title: A prognostic score for prostatic adenocarcinoma based on clinical, histological, biochemical and cytometric data from the primary tumour.
abstract: The aim of this study was to create a multivariate prognostic score for prostatic adenocarcinoma. A retrospective analysis of clinical, histological and cytometric prognostic factors in 325 cases of prostatic adenocarcinoma followed up on average over 13 years was performed. A multivariate prognostic score was built by using the independent prognostic factors. M-category, T-category, Gleason score and patient age were independent prognostic factors in the entire cohort. In MO tumors T-category, density of tumor infiltrating lymphocytes, the presence of apoptotic cells, and patient age were independent prognostic factors. In T1-2MO tumors the density of tumour infiltrating lymphocytes, mitotic index, standard deviation of maximum nuclear diameter and the serum level of acidic phosphatase were independent prognostic factors. By combining the coefficients of the regression model, a prognostic score was built for each of the tumour categories. The subsequent survival analysis based on the prognostic score indicated that it is a highly significant prognostic factor superior to individual prognostic parameters. The results show that the combination of prognostic data is a valuable tool in assessing the correct prognostic category for prostatic adenocarcinoma.
authors.affiliation: Department of Pathology, University of Kuopio, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Lipponen
authors.forename: S
authors.initials: S
authors.lastname: Vesalainen
authors.forename: J
authors.initials: J
authors.lastname: Kasurinen
authors.forename: M
authors.initials: M
authors.lastname: Ala-Opas
authors.forename: K
authors.initials: K
authors.lastname: Syrjänen
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D002453:Cell Cycle; D004796:Clinical Enzyme Tests; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D004273:DNA, Neoplasm; D005500:Follow-Up Studies; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate
chemical_list: D004273:DNA, Neoplasm; D003404:Creatinine