Arthrogryposis multiplex congenita and bilateral parietal polymicrogyria in association with the intrauterine death of a twin.
A case of neurogenic arthrogryposis multiplex congenita (AMC) with associated neuronal migration abnormalities is described. A child with neurogenic AMC and developmental delay presented with late onset of seizures. The first trimester of the mother's pregnancy was marked by an episode of gastro-enteritis and the intrauterine death of a twin fetus. Computer tomography (CT) and magnetic resonance (MR) imaging demonstrated abnormal neuronal migration consisting of bilateral parietal polymicrogyria, and an isolated grey matter heterotopia.
Baker
E M
EM
Department of Neuroradiology, Newcastle General Hospital, UK.
Khorasgani
M G
MG
Gardner-Medwin
D
D
Gholkar
A
A
Griffiths
P D
PD
D017668:Age of Onset; D001176:Arthrogryposis / Q000150:complications* / Q000175:diagnosis; D002465:Cell Movement; D002648:Child; D002828:Choristoma / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005313:Fetal Death; D006801:Humans; D008279:Magnetic Resonance Imaging; D010296:Parietal Lobe / Q000002:abnormalities* / Q000503:physiopathology*; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014427:Twins