title: Pharmacokinetics of tablet huperzine A in six volunteers.
abstract: OBJECTIVE
  To study pharmacokinetics of tablet huperzine A (Hup-A) in Chinese volunteers to help establishing its drug administration schedule.
  
  
  METHODS
  For 6 volunteers after a single oral dose of 0.99 mg, drug concentrations in plasma were assayed by reverse phase high pressure liquid chromatography (HPLC) at 0.5, 0.75, 1.0, 1.25, 1.5, 2, 4, 6, 8, and 10 h. The pharmacokinetic parameters were calculated with a 3P87 program by computer.
  
  
  RESULTS
  The time course of plasma concentrations conformed to a one-compartment open model with a first order absorption. The pharmacokinetic parameters were as follows: T 1/2ka = 12.6 min, T 1/2ke = 288.5 min, Tmax = 79.6 min, Cmax = 8.4 micrograms L-1, AUC = 4.1 mg L-1 min.
  
  
  CONCLUSIONS
  Hup-A was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate.
authors.affiliation: Department of Pharmacology, Zhejiang Academy of Medical Sciences, Hangzhou, China.
authors.forename: B C
authors.initials: BC
authors.lastname: Qian
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: Z F
authors.initials: ZF
authors.lastname: Zhou
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: R R
authors.initials: RR
authors.lastname: Zhou
authors.forename: G S
authors.initials: GS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000470:Alkaloids; D002800:Cholinesterase Inhibitors / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D012717:Sesquiterpenes / Q000493:pharmacokinetics*; D013607:Tablets
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; D013607:Tablets; C050426:huperzine A