Effect of acyclovir on rat fetus palate mucosa.
Five pregnant rats were treated during organogenesis with sc injections of acyclovir (50 mg/kg body weight) on days 9, 10 and 11 of pregnancy. The fetuses (N=62) were evaluated on day 20 of gestation and presented decreased body weight as well as delayed differentiation of fetal rat palate epithelium, with increased nuclear volume, decreased cytoplasmic and cellular volumes, decreased epithelial and keratin thicknesses, and increased cellular numerical density.
Komesu
M C
MC
Departamento de Estomatologia, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Brasil.
Brentegani
L G
LG
Azoubel
R
R
Lopes
R A
RA
Sala
M A
MA
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000212:Acyclovir / Q000633:toxicity*; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004848:Epithelium / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology; D005260:Female; D009061:Mouth Mucosa / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology; D010159:Palate / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology*; D010160:Palate, Soft / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013723:Teratogens / Q000494:pharmacology*
D000998:Antiviral Agents; D013723:Teratogens; D000212:Acyclovir