title: Hypotension during subarachnoid anaesthesia: haemodynamic effects of colloid and metaraminol.
abstract: We have studied 45 patients, aged 60-95 yr, receiving subarachnoid block for neck of femur fractures. Patient received either colloid (polygeline, Haemaccel) 8 ml kg-1 (n = 15), metaraminol 5 micrograms kg-1 and 1.7 micrograms kg-1 min-1 (n = 15) or a combination of both treatments to maintain systolic arterial pressure (SAP) between 75 and 100% of baseline. If necessary, additional colloid 2 x 4 ml kg-1 or metaraminol 3 x 2.5 micrograms kg-1 was given. Arterial pressure was measured by automated oscillotonometry, central venous pressure (CVP) by a manometer and cardiac index (CI), stoke index (SI) and heart rate (HR) by transthoracic electrical bioimpedance. Systemic vascular resistance index (SVRI) was derived. Colloid was less effective than metaraminol (P < 0.05). In the colloid group, SAP and SVRI decreased and CVP, CI and SI increased (P < 0.001). In the metaraminol group, initial decreases in SAP, SVRI and CVP were restored after 10-15 min and HR decreased after 12 min (P < 0.001). In the combined group, initial decreases in SAP and SVRI were restored after 4 and 16 min, and CVP, CI, SI and HR increased (P < 0.001). Metaraminol was more effective than colloid because it increased SVRI, whereas colloid increased CVP without significantly increasing CI.
authors.affiliation: Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong.
authors.forename: L A
authors.initials: LA
authors.lastname: Critchley
authors.forename: F
authors.initials: F
authors.lastname: Conway
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000775:Anesthesia, Spinal; D002496:Central Venous Pressure; D005260:Female; D005265:Femoral Neck Fractures / Q000601:surgery; D006339:Heart Rate; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008680:Metaraminol / Q000627:therapeutic use*; D008875:Middle Aged; D010952:Plasma Substitutes; D011097:Polygeline; D013997:Time Factors; D014655:Vascular Resistance
chemical_list: D010952:Plasma Substitutes; D008680:Metaraminol; D011097:Polygeline