title: Myelodysplasia associated with Turner syndrome.
abstract: OBJECTIVE
  This study reports the association of myelodysplasia with Turner syndrome.
  
  
  METHODS
  An 11-year-old girl with Turner syndrome was found to have mild macrocytic anemia that persisted during 2 years.
  
  
  RESULTS
  Examination of the bone marrow revealed dyserythropoietic features with multinucleation consistent with refractory anemia. Levels of hemoglobin F were also markedly elevated (57%). She also had transient neutropenia and thrombocytopenia, as well as abnormal platelet function studies. The hematopoietic abnormalities were mild and may have been missed were she not followed for her hypertension and aortic coarctation.
  
  
  CONCLUSIONS
  Myelodysplastic syndromes in children are frequently associated with chromosomal abnormalities, but an association with Turner syndrome has not been previously described. This could be due to the fact that mild hematopoietic abnormalities in these patients may not be investigated.
authors.affiliation: Department of Pediatrics, The Medical University of South Carolina, Charleston 29425, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Foster
authors.forename: M R
authors.initials: MR
authors.lastname: Abboud
authors.forename: A B
authors.initials: AB
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Barredo
authors.forename: J
authors.initials: J
authors.lastname: Lazarchick
authors.forename: J
authors.initials: J
authors.lastname: Laver
mesh_terms: D000740:Anemia / Q000150:complications; D000748:Anemia, Macrocytic / Q000150:complications; D001792:Blood Platelets / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications* / Q000473:pathology; D009503:Neutropenia; D013921:Thrombocytopenia; D014424:Turner Syndrome / Q000097:blood / Q000150:complications* / Q000473:pathology
chemical_list: D005319:Fetal Hemoglobin