title: A simple auditory oddball task in young adult males at high risk for alcoholism.
abstract: The reduction in the amplitude of the auditory P300 in young adult males at high risk for alcoholism has not been as consistently replicated as has been the reduction in the visual P300 amplitude in the same group. The easier nature of the auditory task was thought to be responsible for the inconsistency. We examined the auditory P300 amplitude in a group that has not yet been studied, young adult sons of alcoholics (mean age = 24.9 years, n = 48), and compared them with age and sex-matched controls (mean age = 27.8 years, n = 23). We found the auditory P300 amplitude to be reduced in the high-risk group and this reduction to be the greatest over the posterior centroparietal and occipital areas when individual leads were examined. We further analyzed the data using current source density, a mathematical transformation that circumvents some of the errors inherent in measuring scalp-evoked potentials, and found reduced current source density in the high-risk group in the posterior central and parietal areas. Thus, we found that a simple auditory oddball task was effective in eliciting P300 differences in groups at high and low risk for alcoholism. The clinical significance of the P300 is discussed, as well as the relevance of task difficulty in eliciting auditory P300 differences in young males at high risk for alcoholism.
authors.affiliation: Department of Neurology, Columbia Presbyterian Medical Center, New York, New York, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ramachandran
authors.forename: B
authors.initials: B
authors.lastname: Porjesz
authors.forename: H
authors.initials: H
authors.lastname: Begleiter
authors.forename: A
authors.initials: A
authors.lastname: Litke
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D001143:Arousal / Q000235:genetics* / Q000502:physiology; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography / Q000295:instrumentation; D018913:Event-Related Potentials, P300 / Q000235:genetics* / Q000502:physiology; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000235:genetics / Q000502:physiology; D012307:Risk Factors; D012815:Signal Processing, Computer-Assisted