title: Effect of transdermal hyoscine on nausea and vomiting during and after middle ear surgery under local anaesthesia.
abstract: The efficacy of transdermal hyoscine in the reduction of nausea, retching and vomiting was compared with placebo during and after stapedo- and tympanoplasty under local anaesthesia in a double-blind, prospective and randomized study. In the placebo group (n = 29), 69% of the patients were free from emetic symptoms during and 41% after the operation. The corresponding figures were 93% (P < 0.05) and 74% (P < 0.05) in the hyoscine group (n = 27). The patients in the placebo group needed more droperidol during and after operation (P < 0.05). The frequency of side effects was similar in both groups. In posturography the patients with emetic sequelae in the placebo group had a markedly deteriorated upkeep of posture (P < 0.05) measured as body sway velocities. A strong correlation was found between motion sickness and emetic sequelae after surgery, and patients with a history of motion sickness benefited most from hyoscine.
authors.affiliation: Department of Anaesthesia, Otolaryngological Hospital, University of Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Honkavaara
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000772:Anesthesia, Local; D000932:Antiemetics / Q000008:administration & dosage*; D004311:Double-Blind Method; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011187:Posture; D011446:Prospective Studies; D012601:Scopolamine / Q000008:administration & dosage*; D013201:Stapes Surgery; D014433:Tympanoplasty; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D012601:Scopolamine