Efficacy of disinfectants against biofilm cells of methicillin-resistant Staphylococcus aureus.
The effect of disinfectants on biofilm cells of methicillin-resistant Staphylococcus aureus (MRSA) was evaluated. Eradication of biofilm cells of MRSA by chlorhexidine gluconate, benzalkonium chloride, alkyldiaminoethyl glycine and sodium hypochlorite required a much longer time than that of planktonic cells in suspensions. Benzalkonium chloride (0.1%) and alkyldiaminoethyl glycine (0.1%) were ineffective for eradication of biofilm cells even after 1 h, but were effective for eradication of planktonic cells within 20 s. Sodium hypochlorite (0.01%) was also ineffective for eradication of biofilm cells even after 30 min, but was lethal to planktonic cells within 20 s.
Oie
S
S
Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan.
Huang
Y
Y
Kamiya
A
A
Konishi
H
H
Nakazawa
T
T
D018441:Biofilms / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D016106:Methicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*
D004202:Disinfectants