title: Disseminated bone marrow metastases of insular thyroid carcinoma detected by radioiodine whole-body scintigraphy.
abstract: We present 131I scintigraphic findings in a patient with insular carcinoma of the thyroid showing diffuse abnormal uptake throughout the skeleton. The scintigraphy closely resembled the pattern of [131I]MIBG distribution in children with bone marrow metastases of neuroblastoma. The extent of involvement was underestimated by bone scintigraphy and radiography. Insular carcinoma of the thyroid in the bone marrow was subsequently demonstrated by biopsy. The patient was treated with 242 mCi 131I given in two courses, which led to severe myelosuppression and died as a result of progressive disease and severe pancytopenia 10 mo after initial therapy.
authors.affiliation: Department of Nuclear Medicine, Sacred Heart Catholic University, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Rufini
authors.forename: M
authors.initials: M
authors.lastname: Salvatori
authors.forename: I
authors.initials: I
authors.lastname: Saletnich
authors.forename: S
authors.initials: S
authors.lastname: Luzi
authors.forename: G
authors.initials: G
authors.lastname: Fadda
authors.forename: B
authors.initials: B
authors.lastname: Shapiro
authors.forename: L
authors.initials: L
authors.lastname: Troncone
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000528:radiation effects; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008875:Middle Aged; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D007457:Iodine Radioisotopes; D013669:Technetium Tc 99m Medronate