Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons.
The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.
Mahalingam
R
R
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.
Wellish
M
M
Cohrs
R
R
Debrus
S
S
Piette
J
J
Rentier
B
B
Gilden
D H
DH
D000328:Adult; D005728:Ganglia, Sympathetic / Q000382:microbiology*; D014645:Herpesvirus 3, Human / Q000378:metabolism*; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D007223:Infant; D015534:Trans-Activators / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014759:Viral Envelope Proteins / Q000378:metabolism*; D017735:Virus Latency
C074221:IE62 protein, Human herpesvirus 3; D017874:Immediate-Early Proteins; D015534:Trans-Activators; D014759:Viral Envelope Proteins