Pleuroperitoneal migration of intraperitoneal phosphorus-32-chromic phosphate therapy for stage I ovarian carcinoma.
A patient with postoperative Stage I ovarian carcinoma received 15 mCi of 32P-chromic phosphate suspension in normal saline intraperitoneally as part of her therapy. The following day, a portion of the infused radiopharmaceutical and normal saline had passed transdiaphragmatically into the patient's right pleural cavity. Thoracentesis removed as much fluid as possible and this fluid contained radioactive material. In the ensuing 4 yr, the patient has not manifested any detectable pleural or pulmonary abnormalities attributable to the radioactivity. Retrospective review of 100 consecutive patients receiving 32P-chromic phosphate intraperitoneal therapy resulted in 43 patients in whom the hemithoraces could be evaluated scintigraphically. Three of the 43 patients (7%) had right pleural fluid radioactivity. This is similar to the percentages reported in patients with cirrhosis with ascites in whom hepatic hydrothorax is identified.
Wilkinson
R H
RH
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
D017608:Chromium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000532:radiotherapy*; D010529:Peritoneal Cavity; D010710:Phosphates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010994:Pleura; D010996:Pleural Effusion / Q000175:diagnosis / Q000209:etiology*; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors; D014018:Tissue Distribution
D017608:Chromium Compounds; D010710:Phosphates; D010761:Phosphorus Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid; C509369:chromic phosphate