Carbohydrate-protein interactions in vascular biology.
Carbohydrate-protein interactions participate in a wide variety of biological and pathological events. In recent years, particular attention has been paid to the carbohydrate-protein interactions that occur in vascular biology. Sialylated oligosaccharides are ligands of a structurally diverse group of proteins that include the selectins and members of the immunoglobulin superfamily. Various glycosaminoglycans can be recognized by an overlapping set of proteins that include two of the selectins and CD44. Emerging knowledge of carbohydrate-protein interactions in human pathophysiology are discussed.
Nelson
R M
RM
Amgen Boulder, Colorado 80301-2546, USA.
Venot
A
A
Bevilacqua
M P
MP
Linhardt
R J
RJ
Stamenkovic
I
I
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D001808:Blood Vessels / Q000502:physiology*; D002236:Carbohydrate Conformation; D050260:Carbohydrate Metabolism; D002240:Carbohydrate Sequence; D015815:Cell Adhesion Molecules; D006023:Glycoproteins / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D037102:Lectins / Q000378:metabolism*; D008322:Mammals; D008562:Membrane Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D011506:Proteins / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism; D019087:Selectins / Q000378:metabolism*; D063267:Sialic Acid Binding Ig-like Lectin 1; D051918:Sialic Acid Binding Ig-like Lectin 2
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate; D006820:Hyaluronic Acid; D037102:Lectins; D008562:Membrane Glycoproteins; D011506:Proteins; D011971:Receptors, Immunologic; D019087:Selectins; D063267:Sialic Acid Binding Ig-like Lectin 1; D051918:Sialic Acid Binding Ig-like Lectin 2; C497867:CD22 protein, human; C571166:SIGLEC1 protein, human