title: In vitro activity of MDL 62,879 against gram-positive bacteria and Bacteroides species.
abstract: The new thiazolyl peptide antibiotic MDL 62,879 (GE2270 A) showed excellent in vitro activity in testing against staphylococci and streptococci, with MIC90s ranging from 0.23 to 0.9 mg/l. It was very active against Clostridium difficile and Propionibacterium acnes (MIC90 0.06 mg/l in each case) and had variable activity against Bacteroides spp. MDL 62,879 had exceptionally good activity against Enterococcus faecalis, including against a collection of high-level aminoglycoside-resistant isolates where it had an MIC90 of 0.047. The antibiotic was bacteriostatic for enterococcal isolates but bactericidal for a methicillin-resistant isolate of Staphylococcus aureus.
authors.affiliation: Clinica di Malattie Infettive, Università di Firenze, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bartoloni
authors.forename: A
authors.initials: A
authors.lastname: Mantella
authors.forename: B P
authors.initials: BP
authors.lastname: Goldstein
authors.forename: M
authors.initials: M
authors.lastname: Denaro
authors.forename: P
authors.initials: P
authors.lastname: Nicoletti
authors.forename: F
authors.initials: F
authors.lastname: Paradisi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001439:Bacteroides / Q000187:drug effects*; D002981:Clindamycin / Q000494:pharmacology; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D010456:Peptides, Cyclic; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D010406:Penicillins; D010456:Peptides, Cyclic; D013844:Thiazoles; D002981:Clindamycin; C068122:GE 2270 A