[Lung disease induced by isotretinoin].
A young man without any past history of note had taken isotretinoin for disfiguring acne before the summer season. He presented with a severe bilateral pneumonia, associated with dyspnoea two months after the start of treatment. On the pulmonary radiography there was a bilateral ground glass appearance which was worse on the right. The elevated level of eosinophils (54% in 564,000 cells/ml) in the alveolar lavage lead to a diagnosis of allergic pneumonia. The rapidly favourable outcome following the cessation of the medication and with the addition of corticosteroids seemed to us a supplementary argument in favour of a diagnosis of eosinophilic pneumonia, due to isotretinoin which seemed the primary initiating factor.
Oliviero
G
G
Service de Pneumologie et Médecine Interne, CHG Longjumeau.
Constans
P
P
Caby
I
I
De Rohan Chabot
P
P
Lacherade
J C
JC
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D015474:Isotretinoin / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D007641:Keratolytic Agents; D015474:Isotretinoin; D006854:Hydrocortisone; D008775:Methylprednisolone
Pneumopathie induite par l'isotrétinoïne.