title: Out-of-hospital sudden death referring to an emergency department.
abstract: Over an 11-year period, autopsies were performed on 957 of 1038 nontraumatic deaths in the Emergency Department of the Central Hospital in Ferrara, Italy. Of these 957 cases, 732 (76.5%) met criteria for sudden death. In 100 (14%) of these cases, the death could be attributed to pulmonary embolism (55 cases), stroke (17), or rupture of aortic aneurysm (28). Acute myocardial infarction accounted for 403 (55%) of all sudden deaths. Severe coronary artery disease was found in 340 (84%) of these 403 deaths, with plaque fissuring or thrombi in 189 or 151 cases, respectively. Among the 229 sudden deaths for whom no immediate cause could be determined (31% of the total population), all had evidence of heart disease: 147 individuals had severe coronary artery disease, with plaque fissuring or thrombi found in 72 or 43, respectively. The remaining cases with no immediate cause of death had evidence of a cardiomyopathy (61) or valvular disease (21). We conclude that acute myocardial infarction accounts for the majority of cases of nontraumatic sudden death in our Emergency Department. Altogether, 84% of these patients had severe coronary artery disease. In approximately one-third of cases for whom no immediate cause of sudden death could be determined, all had evidence of heart disease, and about two-thirds had severe coronary artery disease.
authors.affiliation: First Institute of Internal Medicine, University of Ferrara, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Manfredini
authors.forename: F
authors.initials: F
authors.lastname: Portaluppi
authors.forename: E
authors.initials: E
authors.lastname: Grandi
authors.forename: C
authors.initials: C
authors.lastname: Fersini
authors.forename: M
authors.initials: M
authors.lastname: Gallerani
mesh_terms: D002423:Cause of Death; D003327:Coronary Disease / Q000401:mortality; D003645:Death, Sudden / Q000453:epidemiology / Q000209:etiology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology; D004632:Emergency Medical Services / Q000706:statistics & numerical data; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D011446:Prospective Studies