title: Stenosis and renographic characteristics in renovascular disease.
abstract: This study was designed to determine the degree of renal artery stenosis (RAS) which produces changes in renographic parameters.
  
  
  METHODS
  The angiographic severity of luminal narrowing in RAS was compared to 131I-hippuran renographic characteristics in 72 patients who have been selected for renal angiography because of suspected renovascular hypertension.
  
  
  RESULTS
  Significant differences in Tmax, T1/2 and counts under the curve to Tmax were apparent at 30% of arterial luminal narrowing when stenotic and nonstenotic kidneys were compared. In patients with unilateral RAS, the difference in counts under the Tmax curve between pairs of kidneys was also significantly different at 30% of stenosis. Patients with bilateral stenosis, on the other hand, could not be differentiated well from patients with essential hypertension because the Tmax value on either side or the difference of Tmax between the two kidneys and the values of the other parameters were similar, except for the difference in counts to Tmax. Based on these findings it seems that bilateral RAS does not "mimic" unilateral stenosis in renographic terms, but rather, resembles a normal situation.
  
  
  CONCLUSIONS
  Significant renographic changes can occur at 30% of arterial luminal narrowing in renal artery disease.
authors.affiliation: Department of Internal Medicine, University Hospital, Maastricht, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Schreij
authors.forename: G H
authors.initials: GH
authors.lastname: Ritsema
authors.forename: G
authors.initials: G
authors.lastname: Vreugdenhil
authors.forename: P W
authors.initials: PW
authors.lastname: de Leeuw
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D012077:Renal Artery / Q000000981:diagnostic imaging; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity
chemical_list: D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid