Effects of the cyclooxygenase inhibitor ibuprofen on retinal and choroidal blood flow during hyperoxia in newborn piglets.
OBJECTIVE
The effect of the cyclooxygenase inhibitor ibuprofen (IB) on choroidal (ChBF) and retinal (RBF) blood flow during hyperoxia was examined in 21 spontaneously breathing newborn piglets.


METHODS
ChBF and RBF were measured using radiolabelled microspheres before and 30 min after either saline or IB (30 mg/kg, i.v.) infusion in room air and subsequently, after 90 min of hyperoxia (O2).


RESULTS
The basal RBF and ChBF did not change after IB infusion. However, during hyperoxia a significant decrease in RBF was observed in the IB group (54 +/- 5 to 37 +/- 3 ml/min/100 g, p < 0.02) and in the control group (54 +/- 3 to 37 +/- 5 ml/min/100 g, p < 0.02). Also, ChBF decreased in the IB group (2,635 +/- 446 to 1,670 +/- 199 ml/min/100 g, p < 0.02) and in the control group, (2,997 +/- 346 to 2,014 +/- 246 ml/min/100 g,p < 0.02) during hyperoxia.


CONCLUSIONS
Despite cyclooxygenase inhibition with IB, RBF and ChBF decreased to the same extent as in the control group following exposure to O2. These data suggest that hyperoxia decrease RBF and ChBF through mechanisms and/or mediators other than the cyclooxygenase by-products of arachidonic acid metabolism.
Stiris
T A
TA
Department of Pediatrics, La Paz Children's Hospital, Spain.
Suguihara
C
C
Flynn
J
J
Quero
J
J
Bancalari
E
E
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002248:Carbon Monoxide / Q000097:blood; D002829:Choroid / Q000098:blood supply* / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology*; D011460:Prostaglandins F / Q000378:metabolism; D012171:Retinal Vessels / Q000187:drug effects*; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014822:Vitreous Body / Q000378:metabolism
D016861:Cyclooxygenase Inhibitors; D011460:Prostaglandins F; D016718:Arachidonic Acid; D002248:Carbon Monoxide; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone; D010100:Oxygen; C100006:prostaglandin F1; D007052:Ibuprofen