title: What is the role of absorption atelectasis in the genesis of perioperative pulmonary collapse?
abstract: During anaesthesia the combination of breathing at low lung volume, the administration of nitrous oxide and high inspired oxygen concentrations produces conditions that favour absorption atelectasis. Measures such as adding nitrogen to the inspired mixture and avoiding high inspired oxygen concentrations would reduce the amount of perioperative atelectasis if gas absorption was important in the genesis of perioperative pulmonary collapse. Experimental results demonstrate that these measures do not protect against atelectasis. This indicates that absorption atelectasis does not play a significant role in the genesis of perioperative pulmonary collapse. Compression atelectasis may be the underlying mechanism.
authors.affiliation: Dunedin Public Hospital, New Zealand.
authors.forename: C J
authors.initials: CJ
authors.lastname: Joyce
authors.forename: A B
authors.initials: AB
authors.lastname: Baker
mesh_terms: D000042:Absorption; D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D007431:Intraoperative Complications / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D009584:Nitrogen / Q000008:administration & dosage / Q000493:pharmacokinetics; D009609:Nitrous Oxide / Q000008:administration & dosage / Q000493:pharmacokinetics; D010100:Oxygen / Q000008:administration & dosage / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D011183:Postoperative Complications / Q000378:metabolism; D001261:Pulmonary Atelectasis / Q000209:etiology / Q000378:metabolism*
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide; D009584:Nitrogen; D010100:Oxygen