The use of GnRH agonists in the treatment of endometriomas with or without drainage.
To assess the efficacy of GnRH-agonist therapy in the treatment of endometriomas with or without surgical intervention, 26 women with laparoscopically proven endometriomas larger than 3 cm were recruited to the study. Fourteen women with 19 endometriomas (5 bilateral), had drainage of endometrioma at initial laparoscopy. After the procedure, ovarian suppression was done with GnRH-a therapy for 6 months. The second group which consisted of 12 women, had 17 endometriomas. No surgical procedure was performed. They received only GnRH-a therapy for 6 months. On repeat laparoscopy, in the first group, the rates of decrease in ovarian AFS scores of endometriomas and complete resolution were found as 100% and 37% respectively. In the second group the response was only 18% (p < 0.0001). It was concluded that drainage of the cyst (surgical therapy) combined with postoperative GnRH-a suppression is a better treatment modality than the use of GnRH-a (medical therapy) alone for endometriomas.
Batioglu
S
S
Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
Celikkanat
H
H
Ugur
M
M
Mollamahmutoglu
L
L
Yesilyurt
H
H
Kundakci
M
M
D000328:Adult; D003131:Combined Modality Therapy; D004322:Drainage; D004715:Endometriosis / Q000628:therapy*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000628:therapy*; D017329:Triptorelin Pamoate / Q000008:administration & dosage* / Q000009:adverse effects
D017329:Triptorelin Pamoate