title: Changes in frequency of orthostatic hypotension in elderly hypertensive patients under medications.
abstract: To evaluate changes in frequency of orthostatic blood pressure (BP) reduction (orthostatic hypotension; OH) in elderly hypertensive patients (HT) before and after treatment for hypertension, we measured BP after supine for 10 min and standing position for 2 min, before and after treatment for 2 years by five kinds of antihypertensive drugs in 50 elderly normotensive subjects (NT) and each of 50 HT in double-blind study. Orthostatic hypotension was defined as 10% or more decline of supine mean BP, and the frequency of OH was in 27% of HT following BP reduction by any kinds of antihypertensive drugs. In conclusion, the reducing or normalized BP by treatment for hypertension in elderly HT decreases the prevalence of orthostatic hypotension.
authors.affiliation: Department of Geriatric Medicine, Osaka University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Masuo
authors.forename: H
authors.initials: H
authors.lastname: Mikami
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
authors.forename: M L
authors.initials: ML
authors.lastname: Tuck
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D007024:Hypotension, Orthostatic / Q000097:blood / Q000503:physiopathology*; D007564:Japan; D009638:Norepinephrine / Q000097:blood; D011187:Posture; D015995:Prevalence
chemical_list: D000959:Antihypertensive Agents; D009638:Norepinephrine