title: Comparison of antegrade with antegrade/retrograde cold blood cardioplegia for myocardial revascularization.
abstract: There has been increasing interest in the use of retrograde coronary sinus perfusion for delivery of cardioplegic solution during myocardial revascularization. Despite evidence of improved cardiac protection, it is unclear if a combined antegrade/retrograde approach to myocardial preservation offers significant clinical benefits. One hundred twenty patients undergoing elective 1st-time coronary bypass surgery for 3-or-more-vessel disease received aortic root, antegrade cold blood cardioplegia (Group I, n=52) or combined antegrade/retrograde cardioplegia via coronary sinus cannulation (Group II, n=68). All preoperative variables were similar, including age, severity of coronary artery disease, functional status, and ejection fraction. Intraoperative and postoperative variables, including the degree of hypothermia, temperature of infusion solution, number of bypass grafts, defibrillation attempts and spontaneous return to sinus rhythm, the use of intraaortic balloon pump counterpulsation, and inotropic support during weaning from cardiopulmonary bypass, were not statistically different. Cardioplegia infusion time was longer in Group II than in Group I (2.5 +/- 0.8 vs 1.7 +/- 0.7 min, p < 0.05). The postoperative cardia output, electrocardiographic and cardiac enzyme evidence of ischemia, the need for temporary pacing, and 30-day morbidity were similar for both groups. The data indicate that in this non-risk-stratified group of patients, the route of cardioplegia administration is not a determinant of clinical outcome.
authors.affiliation: Department of Surgery, Cooper Hospital/University Medical Center, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden 08103, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Cernaianu
authors.forename: D R
authors.initials: DR
authors.lastname: Flum
authors.forename: M
authors.initials: M
authors.lastname: Maurer
authors.forename: J H
authors.initials: JH
authors.lastname: Cilley
authors.forename: M A
authors.initials: MA
authors.lastname: Grosso
authors.forename: L
authors.initials: L
authors.lastname: Browstein
authors.forename: A J
authors.initials: AJ
authors.lastname: DelRossi
mesh_terms: D001769:Blood; D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D011183:Postoperative Complications / Q000453:epidemiology; D000077331:Ringer's Solution; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002314:Cardioplegic Solutions; D007552:Isotonic Solutions; D000077331:Ringer's Solution