Role and modulation of T-cell cytokines in allergy.
Allergic sensitization and the development of effector functions are controlled by IL-4-secreting and IL-5-secreting type 2 T cells. Recent studies have provided new insights into the events triggering the development of type 1 and type 2 T cells, the discrimination of type 1 and type 2 effector T cells from various T-cell subsets, and the improvement of established and new therapeutic strategies, which are aimed at modulating such T-cell functions in the allergic patient.
Daser
A
A
Virchow Klinikum of the Humboldt University, Berlin, Germany.
Meissner
N
N
Herz
U
U
Renz
H
H
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000485:Allergens / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology* / Q000628:therapy; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D013256:Steroids; D016176:T-Lymphocyte Subsets / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism*
D000276:Adjuvants, Immunologic; D000485:Allergens; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D013256:Steroids; D016753:Interleukin-10; D015847:Interleukin-4; D007073:Immunoglobulin E