title: Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities.
abstract: New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 microM, respectively.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Omura
authors.forename: J
authors.initials: J
authors.lastname: Inokoshi
authors.forename: R
authors.initials: R
authors.lastname: Uchida
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: R
authors.initials: R
authors.lastname: Masuma
authors.forename: T
authors.initials: T
authors.lastname: Kawakubo
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Kosemura
authors.forename: S
authors.initials: S
authors.lastname: Yamamura
mesh_terms: D019883:Alkyl and Aryl Transferases; D000730:Androstadienes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D051231:Farnesyltranstransferase; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium; D014166:Transferases / Q000037:antagonists & inhibitors*
chemical_list: D000730:Androstadienes; C100395:andrastin A; C100396:andrastin B; C100397:andrastin C; D014166:Transferases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase