title: Leukocyte adhesion deficiency: report of a case and review of the literature.
abstract: Leukocyte adhesion deficiency (LAD) is a rare inherited immunodeficiency that is characterized by deficiency of the beta 2 integrin leukocyte adhesion molecules Mac-1, LFA-1, and p150,95. We describe a case of the severe form of LAD in an infant with recurrent infections and with a complete deficiency of beta 2 integrin molecules, and review the clinical aspects of the syndrome.
authors.affiliation: Department of Pediatrics, Fairfax Hospital for Children, Falls Church, Virginia, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Lipnick
authors.forename: A
authors.initials: A
authors.lastname: Iliopoulos
authors.forename: K
authors.initials: K
authors.lastname: Salata
authors.forename: J
authors.initials: J
authors.lastname: Hershey
authors.forename: D
authors.initials: D
authors.lastname: Melnick
authors.forename: G C
authors.initials: GC
authors.lastname: Tsokos
mesh_terms: D018821:CD18 Antigens / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D010375:Pedigree
chemical_list: D018821:CD18 Antigens; D015815:Cell Adhesion Molecules