title: Trypanocidal value of liposomal diminazene in experimental Trypanosoma brucei evansi infection in mice.
abstract: The trypanocidal value of liposomal diminazene was examined. Three hundred mice were divided randomly into six groups of 50 mice each. Groups 1, 2 and 3 were pretreated 2 h before Trypanosoma brucei evansi challenge with 0.2 ml saline solution, 0.2 ml diminazene solution (5 mg ml-1) and 0.2 ml liposomal solution (5 mg diminazene per ml), respectively. Mice in Group 1 all died within 6 days, 33 in Group 2 and four in Group 3 died within 15 days after challenge, respectively. Groups 4, 5, and 6 were treated 4 days after T. b. evansi challenge with 0.2 ml saline solution 0.2 ml diminazene solution (5 mg ml-1) and 0.2 ml liposomal solution (5 mg diminazene per ml), respectively. Mice in Group 4 all died within 6 days, 19 in Group 5 and two in group 6 died within 15 days after challenge, respectively. The remaining mice survived for more than 30 days, were symptom-free and behaved normally. No adverse effects associated with treatment were noted.
authors.affiliation: Laboratory of Pharmacology, Changchun Veterinary College, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yongsheng
authors.forename: O
authors.initials: O
authors.lastname: Yongchun
authors.forename: R
authors.initials: R
authors.lastname: Chengmai
authors.forename: C
authors.initials: C
authors.lastname: Yuanguo
authors.forename: Z
authors.initials: Z
authors.lastname: Fenqin
mesh_terms: D000818:Animals; D004133:Diminazene / Q000008:administration & dosage / Q000627:therapeutic use*; D004337:Drug Carriers; D006168:Guinea Pigs; D008081:Liposomes; D051379:Mice; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei / Q000302:isolation & purification; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000662:veterinary
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D014344:Trypanocidal Agents; D004133:Diminazene