Cisapride toxicosis in dogs.
Cisapride is an oral prokinetic agent used to facilitate or restore motility in the gastrointestinal tract. The National Animal Control Center has received 17 reports of accidental overexposure of dogs to cisapride since 1994. Doses of 640 mg/kg in dogs were reported to be lethal, but severe clinical signs have been noted at acute exposures as low as 18 mg/kg. The most common signs include diarrhea, muscle tremors and fasciculations, ataxia and incoordination, and hyperthermia. Available treatment is symptomatic and supportive. Activated charcoal is effective in reducing plasma cisapride levels.
Volmer
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National Animal Poison Control Center, College of Veterinary Medicine, Urbana, IL 61801, USA.
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000506:poisoning* / Q000627:therapeutic use; D020117:Cisapride; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D004347:Drug Interactions; D062787:Drug Overdose / Q000628:therapy / Q000662:veterinary; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D010880:Piperidines / Q000493:pharmacokinetics / Q000494:pharmacology / Q000506:poisoning* / Q000627:therapeutic use; D011039:Poison Control Centers
D000897:Anti-Ulcer Agents; D010880:Piperidines; D020117:Cisapride