title: Patient stratification by cardiopulmonary status in the diagnosis of pulmonary embolism.
abstract: The purpose of this investigation is to provide further evidence in support of the interpretation of ventilation/perfusion (V/Q) lung scans on the basis of criteria dependent on whether or not the patient has prior cardiopulmonary disease (CPD).
  
  
  METHODS
  Data are from the collaborative PIOPED study. We evaluated the original PIOPED database to obtain the consensus probability estimates of pulmonary embolism (PE) among patients stratified according to the presence or absence of prior CPD.
  
  
  RESULTS
  Among patients with no prior CPD, nuclear physicians consistently underestimated the probability of PE (odds ratio 1.62, 95% confidence interval 1.10-2.38, p = .014).
  
  
  CONCLUSIONS
  Past experience guided nuclear physicians into correctly estimating the probability of acute PE on V/Q scans of patients with prior CPD. The criteria they subjectively used was inadequate for estimating the probability of acute PE in patients with no prior CPD. Different criteria, therefore, apply to the interpretation of V/Q scans in these two groups.
authors.affiliation: Michigan State University, Department of Radiology, East Lansing 48824-1313, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gottschalk
authors.forename: P D
authors.initials: PD
authors.lastname: Stein
authors.forename: J W
authors.initials: JW
authors.lastname: Henry
mesh_terms: D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D015995:Prevalence; D011336:Probability; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000453:epidemiology; D012372:ROC Curve; D011859:Radiography; D011877:Radionuclide Imaging; D014692:Ventilation-Perfusion Ratio