[Intra-epidermal pustulosis in a child. Demonstration of a target antigen similar to foliaceus pemphigus antigen].
BACKGROUND
Intraepidermal IgA pustulosis is a vesiculopustular dermatosis defined by pemphigus type intercellular deposit exclusively of IgA. It is a member of the pemphigus group and may be related to neurtrophilic dermatoses.


METHODS
A child had vesiculopustular lesions of the limbs since the age of 11 years. Biopsy showed the subcorneal intraepidermal nature of the pustules and exclusive IgA deposit throughout the epiderma. Indirect immunofluorescence and protein immunoelectrophoreses were negative. Immunotransfer to beef tongue extract evidenced a 150-160 kDa band corresponding to IgA and IgG desmoglein. Treatment with general corticosteroids followed by pristinamycin was successful.


CONCLUSIONS
This is the first case report showing evidence of antiepidermal antibodies directed against the superficial pemphigus antigen.
Cordoliani
F
F
Service de Dermatologie, Hôpital Saint-Louis, Paris.
Rybojad
M
M
Verola
O
O
Dallot
A
A
Flageul
B
B
Didierjean
L
L
Drouault
Y
Y
Morel
P
P
D000367:Age Factors; D001324:Autoantigens / Q000302:isolation & purification*; D015820:Cadherins / Q000302:isolation & purification*; D002648:Child; D051183:Desmoglein 1; D004817:Epidermis / Q000276:immunology / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology* / Q000473:pathology
D001324:Autoantigens; D015820:Cadherins; D051183:Desmoglein 1; D007070:Immunoglobulin A
Pustulose intraépidermique à IgA chez un enfant: Mise en évidence d'un antigène cible identique à celui du pemphigus superficiel.