title: Variation in response of human skin to irritant challenge.
abstract: A major obstacle to the establishment of a protocol for in vivo irritant skin testing in humans is the apparent variability of responses between individuals. This study of the threshold response of normal human skin to a standard irritant (sodium lauryl sulfate 0.3-10%), in a group of 22 subjects, revealed a marked interindividual variation in their threshold reaction. The results demonstrate that this phenomenon does exist and that it will have to be allowed for in future human irritant test systems or assays.
authors.affiliation: St. John's Insitute of Dermatology, St. Thomas's Hospital, London, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Judge
authors.forename: H A
authors.initials: HA
authors.lastname: Griffiths
authors.forename: D A
authors.initials: DA
authors.lastname: Basketter
authors.forename: I R
authors.initials: IR
authors.lastname: White
authors.forename: R J
authors.initials: RJ
authors.lastname: Rycroft
authors.forename: J P
authors.initials: JP
authors.lastname: McFadden
mesh_terms: D000328:Adult; D000368:Aged; D017453:Dermatitis, Irritant / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012016:Reference Values; D012867:Skin / Q000187:drug effects / Q000276:immunology; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D012967:Sodium Dodecyl Sulfate