[Functional significance of CD56 large granular lymphocytes in the decidua in early pregnancy in the human].
OBJECTIVE
The study was undertaken to characterize the large granular lymphocytes (LGL) found in large numbers in the decidua of early pregnancy, in order to investigate their functional significance in placentation.


METHODS
The LGL were investigated by immunohistochemical, flow cytometric and molecular biological techniques.


CONCLUSIONS
The LGL resemble a small subpopulation of Natural Killer cells (NK-cells) in the peripheral blood, express activation antigens and produce cytokines that may have a regulatory/modulatory influence on trophoblast growth.
Marzusch
K
K
Frauenklinik, Kinderklinik der Eberhard-Karls-Universität Tübingen.
Ruck
P
P
Handgretinger
R
R
Dietl
J
J
Horny
H P
HP
Kaiserling
E
E
D019002:CD56 Antigen / Q000032:analysis*; D016207:Cytokines / Q000378:metabolism; D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007694:Killer Cells, Natural / Q000276:immunology*; D010929:Placentation / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000276:immunology
D019002:CD56 Antigen; D016207:Cytokines
Zur funktionellen Bedeutung der CD56++ Large Granular Lymphocytes (LGL) in der Dezidua der Frühschwangerschaft beim Menschen.