Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats.
Mono-n-benzyl phthalate (MBeP), one of the major metabolites of the plasticizer n-butyl benzyl phthalate, was evaluated for developmental toxicity in Wistar rats. Rats were given MBeP by gastric intubation at 0, 250, 313, 375, 438 or 500 mg/kg from day 7 through day 15 of pregnancy. Significant decreases in the maternal body weight gains and food consumption during administration period were observed at 313 mg/kg and above and at 250 mg/kg and above, respectively. Significant increase in the incidence of postimplantation loss per litter was found at 438 and 500 mg/kg. The incidences of fetuses with external malformations at 438 mg/kg, of fetuses with skeletal malformations at 313 mg/kg and above and of fetuses with internal malformations at 375 mg/kg and above were higher than those in the control group. Defects in the cervical and thoracic vertebrae, ribs and kidney were frequently observed.
Ema
M
M
National Institute of Health Sciences, Osaka Branch, Japan.
Harazono
A
A
Miyawaki
E
E
Ogawa
Y
Y
D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002574:Cervical Vertebrae / Q000002:abnormalities / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D047108:Embryonic Development / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects*; D008297:Male; D010795:Phthalic Acids / Q000008:administration & dosage / Q000633:toxicity*; D010863:Piloerection / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012272:Ribs / Q000002:abnormalities / Q000187:drug effects; D013904:Thoracic Vertebrae / Q000002:abnormalities / Q000187:drug effects
D010795:Phthalic Acids; C032279:phthalic acid