Gentamicin nephrotoxicity in humans and animals: some recent research.
It would appear from the literature cited in this article, that interest in gentamicin nephrotoxicity is still thriving. Despite extensive studies, the mechanism(s) of the nephrotoxicity is uncertain. Several clinical and experimental strategies have been employed in order to ameliorate or abolish the signs of gentamicin nephrotoxicity. Most of these were unsuccessful, impractical or unsafe. Therefore there is still a need for further studies to elucidate the mechanism(s) of action of the drugs nephrotoxicity, and to discover safe, practical and effective agents to ameliorate the nephrotoxicity in patients at risk.
Ali
B H
BH
Desert and Marine Environment Research Centre, United Arab Emirates University Al-Ain.
D000367:Age Factors; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D004032:Diet; D005260:Female; D005839:Gentamicins / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D017665:Hydroxyl Radical; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D051381:Rats; D012737:Sex Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D017665:Hydroxyl Radical