title: [Prognostic significance of the S-phase and MIB1 (Ki-67) proliferation parameters in node-negative breast carcinoma].
abstract: OBJECTIVE
  In 90 patients with primary node-negative breast carcinomas we compared the prognostic impact of total S-phase fraction (SPF) and MIB1 proliferation rate (MIB1-PR) after a median follow-up of 34 months (9-72 months).
  
  
  METHODS
  SPF was determined flow cytometrically and MIB1 (Ki-67) immunohistochemically in parallel-cut, paraffin-embedded tissue sections.
  
  
  RESULTS
  SPF was significantly correlated to tumor size and steroid hormone receptor status, MIB1-PR to grading. In univariate analysis both SPF and MIB1-PR were significant prognostic factors for disease-free survival. In multivariate analysis however, S-phase fraction was the only significant prognostic factor when compared to MIB1-PR, tumor size, steroid hormone receptor status, menopausal status, grading, lymph vessel invasion, and tumor necrosis.
  
  
  CONCLUSIONS
  In our study SPF was of higher prognostic strength and may therefore be better suited for clinical application than MIB1-PR in node-negative breast cancer.
authors.affiliation: Frauenklinik, Technischen Universität München.
authors.forename: N
authors.initials: N
authors.lastname: Harbeck
authors.forename: P
authors.initials: P
authors.lastname: Dettmar
authors.forename: Ch
authors.initials: Ch
authors.lastname: Thomssen
authors.forename: L
authors.initials: L
authors.lastname: Pache
authors.forename: P
authors.initials: P
authors.lastname: Ziffer
authors.forename: K
authors.initials: K
authors.lastname: Fizi
authors.forename: F
authors.initials: F
authors.lastname: Jänicke
authors.forename: W
authors.initials: W
authors.lastname: Nathrath
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: H
authors.initials: H
authors.lastname: Graeff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000502:physiology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016196:S Phase / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins
vernacular_title: Prognostische Bedeutung der Proliferationsparameter S-Phase und MIB1 (Ki-67) beim nodal-negativen Mammakarzinom.