title: Lymphocyte subsets in the endometrium of genitally normal mares and mares susceptible to endometritis.
abstract: The density and distribution of MHC Class II positive cells and subpopulations of lymphocytes were studied in the endometrium of genitally normal mares and mares susceptible to endometritis. In genitally normal mares, more MHC Class II positive cells were present in the epithelium and stratum compactum during oestrus than dioestrus. Significantly more CD4+ and CD8+ lymphocytes were present in the stratum compactum than in the stratum spongiosum. CD4+ lymphocytes were present in greater numbers than CD8+ lymphocytes in the stratum compactum but approximately equal numbers were present in the stratum spongiosum and in lymphoid aggregates. Occasional CD4+ and CD8+ cells were seen in the luminal and glandular epithelium. Infrequently, B cells were present in the endometrium and were not observed in the epithelium. Numbers of T and B cells did not appear to be affected by cycle stage. In mares with endometritis, the densities of CD4+, CD8+ and B cells were significantly increased. Large aggregates of lymphoid cells which contained approximately twice as many CD4+ cells as CD8+ cells were present in the endometrium of these mares and all 3 subclasses of lymphocyte were seen occasionally in luminal and glandular epithelium.
authors.affiliation: Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, Roslin, Midlothian, UK.
authors.forename: E D
authors.initials: ED
authors.lastname: Watson
authors.forename: S R
authors.initials: SR
authors.lastname: Thomson
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000473:pathology; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D004716:Endometritis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D004717:Endometrium / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D004971:Estrus / Q000502:physiology; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006734:Horse Diseases / Q000276:immunology / Q000473:pathology*; D006736:Horses / Q000276:immunology* / Q000502:physiology; D007150:Immunohistochemistry; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000473:pathology
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D000949:Histocompatibility Antigens Class II