Genetic analysis of ageing: role of oxidative damage and environmental stresses.
Evolutionary theory predicts substantial interspecific and intraspecific differences in the proximal mechanisms of ageing. Our goal here is to seek evidence for common ('public') mechanisms among diverse organisms amenable to genetic analysis. Oxidative damage is a candidate for such a public mechanism of ageing. Long-lived strains are relatively resistant to different environmental stresses. The extent to which these stresses produce oxidative damage remains to be established.
Martin
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GM
Department of Pathology and Genetics, University of Washington, Seattle 98195-7470, USA.
Austad
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SN
Johnson
T E
TE
D000375:Aging / Q000235:genetics*; D000818:Animals; D000830:Animals, Laboratory; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D004777:Environment; D006801:Humans; D008136:Longevity / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation; D018384:Oxidative Stress; D012377:Rodentia / Q000235:genetics; D012641:Selection, Genetic; D013045:Species Specificity