelin; D006023:Glycoproteins / Q000276:immunology / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D008969:Molecular Sequence Data; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology / Q000502:physiology; D011323:Primates
D006001:Glycoconjugates; D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins