Successful treatment of a therapy-resistant severely pruritic skin eruption of malignancy-associated dermatomyositis with high-dose intravenous immunoglobulin.
Malignancy-associated dermatomyositis developing in a middle-aged Japanese female was successfully treated by removal of her gastric cancer. However, five years later, concomitant with catching a cold, her severely pruritic skin lesions recurred on exposed areas. Six years after the start of corticosteroid therapy for her annoying skin lesion, we started to treat her with high-dose intravenous immunoglobulin (IVIG) infusion therapy because of the difficulty of reducing the dosage of oral prednisone, that had secondarily induced adverse effects. After five courses of the therapy, her recalcitrant, pruritic, erythematous skin lesions improved dramatically, enabling a satisfactory reduction in the dosage of oral prednisone. There were no significant adverse side effects with IVIG.
Kikuchi-Numagami
K
K
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Sato
M
M
Tagami
H
H
D003882:Dermatomyositis / Q000209:etiology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011537:Pruritus / Q000209:etiology / Q000628:therapy*; D013274:Stomach Neoplasms / Q000150:complications*
D016756:Immunoglobulins, Intravenous; D011241:Prednisone