title: Human skin contains luteinizing hormone/chorionic gonadotropin receptors.
abstract: Normal human skin contains a major 4.5 kb and several minor mRNA transcripts and a 66 kDa protein of luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptors which are capable of binding exogenous 125I-hCG. The distribution of receptor transcripts and receptor protein are the highest in epidermis followed by hair follicles, sebaceous and sweat glands. LH/hCG receptors are co-localized with androgen receptors in all the skin appendages. These data are the first demonstration of skin containing LH/hCG receptors and would suggest that LH and hCG may regulate skin functions.
authors.affiliation: Department of Obstetrics and Gynecology, University of Louisville Medical Center, KY 40292, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Pabon
authors.forename: J S
authors.initials: JS
authors.lastname: Bird
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Z H
authors.initials: ZH
authors.lastname: Huang
authors.forename: Z M
authors.initials: ZM
authors.lastname: Lei
authors.forename: J S
authors.initials: JS
authors.lastname: Sanfilippo
authors.forename: M A
authors.initials: MA
authors.lastname: Yussman
authors.forename: C V
authors.initials: CV
authors.lastname: Rao
mesh_terms: D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D007457:Iodine Radioisotopes; D012333:RNA, Messenger / Q000032:analysis; D011944:Receptors, Androgen / Q000032:analysis; D011974:Receptors, LH / Q000032:analysis* / Q000235:genetics; D012867:Skin / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D006063:Chorionic Gonadotropin; D007457:Iodine Radioisotopes; D012333:RNA, Messenger; D011944:Receptors, Androgen; D011974:Receptors, LH