Deliberate overdose of uranium: toxicity and treatment.
A case is described of deliberate ingestion of 15 g of uranium acetate which resulted in acute renal failure requiring dialytic therapy for 2 weeks, refractory anaemia, rhabdomyolysis, myocarditis, liver dysfunction with a disproportionate coagulopathy and paralytic ileus. Despite significant elevations in plasma uranium levels, treatment with both calcium EDTA and calcium DTPA were ineffective in promoting uranium excretion. Six months later the initial significant renal impairment exists with a persistent incomplete Fanconi syndrome. Future options for management of this unusual cause of acute renal failure are discussed.
Pavlakis
N
N
Department of Renal Medicine, Royal North Shore Hospital, Sydney, Australia.
Pollock
C A
CA
McLean
G
G
Bartrop
R
R
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy*; D000753:Anemia, Refractory / Q000139:chemically induced; D002614:Chelating Agents / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D062787:Drug Overdose; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000139:chemically induced; D009942:Organometallic Compounds / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000139:chemically induced; D014501:Uranium / Q000506:poisoning
D002614:Chelating Agents; D009942:Organometallic Compounds; C005460:uranyl acetate; D014501:Uranium