Effects of follicle-stimulating hormone administration on oestradiol-induced cystic ovaries in guinea pigs.
A consistent defect in follicle-stimulating hormone (FSH) secretion is seen in humans with Polycystic Ovarian Syndrome (PCOS); therefore, we evaluated whether Metrodin (a highly purified urinary FSH) administration concurrent with cyst induction or following cyst induction inhibits estrogen-induced cyst development and augments ovarian follicular growth in an established guinea pig model. All animals in these studies received subcutaneous implants containing oestradiol-17 beta (E2)-filled Silastic capsules for a 48-hour period. Guinea pigs in study #1 were administered four 0.25 mL injections of FSH or placebo at twelve-hour intervals simultaneously with the E2 treatment; guinea pigs assigned to study #2 were administered four 0.25 mL injections of FSH or placebo at twelve-hour intervals following the induction of the cystic condition by E2. Exogenous FSH appears to negate cyst formation when superimposed upon the cyst-inducing agent (E2). Further, treatment with FSH augmented the number of mid-sized follicles in both paradigms. This study is the first to establish evidence of an anti-cystic effect of FSH in an animal model.
Campion
C E
CE
Department of Biological Sciences, University of Wisconsin-Milwaukee 53201, USA.
Trewin
A L
AL
Hutz
R J
RJ
D000818:Animals; D004195:Disease Models, Animal; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006168:Guinea Pigs; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D004958:Estradiol; D005640:Follicle Stimulating Hormone