title: Salivary eicosanoid concentration in patients with Sjögren's syndrome.
abstract: OBJECTIVE
  To investigate eicosanoid concentrations in the saliva of patients with primary Sjögren's syndrome (SS).
  
  
  METHODS
  Whole mixed saliva of 36 subjects was assayed for eicosanoid concentrations using a radioimmunoassay. Patients with primary SS having positive lip biopsy served as the study group; their results were compared with data from patients with dry mouth and negative lip biopsy (dry mouth group), and with a group of normal healthy controls.
  
  
  RESULTS
  Concentrations of thromboxane B2 were significantly (p < 0.01) increased in 18 patients with primary SS compared with 10 patients with dry mouth and eight healthy normal controls (1.95 (SD 0.51) ng/ml saliva compared with 0.52 (0.1) ng/ml and 0.3 (0.1) ng/ml, respectively). Similarly, prostaglandin E2 concentrations were also significantly increased (p < 0.01) in 11 patients with primary SS compared with five patients with dry mouth and eight normal controls (3.75 (0.82) ng/ml saliva compared with 0.32 (0.1) ng/ml and 0.41 (0.1) ng/ml, respectively).
  
  
  CONCLUSIONS
  Salivary concentrations of eicosanoids are significantly increased in patients with primary SS, and this may prove helpful in the diagnosis of this disease.
authors.affiliation: Department of Rheumatology, Ichilov Hospital, Tel Aviv-Sourasky Medical Centre, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Tishler
authors.forename: I
authors.initials: I
authors.lastname: Yaron
authors.forename: A
authors.initials: A
authors.lastname: Raz
authors.forename: F A
authors.initials: FA
authors.lastname: Meyer
authors.forename: M
authors.initials: M
authors.lastname: Yaron
mesh_terms: D015415:Biomarkers / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D015777:Eicosanoids / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism; D011863:Radioimmunoassay; D012463:Saliva / Q000737:chemistry*; D012859:Sjogren's Syndrome / Q000378:metabolism*; D013929:Thromboxane B2 / Q000032:analysis
chemical_list: D015415:Biomarkers; D015777:Eicosanoids; D013929:Thromboxane B2; D015232:Dinoprostone