Delay or inhibition of rat lens opacification using pantethine and WR-77913.
Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons. In the radiation or selenite models, each test reagent was administered 15 to 30 min prior to initiation of cataract by a single injection of Na2SeO3 or a single exposure to 15 Gy (gray) gamma radiation. In the galactose, streptozotocin and Royal College of Surgeons models where the cataractogenic insult was continuous, repeated administrations of pantethine and WR-77913 were necessary. The results suggested that protein aggregation and lens opacification associated with a variety of physiological and biochemical mechanisms can be delayed or inhibited using a systemic administration of pantethine or WR-77913.
Clark
J I
JI
Department of Biological Structure, University of Washington, Seattle 98195, USA.
Livesey
J C
JC
Steele
J E
JE
D004999:Amifostine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005690:Galactose; D007908:Lens, Crystalline / Q000648:ultrastructure; D008297:Male; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011489:Protein Denaturation / Q000187:drug effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D018038:Sodium Selenite; D013311:Streptozocin
D010204:Pantetheine; C035284:WR 77913; D013311:Streptozocin; C005425:pantethine; D018038:Sodium Selenite; D004999:Amifostine; D005690:Galactose