Cytology of grade 1 papillary transitional cell carcinoma. A comparison of cytologic, architectural and morphometric criteria in cystoscopically obtained urine.
OBJECTIVE
To assess the diagnostic criteria for grade 1 papillary transitional cell carcinoma (TCC) in cystoscopically obtained urine.


METHODS
We compared the sensitivity, specificity and positive predictive value of cytologic, architectural and morphometric (primarily architectural) criteria in 177 specimens with corresponding biopsy follow-up.


RESULTS
Sensitivities ranged from 22% to 44%, specificities from 69% to 85% and positive predictive values from 59% to 66%.


CONCLUSIONS
The currently described cytologic, architectural and morphometric criteria are inadequate for the identification of grade 1 papillary TCC, and the cytologic diagnosis of grade 1 papillary TCC in cystoscopically obtained urine remains unreliable.
Renshaw
A A
AA
Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Nappi
D
D
Weinberg
D S
DS
D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000652:urine*; D004396:Coloring Agents; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000652:urine*; D014556:Urine / Q000166:cytology*
D004396:Coloring Agents