2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.
Giardina
G A
GA
Department of Chemistry, SmithKline Beecham S.p.A., Milano, Italy.
Sarau
H M
HM
Farina
C
C
Medhurst
A D
AD
Grugni
M
M
Foley
J J
JJ
Raveglia
L F
LF
Schmidt
D B
DB
Rigolio
R
R
Vassallo
M
M
Vecchietti
V
V
Hay
D W
DW
D000818:Animals; D001667:Binding, Competitive; D016466:CHO Cells; D002924:Ciliary Body / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D015195:Drug Design; D006168:Guinea Pigs; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D010446:Peptide Fragments / Q000037:antagonists & inhibitors; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D011817:Rabbits; D018042:Receptors, Neurokinin-3 / Q000037:antagonists & inhibitors*; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors
D010446:Peptide Fragments; D010880:Piperidines; D011804:Quinolines; D018042:Receptors, Neurokinin-3; D011993:Recombinant Fusion Proteins; C054724:senktide; D013373:Substance P; C091554:SR 142801