title: Langerhans' cells and L1 antigen expression in normal and abnormal squamous epithelium of the cervical transformation zone.
abstract: This study evaluates the presence of Langerhans' cells and expression of L1 antigen in squamous epithelium of the normal and dysplastic transformation zone of the cervix uteri and determines the influence of tobacco smoking and pregnancy. Women who smoked and pregnant women showed a decrease of Langerhans' cell counts in normal epithelium. In cervical intraepithelial neoplasia (CIN) 1 lesions, decreased Langerhans' cell counts were noted. L1 antigen expression was significantly less in CIN of all grades. Normal squamous epithelium of smokers showed weaker staining for L1 antigen but total staining scores were not significantly different. These data suggest a decrease in epithelial cell-mediated immune response in smokers, pregnant women and in low-grade CIN. Dysplastic squamous cells probably have intracellular regulatory problems independent of other immune cells.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital, St. Rafaël-Gasthuisberg, Leuven, Belgium.
authors.forename: W A
authors.initials: WA
authors.lastname: Poppe
authors.forename: M
authors.initials: M
authors.lastname: Drijkoningen
authors.forename: P S
authors.initials: PS
authors.lastname: Ide
authors.forename: J M
authors.initials: JM
authors.lastname: Lauweryns
authors.forename: F A
authors.initials: FA
authors.lastname: Van Assche
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000276:immunology / Q000473:pathology*; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000473:pathology*; D039841:Leukocyte L1 Antigen Complex; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000473:pathology; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D012907:Smoking / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*
chemical_list: D039841:Leukocyte L1 Antigen Complex; D019006:Neural Cell Adhesion Molecules