title: [Development and study of the properties of immunoglobulin against Ebola fever].
abstract: Immunoglobulin to Ebola fever has been for the first time prepared from hyperimmune equine blood sera by alcohol fractionation after Cohn. Preclinical study of the physicochemical and immunobiological properties of immunoglobulin showed that it protects up to 100% Papio hamadryas infected intramuscularly at doses of 110 to 29 LD50 Ebola virus. Scheme for the use of Ebola immunoglobulin has been experimentally validated.
authors.forename: I V
authors.initials: IV
authors.lastname: Borisevich
authors.forename: V V
authors.initials: VV
authors.lastname: Mikhaĭlov
authors.forename: V P
authors.initials: VP
authors.lastname: Krasnianskiĭ
authors.forename: V N
authors.initials: VN
authors.lastname: Gradoboev
authors.forename: E V
authors.initials: EV
authors.lastname: Lebedinskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Potryvaeva
authors.forename: G D
authors.initials: GD
authors.lastname: Timan'kova
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000628:therapy*; D007106:Immune Sera; D007136:Immunoglobulins / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D010215:Papio; D011817:Rabbits
chemical_list: D000914:Antibodies, Viral; D007106:Immune Sera; D007136:Immunoglobulins
vernacular_title: Razrabotka i izuchenie svoĭstv immunoglobulina protiv likhoradki Ebola.