Aleppicatines A and B from Euphorbia aleppica.
Two new pentacyclic diterpene polyesters, aleppicatine A and B, have been isolated from the acetone extract of the whole plant of Euphorbia aleppica, in addition to five known cycloartane-type triterpenes (24-methylenecycloartanol, cyclolaudenol cycloart-25-en-3 beta-ol-24-one, cycloart-22-en-3 beta,25-diol and cycloart-25-en-3 beta,24-diol), scopoletin, kaempferol and 4-hydroxybenzoic acid and its methyl ether. The structures of the new compounds and their hydrolysis products have been extensively characterized by high-field NMR spectroscopic methods, including 2D NMR techniques.
Oksüz
S
S
Department of Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Gürek
F
F
Lin
L Z
LZ
Gil
R R
RR
Pezzuto
J M
JM
Cordell
G A
GA
D001943:Breast Neoplasms; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010936:Plant Extracts; D011471:Prostatic Neoplasms; D014421:Turkey
D001952:Bridged-Ring Compounds; D010936:Plant Extracts; C100514:aleppicatine A; C100515:aleppicatine B