Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation.
A combination of Southern blot analysis on a panel of tumor-derived somatic cell hybrids and fluorescence in situ hybridization (FISH) techniques was used to map a series of DNA markers relative to the 1q21 breakpoint of the renal cell carcinoma (RCC)-associated (X;1)-(p11;q21) translocation. This breakpoint maps between several members of the S100 family which are clustered in the 1q21 region and a conserved region between man and mouse containing the markers SPTA1-CRP-APCS-FcER1A-ATP1A2-APOA2. The location of the breakpoint coincides with the transition of a region of synteny of human chromosome 1 with mouse chromosomes 3 and 1.
Weterman
M A
MA
Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
Wilbrink
M
M
Dijkhuizen
T
T
van den Berg
E
E
Geurts van Kessel
A
A
D000818:Animals; D015139:Blotting, Southern; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D006224:Cricetinae; D015342:DNA Probes; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured; D014960:X Chromosome / Q000235:genetics*
D015342:DNA Probes; D005819:Genetic Markers