title: Fragmentation hemolysis: an unusual indication for valve replacement in native valve infective endocarditis.
abstract: Intravascular mechanical fragmentation of erythrocytes is an uncommon occurrence in native valve infective endocarditis. We report a case of fragmentation hemolysis in a patient with tricuspid valve endocarditis due to Staphylococcus aureus. She received transfusion of multiple units of packed red blood cells and ultimately required surgical removal of the affected valve to control the hemolytic process. We believe this to be only the fifth such reported case and the first in which surgical therapy was necessary to control the hemolytic process.
authors.affiliation: Department of Medicine, Sinai Hospital, Baltimore, MD 21215, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Gradon
authors.forename: M
authors.initials: M
authors.lastname: Hirschbein
authors.forename: J
authors.initials: J
authors.lastname: Milligan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D001803:Blood Transfusion; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D013203:Staphylococcal Infections / Q000150:complications* / Q000601:surgery; D013211:Staphylococcus aureus; D015819:Substance Abuse, Intravenous / Q000150:complications; D014261:Tricuspid Valve