Thallium-201 uptake, histopathological differentiation and Na-K ATPase in lung adenocarcinoma.
To clarify differences in accumulation in 201 Tl scintigraphy, we examined the relationship between uptake of 201 Tl, histopathological differentiation and Na-K ATPase.


METHODS
Thallium-201 SPECT was performed twice: 15 min (early scan) and 120 min (delayed scan) after intravenous injection of 3 mCi 201 Tl-chloride. The uptake ratio of 201 Tl was calculated and compared with the grade of differentiation and the staining pattern of Na-K ATPase.


RESULTS
The sensitivity of 201 Tl SPECT for well-differentiated adenocarcinomas was lower than that for moderately and poorly differentiated ones. The uptake ratio on the delayed scan was significantly lower in the well-differentiated group than that in the moderately and poorly differentiated groups. This parameter was also significantly higher in the Na-K ATPase-positive group than the -negative group.


CONCLUSIONS
These results indicate that the uptake ratio of 201 Tl SPECT may be a noninvasive indicator of the grade of pathological differentiation of adenocarcinoma and provide insight into the relationship among 201 Tl SPECT, malignancy and Na-K ATPase.
Takekawa
H
H
First Department of Medicine, School of Medicine, Hokkaido University, Japan.
Itoh
K
K
Abe
S
S
Ogura
S
S
Isobe
H
H
Furudate
M
M
Kawakami
Y
Y
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000473:pathology; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes; D000254:Sodium-Potassium-Exchanging ATPase