[Experimental studies evaluating oncogenic effects of copper-nickel sulfide ore dust].
The experiments on animals studied mutagenic activity of copper-nickel sulfide ore dust. Micronucleus test proved mild mutagenic activity of the ore under study. Chronic inhalation of the dust induced malignancies (mostly lung tumors and leukoses) in 52% of the experimental Wistar rats, that could be caused by dissolution of the dust components in the body fluids.
Borisenkova
R V
RV
Pylev
L N
LN
Lutsenko
L A
LA
Lipatov
G Ia
GIa
Beresneva
O Iu
OIu
Gvozdeva
L L
LL
D000818:Animals; D003300:Copper / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004391:Dust / Q000009:adverse effects; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009532:Nickel / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D004391:Dust; D003300:Copper; D009532:Nickel; C017558:nickel sulfide
Eksperimental'nye issledovaniia po otsenke onkogennogo deĭstviia pyli medno-nikelevoĭ sul'fidnoĭ rudy.