title: [Standardization and acceleration of quantitative analysis of dynamic MR mammographies via parametric images and automatized ROI definition].
abstract: OBJECTIVE
  To evaluate quantitative analysis of dynamic breast MRI studies using a dedicated PC based diagnosis system (DS) providing parametric images and automatic ROI definition as compared to the standard subtraction image, manual-ROI based procedure.
  
  
  METHODS
  We compared the diagnostic usefulness of parametric versus subtraction images in terms of visualisation of enhancement inhomogeneities and enhancement velocities. Quantitative analysis of enhancing lesions of 15 breast MRI studies was performed using both the DS and the system's console software (SC). We assessed the time needed for complete quantitative analysis and number of lesions evaluated. This was followed by assessment of within-reader and between-reader variability or within-case reproducibility of results of quantitative analysis.
  
  
  RESULTS
  Parametric images are superior to subtraction images in visualizing enhancement inhomogeneities or ring enhancement in breast cancers. Mean time needed for analysis at DS and SC was 4 (3-5) min. and 23 (8-39) min., respectively. During this time period, significantly more lesions were evaluated per case using the DS as compared to the SC (2-14 vs. 1-6). Mean within-reader variability of enhancement velocities of the same lesions was 0% and 25% (DS and SC); between-reader variability of enhancement values obtained in the same lesions was 11% (DS) versus 41% (SC).
  
  
  CONCLUSIONS
  The DS significantly cuts down the time needed for quantitative analysis. It significantly improves reproducibility of quantitative enhancement values due to standardization of ROI analysis.
authors.affiliation: Radiologische Universitätsklinik Bonn.
authors.forename: C K
authors.initials: CK
authors.lastname: Kuhl
authors.forename: H B
authors.initials: HB
authors.lastname: Bieling
authors.forename: G
authors.initials: G
authors.lastname: Lutterbey
authors.forename: T
authors.initials: T
authors.lastname: Sommer
authors.forename: E
authors.initials: E
authors.lastname: Keller
authors.forename: H H
authors.initials: HH
authors.lastname: Schild
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D015203:Reproducibility of Results; D012984:Software
vernacular_title: Standardisierung und Beschleunigung der quantitativen Analyse dynamischer MR-Mammographien durch Parameterbilder und automatisierte ROI-Definition.