[Expression of primitive stem cell antigens on the blast cells of patients with chronic myeloid leukemia].
The review presents the data available in the literature on an immunological phenotype of early precursors of human hemopoietic cells. Due to advances in hybrid technology, a great lot of monoclonal antibodies suitable for investigations of precursors of hemopoietic cells, including those of a stem cell have been designed. The review gives the basic characteristics of the antigens CD34, CD33, CD7, Thy-1, HLA-DR, and nonstrain-limited antigens expressed on the hemopoietic precursors and provides data on the expression of these antigens on the blast cells of patients with chronic myeloid leukemia (CML). It also discusses whether to identify immunological subvariants of the blast crisis of CML is expedient.
Baryshnikov
A Iu
AIu
D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis*; D018952:Antigens, CD34 / Q000032:analysis; D019011:Antigens, CD7 / Q000032:analysis; D001752:Blast Crisis / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000473:pathology*; D010641:Phenotype; D013234:Stem Cells / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34; D019011:Antigens, CD7; D006684:HLA-DR Antigens
Ekspressiia antigenov primitivnoĭ stvolovoĭ kletki na blastnykh kletkakh bol'nykh khronicheskim mieloidnym leĭkozom.