title: [Hypothyroidism following radiosurgical treatment of cancers of the hypopharynx].
abstract: In a series of 224 patients treated between 1980 and 1992 for hypopharyngeal carcinoma by surgery and post postoperative radiotherapy we found an overall 54% incidence of elevated TSH levels. Decreased FT4 levels were associated in about one-third of the patients. When thyroidectomy was performed, 71% of the patients developed thyroid dysfunction. Most TSH abnormalities (45%) occurred within two years of treatment. Nevertheless, long-term followup is indicated since those complications may be delayed. Hormonal replacement therapy is recommended for patients with elevated TSH.
authors.affiliation: Département de radiothérapie, Strasbourg, France.
authors.forename: G M
authors.initials: GM
authors.lastname: Jung
authors.forename: J P
authors.initials: JP
authors.lastname: Wagner
authors.forename: O
authors.initials: O
authors.lastname: Ernest
authors.forename: O
authors.initials: O
authors.lastname: Schneegans
authors.forename: A
authors.initials: A
authors.lastname: Gentine
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D007037:Hypothyroidism / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology / Q000528:radiation effects / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin
vernacular_title: Hypothyroïdie après traitement radiochirurgical des cancers de l'hypopharynx.