Breast cancer 99mTc SM3 radioimmunoscintigraphy.
99mTc SM3 radioimmunoscintigraphy is combined with kinetic analysis and probability mapping using a change detection algorithm to investigate axillary node involvement before primary surgery in patients with breast cancer. Whereas planar imaging was unsuccessful, axillary node involvement was correctly determined in 11 out of 13 patients 6 out of 7 true negatives and 5 out of 6 true positives down to 0.35 grams. A prospective study is underway.
Granowska
M
M
St. Bartholomew's Hospital and Medical College Imperial Cancer Research Fund, ICRF, Nuclear Medicine Group, London, UK.
Biassoni
L
L
Carroll
M J
MJ
Howell
R
R
Mather
S J
SJ
Ellison
D
D
Granowski
A
A
Britton
K E
KE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008207:Lymphatic Metastasis; D018396:Mucin-1 / Q000276:immunology; D016719:Radioimmunodetection; D012680:Sensitivity and Specificity; D013667:Technetium
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D007074:Immunoglobulin G; D018396:Mucin-1; D013667:Technetium