[A thermodynamic analysis of oxidative inactivation of influenza virus and lipid peroxidation of viral envelope lipids].
The "activation energy" values for virus inactivation (22.2 kcal/mol) calculated using Arrenius formula and the levels of accumulation of the final product of lipid peroxidation, fluorescent pigment (21.2 kcal/mol), in virus envelopes were found to be in good correlation for purified influenza A/PR8/34 virus suspensions stored at temperatures from 6 to 37 degrees C. A "lipid" mechanism of inactivation of enveloped viruses is proposed, permitting, together with the "nucleic" and "protein" mechanisms, a satisfactory interpretation of the relationship between the stability of viral material and the medium composition, lipid composition of virus envelopes, and other factors.
Poryvaev
V D
VD
D005456:Fluorescent Dyes; D009980:Influenza A virus; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000378:metabolism; D018384:Oxidative Stress; D013816:Thermodynamics; D014759:Viral Envelope Proteins / Q000378:metabolism*
D005456:Fluorescent Dyes; D008563:Membrane Lipids; D014759:Viral Envelope Proteins
Termodinamicheskiĭ analiz okislitel'noĭ inaktivatsii virusa grippa i perekisnogo okisleniia lipidov virusnykh obolochek.