Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi.
A diterpenoid, totarol (1), from Podocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone isolated from the same source, had no antioxidative activity. Furthermore, totarol protected red cells against oxidative hemolysis. This diterpene was shown to be effective in protecting biological systems against oxidative stresses.
Haraguchi
H
H
Faculty of Engineering, Fukuyama University, Japan.
Ishikawa
H
H
Sakai
S
S
Ying
B P
BP
Kubo
I
I
D045784:Abietanes; D000244:Adenosine Diphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009243:NAD / Q000378:metabolism / Q000494:pharmacology; D009249:NADP / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
D045784:Abietanes; D000975:Antioxidants; D004224:Diterpenes; D008041:Linoleic Acids; D008563:Membrane Lipids; C029936:adenosine diphosphate-ferric chelate; D009243:NAD; D009249:NADP; D000244:Adenosine Diphosphate; C078548:totarol; D019787:Linoleic Acid