APOE alleles in Alzheimer's disease and vascular dementia in a population aged 85+.
Apolipoprotein E genotyping was carried out in a stratified random sample of 52 patients with Alzheimer's disease, 48 patients with vascular or mixed dementia, and 49 nondemented controls in a population-based study of people aged 85 and older (the Vantaa 85+ Study). Our results indicate that the apolipoprotein E epsilon 4 allele is associated with approximately a twofold increase in clinically diagnosed Alzheimer's disease in this very old general population aged 85+. When combined with previous studies, our data also suggest that the association is decreasing with age. In contrast, there appears to be no relation between apolipoprotein E alleles and clinically diagnosed vascular dementia.
Sulkava
R
R
Department of Community Health and General Practice, University of Kuopio, Finland.
Kainulainen
K
K
Verkkoniemi
A
A
Niinistö
L
L
Sobel
E
E
Davanipour
Z
Z
Polvikoski
T
T
Haltia
M
M
Kontula
K
K
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism*; D015140:Dementia, Vascular / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male
D001057:Apolipoproteins E