[Skin carcinogenesis induced be neonatal administration of 5-bromo-2'-deoxyuridine and subsequent treatment with 12-O-tetradecanoylphorbol-13-acetate in mice].
Male and female SHR mice were injected, subcutaneously, 1 mg of 5-bromo-2'-deoxyuridine (BrdUrd) or 0.05 ml of distilled water on days 1, 3 and 7 after birth and painted with 6.15 mkg of TPA dissolved in 0.1 ml of acetone, or acetone alone, twice a week, for 24 weeks, starting at the age of 15 weeks. The animals were followed up for 20 weeks after stopping TPA painting. Skin tumors emerged in TPA-treated animals only. TPA painting was followed by skin papilloma development in 20.9% of males and 36.6% females injected distilled water neonatally, tumors regressing in 88.4% of males and 85.4% of females by the end of the experiment. With combined treatments with BrdUrd and TPA, skin papilloma incidence was 56.5% in males and 52.6% in females, tumors persisting in 52.2% and 39.6%, respectively, until the end of the experiment.
Anisimov
V N
VN
Sheiko
E V
EV
D000818:Animals; D001973:Bromodeoxyuridine / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000139:chemically induced*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D002273:Carcinogens; D001973:Bromodeoxyuridine; D013755:Tetradecanoylphorbol Acetate
Kantserogenez kozhi, indutsirovannyĭ neonatal'nym vvedeniem 5-bromo-2'-dezoksiuridina i posleduiushchim vozdeĭstviem 12-O-tetradekanoilforbol-13-atsetata u mysheĭ.