[Elimination of asialoorosomucoid and its catabolism in liver of rats with toxic CCl4-induced cirrhosis].
Human 125I-acyaloorosomucoid was intravenously injected to male Wistar rats. Hepatic cirrhosis was induced by oily CCl4 solution (0.04 ml toxin per 100 g body weight, twice a week for 2 months). Cirrhosis was found not to prevent blood elimination of 125I-acyaloorosomucoid (t1/2 = 2.53 versus 2.50 in the control). Ten minutes after injection, there was 75.2% of the administered radioactive dose in the liver versus 77.1% in the control. The 60-minute hepatic elimination of substrate in rats with cirrhosis was even more intensive than in the control animals, which is in agreement with the high levels of acid-soluble radioactivity (for 10 minutes). By large, CCl4-induced hepatic cirrhosis did not lead to disturbances of the hepatocytic function aimed at endocytosis and catabolism of acyaloorosomucoid.
Pupyshev
A B
AB
Shorina
G N
GN
Rukavishnikova
E V
EV
D000818:Animals; D001212:Asialoglycoproteins / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D001212:Asialoglycoproteins; D009961:Orosomucoid; C017030:asialoorosomucoid
Vyvedenie iz krovi i katabolizm asialoorozomukoida v pecheni krys s toksicheskim CCl4-tsirrozom.