title: Laser treatment of recurrent vulvar angiokeratoma associated with Noonan syndrome.
abstract: BACKGROUND
  Vulvar angiokeratoma is often confused with other, more common perineal lesions. Chronically elevated venous pressures may contribute to this rare disorder. Laser treatment may lend palliation for several years.
  
  
  METHODS
  A woman with the characteristic cardiac abnormalities of Noonan syndrome initially responded to Argon laser treatment of vulvar angiokeratoma. Excessive recurrent disease was treated satisfactorily with the Nd:YAG laser.
  
  
  CONCLUSIONS
  Recurrent vulvar angiokeratoma in Noonan syndrome supports the premise that increased persistent central venous pressure may be involved in the disease process.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Meyer
authors.forename: D J
authors.initials: DJ
authors.lastname: Dotters
mesh_terms: D000328:Adult; D000794:Angiokeratoma / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D009634:Noonan Syndrome / Q000150:complications*; D010166:Palliative Care; D012878:Skin Neoplasms / Q000150:complications / Q000601:surgery*; D013997:Time Factors; D014846:Vulvar Neoplasms / Q000150:complications / Q000601:surgery*