Thrombin-antithrombin III complexes as an additional diagnostic aid in pulmonary embolism.
Plasma levels of selected coagulation and fibrinolytic parameters (activated partial thromboplastin time, prothrombin time, fibrinogen, antithrombin III, protein C, thrombin-anti-thrombin III complexes (TAT), plasminogen activator inhibitor-1 (PAI-1), plasminogen, alpha 2-plasmin inhibitor) were evaluated in 90 patients with clinical suspicion of pulmonary embolism (PE). Plasma levels of fibrinogen, PAI-1 and TAT were significantly higher in patients than in controls (p < 0.01): evaluation of TAT displayed a sensitivity of 96.1% and specificity of 30.8%, and positive and negative predictive values of 64.5 and 85.7%, respectively. The number of nonperfused lung segments correlated directly with TAT levels (p < 0.01) and inversely with arterial pO2 values (p < 0.01). No significant difference was found in the other parameters between patients and controls. Our results suggest that the finding of normal TAT plasma levels can help to exclude PE in patients with clinically suspected PE.
Carmassi
F
F
2nd-Medical Clinic, CNR Institute of Clinical Physiology, University of Pisa, Italy.
Morale
M
M
de Negri
F
F
Puccetti
R
R
Pistelli
F
F
Mariani
G
G
Pazzagli
M
M
Palla
A
A
Giuntini
C
C
D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III; D001780:Blood Coagulation Tests; D005069:Evaluation Studies as Topic; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis*
C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases