Laryngeal lymphoma derived from mucosa-associated lymphoid tissue.
Extranodal lymphomas account for as many as 40% of non-Hodgkin's lymphomas, and most arise in the gastrointestinal tract, but other mucosal organs may be involved, especially the upper aerodigestive tract. Low-grade B-cell lymphomas arising in the gastrointestinal tract and other mucosae have been found to recapitulate the structure and cytologic features of mucosa-associated lymphoid tissue (MALT). Histologically low-grade MALT lymphomas are characterized by centrocyte-like B-cells with a phenotype similar to that of so-called marginal zone B-cells. Tumors evolving from MALT are generally rare among lymphomas of the upper aerodigestive tract, but a few cases of laryngeal lymphomas derived from MALT have been reported. Primary MALT lymphoma of the larynx should always be considered in tumors with histopathologic features of low-grade B-cell lymphoma, or so-called pseudolymphoma.
Horny
H P
HP
Institut für Pathologie, Universität Tubingen, Germany.
Ferlito
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Carbone
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D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D007830:Larynx / Q000473:pathology* / Q000648:ultrastructure; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000648:ultrastructure; D012189:Retrospective Studies