title: Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome.
abstract: OBJECTIVE
  To characterize the visual prognosis of patients with multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), and the diffuse subretinal fibrosis (DSF) syndrome.
  
  
  METHODS
  Forty-one patients with MCP, 16 with PIC, and 5 with DSF syndrome were evaluated. The mean follow-up was approximately 39 months for patients with MCP, 51 months for patients with PIC, and 59 months for patients with DSF syndrome. Complete ophthalmic examinations were performed, and photofiles were reviewed.
  
  
  RESULTS
  The final average visual acuity for patients with MCP was 20/50. Forty-five of the 68 involved eyes (66%) had 20/40 visual acuity or better. Choroidal neovascularization (CNV) developed within choroiditis lesions in 22 (19 patients) of 68 eyes, causing visual acuity poorer than 20/50 in 14 eyes. The final average visual acuity in patients with PIC was 20/39; 23 (77%) of the 30 involved eyes had visual acuity of 20/40 or better. Six of the seven eyes with 20/50 or poorer vision had CNV. Six other eyes had CNV within the macula that regressed spontaneously with good resultant vision. Seven of the ten involved eyes with DSF syndrome had 20/200 or poorer vision. Poor vision was due to fibrosis and atrophy within the macula.
  
  
  CONCLUSIONS
  Most patients with MCP and PIC retained visual acuity of 20/40 or better. In nearly one third of patients with MCP and PIC, CNV developed. Severe visual loss in these diseases was usually due to subfoveal CNV. Patients with DSF syndrome had a poor prognosis due to fibrosis and atrophy involving the macula.
authors.affiliation: Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52240, USA.
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: J C
authors.initials: JC
authors.lastname: Folk
authors.forename: C V
authors.initials: CV
authors.lastname: Reddy
authors.forename: A E
authors.initials: AE
authors.lastname: Kimura
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002829:Choroid / Q000098:blood supply; D015862:Choroid Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D002833:Choroiditis / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005355:Fibrosis; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000601:surgery; D011379:Prognosis; D012160:Retina / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D013577:Syndrome; D014792:Visual Acuity
chemical_list: D000305:Adrenal Cortex Hormones