title: Histologic evidence of absorption of sequestration-type herniated disc.
abstract: METHODS
  The reactions to sequestrated disc fragments, which were removed surgically from 35 patients, were examined histologically.
  
  
  OBJECTIVE
  To elucidate whether or not there is histologic evidence of absorption of sequestrated discs.
  
  
  BACKGROUND
  Spontaneous disappearance or diminution of lumbar herniated discs in the spinal canal has been recognized, and this could be a possible explanation for relief of symptoms without surgery. The mechanism of this phenomenon is unclear.
  
  
  METHODS
  Sequestrated discs removed surgically from 35 patients were examined histologically.
  
  
  RESULTS
  In 30 cases, neovascularization was observed at the periphery of the sequestrated discs. Many foamy cells (macrophages) were present in the vascularized areas. In addition, immunohistochemistry revealed that many spindle-shaped, fibroblast-like cells were positive for CD68, a marker of macrophages. No fibrous scar formation was observed in any region.
  
  
  CONCLUSIONS
  These findings suggest that organization is not a main course for this type of herniated disc and that a kind of "absorption" process occurs predominantly in the healing stage.
authors.affiliation: Department of Pathology, Brain Research Institute, Niigata University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: F
authors.initials: F
authors.lastname: Ikuta
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: S I
authors.initials: SI
authors.lastname: Hoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaji
authors.forename: S
authors.initials: S
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Homma
authors.forename: H E
authors.initials: HE
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005260:Female; D005487:Foam Cells / Q000276:immunology / Q000473:pathology; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000473:pathology*; D008159:Lumbar Vertebrae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology; D012075:Remission, Spontaneous; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule