In vitro selective modulation of cellular glutathione by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model.
We report the in vitro selective inhibitory activity of a humanized whey protein concentrate IMMUNOCAL on growth of mammary carcinoma cells and Jurkat T cells in comparison to normal peripheral blood mononuclear cells. We relate this inhibitory activity to a selective depletion of intracellular glutathione synthesis. The use of humanized whey protein concentrate as a food supplementation may have direct implication in clinical trial with adjuvant chemotherapy.
Baruchel
S
S
Department of Pediatrics and Oncology, McGill University, Montreal, Quebec, Canada.
Viau
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D005260:Female; D005978:Glutathione / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D008894:Milk Proteins / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000067816:Whey Proteins
D008894:Milk Proteins; D000067816:Whey Proteins; D005978:Glutathione