Intraoperative radiotherapy for pancreatic carcinoma. Experimental and clinical studies.
Intraoperative radiotherapy (IORT) is an innovative treatment approach that has been tested in several Phase I-II studies and small Phase III trials in patients with resectable and unresectable pancreatic cancer. The technical approach and dose guidelines for adjacent normal tissues have been established in a series of experiments using a large animal (canine) model. This article reviews the experimental and clinical studies of IORT in cancer of the pancreas.
Kinsella
T J
TJ
Department of Human Oncology, University of Wisconsin Medical School, Madison 53792, USA.
Sindelar
W F
WF
D000818:Animals; D006801:Humans; D007430:Intraoperative Care; D010190:Pancreatic Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*