[Mechanism of the radiation-protective effect of indralin].
Pharmacological test demonstrated that radioprotective activity of indralin occurs by interaction with alpha-adrenoreceptor. Radioprotective effect of indralin decreased by alpha-adrenoblocker, aminazine and theophylline. Normobaric hyperoxia during irradiation reduced radioprotective effect of indralin in doses about ED50. In experiment with mice and rats it was shown that indralin induced acute hypoxia, impaired oxygen consumption and heat production by 30-46%, spleen bloodflow to 26.3% of control level, rectal temperature by 1.5-2 degrees C (mouse). After 30-min indralin raised resistance of mice to hypoxic hypoxia that is believed due to rapid development of biochemical adaptive process in hypoxic cells.
Vasin
M V
MV
Chernov
G A
GA
Koroleva
L V
LV
L'vova
T S
TS
Abramov
M M
MM
Antipov
V V
VV
Suvorov
N N
NN
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003037:Cobalt Radioisotopes / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D010636:Phenols / Q000494:pharmacology*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000528:radiation effects; D013154:Spleen / Q000098:blood supply / Q000187:drug effects / Q000528:radiation effects; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors
D003037:Cobalt Radioisotopes; D010636:Phenols; D011837:Radiation-Protective Agents; D011942:Receptors, Adrenergic, alpha; C086896:indralin; D013806:Theophylline; D002746:Chlorpromazine
K mekhanizmu protivoluchevogo deĭstviia indralina.