YM-47522, a novel antifungal antibiotic produced by Bacillus sp. II. Structure and relative stereochemistry.
YM-47522 (1) was isolated from the fermentation broth of Bacillus sp. YL-03709B as an antifungal antibiotic. The structure of 1 was elucidated by spectroscopic analyses. YM-47522 (1) consisted of C13 carboxylic acid amide and cinnamate moieties. The relative stereochemistry was also proposed on the basis of chemical transformation into a 1,3-diol acetonide and its NMR data.
Sugawara
T
T
Drug Serendipity Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
Shibazaki
M
M
Nakahara
H
H
Suzuki
K
K
D000935:Antifungal Agents / Q000737:chemistry*; D001407:Bacillus / Q000378:metabolism*; D002934:Cinnamates / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000935:Antifungal Agents; D002934:Cinnamates; D005231:Fatty Acids, Unsaturated; C099663:YM 47522