[Effect of the nature of the heteroatom of a monosaccharide derivative on its inhibitory action in relation to P-type calcium channels expressed in the Xenopus oocyte].
Our results demonstrate that saccharidic derivatives obtained by adding a C8 alkyl group through various heteroatomes (O, N or S) to a monoacetonide residue possess an inhibitory effect towards putative P-type calcium channels expressed in Xenopus oocytes. These derivatives partially and reversibly inhibit the activity these channels without changing their electrophysiological properties. Nevertheless, the derivative containing the heteroatome N also affects the fast and tetrodotoxin-sensitive sodium channel activity. Thus, only ether and thioether compounds (heteroatome O or S) can be selected for their inhibitory effect on P-type apparented calcium channels.
Lahyani
A
A
Laboratoire de Neurobiologie Cellulaire, Université de Picardie Jules Verne, Amiens, France.
Matifat
F
F
Collin
T
T
Idaomar
M
M
Postel
D
D
Ronco
G
G
Villa
P
P
Brûlé
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry / Q000494:pharmacology*; D009584:Nitrogen / Q000737:chemistry*; D009865:Oocytes / Q000187:drug effects*; D010100:Oxygen / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry*; D009626:Terminology as Topic; D014981:Xenopus
D002121:Calcium Channel Blockers; D009005:Monosaccharides; D013455:Sulfur; D009584:Nitrogen; D010100:Oxygen
Influence de la nature de l'hétéroatome d'un dérivé monosaccharidique sur son action inhibitrice vis à vis de canaux calciques apparentés au type P exprimés dans l'ovocyte de Xenopus.