title: The clozapine experience from a family perspective.
abstract: OBJECTIVE
  To examine how the lives of family members of clozapine-treated patients with schizophrenia have been affected by this treatment.
  
  
  METHODS
  Through the use of a questionnaire and an interview of family members, this qualitative study focused on the families' perceptions of change in their family member and the impact on the family unit.
  
  
  RESULTS
  Fourteen patients and their family members participated. The family interview was conducted an average of 1.78 years after clozapine initiation (range 0.58 years to 3.73 years). Global ratings of behavioural change were positively and significantly correlated between all raters: patients, family members, and clinicians. Family members were positive about clozapine's effect on their relatives and the impact on the family.
  
  
  CONCLUSIONS
  A positive response to clozapine decreases the burden on the family. This is in part the result of a decreased need for rehospitalization.
authors.affiliation: Psychiatry, University of Calgary, Alberta.
authors.forename: R A
authors.initials: RA
authors.lastname: Dickson
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: J T
authors.initials: JT
authors.lastname: Dalby
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D017281:Cost of Illness; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D010552:Personality Assessment; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine