title: [Muscle relaxation with atracurium in myasthenia gravis].
abstract: This report concerns a narcosis in a 42-year-old female patient suffering from myasthenia gravis in a state of clinical remission after thymectomia. Six months after thymectomia relaxometric control (Datex AMG) was performed while the patient underwent major colorectal surgery. We found a persisting sensitivity to relaxants during isoflurane anaesthesia supplemented with fentanyl. During 270 minutes of anaesthesia we needed only 25 mg atracurium (0.4 mg/kg bodyweight) only 57% of a theoretical normal dose. This is the result of a continuing muscular weakness in asymptomatic patients suffering from clinically reliable myasthenia gravis. Therefore, a reduced demand for muscle relaxants can be expected in these patients.
authors.affiliation: Abteilung I, Medizinischen Hochschule Hannover.
authors.forename: R
authors.initials: R
authors.lastname: Walz
authors.forename: N
authors.initials: N
authors.lastname: Lübbe
authors.forename: K
authors.initials: K
authors.lastname: Walz
authors.forename: K H
authors.initials: KH
authors.lastname: Mahr
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001279:Atracurium / Q000008:administration & dosage*; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016343:Monitoring, Intraoperative; D009157:Myasthenia Gravis / Q000601:surgery*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000601:surgery*; D012086:Reoperation; D013934:Thymectomy
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium
vernacular_title: Muskelrelaxation mit Atracurium bei Myasthenia gravis.