Cure of short- and long-term experimental Chagas' disease using D0870.
Chagas' disease, a protozoan infection by the kinetoplastid Trypanosoma cruzi, constitutes a major public health problem in Latin America. With the use of mouse models of both short- and long-term forms of the disease, the efficacy of D0870, a bis-triazole derivative, was tested. D0870 was able to prevent death and induced parasitological cure in 70 to 90 percent of animals, in both the short- and long-term disease. In contrast, currently used drugs such as nifurtimox or ketoconazole prolonged survival but did not induce significant curing effects. D0870 may be useful in the treatment of human long-term Chagas' disease, a condition that is currently incurable.
Urbina
J A
JA
Laboratorio de Química Biológica, Centro de Bioquímica y Biofísica, Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020A, Venezuela.
Payares
G
G
Molina
J
J
Sanoja
C
C
Liendo
A
A
Lazardi
K
K
Piras
M M
MM
Piras
R
R
Perez
N
N
Wincker
P
P
Ryley
J F
JF
D000818:Animals; D001483:Base Sequence; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004334:Drug Administration Schedule; D007654:Ketoconazole / Q000627:therapeutic use; D008969:Molecular Sequence Data; D009547:Nifurtimox / Q000627:therapeutic use; D013261:Sterols / Q000096:biosynthesis; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000378:metabolism
D013261:Sterols; D014230:Triazoles; D014344:Trypanocidal Agents; C058219:ICI 195739; D009547:Nifurtimox; D007654:Ketoconazole