A rare case of idiopathic hypoparathyroidism with varied neurological manifestations.
A 47-year-old man was admitted for evaluation of unsteady gait, postural instability, and dysarthria. On admission, neurological examinations revealed cerebellar ataxia, extrapyramidal signs including parkinsonism and positive Trousseau's sign. Laboratory findings revealed severe hypocalcemia and hyperphosphatemia, and serum intact parathyroid hormone was not detectable. Brain computed tomography revealed severe calcification of basal ganglia and dentate nuclei. He was diagnosed as idiopathic hypoparathyroidism; treatment with 1 alpha (OH) vitamin D3 brought marked improvement of neurological manifestations. We report a rare case of idiopathic hypoparathyroidism presenting with extrapyramidal and cerebellar dysfunction with a review of literature.
Abe
S
S
Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo.
Tojo
K
K
Ichida
K
K
Shigematsu
T
T
Hasegawa
T
T
Morita
M
M
Sakai
O
O
D001479:Basal Ganglia / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002117:Calcitriol / Q000627:therapeutic use; D002524:Cerebellar Ataxia / Q000209:etiology / Q000473:pathology; D002529:Cerebellar Nuclei / Q000473:pathology*; D006801:Humans; D006996:Hypocalcemia / Q000150:complications / Q000188:drug therapy; D007011:Hypoparathyroidism / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D014057:Tomography, X-Ray Computed
D010281:Parathyroid Hormone; D010710:Phosphates; D002117:Calcitriol