title: [Correlation between an enzyme (glutathione S-transferase-pi) and effects of chemotherapy (cisplatin + etoposide)].
abstract: OBJECTIVE
  We studied the correlation between cisplatin and etoposide chemotherapy and GST-pi staining in patients with untreated primary non-small cell lung cancer.
  
  
  METHODS
  Of patients diagnosed as having primary lung cancer, 27 patients (26 men, 1 woman; median age 74.9 years) with stage III b or over were studied. Histological types included squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. A course of treatment consisted of cisplatin 100 mg/m2/day x one day and etoposide 100 mg/m2/day x 3 days during 28 days. After 2 courses of treatment, the therapeutic effects were judged and examined in relation to immunostaining levels obtained with anti-GST-pi antibody.
  
  
  RESULTS
  Of patients with PR (14), 11 showed GST-pi (-) staining.
  
  
  CONCLUSIONS
  There is a correlation between GST-pi staining and the effects of cisplatin and etoposide chemotherapy.
authors.affiliation: Dept. of Internal Medicine, Gihoku General Hospital, Gifu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Takaya
authors.forename: S
authors.initials: S
authors.lastname: Toshima
authors.forename: C
authors.initials: C
authors.lastname: Shibuya
authors.forename: M
authors.initials: M
authors.lastname: Nawada
authors.forename: M
authors.initials: M
authors.lastname: Shibayama
authors.forename: N
authors.initials: N
authors.lastname: Yoshimi
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000201:enzymology; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling
chemical_list: D005047:Etoposide; D005982:Glutathione Transferase; D002945:Cisplatin