title: [Clinical studies of fluconazole in patients with deep-seated fungal infection in intravenous hyperalimentation (IVH)].
abstract: Clinical efficacy of fluconazole on fungal infections was evaluated. Fluconazole was administrated orally or intravenously to 16 cases with fungal infections (chronic renal failure 4, congestive heart failure 2, cerebral infarction 2, etc). All cases were suspected of mycosis. The details of those administrated were 16 cases of pneumonia 3 cases, fungemia 9 cases (suspected 7 cases) and urinary tract infection 3 cases. Clinical efficacy rate was 71.4%. Side-effects were observed in only 1 case, and this consisted of transient increase of leukocytes and thrombocytes. Fluconazole is considered to be a potent, safe antifungal agent for the treatment of suspected fungal infection during intravenous hyperalimentation.
authors.affiliation: Second Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: I
authors.initials: I
authors.lastname: Tatara
authors.forename: K
authors.initials: K
authors.lastname: Kono
authors.forename: K
authors.initials: K
authors.lastname: Arakawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole