title: Colony stimulating factor-1 expression is developmentally regulated in the mouse.
abstract: Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF-1 plays a role in the perinatal development of these cells, CSF-1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF-1 concentrations rose in liver, kidney, and lung, declined in brain and serum, and did not change in intestine and heart. Concurrently, fetal/neonatal CSF-1 concentrations were higher in liver, kidney, and serum and lower in lung, brain, intestine, and heart than maternal tissue/serum concentrations, which showed no correlations with gestational or postpartum stage. CSF-1 mRNA was detected in all tissues examined and its expression increased in lung and heart and decreased in brain with increasing fetal/neonatal age. The developmental regulation of mouse CSF-1 expression appears to he important for mononuclear phagocyte development during this period.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, New York, USA.
authors.forename: P
authors.initials: P
authors.lastname: Roth
authors.forename: E R
authors.initials: ER
authors.lastname: Stanley
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005333:Fetus / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D016173:Macrophage Colony-Stimulating Factor / Q000032:analysis* / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D012333:RNA, Messenger; D016173:Macrophage Colony-Stimulating Factor