New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.
Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.
Silva
T M
TM
Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, USA.
Schleupner
M A
MA
Tacket
C O
CO
Steiner
T S
TS
Kaper
J B
JB
Edelman
R
R
Guerrant
R
R
D022121:Cholera Vaccines / Q000009:adverse effects*; D003967:Diarrhea / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007781:Lactoferrin / Q000032:analysis; D009504:Neutrophils / Q000502:physiology; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014734:Vibrio cholerae / Q000472:pathogenicity*
D022121:Cholera Vaccines; D014613:Vaccines, Attenuated; D007781:Lactoferrin