Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier.
Basigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of basigin in adult mice lacking the gene [Bsg (-1-)]. Although histochemical studies on the localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved in the function of the blood-brain barrier, basigin knockout mice showed only a little difference, if any, to wild-type mice in the function of the blood brain-barrier. The mitogenic response of lymphocytes upon mixed lymphocyte reaction was greater in Bsg (-1-) mice. Finally, Bsg (-1-) mice repeatedly visited filter paper impregnated with acetic acid or isozine, indicating an abnormality in either reception of the odor or behavior as to it.
Igakura
T
T
Department of Biochemistry, Nagoya University School of Medicine, Japan.
Kadomatsu
K
K
Taguchi
O
O
Muramatsu
H
H
Kaname
T
T
Miyauchi
T
T
Yamamura
K
K
Arimura
K
K
Muramatsu
T
T
D000818:Animals; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface / Q000502:physiology; D030161:Avian Proteins; D051926:Basigin; D001522:Behavior, Animal; D001798:Blood Proteins; D001812:Blood-Brain Barrier / Q000502:physiology*; D007509:Irritants; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009812:Odorants; D013154:Spleen / Q000276:immunology
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C497887:Bsg protein, mouse; C079432:Bsg protein, rat; D007509:Irritants; D008562:Membrane Glycoproteins; D051926:Basigin