title: Three-dimensional reconstruction of benign lymphoid aggregates in bone marrow trephines.
abstract: Distinguishing between deposits of low-grade non-Hodgkin's lymphoma and benign lymphoid aggregates in bone marrow trephine sections is a recognized problem in haematopathology. To test the hypothesis that benign lymphoid aggregates do not make contact with a trabecular surface, three-dimensional models were constructed of five serially sectioned bone marrow trephines, containing a total of 19 lymphoid aggregates known to be benign. The computer-generated images showed that benign lymphoid aggregates were located in the central marrow space and did not become paratrabecular. This suggests that a paratrabecular location may help in some cases to distinguish deposits of low-grade non-Hodgkin's lymphoma from benign lymphoid aggregates.
authors.affiliation: Department of Histopathology, King's College School of Medicine and Dentistry, London, U.K.
authors.forename: J R
authors.initials: JR
authors.lastname: Salisbury
authors.forename: M H
authors.initials: MH
authors.lastname: Deverell
authors.forename: M J
authors.initials: MJ
authors.lastname: Cookson
mesh_terms: D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination / Q000379:methods*; D002449:Cell Aggregation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged