[Prognostic factors of colon cancer from a molecular biology standpoint].
It has been reported that several genes may be good indicators for determining biological behavior, including the prognosis, of colorectal cancers. We have summarized these reported genes, such as tumor suppressor gene, oncogenes, metastasis suppressor gene, adhesion molecules, growth factors, proteinases, and others, including microsatellite instability. Some of the genes such as p53, DCC, c-met, or matrix metalloproteinase are considered to be reliable for determining biological aggressiveness. We introduced several interesting genes which we are focusing using cDNA subtraction library analysis. We hope that these genes are well combined for best analysis of the biological behavior of colorectal cancers and use for practical clinical analysis. In addition, we hope that novel important genes indicative for prognosis will be found.
Mori
M
M
Dept. of Surgery, Medical Institute of Bioregulation, Kyushu University, Japan.
Mimori
K
K
Tanaka
S
S
Baba
K
K
Kusumoto
H
H
Haraguchi
M
M
Akiyoshi
T
T
D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18; D003110:Colonic Neoplasms / Q000235:genetics*; D019040:E-Selectin / Q000235:genetics; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics; D018895:Microsatellite Repeats; D020559:Monomeric GTP-Binding Proteins; D009154:Mutation; D054778:NM23 Nucleoside Diphosphate Kinases; D019006:Neural Cell Adhesion Molecules / Q000235:genetics; D009701:Nucleoside-Diphosphate Kinase; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2; D014157:Transcription Factors / Q000235:genetics
D019040:E-Selectin; D018960:Hyaluronan Receptors; D054778:NM23 Nucleoside Diphosphate Kinases; D019006:Neural Cell Adhesion Molecules; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014157:Transcription Factors; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins