title: Isolation of novel saquayamycins as inhibitors of farnesyl-protein transferase.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Sekizawa
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: J
authors.initials: J
authors.lastname: Yamaizumi
authors.forename: K
authors.initials: K
authors.lastname: Umezawa
mesh_terms: D000190:Actinomyces; D019883:Alkyl and Aryl Transferases; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014166:Transferases / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000187:drug effects; D000095602:Angucyclines and Angucyclinones
chemical_list: D019883:Alkyl and Aryl Transferases; D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D014166:Transferases; D018631:ras Proteins; C100407:saquayamycin E; D000095602:Angucyclines and Angucyclinones; C100408:saquayamycin F; C046893:saquayamycin; C064911:p21(ras) farnesyl-protein transferase