title: [The possible mechanisms of a fibrinolytic disorder in patients with severe craniocerebral trauma].
abstract: Fibrinolysis components were studied in 32 patients with slight and 38 ones with grave craniocerebral injuries on days 1, 3, 5, and 7 after the injury. No expressed disorders of blood fibrinolytic activity were revealed in patients with slight injuries. Grave craniocerebral injuries were associated with disorders of the plasmin system. Depression of the external and internal mechanisms of fibrinolysis were the most manifest starting from day 3 and caused by a number of factors characteristic of the developing disseminated intravascular blood coagulation syndrome and, possibly, by impaired regulation of the plasmin system by the central nervous system.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Churliaev
authors.forename: V G
authors.initials: VG
authors.lastname: Lychev
authors.forename: A A
authors.initials: AA
authors.lastname: Pavlenko
authors.forename: N N
authors.initials: NN
authors.lastname: Epifantseva
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Chepizhko
authors.forename: V M
authors.initials: VM
authors.lastname: Kovalenko
authors.forename: L G
authors.initials: LG
authors.lastname: Karagaeva
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data; D001930:Brain Injuries / Q000097:blood / Q000150:complications*; D005342:Fibrinolysis; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
vernacular_title: O vozmozhnykh mekhanizmakh narusheniia fibrinoliza u bol'nykh s tiazheloĭ cherepno-mozgovoĭ travmoĭ.