[Schematic model of genesis of osteosarcoma induced by Sr-90].
The development of radiation osteosarcoma genesis scheme induced by 90Sr was the subject of the present study. The production of cancer cells after exposure to a specific dose-rate of emitting 90Sr incorporated in the skeleton are typical for the initiation period. However not all the cells remain in the mutant DNA. In some of them DNA reparation occurs, other cells are killed in the process of the subsequent divisions, and only a few of them containing mutant DNA are preserved in the state of repression up to the end of life time. Disorders of homeostasis due to exhausted of physiological reserves - (natural or early aging) are manifested as a promoter. In that period the derepression of mutant DNA occurs and malignant growth of tumor starts.
Shvedov
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D000818:Animals; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000235:genetics; D004307:Dose-Response Relationship, Radiation; D005266:Femoral Neoplasms / Q000209:etiology* / Q000235:genetics; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000235:genetics; D011829:Radiation Dosage; D051381:Rats; D013326:Strontium Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*
D004273:DNA, Neoplasm; D013326:Strontium Radioisotopes
Skhematicheskaia model' osteosarkomogeneza, indutsirovannogo 90Sr.