Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents.
Soybean transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean phosphatidylcholine by transphosphatidylation using phospholipase D, and the fatty acids composition and pharmacological properties were compared with those of bovine brain cortex-derived phosphatidylserine (BC-PS) which was reported to improve cognitive disorders of senile dementia patients by oral administration (300 mg/day). The molecular species of SB-tPS are rich in linoleic and palmitic acids whereas those of BC-PS are stearic and oleic acids. Despite the differences in fatty acid composition, SB-tPS displayed significant activities on the increase in brain glucose concentrations in mice (79 mg/kg, i.v.) and the restoration of scopolamine-induced amnesia in rats (60 mg/kg, i.p.) as did BC-PS. These results suggest the possibility that SB-tPS may prevent and/or improve senile dementia by oral administration.
Sakai
M
M
Yakult Central Institute for Microbiological Research, Tokyo, Japan.
Yamatoya
H
H
Kudo
S
S
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001923:Brain Chemistry; D002417:Cattle; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D019301:Oleic Acid; D009829:Oleic Acids / Q000032:analysis; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000378:metabolism*; D010718:Phosphatidylserines / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine; D013025:Glycine max / Q000737:chemistry*; D013229:Stearic Acids / Q000032:analysis
D001786:Blood Glucose; D008041:Linoleic Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D013229:Stearic Acids; D019301:Oleic Acid; D019308:Palmitic Acid; C031183:stearic acid; D019787:Linoleic Acid; D012601:Scopolamine