title: The influence of new 9-(omega-[4-(2-pyrimidinyl)-1-piperazinyl]alkyl) pyrimidino[2,1-f]purines on the central nervous system.
abstract: Synthesis and the results of preliminary pharmacological evaluation of four new 9-substituted pyrimidino[2,1-f]purines, containing pyrimidinyl-piperazine substituent are described. Some of these substances induced hypothermia, antagonism of amphetamine action and neurotoxic effects. All compounds had weaker activity on the central nervous system than previously studied compounds containing phenyl-piperazine substituent.
authors.affiliation: Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Malec
authors.forename: J
authors.initials: J
authors.lastname: Modzelewski
authors.forename: A
authors.initials: A
authors.lastname: Drabczyńska
authors.forename: M
authors.initials: M
authors.lastname: Pawłowski
authors.forename: M
authors.initials: M
authors.lastname: Gorczyca
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D011687:Purines / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D011619:Psychotropic Drugs; D011687:Purines