title: Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages.
abstract: We have investigated the cytotoxic and chemotactic potencies of malondialdehyde (MDA), hexanal, 4-hydroxyhexenal (HHE), 4-hydroxynonenal (HNE) and 4-hydroxyoctenal (HOE), which are aldehydes found in oxidised low density lipoprotein (LDL), for human monocyte-macrophages. They were toxic in the following order: hexanal<HHE= HOE< HNE. HNE was toxic at 20 microM and chemotactic at 2.5 microM. The other aldehydes tested had no chemoattractant activity. Our results suggest that HNE arising from LDL oxidation could attract monocytes into the human atherosclerotic lesion. A direct cytotoxic role of aldehydes in foam cell death in the lesion is less likely.
authors.affiliation: Division of Cellular Pathology, University of Cambridge, UK.
authors.forename: K
authors.initials: K
authors.lastname: Müller
authors.forename: S J
authors.initials: SJ
authors.lastname: Hardwick
authors.forename: C E
authors.initials: CE
authors.lastname: Marchant
authors.forename: N S
authors.initials: NS
authors.lastname: Law
authors.forename: G
authors.initials: G
authors.lastname: Waeg
authors.forename: H
authors.initials: H
authors.lastname: Esterbauer
authors.forename: K L
authors.initials: KL
authors.lastname: Carpenter
authors.forename: M J
authors.initials: MJ
authors.lastname: Mitchinson
mesh_terms: D000447:Aldehydes / Q000378:metabolism / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000378:metabolism / Q000502:physiology*; D003603:Cytotoxins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism* / Q000502:physiology; D008264:Macrophages / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D002630:Chemotactic Factors; D003603:Cytotoxins; D008077:Lipoproteins, LDL; C063409:4-hydroxyhexenal; C046538:4-hydroxy-2-octenal; D008315:Malondialdehyde; C010463:n-hexanal; C027576:4-hydroxy-2-nonenal