title: Carcinosarcoma of the liver with mesenchymal differentiation: a case report.
abstract: Carcinosarcoma of the liver with mesenchymal differentiation are very rare in adult patients. A case is reported with an exhaustive pathologic examination and review of the literature. A 61-year old man presented with general fatigue and dull abdominal pain. Two liver masses were diagnosed and resected by a right hepatectomy. Specimen pathology revealed that the tumor and lymph node consisted of two cancerous components. One carcinomatous component corresponding to a hepatocellular carcinoma and a sarcomatous component characterized by a diffuse proliferation of spindle shaped cells with chondrosarcomatous and osteosarcomatous changes. Patient died 9 months later of a diffusion of the tumor. For the first time, to our knowledge, a mesenchymal differentiation is demonstrated in liver carcinosarcoma.
authors.affiliation: Department of Pathology, Hopital Antoine Beclere, University of Paris XI, Clamart France.
authors.forename: M B
authors.initials: MB
authors.lastname: Leger-Ravet
authors.forename: G
authors.initials: G
authors.lastname: Borgonovo
authors.forename: A
authors.initials: A
authors.lastname: Amato
authors.forename: G
authors.initials: G
authors.lastname: Lemaigre
authors.forename: D
authors.initials: D
authors.lastname: Franco
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D002813:Chondrosarcoma / Q000473:pathology; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008648:Mesoderm / Q000473:pathology; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D007633:Keratins