The effect of TGF-beta 1 and TGF-beta 2 on the proliferation of human Tenon's capsule fibroblasts in tissue culture.
This study examines the effect of transforming growth factor beta 1 and 2 (TGF-beta 1 and TGF-beta 2) on the proliferation of human Tenon's capsule fibroblasts in tissue culture. Both TGF-beta 1 and TGF-beta 2 were shown to stimulate proliferation at 1000 and 100 pg/ml concentrations. We discuss the significance of these findings with respect to wound healing following trabeculectomy, and postulate why some eyes are more at risk of failure than others.
Cunliffe
I A
IA
Department of Ophthalmology and Orthoptics, Royal Hallamshire Hospital, Sheffield, UK.
Rees
R C
RC
Rennie
I G
IG
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003238:Connective Tissue / Q000187:drug effects*; D003239:Connective Tissue Cells; D046508:Culture Techniques; D005205:Fascia / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D014130:Trabeculectomy; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014945:Wound Healing
D016212:Transforming Growth Factor beta