title: Treatment of pituitary resistance to thyroid hormone (PRTH) in an 8-year-old boy.
abstract: We report on an 8-year-old boy with pituitary resistance to thyroid hormone (PRTH) having a cysteine for arginine substitution at codon 320 in the TR-beta gene who was presented because of thyrotoxicosis. Due to its suppressive effect on the pituitary thyrotropin secretion, treatment with D-thyroxine (D-T4) was started. After a few days, clinical euthyroidism was achieved but thyroid stimulating hormone secretion was not suppressed. Symptoms of thyrotoxicosis relapsed when therapy was interrupted so that therapy with D-T4 was reinstituted and continued to date. Symptoms did not recur, and the psychomotor development proceeded normally. D-T4 should therefore be considered in the treatment of thyrotoxicosis in PRTH.
authors.affiliation: Department of Paediatrics, University of Mainz, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Pohlenz
authors.forename: D
authors.initials: D
authors.lastname: Knöbl
mesh_terms: D000595:Amino Acid Sequence; D002648:Child; D003918:Dextrothyroxine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D018382:Thyroid Hormone Resistance Syndrome / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D013971:Thyrotoxicosis / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D003918:Dextrothyroxine