[Gardner syndrome: diagnostic, clinical and genetic questions in the light of 2 case reports].
The authors on the base of two cases of Gardner's syndrome recently observed, proceed to a wide review of literature on this subject so as to stress the peculiar aspects of this syndrome, so complex and uncommon. The greatest emphasis is given to the role of genetics as regarding to diagnosis and screening programs, as well as to the more recent acquisitions about diagnosis, therapy and follow up of risk lesions, such as colorectal and duodenal adenomas, as well as of intrabdominal desmoid tumours, which, although not histologically malignant, may often influence prognosis negatively, because of their remarkable local invasiveness and tendency to recurrence.
Messinetti
S
S
Università di Roma La Sapienza, VI Cattedra di Patologia Chirurgica.
Del Porto
G
G
Giacomelli
L
L
Gagliarducci
E
E
Grammatico
P
P
Manno
A
A
Fabrizio
G
G
Finizio
R
R
Pulcini
A
A
Granai
A V
AV
D000328:Adult; D005260:Female; D005736:Gardner Syndrome / Q000175:diagnosis / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype; D014057:Tomography, X-Ray Computed
Sindrome di Gardner: problematiche diagnostiche, cliniche e genetiche alla luce di due casi clinici.