title: Multilobated B cell lymphoma (Pinkus variant) with isolated muscular localization in a patient with systemic sclerosis: a case report.
abstract: The association of systemic sclerosis (SSc) and non-Hodgkin's lymphoma (NHL) is a rare event whose pathogenesis remains to be clarified. We describe a case of NHL in a patient with SSc, in whom the NHL was particular in terms of clinical presentation (primitive muscle and bone involvement) and histologic type (large multilobated B-cell variant). The lymphoma was clinically aggressive but responded well to therapy. Surveillance for the development of "atypical" NHL is suggested in SSc cases.
authors.affiliation: Servizio Autonomo di Ematologia Diagnostica, Istituto di Scienze Mediche dell' Università degli Studi, Ospedale Maggiore IRCCS, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Parma
authors.forename: G
authors.initials: G
authors.lastname: Sita
authors.forename: A
authors.initials: A
authors.lastname: Guffanti
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
authors.forename: M
authors.initials: M
authors.lastname: Colombi
authors.forename: L
authors.initials: L
authors.lastname: Baldini
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000473:pathology*; D008297:Male; D009132:Muscles / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications / Q000473:pathology*