title: Significance of lymphocytic sister chromatid exchange frequencies in ovarian cancer patients.
abstract: Very few studies report the analysis of sister chromatid exchanges in ovarian cancer patients. We tested the null hypothesis that SCE frequency increases with the advancing stages of ovarian cancer and follows a Poisson distribution. As controls we examined age- and sex-matched healthy volunteers who had no such past history. An increased average SCE frequency was observed in ovarian cancer patients (6.34 +/- 0.09) vis-à-vis controls (4.47 +/- 0.12). Further, the data also suggested a stage-wise increase in the SCE frequency.
authors.affiliation: Department of Anatomy, Kasturba Medical College, Manipal, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Dhar
authors.forename: S
authors.initials: S
authors.lastname: Devi
authors.forename: T R
authors.initials: TR
authors.lastname: Rao
authors.forename: U
authors.initials: U
authors.lastname: Kumari
authors.forename: A
authors.initials: A
authors.lastname: Joseph
authors.forename: M R
authors.initials: MR
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Nayak
authors.forename: Y
authors.initials: Y
authors.lastname: Shreemati
authors.forename: S M
authors.initials: SM
authors.lastname: Bhat
authors.forename: K R
authors.initials: KR
authors.lastname: Bhat
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D012854:Sister Chromatid Exchange