title: [Trypanocidal structure- activity relationship in 9-thioalkylacridines].
abstract: A set of 9-thioalkylacridinones, has been prepared and investigated "in vitro" against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.
authors.affiliation: GERCTOP, URA CNRS, Faculté de Pharmacie, Marseille.
authors.forename: N
authors.initials: N
authors.lastname: Bsiri
authors.forename: C
authors.initials: C
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Kayirere
authors.forename: A M
authors.initials: AM
authors.lastname: Galy
authors.forename: J P
authors.initials: JP
authors.lastname: Galy
authors.forename: J
authors.initials: J
authors.lastname: Barbe
authors.forename: A
authors.initials: A
authors.lastname: Osuna
authors.forename: M C
authors.initials: MC
authors.lastname: Mesa-Valle
authors.forename: J J
authors.initials: JJ
authors.lastname: Castilla Calvente
authors.forename: M N
authors.initials: MN
authors.lastname: Rodriguez-Cabezas
mesh_terms: D000166:Acridines / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents; D066298:In Vitro Techniques; D051379:Mice; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000166:Acridines; D000981:Antiprotozoal Agents; D014344:Trypanocidal Agents
vernacular_title: Relations structure-activité trypanocide chez les 9-thioalkylacridines.