Polytolypin, a new antifungal triterpenoid from the coprophilous fungus Polytolypa hystricis.
Polytolypin [1], a new pentacyclic triterpenoid exhibiting antifungal and antibiotic activity, has been isolated from cultures of Polytolypa hystricis (JS189), a fungal colonist of porcupine dung. Two known compounds [2 and 3] were also isolated. Polytolypin was obtained by chromatographic fractionation of the EtOAc extract of P. hystricis liquid cultures, and the structure was assigned on the basis of 2D nmr and hrms data.
Gamble
W R
WR
Department of Chemistry, University of Iowa, Iowa City 52242, USA.
Gloer
J B
JB
Scott
J A
JA
Malloch
D
D
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003998:Dicarboxylic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D005243:Feces / Q000382:microbiology; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D012377:Rodentia / Q000382:microbiology*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D003998:Dicarboxylic Acids; D014315:Triterpenes; C100484:polytolypin