title: [Acute organic psychosis after malaria tropica].
abstract: Neuropsychiatric complications in the course of plasmodium falciparum infection are usually summarized as cerebral malaria. Heterogeneous clinical symptoms, different courses and inconstant parasitemia, however, suggest different pathogenic mechanisms. We report a case of an acute symptomatic psychosis occurring two weeks after successful therapy of a primary manifestation of plasmodium falciparum infection. The diagnosis of meningoencephalitis was based on lymphocytic pleocytosis of cerebrospinal fluid and hyperintense lesions in cranial magnetic resonance imaging. Due to the lack of plasmodium falciparum parasitemia and of serological evidence of viral infection a final diagnosis was not possible. Considering the pertinent literature, an immune-mediated complication of plasmodium falciparum infection (acute disseminated encephalomyelitis, ADEM) appears to be more probable than a direct viral or plasmodium CNS infection. We propose to reverse the term cerebral malaria for the cases with direct pathogenic influence of plasmodium falciparum, and to distinguish it from cases with possible immune-mediated pathogenesis.
authors.affiliation: Psychiatrische Klinik, Universität Würzburg.
authors.forename: J
authors.initials: J
authors.lastname: Koch
authors.forename: W K
authors.initials: WK
authors.lastname: Strik
authors.forename: T
authors.initials: T
authors.lastname: Becker
authors.forename: K
authors.initials: K
authors.lastname: Fleischer
authors.forename: R
authors.initials: R
authors.lastname: Gold
authors.forename: E
authors.initials: E
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D000818:Animals; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology; D001921:Brain / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D016779:Malaria, Cerebral / Q000175:diagnosis* / Q000276:immunology; D016778:Malaria, Falciparum / Q000175:diagnosis* / Q000276:immunology; D008590:Meningoencephalitis / Q000175:diagnosis / Q000276:immunology; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000276:immunology; D009483:Neuropsychological Tests; D010963:Plasmodium falciparum / Q000276:immunology
vernacular_title: Akute körperlich begründbare Psychose nach Malaria tropica.