title: Validation of a scoring method predicting the in-vitro fertilizing ability of human spermatozoa.
abstract: The fertilizing ability of human spermatozoa depends upon numerous functions such as motility, normal morphology, ability to bind to the zona pellucida and to undergo the acrosome reaction. Hence a lot of tests have been developed to try and predict IVF results. In a previous study we had established a scoring method, based on parameters such as sperm morphology, vitality, motility and the acrosome reaction, which was able to predict up to 83% of in-vitro fertilization results. The present study aimed to validate this score on a separate set of sperm samples. The results confirmed those of the first series. The score allowed prediction of fertilization failures with a 56% sensitivity, a 91% specificity, a 56% positive predictive value and a 91% negative predictive value. Therefore, this score could be used routinely to choose between conventional IVF and ICSI.
authors.affiliation: Centre Hospitalier Universitaire La Grave, Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Parinaud
authors.forename: G
authors.initials: G
authors.lastname: Richoilley
authors.forename: P
authors.initials: P
authors.lastname: Milhet
authors.forename: H
authors.initials: H
authors.lastname: Moutaffian
authors.forename: G
authors.initials: G
authors.lastname: Vieitez
mesh_terms: D000177:Acrosome / Q000502:physiology; D005298:Fertility; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D016015:Logistic Models; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000166:cytology / Q000502:physiology*