title: Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver.
abstract: The state of DNA methylation in the c-fos gene was examined in human livers of different ages, cirrhosis and hepatocellular carcinoma. The degree of methylation in the intron 1 to exon 4 region increased with age, whereas all of the 10 cirrhosis samples revealed a decrease in methylation when compared to normal livers of similar ages. The 11 hepatocellular carcinomas showed varied alterations suggesting that the alteration of the c-fos gene methylation is related to aging as well as to early-step of hepatocarcinogenesis.
authors.affiliation: Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: E K
authors.initials: EK
authors.lastname: Choi
authors.forename: S
authors.initials: S
authors.lastname: Uyeno
authors.forename: N
authors.initials: N
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Okumoto
authors.forename: S
authors.initials: S
authors.lastname: Fujimura
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Nata
authors.forename: K
authors.initials: K
authors.lastname: Sagisaka
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuda
authors.forename: K
authors.initials: K
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Ono
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000378:metabolism*; D005260:Female; D016762:Genes, fos; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008745:Methylation; D008875:Middle Aged
chemical_list: D004247:DNA