[The effect of sodium diethyldithiocarbamate on the development of organ anlagen in the mouse].
The effect of noradrenaline-depressing natrium diethyldithiocarbamate (DDK) on embryonic tissue was studied in histological preparations. Degenerative changes in cells were found in tissues, exposed to the effect on 10th day of the development. Masses of detrite appear to remove into the cavities of the organs and into the amniotic cavity of the saccus vitellinus which is the characteristic peculiarity of the degenerative changes. After effect on 9-day-year-old embryos degenerative changes were expressed in a different extent-from light in some embryos up to the massive ones in the others. Degenerative changes in giant trophoblast cells, nervous tube, eye rudiment etc were observed in the survived embryos, Prevailing location of the processes was not demonstrated. DDK manifests strong cytotoxic effect. This phenomenon is probably connected with the copper-containing enzymes depression, including those participating in noradrenaline synthesis.
Puchkov
V F
VF
Khozhaĭ
L I
LI
D000818:Animals; D002614:Chelating Agents / Q000633:toxicity*; D004050:Ditiocarb / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005123:Eye / Q000187:drug effects / Q000196:embryology; D005865:Gestational Age; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009420:Nervous System / Q000187:drug effects / Q000196:embryology; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D014327:Trophoblasts / Q000187:drug effects
D002614:Chelating Agents; D004050:Ditiocarb; D009638:Norepinephrine
Vliianie diétilditiokarbamata natriia na razvitie zachatkov organov myshi.