title: Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
abstract: The sulfated flavonoids in Polygonum hydropiper showed potent inhibiton against lens aldose reductase. Among these flavonoids isorhamnetin 3,7-disulfate (5) was most potent. Kinetic analysis showed that 5 exhibited noncompetitive inhibition against both dl-glyceraldehyde and NADPH.
authors.affiliation: Faculty of Engineering, Fukuyama University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Haraguchi
authors.forename: I
authors.initials: I
authors.lastname: Ohmi
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Toihara
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: N
authors.initials: N
authors.lastname: Okamura
authors.forename: A
authors.initials: A
authors.lastname: Yagi
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology; D007908:Lens, Crystalline / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D013552:Swine
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D000449:Aldehyde Reductase; D009247:NADH, NADPH Oxidoreductases