Atypical MRI findings in treatment-related leukoencephalopathy: case report.
A patient with acute myeloblastic leukaemia showed atypical findings on MRI following combination therapy including intrathecal methotrexate and radiation. MRI findings not previously been reported are ring as well as patchy enhancement, marked mass effect and lesions extending to the putamen and corpus callosum.
Ohmoto
Y
Y
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.
Kajiwara
K
K
Kato
S
S
Nisizaki
T
T
Ito
H
H
Tamura
S
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D003131:Combined Modality Therapy; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology; D016371:Cranial Irradiation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009186:Myelin Sheath / Q000187:drug effects / Q000473:pathology; D011699:Putamen / Q000187:drug effects / Q000473:pathology
D008727:Methotrexate