Relaxation of imprinting in carcinogenesis.
The study of genes at the heat of tumorigenesis has helped unveil an elaborate biochemical circuitry that governs the proliferation and differentiation of cells. Genomic imprinting is rapidly being recognized as a fundamental process in tumor biology. Aberrant relaxation of imprinted genes have been detected in a wide variety of cancers, of both embryonal and nonembryonal origin. However, despite a vast array of experimental observation, both the purpose and pathogenic mechanism of relaxation of imprinting remain an enigma. Hypotheses are examined in this regard along with speculation for future research.
Glassman
M L
ML
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel.
de Groot
N
N
Hochberg
A
A
D002869:Chromosome Aberrations; D018392:Genomic Imprinting; D006801:Humans; D009369:Neoplasms / Q000235:genetics*