Metastases seen on SPECT imaging despite a normal planar bone scan.
Although bone scintigraphy is an extremely sensitive method for the detection of focal bone disease, small lesions below the resolution of planar imaging may be missed. This is a report of a patient with carcinoma of the breast who showed tumor progression 1 year after initial treatment. Complete evaluation was performed in order to detect the origin of increased level of a tumor marker. Although planar bone scintigraphy could not demonstrate any lesion in the spine, multiple metastases were detected in the lumbar and the thoracic spines on SPECT imaging. Only some of these lesions were seen with MRI. Repeat planar bone imaging 6 weeks later showed multiple bone lesions in the lumbar and thoracic areas.
Roland
J
J
Department of Nuclear Medicine, Middelheim General Hospital, Antwerp, Belgium.
van den Weyngaert
D
D
Krug
B
B
Brans
B
B
Scalliet
P
P
Vandevivere
J
J
D000230:Adenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000556:secondary*; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D012680:Sensitivity and Specificity; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000556:secondary*; D013669:Technetium Tc 99m Medronate; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
D014408:Biomarkers, Tumor; D018396:Mucin-1; D013669:Technetium Tc 99m Medronate