Role of endothelin in renal function and dysfunction.
1. Endothelin has significant effects on renovascular, glomerular and tubular function. 2. Endothelin causes severe renal vasoconstriction, resulting in a decrease in renal blood flow and glomerular filtration rate. 3. Endothelin can inhibit sodium reabsorption and, in the rat, vasopressin-induced water transport. 4. The endothelin receptor subtypes mediating renovascular and tubular effects of endothelin may differ between species. 5. Renal endothelin production, metabolism and receptor binding is altered in a number of renal diseases, including acute and chronic renal failure and cyclosporine and radiocontrast nephrotoxicity. 6. Endothelin receptor antagonists or antibodies can attenuate the severity or progression of a number of renal diseases.
Brooks
D P
DP
Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA.
D058186:Acute Kidney Injury / Q000209:etiology; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects; D016572:Cyclosporine / Q000009:adverse effects; D016232:Endothelins / Q000502:physiology*; D007511:Ischemia / Q000150:complications / Q000209:etiology; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D012079:Renal Circulation / Q000502:physiology; D014661:Vasoconstriction
D003287:Contrast Media; D016232:Endothelins; D016572:Cyclosporine