Adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone.
A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone is reported. A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adrenal tumor. The plasma level of aldosterone was normal, and the levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were extremely high. After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were normalized. The tumor was benign adenoma and the production of steroid hormones was under control of adrenocorticotropic hormone. The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue.
Toyoda
Y
Y
Department of Internal Medicine, Arida Municipal Hospital, Wakayama.
Mizukoshi
M
M
Umemoto
M
M
Kuchii
M
M
Ueyama
K
K
Tomimoto
S
S
Baba
A
A
Shima
H
H
Nishio
I
I
Masuyama
Y
Y
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood*; D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000450:Aldosterone / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D008875:Middle Aged; D012083:Renin / Q000097:blood; D014057:Tomography, X-Ray Computed
D015070:18-Hydroxydesoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone