title: [What becomes of free septum cartilage transplants? Experimental studies of orthotopic cartilage transplantation].
abstract: BACKGROUND. Orthotopic septal cartilage transplants are grafted in numerous rhinosurgical operations. To ensure long-lasting success of surgery, preservation of the vitality of the grafted cartilage is imperative. Although many studies have been conducted on heterotopic cartilage transplants, no studies have been published on a follow-up of the course of orthotopic grafts. METHODS. We performed submucous septal resection in 33 rabbits and then regrafted the cartilage between the laminae of the mucous membrane. Microangiography was performed one, two, six and twelve weeks later and the cartilage was then examined histologically. Cartilage biopsies were performed on humans and compared with the experimental results. RESULTS. Integration of the cartilage presented a characteristic pattern: In the rabbit, the grafted cartilage had healed completely and had been stably integrated in three months' time. Reintegration with the orthotopic cartilage occurred by means of appositional reorganisation of cartilage originating from the inner perichondrium. Microangiography revealed that reintegration took place the faster, the shorter the distance between the cartilage cells and the vessels. We confirmed these experimental results also clinically by means of the cartilage biopsies in man.
authors.affiliation: Klinik für Plastische Chirurgie, Marienhospital, Stuttgart.
authors.forename: W
authors.initials: W
authors.lastname: Gubisch
authors.forename: K
authors.initials: K
authors.lastname: Donath
mesh_terms: D000792:Angiography; D000818:Animals; D001706:Biopsy; D002356:Cartilage / Q000098:blood supply / Q000473:pathology / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D008297:Male; D009300:Nasal Septum / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D012225:Rhinoplasty / Q000379:methods*
vernacular_title: Was wird aus dem freiverpflanzten Septumknorpel? Experimentelle Untersuchungen zur orthotopen Knorpeltransplantation.