title: Safety and effectiveness of an acellular pertussis vaccine in subjects with Down's syndrome.
abstract: We evaluated the reactogenicity and immunogenicity of an acellular pertussis vaccine in 24 subjects affected by Down's syndrome and in 10 normal infants. Neither general nor local adverse reactions were observed in either group of subjects. The new acellular vaccine administration elicited protective levels of antibodies in all the subjects with Down's syndrome, although the geometric mean titres of IgG antibodies against Bordetella pertussis in these subjects were significantly lower than in normal controls.
authors.affiliation: Pediatric Clinic, University of Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Li Volti
authors.forename: T
authors.initials: T
authors.lastname: Mattina
authors.forename: L
authors.initials: L
authors.lastname: Mauro
authors.forename: S
authors.initials: S
authors.lastname: Bianca
authors.forename: S
authors.initials: S
authors.lastname: Anfuso
authors.forename: A
authors.initials: A
authors.lastname: Ursino
authors.forename: F
authors.initials: F
authors.lastname: Mollica
mesh_terms: D000917:Antibody Formation; D001886:Bordetella pertussis / Q000276:immunology; D002675:Child, Preschool; D004314:Down Syndrome; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D010567:Pertussis Vaccine / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D007074:Immunoglobulin G; D010567:Pertussis Vaccine