title: A new approach for creating double-stranded DNA biosensors.
abstract: The principle of 'sandwich'-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was approximately 10-(14) M.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Skuridin
authors.forename: Y M
authors.initials: YM
authors.lastname: Yevdokimov
authors.forename: V S
authors.initials: VS
authors.lastname: Efimov
authors.forename: J M
authors.initials: JM
authors.lastname: Hall
authors.forename: A P
authors.initials: AP
authors.lastname: Turner
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis*; D008297:Male
chemical_list: D004247:DNA