title: An analysis of surveillance for stage I combined teratoma--seminoma of the testis.
abstract: We analysed 973 patients with stage I testicular tumours presenting between 1983 and 1994. The median ages at presentation for non-seminomatous germ cell tumour (teratoma) were 27 years, seminoma 36 years and combined tumour 33 years. These differences were statistically significant (Mann-Whitney P < 0.05), suggesting that combined tumours may have a separate natural history. We, therefore, analysed all stage I patients managed with surveillance (530 in total) post orchidectomy. The actuarial 5 year relapse-free survival and anatomical patterns of relapse were identical for non-seminomatous germ cell tumour (NSGCT) and combined tumour and both were statistically distinct from seminoma (P = 0.01, log-rank test, chi-square test P = 0.001). The association of seminoma within a histologically confirmed NSGCT has no influence on the clinical outcome.
authors.affiliation: Academic Urology Unit, Royal Marsden NHS Trust, Sutton, Surrey, UK.
authors.forename: R
authors.initials: R
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Dearnaley
authors.forename: J
authors.initials: J
authors.lastname: Nicholls
authors.forename: A
authors.initials: A
authors.lastname: Norman
authors.forename: S
authors.initials: S
authors.lastname: Sampson
authors.forename: A
authors.initials: A
authors.lastname: Horwich
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D009919:Orchiectomy; D011379:Prognosis; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D018239:Seminoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D013724:Teratoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D016896:Treatment Outcome