title: New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.
abstract: Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.
authors.affiliation: Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Silva
authors.forename: M A
authors.initials: MA
authors.lastname: Schleupner
authors.forename: C O
authors.initials: CO
authors.lastname: Tacket
authors.forename: T S
authors.initials: TS
authors.lastname: Steiner
authors.forename: J B
authors.initials: JB
authors.lastname: Kaper
authors.forename: R
authors.initials: R
authors.lastname: Edelman
authors.forename: R
authors.initials: R
authors.lastname: Guerrant
mesh_terms: D022121:Cholera Vaccines / Q000009:adverse effects*; D003967:Diarrhea / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007781:Lactoferrin / Q000032:analysis; D009504:Neutrophils / Q000502:physiology; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014734:Vibrio cholerae / Q000472:pathogenicity*
chemical_list: D022121:Cholera Vaccines; D014613:Vaccines, Attenuated; D007781:Lactoferrin