title: Activities of the rodent carcinogens thioacetamide and acetamide in the mouse bone marrow micronucleus assay.
abstract: Thioacetamide is confirmed as active in the mouse bone marrow micronucleus assay, following single oral administration to both sexes of two different strains of mice (C57BL/6, BALB/c) in five separate experiments. Acetamide is shown to be consistently and clearly negative as a micronucleus-inducing agent in mouse bone marrow in four repeated assays using different sexes of two strains of mice (C57BL/6, CBA). The present findings support the adequacy of the limited micronucleus test protocol (male animals, two sampling times) for the efficient detection of genotoxic rodent carcinogens in this assay.
authors.affiliation: National Center of Hygiene, Ministry of Health, Sofia, Bulgaria.
authors.forename: E T
authors.initials: ET
authors.lastname: Mirkova
mesh_terms: D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests / Q000379:methods*; D051381:Rats; D013853:Thioacetamide / Q000633:toxicity*
chemical_list: D000081:Acetamides; D002273:Carcinogens; D013853:Thioacetamide; C030686:acetamide