title: [Functional significance of CD56 large granular lymphocytes in the decidua in early pregnancy in the human].
abstract: OBJECTIVE
  The study was undertaken to characterize the large granular lymphocytes (LGL) found in large numbers in the decidua of early pregnancy, in order to investigate their functional significance in placentation.
  
  
  METHODS
  The LGL were investigated by immunohistochemical, flow cytometric and molecular biological techniques.
  
  
  CONCLUSIONS
  The LGL resemble a small subpopulation of Natural Killer cells (NK-cells) in the peripheral blood, express activation antigens and produce cytokines that may have a regulatory/modulatory influence on trophoblast growth.
authors.affiliation: Frauenklinik, Kinderklinik der Eberhard-Karls-Universität Tübingen.
authors.forename: K
authors.initials: K
authors.lastname: Marzusch
authors.forename: P
authors.initials: P
authors.lastname: Ruck
authors.forename: R
authors.initials: R
authors.lastname: Handgretinger
authors.forename: J
authors.initials: J
authors.lastname: Dietl
authors.forename: H P
authors.initials: HP
authors.lastname: Horny
authors.forename: E
authors.initials: E
authors.lastname: Kaiserling
mesh_terms: D019002:CD56 Antigen / Q000032:analysis*; D016207:Cytokines / Q000378:metabolism; D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007694:Killer Cells, Natural / Q000276:immunology*; D010929:Placentation / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000276:immunology
chemical_list: D019002:CD56 Antigen; D016207:Cytokines
vernacular_title: Zur funktionellen Bedeutung der CD56++ Large Granular Lymphocytes (LGL) in der Dezidua der Frühschwangerschaft beim Menschen.