Organochlorine compounds: Risk of non-Hodgkin's lymphoma and breast cancer?
Organochlorines (i.e., synthetic chlorinated hydrocarbon compounds) are widespread, environmental contaminants that are present throughout the United States. Strong epidemiological evidence has linked occupational exposure to a high incidence of non-Hodgkin's lymphoma. Recently, it has been postulated that exposure to organochlorines increases the risk of developing breast cancer. Human data on this issue remain insufficient, but recent results are very consistent. Observations in human populations of the immunotoxic and hormone-mimicking properties of some organochlorines add biological plausibility to the epidemiologic findings. Limitations in our ability to measure organochlorine exposure still preclude a quantitative risk assessment, relative to these cancer endpoints. Public health action with respect to restriction of ongoing production and use of organochlorines, however, appears warranted for purposes of prevention.
Hoffman
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School of Public Health-Graduate School, Department of Epidemiology, University of North Carolina at Chapel Hill, USA.
D001943:Breast Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000009:adverse effects*; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000453:epidemiology; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D016273:Occupational Exposure / Q000032:analysis; D012307:Risk Factors
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides