title: Severe systemic reactions attributed to the acetone-inactivated parenteral typhoid vaccine.
abstract: Typhoid vaccine is recommended for people traveling to areas where they may be exposed to contaminated food and/or water. Two different parenteral forms of the vaccine have been utilized. We report five active duty patients with severe systemic reactions to the acetone-inactivated form of typhoid vaccine. The patients presented with very similar physical exam findings and laboratory abnormalities. Alternative typhoid vaccines that are less reactogenic are now available for use.
authors.affiliation: Internal Medicine Department, U.S. Naval Hospital, Pensacola, FL 32512-0003, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Hoyt
authors.forename: D S
authors.initials: DS
authors.lastname: Herip
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000628:therapy; D007273:Injections, Intramuscular; D008297:Male; D008889:Military Personnel; D014435:Typhoid Fever / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014436:Typhoid-Paratyphoid Vaccines