Antagonizing the differentiation and functions of human T helper type 2 cells.
Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.
de Vries
J E
JE
Human Immunology Department, Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.
Carballido
J M
JM
Sornasse
T
T
Yssel
H
H
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis; D018793:Interleukin-13 / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D016513:Mice, SCID; D018448:Models, Immunological; D018123:Receptors, Interleukin / Q000037:antagonists & inhibitors*; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism*
D018793:Interleukin-13; D018123:Receptors, Interleukin; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma