title: Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
abstract: Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Laurén, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
authors.forename: C F
authors.initials: CF
authors.lastname: Sier
authors.forename: F J
authors.initials: FJ
authors.lastname: Kubben
authors.forename: S
authors.initials: S
authors.lastname: Ganesh
authors.forename: M M
authors.initials: MM
authors.lastname: Heerding
authors.forename: G
authors.initials: G
authors.lastname: Griffioen
authors.forename: R
authors.initials: R
authors.lastname: Hanemaaijer
authors.forename: J H
authors.initials: JH
authors.lastname: van Krieken
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
mesh_terms: D000368:Aged; D017364:Collagenases / Q000032:analysis*; D005260:Female; D018093:Gelatinases / Q000032:analysis*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000032:analysis*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality; D015996:Survival Rate
chemical_list: D017364:Collagenases; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9