title: The ATPase module and the process of cellular immortalization.
abstract: The phenotype of normal aging is proposed to result from a progressive decrease in the functional capacity of the mitochondrion as the main supplier of the universal currency of bioenergy, ATP. It is suggested that this aging-related mitochondrial dysfunction specifically concerns the ATPase module of the ATP synthase enzyme complex. Evidence in support of this proposal is reviewed.
authors.affiliation: Department of Clinical Chemistry, Blekinge County Hospital, Karlskrona, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Krøoll
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism; D008928:Mitochondria / Q000378:metabolism*
chemical_list: D000251:Adenosine Triphosphatases