Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen.
Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.
Brill
G M
GM
Abbott Laboratories, Abbott Park, Il. 60064, USA.
Kati
W M
WM
Montgomery
D
D
Karwowski
J P
JP
Humphrey
P E
PE
Jackson
M
M
Clement
J J
JJ
Kadam
S
S
Chen
R H
RH
McAlpine
J B
JB
D002782:Cholestenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005670:Fusarium; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C100702:A 108835; C100701:A 108836; D002782:Cholestenes; D011480:Protease Inhibitors; D014315:Triterpenes