Antioxidant behaviors of vitamin E analogues in unilamellar vesicles.
The antioxidant behaviors of vitamin E and its analogues, 2,2,5,7,8-pentamethyl-6-hydroxychroman and 1,2-diacyl-sn-glycero3-phospho-2'-(hydroxyethyl)-2'- 5',7',8'-tetramethyl-6'-hydroxychroman, were studied in unilamellar vesicles. The two analogues scavenged aqueous radicals generated from azo compounds more efficiently than vitamin E. On the other hand, vitamin E scavenged the lipid peroxyl radicals preferentially. It is concluded that the superior antioxidant activity of vitamin E is attributed to its location suitable for breaking the chain propagation reaction.
Koga
T
T
Noda Institute for Scientific Research, Chiba, Japan.
Terao
J
J
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002839:Chromans / Q000737:chemistry / Q000494:pharmacology*; D020404:Glycerophospholipids; D008081:Liposomes; D015394:Molecular Structure; D010712:Phosphatidic Acids / Q000737:chemistry / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000737:chemistry; D013997:Time Factors; D014810:Vitamin E / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
D000975:Antioxidants; D002839:Chromans; D020404:Glycerophospholipids; D008081:Liposomes; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; C057590:phosphatidylcholine hydroperoxide; C086691:phosphatidylchromanol; D014810:Vitamin E; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman