(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
TenBrink
R E
RE
Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
Bergh
C L
CL
Duncan
J N
JN
Harris
D W
DW
Huff
R M
RM
Lahti
R A
RA
Lawson
C F
CF
Lutzke
B S
BS
Martin
I J
IJ
Rees
S A
SA
Schlachter
S K
SK
Sih
J C
JC
Smith
M W
MW
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001682:Biological Availability; D016466:CHO Cells; D006224:Cricetinae; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines / Q000037:antagonists & inhibitors; D006801:Humans; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D019257:Quinpirole; D011941:Receptors, Adrenergic / Q000378:metabolism; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000096926:Benzenesulfonamides
D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines; D010879:Piperazines; D019257:Quinpirole; D011941:Receptors, Adrenergic; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin; D013449:Sulfonamides; C493599:DRD4 protein, human; C100448:sonepiprazole; D000096926:Benzenesulfonamides