WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.
Mutations in the WAF1/CIP1 gene were not found in 36 ovarian carcinomas, including tumours with loss of heterozygosity at the WAF1/CIP1 locus and/or lacking p53 mutations. In addition, no association was demonstrable between a polymorphism in a conserved region of the WAF1/CIP1 gene and ovarian carcinoma.
Wan
M
M
Department of Pathology, Kenneth Norris Jr. Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
Cofer
K F
KF
Dubeau
L
L
D001483:Base Sequence; D002453:Cell Cycle / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers; D004791:Enzyme Inhibitors; D005091:Exons; D005260:Female; D017353:Gene Deletion; D016158:Genes, p53; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000503:physiopathology*
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D017931:DNA Primers; D004791:Enzyme Inhibitors