title: Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.
abstract: Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.
authors.affiliation: Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Sebring
authors.forename: J J
authors.initials: JJ
authors.lastname: Esch
authors.forename: M E
authors.initials: ME
authors.lastname: Kraus
authors.forename: K
authors.initials: K
authors.lastname: Vorwerk
authors.forename: J
authors.initials: J
authors.lastname: Magee
authors.forename: S B
authors.initials: SB
authors.lastname: Carroll
mesh_terms: D000818:Animals; D001483:Base Sequence; D004247:DNA; D018983:DNA Footprinting; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D004742:Enhancer Elements, Genetic; D018507:Gene Expression Regulation, Developmental; D007301:Insect Hormones / Q000502:physiology; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology; D015398:Signal Transduction; D014921:Wings, Animal / Q000196:embryology*
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; D009687:Nuclear Proteins; D012097:Repressor Proteins; C088731:Su(H) protein, Drosophila; C064196:dpp protein, Drosophila; C095064:vg protein, Drosophila; D004247:DNA