[Role of kinins in local and systemic inflammatory reactions].
The development of highly sensitive and specific immunoassays allowed the characterization of bradykinin and desArg9-BK metabolism in vitro. The same methods were used to study the time course evolution of the tissue content of both kinins in an carragenan inflammatory model. Quantification of T-kininogen in the same animal model allowed to show an influence of BK on the neosynthesis of this acute phase protein.
Adam
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Faculté de Pharmacie de l'Université de Montréal.
D000818:Animals; D001120:Arginine / Q000378:metabolism; D001920:Bradykinin / Q000378:metabolism*; D004487:Edema / Q000378:metabolism; D015773:Enalaprilat / Q000494:pharmacology; D066298:In Vitro Techniques; D007249:Inflammation / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D001120:Arginine; D015773:Enalaprilat; D001920:Bradykinin
Rôle des kinines dans la réaction inflammatoire locale et systémique.