title: [Gene frequency and haplotypes of the HLA system in the Panamanian population].
abstract: The authors determined the frequency of genes and haplotypes of the HLA system in 965 panamanian men and women not related to each other, between 6 and 65 years of age. The HLA-A locus genes with the highest frequency (f) were A2, with f 0.1763; A24, f 0.1584; A30, f 0.1340; A23, f 0.1069; A3, f 0.0774. The other 20 genes each had less than 0.07. The genes with the highest frequency for locus HLA-B were B35, f 0.1946; B44, f 0.0904; B7, f 0.0774; B60 and B61, f 0.0582. For locus HLA-C, the most frequent genes were Cw3 with f 0.1549 and Cw4, f 0.1444. For locus HLA-DR, the most frequent genes were DR2 with f 0.1283; DR3, f 0.0620; DR7, f 0.0409. The most frequent haplotypes in the panamanian population were A2-B35 with f 0.0382; A3-B35, f 0.0191; A24-35, f 0.0287; A24-B61, f 0.0239; A29-B44, f 0.0287; A30-B42, f 0.0239; A23-B44, f 0.0191; A1-B8, f 0.0143. The authors conclude that the panamanian population exhibits a high degree of polymorphism for loci HLA-A, B and C, while for locu HLA-DR the frequency is the median when compared with that in caucasian, negro and oriental groups; and that, according to locus, predominant genes originating from these groups and found, corroborating the multiracial origen of the panamanian population.
authors.affiliation: De los servicios de Inmunología Especializada e Histocompatibilidad, CHMAAM, de la Caja de Seguro Social.
authors.forename: A A
authors.initials: AA
authors.lastname: Vernaza-Kwiers
authors.forename: I J
authors.initials: IJ
authors.lastname: de Gómez
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Isaacs
authors.forename: C J
authors.initials: CJ
authors.lastname: Cuero
authors.forename: E
authors.initials: E
authors.lastname: Pérez Guardia
authors.forename: M
authors.initials: M
authors.lastname: Moreno Saavedra
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010176:Panama; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens
vernacular_title: Frecuencia de genes y haplotipos del sistema HLA en la poblacion Panameña.