Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia.
Intercellular adhesion molecule 1 (ICAM-1) is a member of the immunoglobulin superfamily that interacts with two integrins, LFA-1 and Mac-1. These interactions are critical for leukocyte extravasation into inflamed tissue. To assess the role of ICAM-1 expression in the pathogenesis of bacterial infection, homozygously mutant mice lacking the ICAM-1 gene were exposed to Staphylococcus aureus. Within 6 days after inoculation 50% of the animals in the ICAM-1(-/-) group, but none of the controls, had died. Despite the high level of mortality, ICAM-1(-/-) mice developed less frequent and less severe arthritis than their wild-type littermates. In agreement, normal mice inoculated with staphylococci and administered anti-ICAM-1 antibodies exhibited a higher frequency of mortality but less severe arthritis than the controls. Our results indicate that ICAM-1 on the one hand provides protection against systemic disease but on the other hand aggravates the local disease manifestation.
Verdrengh
M
M
Department of Clinical Immunology, University of Göteborg, Sweden.
Springer
T A
TA
Gutierrez-Ramos
J C
JC
Tarkowski
A
A
D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D016470:Bacteremia / Q000276:immunology*; D016207:Cytokines / Q000097:blood; D007136:Immunoglobulins / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D013203:Staphylococcal Infections / Q000209:etiology* / Q000276:immunology* / Q000382:microbiology; D013997:Time Factors
D016207:Cytokines; D007136:Immunoglobulins; D018799:Intercellular Adhesion Molecule-1