Disorders of platelet function.
Qualitative platelet disorders are described and reviewed above. The acquired platelet function defects are very common, and sometimes result in hemorrhage, especially in association with trauma or surgery. However, the specific biochemical defect is absent, and no characterized platelet abnormalities have been recognized. On the other hand, the hereditary qualitative platelet defects are rare, but the platelet abnormalities are characteristic. The study of these patients had led to an increased understanding of the normal primary hemostatic mechanism. Recently, the molecular basis analysis of the platelet defects has been developed. This will help us understand the molecular events involved in platelet adhesion and aggregation.
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First Department of Internal Medicine, Niigata University School of Medicine, Japan.
D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood; D001791:Blood Platelet Disorders / Q000097:blood / Q000145:classification / Q000209:etiology / Q000235:genetics / Q000276:immunology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001855:Bone Marrow Diseases / Q000097:blood / Q000150:complications; D006474:Hemorrhagic Disorders / Q000209:etiology / Q000628:therapy; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000150:complications; D009369:Neoplasms / Q000097:blood / Q000150:complications; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics / Q000276:immunology; D017713:Platelet Transfusion; D014511:Uremia / Q000097:blood / Q000150:complications
D016824:Antigens, Human Platelet; D010980:Platelet Membrane Glycoproteins