title: Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.
abstract: Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. liangt@bdg.niddk.nih.gov
authors.forename: T J
authors.initials: TJ
authors.lastname: Liang
authors.forename: A E
authors.initials: AE
authors.lastname: Reid
authors.forename: R
authors.initials: R
authors.lastname: Xavier
authors.forename: R D
authors.initials: RD
authors.lastname: Cardiff
authors.forename: T C
authors.initials: TC
authors.lastname: Wang
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D006965:Hyperplasia; D008321:Mammary Glands, Animal / Q000473:pathology*; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D019859:Proto-Oncogene Proteins c-met; D011519:Proto-Oncogenes; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases