title: Large-dose intrathecal morphine for coronary artery bypass grafting.
abstract: Aggressive control of pain during the immediate postoperative period after cardiac surgery, associated with decreased blood catecholamine levels, may decrease morbidity and mortality. This study investigated the use of large-dose intrathecal morphine for cardiac surgery and its effect on postoperative analgesic requirements and blood catecholamine levels. Patients were randomized to receive either 4.0 mg of intrathecal morphine (Group MS) or intrathecal saline placebo (Group NS). Perioperative care was standardized and included postoperative patient-controlled analgesia. Arterial blood samples were obtained perioperatively to ascertain catecholamine levels. Patients in Group MS required significantly less postoperative intravenous morphine than patients in Group NS. Although perioperative norepinephrine and epinephrine levels in Group MS patients tended to be lower than Group NS patients, the differences were not statistically significant. In conclusion, large-dose intrathecal morphine initiates reliable postoperative analgesia but does not reliably attenuate the stress response during and after cardiac surgery.
authors.affiliation: Department of Anesthesiology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Chaney
authors.forename: K R
authors.initials: KR
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Barclay
authors.forename: S
authors.initials: S
authors.lastname: Slogoff
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia; D015360:Analgesia, Epidural; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D001026:Coronary Artery Bypass / Q000009:adverse effects; D004311:Double-Blind Method; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009638:Norepinephrine / Q000097:blood; D010149:Postoperative Pain / Q000517:prevention & control*; D010919:Placebos; D011446:Prospective Studies; D015203:Reproducibility of Results; D013312:Stress, Physiological / Q000517:prevention & control
chemical_list: D000701:Analgesics, Opioid; D010919:Placebos; D009020:Morphine; D009638:Norepinephrine; D004837:Epinephrine