Immunogenicity of the whole antigen and glycoprotein I of varicella-zoster virus (VZV) and the VZV skin test antigen.
Specific cellular immunity against the whole antigen and glycoprotein I (gp I) of varicella-zoster virus (VZV) and the skin test antigen were determined for 13 healthy immune adults to compare the immunogenicity of these antigens using a lymphoproliferative assay. The stimulation index values (mean +/- s.d.) were 16.4 +/- 11.2 against the whole VZV antigen, 4.2 +/- 2.9 against the VZV skin test antigen and 1.1 +/- 0.5 against gp I. The immunogenicity of the skin test antigen, which mainly contains gp III and gp IV, appears to be more favorable than that of gp I alone, but to be weaker than that of the whole VZV antigen.
Kawano
S
S
Department of Pediatrics, Kawasaki Medical School, Okayama, Japan.
Terada
K
K
Hiraga
Y
Y
Morita
T
T
D000328:Adult; D000956:Antigens, Viral / Q000276:immunology*; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D012882:Skin Tests; D014759:Viral Envelope Proteins / Q000276:immunology*
D000956:Antigens, Viral; D014759:Viral Envelope Proteins; C056913:glycoprotein E, varicella-zoster virus