title: Central venous catheter infection by Aspergillus fumigatus in a patient with B-type non-Hodgkin lymphoma.
abstract: Invasive Aspergillus infection is still a major problem in immunocompromised patients. A central venous catheter infection by Aspergillus fumigatus, however, has not yet been reported. We describe the case of a 10-year-old female patient with B-type non-Hodgkin lymphoma treated according to the German chemotherapy protocol NHL-BFM 90. Isolation of Aspergillus fumigatus from the blood was the first hint of invasive aspergillosis. A central venous catheter-associated infection was suggested, since Aspergillus was also isolated from the thrombotic tip of the removed catheter. Secondary pulmonary aspergillosis was documented radiologically. The patient was treated successfully by Ampho-thericin B and Itraconazol and explantation of the central venous catheter under conditions of complete hematopoietic regeneration of the bone marrow with omission of the final chemotherapeutic cycle.
authors.affiliation: University Children's Hospital Freiburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Berner
authors.forename: S
authors.initials: S
authors.lastname: Sauter
authors.forename: Y
authors.initials: Y
authors.lastname: Michalski
authors.forename: C M
authors.initials: CM
authors.lastname: Niemeyer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001228:Aspergillosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001232:Aspergillus fumigatus; D002051:Burkitt Lymphoma / Q000188:drug therapy*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling; D002648:Child; D005260:Female; D016469:Fungemia / Q000175:diagnosis; D006801:Humans; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000209:etiology; D011859:Radiography