[The central hemodynamic changes and reaction of the sympathoadrenal system with the use of an original Russian analgesic fenaridin as the analgetic component of general anesthesia during aortocoronary bypass operations in patients with chronic ischemic heart disease].
The effect of fenaridine on the central hemodynamics and sympathoadrenal system was studied in 12 chronic coronary patients subjected to aortocoronary shunting and administered this drug as an analgetic component of general anesthesia. A reduction of heart rate, systolic arterial pressure, pressure in the pulmonary artery, total pulmonary resistance, more expressed decrease of cardiac index and stroke index, and an increase of total peripheral vascular resistance were observed. Analysis of the results permitted us to propose vasodilating effect of the drug, leading to a moderate reduction of cardiac index, and followed by a compensatory increase of vascular resistance, as the basic mechanism of these changes. These shifts cannot be induced by improper anesthesia, which was confirmed by the results of examining the sympathoadrenal system.
Tenshibaeva
D A
DA
Kolesnik
T F
TF
Kuznetsova
B A
BA
Fokina
N S
NS
D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000311:Adrenal Glands / Q000187:drug effects* / Q000503:physiopathology; D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology; D000768:Anesthesia, General / Q000379:methods*; D002908:Chronic Disease; D001026:Coronary Artery Bypass / Q000379:methods*; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000601:surgery*; D011229:Preanesthetic Medication; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology
D000701:Analgesics, Opioid; D015761:4-Aminopyridine; C054783:phenaridine
Izmeneniia tsentral'noĭ gemodinamiki i reaktsiia simpatiko-adrenalovoĭ sistemy pri primenenii original'nogo otechestvennogo analgetika fenaridina v kachestve analgeticheskogo komponenta obshcheĭ anestezii vo vremia operatsiĭ aortokoronarnogo shuntirovaniia u bol'nykh khronicheskoĭ ishemicheskoĭ bolezn'iu serdtsa.