title: [Cerebral ischemia: ontogenetic differences in energy metabolism and protein biosynthesis].
abstract: OBJECTIVE
  Are ontogenetic differences in the resistance of the brain towards ischemia reflected by differences in the postischemic disturbance of cerebral protein synthesis (PS) independently from energy metabolism (EM)?
  
  
  METHODS
  We studied hippocampal slices from immature (E60) and mature (E60) fetal guinea pigs as well as from adult guinea pigs. Cerebral EM and PS were measured during and up to 24 h after ischemia.
  
  
  RESULTS
  After in vitro ischemia there was no inhibition in cerebral PS in immature fetuses, a transient inhibition in mature fetuses, and a permanent inhibition in adults. During and after in vitro ischemia cerebral EM was hardly disturbed in immature fetuses. No differences in cerebral EM could be observed between mature fetuses and adults.
  
  
  CONCLUSIONS
  Ontogenetic differences in the resistance of the brain towards ischemia are reflected by differences in the postischemic disturbance of cerebral PS. The differences between mature fetuses and adults are independent from cerebral EM.
authors.affiliation: Max-Planck-Institut für Neurologische Forschung, Köln, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: B
authors.initials: B
authors.lastname: Djuricic
authors.forename: A
authors.initials: A
authors.lastname: Jensen
authors.forename: W
authors.initials: W
authors.lastname: Paschen
mesh_terms: D000818:Animals; D046508:Culture Techniques; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005311:Fetal Hypoxia / Q000473:pathology*; D005865:Gestational Age; D006168:Guinea Pigs; D006624:Hippocampus / Q000473:pathology; D002534:Hypoxia, Brain / Q000473:pathology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011247:Pregnancy
chemical_list: D009419:Nerve Tissue Proteins
vernacular_title: Zerebrale Ischämie: Ontogenetische Unterschiede im Energiestoffwechsel und in der Proteinbiosynthese.