Expression of TGF-beta type I and type II receptors in rat eyes.
Transforming growth factor beta (TGF-beta) transduces signals through mediation of type I and type II serine/threonine kinase receptors. The expression of TGF-beta type I (T beta R-I) and II (T beta R-II) receptors in rat eyes was investigated immunohistochemically. T beta R-I and T beta R-II immunoreactivity was detected in corneal and conjunctival epithelial cells, corneal endothelial cells, ciliary epithelial cells, lens epithelial cells, retinal pigment epithelial cells, and choroidal vessels. This co-expression of T beta R-I and T beta R-II indicates that the above cells respond to TGF-beta and, because TGF-beta is reported to be produced in ocular tissues, that it may have important autocrine and/or paracrine roles in the growth and metabolism of ocular tissues in situ.
Obata
H
H
Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Japan.
Kaburaki
T
T
Kato
M
M
Yamashita
H
H
D030201:Activin Receptors, Type I; D000818:Animals; D000869:Anterior Eye Segment / Q000737:chemistry / Q000378:metabolism; D002829:Choroid / Q000098:blood supply / Q000737:chemistry / Q000378:metabolism; D002924:Ciliary Body / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism; D005123:Eye / Q000737:chemistry / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D007908:Lens, Crystalline / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D008297:Male; D010857:Pigment Epithelium of Eye / Q000737:chemistry / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D011917:Rats, Inbred Lew; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis / Q000096:biosynthesis*; D014018:Tissue Distribution; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; C000625843:Tgfbr1 protein, rat