title: The reproducibility of urinary growth hormone measurement in children undergoing adenotonsillectomy: a pilot study.
abstract: The reproducibility of urinary growth hormone levels in normal children and in children undergoing adenotonsillar surgery was investigated. Thirty normal children and 32 children pre- and post-adenotonsillectomy had overnight urinary growth hormone levels measured on two consecutive nights using the technique of immunoradiometric assay. There was no significant difference when levels in each of these groups were compared. Therefore, the results were pooled (n = 94) and the correlation coefficient comparing levels obtained on the first and the second consecutive nights sample was calculated, r = 0.644 (P < 0.001). This work suggests that studies of urinary growth hormone levels in children give reproducible results. Further investigation of this technique as a screening or diagnostic procedure in the clinical setting can now be more widely evaluated.
authors.affiliation: Department of Otolaryngology, Royal United Hospital, Bath, UK.
authors.forename: G
authors.initials: G
authors.lastname: Owen
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: R
authors.initials: R
authors.lastname: Canter
authors.forename: A
authors.initials: A
authors.lastname: Robinson
mesh_terms: D000233:Adenoidectomy; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male; D010092:Oximetry; D010865:Pilot Projects; D012891:Sleep Apnea Syndromes; D014068:Tonsillectomy
chemical_list: D013006:Growth Hormone