Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione.
Mitchell
G A
GA
Service de Génétique Médicale Hôpital Ste. Justine, Quebec, Canada.
D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D000818:Animals; D003512:Cyclohexanones / Q000627:therapeutic use / Q000633:toxicity*; D004791:Enzyme Inhibitors / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D007928:Lethal Dose 50; D008661:Metabolism, Inborn Errors / Q000188:drug therapy* / Q000209:etiology; D009579:Nitrobenzoates / Q000627:therapeutic use / Q000633:toxicity*; D010666:Phenylpropionates / Q000652:urine; D010667:Phenylpyruvic Acids / Q000652:urine; D051381:Rats; D014443:Tyrosine / Q000097:blood*
D003512:Cyclohexanones; D004791:Enzyme Inhibitors; D009579:Nitrobenzoates; D010666:Phenylpropionates; D010667:Phenylpyruvic Acids; C010590:4-hydroxyphenylpyruvic acid; C001418:4-hydroxyphenyllactic acid; D014443:Tyrosine; D015111:4-Hydroxyphenylpyruvate Dioxygenase; C077073:nitisinone