Differential vasopressin and oxytocin innervation of the human parabrachial nucleus: no changes in Alzheimer's disease.
The distribution of vasopressin and oxytocin immunoreactive fibers was examined in the pontine parabrachial nucleus of the human brain using purified polyclonal antibodies. The results revealed a striking predominance of vasopressin in this brain region. No obvious density difference, either in vasopressin or in oxytocin innervation, was found between Alzheimer's disease patients and matched controls. The present study corroborates other reports that suggest that in Alzheimer's disease the vasopressin innervation in the caudal part of the human brain is not affected.
van Zwieten
E J
EJ
Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, The Netherlands.
Ravid
R
R
Swaab
D F
DF
D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D001921:Brain / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010121:Oxytocin / Q000276:immunology*; D011149:Pons / Q000276:immunology*; D013681:Tegmentum Mesencephali / Q000276:immunology*; D014667:Vasopressins / Q000276:immunology*
D000906:Antibodies; D014667:Vasopressins; D010121:Oxytocin