title: Biochemical effects of garlic protein diet and garlic oil on glycosaminoglycan metabolism in cholesterol fed rats.
abstract: Garlic protein diet or daily administration of garlic oil to 2% cholesterol fed rats controlled significantly the increases in sulphated glycosaminoglycans in their heart and aorta. However hyaluronic acid level increased. UDPG dehydrogenase decreased and several degrading enzymes increased in the aorta on treatment. The effects of treatment were just the reverse in liver. The high percentage of cysteine in garlic protein and the reactive disulphide group in the oil may be responsible for their beneficial effects.
authors.affiliation: Department of Biochemistry, University of Kerala, Thiruvananthapuram, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Mathew
authors.forename: K T
authors.initials: KT
authors.lastname: Augusti
mesh_terms: D000498:Allyl Compounds; D000818:Animals; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D005737:Garlic; D006025:Glycosaminoglycans / Q000378:metabolism*; D008297:Male; D010938:Plant Oils / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D002791:Cholesterol, Dietary; D006025:Glycosaminoglycans; D010938:Plant Oils; D010940:Plant Proteins; D013440:Sulfides; C038491:allyl sulfide