title: Two new taxoids from the stem bark of Taxus baccata.
abstract: Two new taxoids, 13-deoxo-13 alpha-acetyloxy-7 beta,9 alpha-diacetyl-1,2-dideoxytaxine B[1] and 7 beta-xylosyl-10-deacetyltaxol D [7], were isolated from the stem bark of Taxus baccata cv. stricta. Their structures were elucidated using spectroscopic methods and their bioactivity was evaluated using an in vitro microtubule assembly assay.
authors.affiliation: Pharmaceutical Institute, Université Libre de Bruxelles, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: B
authors.initials: B
authors.lastname: Diallo
authors.forename: M
authors.initials: M
authors.lastname: Jaziri
authors.forename: R
authors.initials: R
authors.lastname: Vanhaelen-Fastré
authors.forename: M
authors.initials: M
authors.lastname: Vanhaelen
authors.forename: R
authors.initials: R
authors.lastname: Ottinger
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013552:Swine; D043823:Taxoids; D014404:Tubulin / Q000096:biosynthesis
chemical_list: C100477:13-deoxo-13-acetyloxy-7,9-diacetyl-1,2-dideoxytaxine; C100478:7-xylosyl-10-deacetyltaxol; D043823:Taxoids; D014404:Tubulin; D017239:Paclitaxel