title: Model building of antibody combining sites.
abstract: The number of high quality crystal structures of antibody fragments available in the Brookhaven Protein Data Bank is rapidly increasing. These structures provide a substantial knowledge base and support model building of novel antibody combining sites. We review some basic principles of antibody structure, describe structure-based modelling procedures, and indicate the strengths and weaknesses of the modelling approach. Applications of antibody models are discussed.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bajorath
authors.forename: J
authors.initials: J
authors.lastname: Novotny
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D001666:Binding Sites, Antibody; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D000906:Antibodies