title: [Hashimoto toxicosis: diagnostic criteria and a 10-year follow up].
abstract: An study was carried out of the association of Basedow disease (B) and Hashimoto toxicosis (H), the response to the usual therapeutic regimens and prognostic factors for the clinical course. Seventy-one patients with the diagnosis of autoimmune hyperthyroidism were included. Sixty-one of them were prospectively followed for 8.4 +/- 2.2 years (range: 5-10 years). All patients were treated following the same criteria with antithyroid drugs and aggressive therapy (radioiodine or surgery). Two groups were differentiated: group H (62%), with titers of antimicrosomal antibodies (AMSA) > or = 1/6,400 and a positive perchlorate discharge test (PDT), and group B, with AMSA titers < 1/6,400 and negative PDT. During follow-up a three-fold number of relapses was observed in group H compared with group B, a higher frequency towards spontaneous hypothyroidism in the evolution (23% in H versus 0% in B), and higher requirements of radioiodine in H than in B. In our experience, H makes up and important percentage of autoimmune hyperthyroidism (62%) with a clinical course characterized by a higher number of relapses, higher requirements of radioiodine and a higher rate towards spontaneous hypothyroidism.
authors.affiliation: Servicio de Endrocrinología, Hospital Universitario San Carlos, Madrid.
authors.forename: J A
authors.initials: JA
authors.lastname: Rubio
authors.forename: M
authors.initials: M
authors.lastname: Gómez
authors.forename: M A
authors.initials: MA
authors.lastname: Rubio
authors.forename: M
authors.initials: M
authors.lastname: Durán
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez-Salinas
authors.forename: J A
authors.initials: JA
authors.lastname: Cabranes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000628:therapy; D013997:Time Factors
vernacular_title: Hashitoxicosis: criterios diagnósticos y evolución a los diez años de seguimiento.