Vincristine-induced alterations in Schwann cells of mouse peripheral nerve.
The sciatic nerve of C57Bl mice was examined with a transmission electron microscope to study the ultrastructural alterations in Schwann cells following treatment with escalating doses of vincristine. Results indicated that the drug exerts a dose-related effect. Total doses up to 8 micrograms/mouse did not cause any visible damage to Schwann cells. Higher doses induced not only damage to individual cells, but also affected a greater percentage of them. The myelin sheath was the most affected organelle. Schwann cells of myelinated fibers showed greater damage than those of unmyelinated fibers.
Djaldetti
R
R
Department of Neurology, Beilinson Medical Center, Petah Tiqva, Israel.
Hart
J
J
Alexandrova
S
S
Cohen
S
S
Beilin
B Z
BZ
Djaldetti
M
M
Bessler
H
H
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D009412:Nerve Fibers / Q000187:drug effects / Q000648:ultrastructure; D012583:Schwann Cells / Q000187:drug effects* / Q000648:ultrastructure*; D012584:Sciatic Nerve / Q000187:drug effects* / Q000648:ultrastructure*; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine