title: Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661.
abstract: We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iso
authors.forename: T
authors.initials: T
authors.lastname: Irie
authors.forename: T
authors.initials: T
authors.lastname: Iwaki
authors.forename: M
authors.initials: M
authors.lastname: Kii
authors.forename: Y
authors.initials: Y
authors.lastname: Sendo
authors.forename: K
authors.initials: K
authors.lastname: Motokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nishitani
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000077726:Doripenem; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem