title: [The antioxidant therapy of cholestatic liver depression in diabetics].
abstract: Lipid peroxidation of cell membranes and liquid media of the organism were studied in 54 diabetics with the cholestatic syndrome, and fundamentals of antioxidant therapy of this cohort of patients discussed. The predominant efficacy of bio-oxidants has been revealed. The mechanism of their action is realized primarily at the stages of initiation and ramification of the chain of free radical oxidation. The authors searched for a sufficiently effective combination of antioxidants for the treatment of medium-severe and grave hepatodepression in patients with sub- and decompensated diabetes mellitus, as well as for the optimal method of antioxidant therapy.
authors.forename: A L
authors.initials: AL
authors.lastname: Gushcha
authors.forename: S V
authors.initials: SV
authors.lastname: Tarasenko
authors.forename: A V
authors.initials: AV
authors.lastname: Fedoseev
authors.forename: S N
authors.initials: SN
authors.lastname: Sokolova
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002779:Cholestasis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D015227:Lipid Peroxidation; D017093:Liver Failure / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D000975:Antioxidants
vernacular_title: Antioksidantnaia terapiia kholestaticheskoĭ gepatodepressii u bol'nykh sakharnym diabetom.