title: Long-term pulmonary function in children with Hodgkin's disease.
abstract: We studied the long-term pulmonary function of 25 patients who were at least 5 years post-treatment for Hodgkin's disease. The mean age of the patients was 17 years (range 9.5-25 years) at the time of study. Twenty-one of the patients were male. All patients received six courses of COPP chemotherapy and, in addition, 8 of the 25 patients received radiotherapy to the mediastinum in low or moderate doses (20-30 Gy). One patient had symptoms of bronchiectasia. The chest radiographs of nine patients (36%) showed minimal abnormalities. We divided patients into two groups while evaluating their pulmonary function tests according to whether they received mantle irradiation or not. In patients who received mantle irradiation, pulmonary function tests showed a minimal decrease in FEV1. The decrease in FEV1 indicated an obstructive ventilatory defect. We concluded that our treatment protocols for paediatric Hodgkin's disease were curative, well tolerable and might minimize pulmonary functional changes.
authors.affiliation: Department of Pediatric Oncology, Hacettepe University, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Ilhan
authors.forename: F
authors.initials: F
authors.lastname: Sarialioğlu
authors.forename: H
authors.initials: H
authors.lastname: Bilgiç
authors.forename: A
authors.initials: A
authors.lastname: Göçmen
authors.forename: M
authors.initials: M
authors.lastname: Büyükpamukcu
authors.forename: C
authors.initials: C
authors.lastname: Akyüz
authors.forename: T
authors.initials: T
authors.lastname: Kutluk
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone