title: HLA antigens are candidate markers for prediction of lymph node metastasis in gastric cancer.
abstract: We investigated the association between human leucocyte antigen (HLA) antigens and lymph node metastasis in 724 gastric cancer patients. Among patients who had poorly differentiated adenocarcinoma with or without HLA-DR4 antigen, lymph node metastasis was detected in 80.8 and 54.9%, respectively (relative risk (RR) = 3.5, P = 0.0005, corrected P = 0.0285). It was more common in patients with a family history of cancer death (RR = 7.7). Among signet ring cell carcinoma patients with or without HLA-B52 antigen, lymph node metastasis was detected in 57.7 and 19.7%, respectively (RR = 5.6, P = 0.0001, corrected P = 0.0086). It was more common in patients who were smokers (RR= 8.3). Our findings suggest that HLA-DR4 and HLA-B52 antigens are associated with lymph node metastasis in gastric cancer.
authors.affiliation: Department of Surgery, Tokai University, School of Medicine, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogoshi
authors.forename: T
authors.initials: T
authors.lastname: Tajima
authors.forename: T
authors.initials: T
authors.lastname: Mitomi
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015789:HLA-A2 Antigen / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D059950:HLA-B52 Antigen; D015804:HLA-DR4 Antigen / Q000032:analysis; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D008207:Lymphatic Metastasis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D015804:HLA-DR4 Antigen