title: DNA double-strand break repair functions defend against parvovirus infection.
abstract: We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Tauer
authors.forename: M H
authors.initials: MH
authors.lastname: Schneiderman
authors.forename: J K
authors.initials: JK
authors.lastname: Vishwanatha
authors.forename: S L
authors.initials: SL
authors.lastname: Rhode
mesh_terms: D000818:Animals; D016466:CHO Cells; D002467:Cell Nucleus / Q000821:virology; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D017992:Parvovirus / Q000472:pathogenicity / Q000502:physiology* / Q000528:radiation effects; D011991:Receptors, Virus / Q000502:physiology / Q000528:radiation effects*; D014779:Virus Replication / Q000528:radiation effects*
chemical_list: D011991:Receptors, Virus