Postsurgical changes of the breast that mimic inflammatory breast carcinoma.
OBJECTIVE
To characterize a clinical syndrome that occurs in some women who have undergone breast or axillary lymph node biopsy or partial mastectomy.


METHODS
Six case reports are presented, the clinical and histopathologic findings are described, and the implications for recognition of this entity are discussed.


RESULTS
Patients who had undergone partial mastectomy, breast biopsy, or axillary lymph node excision shortly thereafter had clinical signs (most notably, erythema and edema) suggestive of infectious mastitis or inflammatory breast cancer. Representative histologic sections of involved skin revealed dilated dermal vessels without specific evidence of infection or cancer. Although antibiotic therapy was generally ineffective, the clinical findings resolved with time (from 2 months to 1 year). This condition should be considered in the differential diagnosis when this circumscribed patient population has such intervention-related symptoms.


CONCLUSIONS
This clinical syndrome may mimic an infectious or neoplastic process, but we hypothesize that it is due to interruption of lymphatic vessels. Appropriate recognition may alter the use of antibiotic therapy or surgical intervention.
Loprinzi
C L
CL
Division of Medical Oncology, Mayo Clinic Rochester, Minnesota 55905, USA.
Okuno
Sh
Sh
Pisansky
T M
TM
Sterioff
S
S
Gaffey
T A
TA
Morton
R F
RF
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D001365:Axilla; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D008413:Mastitis / Q000175:diagnosis; D008875:Middle Aged; D011183:Postoperative Complications