[The important role of apolipoprotein C-III in lipoprotein metabolism].
Apolipoprotein C-III (apo C-III) is present in the plasma in apo B containing lipoprotein (apo C-III-LpB) and in non apo B containing lipoprotein (apo C-III-Lp non B). Apo C-III inhibits the lipolysis of triglyceride riche particles and the apo B containing lipoprotein binding to the LDL receptor. A clinical study in myocardial infarction survivors (ECTIM study) shows that apo C-III-LpB is a good marker of atherogenesis. Hypolipidemic drugs as fenofibrate and Maxepa decrease the apo C-III-LpB particles. These studies demonstrate that apo C-III presents an important role in apo B containing lipoprotein particles metabolism and atherogenesis. Furthermore apo C-III levels may be reduced by hypolipidemic drugs.
Fruchart
J C
JC
SERLIA et INSERM U325, Institut Pasteur, Lille, France.
Duriez
P
P
D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism; D001056:Apolipoproteins C / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism; D004347:Drug Interactions; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008074:Lipoproteins / Q000378:metabolism*; D011973:Receptors, LDL / Q000378:metabolism
D001055:Apolipoproteins B; D001056:Apolipoproteins C; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011973:Receptors, LDL
Le rôle important de l'apolipoprotéine C-III dans le métabolisme des lipoprotéines.