title: A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
abstract: A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.
authors.affiliation: Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: K
authors.initials: K
authors.lastname: Savitsky
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
authors.forename: A
authors.initials: A
authors.lastname: Bar-Shira
authors.forename: S
authors.initials: S
authors.lastname: Gilad
authors.forename: D A
authors.initials: DA
authors.lastname: Tagle
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Uziel
authors.forename: S
authors.initials: S
authors.lastname: Sfez
authors.forename: J
authors.initials: J
authors.lastname: Nahmias
authors.forename: A
authors.initials: A
authors.lastname: Sartiel
authors.forename: R L
authors.initials: RL
authors.lastname: Eddy
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: F S
authors.initials: FS
authors.lastname: Collins
authors.forename: Y
authors.initials: Y
authors.lastname: Shiloh
authors.forename: G
authors.initials: G
authors.lastname: Rotman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics; D001483:Base Sequence; D002460:Cell Line; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D006224:Cricetinae; D018076:DNA, Complementary; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D011544:Pseudogenes; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D018911:Trinucleotide Repeats
chemical_list: D018076:DNA, Complementary; D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases