Involvement of delta-opioid receptors in immunosuppression.
The present experiments demonstrate that: (1) activation of delta-opioid receptors by a highly selective agonist DSLET leads to immunosuppression, whereas the blockade of these receptors by enkephalin analog ICI 174864 produces immunostimulation; (2) the immunomodulating effect of delta-opioid receptors is mediated by central mechanisms involving the hypothalamus-hypophysis complex; (3) the postsynaptic 5-HT (serotonin) receptors of 5-HT-2 type are involved in the immunoinhibitory action of DSLET. On the other hand, the immunostimulating effect of ICI 174864 is realized with the participation of D-2 postsynaptic DA (dopamine) receptors. It has also been shown that thymus is implicated in the immunostimulating influence of ICI 174864. The data obtained are explained as a result of the interaction of the neuromediator and opioid peptidergic systems in neuroimmunomodulation.
Cheido
M
M
Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation.
Idova
G
G
Devoino
L
L
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology; D007075:Immunoglobulin M / Q000276:immunology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010902:Pituitary Gland / Q000502:physiology; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012397:Rosette Formation; D018490:Serotonin Agents / Q000494:pharmacology; D013950:Thymus Gland / Q000502:physiology; D010948:Viral Plaque Assay
D000700:Analgesics; D015259:Dopamine Agents; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D017465:Receptors, Opioid, delta; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D004743:Enkephalin, Leucine; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-