title: FDG-PET screening for cerebral metastases in patients with suspected malignancy.
abstract: 2-(18)F-Fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is increasingly being used in the evaluation of patients with malignancy. Recently, imaging protocols have incorporated ¿whole-body' views acquired over multiple steps. However, with this strategy, brain metastases can potentially go undetected. The aim of this study was to determine whether a supplementary 10-min brain 18F-FDG scan provides additional clinically useful information. Accordingly, we reviewed the studies of 273 patients with various malignancies in whom both whole-body and brain images were performed. Whole-body and regional attenuation-corrected 18F-FDG images were obtained approximately 60 min post-injection. A separate 10-min scan of the brain was subsequently performed. All studies were performed using a standard PET scanner with the images being interpreted by consensus of at least two experienced observers. Altogether, 119 studies were reported as normal (n = 96) or showing anatomic or normal variants (n = 23). Abnormalities involving extracranial organs were identified in 149 (55%) patients. Cerebral metastases were reported in 4 (1.5%) patients, only two of which (0.7%) were unsuspected prior to the PET scan. Incidental pathology (encephalopathy, infarct) was reported but unconfirmed in two further patients (0.7%). We conclude that routine ¿screening' for cerebral metastases in patients with suspected malignancy has a low yield and may not be clinically useful.
authors.affiliation: Clinical PET Centre, Guy's Hospital, UMDS, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Larcos
authors.forename: M N
authors.initials: MN
authors.lastname: Maisey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002648:Child; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008223:Lymphoma / Q000000981:diagnostic imaging; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000556:secondary; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000556:secondary; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose