Mucormycosis after bone marrow transplantation: report of four cases in thalassemia and review of the literature.
We report four cases of mucormycosis that occurred among 711 patients who underwent BMT for thalassemia, and review 18 additional cases among BMT recipients that were reported in the English-language literature. All these patients were polytransfused and were in advanced phase of disease with severe acquired hemochromatosis. The sites of infection were sinonasal, rhinocerebral-pulmonary, pulmonary and pulmonary-central nervous system. Mucormycosis was the primary cause of death in three of four patients. Two infections were detected within the first 100 days after BMT. Only one of the four patients had partial resolution of sinonasal mucormycosis following aggressive antifungal therapy combined with hyperbaric oxygen treatment.
Gaziev
D
D
Divisione Ematologica e Centro Trapianto Midollo Osseo di Muraglia, Ospedale di Pesaro, Italy.
Baronciani
D
D
Galimberti
M
M
Polchi
P
P
Angelucci
E
E
Giardini
C
C
Muretto
P
P
Perugini
S
S
Riggio
S
S
Ghirlanda
S
S
Erer
B
B
Maiello
A
A
Lucarelli
G
G
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000000981:diagnostic imaging / Q000209:etiology*; D013789:Thalassemia / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous