[The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity].
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine. Intracutaneous administration of both peptides (300 micrograms/kg) was found to result in weakening perception of stress situations; an increase in stability of investigation behavior and normalization of serotonin level in the brain of rats with chronic deprivation of serotoninergic system activity. Anxiolytic and psychostimulant activities of TP-7 are more pronounced than those of tafcine.
Seredenin
S B
SB
Semenova
T P
TP
Kozlovskaia
M M
MM
Medvinskaia
N I
NI
Nezovibat'ko
V N
VN
D015116:5,7-Dihydroxytryptamine; D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents; D013997:Time Factors; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D014405:Tuftsin; C100827:TP 7
Osobennosti anksioliticheskogo deĭstviia taftsina i ego analoga TP-7 na povedenie i obmen serotonina v mozge krys s khronicheskoĭ deprivatsieĭ aktivnosti serotoninergicheskoĭ sistemy.