The S100 family of EF-hand calcium-binding proteins: functions and pathology.
Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.
Schäfer
B W
BW
Department of Pediatrics, University of Zurich, Switzerland.
Heizmann
C W
CW
D002135:Calcium-Binding Proteins / Q000502:physiology*; D017433:Protein Structure, Secondary; D009418:S100 Proteins / Q000502:physiology*
D002135:Calcium-Binding Proteins; D009418:S100 Proteins