title: A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects.
abstract: A patient is presented who had Castleman's disease with constitutional symptoms, a palpable supraclavicular/ axillar mass, and a microcytic anemia, among other laboratory abnormalities, including elevated levels of interleukin-6. Treatment consisted of irradiation of the involved area, with subsequent disappearance of all symptoms and normalization of the laboratory abnormalities. Iron kinetic studies demonstrated a hypoproliferative erythropoiesis, which normalized after radiotherapy. Hypoproliferative erythopoiesis could not be ascribed to serum inhibitors, since normal burst-forming units were observed in the absence or presence of autologous serum. The role of interleukin-6 in relation to Castleman's disease is highlighted.
authors.affiliation: Department of Internal Medicine, University Hospital Groningen, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Veldhuis
authors.forename: A H
authors.initials: AH
authors.lastname: van der Leest
authors.forename: J T
authors.initials: JT
authors.lastname: de Wolf
authors.forename: E G
authors.initials: EG
authors.lastname: de Vries
authors.forename: E
authors.initials: E
authors.lastname: Vellenga
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male