[The participation of serotonin S1A and S2 receptors in the formation of different levels of anxiety in male mice under the influence of the experience of social victories and defeats].
Influence of repeated experience of victories or defeats in daily social confrontations on formation of different levels of anxiety was studied in male mice (winners and losers). Repeated experience of defeats in losers produced the pronounced anxiety evaluated in the plus-maze and in the partition test (by the low-expressed behavioural reaction to another conspecific). Flezinoxan (0.5 mg/kg, i. p. 30 min), 5-HT1A receptor agonist, produced changes in the partition test behaviour in winners and controls and was not effective in losers. Ritanserin (2.0 mg/kg, i. p. 30 min), 5-HT2 receptor antagonist, decreased reactivity to a conspecific in losers and winners and was not effective in control. It has been supposed that development of pronounced anxiety in losers is accompanied by a decrease in 5-HT1A receptor sensitivity.
Kudriavtseva
N N
NN
Lipina
T V
TV
Vishnivetskaia
G B
GB
Avgustinovich
D F
DF
D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D003220:Conflict, Psychological; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D010879:Piperazines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D018709:Statistics, Nonparametric
D010879:Piperazines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D016713:Ritanserin; C056895:flesinoxan
Uchastie S1A i S2 retseptorov serotonina v formirovanii razlichnogo urovnia trevozhnosti u samtsov mysheĭ pod vliianiem opyta sotsial'nykh pobed i porazheniĭ.