Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Laurén, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters.
Sier
C F
CF
Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
Kubben
F J
FJ
Ganesh
S
S
Heerding
M M
MM
Griffioen
G
G
Hanemaaijer
R
R
van Krieken
J H
JH
Lamers
C B
CB
Verspaget
H W
HW
D000368:Aged; D017364:Collagenases / Q000032:analysis*; D005260:Female; D018093:Gelatinases / Q000032:analysis*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000032:analysis*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality; D015996:Survival Rate
D017364:Collagenases; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9