Sampling distributions of p(pos) and p(neg).
In the absence of a gold standard, assessment of clinimetric properties of dichotomous variables should include reporting of the proportions of positive agreement (ppos) and negative agreement (pneg). For example, for a patient considering whether or not to undergo elective surgery, ppos represents the probability that a second physician would concur with a recommendation to undergo surgery and pneg represents the probability that a second physician would concur with a recommendation not to undergo surgery. This article uses a conditional binomial distribution to derive the sampling distributions of ppos and pneg. The sampling distribution can be used as a basis for confidence intervals and hypothesis tests.
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Center for Health Services Research in Primary Care, Department of Veterans Affairs, Medical Center, Durham, North Carolina, USA.
D016001:Confidence Intervals; D006801:Humans; D015233:Models, Statistical; D015588:Observer Variation; D015203:Reproducibility of Results