title: Lung volume reduction in patients with severe diffuse emphysema. A retrospective study.
abstract: BACKGROUND
  For most authors, surgery of emphysema is restricted to resection of large bullae, whereas resection of small bullae or lung volume reduction is generally considered to have poor results.
  
  
  OBJECTIVE
  To report our experience of lung volume reduction in patients with severe emphysema without large bullae.
  
  
  METHODS
  Thirteen patients were operated on from 1982 to 1992. Before surgery, they all had severe diffuse emphysema with a dyspnea grade 4 or 5 and mean FEV1 values of 18 +/- 5% of predicted. Seven patients had a PaCO2 greater than 42 mm Hg. On radiologic evaluation, they had either small bullae or, most often, areas of destroyed lung.
  
  
  METHODS
  The surgical procedure was unilateral in 11 patients and bilateral in 2.
  
  
  RESULTS
  Postoperative assessment included dyspnea grading, FEV1 measurements, and blood gas analysis followed at 6- to 12-month intervals. There was no perioperative mortality and the morbidity was limited. At 6, 12, 18, 24, and 36 months postoperatively, a symptomatic improvement was observed in 92%, 85%, 54%, 31%, and 31% of the patients, respectively, with FEV1 increasing by at least 20% in 92%, 46%, 46%, 31%, and 24% of the patients, respectively.
  
  
  CONCLUSIONS
  Our data show that lung volume reduction may result in symptomatic and spirometric improvement in patients with severe emphysema without large bullae.
authors.affiliation: Service de Pneumologie et Réanimation Respiratoire, Hôpital Beaujon, Clichy, France.
authors.forename: C
authors.initials: C
authors.lastname: Roué
authors.forename: H
authors.initials: H
authors.lastname: Mal
authors.forename: C
authors.initials: C
authors.lastname: Sleiman
authors.forename: M
authors.initials: M
authors.lastname: Fournier
authors.forename: J P
authors.initials: JP
authors.lastname: Duchatelle
authors.forename: P
authors.initials: P
authors.lastname: Baldeyrou
authors.forename: R
authors.initials: R
authors.lastname: Pariente
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D011659:Pulmonary Gas Exchange; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014109:Total Lung Capacity