Liver dysfunction in the early post-bone marrow transplant period.
In the paper hepatic dysfunctions occurring in more than 80% recipients of HLA-matched bone marrow transplants (BMT) in the early post-transplant period (< 100 days) is described. They involve veno-occlusive disease (VOD) and acute graft-versus-host disease (aGVHD). Liver dysfunctions can be also caused by unfavourable effects of drugs and by infections. Etiopathogenesis, clinical and laboratory findings, diagnosis, therapy and prophylaxis of the dysfunctions in question is being described in detail.
Storek
J
J
Fred Hutschinson Cancer Research Center, University of Washington School of Medicine, Seattle, USA.
D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000209:etiology; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology; D006525:Hepatitis, Viral, Human / Q000209:etiology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008107:Liver Diseases / Q000209:etiology* / Q000503:physiopathology; D009894:Opportunistic Infections; D013997:Time Factors