title: Retinoblastoma (Rb) protein expression and resistance in squamous cell lung carcinomas.
abstract: The purpose of this study was to prove the value of Rb protein expression as a prognostic factor for patients with squamous cell lung carcinoma. The expression of Rb in 75 carcinomas was analyzed immunohistochemically and the resistance to doxorubicin was investigated in vitro. Rb-negative carcinomas were more frequently resistant than Rb-positive carcinomas (p<0.05). A trend for a correlation between the expression of Rb and the expression of glutathione S-transferase-pi was detectable (p=0.08). Patients with Rb-positive carcinomas had a trend for better prognosis, but this result was not statistically significant.
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Volm
authors.forename: G
authors.initials: G
authors.lastname: Stammler
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000378:metabolism*; D004317:Doxorubicin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000903:Antibiotics, Antineoplastic; D009363:Neoplasm Proteins; D016160:Retinoblastoma Protein; D004317:Doxorubicin; D005982:Glutathione Transferase