title: Peptide modulation of allergen-specific immune responses.
abstract: In vitro peptide stimulation of allergen-reactive T-helper type 1 and type 0 cells, in the absence of costimulatory signals, induces anergy that is accompanied by the modulation of cell surface phenotype and changes in cytokine production. In experimental animal models, the administration of allergen-derived peptides may result in the downregulation of cytokine and antibody production, which is preceded by transient activation of CD4+ T cells, without the induction of effector immunity. Preliminary results of clinical trials using allergen-derived peptides for desensitization are becoming available and should provide some insight into the efficacy of peptide therapy in man.
authors.affiliation: Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: G F
authors.initials: GF
authors.lastname: Hoyne
authors.forename: N M
authors.initials: NM
authors.lastname: Kristensen
authors.forename: H
authors.initials: H
authors.lastname: Yssel
authors.forename: J R
authors.initials: JR
authors.lastname: Lamb
mesh_terms: D016525:Antigenic Modulation; D016207:Cytokines / Q000096:biosynthesis; D003888:Desensitization, Immunologic; D000939:Epitopes; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007108:Immune Tolerance; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines; D000939:Epitopes; D010455:Peptides