Gametocytocidal activity of alpha/beta arteether by the oral route of administration.
Arteether (alpha/beta) (a mixture of alpha and beta enantioners) has been reported to possess gametocytocidal activity against Plasmodium cynomolgi B when the drug is given by the intramuscular route, but it would be preferable to use oral route therapy for gametocyte carriers. This is a report of a study of the gametocytocidal action of arteether administered by the oral route. The results indicate high levels of activity at 10 mg/kg in a single dose or in two divided doses when given orally.
Tripathi
R
R
Division of Microbiology, Central Drug Research Institute, Lucknow, India.
Dutta
G P
GP
Vishwakarma
R A
RA
D000284:Administration, Oral; D000818:Animals; D000852:Anopheles; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins; D004195:Disease Models, Animal; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D016789:Plasmodium cynomolgi / Q000187:drug effects* / Q000254:growth & development; D012717:Sesquiterpenes / Q000008:administration & dosage*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil