title: [Hematological stability under ubenimex monotherapy in a patient with acute myelogenous leukemia developing marrow karyotypic changes during the course].
abstract: We encountered a 71-year-old female with acute myelogenous leukemia (AML, M1), who maintained a steady hematological state for 22 months under ubenimex monotherapy. At the first medical examination in our hospital, the marrow cellularity was approximately 40% containing leukemic myeloblasts of 41.4% in the total nucleated cells, and the marrow cytogenetic study revealed 47, XX, + 8 in 13 of 20 cells analyzed. Nineteen months later, the bone marrow showed definite hypoplasia with leukemic blasts of 39.8% and chromosome finding of 46, XX, ins (10;?) (q11;?) in all cells analyzed. During the course, the patient has been doing well without transfusion of red blood cells or platelets.
authors.affiliation: Hematology Division, School of Medicine Iwate Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimosegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Sugawara
authors.forename: H
authors.initials: H
authors.lastname: Numaoka
authors.forename: H
authors.initials: H
authors.lastname: Oikawa
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Utsugisawa
authors.forename: K
authors.initials: K
authors.lastname: Murai
authors.forename: Y
authors.initials: Y
authors.lastname: Narigasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Miyairi
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001854:Bone Marrow Cells; D002879:Chromosomes, Human, Pair 10; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D007930:Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D016254:Mutagenesis, Insertional; D014314:Trisomy
chemical_list: D000903:Antibiotics, Antineoplastic; D007930:Leucine; C012211:ubenimex