title: Pessoine and spinosine, two catecholic berbines from Annona spinescens.
abstract: The trunk bark and roots of Annona spinescens have been investigated for their alkaloid content. Two new berbine alkaloids, pessoine (1) and spinosine (2), have been isolated from the bark, and their structures were elucidated by spectroscopic methods. Eight known isoquinoline alkaloids were also obtained. The trypanocidal and antileishmanial activities of these isolated compounds have been investigated.
authors.affiliation: Laboratoire de Pharmacognosie, U.R.A. 1843 CNRS (BIOCIS), Faculté de Pharmacie. Chatenay-Malabry, France.
authors.forename: E F
authors.initials: EF
authors.lastname: Queiroz
authors.forename: F
authors.initials: F
authors.lastname: Roblot
authors.forename: A
authors.initials: A
authors.lastname: Cavé
authors.forename: M Q
authors.initials: MQ
authors.lastname: Paulo
authors.forename: A
authors.initials: A
authors.lastname: Fournet
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D001600:Berberine Alkaloids; D014344:Trypanocidal Agents; C100547:pessoine; C100548:spinosine