title: Managing recurrent neovascularization after subfoveal surgery in presumed ocular histoplasmosis syndrome.
abstract: OBJECTIVE
  To report the authors' experience with recurrent neovascularization after subfoveal surgery in the presumed ocular histoplasmosis syndrome (POHS).
  
  
  METHODS
  One-hundred seventeen patients with POHS and subfoveal choroidal neovascularization were followed a median of 13 months after submacular surgery.
  
  
  RESULTS
  Recurrent neovascularization developed in 51 eyes (44%). The median time to recurrence was 3 months (range, 0.5-28 months). Recurrence location was extrafoveal in 16%, juxtafoveal in 18%, and subfoveal in 66%. Sixteen eyes were treated with laser photocoagulation, 17 eyes underwent repeat submacular surgery, and 18 eyes were observed. The visual outcome for patients with recurrences amenable to laser was better than that for patients who were observed or who underwent surgery.
  
  
  CONCLUSIONS
  Recurrent neovascularization after surgery is common; prompt recognition may allow laser photocoagulation.
authors.affiliation: Barnes Retina Institute, St. Louis, MO 63110, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Melberg
authors.forename: M A
authors.initials: MA
authors.lastname: Thomas
authors.forename: J D
authors.initials: JD
authors.lastname: Dickinson
authors.forename: S
authors.initials: S
authors.lastname: Valluri
mesh_terms: D002829:Choroid / Q000098:blood supply* / Q000601:surgery; D015822:Eye Infections, Parasitic / Q000150:complications*; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000601:surgery*; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans; D017075:Laser Coagulation; D008266:Macula Lutea / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000601:surgery*; D011183:Postoperative Complications / Q000601:surgery*; D012008:Recurrence; D013577:Syndrome; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects