The effect of intermittent steroid therapy on anti-sperm antibody levels.
Sperm-bound antisperm antibody levels were measured in 10 males in subfertile partnerships who were treated with high dose intermittent prednisolone therapy over a period up to 9 months. Antibody levels fell in all patients during therapy, although a transient rise occurred after 2-4 months. There were low treatment complication rates. Four pregnancies occurred during the treatment of the 10 patients. There was no correlation between pregnancy and change in antibody.
Keane
D
D
Department of Zoology, University College Cork, Ireland.
Jenkins
D M
DM
Higgins
T
T
O'Neill
M
M
Mulcahy
M F
MF
Ferriss
J B
JB
D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000378:metabolism; D007074:Immunoglobulin G / Q000032:analysis / Q000378:metabolism; D007075:Immunoglobulin M / Q000032:analysis / Q000378:metabolism; D007248:Infertility, Male / Q000188:drug therapy* / Q000276:immunology*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011241:Prednisone