title: [Significance of ursodeoxycholic acid in the eradication of Helicobacter pylori].
abstract: In this pilot study we investigated the value of a fourteen-day regimen with amoxicillin (1 g bid), ranitidine (300 mg/d) and ursodeoxycholic acid (300 mg tid) in eradicating Helicobacter pylori. 15 patients with non-ulcer dyspepsia (reactive CLO test, positive histology or 13C urea breath test) were enrolled. Helicobacter pylori was eradicated in 6 of 13 patients (13C urea breath test 4 weeks after the end of treatment). 2 patients were not followed up because of too short treatment (< 1 week). Only 5/15 patients had no side effects (33%). These results strongly suggest that ursodeoxycholic acid in this application regimen is not of use in eradicating Helicobacter pylori.
authors.affiliation: Abteilung für Gastroenterologie, Kantonsspital St. Gallen.
authors.forename: J
authors.initials: J
authors.lastname: Binek
authors.forename: P
authors.initials: P
authors.lastname: Hildebrand
authors.forename: C
authors.initials: C
authors.lastname: Beglinger
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage; D010865:Pilot Projects; D011899:Ranitidine / Q000008:administration & dosage; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000897:Anti-Ulcer Agents; D005765:Gastrointestinal Agents; D010406:Penicillins; D014580:Ursodeoxycholic Acid; D000658:Amoxicillin; D011899:Ranitidine
vernacular_title: Bedeutung von Ursodeoxycholsäure bei der Eradikation von Helicobacter pylori.