title: Synthesis and biological evaluation of new diisocyanide- and triisocyanide-99mTc complexes.
abstract: This paper describes the synthesis of four new polyisocyanides (three diisocyanides and one triisocyanide). The complexation of 99mTc with these ligands is also studied through chromatography and revealed the formation of hexacoordinated 99mTc+1 complexes. Finally, biodistributions of these complexes in mice are given and compared. Heart captations are lower than the ones with [99mTc(MIBI)6]+ but remain constant and a satisfactory lungs clearance, probably due to the metabolization of the ligands, is observed.
authors.affiliation: Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité LEDSS IV, Université Joseph Fourier, Grenoble, France.
authors.forename: N
authors.initials: N
authors.lastname: Chemin
authors.forename: A
authors.initials: A
authors.lastname: du Moulinet d'Hardemare
authors.forename: S
authors.initials: S
authors.lastname: Bouquillon
authors.forename: D
authors.initials: D
authors.lastname: Fagret
authors.forename: M
authors.initials: M
authors.lastname: Vidal
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006321:Heart / Q000000981:diagnostic imaging; D008024:Ligands; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D003486:Cyanides; D008024:Ligands; D015609:Organotechnetium Compounds