title: Immunohistochemical and electrophysiological demonstration of substance P in human vestibular ganglion cells.
abstract: This study was performed in order to determine the immunohistochemical expression and distribution pattern as well as the electrophysiological actions of substance P in human vestibular ganglion cells. Substance P-like immunostaining was mainly found in the cytoplasm of small vestibular ganglion cells. In contrast, nerve fibers were not labeled. Using intracellular recording techniques, substance P produced a slow depolarization of membrane potentials accompanied by an increase in membrane resistance. Furthermore, an enhanced firing response to depolarization occurred.
authors.affiliation: ENT-Department, University Hospital of Zürich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Felix
authors.forename: B
authors.initials: B
authors.lastname: Schickinger
authors.forename: D
authors.initials: D
authors.lastname: Felix
mesh_terms: D018929:Cell Culture Techniques; D006801:Humans; D007150:Immunohistochemistry; D013373:Substance P / Q000032:analysis*; D014725:Vestibular Nerve / Q000737:chemistry*
chemical_list: D013373:Substance P