Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats.
The anticonvulsant effect of 1-naphthylacetyl spermine (1-NA-Spm), an analogue of Joro spider toxin, against amygdaloid kindled seizures was studied in rats. 1-NA-Spm (10, 20 and 40 micrograms/rat) dose-dependently improved kindled seizures and shortened the afterdischarge duration 30 min after the administration. The anticonvulsant effect was observed even one day after the drug, and then gradually disappeared within 4 days. The present findings demonstrate that 1-NA-Spm acts as a potent and long-acting anticonvulsant against amygdaloid kindled seizures, and also suggest, together with the previous findings, that the calcium-permeable AMPA receptors, which are selectively antagonized by 1-NA-Spm, play a critical role in the seizure generation mechanism of amygdaloid kindling.
Takazawa
A
A
Department of Neuropsychiatry, Saitama Medical School, Japan.
Yamazaki
O
O
Kanai
H
H
Ishida
N
N
Kato
N
N
Yamauchi
T
T
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007696:Kindling, Neurologic; D008297:Male; D009498:Neurotoxins; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D013096:Spermine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013111:Spider Venoms
D000925:Anticoagulants; D018691:Excitatory Amino Acid Antagonists; C044936:JSTX spider toxin; D009498:Neurotoxins; D011810:Quinoxalines; D018091:Receptors, AMPA; D013111:Spider Venoms; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; C067506:1-naphthylacetylspermine; D013096:Spermine