Mercury distribution and renal metallothionein induction after subchronic oral exposure in rats.
The effects of long-term daily intake of low and high levels of mercury on its organ distribution and binding to renal metallothionein (MT) in male rats were studied. The animals were exposed to mercuric chloride labelled with 203Hg via drinking water for 8 weeks (5, 50 and 500 microM Hg). The greatest concentration of mercury was found in the kidneys. Similar levels of radioactivity in the buccal cavity and oesophagus were also observed by whole-body autoradiography. In the kidneys, the mercury was accumulated in the outer stripe of the outer zone of the medulla and, to a minor degree, in the renal cortex. Almost 50% the total renal mercury was associated to MT. The binding capacity of the renal MT for mercury tends to saturate with increasing doses, thus this means that the capacity of the kidneys to accumulate mercury is limited.
Morcillo
M A
MA
División de Isótopos, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.
Santamaria
J
J
D000284:Administration, Oral; D000818:Animals; D004334:Drug Administration Schedule; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008628:Mercury / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D008668:Metallothionein / Q000096:biosynthesis* / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D008668:Metallothionein; D008628:Mercury