Increased serum human granulocyte colony-stimulating factor (G-CSF) levels following intravenous infusion of high-dose methylprednisolone.
Serum granulocyte colony-stimulating factor (G-CSF) level were measured for 24 h in 6 patients with hematological disorders and two patients with Graves' disease associated with malignant exophthalmos after iv infusion of high-dose methylprednisolone (HDMP) (20 mg/kg BW) for 2 h starting at 0900 h. Saline solution (500 ml) was infused iv for 2 h as a control on two days before starting the HDMP therapy. Serum G-CSF levels increased with the mean peak values at 4 h after the HDMP therapy (mean +/- SD: 488.1 +/- 125.8 pg/ml vs. saline control 74.4 +/- 21.9 pg/ml, P < 0.01). Circulating absolute neutrophil counts (ANC) also increased with the mean peak values at 24 h after the HDMP (6,057 +/- 1,460 / microliters vs. saline control 2,007 +/- 390 / microliters, P < 0.025). These findings indicate that glucocorticoid has a stimulating effect on G-CSF release and that the increased G-CSF release could be involved, at least partly, in neutrophilia induced by glucocorticoid.
Wakayama
T
T
Department of Medicine, Shimane Medical University, Izumo, Japan.
Sohmiya
M
M
Furuya
H
H
Murakami
Y
Y
Kato
Y
Y
D000328:Adult; D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006111:Graves Disease / Q000097:blood / Q000188:drug therapy; D006402:Hematologic Diseases / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D007700:Kinetics; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged
D016179:Granulocyte Colony-Stimulating Factor; D008775:Methylprednisolone