Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas.
The methylation status of Myf-3 was studied in 34 human primary breast carcinomas and 9 normal breast tissues. One third of the carcinomas contained hypermethylated Myf-3. All normal tissues contained unmethylated Myf-3. Myf-3 hypermethylation was more common in poorly differentiated grade 3 tumours than in better differentiated grade 1 and 2 tumours.
Hähnel
R
R
Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Australia.
Harvey
J
J
Kay
P
P
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D001483:Base Sequence; D001940:Breast / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008745:Methylation; D017570:MyoD Protein / Q000235:genetics*; D009361:Neoplasm Invasiveness; D011003:Ploidies; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012016:Reference Values; D015183:Restriction Mapping; D016196:S Phase; D015534:Trans-Activators / Q000235:genetics
D004273:DNA, Neoplasm; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015534:Trans-Activators