title: Effect of CO2 laser on spinal epidural fibrosis.
abstract: In this study the effect of CO2 laser on spinal epidural fibrosis was examined in 24 guinea pigs which were divided into two groups. The first group was the control group, the second one the CO2 laser group. All animals had laminectomies at 3 levels. Re-exploration was performed three months after the laminectomy. In the second group the same procedure was performed but at the end of the re-exploration, CO2 laser irradiation of the epidural fibrotic tissue was done. The wounds in both groups were closed again. Four months later all animals were sacrificed. For verification and quantification of scar formation (postoperative fibrosis) light microscopic examinations and determination of hydroxyproline were done, using Bergman's spectrophotometric method. The differences which were observed between the two groups were statistically significant (U : 134, P < 0.05). This study demonstrates the reducing effect of CO2 laser irradiation on epidural scar formation. The findings encourage its use as an alternative method of prevention of epidural fibrosis after spinal surgery.
authors.affiliation: Department of Neurosurgery, Inönü University, Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Colak
authors.forename: M
authors.initials: M
authors.lastname: Bavbek
authors.forename: N E
authors.initials: NE
authors.lastname: Aydin
authors.forename: N
authors.initials: N
authors.lastname: Renda
authors.forename: B
authors.initials: B
authors.lastname: Açikgöz
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000601:surgery*; D004824:Epidural Space / Q000473:pathology / Q000601:surgery*; D005355:Fibrosis; D006168:Guinea Pigs; D006909:Hydroxyproline / Q000032:analysis; D007796:Laminectomy; D053685:Laser Therapy; D011183:Postoperative Complications / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D013131:Spine / Q000473:pathology / Q000601:surgery; D014945:Wound Healing / Q000502:physiology
chemical_list: D006909:Hydroxyproline