Chemical constituents of halophilic facultatively anaerobic bacteria, 1.
Two new nitrotyramine derivatives, 1 and 2, along with five known aromatic compounds, were isolated from the culture broth of a facultatively anaerobic, halophilic bacterium isolated from a sediment from the Great Salt Plains, Alfalfa County, Oklahoma. The structures of the new compounds were determined from spectral data and were confirmed by synthesis from tyramine hydrochloride. Compound 1 showed cytotoxicity against the murine leukemia P-388 cell line (IC50 3 micrograms/ml).
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Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
Schmitz
F J
FJ
Tanner
R S
RS
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001421:Bacteria, Anaerobic / Q000737:chemistry*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009825:Oklahoma; D012988:Soil Microbiology; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; C100481:N-(2-methylpropionyl)-3-nitrotyramine; D014439:Tyramine