title: Complete hydatidiform mole with a coexistent embryo.
abstract: We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound study revealed no evidence of an embryo, and a pattern consistent with a hydatidiform mole. Dilation and curettage was subsequently performed that showed a classic hydatidiform mole on histological examination. Chromosome analysis revealed a normal 46,XX karyotype. DNA was extracted from the placental tissue, as well as maternal and paternal blood. Molecular genetic analysis was; performed with four variable number of tandem repeats (VNTR) probes and showed the placental tissue to consist of only paternal DNA with two genomic copies of each allele studied. These findings are consistent with the diagnosis of complete hydatidiform mole and its origin from an empty ovum fertilized by a single sperm. This is the first reported case of a living embryo coexistent with a complete hydatidiform mole documented by genetic analysis.
authors.affiliation: Department of Pathology, UCSD School of Medicine, San Diego, CA 92103-8720, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Baergen
authors.forename: T
authors.initials: T
authors.lastname: Kelly
authors.forename: M J
authors.initials: MJ
authors.lastname: McGinniss
authors.forename: O W
authors.initials: OW
authors.lastname: Jones
authors.forename: K
authors.initials: K
authors.lastname: Benirschke
mesh_terms: D000328:Adult; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D007621:Karyotyping; D008297:Male; D015335:Molecular Probes; D010334:Paternity; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*
chemical_list: D015335:Molecular Probes; D004247:DNA