Comparison of eltanolone and propofol on a pressure-volume analysis of the heart.
We designed a randomized study to compare the effect of eltanolone and propofol on cardiac contractility. Patients were anesthetized, tracheally intubated and ventilation controlled. Propofol, 1.25 or 2.5 mg/kg, or eltanolone, 0.5 or 1 mg/kg, or a lipid emulsion only was administered in an intravenous (i.v.) bolus dose. Pressure-volume analysis was used based on radial artery pressure and transesophageal left ventricular cross-sectional area. Both propofol and eltanolone have negative inotropic properties in humans. We conclude that equianesthetic doses of these drugs produce similar changes in myocardial contractility.
Mulier
J P
JP
Department of Anesthesiology and Intensive Care Medicine, AZ St. Jan, Brugge, Belgium.
Van Aken
H
H
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D001810:Blood Volume / Q000187:drug effects; D002306:Cardiac Volume / Q000187:drug effects*; D003864:Depression, Chemical; D017548:Echocardiography, Transesophageal; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000494:pharmacology; D007442:Intubation, Intratracheal; D009200:Myocardial Contraction / Q000187:drug effects; D011280:Pregnanolone / Q000008:administration & dosage* / Q000494:pharmacology; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology; D017534:Radial Artery; D012121:Respiration, Artificial; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects
D018686:Anesthetics, Intravenous; D005217:Fat Emulsions, Intravenous; D006993:Hypnotics and Sedatives; D011280:Pregnanolone; D015742:Propofol