title: A fast method for in vivo lactate imaging.
abstract: A robust method for fast lactate imaging is presented using a combination of a lactate editing sequence and a one-shot imaging experiment. The lactate editing method is based on manipulation of the phase of the lactate CH3 signal via J-modulation. This is applied as a preparation experiment to the U-FLARE imaging sequence. Phantom experiments are presented in which the quality of water and lipid suppression is established. Edited lactate images with a spatial resolution of 3 microL and total measuring time of 15.8 min are shown. These were obtained from a hemispherical ischemia in the gerbil brain. The images are compared with diffusion-weighted water images.
authors.affiliation: Fachbereich Chemie, Universität Bremen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Reese
authors.forename: D G
authors.initials: DG
authors.lastname: Norris
authors.forename: D
authors.initials: D
authors.lastname: Leibfritz
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism; D005849:Gerbillinae; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007773:Lactates / Q000032:analysis* / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D007773:Lactates; D019344:Lactic Acid