[Effect of KW-4679, an antiallergic drug, on antigen-induced airway microvascular leakage in rats passively sensitized with mouse monoclonal IgE antibody].
We studied the effect of KW-4679, an antiallergic drug, on inhaled antigen-induced airway microvascular leakage in rats passively sensitized with mouse monoclonal IgE antibody. Inhaled antigen increased extravasation of Evans blue dye content in tracheal and main bronchus tissues. KW-4679 (0.3-10 mg/kg, p.o.) reduced antigen-induced microvascular leakage in trachea with an ED40 value of 4.9 mg/kg. KW-4679 also reduced antigen-induced microvascular leakage in main bronchus with an ED40 value of 0.47 mg/kg. The inhibitory effect of KW-4679 was more potent than those of ketotifen and terfenadine. These results suggest that KW-4679 clearly reduces airway microvascular leakage mediated by antigen-antibody reaction.
Ohmori
K
K
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Ishii
H
H
Sasaki
Y
Y
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D001985:Bronchial Provocation Tests; D002199:Capillary Permeability / Q000187:drug effects*; D003864:Depression, Chemical; D003990:Dibenzoxepins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E / Q000276:immunology*; D007665:Ketotifen / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D000069605:Olopatadine Hydrochloride; D051381:Rats; D011919:Rats, Inbred Strains; D016593:Terfenadine / Q000494:pharmacology; D014132:Trachea / Q000098:blood supply / Q000276:immunology*
D018926:Anti-Allergic Agents; D000911:Antibodies, Monoclonal; D000941:Antigens; D003990:Dibenzoxepins; D000069605:Olopatadine Hydrochloride; D007073:Immunoglobulin E; D016593:Terfenadine; D007665:Ketotifen