Cellular immune mechanisms in myosin-induced myocarditis.
Cardiac myosin-induced myocarditis proved to be a valuable virus-free murine model with which to investigate autoimmunological mechanisms in inflammatory heart disease. The disease was shown to be T cell-mediated. In this contribution the functional role of CD4 and CD8 molecules and the conditions that are required to make the cardiac tissue susceptible to an autoimmune attack are discussed.
Pummerer
C
C
Department of Pediatrics, Medical School, University of Innsbruck, Austria.
Grässl
G
G
Neu
N
N
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D007111:Immunity, Cellular / Q000276:immunology*; D007124:Immunoenzyme Techniques; D016219:Immunotherapy, Adoptive; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D009205:Myocarditis / Q000276:immunology* / Q000473:pathology; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D009218:Myosins / Q000276:immunology*
D001323:Autoantibodies; D008070:Lipopolysaccharides; D009218:Myosins