title: L-735,334, a novel sesquiterpenoid potassium channel-agonist from Trichoderma virens.
abstract: A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based liquid medium. Its structure was determined on the basis of ms and nmr analysis. It retains distinct biological activity on the high conductance calcium-activated potassium channel, unlike its analogues 14-hydroxy CAF-603, CAF-603 3-oleate, or CAF-603 3-linoleate.
authors.affiliation: Department of Natural Products Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: O D
authors.initials: OD
authors.lastname: Hensens
authors.forename: G L
authors.initials: GL
authors.lastname: Helms
authors.forename: J M
authors.initials: JM
authors.lastname: Liesch
authors.forename: D L
authors.initials: DL
authors.lastname: Zink
authors.forename: R A
authors.initials: RA
authors.lastname: Giacobbe
authors.forename: G F
authors.initials: GF
authors.lastname: Bills
authors.forename: S
authors.initials: S
authors.lastname: Stevens-Miles
authors.forename: M L
authors.initials: ML
authors.lastname: Garcia
authors.forename: W A
authors.initials: WA
authors.lastname: Schmalhofer
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D002417:Cattle; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000819:agonists* / Q000187:drug effects; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014242:Trichoderma / Q000737:chemistry*
chemical_list: C100473:L 735334; D015221:Potassium Channels; D012717:Sesquiterpenes; D002118:Calcium