[Nephrotoxicity evaluation of cytostatic agents in children with acute lymphoblastic leukemia].
Urinary excretion of the markers of tubular nephrotoxicity, total NAG and isoenzymes A and B and B-2-M, were evaluated in urine of 21 children with acute lymphoblastic leukaemia after the first injection of cytostatic administrated according to the BFM scheme: VCR + Rub, L-aspa, CY, Ara-C. Every administrated drug caused temporary elevation in urinary excretion of total NAG and isoenzyme B and B-2-M. GFR was unchanged. These results point to nephrotoxicity of cytostatics. Peak total NAG, isoenzyme B and B-2-M excretion was observed on the third day after L-aspa and Ara-C injection.
Tomaszewska
B
B
I Klinika Chorób Dzieci Akademii Medycznej w Białymstoku.
Zoch-Zwierz
W M
WM
D000118:Acetylglucosaminidase / Q000652:urine*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001215:Asparaginase / Q000008:administration & dosage; D015415:Biomarkers / Q000032:analysis; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D007527:Isoenzymes / Q000652:urine*; D007684:Kidney Tubules / Q000187:drug effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
D015415:Biomarkers; D007527:Isoenzymes; D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D000118:Acetylglucosaminidase; D001215:Asparaginase; D003630:Daunorubicin
Ocena nefrotoksyczności cytostatyków u dzieci z ostra białaczka limfoblastyczna.