title: Simplified organ retention functions for physiologically based recycling biokinetic models.
abstract: Recent ICRP Publications on biokinetic models show a movement from simple schematic models to more complex, physiologically-based models. Such models require considerably greater computing resources to implement than their predecessors, effectively making them inaccessible to many users. Fortunately, retention in most of the compartments of these large recycling models can be adequately approximated by the sum of a few exponential functions compatible with the simple catenary models used almost exclusively in ICRP Publication 30. An eigenvalue method is used to solve the plutonium model of ICRP Publication 67 for intakes by inhalation, ingestion, and injection. The organ retention expressions so obtained are reduced by least squares minimization to functions consisting of the sum of a few exponential terms only. These simplified functions give committed doses accurate to within 5% and activities to within 10%. A similar treatment is used to obtain simplified expressions for daily excretion rates of plutonium.
authors.affiliation: NRPB, Chilton, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Khursheed
authors.forename: T P
authors.initials: TP
authors.lastname: Fell
authors.forename: G M
authors.initials: GM
authors.lastname: Kendall
authors.forename: A W
authors.initials: AW
authors.lastname: Phipps
mesh_terms: D008954:Models, Biological; D011005:Plutonium / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011835:Radiation Protection; D014018:Tissue Distribution
chemical_list: D011005:Plutonium