Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.
In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes. Endogenous IL-10 was involved in regulating tumor necrosis factor alpha and IL-1beta secretion by human monocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.
Vecchiarelli
A
A
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
Retini
C
C
Monari
C
C
Tascini
C
C
Bistoni
F
F
Kozel
T R
TR
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000942:Antigens, Bacterial / Q000302:isolation & purification; D003455:Cryptococcus neoformans / Q000737:chemistry / Q000276:immunology*; D015536:Down-Regulation; D006801:Humans; D007108:Immune Tolerance; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology*; D011112:Polymyxin B / Q000494:pharmacology; D011134:Polysaccharides / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D007375:Interleukin-1; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; C014426:cryptococcal polysaccharide; D016753:Interleukin-10; C027478:glucuronoxylomannan; D011112:Polymyxin B