title: Sevoflurane-nitrous oxide or halothane-nitrous oxide for paediatric bronchoscopy and gastroscopy.
abstract: We have studied 120 infants and children, in three age groups (3-11 months, 1-5 yr and 6-15 yr), to compare anaesthesia with sevoflurane or halothane for bronchoscopy or gastroscopy, or both. Premedication or i.v. anaesthetic agents were not used. Patients were allocated randomly to receive either 7% sevoflurane or 3% halothane in 66% nitrous oxide in oxygen for induction of anaesthesia. The same inspired mixture was continued during bronchoscopy while the concentration of the inhalation agent was reduced by 50% during gastroscopy. Induction times were shorter for infants than for children and shorter for sevoflurane than for halothane. Cardiac arrhythmias were significantly more frequent during halothane than during sevoflurane anaesthesia. Physiological and psychomotor recovery were more rapid after sevoflurane than after halothane. At 24-h follow-up, children who received sevoflurane had significantly less nausea and vomiting. We conclude that sevoflurane was superior to halothane for paediatric bronchoscopy and gastroscopy.
authors.affiliation: Department of Anaesthesiology, Children's Hospital University of Helsinki, Finland.
authors.forename: O A
authors.initials: OA
authors.lastname: Meretoja
authors.forename: T
authors.initials: T
authors.lastname: Taivainen
authors.forename: L
authors.initials: L
authors.lastname: Räihä
authors.forename: R
authors.initials: R
authors.lastname: Korpela
authors.forename: K
authors.initials: K
authors.lastname: Wirtavuori
mesh_terms: D000293:Adolescent; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001999:Bronchoscopy; D002648:Child; D002675:Child, Preschool; D004987:Ethers / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D006221:Halothane / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D008738:Methyl Ethers; D009609:Nitrous Oxide; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D009609:Nitrous Oxide; D006221:Halothane