title: Plasma von Willebrand factor antigen concentration and buccal mucosal bleeding time in dogs with experimental hypothyroidism.
abstract: This study was undertaken to investigate the effects of hypothyroidism on buccal mucosal bleeding time and von Willebrand factor antigen (vWf:Ag) concentrations. Hypothyroidism was induced in 8 adult dogs by administration of iodine 131. Four healthy dogs acted as controls. Measurement of plasma vWf:Ag and serum thyroxine and triiodothyronine concentrations, and buccal mucosal bleeding time were made before induction of hypothyroidism, for 23 weeks after 131I administration, and during 5 weeks of levothyroxine supplementation. No significant changes in buccal mucosal bleeding times were noted during the study. After an insignificant increase in vWf:Ag concentration in hypothyroid dogs, levothyroxine treatment was associated with a significant decrease in vWf:Ag concentration in hypothyroid dogs when compared with controls. Results of this study suggest that hypothyroidism does not induce acquired von Willebrand's disease or significant defects in primary hemostasis.
authors.affiliation: Department of Medical Sciences, University of Wisconsin, Madison 53706, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Panciera
authors.forename: G S
authors.initials: GS
authors.lastname: Johnson
mesh_terms: D000818:Animals; D001760:Bleeding Time; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007037:Hypothyroidism / Q000097:blood / Q000662:veterinary*; D008297:Male; D009061:Mouth Mucosa; D013972:Thyrotropin / Q000008:administration & dosage; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine