title: Validation of an algorithm for oral anticoagulant dosing and appointment scheduling.
abstract: Computer clinical decision-support systems require validation before clinical use. This study compared recommendations on warfarin dosage adjustment and timing of the next appointment made by an algorithm with those made by experienced and inexperienced clinicians. Data abstracted from the records of 125 patients seen regularly in the anticoagulant clinic were used. The algorithm recommended dose changes and next appointment for cases with INRs between 1.8 to 4.2 (therapeutic range 2.0-3.0) and between 2.3 to 5.3 (therapeutic range 3.0-4.5). Beyond these values the algorithm referred the cases to "see doctor'. Compared to experienced clinicians, the algorithm was better at "recognising' difficult patients than inexperienced clinicians (kappa = 0.43 and 0.32 respectively). There was no statistically significant difference between all decision makers in dosage recommendations for the non-difficult cases, but there was much more variation amongst the inexperienced clinicians. The interval recommendations were statistically different between and within the different decision-makers. The inexperienced clinicians tended to give relatively longer intervals for a given dose change. In conclusion, the algorithm performs better than inexperienced clinicians and as well as experienced clinicians for the non-difficult cases.
authors.affiliation: Department of Cardiology, Whittington Hospital Highgate Hill, London, UK.
authors.forename: B D
authors.initials: BD
authors.lastname: Vadher
authors.forename: D L
authors.initials: DL
authors.lastname: Patterson
authors.forename: M S
authors.initials: MS
authors.lastname: Leaning
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D000925:Anticoagulants / Q000008:administration & dosage*; D001071:Appointments and Schedules; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D011364:Professional Practice; D011446:Prospective Studies; D015203:Reproducibility of Results; D013813:Therapy, Computer-Assisted; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D014859:Warfarin