title: Expression and signal transduction of the FLT3 tyrosine kinase receptor.
abstract: FLT3 is a receptor tyrosine kinase of 130-55 kDa expressed on normal bone marrow stem and early progenitor cells and on leukemic blasts from patients with acute leukemias. The FLT3 ligand, FL, is a new cytokine which acts on hematopoietic progenitors in synergy with other cytokines. FLT3 transduces FL-mediated signal through interaction with a number of cytoplasmic substrates.
authors.affiliation: Laboratory of Molecular Oncology, U.119 INSERM, Marseille, France.
authors.forename: O
authors.initials: O
authors.lastname: Rosnet
authors.forename: H J
authors.initials: HJ
authors.lastname: Bühring
authors.forename: O
authors.initials: O
authors.lastname: deLapeyrière
authors.forename: N
authors.initials: N
authors.lastname: Beslu
authors.forename: C
authors.initials: C
authors.lastname: Lavagna
authors.forename: S
authors.initials: S
authors.lastname: Marchetto
authors.forename: I
authors.initials: I
authors.lastname: Rappold
authors.forename: H G
authors.initials: HG
authors.lastname: Drexler
authors.forename: F
authors.initials: F
authors.lastname: Birg
authors.forename: R
authors.initials: R
authors.lastname: Rottapel
authors.forename: C
authors.initials: C
authors.lastname: Hannum
authors.forename: P
authors.initials: P
authors.lastname: Dubreuil
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
mesh_terms: D000208:Acute Disease; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D019143:Evolution, Molecular; D015870:Gene Expression; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D010766:Phosphorylation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D051941:fms-Like Tyrosine Kinase 3
chemical_list: D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; C084881:flt3 ligand protein; C497970:FLT3 protein, human; C497971:Flt3 protein, mouse; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3