Comparative teratological studies on TCDD, endrin and lindane in C57BL/6J and DBA/2J mice.
The teratogenic effects of endrin and lindane have been determined and compared to those induced by TCDD in the fetuses of C57BL/6J and DBA/2J mice after the administration of single oral doses to pregnant mice on day 12 of gestation. TCDD produced dose-dependent decreases in fetal weight, fetal thymic weight and placental weight, and dose-dependent increases in fetolethality, cleft palate formation and hydronephrosis at doses of 10-30 and 30-60 micrograms/kg body weight in C57BL/6J and DBA/2J mice, respectively. No maternal death was observed at the given doses in both strains of mice. Endrin (4.5 and 6 mg/kg body weight) and lindane (30 and 45 mg/kg body weight) produced significant decreases in fetal weight and placental weight in C57BL/6J and DBA/2J mice, and dose-dependent decreases in fetal thymic weight in C57BL/6J mice but not DBA/2J mice. Endrin and lindane caused 0-25 and 14-25% maternal deaths, respectively, at the above mentioned doses. Neither cleft plate nor hydronephrosis were induced by endrin or lindane in the two strains of mice. The results support the hypothesis that TCDD-induced cleft plate and hydronephrosis involve mechanisms that are Ah (aryl hydrocarbon) receptor mediated. However, other fetotoxic effects induced by TCDD, and the fetotoxic effects induced by endrin and lindane may involve additional unknown mechanisms that are not related to the Ah-receptor.
Hassoun
E A
EA
School of Pharmacy and Allied Health Professions, Creighton University, Omaha, NE 68178, USA.
Stohs
S J
SJ
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004732:Endrin / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D006869:Hydronephrosis / Q000139:chemically induced; D007306:Insecticides / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy
D007306:Insecticides; D000072317:Polychlorinated Dibenzodioxins; D001556:Hexachlorocyclohexane; D004732:Endrin