title: Dynamic contrast-enhanced subtraction versus T2-weighted spin-echo MR imaging in the follow-up of colorectal neoplasm: a prospective study of 41 patients.
abstract: OBJECTIVE
  To compare dynamic contrast-enhanced subtraction (DCES) and T2-weighted spin-echo (SE) magnetic resonance (MR) imaging in the differentiation of fibrosis from recurrence during the follow-up of treated colorectal neoplasms.
  
  
  METHODS
  Forty-one patients with 39 malignant and 16 benign lesions confirmed by means of surgery (n = 23), biopsy (n = 24), or 12-month follow-up examination (n = 8) underwent DCES MR imaging and T2-weighted SE MR imaging. Enhancement of an abnormal pelvic structure within the first 90 seconds on DCES images or high signal intensity on T2-weighted SE images was considered indicative of malignancy.
  
  
  RESULTS
  Sensitivity, specificity, and positive and negative predictive values were, respectively, 97%, 81%, 93%, and 100% for DCES MR imaging and 77%, 56%, 81%, and 56% for T2-weighted MR imaging. The number of correctly classified lesions was significantly higher with DCES imaging compared with T2-weighted imaging (P < or = .006).
  
  
  CONCLUSIONS
  DCES imaging is more accurate than T2-weighted SE imaging for differentiating fibrosis from recurrence during the follow-up of treated colorectal neoplasms.
authors.affiliation: Department of Radiology, Institut Gustave Roussy, Villejuif, France.
authors.forename: K
authors.initials: K
authors.lastname: Kinkel
authors.forename: A A
authors.initials: AA
authors.lastname: Tardivon
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: A
authors.initials: A
authors.lastname: Spatz
authors.forename: P
authors.initials: P
authors.lastname: Lasser
authors.forename: P
authors.initials: P
authors.lastname: Rougier
authors.forename: D
authors.initials: D
authors.lastname: Vanel
mesh_terms: D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000175:diagnosis; D005500:Follow-Up Studies; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D010386:Pelvic Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012007:Rectum / Q000473:pathology; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D013997:Time Factors
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA; C072417:gadoterate meglumine