A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competitive environment.
A competition model describing tumor-normal cell interaction with the added effects of periodically pulsed chemotherapy is discussed. The model describes parameter conditions needed to prevent relapse following attempts to remove the tumor or tumor metastasis. The effects of resistant tumor subpopulations are also investigated and recurrence prevention strategies are explored.
Panetta
J C
JC
Department of Mathematics and Statistics, Old Dominion University, Norfolk, VA 23529, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002455:Cell Division; D004351:Drug Resistance; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence
D000970:Antineoplastic Agents