Immunodeficiency in protein kinase cbeta-deficient mice.
Cross-linking of the antigen receptor on lymphocytes by antigens or antibodies to the receptor results in activation of enzymes of the protein kinase C (PKC) family. Mice homozygous for a targeted disruption of the gene encoding the PKC-betaI and PKC-betaII isoforms develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B cells, which is similar to X-linked immunodeficiency in mice. Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction.
Leitges
M
M
Max-Delbrück-Laboratorium in der Max-Planck-Gesellschaft, Carl-von-Linné-Weg 10, D-50829 Köln, Germany.
Schmedt
C
C
Guinamard
R
R
Davoust
J
J
Schaal
S
S
Stabel
S
S
Tarakhovsky
A
A
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D018390:Gene Targeting; D008040:Genetic Linkage; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007136:Immunoglobulins / Q000097:blood*; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology / Q000276:immunology*; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D051379:Mice; D011493:Protein Kinase C / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D064546:Protein Kinase C beta; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology; D014960:X Chromosome
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625951:Btk protein, mouse; D011493:Protein Kinase C; D064546:Protein Kinase C beta