title: Apolipoproteins AI and B and plasma lipid values in well-treated diabetic patients from Romania.
abstract: This review is aiming to study the values of apolipoprotein AI and B and plasma lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride) in well-treated diabetic patients, and their possible relationship with hemoglobin A1, body mass index and insulin levels. The study groups were 26 insulin-dependent diabetic (IDDM) patients, 30 non-insulin-dependent diabetic (NIDDM) subjects and 20 non diabetic subjects (controls). Apolipoprotein AI concentrations were similar in the three groups, but apolipoprotein B values and apo B/apo AI ratio were significantly higher in IDDM as related to NIDDM patients (p < 0.001) and to non-diabetic subjects (p < 0.001). We were not able to find significant differences concerning plasma lipid values between the three groups. We found a weak correlation between apo B and hemoglobin AI in IDDM (r = 0.45; 0.02 < p < 0.05), but not in NIDDM patients. Body mass index was not related to the values of apolipoproteins AI and B. We found a positive but weak correlation between insulin levels and triglyceride (r = 0.42), and an inverse one with HDL cholesterol (r = 0.57; 0.02 < p < 0.05) in non-diabetic subjects only, while in NIDDM patients these associations were even less significant. Plasma insulin values strongly correlate to body mass index in both NIDDM (r = 0.64; p < 0.001) and in control subjects (r = 0.73; 0.001 < p < 0.001).
authors.affiliation: County Hospital, University of Medicine and Pharmacy, Timişoara, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Dabelea
authors.forename: V
authors.initials: V
authors.lastname: Serban
authors.forename: G
authors.initials: G
authors.lastname: Băcanu
authors.forename: G
authors.initials: G
authors.lastname: Deutsch
authors.forename: C
authors.initials: C
authors.lastname: Pataki
authors.forename: I
authors.initials: I
authors.lastname: Dan
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000628:therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012383:Romania
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids