title: Norplant subdermal contraceptive system: experience in Taiwan.
abstract: From November 1988 to December 1994, a total of 567 female volunteers were enrolled in Norplant implant studies at the National Taiwan University Hospital. After a median follow-up of 29 months, only 3 of the 529 available cases became pregnant (a cumulative rate of 1.2 pregnancies per 100 users over 5 years). Chromosome analysis of 2 of the 3 abortuses revealed 46,XX/46,XX,inv(3) and 46,XX. Menstrual problems were the most common adverse effects and were also the main reason for discontinuation (65%, 108/166). The continuation rate was 90%, 78%, 70%, 61%, and 42% at the end of 1, 2, 3, 4, and 5 years after insertion, respectively. In the 21 patients who wished to become pregnant, fertility recurred soon after removal of the Norplant implants. The data suggested that the Norplant implants system is a highly effective, safe, and long-acting method of reversible contraception. It would be worthwhile to introduce this contraceptive system to Taiwan's family planning program.
authors.affiliation: Department of Medical Genetics, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: L H
authors.initials: LH
authors.lastname: Tseng
authors.forename: T Y
authors.initials: TY
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Yang
authors.forename: T M
authors.initials: TM
authors.lastname: Ko
authors.forename: S M
authors.initials: SM
authors.lastname: Chuang
mesh_terms: D000028:Abortion, Induced; D002869:Chromosome Aberrations; D003271:Contraceptive Agents, Female; D004343:Drug Implants; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000009:adverse effects; D008599:Menstruation Disturbances / Q000139:chemically induced; D011247:Pregnancy; D013624:Taiwan; D013997:Time Factors
chemical_list: D003271:Contraceptive Agents, Female; D004343:Drug Implants; D016912:Levonorgestrel