title: [Blood antioxidant defense in children with malignant disease. I. Plasma antioxidant activity and level of ceruloplasmin and transferrin].
abstract: In this study we examined selected elements of the antioxidant defence system in the plasma of children with the most common solid tumors (nephroblastoma, neuroblastoma, rhabdomyosarcoma, osteosarcoma). We observed a significant increase of plasma antioxidant activity (AOA) in the majority of the examined children. This factor changed during clinical treatment, i.e. induction of chemotherapy, surgery and/or radiotherapy and during maintenance chemotherapy. We conclude that the elevated plasma antioxidant activity in children with malignancy may be due to the higher concentration of ceruloplasmin in affected children than in their healthy counterparts.
authors.affiliation: Zakład Biochemii Instytutu Matki i Dziecka w Warszawie.
authors.forename: J
authors.initials: J
authors.lastname: Gajewska
authors.forename: M
authors.initials: M
authors.lastname: Szczypka
authors.forename: T
authors.initials: T
authors.lastname: Laskowska-Klita
authors.forename: D
authors.initials: D
authors.lastname: Perek
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D002570:Ceruloplasmin / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D014168:Transferrin / Q000032:analysis*
chemical_list: D000975:Antioxidants; D014168:Transferrin; D002570:Ceruloplasmin
vernacular_title: Obrona przeciwutleniajaca we krwi dzieci z choroba nowotworowa. Cześć I. Aktywność przeciwutleniajaca osocza oraz stezenie ceruloplazminy i transferyny.