Evaluation of a new solution containing trehalose for twenty-hour canine lung preservation.
We examined the efficacy of two new preservation solutions containing trehalose--an extracellular type (ET-K) of solution and an intracellular type (IT-K) of solution--in relation to that of Euro-Collins (EC) solution in 20-h canine lung preservation. Canine lungs were flushed with one of the three solutions (n = 5 for each solution) after pretreatment with PGE1 (20 micrograms/kg) and were stored for 20 h at 4 degrees C. The left lungs were transplanted and evaluated to 6 h post transplant. In the ET-K group, the arterial oxygen tension after reperfusion was significantly higher than in the IT-K and EC groups. The pulmonary vascular resistance, wet/dry weight ratio, and histological evaluation of each transplanted lung in the ET-K group were also better than in the IT-K and EC groups. This indicates that ET-K solution is useful for 20-h preservation of canine lung grafts.
Kajiwara
N
N
Department of Surgery, Tokyo Medical College, Japan.
Taguchi
M
M
Saito
H
H
Nakajima
S
S
Hayashi
A
A
Kawate
N
N
Konaka
C
C
Wada
H
H
Kato
H
H
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D006982:Hypertonic Solutions; D007511:Ischemia; D008168:Lung; D016040:Lung Transplantation / Q000473:pathology / Q000502:physiology*; D009926:Organ Preservation; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011651:Pulmonary Artery; D011654:Pulmonary Edema; D012996:Solutions; D013997:Time Factors; D014199:Trehalose
C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D012996:Solutions; D014199:Trehalose; D010100:Oxygen