[Comparison of the effect of HI-6 oxime and its derivatives in combination with benactyzine on cholinergic and stress effects of soman in rats].
In male rat experiments, the therapeutic effect of oxime HI-6 and its derivatives (HI-6 ester and amide) in combination with benactyzine on the cholinergic and stressogenic effects of a sublethal dose of soman was compared. Cholinergic effects were investigated by monitoring the changes in the activity of cholinesterases in the whole blood, brain and diaphragm, stressogenic effects by monitoring the changes in the level of corticosterone in the plasma and the activity of tyrosine aminotransferase in the liver. The monitoring of the changes in the selected parameters of cholinergic and stressogenic effects of soman has demonstrated that neither of the derivatives of oxime HI-6 under study achieves its therapeutic effect and thus seems to be a suitable substitute of oxime HI-6 for the therapy of acute intoxications with the organophosphate soman, which are difficult to treat.
Kassa
J
J
Vojenská lékarská akademie JEP, Hradec Králové.
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D001535:Benactyzine / Q000008:administration & dosage / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D002802:Cholinesterases / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004359:Drug Therapy, Combination; D008297:Male; D010091:Oximes; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000506:poisoning*; D014444:Tyrosine Transaminase / Q000378:metabolism
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D010091:Oximes; D010276:Parasympatholytics; D011726:Pyridinium Compounds; D001535:Benactyzine; D012999:Soman; D014444:Tyrosine Transaminase; D002802:Cholinesterases; C022870:asoxime chloride; D003345:Corticosterone
Srovnání vlivu oximu HI-6 a jeho derivátů v kombinaci s benaktyzinem na cholinergní a stresogenní ucinky somanu u potkana.