title: Zinc acetate and lyophilized aloe barbadensis as vaginal contraceptive.
abstract: Twenty samples of fresh ejaculate, donated by healthy volunteers ranging in age from 20-30 years, were obtained from the Center for Fertility & Cryobiology, University of Missouri, Columbia, Missouri. Average semen volume was 2.49 ml; average sperm motility was 71.32%; and average sperm density was 113.71 x 10(6) /ml. Testing for spermicidal effectiveness of a 1% concentration of zinc acetate, zinc sulfate, zinc chloride, and zinc gluconate proved that only zinc acetate was spermicidal. It appears this is due to the acetate in zinc acetate which may decrease oxygen utilization by sperm. Zinc acetate in vitro was antiviral while lyophilized aloe barbadensis was not. Lyophilized aloe barbadensis at concentrations of 7.5% and 10% proved to be spermicidal due to the multiple micro elements (boron, barium, calcium, chromium, copper, iron, potassium, magnesium, manganese, phosphorus, and zinc) which were toxic to the tail causing instant immobilization. The two compounds did not irritate or cause ulceration of rabbit vaginal epithelium. These results suggest the possibility of using zinc acetate and lyophilized aloe barbadensis as a new, effective and safe vaginal contraceptive.
authors.affiliation: Center of Reproductive Science and Technology, School of Medicine, University of Missouri, Columbia 65212, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Fahim
authors.forename: M
authors.initials: M
authors.lastname: Wang
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D019342:Acetic Acid; D000176:Acrosin / Q000187:drug effects; D000282:Administration, Intravaginal; D000328:Adult; D000504:Aloe / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002241:Carbohydrates / Q000032:analysis; D005260:Female; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008903:Minerals / Q000032:analysis; D010946:Plants, Medicinal; D011817:Rabbits; D013089:Spermatocidal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects / Q000648:ultrastructure; D014621:Vagina / Q000187:drug effects
chemical_list: D000085:Acetates; D000998:Antiviral Agents; D002241:Carbohydrates; D008903:Minerals; D013089:Spermatocidal Agents; D000176:Acrosin; D019342:Acetic Acid