[Prospects of the use of a quantitative functional-morphological method in the evaluation of toxicity of chemical substances].
The article describes possible application of quantitative functional and morphologic analysis to evaluation of chemical toxicity. Alteration caused by low doses of chemicals was proved to be mediated by neuroendocrine system. The regulatory disorders result from compromised interaction of cellular elements composing blood-tissue barriers in endocrine organs. The alteration caused by toxic chemicals could be lowered through the use of physiologic stabilization of endocrine system. Criteria to evaluate chemical toxicity are suggested.
Popuchiyev
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D000311:Adrenal Glands / Q000187:drug effects; D004796:Clinical Enzyme Tests; D003592:Cytophotometry; D015386:Hazardous Substances / Q000633:toxicity*; D006651:Histocytochemistry; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D009489:Neurosecretion / Q000187:drug effects; D009490:Neurosecretory Systems / Q000187:drug effects; D018675:Toxicity Tests / Q000379:methods*
D015386:Hazardous Substances
Perspektivy ispol'zovaniia kolichestvennogo funktsional'no-morfolocigicheskogo metoda dlia otsenki toksichnosti khimicheskikh veshchestv.