Oxygen and carbon dioxide requirements of Helicobacter pylori.
The oxygen and carbon dioxide requirements of 25 clinical isolates of Helicobacter pylori were studied in relation to pyruvate metabolism. A maximal number of 16 strains grew without added carbon dioxide under an atmosphere containing 6% oxygen and 0.04% ambient atmospheric carbon dioxide contrary to a generally accepted idea. Enzymes acting on pyruvate as a parameter of the ATP regeneration system were only pyruvate:ferredoxin oxidoreductase (EC 1.2.7.1) and pyruvate formate-lyase (EC 2.3.1.54). The microaerophilism may be partly due to the conversion of pyruvate to acetyl-CoA by the two anaerobic enzymes, although the organism requires oxygen.
Narikawa
S
S
Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan.
Imai
N
N
Yamamoto
M
M
Suzuki
T
T
Yanagawa
A
A
Mizushima
Y
Y
D002245:Carbon Dioxide / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid
D011773:Pyruvates; D002245:Carbon Dioxide; D019289:Pyruvic Acid; D010100:Oxygen