[Protective effect of salvianolic acid a on ischemia-reperfusion induced injury in isolated rat heart].
The protective effect of salvianolic acid A (Sal A) on cardiac ischemia-reperfusion induced injury was studied on the isolated rat heart. The results indicate that Sal A can reduce the occurence of ventricular fibrillation, decrease the cellular LDH leaking and reduce the concentration of lipid peroxidation product-MDA significantly in ischemia-reperfused cardiac tissue. The possible machenism in decreasing ischemia-reperfusion injury of Sal A was discussed.
Du
G H
GH
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Qiu
Y
Y
Zhang
J T
JT
D000818:Animals; D002109:Caffeic Acids / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000517:prevention & control
D002109:Caffeic Acids; D016166:Free Radical Scavengers; D007773:Lactates; D008315:Malondialdehyde; C066201:salvianolic acid A; D007770:L-Lactate Dehydrogenase