Eczematous-like drug eruption induced by synergistins.
The authors report 4 cases of eczematous-like drug eruption after oral ingestion of synergistins, pristinamycin (3 cases) and virginiamycin (1 case). The lesions occurred after contact sensitization with topical virginiamycin. The clinical symptoms appeared a few hours after ingestion: a generalized maculopapular eruption, sometimes with general symptoms of anaphylactic reaction. Eczema appeared again on initial areas of contact dermatitis. There is a common allergenic group between these 2 antibiotics, which is a macrocyclic lactone. Physiopathology of this drug eruption is not clear: allergic reaction of the delayed type or anaphylactic reaction. Patients allergic to virginiamycin should be strongly cautioned against oral pristinamycin.
Michel
M
M
Service de Dermatologie Centre Hospitalier Universitaire, Caen, France.
Dompmartin
A
A
Szczurko
C
C
Castel
B
B
Moreau
A
A
Leroy
D
D
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D017443:Skin Diseases, Eczematous / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014769:Virginiamycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D014769:Virginiamycin