[How to determine the best combination assay by several tumor markers?].
Combination assay by several tumor markers provides more precise diagnosis of malignancy than using a single tumor marker. The best combination assay by two tumor markers is determined as follows. MINIMIZE RFP (1-SpAorB(CA, CB)) + RFN(1-SnAorB(CA, CB)), where RFP, RFN denote the loss of false positive and false negative, respectively. SpAorB (CA, CB), SnAorB (CA, CB) are specificity and sensitivity of the combination assay by tumor markers A, B with cut-off values CA, CB.
Matsunaga
T
T
Division of Clinical Laboratory, Center for Adult Diseases, Osaka.
Kojima
J
J
Shimizu
T
T
Inoue
A
A
D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D015999:Multivariate Analysis; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor