Factors influencing the development of glucose intolerance in Cushing syndrome.
BACKGROUND
Although the frequency of glucose intolerance in endogenous Cushing syndrome has been repeatedly evaluated, no attempt has been made so far at analyzing simple clinical factors in order to quantify their influence on the development of glucose intolerance.


METHODS
The influence of 6 factors on the development of glucose intolerance (family history of diabetes, age and body mass index of patients, duration of hypercortisolism, its pathogenetic form, and the extent of its clinical manifestation) was evaluated by means of multiple regression in 74 patients with Cushing syndrome.


RESULTS
The disappearance of a normal glucose tolerance in Cushing syndrome was a function of the time of duration of hypercortisolism.  The emergence of diabetes mellitus, but not of impaired glucose tolerance, was supported by ageing. Surprisingly, the family history failed to have any predictive value.


CONCLUSIONS
The results suggest that diabetes mellitus in endogenous Cushing syndrome is a disorder genetically different from primary diabetes mellitus.
Kreze
A
A
Institute of Clinical Endocrinology, Lubochna, Slovak Republic.
Mikulecky
M
M
Moravcik
M
M
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012307:Risk Factors
D001786:Blood Glucose; D006854:Hydrocortisone