[Changes in the myocardium of adult rats when cultured in diffusion chambers in vivo].
Morpho-functional changes of left ventricle myocardium were studied in 30 adult male rats by the method of subcutaneous implantation of diffusion chambers. The transplants were examined in 1, 3, 6, 8 and 10 days after the beginning of cultivation. The method of light microscopy at the 1-2 microm sections was used after histological processing of specimens for the identification of muscle and non-muscle cells and studying of their particular changes. In the muscular fibres there were cardiomyocytes of the destructive, survived and reconstructed forms. It was shown that smooth muscle cells and periocytes are separated from blood microvessels and migrated into the interstitial space. Multinuclear drawing rods formated from activational endotheliocytes were detected between the muscular fibers. Furthermore the cells containing large amount of lipid granules-¿lypophags¿ and the two types of macrophage-like cells were demonstrated. The area of growth including fibroblast-like and spindle-shaped cells were observed around the margins of transplants on the late stages of implantation.
Dedkov
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EI
D000818:Animals; D015194:Diffusion Chambers, Culture; D006352:Heart Ventricles / Q000166:cytology; D008297:Male; D008851:Micropore Filters; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D013997:Time Factors
Izmeneniia miokarda vzroslykh krys pri kul'tivirovanii v diffuzionnykh kamerakh in vivo.