title: [Assessment of various immunologic parameters in silicone implant carriers].
abstract: The Authors evaluated some immunological parameters in women carrying silicone gel-filled breast implants for over one year. Peripheral blood samples from 22 patients were examined in order to assess both the antigenic pattern of lymphocyte subpopulations by cytofluorimetric analysis, and the cell proliferation of PHA-stimulated lymphocytes by the uptake of tritiated thymidine. These tests were performed at the time of the sample withdrawal and after in vitro reexposure to silicone extract for 48-72h. Changes in lymphocyte subpopulations and functional response were observed when patients were divided into groups according to the type of surgery, i.e. breast augmentation or reconstruction, or to the degree of periprosthetic capsular contracture. These results suggest the possibility of an interaction between silicone and the immune system, which cannot be disregarded for the explanation of the silicone related complications.
authors.affiliation: Laboratorio di Biocompatibilità dei Materiali da Impianto, Istituti Ortopedici Rizzoli, Bologna.
authors.forename: D
authors.initials: D
authors.lastname: Granchi
authors.forename: G
authors.initials: G
authors.lastname: Ciapetti
authors.forename: C R
authors.initials: CR
authors.lastname: Arciola
authors.forename: E
authors.initials: E
authors.lastname: Cenni
authors.forename: L
authors.initials: L
authors.lastname: Savarino
authors.forename: S
authors.initials: S
authors.lastname: Stea
authors.forename: D
authors.initials: D
authors.lastname: Cavedagna
authors.forename: P
authors.initials: P
authors.lastname: Schiavon
authors.forename: R
authors.initials: R
authors.lastname: Giuliani
authors.forename: A
authors.initials: A
authors.lastname: Pizzoferrato
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D015703:Antigens, CD / Q000097:blood*; D018427:Breast Implants; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008875:Middle Aged; D012828:Silicones
chemical_list: D000906:Antibodies; D015703:Antigens, CD; D012828:Silicones
vernacular_title: Valutazione di alcuni parametri immunologici in pazienti portatrici di protesi di silicone.