title: [Poor prognosis in children with ultrasonographically diagnosed abnormalities of the central nervous system].
abstract: OBJECTIVE
  Long-term follow-up of children with a prenatally diagnosed malformation of the central nervous system.
  
  
  METHODS
  Descriptive study.
  
  
  METHODS
  Department of prenatal diagnosis, Academic Medical Center, Amsterdam, the Netherlands.
  
  
  METHODS
  Evaluation of all documented ultrasound examinations between 1985 and 1990 (6 years). These ultrasound examinations were performed in women with an increased risk for a foetal malformation, because of obstetrical complications or when a foetal malformation was suspected on ultrasound examination performed elsewhere. Paediatricians and general practitioners were asked to provide follow-up data on the children who were still alive.
  
  
  RESULTS
  Seven out of 67 foetuses with a prenatally diagnosed malformation of the central nervous system lived longer than one month. Two out of these 7 children developed normally, one child died after several years and four children were severely retarded. The two children who developed normally both had mild hydrocephaly.
  
  
  CONCLUSIONS
  Prognosis of children with a prenatally diagnosed malformation of the central nervous system is poor. Children with mild hydrocephaly may have a better prognosis.
authors.affiliation: Afd. Gynaecologie en Verloskunde, Academisch Medisch Centrum, Amsterdam.
authors.forename: T
authors.initials: T
authors.lastname: Mulder
authors.forename: K
authors.initials: K
authors.lastname: Boer
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: H A
authors.initials: HA
authors.lastname: Zondervan
authors.forename: J H
authors.initials: JH
authors.lastname: Kok
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000002:abnormalities*; D002657:Child Development; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011379:Prognosis; D016019:Survival Analysis; D016216:Ultrasonography, Prenatal
vernacular_title: Sombere prognose bij kinderen met prenataal echoscopisch vastgestelde afwijkingen van het centrale zenuwstelsel.