title: A factor analytic study of symptoms in acute schizophrenia.
abstract: The three-syndrome model of schizophrenic phenomenology has been well established in chronic illness. We report an attempt to replicate this concept in a sample of acutely unwell schizophrenic patients. Factor analysis was performed using PSE data collected within a week of admission from 114 patients who met DSMIII(R) diagnostic criteria for schizophrenia. Four main factors accounted for 58% of the variance. The first two factors closely resembled Liddle's disorganisation and psychomotor poverty syndromes. Hallucinations and delusions loaded separately under the third and fourth factors. To examine the validity of these four syndromes, the relationships between factor scores and other clinical data were examined. The disorganisation syndrome was associated with a history of multiple past admissions and a longer lifetime duration of in-patient treatment.
authors.affiliation: Section of Neuropsychiatry, Institute of Psychiatry, London.
authors.forename: J D
authors.initials: JD
authors.lastname: Mellers
authors.forename: P
authors.initials: P
authors.lastname: Sham
authors.forename: P B
authors.initials: PB
authors.lastname: Jones
authors.forename: B K
authors.initials: BK
authors.lastname: Toone
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D003702:Delusions / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006212:Hallucinations / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis*; D012562:Schizophrenia, Disorganized / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D012564:Schizophrenic Language; D012565:Schizophrenic Psychology; D013577:Syndrome; D014705:Verbal Behavior