title: A comparison of mivacurium dosage requirements during isoflurane and desflurane anesthesia.
abstract: OBJECTIVE
  To evaluate the dose requirement and recovery characteristics of mivacurium infusions during anesthesia with equipotent concentrations of either desflurane or isoflurane.
  
  
  METHODS
  Randomized, open-study comparing the effects of desflurane and isoflurane on mivacurium-induced neuromuscular blockade.
  
  
  METHODS
  Operating suite of a university-affiliated medical center.
  
  
  METHODS
  41 ASA status I, II, and III adult patients, requiring more than 45 minutes of neuromuscular blockade for surgery.
  
  
  METHODS
  Following a standardized induction sequence and established steady desflurane-nitrous oxide (DES group) or isoflurane-nitrous oxide (ISO group) anesthesia at 1 minimum alveolar concentration (MAC), an intubating dose of 0.2 mg/kg of mivacurium chloride was administered. Ventilation was maintained with a face mask until the first twitch (T1) of the evoked train-of-four (TOF) reached 10% or less of control when tracheal intubation was performed. T1 was allowed to return to 10% of its control value. An infusion of mivacurium at the initial rate of 5 micrograms/kg/min was then started and adjusted to maintain T1 at 10% +/- 2% of control. Within 20 minutes of completion of surgery, the mivacurium infusion was stopped, and the time for the evoked electromyograph (EMG) to return to 25% and 75% of the original baseline was noted.
  
  
  RESULTS
  Neuromuscular function was monitored continuously by an evoked EMG. The average infusion rate was 5.7 +/- 2.4 micrograms/kg/min (mean +/- SD) for DES group (n = 20) and 6.6 +/- 2.7 micrograms/kg/min for ISO group (n = 21) (p = NS). There was no change in the infusion rate of mivacurium over time for both groups. However, there was an inverse relationship in both groups between the time to recovery following a bolus dose and the subsequent mean infusion rate of mivacurium (correlation coefficient = -5.0; p < 0.005). The spontaneous recovery index (T25-75) for the two groups was identical, 11.5 +/- 4.9 min (mean +/- SD) for DES group and 11.5 +/- 7.9 min for ISO group (p = NS).
  
  
  CONCLUSIONS
  There were no differences in the dose requirement and recovery indices of mivacurium during either desflurane or isoflurane-based anesthesia. Patients who took longer to recover from the bolus dose in both groups showed a subsequent reduction in dose requirements of mivacurium.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Gan
authors.forename: T J
authors.initials: TJ
authors.lastname: Quill
authors.forename: C
authors.initials: C
authors.lastname: Pressley
authors.forename: S
authors.initials: S
authors.lastname: Parrillo
authors.forename: P S
authors.initials: PS
authors.lastname: Glass
mesh_terms: D000328:Adult; D000758:Anesthesia; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation; D000077335:Desflurane; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D007530:Isoflurane / Q000031:analogs & derivatives*; D007546:Isoquinolines / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D000077590:Mivacurium; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage
chemical_list: D018685:Anesthetics, Inhalation; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D000077335:Desflurane; D007530:Isoflurane