title: [Lung disease induced by isotretinoin].
abstract: A young man without any past history of note had taken isotretinoin for disfiguring acne before the summer season. He presented with a severe bilateral pneumonia, associated with dyspnoea two months after the start of treatment. On the pulmonary radiography there was a bilateral ground glass appearance which was worse on the right. The elevated level of eosinophils (54% in 564,000 cells/ml) in the alveolar lavage lead to a diagnosis of allergic pneumonia. The rapidly favourable outcome following the cessation of the medication and with the addition of corticosteroids seemed to us a supplementary argument in favour of a diagnosis of eosinophilic pneumonia, due to isotretinoin which seemed the primary initiating factor.
authors.affiliation: Service de Pneumologie et Médecine Interne, CHG Longjumeau.
authors.forename: G
authors.initials: G
authors.lastname: Oliviero
authors.forename: P
authors.initials: P
authors.lastname: Constans
authors.forename: I
authors.initials: I
authors.lastname: Caby
authors.forename: P
authors.initials: P
authors.lastname: De Rohan Chabot
authors.forename: J C
authors.initials: JC
authors.lastname: Lacherade
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D015474:Isotretinoin / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D007641:Keratolytic Agents; D015474:Isotretinoin; D006854:Hydrocortisone; D008775:Methylprednisolone
vernacular_title: Pneumopathie induite par l'isotrétinoïne.