Isolation of novel saquayamycins as inhibitors of farnesyl-protein transferase.
Sekizawa
R
R
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Iinuma
H
H
Naganawa
H
H
Hamada
M
M
Takeuchi
T
T
Yamaizumi
J
J
Umezawa
K
K
D000190:Actinomyces; D019883:Alkyl and Aryl Transferases; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014166:Transferases / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000187:drug effects; D000095602:Angucyclines and Angucyclinones
D019883:Alkyl and Aryl Transferases; D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D014166:Transferases; D018631:ras Proteins; C100407:saquayamycin E; D000095602:Angucyclines and Angucyclinones; C100408:saquayamycin F; C046893:saquayamycin; C064911:p21(ras) farnesyl-protein transferase