title: T-cell lymphoma presenting with pericardial and pleural effusion as the initial and primary lesion: cytogenetic and molecular evidence.
abstract: A 90-year-old woman was admitted with progressive dyspnea. Chest roentgenogram and computed tomography revealed a massive pericardial effusion and bilateral pleural effusion, but no lymphomatous lesion was seen. A diagnosis of malignant lymphoma was made by cytological and immunological studies of the cells obtained from the pericardial effusion. Chromosome analysis showed a clonal abnormality and T-lineage clonality was determined by the rearrangement of the T-cell receptor gamma gene. The patient achieved remission with chemotherapy, but she later relapsed, with right pleural effusion, and died. She exhibited no lymphomatous features throughout the clinical course, indicating the possibility of malignant lymphoma originating from the pericardium and/or pleura.
authors.affiliation: Internal Medicine, Saiseikai Kyoto Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
authors.forename: M
authors.initials: M
authors.lastname: Nakao
authors.forename: H
authors.initials: H
authors.lastname: Kanemasa
authors.forename: T
authors.initials: T
authors.lastname: Ueha
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Fujino
authors.forename: T
authors.initials: T
authors.lastname: Oishi
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
authors.forename: H
authors.initials: H
authors.lastname: Tanigawa
authors.forename: S
authors.initials: S
authors.lastname: Horiike
authors.forename: S
authors.initials: S
authors.lastname: Yokota
authors.forename: S
authors.initials: S
authors.lastname: Misawa
authors.forename: K
authors.initials: K
authors.lastname: Kashima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D004273:DNA, Neoplasm / Q000032:analysis; D004452:Echocardiography; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000235:genetics; D010490:Pericardial Effusion / Q000175:diagnosis* / Q000235:genetics; D010996:Pleural Effusion / Q000175:diagnosis* / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D014057:Tomography, X-Ray Computed
chemical_list: D004273:DNA, Neoplasm; D016692:Receptors, Antigen, T-Cell, gamma-delta