title: [Molecular changes in adenocarcinoma of the small intestine associated with Peutz-Jeghers syndrome].
abstract: The presence of molecular alterations in the c-K-ras and p53 genes in a small bowel adenocarcinoma arising in a case of Peutz-Jeghers syndrome is reported. The absence of mutations at codon 12 and 13 of the c-K-ras gene in the hamartoma and carcinoma indicates that this oncogene does not contribute to its development. On the other hand, p53 protein overexpression was detected in a small proportion (5-10%) of adenocarcinoma cells. Our findings suggest that p53 inactivation occur in late stages of tumour progression.
authors.affiliation: Servicio de Cirugía General, Consorci Sanitari de Mataró.
authors.forename: L
authors.initials: L
authors.lastname: Hidalgo
authors.forename: A
authors.initials: A
authors.lastname: Villanueva
authors.forename: T
authors.initials: T
authors.lastname: Soler
authors.forename: X
authors.initials: X
authors.lastname: Matías Guiu
authors.forename: G
authors.initials: G
authors.lastname: Capellá
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D007580:Jejunal Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D010580:Peutz-Jeghers Syndrome / Q000150:complications* / Q000473:pathology; D016133:Polymerase Chain Reaction
chemical_list: D003062:Codon
vernacular_title: Alteraciones moleculares en adenocarcinoma de intestino delgado asociado a síndrome de Peutz-Jeghers.