The predicted amino acid sequence of the Salmonella typhimurium virulence gene mviAA(+) strongly indicates that MviA is a regulator protein of a previously unknown S. typhimurium response regulator family.
The Salmonella typhimurium virulence gene mviA+ has a predicted amino acid sequence with homology to the N-terminal 112-amino-acid sequence of response regulator proteins. A previously described mutant allele (mviA), which restores virulence to avirulent LT2 strains, was shown to contain a point mutation which would be predicted to cause a single amino acid change, V-102-->G (W. H. Benjamin, Jr., J. Yother, P. Hall, and D. E. Briles, J. Exp. Med. 1,74:1073-1083, 1991). A comparison of the nucleotide sequence of mviA+ with that of the Escherichia coli and Salmonella typhi genes revealed a high degree of conservation.
Benjamin
W H
WH
The Department of Pathology, The University of Alabama at Birmingham, 35294, USA.
Wu
X
X
Swords
W E
WE
D000483:Alleles; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry*; D001483:Base Sequence; D017124:Conserved Sequence; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009154:Mutation; D012486:Salmonella typhimurium / Q000737:chemistry / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence
D001426:Bacterial Proteins