Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection.
Reactivation of EBV infection is common in immunocompromised individuals. We determined specific antibodies to EBV-encoded nuclear antigens (EBNA)1 and 2 in 102 sera of HIV-infected individuals. Anti-EBNA1/anti-EBNA2 ratio (E1/E2) is less than 1 in chronic infection and exceeds 1 in healthy EBV-positive carriers. 52% of cases had E1/E2 < 1. E1/E2 decreased remarkably during the progression of HIV infection. Detectable HIV-Antigen, decline of CD4+ cell count and CD4+/CD8+ ratio were correlated with an increasing prevalence of E1/E2 below 1. We conclude that determination of E1/E2 is useful in immunocompromised patients.
Winkelspecht
B
B
Abteilung Innere Medizin IV, Universitätskliniken des Saarlandes, Homburg/Saar, Federal Republic of Germany.
Grässer
F
F
Pees
H W
HW
Mueller-Lantzsch
N
N
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology*; D016516:CD4-CD8 Ratio; D004268:DNA-Binding Proteins / Q000276:immunology*; D019309:Epstein-Barr Virus Nuclear Antigens; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008875:Middle Aged
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens