title: [Systemic mastocytosis as a cause of osteoporosis].
abstract: Out of 21 male patients with osteoporosis who visited an outpatient clinic for endocrine diseases in two years (1994-1995), three had systemic mastocytosis as diagnosed histopathologically. Two of these had characteristic features of urticaria pigmentosa, consisting of multiple brown nodules on the skin of trunk and extremities, and a positive Darier sign. In all of them the excretion of the histamine metabolites methylhistamine and methylimidazoleacetic acid in a 24-hour urine specimen was increased. When osteoporosis is diagnosed in men or premenopausal women, underlying pathology could be considered. Cautious investigation of signs and symptoms of systemic mastocytosis in such patients might prove this disease be less rare than is often assumed.
authors.affiliation: Academisch Ziekenhuis, afd. Endocriene Ziekten, Nijmegen.
authors.forename: S A
authors.initials: SA
authors.lastname: Kemink
authors.forename: A G
authors.initials: AG
authors.lastname: Smals
authors.forename: P W
authors.initials: PW
authors.lastname: Kloppenborg
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D002119:Calcium Carbonate / Q000627:therapeutic use; D012968:Etidronic Acid / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000652:urine; D008297:Male; D008415:Mastocytosis / Q000150:complications*; D008761:Methylhistamines / Q000652:urine; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014582:Urticaria Pigmentosa / Q000150:complications
chemical_list: D007093:Imidazoles; D008761:Methylhistamines; C002667:methylimidazoleacetic acid; D002119:Calcium Carbonate; D012968:Etidronic Acid
vernacular_title: Systemische mastocytose als oorzaak van osteoporose.