title: High-dose pelvic irradiation followed by ileal neobladder urinary diversion: complications and long-term results.
abstract: OBJECTIVE
  To determine the risk of post-operative complications in patients receiving high-dose pelvic irradiation before radical cystectomy and urinary diversion.
  
  
  METHODS
  Of 300 patients who underwent orthotopic bladder replacement at our institution from 1986 to 1994, 11 patients (mean age 63 years, range 53-74) did so after receiving high-dose pelvic irradiation. The indication for cystectomy and urinary reconstruction was bladder cancer in seven men, prostate cancer in two men and a contracted bladder due to combined external pelvic irradiation and afterloading radiotherapy in two women.
  
  
  RESULTS
  The post-operative course, including the duration of hospital stay, peri-operative complications and early functional results, did not differ from a control group of non-irradiated patients, and no patients died. The mean follow-up was 22 months (range 10-37) and revealed satisfactory results in seven of 11 patients. A neovesicoperitoneal fistula developed in one woman 10 months after surgery and was repaired by laparotomy. A neovesicovaginal fistula led to supravesical urinary diversion in the second woman.
  
  
  CONCLUSIONS
  High-dose pelvic irradiation should not be a primary contra-indication for orthotopic urinary diversion using segments of small intestine. For patients who undergo combined external and afterloading radiotherapy, the indication for orthotopic bladder replacement should be considered critically.
authors.affiliation: Department of Urology, University of Ulm, Germany.
authors.forename: J E
authors.initials: JE
authors.lastname: Gschwend
authors.forename: F
authors.initials: F
authors.lastname: May
authors.forename: T
authors.initials: T
authors.lastname: Paiss
authors.forename: H W
authors.initials: HW
authors.lastname: Gottfried
authors.forename: R E
authors.initials: RE
authors.lastname: Hautmann
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D015653:Cystectomy / Q000009:adverse effects / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000601:surgery; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D014547:Urinary Diversion / Q000009:adverse effects / Q000379:methods