title: Effects of follicle-stimulating hormone administration on oestradiol-induced cystic ovaries in guinea pigs.
abstract: A consistent defect in follicle-stimulating hormone (FSH) secretion is seen in humans with Polycystic Ovarian Syndrome (PCOS); therefore, we evaluated whether Metrodin (a highly purified urinary FSH) administration concurrent with cyst induction or following cyst induction inhibits estrogen-induced cyst development and augments ovarian follicular growth in an established guinea pig model. All animals in these studies received subcutaneous implants containing oestradiol-17 beta (E2)-filled Silastic capsules for a 48-hour period. Guinea pigs in study #1 were administered four 0.25 mL injections of FSH or placebo at twelve-hour intervals simultaneously with the E2 treatment; guinea pigs assigned to study #2 were administered four 0.25 mL injections of FSH or placebo at twelve-hour intervals following the induction of the cystic condition by E2. Exogenous FSH appears to negate cyst formation when superimposed upon the cyst-inducing agent (E2). Further, treatment with FSH augmented the number of mid-sized follicles in both paradigms. This study is the first to establish evidence of an anti-cystic effect of FSH in an animal model.
authors.affiliation: Department of Biological Sciences, University of Wisconsin-Milwaukee 53201, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Campion
authors.forename: A L
authors.initials: AL
authors.lastname: Trewin
authors.forename: R J
authors.initials: RJ
authors.lastname: Hutz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006168:Guinea Pigs; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone