Natural killer cell receptors specific for MHC class I molecules.
Human natural killer cell receptors for MHC class I molecules have been recently identified by cDNA cloning. They are structurally distinct from murine natural killer cell receptors and can be either inhibitory or stimulatory. Despite structural differences, murine and human receptors are diverse and specific for distinct class I ligands. Their characterization provides insight into natural killer cell functions.
Colonna
M
M
Basel Institute for Immunology, Switzerland. COLONNA@BII.CH
D000818:Animals; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000378:metabolism; D007694:Killer Cells, Natural / Q000737:chemistry* / Q000502:physiology; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000302:isolation & purification*
D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D008024:Ligands; D011956:Receptors, Cell Surface