[Evaluation of urinary excretion of ethylenethiourea in subjects occupationally and non-occupationally exposed to ethylenebis(dithiocarbamates)].
Ethylenebisdithiorcabamate (EBDC) fungicides are broken down metabolically and in the environment to ethylenethiourea (ETU), a suspected carcinogen. Urinary ETU was assayed in control groups and subjects occupationaly exposed to EBDC and was found to be an excellent indicator of exposure both to ETU and EBDC. Correct use of protective clothing greatly reduced exposure and urinary excretion of ETU. ETU was excreted, albeit in low concentrations, in a high percentage (91% and 30%) of subjects in both control groups, demonstrating its utility as an indicator of widespread EBDC contamination.
Sciarra
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G
Istituto di Medicina del Lavoro, Università degli Studi di Siena.
Aprea
C
C
Sartorelli
P
P
D000382:Agricultural Workers' Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000652:urine; D002273:Carcinogens / Q000032:analysis* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003627:Data Interpretation, Statistical; D004781:Environmental Exposure; D005028:Ethylenebis(dithiocarbamates) / Q000009:adverse effects* / Q000378:metabolism; D005031:Ethylenethiourea / Q000032:analysis* / Q000378:metabolism; D005659:Fungicides, Industrial / Q000009:adverse effects; D006801:Humans; D008344:Maneb / Q000009:adverse effects / Q000378:metabolism; D016273:Occupational Exposure; D015038:Zineb / Q000009:adverse effects / Q000378:metabolism
D002273:Carcinogens; D005028:Ethylenebis(dithiocarbamates); D005659:Fungicides, Industrial; D008344:Maneb; D005031:Ethylenethiourea; C013099:mancozeb; D015038:Zineb
Valutazione dell'escrezione urinaria di etilentiourea in soggetti professionalmente e non professionalmente esposti ad etilenbisditiocarbammati.