Preclinical animal studies with radioiododeoxyuridine.
We examined the diagnostic and therapeutic potential of 5-iodo-2'- deoxyuridine (IUdR) radiolabeled with the Auger electron emitters 123I and 125I in several animal tumor models.


METHODS
Experiments were conducted using mice bearing an intraperitoneal ovarian tumor (*IUdR by intracavitary injection), and rats bearing either bladder cancer (*IUdR by intravesical injection), brain gliosarcomas (intratumoral injection), or intrathecal gliosarcomas (intrathecal injection).


RESULTS
After locoregional administration, [123I]IUdR and [125I]IUdR localize within tumor, clear rapidly from the rest of the body and are therapeutically effective.


CONCLUSIONS
When labeled with the Auger electron emitter 123I or 125I, IUdR demonstrates therapeutic efficacy. In addition, [123I]IUdR has a potential role in the scintigraphic detection of cancer.
Kassis
A I
AI
Harvard Medical School, Boston, Massachusetts, USA.
Adelstein
S J
SJ
D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy; D005260:Female; D018316:Gliosarcoma / Q000532:radiotherapy; D007065:Idoxuridine / Q000627:therapeutic use*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D051379:Mice; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D010051:Ovarian Neoplasms / Q000532:radiotherapy; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy
D007457:Iodine Radioisotopes; D007065:Idoxuridine