The effects of "huoxuequyu" decoction on lipid peroxidation in IUGR rats.
The rats exposed to passive smoking were used as the animal model to further study the pathogenesis of IUGR and the effects of "Huoxuequyu" decoction. The results showed that the mean birth-weight of fetus and SOD activity of placenta and plasma in model rats were significantly reduced, and LPO levels of placenta and plasma were significantly increased. We found that the mean birth-weight and SOD activity in treated group were higher than that in model group, and LPO levels of placenta and plasma were lower in treated group than that in model group and there was no difference in SOD activity and LPO levels of placenta and plasma as well as the mean birthweight between treated group and control group, indicating that "Huoxuequyu" decoction can protect placenta and plasma against lipid peroxidation, and improve the blood circulation of uteroplacenta, thus contributing to the increase of the mean birth-weight.
Wang
K F
KF
Institute of Integrated Traditional and Western Medicine, Tongji Hospital, Tongji Medical University, Wuhan.
Han
Q H
QH
Shu
H Y
HY
Ye
W Y
WY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000209:etiology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*; D014028:Tobacco Smoke Pollution
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D014028:Tobacco Smoke Pollution; D008315:Malondialdehyde; D013482:Superoxide Dismutase