title: Maternal and perinatal implications of the use of human recombinant erythropoietin.
abstract: BACKGROUND
  The use of human recombinant erythropoietin (rHuEPO) in pregnant patients has been limited by the fear of eventual maternal and fetal repercussions (either direct or indirect).
  
  
  METHODS
  The authors present their experience with the use of rHuEPO during pregnancy, with two pregnant women with kidney transplants and in three others with chronic renal insufficiency (one with diabetic nephropathy, another dialysis dependent), all with hematocrit below 30% and adequate iron reserves.
  
  
  RESULTS
  Three of the patients had needed blood transfusions before beginning therapy, and another needed transfusion after significant metrorrhagia. The length of the treatment varied between 2 and 23 weeks and the hematocrit at delivery varied between 26% and 36%. Secondary effects (appearance or worsening of hypertension and seizures) were nil. There was one fetal death at 23 weeks of pregnancy (following an abruptio placenta), two neonates weighing between the 5th and the 10th percentiles, and three needing phototherapy (1 to 2 days). One year after birth, all showed a normal ponderal and neurologic development.
  
  
  CONCLUSIONS
  Among the cases presented, no maternal and perinatal complications attributable to rHuEPO were registered. It is important that institutions report their experiences with the use of rHuEPO, given its restrictive indications and the limited experience of each institution.
authors.affiliation: Department of Obstetrics and Materno-fetal Medicine, Hospital Geral de Santo António, Oporto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Braga
authors.forename: R
authors.initials: R
authors.lastname: Marques
authors.forename: A
authors.initials: A
authors.lastname: Branco
authors.forename: J
authors.initials: J
authors.lastname: Gonçalves
authors.forename: L
authors.initials: L
authors.lastname: Lobato
authors.forename: J P
authors.initials: JP
authors.lastname: Pimentel
authors.forename: M M
authors.initials: MM
authors.lastname: Flores
authors.forename: E
authors.initials: E
authors.lastname: Gonçalves
authors.forename: C S
authors.initials: CS
authors.lastname: Jorge
mesh_terms: D000328:Adult; D004921:Erythropoietin / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000209:etiology*; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000009:adverse effects*
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin