Genetic algorithms for protein structure prediction.
Genetic algorithms are a general class of search methods that mimic natural gene-based optimization mechanisms. Mutation, cross-over and replication operations are performed on strings. When applied to structure prediction, each string describes a particular conformation of a protein molecule. There are many ways in which such search methods may be implemented. Recent results show potential for helping with protein structure prediction, but more data are needed before a complete assessment can be made.
Pedersen
J T
JT
University of Maryland Biotechnology Institute, Rockville, MD 20850, USA.
Moult
J
J
D000465:Algorithms; D003198:Computer Simulation; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics
D011506:Proteins