title: [Detection of prostatic cancer in symptomatic patients with serum levels of prostate-specific antigen between 4 and 10 ng/ml].
abstract: OBJECTIVE
  Determine the incidence of prostate cancer in patients consulting for common miction disorders and serum prostatic specific antigen (PSA) between 4 and 10 ng/ml.
  
  
  METHODS
  A total of 153 patients consulted for miction disorders. In 107 of them, the digital examination was abnormal and PSA was between 4 and 10 ng/ml. Transrectal sonography and prostatic biopsies were performed in these 107 patients. We determined the number of cancers detected and assessed the contribution of PSA density (PSAD) to diagnosis. In patients undergoing radical prostatectomy, invasion of the capsule (C+) and positive exeresis section (M+) were recorded.
  
  
  RESULTS
  Cancer of the prostate was diagnosed in 29.4% of the patients on the basis of at least 1 of the 6 biopsies. This rate was 47.8% in patients with an abnormal and 21.5% with a normal digital examination. Radical prostatectomy was performed in 32 patients: 50% of them were C+ and 33% M+.
  
  
  CONCLUSIONS
  Biopsy of the prostate is indicated in patients with an abnormal prostate at digital examination when PSA is between 4 and 10 ng/ml. When the prostate appears to be normal, PSAD may be helpful in determining when to perform a biopsy. Intermediary serum PSA levels do not guarantee favorable pathological characteristics.
authors.affiliation: Service d'Urologie, CHU Bichat, Paris.
authors.forename: V
authors.initials: V
authors.lastname: Ravery
authors.forename: H P
authors.initials: HP
authors.lastname: Schmid
authors.forename: T
authors.initials: T
authors.lastname: Billebaud
authors.forename: M
authors.initials: M
authors.lastname: Toublanc
authors.forename: L
authors.initials: L
authors.lastname: Boccon-Gibod
authors.forename: J F
authors.initials: JF
authors.lastname: Hermieu
authors.forename: V
authors.initials: V
authors.lastname: Delmas
authors.forename: L
authors.initials: L
authors.lastname: Boccon-Gibod
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen
vernacular_title: Détection du cancer prostatique chez les patients symptomatiques ayant des taux d'antigène prostatique spécifique sérique entre 4 et 10 ng/ml.