[Study of the expression of proliferating cell nuclear antigen and p185 in non-small cell lung carcinoma].
We assessed immunohistochemical expression of p185 and the proliferating cell nuclear antigen (PCNA) in 68 patients undergoing surgery for non-small cell lung cancer. Adenocarcinoma of the lung was the histological type whose expression of p185 at levels exceeding 10% was greater to a statistically significant degree. Epidermoid carcinoma, on the other hand, was associated with the highest PCNA indices. Although these 2 markers had no prognostic value in the survival study, it must be pointed out that the longest survivors were patients with p185 expression less than 10% in neoplastic cells.
Alemany Monraval
P
P
Servicio de Anatomía Patológica, Hospital General Universitario de Valencia.
Martorell Cebollada
M
M
Salvador Villalba
I
I
Martínez Leandro
E
E
D000230:Adenocarcinoma / Q000737:chemistry / Q000401:mortality; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000401:mortality; D003627:Data Interpretation, Statistical; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D013997:Time Factors
D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases
Estudio de la expresión del antígeno nuclear de proliferación celular y p185 en el carcinoma no microcítico de pulmón.