Prevention of cyclosporine-induced nephrotoxicity by prazosin hydrochloride, an alpha-1-adrenoreceptor blocker.
Ishikawa
A
A
Department of Urology, Hamamatsu University School of Medicine, Japan.
Suzuki
K
K
Fujita
K
K
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000633:toxicity*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D007672:Kidney Cortex / Q000098:blood supply; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D011188:Potassium / Q000097:blood; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; D011188:Potassium; D011224:Prazosin