[A study on combined treatment with ANP and dopamine in acute renal failure in rats].
Acute renal failure (ARF) model was made by intraperitoneal injection of cisplatin at a dosage of 10mg/kg. After the procedure, the rats were given atrial natriuretic polypeptide (ANP) and dopamine (DA) as well as ANP or DA individually. The results indicated that combined treatment with ANP and DA was more effective for improvement of renal function in ARF (increase of GFR) than individual treatment with either ANP or DA. Dopamine can effectively reverse the side-effect of hypotension of ANP.
Chen
X
X
Division of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang.
Yang
H
H
Mai
W
W
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D002945:Cisplatin; D004298:Dopamine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005919:Glomerular Filtration Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012076:Renal Agents / Q000008:administration & dosage*
D012076:Renal Agents; D009320:Atrial Natriuretic Factor; D002945:Cisplatin; D004298:Dopamine