title: Influence of pudendal nerve blockade on stress relaxation in the female urethra.
abstract: The urethral pressure decay following a sudden and sustained dilatation corresponds to stress relaxation. Urethral stress relaxation can be described by the equation Pt = Pequ + P alpha e-t/tau alpha + P beta e-t/tau beta, where Pt is the pressure at time t, Pequ is the equilibrium pressure after dilatation, P alpha and P beta are pressure decay, and tau alpha and tau beta are time constants. The time constants have previously proved independent of the way the dilatation is performed. The urethral stress relaxation obtained in 10 healthy women before and after pudendal nerve blockade was analysed by the mathematical model and the pressure parameters and time constants determined. The fast time constant, tau beta, was reduced by the nerve blockade, whereas tau alpha was unaffected, however, both P alpha and P beta were reduced. No single stress relaxation parameter can therefore be related to the muscle or the connective tissue components. The method may prove useful in the further evaluation of the closure function of the urethra with special reference to the pathophysiology of stress urinary incontinence.
authors.affiliation: Department of Urology, State University Hospital of Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Thind
authors.forename: P
authors.initials: P
authors.lastname: Bagi
authors.forename: C
authors.initials: C
authors.lastname: Mieszczak
authors.forename: G
authors.initials: G
authors.lastname: Lose
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D004338:Drug Combinations; D004548:Elasticity; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D009407:Nerve Block; D009638:Norepinephrine / Q000008:administration & dosage; D011312:Pressure; D013314:Stress, Mechanical; D013566:Sympathomimetics / Q000008:administration & dosage; D014521:Urethra / Q000187:drug effects / Q000294:innervation* / Q000502:physiology*; D014550:Urinary Incontinence, Stress / Q000503:physiopathology
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D013566:Sympathomimetics; D008012:Lidocaine; D009638:Norepinephrine