[A study on erythrocyte membrane band 3 protein anion transport function in chronic respiratory failure patients].
The changes of the structure, content and anion transport function as well as the blood gases and electrolytes inside and outside the erythrocytes were investigated in 3 groups of subjects: type I respiratory failure patients (group 1, n = 40); type II respiratory failure patients (group 2, n = 40) and controls (group 3, n = 37). The results showed that (1) anion transport function impairment of erythrocyte membrane band 3 protein and HCO3-/Cl- exchange restrain may be the reasons that aggravate CO2 retention and respiratory acidosis in cor pulmonale patients with type II respiratory failure. (2) band 3 protein anion transport function impairment in patients of cor pulmonale with type II respiratory failure is reversible. Therefore, it was necessary to supply oxygen to cor pulmonale patients with hypoxemia in time, which may contribute to the recovery of anion transport function.
Yang
X
X
Respiratory Centre, Xinqiao Hospital, Third Military Medical University, Chongqing.
Mao
B
B
Qian
G
G
D000368:Aged; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism*; D001639:Bicarbonates / Q000097:blood; D001692:Biological Transport; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D002712:Chlorides / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000097:blood*
D001457:Anion Exchange Protein 1, Erythrocyte; D001639:Bicarbonates; D002712:Chlorides; D002245:Carbon Dioxide