Pentobarbital differentially inhibits N-methyl-D-aspartate and kainate-stimulated [3H]noradrenaline overflow in rat cortical slices.
1. This study examined the ability of pentobarbital to inhibit NMDA and kainate-stimulated [3H]noradrenaline ([3H]NA) overflow in rat brain cortical slices. 2. Pentobarbital inhibited NMDA-evoked [3H]NA overflow at 100 microM and greater and inhibited kainate-evoked [3H]NA overflow at 10 microM and greater. 3. The ability of pentobarbital to inhibit concentration-response curves for NMDA and kainate-evoked overflow of [3H]NA were also examined. Pentobarbital (300 microM) caused a 20% reduction in NMDA and a 50% reduction in kainate-induced maximal responses.
Brown
L M
LM
College of Medicine, Northeastern Ohio Universities, Rootstown 44272, USA.
D000316:Adrenergic alpha-Agonists / Q000378:metabolism; D000818:Animals; D018690:Excitatory Amino Acid Agonists; D018757:GABA Modulators / Q000494:pharmacology*; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D009638:Norepinephrine / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000316:Adrenergic alpha-Agonists; D018690:Excitatory Amino Acid Agonists; D018757:GABA Modulators; D016202:N-Methylaspartate; D010424:Pentobarbital; D007608:Kainic Acid; D009638:Norepinephrine