Serum levels of circulating intercellular adhesion molecule 1 in hepatocellular carcinoma.
OBJECTIVE
This is a comparative study of the relationship between.


METHODS
Serum levels of circulating intercellular adhesion molecule-1 (cICAM-1) were measured by ELISA assay in four patients with chronic hepatitis (CH), 16 with liver cirrhosis (LC), 38 with hepatocellular carcinoma (HCC), and in nine healthy controls.


RESULTS
No significant difference in cICAM-1 levels was observed between LC and HCC. The cICAM-1 level in HCC did not correlate with tumor markers but correlated well with tumor size. cICAM-1 level in HCC Stage III + IV was significantly higher than that of Stage I, and was higher in HCC with liver metastasis as opposed to HCC without metastasis. Furthermore, the cICAM-1 level of HCC decreased significantly after hepatectomy.


CONCLUSIONS
These findings showed a close relationship between cICAM-1 and the progress of intrahepatic metastasis of HCC, indicating a possibility for using cICAM-1 as a prognostic marker.
Hamazaki
K
K
First Department of Surgery, Okayama University Medical School.
Gochi
A
A
Shimamura
H
H
Kaihara
A
A
Maruo
Y
Y
Doi
Y
Y
Orita
K
K
Lygidakis
N J
NJ
D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006498:Hepatectomy; D006505:Hepatitis / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood*; D009362:Neoplasm Metastasis; D011379:Prognosis
D014408:Biomarkers, Tumor; D018799:Intercellular Adhesion Molecule-1