[Radiosensitivity and postradiation kinetics of megakaryocyte release of the bone marrow (analysis based on data of the Chernobyl AES accident sequelae)].
The radiosensitivity of cellular elements of megakaryocytic spring in accordance of their maturity has been evaluated on the basis of analysis of changes in thrombocyte level in peripheral blood of the Chernobyl disaster victims. The radiosensitivity of committed cellular elements of megakaryocytic spring by the criterion D0 is presumably 1.6-1.7 Gy(n = 1). More mature polyploid cells (megakaryoblasts, megakaryocytes) apparently are "absolutely" radioresistant and within the analysed range of doses (0.1-13.7 Gy) their function of thrombocyte producing remains intact. It has been proved that the rate of thrombocyte escape from peripheral blood rises with the acute radiation disease under going in the comparison with the norm that seriously affects the lifetime of thrombocytes. The transit time of megakaryocyte starting from primarily committed cell and ending with a cellular element, producing thrombocytes, is not a constant value. The normal transit time is approximately 28 days.
Gruzdev
G P
GP
Chistopol'skiĭ
A S
AS
Suvorova
L A
LA
D001792:Blood Platelets / Q000528:radiation effects*; D006801:Humans; D007700:Kinetics; D008533:Megakaryocytes / Q000502:physiology / Q000528:radiation effects*; D008954:Models, Biological; D011210:Power Plants; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000097:blood*; D011836:Radiation Tolerance; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine
Radiochuvstvitel'nost' i postradiatsionnaia kinetika megakariotsitarnogo rostka kostnogo mozga (analiz po dannym posledstviĭ avarii na ChAES).