title: Mapping of the dilute-opisthotonus (dop) gene on chromosome 8 of the rat.
abstract: The rat dilute-opisthotonus (dop) autosomal recessive gene, causing ataxia and coat color dilution, was mapped on chromosome 8 by PCR-amplified microsatellite markers. To facilitate the linkage analysis, an intersubspecific cross with a Japanese wild rat strain was used. The recombination frequencies were 12.8% between Apoc3 and dop, and 32.1% between dop and Mylc1v. The following order of three genes is proposed; Apoc3-dop-Mylc1v. This mutation appears to be homologous to dilute-lethal (d1) of the mouse in terms of clinical symptoms, coat color effect and chromosomal location of the gene loci. Key words: ataxic mutant rat, dilute-opisthotonus (dop), gene mapping.
authors.affiliation: School of Agricultural Sciences, Nagoya University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: Y
authors.initials: Y
authors.lastname: Kanou
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: N
authors.initials: N
authors.lastname: Wakasugi
authors.forename: M
authors.initials: M
authors.lastname: Inouye
authors.forename: H
authors.initials: H
authors.lastname: Yamamura
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics*; D004247:DNA / Q000302:isolation & purification; D004587:Electrophoresis, Agar Gel; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive / Q000235:genetics; D008040:Genetic Linkage; D008297:Male; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004247:DNA