title: Comparison of antimicrobial properties of monoterpenes and their carbonylated products.
abstract: Some monoterpenes and their carbonylated products were evaluated for their antibacterial and antifungal properties. The carbonylation of tested monoterpenes was shown to increase the bacteriostatic and fungistatic activities specifically by the contact method. Concerning the killing effects, only (1R,2S,5R)-isopulegol, its carbonylated products, and (R)-carvone showed significant bactericidal activities, particularly against Enterococcus faecium and Escherichia coli above a concentration of 10 microliters/ml. A fungicidal efficiency of (1R,2S,5R)-isopulegol and (R)-carvone against Aspergillus niger was also noted. It seems that the presence of an oxygenated function in the framework increases the antimicrobial properties. However, monoterpenes were more active using a micro-atmosphere method.
authors.affiliation: Laboratoire de Chimie des Procédés, Ecole Nationale Supérieure de Chimie de Toulouse, France.
authors.forename: R
authors.initials: R
authors.lastname: Naigre
authors.forename: P
authors.initials: P
authors.lastname: Kalck
authors.forename: C
authors.initials: C
authors.lastname: Roques
authors.forename: I
authors.initials: I
authors.lastname: Roux
authors.forename: G
authors.initials: G
authors.lastname: Michel
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D013729:Terpenes