title: The effect of preoperative methylprednisolone on pulmonary function and pain after lung operations.
abstract: Thirty-six patients undergoing elective thoracotomy with pulmonary resection with the use of combined epidural and general anesthesia were randomized into a double-blind study to receive a single intravenous preoperative dose of methylprednisolone 25 mg/kg body weight or a placebo (saline solution). Postoperative pain relief consisted of epidural morphine 4 mg and paracetamol 1 gm three times a day for 4 days. Postoperative pulmonary function (peak expiratory flow rate, forced expiratory volume in first second, forced vital capacity) was evaluated on days 1, 2, 3, 4, and 7 and after 1 month. The value obtained after 1 month served as the control value. Pain score at rest and during cough was evaluated after 4 and 8 hours and on days 1, 2, 3, and 4. Pulmonary function was reduced after operation to the same degree in the steroid and placebo group: 42% versus 41% for forced expiratory volume in first second and 38% versus 39% for forced vital capacity, compared with control values after 1 month. Pain score was reduced in the steroid group after 4 hours and on day 1 during rest and after 4 and 8 hours and on day 2 during cough, compared with results in the placebo group (p < 0.05). In the steroid group three patients underwent reoperation because of leakage through the chest wall incision. In conclusion, administration of a single preoperative dose of methylprednisolone did not affect the postoperative reduction in pulmonary function after thoracotomy despite attenuated pain response, and the results do not warrant steroid administration before lung operation.
authors.affiliation: Department of Anesthesiology, Gentofte University Hospital, Copenhagen, Denmark.
authors.forename: D
authors.initials: D
authors.lastname: Bigler
authors.forename: T
authors.initials: T
authors.lastname: Jonsson
authors.forename: J
authors.initials: J
authors.lastname: Olsen
authors.forename: J
authors.initials: J
authors.lastname: Brenøe
authors.forename: K
authors.initials: K
authors.lastname: Sander-Jensen
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000601:surgery; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000517:prevention & control*; D011300:Preoperative Care; D012129:Respiratory Function Tests; D013908:Thoracotomy
chemical_list: D005938:Glucocorticoids; D018696:Neuroprotective Agents; D008775:Methylprednisolone