title: Induction of anaesthesia with midazolam and a target-controlled propofol infusion.
abstract: Eighty patients premedicated with temazepam were allocated randomly to receive an intravenous bolus of midazolam (either 0, 1, 2 or 4 mg) 4 min before a propofol infusion using a system designed to maintain a target blood concentration of 3 micrograms.ml-1. Anaesthesia was successfully induced within 3 min of starting the infusion in 45% of patients receiving no midazolam. This rose to 70%, 85% and 95% in the groups receiving 1, 2 and 4 mg midazolam boluses respectively (p < 0.005). There were reductions in arterial blood pressure 3 min after starting the infusion in all groups but there was no significant difference between the groups. Apnoea was rare. Small doses of midazolam usefully enhance the effect of a propofol infusion administered at a dose which by itself would not induce anaesthesia in a majority of patients.
authors.affiliation: Department of Anaesthesia, Victoria Infirmary, Glasgow.
authors.forename: Y
authors.initials: Y
authors.lastname: Tzabar
authors.forename: C
authors.initials: C
authors.lastname: Brydon
authors.forename: G W
authors.initials: GW
authors.lastname: Gillies
mesh_terms: D000759:Adjuvants, Anesthesia; D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D015742:Propofol
chemical_list: D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D008874:Midazolam; D010100:Oxygen; D015742:Propofol