title: Thrombogenic properties of untreated and poly(ethylene oxide)-modified polymeric matrices useful for preparing intraarterial ion-selective electrodes.
abstract: In vitro platelet adhesion studies are used to compare the thrombogenic properties of various polymer matrices useful for preparing implantable ion-selective membrane electrodes. Conventional plasticized poly(vinyl chloride) and alternate polyurethane materials (Tecoflex, Pellethane) doped with proton- (tridodecylamine) and potassium-selective (valinomycin) ionophores are shown to be potentially thrombogenic. Incorporation of high molecular weight block copolymers of poly(ethylene oxide) and poly(propylene oxide) (e.g., Pluronic F108 and Tetronic 1508) within ion-selective membranes reduces platelet adhesion. A more marked decrease in platelet adhesion is, however, observed when the Tecoflex-based membranes are coated with a thin photo-cross-linked layer of poly(ethylene oxide). Such surface-modified membranes are shown to retain potentiometric ion response properties (i.e., selectivity, response times, response slopes, etc.) essentially equivalent to untreated membranes.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor 48109, USA.
authors.forename: C
authors.initials: C
authors.lastname: Espadas-Torre
authors.forename: M E
authors.initials: ME
authors.lastname: Meyerhoff
mesh_terms: D000818:Animals; D017736:Ion-Selective Electrodes; D008567:Membranes, Artificial; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000009:adverse effects* / Q000737:chemistry; D011199:Potentiometry; D012756:Sheep
chemical_list: D008567:Membranes, Artificial; D011108:Polymers; D011092:Polyethylene Glycols