[Acute cerebellar syndrome after treatment with 5-fluorouracil].
We report on a case of 5-fluorouracil induced neurotoxicity during 5-fluorouracil cisplatin combination chemotherapy for advanced head and neck squamous cell carcinoma. The initial manifestations included an acute cerebellar syndrome and peripheral neuropathy. Computed tomography of the brain was normal. The results of nerve-conduction studies were compatible with the diagnosis of distal sensory neuropathy. The patient experienced improvement, without treatment, four weeks after cessation of chemotherapy. The role of cisplatin and alcohol abuse in this neurotoxic episode, can not yet completely be excluded.
Barbieux
C
C
Service de médecine interne I, hôpital Boucicaut, Paris, France.
Patri
B
B
Cerf
I
I
de Parades
V
V
D000437:Alcoholism / Q000150:complications; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D002945:Cisplatin / Q000009:adverse effects; D003937:Diagnosis, Differential; D004361:Drug Tolerance; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D014067:Tonsillar Neoplasms / Q000188:drug therapy*
D002945:Cisplatin; D005472:Fluorouracil
Syndrome cérébelleux aigu après traitement par le 5-fluorouracile.