Etiology of the acrodermatitis chronica atrophicans lesion in Lyme disease.
Spirochete diversity in acrodermatitis chronica atrophicans lesions in a closely defined central European site was compared to that in the local vector population, in human erythema migrans lesions, and in cerebrospinal fluid by amplifying and sequencing a segment of the gene of outer surface protein A directly from sampled tissues. Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi acutely infect human skin and invade internal tissues. Only B. afzelii, however, is associated with acrodermatitis chronica atrophicans lesions, persisting chronically where the skin has atrophied.
Ohlenbusch
A
A
Abteilung Medizinische Mikrobiologie, Universitätskliniken der Georg-August-Universität Göttingen, Germany.
Matuschka
F R
FR
Richter
D
D
Christen
H J
HJ
Thomssen
R
R
Spielman
A
A
Eiffert
H
H
D000169:Acrodermatitis / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology*; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001428:Bacterial Vaccines; D001898:Borrelia / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D001899:Borrelia Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008074:Lipoproteins; D008193:Lyme Disease / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013987:Ticks / Q000382:microbiology
D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; C072045:OspA protein