Protective effect of diethyldithiocarbamate on mercury-induced toxicity in kidney mitochondria.
The protective effect of diethyldithiocarbamate on several functions of kidney mitochondria, isolated from rats poisoned with mercury, was analyzed. The drug, administered at a concentration of 10 mg/ kg body weight to rats treated with a sublethal dose of Hg2+, for example, 2 mg/kg body weight, prevented the mercury-induced damage on: a) transmembrane potential, b) ATP synthesis, and c) Ca2+ accumulation. It is demonstrated that such a protective effect of diethyldithiocarbamate is due to its ionophoretic properties on mercury.
Reyes-Vivas
H
H
Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F., México.
Lopez-Moreno
F
F
Chávez
E
E
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002614:Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004050:Ditiocarb / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007668:Kidney / Q000648:ultrastructure*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D008564:Membrane Potentials / Q000187:drug effects; D008628:Mercury / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D002614:Chelating Agents; D000255:Adenosine Triphosphate; D004050:Ditiocarb; D008628:Mercury; D002118:Calcium