title: [Glycoforms of alpha-1 antichymotrypsin in infectious process. Diagnostic value and follow-up].
abstract: OBJECTIVE
  Three alpha 1-antichymotrypsin (alpha 1-ACT) glycans have been identified. We followed their levels during the septic processes in 24 patients in order to determine their diagnostic value in correlation with C-reactive peptide in patients with infection.
  
  
  METHODS
  Sera were collected for assay on days 0, 3 and 6 after starting antibiotics. Erythrocyte sedimentation rate, alpha 1-ACT and C-reactive protein were determined.
  
  
  RESULTS
  Erythrocyte sedimentation rate changed little while C-reactive protein fell sharply as in other inflammatory processes. Crossed immunoaffinoelectrophoresis showed a decreased formation of the Con-A non reactive fraction which disappeared rapidly after initiating antibiotics. Glycan microheterogeneity returned to normal at 6 days while C-reactive protein and alpha 1-ACT were still elevated.
  
  
  CONCLUSIONS
  Synthesis and glycosylation of alpha 1-ACT are independent. Study of alpha 1-ACT glycan microheterogeneity may provide a useful test in the diagnosis of inflammatory processes of unknown origin and may be helpful in following-up patients with sepsis.
authors.affiliation: Service de Médecine interne, Hôpital Claude Huriez, CHRU, Lille.
authors.forename: E
authors.initials: E
authors.lastname: Hachulla
authors.forename: A
authors.initials: A
authors.lastname: Laine
authors.forename: T
authors.initials: T
authors.lastname: Blaringhem
authors.forename: V
authors.initials: V
authors.lastname: Canva-Delcambre
authors.forename: B
authors.initials: B
authors.lastname: Devulder
authors.forename: P
authors.initials: P
authors.lastname: Degand
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D015415:Biomarkers; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006031:Glycosylation; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D000514:alpha 1-Antichymotrypsin; D002097:C-Reactive Protein
vernacular_title: Etude des glycoformes de alpha 1-antichymotrypsine au cours des processus infectieux. Valeur diagnostique et suivi évolutif.