title: [Late radiation-induced injuries: breast carcinoma in post-actinic ulceration of the thoracic-breast region with infected osteoradionecrosis. A case report].
abstract: Severe skin reactions are commonly observed after breast irradiation. Chronic ulcerations, soft tissue damage and osteonecrosis are well-known though relatively rare long-term radiation-induced injuries. The ever-present possibility of recurrence or persistence of the primary malignant neoplasm within the irradiated tissue must be always suspected and adequately established by multiple biopsies before planning an eventual resective and or reconstructive strategy. In the present report a neoplastic recurrence arised from an extensive radiation-induced ulceration along the parasternal area with chest wall osteonecrosis complicated by infection in a 42 y.o. woman, who had received postoperative roentgen therapy a long time before for breast carcinoma and thyroid cancer, is described. Radiation-induced injuries and therapeutical options are discussed in relation to the site of the lesion and to the complexity of the single case. In conclusion, when recurrent malignancy is present, although the long-term prognosis may be poor, the quality of life of many patients undoubtedly may be improved by a multidisciplinary approach involving oncologysts, as well as general, thoracic and plastic surgeons.
authors.affiliation: Prima Divisione Chirurgia Generale Pizzamiglio, Ospedale Niguarda Ca' Granda, Milano.
authors.forename: I
authors.initials: I
authors.lastname: Sironi
authors.forename: A M
authors.initials: AM
authors.lastname: Crespi
authors.forename: E
authors.initials: E
authors.lastname: Magnoni
authors.forename: M
authors.initials: M
authors.lastname: Mattioli
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Vai
authors.forename: A
authors.initials: A
authors.lastname: Russo
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D001941:Breast Diseases / Q000209:etiology; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D010025:Osteoradionecrosis / Q000209:etiology*; D011832:Radiation Injuries; D011867:Radioisotope Teletherapy; D011878:Radiotherapy / Q000009:adverse effects*; D013896:Thoracic Diseases / Q000209:etiology; D013964:Thyroid Neoplasms / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy; D013997:Time Factors; D014456:Ulcer / Q000209:etiology
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Danno tardivo da radiazioni: carcinoma della mammella su ulcera post-attinica della regione toraco-mammaria con osteoradionecrosi contaminata. Descrizione di un caso.