Influence of purified apoprotein E on platelet activation induced by serotonin.
Serotonin induces platelet activation. Purified apoprotein E of 300 micrograms/ml prevented morphological alterations of blood platelets stimulated with serotonin (5 microM). Lower concentrated apoprotein E showed no such clear effects. These findings suggest that apoprotein E may liter atherosclerosis by suppressing agonist-induced platelet activation.
Pfennig
O
O
Platelet Research Unit, Institute of Anatomy, University of Münster, Germany.
Zhao
B
B
Dierichs
R
R
D001057:Apolipoproteins E / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D015539:Platelet Activation / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*
D001057:Apolipoproteins E; D012701:Serotonin