[Electrophysiological evaluation of the demented state and the nootropic effect of TA-0910 by "automated fluctuation analysis" of the high-frequency EEG--relation between neuropsychological test results and Lorentzian parameters].
This study was performed to evaluate the demented state and the nootropic effect of TA-0910 by "Automated Fluctuation Analysis" of the human high-frequency EEG. Correlations between Lorentzian parameters S1 and S2 and the results of neuropsychological tests was investigated. The subjects of this study were 12 demented patients, four males and eight females, aged 57 to 80 years. After obtaining their informed consent a daily dose of 10 mg or 20 mg of TA-0910 was assigned to these subjects one by one. The Kana Hiroi test for pre-frontal lobe function and the Mini Mental State (MMS) test for function of the posterior part of brain were administered before and after the medication period. Particular attention was paid to the consciousness level of the subjects during EEG recording, and EEGs were stored on magnet tape. Statistical analysis was performed by Student's t-test. Improvement in the MMS score from 16.4 +/- 6.2 (mean +/- S.D.) before treatment with TA-0910 to 24.3 +/- 5.7 after treatment was significant (p < 0.001), and a tendency toward dose-dependency was noted. The changes in the traditional EEG did not coincide with these findings but Lorentzian parameters S1 and S2 and the results of the neuropsychological tests correlated well. All of the subjects failed the Kana Hiroi test both before and after the medication period, and in keeping with this finding, the normal frontal dominant pattern of the S1 topographical display was not detected. Furthermore, not only was the elevation of the S2 value significant but the correlation with the MMS scores was also significant, especially in the posterior and right half of the brain. These findings strongly suggest that 1) "Automated Fluctuation Analysis" is very useful not only for evaluating the demented state but for evaluating nootropics as well and 2) TA-0910 activation of subcortical structures, especially A-10, appears to be the mechanism to action.
Nakata
M
M
Medical information Center, Ryukyu University Hospital, University of the Ryukyus School of Medicine, Okinawa, Japan.
D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004569:Electroencephalography / Q000379:methods; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use*; D012815:Signal Processing, Computer-Assisted; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D018697:Nootropic Agents; C065049:TA 0910; D013973:Thyrotropin-Releasing Hormone