title: The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity.
abstract: Our findings reviewed in this article have revealed that the stimulation of opioid receptors of the hypothalamic neurons by interferon alpha and beta-endorphin synthesized in the brain or by stress causing the opioid-dependent analgesia suppresses the natural killer cytotoxicity, an important component of immunosurveillance, through an activation of the hypothalamic CRF-sympathetic nervous system.
authors.affiliation: Department of Physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Katafuchi
authors.forename: S
authors.initials: S
authors.lastname: Take
authors.forename: Y
authors.initials: Y
authors.lastname: Kaizuka
authors.forename: T
authors.initials: T
authors.lastname: Ichijo
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007031:Hypothalamus / Q000502:physiology*; D007108:Immune Tolerance / Q000502:physiology*; D007111:Immunity, Cellular; D007276:Injections, Intraventricular; D007370:Interferon Type I / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D051381:Rats; D011994:Recombinant Proteins; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D007370:Interferon Type I; D007375:Interleukin-1; D011994:Recombinant Proteins