title: A clinical and patch test study of contact dermatitis from traditional Chinese medicinal materials.
abstract: Putative allergens in, clinical manifestations of, and patch tests with traditional Chinese medicinal materials (CMM) causing contact dermatitis (CD) were studied. 14 patients with CMM CD and 351 controls were patch tested with the standard series of allergens of Beijing Medical University and the suspected drug, as is. It was found that most CMM CD was caused by the CMM frequently used topically for analgesic and anti-inflammatory effect. All patients patch tested with the suspected drug gave positive results. Some patients also reacted to fragrance mix, colophony, rubber mix and ammoniated mercury. The positivity rates of fragrance mix and colophony in CMM CD patients were significantly higher than in controls (55.6% versus 16.5% for fragrance mix, chi 2 = 11.86, p < 0.01; and 55.6% versus 5.1% for colophony, chi 2 = 29.35, p < 0.01), while not those of rubber mix and ammoniated mercury. Results indicated that the topical analgesic and anti-inflammatory CMM, especially those containing fragrance, may cause contact sensitization. Clinical findings in CMM CD included cutaneous irritation, allergic contact dermatitis, immediate contact reactions and systemic contact dermatitis. CMM CD can be diagnosed by patch testing the putative drug, as is.
authors.affiliation: Department of Dermatology, Third Hospital of Beijing Medical University, PR China.
authors.forename: L F
authors.initials: LF
authors.lastname: Li
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000641:Ammonia / Q000009:adverse effects; D000700:Analgesics / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology; D017453:Dermatitis, Irritant / Q000175:diagnosis / Q000209:etiology; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008627:Mercuric Chloride / Q000009:adverse effects; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D012116:Resins, Plant / Q000009:adverse effects; D012408:Rubber / Q000009:adverse effects; D013638:Tars / Q000009:adverse effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D010476:Perfume; D012116:Resins, Plant; D013638:Tars; D008627:Mercuric Chloride; D000641:Ammonia; C013893:rosin; D012408:Rubber; C028431:mercuric chloride, ammoniated