The features of peripheral nerve lesions in young and adult rabbits after vincristine administration.
The comparison of neuropathological picture of vincristine induced neuropathy immediately after the end of its administration and after three months of survival was performed. The adult rabbits and six litters of newborns received vincristine once a week in increasing doses 0.05-0.25 mg/kg of body weight. The early changes consisted in degeneration of axons and myelin sheaths and lesions of the Schwann cells. The features of changes allow to suspect that vincristine may induce, in addition to the well known primary axonal damage, a toxic effect on the Schwann cells with secondary damage of myelin sheaths. The changes were more severe in adults than in young animals. The observations after three months of survival allow to think that the administered doses of vincristine did not impede the improvement when treatment was interrupted.
Dambska
M
M
Laboratory of Developmental Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warszawa.
Muzylak
M
M
Maślińska
D
D
D000367:Age Factors; D000375:Aging / Q000473:pathology; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D012583:Schwann Cells / Q000187:drug effects* / Q000648:ultrastructure; D014750:Vincristine / Q000633:toxicity*
D014750:Vincristine