Effect of radiotherapy on serum level of interleukin 6 in patients with cervical carcinoma.
To determine the inflammatory state of cervical cancer after radiotherapy, we examined serum interleukin 6 levels (sIL-6) and C-reactive protein (CRP) before and after radiation therapy in sixteen patients with cervical cancer. External radiation therapy did not cause changes in sIL-6 and CRP during the examined periods. On the other hand, brachytherapy caused transient elevation of sIL-6 on the day after treatment by 6.39 +/- 1.89 pg/ml to 13.41 +/- 2.34 pg/ml (p < 0.05) while CRP did not show any significant change. Therefore, brachytherapy would induce a small inflammatory reaction. However, we confirmed that radiotherapy is a less invasive treatment than surgery from the point of view of cytokine related inflammation.
Tang
J T
JT
Department of Radiation Oncology, Osaka University Medical School, Japan.
Yamazaki
H
H
Nishimoto
N
N
Inoue
T
T
Nose
T
T
Koizumi
M
M
Tanaka
E
E
Ogata
A
A
Yoshizaki
K
K
Inoue
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000528:radiation effects; D008875:Middle Aged; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000276:immunology / Q000532:radiotherapy*
D015850:Interleukin-6; D002097:C-Reactive Protein