Sensitivity of Escherichia coli O157:H7 strain 932 to selected anticoccidial drugs in broiler chicks.
The ability of selected anticoccidial drugs to inhibit the colonization of day-old male broiler chicks (Cornish Rocks) by Escherichia coli O157:H7, strain 932 was examined. Chicks were challenged with 1.8 x 10(9) E. coli O157:H7 on Day 1, and fed diets supplemented with three selected anticoccidial drugs; monensin, nicarbazin, or robenidine. The cecal and colon fecal contents of the chicks were removed on Day 7, 14, and 21 postinoculation and examined for the concentration of E. coli O157: H7 per gram of contents. Monensin effectively reduced cecal and colon colonization of the chicks by E. coli O157:H7. By Day 7, there were significant reductions in the bacterial population of the cecal contents of chicks receiving the monensin-medicated feed, and by Day 21 no E. coli O157:H7 was recovered from the cecal and colon contents. The bacterial counts in the colon contents of the nicarbazin- and robenidine-medicated and unmedicated chicks were significantly higher than the monensin-treated chicks. Bacterial populations in the colon contents were high only when there were high bacterial concentrations in the cecal contents.
Stanley
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VG
Cooperative Agricultural Research Center, Prairie View A&M University, Texas 77446, USA.
Woldesenbet
S
S
Gray
C
C
Hinton
A
A
D000818:Animals; D002432:Cecum / Q000382:microbiology*; D002645:Chickens / Q000382:microbiology*; D003049:Coccidiostats / Q000008:administration & dosage / Q000494:pharmacology*; D003106:Colon / Q000382:microbiology*; D015169:Colony Count, Microbial / Q000662:veterinary; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D005527:Food, Fortified; D008297:Male; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D008985:Monensin / Q000008:administration & dosage / Q000494:pharmacology; D009528:Nicarbazin / Q000008:administration & dosage / Q000494:pharmacology; D012370:Robenidine / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D003049:Coccidiostats; D009528:Nicarbazin; D012370:Robenidine; D008985:Monensin