[Hypothyroidism following radiosurgical treatment of cancers of the hypopharynx].
In a series of 224 patients treated between 1980 and 1992 for hypopharyngeal carcinoma by surgery and post postoperative radiotherapy we found an overall 54% incidence of elevated TSH levels. Decreased FT4 levels were associated in about one-third of the patients. When thyroidectomy was performed, 71% of the patients developed thyroid dysfunction. Most TSH abnormalities (45%) occurred within two years of treatment. Nevertheless, long-term followup is indicated since those complications may be delayed. Hormonal replacement therapy is recommended for patients with elevated TSH.
Jung
G M
GM
Département de radiothérapie, Strasbourg, France.
Wagner
J P
JP
Ernest
O
O
Schneegans
O
O
Gentine
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D007037:Hypothyroidism / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology / Q000528:radiation effects / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood
D013972:Thyrotropin
Hypothyroïdie après traitement radiochirurgical des cancers de l'hypopharynx.