Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
The sulfated flavonoids in Polygonum hydropiper showed potent inhibiton against lens aldose reductase. Among these flavonoids isorhamnetin 3,7-disulfate (5) was most potent. Kinetic analysis showed that 5 exhibited noncompetitive inhibition against both dl-glyceraldehyde and NADPH.
Haraguchi
H
H
Faculty of Engineering, Fukuyama University, Japan.
Ohmi
I
I
Sakai
S
S
Fukuda
A
A
Toihara
Y
Y
Fujimoto
T
T
Okamura
N
N
Yagi
A
A
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology; D007908:Lens, Crystalline / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D013552:Swine
D004791:Enzyme Inhibitors; D005419:Flavonoids; D000449:Aldehyde Reductase; D009247:NADH, NADPH Oxidoreductases