cDNAs from Onchocerca sp. encoding members of the MRS3/MRS4 class of mitochondrial solute carriers.
cDNA clones from the parasitic nematodes Onchocerca volvulus and Onchocerca gibsoni encode homologs of the yeast proteins MRS3 and MRS4. Together with an uncharacterised ORF on chromosome III of Caenorhabditis elegans, these constitute a new class of proteins belonging to the mitochondrial solute carrier protein superfamily. So far, five other members of this protein family have been identified in C. elegans, but levels of identity between these and the Onchocerca proteins were considerably lower. Consideration of cysteine content and overall charge implies that the natural substrates of the nematode proteins are small ions.
Catmull
J
J
Department of Biochemistry and Molecular Biology, James Cook University of North Queensland, Townsville, Australia.
Miller
D J
DJ
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics*; D027682:Cation Transport Proteins; D002462:Cell Membrane / Q000737:chemistry; D003545:Cysteine / Q000032:analysis; D003600:Cytosol / Q000737:chemistry; D018076:DNA, Complementary / Q000737:chemistry*; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D009854:Onchocerca / Q000235:genetics*; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D016415:Sequence Alignment
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D018076:DNA, Complementary; D005656:Fungal Proteins; C066985:MRS3 protein, S cerevisiae; C066986:MRS4 protein, S cerevisiae; D024101:Mitochondrial Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003545:Cysteine