title: Effects on pulmonary function of two regimens of chemotherapy for AIDS related Kaposi's sarcoma.
abstract: We retrospectively analysed serial pulmonary function tests in 14 HIV infected patients receiving either bleomycin and vincristine or liposomal doxorubicin therapy (Doxil) for AIDS related Kaposi's sarcoma. There was a significant reduction in the carbon monoxide transfer coefficient in bleomycin treated patients compared with patients treated with Doxil. No other significant changes in pulmonary function, including the carbon monoxide diffusing capacity, were observed. These preliminary findings suggest that HIV infected patients with Kaposi's sarcoma, who are receiving bleomycin, may be at risk of accelerated pulmonary dysfunction. A larger prospective study should be performed to enable further investigation.
authors.affiliation: Department of Medicine, University College London Medical School, Middlesex Hospital, London, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Denton
authors.forename: J K
authors.initials: JK
authors.lastname: Simpson
authors.forename: M
authors.initials: M
authors.lastname: Hallam
authors.forename: M F
authors.initials: MF
authors.lastname: Spittle
authors.forename: R F
authors.initials: RF
authors.lastname: Miller
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002248:Carbon Monoxide / Q000378:metabolism; D004317:Doxorubicin / Q000627:therapeutic use; D015658:HIV Infections; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D001761:Bleomycin; D014750:Vincristine; D002248:Carbon Monoxide; D004317:Doxorubicin