Hydroxymycotrienins A and B, new ansamycin group antibiotics.
New ansamycins designated hydroxymycotrienins A and B were isolated from culture broths of Bacillus sp. BMJ958-62F4. The two antibiotics inhibited more strongly the growth of human cervical cancer cell lines of human papilloma virus (HPV) positive than that of HPV negative cell lines. The structures, some biological and biochemical properties are reported.
Hosokawa
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Naganawa
H
H
Hamada
M
M
Takeuchi
T
T
Ikeno
S
S
Hori
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001407:Bacillus; D001483:Base Sequence; D005260:Female; D005285:Fermentation; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D017828:Rifabutin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D000900:Anti-Bacterial Agents; C100398:hydroxymycotrienin A; C100399:hydroxymycotrienin B; D017828:Rifabutin