title: Fine-needle sampling of a case of carcinoma of the breast with neuroendocrine differentiation.
abstract: Fine-needle sampling was performed in a woman with a left breast lump. The cytologic diagnosis was consistent with a poorly-differentiated carcinoma. Cytologic features included medium-to-large, round, and spindle-shaped cells with scanty cytoplasm, nuclear molding, and rosette-like structures. Histology revealed an endocrine pattern. Immunohistochemical staining was positive for epithelial and neuroendocrine markers, and electron microscopy showed many small membrane-bound electron-dense granules, confirming the diagnosis of breast carcinoma with neuroendocrine differentiation. DNA flow cytometry and cytogenetic analyses revealed a near-tetraploid tumor.
authors.affiliation: Département de Pathologie, Institut Curie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Veilleux
authors.forename: D
authors.initials: D
authors.lastname: Trophilme
authors.forename: M
authors.initials: M
authors.lastname: Le Charpentier
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
authors.forename: J
authors.initials: J
authors.lastname: Klijanienko
authors.forename: P
authors.initials: P
authors.lastname: Vielh
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008854:Microscopy, Electron; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000235:genetics / Q000473:pathology*; D011123:Polyploidy