[Clinical significance of soluble interleukin-2 receptor levels in the cerebrospinal fluid in patients with adult T-cell leukemia complicated with meningeal infiltration].
We measured soluble interleukin-2 receptor (sIL-2R) levels in the cerebrospinal fluid (CSF) of patients with hematological malignancies especially, adult T-cell leukemia (ATL) and non-Hodgkin's lymphoma (NHL) with or without meningeal infiltration. CSF levels of sIL-2R were significantly higher in patients with ATL and NHL with meningeal infiltration than in patients with both diseases without meningeal infiltration. The sIL-2R levels in CSF were elevated in 4/4 ATL patients (100%) and 3/13 NHL patients (23%) with meningeal infiltration. CSF levels of sIL-2R from ATL patients with meningeal infiltration had a tendency to elevate in correlation with numbers of mononuclear cells and lactic dehydrogenase (LDH) in CSF. However, these had no correlation with serum levels of sIL-2R. Therefore, sIL-2 levels in CSF may be useful in the diagnosis of meningeal infiltration in patients with ATL, are probably specific markers for meningeal infiltration of ATL.
Tanaka
K
K
First Dept. of Internal Medicine, Kurume University School of Medicine, Japan.
Shiraishi
K
K
Sakamoto
A
A
Okubo
Y
Y
Fukuda
Y
Y
Fukahori
S
S
Jojima
H
H
Osabe
S
S
Honda
J
J
Natori
H
H
Oizumi
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D015470:Leukemia, Myeloid, Acute / Q000134:cerebrospinal fluid / Q000473:pathology; D015458:Leukemia, T-Cell / Q000134:cerebrospinal fluid* / Q000473:pathology*; D017254:Leukemic Infiltration; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid / Q000473:pathology; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2; D007770:L-Lactate Dehydrogenase