Two new taxoids from the stem bark of Taxus baccata.
Two new taxoids, 13-deoxo-13 alpha-acetyloxy-7 beta,9 alpha-diacetyl-1,2-dideoxytaxine B[1] and 7 beta-xylosyl-10-deacetyltaxol D [7], were isolated from the stem bark of Taxus baccata cv. stricta. Their structures were elucidated using spectroscopic methods and their bioactivity was evaluated using an in vitro microtubule assembly assay.
Guo
Y
Y
Pharmaceutical Institute, Université Libre de Bruxelles, Belgium.
Diallo
B
B
Jaziri
M
M
Vanhaelen-Fastré
R
R
Vanhaelen
M
M
Ottinger
R
R
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013552:Swine; D043823:Taxoids; D014404:Tubulin / Q000096:biosynthesis
C100477:13-deoxo-13-acetyloxy-7,9-diacetyl-1,2-dideoxytaxine; C100478:7-xylosyl-10-deacetyltaxol; D043823:Taxoids; D014404:Tubulin; D017239:Paclitaxel