title: Outcome analysis of preoperative embolization with N-butyl cyanoacrylate in cerebral arteriovenous malformations.
abstract: OBJECTIVE
  To determine the influence of preoperative N-butyl cyanoacrylate embolization on outcome in the treatment of cerebral arteriovenous malformations.
  
  
  METHODS
  Two groups were compared: 30 patients who underwent surgery and embolization versus 41 patients who underwent surgery only. Both groups were categorized by Spetzler-Martin grade and evaluated with the Glasgow Outcome Scale at various intervals. The long-term follow-up in months was, for surgery only, mean of 35 and range of 4 to 59, and for surgery and embolization, mean of 10 and range of 1 to 19).
  
  
  RESULTS
  The arteriovenous malformations in the surgery and embolization group had a larger average greatest diameter (4.2 +/- 1.5 cm versus 3.4 +/- 1.8 cm) and were of higher Spetzler-Martin grade (89% versus 68% grade III-V). No significant difference in the preoperative or immediate postoperative (less than 24 hours) Glasgow Outcome Scale was identified between the two groups. At I week after surgery, the surgery and embolization group displayed a significantly better outcome evaluation (70% versus 41% with Glasgow Outcome Scale score of 5). The long-term evaluation continued to favor the surgery and embolization patients (86% versus 66% with Glasgow Outcome Scale score of 5).
  
  
  CONCLUSIONS
  Preoperative N-butyl cyanoacrylate embolization improves postsurgical outcome.
authors.affiliation: Department of Radiology, Columbia-Presbyterian Medical Center, New York, NY 10032, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: DeMeritt
authors.forename: J
authors.initials: J
authors.lastname: Pile-Spellman
authors.forename: H
authors.initials: H
authors.lastname: Mast
authors.forename: N
authors.initials: N
authors.lastname: Moohan
authors.forename: D C
authors.initials: DC
authors.lastname: Lu
authors.forename: W L
authors.initials: WL
authors.lastname: Young
authors.forename: L
authors.initials: L
authors.lastname: Hacein-Bey
authors.forename: J P
authors.initials: JP
authors.lastname: Mohr
authors.forename: B M
authors.initials: BM
authors.lastname: Stein
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic; D004659:Enbucrilate; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D011300:Preoperative Care
chemical_list: D004659:Enbucrilate