title: Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patient with a brain tumor.
abstract: We have initiated a study in which patients suspected of having primary gliomas are given a single intracerebral injection of the thymidine analog 5-[123I]iodo-2'-deoxyuridine ([123I]IUdR). The purpose of the study is to determine the biodistribution of the radiopharmaceutical and to calculate dose estimates to the tumor and normal tissues.
  
  
  METHODS
  A patient with a cystic glioma was injected with [123I]IUdR. Whole-body scans and brain scans were obtained at various times after injection, and blood, urine and stools were collected and assayed for radioactivity to assess its biodistribution and clearance.
  
  
  RESULTS
  Scintigraphic imaging demonstrated that the distribution of radiolabeled IUdR was mainly confined to the tumor (injection site), stomach and bladder. Disappearance from the tumor site and blood clearance were delayed probably due to collection in the cystic lesion. Eighty percent of the injected dose was recovered in the urine.
  
  
  CONCLUSIONS
  The pharmacokinetics of [123I]IUdR locoregionally administered to a human glioma in situ resembled those observed in a rat glioma model where administration of the radiopharmaceutical radiolabeled with the Auger electron emitter 125I was therapeutically effective.
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: A I
authors.initials: AI
authors.lastname: Kassis
authors.forename: S S
authors.initials: SS
authors.lastname: Tumeh
authors.forename: P Y
authors.initials: PY
authors.lastname: Wen
authors.forename: J
authors.initials: J
authors.lastname: Baranowska-Kortylewicz
authors.forename: A D
authors.initials: AD
authors.lastname: Van den Abbeele
authors.forename: R E
authors.initials: RE
authors.lastname: Zimmerman
authors.forename: P A
authors.initials: PA
authors.lastname: Carvalho
authors.forename: B M
authors.initials: BM
authors.lastname: Garada
authors.forename: W C
authors.initials: WC
authors.lastname: DeSisto
authors.forename: N O
authors.initials: NO
authors.lastname: Bailey
authors.forename: F P
authors.initials: FP
authors.lastname: Castronovo
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: P M
authors.initials: PM
authors.lastname: Black
authors.forename: S J
authors.initials: SJ
authors.lastname: Adelstein
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015552:Injections, Intralesional; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D007065:Idoxuridine