title: [Epidemiological behavior of perforated peptic ulcer before and after the introduction of the antisecretory drug therapy. Our experience].
abstract: The diagnostic iter and treatment of peptic ulcer have evolved considerably over the past 20 years. The capillary spread of endoscopy has permitted secure and precise diagnoses to be made, in terms of both the site and size of the anatomic lesion, on the one hand, and on the other, the introduction of antisecretory drugs has led to the resolution of the majority of ulcers, so much so that the ulcer is no longer managed using strictly surgical methods but is now treated medically and only emergency cases, such as perforations, undergo surgery. Complications, such as digestive hemorrhage, penetration and stenosis, may lead to the need for surgery. In particular, perforation seems to be the only complication which has not been significantly influenced by the introduction of antisecretory therapy, the point that its status as a "complication" has been questioned leading to the suspicion of its nosological autonomy. The authors review the series of ulcer patients admitted to hospital during the period 1968 to 1991, paying special attention to the correlation with the use of antisecretory drugs which were introduced during the period 1978-1981, the trend of ulcer complications over the entire period, the duration of symptoms and the epidemiology of peptic and perforated ulcers.
authors.affiliation: II Divisione di Chirurgia Generale, Ospedali Riuniti, Bergamo.
authors.forename: R
authors.initials: R
authors.lastname: Sacco
authors.forename: A
authors.initials: A
authors.lastname: Giovanelli
authors.forename: L
authors.initials: L
authors.lastname: Giuliano
authors.forename: D
authors.initials: D
authors.lastname: Piazzalunga
authors.forename: E M
authors.initials: EM
authors.lastname: Poletti
authors.forename: F
authors.initials: F
authors.lastname: Arrigoni
authors.forename: G B
authors.initials: GB
authors.lastname: Cassinelli
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004381:Duodenal Ulcer / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D010439:Peptic Ulcer Perforation / Q000453:epidemiology* / Q000601:surgery; D012737:Sex Factors; D013276:Stomach Ulcer / Q000150:complications* / Q000188:drug therapy
chemical_list: D006635:Histamine H2 Antagonists
vernacular_title: Il comportamento epidemiologico dell'ulcera peptica perforata prima e dopo l'introduzione della terapia medica antisecretiva.