Comparison of four homologous retention index standard series for qualitative gas chromatography of nitrogenous acidic and neutral drugs.
Four homologous retention index standard series, the alkylmethylhydantoins, alkylhydantoins, alkylmaleimides and alkylbis(trifluoromethyl)phosphine sulphides, were evaluated for the screening of blood samples for acidic and neutral drugs on Ultra 2 and HP-1701 capillary columns over a six-month period. An index series consisting of actual drug substances was used as a standard of comparison. All the series produced high precision, and the precision differences between the series were rather small. Considering the limitations of the other series, the alkylmethylhydantoins and alkylhydantoins turned out to be the most feasible internal retention index standard series in the present dual column setting.
Rasanen
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I
Department of Forensic Medicine, University of Helsinki, Finland.
Ojanperä
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I
Vuori
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E
Hase
T A
TA
D001774:Blood Chemical Analysis; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations