title: Biochemical markers of bone metabolism during distance running in healthy, regularly exercising men and women.
abstract: The purpose of the present study was to evaluate the effects of long distance running on bone metabolism, using the biochemical markers ICTP (the carboxyterminal cross-linked telopeptide of type I collagen), PICP (the carboxyterminal propeptide of type I procollagen), osteocalcin and bALP (bone specific alkaline phosphatase) as well as parathyroid hormone (PTH) and serum calcium. Twenty healthy, regularly exercising individuals, 10 women and 10 men, participated in a running competition. The mean age was 38 (range 22-55) and 39 (range 22-53) years respectively, the performed distance 15 (range 5-30) and 28 (range 15-30) km respectively, with a speed of 5:30, 5:02 per kilometer respectively. Fasting blood samples were drawn in the morning the day before the race, and also the day after and two days after. A decrease of PICP concentrations among women was evident the day after the competition (from 170 +/- 17 micrograms/l to 158 +/- 17 micrograms/l) which returned to pre-exercise levels two days after the race (167 +/- 19 micrograms/l). Furthermore, a decrease of osteocalcin could be seen in the men one day after the exercise (from 12.1 +/- 1.1 micrograms/l to 10.3 +/- 1.1 micrograms/l). In the men, there was also an increase of ICTP concentrations two days after (3.98 +/- 0.35 micrograms/l) this long-term and demanding exercise, when compared with pre-exercise levels (3.67 +/- 0.28). One single bout of long-term, exhaustive running exercise in well-trained men and women seems to induce a temporary inhibition of bone formation as well as a stimulation of bone resorption.
authors.affiliation: Department of Internal Medicine, University Hospital, Uppsala, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Brahm
authors.forename: K
authors.initials: K
authors.lastname: Piehl-Aulin
authors.forename: S
authors.initials: S
authors.lastname: Ljunghall
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000097:blood; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010807:Physical Endurance / Q000502:physiology*; D011347:Procollagen / Q000097:blood; D012420:Running / Q000502:physiology*
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011347:Procollagen; D015675:Osteocalcin; D003094:Collagen