Primary adenocarcinoma of the ureter. Case report with immunohistochemical characterization.
Genuine adenocarcinomas of the ureter are rare tumors and have to be distinguished from other gland-forming malignancies arising from the transitional epithelium, due to the poor clinical outcome. The histopathological features of a tumor combined with intestinal metaplasia of the adjacent urothelium are described. The tumor has to be distinguished from transitional cell cancer with glandular metaplasia, muco-urothelial cancer, microcystic transitional cell cancer and transitional cell cancer with mucoid cytoplasmatic inclusions. Immunohistochemical analysis of the cancer shows positivity for carcinoembryonic antigen and a staining pattern characteristic for adenocarcinomas. The expression of keratin types 7 and 13, which is typically found in transitional cell carcinomas, is lost.
Haitel
A
A
Department of Pathology, University of Vienna, Austria.
Wiener
H G
HG
Susani
M
M
D000230:Adenocarcinoma / Q000737:chemistry* / Q000175:diagnosis; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000737:chemistry; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D008679:Metaplasia / Q000175:diagnosis; D018396:Mucin-1 / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D014516:Ureteral Neoplasms / Q000737:chemistry* / Q000175:diagnosis
D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D009363:Neoplasm Proteins; D007633:Keratins