title: The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
abstract: The effects of agonists for delta-opioid receptors on synaptic transmission in hamster submandibular ganglion were studied in vitro, using an intracellular recording technique. [Met5]enkephalinamide (17 microM), [D-Ser2¿Leu-enkephalin-Thr (14 microM) and [D-Pen2, D-Pen5]enkephalin (10 microM), delta selective agonists caused reversible depression of the fast EPSP amplitude in 10 of 30 cells tested. The inhibitory actions of [D-Pen2, D-Pen5]enkephalin were antagonized by ICI 174,864, a delta selective antagonist. Naloxon a non-selective antagonist and ICI 174,864 both also potentiated the fast EPSP amplitude in 5 of 11 cells tested.
authors.affiliation: Department of Physiology, Tokyo Dental College, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Endoh
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D020881:Enkephalin, D-Penicillamine (2,5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives; D004745:Enkephalins / Q000494:pharmacology*; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005731:Ganglionic Stimulants / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D017465:Receptors, Opioid, delta / Q000819:agonists*; D013363:Submandibular Gland / Q000294:innervation*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
chemical_list: D004745:Enkephalins; D005731:Ganglionic Stimulants; D009292:Narcotic Antagonists; D017465:Receptors, Opioid, delta; D009270:Naloxone; D004246:Dimethylphenylpiperazinium Iodide; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; C021055:Met-enkephalinamide; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; D020881:Enkephalin, D-Penicillamine (2,5)-; C040643:N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine