Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats.
OBJECTIVE
To search for female contraceptive agents.


METHODS
2-Hydroxy-3-methyl-1, 4-naphthoquinone monosemicarbazone (HMNQS) and 2-hydroxy-1, 4-naphthoquinone monothiosemicarbazone (HNQTS) were screened for anti-implantation activity in rats.


RESULTS
Both compounds showed a dose-dependent activity, and HNQTS was more potent. An 100% anti-implantation activity was observed with HNQTS 150 mg kg-1 ig. Its LD50 was found to be > 2 g kg-1 ig in mice.


CONCLUSIONS
HNQTS was more potent than HMNQS for anti-implantation activity in rats.
Dhar
S K
SK
Pharmacology Division, Regional Research Laboratory, Jammu Tawi, India.
Mattu
S
S
D000818:Animals; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology* / Q000633:toxicity; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D009285:Naphthoquinones / Q000494:pharmacology* / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000033:anatomy & histology
D003283:Contraceptives, Postcoital, Synthetic; D009285:Naphthoquinones; C098503:2-hydroxy-3-methyl-1,4-naphthoquinone monosemicarbazone; C098504:2-hydroxy-1,4-naphthoquinone monothiosemicarbazone