Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus.
Antitumor activities on Sarcoma 180A of a series of cyclic pentapeptides, astins, isolated from the roots of Aster tataricus, were examined. The activities on various congeners of the dichlorinated proline residues prepared by chemical conversion and a hepatic microsomal biotransformation in rats suggested that 1,2-cis dichlorinated proline residues of astins A, B and C play an important role in the antitumor activity of astins.
Morita
H
H
Department of Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Nagashima
S
S
Uchiumi
Y
Y
Kuroki
O
O
Takeya
K
K
Itokawa
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology*; D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C082413:astin A; C082414:astin B; C096028:astin C