Inhibition of aldose reductase by maesanin and related p-benzoquinone derivatives and effects on other enzymes.
A naturally occurring p-benzoquinone derivative, maesanin, inhibited porcine lens aldose reductase. Systematic investigation of related p-benzoquinone derivatives revealed that 2,5-dihydroxy-p-benzoquinone was a potent inhibitor of aldose reductase and aldehyde reductase but had no effect on NADH oxidase. Kinetic analysis showed this p-benzoquinone exhibited uncompetitive inhibition against DL-glyceraldehyde and noncompetitive inhibition against NADPH.
Haraguchi
H
H
Faculty of Engineering, Fukuyama University, Japan.
Ohmi
I
I
Kubo
I
I
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D016227:Benzoquinones / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009097:Multienzyme Complexes / Q000187:drug effects; D009247:NADH, NADPH Oxidoreductases / Q000187:drug effects; D013329:Structure-Activity Relationship; D013552:Swine
D016227:Benzoquinones; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; C004532:quinone; C064887:maesanin; D000449:Aldehyde Reductase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases