title: Captopril, an angiotensin-converting enzyme inhibitor, induced pulmonary infiltration with eosinophilia.
abstract: In this study, we investigated the association between the drug-induced pulmonary infiltration with eosinophilia (PIE) syndrome in a patient with hypertension and the angiotensin-converting enzyme inhibitor (ACE-I) captopril. Although the patient developed diffuse lung field infiltrates accompanied by productive cough and striking peripheral eosinophilia, these symptoms disappeared after termination of the administration of captopril, pronase and cephalexine. Furthermore, the results of the peripheral lymphocyte stimulation test, skin patch test and provocation test under informed consent showed a positive reaction only for captopril. Therefore, this patient was diagnosed as captopril-induced PIE syndrome.
authors.affiliation: Division of Internal Medicine, Minamiuwa Ehime Prefectural Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Shiode
authors.forename: M
authors.initials: M
authors.lastname: Sekiya
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: C
authors.initials: C
authors.lastname: Iwanaga
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008213:Lymphocyte Activation; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D011859:Radiography; D012882:Skin Tests; D013577:Syndrome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril