Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial.
The objective of this study was to compare the efficacy of flutamide and cyproterone acetate in the treatment of hirsutism. Twenty-two women with idiopathic hirsutism were randomized to receive either flutamide or cyproterone acetate. Each patient underwent a complete gynecological examination as well as an endocrinological profile and hematological, hepatic and renal function analyses. Hirsutism scores were determined using a modified Ferriman-Gallwey scoring system. These tests were then repeated at 3 and 9 months of therapy. Eleven patients received 250 mg of flutamide twice daily and 11 patients received 100 mg of cyproterone acetate on days 5-14 of the menstrual cycle. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. There was a trend towards a better response with flutamide, that did not achieve significance. Another significant difference was the increased sex hormone-binding globulin in both groups. A statistically significant decrease was also observed for the levels of testosterone on both drugs. No subject withdrew from the study due to a side-effect. The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamide is a safe, well-tolerated and effective alternative in treatment.
Grigoriou
O
O
Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Papadias
C
C
Konidaris
S
S
Antoniou
G
G
Karakitsos
P
P
Giannikos
L
L
D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D003534:Cyproterone / Q000627:therapeutic use*; D005260:Female; D005485:Flutamide / Q000627:therapeutic use*; D006628:Hirsutism / Q000188:drug therapy*; D006728:Hormones / Q000097:blood; D006801:Humans; D011446:Prospective Studies
D000726:Androgen Antagonists; D006728:Hormones; D005485:Flutamide; D003534:Cyproterone