Temporal variation in hepatic superoxide dismutase activity in mice.
Circadian variations in superoxide dismutase (SOD) activity were determined in liver homogenates of Balb-C mice that were synchronized under controlled environmental conditions with 12 h light:12 h dark. The activity of hepatic SOD exhibited a significant circadian rhythm, with a minimum at 01:00 h and a maximum at 10:00-13:00 h. It is concluded that fluctuations in hepatic SOD activity render mice more susceptible to the toxic effects of reactive oxygen radicals at particular times of the day.
Hodoğlugil
U
U
Department of Pharmacology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ongun
O
O
Güney
Z
Z
Altan
N
N
Zengil
H
H
D000704:Analysis of Variance; D000818:Animals; D002940:Circadian Rhythm; D003624:Darkness; D008027:Light; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017382:Reactive Oxygen Species / Q000633:toxicity; D013482:Superoxide Dismutase / Q000378:metabolism*
D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase