Bone marrow transplantation retinopathy in the absence of radiation therapy.
OBJECTIVE
To describe a case of bone marrow transplantation retinopathy in a patient in the absence of prior radiation therapy.


METHODS
Case report.


RESULTS
Bilateral scotomata developed in a 26-year-old woman because of a retinal microvasculopathy two years after receiving an autologous bone marrow transplantation for acute promyelocytic leukemia. No prior radiation therapy had been given.


CONCLUSIONS
Certain combinations of antimetabolites used during induction and transplantation may themselves be toxic to the retinal microvasculature. Patients who undergo bone marrow transplantation would benefit from regular and complete eye examinations, even in the absence of prior radiation therapy.
Cunningham
E T
ET
Francis I. Proctor Foundation, University of California Medical Center, San Francisco 94122, USA. emmett@itsa.ucsf.edu
Irvine
A R
AR
Rugo
H S
HS
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000628:therapy; D011878:Radiotherapy; D015356:Retinal Artery Occlusion / Q000209:etiology*; D012166:Retinal Hemorrhage / Q000209:etiology*; D012607:Scotoma / Q000209:etiology*; D014182:Transplantation, Autologous