Current concepts of B cell modulation.
Three interleukins with distinct functions, IL-4, IL-5 and IL-6, are involved in the regulation of B cell response into antibody producing cells. The studies with recombinant interleukins, however, demonstrated that the activities of these interleukins were not restricted to B lineage cells but showed a wide variety of biological functions on various tissues and cells. One of the most typical example of multifunctional interleukins is IL-6. It acts not only on B cells as B cell differentiation factor but also on T cells, hematopoietic stem cells, hepatocytes, nerve cells and myeloma cells. Deregulation of the expression of these interleukins was shown to be responsible for various diseases, such as i) IL-4 vs. immediate type hypersensitivity and ii) IL-6 vs. autoimmunity and multiple myelomas.
Matsuda
T
T
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Yamasaki
K
K
Taga
T
T
Hirano
T
T
Kishimoto
T
T
D000818:Animals; D000917:Antibody Formation; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology / Q000503:physiopathology; D015847:Interleukin-4 / Q000502:physiology*; D015848:Interleukin-5 / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology; D008211:Lymphocyte Cooperation / Q000502:physiology*; D051379:Mice; D018448:Models, Immunological; D005810:Multigene Family; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology; D010954:Plasmacytoma / Q000276:immunology / Q000473:pathology; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019947:Receptors, Interleukin-6; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D015848:Interleukin-5; D015850:Interleukin-6; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6; D015847:Interleukin-4