title: Endoscopic ultrasonography and real-time guided fine-needle aspiration biopsy of solid lesions of the mediastinum suspected of malignancy.
abstract: OBJECTIVE
  The study details our preliminary experience with endoscopic ultrasonography (EUS) guided fine-needle aspiration biopsy (FNAB) of mediastinal masses suspected of malignancy.
  
  
  METHODS
  Prospective uncontrolled study.
  
  
  METHODS
  Nine patients had lesions suspected of malignancy ranging from 1 to 9 cm in diameter in various locations of the mediastinum.
  
  
  METHODS
  The EUS examination was performed with a gastroscope (Hitachi/Pentax FG-32 UA) equipped with an adjustable 5- or 7.5-MHz curved array ultrasonic transducer. The scanning plane is in the long axis of the endoscope allowing endosonographically guided biopsy to be performed. A 21-gauge (0.8 mm), full-length steel needle housed in a biopsy handle (type: Hancke/Vilmann; GIP-Medizin Technik; Grassau, Germany) was used for the biopsies.
  
  
  RESULTS
  Nine patients had biopsy specimens taken from 13 lesions. The total number of needle passes was 18 (range, 1 to 3; median, 1.4). The cytologic diagnosis was conclusive for cancer in ten lesions and consistent with a benign lesion in three lesions. All ten malignant diagnoses and two benign diagnoses were confirmed either by operation or follow-up. In the last patient with lung cancer, a final diagnosis of the EUS-guided biopsy of an enlarged lymph node could not be obtained. No false-positive or negative biopsy diagnoses were recorded. The biopsy procedure was well tolerated by all patients, and there were no complications.
  
  
  CONCLUSIONS
  EUS-guided aspiration biopsy is a significant advance in the differentiation between malignant and benign lesions of the mediastinum carrying a high diagnostic potential.
authors.affiliation: Department of Radiology, Gentofte University Hospital, Copenhagen, Denmark.
authors.forename: B H
authors.initials: BH
authors.lastname: Pedersen
authors.forename: P
authors.initials: P
authors.lastname: Vilmann
authors.forename: K
authors.initials: K
authors.lastname: Folke
authors.forename: G K
authors.initials: GK
authors.lastname: Jacobsen
authors.forename: M
authors.initials: M
authors.lastname: Krasnik
authors.forename: N
authors.initials: N
authors.lastname: Milman
authors.forename: S
authors.initials: S
authors.lastname: Hancke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000295:instrumentation / Q000379:methods; D019723:Endoscopes; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies; D018084:Ultrasonography, Interventional / Q000295:instrumentation