Tetranitromethane as a broad spectrum disinfectant.
Tetranitromethane (TNM), a protein nitrating reagent, was shown to be effective in killing Gram-positive and Gram-negative bacteria, bacterial endospores and fungi. The killing action was greater in alkaline media, where nitration was most effective. TNM has a high affinity for hydrophobic solvents, and it is suggested that the reagent killed micro-organisms by nitrating critical membrane proteins.
Singh
J
J
Department of Microbiology and Immunology, University of Louisville, Kentucky 40292, USA.
Sonnenfeld
G
G
Doyle
R J
RJ
D001419:Bacteria / Q000187:drug effects; D004202:Disinfectants / Q000494:pharmacology*; D013774:Tetranitromethane / Q000494:pharmacology*
D004202:Disinfectants; D013774:Tetranitromethane