[A comparative analysis of the effects of the systemic and intraventricular administration of serotonin antibodies on the behavioral reactions and nociceptive sensitivity in animals].
The antibodies to serotonin modulate behavioural reactions of animals depending on the mode of administration (intracerebroventricular or intraperitoneal) and the testing time. Intraventricular injection induces inhibition of behavioural activity within 1--2 hours. Systemic injection produces a biphasic effect on the serotoninergic system, i. e., the activation in the early period and the steady inhibition later. Effects of the intraperitoneally injected serotonin antibodies on the CNS are probably mediated either by serotonin binding in blood or by involvement of neurotrophic factors of the immune system. Both ways of administration of the serotonin antibodies result in late hyperalgesia.
Evseev
V A
VA
Basharova
L A
LA
Vetrilé
L A
LA
Trekova
N A
NA
Mikovskaia
O I
OI
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage* / Q000302:isolation & purification / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D007114:Immunization / Q000379:methods; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000008:administration & dosage; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000276:immunology*; D013997:Time Factors; D005719:gamma-Globulins / Q000008:administration & dosage
D000906:Antibodies; D005719:gamma-Globulins; D012701:Serotonin; D009020:Morphine
Sravnitel'nyĭ analiz éffektov sistemnogo i vnutrizheludochkovogo vvedeniia antitel k serotoninu na povedencheskie reaktsii i notsitseptivnuiu chuvstvitel'nost' zhivotnykh.