Pessoine and spinosine, two catecholic berbines from Annona spinescens.
The trunk bark and roots of Annona spinescens have been investigated for their alkaloid content. Two new berbine alkaloids, pessoine (1) and spinosine (2), have been isolated from the bark, and their structures were elucidated by spectroscopic methods. Eight known isoquinoline alkaloids were also obtained. The trypanocidal and antileishmanial activities of these isolated compounds have been investigated.
Queiroz
E F
EF
Laboratoire de Pharmacognosie, U.R.A. 1843 CNRS (BIOCIS), Faculté de Pharmacie. Chatenay-Malabry, France.
Roblot
F
F
Cavé
A
A
Paulo
M Q
MQ
Fournet
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D001600:Berberine Alkaloids; D014344:Trypanocidal Agents; C100547:pessoine; C100548:spinosine