title: Extramammary Paget's disease: a report of 22 cases in Chinese males.
abstract: Extramammary Paget's disease (EMPD) is more frequently seen in Caucasian females than in males (3.2:1 female:male ratio). During the past 14 year period, we have collected 22 patients, all Chinese males, with EMPD. They presented with eczema-like lesions in the early stages in the genital or perianal regions. Histological sections showed Paget cells within the epidermis or skin appendages and even within the dermis. No underlying adnexal carcinoma or adjacent internal carcinoma could be detected after thorough examinations. Mode of therapy and outcome are presented. EMPD seems to affect more males than females in Orientals. The incidence of concomitant malignancy in Chinese male patients with genital Paget's disease seems to be much lower than that in Caucasians. However, if EMPD involves the glans penis or perianal area, a search for internal malignancy is still warranted.
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Chang
authors.forename: H N
authors.initials: HN
authors.lastname: Liu
authors.forename: C K
authors.initials: CK
authors.lastname: Wong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000628:therapy; D011379:Prognosis