Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.
OBJECTIVE
The authors' goal was to determine whether either of two 5-HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response.


METHODS
Brief Psychiatric Rating Scale (BPRS) ratings were obtained in 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis.


RESULTS
Neither 102-T/C nor 452-His/Tyr was associated with clozapine response. There were no significant differences in BPRS scores among patients with different 5-HT2A genotypes at week 10 of clozapine administration.


CONCLUSIONS
Allelic variation in the 5-HT2A gene is not associated with individual differences in clozapine response.
Malhotra
A K
AK
Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892-13880, USA.
Goldman
D
D
Ozaki
N
N
Breier
A
A
Buchanan
R
R
Pickar
D
D
D000328:Adult; D000483:Alleles; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D003024:Clozapine