Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula.
Seven new sesquiterpenes, majapolenes A [1] and B [2], majapolone [3], and majapols A [4], B [5], C [6], and D [7], were isolated from a Philippine collection of Laurencia majuscula. With the exception of majapolene B [2], all compounds were isolated as inseparable diastereomeric mixtures. Structure elucidation was achieved by spectroscopic methods. Majapolene A [1], a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of Laurencia caraibica.
Erickson
K L
KL
Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Beutler
J A
JA
Gray
G N
GN
Cardellina
J H
JH
Boyd
M R
MR
D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D000461:Rhodophyta / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D012717:Sesquiterpenes; C100474:majapolene A