Occurrence of nitro and non-nitro benzenoid musk compounds in human adipose tissue.
Nitro benzenoid musk compounds (Musk tibetene [CAS no. 145-39-1], Musk ambrette [83-66-9], Musk moskene [116-66-5], Musk ketone [81-14-1] and Musk xylene [81-15-2]) and non-nitro benzenoid musks (Celestolide [13171-00-1], Galaxolide [1222-05-5]) and Fixolide [1506-02-1] [21445-77-7] were analysed in 15 human adipose tissue samples from Switzerland by gas chromatography/high resolution mass spectrometry. The levels of Musk xylene and Galaxolide ranged up to 288 ng/g lipids and 171 ng/g lipids, respectively. The concentrations of non-nitro benzenoid musks found in human adipose tissue raise concern since very few toxicological data are available.
Müller
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S
Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland.
Schmid
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P
Schlatter
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C
D000273:Adipose Tissue / Q000737:chemistry*; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001555:Benzene Derivatives / Q000032:analysis*; D001578:Benzopyrans / Q000032:analysis; D002102:Cadaver; D002675:Child, Preschool; D002850:Chromatography, Gel; D004136:Dinitrobenzenes / Q000032:analysis; D004781:Environmental Exposure; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007189:Indans / Q000032:analysis; D008055:Lipids / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis; D010476:Perfume / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis; D014992:Xylenes / Q000032:analysis
D001555:Benzene Derivatives; D001578:Benzopyrans; D004136:Dinitrobenzenes; D007189:Indans; D008055:Lipids; D009153:Mutagens; D010476:Perfume; D014874:Water Pollutants, Chemical; D014992:Xylenes; C033118:acetyl tert-butyl dimethylindan; C033119:galaxolide; C042842:musk tibetine; C042841:moskene; C031447:musk xylene; C031448:musk ketone; C020422:musk ambrette (artificial)