[Characteristics of adaptive reactions of the body's immune system following operations for vascular anomalies].
Analysing the body's responses in 32 patients operated on for cerebral vascular aneurysms has shown that preoperatively there is activation of the peripheral blood antiprotease system, which appears to be associated with the impaired permeability of the vascular wall and with the activation of the hemostatic system and that their liquores contain sensitizing substances which are products of hemorrhages and cerebral detritus. On the whole, the immune responses of this group of patients are common to those of other groups of neurosurgical patients: acute-phase blood reaction, synthesizing-antibody binding of antigens, sanitating and brain tissue-transient neurosensitization. The use of mildronate contributes to the activation of the humoral link of the immune system on post-operative days 5-7, increases the serum antiprotease potential, by intensifying the body's responses, levels stress immunodeficiency and prolongs the time of neurosensitization.
Starchenko
A A
AA
Khil'ko
V A
VA
Gaĭdar
B V
BV
Khlunovskiĭ
A N
AN
Komarets
S A
SA
D000222:Adaptation, Physiological / Q000187:drug effects / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000917:Antibody Formation / Q000187:drug effects; D003131:Combined Modality Therapy; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000503:physiopathology*; D007111:Immunity, Cellular / Q000187:drug effects; D002532:Intracranial Aneurysm / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D008763:Methylhydrazines / Q000627:therapeutic use; D011182:Postoperative Care; D011300:Preoperative Care; D013997:Time Factors
D000276:Adjuvants, Immunologic; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate
Osobennosti adaptatsionnykh reaktsiĭ immunoĭ sistemy organizma posle operatsiĭ po povodu sosudistykh anomaliĭ.