[Plasma fibrin monitor level in DIC patients with a hematopoietic malignancy].
The Plasma level of soluble fibrin monomer (sFM) was measured in 218 patients with a hematopoietic malignancy. Of them, 198 were diagnosed with disseminates intravascular coagulation (DIC), 20 with Pre-DIC, and 20 with Non-DIC. Pre-DIC was retrospectively defined as the condition at least 1 week before the onset of DIC. The plasma levels of sFM, thrombin-anti-thrombin III complex (TAT), plasmin alpha 2-antiplasmin inhibitor complex (PIC), and FDP-D-dimer were significantly higher in patients with DIC than in those with Non-DIC. These levels were significantly higher in patients with Pre-DIC than in those with Non-DIC. Among these hemostatic parameters, the plasma sFM showed the highest sensitivity and specificity for DIC or Pre-DIC. These findings suggests that sFM is the most valuable marker hemostatic for the diagnosis of DIC and Pre-DIC.
Hiyoyama
K
K
2nd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Wada
H
H
Shimura
M
M
Deguchi
H
H
Nagaya
S
S
Wakita
Y
Y
Deguchi
K
K
Shiku
H
H
D015415:Biomarkers / Q000032:analysis; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis*; D005337:Fibrin / Q000032:analysis*; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D012189:Retrospective Studies
D015415:Biomarkers; D005337:Fibrin