title: [The long-term treatment of patients with benign prostatic hyperplasia using Proscar].
abstract: The drug proskar (finasterid) has been developed and synthetized in "Merck Sharp & Dohme" research laboratories and tried initially in healthy male volunteers. Proskar is highly active as a blocker of 5-alpha-reductase blocking conversion of testosteron in dehydrotestosteron (DHT). The assessment of proskar effect on the prostate has been performed in 2000 patients throughout the world, including Russia. Follow-up studies (up to 5 years) demonstrate that proskar in the dose 5 mg/day produces a reduction in the levels of specific prostatic antigen, serum DHT and prostatic size, an increase in urination rate, life quality. In benign prostatic hyperplasia proskar realizes its effect in hormonal nature of the disease. The advantages are also safety and rare occurrence of side effects. The response became noticeable on the treatment month 6.
authors.forename: N A
authors.initials: NA
authors.lastname: Lopatkin
authors.forename: P J
authors.initials: PJ
authors.lastname: Roilans
authors.forename: E
authors.initials: E
authors.lastname: Stoner
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000368:Aged; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D018120:Finasteride / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D018120:Finasteride
vernacular_title: Dlitel'noe lechenie bol'nykh s dobrakachestvennoĭ giperplazieĭ predstatel'noĭ zhelezy proskarom.