Absolute structural determination of stevastelin B.
Stevastelin B, obtained from a culture of a Penicillium sp. NK374186, is a novel depsipeptide containing three amino acids and 3,5-dihydroxy-2,4-dimethylstearic acid. The stereochemistry of the three amino acids was determined by HPLC analysis, and the relative configuration of the 3,5-dihydroxy-2,4-dimethylstearic acid was elucidated by chemical conversion and NMR analysis. The absolute stereochemistry of stevastelin B was determined by synthetic methods.
Shimada
K
K
Research and Development Division, Nippon Kayaku Co., Ltd., Tokyo, Japan.
Morino
T
T
Masuda
A
A
Sato
M
M
Kitagawa
M
M
Saito
S
S
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D005656:Fungal Proteins; D007166:Immunosuppressive Agents / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D005656:Fungal Proteins; D007166:Immunosuppressive Agents; D010455:Peptides; C100705:stevastelin B