Cancer-associated retinopathy with presumed vasculitis.
OBJECTIVE
To treat a 63-year-old woman who experienced fairly rapid vision loss in association with small-cell carcinoma of the lung.


METHODS
She underwent a full ophthalmologic examination, including fluorescein angiography and an immunologic study by Western blot analysis.


RESULTS
Fluorescein angiography demonstrated diffuse staining of the retinal vessels. She had 62-kd antiretinal antibody in her serum. Cancer-associated retinopathy was diagnosed.


CONCLUSIONS
The staining seen on the angiogram appears to indicate vasculitis, which would cause the characteristic attenuation of retinal vessels in this disease.
Suzuki
T
T
Department of Ophthalmology, Dokkyo University School of Medicine, Koshigaya Hospital, Saitama, Japan. vyc13061@niftyserve.or.jp
Obara
Y
Y
Sato
Y
Y
Saito
G
G
Ichiwata
T
T
Uchiyama
T
T
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis; D015153:Blotting, Western; D002135:Calcium-Binding Proteins / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005136:Eye Proteins; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D051603:Recoverin; D012164:Retinal Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014657:Vasculitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D011241:Prednisone