[The phenotypic characteristics of healthy carriers of the antigenic structures of the influenza A virus].
Highly sensitive methods for the detection of viral antigens with the use of monoclonal or polyclonal enzyme immunoassay test systems, as well as virus-specific nucleic sequences (NS-gene) in polymerase chain reaction, made it possible to establish the fact of long-term asymptomatic virus carriership (AVC) in some of adolescent schoolchildren in a closed group. The occurrence of AVC varied at different phases of the epidemic process. The tendency to AVC was observed in individuals having blood group B (III) and HLA-A9 antigen of the major histocompatibility complex. The development of AVC occurred in the presence of a decreased level of humoral immunity. AVC was mainly registered among individuals, relatively resistant to relapsing clinically pronounced forms of respiratory virus infections.
Tsybalova
L M
LM
Sominina
A A
AA
Popova
T L
TL
Filippova
I E
IE
Zibina
E A
EA
Bekhtereva
T A
TA
Konovalova
I I
II
Voĭtsekhovskaia
E M
EM
Semilutskaia
I B
IB
D000293:Adolescent; D000704:Analysis of Variance; D000956:Antigens, Viral / Q000032:analysis*; D002353:Carrier State / Q000276:immunology* / Q000821:virology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007113:Immunity, Innate; D007124:Immunoenzyme Techniques; D009980:Influenza A virus / Q000276:immunology* / Q000302:isolation & purification; D007251:Influenza, Human / Q000235:genetics / Q000276:immunology* / Q000821:virology; D009305:Nasopharynx / Q000821:virology; D010641:Phenotype; D016133:Polymerase Chain Reaction
D000956:Antigens, Viral
Fenotipicheskie osobennosti zdorovykh nositeleĭ antigennykh struktur virusa grippa A.