Genetics of autoimmune disease.
In the past year, the major advances in understanding the genetics of autoimmune disease in both man and mouse have been made as a result of using the positional cloning approach. Construction of congenic mouse strains, and, in humans, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.
Merriman
T R
TR
University of Oxford, UK.
Todd
J A
JA
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D004195:Disease Models, Animal; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D011971:Receptors, Immunologic / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid
D011971:Receptors, Immunologic