Identification of a major co-receptor for primary isolates of HIV-1.
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
Deng
H
H
Skirball Institute for BioMolecular Medicine, New York University Medical Center, 10016, USA.
Liu
R
R
Ellmeier
W
W
Choe
S
S
Unutmaz
D
D
Burkhart
M
M
Di Marzio
P
P
Marmon
S
S
Sutton
R E
RE
Hill
C M
CM
Davis
C B
CB
Peiper
S C
SC
Schall
T J
TJ
Littman
D R
DR
Landau
N R
NR
D016475:3T3 Cells; D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism*; D002460:Cell Line; D018925:Chemokines / Q000378:metabolism / Q000502:physiology; D004247:DNA; D015686:Gene Products, env / Q000378:metabolism; D015497:HIV-1 / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000821:virology*; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism*; D015728:Receptors, HIV / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014779:Virus Replication
D015704:CD4 Antigens; D018925:Chemokines; D015686:Gene Products, env; D008565:Membrane Proteins; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D018121:Receptors, Cytokine; D015728:Receptors, HIV; D011994:Recombinant Proteins; D004247:DNA