title: Structures of prokaryotic ribosomal proteins: implications for RNA binding and evolution.
abstract: After a long hiatus, the pace of determination of the structures of ribosomal proteins has accelerated dramatically. We discuss here the structures of five ribosomal proteins from Bacillus stearothermophilus: S5, S17, L6, L9, and L14. These structures represent several new motifs. Each of these structures has revealed new insights, and we have developed criteria for recognizing RNA-binding regions of each protein and correlating the structures with such properties as antibiotic resistance. The information here should also prove invaluable in an eventual high-resolution picture of the intact ribosome.
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
authors.forename: C
authors.initials: C
authors.lastname: Davies
authors.forename: S E
authors.initials: SE
authors.lastname: Gerchman
authors.forename: B L
authors.initials: BL
authors.lastname: Golden
authors.forename: D W
authors.initials: DW
authors.lastname: Hoffmann
authors.forename: T N
authors.initials: TN
authors.lastname: Jaishree
authors.forename: J H
authors.initials: JH
authors.lastname: Kyila
authors.forename: S
authors.initials: S
authors.lastname: Porter
authors.forename: S W
authors.initials: SW
authors.lastname: White
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D005075:Biological Evolution; D001411:Geobacillus stearothermophilus / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D012269:Ribosomal Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins