Migraine with aura: segregation analysis and heritability estimation.
A genetic study was performed in a group of 60 migraine patients and their first-degree relatives as well as in a group of sex- and age-matched controls. Segregation analysis showed that multifactorial inheritance seems to be the most probable mode of genetic transmission. Heritabilities were estimated according to the sex of probands and relatives. Our findings favor multifactorial inheritance, but the contribution of a major gene can not be excluded.
Kalfakis
N
N
Department of Neurology, Athens (Greece) National University, Eginition Hospital.
Panas
M
M
Vassilopoulos
D
D
Malliara-Loulakaki
S
S
D000328:Adult; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000145:classification / Q000235:genetics*; D008957:Models, Genetic; D017678:Sex Distribution