Enhancement of antibody response to bovine herpesvirus 1 with non-specific immunostimulants.
Stimulatory effects of aluminium hydroxide, lipopolysaccharide (LPS), muramyldipeptide (MDP), and empty liposomes on the antigenicity of inactivated bovine herpesvirus 1 were tested in mice. Compared with the standard effect of aluminium hydroxide, stronger antibody responses were observed in mice treated with empty liposomes or LPS alone, or a combination thereof. The strongest antibody response was recorded in mice treated with a combination of inactivated BHV-1, MDP and empty liposomes.
Hampl
J
J
Veterinary Research Institute, Brno, Czech Republic.
Franz
J
J
Stĕpánek
J
J
Toman
M
M
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D008081:Liposomes; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000536:Aluminum Hydroxide