In vivo effects of 13-cis retinoic acid treatment on the concentration of proteins and lipids in serum.
A number of serum components, whose concentrations or gene expression have been shown to be modulated by all-trans retinoic acid in vitro, were monitored in patients before and during treatment with Roaccutane (13-cis retinoic acid, 40-60 mg/day) for severe acne. The 13-cis retinoic acid concentration in serum rose from 5.25 +/- 1.09 to 593 +/- 65 nmol/l (mean +/- SD) 24 h after the latest dose. The concentration of all-trans retinoic acid in serum under Roaccutane treatment was measured in model experiments and shown to be 10-20 nmol/l i.e., 2-4 times the basal levels (4.65 +/- 0.85 nmol/l) when the 13-cis retinoic acid concentration was 370-980 nmol/l. The concentrations of creatine kinase-MB, apolipoprotein B, total cholesterol and LDL cholesterol increased significantly while the other measured serum components, including lipoprotein lipase activity, were unaffected by Roaccutane treatment.
Fex
G A
GA
Department of Clinical Chemistry, Lund University Hospital, Sweden.
Aronsson
A
A
Andersson
A
A
Larsson
K
K
Nilsson-Ehle
P
P
D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D001798:Blood Proteins / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes; D015474:Isotretinoin / Q000097:blood / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000097:blood
D001055:Apolipoproteins B; D001798:Blood Proteins; D008078:Cholesterol, LDL; D007527:Isoenzymes; D008055:Lipids; D014212:Tretinoin; D002784:Cholesterol; D003402:Creatine Kinase; D015474:Isotretinoin