Antiandrogen. III. 11-oxapregnane steroids.
11-Oxachlormadinone acetate (17-acetoxy-6-chloro-11-oxapregna-4,6-diene-3,20-dione) and 2,11-dioxachlormadinone acetate (17-acetoxy-6-chloro-2,11-dioxapregna-4,6-diene-3,20-dione) were prepared as potential antiandrogenic agents. The effect of the latter compound on antiandrogenic activity when tested in the castrated rat was shown to be more potent than that of the parent compound, chlormadinone acetate.
Takegawa
S
S
Research Department, Teikoku Hormone Mfg. Co. Ltd., Kawasaki, Japan.
Koizumi
N
N
Mieda
M
M
Shibata
K
K
D000726:Androgen Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002715:Chlormadinone Acetate / Q000494:pharmacology; D005260:Female; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D011277:Pregnanediones / Q000138:chemical synthesis* / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology; D015430:Weight Gain / Q000187:drug effects
D000726:Androgen Antagonists; D011277:Pregnanediones; D002715:Chlormadinone Acetate; D013739:Testosterone