A comparison of miconazole, ketoconazole and fluconazole in their effects on temperature-dependent growth and thermal death in Candida albicans.
A strain of Candida albicans isolated from human sputum exhibited an associative temperature profile, with the initial maximum temperature = 42 degrees C, the final maximum temperature = 38 degrees C, and the minimum temperature of thermal death = 33 degrees C, showed a decrease in its cardinal temperatures and a reduction in the specific rates of growth and thermal death throughout the novel temperature ranges in the presence of either 25 microM of miconazole, ketoconazole or fluconazole. In the concentration range 0-30 microM, each drug concertedly depressed the kinetic and energetic parameters of growth, with lesser variation on the specific glucose transfer rate. The overall effect of miconazole was the greatest (up to one order of magnitude), while that of fluconazole was the least.
Madeira-Lopes
A
A
Laboratório de Microbiologia, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Miranda
J
J
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D013183:Sputum / Q000382:microbiology; D013696:Temperature
D000935:Antifungal Agents; D008825:Miconazole; D015725:Fluconazole; D007654:Ketoconazole