[Effects of the antioxidant ionol on humoral immune response in experimental influenza].
The effect of the antioxidant ionol on a humoral immune response was studied in experimental influenza. With preventive introduction of ionol, the affinity of anti-influenza G antibodies circulating in the blood stream was shown to be decreased as compared to that in control animals. The changes in the affinity during influenza infection were cyclic and less marked in the group of animals receiving ionol. The administration of the antioxidant substantially reduced the detection rate of specific blood immune complexes and contributed to the production of antibody-forming cells. The findings suggest that ionol has a favourable effect on a humoral immune response in experimental influenza and alleviates the course of an infectious process.
Meringova
L F
LF
Kramskaia
T A
TA
Dukhin
A I
AI
Iakovleva
I V
IV
Chetverikova
L K
LK
Poliak
R Ia
RIa
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009975:Orthomyxoviridae / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000628:therapy*
D000914:Antibodies, Viral; D000975:Antioxidants; D007074:Immunoglobulin G; D002084:Butylated Hydroxytoluene
Vliianie antioksidanta ionola na gumoral'noe zveno immunogo otveta pri éksperimental'nom grippe.