[Angiogenesis of human breast cancers: neovascularization in xenotransplants and oxygenation in situ in patients].
OBJECTIVE
Recent reports have shown that vascularization of breast cancers is an independent prognostic parameter. Tumor growth and neovascularization were investigated in xenotransplants of breast cancers and tissue oxygenation was measured in patients with breast tumors.


METHODS
Tumor cells of the breast cancer MX-1 were implanted intradermally in 40 nude mice. Tumor growth and neovascularization were quantified microscopically. Tissue oxygenation was determined in 66 patients with breast tumors using the pO2-histography technique.


CONCLUSIONS
The angiogenesis begins prior to tumor growth, is insufficient and leads to chaotic blood flow. This results in a heterogeneity of tissue oxygenation in breast cancers. Oxygenation at the tumor periphery appears to be of prognostic importance for clinical outcome of breast cancer.
Runkel
S
S
Frauenklinik Mannheim, Klinische Fakultät, Universität Heidelberg.
Wayss
K
K
Melchert
F
F
D000818:Animals; D001943:Breast Neoplasms / Q000098:blood supply* / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010101:Oxygen Consumption / Q000502:physiology*; D011379:Prognosis
Angiogenese von menschlichen Mammakarzinomen: Neo-Vaskularisation in Xenotransplantaten und Oxygenierung in situ bei Patientinnen.