A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid.
The concentration of (R)-N-methylsalsolinol, which is a dopamine-derived neurotoxin selective to dopamine neurons and induces parkinsonism in rats, was found to be increased significantly in the cerebrospinal fluid of untreated patients with Parkinson's disease. The enantio-specific occurrence of (R)-N-methylsalsolinol in cerebrospinal fluid suggests its enzymatic synthesis in the human brain. The individual differences in the activities of the enzymes determining the metabolism of (R)-N-methylsalsolinol in the brain might be involved in the pathogenesis of Parkinson's disease.
Maruyama
W
W
Department of Neurology, Nagoya University School of Medicine, Japan.
Abe
T
T
Tohgi
H
H
Dostert
P
P
Naoi
M
M
D000368:Aged; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D009498:Neurotoxins / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D051381:Rats; D012490:Salsoline Alkaloids / Q000134:cerebrospinal fluid* / Q000378:metabolism; D044005:Tetrahydroisoquinolines
D009498:Neurotoxins; D012490:Salsoline Alkaloids; D044005:Tetrahydroisoquinolines; C032837:salsoline; D004298:Dopamine; D006719:Homovanillic Acid