The helix-loop-helix gene SCL: implicated in T-cell acute lymphoblastic leukaemia and in normal haematopoietic development.
The SCL gene encodes a member of the helix-loop-helix family of transcription factors and was first identified through its involvement in a chromosomal translocation in a human leukaemic cell line. SCL is now recognized to be aberrantly expressed in most human T-cell leukaemias. In around 25% of cases SCL overexpression is associated with identifiable chromosomal abnormalities but in other cases the mechanism of ectopic expression has not yet been identified. SCL is normally expressed in haematopoietic progenitor cells, erythroid cells, mast cells and megakaryocytes. Gene delivery experiments using haematopoietic cell lines and the recent creation of mice with a null mutation of the SCL gene have demonstrated that SCL plays a crucial role in haematopoietic commitment and differentiation.
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Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Begley
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CG
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D004268:DNA-Binding Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D018257:Helix-Loop-Helix Motifs; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics*; D051379:Mice; D009857:Oncogenes; D011518:Proto-Oncogene Proteins; D012016:Reference Values; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors; C489366:Tal1 protein, mouse; C067143:TAL1 protein, human