title: DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.
abstract: Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa including two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell-mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloantigen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.
authors.affiliation: DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, California 94304-1104, USA.
authors.forename: A
authors.initials: A
authors.lastname: Shibuya
authors.forename: D
authors.initials: D
authors.lastname: Campbell
authors.forename: C
authors.initials: C
authors.lastname: Hannum
authors.forename: H
authors.initials: H
authors.lastname: Yssel
authors.forename: K
authors.initials: K
authors.lastname: Franz-Bacon
authors.forename: T
authors.initials: T
authors.lastname: McClanahan
authors.forename: T
authors.initials: T
authors.lastname: Kitamura
authors.forename: J
authors.initials: J
authors.lastname: Nicholl
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: L L
authors.initials: LL
authors.lastname: Lanier
authors.forename: J H
authors.initials: JH
authors.lastname: Phillips
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000097:blood / Q000276:immunology / Q000302:isolation & purification; D001402:B-Lymphocytes / Q000737:chemistry; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic; D018076:DNA, Complementary / Q000302:isolation & purification; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008222:Lymphokines / Q000378:metabolism; D008565:Membrane Proteins / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008969:Molecular Sequence Data; D009000:Monocytes / Q000737:chemistry; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D000098862:T Lineage-Specific Activation Antigen 1; D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D000939:Epitopes; D008222:Lymphokines; D008565:Membrane Proteins