Proliferative cell senescence, transformation, and the recombination potential of the genome.
Fibroblast cell populations maintained in vitro display a different probability of escaping proliferative senescence and to transform. Observations at the cytogenetic level suggest that the long-term doubling potential of these cells is directly related to the potential for continuous chromosome rearrangements.
Macieira-Coelho
A
A
INSERM, Versailles, France.
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence; D006801:Humans; D011995:Recombination, Genetic