[The detection and significance of HBV-DNA in serum of pulmonary tuberculous patients].
Hepatitis B virus deoxyribonucleic acid (HBV-DNA) in the serum and the liver function from 268 patients with pulmonary tuberculosis were investigated. The patients have been followed up for 3.5 years. In the course of antituberculous chemotherapy, the abnormal liver function rate turned to be 95% in the positive HBV-DNA group but only 10% and 5.1% in the negatives, HBV-DNA group and pulmonary tuberculosis group respectively (P < 0.01, P < 0.01, P > 0.05). The abnormal liver function rate turned to be 49% in the positive HBV-M group but only 5.1% and 10% in the negative control group and pulmonary tuberculosis group (P < 0.01, P < 0.01, P > 0.05) respectively. The presence of HBV-DNA in patients with pulmonary tuberculosis was associated with high mortality rate and the cause of death was related to hepatic failure. The results suggest that to detect serum HBV-DNA is important in pulmonary tuberculous patients. Antiviral therapy for patients with pulmonary tuberculosis who had detectable HBV-DNA may improve prognosis.
Xu
F
F
Chen
H
H
Yan
B
B
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006508:Hepatitis Antibodies / Q000097:blood; D018963:Hepatitis Antigens / Q000097:blood; D006509:Hepatitis B / Q000188:drug therapy; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000821:virology*
D000995:Antitubercular Agents; D000998:Antiviral Agents; D004279:DNA, Viral; D006508:Hepatitis Antibodies; D018963:Hepatitis Antigens