title: Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data.
abstract: We undertook a phase I-II trail of loco-regional mitoxantrone in 12 patients affected by malignant gliomas. Mitoxantrone was delivered at tumor recurrence by Ommaya reservoir, with 2 cycles and a 1 month interval between each cycle, in conjunction with systemic chemotherapy (8 pts) or not (4 pts). Treatment tolerability was good, and 9 of the patients showed either response or stable disease at the end of the treatment schedule. Regardless of associated chemotherapy, time to further tumor progression was at 6 months. A combination of early systemic and loco-regional chemotherapy with surgery and radiotherapy seems worth while pursuing in the therapeutic approach to malignant gliomas.
authors.affiliation: Department of Neurology, Istituto Nazionale Neurologico Carlo Besta, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Boiardi
authors.forename: A
authors.initials: A
authors.lastname: Salmaggi
authors.forename: A
authors.initials: A
authors.lastname: Pozzi
authors.forename: G
authors.initials: G
authors.lastname: Broggi
authors.forename: A
authors.initials: A
authors.lastname: Silvani
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation*; D004569:Electroencephalography; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D008942:Mitoxantrone