Severe necroziting vasculitis in a patient with hepatitis C virus infection treated by interferon.
We report a case of polyarteritis nodosa occurring in a patient with hepatitis C, ten days after the beginning of alpha-IFN therapy. There was no cryoglobulinemia. Serum HCV-RNA was detectable before INF therapy and disappeared during the vasculites. The patient received boli of methylprednisolone and the neurological and skin lesions regressed after 5 months. This observation could suggest a precocious response to alpha-INF and a relationship between INF and the occurrence of vasculites.
Pateron
D
D
Services d'Hepatogastroentérologie, Hôpital Jean Verdier, Bondy, France.
Fain
O
O
Sehonnou
J
J
Trinchet
J C
JC
Beaugrand
M
M
D000998:Antiviral Agents / Q000009:adverse effects*; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000209:etiology*
D000998:Antiviral Agents; D016898:Interferon-alpha