title: [Antiphospholipid antibody syndrome as a possible cause of paresis in a child].
abstract: The Authors report on the case of a 4-year-old boy, admitted to the pediatric department for left hemiplegia. CT scan of the brain was negative on the day of admission but, on the following day, showed 3 small hypodense focal lesions in the posterior branch of the internal capsule, in the knee of the internal capsule and in the posterior parietal region of the cortex. The acute phase almost completely resolved in 10 days. Twenty days after presentation, cerebral angiography showed a thrombosis of an anterior, right perforating vessel, together with the hypoplasia of the horizontal portion of the cerebral anterior artery. The determination of anti-cardiolipin antibodies, even though performed far from the acute phase of the disease, showed a low IgG positivity. Two months after the onset the neurological symptoms completely resolved. In the presence of hypoplasia, narrowing and other lesions of cerebral vessel, it is possible to hypotesize that the occurrence of thrombotic fenomen, ascribable to anti-phaspholipid antibodies, is responsible for the neurological symptoms. The association of thrombosis and anti-phospholipid antibodies suggest that the assessment of anti-phospholipid antibodies should be routinely performed in the presence of thrombotic phenomena.
authors.affiliation: Divisione di Pediatria, Ospedale Civile di Morbegno, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Zecca
authors.forename: G
authors.initials: G
authors.lastname: Motti
authors.forename: C
authors.initials: C
authors.lastname: Manzoni
authors.forename: A
authors.initials: A
authors.lastname: Lazzaro
authors.forename: G
authors.initials: G
authors.lastname: Mattiuzzo
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D002533:Cerebral Angiography; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006429:Hemiplegia / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008297:Male; D010291:Paresis / Q000000981:diagnostic imaging / Q000209:etiology*; D013997:Time Factors
chemical_list: D017152:Antibodies, Antiphospholipid
vernacular_title: La "sindrome da anticorpi antifosfolipidi" come possible causa di una paresi in un bambino.