title: The use of cyanoacrylate tissue adhesive in high-risk intestinal anastomoses.
abstract: The success of every intestinal surgical procedure primarily depends on correct technical execution of the intestinal sutures. Despite the continuing improvements in intestinal synthesis techniques and the introduction of mechanical staplers, the risk of anastomotic dehiscence remains a major concern. For high-risk anastomoses, defined as those performed under critical conditions, n-butyl-2-cyanoacrylate tissue adhesive allows for quick sealing of the two stumps and supports the physiological wound-healing process. Furthermore, no experimental or clinical studies have shown that this glue has any carcinogenic or mutagenic properties. Thus, we believe that n-butyl-2-cyanoacrylate will be extremely useful for intestinal anastomoses with a high risk of dehiscence.
authors.affiliation: Department of Surgery, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: G D
authors.initials: GD
authors.lastname: Tebala
authors.forename: F
authors.initials: F
authors.lastname: Ceriati
authors.forename: E
authors.initials: E
authors.lastname: Ceriati
authors.forename: A
authors.initials: A
authors.lastname: Vecchioli
authors.forename: S
authors.initials: S
authors.lastname: Nori
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000494:pharmacology; D007422:Intestines / Q000473:pathology / Q000601:surgery*; D013528:Surgical Staplers; D013529:Surgical Wound Dehiscence / Q000473:pathology; D013536:Suture Techniques; D013552:Swine; D014014:Tissue Adhesives; D014945:Wound Healing / Q000187:drug effects
chemical_list: D014014:Tissue Adhesives; D004659:Enbucrilate