[Studies of the radiation-protective effects of indralin on the hematopoietic system of different species of animals].
The experiments were made on mice, guinea pigs and dogs. Radioprotector indraline increased radioresistant state of hematopoietic stem cells in vivo and in vitro, decreased the amount of post-radiation chromosome aberrations in marrow, induced more early and intensive post-radiation proliferative repair of marrow and spleen, faster regeneration of the initial amount of leukocytes, thrombocytes and erythrocytes in blood of mice, guinea pigs and dogs. Antiradiation efficiency of indraline in hematopoietic system is equal to 1.5-2 by FMD. Radioprotective mechanism of indraline effect on hematopoietic system is discussed.
Vasin
M V
MV
Antipov
V V
VV
Chernov
G A
GA
L'vova
T S
TS
Koroleva
L V
LV
Semenova
L A
LA
Liutykh
V P
VP
Komarova
S N
SN
Gaĭdamakin
N A
NA
Vilkina
G A
GA
D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004285:Dogs; D006168:Guinea Pigs; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D006413:Hematopoietic System / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010636:Phenols / Q000494:pharmacology*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012038:Regeneration; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors
D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin
Issledovanie radiozashchitnogo éffekta indralina na krovetvornoĭ sisteme u razlichnykh vidov zhivotnykh.