title: A combination of vinblastine and doxorubicin with interferon alpha.
abstract: Advanced renal cell carcinoma still has poor overall treatment results, whatever chemotherapy is used. We treated 11 patients with advanced renal cell carcinoma with vinblastine (4 mg/m2) and doxorubicin (12 mg/m2) weekly, combined with recombinant IFN-alpha 2a given 3 x 10(6) IU s.c. three times per week during the first week, and 9 x 10(6) IU three times per week during the second week, and then on an ongoing basis 18 x 10(6) IU three times per week from the third week. The treatment of all patients had to be interrupted after 6 to 9 weeks because of leukopenia. Median survival was 6 months, and two partial responses were observed. We conclude that this regimen proved to be excessively toxic and failed to show significant advances compared with two-drug combination.
authors.affiliation: Department of Oncology, Helsinki University Central Hospital, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Jekunen
authors.forename: S
authors.initials: S
authors.lastname: Pyrhönen
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D007680:Kidney Neoplasms / Q000188:drug therapy*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D015996:Survival Rate; D014747:Vinblastine / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014747:Vinblastine; D004317:Doxorubicin