title: Comparison of surgical treatment of ulcerative colitis associated with primary sclerosing cholangitis: ileal pouch-anal anastomosis versus Brooke ileostomy.
abstract: OBJECTIVE
  To compare the operative risks, operative complications, and late outcome of two homogeneous groups of patients with chronic ulcerative colitis (CUC) and primary sclerosing cholangitis (PSC) who underwent either Brooke ileostomy or ileal pouch-anal anastomosis (IPAA).
  
  
  METHODS
  Between 1970 and 1990, 72 patients with CUC and PSC underwent proctocolectomy with either Brooke ileostomy (group I; N = 32) or IPAA (group II; N = 40). Postoperative data included operative mortality, need for blood transfusion, general postoperative complications, liver-related complications, and proctocolectomy-related complications.
  
  
  RESULTS
  Eight group I patients and nine group II patients had a total of 12 and 11 general complications, respectively. Liver-related complications were diagnosed in 16% and 10% of group I and group II patients, respectively. Proctocolectomy-specific complications occurred in 34% of group I and 20% of group II patients. The overall need for blood transfusion was 94% in group I and 47% in group II (P < 0.001). The cumulative probability of proctocolectomy-related complications at 5 years was 23% for group I and 64% for group II patients (P < 0.002). The difference, however, was primarily due to the high frequency of pouchitis after IPAA, estimated at 57% at 4 years. The cumulative 5-year risk of liver-related complications was 37% and 28% for group I and group II, respectively. Peristomal varices and bleeding occurred in eight group I patients but in none of group II.
  
  
  CONCLUSIONS
  Because IPAA avoids bleeding problems, it is the surgical treatment of choice in patients with PSC and CUC.
authors.affiliation: Department of Surgery, Mayo Clinic Rochester, MN 55905, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Kartheuser
authors.forename: R R
authors.initials: RR
authors.lastname: Dozois
authors.forename: N F
authors.initials: NF
authors.lastname: LaRusso
authors.forename: R H
authors.initials: RH
authors.lastname: Wiesner
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
authors.forename: C D
authors.initials: CD
authors.lastname: Schleck
mesh_terms: D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D015209:Cholangitis, Sclerosing / Q000401:mortality / Q000534:rehabilitation / Q000601:surgery*; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000401:mortality / Q000534:rehabilitation / Q000601:surgery*; D004932:Esophageal and Gastric Varices / Q000209:etiology; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects / Q000401:mortality / Q000534:rehabilitation; D008107:Liver Diseases / Q000209:etiology; D016015:Logistic Models; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects / Q000401:mortality / Q000534:rehabilitation; D011379:Prognosis; D016016:Proportional Hazards Models; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate; D014648:Varicose Veins / Q000209:etiology