[Serum levels of soluble adhesion molecules in patients with inflammatory myopathies].
Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured by ELISA in patients with 18 inflammatory myopathies as well as 23 healthy controls. Both serum sICAM-1 and sVCAM-1 levels were elevated in patients with active polymyositis. Serum sVCAM-1 levels were elevated in the active stage of dermatomyositis, while sICAM-1 levels were elevated only in patients with dermatomyositis complicated with interstitial pneumonia. In paired serum samples before and after prednisolone therapy, elevated serum sICAM-1 and sVCAM-1 levels decreased in patients responding well to steroid therapy without complications. These findings suggested that soluble adhesion molecules reflect as the clinical activity of inflammatory myopathies.
Murata
K
K
Department of Neurology, Nara Medical University.
Takayanagi
T
T
Mano
Y
Y
Miyagawa
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003882:Dermatomyositis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000097:blood* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012995:Solubility; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D000893:Anti-Inflammatory Agents; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D011239:Prednisolone