title: [Helicobacter pylori infection and basal levels of serum gastrins in patients with duodenal ulcer and subjects with normal endoscopy].
abstract: BACKGROUND
  To study basal gastrin levels in duodenal ulcer patients and in those with normal endoscopy, according to Helicobacter pylori infection.
  
  
  METHODS
  Eighty-four duodenal ulcer patients and 164 with normal endoscopy were studied. Biopsy specimens were taken from gastric antrum and body, and investigated for microbiology (Gram stain and culture) and histology (hematoxilin-eosin stain). Basal gastrin levels were measured (RIA).
  
  
  RESULTS
  In duodenal ulcer patients the percentage of chronic gastritis was higher (p < 0.001) than in patients with normal endoscopy without H. pylori infection, and similar to patients infected by H. pylori. In patients with normal endoscopy (n = 164), those infected with H. pylori (n = 115) had higher (p = 0.02) gastrin levels (mean +/- SD) than non-infected (64 +/- 34 vs 51 +/- 14 pg/ml) and similar to duodenal ulcer patients (62 +/- 20 pg/ml). In the multiple regression model analysis H. pylori infection was the only variable which correlated with gastrin levels (regression coefficient 9.48 [SE = 4.59]; multiple correlation coefficient 0.22 [p = 0.008]). Additional variables (age, sex, duodenal ulcer) were not correlated with gastrin levels. Patients with chronic gastritis had higher gastrin levels (p < 0.01) than those with normal histologic mucosa.
  
  
  CONCLUSIONS
  In patients with normal endoscopy, those infected with H. pylori had significantly higher basal gastrin levels than non-infected individuals, and similar to duodenal ulcer patients. Therefore, hypergastrinaemia seems to be associated with H. pylori infection, and is not a distinctive feature of duodenal ulcer disease.
authors.affiliation: Servicio de Gastroenterología, Hospital Ramón y Cajal, Madrid.
authors.forename: J P
authors.initials: JP
authors.lastname: Gisbert
authors.forename: D
authors.initials: D
authors.lastname: Boixeda
authors.forename: T
authors.initials: T
authors.lastname: Vila
authors.forename: R
authors.initials: R
authors.lastname: Cantón
authors.forename: I
authors.initials: I
authors.lastname: Alvarez Baleriola
authors.forename: V
authors.initials: V
authors.lastname: Defarges
authors.forename: C
authors.initials: C
authors.lastname: Martín de Argila
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000097:blood*; D004724:Endoscopy; D005260:Female; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood; D016481:Helicobacter Infections / Q000097:blood* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D013270:Stomach / Q000382:microbiology
chemical_list: D005755:Gastrins
vernacular_title: Infección por Helicobacter pylori y concentraciones basales de gastrina sérica en pacientes con úlcera duodenal y en individuos con endoscopia normal.