[The modifying effect of long-term administration of ascorbic acid with drinking water on asbestos-induced pleural carcinogenesis in Wistar rats].
Ascorbic acid administered with drinking water, in a concentration of 2.5%, together with sucrose (1%) was found to significantly inhibit the development of mesothelial and pleural tumors induced in Wistar rats by asbestos treatment. Said agents, however, failed to influence spontaneous carcinogenesis.
Stadnikova
N M
NM
Vasil'eva
L A
LA
Shelepov
V P
VP
Pylev
L N
LN
D000284:Administration, Oral; D000818:Animals; D001194:Asbestos; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000517:prevention & control; D018301:Neoplasms, Mesothelial / Q000517:prevention & control; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014867:Water
D014867:Water; D001194:Asbestos; D001205:Ascorbic Acid
Modifikatsiia plevral'nogo asbestovogo kantserogeneza u krys Vistar dlitel'nym vvedeniem s pit'evoĭ vodoĭ askorbinovoĭ kisloty.