title: [Immunomodulating action of hyaluronic acid and its hydrolysis products in health and in Staphylococcus infection].
abstract: Potassium hyaluronate was found to suppress the development of a humoral response and delayed hypersensitivity, while hyaluronidase and the incubate of potassium hyaluronate and hyaluronidase enhanced the manifestations of the humoral response and delayed hypersensitivity. The suppressive effect of potassium hyaluronate was mediated by light erythrocytes, whereas the stimulating effect of hyaluronidase the incubates of potassium hyaluronate and hyaluronidase was mediated by heavy erythrocytes. In Staphylococcus infection, hyaluronidase and the incubates of potassium hyaluronate and hyaluronidase enhanced the development of a humoral response and failed to affect the manifestations of delayed hypersensitivity.
authors.forename: A I
authors.initials: AI
authors.lastname: Lazarev
authors.forename: L G
authors.initials: LG
authors.lastname: Prokopenko
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006820:Hyaluronic Acid / Q000378:metabolism / Q000494:pharmacology*; D006868:Hydrolysis; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid
vernacular_title: Immunomoduliruiushchee deĭstvie gialuronovoĭ kisloty i produktov ee gidroliza v norme i pri infistirovanii stafilokokkom.