title: The clinical outcome of preterm premature rupture of membranes in twin versus singleton pregnancies.
abstract: The purpose of this study was to determine the clinical outcome of preterm premature rupture of the membranes (PPROM) in twin versus singleton pregnancies at less than or equal to 36 weeks' gestation. A retrospective cohort study was conducted in 116 twin pregnancies with PPROM at less than or equal to 36 weeks' gestational age and 116 matched singleton pregnancies. The two groups were analyzed for differences in maternal demographics and perinatal and neonatal outcome. Perinatal and neonatal outcomes were similar in the two groups. The median latency period, however, was significantly decreased in the twin group (11.4 hours, Inter Quartile Range: 6.3-26.4) versus the singleton group (19.5 hours, Inter Quartile Range: 10.2-49.3, p < 0.05). The latency period in each group was notably longer when PPROM occurred at less than 30 weeks' gestation, but was still shorter in the twin pregnancies (27.6 hours, Inter Quartile Range: 20-307 versus 75.1 hours, Inter Quartile Range: 15-189, p < 0.05). Twin pregnancies with PPROM at less than or equal to 36 weeks' gestational age have a decreased latency period when compared to matched singletons. The perinatal and neonatal outcomes, however, are similar.
authors.affiliation: Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10029, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Bianco
authors.forename: J
authors.initials: J
authors.lastname: Stone
authors.forename: R
authors.initials: R
authors.lastname: Lapinski
authors.forename: C
authors.initials: C
authors.lastname: Lockwood
authors.forename: L
authors.initials: L
authors.lastname: Lynch
authors.forename: R L
authors.initials: RL
authors.lastname: Berkowitz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D012189:Retrospective Studies; D013997:Time Factors; D014427:Twins