Systemic lupus erythematosus diagnosed during interferon alfa therapy.
We describe a patient who had clinical manifestations of several autoimmune disorders: Sjögren's syndrome, benign hypergammaglobulinemic purpura of Waldenström, and systemic lupus erythematosus (SLE). The SLE was diagnosed during therapy with interferon alfa. Testing for anti-Ro and anti-La antibodies was negative until the serum was diluted to eliminate a possible prozone phenomenon of antibody excess.
Morris
L F
LF
Department of Dermatology, University of Texas Medical School, Houston, USA.
Lemak
N A
NA
Arnett
F C
FC
Jordon
R E
RE
Duvic
M
M
D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D016898:Interferon-alpha / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011693:Purpura / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000188:drug therapy / Q000209:etiology*; D008258:Waldenstrom Macroglobulinemia / Q000209:etiology*
D016898:Interferon-alpha