Cholestasis as a liver protective factor in paracetamol acute overdose.
1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats. 2. Paracetamol plasma concentration and hepatic accumulation decrease about 70-80% in cholestatic rats. 3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded from biochemical and histological findings. These data are correlated with liver and plasmatic paracetamol. 4. These results indicate a decrease in paracetamol toxicity related to stagnant bile.
Acevedo
C
C
Catedra de Farmacologia y Catedra de Fisiopatología, Universidad de Buenos Aires, Argentina.
Bengochea
L
L
Tchercansky
D M
DM
Ouviña
G
G
Perazzo
J C
JC
Lago
N
N
Lemberg
A
A
Rubio
M C
MC
D000082:Acetaminophen / Q000378:metabolism / Q000506:poisoning*; D018712:Analgesics, Non-Narcotic / Q000378:metabolism / Q000506:poisoning*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000139:chemically induced*; D062787:Drug Overdose; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen