title: [Interferon alpha in the treatment of chronic hepatitis B in children].
abstract: Nine children suffering from chronic hepatitis due to hepatitis B virus (HBV) infection were treated with recombinant IFN-alpha-2C for 16 weeks. Replication of HBV was inhibited in 5 cases while a decreased inflammatory process in the liver was attained in 3. The treatment was very well tolerated in all of the studied children. A significant increase of ALT activity in the fourth week of treatment seems to be a positive prognostic factor.
authors.affiliation: Klinika Obserwacyjno-Zakaźna Instytutu Pediatrii Akademii Medycznej w Poznaniu.
authors.forename: J
authors.initials: J
authors.lastname: Wysocki
authors.forename: W
authors.initials: W
authors.lastname: Słuzewski
authors.forename: A
authors.initials: A
authors.lastname: Kowala-Piaskowska
authors.forename: W
authors.initials: W
authors.lastname: Biczysko
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D016898:Interferon-alpha
vernacular_title: Interferon alfa (IFN-alpha) w leczeniu przewlekłego zapalenia watroby typu B u dzieci.