Non-Hodgkin's lymphoma after liver transplantation: response to chemotherapy.
An increased incidence of lymphoproliferative disorders in immunosuppressed organ transplant recipients has long been recognised. Lymphoproliferative disorders occur in 2% of orthotopic liver transplant patients. Different therapies have been used, but the optimal treatment remains unknown. Relatively little information is available on experience with cytotoxic chemotherapy. Three children who developed Burkitt-like, non-Hodgkin's lymphomas after liver transplantation are described. The disease failed to regress after initial management, which included a reduction in immunosuppression. With cytotoxic chemotherapy all three achieved complete remission, which continued 36+, 35+, and 16+ months after diagnosis. Results suggest that in selected cases chemotherapy can be safe in late-onset lymphomas appearing after solid organ transplantation.
Gallego-Melcón
S
S
Unit of Pediatric Oncology, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, Spain.
Sánchez de Toledo
J
J
Martínez
V
V
Moraga
F
F
Iglesias
J
J
Ruiz
C
C
Allende
E
E
D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male