Intrafamilial and case-control association analysis of D2S152 in insulin-dependent diabetes.
We have performed intrafamilial and case-control association studies to examine the previously reported linkage disequilibrium between D2S152 and a type 1 diabetes susceptibility gene on chromosome 2q31-q33 (IDDM7). Significant linkage disequilibrium was observed in our subset of 47 Florida affected sibpair families (p < 0.02) but not in the other 57 USA families. We were not able to detect any significant associations between IDDM and D2S152 using case-control studies in a Caucasian data set of 270 unrelated diabetic patients and 370 normal controls ascertained from Florida, or in a Chinese data set of 90 patients and 169 normal controls. Our results suggest that linkage disequilibrium between IDDM7 and D2S152 must be very loose.
Luo
D F
DF
Department of Pathology and Laboratory Medicine, University of Florida, Gainesville 32610, USA.
Maclaren
N K
NK
Huang
H S
HS
Muir
A
A
She
J X
JX
D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D010375:Pedigree; D013624:Taiwan / Q000208:ethnology
D005819:Genetic Markers