title: The biological effectiveness of radon-progeny alpha particles. V. Comparison of oncogenic transformation by accelerator-produced monoenergetic alpha particles and by polyenergetic alpha particles from radon progeny.
abstract: Generation of estimates of risk caused by exposure to radon in the home, either from miner data or from A-bomb data, requires several scaling factors such as for dose, dose rate and radiation quality, and possible synergisms. Such scaling factors are best developed from laboratory-based studies. Two possible sources of alpha particles for such studies are (1) a polyenergetic spectrum, generated directly by radon and its progeny, or (2) a series of monoenergetic alpha particles. We compare here the results of oncogenic transformation from studies using both systems. At the Columbia University Radiological Research Accelerator Facility (RARAF), C3H 10T1/2 cells were irradiated with alpha particles of various energies, with defined LETs from 70 to 200 keV/mum. At Pacific Northwest Laboratory, cells from the same stock were exposed to alpha particles from radon gas and its progeny, which were in equilibrium with the culture medium. There was good agreement between the results of oncogenic transformation experiments using the two different exposure systems. Apart from the experimental transformation frequencies themselves, such a comparison requires (1) reliable dosimetry at both facilities and (2) estimated LET distributions for the polyenergetic alpha-particle irradiator. Thus this good agreement gives some confirmation to the technique which is used to fold together oncogenic transformation rates from monoenergetic alpha particles to yield a predicted rate for a spectrum of alpha particles.
authors.affiliation: Center for Radiological Research, Columbia University, New York, New York 10032, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Richards
authors.forename: D J
authors.initials: DJ
authors.lastname: Brenner
authors.forename: E J
authors.initials: EJ
authors.lastname: Hall
authors.forename: R
authors.initials: R
authors.lastname: Jostes
authors.forename: T E
authors.initials: TE
authors.lastname: Hui
authors.forename: A L
authors.initials: AL
authors.lastname: Brooks
mesh_terms: D000512:Alpha Particles; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D008809:Mice, Inbred C3H; D010315:Particle Accelerators; D011886:Radon / Q000009:adverse effects*
chemical_list: D011886:Radon