title: Acquired generalized hypohidrosis/anhidrosis with subclinical Sjögren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis.
abstract: The pathogenesis and the underlying pathologic changes of acquired generalized hypohidrosis/anhidrosis (AGHA) are largely unknown. We studied a case of AGHA in a young woman suffering from heat intolerance and progressive loss of sweating. Pathologic study of affected skin revealed unique syringolymphoid hyperplasia with T cell infiltration, suggesting a T cell-mediated autoimmune disease. The patient also had subclinical Sjögren's syndrome and diffuse hair loss. The pathogenesis of the latter two conditions is believed to be related to the patient's AGHA.
authors.affiliation: Department of Dermatology, Chang Gung College of Medicine and Technology, Kwei San, Tao Yuan, Taiwan.
authors.forename: C L
authors.initials: CL
authors.lastname: Huang
authors.forename: T T
authors.initials: TT
authors.lastname: Kuo
authors.forename: H L
authors.initials: HL
authors.lastname: Chan
mesh_terms: D000328:Adult; D000505:Alopecia / Q000276:immunology / Q000473:pathology; D001327:Autoimmune Diseases / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007007:Hypohidrosis / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D012793:Sialadenitis / Q000276:immunology / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*; D013545:Sweat Glands / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology