title: Is surgery for aortic stenosis justified in patients over 75 years of age?
abstract: The upper age limit for cardiac surgery has constantly been extended since the 1980's, with the most pronounced extension observed in surgery of the calcified aortic stenosis (CAS). The aim of this study was to examine whether surgery is beneficial to the elderly population in terms of hospital mortality, long-term survival and quality of life. Between January 1989 and October 1992, 95 patients over 75 years of age underwent aortic valvular replacement (AVR) for CAS. There were 54 male and 41 female patients with a mean age of 79.7 +/- 2.8 years. All of them suffered from isolated or predominant CAS, associated with a coronary lesion requiring additional bypass procedures in 14 cases. Before surgery 67% of the patients were in NYHA class III and IV and 30% of them had suffered from acute pulmonary edema. Surgical priority was urgent in 10 patients. Mean aortic clamp time was of 55 minutes for the isolated CAS and 78 minutes for the bypass-associated CAS. A Carpentier-Edwards supra-annular bioprosthesis was implanted in 95.7% of the cases, associated with coronary bypass in 14 cases, with a mean of 1.6 bypasses per patient. Global hospital mortality was 11.5%. Emergency surgery was a predictive factor of in hospital mortality in multivariate analysis. Among the 84 survivors, 12 died secondarily, 4 of them due to cardiac causes during the follow-up period (26 +/- 4 months); similar to the mortality rate of the global population for the same age. The factors responsible for this late mortality in multivariate analysis were poor left ventricular status and diabetes mellitus. Survivor's quality of life is excellent with 78.6% of patients termed class I, autonomous and free of sequelae.
  
  
  CONCLUSIONS
  despite an operative mortality rate much higher than in patients under 70, AVR for CAS is justified even in patients over 75 years as it offers a good quality of survival and a life expectancy identical to that of the general population of the same age.
authors.affiliation: Department of Thoracic and Cardiovascolar Surgery, Hôpital Saint-Jacques, Besançon, France.
authors.forename: S
authors.initials: S
authors.lastname: Chocron
authors.lastname: Etievent JPh
authors.forename: F
authors.initials: F
authors.lastname: Clement
authors.forename: K
authors.initials: K
authors.lastname: Alwan
authors.forename: M
authors.initials: M
authors.lastname: Neidhardt
authors.forename: C
authors.initials: C
authors.lastname: Taberlet
authors.forename: N
authors.initials: N
authors.lastname: Schipman
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000401:mortality / Q000601:surgery*; D002114:Calcinosis / Q000150:complications / Q000401:mortality / Q000601:surgery; D001026:Coronary Artery Bypass / Q000401:mortality; D003327:Coronary Disease / Q000150:complications / Q000401:mortality / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D008017:Life Expectancy; D008297:Male; D015999:Multivariate Analysis; D018579:Patient Selection; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate