[Two cases of gram-positive sepsis successfully treated with vancomycin in combination with imipenem or cilastatin].
Against gram-positive sepsis, vancomycin (VCM) was administered in combination with imipenem or cilastatin (IPM/CS). Its excellent efficacy was confirmed in 2 cases, one affected with methicillin resistant Staphylococcus aureus and another with Gemella morbillorum. By calculating the FIC index according to a checkerboard technique, the in vitro synergistic effect was also demonstrated. At the present state multi-drug resistant gram-positive infections prevailed, the combination of VCM with IPM/CS can be expected as an effective measure for treating these diseases.
Sakamoto
M
M
Second Department of Internal Medicine, Jikei University School of Medicine, Japan.
Saruta
K
K
Nakazawa
Y
Y
Shindo
N
N
Maezawa
H
H
Yoshikawa
K
K
Yoshida
M
M
Shiba
K
K
Sakai
O
O
Saitoh
A
A
D000293:Adolescent; D015377:Cilastatin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D008297:Male; D018805:Sepsis / Q000188:drug therapy*; D014640:Vancomycin / Q000627:therapeutic use
D015377:Cilastatin; D014640:Vancomycin; D015378:Imipenem