Failure of excitatory amino acids receptor agonists NMDA and quiscalate to affect the cell proliferation.
The effects of NMDA and quiscalate on proliferation of primary cell cultures of human glioma, rat estrogen induced pituitary tumor and mouse spleen lymphocytes were investigated in vitro. The tritiated thymidine incorporation into DNA was used as an index of cell proliferation. Neither NMDA nor quiscalate affected the tritiated thymidine incorporation in the cell cultures herein studied. This finding contradicts the idea of the involvement of EAA receptors in the control of cell proliferation although does not exclude it.
Pawlikowski
M
M
Institute of Endocrinology, Medical Academy, Lódź, Poland.
Kunert-Radek
J
J
D000368:Aged; D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005260:Female; D005909:Glioblastoma / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D016202:N-Methylaspartate / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000473:pathology
D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate