[Ia antigen expression of peritoneal macrophage in mice model of yang deficiency and the effect of aconitine].
The immune associated (Ia) antigen expression (IAAE) of macrophage is one of the important indicators of the specific immunity in the body. In this paper, mice of Yang Deficiency model was made by injecting corticosterone in the hind legs of mice to inhibit the function of hypothalamus -pituitary-adrenal axis. Authors observed the changes of IAAE in model mice and the effect of Aconitine on it. The results indicated that: (1) In model mice, the IFN-gamma induced IAAE of peritoneal macrophages was inhibited. The difference of IAAE between the model and the normal mice was significant (P < 0.01). (2) Aconitine could significantly increase the IAAE of model mice (P < 0.01). These data implied that the immuno-suppression in the model mice of Yang Deficiency might be due to the lowered IAAE of macrophages under this condition. The promoting effects of Aconitine on IAAE enhanced the antigen presenting ability of macrophages and the immune response of the model mice. It might be related to the therapeutic mechanism of Aconitine on Yang Deficiency Syndrome.
Ma
J
J
Nanjing University of TCM.
Fan
Q L
QL
Mitsuhiro
M
M
D000157:Aconitine / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000276:immunology*; D051379:Mice; D016711:Yang Deficiency / Q000139:chemically induced / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000949:Histocompatibility Antigens Class II; D003345:Corticosterone; D000157:Aconitine