Disposition of remoxipride in Chinese schizophrenic patients.
The disposition of remoxipride was evaluated in 13 male chronic schizophrenic patients. A single 150 mg dose of remoxipride was administered and blood sampling performed over the following 48 hours. The mean (SD) oral clearance and half-life of remoxipride were 74.46 (25.9) ml/min and 5.46 (0.87) hours, respectively. The mean (SD) AUC for remoxipride was 25,320 (9,820) ng.h/ml. A wide interpatient variability was observed. Compared to Caucasian studies there were no significant differences in the disposition of remoxipride.
Lin
S K
SK
Taipei City Psychiatric Center, Taiwan, Republic of China.
Chang
W H
WH
Chien
C P
CP
Lam
Y W
YW
Jann
M W
MW
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002681:China; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D017330:Remoxipride / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000208:ethnology / Q000378:metabolism*
D014150:Antipsychotic Agents; D017330:Remoxipride