Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar affective disorder.
A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many additional genes with trinucleotide repeats are believed to be expressed in the human brain. As anticipation has been reported in schizophrenia and bipolar affective disorder, we have examined allele distributions of 13 trinucleotide repeat-containing genes, many novel and all expressed in the brain, in genomic DNA from schizophrenic (n = 20-97) and bipolar affective disorder patients (23-30) and controls (n = 43-146). No evidence was obtained to implicate expanded alleles in these 13 genes as causal factors in these diseases.
Jain
S
S
East Anglian Regional Genetics Service Molecular Genetics Laboratory, Addenbrooke's NHS Trust, Cambridge, United Kingdom.
Leggo
J
J
DeLisi
L E
LE
Crow
T J
TJ
Margolis
R L
RL
Li
S H
SH
Goodburn
S
S
Walsh
C
C
Paykel
E S
ES
Ferguson-Smith
M A
MA
Ross
C A
CA
Rubinsztein
D C
DC
D001483:Base Sequence; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D017931:DNA Primers; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*; D018911:Trinucleotide Repeats
D017931:DNA Primers