Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg.
Subdivision of the limb primordia of Drosophila into anterior and posterior compartments triggers cell interactions that pattern the legs and wings. A comparable compartment-based mechanism is used to pattern the dorsal-ventral axis of the wing. Evidence is presented here for a mechanism based on cell interaction, rather than on compartment formation, that distinguishes dorsal from ventral in the leg. Mutual repression by Wingless and Decapentaplegic signaling systems generates a stable regulatory circuit by which each gene maintains its own expression in a spatially restricted domain. Compartment-independent patterning mechanisms may be used by other organisms during development.
Brook
W J
WJ
European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany.
Cohen
S M
SM
D000818:Animals; D030801:Animals, Genetically Modified; D019070:Cell Lineage; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D029721:Drosophila Proteins; D005121:Extremities / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D007301:Insect Hormones / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D009024:Morphogenesis; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D007301:Insect Hormones; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C064196:dpp protein, Drosophila; C074622:wg protein, Drosophila