title: Effects of hemodynamic changes on taurine release from posterior hypothalamus of freely moving rats.
abstract: OBJECTIVE
  To study the effects of blood volume and vascular resistance on taurine release.
  
  
  METHODS
  We used push-pull superfusion technique in the posterior hypothalamus of conscious freely moving rats. Taurine was determined in the superfusate by HPLC with fluorescence detection following automatic precolumn o-phthaldialdehyde (OPA) derivatization.
  
  
  RESULTS
  Hypervolemia increased the release of taurine in the hypothalamus. Intravenous infusion of levarterenol (3 micrograms kg-1 min-1) elicited a pronounced pressor response and an increase in the release of taurine. Conversely, a controlled hemorrhagic hypotension or iv infusion of nitroprusside (30 micrograms kg-1 min-1) elicited a hypotension and a decrease in the release of taurine from the posterior hypothalamus.
  
  
  CONCLUSIONS
  In the posterior hypothalamus, taurine might play an important role in central blood pressure regulation.
authors.affiliation: Institute of Pharmacology and Toxicology, Innsbruck University, Austria.
authors.forename: L J
authors.initials: LJ
authors.lastname: Guo
authors.forename: P
authors.initials: P
authors.lastname: Athineos
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D007034:Hypothalamus, Posterior / Q000378:metabolism*; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D013654:Taurine; D009638:Norepinephrine