title: The biology of HMG-CoA reductase: the pros of contra-regulation.
abstract: Hydroxymethylglutaryl-CoA reductase (HMG-R) is a key enzyme in the mevalonate pathway, from which thousands of molecules are derived including cholesterol and prenyl moieties. The regulation of HMG-R is complex and includes feedback control, cross-regulation by independent bio-chemical processes and contra-regulation of separate isozymes. From studies in yeast, these separate modes of regulation can be considered in an integrated fashion.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093, USA.
authors.forename: R
authors.initials: R
authors.lastname: Hampton
authors.forename: D
authors.initials: D
authors.lastname: Dimster-Denk
authors.forename: J
authors.initials: J
authors.lastname: Rine
mesh_terms: D005246:Feedback; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000502:physiology*; D007527:Isoenzymes / Q000502:physiology*; D005810:Multigene Family; D012441:Saccharomyces cerevisiae / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D006903:Hydroxymethylglutaryl CoA Reductases