title: Microbiological and serological investigations of oral lesions in Papillon-Lefèvre syndrome.
abstract: Microbiological and serological (enzyme linked immunosorbent assay) investigations were carried out, including karyotyping, on two Asian children with Papillon-Lefèvre syndrome. In case 1, a girl aged four years, the most prevalent putative periodontopathogens were Eikenella corrodens, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia (deciduous dentition) and Bacteroides gracilis, E corrodens and F nucleatum (permanent dentition). In case 2, a boy aged nine years, they were F nucleatum, P intermedia and P loeschii and E corrodens. Serum from case 2 showed a raised specific IgG antibody response to Actinomyces actino-mycetemcomitans serotype b. Thus, a wider range of species than hitherto reported may be associated with Papillon-Lefèvre syndrome, including A actino-mycetemcomitans and F nucleatum.
authors.affiliation: University Dental Hospital of Manchester.
authors.forename: V
authors.initials: V
authors.lastname: Clerehugh
authors.forename: D B
authors.initials: DB
authors.lastname: Drucker
authors.forename: G J
authors.initials: GJ
authors.lastname: Seymour
authors.forename: P S
authors.initials: PS
authors.lastname: Bird
mesh_terms: D000190:Actinomyces / Q000302:isolation & purification*; D001439:Bacteroides / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D016124:Eikenella corrodens / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016967:Fusobacterium nucleatum / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000382:microbiology*; D010214:Papillon-Lefevre Disease / Q000382:microbiology*; D014094:Tooth, Deciduous