[Effect of calmodulin antagonist on chemosensitivity of primary cultured lung cancer cells].
The effect of calmodulin antagonist trifluoperazine (TFP) on in vitro drug sensitivity of primary cultured lung cancer cells was studied in 28 cases with MTT assay. TFP was found to enhance significantly the anticancer activities of VCR, ADR and VP16 (P < 0.01 or < 0.05). But TFP could not sensitize tumor cells to DDP. TFP may therefore be useful as an adjunct in chemotherapy of lung cancer.
Xiong
W
W
Southwestern Hospital, Third Military Medical University, Chongqing.
Shen
H
H
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D004317:Doxorubicin / Q000494:pharmacology; D004357:Drug Synergism; D005047:Etoposide / Q000494:pharmacology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014268:Trifluoperazine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D002147:Calmodulin; D014268:Trifluoperazine; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin