title: [Acquired toxoplasmosis of ocular or neurologic site: 49 cases].
abstract: OBJECTIVE
  Over a period of 13 years (1982-1995), 49 cases of acquired toxoplasmosis complicated with ocular and/or neurologic or meningeal involvement were observed in our toxoplasmosis laboratory. This series includes 43 cases of isolated ocular lesions, 3 cases of meningoencephalitis (associated with retinochoroiditis in 1 case), 1 case of meningitis with uveitis, 1 case of polyradiculoneuritis and 1 case of facial nerve palsy.
  
  
  METHODS
  The patients were aged 1 to 62 years. None had either spontaneous or iatrogenic immunodeficiency. There were two steps in the diagnosis. First congenital infection was eliminated on one or several of the following criteria: any possibility of maternal infection during pregnancy ruled out in 26 cases, evidence of recent acquired infection (i.e. clinical and/or serological evidence of recent acquired toxoplasmosis in 17 cases, retinochoroiditis in non-twin siblings in 3 cases). The second step was to confirm the diagnosis of toxoplasma infection. Apart from serological evidence of recent infection, confirmation included specific local antibody synthesis in the aqueous humor of the eye and/or in cerebro-spinal fluid or ocular lesions characteristic of toxoplasmosis and absence of other etiology.
  
  
  RESULTS
  Ocular lesions were unilateral in 43 cases among 45. A mean follow-up of 37.9 months revealed relapses in 14 among 36 patients (39%). As routine serological examination for toxoplasmosis is compulsory in France since 1978, it was possible to document retrospectively the immune status of the mothers of many of the patients of the present series during pregnancy and to rule out congenital toxoplasmosis in a number of cases. This might explain the discrepancy between the relatively large number of cases in the present series and the fact that complicated acquired toxoplasmosis has been considered hitherto as relatively rare in immunocompetent patients.
  
  
  CONCLUSIONS
  Based on the epidemiology of ocular toxoplasmosis and the data obtained here, it is suggested that the acquired pattern of ocular toxoplasmosis might be more frequent than estimated up to now.
authors.affiliation: Laboratoire de la Toxoplasmose, Institut de Puériculture, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Couvreur
authors.forename: P
authors.initials: P
authors.lastname: Thulliez
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D008590:Meningoencephalitis / Q000469:parasitology; D008875:Middle Aged; D012008:Recurrence; D016781:Toxoplasmosis, Cerebral / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000150:complications / Q000453:epidemiology* / Q000276:immunology
vernacular_title: Toxoplasmose acquise à localisation oculaire ou neurologique: 49 cas.