Interleukin-10 protects neonatal mice from lethal group B streptococcal infection.
We investigated the role of interleukin-10 (IL-10) in a neonatal mouse model of lethal group B streptococci (GBS) sepsis. Plasma IL-10 levels significantly increased at 24 and 48 h after GBS inoculation. Neutralization of IL-10 with specific antibodies had no effect on lethality. Administration of recombinant IL-10 at 20 or 4 h before challenge, but not at later times, resulted in decreased tumor necrosis factor alpha levels and improved survival. IL-10 could be potentially useful for the treatment of GBS sepsis.
Cusumano
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V
Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Universita degli Studi di Messina, Italy.
Genovese
F
F
Mancuso
G
G
Carbone
M
M
Fera
M T
MT
Teti
G
G
D000818:Animals; D000831:Animals, Newborn; D016753:Interleukin-10 / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D011994:Recombinant Proteins / Q000494:pharmacology; D013290:Streptococcal Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D013292:Streptococcus agalactiae / Q000472:pathogenicity; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10