[Detection of trisomy 3 in angioimmunoblastic lymphadenopathy with dysproteinemia by fluorescence in situ hybridization].
Using fluorescence in situ hybridization, we have detected trisomy 3 and the frequency of cells with +3 in 36 patients with AILD. In 36 cases 28 (77.8%) were found having trisomy 3, which was far exceeded that observed in metaphase cytogenetic study (+3 in 15 cases, 42%). Meanwhile, the frequency of cells with +3 was only 4.0%, which was much lower than that of 11.2% in metaphase cytogenetics. The study indicate that the trisomy 3 is a characteristic chromosome aberration of AILD, the cells with +3 constitute only a small part of the specimen, the fluorescence in situ hybridization is more sensitive than metaphase cytogenetics in detection of numerical chromosome aberrations.
Zhang
Y
Y
Zhejiang Branch of CAMS, Hangzhou.
Brigitte
S
S
D000328:Adult; D000368:Aged; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D014314:Trisomy