title: [Recurrent arterial thromboembolism in hereditary hypoplasminogenaemia].
abstract: METHODS
  A 26-year-old man sustained a wasp bite 5 years ago which caused arterial embolism to the right brachial artery. Now he again had a wasp bite with allergic reaction and an arterial embolus to the left brachial artery. 2 days later, after embolectomy and heparinisation, he had a cerebrovascular accident due to an embolus to the left internal carotid artery. 15 days later, despite oral anticoagulation (Quick value 10%), he had an embolism to the left femoral artery.
  
  
  METHODS
  The source of the emboli was found by echocardiography to be a spherical floating thrombus on the aortic valve. The plasminogen level was only 45-61%. His mother and sister also had a low plasminogen level, i.e. he had congenital plasminogen deficiency.
  
  
  METHODS
  At surgery, when the thrombus had been removed, a slit-like defect was found on one of the aortic leaflets and covered with a pericardial patch. At first heparin then phenprocoumon were administered, plus 250 mg ticlopidine twice daily. There have been no further complications.
  
  
  CONCLUSIONS
  As the patient's fibrinolysis activity was normal, additional, probably allergic, factors must have been present to disturb the equilibrium between thrombogenesis and fibrinolysis thus causing thrombosis at a predisposed site.
authors.affiliation: Medizinische Klinik und Poliklinik der Universität, Bonn.
authors.forename: A
authors.initials: A
authors.lastname: Hagendorff
authors.forename: H J
authors.initials: HJ
authors.lastname: Hertfelder
authors.forename: W
authors.initials: W
authors.lastname: Fehske
authors.forename: P G
authors.initials: PG
authors.lastname: Kirchhoff
authors.forename: P
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000601:surgery; D017128:Embolectomy; D006402:Hematologic Diseases / Q000151:congenital* / Q000235:genetics; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000172:deficiency* / Q000235:genetics; D017354:Point Mutation; D011655:Pulmonary Embolism / Q000209:etiology; D012008:Recurrence; D013923:Thromboembolism / Q000175:diagnosis / Q000209:etiology*
chemical_list: D010958:Plasminogen
vernacular_title: Rezidivierende arterielle Thromboembolien bei hereditärer Hypoplasminogenämie.