[In vitro chemosensitivity test for seven undifferentiated thyroid carcinoma cell lines using MTT assay].
In the current study, we ran a chemosensity test on 7 human undifferentiated carcinoma cell lines against 10 anticancer compounds using MTT assay. Efficacy was estimated by comparing fifty percent inhibitory concentration (IC50) with the peak plasma concentration. The results showed that the 7 cell lines could be divided into two groups which had different (high or low) chemosensitivity, and that in the high sensitivity group, ACD, VCR, and etoposide were indicated as useful drugs. Our results suggest that it may be impossible to rescue all undifferentiated carcinoma patients by chemotherapy alone because the tumor may consist of 2 clones which have a different chemosensitivity.
Osawa
Y
Y
Second Division of Surgery, Kanagawa Cancer Center, Japan.
Yoshida
A
A
Asaga
T
T
Kawahara
S
S
Yanoma
S
S
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology; D002277:Carcinoma / Q000473:pathology*; D002945:Cisplatin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles; D013964:Thyroid Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D001761:Bleomycin; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; C022616:thiazolyl blue; D002945:Cisplatin; D008727:Methotrexate