[Functional magnetic resonance imaging (MRI) of hepatic ischemia in the rabbit. Contribution of a particulated contrast agent (AMI-25)].
A functional approach of the rabbit portal ischemia was performed on five New Zealand rabbits using magnetic-resonance (MR) imaging and an MR-specific contrast agent for the liver. The hepatic vascularization and the functionality of the phagocytosis cells were both studied with a single low dose of a unique contrast agent-superparamagnetic iron oxide particles (SPIOs). After a rapid i.v. injection of SPIOs, functional vessels and normally perfused liver parenchyma appeared with positive signal enhancement, whereas the ischemic area remained dark (cold spot). After the intravascular time period, the well-known negative enhancement induced by these particles on normal parenchyma was observed, with the difference of the ischemic liver, and could be related to the uptake of SPIOs by functional Kupffer cells.
Canet
E
E
Hôpital cardiologique, Lyon, France.
Roger
T
T
Chambon
C
C
Delabre
C
C
Baldy
C
C
Revel
D
D
D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D007501:Iron; D007511:Ischemia / Q000175:diagnosis / Q000662:veterinary*; D008099:Liver / Q000098:blood supply*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D058185:Magnetite Nanoparticles; D010087:Oxides; D011817:Rabbits; D013535:Suspensions
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D013535:Suspensions; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide
Imagerie par résonance magnétique (IRM) fonctionnelle de l'ischémie hépatique chez le lapin. Contribution d'un agent de contraste particulaire (AMI-25).