Proteodermatan and proteokeratan sulfate (decorin, lumican/fibromodulin) proteins are horseshoe shaped. Implications for their interactions with collagen.
The small proteoglycans proteodermatan and proteokeratan sulfates organize collagen fibrils in extracellular matrix [Scott, J. E. (1992) FASEB J. 6, 2639-2645], thus helping to maintain tissue shape. Their interaction with fibrils is probably via the protein. They have been examined by rotary shadowing-electron microscopy, which showed that these leucine-rich-repeat proteins are horseshoe shaped. Morphometry and comparison with polypeptide sequences suggest ways in which decorin could interact with tissue collagen fibrils. It is proposed that decorin is a bidentate ligand attached to two parallel neighboring collagen molecules in the fibril, helping to stabilize fibrils and orient fibrillogenesis.
Scott
J E
JE
Department of Chemical Morphology, School of Biological Sciences, Manchester University, U.K.
D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D002352:Carrier Proteins / Q000378:metabolism / Q000648:ultrastructure; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism / Q000648:ultrastructure; D003094:Collagen / Q000378:metabolism; D058575:Decorin; D003871:Dermatan Sulfate / Q000031:analogs & derivatives / Q000378:metabolism / Q000648:ultrastructure; D016326:Extracellular Matrix Proteins; D000071235:Fibromodulin; D007632:Keratan Sulfate / Q000378:metabolism / Q000648:ultrastructure; D000071234:Lumican; D008854:Microscopy, Electron; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011509:Proteoglycans / Q000378:metabolism / Q000648:ultrastructure*; D012091:Repetitive Sequences, Nucleic Acid; D016626:Shadowing Technique, Histology
D002352:Carrier Proteins; D011508:Chondroitin Sulfate Proteoglycans; D058575:Decorin; D016326:Extracellular Matrix Proteins; D000071234:Lumican; D011509:Proteoglycans; C028774:proteodermatan sulfate; D000071235:Fibromodulin; D003871:Dermatan Sulfate; D003094:Collagen; D007632:Keratan Sulfate