title: Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat.
abstract: The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 micrograms/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 micrograms/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 micrograms/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of amylin given peripherally was partially reduced. Pre-treatment with domperidone decreased the inhibitory effect of peripherally injected amylin, but no effect was observed when the peptide was centrally injected.
authors.affiliation: Institute of Pharmacology, University of Catania, School of Medicine, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Clementi
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: V M
authors.initials: VM
authors.lastname: Cutuli
authors.forename: E
authors.initials: E
authors.lastname: de Bernardis
authors.forename: A
authors.initials: A
authors.lastname: Prato
authors.forename: M
authors.initials: M
authors.lastname: Amico-Roxas
mesh_terms: D000682:Amyloid / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D005746:Gastric Emptying / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D058228:Islet Amyloid Polypeptide; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D009388:Neostigmine