Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event.
Boland
M P
MP
Biochemistry Department, Trinity College Dublin, Ireland, UK.
Foster
S J
SJ
O'Neill
L A
LA
D002518:Ceramides / Q000494:pharmacology*; D004789:Enzyme Activation; D018922:HL-60 Cells; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D009025:Morpholines / Q000494:pharmacology; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D013107:Sphingolipids / Q000494:pharmacology; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
C095823:1-phenyl-2-palmitoylamino-3-morpholino-1-propanol; D002518:Ceramides; D007527:Isoenzymes; D009025:Morpholines; D016328:NF-kappa B; D013107:Sphingolipids; D014409:Tumor Necrosis Factor-alpha; D013108:Sphingomyelin Phosphodiesterase