title: Harmful effects of MSG on function of hypothalamus-pituitary-target gland system.
abstract: It has been demonstrated that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus (AN) of the hypothalamus. The present study shows that fat was accumulated in the abdomen of male rats treated with MSG; weights of the body, pituitary and testis were lower; beta-EP content in hypothalamus decreased while L.EnK content increased; serum LH, FSH, TSH, GH and TS levels all decreased in varying degrees while serum PRL level significantly increased. The cAMP content lowered in pituitary, but nor in testes; clear histological changes occurred in testicular tissue; Se-GSH-Px activity in both testis and adrenal gland lowered while LPO level significantly increased. Both Se-GSH-Px activity and LPO level in liver increased. These results indicate that MSG is harmful to the function of the hypothalamus-pituitary-target system of neonatal rats.
authors.affiliation: Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Gong
authors.forename: F Q
authors.initials: FQ
authors.lastname: Xia
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: X Y
authors.initials: XY
authors.lastname: Li
authors.forename: T H
authors.initials: TH
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Lu
authors.forename: S Z
authors.initials: SZ
authors.lastname: Liu
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000473:pathology
chemical_list: D012970:Sodium Glutamate