[Trypanocidal structure- activity relationship in 9-thioalkylacridines].
A set of 9-thioalkylacridinones, has been prepared and investigated "in vitro" against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.
Bsiri
N
N
GERCTOP, URA CNRS, Faculté de Pharmacie, Marseille.
Johnson
C
C
Kayirere
M
M
Galy
A M
AM
Galy
J P
JP
Barbe
J
J
Osuna
A
A
Mesa-Valle
M C
MC
Castilla Calvente
J J
JJ
Rodriguez-Cabezas
M N
MN
D000166:Acridines / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents; D066298:In Vitro Techniques; D051379:Mice; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000166:Acridines; D000981:Antiprotozoal Agents; D014344:Trypanocidal Agents
Relations structure-activité trypanocide chez les 9-thioalkylacridines.