title: Strategy for breast conserving treatment--analysis of recurrence and prognosis after breast cosnserving treatment.
abstract: Two hundred and four patients with small breast cancer (T < or = 3.0 cm. N0 or N1a) were given breast conserving treatment (radiation group: 101, non-radiation group: 103) during the period from Feb. 1988 to Jan. 1995. Survival analysis of breast conserving treatment radiation group versus non-radiation group revealed the following: 1) Breast conserving treatment had a good prognosis, and a 5-year overall survival rate of 96.2%. 2) There was no significant difference of 5-year overall, disease-free and ipsilateral breast disease-free survival rate between the radiation group and non-radiation group. 3) Surgical margin involvement was the most significant risk factor in local recurrence after breast conserving treatment, and non-radiation was a possible risk factor. 4) Local recurrence was a significant risk factor for distant metastases after breast conserving treatment the same as node positive. These results suggested as follows: 1) Lumpectomy with a clear margin and radiation is the best choice for small breast cancer (T < or = 3.0 cm, N0 or N1a). 2) Adjuvant therapy after surgical treatment is necessary for local recurrence.
authors.affiliation: Dept. of Surgery, Osaka National Hospital, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Shin
authors.forename: Y
authors.initials: Y
authors.lastname: Takatsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Mishima
authors.forename: T
authors.initials: T
authors.lastname: Tono
authors.forename: T
authors.initials: T
authors.lastname: Yagyu
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Kikkawa
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: A
authors.initials: A
authors.lastname: Kurata
authors.forename: M
authors.initials: M
authors.lastname: Otani
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate