Structure-function relationships in the Ca(2+)-ATPase of sarcoplasmic reticulum: facts, speculations and questions for the future.
Structural data on the Ca(2+)-ATPase of sarcoplasmic reticulum are integrated with kinetic data on Ca2+ transport. The emphasis is upon ATPase-ATPase interactions, the requirement for phospholipids, and the mechanism of Ca2+ translocation. The possible role of cytoplasmic [Ca2+] in the regulation of the synthesis of Ca(2+)-ATPase is discussed.
Martonosi
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Department of Biochemistry and Molecular Biology, State University of New York, Syracuse 13210, USA.
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology; D000252:Calcium-Transporting ATPases / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D010743:Phospholipids / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D013329:Structure-Activity Relationship
D015220:Calcium Channels; D010743:Phospholipids; D000252:Calcium-Transporting ATPases; D002118:Calcium