Dental anxiety and the absorption of orally administered erythromycin stearate.
Erythromycin stearate is an acid labile antibiotic, therefore fear and apprehension, which are known to affect gastric motility, may produce erratic absorption resulting in lower serum levels. The mean (SD) serum erythromycin concentration 75 minutes after a 1.5 gm oral dose of erythromycin stearate to 45 patients was 8.7 (4.8) mg/L and ranged widely from 0.4 to 20.5 mg/L. The serum concentration of erythromycin was below therapeutic levels (1.0 mg/L) in two patients. No significant association was found between anxiety and serum levels of erythromycin when age, gender, and gastric distress were taken into account. It is concluded that dental anxiety may indirectly influence the uptake of oral erythromycin stearate; but this relationship is complex, and there is no evidence from this study that increased dental anxiety decreases the uptake of the drug.
Coulter
W A
WA
Department of Restorative Dentistry, Queen's University of Belfast, Northern Ireland.
McGimpsey
J G
JG
Coffey
A
A
Strawbridge
J
J
Linden
G J
GJ
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D001682:Biological Availability; D016854:Dental Anxiety / Q000503:physiopathology*; D017742:Dental Care for Chronically Ill / Q000523:psychology; D003777:Dental Prophylaxis / Q000523:psychology; D004697:Endocarditis, Bacterial / Q000517:prevention & control; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D008347:Manifest Anxiety Scale; D008875:Middle Aged; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014081:Tooth Extraction / Q000523:psychology
D000900:Anti-Bacterial Agents; D004917:Erythromycin; C011462:erythromycin stearate