title: [The study of the evolution of laryngeal premalignant lesions].
abstract: Hyperkeratosis of the laryngeal epithelium is considered a clinically premalignant lesion that develops into invasive carcinoma in about 7-20% of cases. We reviewed 125 cases of patients with laryngeal keratosis in biopsy obtained by direct laryngocopy over a 10-year period. The evolution of these lesions to malignancy was conditioned by age, the presence of atypias in the initial lesions, and smoking; smoking is a modifiable factor. Surgery is the treatment of choice, with periodic follow-up for three to five years. The literature was reviewed.
authors.affiliation: Servicio de ORL, Hospital Nuestra Señora de Aránzazu, San Sebastián (Guipúzcoa).
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez García
authors.forename: M A
authors.initials: MA
authors.lastname: Landa Aranzábal
authors.forename: A
authors.initials: A
authors.lastname: Rivas Salas
authors.forename: M
authors.initials: M
authors.lastname: Abrego Olano
authors.forename: J
authors.initials: J
authors.lastname: Algaba Guimera
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007642:Keratosis / Q000503:physiopathology* / Q000601:surgery; D007828:Laryngoscopy; D007830:Larynx / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D007971:Leukoplakia / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects
vernacular_title: Estudio evolutivo de lesiones premalignas laríngeas.