Emerging roles of nitric oxide in inflammation.
The short-lived, highly reactive NO radical arises in two ways: 1) a rapidly triggered process well suited for homeostatic fine-tuning of blood pressure and 2) a prolonged high-level production best suited for microbicidal activity. Roles in vascular "leakiness" and leukocyte extravasation are also emerging. Continued investigation may yield new therapies addressing individual facets of inflammation.
Lyons
C R
CR
Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, USA.
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology; D008264:Macrophages / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology*
D009569:Nitric Oxide