Assessing the efficacy of three dentifrices in the treatment of dentinal hypersensitivity.
A multicenter clinical trial conducted by the authors compared the desensitizing efficacy of a new 5 percent potassium nitrate: 0.243 percent sodium fluoride dentifrice along with two clinically proven, commercially available desensitizing dentifrices to a placebo dentifrice. Sensitivity to cold air and tactile stimulation, along with patients' subjective assessments, were evaluated to assess the dentinal desensitizing efficacy of the test dentifrices. Results demonstrated that after four weeks, participants who used the new dentifrice formulation experienced significant decreases in dentinal sensitivity compared to the placebo group for all measured indexes.
Silverman
G
G
International Pharmaceutical Research, Norwalk, Conn, USA.
Berman
E
E
Hanna
C B
CB
Salvato
A
A
Fratarcangelo
P
P
Bartizek
R D
RD
Bollmer
B W
BW
Campbell
S L
SL
Lanzalaco
A C
AC
Mackay
B J
BJ
McClanahan
S F
SF
Perlich
M A
MA
Shaffer
J B
JB
D000328:Adult; D000399:Air Pressure; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003080:Cold Temperature; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D009566:Nitrates / Q000627:therapeutic use; D010147:Pain Measurement; D017680:Potassium Compounds / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013324:Strontium / Q000627:therapeutic use; D014110:Touch
D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D017680:Potassium Compounds; D012969:Sodium Fluoride; C025700:strontium chloride; C023844:potassium nitrate; D013324:Strontium