Steroid pulse therapy in lupus cystitis.
A middle-aged woman with lupus cystitis showed no other symptoms of lupus vasculitis. Cystoscopic findings revealed mucosal hemorrhage and hyperemia. Histological studies of the bladder showed mucosal edema, inflammatory cellular infiltration and the deposition of immune complexes along the vessels. She was treated with a combination of intravenous methylprednisolone pulse therapy and oral prednisolone. Cystoscopy and histological findings showed appreciable improvement. Elevated urinary levels of chemokines such as interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF) decreased during convalescence. These results suggest that the early diagnosis and treatment with steroid pulse therapy achieves improvement of an unusual vasculitis symptom, lupus cystitis.
Segawa
C
C
First Department of Internal Medicine, School of Medicine, Kanazawa University.
Wada
T
T
Furuichi
K
K
Takasawa
K
K
Yokoyama
H
H
Kobayashi
K
K
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018932:Chemokine CCL2 / Q000652:urine; D018856:Cystitis, Interstitial / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000652:urine; D004359:Drug Therapy, Combination; D004487:Edema / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000652:urine; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000652:urine; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D001745:Urinary Bladder Diseases / Q000473:pathology
D000893:Anti-Inflammatory Agents; D018932:Chemokine CCL2; D016209:Interleukin-8; D011239:Prednisolone; D008775:Methylprednisolone