title: [A highly-productive attenuated variant of Japanese encephalitis virus].
abstract: Attenuated strain of Japanese encephalitis virus (JEV), clone 3, has been isolated from suckling mouse brain cell cultures chronically infected with JEV Nakayama strain, clone 33. Clone 3 actively replicates in 9-day chicken fibroblast cultures and possessed an uncommon for a JE agent capacity of causing cytodestruction of 1-2-day monolayer of chicken embryo cells, accumulates in these cultures in high titers (9.0 lg PFU/ml and higher), and is characterized by a high antigenic activity and a wide spectrum of antigenic relationships. New biologic properties acquired by JEV over the course of its persistence were retained after 10 and more passages through suckling mouse brain.
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: N V
authors.initials: NV
authors.lastname: Loginova
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D000956:Antigens, Viral / Q000276:immunology; D001921:Brain / Q000473:pathology / Q000821:virology; D002460:Cell Line; D002642:Chick Embryo; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D051379:Mice; D012692:Serial Passage
chemical_list: D000956:Antigens, Viral
vernacular_title: Vysokoproduktivnyĭ attenuirovannyĭ variant virusa Iaponskogo éntsefalit.