Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice.
2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), which is a heterocyclic amine found in food and the potent mutagen in S. typhimurium TA98, was examined for its genotoxic potential using lacI transgenic mice (Big Blue, C57BL/6N lineage). Female mice, at 7 weeks of age, were given a diet containing 0.03% MeIQ for 1, 4 and 12 weeks, and mutant frequencies (MF) were analyzed in the bone marrow, liver, forestomach, colon and heart. The MF increased in a feeding period-dependent manner. Relative to untreated mice, the MF after a 12-week-feeding of MeIQ was 38 times higher in the colon, 5.8 times higher in the bone marrow, 4.6 times higher in the liver, and 2.6 times higher in the forestomach. No increase in MF was detected in the heart, where no tumors develop.
Suzuki
T
T
Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan. suzuki@nihs.nihs.go.jp
Hayashi
M
M
Ochiai
M
M
Wakabayashi
K
K
Ushijima
T
T
Sugimura
T
T
Nagao
M
M
Sofuni
T
T
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000473:pathology; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D011804:Quinolines / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology
D009153:Mutagens; D011804:Quinolines; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline