title: Synthesis and antibacterial activity of C-4 thio- and dithiocarbamate monobactam derivatives.
abstract: New series of monobactam antibiotics, bearing thio-and dithiocarbamate derivatives as C-4 side chain, were synthesized. Some compounds were found to have good antibacterial activity against Gram-negative bacteria.
authors.affiliation: Lusofarmaco, Laboratorio di Ricerca Chimica, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cascio
authors.forename: L
authors.initials: L
authors.lastname: Lorenzi
authors.forename: D
authors.initials: D
authors.lastname: Caglio
authors.forename: E
authors.initials: E
authors.lastname: Manghisi
authors.forename: F
authors.initials: F
authors.lastname: Arcamone
authors.forename: G
authors.initials: G
authors.lastname: Guanti
authors.forename: G
authors.initials: G
authors.lastname: Satta
authors.forename: G
authors.initials: G
authors.lastname: Morandotti
authors.forename: R
authors.initials: R
authors.lastname: Sperning
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000138:chemical synthesis* / Q000494:pharmacology; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008997:Monobactams; D013859:Thiocarbamates