Matched and mismatched unrelated donor bone marrow transplantation for juvenile chronic myeloid leukaemia.
Juvenile chronic myeloid leukaemia (JCML) is a rare haematological condition of childhood curable only by bone marrow transplantation (BMT). We report our experience using matched and mismatched unrelated donor BMT for JCML in five patients. Although the procedure is hazardous in terms of toxicity and relapse, two patients are alive and disease-free 28 and 49 months post BMT.
Chown
S R
SR
Bone Marrow Transplant Unit, Royal Hospital for Sick Children, Bristol.
Potter
M N
MN
Cornish
J
J
Goulden
P
P
Goulden
N
N
Pamphilon
D
D
Steward
C G
CG
Oakhill
A O
AO
D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome