Human skin contains luteinizing hormone/chorionic gonadotropin receptors.
Normal human skin contains a major 4.5 kb and several minor mRNA transcripts and a 66 kDa protein of luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptors which are capable of binding exogenous 125I-hCG. The distribution of receptor transcripts and receptor protein are the highest in epidermis followed by hair follicles, sebaceous and sweat glands. LH/hCG receptors are co-localized with androgen receptors in all the skin appendages. These data are the first demonstration of skin containing LH/hCG receptors and would suggest that LH and hCG may regulate skin functions.
Pabon
J E
JE
Department of Obstetrics and Gynecology, University of Louisville Medical Center, KY 40292, USA.
Bird
J S
JS
Li
X
X
Huang
Z H
ZH
Lei
Z M
ZM
Sanfilippo
J S
JS
Yussman
M A
MA
Rao
C V
CV
D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D007457:Iodine Radioisotopes; D012333:RNA, Messenger / Q000032:analysis; D011944:Receptors, Androgen / Q000032:analysis; D011974:Receptors, LH / Q000032:analysis* / Q000235:genetics; D012867:Skin / Q000737:chemistry*; D014018:Tissue Distribution
D006063:Chorionic Gonadotropin; D007457:Iodine Radioisotopes; D012333:RNA, Messenger; D011944:Receptors, Androgen; D011974:Receptors, LH