Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver.
The state of DNA methylation in the c-fos gene was examined in human livers of different ages, cirrhosis and hepatocellular carcinoma. The degree of methylation in the intron 1 to exon 4 region increased with age, whereas all of the 10 cirrhosis samples revealed a decrease in methylation when compared to normal livers of similar ages. The 11 hepatocellular carcinomas showed varied alterations suggesting that the alteration of the c-fos gene methylation is related to aging as well as to early-step of hepatocarcinogenesis.
Choi
E K
EK
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Uyeno
S
S
Nishida
N
N
Okumoto
T
T
Fujimura
S
S
Aoki
Y
Y
Nata
M
M
Sagisaka
K
K
Fukuda
Y
Y
Nakao
K
K
Yoshimoto
T
T
Kim
Y S
YS
Ono
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000378:metabolism*; D005260:Female; D016762:Genes, fos; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008745:Methylation; D008875:Middle Aged
D004247:DNA