title: Loss of an X chromosome in aggressive angiomyxoma of female soft parts: a case report.
abstract: Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X,-X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridization (FISH) performed on disaggregated cells from paraffin embedded lesional tissue confirmed loss of an X chromosome in 31% of cells. Cytogenetic analysis performed on peripheral blood showed a normal chromosomal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously described in aggressive angiomyxoma.
authors.affiliation: Department of Pathology, University of Nebraska Medical Center, Omalia, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Kenny-Moynihan
authors.forename: J
authors.initials: J
authors.lastname: Hagen
authors.forename: B
authors.initials: B
authors.lastname: Richman
authors.forename: D G
authors.initials: DG
authors.lastname: McIntosh
authors.forename: J A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000293:Adolescent; D002872:Chromosome Deletion; D005260:Female; D006801:Humans; D009232:Myxoma / Q000235:genetics*; D014846:Vulvar Neoplasms / Q000235:genetics*; D014960:X Chromosome