title: A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid.
abstract: The concentration of (R)-N-methylsalsolinol, which is a dopamine-derived neurotoxin selective to dopamine neurons and induces parkinsonism in rats, was found to be increased significantly in the cerebrospinal fluid of untreated patients with Parkinson's disease. The enantio-specific occurrence of (R)-N-methylsalsolinol in cerebrospinal fluid suggests its enzymatic synthesis in the human brain. The individual differences in the activities of the enzymes determining the metabolism of (R)-N-methylsalsolinol in the brain might be involved in the pathogenesis of Parkinson's disease.
authors.affiliation: Department of Neurology, Nagoya University School of Medicine, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Tohgi
authors.forename: P
authors.initials: P
authors.lastname: Dostert
authors.forename: M
authors.initials: M
authors.lastname: Naoi
mesh_terms: D000368:Aged; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D009498:Neurotoxins / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D051381:Rats; D012490:Salsoline Alkaloids / Q000134:cerebrospinal fluid* / Q000378:metabolism; D044005:Tetrahydroisoquinolines
chemical_list: D009498:Neurotoxins; D012490:Salsoline Alkaloids; D044005:Tetrahydroisoquinolines; C032837:salsoline; D004298:Dopamine; D006719:Homovanillic Acid