title: Decreased sensitivity to the cytogenetic effects of bleomycin in individuals occupationally exposed to ionizing radiation.
abstract: In the present work, 12 individuals occupationally exposed to ionizing radiation and 11 unexposed ones were studied to determine the cytogenetic effect of a challenge dose of bleomycin on their phytohemagglutinin stimulated lymphocytes. After bleomycin treatment, the frequencies of chromatid breaks and gaps were significantly lower in the exposed population (p < 0.025 for both types of chromatid alterations). These results could indicate that occupational exposure to ionizing radiation can induce an adaptive response that can be detected by a subsequent treatment with bleomycin.
authors.affiliation: Dpt. Biologia Animal, Biologia Vegetal i Ecologia, Facultat de Ciències, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Barquinero
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.forename: M R
authors.initials: MR
authors.lastname: Caballín
authors.forename: R
authors.initials: R
authors.lastname: Miró
authors.forename: M
authors.initials: M
authors.lastname: Ribas
authors.forename: A
authors.initials: A
authors.lastname: Subias
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001761:Bleomycin / Q000633:toxicity*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure
chemical_list: D000900:Anti-Bacterial Agents; D001761:Bleomycin