Partition coefficients by curve fitting: the use of two different octanol volumes in a dual-phase potentiometric titration.
It is shown that when two different volumes of the second phase are employed in a single dual-phase potentiometric titration, the partition coefficients of the most highly ionized species can be readily calculated by refinement of the parameters for the dual-purpose titration equations. Graphical comparison of the calculated titration curve with that obtained experimentally is helpful in making initial estimates of the parameters.
Clarke
F H
FH
ChemClarke, Inc., Califon, NJ 07830, USA.
Cahoon
N M
NM
D000143:Acids / Q000737:chemistry*; D008433:Mathematics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D017186:Titrimetry
D000143:Acids; D004364:Pharmaceutical Preparations; D011725:Pyridines