title: [Hypersomnia in multiple sclerosis].
abstract: A 13-year-old girl presented with hyersomnia and incontinence of urine. The clinical course was complicated by strabism, muscle weakness and coordination and balance disturbances. VEP recording were pathologic. Myelin basic protein in the cerebrospinal fluid was elevated. Nuclear resonance imaging of the brain revealed multiple areas of demyelination. These findings supported the diagnosis of multiple sclerosis. There was a marked disturbance of the sleep-waking-pattern during the acute phase of the illness. The hypnogram resembled the pattern of polysymptomatic narcolepsy. Regression of symptoms was noted with dexamethasone therapy.
authors.affiliation: Vestische Kinderklinik Datteln, Universität Witten-Herdecke.
authors.forename: B
authors.initials: B
authors.lastname: Schlüter
authors.forename: G
authors.initials: G
authors.lastname: Aguigah
authors.forename: W
authors.initials: W
authors.lastname: Andler
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology*; D003937:Diagnosis, Differential; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D009290:Narcolepsy / Q000175:diagnosis / Q000503:physiopathology; D009460:Neurologic Examination; D017286:Polysomnography; D012894:Sleep Stages / Q000502:physiology*
chemical_list: D004676:Myelin Basic Protein
vernacular_title: Hypersomnie bei Multipler Sklerose.