title: Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen.
abstract: Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.
authors.affiliation: Abbott Laboratories, Abbott Park, Il. 60064, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Brill
authors.forename: W M
authors.initials: WM
authors.lastname: Kati
authors.forename: D
authors.initials: D
authors.lastname: Montgomery
authors.forename: J P
authors.initials: JP
authors.lastname: Karwowski
authors.forename: P E
authors.initials: PE
authors.lastname: Humphrey
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: J J
authors.initials: JJ
authors.lastname: Clement
authors.forename: S
authors.initials: S
authors.lastname: Kadam
authors.forename: R H
authors.initials: RH
authors.lastname: Chen
authors.forename: J B
authors.initials: JB
authors.lastname: McAlpine
mesh_terms: D002782:Cholestenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005670:Fusarium; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C100702:A 108835; C100701:A 108836; D002782:Cholestenes; D011480:Protease Inhibitors; D014315:Triterpenes