title: Interleukin-1 signal transduction.
abstract: Interleukin-1 (IL-1) is primarily an inflammatory cytokine, although it is capable of mediating a wide variety of effects on many different cell types. Nearly every known signal transduction pathway has been reported to be activated in response to IL-1. However, the significance of many of these signaling events is unclear, due to the use of different and sometimes unique cell lines in studying IL-1-initiated signal transduction. Complicating matters further is the lack of association in many studies between identified IL-1-induced signals and subsequent biological responses. In this article, we review what is known about IL-1 receptor signaling and, whenever possible, correlate signaling events to biological responses.
authors.affiliation: Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Bankers-Fulbright
authors.forename: K R
authors.initials: KR
authors.lastname: Kalli
authors.forename: D J
authors.initials: DJ
authors.lastname: McKean
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology*; D050356:Lipid Metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007375:Interleukin-1; D019204:GTP-Binding Proteins