[The preventive role of large doses of aprotinin in decreasing the degree of metabolic disorders during aortocoronary bypass operations].
A total of 100 patients were subjected to multiple aortocoronary shunting using autovein and/or internal thoracic artery under conditions of artificial circulation. In a double blind test, all the patients were administered either aprotinin (group 1, n = 50) or placebo (group 2, n = 50). The groups were matched for duration of surgery, number of shunts, duration of artificial circulation and aorta clamping, age, and body weight. Our results indicate that intraoperative prolonged infusion of high (6.0 million KIU) aprotinin doses reduced the incidence and severity of disorders of pulmonary oxygenation function; improved, despite an increase of diuresis, the function of the kidneys, and reduced the severity of circulatory hypoxia caused by both artificial circulation and acute circulatory disorders in the intra- and early postoperative period.
Dement'eva
I I
II
Charnaia
M A
MA
Dzemeshkevich
S L
SL
Ziuliaeva
T P
TP
D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D007431:Intraoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D013997:Time Factors
D006490:Hemostatics; D007611:Aprotinin
Preventivnaia rol' bol'shikh doz aprotinina v snizhenii narusheniĭ metabolizma pri operatsiiakh aortokoronarnogo shuntirovaniia.