title: Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats.
abstract: OBJECTIVE
  To search for female contraceptive agents.
  
  
  METHODS
  2-Hydroxy-3-methyl-1, 4-naphthoquinone monosemicarbazone (HMNQS) and 2-hydroxy-1, 4-naphthoquinone monothiosemicarbazone (HNQTS) were screened for anti-implantation activity in rats.
  
  
  RESULTS
  Both compounds showed a dose-dependent activity, and HNQTS was more potent. An 100% anti-implantation activity was observed with HNQTS 150 mg kg-1 ig. Its LD50 was found to be > 2 g kg-1 ig in mice.
  
  
  CONCLUSIONS
  HNQTS was more potent than HMNQS for anti-implantation activity in rats.
authors.affiliation: Pharmacology Division, Regional Research Laboratory, Jammu Tawi, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Dhar
authors.forename: S
authors.initials: S
authors.lastname: Mattu
mesh_terms: D000818:Animals; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology* / Q000633:toxicity; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D009285:Naphthoquinones / Q000494:pharmacology* / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000033:anatomy & histology
chemical_list: D003283:Contraceptives, Postcoital, Synthetic; D009285:Naphthoquinones; C098503:2-hydroxy-3-methyl-1,4-naphthoquinone monosemicarbazone; C098504:2-hydroxy-1,4-naphthoquinone monothiosemicarbazone