An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death.
Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.
Afonso
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CL
Plum Island Animal Disease Center, Agriculture Research Service, U.S. Department of Agriculture, Greenport, New York 11944-0848, USA.
Neilan
J G
JG
Kutish
G F
GF
Rock
D L
DL
D000358:African Swine Fever Virus / Q000235:genetics / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D001483:Base Sequence; D002460:Cell Line; D002461:Cell Line, Transformed; D006801:Humans; D007377:Interleukin-3 / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000737:chemistry*; D019253:Proto-Oncogene Proteins c-bcl-2; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
C100339:5-HL protein, African swine fever virus; D007377:Interleukin-3; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014764:Viral Proteins