Synthesis and evaluation of 3',5'-di-tert-butyl-4'-hydroxyflavones as potential inhibitors of low density lipoprotein (LDL) oxidation.
The novel flavones 6-28, which display structural analogies with the two well-known lipid peroxidation inhibitors, probucol [1] and butylated hydroxytoluene [2], were synthesized and studied in vitro for their ability to inhibit the copper sulfate or endothelial cell-induced lipid peroxidation of human low-density lipoprotein (LDL). Most of the flavones were active in the range of 0.1-1 microM.
Lewin
G
G
Laboratoire de Pharmacognosie, Faculté de Pharmacie, Caen, France.
Rolland
Y
Y
Privat
S
S
Breugnot
C
C
Lenaers
A
A
Vilaine
J P
JP
Baltaze
J P
JP
Poisson
J
J
D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D017392:Thiobarbituric Acid Reactive Substances / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances