The JAK-STAT pathway: summary of initial studies and recent advances.
Polypeptides redirect cells by causing immediate changes in gene transcription. A direct connection between polypeptide receptors on the cell surface and genes in the nucleus has been provided by the recognition of the JAK-STAT pathway. Results leading to our present understanding of this pathway are reviewed.
Darnell
J E
JE
Rockefeller University, New York, New York 10021, USA.
D000818:Animals; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D015534:Trans-Activators; D007372:Interferons; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases