title: Intestinal perforation in temporal arteritis, associated with paroxysmal nocturnal hemoglobinuria.
abstract: Temporal arteritis (TA) is an adult-onset, focal granulomatous inflammatory disorder of the small and medium sized arteries. Intestinal perforation is a rare complication of TA. Regarding its etiology, steroid-induced or arteritis-induced ulceration have been proposed. We describe a patient who developed TA in addition to preceding paroxysmal nocturnal hemoglobinuria. During steroid therapy for TA, intestinal perforation manifested, and it was proven to be arteritis induced perforation on histological examinations. The patient may be the 5th reported case of TA complicated with arteritis-induced intestinal perforation. The possibility of polyangitis overlap syndrome of TA and polyarteritis nodosa is discussed.
authors.affiliation: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Tsuyuoka
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: E
authors.initials: E
authors.lastname: Shinoda
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: K
authors.initials: K
authors.lastname: Nishibe
authors.forename: E
authors.initials: E
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D013700:Giant Cell Arteritis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone