title: Stability of flucytosine in an extemporaneously compounded oral liquid.
abstract: The stability of flucytosine in an oral liquid prepared from capsules was studied. Flucytosine 10-mg/ml oral liquid was prepared from 500-mg capsules (with distilled water as the diluent) and transferred to 10 glass and 10 plastic amber bottles. Five of each type of bottle were stored at 4 degrees C and five of each at 25 degrees C. Samples were taken at 0, 7, 14, 28, 42, 56, 70, and 91 days, and flucytosine concentration was measured by stability-indicating high-performance liquid chromatography. Flucytosine was stable in the liquid formulation for at least 70 days under all the study conditions. The physical appearance of the liquid stored at 4 degrees C did not change during the study period. Flocculation was observed both in glass and in plastic bottles stored at 25 degrees C on day 14 and thereafter. Flucytosine 10 mg/mL in an extemporaneously prepared oral liquid was stable for 70 days in glass or plastic prescription bottles kept at 4 or 25 degrees C.
authors.affiliation: Children's Medical Center of Northwest Ohio, Toledo 43210, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Wintermeyer
authors.forename: M C
authors.initials: MC
authors.lastname: Nahata
mesh_terms: D000935:Antifungal Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D005437:Flucytosine / Q000032:analysis*; D012996:Solutions; D013696:Temperature; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D012996:Solutions; D005437:Flucytosine