Subchronic toxicity study of domoic acid in the rat.
Male and female Sprague-Dawley rats were dosed by gavage for 64 days with 0, 0.1 or 5 mg/kg/day domoic acid. Treated animals showed no clinical abnormalities. Terminal values in haematology and clinical chemistry did not reveal differences between treated and control groups. Findings in histopathology and immunohistochemistry were unremarkable. The 24-hr urinary excretion rate for domoic acid determined at three time points was approximately 1.8% of the dose and remained unchanged during the study.
Truelove
J
J
Toxicology Research Division, Health Protection Branch, Sir F.G. Banting Research Centre, Tunney's Pasture, Ottawa, Canada.
Mueller
R
R
Pulido
O
O
Iverson
F
F
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006403:Hematologic Tests; D007608:Kainic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity / Q000652:urine; D008297:Male; D008387:Marine Toxins / Q000008:administration & dosage / Q000633:toxicity* / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley
D008387:Marine Toxins; D003402:Creatine Kinase; C012301:domoic acid; D007608:Kainic Acid