title: Mobile lipid accumulation in necrotic tissue of high grade astrocytomas.
abstract: Multiple samples from 42 astrocytomas were investigated ex vivo by 1H MR spectroscopy followed by histological assessment. MR visible lipids were detected in 27 of 32 grade 4 astrocytomas. These lipids were heterogeneously distributed within the tumours. Their amount correlated positively with the amount of histologically detected necrosis. Mobile lipids were also observed in grade 4 astrocytoma samples without necrosis, as well as in one of three grade 3, two of three grade 2 and two of four grade 1 astrocytomas. The clinical significance of MR visible lipids, their cellular location, and their possible biological bases are discussed.
authors.affiliation: Institute of Biodiagnostics, NRC, Winnipeg, MB, Canada.
authors.forename: A C
authors.initials: AC
authors.lastname: Kuesel
authors.forename: K M
authors.initials: KM
authors.lastname: Briere
authors.forename: W C
authors.initials: WC
authors.lastname: Halliday
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: S M
authors.initials: SM
authors.lastname: Donnelly
authors.forename: I C
authors.initials: IC
authors.lastname: Smith
mesh_terms: D001254:Astrocytoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy; D009336:Necrosis