Induced termination of fibrillation.
A previous communication in the Creative Musings section of this Journal summarized additions to the wavelet hypothesis related to the initiation of cardiac fibrillation. That hypothesis is also relevant to the termination of fibrillation, and further additions related to that event are presented in this report. Findings in both reports were obtained with a computer model based on the wavelet hypothesis, and results concerning initiation and termination of fibrillation were closely related. Refractory period (RP) conditions that terminated fibrillation were the inverse of those that increased vulnerability to the initiation of fibrillation. Increased RP range or decreased RP duration increased vulnerability to the initiation of fibrillation and decreased RP range or increased RP duration were capable of terminating fibrillation. Slow propagation increased vulnerability to initiation of fibrillation and acted to sustain fibrillation when instituted during fibrillation. The combination of increased duration and decreased range of RPs was more effective in terminating fibrillation than either alone. The magnitude of increased RP duration or decreased RP range required to terminate fibrillation and the effects of slow propagation on the maintenance of fibrillation depended on RP duration and range present during fibrillation. The findings extend the wavelet hypothesis of the nature of fibrillation to the prediction of conditions required to terminate fibrillation.
Abildskov
J A
JA
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, USA.
D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology*; D003198:Computer Simulation; D006801:Humans; D012032:Refractory Period, Electrophysiological; D014693:Ventricular Fibrillation / Q000209:etiology / Q000503:physiopathology*