title: Allergic urticaria and angioedema caused by a hemostatic sponge of bovine fibrin used in tooth extraction.
abstract: We report the case of a 54-year-old woman with no history of atopic diseases or drug allergies who developed a generalized anaphylactic reaction with urticaria and angioedema a few hours after tooth extraction. The skin scratch and RAST tests demonstrated IgE-mediated hypersensitivity to the product Hémofibrine, a hemostatic sponge made of bovine fibrin. Of all RAST controls, only one serum with known positivity to bovine serum albumin (BSA) showed a low degree of positivity to Hémofibrine. Bovine fibrin should be added to the list of medical products that can elicit allergic reactions following dental treatment.
authors.affiliation: Department of Dermatology, University Hospital, Zurich, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Wüthrich
authors.forename: E
authors.initials: E
authors.lastname: Bianchi-Kusch
authors.forename: S G
authors.initials: SG
authors.lastname: Johansson
mesh_terms: D000707:Anaphylaxis / Q000276:immunology*; D000799:Angioedema / Q000276:immunology*; D005260:Female; D005339:Fibrin Foam / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012882:Skin Tests; D014014:Tissue Adhesives; D014081:Tooth Extraction / Q000009:adverse effects; D014581:Urticaria / Q000276:immunology*
chemical_list: D005339:Fibrin Foam; D014014:Tissue Adhesives; D007073:Immunoglobulin E