Iohexol clearance for renal function measurement in gynaecologic cancer patients.
OBJECTIVE
To determine a valid and practical routine for glomerular filtration rate measurement in gynaecologic cancer patients.


METHODS
The established method, endogenous creatinine clearance, was compared to 51Cr-EDTA clearance and contrast medium clearance in 68 women with various gynaecologic carcinomas. Contrast medium clearance was determined in association with conventional urography (iohexal 300 mg I/ml, 40 ml) for evaluation of urinary tract involvement by the tumour. Automated X-ray fluorescence analysis equipment was used for the plasma analysis of iohexol and clearance calculations. Endogenous creatinine clearance and 51Cr-EDTA clearance were determined according to standard routine procedures. Simultaneous determinations of contrast medium clearance and 51Cr-EDTA clearance (n = 33), contrast medium clearance and endogenous creatinine clearance (n = 50), as well as 51Cr-EDTA clearance and endogenous creatinine clearance (n = 30) were compared.


CONCLUSIONS
The mean differences were -2.8 (SD 6.6), -1.8 (SD 22.3), and 2.7 (SD 18.3) ml/min/1.73 m2, respectively. It is concluded that contrast medium clearance is as adequate as 51Cr-EDTA clearance for glomerular filtration rate measurement. We suggest that contrast medium clearance should replace endogenous creatinine clearance, especially in patients referred for urography.
Lundqvist
S
S
Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.
Edbom
G
G
Groth
S
S
Stendahl
U
U
Hietala
S O
SO
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003404:Creatinine / Q000378:metabolism; D004492:Edetic Acid; D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D006801:Humans; D007472:Iohexol; D008875:Middle Aged; D013052:Spectrometry, X-Ray Emission; D014567:Urography
D003287:Contrast Media; D007472:Iohexol; D004492:Edetic Acid; D003404:Creatinine