[Assessment of effectiveness of AgSD-ZnSD-Azone cream, negative ion irradiation and "moisture burn ointment" in prevention of burn wound infection as judged by changes in LPS, TNF and ET levels].
40 Wistar rats were scalded resulting in 15% TBSA full-thickness burn. Pseudomonas aeruginosa (10(9)/ml) was seeded on the wounds. The animals were divided into 4 groups. AgSD and ZnSD (with Azone) cream was applied to the wounds in the group I. The wounds were irradiated with negative ion current in the group II. The "moisture burn ointment" was applied to the wounds in the group III. Group IV consisted of controls without any treatment. Judging by changes in levels of LPS, TNF and ET, it was shown that the best result was obtained in the group I and II. The "moisture burn ointment" group yielded the poorest results.
Sun
S
S
304th Hospital of People's, Liberation Army, Beijing.
Guo
Z
Z
Yang
H
H
D000818:Animals; D002056:Burns / Q000097:blood / Q000628:therapy*; D016232:Endothelins / Q000097:blood; D008070:Lipopolysaccharides / Q000097:blood*; D009824:Ointments; D011552:Pseudomonas Infections / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D018030:Silver Compounds / Q000008:administration & dosage*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014946:Wound Infection / Q000517:prevention & control*; D017967:Zinc Compounds / Q000008:administration & dosage*
D016232:Endothelins; D008070:Lipopolysaccharides; D009824:Ointments; D018030:Silver Compounds; D014409:Tumor Necrosis Factor-alpha; D017967:Zinc Compounds