Leishmaniasis presenting as a dermatomyositis-like eruption in AIDS.
Three patients are described with leishmaniasis and AIDS, with cutaneous lesions mimicking dermatomyositis. Leishmania organisms were observed in great numbers in the dermis of lesional skin biopsy specimens. They were also present inside keratinocytes in all layers of the epidermis in one patient. Skin cultures from all patients and bone marrow culture in patients 1 and 3 revealed Leishmania infantum. Leishmania organisms were also found in nonlesional skin. The absence of proximal symmetric muscle weakness, elevated muscle enzymes, myopathic electromyograms, or characteristic histopathologic and immunologic features of dermatomyositis, and the rapid and complete clearance or marked improvement of the cutaneous lesions after treatment for leishmaniasis, make us consider true dermatomyositis unlikely. We suggest that leishmaniasis be included in the list of diseases capable of inducing a dermatomyositis-like eruption.
Daudén
E
E
Department of Dermatology, Hospital de la Princesa, Universidad Autónoma, Madrid, Spain.
Peñas
P F
PF
Rios
L
L
Jimenez
M
M
Fraga
J
J
Alvar
J
J
García-Diez
A
A
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D000818:Animals; D001415:Back; D003882:Dermatomyositis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004817:Epidermis / Q000469:parasitology; D005148:Facial Dermatoses / Q000469:parasitology; D006679:HIV Seropositivity; D006229:Hand Dermatoses / Q000469:parasitology; D006801:Humans; D015603:Keratinocytes / Q000469:parasitology; D018314:Leishmania infantum / Q000302:isolation & purification; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000469:parasitology