Increased regional systolic myocardial stiffness of the left ventricle during coronary artery occlusion in a dog: analysis of the finite element model.
(1) We measured the instantaneous systolic transfer function of an isolated canine left ventricle (LV) before and after the ligation of the left anterior descending coronary artery (LAD). The instantaneous transfer function before the ligation of the LAD showed a resonance curve whose peak frequency was 30 to 70 Hz. On the other hand, the transfer function 40 min after the ligation of the LAD showed a divided peak in the resonance curve. (2) We constructed a finite element model of a thick-walled spherical shell with a non-uniform structure. In this model, the myocardial elasticity and viscosity of the ischemic region are different from those of non-ischemic regions. One can calculate the theoretical transfer function using modal analysis and also estimate the elasticity and the viscous coefficient of both non-ischemic and ischemic myocardium by fitting the theoretical transfer function to the experimental one. (3) The estimated elasticity of the ischemic myocardium was three to five times larger than that of the non-ischemic myocardium. The estimated viscous coefficient of the ischemic myocardium was about half that of the non-ischemic myocardium. These results showed that ischemia alters the viscoelastic properties of the myocardium during systole as well as during diastole.
Honda
H
H
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Tani
J
J
Miyazaki
T
T
Koiwa
Y
Y
Takishima
T
T
Shirato
K
K
D000818:Animals; D003324:Coronary Artery Disease / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D004285:Dogs; D004548:Elasticity; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D008954:Models, Biological; D012039:Regional Blood Flow / Q000502:physiology; D013599:Systole / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*; D014783:Viscosity