A capillary gas-liquid chromatographic method for the assay of the neuroleptic drug zotepine in human serum or plasma.
A capillary gas-liquid chromatographic method suitable for the assay of the atypical neuroleptic drug zotepine in human serum or plasma was developed. A liquid-liquid extraction with three subsequent extraction steps was applied for sample preparation. The minimum detectable concentration was 1.0 ng ml-1. The within-day relative standard deviation (RSD) (n = 6) was 5.3% at 5 ng ml-1, 3.6% at 10 ng ml-1 and 6.1% at 100 ng ml-1. The day-to-day RSD (n = 6) was 9.3% at 10 ng ml-1 and 5.1% at 100 ng ml-1. Steady-state serum levels of four schizophrenic patients were measured.
Ulrich
S
S
Institute of Clinical Pharmacology, University Hospital, Magdeburg, Germany.
Meyer
F P
FP
Bogerts
B
B
D000328:Adult; D014150:Antipsychotic Agents / Q000097:blood* / Q000302:isolation & purification; D001712:Biperiden / Q000097:blood; D002849:Chromatography, Gas; D003988:Dibenzothiepins / Q000097:blood* / Q000302:isolation & purification; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005475:Flupenthixol / Q000097:blood; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000097:blood
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D018727:Muscarinic Antagonists; D001712:Biperiden; D005475:Flupenthixol; C022172:zotepine