title: Relationship of medical status, medications, and salivary flow rates in adults of different ages.
abstract: Multiple systemic disorders and medications have been reported to cause xerostomia or salivary gland hypofunction. The purpose of this study was to evaluate the relationship among systemic disorders, medications, and salivary flow rates. Sixty-three ambulatory dental patients aged 23 to 82 years were randomly selected. The nature, duration, and number of systemic disorders and medications were documented. Repeated measurements of unstimulated whole, chewing-stimulated whole, acid-stimulated parotid, and candy-stimulated parotid salivary flow rates were obtained. Data were analyzed with the Wilcoxon rank-sum test, nonparametric multivariate analysis of variance, and Fisher's exact test. For persons with systemic disorders who were taking medication, all salivary flow rates were significantly (p = 0.03 - 0.001) lower than the flow rates in healthy persons. Among persons with at least one systemic disorder who were taking medication, those who had been taking medication for longer than 2 years had significantly lower unstimulated whole saliva (p = 0.002), chewing-stimulated whole saliva (p = 0.0004), and candy-stimulated parotid saliva (p = 0.02) flow rates than those who had been taking medication for 1 to 2 years. The number of systemic disorders significantly (p = 0.02) and negatively affected the acid-stimulated parotid salivary rates. The prevalence of salivary hypofunction determined on the basis of unstimulated whole saliva and acid-stimulated parotid saliva was significantly higher (p = < 0.001, p = 0.007) in the those persons with systemic disorders and taking medications. The results suggest that salivary secretion is affected by the number of systemic disorders and duration of the potentially xerogenic medications.
authors.affiliation: Department of Dental Medicine and Public Health, School of Dentistry, University of Southern California, Los Angeles 90089, USA.
authors.forename: M
authors.initials: M
authors.lastname: Navazesh
authors.forename: V J
authors.initials: VJ
authors.lastname: Brightman
authors.forename: J M
authors.initials: JM
authors.lastname: Pogoda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002182:Candy; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D004194:Disease; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008409:Mastication; D008875:Middle Aged; D015999:Multivariate Analysis; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism; D012636:Secretory Rate; D013997:Time Factors; D014987:Xerostomia / Q000209:etiology
chemical_list: D002951:Citrates; D019343:Citric Acid