Mobile lipid accumulation in necrotic tissue of high grade astrocytomas.
Multiple samples from 42 astrocytomas were investigated ex vivo by 1H MR spectroscopy followed by histological assessment. MR visible lipids were detected in 27 of 32 grade 4 astrocytomas. These lipids were heterogeneously distributed within the tumours. Their amount correlated positively with the amount of histologically detected necrosis. Mobile lipids were also observed in grade 4 astrocytoma samples without necrosis, as well as in one of three grade 3, two of three grade 2 and two of four grade 1 astrocytomas. The clinical significance of MR visible lipids, their cellular location, and their possible biological bases are discussed.
Kuesel
A C
AC
Institute of Biodiagnostics, NRC, Winnipeg, MB, Canada.
Briere
K M
KM
Halliday
W C
WC
Sutherland
G R
GR
Donnelly
S M
SM
Smith
I C
IC
D001254:Astrocytoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy; D009336:Necrosis