[Lipid peroxidation and protein glycosylation in the aorta of rabbits with alloxan diabetes during insulin correction].
The pathogenesis of angiopathic complications was studied in rabbits with alloxan diabetes treated with insulin. The latter was found to affect lipid peroxidation, while the levels of glycosylated proteins remained increased in the aortic wall and red blood cells. It is concluded that enhanced nonenzymatic protein glycosylation in a patient with diabetes mellitus may be one of the factors predisposing to angiopathic complications in diabetes mellitus, irrespective of insulin therapy.
Khegaĭ
M D
MD
Zaĭchik
S E
SE
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000188:drug therapy* / Q000503:physiopathology; D006031:Glycosylation; D007328:Insulin / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011817:Rabbits
D007328:Insulin
Perekisnoe okislenie lipidov i glikozilirovanie belkov v aorte krolikov s alloksanovym diabetom pri insulinokorrektsii.