title: Multiple keratoses and squamous carcinoma after PUVA treatment of vitiligo.
abstract: PUVA is known to be carcinogenic when used in the treatment of psoriasis. To date skin cancer has not been demonstrated after PUVA treatment of vitiligo. We report a patient in whom multiple squamous cell carcinomata and keratoses developed in vitiligo areas after a prolonged course of PUVA. PUVA therapy of vitiligo induces repigmentation of affected skin in some patients. An increased frequency of cutaneous neoplasms in depigmented areas is a potential hazard, as in these sites the photoprotective effect of melanin is lacking.
authors.affiliation: City of Dublin Skin and Cancer Hospital, Ireland.
authors.forename: D A
authors.initials: DA
authors.lastname: Buckley
authors.forename: S
authors.initials: S
authors.lastname: Rogers
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007642:Keratosis / Q000209:etiology*; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology*; D014820:Vitiligo / Q000188:drug therapy*