Intracoronary thrombolysis in the treatment of graft closure immediately after CABG.
A patient with a hypercoagulable state underwent coronary artery bypass grafting and was recovering uneventfully until diffuse electrocardiographic changes and cardiogenic shock developed within hours of the operation. Because of severe hemodynamic compromise on high-dose inotropic drugs and intraaortic balloon pump support, she was taken to the catheterization laboratory, where the patient was discovered to have thrombotic occlusion of all grafts, including the left internal mammary artery to the left anterior descending artery. Multiple graft percutaneous transluminal coronary angioplasty and thrombolysis with urokinase successfully opened the grafts, without bleeding complication. Anastomoses were all free of significant anatomic lesion. She has remained free of cardiac symptoms for 3.5 years after operation.
Dauerman
H L
HL
Department of Medicine, Beth Israel Hospital, Boston, MA 02215, USA.
Cutlip
D E
DE
Sellke
F W
FW
D015906:Angioplasty, Balloon, Coronary; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D001026:Coronary Artery Bypass; D005175:Factor XII Deficiency / Q000150:complications; D005260:Female; D006083:Graft Occlusion, Vascular / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D010960:Plasminogen Activators / Q000008:administration & dosage*; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D017152:Antibodies, Antiphospholipid; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator