Treatment of scleromyxedema with 2-chlorodeoxyadenosine.
Scleromyxedema is an unusual skin disease that is characterized by a proliferation of fibroblasts and an accumulation of mucin. Despite experience with multiple forms of therapy, no single agent has proved uniformly beneficial in this condition. We describe a patient with scleromyxedema who was treated successfully with 2-chlorodeoxyadenosine (2-CdA), a purine analog used mainly in the treatment of lymphoproliferative disorders.
Davis
L S
LS
Department of Medicine, Medical College of Georgia, Augusta 30904, USA.
Sanal
S
S
Sangueza
O P
OP
D017338:Cladribine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000473:pathology*
D007166:Immunosuppressive Agents; D017338:Cladribine