title: Iohexol clearance for GFR-determination in renal failure--single or multiple plasma sampling?
abstract: The present study examined the agreement between single and multiple sample plasma clearance of iohexol, a non-ionic contrast agent, in renal failure. Sixty-five patients with varying degree of renal insufficiency received 10 ml iohexol (300 mg I/ml) i.v. and plasma samples were collected four times during the following 3-24 h. Plasma-iodine concentrations were determined by X-ray fluorescence. Predicted creatinine clearance was used to choose one of the samples for determination of single sample clearance. A single plasma specimen collected at 4 h for GFR above 50 ml/min, at 7 h for GFR between 20 and 50 ml/min, and at 24 h for GFR below 20 ml/min gave values in good agreement with those based on a four sample slope clearance. No sign of nephrotoxicity was noted after administration of the contrast agent. It is concluded that single sample plasma clearance after single injection of iohexol gives a good estimate of GFR in renal failure and is advantageous in clinical practice.
authors.affiliation: Department of Vascular and Renal Diseases, University Hospital, Malmö, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Sterner
authors.forename: B
authors.initials: B
authors.lastname: Frennby
authors.forename: B
authors.initials: B
authors.lastname: Hultberg
authors.forename: T
authors.initials: T
authors.lastname: Almen
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007455:Iodine / Q000097:blood; D007472:Iohexol / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000097:blood / Q000378:metabolism*; D013052:Spectrometry, X-Ray Emission / Q000379:methods
chemical_list: D003287:Contrast Media; D007472:Iohexol; D007455:Iodine