title: [Digital necrosis associated with fenoxazoline poisoning. Apropos of a case and review of the literature].
abstract: We report the case of a 53 year-old woman with paroxystic hypertension and digital ischemia. The only triggering factor was chronic intoxication by a nasal vasoconstrictor:fenoxazoline. The worsening of the lesions required amputation of the third phalanx of the 3rd and 5th finger and the pulp of the 4th finger of the left hand. The review of literature exhibits association between fenoxazoline intoxication and paroxystic hypertension, myocardial ischemia or stroke, but association between fenoxazoline intoxication and digital ischemia has never been reported. We emphasize the extreme caution necessary with the prescription and the chronic consumption of this kind of drug.
authors.affiliation: Service de néphrologie et réanimation médicale, CHU de Poitiers, France.
authors.forename: T
authors.initials: T
authors.lastname: Hauet
authors.forename: A
authors.initials: A
authors.lastname: Ramassamy
authors.forename: P
authors.initials: P
authors.lastname: Badia
authors.forename: N
authors.initials: N
authors.lastname: Julien
authors.forename: R
authors.initials: R
authors.lastname: Robert
authors.forename: G
authors.initials: G
authors.lastname: Touchard
authors.forename: D
authors.initials: D
authors.lastname: Patte
mesh_terms: D005260:Female; D005385:Fingers / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D007093:Imidazoles / Q000506:poisoning*; D007511:Ischemia / Q000139:chemically induced*; D008875:Middle Aged; D014663:Nasal Decongestants / Q000506:poisoning*; D009336:Necrosis; D014034:Toes / Q000098:blood supply / Q000473:pathology
chemical_list: D007093:Imidazoles; D014663:Nasal Decongestants; C040400:fenoxazoline
vernacular_title: Nécrose digitale associée à une intoxication par la fenoxazoline. A propos d'un cas et revue de la littérature.