Effects of Photofrin on in vivo skin reflectivity.
Skin reflection spectra were measured before and 24 h after administration of Photofrin to nevoid basal-cell carcinoma syndrome patients. The presence of the drug reduced the reflectivity of uninvolved skin and increased the reflectivity of erythematous basal cell cancers. Data analysis with diffusion approximation and Monte Carlo simulation were employed to estimate the optical constant changes and localized drug concentration.
Jones
L R
LR
Wenske Laser Center, Ravenswood Hospital Medical Center, Chicago, IL 60640, USA.
Grossweiner
L I
LI
D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000503:physiopathology*; D003879:Dermatologic Agents / Q000494:pharmacology*; D017323:Dihematoporphyrin Ether / Q000494:pharmacology*; D006801:Humans; D009010:Monte Carlo Method; D055095:Optics and Photonics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology; D012878:Skin Neoplasms / Q000503:physiopathology*
D003879:Dermatologic Agents; D017323:Dihematoporphyrin Ether