[Biology and clinical relevance of multidrug resistance associated antigen].
Multidrug resistance (MDR) is a main obstacle to cancer chemotherapy. P-glycoprotein(P-gp) is the first antigen discovered to be linked to MDR, and is a energy dependent plasma membrane efflux pump, which actively transports a variety of drugs and substances out of cells. P-gp can be detected by immunological or biochemical (molecular) methods, but both methods have some limitations with respect to sensitivity and specificity. Some studies have demonstrated the adverse prognostic factor of P-gp and some others have not. The discrepancy between various studies is considered to be due to the limitation of methodology for detecting P-gp and the existence of other MDR antigens, for example multidrug resistance associated protein. The clinical roles of MDR reversing agents have not yet been confirmed.
Utsumi
M
M
Nagoya National Hospital.
Shimoyama
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1