title: [Experimental osteoporosis caused by estrogen deficiency in rats. Role of a lactose, L-arginine and L-lysine combination in the prevention and therapy].
abstract: The role of a lactose, L-arginine and L-lysine association in the treatment of osteoporosis was evaluated in an in vivo model. Fifty Sprague Dawley female rats, 10 months age, were divided into 5 groups: 10 non-ovariectomized animals sacrificed at the beginning of the study (I group); 10 ovariectomized animals (OVX) without treatment and sacrificed at three months (II group); 10 OVX animals without treatment sacrificed at 6 months; 10 OVX animals treated starting from the I post-operative day with the association for three months (IV group, prevention) and 10 OVX animals treated like those of the IV group starting three months after surgery (V group, therapy). Animals were sacrificed in general anesthesia according to the scheduled times for radiologic, densitometric, histologic and mineralogic investigations. Preliminary results, which will need further researches, seem to show a progressive reduction of bone mass after ovariectomy in 10 months female rat and that the pharmacological association given as therapy (V group) may be able to lessen the reduction of bone mineral content.
authors.affiliation: Servizio di Chirurgia Sperimentale IOR Università degli Studi, Bologna.
authors.forename: M
authors.initials: M
authors.lastname: Fini
authors.forename: R
authors.initials: R
authors.lastname: Giardino
authors.forename: R
authors.initials: R
authors.lastname: Mongiorgi
authors.forename: G
authors.initials: G
authors.lastname: Cantelli Forti
authors.forename: S
authors.initials: S
authors.lastname: Gnudi
authors.forename: N
authors.initials: N
authors.lastname: Nicoli Aldini
authors.forename: C
authors.initials: C
authors.lastname: Valdrè
authors.forename: D
authors.initials: D
authors.lastname: Piotti
authors.forename: G
authors.initials: G
authors.lastname: Giavaresi
authors.forename: L
authors.initials: L
authors.lastname: Orienti
authors.forename: M
authors.initials: M
authors.lastname: Rocca
authors.forename: A
authors.initials: A
authors.lastname: Sapone
authors.forename: A
authors.initials: A
authors.lastname: Rossetti
mesh_terms: D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D007785:Lactose / Q000008:administration & dosage*; D008239:Lysine / Q000008:administration & dosage*; D010024:Osteoporosis / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D001120:Arginine; D007785:Lactose; D008239:Lysine
vernacular_title: Osteoporosi sperimentale da carenza estrogenica nel ratto. Ruolo dell'associazione lattosio, L-arginina, L-lisina nella prevenzione e terapia.