title: [Estimation of effectiveness of antiemetic treatment with Zofran given in one dose to children with neoplasms].
abstract: Clinical studies of antiemetic treatment with Zofran in children suffering from neoplastic diseases are presented. The studies were carried out in 33 children aged 3 months to 17 years treated in 1993. The majority of the patients were treated for ALL (20), Hodgkins disease (3), nephroblastoma (3), non-Hodgkin lymphoma (2), solid tumors (5). Two-hundred thirty-eight cycles of chemotherapy with cystostatics having varied emetic effects were carried out in these children. Zofran was given in one dose, one hour before chemotherapy in a dose of 4 or 8 mg. The intensity of vomiting was assessed according to the WHO 5-grade scale. O to 1 grade of vomiting was observed in 84.4%, 2nd grade in 15.2%. There were no cases of 3rd or 4th grade vomiting. No side-effects of the medication were observed in the studied group. It was found that Zofran is an effective and well-tolerated antiemetic medication in children on chemotherapy.
authors.affiliation: Katedra i Klinika Chorób Dzieci Akademii Medycznej w Bydgoszczy.
authors.forename: A
authors.initials: A
authors.lastname: Kurylak
authors.forename: D
authors.initials: D
authors.lastname: Kurylak
authors.forename: E
authors.initials: E
authors.lastname: Masłowska
authors.forename: A
authors.initials: A
authors.lastname: Gałaj
authors.forename: I
authors.initials: I
authors.lastname: Zawadzka
mesh_terms: D000293:Adolescent; D000932:Antiemetics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications*; D017294:Ondansetron / Q000627:therapeutic use*; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000932:Antiemetics; D017294:Ondansetron
vernacular_title: Ocena skuteczności leczenia przeciwwymiotnego Zofranem podawanym w jednorazowej dawce dziennej dzieciom z choroba nowotworowa.