Pathology of the vessels in cerebral amyloid angiopathy.
We review here current data on congophilic amyloid angiopathy (congophilic angiopathy) or cerebral amyloid angiopathy in both transmissible and non-transmissible cerebral amyloidoses. A beta peptide is the amyloid in congophilic angiopathy of Alzheimer's disease, and in majority of cases of Creutzfeld-Jakob disease and Gerstmann-Sträussler-Scheinker disease. A variant of Cystatin C is the amyloid in hereditary cerebral hemorrhage with amyloidosis-Icelandic type. The only exception is a curious GSS-like family from Japan characterized by 145 stop codon at the PRNP gene. Both molecular pathology and neuropathology are covered by this review.
Liberski
P P
PP
Laboratory of Electron Microscopy and Neuropathology, School of Medicine, Lódź.
Barcikowska
M
M
D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000032:analysis; D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000209:etiology / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans
D000682:Amyloid; D016229:Amyloid beta-Peptides