title: Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia.
abstract: Sixty-two patients with schizophrenia and 96 normal controls were investigated for genetic association with restriction fragment length polymorphisms (RFLPs) in the serotonin receptor genes. A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor gene. The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTR2A on the long arm of chromosomes 13.
authors.affiliation: Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inayama
authors.forename: H
authors.initials: H
authors.lastname: Yoneda
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: Y
authors.initials: Y
authors.lastname: Nonomura
authors.forename: Y
authors.initials: Y
authors.lastname: Kono
authors.forename: R
authors.initials: R
authors.lastname: Takahata
authors.forename: J
authors.initials: J
authors.lastname: Koh
authors.forename: J
authors.initials: J
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Takai
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
authors.forename: H
authors.initials: H
authors.lastname: Asaba
mesh_terms: D000328:Adult; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D017931:DNA Primers; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D004247:DNA