[Hormonal premedication in endometrium ablation--results of a prospective comparative study].
In a prospective study in 40 patients the pretreatment for endometrial ablation with a gestagen (Orgametril 10 mg/die), danazol (600 mg/die) and an injection of a GnRH-analogon (Decapeptyl-Depot) was compared with a control group without pretreatment. The subjective estimation of the surgeon (endometrial thickness and depth of coagulation) showed a sufficient pretreatment in 90 % of all cases following danazol- and GnRH-analogon-pretreatment. In 90 % of the danazol- and GnRH-analogon pretreated group the histological findings showed also an atrophic or little proliferative endometrium. In a follow up of 6 months after endometrial ablation the highest amenorrhoea-rates were reached following danazol- and GnRH-analogon pretreatment. These two regimes should be used for the pretreatment for endometrial ablation.
Römer
T
T
Klinik für Frauenheilkunde und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald.
Müller
J
J
Bojahr
B
B
Schwesinger
G
G
Lober
R
R
D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D003613:Danazol / Q000008:administration & dosage* / Q000009:adverse effects; D003692:Delayed-Action Preparations; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D004965:Estrogen Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008186:Luteolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008234:Lynestrenol / Q000008:administration & dosage* / Q000009:adverse effects; D008595:Menorrhagia / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011292:Premedication; D045167:Progesterone Congeners / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000008:administration & dosage* / Q000009:adverse effects
D003692:Delayed-Action Preparations; D004965:Estrogen Antagonists; D008186:Luteolytic Agents; D045167:Progesterone Congeners; D017329:Triptorelin Pamoate; D003613:Danazol; D008234:Lynestrenol
Hormonale Vorbehandlung für die Endometriumablation--Ergebnisse einer prospektiven Vergleichsstudie.