title: Further minor metabolites of staurosporine produced by a Streptomyces longisporoflavus strain.
abstract: From the staurosporine producing strain R-19 Streptomyces longisporoflavus various minor metabolites were isolated: They include new compounds with a keto function at carbon 4' of staurosporine and several metabolites related to TAN-1030A. The new structures were elucidated by spectroscopic methods, mainly 1H NMR and 13C NMR and by comparison with TAN-1030A. The new compounds inhibited protein kinase C with IC50 values in the micromolar range with the exception of those compounds that are alkylated at the lactam nitrogen.
authors.affiliation: CIBA-GEIGY Ltd., Basel, Switzerland.
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: A
authors.initials: A
authors.lastname: Fredenhagen
authors.forename: P
authors.initials: P
authors.lastname: Hug
authors.forename: T
authors.initials: T
authors.lastname: Meyer
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D002227:Carbazoles; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007211:Indoles; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D019311:Staurosporine; D013302:Streptomyces; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D002227:Carbazoles; D004791:Enzyme Inhibitors; D007211:Indoles; C061876:TAN 1030A; D011493:Protein Kinase C; D019311:Staurosporine