title: Demographic characteristics of patients undergoing aortic valve replacement for stenosis: relation to valve morphology.
abstract: OBJECTIVE
  To determine the relative importance of the different causes of isolated aortic valve stenosis in a surgical series, and to relate these to patient characteristics including the rate of insertion of bypass grafts for coronary artery disease.
  
  
  METHODS
  Survey of the clinical and pathological data on patients undergoing aortic valve replacement for isolated stenosis.
  
  
  METHODS
  Tertiary care cardiothoracic surgical unit.
  
  
  METHODS
  465 adult patients undergoing aortic valve replacement representing a consecutive series in one surgical unit. Retrospective review of patients records and classification of cause of aortic stenosis based on pathological examination of excised valve cusps.
  
  
  RESULTS
  63.7% patients had calcific bicuspid valves, 26.9% tricuspid calcific valves, and 5.4% rheumatic, 2.6% mixed pathology and 1.5% unicommissural valves. The ratio of males to females for bicuspid valves was 1.85:1 and for tricuspid calcific valves 0.76:1. The mean age of patients with bicuspid valves was 64.9 years compared with 73.4 years for those with tricuspid valves. Some 22.3% of patients with bicuspid valves and 44.8% of those with tricuspid valves had sufficient coronary artery disease to necessitate insertion of coronary bypass grafts. The differential rate of insertion of coronary bypass grafts was independent of age.
  
  
  CONCLUSIONS
  Bicuspid calcified aortic valves are the predominant cause of isolated aortic valve stenosis followed by tricuspid calcified aortic valves. The sex and age distribution of bicuspid and tricuspid calcific aortic valve stenosis is different. The higher rate of insertion of vascular grafts in tricuspid calcific aortic valves may indicate that risk factors for atherosclerosis enhance cusp calcification in these patients.
authors.affiliation: BHF Cardiovascular Pathology Unit, St George's Hospital Medical School, London.
authors.forename: M J
authors.initials: MJ
authors.lastname: Davies
authors.forename: T
authors.initials: T
authors.lastname: Treasure
authors.forename: D J
authors.initials: DJ
authors.lastname: Parker
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002114:Calcinosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012214:Rheumatic Heart Disease / Q000150:complications / Q000473:pathology / Q000601:surgery; D012737:Sex Factors