title: Continuous extradural infusion of ropivacaine for prevention of postoperative pain after major orthopaedic surgery.
abstract: We studied 151 patients undergoing total hip or knee arthroplasty, or cruciate ligament reconstruction in a multicentre study in Australia and New Zealand. Patients were openly allocated randomly to one of five treatment groups or to a control group. General anaesthesia was induced after introduction of extradural block with 0.5% ropivacaine. After surgery, patients received an extradural infusion of 0.2% ropivacaine at 6, 8, 10, 12 or 14 ml h-1 or received no postoperative extradural infusion (control group). All patients had access to i.v. PCA morphine for supplementary analgesia. Morphine consumption was lower in all treatment groups compared with the control group, decreasing with increasing ropivacaine infusion rate. Median VAS scores were lower in all ropivacaine infusion groups compared with the control group for the first 10 h of the study; however by the end of the study, VAS scores were similar in all groups. The higher ropivacaine infusion rates caused a slower convergence of spread of the initial sensory block and a higher degree of motor block. The overall incidence of side effects was similar, with the exception of a higher incidence of urinary retention and hypotension in the groups receiving the higher rates of ropivacaine. The quality of treatment scores were similar for all treatment groups (Br. J. Anaesth. 1996; 76: 606-610).
authors.affiliation: Royal Perth Hospital, WA, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Turner
authors.forename: D
authors.initials: D
authors.lastname: Blake
authors.forename: M
authors.initials: M
authors.lastname: Buckland
authors.forename: D
authors.initials: D
authors.lastname: Chamley
authors.forename: P
authors.initials: P
authors.lastname: Dawson
authors.forename: C
authors.initials: C
authors.lastname: Goodchild
authors.forename: J
authors.initials: J
authors.lastname: Mezzatesta
authors.forename: D
authors.initials: D
authors.lastname: Scott
authors.forename: A
authors.initials: A
authors.lastname: Sultana
authors.forename: S
authors.initials: S
authors.lastname: Walker
authors.forename: M
authors.initials: M
authors.lastname: Hendrata
authors.forename: P
authors.initials: P
authors.lastname: Mooney
authors.forename: M
authors.initials: M
authors.lastname: Armstrong
mesh_terms: D000328:Adult; D000368:Aged; D000577:Amides; D016058:Analgesia, Patient-Controlled; D000779:Anesthetics, Local; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007268:Injections, Epidural; D007720:Knee Prosthesis; D008023:Ligaments, Articular / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D000077212:Ropivacaine; D013997:Time Factors
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D009020:Morphine; D000077212:Ropivacaine