NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs.
Using quantitative in situ hybridization, a significant decrease in expression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%) is observed in the rat caudate-putamen 14 days after daily intraperitoneal administration of N-methyl-D-aspartate receptor antagonist MK-801, 2 mg/kg.
Zhang
F
F
Brain Research Unit and Laboratory of Neuropathology and Neuropeptide Research, Université Libre de Bruxelles, Belgium.
Van Bree
L
L
Albala
N
N
Verslype
M
M
Vanderhaeghen
J J
JJ
D000818:Animals; D001345:Autoradiography; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D004745:Enkephalins / Q000096:biosynthesis*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D017403:In Situ Hybridization; D007274:Injections, Intraperitoneal; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D011498:Protein Precursors / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D015320:Tachykinins / Q000096:biosynthesis*
D004745:Enkephalins; D018691:Excitatory Amino Acid Antagonists; D011498:Protein Precursors; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D015320:Tachykinins; C029992:proenkephalin; C054618:protachykinin; D016291:Dizocilpine Maleate