[Effect of puerarin on cerebral blood flow in dogs].
The hemodynamics of left intra- and extracranial arteries was determined by a pulsatile Doppler flowmeter and a transcranial Doppler system simultaneously in anesthetized dogs. Low doses of puerarin (50mg/kg, iv) did not alter the cerebral perfusion pressure, but reduced the flow velocities of both middle cerebral artery and anterior cerebral artery. The globle cerebral blood flow was enhanced due to dilatation of the intracranial arteries.
Chen
L
L
Department of Physiology, Shandong Medical University, Jinan.
Chai
Q
Q
Zhao
A
A
Chai
X
X
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D014665:Vasodilator Agents / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D007529:Isoflavones; D014665:Vasodilator Agents; C033607:puerarin