Evaluation of iohexol as a marker for the clinical measurement of glomerular filtration rate in dogs.
The contrast medium iohexol can be used as a marker for the measurement of glomerular filtration rate. It has the advantages of sample stability and the availability of a simple, automated (though expensive) analyser. The clearance of iohexol was compared with the clearance of Tc-DTPA in 24 dogs with known or suspected renal impairment. The results were comparable but fractionally lower with iohexol. The correction factors developed for human beings were found to be satisfactory in the dogs, thus validating the software routines used in the automated analyser with the canine samples.
Gleadhill
A
A
Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, University of London, North Mymms, Hatfield, Hertfordshire.
Michell
A R
AR
D000818:Animals; D001331:Automation; D003287:Contrast Media; D004283:Dog Diseases; D004285:Dogs; D005919:Glomerular Filtration Rate; D006801:Humans; D007472:Iohexol / Q000493:pharmacokinetics; D007674:Kidney Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D008657:Metabolic Clearance Rate; D012044:Regression Analysis; D015203:Reproducibility of Results; D012984:Software; D016284:Technetium Tc 99m Pentetate
D003287:Contrast Media; D007472:Iohexol; D016284:Technetium Tc 99m Pentetate