title: Resection of hepatocellular carcinoma in patients with cirrhosis.
abstract: Between 1987 and 1993, 53 hepatic resections for hepatocellular carcinoma (HCC) were performed in 51 patients with cirrhosis. Limited hepatic resection was performed in 66 per cent of patients. The postoperative mortality rate was 13 per cent. The tumours recurred in 27 patients (53 per cent), and the cumulative recurrence rate at 1 and 4 years was 41 and 89 per cent, respectively. Mean time to recurrence was 11.7 months and the most frequent site was the liver (21 patients). The only significant risk factor for recurrence was symptomatic tumours. The recurrence rate of HCC in patients with cirrhosis with surgical resection alone is high and actuarial survival at 4 years is very low. Other approaches to the treatment of HCC in patients with cirrhosis require consideration.
authors.affiliation: Department of Surgery, Hospital General Universitari Vall d'Hebron, Universidad Autonoma de Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Balsells
authors.forename: R
authors.initials: R
authors.lastname: Charco
authors.forename: J L
authors.initials: JL
authors.lastname: Lazaro
authors.forename: E
authors.initials: E
authors.lastname: Murio
authors.forename: V
authors.initials: V
authors.lastname: Vargas
authors.forename: E
authors.initials: E
authors.lastname: Allende
authors.forename: C
authors.initials: C
authors.lastname: Margarit
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome