title: Neonatal diagnosis of tuberous sclerosis.
abstract: Intracranial tumors are rare in the neonatal period, and generally the most common histological types are astrocytoma, medulloblastoma, choroid plexus papilloma and neuroectodermal tumors. The early diagnosis of these tumors is often very difficult. The authors report a case of a full-term newborn who presented with opisthotonus. A subependymal mass was detected by cerebral ultrasonography, and when the child was 1 month of age depigmentations appeared on the trunk and on the right leg, confirming the suspicion of tuberous sclerosis. At 3 months of age the child suffered infantile spasm with hypsarrhythmia. The developmental delay, the marked progressive neurological deterioration and the daily seizures suggested surgical resection. Histologic studies showed a subependymal giant cell astrocytoma such as typically occurs in tuberous sclerosis.
authors.affiliation: Neonatal Intensive Care Unit, Ospedale Pediatrico, University of Chieti, Italy.
authors.forename: L A
authors.initials: LA
authors.lastname: Ramenghi
authors.forename: A
authors.initials: A
authors.lastname: Verrotti
authors.forename: S
authors.initials: S
authors.lastname: Domizio
authors.forename: C
authors.initials: C
authors.lastname: Di Rocco
authors.forename: G
authors.initials: G
authors.lastname: Morgese
authors.forename: G
authors.initials: G
authors.lastname: Sabatino
mesh_terms: D001921:Brain / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D004453:Echoencephalography; D005910:Glioma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014402:Tuberous Sclerosis / Q000150:complications / Q000000981:diagnostic imaging*