A possible non-aluminum oral phosphate binder? A comparative study on dietary phosphorus absorption.
The aim of this study was to highlight a possible new non-aluminum phosphate-binder to limit hyperphosphatemia in patients with renal failure. Lanthanum chloride hydrate was evaluated as a dietary phosphate binder in rats. Aluminum chloride hexahydrate was evaluated as a reference. Animals were divided in five groups (6 animals per group): 1 control group (C), 2 aluminum groups (Al1 and Al2), receiving different doses of aluminum chloride hexahydrate and 2 lanthanum groups (La1 and La2), receiving different doses of lanthanum chloride hydrate. During the treatment, urine and stools were collected. At the end of the treatment animals were sacrificed and plasma and different organs were collected (liver, spleen, kidneys, brain and femur). To highlight the possible transfer of lanthanum in rat tissues, a long-term (100 days) study was carried with a high dose. At the end of the treatment, lanthanum determinations were carried out on several tissues (liver, spleen, kidneys, brain, femur and lungs). Determinations of phosphorus and calcium levels in plasma indicated that lanthanum chloride hydrate showed as good results as aluminum chloride hexahydrate. Lanthanum chloride hydrate significantly (p < 0.01) reduced the bone phosphorus burden. Decreases of urinary excretion and increases in fecal excretion of phosphorus indicated a severe phosphorus depletion in all treatments (Al and La). Unfortunately, in the long-term study, lanthanum traces could only be determined in the different tissues but not in plasma. However, in comparison with the equivalent aluminum treatment, the transfer of lanthanum was less important than aluminum transfer. Consequently, lanthanum could provide a possible alternative to aluminum.
Graff
L
L
Laboratoire de Chimie Générale Appliquée à la Médecine, Faculté de Médecine, Université Henri Poincaré, Nancy I, Vandoeuvre les Nancy, France.
Burnel
D
D
D000284:Administration, Oral; D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000097:blood / Q000652:urine; D004032:Diet; D007811:Lanthanum / Q000378:metabolism*; D008297:Male; D008903:Minerals / Q000378:metabolism; D010758:Phosphorus / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D008903:Minerals; D010758:Phosphorus; D007811:Lanthanum; D000535:Aluminum; D002118:Calcium