Marine natural products. XXXVI. Biologically active polyacetylenes, adociacetylenes A, B, C, and D, from an Okinawan Marine sponge of Adocia sp.
Adociacetylenes A (1), B (2), C (3), and D (4) were isolated as new polyacetylenes from an Okinawan marine sponge of Adocia sp. Their chemical structures have been elucidated on the bases of their chemical and physicochemical properties. Adociacetylenes A (1), C (3), and D (4) exhibited inhibitory activity in the in vitro endothelial cell-neutrophil leukocyte adhesion assay.
Kobayashi
M
M
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Mahmud
T
T
Tajima
H
H
Wang
W
W
Aoki
S
S
Nakagawa
S
S
Mayumi
T
T
Kitagawa
I
I
D000114:Acetylene / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009504:Neutrophils / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D007166:Immunosuppressive Agents; D000114:Acetylene