Dynamin and receptor-mediated endocytosis.
The internalization of receptor-bound ligands involves concentration of cell surface receptors in specialized areas of the plasma membrane and subsequent formation of clathrin-coated vesicles. The complex process of invagination, constriction and budding of clathrin-coated vesicles employs the coordinated actions of several proteins. This review is focused on the GTPase dynamin, which plays a key role in the constriction of coated pits.
Damke
H
H
Dept. of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
D000818:Animals; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D011956:Receptors, Cell Surface / Q000502:physiology*
D011956:Receptors, Cell Surface; D020558:GTP Phosphohydrolases; D034281:Dynamins