14q+ chromosome marker in a T-cell-rich B-cell lymphoma.
Cytogenetic, in situ hybridization, and molecular studies were performed in a case of T-cell-rich B-cell lymphoma. Demonstration of Ig gene rearrangements for both heavy and light chains confirmed the B-lineage restriction of the neoplastic cell population. Moreover, as expected in B-cell malignancies, all abnormal karyotypes showed a 14q+ chromosome marker involving 14q32. The origin of the extra material on the derivative 14q+, as defined by chromosome painting with a library for chromosome 11, and Southern blotting for c-myc and bcl-2 rearrangements, remains unknown.
La Starza
R
R
Hematology, University of Perugia, Italy.
Aventin
A
A
Falzetti
D
D
Stul
M
M
Martelli
M F
MF
Falini
B
B
Mecucci
C
C
D015139:Blotting, Southern; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
D005819:Genetic Markers