title: Dobutamine increases oxygen consumption during constant flow cardiopulmonary bypass.
abstract: We have studied the effects of flow and dobutamine on systemic haemodynamic variables, oxygen delivery (DO2) and oxygen consumption (VO2) in 20 patients during cardiopulmonary bypass (CPB) with mild hypothermia (34 degrees C). In a subgroup of seven patients, we also studied the effects on gastric microcirculatory blood flow (MCF) using laser Doppler flowmetry. During CPB, measurements were made before and after two interventions: the first consisted of increasing flow from 2.4 to 3.0 litre min-1 m-2 for 10 min; the second consisted of an infusion of dobutamine at a rate of 6 micrograms kg-1 min-1 for 10 min during constant flow CPB. There were no significant differences in DO2, VO2 or haemodynamic variables between the two baseline measurements. The increase in flow raised DO2 (27%, P < 0.001), mean arterial pressure (P < 0.01) and MCF (P < 0.01), but failed to increase VO2. In contrast, dobutamine infusion increased VO2 (11%, P < 0.001) during constant flow CPB without significant changes in DO2, systemic haemodynamic variables or MCF. These results indicate that increases in VO2 during dobutamine may be flow-independent.
authors.affiliation: Department of Anaesthesiology, University Hospital of Freiburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Karzai
authors.forename: A
authors.initials: A
authors.lastname: Lötte
authors.forename: M
authors.initials: M
authors.lastname: Günnicker
authors.forename: U M
authors.initials: UM
authors.lastname: Vorgrimler-Karzai
authors.forename: H J
authors.initials: HJ
authors.lastname: Priebe
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D011188:Potassium / Q000097:blood; D013270:Stomach / Q000098:blood supply
chemical_list: D001786:Blood Glucose; D002316:Cardiotonic Agents; D004280:Dobutamine; D011188:Potassium