title: Severe necroziting vasculitis in a patient with hepatitis C virus infection treated by interferon.
abstract: We report a case of polyarteritis nodosa occurring in a patient with hepatitis C, ten days after the beginning of alpha-IFN therapy. There was no cryoglobulinemia. Serum HCV-RNA was detectable before INF therapy and disappeared during the vasculites. The patient received boli of methylprednisolone and the neurological and skin lesions regressed after 5 months. This observation could suggest a precocious response to alpha-INF and a relationship between INF and the occurrence of vasculites.
authors.affiliation: Services d'Hepatogastroentérologie, Hôpital Jean Verdier, Bondy, France.
authors.forename: D
authors.initials: D
authors.lastname: Pateron
authors.forename: O
authors.initials: O
authors.lastname: Fain
authors.forename: J
authors.initials: J
authors.lastname: Sehonnou
authors.forename: J C
authors.initials: JC
authors.lastname: Trinchet
authors.forename: M
authors.initials: M
authors.lastname: Beaugrand
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000209:etiology*
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha