title: [Amines and pteridines].
abstract: Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation, and have been established as tumors markers. We and other workers have confirmed that N1-acetylspermidine in tumor tissues, spermidine and spermine in erythrocytes, and N1,N12-diacetylspermine in urine might be the most sensitive indicators for various forms of tumors. Neopterin is a marker of cell-mediated immunostimulation, and may be a helpful marker in monitoring cancer patients. HPLC and immunological assays of neopterin, biopterin, and N2-(3-aminopropyl)biopterin(oncopterin) in urine might be useful in the clinical study of pteridines, as cancer markers. Serum 5-S-cysteinyldopa level is a useful and specific biochemical marker for malignant melanoma.
authors.affiliation: Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University.
authors.forename: K
authors.initials: K
authors.lastname: Shimpo
authors.forename: T
authors.initials: T
authors.lastname: Chihara
authors.forename: M
authors.initials: M
authors.lastname: Hibiya
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Nagatsu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001708:Biopterins / Q000031:analogs & derivatives* / Q000032:analysis; D003548:Cysteinyldopa / Q000032:analysis; D006801:Humans; D008545:Melanoma / Q000175:diagnosis; D009369:Neoplasms / Q000175:diagnosis*; D019798:Neopterin; D011073:Polyamines / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D011073:Polyamines; D003548:Cysteinyldopa; D001708:Biopterins; D019798:Neopterin