title: T cell receptor V-segment frequencies in aged individuals.
abstract: The T V alpha and V beta cell specificities repertoire usage in aging subjects was studied by the use of seven different monoclonal antibodies specific for defined regions of the T cell receptor (TCR). Except for the V beta 8 subfamily, no differences were observed in the frequency of T cells bearing selected V alpha beta epitopes, between old and control subjects.
authors.affiliation: Department of Physiology, School of Medicine, Universidad del País Vasco, Bilbao, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
authors.forename: B
authors.initials: B
authors.lastname: Esparza
authors.forename: M
authors.initials: M
authors.lastname: Barranquero
authors.forename: E
authors.initials: E
authors.lastname: Sabino
authors.forename: F
authors.initials: F
authors.lastname: Merino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000939:Epitopes / Q000032:analysis; D005260:Female; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008297:Male; D008875:Middle Aged; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D013030:Spain; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D016693:Receptors, Antigen, T-Cell, alpha-beta