title: Collagen network remodelling and left ventricular function in constrictive pericarditis.
abstract: OBJECTIVE
  To investigate whether patients with constrictive pericarditis have changes in collagen content and architecture that could influence left ventricular function.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Biopsy specimens of myocardium from 13 patients admitted consecutively for treatment of chronic constrictive pericarditis were compared with normal heart tissue taken at necropsy from 15 patients free of cardiac disease.
  
  
  METHODS
  Pericardiectomy through median sternotomy. Biopsy specimens (4 or 5) were taken from the left ventricular free wall.
  
  
  METHODS
  Biochemical and histological assessment of total collagen content, relative proportion of type I and III collagen, and amount of orthogonal collagen fibre meshwork (crosshatching) in the left ventricular tissue.
  
  
  RESULTS
  There was more collagen in the myocardium of patients with constrictive pericarditis than in controls when measured either biochemically by hydroxyproline content (89.4 v 50.4 mg/g dry weight) or by histological measurement of the collagen fraction of the myocardium (2.4% v 7.0%). Neither of these measurements, however, correlated with left ventricular ejection fraction, pulmonary wedge pressure, or right ventricular end diastolic pressure. The thickness of the fibrous trabeculae in the myocardium was, however, inversely related to both left ventricular ejection fraction (r = -0.76) and deceleration time (r = -0.68). Trabecular thickening was also related to NYHA class, with those in class III and IV having the greatest thickening.
  
  
  CONCLUSIONS
  Changes in collagen content and architecture may contribute to impaired ventricular function in patients with chronic constrictive pericarditis.
authors.affiliation: Department of Cardiac Surgery, Medical School of Catanzaro, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Chello
authors.forename: P
authors.initials: P
authors.lastname: Mastroroberto
authors.forename: R
authors.initials: R
authors.lastname: Romano
authors.forename: F
authors.initials: F
authors.lastname: Perticone
authors.forename: A R
authors.initials: AR
authors.lastname: Marchese
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D002908:Chronic Disease; D015331:Cohort Studies; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010494:Pericarditis, Constrictive / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D018487:Ventricular Dysfunction, Left / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology
chemical_list: D003094:Collagen