title: Synthesis and cytotoxic activity of peptides containing basic amino acids residues.
abstract: We synthesized eight peptides containing from three to twenty residues of arginine, lysine and histidine, using an automated synthetiser and Fmoc strategy. All peptides were purified by preparative reverse-phase HPLC and characterized by electrospay mass spectometry. Cytotoxic activity was assessed on HeLa cells. One peptide inhibited the colony-forming ability of tumor cells.
authors.affiliation: Dipartamento di Chimica Organica e Industriale dell'Universitá di Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Chillemi
authors.forename: P
authors.initials: P
authors.lastname: Francescato
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: A
authors.initials: A
authors.lastname: Fraccari
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
mesh_terms: D000595:Amino Acid Sequence; D002455:Cell Division / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments