Addition of rifampin to cephalexin therapy for recalcitrant staphylococcal skin infections--an observation.
We report two pediatric patients with recalcitrant staphylococcal infections whose infections resolved when rifampin was added to standard antistaphylococcal therapy. One patient had a post-varicella staphylococcal ulcerative lesion and did not respond to cephalexin alone but did respond when rifampin was added. A second patient had staphylococcal bullous impetigo and did not respond to dicloxacillin or cephalexin but did respond when rifampin was added to the cephalexin. If a patient fails to respond to traditional antistaphylococcal therapy, the addition of rifampin may be beneficial.
Feder
H M
HM
Department of Pediatrics, University of Connecticut Health Center, Farmington 06030-3960, USA.
Pond
K E
KE
D002506:Cephalexin / Q000627:therapeutic use*; D002644:Chickenpox / Q000150:complications; D002648:Child; D004359:Drug Therapy, Combination; D006229:Hand Dermatoses / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007169:Impetigo / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D011446:Prospective Studies; D012293:Rifampin / Q000627:therapeutic use*; D012874:Skin Diseases, Infectious / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology
D002506:Cephalexin; D012293:Rifampin