Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene.
The oxytocin receptor (OTR), a member of the seven-transmembrane domain guanine-nucleotide-binding protein (G protein) coupled receptor family plays a central role in lactation, ovarian cyclicity and reproductive behaviour. Recent cloning and sequencing unexpectedly revealed that the third intracytoplasmic region (3ICR) of the sheep receptor has 3 and 2 additional amino acids (aa) relative to the rat and human receptors, respectively. We have now confirmed, by sequencing polymerase chain reaction (PCR)-derived genomic fragments coding for the OTR 3ICR from a variety of ruminant and non-ruminant species, that additional aa are a general phenomenon in ruminants.
Kaluz
S
S
University of Nottingham, Loughborough, UK. sbzsk@sbn3.nott.AC.UK
Kaluzova
M
M
Flint
A P
AP
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018740:Genetic Heterogeneity; D006801:Humans; D008969:Molecular Sequence Data; D018045:Receptors, Oxytocin / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012756:Sheep
D018045:Receptors, Oxytocin