title: Effect of dietary restriction on cell-mediated immune responses in cattle infected with Mycobacterium bovis.
abstract: Nine M. bovis-infected cattle on a diet deficient in both protein and energy for 133 days lost approximately 17% of their original body weight. However, dietary restriction did not result in any significant reduction in skin sensitivity to PPD, in vitro production of IFN-gamma or lymphocyte blastogenesis. The number of circulating BoCD4+ cells and B cells were similar in both the malnourished and the control cattle. However, significantly lower numbers (P < 0.01) of circulating BoCD2+ cells, BoCD8+ cells, WC1+ gamma delta T cells and ACT2+ cells were found in the malnourished cattle. With the exception of inorganic phosphate, the changes in plasma biochemical parameters were unremarkable.
authors.affiliation: Faculty of Vetrinary Medicine, University College Dublin, Ballsbridge, Ireland. dohertym@irlearn.ucd.ie
authors.forename: M L
authors.initials: ML
authors.lastname: Doherty
authors.forename: M L
authors.initials: ML
authors.lastname: Monaghan
authors.forename: H F
authors.initials: HF
authors.lastname: Bassett
authors.forename: P J
authors.initials: PJ
authors.lastname: Quinn
authors.forename: W C
authors.initials: WC
authors.lastname: Davis
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D004032:Diet / Q000009:adverse effects; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D011502:Protein-Energy Malnutrition / Q000150:complications / Q000276:immunology / Q000662:veterinary; D012867:Skin / Q000276:immunology; D014374:Tuberculin Test; D014380:Tuberculosis, Bovine / Q000150:complications / Q000276:immunology*