title: Lung hypoplasia and surfactant system immaturity induced in the fetal rat by prenatal exposure to nitrofen.
abstract: We studied the biochemical maturity of the lungs of fetuses born to rats exposed to nitrofen on day 9.5 of gestation. In comparison with controls, nitrofen-treated fetuses had pulmonary hypoplasia (decreased lung/body weight), lung hypocellularity (low DNA content) and cellular atrophy (low protein/DNA and phospholipid/DNA) on gestational days 19 and 21. Treated animals with congenital diaphragmatic hernia (CDH) also had cell atrophy and surfactant immaturity (decreased disaturated phosphatidylcholine/DNA) near term. Our data demonstrate that nitrofen causes lung hypoplasia and some degree of surfactant system immaturity that is particularly prominent in fetuses with CDH.
authors.affiliation: Department of Pediatrics, Hospital of Cruces, Basque University School of Medicine, Billbao, Spain.
authors.forename: L F
authors.initials: LF
authors.lastname: Alfanso
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez
authors.forename: B
authors.initials: B
authors.lastname: Qi
authors.forename: J A
authors.initials: JA
authors.lastname: Diez-Pardo
authors.forename: A
authors.initials: A
authors.lastname: Vallis-i-Soler
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
mesh_terms: D000818:Animals; D005260:Female; D065630:Hernias, Diaphragmatic, Congenital; D008168:Lung / Q000002:abnormalities / Q000187:drug effects* / Q000196:embryology; D008297:Male; D010647:Phenyl Ethers / Q000633:toxicity*; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010647:Phenyl Ethers; D010713:Phosphatidylcholines; D010743:Phospholipids; D011663:Pulmonary Surfactants; C017463:lecithins, disaturated; C007350:nitrofen