title: Accumulation of arsenic species in serum of patients with chronic renal disease.
abstract: Speciation of arsenic was determined in serum of 19 non-hemodialysis (non-HD) and 18 HD patients. The respective mean values of serum creatinine in these groups were 410 +/- 250 and 914 +/- 173 mumol/L (reference range for healthy subjects: females 50-80; males 57-93 mumol/L). The mean total arsenic concentrations were 5.12 +/-5.58 and 6.47 +/- 4.28 micrograms/L, respectively (reference value: 0.958 +/-1.52 micrograms/L). Dimethylarsinic acid (DMA) and arsenobetaine (AsB) were the major As species in serum of the non-HD and HD patients, with mean values of 0.82 +/- 1.05 and 1.93 +/- 1.51 micrograms/L for DMA and 3.55 +/- 4.58 and 3.47 +/- 2.89 micrograms/L for AsB, respectively. Serum concentrations of inorganic As and monomethylarsonic acid in both groups were below the detection limits for these compounds. Measurement of As concentration before vs after 4 h of HD treatment indicated that 68% of total As in serum was removed, as was 16% of the total As in packed cells. The efficiency of DMA and AsB removal during dialysis corresponded to that of total As.
authors.affiliation: Laboratory for Analytical Chemistry, University of Gent, Belgium.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Cornelis
authors.forename: J
authors.initials: J
authors.lastname: De Kimpe
authors.forename: L
authors.initials: L
authors.lastname: Mees
authors.forename: V
authors.initials: V
authors.lastname: Vanderbiesen
authors.forename: A
authors.initials: A
authors.lastname: De Cubber
authors.forename: R
authors.initials: R
authors.lastname: Vanholder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001151:Arsenic / Q000097:blood*; D001152:Arsenicals / Q000097:blood; D002101:Cacodylic Acid / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D006435:Renal Dialysis; D012680:Sensitivity and Specificity
chemical_list: D001152:Arsenicals; D002101:Cacodylic Acid; D003404:Creatinine; D001151:Arsenic; C038992:arsenobetaine