The response of mouse lymphosarcoma cells to continuous gamma irradiation.
Long-lasting survival of LS/BL tumor cells under continuous exposure in vivo to 60Co irradiation at an exposure rate of 10 cGy/h was observed. While LS/BL tumor cells tolerated the irradiation for more than 150 weeks, the number of hematopoietic stem cells decreased to less than 1% of control values within 7 days of irradiation. The liver colony method was used to develop sublines from nonirradiated and continuously (110 weeks) irradiated LS/BL cells for the analysis of karyotypes of the resulting clones of lymphosarcoma cells. The appearance of new structural abnormalities t(12:9) in one of the sublines tested correlated with its faster host killing when compared to the parent line.
Jurásková
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Research Institute of Child Health, Brno, Czech Republic.
Kozubek
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D000818:Animals; D002869:Chromosome Aberrations; D005260:Female; D005720:Gamma Rays; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011836:Radiation Tolerance