Experimental myocarditis in the guinea-pig.
In guinea-pigs, myocarditis was induced under experimental conditions by immunizing the animals with rabbit skeletal muscle myosin-beta. The salient histopathological features were foci of perivascular lymphonononuclear aggregates, necrosis, and degeneration of myocardial cells. Antimyosin-beta antibodies in the immune complexes were demonstrated in the sera of the guinea-pigs. An immune-complex-mediated tissue-injury is proposed in the pathogenesis of myocarditis.
Radhakrishnan
V V
VV
Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India.
D000818:Animals; D000906:Antibodies / Q000097:blood; D000936:Antigen-Antibody Complex / Q000097:blood; D004195:Disease Models, Animal; D006168:Guinea Pigs; D009205:Myocarditis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D009218:Myosins / Q000008:administration & dosage* / Q000276:immunology; D009336:Necrosis; D011817:Rabbits
D000906:Antibodies; D000936:Antigen-Antibody Complex; D009218:Myosins