title: The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3.
abstract: We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4943, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sieg
authors.forename: C
authors.initials: C
authors.lastname: King
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Kaplan
mesh_terms: D000328:Adult; D000818:Animals; D017209:Apoptosis; D017252:CD3 Complex / Q000276:immunology; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D018108:Respirovirus / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D017252:CD3 Complex; D016753:Interleukin-10