title: Microcolposcopic topographic endocervical assessment before excisional treatment of cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To evaluate whether microcolposcopic topographic endocervical assessment reduces the failures of excisional treatment of cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  Three hundred fifty patients with colposcopic and histopathologic findings of endocervical CIN were recruited for excisional treatment. Three hundred forty-eight of these were randomized to have or not have microcolposcopy before excisional treatment. Measurement of endocervical lesion was the only aim of microcolposcopic evaluation. When an endocervical extension was available, the cone biopsy was cut according to microcolposcopic measurement. Excision status was evaluated and related to presurgical management on operative specimens. After excision, patients were followed-up for at least 5 years after treatment. Three hundred thirty (171 and 159 with and without preoperative microcolposcopy, respectively) patients completed the study. Disease persistences were defined by cytologic, colposcopic, and histologic results. Microcolposcopic value was defined as completeness of excision and/or lack of persistent disease. RESULTS. On surgical specimens, involved margins were detected in 19 (5.4%) cases. Presurgical microcolposcopy was performed in only one of these cases. The difference of incomplete excision between cases with or without microcolposcopy was statistically significant (P < .001). In patients who were followed-up, persistent disease was detected in one (0.6%) woman in the microcolposcopy group and in 16 (10%) women in the control group. Comparison between the two groups showed a significantly lower risk of persistent disease when presurgical microcolposcopy was performed (P < .001).
  
  
  CONCLUSIONS
  By measuring endocervical extension of the lesion, preoperative microcolposcopy allows individualized cones, thus improving the prognosis after excisional treatment of CIN.
authors.affiliation: II Department of Obstetrics and Gynecology, Bologna University School of Medicine, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Guerra
authors.forename: G
authors.initials: G
authors.lastname: Guida
authors.forename: P
authors.initials: P
authors.lastname: Falco
authors.forename: S
authors.initials: S
authors.lastname: Gabrielli
authors.forename: G N
authors.initials: GN
authors.lastname: Martinelli
authors.forename: L
authors.initials: L
authors.lastname: Bovicelli
mesh_terms: D000293:Adolescent; D000328:Adult; D003127:Colposcopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011300:Preoperative Care; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000601:surgery