Recombinant allergens for diagnosis and therapy of allergic diseases.
A considerable number of cDNAs coding for allergens have been isolated and expressed. Structural and immunological similarities between recombinant allergens and natural allergens indicate that a sufficient panel of recombinant allergens can be produced for diagnosis and therapy of allergic diseases. Recent studies document the successful in vitro and in vivo determination of a patient's allergen profile (allergogram) with recombinant allergens and encourage the use of recombinant allergens for specific therapy.
Valenta
R
R
University of Vienna, Austria.
Kraft
D
D
D000485:Allergens / Q000235:genetics* / Q000276:immunology; D000818:Animals; D003888:Desensitization, Immunologic; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D016219:Immunotherapy, Adoptive; D051379:Mice; D051381:Rats; D011994:Recombinant Proteins / Q000276:immunology; D012882:Skin Tests
D000485:Allergens; D000939:Epitopes; D011994:Recombinant Proteins