Development and implementation of cost-effective guidelines in the laboratory investigation of diarrhea in a community hospital.
BACKGROUND
Fecal cultures are often inappropriately requested in the investigation of diarrhea.


OBJECTIVE
To develop and determine the efficacy of practice guidelines for the ordering and processing of stool cultures that are submitted for the diagnosis of community-acquired diarrhea.


METHODS
The results of stool cultures that were submitted to the microbiology laboratory of a tertiary care nonteaching community hospital were retrospectively reviewed. Following the implementation of guidelines, the efficacy was evaluated by comparison of fecal culture results in a prospective manner.


RESULTS
Analysis of results of stool cultures that were obtained from 3072 patients during a 3-year period revealed that (1) the sensitivity (40%) and predictive value (20%) of finding neutrophils in smear preparations were too low to be clinically useful, (2) routine cultures from patients with nosocomial diarrhea were uniformly negative, and (3) multiple specimens from a patient rarely provided additional information. Based on these findings, new guidelines were developed and implemented with the cooperation of clinical staff. Three-month follow-up results showed that the total number of specimens, the number of specimens from patients with nosocomial diarrhea, and multiple specimens declined by 37.7%, 70.6%, and 50%, respectively. However, the isolation rate of pathogens increased from 11.7% to 18.7%.


CONCLUSIONS
The application of practice guidelines that include elimination of smear examination of rectal swabs, exclusion of routine cultures from patients with nosocomial diarrhea, and rejection of repeated cultures can result in significant cost saving without adversely affecting patient care.
Chitkara
Y K
YK
Department of Laboratory Medicine, Carondelet St Mary's Hospital, Tucson, AZ, USA.
McCasland
K A
KA
Kenefic
L
L
D001130:Arizona; D019411:Clinical Laboratory Techniques / Q000191:economics*; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000191:economics / Q000382:microbiology; D003362:Cost-Benefit Analysis; D003428:Cross Infection / Q000175:diagnosis / Q000191:economics / Q000382:microbiology; D003967:Diarrhea / Q000175:diagnosis* / Q000191:economics* / Q000382:microbiology; D005069:Evaluation Studies as Topic; D005243:Feces / Q000382:microbiology*; D006745:Hospital Bed Capacity, 300 to 499; D006764:Hospitals, Community / Q000191:economics; D006801:Humans; D007755:Laboratories, Hospital / Q000191:economics* / Q000592:standards; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity