title: Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.
abstract: OBJECTIVE
  The authors' goal was to determine whether either of two 5-HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response.
  
  
  METHODS
  Brief Psychiatric Rating Scale (BPRS) ratings were obtained in 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis.
  
  
  RESULTS
  Neither 102-T/C nor 452-His/Tyr was associated with clozapine response. There were no significant differences in BPRS scores among patients with different 5-HT2A genotypes at week 10 of clozapine administration.
  
  
  CONCLUSIONS
  Allelic variation in the 5-HT2A gene is not associated with individual differences in clozapine response.
authors.affiliation: Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892-13880, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Malhotra
authors.forename: D
authors.initials: D
authors.lastname: Goldman
authors.forename: N
authors.initials: N
authors.lastname: Ozaki
authors.forename: A
authors.initials: A
authors.lastname: Breier
authors.forename: R
authors.initials: R
authors.lastname: Buchanan
authors.forename: D
authors.initials: D
authors.lastname: Pickar
mesh_terms: D000328:Adult; D000483:Alleles; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D003024:Clozapine