Primary and secondary results of the modification of diet in renal disease study.
The modification of diet in renal disease (MDRD) study was a prospective, randomized, multicenter trial in 840 patients with chronic renal disease of diverse etiology. Patients in study A (585) had a GFR of 25-55 ml/min at baseline and patients in study B (255) had a GFR of 13-24 ml/min. After randomization to different diet and blood pressure groups the mean follow-up was 2.2 years. The results of the blood pressure and dietary interventions on GFR decline with time are summarized.
Klahr
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Department of Medicine, Washington University School of Medicine at The Jewish Hospital of St. Louis, Mo 63110, USA.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D018753:Diet, Protein-Restricted; D005500:Follow-Up Studies; D005527:Food, Fortified; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000178:diet therapy* / Q000503:physiopathology*; D008875:Middle Aged; D009748:Nutrition Disorders; D011446:Prospective Studies; D011507:Proteinuria; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors; D014168:Transferrin / Q000032:analysis
D000596:Amino Acids; D000959:Antihypertensive Agents; D012709:Serum Albumin; D014168:Transferrin