[Selection of drugs for chemotherapy based on drug resistance marker].
There is no appropriate tumor marker for the selection of anti cancer drug. Some agents can be selected for the reversal of anti cancer drug resistance. For example, verapamil or cyclosporin A may be useful for p-glycoprotein related multidrug resistance, and amphotericin B, docosahexaenoic acid or 8-chloro cAMP can be used for the modification of cisplatin-resistance. Recently, bcl-2 or mutated p53 gene are demonstrated to be important markers for drug resistance. More studies are necessary to identify an appropriate markers for drug resistance and overcome it.
Fukumoto
H
H
Pharmacology Division, National Cancer Center Research Institute.
Saijo
N
N
D014408:Biomarkers, Tumor / Q000032:analysis*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans
D014408:Biomarkers, Tumor