Acute effect of high-fat meals rich in either stearic or myristic acid on hemostatic factors in healthy young men.
Suggestions have been made that saturated fatty acids with 12-18 carbon atoms, stearic acid (18:0) in particular, are prothrombogenic. These suggestions are based mainly on in vitro measurements. In the present study the effect of dietary fats high in stearic or myristic acid (14:0) on plasma triacylglycerol concentrations and key variables of blood aggregation (in vitro and in vivo), coagulation, and fibrinolysis was studied over 24 h in 10 healthy young men. For each dietary fat, two identical high-fat test meals were served: one in the morning (0 h) and one 8 h later, and blood samples were collected at 0, 2, 4, 6, 8, and 24 h. Both fats decreased platelet aggregation compared with fasting values. Stearic fat resulted in a tendency toward lower activity of plasminogen activator inhibitor 1 (PAI-1) than did myristic fat (P < 0.08). PAI-1 was also lower 24 h after consumption of either fat than initially (P < 0.05). Stearic fat, but not myristic fat, tended to cause some increase in factor VII coagulant activity and beta-thromboglobulin after 4 h. In conclusion, an acute prothrombotic effect of fats high in myristic and stearic acid was not confirmed.
Tholstrup
T
T
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark. tth@kvl.dk or Tine.Tholstrup@fhe.kvl.dk
Andreasen
K
K
Sanström
B
B
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage*; D005167:Factor VII / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D019814:Myristic Acid; D009227:Myristic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D013229:Stearic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism
D004041:Dietary Fats; D009227:Myristic Acids; D017395:Plasminogen Activator Inhibitor 1; D010975:Platelet Aggregation Inhibitors; D013229:Stearic Acids; D014280:Triglycerides; D001620:beta-Thromboglobulin; D019814:Myristic Acid; C031183:stearic acid; D005167:Factor VII; D010959:Tissue Plasminogen Activator