title: [Chronic hepatitis C and interferon alpha treatment].
abstract: The authors discuss some of the aspects of chronic hepatitis C infection e.g. interferon alpha treatment. They describe the current state of knowledge on HCV pathophysiology: liver pathology, immunological phenomena, autoimmunity. Attention is paused on development of hepatitis C serodiagnosis which enables patient monitoring during infection and therapy: detection of serum anti-HCV antibodies with third and fourth generation ELISA kits; the polymerase chain reaction (PCR), which enables detection of viral nucleic acid (HCV-RNA). Some differences in interferon therapy in children are also described.
authors.affiliation: Dział Immunologii Klinicznej Centrum Zdrowia Dziecka w Warszawie.
authors.forename: A C
authors.initials: AC
authors.lastname: Skarpetowski
authors.forename: J
authors.initials: J
authors.lastname: Pawłowska
authors.forename: K
authors.initials: K
authors.lastname: Madaliński
mesh_terms: D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D016898:Interferon-alpha
vernacular_title: Przewlekłe wirusowe zapalenie watroby typu C i leczenie interferonem alfa.