title: Recent developments in the theory of protein folding: searching for the global energy minimum.
abstract: Statistical mechanical theories and computer simulation are being used to gain an understanding of the fundamental features of protein folding. A major obstacle in the computation of protein structures is the multiple-minima problem arising from the existence of many local minima in the multidimensional energy landscape of the protein. This problem has been surmounted for small open-chain and cyclic peptides, and for regular-repeating sequences of models of fibrous proteins. Progress is being made in resolving this problem for globular proteins.
authors.affiliation: Baker Laboratory of Chemistry, Cornell University, Ithaca, NY 14853-1301, USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Scheraga
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D015233:Models, Statistical; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011506:Proteins