title: Intracranial pressure and hemodynamic effects of remifentanil versus alfentanil in patients undergoing supratentorial craniotomy.
abstract: Remifentanil hydrochloride is an ultra-short-acting esterase metabolized mu-opioid receptor agonist. The purpose of this study was to provide preliminary information regarding the effects of this drug on intracranial pressure (ICP) and mean arterial pressure (MAP) in patients scheduled for craniotomy. Twenty-six patients undergoing excision of supratentorial space-occupying lesions were anesthetized with 0.3-0.8 vol% isoflurane in a 2:1 mixture of nitrous oxide:oxygen. Ventilation was adjusted to provide a Paco2 of < 30 mm Hg. After the first burr hole was drilled, patients (n = 5-6 per group) were administered an intravenous infusion of study drug (placebo, remifentanil 0.5 micrograms/kg or 1.0 micrograms/kg, or alfentanil 10 micrograms/kg or 20 micrograms/kg) over 1 min. Epidural ICP and MAP values were recorded at baseline, at completion of infusion, and every minute for the next 10 min. Blood study drug concentrations were measured immediately after completion of infusion. Neither opioid caused a significant increase in ICP. Both drugs were associated with a dose-dependent decrease in MAP. Remifentanil was 31 times more potent than alfentanil for effects on MAP. We conclude that remifentanil produces similar cerebral perfusion pressure effects as does alfentanil.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Warner
authors.forename: B J
authors.initials: BJ
authors.lastname: Hindman
authors.forename: M M
authors.initials: MM
authors.lastname: Todd
authors.forename: P D
authors.initials: PD
authors.lastname: Sawin
authors.forename: J
authors.initials: J
authors.lastname: Kirchner
authors.forename: C L
authors.initials: CL
authors.lastname: Roland
authors.forename: B D
authors.initials: BD
authors.lastname: Jamerson
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects*; D002526:Cerebellar Diseases / Q000601:surgery; D003399:Craniotomy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010919:Placebos; D011957:Receptors, Opioid / Q000819:agonists; D000077208:Remifentanil
chemical_list: D000701:Analgesics, Opioid; D010880:Piperidines; D010919:Placebos; D011957:Receptors, Opioid; D015760:Alfentanil; D000077208:Remifentanil