title: [Enzymatic activity of the pancreas and small intestinal mucosa in modelling of toxic hepatitis by administration of heliotrine].
abstract: The activity of pancreatic (alpha-amylase, protease, and lipase) and enteral (maltase, glycyl-L-leucine dipeptidase, monoglyceride lipase) was studied in the experiments on adult male Wistar rats weighting 350 +/- 35 g 1-3, 7, 10, 30, 60, and 90 days after injection of a single dose of 25 mg per 100 g body weight. Acute heliotrine intoxication (in a toxic hepatitis model) was shown to lead to a marked decrease in the activities of both pancreatic and intestinal enzymes. It is suggested that the changes may be associated with the direct action of heliotrine on the pancreas and small intestinal mucosa or with hepatic failure.
authors.forename: Kh Ia
authors.initials: KhIa
authors.lastname: Karimov
authors.forename: A N
authors.initials: AN
authors.lastname: Daniiarov
authors.forename: M M
authors.initials: MM
authors.lastname: Usmanov
authors.forename: A I
authors.initials: AI
authors.lastname: Demidova
authors.forename: A N
authors.initials: AN
authors.lastname: Zul'pikarieva
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000209:etiology; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology; D011763:Pyrrolizidine Alkaloids; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011763:Pyrrolizidine Alkaloids; C010178:heliotrine
vernacular_title: Fermentativnaia aktivnost' podzheludochnoĭ zhelezy i slizistoĭ obolochki tonkoĭ kishki pri modelirovanii toksicheskogo gepatita vvedeniem geliotrina.