title: A case of bleeding requiring hospitalization that was likely caused by an interaction between warfarin and levamisole.
abstract: Warfarin is one of the most commonly used oral anticoagulants. Many medications have been shown to influence the prothrombin time in patients treated with warfarin by various mechanisms. We observed a major bleeding episode that resulted from a probable interaction between levamisole (Ergamisol), 5-fluorouracil, and warfarin. It is conceivable that many patients who are predisposed to thromboembolism because of cancer and surgery will be taking this combination of medications.
authors.affiliation: Tufts Medical School, Boston, Massachusetts, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Wehbe
authors.forename: J A
authors.initials: JA
authors.lastname: Warth
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects*; D004357:Drug Synergism; D005260:Female; D006417:Hematuria / Q000139:chemically induced*; D006760:Hospitalization; D006801:Humans; D007978:Levamisole / Q000009:adverse effects*; D008875:Middle Aged; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000276:Adjuvants, Immunologic; D000925:Anticoagulants; D007978:Levamisole; D014859:Warfarin