title: Can evolutionary principles help resolve the acquired immune deficiency syndrome crisis?
abstract: The population of retroviruses inside each infected host can quickly adapt its genes in response to survival threats. For this reason, therapeutics attempting to eliminate or inhibit the human immunodeficiency virus have been unsuccessful. However, it may be possible to apply evolutionary principles to the problem of human immunodeficiency virus infection/acquired immune deficiency syndrome. The rapid evolution capabilities of this pathogen might assist researchers in evolving human immunodeficiency virus toward the goal of virus-host coexistence. In this relationship, infecting viruses do not harm their host. Two different examples illustrate the theoretical application of evolutionary principles to this problem. First, by viewing the virus as a new gene of the immune system, it is possible to evolve this gene toward the goal of improving immune function. Second, the retroviral population of each host is maladapted for long-term survival. Retroviral genes could be evolved with respect to continued existence in the host.
authors.affiliation: evolvhiv@fortnet. org
authors.forename: P D
authors.initials: PD
authors.lastname: Powell
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000276:immunology / Q000821:virology*; D005075:Biological Evolution; D017753:Ecosystem; D005814:Genes, Viral; D006678:HIV / Q000235:genetics / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008954:Models, Biological