title: Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera.
abstract: A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data.
authors.affiliation: Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
authors.forename: F
authors.initials: F
authors.lastname: Fullas
authors.forename: D M
authors.initials: DM
authors.lastname: Brown
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: T E
authors.initials: TE
authors.lastname: Chagwedera
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000085:Acetates; D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; C097940:gummiferol