[Current clinical interest in monitoring digoxinemia].
After a short introduction about the current role of digitalis in the treatment of the supraventrical arrhythmias and about the factors that make often problematic the achievement of an optimal posology of the drug, the results relative to more recent 340 digoxinaemia determinations in patients of Policlinico in Palermo or in outpatients are presented. Just the 43.8% of the patients had a digoxinaemia value in the range considered therapeutic; just 45 patients (32.1%), out of the 140 in which the digoxinaemia had been monitored for, at least, 5 days, were in the therapeutic range at the first determination; the 47.8% of the patients were underdosed and the 38.8% of them showed higher values than the therapeutic range. Determination 5 or more days later showed digoxinaemia values in the therapeutic range in 112 patients (80%). According to the reported results, it may be presumed that the posology correction effectuated by the physician on these patients might have been driven by the digoxinaemia values, whose determination must be considered an unavoidable guide to the digitalis treatment.
Salerno
L
L
Cattedra di Fisiopatologia Clinica, Università degli Studi di Palerma.
Di Fede
G
G
Pepe
S
S
Iacò
V
V
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000097:blood; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy*; D004071:Digitalis Glycosides / Q000008:administration & dosage* / Q000097:blood; D004077:Digoxin / Q000008:administration & dosage* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007558:Italy; D010818:Practice Patterns, Physicians'; D013617:Tachycardia, Supraventricular / Q000097:blood / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D004071:Digitalis Glycosides; D004077:Digoxin
Attualità dell'importanza clinica del monitoraggio della digossinemia.