title: Does brief dynamic psychotherapy reduce the relapse rate of panic disorder?
abstract: BACKGROUND
  Although panic disorder can be effectively alleviated by drug treatment, the relapse rate is high. By adding brief dynamic psychotherapy focused on the psychosocial vulnerability of patients with panic disorder to an established drug treatment regimen, we hypothesized that this would result in a lower relapse rate after pharmacotherapy.
  
  
  METHODS
  Patients with panic disorder (defined by DSM-III-R) were randomized to treatment with either clomipramine for 9 months (n = 20), or clomipramine for 9 months combined with 15 weekly sessions of brief dynamic psychotherapy (n = 20). Measures of anxiety and depression were collected at intake and at regular intervals. The patients had blind follow-up interviews at 6, 12, and 18 months after beginning treatment.
  
  
  RESULTS
  All patients in both groups became free of panic attacks within 26 weeks of the start of treatment. On termination of pharmacotherapy, the relapse rate was significantly higher in the clomipramine-only group during the follow-up period. There were significantly lower scores for most anxiety measures in the clomipramine plus psychotherapy group at the 9-month follow-up.
  
  
  CONCLUSIONS
  The addition of brief dynamic psychotherapy to treatment with clomipramine significantly reduces the relapse rate of panic disorder compared with clomipramine treatment alone.
authors.affiliation: Research Unit, Aker Hospital, Division of Psychiatry, University of Oslo, Norway.
authors.forename: I M
authors.initials: IM
authors.lastname: Wiborg
authors.forename: A A
authors.initials: AA
authors.lastname: Dahl
mesh_terms: D002997:Clomipramine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D016584:Panic Disorder / Q000188:drug therapy / Q000517:prevention & control* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011614:Psychotherapy, Brief; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D002997:Clomipramine