title: Gemcitabine: clinical and economic impact in inoperable non-small cell lung cancer.
abstract: This study assesses retrospectively the clinical and economic impact of gemcitabine monotherapy on the management of inoperable stage III/IV non-small cell lung cancer in Germany. Based on current methods of clinical practice and using the best outcome data available, the costs and benefits of gemcitabine were compared to a dual therapy (ifosfamide/etoposide). While the two treatments showed broadly equivalent efficacy in terms of tumour response rate and survival, a cost analysis showed the potential for savings with gemcitabine. These largely related to hospital hotelling costs, due to the fact that gemcitabine may be given as an out-patient therapy. Further savings were found in investigative procedures and the management of treatment toxicity. Excluding the cost of the chemotherapy, gemcitabine was associated with potential savings of DM3,026 over two cycles of therapy, which included a 40% decrease in hospitalization costs and a 54% decrease in the cost of managing adverse events. We conclude that gemcitabine monotherapy could offer considerable cost savings while offering the potential for improved quality of palliative treatment compared to existing in-patient treatments, and it may have a place in shifting care from an in-patient to an out-patient setting in line with recent health care reforms.
authors.affiliation: Cambridge Pharma Consultancy, UK.
authors.forename: P
authors.initials: P
authors.lastname: Koch
authors.forename: N
authors.initials: N
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: van Schaik
authors.forename: S
authors.initials: S
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Blatter
authors.forename: N
authors.initials: N
authors.lastname: Bosanquet
authors.forename: K
authors.initials: K
authors.lastname: Copley-Merriman
authors.forename: P
authors.initials: P
authors.lastname: Drings
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000191:economics / Q000473:pathology; D003365:Costs and Cost Analysis; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use; D005858:Germany; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000191:economics / Q000473:pathology; D009367:Neoplasm Staging; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D005047:Etoposide; D007069:Ifosfamide; D000093542:Gemcitabine