[Inhibition of ornithine decarboxylase activity and epidermal papilloma in mice by beta-carotene].
Anticarcinogenic action of beta-carotene was analyzed with determination of ornithine decarboxylase (ODC) activity induced by TPA and a two-stage model of skin papilloma-genesis in mice. Results showed increase of ODC activity induced by TPA could be significantly inhibited, onset of tumor postponed, and number of tumor foci decreased by beta-carotene. It suggested beta-carotene had an obvious chemoprophylactic effect on tumor.
Tan
A
A
Department of Epidemiology, Tongji Medical University, Wuhan.
Wu
K
K
Huang
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010212:Papilloma / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate; D019207:beta Carotene
D016588:Anticarcinogenic Agents; D019207:beta Carotene; D002338:Carotenoids; D015127:9,10-Dimethyl-1,2-benzanthracene; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate