Isolation of inhibitors of TPA-induced mouse ear edema from Hoelen, Poria cocos.
Triterpene carboxylic acids were isolated from the methanol extract of Hoelen, Poria cocos, and found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced mouse ear edema. Their chemical structures were identified as 3 beta,-16 alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid, 16 alpha-hydroxydehydropachymic acid, 16 alpha-hydroxytrametenolic acid and dehydrotumulosic acid.
Nukaya
H
H
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Yamashiro
H
H
Fukazawa
H
H
Ishida
H
H
Tsuji
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014315:Triterpenes; D013755:Tetradecanoylphorbol Acetate