title: Efficacy of disinfectants against biofilm cells of methicillin-resistant Staphylococcus aureus.
abstract: The effect of disinfectants on biofilm cells of methicillin-resistant Staphylococcus aureus (MRSA) was evaluated. Eradication of biofilm cells of MRSA by chlorhexidine gluconate, benzalkonium chloride, alkyldiaminoethyl glycine and sodium hypochlorite required a much longer time than that of planktonic cells in suspensions. Benzalkonium chloride (0.1%) and alkyldiaminoethyl glycine (0.1%) were ineffective for eradication of biofilm cells even after 1 h, but were effective for eradication of planktonic cells within 20 s. Sodium hypochlorite (0.01%) was also ineffective for eradication of biofilm cells even after 30 min, but was lethal to planktonic cells within 20 s.
authors.affiliation: Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oie
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: A
authors.initials: A
authors.lastname: Kamiya
authors.forename: H
authors.initials: H
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D016106:Methicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D004202:Disinfectants