[Development of immunosuppression and its correction with cell membrane stabilizers in burn trauma].
Degree IIIB burn suppresses the development of an immune response to T-dependent antigen. Following burn, substances having immunosuppressive active and inducing the emergence of suppressive properties in light erythrocytes occur in blood. Essentiale, alpha-tocopherol acetate and lidocaine enhance the development of an immune response to T-dependent antigen in burn injury. The administration of the drugs reduced the immunosuppressive activity of the sera from the burnt animals. Essentiale attenuated the immunosuppressive properties of red blood cells, while alpha-tocopherol acetate and lidocaine abolished them. Essentiale induced the occurrence of immunostimulating properties in heavy red blood cells from the burnt animals while alpha-tocopherol acetate and lidocaine enhanced the resistance of light erythrocytes to the burnt rat serum compounds that induced the emergence of immunosuppressive properties in the animals.
Bystrova
N A
NA
Miasnikov
A D
AD
Prokopenko
L G
LG
D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000276:immunology; D002462:Cell Membrane / Q000187:drug effects; D007108:Immune Tolerance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
Razvitie immunosupressii i ee korrektsiia stabilizatorami kletochnykh membran pri ozhogovoĭ travme.