[Acute porphyria and multiple organ failure during treatment with lamotrigine].
A 38-year-old female suffered from an acute porphyric attack, multi-organ failure and disseminated intravascular coagulation (DIC) within two weeks of starting lamotrigine, a new antiepileptic drug. The porphyric attack was characterized by excess urinary excretion of aminolevulinic acid (ALA), porphobilinogen (PBG) and coproporphyrin III, a pattern similar to that seen in hereditary coproporphyria, however the diagnostic criteria for this specific porphyria were not fulfilled. We suggest that the observed clinical picture represents a rare adverse reaction to lamotrigine.
Gregersen
H
H
Medicinsk-haematologisk afdeling, Arhus Amtssygehus.
Nielsen
J S
JS
Peterslund
N A
NA
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D009102:Multiple Organ Failure / Q000139:chemically induced*; D017118:Porphyria, Acute Intermittent / Q000139:chemically induced*; D014227:Triazines / Q000009:adverse effects*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine
Akut porfyri og multiorgansvigt under behandling med lamotrigin.