title: Comparison of Tc-99m MIBI and Tl-201 uptake in musculoskeletal lesions.
abstract: The aim of this study was to make a comparison between the uptake of Tc-99m MIBI and Tl-201 in evaluation of musculoskeletal lesions. Fourteen cases were studied. Each study consisted of a Tl-201 study followed by a Tc-99m MIBI scan. In addition, a whole-body bone scan was performed in each patient to visualize bone metastases. Tl-201 and Tc-99m MIBI uptakes were evaluated by visual assessment and by using lesion-to-background (L/B) ratio. The authors found increased Tl-201 uptake with a mean L/B ratio of 2.81 and less Tc-99m MIBI uptake with a mean L/B ratio of 2.18 in malignant lesions. Both agents showed lower uptake with mean L/B ratios of 1.6 and 1.2 in benign lesions, but there was no statistical difference between the uptakes of either Tl-201 or Tc-99m MIBI in those with malignant and those with benign lesions. In addition, false-positive imaging was observed with both Tl-201 and Tc-99m MIBI. The results demonstrated that Tl-201 and Tc-99m MIBI accumulations in musculoskeletal lesions are not specific for malignancy.
authors.affiliation: Department of Nuclear Medicine, Istanbul University, Istanbul Medical Faculty, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Adalet
authors.forename: H
authors.initials: H
authors.lastname: Ozger
authors.forename: S
authors.initials: S
authors.lastname: Cantez
mesh_terms: D000293:Adolescent; D000328:Adult; D001847:Bone Diseases / Q000000981:diagnostic imaging; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000000981:diagnostic imaging*; D009135:Muscular Diseases / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi