title: Pulmonary complications of HIV infection in Dar es Salaam, Tanzania. Role of bronchoscopy and bronchoalveolar lavage.
abstract: To determine the pulmonary complications in HIV-1-infected patients in Dar es Salaam, Tanzania, and to evaluate the diagnostic utility of bronchoscopy and bronchoalveolar lavage, we carried out a prospective study of 237 patients with acute respiratory disease who were hospitalized at Muhimbili Medical Center (MMC). Diagnoses were made using well-defined criteria. Of the total, 127 (54%) were HIV-1-seropositive and 110 (46%) were seronegative. Tuberculosis was the most common diagnosis occurring in 95 (75%) HIV-1-seropositive and 87 (79%) seronegative patients. Bacterial pneumonia was the next most common diagnosis occurring in 18 (14%) HIV-1-seropositive and 17 (15%) seronegative patients. Pneumocystis carinii pneumonia was diagnosed in one and Kaposi's sarcoma was seen in only two HIV-1-seropositive patients. Bronchoscopy with bronchoalveolar lavage was the sole source of a diagnosis in nine (8%) seropositive and six (5%) seronegative patients. We conclude that the HIV seroprevalence rate among patients hospitalized for acute respiratory disease at MMC is extremely high. Tuberculosis was the most common cause of pulmonary disease, regardless of HIV serostatus, and other HIV-associated opportunistic pulmonary infections were unusual. Bronchoscopy with bronchoalveolar lavage added little to the diagnosis and thus should not be high-priority procedures for the routine workup in resource-poor areas where tuberculosis is endemic.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California, San Francisco 94143-0841, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Daley
authors.forename: F
authors.initials: F
authors.lastname: Mugusi
authors.forename: L L
authors.initials: LL
authors.lastname: Chen
authors.forename: D M
authors.initials: DM
authors.lastname: Schmidt
authors.forename: P M
authors.initials: PM
authors.lastname: Small
authors.forename: E
authors.initials: E
authors.lastname: Bearer
authors.forename: E
authors.initials: E
authors.lastname: Aris
authors.forename: I M
authors.initials: IM
authors.lastname: Mtoni
authors.forename: J P
authors.initials: JP
authors.lastname: Cegielski
authors.forename: G
authors.initials: G
authors.lastname: Lallinger
authors.forename: I
authors.initials: I
authors.lastname: Mbaga
authors.forename: J F
authors.initials: JF
authors.lastname: Murray
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001992:Bronchoalveolar Lavage Fluid; D001999:Bronchoscopy; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications; D011446:Prospective Studies; D013636:Tanzania