Role of CD4+ and CD8+ T cells in mouse hepatitis virus infection in mice.
Viral growth and histopathological changes in the liver after intraperitoneal infection with mouse hepatitis virus, strain JHM were compared among normal C57BL/6 mice, those depleted of CD4+ T cells, CD8+ T cells and both T cell subsets. Viral growth in mice depleted of CD4+ T cells increased slightly, but pathological changes resembled those in normal mice. In contrast, the hepatitis was exacerbated in mice depleted of CD8+ T cells and those depleted of both T cell subsets. These results suggest that CD8+ T cells play a key role although both T cell subsets are involved in protection against mouse hepatitis virus infection in mice.
Kyuwa
S
S
Department of Animal Pathology, University of Tokyo, Japan.
Machii
K
K
Shibata
S
S
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D017637:Clonal Deletion / Q000276:immunology; D018352:Coronavirus Infections / Q000276:immunology / Q000473:pathology*; D006524:Hepatitis, Viral, Animal / Q000276:immunology / Q000473:pathology*; D008099:Liver / Q000473:pathology / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D006517:Murine hepatitis virus / Q000472:pathogenicity*; D013047:Specific Pathogen-Free Organisms