title: [Therapy-induced changes in osteosarcoma after neoadjuvant chemotherapy (COSS 86 Therapy Study). Correlation between morphologic findings and clinical follow-up].
abstract: 207 osteosarcomas were examined morphologically after neoadjuvant chemotherapy according to the COSS-86 protocol using representative slides of one whole tumor plane. The rate of responders 63%. In relapse-free patients both the whole tumors and the vital areas there of were smaller than in patients with relapse during a follow-up period of 5 years. Within the subgroup of osteoblastic osteosarcomas, metastases were observed following smaller tumors than in chondroblastic osteosarcomas. Therefore, in addition to degree of regression, histological subtype and tumor size should be considered in the prognostic evaluation of osteosarcomas.
authors.affiliation: Abteilung für Osteopathologie, Institut für Pathologie der Universität, Hamburg.
authors.forename: M
authors.initials: M
authors.lastname: Werner
authors.forename: N
authors.initials: N
authors.lastname: Fuchs
authors.forename: M
authors.initials: M
authors.lastname: Salzer-Kuntschik
authors.forename: K
authors.initials: K
authors.lastname: Winkler
authors.forename: G
authors.initials: G
authors.lastname: Delling
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D011788:Quality of Life; D016896:Treatment Outcome
vernacular_title: Therapie-induzierte Veränderungen an Osteosarkomen nach neoadjuvanter Chemotherapie (Therapiestudie COSS 86). Beziehungen zwischen morphologischen Befunden und klinischem Verlauf.