title: Antiamoebic activity of Piper longum fruits against Entamoeba histolytica in vitro and in vivo.
abstract: The fruits of Piper longum used in traditional remedies against intestinal distress have been tested for their efficacy against experimental caecal amoebiasis of rats. The ethanolic extract, hexane fraction, n-butanol soluble fraction exerted in vitro amoebicidal action at 1000 micrograms/mL and the chloroform fraction at 500 micrograms/mL. The ethanolic extract and piperine, a pure compound, from this plant material cured 90% and 40% of rats with caecal amoebiasis, respectively.
authors.affiliation: Division of Microbiology, Central Drug Research Institute, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Ghoshal
authors.forename: B N
authors.initials: BN
authors.lastname: Prasad
authors.forename: V
authors.initials: V
authors.lastname: Lakshmi
mesh_terms: D000470:Alkaloids; D000562:Amebiasis / Q000188:drug therapy*; D000818:Animals; D052117:Benzodioxoles; D065607:Cytochrome P-450 Enzyme Inhibitors; D004747:Entamoeba / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit; D006801:Humans; D008519:Medicine, Traditional; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides; D051381:Rats; D013810:Therapeutic Equivalency
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; C008922:piperine