title: Effect of vitamin K2 on experimental calcinosis induced by vitamin D2 in rat soft tissue.
abstract: The effect of vitamin K2 on calcium (Ca) and inorganic phosphorus (P) levels in the aorta and kidney obtained from experimental calcinosis induced by vitamin D2(2.5 x 10(5) I.U./ kg b.w.) of male rats was investigated. A high dose of vitamin K2 (100 mg/kg b.w.) inhibited the increase in the aortic Ca and P or in the renal Ca and P induced by vitamin D2, and a low dose of vitamin K2 (10 mg/kg b.w.) showed the same tendency, but the degree of the efficacy was small. It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. Therefore, a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of arteriosclerosis with calcification.
authors.affiliation: Dept. of Clinical Chemistry, Hoshi College of Pharmacy, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Seyama
authors.forename: M
authors.initials: M
authors.lastname: Horiuch
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kanke
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism; D002114:Calcinosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004872:Ergocalciferols; D007668:Kidney / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014812:Vitamin K / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D004872:Ergocalciferols; D014812:Vitamin K; D010758:Phosphorus; D002118:Calcium