[Measuring the concentration of various plasma and placenta extract proteolytic and vascular factors in pregnant patients with HELLP syndrome, pre-/eclampsia and highly pathologic Doppler flow values].
OBJECTIVE
Impaired trophoblast invasion plays a major role in the development of preeclampsia. Therefore various factors that are involved in invasion were investigated in gestational disease.


METHODS
In pregnant women with HELLP-syndrome (n = 18), pre-/eclampsia (n = 21) and highly pathological Doppler flow measurements (hpD) (n = 13), plasma and placental tissue extract concentrations of uPA, uPA-receptor, tPA, PAI-1, MMP-8, MMP-9, TIMP-1, thrombomodulin, and angiogenin were measured using ELISA.


RESULTS
In all three collectives, PAI-1 plasma concentrations were significantly higher (p < 0,05) than in normal pregnancies, in patients with HELLP-syndrome, tPA and TIMP-1 plasma levels were also elevated. MMP-9 concentrations in placental tissue extracts were lower in pre-/eclampsia than in normal pregnancies.


CONCLUSIONS
Impaired placental implantation and remodelling in gestational disease is reflected by changes in plasma and placental tissue extract concentrations of various factors that are involved in these processes.
Kolben
M
M
Frauenklinik und Poliklinik, Technischen Universität München, Klinikum rechts der Isar.
Lopens
A
A
Bläser
J
J
Huber
A
A
Frank
M
M
Wilhelm
O
O
Wilhelm
S
S
Schneider
K T
KT
Ulm
K
K
Tschesche
H
H
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000503:physiopathology; D017359:HELLP Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010447:Peptide Hydrolases / Q000097:blood*; D010920:Placenta / Q000201:enzymology*; D010929:Placentation / Q000502:physiology; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D012016:Reference Values; D014020:Tissue Extracts / Q000378:metabolism*; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014662:Vasoconstrictor Agents / Q000097:blood*; D014665:Vasodilator Agents / Q000097:blood*
D014020:Tissue Extracts; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D010447:Peptide Hydrolases
Konzentrationsmessungen verschiedener Proteolyse- und Gefässfaktoren im Plasma und Plazentaextrakt bei Schwangeren mit HELLP-Syndrom, Prä-/Eklampsie und hoch-pathologischen Dopplerflussbefunden.