[Hepatic minimal encephalopathy. The most frequently overlooked, clinically occult "metabolic syndrome" on the cirrhosis patient].
The syndrome of minimal hepatic encephalopathy is used to describe discrete psychomental and neuro-psychological abnormalities in patients with chronic liver disease (cirrhosis) or portosystemic shunt, in whom classical clinical investigations reveal no evidence of mental or cerebro-neurological disorders, and who cannot be assigned to any of the usual stages of hepatic encephalopathy. Disorders of cerebral function, such as lack of concentration, impaired ability to think logically, loss of comprehension, impairment of space perception and the recognition of numbers and letters can be very reliably detected by simple psychometric tests (number-connection test, line-tracing test, handwriting), and are present in as many as 70% of cirrhotics. This may be expressed in everyday life by an impairment of driving ability, and at work by impaired ability to operate a machine. The use of established means of lowering blood ammonia levels (lactulose, ornithine-aspartate) results in a rapid improvement in the symptoms of encephalopathy.
Eisenburg
J
J
Facharzt für Innere Medizin, Gastroenterologie - Hepatologie, Pullach.
D000641:Ammonia / Q000097:blood; D001120:Arginine / Q000008:administration & dosage; D004151:Dipeptides / Q000008:administration & dosage; D006501:Hepatic Encephalopathy / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007792:Lactulose / Q000008:administration & dosage; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011379:Prognosis; D011594:Psychometrics
D004151:Dipeptides; D007792:Lactulose; D000641:Ammonia; D001120:Arginine; C002939:ornithylaspartate
Die hepatische Minimalenzephalopathie. Das meist übersehene, klinisch okkulte "metabolische Syndrom" des Zirrhotikers.