[Reference values in biological monitoring of occupational exposure to mutagens and carcinogens].
This work reports values of biological markers indicating mutagenic/carcinogenic risk in professionally non-exposed populations. The main confounding factors for most of these biomarkers are tobacco smoke, diet and air pollution. With the sole exception of compounds specifically present in work environments, in which determination in biological fluids of unchanged substances or their metabolites has high sensitivity and specificity (e.g., some aromatic amines), other biomarkers (urinary mutagenicity, DNA adducts and cytogenetic analyses), in order to be used properly as reference values, require ad hoc study of suitable control groups paired for the main confounding factors. Analytical determination of some protein adducts appears to be promising, due to its sensitivity and specificity.
Clonfero
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Istituto di Medicina del Lavoro, Università di Padova.
Pavanello
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D000393:Air Pollutants / Q000633:toxicity; D015415:Biomarkers / Q000032:analysis*; D002273:Carcinogens / Q000032:analysis*; D002478:Cells, Cultured; D018736:DNA Adducts / Q000032:analysis; D004032:Diet; D004784:Environmental Monitoring / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis*; D016273:Occupational Exposure / Q000592:standards*; D012016:Reference Values; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012907:Smoking
D000393:Air Pollutants; D015415:Biomarkers; D002273:Carcinogens; D018736:DNA Adducts; D009153:Mutagens
Valori di riferimento nel monitoraggio biologico dell'esposizione professionale ad agenti mutageni e cancerogeni.