Calcium alpha-ketoglutarate administration to malnourished hemodialysis patients improves plasma arginine concentrations.
Calcium alpha-ketoglutarate administration to 24 malnourished hemodialysis patients for 1 year leads to a significant increase in plasma concentrations of L-arginine from 53.6 +/- 18.3 (compared to a healthy control group: 87.5 +/- 27.3) to 71.1 +/- 15.9 mumol/l (p < 0.05). Furthermore, concentrations in plasma of proline and histidine, precursors of glutamate biosynthesis, are increased; inorganic phosphate and urea are significantly decreased in hemodialysis patients after 1 year of calcium alpha-ketoglutarate administration.
Riedel
E
E
Institut für Biochemie, Freie Universität Berlin, Deutschland.
Hampl
H
H
Steudle
V
V
Nündel
M
M
D000328:Adult; D000368:Aged; D001120:Arginine / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D018698:Glutamic Acid / Q000096:biosynthesis; D006639:Histidine / Q000097:blood; D006801:Humans; D007656:Ketoglutaric Acids / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000209:etiology / Q000517:prevention & control*; D010710:Phosphates / Q000097:blood; D011392:Proline / Q000097:blood; D012016:Reference Values; D006435:Renal Dialysis; D013997:Time Factors; D014508:Urea / Q000097:blood
D007656:Ketoglutaric Acids; D010710:Phosphates; D018698:Glutamic Acid; D006639:Histidine; D014508:Urea; D001120:Arginine; D011392:Proline