[Clinical significance of soluble interleukin-2 receptor in multiple myeloma].
Increased levels of soluble interleukin-2 receptor (sIL-2R) have been noted in the sera of patients with various diseases such as adult T cell leukemia, malignant lymphoma and autoimmune diseases. Using an enzyme-linked immunoabsorbent assay, we assessed sIL-2R levels in the sera of 16 patients with multiple myeloma (MM) and 27 normal subjects. There was a significant increase in the levels of sIL-2R in the patients with myeloma (963 +/- 523 U/ml) compared to normal subjects (213 +/- 80 U/ml). The levels of sIL-2R corresponded well with the clinical stage, M-protein, serum IL-6 and serum beta 2 microglobulin levels. Taking the evidence that the CD4/CD8 ratio decreased as the disease worsened into consideration, the increase in the serum sIL-2R levels of the patients with MM is considered to have some correlation with B and T cell activation through various cytokines including IL-6. Furthermore such evidence would support the role of sIL-2R as a disease monitor of MM.
Akimoto
Y
Y
Department of Hematology, Showa University School of Medicine, Japan.
Ishiyama
T
T
Ueno
H
H
Hino
K
K
Tomoyasu
S
S
Tsuruoka
N
N
D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008213:Lymphocyte Activation; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility; D001613:beta 2-Microglobulin / Q000032:analysis
D014408:Biomarkers, Tumor; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D001613:beta 2-Microglobulin