title: The relationship of oxygen consumption measured by indirect calorimetry to oxygen delivery in critically ill patients.
abstract: OBJECTIVE
  The existence of oxygen supply dependency, defined as oxygen consumption (VO2) limited by oxygen delivery (DO2), is still questioned. This study examined the relationship between VO2 and DO2 in two groups of critically ill surgical patients 50 years and older in the first 24 hours of resuscitation after pulmonary artery catheter insertion. Group 1 patients had systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and adult respiratory distress syndrome (ARDS). Group 2 patients had hemorrhagic shock.
  
  
  METHODS
  Study methodology included (1) augmenting DO2 with fluids, blood, and vasopressors, (2) measuring VO2 by indirect calorimetry to avoid the problem of mathematical coupling with DO2 calculation, and (3) analyzing data during steady states of temperature, sedation, paralyzing agents, and vasopressors.
  
  
  RESULTS
  Six to 18 measurements collected on all study patients during a period within the first 24 hours were analyzed using a linear regression analysis. Statistical significance was set at p < or = 0.05. Seven of nine patients in group 1 demonstrated positive, statistically significant relationships between VO2 and DO2. Of six patients in group 2, one patient demonstrated a positive, significant relationship of VO2 and DO2, three demonstrated inverse relationships, and two patients did not show a DO2/VO2 relationship. Supply dependency did not exist in all patients but was present in seven out of nine patients with systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, and adult respiratory distress syndrome in the first 24 hours of treatment.
authors.affiliation: Department of Surgery, University of Hawaii, Honolulu 96813, USA.
authors.forename: M
authors.initials: M
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Burchell
authors.forename: S A
authors.initials: SA
authors.lastname: Takiguchi
authors.forename: J J
authors.initials: JJ
authors.lastname: McNamara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002153:Calorimetry, Indirect; D002302:Cardiac Output; D016638:Critical Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000503:physiopathology; D012771:Shock, Hemorrhagic / Q000097:blood / Q000503:physiopathology
chemical_list: D010100:Oxygen