[The initiation of normal follicular growth and in imbalance of the stromal and follicular components of the ovary in the mouse].
Cyclophosphamide administration to pregnant mice results in germ cells reduction in their progeny. Dynamics of follicular growth initiation was studied in these conditions. Results of the investigation confirmed the presence of dependence between the level of follicular growth and the size of the quiescent pool. This dependence was found to be non-linear-two threshold areas of values for the germ cell number with the changing dependence were discovered. The contribution of growing follicles tends to increase as the entire germinative population reduces in size. Increase of the share of growing follicles correlates with the increase of the ovarian stroma relative volume. This allows to suggest the possibility of participation of the latter in the regulation of follicular growth initiation.
Petropavlovskaia
M S
MS
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D051379:Mice; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D011247:Pregnancy; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide
Initsiatsiia rosta follikulov v norme i pri disbalanse stromal'nogo i follikuliarnogo komponentov iaichnika myshi.