Possible effect of air pollutants (Mexico City) on superoxide dismutase activity and serum lipoperoxides in the human adult.
The action of air pollutants, through their constituents, (O3, NO2, tobacco smoke) are capable of causing damage due to their lipoperoxidative properties or, indirectly, by inducing production of free radicals. As a consequence of photochemical processes, the ozone levels in the atmosphere of Mexico City are generally higher (mean of 0.325 ppm; period between 1987-1992) and may be harmful to health. Sixty two volunteers (medical doctors), aged 27-32 years, were divided into three groups. Group A was composed of those persons (17) who had never lived in Mexico City; a second group (B) (21) had recently arrived in Mexico City (1-8 days); and a third group (C) (24) who had permanently resided in Mexico City. Serum was obtained from fresh whole blood. Superoxide dismutase (SOD) activity and thiobarbituric acid-reactive materials were higher in group B while chromolipids and the serum inhibitory capacity (for lipoperoxidation) was higher in group C. The acute exposure to pollutants in group B apparently may have induced SOD as an antioxidant defense and was responsible for the increased level of TBA reactive material. In group C, the significant finding is better antioxidative defenses and slightly higher chromolipids.
Hicks
J J
JJ
Unidad de Investigación Médica en Bioguímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F.
Medina-Navarro
R
R
Guzman-Grenfell
A
A
Wacher
N
N
Lifshitz
A
A
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008800:Mexico; D013482:Superoxide Dismutase / Q000378:metabolism*
D000393:Air Pollutants; D008054:Lipid Peroxides; D013482:Superoxide Dismutase