title: The Rel family of eukaryotic transcription factors.
abstract: Members of the Rel transcription factor family mediate the response of eukaryotic cells to a broad range of environmental threats, in addition to serving an essential role in the development of certain vertebrate and insect cells. It is now apparent that there are two classes of Rel proteins, which differ in whether they bind DNA as monomers or dimers and which use markedly different mechanisms to transduce intracellular signals. Recent progress has been made towards understanding the structural basis for the fascinating biology of these proteins.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: M
authors.initials: M
authors.lastname: Chytil
authors.forename: G L
authors.initials: GL
authors.lastname: Verdine
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D029721:Drosophila Proteins; D005057:Eukaryotic Cells / Q000378:metabolism*; D007313:Insecta / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D005810:Multigene Family; D016328:NF-kappa B / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D052002:NF-kappa B p50 Subunit; D010750:Phosphoproteins / Q000378:metabolism; D011487:Protein Conformation; D055503:Protein Multimerization; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D020569:Proto-Oncogene Proteins c-rel; D051841:Transcription Factor RelB; D014157:Transcription Factors / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000502:physiology; D014714:Vertebrates / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D020569:Proto-Oncogene Proteins c-rel; D014157:Transcription Factors; D051841:Transcription Factor RelB; C077938:cact protein, Drosophila; D004247:DNA