[Lipoprotein(a) concentrations in type I diabetes mellitus].
OBJECTIVE
To determine the distribution of lipoprotein(a) levels and prevalence of hyperLp(a) in diabetes mellitus type I (IDDM). To analyze the effect of glycemic control and microalbuminuria on Lp(a) levels.


METHODS
Cross-sectional study of 263 subjects with IDDM with a mean age of 19.2 +/- 11.6 years and an evolutive course of 6.3 +/- 6.5 years. Apart from Lp(a), measurements were obtained from serum levels of lipids, apolipoproteins AI and B, fructosamine, glycosilated hemoglobin (HbA1c), and albuminuria in all patients.


RESULTS
Mean serum concentrations of Lp(a) were 16.5 +/- 18.1 mg/dl and 18.5% of patients had Lp(a) levels > 30 mg/dl [hyperLp(a)]. With a multivariate regression analysis, the only variable correlated with Lp(a) levels was cholesterol LDL (p < 0.001). Patients with hyperLp(a) did not differ from the other patients in any of the other variables analyzed, and patients with HbA1c higher and lower than 8% had similar mean serum Lp(a) concentrations (14.0 +/- 16 vs. 17.9 +/- 20). Lp(a) concentration was also similar among patients with albuminuria higher and lower than 20 micrograms/min (16.6 +/- 20 vs. 17.7 +/- 16).


CONCLUSIONS
Control of glycemia and microalbuminuria have no effect on Lp(a) concentrations in diabetes mellitus type I. HyperLp(a) is not indicative of a poor glycemic control.
Figueroa
A C
AC
Servicios de Endocrinología, Hospital de la Santa Creu y Sant Pau, Barcelona.
Gil
R L
RL
Pedragós
A C
AC
González
G C
GC
Marqués
R B
RB
Díaz
J A
JA
Llanos
J O
JO
Pérez
A P
AP
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D013997:Time Factors
D017270:Lipoprotein(a)
Concentraciones de la lipoproteína (a) en la diabetes mellitus tipo I.