[New data on heliotropic dystrophy of the liver].
The outbreak of heliotropic dystrophy (HD) in Khalton region of Tadzhikistan registered in 1992 caused 3096 cases. Of them 83 cases underwent thorough examination. Liver biopsy performed in the patients showed primarily vascular lesion rather than inflammation. This makes more logical to denote the above disorder as heliotropic hepatoangiopathy. Foci of bleeding in the liver manifested ultrasonically in the form of previously unobserved silent zones. Metabolism investigations discovered activation of lipid peroxidation, subnormal zinc and elevated copper concentrations in plasma. Nitrogenous metabolism was characterized by high levels of medium-size molecular peptides (markers of endogenous intoxication), oxyprolin, amino nitrogen and sialic acid, reduced urea formation. The serum contained increased quantities of low density lipoproteins, TH, low content of high density lipoproteins, cholesterol, PL indicating membranous impairment of endoplasmic network and disintegration of lipid-lipid and lipid-protein complexes on its surface.
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D001344:Autopsy; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D010939:Plant Poisoning / Q000453:epidemiology* / Q000473:pathology; D013620:Tajikistan / Q000453:epidemiology
Nekotorye novye dannye o geliotropnoi distrofii pecheni.