The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity.
Our findings reviewed in this article have revealed that the stimulation of opioid receptors of the hypothalamic neurons by interferon alpha and beta-endorphin synthesized in the brain or by stress causing the opioid-dependent analgesia suppresses the natural killer cytotoxicity, an important component of immunosurveillance, through an activation of the hypothalamic CRF-sympathetic nervous system.
Hori
T
T
Department of Physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Katafuchi
T
T
Take
S
S
Kaizuka
Y
Y
Ichijo
T
T
Shimizu
N
N
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007031:Hypothalamus / Q000502:physiology*; D007108:Immune Tolerance / Q000502:physiology*; D007111:Immunity, Cellular; D007276:Injections, Intraventricular; D007370:Interferon Type I / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D051381:Rats; D011994:Recombinant Proteins; D013564:Sympathetic Nervous System / Q000502:physiology*
D007370:Interferon Type I; D007375:Interleukin-1; D011994:Recombinant Proteins