title: Phenotypic changes in Langerhans' cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?
abstract: The role of Langerhans cells (LC) in the initiation of an immune response to a viral infection remains unclear. In vivo epidermal infection with the arboviruses West Nile virus and Semliki Forest virus significantly increased the expression of major histocompatibility complex class II antigens, CD54, and CD80 on LC. Thus, during an epidermally acquired viral infection, local LC appear to mature to a phenotype approximating that of lymphoid dendritic cells. This change may be important in the activation of naïve T cells and the subsequent clearance of viral infection.
authors.affiliation: Department of Pathology, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Johnston
authors.forename: G M
authors.initials: GM
authors.lastname: Halliday
authors.forename: N J
authors.initials: NJ
authors.lastname: King
mesh_terms: D018354:Alphavirus Infections / Q000276:immunology; D000818:Animals; D001102:Arbovirus Infections / Q000276:immunology*; D001103:Arboviruses / Q000276:immunology*; D018122:B7-1 Antigen / Q000096:biosynthesis*; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D016130:Immunophenotyping; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D007801:Langerhans Cells / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012672:Semliki forest virus / Q000276:immunology; D014709:Vero Cells; D014901:West Nile Fever / Q000276:immunology; D014902:West Nile virus / Q000276:immunology
chemical_list: D018122:B7-1 Antigen; D018799:Intercellular Adhesion Molecule-1