title: Another case of t(17;22)(q22;q13) in an infantile dermatofibrosarcoma protuberans.
abstract: We have identified a new dermatofibrosarcoma protuberans (DP) case with a t(17;22) (q22;q13) occurring in a child. The translocation was substantiated by the presence of one or two copies of the sole der(22)t(17;22). This rearrangement added to two normal chromosomes 17 and one or two chromosomes 22, resulted in trisomy 22cen-q13 and trisomy (or tetrasomy) 17q22-25. This observation confirms the specificity of the association of DP with the t(17;22) found together with extra copies of the der(22)t(17;22). It also points out a possible prevalence of translocation rather than rings in DP of the childhood disease.
authors.affiliation: Laboratoire de Génétique Moléculaire des Cancers Humains, URA CNRS 1462, Université de Nice-Sophia Antipolis, France.
authors.forename: F
authors.initials: F
authors.lastname: Pedeutour
authors.forename: J P
authors.initials: JP
authors.lastname: Lacour
authors.forename: C
authors.initials: C
authors.lastname: Perrin
authors.forename: K
authors.initials: K
authors.lastname: Huffermann
authors.forename: M P
authors.initials: MP
authors.lastname: Simon
authors.forename: N
authors.initials: N
authors.lastname: Ayraud
authors.forename: C
authors.initials: C
authors.lastname: Turc-Carel
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D002648:Child; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D018223:Dermatofibrosarcoma / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007621:Karyotyping; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D018952:Antigens, CD34