[Immunoendocrine homeostasis in mice after local irradiation of immune and endocrine system organs].
Immunoendocrinological studies were carried out in mice during a year after local X-ray irradiation of thymus, hypothalamus-hypophysis, gonads, spleen and thigh muscles. Irradiation of the organs caused the stress regardless of the dose and localisation. No stable immunoendocrinological changes was observed in exposed spleen and thigh muscles. Post-irradiation disfunction of the central and peripheral endocrine gland (hypothalamus-hypophysis, gonads, thymus) induced alterations in function of other endocrine glands and depressive state of the endocrine system. Functional deviations in immune and endocrine systems has a phase character with some dose dependence. The effect of combined irradiation of thymus and hypothalamus-hypophysis is similar to those under separate irradiation.
Savina
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D000818:Animals; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004702:Endocrine Glands / Q000528:radiation effects*; D006706:Homeostasis / Q000528:radiation effects; D007030:Hypothalamo-Hypophyseal System / Q000528:radiation effects; D007107:Immune System / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009132:Muscles / Q000528:radiation effects; D011829:Radiation Dosage; D013154:Spleen / Q000528:radiation effects; D013737:Testis / Q000528:radiation effects; D013950:Thymus Gland / Q000528:radiation effects
Immunoéndokrinnyĭ gomeostaz u mysheĭ posle lokal'nogo oblucheniia organov immunnoĭ i éndokrinnoĭ sistem.