title: Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group.
abstract: The purpose of this study was to investigate the presence of any correlation between recurrent radicular pain during the first six months following first surgery for herniated lumbar intervertebral disc and the amount of lumbar peridural fibrosis as defined by MR imaging. 197 patients who underwent first-time single-level unilateral discectomy for lumbar disc herniation were evaluated in a randomized, double-blind, controlled multicenter clinical trial. Clinical assessments, performed by physicians blinded to patient treatment status, were conducted preoperatively and at one and six months postoperatively. The enhanced MR images of the operative site utilized in the analysis were obtained at six months postoperatively. Radicular pain was recorded by the patient using a validated visual analog pain scale in which 0 = no pain and 10 = excruciating pain. The data obtained at the 6 month time point were analyzed for an association between amount of peridural scars as measured by MR imaging and clinical failure as defined by the recurrence of radicular pain. The results showed that the probability of recurrent pain increases when scar score increases. Patients having extensive peridural scar were 3.2 times more likely to experience recurrent radicular pain than those patients with less extensive peridural scarring. In conclusion, this prospective, controlled, randomized, blinded, multicenter study has demonstrated that there is a significant association between the presence of extensive peridural scar and the occurrence of recurrent radicular pain.
authors.affiliation: Div. of Radiology, Cleveland Clinic Foundation, Ohio, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Ross
authors.forename: J T
authors.initials: JT
authors.lastname: Robertson
authors.forename: R C
authors.initials: RC
authors.lastname: Frederickson
authors.forename: J L
authors.initials: JL
authors.lastname: Petrie
authors.forename: N
authors.initials: N
authors.lastname: Obuchowski
authors.forename: M T
authors.initials: MT
authors.lastname: Modic
authors.forename: N
authors.initials: N
authors.lastname: deTribolet
mesh_terms: D000293:Adolescent; D000328:Adult; D002921:Cicatrix / Q000175:diagnosis* / Q000517:prevention & control; D017586:Diskectomy; D004311:Double-Blind Method; D004388:Dura Mater / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D005782:Gels; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000175:diagnosis / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011183:Postoperative Complications / Q000175:diagnosis* / Q000517:prevention & control; D011446:Prospective Studies; D011843:Radiculopathy / Q000175:diagnosis* / Q000517:prevention & control; D012008:Recurrence; D000267:Tissue Adhesions / Q000175:diagnosis / Q000517:prevention & control
chemical_list: D005782:Gels