title: 14q+ chromosome marker in a T-cell-rich B-cell lymphoma.
abstract: Cytogenetic, in situ hybridization, and molecular studies were performed in a case of T-cell-rich B-cell lymphoma. Demonstration of Ig gene rearrangements for both heavy and light chains confirmed the B-lineage restriction of the neoplastic cell population. Moreover, as expected in B-cell malignancies, all abnormal karyotypes showed a 14q+ chromosome marker involving 14q32. The origin of the extra material on the derivative 14q+, as defined by chromosome painting with a library for chromosome 11, and Southern blotting for c-myc and bcl-2 rearrangements, remains unknown.
authors.affiliation: Hematology, University of Perugia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: La Starza
authors.forename: A
authors.initials: A
authors.lastname: Aventin
authors.forename: D
authors.initials: D
authors.lastname: Falzetti
authors.forename: M
authors.initials: M
authors.lastname: Stul
authors.forename: M F
authors.initials: MF
authors.lastname: Martelli
authors.forename: B
authors.initials: B
authors.lastname: Falini
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
mesh_terms: D015139:Blotting, Southern; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D005819:Genetic Markers