title: Is peritoneal permeability an adverse risk factor for malnutrition in CAPD patients?
abstract: In light of the correlation between the dialysate to plasma ratio of creatinine (D/P Cr), peritoneal (PD) protein loss and hypoalbuminaemia, peritoneal permeability has been implicated as a risk factor for malnutrition in CAPD patients. However, serum albumin is also affected by hydration which is itself influenced by peritoneal permeability. In a cross-sectional study of 147 CAPD patients we investigated the relationship between peritoneal permeability, PD protein loss and nutritional state. Stepwise regression analysis revealed D/P Cr to be the only significant predictor of serum albumin independent of PD protein loss. No significant relationship was demonstrated between D/P Cr, body fat, lean muscle mass and dietary protein intake. Increased peritoneal permeability does not cause hypoalbuminaemia as a consequence of increased PD protein loss, and does not adversely affect somatic fat and protein status.
authors.affiliation: Renal Unit, Manchester Royal Infirmary, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Harty
authors.forename: H
authors.initials: H
authors.lastname: Boulton
authors.forename: M C
authors.initials: MC
authors.lastname: Venning
authors.forename: R
authors.initials: R
authors.lastname: Gokal
mesh_terms: D000704:Analysis of Variance; D000886:Anthropometry; D001798:Blood Proteins / Q000378:metabolism; D001823:Body Composition; D003404:Creatinine / Q000378:metabolism; D003430:Cross-Sectional Studies; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology; D009748:Nutrition Disorders / Q000453:epidemiology* / Q000209:etiology; D010529:Peritoneal Cavity; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010539:Permeability; D011228:Prealbumin / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012044:Regression Analysis; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D011228:Prealbumin; D011506:Proteins; D012709:Serum Albumin; D003404:Creatinine