title: Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats.
abstract: The anticonvulsant effect of 1-naphthylacetyl spermine (1-NA-Spm), an analogue of Joro spider toxin, against amygdaloid kindled seizures was studied in rats. 1-NA-Spm (10, 20 and 40 micrograms/rat) dose-dependently improved kindled seizures and shortened the afterdischarge duration 30 min after the administration. The anticonvulsant effect was observed even one day after the drug, and then gradually disappeared within 4 days. The present findings demonstrate that 1-NA-Spm acts as a potent and long-acting anticonvulsant against amygdaloid kindled seizures, and also suggest, together with the previous findings, that the calcium-permeable AMPA receptors, which are selectively antagonized by 1-NA-Spm, play a critical role in the seizure generation mechanism of amygdaloid kindling.
authors.affiliation: Department of Neuropsychiatry, Saitama Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takazawa
authors.forename: O
authors.initials: O
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Kanai
authors.forename: N
authors.initials: N
authors.lastname: Ishida
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Yamauchi
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007696:Kindling, Neurologic; D008297:Male; D009498:Neurotoxins; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D013096:Spermine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013111:Spider Venoms
chemical_list: D000925:Anticoagulants; D018691:Excitatory Amino Acid Antagonists; C044936:JSTX spider toxin; D009498:Neurotoxins; D011810:Quinoxalines; D018091:Receptors, AMPA; D013111:Spider Venoms; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; C067506:1-naphthylacetylspermine; D013096:Spermine