[Establishment of reference intervals and physiological parameters for 13 serum proteins in healthy Japanese adults].
Using a nephelometry with a new calibrator in which values were assigned from EU/CRM470, a new international reference preparation, we have established for the first time the reference intervals of 13 different serum proteins in Japanese adults. Based on the NCCLS guideline C28-P, a new statistical and concrete procedure was revised and used for this study. It is clearly shown here that standardisation of serum proteins can be possible under the qualified assay system, making it possible to share the reference intervals among laboratories under well-controlled quality assurance. New aspects of serum protein variations were discovered in relation to physiologic changes and life styles.
Kawai
T
T
Department of Clinical Pathology, Jichi Medical School, Tochigi, Japan.
Itoh
Y
Y
Hirabayashi
Y
Y
Ichihara
K
K
Igarashi
S
S
Iwata
S
S
Kawano
K
K
Kanno
T
T
Ohkubo
A
A
Saitoh
K
K
Sugahara
T
T
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012907:Smoking / Q000097:blood
D001798:Blood Proteins