Glutathione inhibition of silver-enhanced sodium transport across toad skin.
Silver stimulated short-circuit current and transepithelial potential difference. Glutathione inhibited the silver-induced short-circuit current. There was a dose-response inhibition of silver-induced short-circuit current by glutathione. The silver-induced short-circuit current is carried by a net active sodium transfer from the outside to the inside bathing solution.
Gerencser
G A
GA
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA.
Loo
S Y
SY
D000818:Animals; D002024:Bufo marinus; D003545:Cysteine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004566:Electrodes; D005260:Female; D005978:Glutathione / Q000494:pharmacology*; D066298:In Vitro Techniques; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D012834:Silver / Q000037:antagonists & inhibitors*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014667:Vasopressins / Q000494:pharmacology
D014667:Vasopressins; D012834:Silver; D012964:Sodium; D005978:Glutathione; D003545:Cysteine