Fatal Cytomegalovirus pneumonia in a patient receiving corticosteroids and methotrexate for mixed connective tissue disease.
Cytomegalovirus (CMV) pneumonia is a serious illness that may occur in severely immunocompromised patients such as those with bone marrow transplants. A strong association between this condition and immunosuppressive therapy for collagen vascular diseases has not been described. We describe a patient who had CMV pneumonia while receiving methotrexate and corticosteroids for mixed connective tissue disease.
Wallace
J R
JR
Division of Infectious Diseases, University of Kansas Medical Center, Kansas City 66160-7354, USA.
Luchi
M
M
D000328:Adult; D003586:Cytomegalovirus Infections / Q000209:etiology*; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy*; D011024:Pneumonia, Viral / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate