The biology of HMG-CoA reductase: the pros of contra-regulation.
Hydroxymethylglutaryl-CoA reductase (HMG-R) is a key enzyme in the mevalonate pathway, from which thousands of molecules are derived including cholesterol and prenyl moieties. The regulation of HMG-R is complex and includes feedback control, cross-regulation by independent bio-chemical processes and contra-regulation of separate isozymes. From studies in yeast, these separate modes of regulation can be considered in an integrated fashion.
Hampton
R
R
Department of Biology, University of California, San Diego, La Jolla 92093, USA.
Dimster-Denk
D
D
Rine
J
J
D005246:Feedback; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000502:physiology*; D007527:Isoenzymes / Q000502:physiology*; D005810:Multigene Family; D012441:Saccharomyces cerevisiae / Q000201:enzymology
D007527:Isoenzymes; D006903:Hydroxymethylglutaryl CoA Reductases