title: Systemic lupus erythematosus diagnosed during interferon alfa therapy.
abstract: We describe a patient who had clinical manifestations of several autoimmune disorders: Sjögren's syndrome, benign hypergammaglobulinemic purpura of Waldenström, and systemic lupus erythematosus (SLE). The SLE was diagnosed during therapy with interferon alfa. Testing for anti-Ro and anti-La antibodies was negative until the serum was diluted to eliminate a possible prozone phenomenon of antibody excess.
authors.affiliation: Department of Dermatology, University of Texas Medical School, Houston, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Morris
authors.forename: N A
authors.initials: NA
authors.lastname: Lemak
authors.forename: F C
authors.initials: FC
authors.lastname: Arnett
authors.forename: R E
authors.initials: RE
authors.lastname: Jordon
authors.forename: M
authors.initials: M
authors.lastname: Duvic
mesh_terms: D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D016898:Interferon-alpha / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011693:Purpura / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000188:drug therapy / Q000209:etiology*; D008258:Waldenstrom Macroglobulinemia / Q000209:etiology*
chemical_list: D016898:Interferon-alpha