title: Laparoscopic aortic replacement in the porcine model: a feasibility study in preparation for laparoscopically assisted abdominal aortic aneurysm repair in humans.
abstract: BACKGROUND
  Current laparoscopic vascular techniques have centered around aortofemoral bypass for the treatment of patients with aortic occlusive disease. However, the majority of aortic surgeries are performed for the treatment of aortic aneurysmal disease. With this mind, we undertook this study to assess the feasibility of laparoscopic aortic replacement in the porcine model in preparation for laparoscopically assisted abdominal aortic aneurysm (AAA) repair in humans.
  
  
  METHODS
  Twenty-three female pigs weighing between 35 and 40 kg underwent laparoscopic aortic dissection by either a transabdominal or retroperitoneal approach. The infrarenal aorta was laparoscopically dissected, isolated, and cross clamped. Then a custom designed cuffed polytetrafluoroethylene graft was inserted. After reestablishing and confirming distal flow, the animals were sacrificed.
  
  
  RESULTS
  Fifteen functioning aortic grafts were placed in 21 animals who had the transabdominal approach. One functioning graft was placed in the retroperitoneal group. Complications included bladder, ureteral, inferior vena cava, renal vein, and aortic injuries. By the end of the study, the operative time was reduced from six to less than two hours; blood loss was reduced from 1,000 to 150 mL; and cross-clamping time was reduced from 60 to 15 minutes.
  
  
  CONCLUSIONS
  In the porcine model, laparoscopic abdominal aortic replacement is associated with a significant learning curve. However, this method of repair is technically feasible and warrants further investigation in the treatment of AAA in humans.
authors.affiliation: Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: E A
authors.initials: EA
authors.lastname: Murphy
authors.forename: J
authors.initials: J
authors.lastname: Levison
authors.forename: J R
authors.initials: JR
authors.lastname: Cohen
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D002983:Clinical Competence; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005260:Female; D010535:Laparoscopy; D011183:Postoperative Complications; D011677:Punctures; D013552:Swine