title: [Cardiomyopathies (VII). Natural history of hypertrophic cardiomyopathy].
abstract: After a short historic review of conceptual developments in hypertrophic cardiomyopathy, the natural history of the disease is analyzed according to each of its morphologic and functional abnormalities. The lack of association between hypertrophic morphology and sudden death is considered. Diastolic dysfunction and LV obstruction, although a frequent cause of dyspnea and heart failure, is not a risk factor for sudden death. Something similar occurs with the infrequent appearance in this disease of contractile failure. Myocardial ischemia is frequent in hypertrophic cardiomyopathy and general prognostic information about it is still lacking. Nevertheless, in young patients with family history of sudden death, a positive Thallium effort test may be a marker of sudden death (without an arrhythmogenic substrate), and may respond to verapamil. Finally, the new knowledge about genetic mutations in hypertrophic cardiomyopathy are analized. We conclude with some futuristic comments about hypertrophic cardiomyopathy.
authors.affiliation: Servico de Cardiología, Hospital 12 de Octubre, Madrid.
authors.forename: C
authors.initials: C
authors.lastname: Sáenz de la Calzada
authors.forename: R
authors.initials: R
authors.lastname: Tello de Meneses
authors.forename: J
authors.initials: J
authors.lastname: Delgado Jiménez
authors.forename: C
authors.initials: C
authors.lastname: Gómez Pajuelo
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez Sánchez
authors.forename: E
authors.initials: E
authors.lastname: González Cocina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003645:Death, Sudden / Q000209:etiology; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D009154:Mutation; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology
vernacular_title: Miocardiopatías (VII). Historia natural de la miocardiopatía hipertrófica.