The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3.
We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.
Sieg
S
S
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4943, USA.
King
C
C
Huang
Y
Y
Kaplan
D
D
D000328:Adult; D000818:Animals; D017209:Apoptosis; D017252:CD3 Complex / Q000276:immunology; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D018108:Respirovirus / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D017252:CD3 Complex; D016753:Interleukin-10