title: [Therapeutic trials with topical capsaicin cream and iontophoretically applied lidocaine for diabetic painful truncal neuropathy].
abstract: We report a 63-year-old man with a history of diabetes mellitus for 23 years. Painful dysesthesia developed in his toes and trunk with weight loss of 2kg in two months, after the therapy for diabetes mellitus. Truncal painful dysesthesia was symmetrically distributed in the bilateral posterior and anterior T8-11 dermatomes, sparing the bilateral lateral tholacic areas. Electromyography showed denervation potentials in bilateral abdominal rectus muscles at the levels of Th8-10. Histopathological study of the biopsied right sural nerve revealed small fiber neuropathy. We suspected the truncal painful dysesthesia of this patient resulted from diabetic small fiber polyneuropathy, which was resistant to ordinary medical treatments such as non-steroidal anti-inflammatory drugs. Capsaicin cream containing 0.075% capsaicin, and lidocaine delivered by iontophoresis were both effective for his painful dysesthesia.
authors.affiliation: Department of Neurology, Yokohama Rosai Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: F
authors.initials: F
authors.lastname: Takao
authors.forename: M
authors.initials: M
authors.lastname: Kunimoto
authors.forename: K
authors.initials: K
authors.lastname: Inoue
mesh_terms: D002211:Capsaicin / Q000008:administration & dosage*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D006801:Humans; D006941:Hyperesthesia / Q000188:drug therapy; D007478:Iontophoresis; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010146:Pain / Q000188:drug therapy
chemical_list: D009824:Ointments; D008012:Lidocaine; D002211:Capsaicin