title: [Plasma fibrin monitor level in DIC patients with a hematopoietic malignancy].
abstract: The Plasma level of soluble fibrin monomer (sFM) was measured in 218 patients with a hematopoietic malignancy. Of them, 198 were diagnosed with disseminates intravascular coagulation (DIC), 20 with Pre-DIC, and 20 with Non-DIC. Pre-DIC was retrospectively defined as the condition at least 1 week before the onset of DIC. The plasma levels of sFM, thrombin-anti-thrombin III complex (TAT), plasmin alpha 2-antiplasmin inhibitor complex (PIC), and FDP-D-dimer were significantly higher in patients with DIC than in those with Non-DIC. These levels were significantly higher in patients with Pre-DIC than in those with Non-DIC. Among these hemostatic parameters, the plasma sFM showed the highest sensitivity and specificity for DIC or Pre-DIC. These findings suggests that sFM is the most valuable marker hemostatic for the diagnosis of DIC and Pre-DIC.
authors.affiliation: 2nd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hiyoyama
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: M
authors.initials: M
authors.lastname: Shimura
authors.forename: H
authors.initials: H
authors.lastname: Deguchi
authors.forename: S
authors.initials: S
authors.lastname: Nagaya
authors.forename: Y
authors.initials: Y
authors.lastname: Wakita
authors.forename: K
authors.initials: K
authors.lastname: Deguchi
authors.forename: H
authors.initials: H
authors.lastname: Shiku
mesh_terms: D015415:Biomarkers / Q000032:analysis; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis*; D005337:Fibrin / Q000032:analysis*; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D005337:Fibrin