title: [10 years transplantation of bone marrow and hematopoietic stem cells in adults at the Hannover Medical School].
abstract: METHODS
  From January 1986 until August 1995 230 adult patients received an allogeneic or autologous transplantation of bone marrow or hematopoietic blood stem cells. The conditioning and myeloablative treatment regimens were chosen according to the underlying disease and type of transplant.
  
  
  RESULTS
  The observation period comprises 1 to 115 months after transplantation. After allogeneic transplantation from HLA-identical family donors, the probabilities of disease-free survival were for acute myeloid leukemia in first complete remission (CR) (n = 35) 77%, for acute lymphoid leukemia in 1st CR (n = 7) 72% and in 2nd CR (n = 10) 40%, in first chronic phase of chronic myeloid leukemia (n = 34) 50% and in severe aplastic anemia (n = 7) 100%. Following myeloablative therapy and autologous transplantation the probabilities of disease-free survival were 47% in relapsed Hodgkin's disease (n = 22) and 42% for relapsed high-grade non-Hodgkin's lymphoma (n = 12). Eight of 10 patients with acute myeloid and 7 of 8 with acute lymphoid leukemia suffered a leukemic relapse after autologous bone marrow transplantation. Three of 8 patients with relapsed testicular cancer survived relapse-free. Treatment failures were due to more advanced acute graft versus host disease after allogeneic transplantation and caused by relapse after autologous transplantation. Current protocols evaluate the allogeneic transplantation of enriched CD34+ blood stem cells. In chronic myeloid leukemia the autologous transplantation of blood stem cells after myeloablative therapy is being studied.
authors.affiliation: Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover.
authors.forename: H
authors.initials: H
authors.lastname: Link
authors.forename: H
authors.initials: H
authors.lastname: Diedrich
authors.forename: L
authors.initials: L
authors.lastname: Arseniev
authors.forename: M
authors.initials: M
authors.lastname: Stoll
authors.forename: W
authors.initials: W
authors.lastname: Ebell
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: J
authors.initials: J
authors.lastname: Tischler
authors.forename: J
authors.initials: J
authors.lastname: Casper
authors.forename: G
authors.initials: G
authors.lastname: Hübner
authors.forename: P
authors.initials: P
authors.lastname: Schöffski
authors.forename: S
authors.initials: S
authors.lastname: Diehl
authors.forename: A
authors.initials: A
authors.lastname: Goes
authors.forename: R
authors.initials: R
authors.lastname: Jacobs
authors.forename: J
authors.initials: J
authors.lastname: Kadar
authors.forename: W
authors.initials: W
authors.lastname: Stangel
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: K L
authors.initials: KL
authors.lastname: Rittmann
authors.forename: I
authors.initials: I
authors.lastname: Wildfang
authors.forename: P
authors.initials: P
authors.lastname: Bucsky
authors.forename: C
authors.initials: C
authors.lastname: Bettoni
authors.forename: R E
authors.initials: RE
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Riehm
authors.forename: H
authors.initials: H
authors.lastname: Poliwoda
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000401:mortality / Q000628:therapy*; D016026:Bone Marrow Transplantation; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D008223:Lymphoma / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged
vernacular_title: Zehn Jahre Transplantation von Knochenmark und hämatopoetischen Stammzellen bei Erwachsenen an der Medizinischen Hochschule Hannover.