title: Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids.
abstract: Synthesis and antiinflammatory properties of new carboxylic acids containing the 2,3-dihydro-1,4-benzodioxin subunit are described. The 2-(2,3-dihydro-1, 4-benzodioxin-6-yl)acetic acid was of comparable potency to Ibuprofen, in carrageenan induced rat paw edema assay.
authors.affiliation: Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Vázquez
authors.forename: G
authors.initials: G
authors.lastname: Rosell
authors.forename: M D
authors.initials: MD
authors.lastname: Pujol
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004147:Dioxins / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005528:Foot / Q000473:pathology; D007052:Ibuprofen / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004147:Dioxins; D002351:Carrageenan; D007052:Ibuprofen