title: AILD-like dysplasia transformed in AILD-type T cell lymphoma in an HTLV-1 carrier: usefulness of interferon-alpha.
abstract: A 61-year-old Japanese woman who was an HTLV-1 carrier had angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-like dysplasia that transformed into AILD-type lymphoma after 3 years. Complete remission was achieved with interferon-alpha (IFN-alpha) treatment following a previous combination of anticancer drugs. IFN-alpha was also effective for maintenance therapy after this complete, albeit transient, remission. From clinical and pathological studies on AILD patients, it appears that AILD may in some cases be the consequence of an immune dysfunction caused by HTLV-1 infection and that AILD-type lymphoma is a malignant disorder of peripheral T cell clones different from those T cells incorporating the HTLV-1 virus.
authors.affiliation: Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kozuru
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Takahira
authors.forename: N
authors.initials: N
authors.lastname: Uike
authors.forename: K
authors.initials: K
authors.lastname: Ohoshima
authors.forename: M
authors.initials: M
authors.lastname: Takeshita
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002353:Carrier State; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D015490:HTLV-I Infections; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000473:pathology / Q000821:virology*; D016130:Immunophenotyping; D016898:Interferon-alpha / Q000627:therapeutic use*; D007564:Japan; D007621:Karyotyping; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000628:therapy / Q000821:virology*; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D016898:Interferon-alpha