Acquired free protein S deficiency in children with steroid resistant nephrosis.
Plasma and urine concentrations of protein S were measured in five children with steroid-resistant nephrotic syndrome. It was found that plasma free protein S was reduced in three out of the five patients studied. Thus, acquired free protein S deficiency does occur in children with nephrotic syndrome and is one of many factors which may place them at risk for a thromboembolic event.
Hanevold
C D
CD
Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA.
Lazarchick
J
J
Constantin
M A
MA
Hiott
K L
KL
Orak
J K
JK
D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000378:metabolism; D017293:Protein S / Q000032:analysis* / Q000652:urine; D018455:Protein S Deficiency / Q000209:etiology* / Q000378:metabolism; D011507:Proteinuria / Q000209:etiology; D012307:Risk Factors; D013256:Steroids / Q000494:pharmacology*; D013923:Thromboembolism / Q000209:etiology
D017293:Protein S; D013256:Steroids; D003404:Creatinine