[Comparative characteristics of a test system for detecting antibodies to hepatitis C virus].
The sensitivities and specificities of enzyme immunoassay (EIA) kits for the detection of antibodies to hepatitis C virus (HCV) were compared in donor blood screening. A total of 3308 donors were examined using Akvapast immunodiagnosticum (St. Petersburg), lot 12. Anti-HCV antibodies were detected in 43 (1.3%) subjects. Blood sera of these donors were additionally investigated using other lots of Akvapast, Hepascan (Bioservice, Moscow), Blot-0.5 (Bioservice, Moscow), and immunoComb (France). The studies demonstrated that none of the agents used can be acknowledged as ideally sensitive and specific for the detection of anti-HCV antibodies. Maximally sensitive diagnostic kits should be preferred for the screening of donors of blood components and for other mass surveys. Highly-specific test systems are advisable for profound examinations and diagnostic monitoring. The creation of a system of reference and expert diagnosis of hepatitis C remains a pressing task.
Zhiburt
E B
EB
Bel'gesov
N V
NV
Danil'chenko
V V
VV
Serebrianaia
N B
NB
Potepun
V K
VK
Sidorkevich
S V
SV
Vasiliuk
V B
VB
Zhuravlev
K Iu
KIu
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005069:Evaluation Studies as Topic; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
D018937:Hepatitis C Antibodies; D011933:Reagent Kits, Diagnostic
Sravnitel'naia kharakteristika test-sistem dlia opredeleniia antitel k virusu gepatita C.