[The role of complement in inhibition of intracellular bactericidal activity to P. aeruginosa of PMN in seriously burnt patients].
129 PMN-samples from the peripheral blood of 70 burnt patients were collected, and ICBA, SG and O2- were dynamically studied. The harmful effects on patients' plasma on normal human PMN, and specific blocking effect of anti-human C3. C5 serum (AHC3C5S) on the above harmful effects were also observed.


RESULTS
1) All the parameters values showed a significant decrease in seriously or moderately burnt patients as compared with normal values; the decrease was most marked on 1st-6th postburn days when deep burn surface exceeded 45%. 2) ICBA was significantly correlated with SG and O2-. 3) Patients' plasma greatly reduced the reserves of ICBA, SG and O2- in normal PMN, while AHC3C5S might lessen the reduction in term of net reserve rates: ICBA (67.33) > SG (51.60) > O2- (46.68). The findings suggest: ICBA levels are reversely related with DBSA and fragments of C3 and C5 are the main factors in reduction of ICBA.
Wang
Z
Z
Department of Microbiology, Third Military Medical College, Chongqing.
Zhou
S
S
Xian
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001770:Blood Bactericidal Activity; D002056:Burns / Q000276:immunology / Q000382:microbiology*; D002648:Child; D003165:Complement System Proteins / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011552:Pseudomonas Infections; D011550:Pseudomonas aeruginosa / Q000502:physiology*
D003165:Complement System Proteins