[Acute myopathy in an asthmatic patient treated with corticoids and muscle relaxants in the intensive care unit].
Acute myopathy occurred in a 49-year-old woman hospitalized in the intensive care unit for status asthmaticus. She was given high-dose intravenous steroid therapy and intubated. Pancuronium bromide was used for prolonged curarization. Flaccid quadriplegia developed with preservation of the deep tendon reflexes. Muscle biopsy showed a myogenic process with disorganized myofibrils and selective loss of thick myosin filaments. This mainly myogenic process would result from the toxic effect of corticosteroids favored by prolonged curarization although the effect of other factors still remains unknown.
Sangla
I
I
Service de Neurologie, CHU Timone, Marseille.
Pouget
J
J
Pellissier
J F
JF
Serratrice
G
G
D000208:Acute Disease; D000287:Administration, Topical; D000420:Albuterol / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001507:Beclomethasone / Q000009:adverse effects* / Q000627:therapeutic use; D003422:Critical Care; D004359:Drug Therapy, Combination; D004630:Emergencies; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced*; D009465:Neuromuscular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D013224:Status Asthmaticus / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009465:Neuromuscular Agents; D011239:Prednisolone; D001507:Beclomethasone; D000420:Albuterol
Myopathie aiguë chez une asthmatique traitée par corticoïdes et myorelaxants en réanimation.