title: The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism.
abstract: OBJECTIVE
  To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism.
  
  
  METHODS
  Nonrandomized, prospective clinical trial.
  
  
  METHODS
  Forty-one patients with moderate-severe hirsutism were included in the study.
  
  
  METHODS
  Hirsute patients received 250 mg/d flutamide for a period of 6 months.
  
  
  METHODS
  Hirsutism score, FSH, LH, E2, total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment.
  
  
  RESULTS
  Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48 +/- 5.35 to 5.07 +/- 2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study.
  
  
  CONCLUSIONS
  The low-dose flutamide, 250 mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750 mg/d.
authors.affiliation: Erciyes University, Faculty of Medicine, Kayseri, Turkey.
authors.forename: I I
authors.initials: II
authors.lastname: Müderris
authors.forename: F
authors.initials: F
authors.lastname: Bayram
authors.forename: Y
authors.initials: Y
authors.lastname: Sahin
authors.forename: F
authors.initials: F
authors.lastname: Keleştimur
authors.forename: A
authors.initials: A
authors.lastname: Tutuş
authors.forename: D
authors.initials: D
authors.lastname: Ayata
mesh_terms: D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000735:Androstenedione / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000097:blood; D005260:Female; D005485:Flutamide / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood
chemical_list: D000726:Androgen Antagonists; D004967:Estrogens; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D005485:Flutamide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone