Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection.
That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.
Johnson
L L
LL
Trudeau Institute, Inc., Saranac Lake, N.Y., USA.
Sayles
P C
PC
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014124:Toxoplasmosis, Animal / Q000276:immunology*
D007371:Interferon-gamma