Transcription factors and inflammatory disease.
DNA-binding proteins enable extracellular signals to influence cellular manufacture of substances implicated in chronic inflammation. Cross-talk between the nuclear messenger pathways subserving such regulation accounts for differences among inflammatory diseases. It also explains much of the efficacy of current therapies and may be the basis for novel, more specific approaches to treatment.
Barnes
P J
PJ
National Heart and Lung Institute, London.
D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D014157:Transcription Factors