title: Improved haemodynamic stability with administration of aprotinin during orthotopic liver transplantation.
abstract: In a placebo-controlled, double-blind study, we have investigated the hypothesis that patients for orthotopic liver transplantation (OLT) treated with high-dose aprotinin (serum concentrations > or = 200 kiu ml-1) show greater haemodynamic stability on graft reperfusion. We studied 55 adult patients presenting for OLT, and 52 were included in the analysis. The treatment and placebo groups were similar in patient characteristics. The anaesthetic regimen used was standardized, and veno-venous bypass were used in all patients. Cardiac output measurements and haemodynamic profiles were recorded at intervals throughout anaesthesia and surgery. Arterial and mixed venous oxygen saturations were measured by co-oximetry. Derived variables were measured using standard formulae. Aprotinin treated patients had greater values for systemic vascular resistance on reperfusion, with a lesser cardiac index and calculated oxygen delivery. Oxygen consumption, however, was significantly greater, despite reduced delivery.
authors.affiliation: Department of Anaesthetics and Liver Transplantation, Kings College Hospital, London.
authors.forename: S J
authors.initials: SJ
authors.lastname: Milroy
authors.forename: S
authors.initials: S
authors.lastname: Cottam
authors.forename: K C
authors.initials: KC
authors.lastname: Tan
authors.forename: I
authors.initials: I
authors.lastname: Hilmi
authors.forename: B
authors.initials: B
authors.lastname: Oyesola
mesh_terms: D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000097:blood / Q000627:therapeutic use*; D002302:Cardiac Output / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D015424:Reperfusion; D015842:Serine Proteinase Inhibitors / Q000097:blood / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D015842:Serine Proteinase Inhibitors; D007611:Aprotinin; D010100:Oxygen