Fatal cerebellar haemorrhage due to phenprocoumon poisoning.
A 32-year-old patient died of a cerebellar haemorrhage and the blood coagulation analysis before death suggested defective synthesis of vitamin K-dependent clotting factors due to vitamin K deficiency. The post-mortem toxicological examination of different tissues revealed phenprocoumon poisoning as the cause of death. The differential diagnosis of vitamin K deficiency and the toxicology of hydroxycoumarins are discussed.
Höhler
T
T
Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany.
Becker
J
J
Meyer zum Büschenfelde
K H
KH
Rittner
C
C
D000328:Adult; D001780:Blood Coagulation Tests; D001921:Brain / Q000473:pathology; D001926:Brain Death / Q000473:pathology; D002526:Cerebellar Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000473:pathology*; D006801:Humans; D008297:Male; D010644:Phenprocoumon / Q000493:pharmacokinetics / Q000506:poisoning*; D014813:Vitamin K Deficiency / Q000097:blood / Q000150:complications / Q000473:pathology
D010644:Phenprocoumon