title: Pentosan polysulfate-induced thrombocytopenia: a case diagnosed with an ELISA test used for heparin-induced thrombocytopenia.
abstract: We report a patient who developed severe thrombocytopenia and ischemic stroke following pentosan polysulfate treatment. An ELISA test employed in type-II heparin-induced thrombocytopenia was highly positive. To our knowledge, this is the first case in which this test has been performed in a pentosan polysulfate-induced thrombocytopenia (PIT). Our data suggest that the antibody against pentosan polysulfate-platelet complex also cross-reacts with heparin-platelet factor 4 complex. Due to its greater sensitivity and wider availability, this ELISA test should be used in cases where PIT is suspected.
authors.affiliation: Department of Neurology, Hospital de Sant Pau, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gironell
authors.forename: A
authors.initials: A
authors.lastname: Altés
authors.forename: A
authors.initials: A
authors.lastname: Arboix
authors.forename: J
authors.initials: J
authors.lastname: Fontcuberta
authors.forename: C
authors.initials: C
authors.lastname: Muñoz
authors.forename: J L
authors.initials: JL
authors.lastname: Martí-Vilalta
mesh_terms: D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006493:Heparin; D006801:Humans; D008875:Middle Aged; D010426:Pentosan Sulfuric Polyester / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis; D013924:Thrombophlebitis / Q000188:drug therapy
chemical_list: D010426:Pentosan Sulfuric Polyester; D006493:Heparin