Modification by muscimol of naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
1. In morphine-dependent mice, muscimol, a GABAA agonist when given i.p. 30 min before naloxone, attenuated the naloxone-precipitated withdrawal symptoms of jumping, "wet dog" shakes and burrowing, but not body weight loss. 2. Muscimol produced a hypothermic effect which was further aggravated by naloxone.
El-Kadi
A O
AO
Department of Pharmacology, Al-Arab Medical University, Benghazi, Libya.
Sharif
S I
SI
D000818:Animals; D018755:GABA Agonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009021:Morphine Dependence; D009118:Muscimol / Q000494:pharmacology*; D009270:Naloxone / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D009292:Narcotic Antagonists / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D018755:GABA Agonists; D009292:Narcotic Antagonists; D009118:Muscimol; D009270:Naloxone