Modification of pain on injection of propofol. A comparison of pethidine and lignocaine.
One hundred and fifty ASA 1 and 2 patients were randomly allocated to receive pethidine 25 mg (1 ml), lignocaine 10 mg (1 ml) or 0.9% saline (1 ml) on a double-blind basis, as pretreatment to reduce pain on injection of propofol. Both active treatments were significantly better than placebo at preventing pain (p < 0.01). Lignocaine was most effective in preventing pain in men (p < 0.05) whilst pethidine was more effective in women (p < 0.05).
Lyons
B
B
Department of Anaesthesia, Cappagh Orthopaedic Hospital, Dublin, Ireland.
Lohan
D
D
Flynn
C
C
McCarroll
M
M
D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects*; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008614:Meperidine / Q000627:therapeutic use; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D012737:Sex Factors
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D008012:Lidocaine; D008614:Meperidine; D015742:Propofol