title: Computed tomography and granulocyte scintigraphy in active inflammatory bowel disease. Comparison with endoscopy and operative findings.
abstract: The accuracy of computed tomography (CT) and [99mTc]HMPAO granulocyte scintigraphy (GS) for detection of bowel localization, inflammatory activity, and complications in acute inflammatory bowel disease (IBD) was prospectively studied in 32 patients. Of each bowel segment, findings on CT and GS were scored by one blinded observer. Findings on operation or endoscopy served as the gold standard. In Crohn's disease (CD, 17 patients), CT detected bowel pathology (sensitivity 71%, specificity 98%), abscesses (sensitivity and specificity 100%), and fistulas (sensitivity 80%, specificity 100%). In CD, GS had a sensitive of 79% and a specificity of 98% for detection of inflammatory activity. The detection of complications with GS was poor. Segmental inflammatory activity correlated with endoscopy-operative findings for CT (r = 0/86, P < 0.0001) and GS (r = 0.86, P < 0.0001). In ulcerative colitis (UC, 15 patients), GS predicted proximal extension of bowel involvement better than CT. In CD, CT is Superior to GS for localization of both active and fibrostenotic bowel disease, and in detection of the abscesses and fistulas. In UC, GS showed proximal extension more accurately than CT.
authors.affiliation: Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Kolkman
authors.forename: T H
authors.initials: TH
authors.lastname: Falke
authors.forename: J C
authors.initials: JC
authors.lastname: Roos
authors.forename: D H
authors.initials: DH
authors.lastname: Van Dijk
authors.forename: I M
authors.initials: IM
authors.lastname: Bannink
authors.forename: W
authors.initials: W
authors.lastname: Den Hollander
authors.forename: M A
authors.initials: MA
authors.lastname: Cuesta
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
authors.forename: S G
authors.initials: SG
authors.lastname: Meuwissen
mesh_terms: D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D003424:Crohn Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006098:Granulocytes; D006801:Humans; D007422:Intestines / Q000473:pathology; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime