title: [The role of free radicals in pathogenesis of insulin dependent diabetes mellitus].
abstract: The role of free radicals as well as cytokines (IL-1, tumor necrosis factor alpha, interferon gamma) and nitric oxide in the immune-mediated processes leading to the beta-cell destruction during IDDM is described. It is also pointed that the excess of IL-1ra in relation to IL-1 prevents IL-1 toxicity to beta-cells.
authors.affiliation: Katedra i Zakład Chemii Klinicznej i Diagnostyki Laboratoryjnej Slaskiej Akademii Medycznej w Sosnowcu.
authors.forename: K
authors.initials: K
authors.lastname: Komosińska
authors.forename: K
authors.initials: K
authors.lastname: Olczyk
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D016207:Cytokines / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005609:Free Radicals / Q000276:immunology*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D009569:Nitric Oxide / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016207:Cytokines; D005609:Free Radicals; D017382:Reactive Oxygen Species; D009569:Nitric Oxide
vernacular_title: Rola wolnych rodników w patogenezie cukrzycy insulinozaleznej.