title: Tissue and serum concentrations of amikacin after intramuscular and intrauterine administration to mares in estrus.
abstract: Concentrations of amikacin in endometrial tissue and plasma were studied in mares in estrus after intrauterine infusion of 1.0 or 2.0 g once a day for 3 consecutive d, and after 9.7 or 14.5 mg/kg body weight (BW) had been injected intramuscularly once a day for 3 consecutive d to determine concentrations of amikacin sulfate in plasma and endometrial tissues, and whether parenteral administration provides any advantages over intramuscular infusion. No amikacin was detected in serum at the 1.0 g dose. At the infusion dose of 2.0 g once a day, very low levels of serum amikacin were detected at 1 and 4 h postinfusion on the 1st treatment day. Amikacin was found to penetrate the endometrium after intramuscular injection; however, the levels attained were not as high as those achieved following intrauterine infusion. Based on the tissue and serum concentrations of amikacin, an intrauterine infusion at a dose of 4.4 mg/kg BW/d would appear to be an appropriate therapeutic regimen for the treatment of gram-negative endometritis.
authors.affiliation: University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square 19348, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Orsini
authors.forename: M I
authors.initials: MI
authors.lastname: Park
authors.forename: P A
authors.initials: PA
authors.lastname: Spencer
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004717:Endometrium / Q000378:metabolism*; D004971:Estrus; D005260:Female; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular / Q000662:veterinary; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin