title: Tetranitromethane as a broad spectrum disinfectant.
abstract: Tetranitromethane (TNM), a protein nitrating reagent, was shown to be effective in killing Gram-positive and Gram-negative bacteria, bacterial endospores and fungi. The killing action was greater in alkaline media, where nitration was most effective. TNM has a high affinity for hydrophobic solvents, and it is suggested that the reagent killed micro-organisms by nitrating critical membrane proteins.
authors.affiliation: Department of Microbiology and Immunology, University of Louisville, Kentucky 40292, USA.
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: G
authors.initials: G
authors.lastname: Sonnenfeld
authors.forename: R J
authors.initials: RJ
authors.lastname: Doyle
mesh_terms: D001419:Bacteria / Q000187:drug effects; D004202:Disinfectants / Q000494:pharmacology*; D013774:Tetranitromethane / Q000494:pharmacology*
chemical_list: D004202:Disinfectants; D013774:Tetranitromethane