title: An unusual case of autoimmune hemolytic anemia with reticulocytopenia, erythroid dysplasia, and an IgG2 autoanti-U.
abstract: BACKGROUND
  Autoantibodies with anti-U specificity, usually in combination with autoantibodies of other specificities, have occasionally been identified in association with autoimmune hemolytic anemia. A case of life-threatening autoimmune hemolytic anemia, characterized by several atypical features, including apparent intravascular hemolysis associated with an IgG2 anti-U, reticulocytopenia, and bone marrow dyserythropoiesis is described.
  
  
  METHODS
  A 36-year-old man with a severe case of acute-onset autoimmune hemolytic anemia was admitted to another hospital; he had a hematocrit of 15 percent, elevated bilirubin and lactate dehydrogenase, and positive direct and indirect antiglobulin tests. He received 7 units of incompatible red cells without improvement in hematocrit, and he was transferred to University Hospitals of Cleveland (OH). He was jaundiced and became syncopal in the sitting position. His serum was reddish pink; he had a hematocrit of 11.8 percent and a reticulocyte count of 2.5 percent. No spherocytes were observed in the peripheral blood smear. Shortly after admission, the hematocrit fell to 6.9 percent. He was given 3 units of "least-incompatible" red cells and was started on prednisone, with little improvement. An IgG2 autoanti-U was detected in his serum. Seven units of U- red cells were transfused over the next 4 days. The hematocrit improved to 23 percent and continued to rise without further transfusion. A bone marrow examination, initially revealing erythroid hyperplasia accompanied by dyserythropoiesis, became morphologically normal. Drug studies failed to show evidence of drug-related hemolysis. He remains well 2 years after discharge without evidence of recurrent hemolysis.
  
  
  CONCLUSIONS
  Severe life-threatening autoimmune hemolytic anemia, in this instance induced by an autoanti-U, may be associated with IgG2 autoantibody and characterized by apparent intravascular hemolysis and bone marrow dyserythropoiesis. Early treatment with U- blood, in addition to steroids, may be beneficial.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Roush
authors.forename: N S
authors.initials: NS
authors.lastname: Rosenthal
authors.forename: S L
authors.initials: SL
authors.lastname: Gerson
authors.forename: E M
authors.initials: EM
authors.lastname: Toy
authors.forename: P
authors.initials: P
authors.lastname: McCarthy
authors.forename: N V
authors.initials: NV
authors.lastname: Hirschler
authors.forename: R
authors.initials: R
authors.lastname: Yomtovian
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D001853:Bone Marrow / Q000473:pathology; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000473:pathology*; D006400:Hematocrit; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008951:MNSs Blood-Group System / Q000276:immunology*; D008297:Male; D017701:Reticulocyte Count
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D008951:MNSs Blood-Group System