title: [Intraventricular morphine administration as a treatment possibility for patients with intractable pain].
abstract: The treatment of intractable pain, especially in cancer patients, often sets problems to patient and therapist. While epidural and intrathecal spinal administration of opiates is a routine treatment in pain with a sub-diaphragmatic topography it is almost ineffective in cervicocephalic or thoracic cancer. An alternative here is the administration of morphine into the lateral or third ventricle by a catheter-reservoir system. We report on our experience in the treatment of twenty patients, mostly suffering from cancer (18 cases), from 1990 to 1993. It is shown to be an effective, non-destructive method with minimal side effects in the treatment of nociceptive pain. Analgesia takes effect within a few minutes and the necessary doses are low. Our results agree with those of other authors describing good to excellent results in 95% of patients with somatogenic pain. However, no or only minimal effect is achieved in the treatment of neurogenic pain by intracerebroventricular morphine therapy.
authors.affiliation: Neurochirurgische Universitätsklinik, AKH Wien.
authors.forename: M
authors.initials: M
authors.lastname: Seiwald
authors.forename: F
authors.initials: F
authors.lastname: Alesch
authors.forename: A
authors.initials: A
authors.lastname: Kofler
mesh_terms: D001921:Brain / Q000187:drug effects*; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009369:Neoplasms / Q000503:physiopathology*; D010147:Pain Measurement; D010148:Intractable Pain / Q000188:drug therapy*; D013238:Stereotaxic Techniques / Q000295:instrumentation; D014696:Ventriculostomy / Q000295:instrumentation*
chemical_list: D009020:Morphine
vernacular_title: Intraventrikuläre Morphingaben als Behandlungsmöglichkeit bei Patienten mit nicht beherrschbaren Schmerzen.