[Percutaneous absorption of venenum bufonis in vitro].
V-C horizontal diffusion cell and HPLC determination have been used to study the effect of 1,2-propanediol and azone on the percutaneous absorption Venenum Bufonis. The contents of resibufogenin have been determined through mouse skin in vitro by HPLC. The results indicate that the contents get increased when 1,2-propanediol is added and that azone can shorten the lag time of percutaneous absorption of resibufogenin through mouse skin in vitro.
Yu
J
J
Jiangxi Provincial Institute of Traditional Chinese Medicine and Materia Medica, Nanchang.
Cheng
Y
Y
Feng
Q
Q
Jin
K
K
D000664:Amphibian Venoms / Q000302:isolation & purification / Q000493:pharmacokinetics*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002023:Bufo bufo; D002316:Cardiotonic Agents / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*
D000664:Amphibian Venoms; D001381:Azepines; D002316:Cardiotonic Agents; D011409:Propylene Glycols; C035229:laurocapram; D019946:Propylene Glycol