title: Non-Hodgkin's lymphoma after liver transplantation: response to chemotherapy.
abstract: An increased incidence of lymphoproliferative disorders in immunosuppressed organ transplant recipients has long been recognised. Lymphoproliferative disorders occur in 2% of orthotopic liver transplant patients. Different therapies have been used, but the optimal treatment remains unknown. Relatively little information is available on experience with cytotoxic chemotherapy. Three children who developed Burkitt-like, non-Hodgkin's lymphomas after liver transplantation are described. The disease failed to regress after initial management, which included a reduction in immunosuppression. With cytotoxic chemotherapy all three achieved complete remission, which continued 36+, 35+, and 16+ months after diagnosis. Results suggest that in selected cases chemotherapy can be safe in late-onset lymphomas appearing after solid organ transplantation.
authors.affiliation: Unit of Pediatric Oncology, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Gallego-Melcón
authors.forename: J
authors.initials: J
authors.lastname: Sánchez de Toledo
authors.forename: V
authors.initials: V
authors.lastname: Martínez
authors.forename: F
authors.initials: F
authors.lastname: Moraga
authors.forename: J
authors.initials: J
authors.lastname: Iglesias
authors.forename: C
authors.initials: C
authors.lastname: Ruiz
authors.forename: E
authors.initials: E
authors.lastname: Allende
mesh_terms: D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male