Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid.
The effect of n-6 fatty acids, particularly gamma-linolenic acid (GLA), on the oxidase response and neutrophil priming by tumour necrosis factor alpha and interleukin 8 was studied in both normal volunteers and patients with obstructive jaundice. GLA inhibited the neutrophil respiratory burst at concentrations higher than 50 mummol/l, but abolished cytokine priming at concentrations as low as 1 mummol/l. Inhibition was not the result of either cytotoxicity to the neutrophils or alteration in cytosolic free calcium homoeostasis. It is concluded that GLA is a potential inhibitor of neutrophil priming by cytokines and of the oxidative response.
Jiang
W G
WG
University Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
Puntis
M C
MC
Horrobin
D F
DF
Scott
C
C
Hallett
M B
MB
D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000378:metabolism; D002779:Cholestasis / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D016897:Respiratory Burst / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D017965:gamma-Linolenic Acid / Q000494:pharmacology*
D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D017965:gamma-Linolenic Acid; D002118:Calcium