Fc gamma RII-mediated regulation of human B cells.
Recent studies have provided considerable insight into the mechanism of BCR-mediated B-cell activation, but the inhibitory signals transferred by Fc gamma Rs leading to down-regulation of BCR-activated B lymphocytes are not clarified yet. In the present paper the authors give an overview on new findings regarding BCR structure and signal transduction mechanisms induced by the B-cell antigen receptor complex and outline, partly based on their own observations, the possible mechanisms resulting in Fc gamma R-mediated inhibition of B cells.
Gergely
J
J
Department of Immunology, Eötvös Loránd University, Göd, Hungary.
Sármay
G
G
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D017452:Receptors, IgG / Q000502:physiology*
D011947:Receptors, Antigen, B-Cell; D017452:Receptors, IgG