Studies on the genotoxicity of tamoxifen citrate in mouse bone marrow cells.
The genotoxic effects of tamoxifen citrate, an anti-oestrogenic drug, were studied using mouse bone marrow chromosome aberration assay (CA) and micronucleus (MN) test. The dose and time yield effects of the drug were investigated after repeated administration of various doses of the drug for 10 days. The doses used were, 0.1, 0.2, 0.4 and 0.8 mg/kg/day. Bone marrow preparations were made at 24, 48, 72 and 96 h after the last administration. The anticancer drug cyclophosphamide (CP) at a dose of 100 mg/kg was used as positive control. A statistically significant chromosomal aberration and MN induced by tamoxifen revealed its clastogenic potency.
Vijayalaxmi
K K
KK
Department of Studies in Applied Zoology, Mangalore University, India.
Rai
S P
SP
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity; D003582:Cytogenetics; D004965:Estrogen Antagonists / Q000633:toxicity*; D005821:Genetic Techniques; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D018709:Statistics, Nonparametric; D013629:Tamoxifen / Q000633:toxicity*
D004965:Estrogen Antagonists; D009153:Mutagens; D013629:Tamoxifen; D003520:Cyclophosphamide