title: [Assessment of residual mediastinal tumor in patients with Hodgkin's lymphoma using computed tomography, magnetic resonance and 67Ga scintigraphy].
abstract: 594 patients with Hodgkin's disease were treated from 1983 to 1993 at the Department of Radiotherapy and Institute of Hematology, "La Sapienza" University, Rome, Italy. 385 patients presented mediastinal involvement; CT and/or chest radiography showed residual mediastinal masses in 96 of them (25%). In this study we included only the patients treated after 1986; they were examined with MRI of the chest (24 patients) and 67Gallium scintigraphy of the mediastinum (44 patients) with or without SPECT, combined with high-dose 67Ga in some cases. Eighteen patients underwent both MRI and 67Gallium scintigraphy. MR accuracy, sensitivity and specificity were respectively 75%, 86% and 86%; gallium scintigraphy had 86%, 77% and 93%. These data were confirmed by the results fo the subgroup of 18 patients submitted to both exams; MRI had higher sensitivity (80% vs. 75%) and lower specificity and accuracy (83% vs. 80% and 72% vs. 67, respectively) than 67Gallium scintigraphy. The predictive value of MR-scintigraphy agreement is high: indeed, no false negatives or false positives were observed when MR and scintigraphy results were in agreement.
authors.affiliation: Cattedra di Radioterapia Oncologica, Università degli Studi di Roma, La Sapienza.
authors.forename: A
authors.initials: A
authors.lastname: Capua
authors.forename: M F
authors.initials: MF
authors.lastname: Osti
authors.forename: F
authors.initials: F
authors.lastname: Scattoni Padovan
authors.forename: R
authors.initials: R
authors.lastname: Sarra
authors.forename: S
authors.initials: S
authors.lastname: Sbarbati
authors.forename: A P
authors.initials: AP
authors.lastname: Anselmo
authors.forename: R
authors.initials: R
authors.lastname: Maurizi Enrici
mesh_terms: D005188:False Negative Reactions; D005189:False Positive Reactions; D005500:Follow-Up Studies; D005710:Gallium Radioisotopes; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology; D018365:Neoplasm, Residual; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes
vernacular_title: Valutazione del residuo mediastinico nei pazienti affetti da linfoma di Hodgkin con Tomografia Computerizzata, Risonanza Magnetica e oncoscintigrafia con 67Ga.