Malignant hyperthermia during epidural anesthesia.
We anesthesized a patient susceptible to malignant hyperthermia (MH) three different times by epidural anesthesia with different types of local anesthetics. His skinned fiber test showed a marked acceleration of calcium (Ca2+)-induced Ca2+ release (CICR). When ester type local anesthetic was used for ankle contracture repair, MH signs appeared following the release of the tourniquet. CICR test is reliable for diagnosing different types of MH.
Motegi
Y
Y
Department of Anesthesiology, Kitasato University School of Medicine, Kanagawa, Japan.
Shirai
M
M
Arai
M
M
Kato
S
S
Kawana
Y
Y
Goto
F
F
D000293:Adolescent; D000767:Anesthesia, Epidural / Q000009:adverse effects*; D000842:Ankle / Q000601:surgery; D002118:Calcium / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008305:Malignant Hyperthermia / Q000503:physiopathology*; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D013710:Tendons / Q000601:surgery
D002118:Calcium