Effect of vitamin K2 on experimental calcinosis induced by vitamin D2 in rat soft tissue.
The effect of vitamin K2 on calcium (Ca) and inorganic phosphorus (P) levels in the aorta and kidney obtained from experimental calcinosis induced by vitamin D2(2.5 x 10(5) I.U./ kg b.w.) of male rats was investigated. A high dose of vitamin K2 (100 mg/kg b.w.) inhibited the increase in the aortic Ca and P or in the renal Ca and P induced by vitamin D2, and a low dose of vitamin K2 (10 mg/kg b.w.) showed the same tendency, but the degree of the efficacy was small. It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. Therefore, a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of arteriosclerosis with calcification.
Seyama
Y
Y
Dept. of Clinical Chemistry, Hoshi College of Pharmacy, Tokyo, Japan.
Horiuch
M
M
Hayashi
M
M
Kanke
Y
Y
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002114:Calcinosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004872:Ergocalciferols; D007668:Kidney / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014812:Vitamin K / Q000008:administration & dosage* / Q000627:therapeutic use*
D004872:Ergocalciferols; D014812:Vitamin K; D010758:Phosphorus; D002118:Calcium