title: Successful treatment of a primary cardiac leiomyosarcoma with ifosfamide and etoposide.
abstract: OBJECTIVE
  Primary cardiac leiomyosarcoma is a rare malignant tumor in childhood. Patients with unresectable or partially resected cardiac leiomyosarcoma typically have a poor prognosis. The role of chemotherapy in the treatment of these patients has not been well defined.
  
  
  METHODS
  A 6-week-old infant with an incompletely resected cardiac leiomyosarcoma was treated postoperatively with ifosfamide and etoposide.
  
  
  RESULTS
  The patient is disease-free and without apparent late effects 5 years following the completion of therapy.
  
  
  CONCLUSIONS
  The combination of ifosfamide and etoposide warrants further evaluation in patients with leiomyosarcoma.
authors.affiliation: Department of Pediatrics, Division of Hematology-Oncology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903-0019, USA.
authors.forename: P
authors.initials: P
authors.lastname: Han
authors.forename: R A
authors.initials: RA
authors.lastname: Drachtman
authors.forename: P
authors.initials: P
authors.lastname: Amenta
authors.forename: L J
authors.initials: LJ
authors.lastname: Ettinger
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006338:Heart Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery* / Q000648:ultrastructure; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery* / Q000648:ultrastructure; D015080:Mesna / Q000627:therapeutic use; D008854:Microscopy, Electron; D013997:Time Factors
chemical_list: D005047:Etoposide; D015080:Mesna; D007069:Ifosfamide