[Cyclosporin A in the treatment of Eaton-Lambert myasthenic syndrome].
The Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of he cholinergic neurotransmition at the presinaptic terminal of the neuromuscular junction. Clinically it is characterized by muscular weakness, hyporeflexia and autonomic dysfunction. In this entity thet presence of antibodies against calcium channels impair acetylcholine release. Whe used cyclosporin-A in a patient with LEMS and this resulted in a complete clinical and neurophysiological recovery after four months of therapy.
Yuste Ara
J R
JR
Departamento de Medicina Interna, Universidad de Navarra, Pamplona.
Beloqui Ruiz
O
O
Artieda Gonzalez-Granda
J
J
Herrero Santos
J I
JI
De la Peña Fernandez
A
A
Prieto Valtueña
J
J
D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004576:Electromyography; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015624:Lambert-Eaton Myasthenic Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine
Ciclosporina-A como tratamiento del síndrome miasteniforme de Eaton-Lambert.