[Treatment of experimental herpesvirus infection with nonsteroidal anti-inflammatory agents].
The therapeutic effect of nonsteroid antiinflammatory drugs (pyrazolone and salicylate derivatives) and their combinations with acyclovir was assessed in experimental herpesvirus infection in cell culture and in mice. A combination of 4-iodoantipyrine and acyclovir protected mice from herpesvirus encephalitis. This effect was associated with a decrease of the level of the virus in mouse brain and an increase of the titers of serum interferon and virus neutralizing antibodies.
Evstropov
A N
AN
Iavorovskaia
V E
VE
Galegov
G A
GA
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006561:Herpes Simplex / Q000188:drug therapy* / Q000821:virology; D018259:Herpesvirus 1, Human; D051379:Mice; D014709:Vero Cells
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D000983:Antipyrine; C008135:iodoantipyrine; D000212:Acyclovir
Lechenie éksperimental'noĭ gerpeticheskoĭ infektsii nesteroidnymi protivovospalitel'nymi sredstvami.