title: A receptor in pituitary and hypothalamus that functions in growth hormone release.
abstract: Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.
authors.affiliation: Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Howard
authors.forename: S D
authors.initials: SD
authors.lastname: Feighner
authors.forename: D F
authors.initials: DF
authors.lastname: Cully
authors.forename: J P
authors.initials: JP
authors.lastname: Arena
authors.forename: P A
authors.initials: PA
authors.lastname: Liberator
authors.forename: C I
authors.initials: CI
authors.lastname: Rosenblum
authors.forename: M
authors.initials: M
authors.lastname: Hamelin
authors.forename: D L
authors.initials: DL
authors.lastname: Hreniuk
authors.forename: O C
authors.initials: OC
authors.lastname: Palyha
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: P S
authors.initials: PS
authors.lastname: Paress
authors.forename: C
authors.initials: C
authors.lastname: Diaz
authors.forename: M
authors.initials: M
authors.lastname: Chou
authors.forename: K K
authors.initials: KK
authors.lastname: Liu
authors.forename: K K
authors.initials: KK
authors.lastname: McKee
authors.forename: S S
authors.initials: SS
authors.lastname: Pong
authors.forename: L Y
authors.initials: LY
authors.lastname: Chaung
authors.forename: A
authors.initials: A
authors.lastname: Elbrecht
authors.forename: M
authors.initials: M
authors.lastname: Dashkevicz
authors.forename: R
authors.initials: R
authors.lastname: Heavens
authors.forename: M
authors.initials: M
authors.lastname: Rigby
authors.forename: D J
authors.initials: DJ
authors.lastname: Sirinathsinghji
authors.forename: D C
authors.initials: DC
authors.lastname: Dean
authors.forename: D G
authors.initials: DG
authors.lastname: Melillo
authors.forename: A A
authors.initials: AA
authors.lastname: Patchett
authors.forename: R
authors.initials: R
authors.lastname: Nargund
authors.forename: P R
authors.initials: PR
authors.lastname: Griffin
authors.forename: J A
authors.initials: JA
authors.lastname: DeMartino
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: J M
authors.initials: JM
authors.lastname: Schaeffer
authors.forename: R G
authors.initials: RG
authors.lastname: Smith
authors.forename: L H
authors.initials: LH
authors.lastname: Van der Ploeg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003062:Codon; D018076:DNA, Complementary / Q000235:genetics; D019204:GTP-Binding Proteins / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007033:Hypothalamus, Middle / Q000737:chemistry; D007211:Indoles / Q000378:metabolism* / Q000494:pharmacology; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism*; D010902:Pituitary Gland / Q000737:chemistry; D018075:RNA, Complementary / Q000235:genetics; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D013141:Spiro Compounds / Q000378:metabolism* / Q000494:pharmacology; D013552:Swine
chemical_list: D003062:Codon; D018076:DNA, Complementary; D006728:Hormones; D007211:Indoles; D009842:Oligopeptides; D018075:RNA, Complementary; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D013141:Spiro Compounds; C041048:growth hormone releasing hexapeptide; D013006:Growth Hormone; D019204:GTP-Binding Proteins; C094817:ibutamoren mesylate