title: Different clinical outcome in coronary artery bypass with single and sequential vein grafts: a fifteen-year follow-up study.
abstract: OBJECTIVE
  In trying to answer the question about the controversial use of sequential grafts, we determined the long-term clinical outcome of patients in whom coronary artery bypass was done with different types of vein grafts.
  
  
  METHODS
  A total of 428 consecutive patients who underwent isolated coronary artery bypass with vein grafts between April 1, 1976, and April 1, 1977, were prospectively observed. In these patients three groups could be defined with single grafts only, sequential grafts only, and combined single and sequential grafts. Follow-up was 99.8% complete and averaged 15.4 years for the survivors. The Kaplan-Meier method and multivariate analysis done with the Cox regression model were used for survival, myocardial infarction, reintervention, and "any event."
  
  
  RESULTS
  Perioperative mortality and perioperative myocardial infarction rate were not statistically different among the three groups. During follow-up more myocardial infarctions (hazard ratio: 2.06; 95% confidence interval: 1.08 to 3.93; p = 0.0293) or any events (hazard ratio: 1.54; 95% confidence interval; 1.01 to 2.36; p = 0.0450) occurred in patients with sequential grafts only than in patients with single grafts only.
  
  
  CONCLUSIONS
  Although more complete revascularization was obtained in patients with sequential vein grafts only, more events during a 15-year follow-up occurred in these patients than in patients with single vein grafts only.
authors.affiliation: Department of Cardiology, Diaconessenhuis, Eindhoven, The Netherlands.
authors.forename: B L
authors.initials: BL
authors.lastname: van Brussel
authors.forename: H W
authors.initials: HW
authors.lastname: Plokker
authors.forename: A A
authors.initials: AA
authors.lastname: Voors
authors.forename: J M
authors.initials: JM
authors.lastname: Ernst
authors.forename: J C
authors.initials: JC
authors.lastname: Kelder
authors.forename: P J
authors.initials: PJ
authors.lastname: Knaepen
authors.forename: F E
authors.initials: FE
authors.lastname: Vermeulen
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass / Q000379:methods* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000209:etiology; D011183:Postoperative Complications; D012307:Risk Factors; D016896:Treatment Outcome