title: Serum nifedipine concentrations and response of patients with pulmonary hypertension.
abstract: In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.
authors.affiliation: Department of Pharmacy Practice, University of Illinois, Chicago 60612 USA.
authors.forename: B G
authors.initials: BG
authors.lastname: Phillips
authors.forename: J L
authors.initials: JL
authors.lastname: Bauman
authors.forename: M D
authors.initials: MD
authors.lastname: Schoen
authors.forename: T J
authors.initials: TJ
authors.lastname: Hoon
authors.forename: B J
authors.initials: BJ
authors.lastname: Schrader
authors.forename: S
authors.initials: S
authors.lastname: Rich
mesh_terms: D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage* / Q000097:blood*; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D014665:Vasodilator Agents; D009543:Nifedipine