title: Thrombogenesis.
abstract: Thrombosis occurs when there is a breakdown in the balance between thrombogenic factors and protective mechanisms. The thrombogenic factors may be exogenous (e.g. trauma, surgery), endogenous (e.g. cancer, vascular diseases) or both (e.g. atherosclerosis, complicated pregnancy). Defects in the protective mechanisms may be congenital (e.g. factor V R506Q-mutation, deficiency of protein C, protein S or antithrombin) or acquired (e.g. lupus anticoagulans, deficiency of antithrombin in nephrosis). In recent years, research in thromboembolic diseases has been overwhelmed with new observations, rendering it worthwhile to put efforts into the evaluation of thrombotic mechanisms in individuals suffering from or predisposed to thromboembolic diseases. Such efforts will pave the way for more effective prophylaxis in thrombosis-prone patients, more specific treatment of thrombotic diseases, and the mastering of recurrent thrombosis.
authors.affiliation: The Coagulation Laboratory, Copenhagen University Hospital Gentofte Amtssygehus, Denmark.
authors.forename: J D
authors.initials: JD
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008297:Male; D015539:Platelet Activation / Q000502:physiology; D011247:Pregnancy; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
chemical_list: D017152:Antibodies, Antiphospholipid