The P200 protein of Mycoplasma pneumoniae shows common features with the cytadherence-associated proteins HMW1 and HMW3.
The gene coding for the P200 protein of the bacterium, Mycoplasma pneumoniae (Mp), was cloned and sequenced. The sequence-derived data and biochemical data indicated that P200 has several features in common with the well characterized cytadherence-associated proteins, HMW1 and HMW3. These features consist of abnormal migration in SDS-PAGE, a central acidic domain with a high Pro content, repeated peptide blocks within the Pro-rich domain and P200 partitioning similar to HMW1 and HMW3 in the insoluble fraction after extraction of Mp with the detergent Triton X-100.
Proft
T
T
ZMBH, Mikrobiologie, Universität Heidelberg, Germany.
Hilbert
H
H
Plagens
H
H
Herrmann
R
R
D000595:Amino Acid Sequence; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D015815:Cell Adhesion Molecules; D003001:Cloning, Molecular; D005798:Genes, Bacterial / Q000235:genetics*; D018698:Glutamic Acid / Q000032:analysis; D007526:Isoelectric Point; D008565:Membrane Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009177:Mycoplasma pneumoniae / Q000737:chemistry / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D011392:Proline / Q000032:analysis
D001426:Bacterial Proteins; D015815:Cell Adhesion Molecules; C099979:HMW1 protein, Mycoplasma; C067481:HMW3 protein, Mycoplasma; D008565:Membrane Proteins; C099985:P200 protein, Mycoplasma pneumoniae; D018698:Glutamic Acid; D011392:Proline