title: [Antineutrophil cytoplasmic autoantibodies (ANCA)--in patients with connective tissue diseases].
abstract: Antineutrophil cytoplasmic autoantibodies (ANCA) attack primary cytoplasmic granules of neutrophil leukocytes and lysosomes of monocytes. Indirect immunofluorescence technique distinguished two types of ANCA: genuine of cytoplasmic (c-ANCA) and perinuclear (p-ANCA). ANCA were followed up at patients with systemic connective tissue diseases who underwent a treatment at Department of Rheumatology and Clinical Immunology of Clinical Hospital Osijek. p-ANCA were found at 15 patients. Its titre dependent upon the stage of the disease. This very finding pointed out the importance of ANCA not only as a valid additional diagnostic factor but as a strong prognostic marker in particular systemic connective tissue diseases as well.
authors.affiliation: Interna klinika Klinicke Osijek.
authors.forename: V
authors.initials: V
authors.lastname: Prus
authors.forename: K
authors.initials: K
authors.lastname: Sram
authors.forename: V
authors.initials: V
authors.lastname: Fustar
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D003240:Connective Tissue Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies
vernacular_title: Antineutrofilna citoplazmatska autoantitijela (ANCA)--u bolesnika sa sustavnim bolestima vezivnog tkiva.