title: Treatments for second malignancies after gastrectomy for stomach cancer.
abstract: OBJECTIVE
  Metachronous primary cancers after stomach cancer were reported as a cause of late death. It is necessary to treat these second malignancies to improve the result of surgical treatment for gastric cancer.
  
  
  METHODS
  Among 3,570 patients who underwent gastrectomy during 1961-1986, 160 second primary malignancies were observed as of December of 1991. Liver (27 patients) and colorectal (18 patients) cancers were the largest in number.
  
  
  RESULTS
  By the end of 1992, for 32 liver tumors small resection, transcatheter arterial embolization and percutaneous ethanol injection were carried out and 3-year survival of resected cases (6 patients; 80.0%) was better than that of nonresected cases (26; 3.8%) (p < 0.05). In 19 colorectal cancers, surgical resection (13/19) and combined locoregional chemotherapy (2/19) were actively performed, and 5-year survival of resected cases (13; 55.4%) was better than that of nonresected cases (6; 0%) (p < 0.05).
  
  
  CONCLUSIONS
  With an intensive long-term follow-up after gastrectomy for cancer, early diagnosis and effective therapy for second primary malignancies is improved.
authors.affiliation: Department of Surgery, Center for Adult Diseases, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Hiratsuka
authors.forename: T
authors.initials: T
authors.lastname: Iwanaga
authors.forename: S
authors.initials: S
authors.lastname: Imaoka
authors.forename: T
authors.initials: T
authors.lastname: Kabuto
authors.forename: O
authors.initials: O
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Kameyama
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
authors.forename: S
authors.initials: S
authors.lastname: Nakamori
mesh_terms: D015179:Colorectal Neoplasms / Q000628:therapy; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000628:therapy*; D013274:Stomach Neoplasms / Q000601:surgery*; D015996:Survival Rate
chemical_list: D000431:Ethanol