Kaposi's sarcoma developing in a liver graft.
The case reported herein involved a patient who developed Kaposi's sarcoma (KS) in the liver graft, with severe liver disfunction and eventually the patient's death. This patient is our only KS case among the 7 neoplasias arising de novo (6 lymphoproliferative syndromes) in a series of 402 liver transplants (382 immunosuppressed with cyclosporine and prednisolone and 20 with FK-506 and prednisolone). The anatomic distribution of the KS in the autopsy study, and the HLA haplotypes typed in the donor and in the recipient, suggest that the KS arose in the stromal endothelial cells of the donor liver.
Colina
F
F
Departamento de Anatomía Patológica, Hospital Universitario 12 de Octubre. Universidad Complutense, Madrid, España.
López-Ríos
F
F
Lumbreras
C
C
Martínez-Laso
J
J
García
I G
IG
Moreno-González
E
E
D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000209:etiology*
D007166:Immunosuppressive Agents