title: [The "dose-response" mechanism of tumorigenesis in workers of radiochemical plants].
abstract: The "dose-response" mechanism has been studied for three main histological types of tumor in a cohort of 500 workers occupationally exposed to different doses of radiation (162 patients with lung cancer and 338 practically healthy persons) using the "case-control" method and multifactorial logic regression procedure. A non-linear threshold dependence was established for incorporated plutonium, with the threshold being at 8 kBq to correspond to 80 kGy. This relationship has been particularly distinct in cases of adenocarcinoma. No significant results have been obtained for the "dose-response" relationship in chronic external exposure to gamma irradiation. Said dependence for tobacco smoking appeared to be linear. Most pronounced variations were recorded for squamous cell carcinoma.
authors.forename: Z B
authors.initials: ZB
authors.lastname: Tokarskaia
authors.forename: N D
authors.initials: ND
authors.lastname: Okladnikova
authors.forename: Z D
authors.initials: ZD
authors.lastname: Beliaeva
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure; D011005:Plutonium / Q000009:adverse effects*
chemical_list: D011005:Plutonium
vernacular_title: Zavisimosti doza-otvet pri razvitii raka lëgkogo u rabotnikov radiokhimicheskogo proizvodstva.