[Unusual relapse for neuroblastoma. Case of an intracranial relapse].
The usual sites of initial metastatic deposits in neuroblastoma are osteo-medullary. With modern therapies including megatherapy and hematopoietic rescue, prolonged survival is obtained. However, unusual metastatic sites are more and more often described during the prolonged evolution of these patients such as brain metastases. A case of isolated intracerebral metastatic relapse is reported here in a patient who had received 4 months before a megatherapy in first complete remission. Pathogeny and therapeutical implications are discussed.
Frappaz
D
D
Département de Pédiatrie et d'Immunologie, Centre Léon-Bérard, Lyon, France.
Marec Bérard
P
P
Combaret
V
V
Thiesse
P
P
Basset
T
T
Bouffet
E
E
Pouyau
G
G
Desuzinges
C
C
Brunat Mentigny
M
M
Philip
T
T
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery
Rechute inhabituelle de neuroblastome. A propos d'une récidive intracrânienne.