[Simple glycine derivatives from lipid transporter systems of glycine. Carrier test of a small-size neutral acid amine to the central nervous system].
Glycine, an important amino acid, does not cross the blood-brain barrier. Some simple derivatives have been designed to improve the unfavourable physico-chemical parameters: N-benzyloxycarbonylglycine and its methyl ester exhibit anticonvulsant activities superior to the parent amino acid. The incorporation of N-benzyloxycarbonylglycine in a pseudo-triglyceride pattern led to more active substances.
Lambert
D M
DM
Laboratoire de Chimie pharmaceutique, Département des Sciences pharmaceutiques de l'Université catholique de Louvain.
D000927:Anticonvulsants / Q000378:metabolism; D001812:Blood-Brain Barrier; D015195:Drug Design; D005998:Glycine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D006801:Humans; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D000927:Anticonvulsants; D009842:Oligopeptides; D014280:Triglycerides; C091923:benzyloxycarbonyl-dimethylglycyl-diphenylglycyl-glycine methyl ester; D005998:Glycine
Des dérivés simples de la glycine aux systèmes lipidiques transporteurs de glycine. Essai de vectorisation d'un aminé neutre de petite taille vers le système nerveux central.