title: Localization of the gene for Cowden disease to chromosome 10q22-23.
abstract: Cowden disease (CD) (MIM 158350), or multiple hamartoma syndrome, is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer. Its clinical features include a wide array of abnormalities but the main characteristics are hamartomas of the skin, breast, thyroid, oral mucosa and intestinal epithelium. The pathognomonic hamartomatous features of CD include multiple smooth facial papules, acral keratosis and multiple oral papillomas. The pathological hallmark of the facial papules are multiple trichilemmomas. Expression of the disease is variable and penetrance of the dermatological lesions is assumed to be virtually complete by the age of twenty. Central nervous system manifestations of CD were emphasized only recently and include megalencephaly, epilepsy and dysplastic gangliocytomas of the cerebellum (Lhermitte-Duclos disease, LDD). Early diagnosis is important since female patients with CD are at risk of developing breast cancer. Other lesions include benign and malignant disease of the thyroid, intestinal polyps and genitourinary abnormalities. To localize the gene for CD, an autosomal genome scan was performed. A total of 12 families were examined, resulting in a maximum lod score of 8.92 at theta = 0.02 with the marker D10S573 located on chromosome 10q22-23.
authors.affiliation: Department of Neurology, University Hospital Nijmegen, The Netherlands.
authors.forename: M R
authors.initials: MR
authors.lastname: Nelen
authors.forename: G W
authors.initials: GW
authors.lastname: Padberg
authors.forename: E A
authors.initials: EA
authors.lastname: Peeters
authors.forename: A Y
authors.initials: AY
authors.lastname: Lin
authors.forename: B
authors.initials: B
authors.lastname: van den Helm
authors.forename: R R
authors.initials: RR
authors.lastname: Frants
authors.forename: V
authors.initials: V
authors.lastname: Coulon
authors.forename: A M
authors.initials: AM
authors.lastname: Goldstein
authors.forename: M M
authors.initials: MM
authors.lastname: van Reen
authors.forename: D F
authors.initials: DF
authors.lastname: Easton
authors.forename: R A
authors.initials: RA
authors.lastname: Eeles
authors.forename: S
authors.initials: S
authors.lastname: Hodgsen
authors.forename: J J
authors.initials: JJ
authors.lastname: Mulvihill
authors.forename: V A
authors.initials: VA
authors.lastname: Murday
authors.forename: M A
authors.initials: MA
authors.lastname: Tucker
authors.forename: E C
authors.initials: EC
authors.lastname: Mariman
authors.forename: T M
authors.initials: TM
authors.lastname: Starink
authors.forename: B A
authors.initials: BA
authors.lastname: Ponder
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
authors.forename: H
authors.initials: H
authors.lastname: Kremer
authors.forename: M
authors.initials: M
authors.lastname: Longy
authors.forename: C
authors.initials: C
authors.lastname: Eng
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012984:Software
chemical_list: D005819:Genetic Markers