BMP 7 is required for nephrogenesis, eye development, and skeletal patterning.
In summary, the generation of BMP-7-deficient mice has provided additional evidence that this family of growth factors regulate many morphogenetic processes including but not limited to skeletal development. In particular our experiments demonstrate that BMP 7 acts as an early inducer of glomeruli formation, and that it is required for skeletal patterning and lens formation. Our results not only demonstrate that BMP 7 is involved in the differentiation of several organs during development, but also raise the hypothesis that mutations in the Bmp 7 gene itself or in the genetic pathway could be responsible for several human genetic diseases in which glomerulus formation is impaired.
Karsenty
G
G
Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. gkarsenty@molgen.mda.uth.tmc.edu
Luo
G
G
Hofmann
C
C
Bradley
A
A
D000818:Animals; D000853:Anophthalmos / Q000235:genetics; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000196:embryology*; D005124:Eye Abnormalities / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000002:abnormalities* / Q000196:embryology*; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis; D009154:Mutation; D017689:Polydactyly / Q000235:genetics; D011506:Proteins / Q000235:genetics* / Q000502:physiology*; D014034:Toes / Q000002:abnormalities*; D016212:Transforming Growth Factor beta / Q000502:physiology
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011506:Proteins; D016212:Transforming Growth Factor beta