[Suppression of anti-Candida activity of human neutrophils by glucose and diminishment of the glucose effect by an amino acid mixture].
Effects of a glucose and amino acid mixture prescribed for parenteral alimentation on anti-Candida activity of neutrophils were examined. Neutrophils obtained from peripheral blood of healthy humans inhibited the growth of Candida albicans in vitro. More than 1.0% of glucose inhibited the anti-Candida activity of the neutrophils in a dose-dependent manner. This glucose effect was reduced by the addition of an amino acid mixture clinically prescribed with a carbohydrate solution (PN-twin) in Japan. The amino acid mixture neutralized the suppression of anti-Candida activity of neutrophils by dexamethasone. These results suggest that an amino acid mixture prescribed in an alimentation solution may play a role as a neutralizer of the suppressive action of glucose for anti-Candida activity of neutrophils in a limited area near the top of a catheter in a blood vessel.
Tansho
T
T
Second Department of Surgery, Teikyo University School of Medicine, Japan.
Okinaga
K
K
Tansho
S
S
Abe
S
S
Yamaguchi
H
H
D000596:Amino Acids / Q000494:pharmacology*; D002176:Candida albicans / Q000254:growth & development*; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010289:Parenteral Nutrition, Total
D000596:Amino Acids; D005947:Glucose