Prenatal paternity testing with deoxyribonucleic acid techniques.
OBJECTIVE
Our purpose was to determine the feasibility and optimal techniques for prenatal paternity testing.


METHODS
Since January 1989 we have offered prenatal paternity testing by deoxyribonucleic acid testing. We analyzed the ability to complete the testing and the time required to complete the testing and developed polymerase chain reaction-based tests to speed test results.


RESULTS
Before April 1990 only five of nine cases could be completed. Since that time 28 consecutive cases were successfully completed before delivery. Introduction of polymerase chain reaction-based testing has allowed us to perform testing on uncultured chorionic villi and to derive results within 3 weeks.


CONCLUSIONS
Analysis of uncultured chorionic villi allows prenatal paternity testing to be completed within the first trimester of pregnancy. Prenatal paternity testing can also be performed on cultured amniocytes and chorionic villi.
Strom
C M
CM
Reproductive Genetics Institute, Department of Obstetrics and Gynecology, Illinois Masonic Medical Center, Chicago, Illinois 60657, USA.
Rechitsky
S
S
Ginsberg
N
N
Verlinsky
O
O
Verlinsky
Y
Y
D000032:Abortion, Therapeutic; D001483:Base Sequence; D015139:Blotting, Southern; D002478:Cells, Cultured; D002824:Chorionic Villi / Q000737:chemistry*; D015193:Chorionic Villi Sampling; D004247:DNA / Q000032:analysis*; D015342:DNA Probes; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010334:Paternity; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011902:Rape
D015342:DNA Probes; D004247:DNA