New prenylflavones from the leaves of Epimedium saggitatum.
Five new prenylflavones, yinyanghuo A (1), yinyanghuo B (2), yinyanghuo C (3), yinyanghuo D (4), and yinyanghuo E (5), along with six known flavonoids, chrysoeriol, quercetin, apigenin, apigenin 7,4'-dimethyl ether, kaempferol, and luteolin, were isolated from the leaves of Epimedium sagittatum. Their structures were determined from spectral analysis. Compounds 1 and 2 showed significant antiplatelet induced by arachidonic acid.
Chen
C C
CC
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Republic of China.
Huang
Y L
YL
Sun
C M
CM
Shen
C C
CC
D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009391:Nephelometry and Turbidimetry; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan
D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid