title: Local excision and external beam radiotherapy in early rectal cancer.
abstract: OBJECTIVE
  To assess the local control and survival of local excision and postoperative radiation in patients with early stage rectal cancer.
  
  
  METHODS
  From 1980 to 1992, 21 patients with clinical stage T1-2NxM0 adenocarcinoma of the middle and lower rectum were treated with transanal excision and postoperative external beam radiotherapy (44.6 Gy). The pathologic T stages were: 9 T1 (43%) and 12 T2 (57%). One patient had unassessable resection margins. The median follow-up was 54 months (range: 18-128 months).
  
  
  RESULTS
  The actuarial local recurrence-free survival at 5 years was 85.2%, and the overall survival at 5 years was 80.6%. One patient developed a local recurrence and distant metastases at 22 months, and two patients had local recurrence at 11 and 15 months, respectively; both had abdomino-perineal resection (APR) and one remained free of disease 16 months after APR. The incidence of Grade 3 diarrhea was 5%. Sphincter function was good to excellent in the 18 patients with local control. No patients developed clinical evidence of pelvic lymph node recurrence.
  
  
  CONCLUSIONS
  These results are similar to other published series and suggest that this approach is feasible in selected patients with T1-2NxM0 rectal cancer and results in good long-term control of the disease.
authors.affiliation: Divisione di Radioterapia, Università Cattolica S. Cuore, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Valentini
authors.forename: A G
authors.initials: AG
authors.lastname: Morganti
authors.forename: M
authors.initials: M
authors.lastname: De Santis
authors.forename: F M
authors.initials: FM
authors.lastname: Vecchio
authors.forename: C
authors.initials: C
authors.lastname: Coco
authors.forename: A
authors.initials: A
authors.lastname: Picciocchi
authors.forename: N
authors.initials: N
authors.lastname: Cellini
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000401:mortality / Q000628:therapy*