title: Malignant bone tumors of childhood.
abstract: Improvements in diagnosis and treatment have increased survival for many children with malignant bone tumors. New molecular genetic discoveries are providing insights into the mechanisms of tumorigenesis and may provide novel therapeutic modalities based on interfering with aberrant transcriptional activation by hybrid transcripts.
authors.affiliation: Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania, USA.
authors.forename: B P
authors.initials: BP
authors.lastname: Himelstein
authors.forename: J P
authors.initials: JP
authors.lastname: Dormans
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D001842:Bone and Bones / Q000473:pathology* / Q000601:surgery; D002648:Child; D004358:Drug Therapy; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology; D009447:Neuroblastoma / Q000175:diagnosis / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D011878:Radiotherapy; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy