Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain.
Using high-performance liquid chromatography, gas-chromatography and chromato-mass spectrometry methods a novel endogenous cyclic dipeptide cyclo-prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 +/- 0.3 nmol/g wet brain. Synthetic cyclo-prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo-prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation.
Gudasheva
T A
TA
Institute of Pharmacology, Russian Academy of Medical Science, Moscow, Russian Federation.
Boyko
S S
SS
Akparov
V Kh
VKh
Ostrovskaya
R U
RU
Skoldinov
S P
SP
Rozantsev
G G
GG
Voronina
T A
TA
Zherdev
V P
VP
Seredenin
S B
SB
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001923:Brain Chemistry; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004597:Electroshock; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D008568:Memory / Q000187:drug effects; D010146:Pain; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
D004151:Dipeptides; D010456:Peptides, Cyclic; C062238:cyclo(prolylglycyl)