title: Transcranial Doppler in the evaluation of internal carotid artery dissection.
abstract: OBJECTIVE
  A subject with dissection of the internal carotid artery (ICA) may present with a variety of symptoms, from headache to stroke. Thus far, it has not been possible to identify the subset of patients at risk for cerebral ischemia. Because the majority of these ischemic events are secondary to embolic phenomena, we used transcranial Doppler (TCD) evaluation with emboli monitoring to study 17 consecutive patients with ICA dissection treated at Harborview Medical Center, Seattle, Wash, during a 2-year period from 1992 until 1994.
  
  
  METHODS
  Ten patients with ICA dissection secondary to trauma and seven with spontaneous ICA dissection were diagnosed by carotid angiography and studied by TCD from the time of diagnosis through initiation of therapy. Emboli monitoring was performed in the middle cerebral artery (MCA) ipsilateral to the dissection at the initial evaluation and intermittently thereafter to ensure that the emboli stopped with treatment.
  
  
  RESULTS
  Emboli were detected in the MCA distal to the dissection in 10 of 17 patients (59%). Patients with microemboli detected by TCD presented with a stroke (70%) much more frequently than those without emboli (14%) (P=.0498). The presence of a pseudoaneurysm did not increase the risk of either microemboli or stroke.
  
  
  CONCLUSIONS
  We have demonstrated a high incidence of intracranial microemboli in the MCA distal to carotid dissections and a significant correlation between the presence of emboli and stroke. TCD can therefore be used as an adjunctive tool to manage patients with suspected carotid dissection and may prove useful in evaluating the efficacy of treatment in reducing microemboli and subsequent stroke.
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, Seattle, 98104, USA.
authors.forename: J
authors.initials: J
authors.lastname: Srinivasan
authors.forename: D W
authors.initials: DW
authors.lastname: Newell
authors.forename: M
authors.initials: M
authors.lastname: Sturzenegger
authors.forename: M R
authors.initials: MR
authors.lastname: Mayberg
authors.forename: H R
authors.initials: HR
authors.lastname: Winn
mesh_terms: D000293:Adolescent; D000328:Adult; D000784:Aortic Dissection / Q000000981:diagnostic imaging* / Q000209:etiology; D000925:Anticoagulants / Q000627:therapeutic use; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D017585:Ultrasonography, Doppler, Transcranial; D014859:Warfarin / Q000627:therapeutic use; D014861:Washington
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin