Influence of allogeneic blood transfusion on natural killer cell activity in burn-injured mice.
Allogeneic blood transfusion (Allo/BT) and burn injury modify the cellular immune response in patients under a variety of circumstances. We designed this study to investigate the influence of Allo/BT, burn injury, and the combination of the two on in vivo natural killer (NK) cell activity in a murine model. This study demonstrated significant enhancement of in vivo NK cell activity in noninjured BALB/c mice receiving Allo/BT from C3H mice when compared to both the control and syngeneic blood transfusion group at posttransfusion day 5. When burn-injured mice were compared to sham-stressed mice, the burn-injured mice showed significant suppression of in vivo NK cell activity. Furthermore, in this strain combination model, Allo/BT modulated the suppressive effect of burn injury on in vivo NK cell activity at posttransfusion day 5 and postburn day 7.
Winslow
G A
GA
Department of Surgery, University of Utah Medical Center, Salt Lake City 84132, USA.
Shelby
J
J
Nelson
E W
EW
Saffle
J R
JR
D000704:Analysis of Variance; D000818:Animals; D001803:Blood Transfusion; D002056:Burns / Q000276:immunology / Q000628:therapy*; D004195:Disease Models, Animal; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C