[Recent prognostic factors in vulvar carcinoma: histological, immunohistochemical and flow cytometry studies].
OBJECTIVE
Are newer histologic investigations helpful in the evaluation of the prognosis of vulvar carcinoma?


METHODS
147 primary squamous cell carcinomas of the vulva were examined for overall- and disease-free survival (mean observation 59.6 months).


RESULTS
A significance in prognosis was found for FIGO-stage, a new-created histologic grade, p53- and vimentin-expression and amount of T-lymphocytes in tumoral stroma. Unfavourable prognosis was detected for tumors with elevated growth fraction, high proliferating cell-compartment (S + G2 + M) and increased cytokeratin-8-expression.


CONCLUSIONS
These investigations are able to describe the malignant potential of a vulvar carcinoma and should therefore influence the decision for a modified radical therapy.
Weikel
W
W
Universitätsfrauenklinik Mainz.
Beck
T
T
Moll
R
R
Brumm
C
C
Knapstein
P G
PG
D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D015996:Survival Rate; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000401:mortality / Q000473:pathology*
D014408:Biomarkers, Tumor
Neuere Prognosefaktoren des Vulvakarzinoms: Histologische, Immunhistochemische und durchflusszytometrische Untersuchungen.