title: Clinical evaluation of roxithromycin in patients with acne.
abstract: On the basis of reports that erythromycin is effective in the treatment of acne, we investigated whether roxithromycin (ROM), a new derivative of erythromycin, might also be effective in treating acne. Roxithromycin was administered to 30 patients with acne for 8 weeks. General improvement was assessed 8 weeks after the initiation of the therapy with a six-graded scale as follows; 1: good improvement, 2: moderate improvement, 3: slight improvement, 4: no change, 5: worsening, and 6: no assessment. The percentage of good or moderate improvement was 73.3%, and that of good improvement alone was 20.0%. Our results suggest that ROM is effective in the treatment of acne.
authors.affiliation: Department of Dermatology, Kansai Medical University, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akamatsu
authors.forename: S
authors.initials: S
authors.lastname: Nishijima
authors.forename: M
authors.initials: M
authors.lastname: Akamatsu
authors.forename: I
authors.initials: I
authors.lastname: Kurokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Asada
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D015575:Roxithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D015575:Roxithromycin