Successful eradicating treatment of Helicobacter pylori in patients with chronic gastritis: gastric levels of cytokines, epidermal growth factor and polyamines before and after therapy.
In 10 patients with Helicobacter pylori (HP) positive chronic gastritis, gastric mucosal content of interleukin (IL)-1 beta, IL-8, Transforming Growth Factor (TGF)-beta 1, Epidermal Growth Factor (EGF) and Polyamines (putrescine, spermine and spermidine) was evaluated before and after eradicating treatment. Histologically, in all patients eradication of HP was accompanied by a marked reduction of the inflammatory infiltrate. At the same time, at the end of the therapeutical regimen, elevated levels of IL-1 beta, IL-8, TGF-beta 1, putrescine and spermidine/spermine ratio significantly dropped, while EGF mucosal content, significantly increased. Results are discussed in terms of the reciprocal role of inflammatory cytokines, growth factors and polyamines in the evolution of the HP-associated chronic gastritis.
Messa
C
C
Laboratory of Biochemistry, University of Bari, Italy.
Di Leo
A
A
Greco
B
B
Caradonna
L
L
Amati
L
L
Linsalata
M
M
Giorgio
I
I
Jirillo
E
E
D016207:Cytokines / Q000187:drug effects / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000032:analysis*; D005753:Gastric Mucosa / Q000737:chemistry* / Q000187:drug effects; D005757:Gastritis, Atrophic / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D011073:Polyamines / Q000032:analysis*
D016207:Cytokines; D011073:Polyamines; D004815:Epidermal Growth Factor