[The combination assay of tumor markers by multivariate analysis for improvements of the diagnostic precision in malignancies].
Since 1987, we have been trying to develop a computer-aided multivariate pattern analysis system (CAMPAS) with the focus on ovarian tumors using a discriminant analysis, which is one of multivariate analysis, to raise specificity while retaining sensitivity of combination assay as high as possible. We applied this CAMPAS which was developed in collaboration with SRL (Tokyo, Japan) under the guidance of Prof. Em. Terashima, Y.(The Jikei University School of Medicine, Tokyo, Japan). CAMPAS OV-2, which is the newest one, based on 2 discriminant formulas with 6 tumor markers, ie, cancer antigen 125 (CA125), immunosuppressive acidic protein (IAP), tissue polypeptide antigen (TPA), alkaline phosphatase (ALP), albumin and iron (Fe), was developed and practised prospectively as a pretherapeutic serological diagnostic means to distinguish epithelial ovarian carcinomas from benign ones tumors. The sensitivity and specificity reached 87.1% and 82.9%, respectively in CAMPAS OV-2.
Okajima
Y
Y
Chiba Social Insurance Hospital.
Fukasawa
I
I
Inaba
N
N
D014408:Biomarkers, Tumor / Q000032:analysis*; D003658:Decision Making, Computer-Assisted; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D009369:Neoplasms / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000175:diagnosis; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor