Different effects of acute administration of aminophylline and nitroglycerin on exercise capacity in patients with syndrome X.
To investigate the effects of the acute administration of aminophylline and nitroglycerin on effort ischemia, 20 patients with syndrome X underwent 3 bicycle exercise tests after sublingual nitroglycerin (0.3 mg) and after 90 minutes of oral administration of aminophylline (400 mg). Compared with the basal test, only aminophylline induced a significant increase in the time to ischemic threshold and to angina; these findings support the potential therapeutic role of this adenosine receptor blocking agents and suggest a possible role of "steal phenomenon" in the pathogenesis of effort angina in patients with syndrome X.
Radice
M
M
Clinical Methodology, University of Milan, Division of Cardiology, Seriate, Italy.
Giudici
V
V
Pusineri
E
E
Breghi
L
L
Nicoli
T
T
Peci
P
P
Giani
P
P
De Ambroggi
L
L
D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000503:physiopathology*; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D018047:Receptors, Purinergic P1 / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D002316:Cardiotonic Agents; D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D000628:Aminophylline; D005996:Nitroglycerin