Effects of Chinese herbs on macrophage functions in N-butyl-N-butanolnitrosoamine treated mice.
We investigated the effect of Chinese herbs Lithospermi radix, Astragali radix and Cnidii rhizoma on the functions of macrophages obtained from mice treated with the carcinogen N-butyl-N-butanolnitrosoamine (BBN). The chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with BBN compared with controls. Production of IL-1 and TNF was also markedly reduced. Treatment with Lithospermi radix, Astragali radix, and Cnidii rhizoma significantly inhibited BBN-induced suppression chemotactic activity and production of IL-1 and TNF-alpha by macrophages. Moreover, we found that Astragali radix treated macrophage chemotaxis, it or Cnidii rhizoma induced productions of TNF-alpha were in excess of control.
Jin
R
R
Department of Medical Technology, College of Medical Care and Technology, Gunma University, Japan.
Kurashige
S
S
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000378:metabolism* / Q000494:pharmacology*; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D002085:Butylhydroxybutylnitrosamine