The role of hemolymph coagulation in innate immunity.
Invertebrate animals, which lack adaptive immune systems, have developed defense systems that respond to common antigens on the surface of potential pathogens. Hemolymph coagulation is one such defense system in innate immunity. The discovery of lipopolysaccharide-sensitive and (1-->3)-beta-D-glucan-sensitive serine protease zymogens in horseshoe crab (limulus) hemocytes, both of which trigger the coagulation cascade, has exemplified how the animals detect and respond to foreign materials.
Muta
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Department of Biology, Kyushu University, Fukuoka, Japan.
Iwanaga
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D000595:Amino Acid Sequence; D000818:Animals; D001777:Blood Coagulation / Q000276:immunology* / Q000502:physiology; D001779:Blood Coagulation Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism; D006434:Hemocytes / Q000276:immunology; D006458:Hemolymph / Q000276:immunology* / Q000378:metabolism; D006737:Horseshoe Crabs / Q000737:chemistry / Q000166:cytology / Q000276:immunology; D007113:Immunity, Innate; D007448:Invertebrates / Q000276:immunology*; D008070:Lipopolysaccharides / Q000378:metabolism; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D001779:Blood Coagulation Factors; D001798:Blood Proteins; D008070:Lipopolysaccharides; C013445:coagulogen; C085383:coagulation factor G, horseshoe crab