L-735,334, a novel sesquiterpenoid potassium channel-agonist from Trichoderma virens.
A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based liquid medium. Its structure was determined on the basis of ms and nmr analysis. It retains distinct biological activity on the high conductance calcium-activated potassium channel, unlike its analogues 14-hydroxy CAF-603, CAF-603 3-oleate, or CAF-603 3-linoleate.
Lee
S H
SH
Department of Natural Products Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA.
Hensens
O D
OD
Helms
G L
GL
Liesch
J M
JM
Zink
D L
DL
Giacobbe
R A
RA
Bills
G F
GF
Stevens-Miles
S
S
Garcia
M L
ML
Schmalhofer
W A
WA
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D002417:Cattle; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000819:agonists* / Q000187:drug effects; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014242:Trichoderma / Q000737:chemistry*
C100473:L 735334; D015221:Potassium Channels; D012717:Sesquiterpenes; D002118:Calcium