RNA editing: how a message is changed.
Considerable progress has been made in unraveling the mechanistic features of RNA editing processes in a number of genetic systems. Recent highlights include the identification of the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme as a zinc-dependent cytidine deaminase that binds to RNA, the demonstration that adenosines in brain glutamate receptor pre-mRNAs are converted into inosines and that double-stranded RNA A deaminase (dsRAD), the candidate enzyme, is another zinc-dependent RNA nucleotide deaminase, and a mounting body of evidence for a cleavage-ligation mechanism for U insertion/deletion editing in kinetoplastid protozoa.
Benne
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Department of Biochemistry, Faculty of Medicine, University of Amsterdam, Academic Medical Centre, The Netherlands. Sloof@amc.uva.nl
D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics; D001483:Base Sequence; D008928:Mitochondria / Q000235:genetics; D008969:Molecular Sequence Data; D009700:Nucleoside Deaminases / Q000502:physiology; D012313:RNA / Q000235:genetics; D017393:RNA Editing / Q000235:genetics*; D000077278:RNA, Mitochondrial; D017470:Receptors, Glutamate / Q000235:genetics
D001055:Apolipoproteins B; D000077278:RNA, Mitochondrial; D017470:Receptors, Glutamate; D012313:RNA; D009700:Nucleoside Deaminases