Blood pressure-lowering effect of adding grapefruit juice to nifedipine and terazosin in a patient with severe renovascular hypertension.
Grapefruit juice had been fortuitously noted to elevate the concentration of felodipine in a pharmacological study of the effect of ethanol on felodipine. This effect was later confirmed not only for felodipine but also for three other dihydropyridine calcium channel blockers. I herein present what I believe to be the first case report describing a marked blood pressure-lowering effect of grapefruit juice in a person receiving an antihypertensive regimen of a dihydropyridine calcium channel blocker (nifedipine) and terazosin.
Pisarik
P
P
CIGNA Healthcare, Mesa, Ariz, USA.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D001628:Beverages; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002957:Citrus; D018565:Food-Drug Interactions; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; C041226:Terazosin; D009543:Nifedipine; D011224:Prazosin