title: Effects of dose reduction on digital chest imaging using a selenium detector: a study of detecting simulated diffuse interstitial pulmonary disease.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of dose reduction on the diagnostic performance of a new digital chest imaging system in which amorphous selenium is used as the X-ray detector. Diagnostic performance was assessed for the detection of simulated diffuse interstitial pulmonary disease (DIPD).
  
  
  METHODS
  DIPD was simulated by superimposing plastic sheets that contained small radiopaque objects (birdseed) on an anthropomorphic chest phantom. We varied the number of sheets from zero to four to simulate the degree of abnormality. We made 80 images with a standard X-ray dose, 80 images with 55% of the standard dose, and 80 images with 35% of the standard dose. Six observers were asked to indicate the presence of DIPD using a five-level scale of confidence. Two hundred forty chest images were then analyzed using receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  The area under the ROC curve was 87.2 for all readers with standard-dose imaging (95% confidence interval [CI], 83.7-90.7), 91.7 with 55% of the standard dose (95% CI, 88.8-94.6), and 90.0 with the 35% dose (95% CI, 87.1-92.9). The area under the ROC curve for subtle DIPD (one superimposed sheet) was 75.3 for all readers with standard-dose imaging (95% CI, 67.1-83.5), 79.7 with 55% of the standard dose (95% CI, 71.9-87.5), and 70.3 with the 35% dose (95% CI, 61.7-78.9). For each dose, we observed a gradual improvement of the ROC curves with each additional sheet superimposed on the chest phantom (p < .001).
  
  
  CONCLUSIONS
  We found no significant difference in diagnostic performance among images made with standard X-ray dose, those made with a 55% dose, and those made with a 35% dose (95% CI).
authors.affiliation: Department of Diagnostic Radiology, St. Antonius Hospital, Nieuwegein (Utrecht), The Netherlands.
authors.forename: H P
authors.initials: HP
authors.lastname: van Heesewijk
authors.forename: Y
authors.initials: Y
authors.lastname: van der Graaf
authors.forename: J C
authors.initials: JC
authors.lastname: de Valois
authors.forename: M A
authors.initials: MA
authors.lastname: Feldberg
mesh_terms: D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D012372:ROC Curve; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement / Q000295:instrumentation* / Q000379:methods; D013902:Radiography, Thoracic / Q000295:instrumentation* / Q000379:methods; D012643:Selenium
chemical_list: D012643:Selenium