Slow injection of prostaglandin E1 decreases associated penile pain.
OBJECTIVE
A randomized, double-blind study to determine whether speed of intracavernous injection of prostaglandin E1 (PGE1) is associated with pain.


METHODS
On two separate occasions, using two different speeds of injection (5 versus 60 seconds), 11 subjects received the same dose of PGE1 that they used at home. The presence, duration, and intensity of pain were recorded.


RESULTS
We found that fast penile injection of PGE1 was associated with a greater intensity of pain (P = 0.04).


CONCLUSIONS
Slow injection of PGE1 is less often associated with penile pain, the most common adverse effect of this treatment.
Gheorghiu
D
D
Division of Geriatrics Medicine, Medical College of Virginia, Richmond, USA.
Godschalk
M
M
Gheorghiu
S
S
Mulligan
T
T
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement; D011446:Prospective Studies; D013997:Time Factors
D000527:Alprostadil