Essential thrombocythemia with BCR/ABL rearrangement.
Essential thrombocythemia (ET) was diagnosed clinically in three patients Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-abl positive. The first patient received an allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement.
Kwong
Y L
YL
University Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong.
Chiu
E K
EK
Liang
R H
RH
Chan
V
V
Chan
T K
TK
D000328:Adult; D001483:Base Sequence; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D013922:Thrombocytosis / Q000235:genetics*
D016044:Fusion Proteins, bcr-abl