title: Evaluating the impact of exposure to environmental contaminants on human health.
abstract: Humans are exposed daily to low concentrations of many different chemical substances, natural and some man-made. Although many of these substances can be toxic at high levels, typical exposures are far below the effect levels. The responses produced by man-made aromatic hydrocarbon receptor agonists, such as dioxins, polychlorinated dibenzofurans, coplanar polychlorinated biphenyls, and polycyclic aromatic hydrocarbons, are also produced, often to greater extents [corrected], by naturally occurring constituents of fried meat, cabbage, broccoli, cauliflower, cocoa, and curry. Our society seems to be concerned about the health risks associated only with the synthetic chemicals, regardless of their proportional contribution to the total agonist activity, and regulates on the basis of such concerns. It would be more protective of the public health to determine acceptable concentrations for each type of response, regardless of the origin of the inducing agent, and issue advisories or regulations accordingly.
authors.affiliation: General Electric Corporate R&D, Schenectady, NY 12301-0008, USA. Silkworth@crd.ge.com
authors.forename: J B
authors.initials: JB
authors.lastname: Silkworth
authors.forename: J F
authors.initials: JF
authors.lastname: Brown
mesh_terms: D000818:Animals; D004147:Dioxins; D004781:Environmental Exposure; D005506:Food Contamination; D006801:Humans; D011078:Polychlorinated Biphenyls; D012307:Risk Factors; D015262:Xenobiotics
chemical_list: D004147:Dioxins; D015262:Xenobiotics; D011078:Polychlorinated Biphenyls