title: Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity.
abstract: We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/Pl rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/Pl rats fed the HF diet. These data suggest that OM and S5B/Pl rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: G A
authors.initials: GA
authors.lastname: Bray
authors.forename: D A
authors.initials: DA
authors.lastname: York
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D008099:Liver / Q000294:innervation; D008297:Male; D009765:Obesity / Q000235:genetics / Q000523:psychology*; D011773:Pyruvates / Q000494:pharmacology*; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D004041:Dietary Fats; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid