[Experience in the search of new prolonged-action radiation-protective agents].
The cysteamine derivative-guanidinoethanesulfanylthiosulfuric acid was demonstrated to have radioprotective properties protecting mice against X-rays and fission neutron irradiation hazard. Radioprotective efficacy shows itself for 2 hours after i.p. and p.o. administration of the preparation. It was established an opportunity of the prolonged protective action of gammaphos as a result of its cross-linking to dextran. The preparation has a radioprotective action on X-ray and neutron irradiation.
Grachev
S A
SA
Sverdlov
A G
AG
Kropachev
E N
EN
Nikanorova
N G
NG
Bondarev
G N
GN
Drobchenko
S N
SN
D004999:Amifostine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009502:Neutrons; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D003692:Delayed-Action Preparations; D003911:Dextrans; D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine
Opyt izyskaniia novykh radiozashchitnykh veshchestv prolongirovannogo deĭstviia.