title: Arthrogryposis multiplex congenita and bilateral parietal polymicrogyria in association with the intrauterine death of a twin.
abstract: A case of neurogenic arthrogryposis multiplex congenita (AMC) with associated neuronal migration abnormalities is described. A child with neurogenic AMC and developmental delay presented with late onset of seizures. The first trimester of the mother's pregnancy was marked by an episode of gastro-enteritis and the intrauterine death of a twin fetus. Computer tomography (CT) and magnetic resonance (MR) imaging demonstrated abnormal neuronal migration consisting of bilateral parietal polymicrogyria, and an isolated grey matter heterotopia.
authors.affiliation: Department of Neuroradiology, Newcastle General Hospital, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Baker
authors.forename: M G
authors.initials: MG
authors.lastname: Khorasgani
authors.forename: D
authors.initials: D
authors.lastname: Gardner-Medwin
authors.forename: A
authors.initials: A
authors.lastname: Gholkar
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
mesh_terms: D017668:Age of Onset; D001176:Arthrogryposis / Q000150:complications* / Q000175:diagnosis; D002465:Cell Movement; D002648:Child; D002828:Choristoma / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005313:Fetal Death; D006801:Humans; D008279:Magnetic Resonance Imaging; D010296:Parietal Lobe / Q000002:abnormalities* / Q000503:physiopathology*; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014427:Twins