Metoclopramide and prochlorperazine do not decrease propofol hypnotic requirements.
One hundred patients scheduled for minor surgery were given either saline, metoclopramide 0.1 mg.kg-1 or 0.2 mg.kg-1, or prochlorperazine 0.1 mg.kg-1 or 0.2 mg.kg-1 before induction of anaesthesia with a fixed rate infusion of propofol. Neither metoclopramide nor prochlorperazine reduced the induction dose of propofol. The possibility that these agents increased the induction dose could not be excluded.
Ali
P B
PB
University Department of Anaesthesia, Royal Victoria Infirmary.
Graham
S G
SG
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000932:Antiemetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D011346:Prochlorperazine / Q000494:pharmacology*; D015742:Propofol / Q000008:administration & dosage*
D018686:Anesthetics, Intravenous; D000932:Antiemetics; D008787:Metoclopramide; D011346:Prochlorperazine; D015742:Propofol