[Diagnosis and targeting therapy of colorectal cancer using antibody].
Application of monoclonal antibody for diagnosis and therapy of colorectal cancer was reviewed. The history and present status of radioimmunoimaging of cancer were presented. Immuno-guided surgery using radiolabeled antibody and hand-aided detector during surgery is a promising approach for complete excision of cancerous region. Also, a new antibody labeling method using a micro-magnet instead of radioisotopes may lead to a new era in immunodiagnosis of cancer. Finally, immunotargeting chemotherapy using antibody-anticancer drug conjugates was reviewed. A new type of immunoconjugate composed of human/mouse chimeric antibody and Neocarzinostatin seems to be one of the most promising drug formulas for immunotargeting chemotherapy.
Yamaguchi
T
T
Dept. of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Kitamura
K
K
Otsuji
E
E
Kotani
T
T
Kato
M
M
Yata
Y
Y
Okamoto
K
K
Nishi
H
H
Ichikawa
D
D
Yamamoto
K
K
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D016719:Radioimmunodetection; D009353:Zinostatin / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D009353:Zinostatin