title: The prognostic significance of previous benign breast disease for women with carcinoma of the breast.
abstract: BACKGROUND
  Risk factors for carcinoma of the breast may also have prognostic influence. Because benign breast disease is a risk factor for carcinoma of the breast, we compared the outcomes of patients with carcinoma of the breast with a history of benign breast disease to patients with carcinoma of the breast without a history of benign breast disease.
  
  
  METHODS
  Patients with benign breast disease and subsequent carcinoma of the breast were matched by age and ethnicity to patients with carcinoma of the breast with no prior history of benign breast disease. Risk factors, pathologic findings, and disease-free survival rates were compared.
  
  
  RESULTS
  Patients with previous benign breast disease had a significantly greater family history of carcinoma of the breast (35 percent compared with 22 percent, p = 0.015) and used postmenopausal hormones significantly more frequently (16 percent compared with 5 percent; p < 0.001) than women without benign breast disease. In patients with benign breast disease, their subsequent carcinomas were smaller (T1, 53 percent compared with 43 percent), with significantly fewer nodes involved (1.8 compared with 2.7, p = 0.031), and were significantly more likely to contain an infiltrating lobular component (9 percent compared with 3 percent, p = 0.023). Significantly fewer patients with previous benign breast disease had metastatic disease (18 percent compared with 31 percent; p = 0.001). The ten-year cumulative disease-free survival rate for patients with benign breast disease was 68 percent compared with 59 percent for women without a history of benign breast disease.
  
  
  CONCLUSIONS
  This study indicates that women with benign breast disease who have carcinoma of the breast develop may have a better outcome than women without a history of benign breast disease.
authors.affiliation: Department of Surgery, Mount Sinai Medical Center, New York, NY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ahmed
authors.forename: P I
authors.initials: PI
authors.lastname: Tartter
authors.forename: S
authors.initials: S
authors.lastname: Jothy
authors.forename: S T
authors.initials: ST
authors.lastname: Brower
authors.forename: J
authors.initials: J
authors.lastname: Bratton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000150:complications*; D001943:Breast Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D015983:Selection Bias; D015996:Survival Rate