title: Persistence of cyclosporine after withdrawal of the drug in a patient with chronic liver transplant rejection. Role of the monoethylglycinexylidine test.
abstract: Patients with chronic rejection of liver allografts may show persistently high cyclosporine levels. This phenomenon may be due to a down-regulation of the P450 cytochrome system. The monoethylglycinexylidine test was useful in confirming this hypothesis.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Jindal
authors.forename: M D
authors.initials: MD
authors.lastname: Pescovitz
authors.forename: O W
authors.initials: OW
authors.lastname: Cummings
authors.forename: B
authors.initials: B
authors.lastname: Book
authors.forename: L
authors.initials: L
authors.lastname: Lumeng
authors.forename: M L
authors.initials: ML
authors.lastname: Milgrom
authors.forename: S B
authors.initials: SB
authors.lastname: Leapman
authors.forename: R S
authors.initials: RS
authors.lastname: Filo
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics*; D016031:Liver Transplantation
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System