Budd-Chiari syndrome attributed to protein C deficiency.
The protein C anticoagulant pathway is an important downregulating mechanism of the blood coagulation cascade. We report a 47-yr-old male with Budd-Chiari syndrome and occlusion of the inferior vena cava. His plasma protein C antigen level was decreased to 42%, and its activity was 34%. Other coagulable factors were normal. Protein C deficiency should be considered a possible etiological factor of the Budd-Chiari syndrome.
Sugano
S
S
Department of Internal Medicine, Gastroenterology/Hepatology Division, Saiseikai Wakakusa Hospital, Yokohama, Japan.
Suzuki
T
T
Makino
H
H
Yanagimoto
S
S
Nishio
M
M
Onmura
H
H
Iinuma
M
M
Matuda
T
T
Shinozawa
Y
Y
D000437:Alcoholism / Q000150:complications; D006502:Budd-Chiari Syndrome / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020151:Protein C Deficiency; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology; D014682:Vena Cava, Inferior