[In vitro growth of skin fibroblasts of patients with atypical ductal hyperplasia of the breast: effects of 17 beta-estradiol].
In this work we investigated the growth of skin fibroblasts, in vitro cultured, drawn from women suffering Atypical Ductal Hyperplasia (I.D.A.) and from healthy women (controls). Whether in basic conditions or after administration of 17, beta-estradiol, in single of repeated dose, cellular growth was valued. The results obtained show that skin fibroblasts drawn from women suffering I.D.A. treated with 100 microliters/ml of estradiol (effective dose), have an increase of the growth. Moreover the increase of the growth seems to be bequest to "effective dose" but not to the number of administrations.
Ricciardi
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Università degli Studi dell'Aquila, Facoltà di Medicina e Chirurgia.
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D000328:Adult; D001940:Breast / Q000187:drug effects / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D002478:Cells, Cultured; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008875:Middle Aged; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004958:Estradiol
Crescita in vitro di fibroblasti cutanei di pazienti affette da iperplasia duttale atipica della mammella: effetti del 17-beta-estradiolo.