Cisapride as a successful treatment for acute intestinal pseudo-obstruction.
Cisapride has been used in the treatment of chronic intestinal pseudo-obstruction with some success; however, the use of cisapride in the treatment of acute pseudo-obstruction has not been adequately studied. We describe a case of acute intestinal pseudo-obstruction successfully treated with cisapride. To our knowledge, this is the second such case reported in the English language literature. Our patient's acute intestinal pseudo-obstruction was probably precipitated by pneumonia and sepsis, and the prompt resolution of his intestinal pseudo-obstruction after initiation of cisapride therapy (despite progressive deterioration of his overall clinical status) implicates cisapride as the cause of the improved intestinal function. Therefore, we suggest that a trial of cisapride be considered for patients with acute intestinal pseudo-obstruction when other therapeutic maneuvers have failed.
Mazloum
B W
BW
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7878, USA.
Barnes
J B
JB
Lee
M
M
D000208:Acute Disease; D020117:Cisapride; D003108:Colonic Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D011859:Radiography
D010277:Parasympathomimetics; D010880:Piperidines; D020117:Cisapride