[DNA cytometry of solitary and aneurysmal bone cysts and low malignancy and high malignancy central osteosarcomas. Current significance within the scope of morphologic diagnosis of intraosseous cystic and osteoblastic lesions].
DNA cytometric investigations of intraosseous cystic lesions and osteoblastic tumors may be helpful in morphological diagnosis. The detection of a DNA-aneuploid stemline supports the diagnosis of a high-grade malignant bone neoplasm, even in small biopsies. Solitary and aneurysmal bone cysts have DNA-diploid cell populations. Low-grade central osteosarcomas may show single-cell aneuploidies of varying extent as well as a DNA-diploid stemline. Their presence may be a sign of genetic instability within the population of neoplastic cells before a DNA-aneuploid stemline is established and should prompt careful postoperative observation.
Werner
M
M
Abteilung für Osteopathologie, Institut für Pathologie der Universität, Hamburg.
Heintz
A
A
Delling
G
G
D000782:Aneuploidy; D001845:Bone Cysts / Q000235:genetics / Q000473:pathology*; D017824:Bone Cysts, Aneurysmal / Q000235:genetics / Q000473:pathology*; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology; D012516:Osteosarcoma / Q000235:genetics / Q000473:pathology*; D011379:Prognosis
D004273:DNA, Neoplasm
DNA-Zytometrie an solitären und aneurysmatischen Knochen-zysten sowie niedrigmalignen und hochmalignen zentralen Osteosarkomen. Gegenwärtige Bedeutung im Rahmen der morphologischen Diagnostik intraossärer zystischer und osteoblastischer Läsionen.