title: Primary structure of bovine aorta biglycan core protein deduced from cloned CDNA.
abstract: Two overlapping cDNA clones for core protein of a biglycan of bovine aorta were isolated from a pSPORT bovine aorta tissue cDNA library. The 2043-bp cDNA contains a 114-bp 5' untranslated region, a 1224-bp cDNA open reading frame and a 705-bp 3' untranslated region. The encoded core preproprotein contains a prepeptide (residues no. -37 to -19) and a propeptide (residues no. -18 to -1), with 369 amino acid residues corresponding to a molecular mass of 41.6 kDa. The deduced amino acid sequence revealed a striking homology to rat vascular smooth muscle cell, human bone and bovine articular cartilage biglycans from cell culture.
authors.forename: J H
authors.initials: JH
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Radhakrishnamurthy
authors.forename: S R
authors.initials: SR
authors.lastname: Srinivasan
authors.forename: G S
authors.initials: GS
authors.lastname: Berenson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001483:Base Sequence; D058578:Biglycan; D002417:Cattle; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification*; D016326:Extracellular Matrix Proteins; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D011509:Proteoglycans / Q000235:genetics*; D017421:Sequence Analysis
chemical_list: C546884:BGN protein, human; C546886:Bgn protein, rat; D058578:Biglycan; D018076:DNA, Complementary; D016326:Extracellular Matrix Proteins; D009124:Muscle Proteins; D011509:Proteoglycans