title: [Preoperative risk assessment of children with Duchenne muscular dystrophy and relevance for anesthesia and intra- and postoperative course].
abstract: BACKGROUND
  Patients suffering from muscle disorders have an elevated anesthetic risk, i.e. to develop malignant hyperthermia or rhabdomyolysis. In addition serious cardial and pulmonal complications are imminent during anesthesia for surgery.
  
  
  METHODS
  We investigated retrospectively the preoperative risk factors of 81 Duchenne patients undergoing 101 anesthesia (79 for muscle releasement operations and 23 for spine surgery) and the relation to possible complications due to the anesthesia and the intra- and postoperative course.
  
  
  CONCLUSIONS
  83% of the patients showed pathologic ECG, 26% cardiac insufficiency in echocardiography, 31% pathologic X-rays of the thorax and 73% serious pulmonary restriction. Consequently avoiding of anesthetic agents with a high trigger potential for developing malignant hyperthermia (i.e. halothane or muscle relaxants type succinylcholine) prevented severest complications as malignant hyperthermia, rhabdomyolysis or cardiac arrest. Nevertheless other complications (i.e. arrhythmia, cardiac insufficiency) occurred due to the cardiac and pulmonary limitations more pronounced in the older patients of the spine surgery group.
authors.affiliation: Abteilung Anästhesiologie/Intensivmedizin, Rehabilitationskrankenhaus, Orthopädische und Neurologische Klinik der Universität Ulm.
authors.forename: K H
authors.initials: KH
authors.lastname: Wollinsky
authors.forename: C
authors.initials: C
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Gelowicz-Maurer
authors.forename: P
authors.initials: P
authors.lastname: Geiger
authors.forename: H H
authors.initials: HH
authors.lastname: Mehrkens
authors.forename: T
authors.initials: T
authors.lastname: Naumann
mesh_terms: D000768:Anesthesia, General; D002648:Child; D000075202:Contraindications; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008305:Malignant Hyperthermia / Q000235:genetics / Q000517:prevention & control*; D016343:Monitoring, Intraoperative; D009136:Muscular Dystrophies / Q000235:genetics / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D012131:Respiratory Insufficiency / Q000235:genetics / Q000517:prevention & control*; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000235:genetics / Q000517:prevention & control*; D012307:Risk Factors
vernacular_title: Präoperative Risikoerfassung bei Kindern mit Muskeldystrophie Typ Duchenne und ihre Relevanz für die Anästhesie sowie den intra- und postoperativen Verlauf.