Tutorial in biostatistics. Designing studies for dose response.
'Dose response' refers to the regression of a response on a stimulus. We review a number of options for dose-response designs, and compare various designs which may be used in practice. We start with two group designs. Next, we introduce basic optimal approximate design theory for simple linear and quadratic regression illustrating different criteria of optimality and their effect on the allocation of the levels of the dose. Then we obtain the efficiencies of these optimal approximate designs and some simple designs which have intuitive appeal (symmetry, equal spacing of treatments, reduced numbers of observations at the highest and lowest doses).
Wong
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UCLA Department of Biostatistics 90024-1772, USA.
Lachenbruch
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D004305:Dose-Response Relationship, Drug; D016014:Linear Models; D012044:Regression Analysis; D012107:Research Design