title: Systemic oxidative stress and its relationship with age and illness. Associazione Medica "Sabin".
abstract: OBJECTIVE
  It has recently been proposed that increased oxidative stress may play a role in the aging process and age-associated degenerative diseases.
  
  
  METHODS
  A cross-sectional study was carried out to assess the relationship of circulating antioxidants, namely vitamins E and C, beta-carotene, proteic thiols (P-SH) and ceruloplasmin, and of lipid peroxides, with both aging and aging with disability, i.e., unsuccessful aging.
  
  
  METHODS
  One hundred healthy free living and 62 disabled octo-nonagenarians and 91 healthy adults were enrolled in the study.
  
  
  RESULTS
  Free living and disabled older adults had lower antioxidant and higher lipid peroxide levels than healthy adults, as well as the disabled older adults compared with free living older persons. Using logistic regression, we observed that plasma concentrations of vitamins E and C, P-SH, and lipid peroxides were independently associated with either aging or aging with disability, apparently representing biochemical indicators of patient status. In particular, aging and unsuccessful aging were associated with higher levels of lipid peroxides independently of circulating levels of vitamins C and E, suggesting that the increased oxidative stress was not merely an effect of a lower dietary intake of antioxidants. Serum ceruloplasmin was significantly higher in free living older adults than in healthy adults, and in the disabled compared with free living octo-nonagenarians.
  
  
  CONCLUSIONS
  Our findings are consistent with the presence of systemic oxidant load in older adults, and this phenomenon is far more evident in unsuccessful aging.
authors.affiliation: Centro per lo Studio e la Terapia dell'Arteriosclerosi, Institute of Medical Physiopathology, Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mezzetti
authors.forename: D
authors.initials: D
authors.lastname: Lapenna
authors.forename: F
authors.initials: F
authors.lastname: Romano
authors.forename: F
authors.initials: F
authors.lastname: Costantini
authors.forename: S D
authors.initials: SD
authors.lastname: Pierdomenico
authors.forename: D
authors.initials: D
authors.lastname: De Cesare
authors.forename: F
authors.initials: F
authors.lastname: Cuccurullo
authors.forename: G
authors.initials: G
authors.lastname: Riario-Sforza
authors.forename: G
authors.initials: G
authors.lastname: Zuliani
authors.forename: R
authors.initials: R
authors.lastname: Fellin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000032:analysis* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008054:Lipid Peroxides; D002570:Ceruloplasmin