[Correlation between an enzyme (glutathione S-transferase-pi) and effects of chemotherapy (cisplatin + etoposide)].
OBJECTIVE
We studied the correlation between cisplatin and etoposide chemotherapy and GST-pi staining in patients with untreated primary non-small cell lung cancer.


METHODS
Of patients diagnosed as having primary lung cancer, 27 patients (26 men, 1 woman; median age 74.9 years) with stage III b or over were studied. Histological types included squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. A course of treatment consisted of cisplatin 100 mg/m2/day x one day and etoposide 100 mg/m2/day x 3 days during 28 days. After 2 courses of treatment, the therapeutic effects were judged and examined in relation to immunostaining levels obtained with anti-GST-pi antibody.


RESULTS
Of patients with PR (14), 11 showed GST-pi (-) staining.


CONCLUSIONS
There is a correlation between GST-pi staining and the effects of cisplatin and etoposide chemotherapy.
Arai
T
T
Dept. of Internal Medicine, Gihoku General Hospital, Gifu, Japan.
Yasuda
Y
Y
Ito
Y
Y
Hayakawa
K
K
Takaya
T
T
Toshima
S
S
Shibuya
C
C
Nawada
M
M
Shibayama
M
M
Yoshimi
N
N
Ito
H
H
Fujiwara
H
H
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000201:enzymology; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling
D005047:Etoposide; D005982:Glutathione Transferase; D002945:Cisplatin