title: Grading and therapy monitoring of astrocytomas with 1H-spectroscopy: preliminary study.
abstract: We examined 11 patients (9 male and 2 female, age 41 +/- 13) presenting astrocytomas of different malignancy grade (WHO) with single voxel (PRESS) and double voxel (STABLE) spectroscopy techniques. The content of choline in the tumors was determined as a function of their grade of malignity and a significant correlation was found. The measurements were repeated after interstitial radiosurgery. Observed spectra changes induced by this stereotactic treatment with 125I-seed demonstrated the possibility of therapy monitoring.
authors.affiliation: Department of Radiology, University of Freiburg, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Speck
authors.forename: T
authors.initials: T
authors.lastname: Thiel
authors.forename: J
authors.initials: J
authors.lastname: Hennig
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001254:Astrocytoma / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D002794:Choline / Q000032:analysis; D005260:Female; D006801:Humans; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
chemical_list: D007773:Lactates; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D002794:Choline