Modelization of coordinated changes of adenylate energy charge and ATP/ADP ratio: application to energy metabolism in invertebrate and vertebrate skeletal muscle.
Regulation of the coordinated adenylate energy charge (AEC) and ATP/ADP ratio variations was studied with the aid of computer-made simulations. When the equilibrium state for the adenylate kinase-catalyzed reaction has been assumed, the function describing the coordinated AEC and ATP/ADP ratio variations can be simply derived from the formulas describing these 2 parameters. The model was used to analyze incidence of AMP deamination in the coordinated regulation of cellular energy metabolism.
Raffin
J P
JP
Laboratoire de biotechnologie des micro-organismes hydrothermaux, Collège de France, Concarneau, France.
Thébault
M T
MT
D000659:AMP Deaminase / Q000493:pharmacokinetics; D000244:Adenosine Diphosphate / Q000032:analysis*; D000249:Adenosine Monophosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000032:analysis*; D000263:Adenylate Kinase / Q000493:pharmacokinetics; D000818:Animals; D003198:Computer Simulation; D004734:Energy Metabolism; D006801:Humans; D007448:Invertebrates / Q000378:metabolism; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism*; D051381:Rats; D014714:Vertebrates / Q000378:metabolism
D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000263:Adenylate Kinase; D000659:AMP Deaminase