Treatment of persistent glaucoma secondary to periocular corticosteroids.
OBJECTIVE
To describe two patients with uveitis who developed increased intraocular pressure that was unresponsive to maximum medical therapy eight and 13 months after periocular injection of triamcinolone acetonide.


METHODS
Excised periocular tissue was analyzed for corticosteroid activity by gas chromatography and mass spectrometry.


RESULTS
Excision of the periocular tissue, which contained visible triamcinolone acetonide, resulted in a normal intraocular pressure within 14 days in both patients. Analysis of the excised tissue disclosed residual corticosteroid in one of the two patients.


CONCLUSIONS
Removal of periocular tissue containing injected corticosteroids may facilitate the management of patients developing increased intraocular pressure unresponsive to maximum medical therapy.
Akduman
L
L
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110-1096, USA.
Kolker
A E
AE
Black
D L
DL
Del Priore
L V
LV
Kaplan
H J
HJ
D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002648:Child; D000071938:Fasciotomy; D005901:Glaucoma / Q000139:chemically induced / Q000628:therapy*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced / Q000628:therapy; D009915:Orbit / Q000187:drug effects / Q000601:surgery; D014222:Triamcinolone Acetonide / Q000009:adverse effects* / Q000627:therapeutic use; D014605:Uveitis / Q000150:complications / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D014222:Triamcinolone Acetonide