[Effects of interferon inducers on chemically-induced mutagenesis and carcinogenesis].
The murine bone marrow cellular chromosomal aberration technique was used to reveal anticlastogenic effects of the natural interferon inductors ridostin and larifan, as well as the synthetic ones polyguacil and amyxin. The action of the interferon inductors was timed to the maximum production of interferon in the body. Anticarcinogenic, antitumor, and antimetastatic properties of the above interferon inductors were found by using classical experimental models of carcinogenesis. Some mechanisms of antimutagenic and coupled anticarcinogenic action of interferon inductors were considered. The natural interferon inductor larifan was found to have an antipromoter activity. The treatment regimen by using interferon inductors in combination with the immunomodulator thymosin, a thymic hormone, was under discussion.
Loginova
N S
NS
Kinzirskiĭ
A S
AS
Parshina
O V
OV
Mirskaia
E E
EE
Ershov
F I
FI
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004359:Drug Therapy, Combination; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D009930:Organic Chemicals; D011066:Poly C / Q000494:pharmacology; D011068:Poly G / Q000494:pharmacology; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012331:RNA, Fungal / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013947:Thymosin / Q000008:administration & dosage / Q000627:therapeutic use; D013994:Tilorone / Q000494:pharmacology
D016587:Antimutagenic Agents; D007369:Interferon Inducers; D009930:Organic Chemicals; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; C066530:larifan; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D013947:Thymosin; D013994:Tilorone
Vliianie induktorov interferona na khimicheski indutsirovannyĭ mutagenez i kantserogenez.