[The effect of the dispersity of tegalid on its bioavailability].
The impact of the new helminthicide Tegalide, a dibromobenzamide derivative, on its pharmacology was investigated. The agent given as a fine-dispersed form was found to be more intensively absorbed by the body and to be in animals' blood for a longer period of time (MRT fine-dispersed and MVR coarse-dispersed were 88.5 and 50.4 hours, respectively). As the fine-dispersed fraction of Tegalide increased, its bioavailability showed an equivalent increase.
Lopatina
N B
NB
Lebedeva
M N
MN
Mikhaĭlitsyn
F S
FS
Khalikov
S S
SS
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D001549:Benzamides / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008297:Male; D010316:Particle Size; D011817:Rabbits; D013997:Time Factors
D000871:Anthelmintics; D001549:Benzamides; C048082:tegalide
Vliianie dispersnosti tegalila na ego biodostupnost'.