Absence of Epstein-Barr viral encoded RNA (EBER) in primary cutaneous t-cell lymphoma.
Epstein-Barr virus (EBV) has been associated with various extracutaneous lymphoproliferative diseases and it has been suggested that EBV may have a similar aetiological role in cutaneous T-cell lymphoma. In this study, in situ hybridization was used to investigate the presence of EBV encoded RNAs (EBER-1 and EBER-2) in 37 biopsies from 28 cases of primary cutaneous T-cell lymphoma originating from the U.K. The results showed that EBV had no demonstrable pathogenic role in the lymphomas studied, as EBER was not detected in any case.
Angel
C A
CA
Department of Pathology, University of Sheffield Medical School, UK.
Slater
D N
DN
Royds
J A
JA
Nelson
S N
SN
Bleehen
S S
SS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008228:Lymphoma, Non-Hodgkin / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000821:virology; D012367:RNA, Viral / Q000302:isolation & purification*; D012878:Skin Neoplasms / Q000821:virology*
D012367:RNA, Viral