Indole and (E)-2-hexenal, phytochemical potentiators of polymyxins against Pseudomonas aeruginosa and Escherichia coli.
Combinations of polymyxins and phytochemicals were tested for antimicrobial activity against two gram-negative bacteria. Various degrees of potentiation were found against Pseudomonas aeruginosa and Escherichia coli with (E)-2-hexenal and indole. Three-compound combinations were found to further increase the activity of polymyxin B sulfate and colistin methanesulfonate against both bacteria. Combinations with colistin against P. aeruginosa resulted in the highest degree of potentiation, with a 512-fold increase in colistin antimicrobial activity. These results indicate the potential efficacy of phytochemical combinations with antibiotics to enhance total biological activity.
Kubo
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Department of Environmental Science, Policy and Management, University of California, Berkeley 94720-3112, USA.
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Kubo
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects*; D018757:GABA Modulators / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D018757:GABA Modulators; D007211:Indoles; C030374:indole; D006591:Hexobarbital; D011112:Polymyxin B; D003091:Colistin