Acute pandysautonomia: mass spectrometric and histopathological studies of the sympathetic nervous system during long term L-threo-3,4-dihydroxyphenylserine treatment.
Stable isotope labelled L-threo-3,4-dihydroxyphenylserine (L-DOPS) infusion tests and histopathological studies of the rectal autonomic nerves were performed in a patient with acute pandysautonomia. A pronounced increase in blood pressure occurred and stable isotope labelled noradrenaline appeared in the plasma during L-DOPS infusion in the acute stage, but decreased during the next three years. Noradrenergic nerve fibres in the rectal mucosa showed no recovery, and so clinical improvement had occurred without apparent significant regeneration of the peripheral autonomic nerves.
Ushiyama
M
M
Department of Neurology, Kenwakai Hospital, Iida, Japan.
Ikeda
S
S
Suzuki
T
T
Yazawa
M
M
Yanagisawa
N
N
Tsujino
S
S
D000208:Acute Disease; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D015103:Droxidopa / Q000494:pharmacology* / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007024:Hypotension, Orthostatic; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D012007:Rectum / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology*; D016896:Treatment Outcome
D015103:Droxidopa; D009638:Norepinephrine