title: [Prevention of second primary cancer with vitamin supplementation in patients treated for head and neck cancers].
abstract: Second primary cancers often occur in head and neck cancer patients successfully treated by radiation therapy. Experimental and epidemiological data suggest that these second primaries might be prevented by antioxidant vitamins, in particular beta-carotene and alpha-tocopherol. A randomized double-blind clinical trial is being conducted in Canada to determine whether vitamin supplementation with beta-carotene (30 mg/d) and alpha-tocopherol (400 IU/d) reduces the incidence of second primaries in head and neck cancer patients treated by radiation therapy.
authors.affiliation: Groupe de recherche en épidémiologie de l'Université Laval, Québec, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Bairati
authors.forename: F
authors.initials: F
authors.lastname: Brochet
authors.forename: J
authors.initials: J
authors.lastname: Roy
authors.forename: M
authors.initials: M
authors.lastname: Gélinas
authors.forename: A
authors.initials: A
authors.lastname: Nabid
authors.forename: B
authors.initials: B
authors.lastname: Têtu
authors.forename: B
authors.initials: B
authors.lastname: Mâsse
authors.forename: F
authors.initials: F
authors.lastname: Meyer
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000178:diet therapy* / Q000473:pathology; D002338:Carotenoids / Q000008:administration & dosage; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000178:diet therapy* / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000517:prevention & control*; D012307:Risk Factors; D014675:Vegetables; D014801:Vitamin A / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D014815:Vitamins / Q000627:therapeutic use*; D019207:beta Carotene
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D014815:Vitamins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; D000111:Acetylcysteine
vernacular_title: Prévention des seconds cancers primaires par supplémentation vitaminique chez les patients traités pour un cancer ORL.