title: A role for sialoadhesin-positive tissue macrophages in host resistance to lymphoma metastasis in vivo.
abstract: Sialoadhesin (SER) is a newly described macrophage-restricted adhesion molecule with a sequence similarity to CD22 on B cells and to myelin-associated glycoprotein on Schwann cells. We describe here a functional role of SER+ spleen macrophages in antigen processing and presentation to T lymphocytes. In two syngeneic murine tumour systems (ESb-MP and lacZ transduced ESbL T-lymphoma cells), the activation state of SER+ macrophages (tested by activity of marker enzymes adenosine deaminase and 5'-nucleotidase) correlated with the arrest of lymphoma metastasis. Furthermore, this macrophage subpopulation became activated upon anti-tumour immunization as well as upon adoptive transfer of immune T lymphocytes into tumour-bearing hosts. We suggest that in situ-activated SER+ macrophages contribute to host resistance against metastasis.
authors.affiliation: The Tumor Immunology Program, German Cancer Research Center, Heidelberg.
authors.forename: V
authors.initials: V
authors.lastname: Umansky
authors.forename: P
authors.initials: P
authors.lastname: Beckhove
authors.forename: M
authors.initials: M
authors.lastname: Rocha
authors.forename: A
authors.initials: A
authors.lastname: Krüger
authors.forename: P R
authors.initials: PR
authors.lastname: Crocker
authors.forename: V
authors.initials: V
authors.lastname: Schirrmacher
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015815:Cell Adhesion Molecules; D016219:Immunotherapy, Adoptive; D008223:Lymphoma / Q000276:immunology* / Q000628:therapy; D008264:Macrophages / Q000737:chemistry / Q000276:immunology*; D008562:Membrane Glycoproteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D011971:Receptors, Immunologic; D063267:Sialic Acid Binding Ig-like Lectin 1; D013154:Spleen / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D063267:Sialic Acid Binding Ig-like Lectin 1; C571167:Siglec1 protein, mouse