Effect of aluminum on hematopoiesis after intraperitoneal exposure in rats.
The experiments were performed on female Wistar rats that received aluminum chloride every day intraperitoneally, 4 mg Al/kg for 3 weeks. In the blood selected morphological factors and delta-aminolevulinic acid dehydratase activity (ALA-D) were investigated. In the kidney and liver ALA-D, delta-aminolevulinic acid synthase (ALA-S), and heme oxygenase activity were also determined. After aluminum chloride administration the most sensitive indicator was an increase of heme oxygenase activity in the liver and a decrease in iron levels in the serum of rats. Aluminum also increased ALA-S activity in the kidney and liver of rats. No changes of ALA-D activity in the liver, the kidney, and the blood were observed. The decreasing of hemoglobin, hematocrit, mean corpuscular hemoglobin mass, and mean corpuscular hemoglobin concentration was noted after 3 weeks of exposure.
Chmielnicka
J
J
Department of Toxicological Chemistry, Medical University of Lódź, Poland.
Nasiadek
M
M
Lewandowska-Zyndul
E
E
Pińkowski
R
R
D000624:5-Aminolevulinate Synthetase / Q000097:blood / Q000378:metabolism; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D001252:Astringents / Q000008:administration & dosage / Q000633:toxicity; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects*; D006419:Heme Oxygenase (Decyclizing) / Q000097:blood / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007501:Iron / Q000097:blood; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D000623:Porphobilinogen Synthase / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D017607:Aluminum Compounds; D001252:Astringents; D002712:Chlorides; D006454:Hemoglobins; D000077410:Aluminum Chloride; D007501:Iron; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase; D000623:Porphobilinogen Synthase