[Immunomodulating properties of synthetic fragments of human interleukin-2].
For the study of the antigenic structure and function of human interleukin 2, the peptides corresponding to its 60-72 sequence were synthesized by conventional methods of peptide chemistry in solution. To enhance the stability of the synthetic peptides towards the proteolysis and to remove their terminal charges, we acetylated their NH2 groups and esterified with methanol their carboxyls. Some of these peptides were converted from being cytotoxic to possessing strong growth-stimulating activity for the preliminary activated macrophages both in vitro and in vivo. The biologically active peptides were also shown to enhance regeneration-reparation processes in liver and skin.
Onoprienko
L V
LV
Mikhaleva
I I
II
Ivanova
V T
VT
Voĭtenkov
B O
BO
Okulov
V B
VB
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000595:Amino Acid Sequence; D006801:Humans; D007376:Interleukin-2 / Q000737:chemistry / Q000494:pharmacology*; D008115:Liver Regeneration; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D012038:Regeneration; D012879:Skin Physiological Phenomena; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D010446:Peptide Fragments
Immunomoduliruiushchie svoĭstva sinteticheskikh fragmentov interleĭkina-2 cheloveka.