title: [Hemorrhagic shock and fulminant hepatic failure associated with valproate].
abstract: Fulminant hepatic failure is an uncommon adverse effect of valproate treatment. Despite an increased use of valproate, since the drug was introduced in 1978, a decline in the number of reported cases has been observed. Here a case of hemorrhagic shock and fulminant hepatic failure in a patient treated with valproate is presented. We emphasize the diagnostic difficulties from the point of view of recognition of the clinical manifestations as well as the biochemical monitoring.
authors.affiliation: Servicio de Medicina Interna, Universidad de Santiago de Compostela, La Coruña.
authors.forename: F J
authors.initials: FJ
authors.lastname: Fernandez-Fernandez
authors.forename: J
authors.initials: J
authors.lastname: Garcia-Rego
authors.forename: A
authors.initials: A
authors.lastname: Garcia-Jimenez
authors.forename: P
authors.initials: P
authors.lastname: Sesma
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D012771:Shock, Hemorrhagic / Q000139:chemically induced*; D013226:Status Epilepticus / Q000188:drug therapy*; D013997:Time Factors; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid
vernacular_title: Shock hemorrágico e insuficiencia hepática fulminante asociada a valproato.