title: [Concomitant radiochemotherapy in locally advanced ORL cancers: a prospective study of 68 cases].
abstract: From January 1988 to July 1992, 68 patients presenting with a locally advanced and unresectable carcinoma of the head and neck region were given 3 to 5 courses of chemotherapy (5-FU 1 g/m2, day 1 to 3, cisplatin 4 mg/m2, day 1 and 2, 15 mg/m2 day 8) combined with simultaneous radiotherapy. Patients were enrolled in two protocols. In the initial one a 70 Gy total dose was delivered in 105 days, and in the latter the same dose was given in only 63 days. Toxicity was moderate and acceptable. In the 62 evaluable patients, a complete response was observed in 62%, and partial response in 24%. The complete response rate was higher (80%) in the population enrolled in the second protocol. Overall the median survival is 18 months. At 2 and 3 years, the overall survival is 48% and 30% respectively. These results suggest an influence of overall treatment duration on complete response rate and survival.
authors.affiliation: Service de cancérologie-radiothérapie, hôpital Saint-Louis, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Maylin
authors.forename: S
authors.initials: S
authors.lastname: Walter
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.forename: M D
authors.initials: MD
authors.lastname: Brette
authors.forename: C
authors.initials: C
authors.lastname: Durdux
authors.forename: J P
authors.initials: JP
authors.lastname: Monteil
authors.forename: A
authors.initials: A
authors.lastname: Deboise
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D015996:Survival Rate
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Radiochimiothérapie concomitante dans les cancers ORL localement avancés: étude prospective de 68 patients.