Ventilatory response to hypoxia in humans. Influences of subanesthetic desflurane.
BACKGROUND
At low dose, the halogenated anesthetic agents halothane, isoflurane, and enflurane depress the ventilatory response to isocapnic hypoxia in humans. In the current study, the influence of subanesthetic desflurane (0.1 minimum alveolar concentration [MAC]) on the isocapnic hypoxic ventilatory response was assessed in healthy volunteers during normocapnia and hypercapnia.


METHODS
A single hypoxic ventilatory response was obtained at each of 4 target end-tidal partial pressure of oxygen concentrations: 75, 53, 44, and 38 mmHg, before and during 0.1 MAC desflurane administration. Fourteen subjects were tested at a normal end-tidal partial pressure of carbon dioxide (43 mmHg), with 9 subjects tested at an end-tidal carbon dioxide concentration of 49 mmHg (hypercapnia). The hypoxic sensitivity (S) was computed as the slope of the linear regression of inspired minute ventilation (V1) on (100-SPO2). Values are mean +/- SE.


RESULTS
Sensitivity was unaffected by desflurane during normocapnia (control: S = 0.45 +/- 0.07 l.min-1.%-1 vs. 0.1 MAC desflurane: S = 0.43 +/- 0.09 l.min-1.%-1). With hypercapnia S decreased by 30% during desflurane inhalation (control: S = 0.74 +/- 0.09 l.min-1.%-1 vs. 0.1 MAC desflurane: S = 0.53 +/- 0.06 l.min-1.%-1; P < 0.05).


CONCLUSIONS
On the basis of the data, subanesthetic desflurane has no detectable effect on the normocapnic hypoxic ventilatory response sensitivity. However, the carbon dioxideinduced augmentation of the hypoxic response was reduced. This indicates that subanesthetic desflurane effects the chemoreceptors at the carotid bodies.
Dahan
A
A
Department of Anesthesiology, Leiden University Hospital, The Netherlands. dahan@rullf2.medfac.leidenuniv.nl
Sarton
E
E
van den Elsen
M
M
van Kleef
J
J
Teppema
L
L
Berkenbosch
A
A
D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000032:analysis; D000077335:Desflurane; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D010100:Oxygen / Q000032:analysis; D012119:Respiration / Q000187:drug effects*
D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D000077335:Desflurane; D007530:Isoflurane; D010100:Oxygen