title: The Saccharomyces cerevisiae kinetochore.
abstract: Accurate chromosome segregation is dependent on a specialized chromosomal structure, the kinetochore/centromere. The only essential constituent of the S. cerevisiae kinetochore established today is CBF3, a multisubunit complex that binds to S. cerevisiae centromere DNA. Therefore CBF3 and its four components, Cbf3a, Cbf3b, Cbf3c and Cbf3d, will form the centerpiece of this review. In addition, we will describe proteins that are putatively involved in kinetochore function specifically in the context with CBF3 interaction. Furthermore, we discuss the role of the S. cerevisiae kinetochores in a putative cell cycle checkpoint control and in microtubule attachment.
authors.affiliation: Institut für Biochemie, Genetik und Mikrobiologie, Universität Regensburg, Germany. Johannes.Lechner@vkl.uni-regensburg
authors.forename: J
authors.initials: J
authors.lastname: Lechner
authors.forename: J
authors.initials: J
authors.lastname: Ortiz
mesh_terms: D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D008870:Microtubules / Q000502:physiology; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins
chemical_list: C092348:CEP3 protein, S cerevisiae; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins