[Prognostic factors of colorectal cancer concerning metastases].
Four prognostics factors were investigated for colorectal cancer metastases. 1) There were statistically more venous invasions using Victoria blue elastic staining in patients with liver or lymph node metastasis than in those without metastasis. 2) The immunohistochemical expression rate of c-erbB-2 in liver metastasis cases was 27%, which was significantly higher than 3% in no metastasis cases. 3) Sialyl Lewis x (SLex) is related with cell adhesion. SLex positive rates in vessel invasion cancer cells were 71.4% with metastasis and 31.0% without metastasis. 4) Matrilysin is one of MMPs and it was significantly increased with Dukes stage by fluorescence intensity.
Yamaguchi
S
S
Second Department of Surgery, Yokohama City University, Japan.
Ichikawa
Y
Y
Tanaka
K
K
Ishikawa
T
T
Masui
H
H
Koganei
K
K
Eguchi
K
K
Ike
H
H
Ohki
S
S
Shimada
H
H
D015179:Colorectal Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D016256:Lewis X Antigen / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D020783:Matrix Metalloproteinase 7; D008666:Metalloendopeptidases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D014680:Veins / Q000473:pathology
D016256:Lewis X Antigen; D020783:Matrix Metalloproteinase 7; D008666:Metalloendopeptidases; D018719:Erb-b2 Receptor Tyrosine Kinases