[Studies of drugs for osteoporosis (3): synthesis of quinolinone derivatives and their treatment of osteoporosis].
In order to obtain more effective drugs with less side effects for the treatment of osteoporosis, we designed and synthesized fourteen quinolinone derivatives. The 14 title compounds have not been reported in literature. Their structures were confirmed by elemental analysis, IR, MS and 1H-NMR. Initial pharmacological test showed that target compound TM-11 could stimulate bone formation in Wistar rat embryo in culture and showed higher activity in stimulating bone formation than ipriflavone.
Xu
M X
MX
Department of Medicinal Chemistry, West China University of Medical Sciences, Chengdu.
Duan
W H
WH
Zheng
H
H
D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001862:Bone Resorption / Q000517:prevention & control; D005333:Fetus; D010024:Osteoporosis / Q000188:drug therapy*; D015363:Quinolones / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D015363:Quinolones