Metabolism of daidzein and genistein by intestinal bacteria.
The isoflavones daidzein [1] and genistein [2] were fermented with human fecal bacteria under anaerobic conditions. Dihydrodaidzein [3], benzopyran-4,7-diol,3-(4-hydroxyphenyl) [4], and equol [5] were isolated from the fermentation broth of 1. Only one metabolite, dihydrogenistein [6], was isolated and characterized from the fermentation broth of 2. Metabolites 3-6 were identified by spectral methods.
Chang
Y C
YC
Department of Horticulture and Pesticide Research Center, Michigan State University, East Lansing 48824, USA.
Nair
M G
MG
D001419:Bacteria / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D019833:Genistein; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D007529:Isoflavones / Q000737:chemistry / Q000378:metabolism*
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; C004742:daidzein; D019833:Genistein