Synthesis and antibacterial activity of C-4 thio- and dithiocarbamate monobactam derivatives.
New series of monobactam antibiotics, bearing thio-and dithiocarbamate derivatives as C-4 side chain, were synthesized. Some compounds were found to have good antibacterial activity against Gram-negative bacteria.
Cascio
G
G
Lusofarmaco, Laboratorio di Ricerca Chimica, Milano, Italy.
Lorenzi
L
L
Caglio
D
D
Manghisi
E
E
Arcamone
F
F
Guanti
G
G
Satta
G
G
Morandotti
G
G
Sperning
R
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000138:chemical synthesis* / Q000494:pharmacology; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008997:Monobactams; D013859:Thiocarbamates