title: [Random biopsy and recurrence risk in patients with bladder cancer].
abstract: BACKGROUND
  We studied the relationship between the recurrence rate of primary superficial bladder cancer and random biopsy.
  
  
  METHODS
  We performed transurethral resection of primary superficial bladder cancer in 144 patients, and in 55 of those cases a random biopsy was also performed. The non-recurrence rate was examined in many recurrence facters.
  
  
  RESULTS
  The non-recurrence rate in the group with random biopsy was not significantly different from that observed in the group (100 patients) without random biopsy (chi 2 test, Generalized Wilcoxon test and multivariate analysis). Because the intravesical instillation therapy is an important inhibition factor in the recurrence rate of the primary superficial bladder cancer, we further analysed the recurrence rate in two non treated groups with or without random biopsy (13 and 35 patients respectively). No significant difference in the rate of recurrence between the two groups was observed. However, we noted recurrence of bladder cancer at biopsy positions in 8/13 patients.
  
  
  CONCLUSIONS
  It appears that random biopsy may have an effect on the recurrence or the implantation of tumor cells. Further studies are needed to clarify whether random biopsy is a risk factor in the recurrence rate of primary superficial bladder cancer.
authors.affiliation: Department of Urology, Nagoya City University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Kohri
authors.forename: E
authors.initials: E
authors.lastname: Terao
authors.forename: N
authors.initials: N
authors.lastname: Hirao
authors.lastname: HoriH
authors.lastname: IwaiY
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Tawada
authors.forename: H
authors.initials: H
authors.lastname: Asaka
authors.forename: H
authors.initials: H
authors.lastname: Andou
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: T
authors.initials: T
authors.lastname: Ikeuchi
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D001706:Biopsy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011468:Prostatectomy; D012189:Retrospective Studies; D012306:Risk; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery