title: [Morphologic aspects of alloplastic augmentation in replacement of the posterior cruciate ligament. An experimental study on the sheep].
abstract: The treatment of injuries to the posterior cruciate ligament (PCL) remains controversial. Various problems have prevented PCL reconstruction from consistently producing the knee stability desired. Biological graft tissue undergoes a remarkable healing process comprising different phases. The strength of autogenous graft material decreases soon after the operation. During this early healing phase synthetic augmentation could protect the graft tissue from overloading or overstretching, supporting the tissue restoration process. In order to evaluate the morphological effects of the ligament augmentation device (LAD) on a free patellar tendon autograft in PCL reconstruction a comparative study in sheep was conducted. In 24 mature sheep the PCL was replaced with either a patellar tendon autograft alone or a patellar tendon autograft augmented by the LAD. The LAD was fixed at both ends. The animals were not immobilized after the operation. Tibial fixation was released 8 weeks after the operation. The autografts of both groups were histologically evaluated after 2, 6, 16, 26, 52 and 104 weeks. In addition to necrotic and degenerative alterations a pronounced inflammatory reaction could be seen in the LAD-augmented autografts soon after the operation. Compared with the non-augmented autograft, tissue formation and remodeling was delayed in the augmented group. After 1 and 2 years, the morphology of the autograft tissue was similar in the augmented and the non-augmented group and was different from that of a normal PCL. The LAD was surrounded by a chronic inflammatory reaction, and collagen fiber ingrowth into the LAD was not observed. Transmission electron microscopy showed that small-diameter collagen fibrils were predominant in the graft tissue of both groups. Thus, better remodeling of the autograft tissue in the presence of the LAD was not demonstrable in this particular study. The value of synthetic augmentation of biological grafts of PCL reconstruction seems to be questionable at present.
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover.
authors.forename: U
authors.initials: U
authors.lastname: Bosch
authors.forename: W J
authors.initials: WJ
authors.lastname: Kasperczyk
authors.forename: B
authors.initials: B
authors.lastname: Decker
authors.forename: H J
authors.initials: HJ
authors.lastname: Oestern
authors.forename: H
authors.initials: H
authors.lastname: Tscherne
mesh_terms: D000818:Animals; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D007718:Knee Injuries / Q000473:pathology / Q000601:surgery*; D011126:Polypropylenes; D016119:Posterior Cruciate Ligament / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D019736:Prostheses and Implants; D012756:Sheep; D013709:Tendon Transfer; D014945:Wound Healing / Q000502:physiology
chemical_list: D011126:Polypropylenes
vernacular_title: Morphologische Aspekte der alloplastischen Augmentation beim Ersatz des hinteren Kreuzbandes. Eine experimentelle Studie am Schaf.