title: [Incidence of chronic obstructive respiratory tract disease in patients with obstructive sleep apnea].
abstract: Data concerning the occurrence of chronic-obstructive pulmonary disease (COPD) in patients with obstructive sleep apnea syndrome (OSAS) vary between 11 and 20% due to the underlying definition of COPD. We investigated the frequency of COPD in 202 patients with OSAS. The obstructive pattern was defined by bodyplethysmography (Rt > 0.35 kPa x 1(-1) x s(-1)), flow-volume-curve (MEF50 < 50% pred.), Tiffeneau-index (FEV1/IVC < 70% pred.) and anamnesis (cough and/or sputum). Prevalence of COPD in our 202 patients with OSAS was 16.3%. Patients with OSAS and COPD had a higher body-mass-index (BMI), lower PaO2 and spent more time in an oxygen saturation < or = 90% in relation to total recording time (t90). Polysomnographically there was no difference between the two groups with regard to the ventilatory parameters apnea-index (AI) and apnea-hypopnea-index (AHI). As there is a high risk of developing hypercapnia, pulmonary arterial hypertension and cor pulmonale in patients with OSAS and COPD there is need for early diagnosis of the combination of both diseases.
authors.affiliation: Berufsgenossenschaftliche Kliniken Bergmannsheil, Medizinische Klinik und Poliklinik, Abteilung für Pneumologie, Allergologie und Schlafmedizin, Bochum.
authors.forename: M
authors.initials: M
authors.lastname: Orth
authors.forename: K
authors.initials: K
authors.lastname: Rasche
authors.forename: T T
authors.initials: TT
authors.lastname: Bauer
authors.forename: H W
authors.initials: HW
authors.lastname: Duchna
authors.forename: P
authors.initials: P
authors.lastname: Kollhosser
authors.forename: G
authors.initials: G
authors.lastname: Schultze-Werninghaus
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000453:epidemiology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010991:Plethysmography; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D010100:Oxygen
vernacular_title: Häufigkeit der chronisch-obstruktiven Atemwegserkrankung bei Patienten mit obstruktivem Schlafapnoesyndrom.