title: Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes.
abstract: Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.
authors.affiliation: Faculty of Engineering, Fukuyama University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Haraguchi
authors.forename: I
authors.initials: I
authors.lastname: Ohmi
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Mizutani
authors.forename: O
authors.initials: O
authors.lastname: Tanaka
authors.forename: W H
authors.initials: WH
authors.lastname: Chou
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D005985:Glyceraldehyde / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D007908:Lens, Crystalline / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology; D009097:Multienzyme Complexes / Q000032:analysis; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis; D009249:NADP / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000737:chemistry*; D011794:Quercetin / Q000494:pharmacology; D013552:Swine
chemical_list: D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D005419:Flavonoids; D044948:Flavonols; D009097:Multienzyme Complexes; C099069:astilbin; D005985:Glyceraldehyde; D009249:NADP; D011794:Quercetin; D000449:Aldehyde Reductase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases