[Immunohistochemical analysis of nm23 gene product/nucleoside-diphosphate kinase expression in human lung carcinoma].
It was proposed that nm23 gene may function as a suppressor gene for tumor metastasis. Using an antibody to NDPK, levels of NDPK/nm23 expression in lung carcinomas were examined immunohistochemically, 45 of 58 squamous carcinomas and 26 of 36 adenocarcinomas showed strong immunoreactivity for NDPK/nm23 in most of cancer cells within tumor tissues. On some normal bronchial epithelium and serous glands, there also show weak expression. No relationship was found between NDPK/nm23 expression and clinicopathological parameters including tumor grade, size, nodal involvement and stage but the increases in NDPK/nm23 expression were stronger in advanced stages of squamous cell carcinomas. In conclusion, our results indicate that the increased NDPK/nm23 expression in the analysed carcinomas is not consistent with the proposed metastasis-suppressor function, but the nm23 gene may be implicated in the mechanism of carcinogenic process and tumor progression.
Jiang
Y
Y
He
A
A
Xia
S
S
D000230:Adenocarcinoma / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D003593:Cytoplasm / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics*; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins