title: [Cancers of the base of the tongue and hypopharynx: results of a multicenter randomized trial of chemotherapy prior to locoregional treatment].
abstract: The authors report the results of a multicentric randomised trial assessing the effects on survival of neoadjuvant chemotherapy with cisplatin (100 mg/m2, D1) and fluorouracil (1 g/m2, D2-4) delivered before regional treatment in patients with squamous cell carcinoma of hypopharynx and base of tongue. 133 patients were enrolled in the study, and 121 were included in the analysis, 64 in group A (regional treatment alone) and 27 in group B (chemotherapy followed by regional treatment). Despite a high objective response rate to chemotherapy (primary tumour: 85%, 24% complete; nodes: 63%), overall survival was not significantly higher in group B than in group A.
authors.affiliation: CRLCC Eugène-Marquis, Rennes, France.
authors.forename: D
authors.initials: D
authors.lastname: Gedouin
authors.forename: P
authors.initials: P
authors.lastname: Desprez
authors.forename: J J
authors.initials: JJ
authors.lastname: Perron
authors.forename: F
authors.initials: F
authors.lastname: Fleury
authors.forename: G
authors.initials: G
authors.lastname: Leclech
authors.forename: L
authors.initials: L
authors.lastname: Miglianico
authors.forename: D
authors.initials: D
authors.lastname: Belpomme
authors.forename: C
authors.initials: C
authors.lastname: Chenal
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D011879:Radiotherapy Dosage; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Cancers de la base de langue et de l'hypopharynx: résultats d'un essai multicentrique randomisé de chimiothérapie avant traitement locorégional.