[Accidental administration of 50 mg racemic adrenaline to a 2-year-old boy].
A two-year-old boy received by mistake 50 mg racemic adrenaline intravenously, corresponding to 1.8 mg kg-1 of L-adrenaline. Blood pressure increased to 160/105 mm Hg, heart rate to 160 beats min-1 and pulmonary oedema developed over the next two hours. He was treated with nitroprusside, nitroglycerine and digitoxin, and was intubated and ventilated. After three hours a hypotensive phase occurred, probably due to down-regulation of the beta- and alpha-adrenoceptors. This recessitated infusions of very high concentrations of catecholamines for 72 hours. Renal failure recessitated renal transplantation, after which the child made an uneventful recovery.
Dybvik
T
T
Anestesiavdelingen Klinikk for akuttmedisin Ullevål sykehus.
Halvorsen
P
P
Steen
P A
PA
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000601:surgery; D002675:Child, Preschool; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008508:Medication Errors; D064705:Racepinephrine; D013566:Sympathomimetics / Q000008:administration & dosage / Q000009:adverse effects*
D013566:Sympathomimetics; D064705:Racepinephrine; D004837:Epinephrine
Feiladministrering av 50 mg racemisk adrenalin hos en to år gammel gutt.