Faecal calprotectin shedding after short-term treatment with non-steroidal anti-inflammatory drugs.
BACKGROUND
Increased faecal calprotectin shedding indicates gastrointestinal mucosal inflammation.


METHODS
We studied the effect of short-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) on faecal calprotectin shedding in two randomized crossover studies, with treatment regimens of indomethacin or naproxen for 14 days in the first study (n = 16) and lornoxicam or naproxen for 7 days in the second study (n = 18).


RESULTS
The method's reproducibility and stability were satisfactory. Indomethacin and naproxen increased the faecal calprotectin significantly from a base line of 4.7 mg/l to 9.0 mg/l and 8.0 mg/l, respectively. Lornoxicam failed to increase the faecal calprotectin. Shedding after 7 days of naproxen treatment was positively correlated to gastroduodenal mucosal inflammation assessed by endoscopy.


CONCLUSIONS
Although seemingly influenced by concurrent upper airway infections, the study indicates that the calprotectin test may be useful for monitoring the inflammatory response to NSAID treatment, even in short-term setting.
Meling
T R
TR
Dept. of Gastroenterology, Ullevål Hospital, Oslo, Norway.
Aabakken
L
L
Røseth
A
A
Osnes
M
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D018592:Cross-Over Studies; D005243:Feces / Q000737:chemistry*; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D007249:Inflammation / Q000139:chemically induced; D007413:Intestinal Mucosa / Q000473:pathology; D039841:Leukocyte L1 Antigen Complex; D008297:Male; D009288:Naproxen / Q000009:adverse effects; D019006:Neural Cell Adhesion Molecules / Q000032:analysis*; D010894:Piroxicam / Q000009:adverse effects / Q000031:analogs & derivatives; D015203:Reproducibility of Results
D000894:Anti-Inflammatory Agents, Non-Steroidal; D039841:Leukocyte L1 Antigen Complex; D019006:Neural Cell Adhesion Molecules; D010894:Piroxicam; D009288:Naproxen; C059451:lornoxicam; D007213:Indomethacin