title: Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
abstract: The vasoreactivity of dehydroevodiamine (1), evodiamine (2), and rutaecarpine (3), quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aorta with equal potency. Compound 3 produced a full (100%) nitric oxide-dependent vasodilatation, whereas 2 and 1 produced a partially endothelium-dependent effect, 50% and 10%, respectively. At the same time, I and 2 may also act by other mechanisms, including probably an alpha1-adrenoceptor blocking action and a 5-HT antagonizing action, respectively.
authors.affiliation: National Research Instituter of Chinese Medicine, Tapei Hsein, Taiwan.
authors.forename: W F
authors.initials: WF
authors.lastname: Chiou
authors.forename: J F
authors.initials: JF
authors.lastname: Liao
authors.forename: C F
authors.initials: CF
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010936:Plant Extracts; D011799:Quinazolines / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D014665:Vasodilator Agents / Q000302:isolation & purification / Q000494:pharmacology*; D052999:Quinazolinones
chemical_list: D000470:Alkaloids; D001120:Arginine; D002121:Calcium Channel Blockers; D004791:Enzyme Inhibitors; D026121:Indole Alkaloids; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D010936:Plant Extracts; D011799:Quinazolines; D018340:Receptors, Adrenergic, alpha-1; D011985:Receptors, Serotonin; D014665:Vasodilator Agents; C028633:dehydroevodiamine; C028632:rutecarpine; D052999:Quinazolinones; C049639:evodiamine