title: Lateralization of cutaneous inflammatory responses in patients with unilateral paresis after poliomyelitis.
abstract: Unilateral paresis remaining after poliomyelitis may affect the expression of inflammatory diseases by lateralization of the disease manifestations. The purpose of this study was to assess the impact of the unilateral paresis after poliomyelitis on lateralization of neurogenic inflammation and immune responsiveness. The delayed-type hypersensitivity (DTH) reaction to tuberculin was used as an in vivo measure of antigen-specific T lymphocyte reactivity. Assessment of axon reflex vasodilatation was simultaneously employed to test for neurogenic inflammation. Fourteen of the 16 polio patients displayed a positive DTH reaction to tuberculin. All but two showed weaker DTH reaction on the paretic- compared to the contralateral-side (P = 0.001). Magnitude of electrically evoked axon reflexes significantly correlated to asymmetries of DTH responses. We conclude that damage of lower motor neuron leads to ipsilateral down-regulation of T cell-mediated cutaneous inflammation. This lateralization of DTH responses is related to deficiencies in motor and sympathetic innervation of the paretic extremity.
authors.affiliation: Department of Clinical Immunology, University of Göteborg, Sweden. andrej.tarkowski@microbio.gu.se
authors.forename: E
authors.initials: E
authors.lastname: Tarkowski
authors.forename: H
authors.initials: H
authors.lastname: Naver
authors.forename: B G
authors.initials: BG
authors.lastname: Wallin
authors.forename: C
authors.initials: C
authors.lastname: Blomstrand
authors.forename: G
authors.initials: G
authors.lastname: Grimby
authors.forename: A
authors.initials: A
authors.lastname: Tarkowski
mesh_terms: D000328:Adult; D000368:Aged; D001369:Axons / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000150:complications / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005071:Evoked Potentials; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D010291:Paresis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D011051:Poliomyelitis / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D012882:Skin Tests; D013564:Sympathetic Nervous System / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014664:Vasodilation / Q000276:immunology
chemical_list: D006632:Histamine