Phosphotyrosine-protein-phosphatases and human reproduction: an association between low molecular weight acid phosphatase (ACP1) and spontaneous abortion.
ACP1 (low molecular weight acid phosphatase) genetic polymorphism has been studied in 173 women with a history of two or more consecutive spontaneous abortions and in 1508 control subjects, including 482 normal pregnant women. The proportion of carriers of ACP1*C allele (*A/ *C, *B/*C) in women with a history of repeated spontaneous abortion is lower than in normal pregnant women and other control groups. Women with repeated spontaneous abortion show a specific decrease of ACP1 S isoform concentration as compared to normal pregnant women. The other component of ACP1 activity, the F isoform, does not show a significant difference between the two groups. The data suggest that women with ACP1 genotypes showing a high concentration of S isoform are relatively 'protected' against spontaneous abortion. Preliminary analysis of a sample of 352 normal puerperae along with their newborn babies supports this hypothesis.
Gloria-Bottini
F
F
Chair of Prevention Pediatrics 2nd University of Rome-Torvergata, School of Medicine, Italy.
Nicotra
M
M
Lucarini
N
N
Borgiani
P
P
La Torre
M
M
Amante
A
A
Gimelfarb
A
A
Bottini
E
E
D000026:Abortion, Habitual / Q000201:enzymology* / Q000235:genetics*; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D017027:Protein Tyrosine Phosphatases / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D011518:Proto-Oncogene Proteins; D012098:Reproduction / Q000235:genetics / Q000502:physiology*
D005819:Genetic Markers; D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases