A randomized trial of pefloxacin plus klindamicin and cefoxitin in hepatobiliary and pancreatic surgery.
OBJECTIVE
The efficacy and safety of pefloxacin plus klindamicin with cefoxitin were studied in patients undergoing hepatobiliary or pancreatic surgery.


METHODS
Seventy-five patients with biliary tract, hepatic, or pancreatic pathology were randomly allocated in a prospective open study to receive a combination of either i.v or oral pefloxacin (800mg per day) plus klindamicin (2,400mg per day) or an i.v. cefoxitin (4,000mg per day).


RESULTS
Twenty patients had to be withdrawn from the trial because of negative baseline culture or because of isolation of bacteria resistant to the study drugs. In the remaining fifty-five patients, the clinical cure rates were excellent in more than ninety five percent and similar for both groups, the bacteriological success rates were 100% in the pefloxacin plus klindamicin group and 89.1% in the cefoxitin group. No patients were withdrawn from the study because of side effects.


CONCLUSIONS
In our study we have shown the excellent results of the antibacterial therapy with pefloxacin and klindamicin of the patients who underwent complicated hepatobiliary and pancreatic surgery.
Fried
M
M
First Surgical Department, Charles University Hospital, Prague, Czech Republic.
Peskova
M
M
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D001662:Biliary Tract Surgical Procedures; D002440:Cefoxitin / Q000008:administration & dosage*; D002513:Cephamycins / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000601:surgery*; D015366:Pefloxacin / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy
D000890:Anti-Infective Agents; D002513:Cephamycins; D015366:Pefloxacin; D002981:Clindamycin; D002440:Cefoxitin