Translocation of Yersinia enterocolitica through an endothelial monolayer by polymorphonuclear leukocytes.
An endothelial cell monolayer grown on a microporous membrane coated with basement membrane protein matrix was used to study translocation of yersinia-infected human polymorphonuclear leukocytes (PMNs). PMNs infected with one to eight bacteria were able to translocate living yersiniae from the upper chamber to the chemoattractant-containing lower chamber. This process may contribute to extravasation and dissemination of yersiniae in the infected host.
Rüssmann
H
H
Institute for Hygiene and Microbiology, University of Würzburg, Germany.
Ruckdeschel
K
K
Heesemann
J
J
D000818:Animals; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000382:microbiology*; D006801:Humans; D051379:Mice; D009068:Movement; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000382:microbiology* / Q000502:physiology*; D015008:Yersinia enterocolitica / Q000502:physiology*
D009240:N-Formylmethionine Leucyl-Phenylalanine