[Expression of epidermal growth factor receptors and their ligands in malignant tumors of the breast].
Epidermal growth factor receptors (EGFR) have been investigated in the tumors of 166 breast cancer patients and concentrations of their ligands (alpha-TGF and EGF) were measured in 104 tumors by radioimmunoassay. EGFR and both growth factors were simultaneously detected in 18% and EGFR and one of the ligands were found in 11%. There were trends to higher frequency of EGFR expression in advanced tumors, in ductal and lobular infiltrative cancers with high grade of malignancy and in estrogen receptor negative breast cancers. A possible role of the parameters studied in the prediction of breast cancer and in the choice of therapy is discussed.
Gershteĭn
E S
ES
Ermilova
V D
VD
Kuz'mina
Z V
ZV
Kuzlinskiĭ
N E
NE
Letiagin
V P
VP
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000628:therapy; D018275:Carcinoma, Lobular / Q000737:chemistry / Q000628:therapy; D004815:Epidermal Growth Factor / Q000032:analysis; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D008024:Ligands; D008875:Middle Aged; D011863:Radioimmunoassay; D015291:Transforming Growth Factors / Q000032:analysis
D008024:Ligands; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D066246:ErbB Receptors
Ekspressiia retseptorov épidermal'nogo faktora rosta i ikh ligandov v zlokachestvennykh opukholiakh molochnoĭ zhelezy.