title: [Analysis of penbutolol and its metabolites in human body fluid by gas chromatography--mass spectrometry].
abstract: A method for the detection and identification of penbutolol and its metabolites in human body fluid by using gas chromatography-mass spectrometry was established. The urine was extracted with diethyl ether-isopropanol and the plasma was extracted with Sep-Pak column. After TMS derivatization the sample was analyzed with GC-MSD. Six metabolites of penbutolol were found in urine sample. The recovery was 90.83% for urine and 85.88% for plasma. The detection limit of penbutolol was 5 pg.
authors.affiliation: China Doping Control Center, National Research Institute of Sports Medicine, Beijing.
authors.forename: L
authors.initials: L
authors.lastname: Shen
authors.forename: Y X
authors.initials: YX
authors.lastname: Xu
authors.forename: C J
authors.initials: CJ
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: K R
authors.initials: KR
authors.lastname: Cui
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000378:metabolism* / Q000652:urine; D000328:Adult; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D010394:Penbutolol / Q000378:metabolism* / Q000652:urine
chemical_list: D000319:Adrenergic beta-Antagonists; D010394:Penbutolol