[Radioprotective effect of gamma-harmine and its carboline analogues].
gamma-Harmine (I), harmine (II) and harmaline (III) were isolated from Peganum harmala L. (Zygophylaceae). Tests were conducted with mice to detect whether gamma-harmine (a new compound), harmine, harmol (IV) and harmalol (V) are effective radioprotective compounds against gamma-ray irradiation. Intraperitoneal injection of the hydrochlorides of the four alkaloids 50-80 mg.kg-1 X 1 in NIH male mice 30-45 minutes before 8.6-9.7 Gy whole body 60Co irradiation significantly increased the survival effects (1.33-2.61) and 30-day survival survival rate in comparison with control mice. The results indicate that gamma-harmine exhibited relatively good radioprotective effect. gamma-harmine is the first alkaloid isolated from a plant having protective effects against whole-body lethal irradiation in mice.
Li
G W
GW
Cancer Center, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Liang
P G
PG
Pan
G Y
GY
D000818:Animals; D003037:Cobalt Radioisotopes; D006247:Harmine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; C098576:gamma-harmine; D006247:Harmine