Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Two taraxastane-type hydroxy triterpenes, taraxasterol and faradiol, isolated from the flowers of Compositae plants Cynara scolymus (artichoke) and Chrysanthemum morifilolium (chrysanthemum), respectively, showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. At 2.0 mumol/mouse, these compounds inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[alpha]anthracene (50 micrograms/mouse).
Yasukawa
K
K
College of Pharmacy, Nihon University, Chiba, Japan.
Akihisa
T
T
Oinuma
H
H
Kaminaga
T
T
Kanno
H
H
Kasahara
Y
Y
Tamura
T
T
Kumaki
K
K
Yamanouchi
S
S
Takido
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity*; D004365:Drugs, Chinese Herbal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D007249:Inflammation; D051379:Mice; D008813:Mice, Inbred ICR; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013261:Sterols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D014315:Triterpenes / Q000494:pharmacology*; D014675:Vegetables
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D004365:Drugs, Chinese Herbal; D013261:Sterols; D014315:Triterpenes; D015127:9,10-Dimethyl-1,2-benzanthracene; C079988:taraxasterol; D013755:Tetradecanoylphorbol Acetate; C100535:faradiol