title: Prospective, controlled study of the outcome of human immunodeficiency virus-1 antibody-positive children admitted to an intensive care unit.
abstract: OBJECTIVE
  Intensive care resources are both scarce and costly in South Africa. We set out to ascertain whether human immunodeficiency virus (HIV) status affects the spectrum of disease and the prognosis in children treated in pediatric intensive care units (ICUs).
  
  
  METHODS
  A prospective, case-controlled study.
  
  
  METHODS
  The pediatric ICU at Kind Edward VIII Hospital, Durban, South Africa.
  
  
  METHODS
  HIV-positive cases were classified as "acquired immunodeficiency syndrome," "symptomatic HIV," and "HIV-unrelated diseases." Controls were matched for age, race, gender, severity of disease, and admitting diagnosis.
  
  
  RESULTS
  THe clinician was blinded to the serostatus of patients. Informed consent and Ethics Committee approval were obtained for HIV testing and the study. Outcome measures were the duration of intermittent positive-pressure ventilation and ICU stay, maximum ventilatory requirements, infectious complications, and mortality. There were 11 cases of acquired immune deficiency (AIDS), 24 cases of symptomatic HIV, and 13 cases of HIV-unrelated diseases. Mortality rates for the three groups were as follows: 100% in patients with AIDS compared with 55% in their controls (p<.01); 38% in patients with symptomatic HIV and 46% in controls. Cytomegalovirus and Pneumocystis carinii infections were significantly increased (p<.01, p<.002, respectively) in patients with AIDS as compared with controls. Outcome measures were similar in those patients with symptomatic HIV and those patients with HIV-unrelated diseases, as compared with their respective controls.
  
  
  CONCLUSIONS
  Outcome in children with AIDS admitted to the pediatric ICU was significantly worse than the outcome in HIV-uninfected children. However, the number of AIDS patients studied was small. HIV antibody-positive children without AIDS do as well as uninfected controls. Ethics committees in resource-constrained countries may be assisted by such data when making difficult decisions on the admissions of HIV-infected patients to pediatric ICU facilities.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Natal, Durban, South Africa.
authors.forename: P M
authors.initials: PM
authors.lastname: Jeena
authors.forename: H M
authors.initials: HM
authors.lastname: Coovadia
authors.forename: S
authors.initials: S
authors.lastname: Bhagwanjee
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality / Q000628:therapy*; D016022:Case-Control Studies; D004992:Ethics, Medical; D005260:Female; D015658:HIV Infections / Q000401:mortality / Q000628:therapy*; D015497:HIV-1; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D007385:Intermittent Positive-Pressure Ventilation; D007902:Length of Stay; D008297:Male; D017063:Outcome Assessment, Health Care; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D013019:South Africa