title: Boromycin, an anti-HIV antibiotic.
abstract: The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.
authors.affiliation: Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kohno
authors.forename: T
authors.initials: T
authors.lastname: Kawahata
authors.forename: T
authors.initials: T
authors.lastname: Otake
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: N
authors.initials: N
authors.lastname: Ueba
authors.forename: M
authors.initials: M
authors.lastname: Nishio
authors.forename: A
authors.initials: A
authors.lastname: Kinumaki
authors.forename: S
authors.initials: S
authors.lastname: Komatsubara
authors.forename: K
authors.initials: K
authors.lastname: Kawashima
mesh_terms: D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001881:Borates / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D016264:Dextran Sulfate / Q000494:pharmacology; D005944:Glucosamine / Q000031:analogs & derivatives / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D012194:RNA-Directed DNA Polymerase / Q000187:drug effects / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D001881:Borates; D017485:1-Deoxynojirimycin; C000302:boromycin; D016264:Dextran Sulfate; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase; D006026:Glycoside Hydrolases; D005944:Glucosamine; C013626:nojirimycin