In vitro study on the removal of pemphigus antibody with immunoadsorption.
The adsorbability of pemphigus vulgaris (PV) antibodies to immunoadsorbent with phenylalanine, tryptophan, and dextran sulfate as ligands was examined. PV antibodies were adsorbed to immunoadsorbents with both phenylalanine and tryptophan as ligands, in batchwise adsorption and column adsorption. PV antibodies were not adsorbed to immunoadsorbent with dextran sulfate as ligand, in column adsorption. It was also shown that the rates of decrease of normal protein fractions in column adsorption with phenylalanine as a ligand were small. Our results suggest that immunoadsorption therapy using sorbent with phenylalanine as a ligand may be useful for the treatment of PV.
Yamada
H
H
Department of Dermatology, International Goodwill Hospital, Yokohama City, Japan.
Takamori
K
K
Ogawa
H
H
D000906:Antibodies / Q000302:isolation & purification*; D016264:Dextran Sulfate / Q000276:immunology*; D006801:Humans; D007163:Immunosorbent Techniques; D010392:Pemphigus / Q000276:immunology*; D010649:Phenylalanine / Q000276:immunology*; D014364:Tryptophan / Q000276:immunology*
D000906:Antibodies; D010649:Phenylalanine; D014364:Tryptophan; D016264:Dextran Sulfate