Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia.
To study the effect of Platycodon grandiflorum (P.g.) feeding on serum and liver lipid concentrations, diet-induced hyperlipidemic rats were fed diets containing 5% and 10% P.g. powder for 3 weeks. The P.g. feeding markedly decreased both serum and liver lipid concentrations in hyperlipidemic rats. Especially, 5% P.g. diet significantly decreased the concentrations of total cholesterol and triglycerides in serum and liver as compared with those of the hyperlipidemic control group. Dietary P.g. also induced a reduction in low-density lipoprotein (LDL)-cholesterol as well as an increase in the concentration of high-density lipoprotein (HDL)-cholesterol in serum. Furthermore, the atherogenic index was also low in rats fed P.g. diet. These results indicated that dietary P.g. may have a beneficial effect on preventing hypercholesterolemia and hyperlipidemia.
Kim
K S
KS
Molecular Biomedicine Research Group, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Taejon, Korea.
Ezaki
O
O
Ikemoto
S
S
Itakura
H
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000032:analysis / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D004032:Diet / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism / Q000517:prevention & control; D006949:Hyperlipidemias / Q000209:etiology* / Q000378:metabolism* / Q000517:prevention & control; D007770:L-Lactate Dehydrogenase / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis* / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000032:analysis / Q000097:blood / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D008076:Cholesterol, HDL; D004365:Drugs, Chinese Herbal; D008055:Lipids; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase