title: Late onset of isolated central nervous system metastasis of liposarcoma--a case report.
abstract: Metastatic soft-tissue sarcoma of the central nervous system (CNS) is exceedingly rare. We report a case of a 56-year-old male treated for a right lower extremity liposarcoma at the age of 30 years, whose first recurrence was an intracerebral metastasis occurring 26 years after resection of the primary tumor. Initial treatment of the metastasis with surgical resection and adjuvant radiotherapy was followed rapidly by CNS recurrence in 3 months. Further debulking and interstitial brachytherapy were unsuccessful in controlling disease progression. Clinical presentation and treatment of brain metastases in soft-tissue sarcoma are discussed.
authors.affiliation: Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: G
authors.initials: G
authors.lastname: Arepally
authors.forename: L C
authors.initials: LC
authors.lastname: Kenyon
authors.forename: E
authors.initials: E
authors.lastname: Lavi
mesh_terms: D001918:Brachytherapy; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg; D008080:Liposarcoma / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D003037:Cobalt Radioisotopes