Extra Y chromosome in T-cell acute lymphoblastic leukemia.
We describe a 66-year-old man who developed T-cell acute lymphoblastic leukemia (ALL) with a sole clonal chromosomal abnormality of 47,XY,+Y. Leukemic cells were positive for CD2, CD7, terminal deoxynucleotidyl transferase and cytoplasmic CD3. T-cell receptor beta, gamma, and delta genes remained germline configurations. The bone marrow aspirate was 47,XY,+Y in all metaphase cells observed. The patient achieved complete remission by chemotherapy, and the bone marrow cells and the phytohemagglutinin stimulated peripheral blood lymphocytes showed a normal karyotype of 46,XY at that time. This fact suggests that an extra Y chromosome may be a kind of new chromosomal abnormality of T-cell ALL.
Watanabe
A
A
Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
Kawachi
Y
Y
Nishihara
T
T
Uchida
T
T
Setsu
K
K
Hikiji
K
K
D000368:Aged; D002869:Chromosome Aberrations; D016762:Genes, fos; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D014998:Y Chromosome