Familial supernumerary chromosome and malignancy.
No familial marker chromosome associated with a malignancy has been reported to date. We used fluorescence in situ hybridization (FISH) to characterize a supernumerary marker chromosome 15 ascertained during prenatal diagnosis. This supernumerary chromosome 15 was found to span three generations of a family. Three family members carrying the supernumerary chromosome 15 have also had malignancies, namely, a cystic glioma, leukemia, and thyroid cancer.
Milunsky
J M
JM
Center for Human Genetics, Boston University School of Medicine, Massachusetts 02118, USA.
Wyandt
H E
HE
Milunsky
A
A
D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D005260:Female; D005819:Genetic Markers; D005910:Glioma / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000235:genetics; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D010375:Pedigree; D013964:Thyroid Neoplasms / Q000235:genetics
D005819:Genetic Markers