Proximal gastric vagotomy. Comparison between open and laparoscopic methods in the canine model.
OBJECTIVE
The authors compared open and laparoscopic proximal gastric vagotomies for efficacy of acid reduction and preservation of gastric emptying.


BACKGROUND
Laparoscopic methods have been used to perform vagotomy in patients with duodenal ulcer; however, no direct comparisons are available of laparoscopic and open surgical procedures regarding acid reduction and gastric emptying.


METHODS
Thirty-one consecutive dogs were randomized to open proximal gastric vagotomy (OPGV; n = 11), laparoscopic anterior seromyotomy and posterior truncal vagotomy (ASPTV; n = 10), or laparoscopic proximal gastric vagotomy (LPGV; n = 10). Intraoperative endoscopic Congo red testing assured complete vagotomy. Basal acid output (BAO) and maximal acid output (MAO) during pentagastrin and insulin-induced hypoglycemia were measured with marker dilution techniques, and gastric emptying was assessed with radionuclide-labelled solid and liquid markers before and 5 weeks after operation.


RESULTS
Operative time (mean +/- standard error of the mean) for OPGV was shorter compared with ASPTV and LPGV (86 +/- 7 minutes vs. 124 +/- 7 minutes and 115 +/- 7 minutes; p < 0.002). Postoperative BAO did not decrease in any group. Open proximal gastric vagotomy and LPGV, but not ASPTV, decreased MAO (p < 0.05); (after pentagastrin, OPGV from 26.4 +/- 1.7 mEq/hour to 11.3 +/- 0.1 mEq/hour, LPGV from 21.4 +/- 1.0 mEq/hour to 6.4 +/- 0.5 mEq/hour; after insulin-induced hypoglycemia, OPGV from 9.9 +/- 0.5 mEq/hour to 2.2 +/- 0.3 mEq/hour, LPGV from 7.9 +/- 0.5 mEq/hour to 1.9 +/- 0.4 mEq/hour). Gastric emptying of liquids and solids, as quantitated by the time for one half of the marker to empty (T 1/2) and the shape of the emptying curve, were similar before and after all three surgical procedures.


CONCLUSIONS
Laparoscopic proximal gastric vagotomy was comparable to OPGV in decreasing stimulated gastric acid production without significantly altering gastric emptying. Anterior seromyotomy and posterior truncal vagotomy was less effective in decreasing MAO and required more operative time. Laparoscopic proximal gastric vagotomy has the potential to become accepted therapy for patients with duodenal ulcer managed presently with OPGV.
Kollmorgen
C F
CF
Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Gunes
S
S
Donohue
J H
JH
Thompson
G B
GB
Sarr
M G
MG
D000818:Animals; D003224:Congo Red; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying; D010535:Laparoscopy / Q000379:methods* / Q000401:mortality; D008297:Male; D011897:Random Allocation; D013997:Time Factors; D014629:Vagotomy, Proximal Gastric / Q000379:methods* / Q000401:mortality; D015167:Vagotomy, Truncal / Q000379:methods / Q000401:mortality
D003224:Congo Red