Oxidative stress in rat liver and lung induced by furanoterpenoids isolated from Fusarium solani infected sweet potatoes.
A crude extract containing some toxic furanoterpenoids was isolated from F. solani infected sweet potatoes. Chronic administration of the crude extract to male albino rats at a dosage of 1 mg/kg body weight/day for 21 days brought about a sharp increase in the thiobarbituric acid reactive substances and a depression of glutathione levels in the lung and liver homogenates. The antioxidant defense system was affected as evident from a significant fall in the activities of the enzymes, superoxide dismutase, catalase, glutathione peroxidase, glucose-6-phosphate dehydrogenase and glutathione-S-transferase. Such an alteration could be the reason for the lung and liver damage caused by these toxic furanoterpenoids.
Rajendran
S
S
Department of Biochemistry, University of Madras, India.
Parasakthy
K
K
Deepalakshmi
P D
PD
Devaraj
S N
SN
D000818:Animals; D005663:Furans / Q000302:isolation & purification*; D005670:Fusarium / Q000378:metabolism / Q000502:physiology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009181:Mycoses / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000302:isolation & purification*; D014675:Vegetables / Q000378:metabolism / Q000382:microbiology*
D005663:Furans; D013729:Terpenes