A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.
Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction. We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.
Fernandez-Sesma
A
A
Microbiology Department, Mount Sinai Medical Center, New York, New York 10029, USA.
Schulman
J L
JL
Moran
T M
TM
D000595:Amino Acid Sequence; D000818:Animals; D018033:Antibodies, Bispecific / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D002460:Cell Line; D004285:Dogs; D004768:Enterotoxins / Q000494:pharmacology; D006801:Humans; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014763:Viral Matrix Proteins / Q000276:immunology*; D014779:Virus Replication / Q000276:immunology; D000086082:Viroporin Proteins
D018033:Antibodies, Bispecific; D000914:Antibodies, Viral; D004768:Enterotoxins; D014763:Viral Matrix Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C031818:enterotoxin B, staphylococcal