title: Transcriptional expression of Epstein-Barr virus genes and proto-oncogenes in north African nasopharyngeal carcinoma.
abstract: Cases of nasopharyngeal carcinoma (NPC) from North Africa show an unusual bimodal age distribution. As elsewhere, the tumor is closely associated with the presence of Epstein-Barr virus (EBV). The expression of EBV genes and c-onc genes was studied in biopsy specimens from tumors at different clinical stages from 11 young (10 to 30-year-old) and 11 adult (30 to 65-year-old) patients. It was found that the two age groups do not differ in their pattern of gene expression, that there is a tendency for later stage biopsies to express more viral and c-onc transcripts, and that samples expressing larger numbers of EBV genes also tend to express many different c-onc specificities.
authors.affiliation: Laboratoire de Virologie Moléculaire, CNRS, Faculté de Médecine Alexis Carrel, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Sbih-Lammali
authors.forename: D
authors.initials: D
authors.lastname: Djennaoui
authors.forename: H
authors.initials: H
authors.lastname: Belaoui
authors.forename: A
authors.initials: A
authors.lastname: Bouguermouh
authors.forename: G
authors.initials: G
authors.lastname: Decaussin
authors.forename: T
authors.initials: T
authors.lastname: Ooka
mesh_terms: D000293:Adolescent; D000328:Adult; D000352:Africa, Northern; D000368:Aged; D000375:Aging; D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000821:virology*; D002460:Cell Line; D002648:Child; D018628:Gene Dosage; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000821:virology*; D011519:Proto-Oncogenes; D014158:Transcription, Genetic