title: Hypolipidemic effect of garlic protein substituted for casein in diet of rats compared to those of garlic oil.
abstract: Garlic (Allium sativum Linn.) is ascribed with many therapeutic effects. For the present study, the water soluble proteins and the essential oil of garlic were investigated for their hypolipidemic effect on hyperlipidemia induced by cholesterol containing diet in albino rats. Both garlic protein (16% of diet) and garlic oil (100 mg/kg body weight/day) exhibited significant lipid lowering effects. The hypolipidemic action is primarily due to a decrease in hepatic cholesterogenesis in the treated rats. Even though garlic oil was found to be more effective, the garlic protein is more palatable and free from an obnoxious smell.
authors.affiliation: Department of Biochemistry, University of Kerala, Thiruvananthapuram, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Mathew
authors.forename: R S
authors.initials: RS
authors.lastname: Daniel
authors.forename: K T
authors.initials: KT
authors.lastname: Augusti
mesh_terms: D000498:Allyl Compounds; D000818:Animals; D004032:Diet; D005737:Garlic / Q000737:chemistry*; D008055:Lipids / Q000097:blood*; D008297:Male; D010938:Plant Oils / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D008055:Lipids; D010938:Plant Oils; D010940:Plant Proteins; D013440:Sulfides; C038491:allyl sulfide