Radiographic findings of intractable gastric ulcers with H2-receptor antagonists.
BACKGROUND
To clarify the radiographic characteristics of intractable gastric ulcers with H2-receptor antagonists.


METHODS
The radiographic findings at the time of starting treatment were compared between 42 patients with gastric ulcers that did not heal within eight weeks of starting treatment with H2-receptor antagonists (the intractable group) and 58 patients whose ulcers healed within the eight-week period (the tractable group).


RESULTS
The following radiographic findings in the intractable group were observed at a significantly higher incidence than those in the tractable group and included: an ulcer located on the angle, linear ulcers, a greater depth, an uneven mound surrounding an ulcer, prominent folds' convergence, an overhanging gastric mucosa, an irregular ulcer base, a shortening of the lesser curvature and a U-shaped deformity of the angle. A multiple logistic regression analysis showed that the following three factors had a significant and independent delaying effect on healing: a U-shaped deformity of the angle, an uneven mound surrounding an ulcer and prominent folds' convergence. The relative risk of these factors were 12.7, 14.4 and 12.5, respectively.


CONCLUSIONS
Intractable gastric ulcer with H2-receptor antagonists can be predicted based on the characteristic radiographic findings at the start of treatment.
Okada
M
M
First Department of Internal Medicine, School of Medicine, Fukuoka University 45-1, 7-chome Nanakuma, Jonan-ku, Fukuoka, 814-01, Japan.
Shirotani
T
T
Sakurai
T
T
Yao
T
T
Seo
M
M
Okada
Y
Y
Sakamoto
K
K
Tanaka
K
K
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001466:Barium Sulfate; D003287:Contrast Media; D005260:Female; D005753:Gastric Mucosa / Q000000981:diagnostic imaging; D005773:Gastroscopy; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000000981:diagnostic imaging* / Q000188:drug therapy; D017211:Treatment Failure; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D003287:Contrast Media; D006635:Histamine H2 Antagonists; D001466:Barium Sulfate