title: Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection.
abstract: That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.
authors.affiliation: Trudeau Institute, Inc., Saranac Lake, N.Y., USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Johnson
authors.forename: P C
authors.initials: PC
authors.lastname: Sayles
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014124:Toxoplasmosis, Animal / Q000276:immunology*
chemical_list: D007371:Interferon-gamma