title: Anaesthetic management of labour and delivery in the parturient with mitochondrial myopathy.
abstract: OBJECTIVE
  We describe the anaesthetic management for Caesarean section in a parturient with a defect in complex III of the respiratory chain who had increased lactate concentrations at rest and with exercise.
  
  
  METHODS
  We administered effective epidural anaesthesia with lidocaine for Caesarean delivery. The serum lactate concentration was less than the preoperative value both during and after surgery. Shivering during the perioperative period was avoided by administering warm i.v. fluids, warm local anaesthetic solution and epidural meperidine. Pain relief after surgery was provided with i.v. PCA morphine augmented by local infiltration with bupivacaine to fascia and skin edges and epidural injection with meperidine.
  
  
  CONCLUSIONS
  Mitochondrial myopathies are an uncommon group of disorders in which mitochondrial dysfunction leads to clinical disease of muscle and sometimes of other organs with high energy requirements. The management of labour and delivery in women with mitochondrial myopathies should be individualized according to severity of disease and formulated by consultation between attending physicians and the anaesthetist. Epidural analgesia reduces stress and work associated with labour and reduces oxygen demand during labour. However, parturients with defects of the respiratory chain with documented increased lactate concentrations at rest and with exercise are best managed with elective Caesarean delivery with regional anaesthesia to prevent life-threatening lactic acidosis during labour. The association between malignant hyperthermia and these disorders has not been proved, but it appears prudent to consider these women as MH susceptible until definitive data regarding this possible relationship are available.
authors.affiliation: Department of Anaesthesia, Ottawa Civic Hospital, Ontario, Canada.
authors.forename: O P
authors.initials: OP
authors.lastname: Rosaeg
authors.forename: S
authors.initials: S
authors.lastname: Morrison
authors.forename: J P
authors.initials: JP
authors.lastname: MacLeod
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D005260:Female; D006801:Humans; D017240:Mitochondrial Myopathies / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*