Hepatic bile acid synthesis and DNA synthetic rate after partial hepatectomy.
The relationship between hepatic DNA synthetic rate and activity of cholesterol 7 alpha-hydroxylase, the rate limiting enzyme for bile acid synthesis, was examined in regenerating liver after partial hepatectomy or sham operation in rats. Hepatic cholesterol 7 alpha-hydroxylase activity was significantly (P < 0.001) suppressed on days 1 and 2, returned to the control level on day 3, and was significantly raised on day 7 after hepatectomy. The rate of DNA synthesis was significantly (P < 0.001) activated during the first 3 days after hepatectomy and returned to the control level on day 7. Enzyme activities regulating hepatic bile acid synthesis and DNA synthesis change inversely during liver regeneration after hepatectomy.
Chijiiwa
K
K
Department of Surgery 1, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Kozaki
N
N
Naito
T
T
Okamoto
S
S
Kuroki
S
S
Yamashita
H
H
Tanaka
M
M
D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis*; D006498:Hepatectomy / Q000379:methods*; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001647:Bile Acids and Salts; D004247:DNA