title: Akathisia following low-dose droperidol for antiemesis in day-case patients.
abstract: Akathisia has been described following the use of droperidol for antiemetic prophylaxis. In a double-blind, placebo-controlled study, we investigated both the incidence of akathisia and its relationship to the dose of droperidol (0.5 or 1 mg). One hundred and twenty healthy women undergoing day-case gynaecological surgery were anaesthetised with propofol, fentanyl, isoflurane and droperidol according to group. Patients were assessed by structured telephone interview at 24 h. There was an increasing incidence of both restlessness (p = 0.01) and unpleasant restlessness (p = 0.02) between the groups on Chi-squared testing. Compared to the control group, those women given droperidol 1 mg suffered more restlessness (p = 0.001) and unpleasant restlessness (p < 0.01). No statistical difference could be demonstrated between the two droperidol groups. We conclude that droperidol may commonly cause akathisia and may not, therefore, be an appropriate prophylactic antiemetic for day-case anaesthesia.
authors.affiliation: Department of Anaesthetics, Royal Preston Hospital.
authors.forename: P N
authors.initials: PN
authors.lastname: Foster
authors.forename: B R
authors.initials: BR
authors.lastname: Stickle
authors.forename: A S
authors.initials: AS
authors.lastname: Laurence
mesh_terms: D000328:Adult; D017109:Akathisia, Drug-Induced / Q000209:etiology*; D000556:Ambulatory Surgical Procedures; D000932:Antiemetics / Q000009:adverse effects*; D004311:Double-Blind Method; D004329:Droperidol / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D014839:Vomiting / Q000517:prevention & control
chemical_list: D000932:Antiemetics; D004329:Droperidol