Right and left ventricular geometry and myocyte contractile processes with dilated cardiomyopathy: myocyte growth and beta-adrenergic responsiveness.
OBJECTIVE
Comparison of the effects of supraventricular tachycardia-induced dilated cardiomyopathy on left and right ventricular isolated myocyte geometry and function.


BACKGROUND
Chronic ventricular tachycardia and supraventricular tachycardia cause left ventricular dilation and dysfunction in humans. However, it is unknown whether supraventricular tachycardia-induced dilated cardiomyopathy is a homogenous process for both the left and right ventricles.


METHODS
Dilated cardiomyopathy was induced by rapid atrial pacing (240 beats/min, 3 weeks) in 5 pigs. Five age- and weight-matched pigs served as controls. Ventricular mass was measured, myocyte dimensions were obtained, and isolated right and left ventricular myocyte contractile performance was evaluated at baseline and after beta-adrenergic receptor stimulation.


RESULTS
With the development of dilated cardiomyopathy, there was no change in left ventricular mass. In contrast, right ventricular mass was increased, as was right ventricular myocyte cross-sectional area. In the control group, baseline right ventricular myocyte contractile function was increased compared to left ventricular myocytes. beta-adrenergic receptor stimulation increased myocyte contractile function in both left and right ventricular myocytes. With supraventricular tachycardia-induced cardiomyopathy, both left and right ventricular myocyte contractile function and beta-adrenergic responsiveness were reduced.


CONCLUSIONS
This study demonstrated differences in left and right ventricular myocyte growth with supraventricular tachycardia-induced dilated cardiomyopathy and this differential growth response was associated with changes in contractile performance. Thus, in this model of cardiomyopathic disease, left and right ventricular growth and changes in contractile performance are not a homogenous process.
McMahon
W S
WS
Division of Pediatric Cardiology, Medical University of South Carolina, Charleston 29425, USA.
Mukherjee
R
R
Gillette
P C
PC
Crawford
F A
FA
Spinale
F G
FG
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000473:pathology*; D048429:Cell Size / Q000187:drug effects; D002478:Cells, Cultured; D006352:Heart Ventricles / Q000473:pathology; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000473:pathology*; D011897:Random Allocation; D013268:Stimulation, Chemical; D013552:Swine
D000318:Adrenergic beta-Agonists; D007545:Isoproterenol