title: Acetogenins from Annonaceae, inhibitors of mitochondrial complex I.
abstract: One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).
authors.affiliation: Departamento de Farmacología (Farmacognosia y Farmacodinamia), Facultad de Farmacia, Universidad de Valencia, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Zafra-Polo
authors.forename: M C
authors.initials: MC
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: Estornell
authors.forename: S
authors.initials: S
authors.lastname: Sahpaz
authors.forename: D
authors.initials: D
authors.lastname: Cortes
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008928:Mitochondria / Q000201:enzymology*; D015394:Molecular Structure; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000037:antagonists & inhibitors*; D010944:Plants; D010946:Plants, Medicinal; D013045:Species Specificity
chemical_list: D004791:Enzyme Inhibitors; D005663:Furans; D016660:NAD(P)H Dehydrogenase (Quinone)