title: [Does the administration of a high dose of a paramagnetic contrast medium (Gadovist) improve the diagnostic value of magnetic resonance tomography in glioblastomas?].
abstract: OBJECTIVE
  To assess the efficacy of high-dose contrast enhanced magnetic resonance imaging (MRI) in detection and delineation of infiltrating tumour in glioblastoma.
  
  
  METHODS
  In a phase II clinical trial 14 patients with suspected supratentorial glioblastoma underwent MRI with Gd-DO3A-butriol (Gadovist, Schering AG, Berlin) with doses of 0.1 up to 0.3 mmol/kg.
  
  
  RESULTS
  Increasing the dose of Gd-DO3A-butriol resulted in improved enhancement (14/14) and better delineation of infiltrating tumour (9/14) up to 2 cm beyond enhancement after standard dose. In two of the 9 patients additional enhancement in the peritumoural oedema was only seen after the third injection.
  
  
  CONCLUSIONS
  Successful surgery requires precise preoperative delineation of tumour borders. After high-dose MRI it might be possible to select those patients who would benefit from more radical attempts at eradicating the macroscopic as well as most of the microscopic compartment of glioblastoma.
authors.affiliation: Abteilung Klinische Neuroradiologie, Ruprecht-Karls-Universität, Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
authors.forename: M
authors.initials: M
authors.lastname: Forsting
authors.forename: O
authors.initials: O
authors.lastname: Jansen
authors.forename: F K
authors.initials: FK
authors.lastname: Albert
authors.forename: T
authors.initials: T
authors.lastname: Balzer
authors.forename: K
authors.initials: K
authors.lastname: Sartor
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D011446:Prospective Studies; D015173:Supratentorial Neoplasms / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; D005682:Gadolinium
vernacular_title: Verbessert die Hochdosisgabe eines paramagnetischen Kontrastmittels (Gadovist) die diagnostische Aussage der Magnetresonanztomographie bei Glioblastomen?