Mast cell mediators excite the afferents of cat small intestine.
The influence of intra-arterial injections of 5-hydroxytryptamine, histamine and prostaglandin E2 on afferent impulse activity of mesenteric nerves of small intestine was studied. In anaesthetized cats 5-hydroxytryptamine (10(-5)-10(-4) M) and histamine (10(-5)-10(-3) M) were shown to increase the impulse activity in a dose-dependent manner. Metergolin, 5-hydroxytryptamine antagonist, suppressed the effect of 5-hydroxytryptamine. Clemastine and cimetidine, antagonists of H1 and H2 histamine receptors respectively, distinctly diminished excitatory histamine effects. Prostaglandin E2 (10-30 micrograms/kg) enhanced the afferent impulse activity. The results suggest that afferents of the small intestine may be involved in reception of inflammatory and immune responses.
Akoev
G N
GN
Laboratory of Physiology of Sensory Receptors, I. P. Pavlov Institute of Physiology, Academy of Sciences of Russia, St-Petersburg, Russia.
Filippova
L V
LV
Sherman
N O
NO
D000818:Animals; D002415:Cats; D002927:Cimetidine / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007421:Intestine, Small / Q000166:cytology / Q000294:innervation*; D008407:Mast Cells / Q000502:physiology*; D008643:Mesentery / Q000502:physiology; D009475:Neurons, Afferent / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D012702:Serotonin Antagonists; D012701:Serotonin; D002927:Cimetidine; D006632:Histamine; D015232:Dinoprostone