title: Craniosynostosis suggestive of Saethre-Chotzen syndrome: clinical description of a large kindred and exclusion of candidate regions on 7p.
abstract: We describe the clinical manifestations of an autosomal dominant form of craniosynostosis in a large family with eight affected relatives. Unilateral or bilateral coronal synostosis, low frontal hair line, strabismus, ptosis, and partial cutaneous syndactyly of fingers and toes are findings suggestive of the diagnosis of Saethre-Chotzen syndrome. The disease locus was excluded from the two adjacent Saethre-Chotzen candidate regions on 7p by linkage analysis with markers D7S664 and D7S507. This indicates heterogeneity of Saethre-Chotzen syndrome with a locus outside the candidate regions on 7p.
authors.affiliation: Abteilung für Plastische Chirurgie, Städtisches Krankenhaus Bogenhausen, München, Germany.
authors.forename: S
authors.initials: S
authors.lastname: von Gernet
authors.forename: S
authors.initials: S
authors.lastname: Schuffenhauer
authors.forename: A
authors.initials: A
authors.lastname: Golla
authors.forename: P
authors.initials: P
authors.lastname: Lichtner
authors.forename: S
authors.initials: S
authors.lastname: Balg
authors.forename: W
authors.initials: W
authors.lastname: Mühlbauer
authors.forename: J
authors.initials: J
authors.lastname: Murken
authors.forename: J
authors.initials: J
authors.lastname: Fairley
authors.forename: T
authors.initials: T
authors.lastname: Meitinger
mesh_terms: D000168:Acrocephalosyndactylia / Q000145:classification / Q000235:genetics*; D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003398:Craniosynostoses / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D003937:Diagnosis, Differential; D005145:Face / Q000002:abnormalities; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011859:Radiography; D012886:Skull / Q000002:abnormalities / Q000000981:diagnostic imaging; D012984:Software; D013577:Syndrome
chemical_list: D005819:Genetic Markers