Topical ibuprofen for skin analgesia prior to venepuncture.
The analgesic effect of topical ibuprofen was investigated in ten volunteers. There were no significant differences in visual analogue scale pain scores for pinprick after 15 and 60 min of application of ibuprofen, placebo and EMLA cream. Comparison of visual analogue scale scores for venous cannulation after similar durations of ibuprofen and EMLA creams found significantly (p < 0.014) lower scores for EMLA at 60 min. We do not consider ibuprofen cream to be clinically useful for venous cannulation.
Smith
A J
AJ
Department of Anaesthesia, University Hospital of Wales, Cardiff.
Eggers
K A
KA
Stacey
M R
MR
D000287:Administration, Topical; D000698:Analgesia / Q000379:methods*; D000779:Anesthetics, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002406:Catheterization, Peripheral / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D008012:Lidocaine / Q000627:therapeutic use; D000077442:Lidocaine, Prilocaine Drug Combination; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D018962:Phlebotomy / Q000009:adverse effects*; D011318:Prilocaine / Q000627:therapeutic use
D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine; D007052:Ibuprofen