Antagonism of behavioral effects of electroconvulsive shock but not those of desipramine by the selective 5-HT-3 receptor antagonist, ondansetron.
The influence of ondansetron (ON) on desipramine (DMI) and electroconvulsive shock (ECS) effects in the open field (OFT) and forced swim test (FST) were studied in Wistar male rats. ON failed to influence the action of DMI but abolished stimulatory effect of ECS in the OFT and, in the lower dose (0.01 mg/kg) reduced ECS action in the FST. This result suggests that 5-HT-3 receptors are involved in behavioral effects of ECS but not DMI.
Kostowski
W
W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Płaźnik
A
A
Nazar
M
M
Jessa
M
M
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003891:Desipramine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004597:Electroshock; D008297:Male; D017294:Ondansetron / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D012702:Serotonin Antagonists; D017294:Ondansetron; D003891:Desipramine