title: The nerve growth factor/tumor necrosis factor receptor family.
abstract: Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of approximately 40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with beta-strands that form a jelly-roll beta-sandwich. The receptors recognize soluble or cell-surface-bound ligands and mediate diverse cellular responses. Activation of intracellular signals is mediated at least in part by the association of proteins with a RING finger motif or a death domain to the cytoplasmic domains of the receptors. In addition to cell-membrane-bound receptors soluble forms have been described for most of the receptors. Activation of intracellular signals not only occurs through ligand binding to the receptors but cross-linking of at least some members of the ligand family can regulate cell functions.
authors.affiliation: Department of Medicine, School of Medicine, University of California, San Diego, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lotz
authors.forename: M
authors.initials: M
authors.lastname: Setareh
authors.forename: J
authors.initials: J
authors.lastname: von Kempis
authors.forename: H
authors.initials: H
authors.lastname: Schwarz
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000502:physiology; D019013:CD40 Antigens / Q000502:physiology; D003545:Cysteine; D006801:Humans; D017730:Ki-1 Antigen / Q000502:physiology; D008024:Ligands; D017433:Protein Structure, Secondary; D017475:Receptors, Nerve Growth Factor / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
chemical_list: D015703:Antigens, CD; D019013:CD40 Antigens; D017730:Ki-1 Antigen; D008024:Ligands; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D019014:fas Receptor; D003545:Cysteine