[Clearance, reabsorption and excretion of free and bound L-carnitine in children].
Acylcarnitines are by-products of fatty acid, pyruvate and some xenobiotics metabolism excreted in urine. We compare the renal handling of free and acylcarnitine in a group of 15 healthy children in relation to sodium and urea excretion and to sodium fractional tubular reabsorption (FTR%) and fractional excretion (FE%). Urea and sodium were determined by routine laboratory method; free and acylcarnitines by enzymatic one. FTR% and FE% were determined as a % of filtration load. Linear regression was used for calculation of correlation coefficient "r" from paired data. Low correlation (r = 0.25; p = 0.42) between urea and free carnitine excretion was observed; for excretion of acylcarnitine and urea correlation was much higher (r = 0.61; p < 0.03). Excretion of free correlation was negatively correlated with sodium FTR (r = -0.86; p < 0.001) and there was no correlation at all for acylcarnitine excretion and sodium FTR. It can be assumed:-neither excretion nor reabsorption of acylcarnitines are Na-dependent;-renal handling of free and total carnitines proceeds on different mechanisms.
Karpowicz
B
B
Kliniki Nefrologii Dzieciecej Instututu Pediatrii, Gdańsku.
Kuchta
G
G
Marczak
E
E
Rutkowski
B
B
Lysiak-Szydlowska
W
W
D000293:Adolescent; D002331:Carnitine / Q000378:metabolism*; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012044:Regression Analysis; D012964:Sodium / Q000652:urine; D014508:Urea / Q000652:urine
D014508:Urea; D012964:Sodium; D003404:Creatinine; D002331:Carnitine
Klirens, reabsorpcja i wydalanie wolnej i zwiazanej L-karnityny u dzieci.