Isolation and structure of staph-cAM373 produced by Staphylococcus aureus that induces conjugal transfer of Enterococcus faecalis plasmid pAM373.
Enterococus faecalis plasmid pAM373 encodes a mating response to the sex pheromone, cAM373, which is secreted from pAM373-free E. faecalis. cAM373-like activity was detected in a culture filtrate of Staphylococcus aureus. The major active substance, termed staph-cAM373, was isolated, and its structure was identified as a H-Ala-IIe-Phe-IIe-Leu-Ala-Ala-OH heptapeptide.
Nakayama
J
J
Department of Applied Biological Chemistry, University of Tokyo, Japan.
Igarashi
S
S
Nagasawa
H
H
Clewell
D B
DB
An
F Y
FY
Suzuki
A
A
D000595:Amino Acid Sequence; D003227:Conjugation, Genetic / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000235:genetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010675:Pheromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010957:Plasmids; D013211:Staphylococcus aureus / Q000378:metabolism*
D009842:Oligopeptides; D010675:Pheromones; C100566:sex pheromone cAM373, Staphylococcus aureus