[Arterial hypertension in the elderly. Is there still room for diuretics?].
Hypertension (HTA), whether systolic and diastolic or as isolated systolic hypertension, has been firmly established as a major risk factor of morbidity and cardiovascular mortality in elderly patients. Despite recent controversies that have appeared in the literature on the metabolic disturbances caused by diuretics, especially hypokalemia, and the absence of a significant advantage on coronary mortality, these drugs should nevertheless be considered as extremely important in the treatment of HTA. Prescribed at small doses, their long-term effects are by far the best documented of all antihypertensive drugs. Their mechanisms as well as their main side effects are described below. Finally, the authors give some simple guidelines on their use, more specifically in elderly patients.
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Hôpital de la Providence, Neuchâtel.
Gauchat
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Guelpa
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D000368:Aged; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced
D001786:Blood Glucose; D004232:Diuretics; D008055:Lipids; D012964:Sodium; D011188:Potassium
Hypertension artérielle du sujet âgé. Quelle place reste-t-il pour les diurétiques?