Targeted contrast agents in MR imaging.
The use of target specific MR contrast agents can dramatically improve information obtained by MR imaging. This review outlines the various components of target specific MR contrast agents, including various carriers (e.g., monoclonal antibodies, peptides, proteins, polysaccharides, polymers, liposomes, and cells) as well as magnetic labels (e.g., metal ion chelates, free radicals, and iron oxides) and focusses on some promising clinical applications.
Gupta
H
H
MR Pharmaceutical Program, MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Weissleder
R
R
D000911:Antibodies, Monoclonal; D003287:Contrast Media; D004419:Dysprosium; D005290:Ferric Compounds; D005609:Free Radicals; D005682:Gadolinium; D006801:Humans; D007501:Iron; D008081:Liposomes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese; D010455:Peptides; D011108:Polymers; D011134:Polysaccharides; D011506:Proteins
D000911:Antibodies, Monoclonal; D003287:Contrast Media; D005290:Ferric Compounds; D005609:Free Radicals; D008081:Liposomes; D010455:Peptides; D011108:Polymers; D011134:Polysaccharides; D011506:Proteins; D004419:Dysprosium; C000499:ferric oxide; D008345:Manganese; D005682:Gadolinium; D007501:Iron