Acetogenins from Annonaceae, inhibitors of mitochondrial complex I.
One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).
Zafra-Polo
M C
MC
Departamento de Farmacología (Farmacognosia y Farmacodinamia), Facultad de Farmacia, Universidad de Valencia, Spain.
González
M C
MC
Estornell
E
E
Sahpaz
S
S
Cortes
D
D
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008928:Mitochondria / Q000201:enzymology*; D015394:Molecular Structure; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000037:antagonists & inhibitors*; D010944:Plants; D010946:Plants, Medicinal; D013045:Species Specificity
D004791:Enzyme Inhibitors; D005663:Furans; D016660:NAD(P)H Dehydrogenase (Quinone)