[The correlation of the behavioral, bioelectrical and cytobiochemical characteristics of the effect of taftsin].
The complex neurophysiological, biochemical, and histochemical investigation carried out in dogs, cats, rabbits, and rats revealed the effects of taftsin (300 mcg/kg) at the macro- and microlevels within different periods (30 and 75 min) after its intraperitoneal injection. It was shown that after taftsin administration the configuration of evoked potentials was modified, especially, in the visual cortex and the nucleus accumbens. The absolute power of EEG spectra increased in a wide range of brain structures under consideration. Catecholaminergic activity was augmented and serotonin activity suppressed in the sensorimotor cortex and caudate nucleus, the indices of the protein metabolism reciprocally changed in the cortical and subcortical structures. Comparison of taftsin effects at different levels suggests that such effects are mainly caused by the interaction between the dopamine-containing brain structures. The consequence of taftsin administration can be probably interpreted as an intervention into the processes of visual perception.
Popova
N S
NS
Gershteĭn
L M
LM
Dovedova
E L
EL
Kachalova
L M
LM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006651:Histocytochemistry; D008297:Male; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014405:Tuftsin / Q000494:pharmacology*
D014405:Tuftsin
Sootnoshenie povedencheskikh, bioélektricheskikh i tsitobiokhimicheskikh kharakteristik éffekta taftsina.