[Digoxin-like immunoreactive factors. Review of the literature].
It is confirmed by several studies that in normal subjects a substance recognized by antibodies anti digoxin exists. Such a substance can be found at increased concentration in pregnant women, neonates, in liver or kidney diseases. A limited increase in concentration has been also registered in patients with essential hypertension and in normotensive patients with a family history of hypertension. Serum or urines rich in such a substance show an increased capacity of inhibiting in vitro the sodium-potassium pump and therefore in reducing also in vivo the capacity of reabsorption of sodium and with it, of water. The investigators interest for this substance has two main reasons: 1) the interference that such a substance has in dosages of digitalis in therapeutic monitorizing; 2) the possibility that such a substance has an important physiological role in hydroelectrolytic metabolism.
Ozzola
G
G
Laboratorio Analisi, Ospedale Civile di Bibbiena.
Boncompagni
L
L
Galastri
G
G
Liberatori
E
E
Marri
M
M
Mazzei
V
V
Patrizi
L
L
Parca
G
G
Piccini
L
L
Biagi
P
P
D000328:Adult; D002298:Cardenolides; D004077:Digoxin / Q000276:immunology*; D004791:Enzyme Inhibitors / Q000276:immunology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000276:immunology; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology; D008297:Male; D012503:Saponins / Q000276:immunology*; D012737:Sex Factors
D002298:Cardenolides; D004791:Enzyme Inhibitors; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin
Digoxin-like immunoreactive factor. Revisione della letteratura.