title: Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins.
abstract: We have observed that alpha endosulfine, the 13KDa form of the endogenous ligand for sulfonylurea receptor recently isolated from porcine brain, displays strong similarities with a phosphoprotein of similar size previously isolated from bovine brain and called ARPP-19. To determine whether the two proteins are different entities, we developed an RT-PCR strategy for analyzing the main portion of bovine alpha endosulfine. We show that alpha endosulfine and ARPP-19 are different entities from the same family of proteins, coded by distinct genes.
authors.affiliation: INSERM U 376, CHU Arnaud-de-Villeneuve, Montpellier, France.
authors.forename: K
authors.initials: K
authors.lastname: Peyrollier
authors.forename: L
authors.initials: L
authors.lastname: Héron
authors.forename: A
authors.initials: A
authors.lastname: Virsolvy-Vergine
authors.forename: A
authors.initials: A
authors.lastname: Le Cam
authors.forename: D
authors.initials: D
authors.lastname: Bataille
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003001:Cloning, Molecular; D017931:DNA Primers; D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry*; D010750:Phosphoproteins / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
chemical_list: D017931:DNA Primers; D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D010750:Phosphoproteins; D011994:Recombinant Proteins; C064321:cyclic AMP-regulated phosphoprotein 19; C483180:endos protein, Drosophila; C075663:endosulfine