title: [Overexpression of p53 protein in ovarian carcinomas: correlation with histopathologic data and clinical course].
abstract: OBJECTIVE
  The accumulation of p53 protein was analysed immunohistochemically in ovarian cancer and correlated with clinical data to further clarify the role of p53 mutations for prognosis in these patients.
  
  
  METHODS
  Tumor tissues from 126 epithelial ovarian carcinomas were analysed immunohistochemically on paraffin embedded tissue and in 21 cases on frozen tissue with monoclonal antibodies PAb 1801, PAb 421 and PAb 240.
  
  
  RESULTS
  Nuclear p53 staining was found in 31 ovarian carcinomas (25%) and correlated with advanced stage of the disease (p = 0,038) and poor differentiation (P = 0,032) of the tumor. Disease-free and overall-survival time were slightly, but not significantly shortened for patients with p53 positive tumors.
  
  
  CONCLUSIONS
  Immunohistochemically detectable p53 protein expression in ovarian carcinoma is associated with poor differentiation, advanced stage of the disease and a tendency for shortened disease-free and overall survival.
authors.affiliation: Frauenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakultät, Humboldt-Universität zu Berlin.
authors.forename: A
authors.initials: A
authors.lastname: Reles
authors.forename: M F
authors.initials: MF
authors.lastname: Press
authors.forename: I
authors.initials: I
authors.lastname: Schönborn
authors.forename: W
authors.initials: W
authors.lastname: Lichtenegger
authors.forename: T
authors.initials: T
authors.lastname: Strohmeyer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53
vernacular_title: p53 Proteinüberexpression in Ovarialkarzinomen: Korrelation mit histopathologischen Daten und klinischem Verlauf.