title: Relationship of interleukin-8 and colony-stimulating factors to neutrophil migration in aseptic meningitis.
abstract: Polymorphonuclear neutrophilic leucocyte (PMNL) migration into the subarachnoid space in aseptic meningitis of probable enteroviral aetiology was evaluated in relation to cerebrospinal fluid and serum levels of interleukin-8 (IL-8), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). IL-8 levels reached a plateau within 12h of onset, while M-CSF and G-CSF levels reached a peak between 12 and 24 h after onset, corresponding to the peak increase in PMNL count. G-CSF levels had the closest correlation with PMNL count. M-CSF levels were weakly correlated with PMNL count. IL-8 levels were not correlated with PMNL count except within 12 h of onset. IL-8 and G-CSF were detected predominantly in cerebrospinal fluid, while the M-CSF levels in the two compartments were not different except between 12 and 24 h after onset. It is considered that IL-8 triggers rapid and transient migration of PMNL, and that G-CSF then promotes gradual and consistent infiltration of PMNL.
authors.affiliation: Department of Paediatrics, Okayama University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: S
authors.initials: S
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000293:Adolescent; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D016173:Macrophage Colony-Stimulating Factor / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008582:Meningitis, Aseptic / Q000276:immunology* / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology*; D013997:Time Factors
chemical_list: D016209:Interleukin-8; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor