title: The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis.
abstract: Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; 17 and 4 of them, respectively, have been isolated and characterized. Up-regulated genes whose function can be predicted on the basis of their sequence include four transcription factors (including one of the thyroid hormone receptors), an extracellular matrix component (fibronectin) and membrane receptor (integrin), four proteinases, a deiodinase that degrades thyroid hormone, and a protein that binds the hypothalamic corticotropin-releasing factor, which has been implicated in controlling thyroid hormone synthesis in Xenopus tadpoles. All four down-regulated genes encode extracellular proteins that are expressed in tadpole epidermis. This survey of the program provides insights into the biology of metamorphosis.
authors.affiliation: Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Brown
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: J D
authors.initials: JD
authors.lastname: Furlow
authors.forename: A
authors.initials: A
authors.lastname: Kanamori
authors.forename: R A
authors.initials: RA
authors.lastname: Schwartzman
authors.forename: B F
authors.initials: BF
authors.lastname: Remo
authors.forename: A
authors.initials: A
authors.lastname: Pinder
mesh_terms: D000818:Animals; D001483:Base Sequence; D010450:Endopeptidases / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008675:Metamorphosis, Biological; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis; D012333:RNA, Messenger / Q000235:genetics; D013963:Thyroid Hormones / Q000502:physiology; D014018:Tissue Distribution; D014157:Transcription Factors / Q000502:physiology; D014982:Xenopus laevis / Q000254:growth & development*
chemical_list: D012333:RNA, Messenger; D013963:Thyroid Hormones; D014157:Transcription Factors; D010450:Endopeptidases