title: Spinal MRI in patients with suspected multiple sclerosis and negative brain MRI.
abstract: Although MRI detects the white matter lesions of multiple sclerosis within the brain with high sensitivity, a minority of patients have normal brain MRI. We describe 20 patients, selected from over 170 who had undergone brain imaging with minimal (n = 12) or no (n = 8) abnormalities (median number of lesions = I, range, 0-3) but in whom spinal MRI was abnormal. Twelve had clinically definite or laboratory supported definite multiple sclerosis according to the Poser criteria; one had clinically probable disease and seven, not fulfilling the Poser criteria, were classified as possible multiple sclerosis. All had presented with symptoms and signs referable to the spinal cord or optic nerves. Eleven had a primary progressive course, eight relapsing-remitting and only one secondary progressive. Moderate or severe disability was the rule in the primary progressive cases; all the relapsing-remitting patients had minimal disability. All had at least one lesion visible in the spinal cord (median 2; range 1-6). In patients in whom the diagnosis of multiple sclerosis is not supported by abnormalities on brain MRI, imaging of the spinal cord can be of considerable value.
authors.affiliation: NMR Research Unit, Institute of Neurology, London, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Thorpe
authors.forename: D
authors.initials: D
authors.lastname: Kidd
authors.forename: I F
authors.initials: IF
authors.lastname: Moseley
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: D G
authors.initials: DG
authors.lastname: MacManus
authors.forename: D A
authors.initials: DA
authors.lastname: Compston
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000473:pathology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology; D013118:Spinal Cord Diseases / Q000175:diagnosis* / Q000473:pathology