title: Adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone.
abstract: A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone is reported. A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adrenal tumor. The plasma level of aldosterone was normal, and the levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were extremely high. After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were normalized. The tumor was benign adenoma and the production of steroid hormones was under control of adrenocorticotropic hormone. The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue.
authors.affiliation: Department of Internal Medicine, Arida Municipal Hospital, Wakayama.
authors.forename: Y
authors.initials: Y
authors.lastname: Toyoda
authors.forename: M
authors.initials: M
authors.lastname: Mizukoshi
authors.forename: M
authors.initials: M
authors.lastname: Umemoto
authors.forename: M
authors.initials: M
authors.lastname: Kuchii
authors.forename: K
authors.initials: K
authors.lastname: Ueyama
authors.forename: S
authors.initials: S
authors.lastname: Tomimoto
authors.forename: A
authors.initials: A
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Shima
authors.forename: I
authors.initials: I
authors.lastname: Nishio
authors.forename: Y
authors.initials: Y
authors.lastname: Masuyama
mesh_terms: D015070:18-Hydroxydesoxycorticosterone / Q000097:blood*; D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000450:Aldosterone / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D008875:Middle Aged; D012083:Renin / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D015070:18-Hydroxydesoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone