Expression of thrombospondin-1 in cancer: a role in tumor progression.
Thrombospondin-1 (TSP-1), a trimeric high molecular weight glycoprotein, is one of the major secreted proteins of human platelets and an extracellular matrix component of a variety of cells including vascular endothelial cells and tumor cells. TSP-1 has been shown to be highly expressed in human malignant tissues and present in higher than normal levels in the plasma of cancer patients. TSP-1 has also been shown to promote hematogenous tumor spread, tumor cell adhesion and invasion, and angiogenesis. Overall these studies provide compelling evidence for the conclusion that TSP-1 plays an important role in tumor progression.
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Department of Surgery, Medical College of Pennsylvania and Hahnemann University, Phildelphia 19129, USA.
Tuszynski
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D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D018955:CD36 Antigens / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D019699:Thrombospondins; D014407:Tumor Cells, Cultured
D001798:Blood Proteins; D018955:CD36 Antigens; D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D008562:Membrane Glycoproteins; D019699:Thrombospondins