title: Mycobacterium chelonae infection following a total knee arthroplasty.
abstract: Infection following total knee arthroplasty is a major cause of implant failure, with an incidence of infections between 1 and 12%. Although there have been no previously reported cases of infection with Mycobacterium chelonae following total knee arthroplasty, this mycobacterium appears to be a potential pathogen in arthroplasty. When infection following total knee arthroplasty is evident but standard cultures come back negative, atypical mycobacterium infection should be considered. Mycobacterium chelonae does not grow in the normally allotted culture time, so false negative results are common. Once identified, M. chelonae is difficult to treat because of its resistance to standard drug therapies. Details of the first reported successful diagnosis and treatment of an infection with M. chelonae following a total knee arthroplasty are reported.
authors.affiliation: Department of Orthopaedics, University of Colorado Health Sciences, Center, Denver 80262, USA.
authors.forename: M
authors.initials: M
authors.lastname: Pring
authors.forename: D G
authors.initials: DG
authors.lastname: Eckhoff
mesh_terms: D000368:Aged; D000583:Amikacin / Q000627:therapeutic use; D002440:Cefoxitin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000382:microbiology*; D016926:Mycobacterium chelonae / Q000302:isolation & purification*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D002440:Cefoxitin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000583:Amikacin