title: Marjolin's ulcer of the foot caused by nonburn trauma.
abstract: Marjolin's ulcers are malignancies that arise from previously traumatized, chronically inflamed, or scarred skin. We report a case of squamous cell carcinoma arising in a foot wound 42 years after the time of injury. The historical background, epidemiology, pathophysiology, diagnosis, treatment, and prognosis of Marjolin's ulcer are reviewed. Diagnosis is best accomplished by punch biopsy or excision of suggestive lesions. Wide local excision is required and amputation may be necessary to achieve an adequate margin. Regional lymph node dissection should be done if regional nodes are palpable. Elective lymph node dissection is controversial but should be considered if the tumor is poorly differentiated. Lymph node metastases and high tumor grade indicate a poor prognosis. Clinicians should be diligent in the long-term surveillance of all significant scars or areas of chronic inflammation.
authors.affiliation: Section of Surgical Oncology, Department of Surgery, University of Kentucky Chandler Medical Center, Lexington 40536-0084, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Hill
authors.forename: D A
authors.initials: DA
authors.lastname: Sloan
authors.forename: E Y
authors.initials: EY
authors.lastname: Lee
authors.forename: P C
authors.initials: PC
authors.lastname: McGrath
authors.forename: D E
authors.initials: DE
authors.lastname: Kenady
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D018409:Foot Injuries / Q000150:complications*; D016523:Foot Ulcer / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017169:Neoplasms, Post-Traumatic / Q000209:etiology*; D013997:Time Factors