title: Lung cancer surgery in elderly patients.
abstract: OBJECTIVE
  Bronchogenic carcinoma is the major cancer-related cause of death in patients aged 70 years and over, and its incidence is rising. The aim of our study was to compare the incidence and the prognostic effect of the parameters characterizing resected patients with non-small-cell lung cancer (NSCLC) when stratified by age. Of 283 NSCLC patients candidates to a long-term follow-up program and who underwent pulmonary resection in our Unit, 34 (12%) were older than 70 years.
  
  
  METHODS
  All patients had been preoperatively selected to exclude those with severe or multiple organ system disease and staged in accordance with the UICC classification.
  
  
  RESULTS
  When univariate and multivariate analyses were performed within the elderly group, exclusively epidermoid carcinoma and multiple tumor nodules emerged as independent poor prognostic factors (hazard risk, 5.77 and 7.33, respectively). In comparing the older and younger groups, a higher incidence of previous primary neoplastic disease (P = 0.001), epidermoid carcinoma (P < 0.05) and multiple tumor nodules (P < 0.001) was observed in the elderly. Postoperative death was similar (3% vs 4.8%) in the two age groups, as was survival expectancy when stratified by stage. However, univariate analysis showed that epidermoid carcinoma (P = 0.001) and pneumonectomy (P = 0.00001) had a worse outcome in the older early stage subset than in the younger group. When multivariate analysis was performed in all early stage patients, only lymph node involvement and multiple tumor nodules were independently related to survival (hazard risk, 1.82 and 3.76, respectively) and had a poor prognosis. In more advanced disease, elderly and younger patients had a similar outcome.
  
  
  CONCLUSIONS
  Our results confirm that a patient's advanced age is not a risk factor in deciding on pulmonary resection, at least for stage I and II NSCLC, and suggest that in all patients, irrespective of age, stage and histologic cell type, the presence of multiple tumor nodules is the only true prognostic factor with a very low survival rate.
authors.affiliation: 1st Department of Surgery, University of Rome, La Sapienza, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cangemi
authors.forename: P
authors.initials: P
authors.lastname: Volpino
authors.forename: N
authors.initials: N
authors.lastname: D'Andrea
authors.forename: M
authors.initials: M
authors.lastname: Puopolo
authors.forename: R
authors.initials: R
authors.lastname: Tomassini
authors.forename: R
authors.initials: R
authors.lastname: Cangemi
authors.forename: G
authors.initials: G
authors.lastname: Piat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D015996:Survival Rate