Alterations in the systemic acid-base status and blood gas dynamics during progressive hypocalcaemia in cow calves.
Hypocalcaemia, induced in cow calves by slow infusion of Na2EDTA for 6 hr, led to biphasic changes in acid-base status. Decrease in ionized plasma Ca2+ concentration upto 0.82 +/- 0.06 mmole 1(-1) was associated with metabolic alkalosis. Further decrease in ionized plasma Ca2+ concentration (0.61 +/- 0.09 mmole 1(-1)) led to metabolic acidosis, superimposed by a respiratory component. There was significant decrease in oxygen tension and saturation of arterial blood as well as impaired uptake of oxygen by peripheral tissues and pulmonary blood.
Setia
M S
MS
Department of Veterinary Physiology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
Singh
A
A
Kahlon
R S
RS
Randhawa
S S
SS
D000137:Acid-Base Imbalance / Q000209:etiology*; D000818:Animals; D001784:Blood Gas Analysis; D002417:Cattle; D018450:Disease Progression; D006996:Hypocalcemia / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D008297:Male