Deletion in the 190 kDa antigen gene repeat region of Rickettsia rickettsii.
The 190 kDa outer membrane protein of Rickettsia rickettsii is a major immunodominant protective antigen which contains 13 tandem nearly identical repeating sequences. We have identified a deletion in the 190 kDa antigen gene of R. rickettsii strain Smith maintained in the laboratory. The deletion occurred within the repeat region of this gene and the mutated repeat region corresponded to one repeating unit in size.
Matsumoto
M
M
First Department of Internal Medicine, School of Medicine, Ehime University, Japan.
Tange
Y
Y
Okada
T
T
Inoue
Y
Y
Horiuchi
T
T
Kobayashi
Y
Y
Fujita
S
S
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D016056:Immunodominant Epitopes / Q000235:genetics; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D012284:Rickettsia rickettsii / Q000235:genetics* / Q000276:immunology; D017384:Sequence Deletion
C100534:190 kDa antigen, Rickettsia; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D016056:Immunodominant Epitopes