title: Induction of cyclooxygenase type-2 (COX-2) in rat endometrium at the peak of serum estradiol during the estrus cycle.
abstract: We investigated the induction of cyclooxygenase (COX) in rat endometrium during the estrus cycle. The estrus cycle was divided into five stages (proestrus, estrus, diestrus-1, diestrus-2, diestrus-3) by cytological observation of vaginal smears. COX-1 was detected in the endometrium during all five stages of the estrus cycle. In contrast, COX-2 in the endometrium was detectable only in three stages (diestrus-3, proestrus, estrus) and showed a peak at diestrus-3, coinciding with the peak in serum estradiol level, suggesting the estradiol-dependent induction of COX-2.
authors.affiliation: Department of Obstetrics and Gynecology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shoda
authors.forename: K
authors.initials: K
authors.lastname: Hatanaka
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Majima
authors.forename: M
authors.initials: M
authors.lastname: Ogino
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Nishijima
authors.forename: M
authors.initials: M
authors.lastname: Katori
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D004717:Endometrium / Q000378:metabolism; D004958:Estradiol / Q000097:blood* / Q000378:metabolism; D004971:Estrus / Q000378:metabolism*; D005260:Female; D015151:Immunoblotting; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004958:Estradiol; D011451:Prostaglandin-Endoperoxide Synthases