Selection of high affinity RNA ligands to a synthetic peptide of human rhinovirus 14 coat protein.
We have used the in vitro evolution system (SELEX) to isolate high affinity RNAs which block the canyon region of Human Rhinovirus 14 (HRV 14). Since the genetic diversity of HRV has hampered the development of general anti-rhinovirus vaccines, high affinity RNAs may have good advantage for therapeutic application for the human cold.
De Beuckelaer
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Abteilung Prof. V. A. Erdmann, Institut für Biochemie, Freie UniversitäBBerlin, Germany.
Fürste
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JP
D001665:Binding Sites; D002213:Capsid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D036022:Capsid Proteins; D003139:Common Cold / Q000628:therapy; D019143:Evolution, Molecular; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D010455:Peptides / Q000138:chemical synthesis / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D012229:Rhinovirus / Q000235:genetics*
D036022:Capsid Proteins; D008024:Ligands; D010455:Peptides; D012313:RNA