title: [A case of recurrent breast carcinoma with metastatic foci in the lung and pleura treated successfully with biochemical modulation of 5-fluorouracil by low-dose cisplatin].
abstract: A 65-year-old female received nipple preserved total glandectomy for breast carcinoma. A 250 mg dose of epirubicin was administered as an adjuvant. After a three-year disease-free interval, breast carcinoma recurred in the lung and pleura. We then used biochemical modulation of 5-fluorouracil by low-dose cisplatin. One course of biochemical modulation resulted in eighty-three percent tumor regression and complete disappearance of the pleural effusion for over six months.
authors.affiliation: Dept. of Surgery, Wakayama Medical College, Kihoku Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oura
authors.forename: T
authors.initials: T
authors.lastname: Sakurai
authors.forename: G
authors.initials: G
authors.lastname: Yoshimura
authors.forename: T
authors.initials: T
authors.lastname: Tamaki
authors.forename: T
authors.initials: T
authors.lastname: Umemura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D010997:Pleural Neoplasms / Q000556:secondary* / Q000628:therapy*
chemical_list: D007155:Immunologic Factors; D002945:Cisplatin; D005472:Fluorouracil