title: Gingival Langerhans' cells in type I diabetes mellitus.
abstract: Langerhans' cells (LCs) are intraepithelial immunocompetent cells. Changes in the number of LCs occur in inflammatory and autoimmune diseases. In this study, the number of gingival LCs in patients with type I diabetes mellitus was compared with those of normal individuals using immunohistochemical methods. Gingival biopsies were obtained from 20 type I diabetics and 10 healthy individuals. Anti-CD1 positive LCs formed an intraepithelial network and showed a marked increase in type I diabetics. This increase was not related to diabetic age. The number of LCs was proportional to the density of subepithelial inflammatory cells. Our findings suggest that LCs may play a role in the development of diabetic gingivitis.
authors.affiliation: Department of Periodontology, University of Ankara, School of Dentistry, Beşevler Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Günhan
authors.forename: O
authors.initials: O
authors.lastname: Günhan
authors.forename: B
authors.initials: B
authors.lastname: Celasun
authors.forename: O
authors.initials: O
authors.lastname: Azal
authors.forename: H
authors.initials: H
authors.lastname: Bostanci
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018949:Antigens, CD1 / Q000032:analysis; D001706:Biopsy; D002452:Cell Count; D003593:Cytoplasm / Q000648:ultrastructure; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D004487:Edema / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005881:Gingiva / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology
chemical_list: D018949:Antigens, CD1