title: Brain penetration of intrathecal iomeprol in dogs.
abstract: OBJECTIVE
  Iomeprol, a new nonionic iodinated compound for intravascular use, is being evaluated as a myelographic contrast agent because of its low neurotoxicity. This study aimed to assess the degree of brain penetration of iomeprol after intrathecal administration.
  
  
  METHODS
  Brain penetration in dogs was investigated by CT and compared with that of iopamidol, iohexol, and ioversol, currently used as myelographic contrast media (CM). Nervous tissue density was determined in different brain structures by recording Hounsfield values.
  
  
  RESULTS
  The experiments revealed that CM diffused from the cisternae into the parenchyma, reaching a maximum at 5-24 h after injection. The density of the examined brain regions was still higher than the preinjection levels 24 h later. No differences in brain penetration were observed among the CM investigated.
  
  
  CONCLUSIONS
  The study has shown that iomeprol penetrates into the brain to the same extent as the most widely used myelographic CM.
authors.affiliation: Research Center, Bracco SpA, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: La Noce
authors.forename: P
authors.initials: P
authors.lastname: Lorenzon
authors.forename: F
authors.initials: F
authors.lastname: Pugliese
authors.forename: G
authors.initials: G
authors.lastname: Pellecchi
authors.forename: I
authors.initials: I
authors.lastname: Orlandini
authors.forename: P
authors.initials: P
authors.lastname: Tirone
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D005260:Female; D007278:Injections, Spinal; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol