Anabolic and cardiovascular effects of recombinant human growth hormone in surgical patients with sepsis.
The clinical and metabolic effects of 7 days of recombinant human growth hormone (rhGH) and total parenteral nutrition (TPN) in surgical patients with sepsis were determined in a randomized controlled trial. In patients with a mean(s.e.m.) pretreatment rate of net protein catabolism (NPC) of 1.5 g per kg per day or less rhGH treatment decreased NPC from 0.93(0.14) to -0.20(0.24) g per kg per day (n = 5; P < 0.0005) and rendered these patients anabolic. TPN alone decreased NPC from 1.12(0.11) to 0.61(0.11) g per kg per day (n = 5; P < 0.001). In patients with an initial NPC of more than 1.5 g per kg per day rhGH treatment decreased NPC from 2.72(0.12) to 1.08(0.24) g per kg per day (n = 5; P < 0.001) while TPN alone decreased it from 2.41(0.32) to 1.28(0.28) g per kg per day (n = 5; P < 0.005). Use of rhGH was not associated with any adverse effects or improvement in clinical course but did decrease the mean systolic and diastolic pressures during the study period. Thus rhGH is a useful anabolic agent and may have a role in the haemodynamic management of the catabolic patient with sepsis.
Koea
J B
JB
Department of Surgery, Auckland Hospital, New Zealand.
Breier
B H
BH
Douglas
R G
RG
Gluckman
P D
PD
Shaw
J H
JH
D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011506:Proteins / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D018805:Sepsis / Q000378:metabolism*; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance
D001786:Blood Glucose; D006728:Hormones; D011506:Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone