title: Regulation of dynein-driven microtubule sliding by an axonemal kinase and phosphatase in Chlamydomonas flagella.
abstract: The following is a summary of physiological and pharmacological studies of the regulation of dynein-driven microtubule sliding in Chlamydomonas flagella. The experimental basis for the study is described, and data indicating that an axonemal cAMP-dependent protein kinase can regulate inner arm dynein activity are reviewed. In addition, preliminary data are summarized indicating that an axonemal type 1 phosphatase can also regulate dynein-drive microtubule sliding velocity. It is predicted that the protein kinase, phosphatase, and an inner dynein arm component form a regulatory complex in the axoneme.
authors.affiliation: Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: G
authors.initials: G
authors.lastname: Habermacher
authors.forename: W S
authors.initials: WS
authors.lastname: Sale
mesh_terms: D000818:Animals; D002696:Chlamydomonas / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology*; D004398:Dyneins / Q000378:metabolism*; D005407:Flagella / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D010766:Phosphorylation; D010940:Plant Proteins / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015800:Protozoan Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D010940:Plant Proteins; D015800:Protozoan Proteins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D010749:Phosphoprotein Phosphatases; D004398:Dyneins