The neurotrophin NT4/5, but not NT3, enhances the efficacy of nigral grafts in a rat model of Parkinson's disease.
The neurotrophins NT4/5 and NT3 have previously been shown to improve the survival and fibre outgrowth of embryonic dopaminergic neurons in vitro. In the present study we attempted to augment the efficacy of embryonic nigral grafts in vivo. This was done by directly infusing the neurotrophins intraparenchymally in close proximity to transplanted nigral tissue placed in the dopamine depleted striatum of 6-hydroxydopamine lesioned rats. Our results indicated that NT4/5, but not NT3, stimulated fibre growth from embryonic nigral cells and enhanced functional efficacy of the grafts as assessed by metamphetamine-induced rotation.
Haque
N S
NS
MRC Cambridge Centre for Brain Repair, UK.
Hlavin
M L
ML
Fawcett
J W
JW
Dunnett
S B
SB
D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D016332:Fetal Tissue Transplantation; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000494:pharmacology*; D020933:Neurotrophin 3; D010302:Parkinson Disease, Secondary / Q000601:surgery*; D010865:Pilot Projects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012399:Rotation; D013378:Substantia Nigra / Q000187:drug effects / Q000196:embryology / Q000637:transplantation*; D016896:Treatment Outcome
D009414:Nerve Growth Factors; D020933:Neurotrophin 3