Flumazenil: an unreliable antagonist in baclofen overdose.
We report a case of inadvertent overdose of baclofen given intrathecally resulting in coma. This was unresponsive to flumazenil and required supportive intensive therapy. With the increasing use of baclofen intrathecally for spasticity and its wide interpatient dose variability, there is a need to find a safe antagonist to baclofen for routine medical use.
Byrnes
S M
SM
Department of Anaesthetics, Gloucestershire Royal Hospital.
Watson
G W
GW
Hardy
P A
PA
D000328:Adult; D000931:Antidotes / Q000494:pharmacology*; D001418:Baclofen / Q000037:antagonists & inhibitors* / Q000506:poisoning; D003128:Coma / Q000139:chemically induced; D005260:Female; D005442:Flumazenil / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology; D006801:Humans; D009125:Muscle Relaxants, Central / Q000037:antagonists & inhibitors* / Q000506:poisoning
D000931:Antidotes; D018757:GABA Modulators; D009125:Muscle Relaxants, Central; D005442:Flumazenil; D001418:Baclofen