[The role of the HTLV-I virus in transformation of T lymphocytes].
HTLV-I virus is as etiological agent of adult T-cell leukemia (ATL). The virus encodes Tax regulatory protein, which induces malignant transformation of the T lymphocytes. Tax increases the expression of cell protooncogenes as well as lymphokines, among others IL-2 and its receptor. This protein induces autocrine proliferation of T lymphocytes, which is probably the main cause of their transformation. Tax represses the human beta-polymerase gene enzyme involved in host cell DNA repair, and then irreversible damage is effected in the T lymphocyte genome. Moreover, this regulatory protein cooperates with Rex phosphoprotein, stabilizing cell mRNA, which originate as the result of Tax protein activity. The regulatory proteins of HTLV-I virus influence the transcription of some cell genes and their products and in this way induce malignant transformation.
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Zakład Wirusologii Instytutu Mikrobiologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
D000328:Adult; D004260:DNA Repair; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology; D015458:Leukemia, T-Cell / Q000503:physiopathology / Q000821:virology*; D008213:Lymphocyte Activation / Q000502:physiology*; D008222:Lymphokines / Q000502:physiology; D014158:Transcription, Genetic
D007376:Interleukin-2; D008222:Lymphokines
Rola wirusa HTLV-I w transformacji limfocytów T.