title: MRI in patients with general paresis.
abstract: Few cases of MRI in neurosyphilis have been reported. We examined the value of MRI in patients with general paresis; MRI was performed on four HIV-negative patients with parenchymatous neurosyphilis. It demonstrated frontal and temporal atrophy, subcortical gliosis and, in one patient, increased ferritin in the basal ganglia. The progression of the lesions on MRI correlated well with the neuropsychiatric disturbances. The MRI findings correlated with the well-known neuropathological findings. This combination of pathological findings in neurosyphilis has not been described before and we suggest that MRI is of prognostic value in patients with general paresis.
authors.affiliation: Department of Neurology, Kaiser Franz Josef Spital, Vienna, Austria.
authors.forename: U
authors.initials: U
authors.lastname: Zifko
authors.forename: D
authors.initials: D
authors.lastname: Wimberger
authors.forename: K
authors.initials: K
authors.lastname: Lindner
authors.forename: G
authors.initials: G
authors.lastname: Zier
authors.forename: W
authors.initials: W
authors.lastname: Grisold
authors.forename: E
authors.initials: E
authors.lastname: Schindler
mesh_terms: D000328:Adult; D001284:Atrophy; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D005293:Ferritins / Q000032:analysis; D005911:Gliosis / Q000175:diagnosis; D018023:HIV Seronegativity; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009494:Neurosyphilis / Q000175:diagnosis*; D011379:Prognosis
chemical_list: D005293:Ferritins