Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16.
Two clones containing nonfunctional pseudogenes for the human uracil-DNA glycosylase gene have been isolated. The sequences of the two clones that are homologous to the UNG cDNA span 670 and 580 bp, respectively. In the longest of these, a full length Sx type Alu sequence interrupts the homologous sequence. Chromosomal mapping locates the clones to chromosomes 16 and 14. Comparison of the pseudogene sequences to the cDNA sequence indicates that the pseudogenes diverged from the functional gene approximately 31 and 22 million years ago, which is before the point in evolution when great apes and hominides separated.
Lund
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UNIGEN Center for Molecular Biology, Norwegian University for Science and Technology, Trondheim, Norway.
Eftedal
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Haug
T
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Krokan
H E
HE
D001483:Base Sequence; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002885:Chromosomes, Human, Pair 16; D003001:Cloning, Molecular; D045647:DNA Glycosylases; D018076:DNA, Complementary; D015723:Gene Library; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D009699:N-Glycosyl Hydrolases / Q000235:genetics*; D011544:Pseudogenes; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013995:Time; D051981:Uracil-DNA Glycosidase
D018076:DNA, Complementary; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase