title: Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer.
abstract: OBJECTIVE
  The purpose of this study was to retrospectively compare different approaches including neoadjuvant chemotherapy.
  
  
  METHODS
  Ninety-six consecutive patients with pyriform sinus squamous cell carcinoma with no distant metastases were entered. The first 48 patients were treated with surgery plus postoperative radiation therapy (50-60 Gy) over cervical lymphatics. The next 48 patients were treated by induction chemotherapy with two courses of cisplatin, 120 mg/m2 i.v. day one, plus bleomycin, 20 mg/m2/day for 5 consecutive days in 24-hr i.v. perfusion followed by definitive surgery and postoperative radiation therapy as in the first therapeutic group.
  
  
  RESULTS
  Definitive surgery was performed in 38 control vs 39 neoadjuvant patients. Complete response was observed in 9 (18.7%) and partial response in 32 (66.7%) of 48 chemotherapy-treated patients. Partial plus complete response was seen in 41 (85.4%) of the 48 patients. Comparison between controls versus chemotherapy-treated groups showed persistence of the disease in 10 vs 9 patients; local-regional relapses in 21 versus 14 patients; and distant metastases in 4 vs 2 patients. Median survival was 12 vs 40 months. Survival curves were statistically better in neoadjuvants than in controls (P < 0.025).
  
  
  CONCLUSIONS
  Multidisciplinary therapy slightly decreases the rate of local-regional relapses and distant metastases and should improve survival in this set of pyriform sinus cancer patients.
authors.affiliation: Department of Medical Oncology, Hospital Clinic, University of Barcelona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Grau
authors.forename: A
authors.initials: A
authors.lastname: Cuchi
authors.forename: J
authors.initials: J
authors.lastname: Estapé
authors.forename: C
authors.initials: C
authors.lastname: Arias
authors.forename: J M
authors.initials: JM
authors.lastname: Mañé
authors.forename: J L
authors.initials: JL
authors.lastname: Fírvida
authors.forename: F
authors.initials: F
authors.lastname: Moreno
authors.forename: J
authors.initials: J
authors.lastname: Traserra
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D001761:Bleomycin; D002945:Cisplatin