title: Myocardial perfusion and function in dogs with moderate coronary stenosis.
abstract: MRI studies of first-pass contrast enhancement with polylysine-Gd-DTPA and myocardial tagging using spatial modulation of magnetization (SPAMM) were performed to assess the feasibility of a combined regional myocardial blood flow and 2D deformation exam. Instrumented closed-chest dogs were imaged at a baseline control state (Cntl) followed by two interventions: moderate coronary stenosis (St) achieved by partial occlusion of the left anterior descending (LAD) and moderate coronary stenosis with dobutamine loading (StD). Hypoperfusion of the anterior region (ANT) of the myocardium (LAD distribution) relative to the posterior wall (POS) based on the upslope of the signal intensity time curve from the contrast-enhanced MR images was demonstrated only with dobutamine loading (ANT:POS Cntl = 1.077 +/- 0.15 versus ANT:POS StD = 0.477 +/- 0.11, P < 0.03) and was confirmed with radiolabeled microspheres measurements (ANT:POS Cntl = 1.18 +/- 0.2 ml/min/g versus ANT:POS StD = 0.44 +/- 0.1 ml/min/g; P < 0.002). Significant changes in regional myocardial shortening were only seen in the StD state (P < 0.02); the anterior region showed impaired myocardial shortening with dobutamine loading (P = NS), whereas the nonaffected POS region showed a marked increase in shortening when compared with Cntl (Cntl = 0.964 +/- 0.02 versus StD = 0.884 +/- 0.03; P < 0.001). These results demonstrate that an integrated quantitative assessment of regional myocardial function and semiquantitative assessment of myocardial blood flow can be performed noninvasively with ultrafast MRI.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia 19104-6021, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Kraitchman
authors.forename: N
authors.initials: N
authors.lastname: Wilke
authors.forename: E
authors.initials: E
authors.lastname: Hexeberg
authors.forename: M
authors.initials: M
authors.lastname: Jerosch-Herold
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: T B
authors.initials: TB
authors.lastname: Parrish
authors.forename: C N
authors.initials: CN
authors.lastname: Chang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: R J
authors.initials: RJ
authors.lastname: Bache
authors.forename: L
authors.initials: L
authors.lastname: Axel
mesh_terms: D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D004280:Dobutamine; D004285:Dogs; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008863:Microspheres; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011107:Polylysine / Q000031:analogs & derivatives*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D004280:Dobutamine; D004369:Pentetic Acid; D019786:Gadolinium DTPA