Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes?
The genetic toxicity of non-steroidal anti-inflammatory drugs was investigated using the sister chromatid exchange technique in cultured human lymphocytes. A total of 48 patients were treated with non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac or acetylsalicylic acid) for 2 weeks. The average numbers of sister chromatid exchanges in cultured lymphocytes from the patients, before and after treatment with these drugs, did not differ significantly (P > 0.05). These results indicate that treatment with non-steroidal anti-inflammatory drugs for 2 weeks does not induce sister chromatid exchanges in T lymphocytes.
Ozkul
Y
Y
Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Erenmemisoglu
A
A
Ekecik
A
A
Saatci
C
C
Ozdamar
S
S
Demirtas
H
H
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D004008:Diclofenac / Q000009:adverse effects; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D007660:Ketoprofen / Q000009:adverse effects; D008297:Male; D009288:Naproxen / Q000009:adverse effects; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D009288:Naproxen; D007660:Ketoprofen; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin