Involvement of IGF-II in human cancer.
IGF-II is a regulatory peptide which appears to be involved significantly in the progression of many tumors, while minimally involved in post-fetal non-tumor tissue. Interruption of IGF-II pathways therefore offers the possibility of tumor control with a high therapeutic index. Investigators should continue to evaluate tumors for the involvement of IGF-II as well as investigate clinically relevant means of disrupting those pathways.
Toretsky
J A
JA
Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Helman
L J
LJ
D002462:Cell Membrane / Q000378:metabolism; D018392:Genomic Imprinting; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D017527:Receptor, IGF Type 2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D018969:Insulin-Like Growth Factor Binding Proteins; D017527:Receptor, IGF Type 2; D007335:Insulin-Like Growth Factor II