[A study of the relation between clinical prognostic factors and the estimated tumor growth speed in superficial bladder cancer].
(BACKGROUND). We studied the dynamic estimation of biological activity to evaluate stage progression using clinical findings of the superficial bladder cancer. (METHODS). From 1983 to 1993, 111 patients who underwent transurethral resection initially. 54 (48.6%) cases showed tumor recurrences at least once were estimated the tumor growth speed, dividing the total amount of tumor volume of summing all tumors at a certain recurrence with the duration between recurrences, and which was compared with various prognostic factors of the superficial bladder cancer. The Prognostic factors included age, sex, frequency of recurrences, tumor's number, tumor's size, stage, histological grade, shape, intravesical treatment and duration to recurrence from the last transurethral resection. (RESULTS). Seven (13%) cases showed disease progression in the sense of tumor stage (T2 < ) out of 54 recurrent patients. The tumor growth speed during one episode of recurrence was not statistical different between any factors. However, the average of tumor growth speed, which was calculated based on all episodes of recurrences, was statistically different (the cases with stage progression versus without : P < 0.05) between the cases with and without stage progression. (CONCLUSION). The results suggested that the dynamic estimation of biological activity of the superficial bladder cancer has a potential to be an important prognostic factor to determine the stage progression of the disease.
Ota
T
T
Department of Urology, University of Tsukuba, Japan.
Akaza
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000473:pathology*