title: Somatostatin receptor scintigraphy in the staging of small cell lung cancer.
abstract: The aim of this study was to evaluate somatostatin receptor scintigraphy (SRS) in the staging of patients with small cell lung cancer. Prior to chemotherapy, 20 patients were investigated up to 24 h following an injection of 200 MBq 111In-octreotide. Following chemotherapy and restaging, four patients were re-evaluated. Primary tumour was detected in 18 of 23 studies, which exhibited increasing target-to-back-ground ratios over time. Lymph node metastases and distant metastases were detected in 7 of 27 and 8 of 31 sites, respectively. Thus, the overall sensitivity for detecting metastases was less than 26%. SRS did not result in any upstaging of patients. We conclude that in patients with small cell lung cancer, functional imaging by SRS has no impact on clinical decision making.
authors.affiliation: Clinic of Nuclear Medicine, Christian-Albrechts-Universität Kiel, Germany.
authors.forename: K H
authors.initials: KH
authors.lastname: Bohuslavizki
authors.forename: W
authors.initials: W
authors.lastname: Brenner
authors.forename: M
authors.initials: M
authors.lastname: Günther
authors.forename: J U
authors.initials: JU
authors.lastname: Eberhardt
authors.forename: N
authors.initials: N
authors.lastname: Jahn
authors.forename: S
authors.initials: S
authors.lastname: Tinnemeyer
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: C
authors.initials: C
authors.lastname: Sippel
authors.forename: M
authors.initials: M
authors.lastname: Clausen
authors.forename: U
authors.initials: U
authors.lastname: Gatzemeier
authors.forename: E
authors.initials: E
authors.lastname: Henze
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods; D015282:Octreotide / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; C094279:indium-111-octreotide; D015282:Octreotide