Recent progress in breast cancer research at Osaka Medical Center for Cancer and Cardiovascular Diseases.
The Cancer Registry started in Osaka Prefecture in the early Sixties has shown a steady and significant increase in breast cancer incidence. The rate in 1992 was 34 out of 100,000 female population. Breast conserving therapy was applied increasingly in more patients, and 52% received this therapy in 1994. The results (survival and disease-free) for 372 patients were no lower than those for conventional mastectomy. Clonal analysis utilizing RFLP of phosphoglycerokinase gene and PCR revealed that most of so-called multicentric tumors in the breast were intraductally spread lesions (multifocal, not multicentric) and demonstrated that phyllodes tumor is a neoplasm of mesenchymal cells, not of epithelial cells.
Koyama
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Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
D000970:Antineoplastic Agents / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D015994:Incidence; D007261:Infusions, Intra-Arterial; D007564:Japan / Q000453:epidemiology; D008408:Mastectomy; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm