[New antibacterial vaccinal strategies].
The prevalence of bacterial diseases and bacterial resistance is currently increasing, emphasizing the need for alternative vaccines. The body of knowledge on molecular determinants of bacterial virulence has tremendously increased during the recent years, and new molecular targets are available for immunization. Intramuscular injection of plasmid DNA containing bacterial genes with a suitable appropriate promotor is followed by transfection of host cells which will produce bacterial proteins, and elicit humoral and cytotoxic lymphocyte-mediated responses. Mucosal vaccines induce local immune response, both by type 1 and type 2 dependent pathways. Living bacterial vectors can provide conditional delivery of foreign antigens in selected host sites. A series of new substances allows us to steer the immune response in a way that optimizes immune protection. All this impressive progress will undoubtedly lead to the development of novel vaccines enabling us to ensure improved protection against bacterial diseases.
Kok
M
M
Pechère
J C
JC
D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000008:administration & dosage; D004269:DNA, Bacterial / Q000276:immunology; D006801:Humans; D009092:Mucous Membrane / Q000276:immunology; D014611:Vaccination / Q000379:methods*; D014774:Virulence
D001428:Bacterial Vaccines; D004269:DNA, Bacterial
Nouvelles stratégies vaccinales antibactériennes.