title: Post-natal incidence of HIV-I infection among children in a rural Ugandan population: no evidence for transmission other than mother to child.
abstract: We conducted a prospective cohort study to determine the post-natal incidence of and possible transmission routes for HIV-I infection in rural Ugandan children. The cohort consisted of the population of a cluster of 15 villages in Masaka District, south-west Uganda, and was enrolled in 1989-1990 through a demographic and serological survey. During the period 1991-1993 the population was resurveyed annually. A total of 5492 children aged 0-12 years were enrolled; of these, 41 (0.7%) were seropositive infants. A total of 3941 (72%) children were HIV-negative on enrolment and had at least one follow-up specimen. During 8596 person-years of observation only I seroconversion was observed, an incidence rate of 0.12 (95% CI 0.00-0.35) per 1000 years of observation. The transmission of HIV was most probably through breast milk. The case corresponds to a rate of 1.1 per 1000 in households with one or more HIV-positive adults (874 years of observation); no incident case was observed in households with only seronegative adults (6423 years of observation). Thus, HIV infection among children aged 0-12 years in this population is virtually exclusively the result of mother-to-child transmission. No infections were observed attributable to parenteral exposure, non-sexual casual or household contact, or insects.
authors.affiliation: Medical Research Council Programme on AIDS in Uganda (MRC), Uganda Virus Research Institute, Entebbe, Uganda.
authors.forename: D W
authors.initials: DW
authors.lastname: Mulder
authors.forename: A
authors.initials: A
authors.lastname: Nunn
authors.forename: A
authors.initials: A
authors.lastname: Kamali
authors.forename: J F
authors.initials: JF
authors.lastname: Kengeya-Kayondo
mesh_terms: D000293:Adolescent; D000328:Adult; D001942:Breast Feeding; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011159:Population Surveillance; D011446:Prospective Studies; D012423:Rural Health; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D014454:Uganda / Q000453:epidemiology