[The effect of a low molecular weight synthetic humic substance on selected reproductive parameters of male rats].
Influences of the low molecular humic substance HS 1500 on parameters of organs (testis weight, epididymis weight), FSH-, and LH-levels in plasma as well as on the spermatogenesis of male rats were studied. After a daily oral application of 1000 mg/kg b.w. and 2000 mg/kg b.w., respectively over a period of 60 days (40th to 100th day of life) only 2 animals of the high dose group were observed with bilateral testicular atrophy. Despite of the two animals with testicular atrophy no significant differences between treated and control rats were observed with respect to testis morphology and spermatogenesis. There is no evidence whether the differences between the hormone levels and the testicular atrophy revealed is regarded to a HS 1500-effect or not. But otherwise a direct influence of HS 1500 can be ruled out with high certainty. Possibly because of the thin covering layer on the gastrointestinal mucous membrane formed by HS 1500, the absorption of nutritive substances is inhibited. Therefore the growth of sensitive organs like testis and epididymis, in the development period, can be decreased. Nevertheless, even after long time application the spermatogenesis is not influenced.
Faqi
A S
AS
Institut für Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinischen Fakultät, Universität Leipzig.
Lange
N
N
Kühnert
M
M
Haase
A
A
Höke
H
H
Seubert
B
B
D000284:Administration, Oral; D000818:Animals; D004822:Epididymis / Q000187:drug effects* / Q000254:growth & development; D005640:Follicle Stimulating Hormone / Q000097:blood; D062385:Hydroxybenzoates / Q000008:administration & dosage / Q000633:toxicity*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000254:growth & development
C099097:HS 1500; D062385:Hydroxybenzoates; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Untersuchungen zum Einfluss eines niedermolekularen synthetischen Huminstoffes auf ausgewählte Reproduktionsparameter männlicher Ratten.