[Case of adult T-cell leukemia without antibodies for HTLV-I but with for pX gene region].
A 76-year-old woman had lymphocytosis with lymphocytes having convoluted or lobulated nuclei. These abnormal lymphocytes (leukemic cells) were positive for CD4, and some expressed IL-2R (CD25) and CD3 molecules, respectively. These morphologic and phenotypic features were compatible with adult T-cell leukemia, but serum antibodies to human T-cell lymphotropic virus type I (HTLV-I) were not detected by the particle aggregation method and an enzyme-linked immunosorbent assay. The polymerase chain reaction showed that the LTR, gag, pol, and env regions of HTLV-I proviral DNA had not been incorporated into the leukemic cells. Only the pX region was detected in these leukemic cells.
Takenaka
T
T
Department of Laboratory Medicine, Wakayama Medical School, Japan.
Kuribayashi
K
K
Tsukiyama
M
M
Nakamine
H
H
Konami
S
S
Okada
K
K
D000368:Aged; D001483:Base Sequence; D015704:CD4 Antigens / Q000032:analysis; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D005814:Genes, Viral; D016355:Genes, pX; D015481:HTLV-I Antibodies; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D015458:Leukemia, T-Cell / Q000821:virology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D015704:CD4 Antigens; D004279:DNA, Viral; D015481:HTLV-I Antibodies