[Effect of bisphosphonates (HEBP, CL2MBP) on the process of biological mineralization in fresh bone and bone tissue de novo as a result of experimental osteogenesis induction in guinea pigs].
It is known from the literature that bisphosphonates inhibit mineralization process in skeletal tissues. To study in vivo the effects of HEBP (etidronate) and Cl2MBP (clodronate) both on preexisting bone mineral as well as on the early stages of the mineralization process the experimental model of heterotopical bone induction was chosen. Urinary bladder mucosa was used as an inductor of osteogenesis. Using this model it is possible to compare the effects of bisphosphonates on preexisting mineral on ortothopic bones as well as on the early stages of mineral deposition in the newly formed bone induced in heterotopic sites. HEBP and Cl2MBP doesn't inhibit heterotopic bone induction, but HEBP deeply inhibits the mineralization process; the small amount of deposited mineral does not contain crystalline fraction.
Wojtowicz
N
N
Zakładu Transplantologii, Instytut Biostruktury, Akademia Medyczna w Warszawie.
Kamiński
A
A
Sotowski
R
R
Dziedzic-Gocławska
N
N
Stachowicz
W
W
D000818:Animals; D016025:Bone Transplantation; D002113:Calcification, Physiologic / Q000187:drug effects*; D004002:Clodronic Acid / Q000494:pharmacology*; D004195:Disease Models, Animal; D012968:Etidronic Acid / Q000494:pharmacology*; D006168:Guinea Pigs; D009999:Ossification, Heterotopic / Q000517:prevention & control; D010012:Osteogenesis / Q000187:drug effects; D016042:Transplantation, Heterotopic; D001743:Urinary Bladder
D004002:Clodronic Acid; D012968:Etidronic Acid
Wpływ bisfosfonianów (HEBP, CL2MBP) na proces biologicznej mineralizacji dojrzałej kości oraz tkanki kostnej powstajacej de novo w wyniku doświadczalnej indukcji osteogenezy u świnek morskich.