Dacron-covered stent-grafts for the percutaneous treatment of carotid aneurysms: effectiveness and biocompatibility--experimental study in swine.
OBJECTIVE
To evaluate the short-term effectiveness and biocompatibility of Dacron-covered stent-grafts for percutaneous treatment of carotid aneurysms.


METHODS
In eight swine, nine aneurysms were created surgically in the common carotid artery. Percutaneous treatment was performed with Dacron-covered stent-grafts. Seven of eight swine underwent follow-up angiography at 2, 3, 4, and 5 weeks after stent implantation. Histologic examinations of tissue from the site of stent implantation were performed at the same intervals.


RESULTS
Initial closing off of the aneurysm was possible in all swine. Angiographic follow-up revealed patency of only one Dacron-covered stent-graft after 2 weeks. In six of seven swine, the stent was occluded on the follow-up angiogram. One of the swine died of unclear cause after 1 week. The stent-graft of this swine was not occluded. In all Dacron-covered stent-grafts, inflammatory reaction with granulocyte infiltration was found next to the Dacron material.


CONCLUSIONS
Primary treatment of carotid aneurysms with Dacron-covered stent-grafts is effective. However, the short-term patency rate is poor, which probably can be attributed to the limited biocompatibility of the Dacron cover. An acute inflammatory reaction against Dacron seems responsible for the poor patency rate.
Link
J
J
Department of Radiology, Christian-Albrechts-University of Kiel, Germany.
Feyerabend
B
B
Grabener
M
M
Linstedt
U
U
Brossmann
J
J
Thomsen
H
H
Heller
M
M
D015901:Angiography, Digital Subtraction; D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000473:pathology*; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011093:Polyethylene Terephthalates; D015642:Radiology, Interventional; D015607:Stents; D013552:Swine; D013997:Time Factors; D014654:Vascular Patency
D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates