cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.
Kipreos
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ET
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Lander
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Wing
J P
JP
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WW
Hedgecock
E M
EM
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000196:embryology / Q000235:genetics*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D044842:Cullin Proteins; D018076:DNA, Complementary / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics*; D005855:Germ Layers; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007814:Larva; D008969:Molecular Sequence Data; D009154:Mutation; D018510:RNA, Helminth / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D015003:Yeasts
D018797:Cell Cycle Proteins; C100318:Cullin 1; D044842:Cullin Proteins; D018076:DNA, Complementary; D015801:Helminth Proteins; D018510:RNA, Helminth; D012333:RNA, Messenger