[Ribonuclease stimulation of nonspecific factors of protection in experimental animals].
It was shown that a single intraperitoneal administration of Bacillus intermedius RNAse to rats stimulated the activity of lysozyme and blood serum complement. A single intraperitoneal administration of pancreatic RNAse, Bacillus intermedius RNAse and its derivative selectively inactivated by the histidine active centre stimulated the metabolic activation of neutrophils as was shown by their ability to reduce tetrazolium nitroblue to diphormazone. The efficiency of the neutrophil stimulation by the RNAses was comparable with that of the microbial vaccine and did not depend on the catalytic activity of the RNAses.
Kurinenko
B M
BM
Nekhoroshkova
Z M
ZM
Bulgakova
R Sh
RSh
D000818:Animals; D001407:Bacillus / Q000201:enzymology; D003165:Complement System Proteins / Q000819:agonists*; D004734:Energy Metabolism / Q000187:drug effects; D007274:Injections, Intraperitoneal; D009113:Muramidase / Q000819:agonists*; D009504:Neutrophils / Q000187:drug effects*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010084:Oxidation-Reduction; D010179:Pancreas / Q000201:enzymology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D012260:Ribonucleases / Q000494:pharmacology*; D013268:Stimulation, Chemical
D009580:Nitroblue Tetrazolium; D003165:Complement System Proteins; D012260:Ribonucleases; D009113:Muramidase
Stimuliatsiia ribonukleazami nespetsificheskikh faktorov zashchity v organizme éksperimental'nykh zhivotnykh.