Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists.
Boyfield
I
I
SmithKline Beecham Pharmaceuticals, Harlow, Essex, U.K.
Brown
T H
TH
Coldwell
M C
MC
Cooper
D G
DG
Hadley
M S
MS
Hagan
J J
JJ
Healy
M A
MA
Johns
A
A
King
R J
RJ
Middlemiss
D N
DN
Nash
D J
DJ
Riley
G J
GJ
Scott
E E
EE
Smith
S A
SA
Stemp
G
G
D018492:Dopamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D015195:Drug Design; D004952:Esters / Q000737:chemistry; D006801:Humans; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D011869:Radioligand Assay; D050638:Receptors, Dopamine D4
C493599:DRD4 protein, human; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004952:Esters; D009281:Naphthalenes; D050638:Receptors, Dopamine D4; C030037:2-naphthoic acid