title: Apolipoprotein B levels and related factors in a rural white South African community--the CORIS study. Coronary Risk Factor Study.
abstract: OBJECTIVE
  In a survey of the Coronary Risk Factor Study (CORIS), apolipoprotein B (apoB) levels were determined to ascertain their impact on coronary heart disease (CHD) risk. Other CHD risk factors associated with apoB were also identified.
  
  
  METHODS
  Cross-sectional analytical study, which included CHD risk factor and dietary questionnaires, electrocardiography, anthropometric and blood pressure measurements, and a blood sample for a lipid profile.
  
  
  METHODS
  The three districts of Riversdale, Robertson and Swellendam in the south-western Cape; a 25% random sample of 1,528 white respondents aged 15-68 years.
  
  
  RESULTS
  Men tended to have higher mean apoB levels than women. Classification of CHD risk by apoB levels and total cholesterol (TC) levels did not correspond, as only 61% of men and 58.5% of women were classified in the same risk categories. Respondents in the highest apoB risk category reported a medical history of hypercholesterolaemia and hypertension more frequently than those in lower categories. There was a significant increase from the low to the high apoB risk category of TC, low-density lipoprotein (LDL) cholesterol, triglyceride levels, body mass index and percentage body fat. Using stepwise multiple regression, 84.9% of the variation in apoB of men and 85.8% in apoB of women were accounted for by significantly associated variables.
  
  
  CONCLUSIONS
  Although apoB may be a better predictor of CHD than TC or LDL cholesterol concentrations, its easy approximation with the formula (TC-HDLC)/2 + 20, high cost, measurement variability and an approach in management similar to that for raised TC discourage its routine use in the screening of patients for CHD.
authors.affiliation: Chronic Diseases of Lifestyle Programme, Medical Research Council, Parowvallel, W. Cape.
authors.forename: K
authors.initials: K
authors.lastname: Steyn
authors.forename: J E
authors.initials: JE
authors.lastname: Rossouw
authors.forename: M J
authors.initials: MJ
authors.lastname: Weight
authors.forename: J M
authors.initials: JM
authors.lastname: Fourie
authors.forename: A J
authors.initials: AJ
authors.lastname: Benadé
authors.forename: P L
authors.initials: PL
authors.lastname: Jooste
authors.forename: D O
authors.initials: DO
authors.lastname: Chalton
authors.forename: P
authors.initials: P
authors.lastname: Wolmarans
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001055:Apolipoproteins B / Q000097:blood*; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D003430:Cross-Sectional Studies; D004034:Diet Surveys; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012424:Rural Population; D013019:South Africa; D014280:Triglycerides / Q000097:blood; D044465:White People
chemical_list: D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol