title: Structure-function relationships in the Ca(2+)-ATPase of sarcoplasmic reticulum: facts, speculations and questions for the future.
abstract: Structural data on the Ca(2+)-ATPase of sarcoplasmic reticulum are integrated with kinetic data on Ca2+ transport. The emphasis is upon ATPase-ATPase interactions, the requirement for phospholipids, and the mechanism of Ca2+ translocation. The possible role of cytoplasmic [Ca2+] in the regulation of the synthesis of Ca(2+)-ATPase is discussed.
authors.affiliation: Department of Biochemistry and Molecular Biology, State University of New York, Syracuse 13210, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Martonosi
mesh_terms: D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology; D000252:Calcium-Transporting ATPases / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D010743:Phospholipids / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D015220:Calcium Channels; D010743:Phospholipids; D000252:Calcium-Transporting ATPases; D002118:Calcium