title: Augmentation cystoplasty using pedicled and de-epithelialized gastric patches in the mini-pig model.
abstract: OBJECTIVE
  The most common methods of bladder augmentation are gastrocystoplasty and enterocystoplasty. Gastrocystoplasty is advantageous due to minimal mucous secretion and a well developed muscular wall as well as good urodynamic properties of the patch. However, the permanent contact of urine with the gastric mucosa is not free of complications. We report the urodynamic, macroscopic and histological outcomes of a pedicled de-epithelialized gastric patch incorporated in the bladder. We compared the results to those of our previous study, which sought to analyze these techniques of patch coverage using sigmoid patches.
  
  
  METHODS
  We performed 20 augmentation cystoplasties in the mini-pig model using a pedicled de-epithelialized gastric patch and 5 techniques of patch coverage.
  
  
  RESULTS
  Three months after surgery all bladders had an increase in volume except those in which the auto-augmentation technique was used. However, all gastric patches were smaller compared to preoperative size. Many had irregular fibrosed inner surfaces and histological evaluation revealed a fibrosed newly formed submucosal layer with a complete urothelial coverage in every patch. No gastric mucosal remnant was found.
  
  
  CONCLUSIONS
  De-epithelialized gastrocystoplasty is an attractive procedure that can increase bladder capacity as well as provide a complete urothelial lining without mucosal remnants. However, the success of this procedure seems to be limited by increased morbidity and fibrotic changes, and decreased surface of the patch.
authors.affiliation: Department of Pediatric Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Frey
authors.forename: N
authors.initials: N
authors.lastname: Lutz
authors.forename: A L
authors.initials: AL
authors.lastname: Leuba
mesh_terms: D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000637:transplantation*; D013552:Swine; D013556:Swine, Miniature; D001743:Urinary Bladder / Q000033:anatomy & histology / Q000601:surgery*