DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.
Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa including two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell-mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloantigen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.
Shibuya
A
A
DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, California 94304-1104, USA.
Campbell
D
D
Hannum
C
C
Yssel
H
H
Franz-Bacon
K
K
McClanahan
T
T
Kitamura
T
T
Nicholl
J
J
Sutherland
G R
GR
Lanier
L L
LL
Phillips
J H
JH
D000595:Amino Acid Sequence; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000097:blood / Q000276:immunology / Q000302:isolation & purification; D001402:B-Lymphocytes / Q000737:chemistry; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic; D018076:DNA, Complementary / Q000302:isolation & purification; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008222:Lymphokines / Q000378:metabolism; D008565:Membrane Proteins / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008969:Molecular Sequence Data; D009000:Monocytes / Q000737:chemistry; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D000098862:T Lineage-Specific Activation Antigen 1
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D000098862:T Lineage-Specific Activation Antigen 1; D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D000939:Epitopes; D008222:Lymphokines; D008565:Membrane Proteins