title: Outcome of idiopathic membranoproliferative glomerulonephritis in children. Arbeitsgemeinschaft Pädiatrische Nephrologie.
abstract: The aim of this multicentre study was to analyse the long-term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2-14 years at the onset of the study were followed over 2-20 years; 26 patients had MPGN type I, 17 had type II and 7 had type III. Treatment was variable. At the last observation, 30 patients had reached terminal and four pre-terminal renal failure. The median survival probability until renal death was 15.3, 8.7 and 15.9 years for disease types I, II and III respectively (difference between MPGN types I + III versus type II: p = 0.013). The presence of an initial nephrotic syndrome was associated with a more rapid progression (p = 0.018). C3 nephritic factor was of no prognostic value. We conclude that the outcome of MPGN mainly depends on the histological type observed.
authors.affiliation: Division of Pediatric Nephrology, University Children's Hospital, Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schwertz
authors.forename: R
authors.initials: R
authors.lastname: de Jong
authors.forename: N
authors.initials: N
authors.lastname: Gretz
authors.forename: M
authors.initials: M
authors.lastname: Kirschfink
authors.forename: D
authors.initials: D
authors.lastname: Anders
authors.forename: K
authors.initials: K
authors.lastname: Schärer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003178:Complement C3 Nephritic Factor / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D011379:Prognosis
chemical_list: D003178:Complement C3 Nephritic Factor