Transcription factors responsive to cAMP.
In eukaryotes, transcriptional regulation upon stimulation of the adenylate cyclase signaling pathway is mediated by a family of cAMP-responsive nuclear factors. This family consists of a large number of members that may act as activators or repressors. These factors contain the basic domain/leucine zipper motifs and bind as dimers to cAMP-response elements (CRE). The function of CRE-binding proteins is modulated by phosphorylation by several kinases. The ICER (inducible cAMP early repressor) protein is the only inducible member of this family. The induction of this powerful repressor is likely to be important for the transient nature of cAMP-induced gene expression. CRE-binding proteins have been found to play an important role in the physiology of the pituitary gland, in regulating spermatogenesis, in the response to circadian rhythms, and in the molecular basis of memory.
Sassone-Corsi
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Institut de Génétique et de Biologie Moléculaire et Cellulaire, C.U. de Strasbourg, France.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000378:metabolism*; D051786:Cyclic AMP Response Element Modulator; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D051790:G-Box Binding Factors; D005786:Gene Expression Regulation; D005973:Glutamine; D006801:Humans; D007438:Introns; D016350:Leucine Zippers; D008297:Male; D008568:Memory; D008969:Molecular Sequence Data; D010902:Pituitary Gland / Q000502:physiology; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013091:Spermatogenesis; D014157:Transcription Factors / Q000096:biosynthesis / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D051790:G-Box Binding Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D005973:Glutamine; D051786:Cyclic AMP Response Element Modulator; D000242:Cyclic AMP