A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence. age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision.
Morris
J Z
JZ
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA.
Tissenbaum
H A
HA
Ruvkun
G
G
D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D029742:Caenorhabditis elegans Proteins; D002874:Chromosome Mapping; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D008969:Molecular Sequence Data; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases; D010716:Phosphatidylinositols / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D010716:Phosphatidylinositols; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); C100662:AGE-1 protein, C elegans