Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica.
Two new quassinoids, bruceanols G [1] and H [4], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation. Bruceanol G exhibited significant cytotoxicity against the COLO-205 and KB neoplastic cell lines with ED50 values of 0.44 and 0.55 microM, respectively.
Imamura
K
K
Department of Interdisciplinary Studies of Natural Environment, Hiroshima University, Higashihiroshima, Japan.
Fukamiya
N
N
Nakamura
M
M
Okano
M
M
Tagahara
K
K
Lee
K H
KH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D004354:Drug Screening Assays, Antitumor; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D036702:Quassins; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D036702:Quassins; C100479:bruceanol G; C100480:bruceanol H; D005900:Glaucarubin