title: [Time factor and curietherapy: the example of epidermoid carcinoma of the mobile tongue].
abstract: Experimental evidence exists of a dose-rate effect relationship in low dose continuous irradiation of cell population. In 1952, Paterson drew from his clinical experience on radium 226 implant, a dose-time iso-effect curve. Several authors, reviewing series of squamous cell carcinomas of the mobile tongue, implanted by radium 226 or iridium 192, did not confirm Paterson's hypothesis. Recently, a retrospective analysis of T1 and T2 squamous cell carcinomas, all treated exclusively by iridium 192 at the Henri-Mondor Hospital (Créteil, France), suggested a possible dose-rate effect relationship below 1 Gy/h. However, the role of dose-rate remains unclear. Further experience is needed before definitive conclusions can be drawn.
authors.affiliation: Département de cancérologie, hôpital Henri-Mondor, Créteil Cedex.
authors.forename: J J
authors.initials: JJ
authors.lastname: Mazeron
authors.forename: F
authors.initials: F
authors.lastname: Mornex
mesh_terms: D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D011883:Radium / Q000008:administration & dosage; D012189:Retrospective Studies; D013997:Time Factors; D014062:Tongue Neoplasms / Q000532:radiotherapy*
chemical_list: D007496:Iridium Radioisotopes; D011883:Radium
vernacular_title: Facteur temps et curiethérapie: l'exemple des carcinomes épidermoïdes de la langue mobile.