[The role of heparin sulfate in the treatment of pregnant women with circulatory deficiency syndrome].
The syndrome from circulatory maternal, precocious and belated deficit could influence the appearance of a vast range of obstetric incluted pathology: recurrent abortions, delays of increase, pre-eclampsia, fetal and neonatal dead. The principal biochemical implicated mechanism has represented from alteration of equilibrium trombossano prostaciclina with adjunct vasoconstriction and uterum-placental hypoperfusion. In this study the authors have estimated the efficacy and the compliance of the heparan sulfate in 30 pregnant patients to risk for vascular pathology. In all these cases, the rational to the use the heparan sulfate had represented from the necessity to associate a therapy anteplatelet with associate an fibrinolitic activity. The percent of pregnancies with alive and vital fetuses was of the 90%; the collateral effects have been inconsiderable. The authors retain useful effect randomize checked studies to evaluate further the real results this therapy.
Palmeri
M A
MA
Centro Gynecos, Palermo.
Chianchiano
N
N
Simonaro
C
C
Perino
A
A
D000022:Abortion, Spontaneous / Q000150:complications* / Q000276:immunology; D000328:Adult; D000740:Anemia / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000209:etiology*; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G; D010298:Parity; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012008:Recurrence; D014689:Venous Insufficiency / Q000188:drug therapy / Q000209:etiology*
D007074:Immunoglobulin G; D006493:Heparin
Ruolo dell'eparan solfato nel trattamento di pazienti gravide con sindrome da deficit circolatorio.