title: (S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
authors.affiliation: Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: TenBrink
authors.forename: C L
authors.initials: CL
authors.lastname: Bergh
authors.forename: J N
authors.initials: JN
authors.lastname: Duncan
authors.forename: D W
authors.initials: DW
authors.lastname: Harris
authors.forename: R M
authors.initials: RM
authors.lastname: Huff
authors.forename: R A
authors.initials: RA
authors.lastname: Lahti
authors.forename: C F
authors.initials: CF
authors.lastname: Lawson
authors.forename: B S
authors.initials: BS
authors.lastname: Lutzke
authors.forename: I J
authors.initials: IJ
authors.lastname: Martin
authors.forename: S A
authors.initials: SA
authors.lastname: Rees
authors.forename: S K
authors.initials: SK
authors.lastname: Schlachter
authors.forename: J C
authors.initials: JC
authors.lastname: Sih
authors.forename: M W
authors.initials: MW
authors.lastname: Smith
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001682:Biological Availability; D016466:CHO Cells; D006224:Cricetinae; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines / Q000037:antagonists & inhibitors; D006801:Humans; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D019257:Quinpirole; D011941:Receptors, Adrenergic / Q000378:metabolism; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000096926:Benzenesulfonamides
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines; D010879:Piperazines; D019257:Quinpirole; D011941:Receptors, Adrenergic; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin; D013449:Sulfonamides; C493599:DRD4 protein, human; C100448:sonepiprazole; D000096926:Benzenesulfonamides