title: Anthelmintic activity of papaya latex against patent Heligmosomoides polygyrus infections in mice.
abstract: The purpose of this experiment was to study the possible anthelmintic activity of papaya latex (Carica papaya) against Heligmosomoides polygyrus in experimentally infected mice. Five groups of BALB/C mice were infected with 100 Heligmosomoides polygyrus infective larvae/mouse. After patency (day 22) four groups of mice (groups B, C, D and E) were given papaya latex suspended in water at dose levels of 2, 4, 6 and 8 g of papaya latex/kg body weight, respectively. One group of mice (group A) served as non-treated controls. All animals were necropsied on day 25, i.e. 3 days after treatment, for post-mortem worm counts. The papaya latex showed an antiparasitic efficacy of 55.5, 60.3, 67.9 and 84.5% in groups B, C, D and E, respectively. The results may suggest a potential role of papaya latex as an anthelmintic against patent intestinal nematodes of mammalian hosts.
authors.affiliation: Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
authors.forename: F
authors.initials: F
authors.lastname: Satrija
authors.forename: P
authors.initials: P
authors.lastname: Nansen
authors.forename: S
authors.initials: S
authors.lastname: Murtini
authors.forename: S
authors.initials: S
authors.lastname: He
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005638:Fruit; D007840:Latex / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D009351:Nematospiroides dubius; D010946:Plants, Medicinal; D017206:Strongylida Infections / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D007840:Latex