title: Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism.
abstract: The plant hormone auxin regulates various developmental processes including root formation, vascular development, and gravitropism. Mutations within the AUX1 gene confer an auxin-resistant root growth phenotype and abolish root gravitropic curvature. Polypeptide sequence similarity to amino acid permeases suggests that AUX1 mediates the transport of an amino acid-like signaling molecule. Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product. The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bennett
authors.forename: A
authors.initials: A
authors.lastname: Marchant
authors.forename: H G
authors.initials: HG
authors.lastname: Green
authors.forename: S T
authors.initials: ST
authors.lastname: May
authors.forename: S P
authors.initials: SP
authors.lastname: Ward
authors.forename: P A
authors.initials: PA
authors.lastname: Millner
authors.forename: A R
authors.initials: AR
authors.lastname: Walker
authors.forename: B
authors.initials: B
authors.lastname: Schulz
authors.forename: K A
authors.initials: KA
authors.lastname: Feldmann
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology; D000595:Amino Acid Sequence; D026905:Amino Acid Transport Systems; D000596:Amino Acids / Q000378:metabolism; D017360:Arabidopsis / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029681:Arabidopsis Proteins; D001692:Biological Transport; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D017343:Genes, Plant; D005816:Genetic Complementation Test; D018522:Gravitropism; D007210:Indoleacetic Acids / Q000378:metabolism / Q000494:pharmacology; D026901:Membrane Transport Proteins / Q000737:chemistry; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009154:Mutation; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D018517:Plant Roots / Q000254:growth & development* / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction
chemical_list: C100794:AUX1 protein, Arabidopsis; D026905:Amino Acid Transport Systems; D000596:Amino Acids; D029681:Arabidopsis Proteins; D004269:DNA, Bacterial; D007210:Indoleacetic Acids; D026901:Membrane Transport Proteins; D010940:Plant Proteins; C036483:T-DNA; D015084:2,4-Dichlorophenoxyacetic Acid; C030737:indoleacetic acid