Pharmacodynamics of torsemide administered as an intravenous injection and as a continuous infusion to patients with congestive heart failure.
The natriuretic and diuretic effects of a 100-mg dose of torsemide administered as a continuous infusion of torsemide and as a single bolus were compared in a group of patients with stable mild-to-moderate congestive heart failure (CHF). Patients received in random order 100 mg of torsemide as an intravenous bolus and as a 75-mg infusion over 24 hours started simultaneously with a 25-mg loading bolus. Administration of torsemide to patients with CHF as a continuous infusion was an effective dosing regimen, resulting in 24-hour diuresis and natriuresis that was numerically but not statistically greater than that observed with bolus administration. The response with continuous infusion occurred with less torsemide in the urine, resulting in a significantly greater efficiency of torsemide with this regimen. The effectiveness of torsemide as a continuous infusion does not mean that this mode of administration should be used in all patients. The response to 100 mg of torsemide in patients with mild-to-moderate CHF is the same whether administered as an intravenous bolus, a continuous intravenous infusion, or by mouth. This is consistent with the high bioavailability demonstrated in previous studies. The mode of therapy used should be dictated by each individual patient's needs. This study shows that continuous infusion is a viable option for administration of torsemide, and dosing guidelines for use of such a strategy are presented.
Kramer
W G
WG
Department of Clinical Research, Boehringer Mannheim Corporation, Gaithersburg, Maryland 20878-1952, USA.
Smith
W B
WB
Ferguson
J
J
Serpas
T
T
Grant
A G
AG
Black
P K
PK
Brater
D C
DC
D000328:Adult; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000652:urine; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology* / Q000652:urine; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D000077786:Torsemide