title: Bacterial endocarditis revealed by infectious discitis.
abstract: A study of 30 patients admitted for infectious discitis identified four cases with concomitant bacterial endocarditis. All four patients were male and had concomitant streptococcal septicemia. Two patients had known aortic valve disease. The vertebral infection was located to the thoracic or lumbar spine. Ultrasonography disclosed aortic lesions in all four patients and mitral lesions in two. Management consisted of intravenous antimicrobial therapy for four weeks followed by a three-month course of oral antimicrobial therapy. The outcome of the discitis was favorable within the usual period of time. However, the endocardial lesions continued to progress, and three patients rapidly required valve replacement. Analysis of available data in the 30 patients with discitis showed that half the patients with streptococcal discitis also had bacterial endocarditis and that the latter condition developed in all the patients with streptococcal discitis and a history of valve disease. A number of risk factors were identified. An echocardiogram should be done routinely in patients with infectious discitis and risk factors for bacterial endocarditis.
authors.affiliation: Rheumatology Department, Teaching Hospital, Angers, France.
authors.forename: C
authors.initials: C
authors.lastname: Pascaretti
authors.forename: E
authors.initials: E
authors.lastname: Legrand
authors.forename: J
authors.initials: J
authors.lastname: Laporte
authors.forename: P
authors.initials: P
authors.lastname: Fromont
authors.forename: C
authors.initials: C
authors.lastname: Masson
authors.forename: C
authors.initials: C
authors.lastname: Brégeon
authors.forename: M
authors.initials: M
authors.lastname: Audran
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015299:Discitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013904:Thoracic Vertebrae; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents