Continuous enteral feeding in uremic rats.
Because of constant uremia-induced anorexia, food restriction of normal rats is generally used to study the consequences of uremia. The effects of a normal food supply in uremic rats has never been tested, since no author has succeeded in providing normal intakes. Uremic rats either fed ad lib (U rats, n = 12) or force-fed through a gastric catheter (UF rats, n = 10), and sham-operated rats (C rats, n = 10) were compared from days 7 to 21 after surgery. U rats had lower food intake (13.8 vs. 17 g/day), weight gain (5.16 vs. 6.23 g/day), length gain (4 vs. 5 mm/day), nitrogen balance (228 vs. 279 mg/day) and muscle fractional protein synthesis rate (9.5 vs. 10.6%) measured in vivo by 3H-phenylalanine injection (p < 0.05 for all). All parameters were restored to normal values in UF rats, possibly due to correction of underhydration in addition to undernutrition. Such continuous enteral feeding may provide a model for normal nutritional supply in uremia.
Maniar
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INSERM U 192, Hôpital Necker-Enfants Malades, Paris, France.
Laouari
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D
Motel
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Kleinknecht
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C
D000818:Animals; D000855:Anorexia / Q000209:etiology; D001639:Bicarbonates / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004750:Enteral Nutrition; D005247:Feeding Behavior; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D010710:Phosphates / Q000097:blood; D014176:Protein Biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood; D014511:Uremia / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D015430:Weight Gain
D001639:Bicarbonates; D001798:Blood Proteins; D010710:Phosphates; D014508:Urea; D012964:Sodium; D003404:Creatinine; D002118:Calcium