title: Model-based scatter correction for fully 3D PET.
abstract: A method is presented that directly calculates the mean number of scattered coincidences in data acquired with fully 3D positron emission tomography (PET). This method uses a transmission scan, an emission scan, the physics of Compton scatter, and a mathematical model of the scanner in a forward calculation of the number of events for which one photon has undergone a single Compton interaction. The distribution of events for which multiple Compton interactions have occurred is modelled as a linear transformation of the single-scatter distribution. Computational efficiency is achieved by sampling at rates no higher than those required by the scatter distribution and by implementing the algorithm using look-up tables. Evaluation studies in phantoms with large scatter fractions show that the method yields images with quantitative accuracy equivalent to that of slice-collimated PET in clinically useful times.
authors.affiliation: Washington University, Neuro-Imaging Laboratory, St Louis, MO 63110, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Ollinger
mesh_terms: D000465:Algorithms; D006801:Humans; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods