title: The mononuclear phagocyte-dendritic cell dichotomy: myths, facts, and a revised concept.
abstract: Since Aschoff's reticuloendothelial system was abandoned a few decades ago, classification and characterization of the mononuclear phagocyte and dendritic cell systems have evolved separately or even in competition with one another. New information has now become available indicating that monocytes/macrophages and dendritic cells have a common origin in the bone marrow, and may even transdifferentiate. Morphological and functional distinctions-although valid under certain conditions-have been blurred by revelation of the versatility of monocytes/macrophages and dendritic cells in response to different contextual needs in inflammation and immunity. Monocytes/macrophages and dendritic cells share a sentinel, receptor/effector, and presentation mode, and may either activate or silence specific immune reactions. In keeping with the view of monocytes/macrophages and dendritic cells as interactive sentinels, we suggest that the mono-nuclear phagocyte and dendritic cell systems be replaced by the custocyte system (custos, Lat = sentinel, guard) as a unifying concept. Within the custocyte system, we recognize type I, type II, and type III custocytes. Type I and II custocytes exhibit predominance of presentation or effector/presenter interdependency, respectively, while type III custocytes are bipolar, passing through type I- and type II-like phases during their development and in inflammatory responses. The custocyte system brings into view monocytes/macrophages and dendritic cells as dynamic players in immunity and inflammation with a high degree of derivational, phenotypic, functional, and molecular plasticity.
authors.affiliation: Hautklinik und Poliklinik, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Goerdt
authors.forename: V
authors.initials: V
authors.lastname: Kodelja
authors.forename: M
authors.initials: M
authors.lastname: Schmuth
authors.forename: C E
authors.initials: CE
authors.lastname: Orfanos
authors.forename: C
authors.initials: C
authors.lastname: Sorg
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology; D006801:Humans; D010586:Phagocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology