title: Functional and antiischaemic effects of Monoacetyl-vitexinrhamnoside in different in vitro models.
abstract: 1. Functional and antiischaemic effects of monoacetyl-vitexinrhamnoside (AVR), a flavonoid with phosphodiesterase (PDE)-inhibitory properties contained in Crataegus species (Hawthorn, Rosaceae) were studied in several in-vitro models. 2. In rabbit isolated femoral artery rings, AVR concentration-dependently reduced developed tension. Vasodilation by AVR was reduced after inhibiting EDRF formation by L-NG-nitro arginine. 3. In spontaneously-beating Langendorff-guinea pig hearts, AVR concentration-dependently enhanced heart-rate, contractility, lusitropy and coronary flow. 4. In isolated electrically-driven Langendorff-rabbit hearts, acute regional ischemia (MI) was induced by coronary artery occlusion and quantified from epicardial NADH-fluorescence photography. AVR (5 x 10(-5) mol/l) induced a slight numerical increase of left ventricular pressure and coronary flow (p > 0.05). MI was reduced (p < 0.05). 5. Monoacetyl-vitexinrhamnoside is an inodilator whose vasodilatory action may be mediated in part by EDRF in addition to PDE-inhibition. Monoacetyl-vitexinrhamnoside does possess marked antiischemic properties even in isolated hearts, suggesting an improvement of myocardial perfusion.
authors.affiliation: Institut für Pharmakologie, Universität Köln, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schüssler
authors.forename: J
authors.initials: J
authors.lastname: Hölzl
authors.forename: A F
authors.initials: AF
authors.lastname: Rump
authors.forename: U
authors.initials: U
authors.lastname: Fricke
mesh_terms: D000019:Abortifacient Agents / Q000494:pharmacology; D000818:Animals; D047310:Apigenin; D015237:Dinoprost / Q000494:pharmacology; D005263:Femoral Artery / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D017202:Myocardial Ischemia / Q000517:prevention & control; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D013373:Substance P / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D000019:Abortifacient Agents; D005419:Flavonoids; D010936:Plant Extracts; C021329:vitexin rhamnoside; D013373:Substance P; D047310:Apigenin; D015237:Dinoprost