Fuel metabolism in deviant fetal growth in offspring of diabetic women.
Fetal growth and development from its very first stages of intrauterine life is significantly influenced by the metabolic environment in which the conceptus develops. Maternal disease states such as gestational diabetes and hypertensive pregnancy, representing maternal conditions involved in extremes of impaired fetal growth (macrosomia versus growth restriction), can serve as excellent examples of the various factors that are involved in intrauterine growth.
Hod
M
M
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah Tiqva, Israel.
Langer
O
O
D016640:Diabetes, Gestational / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D004734:Energy Metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000378:metabolism; D005320:Fetal Macrosomia / Q000209:etiology / Q000378:metabolism; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism; D011254:Pregnancy in Diabetics / Q000378:metabolism