Effects of sympathetic inhibition on receptive, proceptive, and rejection behaviors in the female rat.
The present investigation was designed to examine the effects of sympathetic nervous system (SNS) inhibition on sexual behavior in ovariectomized, steroid-treated female rats. Clonidine, an alpha2-adrenergic agonist, guanethidine, a postganglionic noradrenergic blocker, and naphazoline, an alpha2-adrenoreceptor agonist were used to inhibit SNS activity. Intraperitoneal injections of either 33 micrograms/ml or 66 micrograms/ml clonidine significantly decreased receptive (lordosis) and proceptive (ear wiggles) behaviors and significantly increased rejection behaviors (vocalization, kicking, boxing). Either 25 mg/ml or 50 mg/ml guanethidine significantly decreased receptive and proceptive behavior and had no significant effect on rejection behaviors. Naphazoline significantly inhibited lordosis behavior at either 5 mg/ml or 10 mg/ml doses, significantly inhibited proceptive behavior at 5 mg/ml, and had no significant effect on rejection behaviors. These findings support the hypothesis that SNS inhibition decreases sexual activity in the female rat.
Meston
C M
CM
Department of Psychology, University of British Columbia, Vancouver, Canada.
Moe
I V
IV
Gorzalka
B B
BB
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D008297:Male; D009278:Naphazoline / Q000494:pharmacology; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D010052:Ovariectomy; D011187:Posture / Q000502:physiology; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D013565:Sympatholytics; D009278:Naphazoline; D003000:Clonidine; D009638:Norepinephrine; D006145:Guanethidine