title: The effect of pre-incisional infiltration with lignocaine on postoperative pain after molar teeth extraction under general anaesthesia.
abstract: In a double-blind, placebo-controlled investigation, we studied the effects of pre-operative inferior alveolar nerve blockade and local anaesthetic intra-oral infiltration upon postoperative pain following third molar teeth extraction under general anaesthesia. Thirty six patients (12 male), mean (range) age 25.7 (18-40) years received an injection of 2% lignocaine 2 ml with 1:200,000 adrenaline around the inferior alveolar nerve and tissues adjacent to the third molar tooth on one side and of normal saline 2 ml in a similar fashion to the other side. We measured the pain on each side of the mandible on the 1st, 4th and 11th days after surgery using a visual analogue scale. The visual analogue pain score on the lignocaine and saline sides were 25/100 and 26/100 on day 1, 23/100 and 22/100 on day 4 and 0/100 and 1/100 on day 11. This study has a power of 80% to detect differences at the 5% level of significance of 11/100 on days 1 and 4 and 7/100 on day 11. We found no significant difference in the visual analogue scores between the lignocaine side and the saline side at any stage after the procedure.
authors.affiliation: Northampton General Hospital.
authors.forename: S G
authors.initials: SG
authors.lastname: Tordoff
authors.forename: M
authors.initials: M
authors.lastname: Brossy
authors.forename: D J
authors.initials: DJ
authors.lastname: Rowbotham
authors.forename: J N
authors.initials: JN
authors.lastname: James
authors.forename: R
authors.initials: R
authors.lastname: James
authors.forename: J H
authors.initials: JH
authors.lastname: Raphael
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D000779:Anesthetics, Local; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008012:Lidocaine; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011184:Postoperative Period; D011229:Preanesthetic Medication; D014081:Tooth Extraction
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine