Bladder cancer producing granulocyte colony-stimulating factor: a case report.
A rare case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 63-year-old man with a progressive, grade 3 transitional cell bladder carcinoma, showed marked leukocytosis (maximum 181,800/mm3) and an elevated serum G-CSF to 131.7 pg/mL. After radical cystectomy and neoadjuvant chemotherapy, the tumor recurred locally. Immunohistochemical examination with monoclonal antibody specific for G-CSF revealed positive staining in the local recurrent tumor. To our knowledge, there have been only seven cases reported of bladder cancer producing G-CSF.
Nishimura
K
K
Department of Urology, Minoh City Hospital, Japan.
Higashino
M
M
Hara
T
T
Oka
T
T
D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000378:metabolism*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000378:metabolism*
D016179:Granulocyte Colony-Stimulating Factor