A nonbalanced translocation (10;16) demonstrated by FISH analysis in a case of alveolar adenoma of the lung.
Short-term cultures from an alveolar adenoma of the lung were cytogenetically examined. Of the 54 metaphases studied, 44 were characterized by an apparently normal karyotype and 10 showed a pseudodiploid karyotype: 46,XX,add(16)(q24). Fluorescence in situ hybridization studies permitted identification of the add(16)(q24) as a der(16)t(10;16)(q23;q24). This is the first report of a chromosomal aberration in an alveolar adenoma of the lung.
Roque
L
L
CIPM-Portuguese Cancer Institute, Lisbon, Portugal.
Oliveira
P
P
Martins
C
C
Carvalho
C
C
Serpa
A
A
Soares
J
J
D000236:Adenoma / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D002885:Chromosomes, Human, Pair 16; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged; D011650:Pulmonary Alveoli; D014178:Translocation, Genetic