title: [The effect of a synthetic analog of the gonadotropin-releasing hormone and of dopamine antagonists on the maturation and quality of loach ova].
abstract: We studied the effects of a synthetic analog of the gonadotropin-releasing hormone (aGnRH) and dopamine antagonists on oocyte maturation and ovulation in the loach Misgurnus fossilis L. under the conditions of artificial wintering. Marked differences in sensitivity of different fish to these drugs were found. The use of dopamine antagonists markedly (tens of times) decreased the effective dose of aGGGnRH. The sequence of efficiency of the dopamine antagonists was determined. Pimozide was most active and Sulpirid followed it. Haloperidol and Metaclopromide are markedly less active and they little differ from each other. When using little effective drugs or doses including little effective drugs or doses inducing a low percentage of ovulation, the time of ovulation was usually longer. No essential differences were found in the quality of eggs, obtained through stimulation with chorionic gonadotropin or aGnRH injected together with Pimozide or Sulpirid at the optimal doses.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Poponov
authors.forename: B F
authors.initials: BF
authors.lastname: Goncharov
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003531:Cypriniformes / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects; D010063:Ovum / Q000187:drug effects* / Q000254:growth & development
chemical_list: D006063:Chorionic Gonadotropin; D018492:Dopamine Antagonists; D007987:Gonadotropin-Releasing Hormone
vernacular_title: Vliianie sinteticheskogo analoga gonadotropin-rilizing gormona i antagonistov dofamina na sozrevanie i kachestvo iaĭtsekletok v'iuna.