title: Two-year follow-up study of the effect of acid fog on adult asthma patients.
abstract: Acid fog is a complex mixture of atomospheric pollutants containing multiple stimuli that may be capable of inducing bronchoconstriction. To investigate the effect of ambient acid fog on bronchoconstriction, we examined the relation between the hospital visit for asthma symptoms of 102 patients and various meteorological conditions for over the two-year period from January 1992 to December 1993. Dense fog occurs frequently every summer in Kushiro, a city located in Hokkaido, northernmost island in Japan. The acidity of the fog ranged from pH 3.32 to 6.91 (mean pH = 5.05) during this period. A significant increase (p < 0.05) of hospital visits on a foggy day was found in 9 cases, and a tendency (p < 0.10) was found in 10 cases. The odds ratio for a hospital visit on a high water vapor pressure day (> 12 h Pa) was significantly high (p < 0.01) in 5 cases among the above 19 cases. To exclude the effect of high water vapor pressure, the data was restricted to the condition of a foggy day with low water vapor pressure (< 12 hPa); 9 patients had a significant increase (p < 0.05) in hospital visits on such a day. These results indicated that hospital visits for asthma symptoms was increased on acid fog days in 8.8% of adult asthma patients. Inhalation of naturally occurring acid fog may have adverse effects on the respiratory tract of the asthmatic patient.
authors.affiliation: Third Department of Internal Medicine, Sapporo Medical University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Honma
authors.forename: M
authors.initials: M
authors.lastname: Nishi
authors.forename: T
authors.initials: T
authors.lastname: Igarashi
authors.forename: F
authors.initials: F
authors.lastname: Nishio
authors.forename: S
authors.initials: S
authors.lastname: Abe
mesh_terms: D000143:Acids / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D014887:Weather
chemical_list: D000143:Acids; D000336:Aerosols; D000393:Air Pollutants