title: The Escherichia coli trigger factor.
abstract: E. coli trigger factor is an abundant cytosolic protein originally identified by its ability to maintain the precursor of a secretory protein in a translocation competent form. Recent studies shed new light on the function of this protein. Trigger factor was found to be a peptidyl-prolyl-cisltrans-isomerase capable of catalysing protein folding in vitro, to associate with nascent cytosolic and secretory polypeptide chains, and to cooperate with the GroEL chaperone in promoting proteolysis of an unstable polypeptide in vivo. These findings suggest roles for trigger factor in various folding processes of secretory as well as cytosolic proteins.
authors.affiliation: Zentrum für Molekulare Biologie, Universität Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Hesterkamp
authors.forename: B
authors.initials: B
authors.lastname: Bukau
mesh_terms: D000591:Amino Acid Isomerases / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D018834:Chaperonin 60 / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D018832:Molecular Chaperones / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D019696:Peptidylprolyl Isomerase; D012270:Ribosomes / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D018834:Chaperonin 60; D018832:Molecular Chaperones; D010455:Peptides; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase