Fetal chondral homografts in the repair of articular cartilage defects.
Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell-mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuing of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to the mechanical stability of the graft and to the anatomical site of injury.
Specchia
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N
Istituto di Clinica Ortopedica Universita' Cattolica del Sacro Cuore, Roma, Italy.
Gigante
A
A
Falciglia
F
F
Greco
F
F
D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000196:embryology / Q000637:transplantation*; D002358:Cartilage, Articular / Q000473:pathology / Q000601:surgery*; D005260:Female; D005270:Femur Head / Q000473:pathology / Q000601:surgery; D016332:Fetal Tissue Transplantation / Q000379:methods; D006085:Graft Survival; D006614:Hindlimb / Q000473:pathology / Q000601:surgery*; D010329:Patella / Q000473:pathology / Q000601:surgery; D011817:Rabbits