Picroliv protects against alcohol-induced chronic hepatotoxicity in rats.
Daily administration of ethyl alcohol (3.76 g/kg, p.o.) for 45 days resulted in significant changes in several biochemical parameters of the liver and serum of albino rats. After exposure to alcohol for 30 days when Picroliv (12 mg/kg, p.o.), an iridoid glycoside fraction of Picrorhiza kurroa, was administered for 15 days along with alcohol, the degree of change in most of the parameters was reduced.
Rastogi
R
R
Biochemistry Division, C.D.R.I., Lucknow, India.
Saksena
S
S
Garg
N K
NK
Kapoor
N K
NK
Agarwal
D P
DP
Dhawan
B N
BN
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002934:Cinnamates / Q000627:therapeutic use*; D000431:Ethanol / Q000633:toxicity; D006027:Glycosides / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts; D010946:Plants, Medicinal; D051381:Rats; D014641:Vanillic Acid / Q000627:therapeutic use*
D000975:Antioxidants; D002934:Cinnamates; D006027:Glycosides; D010936:Plant Extracts; C057463:kutkin; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+); D014641:Vanillic Acid