title: Myocardial perfusion abnormalities during low-dose dobutamine after coronary reperfusion can be demonstrated with intravenous perfluorocarbon-exposed sonicated dextrose albumin ultrasound contrast.
abstract: We measured background-subtracted peak myocardial videointensity (PMVI) in the left anterior descending and left circumflex perfusion zones in open-chest dogs after intravenous injection of perfluorocarbon-exposed sonicated dextrose albumin ultrasound contrast (PESDA) after reperfusion of a coronary occlusion. These measurements were repeated during low-dose dobutamine (LDD). The ratio of PMVI in the reperfused zone (RZ) compared with the adjacent normal zone (NZ) was measured at baseline and during LDD. Dogs with a >50% diameter residual stenosis were group I (n = 10), and those with <50% residual stenosis were group II (n = 13). Wall-thickening (WT) responses to LDD were not different between groups. Although the PMVI ratio (PMVI(RZ)/PMVI(NZ)) was the same in both groups at baseline, it decreased by >0.1 during LDD in 8 of 10 in group I compared with only 3 of 13 in group II dogs (p = 0.01). PMVI in the RZ increased by > or = 1.5 U in 12 of 13 group II dogs during LDD, but only in 3 of 10 group I dogs. Therefore, intravenous PESDA can be combined with WT responses to define both myocardial function and flow after reperfusion.
authors.affiliation: Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198-2265, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Porter
authors.forename: F
authors.initials: F
authors.lastname: Xie
authors.forename: A
authors.initials: A
authors.lastname: Kricsfeld
authors.forename: U
authors.initials: U
authors.lastname: Deligonul
authors.forename: K
authors.initials: K
authors.lastname: Kilzer
authors.forename: D
authors.initials: D
authors.lastname: Kricsfeld
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000418:Albumins / Q000008:administration & dosage; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D003326:Coronary Circulation; D004280:Dobutamine / Q000008:administration & dosage; D004285:Dogs; D005466:Fluorocarbons / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D007275:Injections, Intravenous; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D015425:Myocardial Reperfusion; D013010:Sonication; D014463:Ultrasonography
chemical_list: D000318:Adrenergic beta-Agonists; D000418:Albumins; D003287:Contrast Media; D005466:Fluorocarbons; D004280:Dobutamine; D005947:Glucose