title: 2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Williams
authors.forename: T M
authors.initials: TM
authors.lastname: Ciccarone
authors.forename: S C
authors.initials: SC
authors.lastname: MacTough
authors.forename: R L
authors.initials: RL
authors.lastname: Bock
authors.forename: M W
authors.initials: MW
authors.lastname: Conner
authors.forename: J P
authors.initials: JP
authors.lastname: Davide
authors.forename: K
authors.initials: K
authors.lastname: Hamilton
authors.forename: K S
authors.initials: KS
authors.lastname: Koblan
authors.forename: N E
authors.initials: NE
authors.lastname: Kohl
authors.forename: A M
authors.initials: AM
authors.lastname: Kral
authors.forename: S D
authors.initials: SD
authors.lastname: Mosser
authors.forename: C A
authors.initials: CA
authors.lastname: Omer
authors.forename: D L
authors.initials: DL
authors.lastname: Pompliano
authors.forename: E
authors.initials: E
authors.lastname: Rands
authors.forename: M D
authors.initials: MD
authors.lastname: Schaber
authors.forename: D
authors.initials: D
authors.lastname: Shah
authors.forename: F R
authors.initials: FR
authors.lastname: Wilson
authors.forename: J B
authors.initials: JB
authors.lastname: Gibbs
authors.forename: S L
authors.initials: SL
authors.lastname: Graham
authors.forename: G D
authors.initials: GD
authors.lastname: Hartman
authors.forename: A I
authors.initials: AI
authors.lastname: Oliff
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D019883:Alkyl and Aryl Transferases; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051231:Farnesyltranstransferase; D051379:Mice; D008819:Mice, Nude; D008968:Molecular Conformation; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011106:Polyisoprenyl Phosphates / Q000378:metabolism; D017368:Protein Prenylation; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology; D012717:Sesquiterpenes; D014166:Transferases / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010879:Piperazines; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; C004808:farnesyl pyrophosphate; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D051231:Farnesyltranstransferase; D018631:ras Proteins