Epstein-Barr virus and the B cell: that's all it takes.
Recent experiments demonstrate that a much broader range of B cells harbor Epstein-Barr virus (EBV) in vivo than was previously expected from in vitro studies. In this review it is argued that EBV persists in vivo by integrating its biology with that of the normal B cells within which it resides, and that the B cell provides all the environments necessary for EBV to maintain its life cycle.
Thorley-Lawson
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DA
Dept of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA. dlawson@opal.tufts.edu
Miyashita
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EM
Khan
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D000956:Antigens, Viral / Q000502:physiology; D001402:B-Lymphocytes / Q000821:virology*; D004268:DNA-Binding Proteins / Q000502:physiology; D019309:Epstein-Barr Virus Nuclear Antigens; D006566:Herpesviridae Infections / Q000821:virology; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D014412:Tumor Virus Infections / Q000821:virology; D017735:Virus Latency / Q000502:physiology*
D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens