title: [2 cases of Whipple disease with different outcomes].
abstract: Whipple's disease is a rare infectious disease with systemic manifestation on different organs. In 1992 the typical rod-shaped bacillus was identified as a gram-negative actinomycete with distinctive morphologic characteristics and named as Tropheryma whippelii. The diagnosis is established by demonstrating the presence of PAS-positive macrophages in the mucosa, with large cytoplasmatic granules. We present two cases of Whipple's disease with different outcomes. Both were treated with the same antibiotics (penicillin/streptomycin). With this treatment one patient recovered completely. In a follow-up over 7 years no relapse occurred. The second patient died only 4 weeks after the diagnosis was established.
authors.affiliation: Medizinische Klinik, Kantonsspital Liestal.
authors.forename: A
authors.initials: A
authors.lastname: Rowedder
authors.forename: S
authors.initials: S
authors.lastname: Bauer
authors.forename: W
authors.initials: W
authors.lastname: Wegmann
authors.forename: P
authors.initials: P
authors.lastname: Schlup
authors.forename: R
authors.initials: R
authors.lastname: Meier
mesh_terms: D000193:Actinomycetales Infections / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004386:Duodenum / Q000166:cytology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage; D013307:Streptomycin / Q000008:administration & dosage; D016896:Treatment Outcome; D008061:Whipple Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D013307:Streptomycin
vernacular_title: Zwei Fälle von Morbus Whipple mit unterschiedlichem Verlauf.