Mass vaccination to control chickenpox: the influence of zoster.
The impact of transmission events from patients with shingles (zoster) on the epidemiology of varicella is examined before and after the introduction of mass immunization by using a stochastic mathematical model of transmission dynamics. Reactivation of the virus is shown to damp stochastic fluctuations and move the dynamics toward simple annual oscillations. The force of infection due to zoster cases is estimated by comparison of simulated and observed incidence time series. The presence of infectious zoster cases reduces the tendency for mass immunization to increase varicella incidence at older ages when disease severity is typically greater.
Ferguson
N M
NM
Wellcome Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, United Kingdom.
Anderson
R M
RM
Garnett
G P
GP
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002644:Chickenpox / Q000453:epidemiology* / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D006562:Herpes Zoster / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D015994:Incidence; D007223:Infant; D008433:Mathematics; D008875:Middle Aged; D008962:Models, Theoretical; D013269:Stochastic Processes; D014611:Vaccination