[Enzymatic activity of the pancreas and small intestinal mucosa in modelling of toxic hepatitis by administration of heliotrine].
The activity of pancreatic (alpha-amylase, protease, and lipase) and enteral (maltase, glycyl-L-leucine dipeptidase, monoglyceride lipase) was studied in the experiments on adult male Wistar rats weighting 350 +/- 35 g 1-3, 7, 10, 30, 60, and 90 days after injection of a single dose of 25 mg per 100 g body weight. Acute heliotrine intoxication (in a toxic hepatitis model) was shown to lead to a marked decrease in the activities of both pancreatic and intestinal enzymes. It is suggested that the changes may be associated with the direct action of heliotrine on the pancreas and small intestinal mucosa or with hepatic failure.
Karimov
Kh Ia
KhIa
Daniiarov
A N
AN
Usmanov
M M
MM
Demidova
A I
AI
Zul'pikarieva
A N
AN
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000209:etiology; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology; D011763:Pyrrolizidine Alkaloids; D051381:Rats; D017208:Rats, Wistar
D011763:Pyrrolizidine Alkaloids; C010178:heliotrine
Fermentativnaia aktivnost' podzheludochnoĭ zhelezy i slizistoĭ obolochki tonkoĭ kishki pri modelirovanii toksicheskogo gepatita vvedeniem geliotrina.