title: [Comparative study of the costs for two hematopoietic cell specimen collections: cytapheresis and bone marrow collection].
abstract: The aim of this study, carried out at the Institut Paoli-Calmettes (Marseille-France), was to compare, in terms of monetary and non monetary costs, alternate procedures for hematopoietic stem cells collection i.e. peripheral blood stem cells collection (PBSCC) and bone marrow collection (BMC) used in cancer therapies. Monetary costs have been evaluated by calculating the direct costs of the two types of procedures and non monetary costs by comparing anxiety, discomfort and pain of cancer patients submitted to PBSCC or BMC. Patients, randomized (7/1993-2/1994), in view of autologous transplantation, to receive the first procedure or the second one received three self-administered questionnaires to complete before, during and after the procedure. Pain was assessed using visual analogical scale and McGill Pain questionnaire. Anxiety was evaluated by means of State-Trait Anxiety Inventory. Results showed that, under some conditions, presently realized in the current practice, direct costs of PBSCC (10,140 to 13,780 FF) were lower than BMC ones (16,509 FF) and that anxiety and pain experienced by patients submitted to PBSCC, with or without femoral catheter, were significantly less severe than in other group patients (State anxiety, before procedure : p < 0.01 ; pain related to the procedure assessed on VAS : p < 0.001 and total McGill score : p < 0.00001). These findings justify the substitution of bone marrow transplantation by peripheral blood stem cells transplantation, provided there is a demonstration of similar medical efficacy for cancer therapy.
authors.affiliation: INSERM, Unité 379, Institut Paoli-Calmettes, Marseille.
authors.forename: A G
authors.initials: AG
authors.lastname: Le Corroller
authors.forename: G
authors.initials: G
authors.lastname: Macquart-Moulin
authors.forename: P
authors.initials: P
authors.lastname: Auquier
authors.forename: C
authors.initials: C
authors.lastname: Faucher
authors.forename: C
authors.initials: C
authors.lastname: Chabannon
authors.forename: J L
authors.initials: JL
authors.lastname: Blache
authors.forename: D
authors.initials: D
authors.lastname: Blaise
authors.forename: G
authors.initials: G
authors.lastname: Novakovitch
authors.forename: D
authors.initials: D
authors.lastname: Maraninchi
authors.forename: J P
authors.initials: JP
authors.lastname: Moatti
mesh_terms: D000328:Adult; D001007:Anxiety / Q000209:etiology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000191:economics*; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D004180:Direct Service Costs; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000191:economics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D010146:Pain / Q000209:etiology*; D013048:Specimen Handling / Q000009:adverse effects / Q000191:economics; D011795:Surveys and Questionnaires; D014182:Transplantation, Autologous
vernacular_title: Etude comparative des coûts de deux procédures de recueil des cellules souches hématopoïétiques : la cytaphérèse et le prélèvement de moelle osseuse.