title: Different adhesion types and active sensitivity of platelet subpopulations.
abstract: Two different adhesion patterns of blood platelets with different sensitivity to adenosine were demonstrated by means of reflection contrast microscopy with consecutive image analysis and cell affinity chromatography. High-performance liquid chromatography revealed that thrombin-induced serotonin release of adenosine-sensitive platelets was lower than that of adenosine-resistant cells. Our results indicate platelet heterogeneity and suggest that the platelets with lower adenosine sensitivity may be actively involved in the early interaction between platelets and injured endothelium.
authors.affiliation: Platelet Research and Image Analysis Unit, Institute of Anatomy, University of Münster, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Zhao
authors.forename: T J
authors.initials: TJ
authors.lastname: Filler
authors.forename: C H
authors.initials: CH
authors.lastname: Rickert
authors.forename: J F
authors.initials: JF
authors.lastname: Liu
authors.forename: A D
authors.initials: AD
authors.lastname: Skholl-Engberts
authors.forename: V
authors.initials: V
authors.lastname: Gurevich
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004351:Drug Resistance; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology
chemical_list: D012701:Serotonin; D013917:Thrombin; D000241:Adenosine