title: [Toxoplasmosis-chorioretinitis: clinical course and treatment of seven patients].
abstract: Toxoplasmosis is a major and preventable cause of severe visual loss and blindness in young people. Ocular toxoplasmosis is the leading cause of posterior uveitis and in most cases it represents a late manifestation of a congenital infection. The clinical picture and anti-Toxoplasma therapy of seven patients referred to the Department of Infectious Diseases, Hvidovre Hospital is described. All patients had clinical ocular toxoplasmosis at initial examination with unilateral focal necrotizing retinitis associated with typical old, pigmented scars. All patients had anti-toxoplasmosis IgG antibodies. After anti-Toxoplasma therapy with sulfadiazine, pyrimethamine and corticosteroid the ocular lesions were healed to atrophic scars and the inflammatory activity disappeared. We conclude that when the clinical picture is compatible with toxoplasmosis, antibodies to Toxoplasma gondii are demonstrated and there is no other diagnosis, anti-Toxoplasma treatment should be considered. It is important to inform pregnant women about prophylactic measures, and to perform a serological screening of newborns, since treatment of congenital toxoplasmosis from birth improves the prognosis.
authors.affiliation: Hvidovre Hospital, infektionsmedicinsk afdeling.
authors.forename: A M
authors.initials: AM
authors.lastname: Lebech
authors.forename: M
authors.initials: M
authors.lastname: Lebech
authors.forename: K K
authors.initials: KK
authors.lastname: Børme
authors.forename: L R
authors.initials: LR
authors.lastname: Mathiesen
mesh_terms: D000293:Adolescent; D000328:Adult; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage; D000962:Antimalarials / Q000008:administration & dosage; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D002981:Clindamycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011739:Pyrimethamine / Q000008:administration & dosage; D012189:Retrospective Studies; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis / Q000188:drug therapy*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D000962:Antimalarials; D002981:Clindamycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D011739:Pyrimethamine
vernacular_title: Toksoplasmose-chorioretinitis: klinisk forløb og behandling af syv patienter.