Selected histochemical and immunocytochemical markers of biological activity of brain blood vessels.
In the review dyes, enzymes and molecules were described, which serve as markers of various functions of blood vessels or their structural elements. From among histochemically revealed enzymes those were described which are of significance in the characteristics of the blood-brain barrier function. Attention has been paid to dyes with which pathology in blood vessel wall can be visualized. Among molecules, mainly adhesion and markers of angiogenesis were described. Their discovery is possible with the use of antibodies in immunohistochemical methods taking into account the accessibility to antibodies and their usefulness in the recognition of pathophysiological processes in the central nervous system.
Kałuza
J
J
Department of Neuropathology, Institute of Neurology, Collegium Medicum, Jagiellonian University, Kraków.
D015415:Biomarkers / Q000032:analysis; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000201:enzymology; D002536:Cerebral Arteries / Q000473:pathology; D002550:Cerebral Veins / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009389:Neovascularization, Pathologic / Q000473:pathology; D019006:Neural Cell Adhesion Molecules / Q000032:analysis
D015415:Biomarkers; D019006:Neural Cell Adhesion Molecules