[Effect of a 17 beta estradiol gel preparation on hormone levels in menopausal women].
Different delivery forms of supplemental estrogens may differ in their hormonal effects. The aim of this study was to assess the effects of a daily dose of 2.5 g of 17 beta estradiol transdermal gel, given during four weeks, on hormone levels of six postmenopausal women. At the fourth week we observed a significant increase in estradiol and a decrease in FSH levels. Estrone levels also increased but the estradiol/estrone ratio was maintained in values over 1. No changes in SHBG or IGF1 levels were observed. Two patients that used the gel in the abdominal skin achieved lower estradiol levels (below 60 pg/ml). We conclude that the gel increased serum estradiol levels over 60 pg/ml in four of six women, that there is a big individual variability and the application zone could influence the serum estradiol levels achieved.
Araya
V
V
Sección Endocrinología, Hospital Clínico de la Universidad de Chile, Santiago.
Contreras
P
P
Aguirre
C
C
Foradori
A
A
D000279:Administration, Cutaneous; D002677:Chile; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D004970:Estrone / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005782:Gels; D006801:Humans; D015592:Immunoradiometric Assay; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D011863:Radioimmunoassay; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D005782:Gels; D012738:Sex Hormone-Binding Globulin; D004970:Estrone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D005640:Follicle Stimulating Hormone
Efecto de un preparado en forma de gel de 17 beta estradiol sobre diferentes parámetros hormonales en mujeres menopáusicas.