title: Serum hyaluronan concentrations predict survival in patients with chronic renal failure on maintenance haemodialysis.
abstract: BACKGROUND
  Malnutrition and wasting are common in chronic renal failure and are adverse prognostic features. The underlying mechanisms are complex and not fully understood. Hyaluronan is present in increased concentrations in chronic renal failure and may be associated with adverse features of chronic renal failure.
  
  
  METHODS
  We have investigated the relationship of this abnormality to long-term survival. Outcome of 81 patients of median of 5.6 years (3.9-6.8) after measurement of hyaluronan was determined.
  
  
  RESULTS
  Survival analysis by the Cox regression model showed that increased concentrations of hyaluronan (P < 0.0001). There was also a weak but significant negative correlation between hyaluronan concentrations and serum albumin concentrations (rs = - 0.27, P = 0.02).
  
  
  CONCLUSIONS
  We conclude that serum hyaluronan is a strong independent predictor of long-term survival in CRF may reflect abnormal connective tissue metabolism in this condition.
authors.affiliation: Renal Unit, Leeds General Infirmary, UK.
authors.forename: G
authors.initials: G
authors.lastname: Woodrow
authors.forename: J H
authors.initials: JH
authors.lastname: Turney
authors.forename: A M
authors.initials: AM
authors.lastname: Davison
authors.forename: E H
authors.initials: EH
authors.lastname: Cooper
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000378:metabolism; D015996:Survival Rate
chemical_list: D012709:Serum Albumin; D006820:Hyaluronic Acid