title: Alterations in the systemic acid-base status and blood gas dynamics during progressive hypocalcaemia in cow calves.
abstract: Hypocalcaemia, induced in cow calves by slow infusion of Na2EDTA for 6 hr, led to biphasic changes in acid-base status. Decrease in ionized plasma Ca2+ concentration upto 0.82 +/- 0.06 mmole 1(-1) was associated with metabolic alkalosis. Further decrease in ionized plasma Ca2+ concentration (0.61 +/- 0.09 mmole 1(-1)) led to metabolic acidosis, superimposed by a respiratory component. There was significant decrease in oxygen tension and saturation of arterial blood as well as impaired uptake of oxygen by peripheral tissues and pulmonary blood.
authors.affiliation: Department of Veterinary Physiology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Setia
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: R S
authors.initials: RS
authors.lastname: Kahlon
authors.forename: S S
authors.initials: SS
authors.lastname: Randhawa
mesh_terms: D000137:Acid-Base Imbalance / Q000209:etiology*; D000818:Animals; D001784:Blood Gas Analysis; D002417:Cattle; D018450:Disease Progression; D006996:Hypocalcemia / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D008297:Male