Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder.
Hormonal responses to challenge with the 5-HT2A/2C probe d-fenfluramine and hormonal and thermal responses to challenge with the 5-HT1A probe ipsapirone were correlated with self-report and historical assessments of aggression in a pilot sample of eight male personality-disordered individuals. Prolactin responses to d-fenfluramine and cortisol responses to ipsapirone challenge were inversely correlated with self-reported assaultiveness. Thermal responses to ipsapirone were inversely correlated with a historical assessment of aggression. Since none of these physiological indices of 5-HT system function were intercorrelated, it is possible that simultaneous assessment of these 5-HT indices may yield a more comprehensive assessment of the relationship between central 5-HT system function and aggressive behavior in humans.
Coccaro
E F
EF
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia, USA.
Kavoussi
R J
RJ
Hauger
R L
RL
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D001519:Behavior / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000188:drug therapy* / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; D005277:Fenfluramine; D012701:Serotonin; C043077:ipsapirone