[A model for the study of the ototoxic effects of drugs in an experiment].
The authors compared sensitivity of the acoustic analyzer elements to ototoxic drugs in cat experiments. The model proposed assesses primary responses of the brain cortical acoustic zone (BCAZ) to sound stimulation. The drugs effect on the analyzer's periphery was determined from changes in bioelectric responses of the cochlea to sound stimulation (microphone potential, potential of the acoustic nerve action). The arguments are presented for feasibility of using primary BCAZ responses evoked by electric stimulation of thalamocortical radiation fibers coming from the medial geniculate body for examination of the drug effects on the analyzer's cortex. Parallel registration of the above bioelectrical reactions in the same animal for a long time makes it possible to compare sensitivity of different elements of the acoustic analyzer to ototoxic medication.
Fisenko
V P
VP
Guseĭnov
N M
NM
D000161:Acoustic Stimulation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects / Q000502:physiology; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005260:Female; D008297:Male; D009430:Neural Analyzers / Q000187:drug effects* / Q000502:physiology; D013307:Streptomycin / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D013307:Streptomycin
Model' dlia izucheniia ototoksicheskikh éffektov lekarstvennykh sredstv v éksperimente.