Immunoglobulin diversity: rearranging by cutting and repairing.
The recombination process that assembles antigen-receptor genes is now understood in some biochemical detail. The initial steps reflect a common theme seen in retroviral integration and prokaryotic transposition, and the later steps involve the enzymatic machinery for double-strand break DNA repair.
Lieber
M
M
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
D000818:Animals; D004260:DNA Repair; D015321:Gene Rearrangement; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics* / Q000276:immunology
D007136:Immunoglobulins