[Effect of induction of enzymes of the cytochrome p-450 system on the survival of rats after acute hemorrhage].
The effect of acute hemorrhage on the functional status of microsomal cytochrome P-450-dependent hepatic monoxygenases and the impact of induction of these monoxygenases on the survival of posthemorrhagic male Wistar rats. Acute blood loss of the rats, which caused 50% deaths led approximately to a double decrease in the hepatic activity of 77-ethoxycoumarin-O-deethylase (ECOD). Induction of hepatic monoxygenases by phenobarbital in a dose of 80 mg/kg for 3 days, which caused a 2.4-fold increase in the activity of ECOD as compared with the controls, prolonged the survival rate of posthemorrhagic rats from 50 to 85%.
Astashkin
E I
EI
Prikhod'ko
A Z
AZ
Matiushin
A I
AI
D000208:Acute Disease; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D006470:Hemorrhage / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate
D003577:Cytochrome P-450 Enzyme System
Vliianie induktsii fermentov sistemy tsitokhroma P-450 na vyzhivaemost' krys pri ostroĭ krovopotere.