Ultraviolet light and immunity to coelenterate venom.
Peripheral blood lymphocytes from sensitized persons proliferate in response to naturally occurring (coelenterate) venoms. Ultraviolet exposure decreases the proliferation. This decrease is widespread and also extends to responses against pathogens, mitogens, and endogenous proteins. Ultraviolet exposure alters human immunity by many means, including affecting circulating T-cells. Since venoms act by immunologic as well as toxic pathways, any abrogation of normal immunity could enhance their action on man.
Miura
S
S
University of Maryland School of Medicine, Baltimore, USA.
Burnett
J W
JW
Aurelian
L
L
D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D003064:Cnidarian Venoms / Q000494:pharmacology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects*; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects
D003064:Cnidarian Venoms