Lesions of primary and secondary syphilis contain activated cytolytic T cells.
This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated.
van Voorhis
W C
WC
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
Barrett
L K
LK
Nasio
J M
JM
Plummer
F A
FA
Lukehart
S A
SA
D001483:Base Sequence; D053804:Granzymes; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D012697:Serine Endopeptidases / Q000235:genetics; D013587:Syphilis / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014210:Treponema pallidum / Q000276:immunology
D012333:RNA, Messenger; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases