title: Putative effect of silymarin on sawfly (Arge pullata)-induced hepatotoxicosis in sheep.
abstract: The prevention of hepatotoxicity from sawfly larvae (Arge pullata) was studied in 8 lambs by using silymarin, a botanical compound isolated from Silybum marianum. Of 2 lambs dosed orally with larvae only, 1 had a marked toxic response whereas the other responded poorly as judged from clinical parameters, blood biochemistry and pathology. Two lambs treated with penicillin, glucose and silymarin 7 and 24 h after larvae dosing were not affected by toxicosis, whereas 2 lambs treated similarly but without silymarin responded intermediate to the other 2 groups. Our study suggests a favorable effect using silymarin in treatment of sawfly larvae-induced ruminant hepatotoxicosis.
authors.affiliation: Department of Clinical Studies, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: S M
authors.initials: SM
authors.lastname: Thamsborg
authors.lastname: Jørgensen
authors.forename: E
authors.initials: E
authors.lastname: Brummerstedt
authors.forename: J
authors.initials: J
authors.lastname: Bjerregard
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D004357:Drug Synergism; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D006927:Hymenoptera / Q000502:physiology*; D007814:Larva / Q000502:physiology; D007958:Leukocyte Count / Q000662:veterinary; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*; D009929:Organ Size / Q000187:drug effects; D010406:Penicillins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology* / Q000517:prevention & control; D012838:Silymarin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006454:Hemoglobins; D010406:Penicillins; D012838:Silymarin; D005947:Glucose