title: Recent progress in advanced glycation and diabetic vascular disease: role of advanced glycation end product receptors.
abstract: Advanced glycosylation end products (AGEs) form principally from the rearrangement of early glycation products, i.e., Amadori products, which produce a class of stable moieties that possess distinctive chemical crosslinking and biological properties. It has been generally believed that proteins with half-lives of longer than a few weeks are most susceptible to advanced glycosylation and that the highest levels of AGEs occur on proteins that comprise the long-lived structural components of connective tissue matrix and basement membrane.
authors.affiliation: Picower Institute for Medical Research, Manhasset, New York 10030, USA.
authors.forename: H
authors.initials: H
authors.lastname: Vlassara
authors.forename: R
authors.initials: R
authors.lastname: Bucala
mesh_terms: D000818:Animals; D003925:Diabetic Angiopathies / Q000209:etiology*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic