Antral axial forces postprandially and after erythromycin in organic and functional dysmotilities.
Our aims were to measure antral axial forces in patients with suspected upper gut dysmotilities and to compare the number of antral contractions detected by an axial force catheter and by manometric sensors in the distal antrum and pylorus. Fifteen patients (2 men, 13 women; mean age 42 years) underwent studies for 3 hr fasting, 2 hr postprandially, and up to 60 min after intravenous erythromycin (3mg/kg). Seven patients had gastroparesis or chronic intestinal pseudoobstruction, five functional disease, and three subacute obstruction. Postprandially, the number of peaks detected by the two methods was not significantly different; however, after erythromycin, the axial catheter detected more contractions (P = 0.02). Erythromycin significantly increased the number of postprandial axial forces (from 1.2 +/- 0.3/min to 2.5 +/- 0.3/min, P < or = 0.01) in the whole group and in the organic dysmotility group (P = 0.01). Erythromycin significantly increases the number of axial forces in functional and organic upper gut dysmotilities, but the axial force catheter is not advantageous over manometry for postprandial measurements of antral motility.
Surrenti
E
E
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
Camilleri
M
M
Kammer
P P
PP
Prather
C M
CM
Schei
A J
AJ
Hanson
R B
RB
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002404:Catheterization / Q000295:instrumentation; D004435:Eating; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D005502:Food; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology*; D018589:Gastroparesis / Q000503:physiopathology; D006801:Humans; D007415:Intestinal Obstruction / Q000503:physiopathology; D007418:Intestinal Pseudo-Obstruction / Q000503:physiopathology; D008297:Male; D008365:Manometry; D011706:Pyloric Antrum / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D004917:Erythromycin