[Bone marrow transplantation: role of radiation therapy].
Conditioning regimes before bone marrow transplantation serve a dual purpose. Firstly they have to destroy the host immune system sufficiently to allow permanent engraftment, secondly they have to eliminate the abnormal tumor cells. The special aim of total body irradiation is to eradicate those cells, which escape chemotherapy. The effectiveness of TBI is influenced by: delivered dose, fraction size and dose rate. Dose escalation improves the results of TBI. The seven year survival probability is 74%, if more than 9,9 Gy are administered and only 38% under 9,9 Gy. Combining TBI and chemotherapy promotes the outcome in patients with acute leukaemia and allogeneic bone marrow transplantation. The two year relapse rate is 16% with and 37% without TBI. Side effects are distinctly determined by fraction size and dose rate.
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Klinik für Strahlentherapie und Radiologische Onkologie, Universität Düsseldorf.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000528:radiation effects*; D016026:Bone Marrow Transplantation / Q000379:methods*; D002386:Cataract / Q000209:etiology; D003131:Combined Modality Therapy; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D009393:Nephritis / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011658:Pulmonary Fibrosis / Q000209:etiology; D011829:Radiation Dosage; D014916:Whole-Body Irradiation / Q000009:adverse effects
Knochenmarktransplantation: Die Rolle der Strahlentherapie.