title: Alpha-fetoprotein-mediated targeting of anti-cancer drugs to tumor cells in vitro.
abstract: An oncofetal protein, human alpha-fetoprotein, was selected as a vector molecule for targeted delivery of antitumor substances. Conjugates of alpha-fetoprotein with doxorubicin, daunomycin, calichemicin, carboxyphosphamide, bleomycetin, chlorbutin, cis-platinum, methotrexate were synthesized. All conjugates displayed a highly selective antitumor cytotoxic activity towards human cell cultures. The optimal alpha-fetoprotein:cytotoxic compound ratio was shown to be 1:3 - 1:5. The results obtained serve as a basis for creating antitumor preparations of a new generation, which are highly selective to tumor cells owing to receptor-mediated endocytosis.
authors.affiliation: Moscow's Research Institute of Medical Ecology, Russia.
authors.forename: S E
authors.initials: SE
authors.lastname: Severin
authors.lastname: Moskaleva EYu
authors.forename: I I
authors.initials: II
authors.lastname: Shmyrev
authors.forename: G A
authors.initials: GA
authors.lastname: Posypanova
authors.lastname: Belousova YuV
authors.forename: V K
authors.initials: VK
authors.lastname: Sologub
authors.lastname: Luzhkov YuM
authors.forename: R
authors.initials: R
authors.lastname: Nakachian
authors.forename: J
authors.initials: J
authors.lastname: Andreani
authors.forename: E S
authors.initials: ES
authors.lastname: Severin
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D016923:Cell Death / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D014407:Tumor Cells, Cultured; D000509:alpha-Fetoproteins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000509:alpha-Fetoproteins