title: [Two cases of gram-positive sepsis successfully treated with vancomycin in combination with imipenem or cilastatin].
abstract: Against gram-positive sepsis, vancomycin (VCM) was administered in combination with imipenem or cilastatin (IPM/CS). Its excellent efficacy was confirmed in 2 cases, one affected with methicillin resistant Staphylococcus aureus and another with Gemella morbillorum. By calculating the FIC index according to a checkerboard technique, the in vitro synergistic effect was also demonstrated. At the present state multi-drug resistant gram-positive infections prevailed, the combination of VCM with IPM/CS can be expected as an effective measure for treating these diseases.
authors.affiliation: Second Department of Internal Medicine, Jikei University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Saruta
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: N
authors.initials: N
authors.lastname: Shindo
authors.forename: H
authors.initials: H
authors.lastname: Maezawa
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Shiba
authors.forename: O
authors.initials: O
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Saitoh
mesh_terms: D000293:Adolescent; D015377:Cilastatin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D008297:Male; D018805:Sepsis / Q000188:drug therapy*; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D015377:Cilastatin; D014640:Vancomycin; D015378:Imipenem