[Microproteinuria and circadian rhythm of blood pressure in patients with arterial hypertension].
Microproteinuria is a recognized sign of early nephropathy in the course of arterial hypertension. There is few data concerning the excretion of proteins other than albumin in this group of patients. The aim of the study was to examine circadian rhythm of alfa-l-microglobulin (AlMG), albumin (ALB), immunoglobulin G (IgG) excretion and N-acetyl-beta-glukosaminidase (beta NAG)-activity, then to compare the results with the results of 24 hour ambulatory monitoring of arterial blood pressure in patients with arterial hypertension. The study comprised 28 patients. The control group included 27 healthy volunteers. Albumin concentration was determined by Beckman ICS2 nephelometer, using Beckman and Dako reagents. Blood pressure and ECG were monitored by analysis with ABP-system (AMP-USA). In patients with arterial hypertension significantly higher levels of ALB, AlMG, IgG and increased beta NAG activity were observed in morning urine samples. Despite hypotensive treatment blood pressure values were slightly, though significantly higher than in the control group. Among patients in the study circadian BP rhythm was disturbed. The results obtained suggest that in this group of patients subclinical nephropathy develops involving renal glomeruli and proximal tubules--probably resulting from vascular and humoral disorders, with accompanied hypertension.
Marczewski
K
K
Przychodni Chorób Zawodowych Wsi Instytutu Medycyny Wsi w Lublinie.
Krawczyk
W
W
Grzywna
R
R
Rózyc
P
P
Jarosz
M
M
Raszewski
G
G
Klimek
K
K
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000419:Albuminuria / Q000503:physiopathology; D000510:Alpha-Globulins / Q000652:urine; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007074:Immunoglobulin G / Q000652:urine; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000652:urine; D011507:Proteinuria / Q000209:etiology / Q000503:physiopathology*
D000510:Alpha-Globulins; D007074:Immunoglobulin G; D011480:Protease Inhibitors; C016001:alpha-1-microglobulin; D000118:Acetylglucosaminidase
Mikroproteinuria i rytm dobowy ciśnienia u pacjentów z nadciśnieniem tetniczym.