A combination of vinblastine and doxorubicin with interferon alpha.
Advanced renal cell carcinoma still has poor overall treatment results, whatever chemotherapy is used. We treated 11 patients with advanced renal cell carcinoma with vinblastine (4 mg/m2) and doxorubicin (12 mg/m2) weekly, combined with recombinant IFN-alpha 2a given 3 x 10(6) IU s.c. three times per week during the first week, and 9 x 10(6) IU three times per week during the second week, and then on an ongoing basis 18 x 10(6) IU three times per week from the third week. The treatment of all patients had to be interrupted after 6 to 9 weeks because of leukopenia. Median survival was 6 months, and two partial responses were observed. We conclude that this regimen proved to be excessively toxic and failed to show significant advances compared with two-drug combination.
Jekunen
A
A
Department of Oncology, Helsinki University Central Hospital, Finland.
Pyrhönen
S
S
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D007680:Kidney Neoplasms / Q000188:drug therapy*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D015996:Survival Rate; D014747:Vinblastine / Q000008:administration & dosage* / Q000009:adverse effects
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014747:Vinblastine; D004317:Doxorubicin