Cimetidine does not alter sparfloxacin pharmacokinetics.
The interaction between cimetidine and sparfloxacin was studied in 10 healthy volunteers who received a single oral dose of 400 mg sparfloxacin on the third day of an 8 day cimetidine (400 mg t.i.d.) or placebo randomly assigned treatment. No statistically significant differences were observed in the pharmacokinetic parameters (Cmax-AUC-T1/2-urinary excretion and metabolic ratio) of sparfloxacin following the 2 treatment. Cimetidine does not affect absorption, metabolism or urinary excretion of sparfloxacin; consequently, patients exposed to this drug combination are not at risk.
Gries
J M
JM
Clinical Pharmacy, Hôpital Necker, Paris, France.
Honorato
J
J
Taburet
A M
AM
Alvarez
M P
MP
Sadaba
B
B
Azanza
J R
JR
Singlas
E
E
D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002927:Cimetidine / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D024841:Fluoroquinolones; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015363:Quinolones / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D006635:Histamine H2 Antagonists; D015363:Quinolones; D002927:Cimetidine; C061363:sparfloxacin