Lipid peroxidation, antioxidant defences and red-cell membrane changes in relation to coronary risk index and symptomatic coronary heart disease.
OBJECTIVE
To establish the normal lipoprotein profile in the population and identify the early warning signs of coronary heart disease (CHD).


METHODS
Random blood sampling of healthy adults and patients with symptomatic CHD including that complicated with acute myocardial infarction.


METHODS
Plasma lipids, lipoproteins, lipid peroxidation, antioxidant enzymes and scavengers, red-cell membrane lipids and glycoproteins were assayed.


CONCLUSIONS
The normal levels of plasma lipids and lipoproteins were established. Levels of plasma free fatty acids, fibrinogen, white blood cell counts, echinocytes, red-cell membrane lipids and protein-bound carbohydrate components are significantly higher in healthy subjects with coronary risk index above 4.5 than they are in normal individuals. Antioxidant defences appear to be the distinguishing factor, remaining higher in normal individuals and thus keeping lipid peroxidation under control. In symptomatic CHD, antioxidant defences are significantly lowered.
Shanmugasundaram
K R
KR
Department of Biochemistry, University of Madras, Taramani, India.
Srinivas
K
K
Sundaram
P
P
Sathyaraj
D
D
Muthu
R
R
Padma
P
P
Maheswari
R U
RU
Veeraraghavan
V
V
Sharada
V
V
Amudha
B
B
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D004910:Erythrocyte Membrane; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D016166:Free Radical Scavengers; D006801:Humans; D007194:India; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology; D010976:Platelet Count; D012016:Reference Values; D002787:Sterol Esterase / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016166:Free Radical Scavengers; D008074:Lipoproteins; D005340:Fibrinogen; C031695:acid cholesterol ester synthetase; D002787:Sterol Esterase