[Disseminated infection with Mycobacterium celatum].
A 29-year-old patient with AIDS was hospitalized with weight loss, fever and cough. Mycobacterial cultures from sputum, blood and bronchoalveolar lavage became positive after 3 weeks' incubation. When using a DNA probe for identification of Mycobacterium tuberculosis complex, a weakly positive signal was obtained. Tuberculosis was suspected and treatment was started with isoniazid, ethambutol and ciprofloxacin. Sequencing of the gene of the 16S rRNA, however, identified the isolates as belonging to a new, slow-growing atypical mycobacterial species, Mycobacterium celatum (M. celatum). Treatment was modified to take into account the previously described primary resistance of M. celatum to antituberculous drugs, whereupon the patient improved.
Emler
S
S
Division des maladies infectieuses, Hôpitaux universitaires de Genève.
Praplan
P
P
Rohner
P
P
Auckenthaler
R
R
Hirschel
B
B
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000328:Adult; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000382:microbiology*; D009170:Nontuberculous Mycobacteria / Q000235:genetics / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents
Disseminierte Infektion mit Mycobacterium celatum.