title: Spinal tuberculosis with neurological deficits.
abstract: Two hundred patients suffering from tuberculosis (TB) of the spine with neurological complications were the subjects of this review. They were graded according to the Frankel system into--A: complete neurological deficit; B: sparing of some sensation; C: sparing of sensation but no useful motor function; D: sparing of sensation and useful motor function; and E: no deficits. Investigations carried out included detailed neurological assessment, radiography, contrast myelography and, in the later stages of the study, spinal computerized tomography (CT) scan. The authors believe that contrast myelography provides the best indication of spinal compression in TB spine. Treatment was by surgical decompression followed by chemotherapy. The surgical approach for thoracic spine disease was by the anterior transthoracic route. Cervical lesions were also approached by the anterior route, lateral to the carotid vessels. Unexpected findings during operation included lymphoma, plasmacytoma, non-tuberculous granulation tissue, salmonella osteomyelitis and tumour metastasis. Ten patients died during the postoperative period, all of whom had extensive systemic TB. When indicated, antituberculous drugs were administered postoperatively for two years and immobilization was done in a plaster cast for 3 months. Only 30 patients showed partial recovery. Improvement was found to be related to the grade of deficit; thoracic lesions with severe neurological deficits showed the least improvement while lumbar disease had the best outcome. The study recommended a combination of surgery and chemotherapy for all cases of TB spine with neurological deficits after a short delay during which respiratory function should be improved. The surgery should aim at decompression of the cord by removal of pus, granulation tissue and sequestra, with internal splintage with bone grafts to reduce the hospital stay. Conservative treatment is unwise because it is not always possible to distinguish between TB and neoplastic lesions.
authors.affiliation: Department of Neurosurgery, Sanjay Gandhi Accident and Rehabilitation Centre, Bangalore, Karnataka.
authors.forename: C
authors.initials: C
authors.lastname: Vidyasagar
authors.forename: H K
authors.initials: HK
authors.lastname: Murthy
mesh_terms: D005260:Female; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008297:Male; D010264:Paraplegia / Q000209:etiology; D013117:Spinal Cord Compression / Q000209:etiology; D014399:Tuberculosis, Spinal / Q000150:complications* / Q000453:epidemiology / Q000628:therapy