Bone mineral density of the spine using dual energy X-ray absorptiometry in patients with non-insulin-dependent diabetes mellitus.
To evaluate the influence of non-insulin-dependent diabetes mellitus (NIDDM) on bone mineral density (BMD), we measured BMD in 185 female patients with NIDDM using dual energy X-ray absorptiometry (DEXA). BMD was measured in lumbar vertebrae (L2-4). BMD is slightly higher in the diabetic patients compared with control subjects and bone loss related to menopause starts before the onset of menopause. The BMD of postmenopausal women showed a definite decrease with aging and there was abrupt bone loss after 55 years of age (p < 0.05). In relation to the duration of diabetes, the decrease of BMD for 15 years was 10.0%. BMD was negatively correlated with age, years since menopause (YSM), and disease duration (r = -0.584, r = -0.470, r = -0.186). These results suggest that age, YSM, and the duration of disease appear to be the risk factors for decreased BMD in the diabetic patients.
Kwon
D J
DJ
Department of Obstetrics and Gynecology, Catholic University Medical College, Uijeongbu Saint Mary's Hospital, Gyeonggi-do, Korea.
Kim
J H
JH
Chung
K W
KW
Kim
J H
JH
Lee
J W
JW
Kim
S P
SP
Lee
H Y
HY
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000375:Aging; D015519:Bone Density / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D007723:Korea; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000378:metabolism; D017698:Postmenopause; D012307:Risk Factors