[The effect of streptococcal group A polysaccharide on PHA-induced T-cell proliferation].
The influence of group A streptococcal polysaccharide (A-PS) on the proliferation and functional activity of subpopulations CD4+ and CD8+ of human peripheral blood lymphocytes has been studied. As revealed in this study, A-PS, though having no mitogenic activity of its own, is capable of influencing the process of proliferation of two main T-cell subpopulations in the presence of PHA. Its action has a regulatory character and is manifested by the maintenance of the ration of lymphocytes CD4+ and CD8+ in the culture at a constant level (approximating 1). This effect is seemingly linked with changes in the functional activity of lymphocytes in both subpopulation CD4+ and subpopulation CD8+. The detected properties of A-PS make it possible to regard it as a pathogenic factor playing an important role in immunoregulatory disturbances in diseases connected with infection caused by group A streptococcus.
Bazanova
E A
EA
Gnezditskaia
E V
EV
Nesterenko
V G
VG
Popova
L K
LK
Sanina
V Iu
VIu
Ignatenko
I N
IN
D000328:Adult; D016516:CD4-CD8 Ratio / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013297:Streptococcus pyogenes
D010835:Phytohemagglutinins; D011135:Polysaccharides, Bacterial
Vliianie polisakharida streptokokka gruppy A na proliferatsiiu T-kletok, indutsirovannuiu FGA.