[Lipid peroxidation and LDL modifications in nondiabetic patients with ischemic heart disease: the role of insulin action].
BACKGROUND
Nondiabetic patients with advanced coronary artery disease (CAD) were assessed for lipid peroxidation, LDL modifications and insulin action. Twenty-four patients and 10 normal controls were studied.


METHODS
Insulin tolerance test (Kitt), glucose, insulin lipoproteins, electronegatively charged, modified, low density lipoproteins (LDL-) and the thiobarbituric acid reactivity (TBARS), as an index of lipid peroxidation, were determined.


RESULTS
No difference was observed in insulin action (determined by insulin tolerance test) between patients with CAD (3.31 +/- 0.28%/min; range 0.73-6.13) and normal controls (3.59 +/- 0.42; range 1.76-6.06). The percentage of modified, electronegative LDL (LDL -) was higher in patients with CAD (0.5 +/- 0.48%; range 1.3-9.2) than that of controls (2.80 +/- 0.33; range 1.00-4.00; p = 0.013). TBARS were significantly (P = 0.043) higher in CAD patients (3.49 +/- 0.17 nmol/ml; range 2.4-5.5) than normal controls (1.47 +/- 0.12; range 1.07-2.10). A significantly negative correlation was observed between Kitt and TBARS (r= - 0.48; p = 0.016), and a significant (r = 0.46; p = 0.022) positive correlation was observed between plasma glucose and TBARS. On the contrary no correlation has been observed between LDL- and TBARS.


CONCLUSIONS
We conclude that in patients with advanced coronary artery disease: A) there are increased circulating levels of modified low density lipoprotein; B) there is evidence of increased lipid peroxidation. This latter process is significantly influenced by the degree of insulin action.
Avogaro
A
A
Istituto di Medicina Clinica Dell'Universitatà di Padova.
Armigliato
M
M
Cazzolato
G
G
Caruso
N
N
Boffa
G
G
Bittolo Bon
G
G
Tiengo
A
A
D001786:Blood Glucose / Q000032:analysis; D003327:Coronary Disease / Q000097:blood / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000502:physiology; D007333:Insulin Resistance; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D001786:Blood Glucose; D007328:Insulin; D008077:Lipoproteins, LDL
Perossidazione lipidica e modificazioni delle LDL in pazienti non diabetici con cardiopatia ischemica: il ruolo dell'azione insulinica.