Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities.
New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 microM, respectively.
Omura
S
S
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Inokoshi
J
J
Uchida
R
R
Shiomi
K
K
Masuma
R
R
Kawakubo
T
T
Tanaka
H
H
Iwai
Y
Y
Kosemura
S
S
Yamamura
S
S
D019883:Alkyl and Aryl Transferases; D000730:Androstadienes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D051231:Farnesyltranstransferase; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium; D014166:Transferases / Q000037:antagonists & inhibitors*
D000730:Androstadienes; C100395:andrastin A; C100396:andrastin B; C100397:andrastin C; D014166:Transferases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase