title: Mutagenicity of white grape juice in the Ames test.
abstract: The mutagenicity of commercially available white grape juice was evaluated in the Ames mutagenicity test. Grape juice elicited a positive mutagenic, response in Salmonella typhimurium strain TA104 and a weaker response in strains TA97, TA98, TA100 and TA1530. The mutagenic response was evident in the absence of an activation system and inclusion of such a system did not influence mutagenicity. The grape juice-mediated mutagenic response was not due to histidine residues in the juice or likely treatment with sulfite. Moreover, freshly prepared grape juice displayed a similar mutagenic response. Three different brands of commercially available white grape juice were investigated in the Ames test; they all provoked a clear positive mutagenic response, but the degree of mutagenicity differed and could not be attributed to differences in the content of solids. It is concluded that grapes contain direct-acting genotoxic component(s).
authors.affiliation: Molecular Toxicology Group, School of Biological Sciences, University of Surrey, Guildford, UK.
authors.forename: A
authors.initials: A
authors.lastname: Patrineli
authors.forename: M N
authors.initials: MN
authors.lastname: Clifford
authors.forename: R
authors.initials: R
authors.lastname: Walker
authors.forename: C
authors.initials: C
authors.lastname: Ioannides
mesh_terms: D001628:Beverages / Q000032:analysis / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry / Q000633:toxicity*; D006639:Histidine / Q000032:analysis / Q000633:toxicity; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013447:Sulfites / Q000032:analysis / Q000633:toxicity
chemical_list: D009153:Mutagens; D013447:Sulfites; D006639:Histidine