Leukocyte adhesion deficiency: report of a case and review of the literature.
Leukocyte adhesion deficiency (LAD) is a rare inherited immunodeficiency that is characterized by deficiency of the beta 2 integrin leukocyte adhesion molecules Mac-1, LFA-1, and p150,95. We describe a case of the severe form of LAD in an infant with recurrent infections and with a complete deficiency of beta 2 integrin molecules, and review the clinical aspects of the syndrome.
Lipnick
R N
RN
Department of Pediatrics, Fairfax Hospital for Children, Falls Church, Virginia, USA.
Iliopoulos
A
A
Salata
K
K
Hershey
J
J
Melnick
D
D
Tsokos
G C
GC
D018821:CD18 Antigens / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D010375:Pedigree
D018821:CD18 Antigens; D015815:Cell Adhesion Molecules