Nasopharyngeal carcinoma: Epstein-Barr Virus significance.
Thirty-one cases of NPC were investigated by in situ hybridization, PCR analysis and serology to assess the presence of EBV and to interrelate these findings. Statistical analysis showed a significant correlation between the probability of detecting EBV and NPC. There was no significant association between in situ hybridization, PCR and serology. Tumor size correlated with EBNA, but no correlation between smoking and NPC was found.
Kottaridis
S D
SD
Papanikolaou Research Center of Oncology, St. Savas Hospital, Athens, Greece.
Panotopoulou
E
E
Diamantis
I
I
Goula
I
I
Danilidis
J
J
Fountzilas
G
G
D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D002277:Carcinoma / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000821:virology*; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction
D000914:Antibodies, Viral; D007070:Immunoglobulin A