title: [111In-labeled leukocyte scintigraphy in patients with inflammation of unknown focus].
abstract: This study evaluates the usefulness of 111In-labeled leukocyte scintigraphy to localize inflammatory foci that cannot be determined by clinical symptoms and other imaging studies. Patients with persistent fever following abdominal surgery (n = 20), suspected post-traumatic osteomyelitis associated with multiple fractures (n = 5), and fever of unknown origin (n = 22) were recruited. In all patients, the exact location of inflammatory foci could not be determined by clinical symptoms and conventional imaging studies. In patients with post-surgical fever, leukocyte scintigraphy localized responsible foci in 65% of patients and provided clinically useful information for the treatment. In patients with multiple fractures, the location of osteomyelitis was diagnosed confidently in only one case (20%). In patients with fever of unknown origin, responsible foci were detected in 18% of patients. Although in those patients positive leukocyte studies provided clinically useful information, overall usefulness seemed to be limited. Leukocyte scintigraphy is able to detect inflammatory foci in patients with post-surgical fever, but less likely to localize responsible foci for post-traumatic osteomyelitis or fever of unknown origin when patients have been examined carefully by clinical symptoms and conventional imaging studies.
authors.affiliation: Department of Radiology, Chiba University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: J
authors.initials: J
authors.lastname: Kuyama
authors.forename: N
authors.initials: N
authors.lastname: Matsuno
authors.forename: K
authors.initials: K
authors.lastname: Uno
authors.forename: Y
authors.initials: Y
authors.lastname: Kitakata
authors.forename: H
authors.initials: H
authors.lastname: Kitahara
mesh_terms: D018784:Abdominal Abscess / Q000000981:diagnostic imaging; D000038:Abscess / Q000000981:diagnostic imaging; D000328:Adult; D005260:Female; D005335:Fever of Unknown Origin / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D007249:Inflammation / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes