Radioresistant DNA synthesis in fibroblast cell lines derived from LEC strain rats.
Immortalized cell lines from LEC strain (LEC) rats by SV40 large T antigen were more sensitive to X-irradiation than the cell lines from WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a steep decline at low doses and a shallow decline at high doses. On the contrary, the dose-response curves for LEC-derived cell lines showed no steep component; they were almost identical to the shallow component of the curves for WKAH-derived cells.
Hayashi
M
M
Department of Veterinary Radiology, Rakuno Gakuen University, Ebetsu, Japan.
Ishimori
K
K
Maeda
A
A
Watanabe
T
T
Arai
S
S
Okui
T
T
D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D002455:Cell Division; D002461:Cell Line, Transformed; D002470:Cell Survival; D004261:DNA Replication / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects*; D008168:Lung; D011836:Radiation Tolerance; D051381:Rats; D013539:Simian virus 40 / Q000276:immunology
D000952:Antigens, Polyomavirus Transforming