[GnRH antagonists in gynecology: initial results within the scope of controlled ovarian hyperstimulation].
OBJECTIVE
Applicability of the GnRH-antagonist Cetrorelix within controlled ovarian hyperstimulation (COH) to avoid the premature LH-surge should be examined.


METHODS
35 patients suffering from tubal infertility were stimulated for In Vitro Fertilization (IVF) by human menopausal gonadotrophins (HMG) and concomitant administration of Cetrorelix in different dosages (3 mg, 1 mg, 0,5 mg).


RESULTS
No premature LH-surge could be observed.


CONCLUSIONS
Short term administration of the GnGR-antagonists avoids the occurrence of a premature LH-surge.
Felberbaum
R
R
Klinik für Frauenheilkunde und Geburtshilfe der Medizinischen Universität zu Lübeck.
Reissmann
T
T
Zoll
C
C
Küpker
W
W
al-Hasani
S
S
Diedrich
C
C
Diedrich
K
K
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D011247:Pregnancy
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; C062876:cetrorelix
Die GnRH-Antagonisten in der Gynäkologie: Erste Ergebnisse im Rahmen der kontrollierten ovariellen Hyperstimulation (COH).