title: Genetics of autoimmune disease.
abstract: In the past year, the major advances in understanding the genetics of autoimmune disease in both man and mouse have been made as a result of using the positional cloning approach. Construction of congenic mouse strains, and, in humans, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.
authors.affiliation: University of Oxford, UK.
authors.forename: T R
authors.initials: TR
authors.lastname: Merriman
authors.forename: J A
authors.initials: JA
authors.lastname: Todd
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D004195:Disease Models, Animal; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D011971:Receptors, Immunologic / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D011971:Receptors, Immunologic