Appearance and cellular distribution of lectin-like receptors for alpha 1-acid glycoprotein in the developing rat testis.
A histochemical avidin-biotin technique with three different alpha 1-acid glycoprotein glycoforms showed pronounced alterations in the cellular localization of two alpha 1-acid glycoprotein lectin-like receptors during cell differentiation in the developing rat testis. The binding of alpha 1-acid glycoprotein glycoforms to their receptors is inhibited by steroids. Testosterone, oestradiol and progesterone inhibited the binding of alpha 1-acid glycoprotein glycoform A to its receptor. Cortisone, aldosterone, oestradiol and progesterone inhibited the binding of alpha 1-acid glycoprotein glycoforms B and C to their receptor. A difference in the cellular content of alpha 1-acid glycoprotein glycoforms and alpha 1-acid glycoprotein receptors separates the spermatocytes and the early spermatids from the late spermatids. The difference in receptor composition implies a difference in the effect of different steroid hormones. The Leydig cells contained alpha 1-acid glycoprotein and lectin-like receptors for one of the glycoforms of alpha 1-acid glycoprotein from birth. The interaction between alpha 1-acid glycoprotein glycoforms and their receptors may modulate the actions of testosterone and other steroids in the testis.
Andersen
U O
UO
Faculty of Health Sciences, University of Copenhagen, Denmark.
Bøg-Hansen
T C
TC
Kirkeby
S
S
D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D003348:Cortisone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D006651:Histocytochemistry; D007985:Leydig Cells / Q000378:metabolism; D008297:Male; D008358:Mannose / Q000494:pharmacology; D009961:Orosomucoid / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011975:Receptors, Mitogen / Q000032:analysis*; D012708:Sertoli Cells / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism / Q000502:physiology; D013737:Testis / Q000254:growth & development / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology
D009961:Orosomucoid; D011975:Receptors, Mitogen; D013739:Testosterone; D000450:Aldosterone; D011374:Progesterone; D004958:Estradiol; D008358:Mannose; D003348:Cortisone