[Increased serum level of c-erbB-2-coded protein p105 in patients with pre-eclampsia].
OBJECTIVE
This study investigated p105 serum levels in normal pregnancies and in preeclamptic women.


METHODS
The p105 serum level was determined in 65 women with normal pregnancy and 25 preeclamptic women.


RESULTS
The mean p105 serum level for the control group was 102-333 fmol/ml (median 163 fmol/ml). Preeclamptic women had significant higher serum levels (97-368 fmol/ml, median 202 fmol/ml, p < 0,005).


CONCLUSIONS
Elevated serum levels of the c-erbB-2-encoded protein p105 in preeclamptic women could be the result of endothelial dysfunction in preeclampsia.
Meden
H
H
Universitäts-Frauenklinik Göttingen.
Mielke
S
S
Wuttke
W
W
Kuhn
W
W
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood*; D012016:Reference Values
D010446:Peptide Fragments; D018719:Erb-b2 Receptor Tyrosine Kinases
Erhöhte Serumspiegel des c-erbB-2-codierten Proteins p105 bei Patientinnen mit Präeklampsie.