Activities of the rodent carcinogens thioacetamide and acetamide in the mouse bone marrow micronucleus assay.
Thioacetamide is confirmed as active in the mouse bone marrow micronucleus assay, following single oral administration to both sexes of two different strains of mice (C57BL/6, BALB/c) in five separate experiments. Acetamide is shown to be consistently and clearly negative as a micronucleus-inducing agent in mouse bone marrow in four repeated assays using different sexes of two strains of mice (C57BL/6, CBA). The present findings support the adequacy of the limited micronucleus test protocol (male animals, two sampling times) for the efficient detection of genotoxic rodent carcinogens in this assay.
Mirkova
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National Center of Hygiene, Ministry of Health, Sofia, Bulgaria.
D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests / Q000379:methods*; D051381:Rats; D013853:Thioacetamide / Q000633:toxicity*
D000081:Acetamides; D002273:Carcinogens; D013853:Thioacetamide; C030686:acetamide