[Colchicinoids--their toxicity and biological activity].
The cytotoxicity of 32 colchicinoids in isolated rat hepatocytes was studied. Their effect was examined by biochemical parameters-lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, lipid peroxidation and by changes in reduced glutathione level. Only compounds with methylsulfonyl group at C-10 were significantly hepatotoxic.
Ondra
P
P
Institut für Gerichtsmedizin und medizinisches Recht, Medizinische Fakultät, Palacký Universität, Olomouc, Ischechische Republik.
Ulrichová
J
J
D000818:Animals; D002478:Cells, Cultured; D003078:Colchicine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D003078:Colchicine
Colchicinoide--ihre Toxizität und Biologische aktivität.