[Molecular microheterogeneity of tumor marker substances and its significance of biological recognition].
It has been well known that molecular microheterogeneity of tumor marker substances have occasionally a big impact on the laboratory determination of tumor marker in sera. These includes molecular heterogeneity due to delicate difference of peptide or carbohydrate chain structures(CEA, AFP), the difference of epitope (CA19-9, CA125), the difference of combination of subunits(NSE) or the difference of combed other substances(PA). This paper reviewed such instances in terms of the definite data from our works or literatures.
Kuwabara
M
M
Department of Clinical Laboratory, Aichi Cancer Center.
Iwakoshi
N
N
Ariyoshi
Y
Y
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000737:chemistry*; D018395:CA-19-9 Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D017430:Prostate-Specific Antigen / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
D000888:Antibodies, Anti-Idiotypic; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins; D017430:Prostate-Specific Antigen; D010751:Phosphopyruvate Hydratase