Testicular lactate dehydrogenase and sorbitol dehydrogenase activity after intratesticular injection of dynorphin and morphine in male rats.
Testicular lactate dehydrogenase (LDH) and sorbitol dehydrogenase (SDH) activity were measured at 1 and 4 hr following intratesticular injection of morphine and dynorphin. Twenty five and 50 micrograms doses of morphine sulfate significantly reduced LDH activity at 1 hr after injection. Five and 25 micrograms doses of dynorphin reduced LDH activity both at 1 and 4 hr after treatment. Testicular SDH activity was increased by morphine at 1 hr followed by a decrease at 4 hr. Both doses of dynorphin significantly reduced SDH activity at 1 and 4 hr after treatment. These results indicate paracrine regulatory role for opioids in testicular metabolism.
Sreenivasan
P
P
School of Life Sciences, Pondicherry University, India.
Vijayan
E
E
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004399:Dynorphins / Q000494:pharmacology*; D007064:L-Iditol 2-Dehydrogenase / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D000701:Analgesics, Opioid; D004399:Dynorphins; D009020:Morphine; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase