No evidence of a direct venodilatory effect of furosemide in healthy human subjects.
The present study was undertaken to examine whether furosemide, a loop diuretic, has a direct venodilatory effect in healthy male subjects. Furosemide, or amrinone, an inotropic agent with a vasodilatory action, was infused into a dorsal hand vein that had been preconstricted by phenylephrine. The diameter of the vein was measured by a linear variable differential transformer. Venodilation was observed during the infusion of amrinone, but such a response was not detected with furosemide. These findings do not support the hypothesis that furosemide has a direct venodilatory effect in healthy human subjects.
Harada
K
K
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Ohmori
M
M
Fujimura
A
A
Ohashi
K
K
D000328:Adult; D000368:Aged; D000676:Amrinone / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology*; D006225:Hand / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000494:pharmacology*; D014680:Veins / Q000033:anatomy & histology / Q000187:drug effects*
D004232:Diuretics; D014665:Vasodilator Agents; D005665:Furosemide; D000676:Amrinone