Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia.
Using a series of yeast artificial chromosomes (YAC) from the Bp11-12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases.
Soenen
V
V
Laboratoire d'Hématologie, Höpital Calmettes, Lille, France.
Chaffanet
M
M
Preudhomme
C
C
Dib
A
A
Lai
J L
JL
Fletcher
J A
JA
Birnbaurn
D
D
Pébusque
M J
MJ
D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic