title: Adenovirus and Epstein-Barr virus in lung disease.
abstract: The adenovirus and the Epstein-Barr virus are double-stranded DNA viruses capable of infecting the human respiratory tract and producing a wide spectrum of pulmonary disorders. We review the viral factors and viral-host interactions that may be involved in the pathogenesis of pulmonary disorders associated with adenoviral and Epstein-Barr virus infections, focusing on the possible role of acute, persistent, and latent infections. Adenovirus and Epstein-Barr virus have evolved a remarkable array of strategies to survive within the infected host, and an improved understanding of these strategies is essential to developing innovative therapies to effectively manipulate viral-host interactions.
authors.affiliation: University of British Columbia Pulmonary Research Laboratory, St Paul's Hospital, Vancouver.
authors.forename: J C
authors.initials: JC
authors.lastname: Hogg
authors.forename: R G
authors.initials: RG
authors.lastname: Hegele
mesh_terms: D000256:Adenoviridae / Q000472:pathogenicity* / Q000648:ultrastructure; D002277:Carcinoma / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity*; D006689:Hodgkin Disease / Q000821:virology; D006790:Host-Parasite Interactions; D006801:Humans; D007244:Infectious Mononucleosis / Q000821:virology; D008171:Lung Diseases / Q000473:pathology / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000821:virology; D009303:Nasopharyngeal Neoplasms / Q000821:virology; D018235:Smooth Muscle Tumor / Q000821:virology; D017735:Virus Latency; D014779:Virus Replication