title: Synthesis and alpha,beta-adrenergic blocking potency of 2,3-dihydro-1,4-benzodioxin derivatives. (I).
abstract: The synthesis of a new series of alpha- and beta-adrenergic blocking agents 14 is described. The affinity and selectivity of these compounds for alpha, beta 1 and beta 2-adrenoceptors were studied in comparison with those of WB-4101 and propranolol. The derivatives 14cx and 14dx are more potent beta 1-blockers than propranolol.
authors.affiliation: Laboratoire de Chimie Bioorganique et Analytique, associé au CNRS, Université d'Orléans, France.
authors.forename: M
authors.initials: M
authors.lastname: Khouili
authors.forename: G
authors.initials: G
authors.lastname: Guillaumet
authors.forename: G
authors.initials: G
authors.lastname: Coudert
authors.forename: M D
authors.initials: MD
authors.lastname: Pujol
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D058671:Adrenergic beta-1 Receptor Antagonists; D058672:Adrenergic beta-2 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D004146:Dioxanes / Q000494:pharmacology; D004147:Dioxins / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D014132:Trachea / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D000317:Adrenergic alpha-Antagonists; D058671:Adrenergic beta-1 Receptor Antagonists; D058672:Adrenergic beta-2 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D004146:Dioxanes; D004147:Dioxins; D011433:Propranolol; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane