[The morphometric characteristics of the immune system organs in dynamic experimental Salmonella infection].
Quantitative and morphological changes in the immune system (CBA x C57BL/6)F1 mice after their enteral (group 1) and intraperitoneal (group 2) inoculation with Salmonella typhimurium in a dose of 2 x (10)6 microbial cells per mouse were studied. The study revealed that on day 28 after inoculation the death rate of the animals was 12.5 +/- 6.75% in group 1 and 57.84 +/- 4.89% in group 2. The same type of changes in the organs of the immune system was observed in both groups of mice, but in the animals of group 2 these changes were more pronounced. This was manifested by leukocytosis, exhaustion of thymic cells, hyperplasia, hypertrophy of the spleen and an increase in the proliferative activity in its B-zone, a decrease in the number of myelokaryocytes. Such changes are indicative of their importance in the resistance of the body to Salmonella infection.
Smoliagin
A I
AI
Chaĭnikova
I N
IN
Shevliuk
N N
NN
Anisimova
T M
TM
Byval'tseva
E V
EV
Varlamov
A N
AN
D000818:Animals; D005260:Female; D007107:Immune System / Q000276:immunology / Q000473:pathology*; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012481:Salmonella Infections, Animal / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D012486:Salmonella typhimurium; D013997:Time Factors
Morfometricheskaia kharakteristika organov immunnoĭ sistemy pri éksperimental'noĭ sal'monelleznoĭ infektsii v dinamike.