title: Once-daily dosing of aminoglycosides.
abstract: Since their introduction one or more decades ago, aminoglycosides have generally been administered in multiple daily (i.e. twice- or thrice-daily) dosing regimens. However, nephrotoxicity can be reduced in animal models by administering the same total daily dose as one large dose instead of as multiple small doses. In addition, in vitro and in vivo studies that considered the impact of dosing regimens on efficacy suggest that once-daily dosing is equally or more effective compared to multiple daily dosing. Once-daily versus multiple daily dosing regimens have been compared for amikacin, netilmicin, and gentamicin in 24 randomized, clinical trials including a total of 3,181 patients. An analysis of these studies revealed superior results for once-daily regimens with respect to clinical efficacy (89.5% vs. 84.7%, p < 0.001) as well as bacteriological efficacy (88.6% vs. 83.4%, p < 0.01). No statistically significant differences were noted for toxicity. Nevertheless, both nephrotoxicity and ototoxicity occurred less frequently during once-daily dosing (4.5% vs. 5.5% and 4.2% vs. 5.8%, respectively). Finally, once-daily dosing is more economical, since less nursing time and infusion material are required and the efforts for drug monitoring can be reduced. In conclusion, amikacin, netilmicin, and gentamicin can be administered once a day.
authors.affiliation: Departement für Innere Medizin, Universitätsspital, Zürich, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Blaser
authors.forename: C
authors.initials: C
authors.lastname: König
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D001424:Bacterial Infections / Q000188:drug therapy; D004427:Ear Diseases / Q000139:chemically induced; D006168:Guinea Pigs; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D051379:Mice; D011817:Rabbits; D016032:Randomized Controlled Trials as Topic; D051381:Rats
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents