title: Biomaterials for primary closure of a choledochotomy in dogs.
abstract: Since primary closure of the common bile duct is often not undertaken because of the risks of biliary leakage and peritonitis, we have evaluated feasibility and reliability of closure using biomaterials. In three groups of dogs, an unsutured choledochotomy was closed with circular glued patches: a scleroprotein patch in 4 dogs and an oxidized, compressed human collagen patch reinforced (n = 6) or not (n = 6) with three stitches. The scleroprotein patch (n = 4) was resorbed too soon, and in 2 dogs the unstitched collagen patches became unglued; biliary leakage was the result in both instances. The bile duct healed successfully within 1 month in the other 10 animals fitted with collagen patches, despite one common bile duct stricture. Safe primary closure of a choledochotomy may be envisioned in humans if the duct suture is protected by this new collagen biomaterial.
authors.affiliation: Département de Chirurgie A, Hôpitaux Universitaires, Strasbourg, France.
authors.forename: D
authors.initials: D
authors.lastname: Mutter
authors.forename: M
authors.initials: M
authors.lastname: Aprahamian
authors.forename: S
authors.initials: S
authors.lastname: Evrard
authors.forename: C
authors.initials: C
authors.lastname: Damgé
authors.forename: J
authors.initials: J
authors.lastname: Marescaux
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D003135:Common Bile Duct / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D005260:Female; D006801:Humans
chemical_list: D001672:Biocompatible Materials; D003094:Collagen