title: Hearts from donors with chronic alcohol use: a possible risk factor for death after heart transplantation.
abstract: BACKGROUND
  Careful donor and recipient selection are important factors for the success of heart transplantation. Currently, donors with a history of alcohol use are routinely accepted despite the potential deleterious effects of alcohol on the heart.
  
  
  METHODS
  We examined the frequency of chronic alcohol use (> 2 ounces of pure alcohol daily for > or = 3 months) among organ donors and the outcome of the receipients after heart transplantation. Of 99 consecutive patients who underwent transplantation between December 1988 and August 1993 with an adequate donor history, 17 (17%) had a history of chronic alcohol use (alcohol group), and 82 (83%) did not (nonalcohol group). All recipients received triple-drug immunosuppression, and 10 to 14 days of OKT3.
  
  
  RESULTS
  Survival rates at 1 and 2 years were significantly lower in the alcohol group (61% +/- 13% and 61$ +/- 13%) than in the nonalcohol group (95% +/- 3% and 91% +/-4%, p = 0.0001). Most deaths in the alcohol group occurred within 3 months after transplantation. The incidence of rejection episodes did not differ significantly. Fatal rejection occurred more frequently in the alcohol group and was associated with severe ventricular dysfunction before death. Cox multiple regression analysis identified donor alcohol use as an independent risk factor for death after heart transplantation.
  
  
  CONCLUSIONS
  A substantial proportion (17%) of heart donors have a history of chronic alcohol use. The unfavorable early outcome of patients receiving hearts from alcoholic donors suggests the presence of a subclinical alcoholic cardiomyopathy before transplantation and poor tolerance of rejection episodes after transplantation. Larger prospective studies are needed to determine the mechanism of fatal rejection and whether such hearts can be used safely for transplantation.
authors.affiliation: Divisions of Cardiology, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048-1865, USA.
authors.forename: D
authors.initials: D
authors.lastname: Freimark
authors.forename: I
authors.initials: I
authors.lastname: Aleksic
authors.forename: A
authors.initials: A
authors.lastname: Trento
authors.forename: J J
authors.initials: JJ
authors.lastname: Takkenberg
authors.forename: M
authors.initials: M
authors.lastname: Valenza
authors.forename: D
authors.initials: D
authors.lastname: Admon
authors.forename: C
authors.initials: C
authors.lastname: Blanche
authors.forename: C A
authors.initials: CA
authors.lastname: Queral
authors.forename: C G
authors.initials: CG
authors.lastname: Azen
authors.forename: L S
authors.initials: LS
authors.lastname: Czer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002310:Cardiomyopathy, Alcoholic / Q000401:mortality*; D002423:Cause of Death; D002648:Child; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000401:mortality; D016027:Heart Transplantation / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality*; D012307:Risk Factors; D015996:Survival Rate; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D000431:Ethanol