Lectin-activated CD4+CD45RA+ T-lymphocytes have no ability to kill monocytes.
Monocytes are eliminated from cell culture by antigen or mitogen activated cytotoxic CD4+ T-lymphocytes. In this report we asked the question whether CD4+CD45RA+ and CD4+CD45RO+ subpopulations differ in the ability to kill monocytes in pokeweed mitogen (PWM)-activated cultures. Data are presented that although CD4+CD45RA+ vigorously proliferate in the presence of PWM, they do not kill monocytes or secrete IFN gamma.
Pryjma
J
J
Department of Clinical Immunology and Microbiology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland.
Baran
J
J
Zembala
M
M
D000938:Antigen-Presenting Cells / Q000276:immunology*; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D002455:Cell Division; D002478:Cells, Cultured; D018920:Coculture Techniques; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D017493:Leukocyte Common Antigens / Q000032:analysis*; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
D011043:Pokeweed Mitogens; D007371:Interferon-gamma; D017493:Leukocyte Common Antigens