title: Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula.
abstract: Seven new sesquiterpenes, majapolenes A [1] and B [2], majapolone [3], and majapols A [4], B [5], C [6], and D [7], were isolated from a Philippine collection of Laurencia majuscula. With the exception of majapolene B [2], all compounds were isolated as inseparable diastereomeric mixtures. Structure elucidation was achieved by spectroscopic methods. Majapolene A [1], a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of Laurencia caraibica.
authors.affiliation: Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Erickson
authors.forename: J A
authors.initials: JA
authors.lastname: Beutler
authors.forename: G N
authors.initials: GN
authors.lastname: Gray
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D000461:Rhodophyta / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D012717:Sesquiterpenes; C100474:majapolene A