[Myelofibrosis complicated by T-cell lymphoma followed by leukemic transformation].
A 37-year-old man was admitted because of pancytopenia with leukoerythroblastosis and anisocytosis in January 1986. Bone marrow aspiration resulted in a dry tap and biopsy showed marked myelofibrosis. Three months after admission, generalized lymph node swelling and multiple skin tumors were recognized. A biopsied lymph node revealed lymphoblastic lymphoma. The surface markers of lymphoma cells showed an immature T-cell phenotype, whereas T-cell receptor beta and gamma chain genes showed germ line configuration. The patient was treated with combination chemotherapy in June 1986. A month later, he developed leukemic transformation with features of acute myelocytic leukemia and he died of pneumonia. Autopsy disclosed extramedullary hematopoiesis in the liver and spleen. Primary myelofibrosis complicated by T-cell lymphoma is extremely rare.
Nakase
K
K
Department of Internal Medicine, Yamada Red Cross Hospital, Japan.
Hasegawa
M
M
Suzuki
Y
Y
Tamaki
S
S
Tanigawa
M
M
Ikeda
T
T
Tsuji
K
K
Miyanishi
E
E
D000328:Adult; D002471:Cell Transformation, Neoplastic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008297:Male; D055728:Primary Myelofibrosis / Q000473:pathology*