title: [Comparative characteristics of a test system for detecting antibodies to hepatitis C virus].
abstract: The sensitivities and specificities of enzyme immunoassay (EIA) kits for the detection of antibodies to hepatitis C virus (HCV) were compared in donor blood screening. A total of 3308 donors were examined using Akvapast immunodiagnosticum (St. Petersburg), lot 12. Anti-HCV antibodies were detected in 43 (1.3%) subjects. Blood sera of these donors were additionally investigated using other lots of Akvapast, Hepascan (Bioservice, Moscow), Blot-0.5 (Bioservice, Moscow), and immunoComb (France). The studies demonstrated that none of the agents used can be acknowledged as ideally sensitive and specific for the detection of anti-HCV antibodies. Maximally sensitive diagnostic kits should be preferred for the screening of donors of blood components and for other mass surveys. Highly-specific test systems are advisable for profound examinations and diagnostic monitoring. The creation of a system of reference and expert diagnosis of hepatitis C remains a pressing task.
authors.forename: E B
authors.initials: EB
authors.lastname: Zhiburt
authors.forename: N V
authors.initials: NV
authors.lastname: Bel'gesov
authors.forename: V V
authors.initials: VV
authors.lastname: Danil'chenko
authors.forename: N B
authors.initials: NB
authors.lastname: Serebrianaia
authors.forename: V K
authors.initials: VK
authors.lastname: Potepun
authors.forename: S V
authors.initials: SV
authors.lastname: Sidorkevich
authors.forename: V B
authors.initials: VB
authors.lastname: Vasiliuk
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Zhuravlev
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005069:Evaluation Studies as Topic; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
chemical_list: D018937:Hepatitis C Antibodies; D011933:Reagent Kits, Diagnostic
vernacular_title: Sravnitel'naia kharakteristika test-sistem dlia opredeleniia antitel k virusu gepatita C.