title: [Genetics and endocrinology of male sex differentiation: application to molecular study of male pseudohermaphroditism].
abstract: The various processes involved in sexual differentiation have been considerably clarified over the last few years through advances in biochemistry and molecular genetics. The cloning of the gene responsible for testicular determination SRY, of the anti-Müllerian hormone and anti-Müllerian hormone receptor genes, of the several steroidogenic enzymes genes, of the 5 alpha-reductase type 2 gene and of the androgen receptor gene has permitted to elucidate the molecular defects causing abnormal sexual differentiation. These data have brought a substantial impact on the understanding of human male sexual differentiation and its main disorders.
authors.affiliation: INSERM U439, Hôpital Lapeyronie, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Sultan
authors.forename: S
authors.initials: S
authors.lastname: Lumbroso
authors.forename: N
authors.initials: N
authors.lastname: Poujol
authors.forename: C
authors.initials: C
authors.lastname: Boudon
authors.forename: V
authors.initials: V
authors.lastname: Georget
authors.forename: B
authors.initials: B
authors.lastname: Térouanne
authors.forename: C
authors.initials: C
authors.lastname: Belon
authors.forename: J M
authors.initials: JM
authors.lastname: Lobaccaro
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000172:deficiency; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000172:deficiency; D000312:Adrenal Hyperplasia, Congenital / Q000201:enzymology; D000728:Androgens / Q000378:metabolism; D012734:Disorders of Sex Development / Q000235:genetics* / Q000378:metabolism*; D006059:Gonadal Dysgenesis / Q000235:genetics; D006801:Humans; D008297:Male; D012732:Sex Determination Analysis; D012733:Sex Differentiation; D013737:Testis / Q000002:abnormalities
chemical_list: D000728:Androgens; D015096:3-Hydroxysteroid Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase
vernacular_title: Génétique et endocrinologie de la différenciation sexuelle masculine: application à l'étude moléculaire des pseudohermaphrodismes masculins.