Induction of SPI-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia.
We cloned genes the expression of which is induced in the Mongolian gerbil (Meriones unguiculatus) hippocampus after transient forebrain ischemia by a differential display technique. Among these genes, a rat serine protease inhibitor SPI-3 homologue was isolated. Present analyses suggested that the expression of gerbil SPI-3 mRNA was closely associated with delayed neuronal death and may block activities of proteases leaking from degenerating neurons or may support neuronal survival.
Tsuda
M
M
Department of Molecular Neurobiology Tanabe, Osaka University Medical School, Japan.
Kitagawa
K
K
Imaizumi
K
K
Wanaka
A
A
Tohyama
M
M
Takagi
T
T
D000595:Amino Acid Sequence; D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017386:Sequence Homology, Amino Acid; D015842:Serine Proteinase Inhibitors / Q000096:biosynthesis*; D013997:Time Factors; D014158:Transcription, Genetic
D015347:RNA Probes; D012333:RNA, Messenger; D015842:Serine Proteinase Inhibitors