Thrombospondin receptor (CD36) expression of human keratinocytes during wound healing in a SCID mouse/human skin repair model.
Using a human skin/severe combined immunodeficient (SCID) chimeric mouse model, we examined the keratinocyte expression of the thrombospondin receptor (CD36) and its ligand thrombospondin-1 (TSP1) in acute uninflamed wounds. Positive suprabasal keratinocyte expression of CD36 was observed as early as 30 minutes after wounding in the adjacent, intact epidermis; it disappeared 4 days later. Keratinocytes of the freshly re-epithelised wounds and those of the surrounding epidermis remained TSP1-negative throughout the whole observation period of 7 days. Our results indicate that CD36-positive keratinocytes, probably in connection with activated, TSP1-positive thrombocytes, may play an important role in the early phase of wound healing.
Simon
M
M
Department of Dermatology, University of Erlangen-Nürnberg, Germany.
Juhász
I
I
Herlyn
M
M
Hunyadi
J
J
D000818:Animals; D018955:CD36 Antigens / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000276:immunology* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D016513:Mice, SCID; D008954:Models, Biological; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D019699:Thrombospondins; D014945:Wound Healing
D018955:CD36 Antigens; D008562:Membrane Glycoproteins; D019699:Thrombospondins