Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection.
In order to elucidate the role of interleukin 8 (IL-8) in the development of chronic lung disease (CLD) of neonates with intra-uterine infection, serial and simultaneous measurements of the concentration of IL-8 and granulocyte elastase alpha 1 proteinase inhibitor complex (E-alpha 1 PI) in the tracheobronchial aspirate of low birth weight infants were conducted. Infants with a high serum IgM level at birth, and who subsequently developed CLD, showed significantly high concentrations of IL-8 and E-alpha 1 PI in the first 48 h. It seemed that IL-8 stimulated neutrophils to release neutrophil enzymes which, in turn, caused the lung tissue injury, resulting in the development of CLD following intra-uterine infection.
Takasaki
J
J
Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan.
Ogawa
Y
Y
D001980:Bronchi / Q000378:metabolism*; D005315:Fetal Diseases; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007239:Infections / Q000150:complications*; D016209:Interleukin-8 / Q000378:metabolism*; D019272:Leukocyte Elastase; D008173:Lung Diseases, Obstructive / Q000209:etiology / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000378:metabolism*; D013396:Suction; D014132:Trachea / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D016209:Interleukin-8; D000515:alpha 1-Antitrypsin; C037741:alpha 1-antitrypsin-leukocyte elastase complex; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase