title: The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein.
abstract: In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expression.
authors.affiliation: Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: S L
authors.initials: SL
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Huang
authors.forename: T C
authors.initials: TC
authors.lastname: Tsai
authors.forename: K Y
authors.initials: KY
authors.lastname: Lu
authors.forename: Y P
authors.initials: YP
authors.lastname: Tsao
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D002455:Cell Division; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D016758:Genes, jun; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D015603:Keratinocytes / Q000378:metabolism; D009856:Oncogene Proteins, Viral / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology; D013539:Simian virus 40; D013449:Sulfonamides; D000086082:Viroporin Proteins
chemical_list: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D007546:Isoquinolines; D009856:Oncogene Proteins, Viral; D010879:Piperazines; D013449:Sulfonamides; C054859:oncogene protein E5, Human papillomavirus type 16; D000086082:Viroporin Proteins; C043204:N-(2-guanidinoethyl)-5-isoquinolinesulfonamide