Genetics of coxsackievirus B3 cardiovirulence.
The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent (able to cause disease). Here, we present preliminary data mapping the site in a coxsackievirus B3 genome which determines a cardiovirulent phenotype.
Tracy
S
S
Department of Pathology, University of Nebraska Medical Center, Omaha 68198, USA.
Tu
Z
Z
Chapman
N
N
Hufnagel
G
G
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000821:virology*; D003001:Cloning, Molecular; D003384:Coxsackievirus Infections / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D029822:Enterovirus B, Human / Q000235:genetics* / Q000472:pathogenicity; D016679:Genome, Viral; D006321:Heart / Q000821:virology*; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009205:Myocarditis / Q000473:pathology / Q000821:virology; D009206:Myocardium / Q000473:pathology; D010641:Phenotype; D014774:Virulence / Q000235:genetics
D004279:DNA, Viral