title: Pancreatic oncocytic endocrine tumors. Cytologic features of two cases.
abstract: BACKGROUND
  Oncocytoma designates a usually benign tumor consisting of oncocytes (cells rich in mitochondria). Rarely do endocrine pancreatic tumors show oncocytic transformation, and consequently their liver metastases may resemble a hepatocellular carcinoma.
  
  
  METHODS
  Case 1, a 36-year-old male, presented with an 8-cm pancreatic mass with multiple liver metastases. Fine needle aspiration (FNA) biopsy was performed on the liver. The cytologic features were highly cellular material; numerous isolated cells and irregular, loose cellular aggregates; rare mitoses; round or polygonal cell shape; rosette formation; and large, granular, eosinophilic cytoplasm (suggestive of poorly differentiated hepatocellular carcinoma). Case 2, a 57-year-old female with hypoglycemia, had a 13-cm pancreatic mass. FNA material showed the same cytologic features as case 1. In situ hybridization to detect albumin mRNA was negative in both cases, while immunocytologic reactions for glandular epithelial cytokeratin and chromogranin A were positive. Case 2 was also positive for insulin.
  
  
  CONCLUSIONS
  Oncocytic transformation in endocrine tumors of the pancreas is a rare occurrence and must be kept in mind in the diagnostic workup of FNA material from tumors of the hepatopancreatic region.
authors.affiliation: Department of Pathology, University of Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Pacchioni
authors.forename: M
authors.initials: M
authors.lastname: Papotti
authors.forename: L
authors.initials: L
authors.lastname: Macrì
authors.forename: G
authors.initials: G
authors.lastname: Forte
authors.forename: G
authors.initials: G
authors.lastname: Bussolati
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001707:Biopsy, Needle / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017403:In Situ Hybridization; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012333:RNA, Messenger / Q000032:analysis; D012709:Serum Albumin / Q000096:biosynthesis; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D012333:RNA, Messenger; D012709:Serum Albumin; D013004:Somatostatin