The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice.
We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2-n-pentylquinoline showed activity against P. vinckei petteri. This result seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.
Gantier
J C
JC
Laboratoire de Biologie et Contrôle des Organismes Parasites, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.
Fournet
A
A
Munos
M H
MH
Hocquemiller
R
R
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000627:therapeutic use*; D001838:Bolivia; D002738:Chloroquine / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts; D010946:Plants, Medicinal; D010961:Plasmodium; D011804:Quinolines / Q000302:isolation & purification / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000962:Antimalarials; D010936:Plant Extracts; D011804:Quinolines; D002738:Chloroquine