Cytomegalovirus antibody status and renal transplantation: 1987-1994.
We examined graft and patient survival rates of 47,146 patients in the United Network for Organ Sharing registry following transplants between donors and recipients who were cytomegalovirus (CMV) antibody negative and positive. CMV positivity increased with age to about 80% in patients over 60. Seropositivity was seen in 80% of Asians, 71% of African Americans, and 56% of Caucasians. In all age groups, females had a slightly higher incidence of positivity than males. Transplants involving CMV-positive donors resulted in lower graft survival rates than those with CMV-negative donors. This occurred regardless of whether the recipient was CMV negative or positive. The greatest effect was on patient survival rate, which, in turn, adversely affected graft survival rate. The CMV-positive-donor effect was primarily noted in (1) Caucasian recipients, (2) patients with HLA-A,B,DR mismatches, and (3) patients older than 15 years of age. In contrast, CMV-positive donors were not a risk factor for African American and Hispanic patients, CMV-positive Asian patients, patients younger than 16 years of age, and patients with no HLA-A,B,DR antigen mismatches. In conclusion, a kidney from a CMV-positive donor is a risk factor for certain patients and currently yields about a 4% overall lower graft survival rate at 3 years than a kidney from a CMV-negative donor.
Hirata
M
M
Department of Surgery, UCLA Medical School, Los Angeles, California 90095-1652, USA.
Terasaki
P I
PI
Cho
Y W
YW
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002102:Cadaver; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000517:prevention & control; D005260:Female; D006085:Graft Survival; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D044469:Racial Groups; D016019:Survival Analysis; D014019:Tissue Donors; D014481:United States