title: Unusual endometrial stromal cell changes mimicking metastatic carcinoma.
abstract: We report an unusual histopathologic finding in the endometrium from six premenopausal or perimenopausal patients who underwent biopsy for abnormal uterine bleeding. In each case the endometrial stromal cells focally exhibited a pronounced epithelioid appearance; some showed a cord-like trabecular pattern and others a signet-ring-like cell change. All raised the possibility of a metastatic malignancy, particularly from the breast. The epithelioid appearance of the stromal cells appears to be an unusual artifact occurring in a background of secretory change and predecidualization with nonmenstrual breakdown.
authors.affiliation: Department of Pathology, Hutzel Hospital, Detroit, MI, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Jacques
authors.forename: F
authors.initials: F
authors.lastname: Qureshi
authors.forename: N C
authors.initials: NC
authors.lastname: Ramirez
authors.forename: W D
authors.initials: WD
authors.lastname: Lawrence
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000328:Adult; D001706:Biopsy; D018275:Carcinoma, Lobular / Q000473:pathology* / Q000556:secondary; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000556:secondary; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017154:Stromal Cells / Q000473:pathology; D014592:Uterine Hemorrhage / Q000473:pathology