title: A pilot study of the effects of a perflubron emulsion, AF 0104, on mixed venous oxygen tension in anesthetized surgical patients.
abstract: A pilot study of a perfluorochemical (PFC) emulsion was undertaken to determine whether administration of a perflubron emulsion could result in measurable changes in mixed venous oxygen tension. Seven adult surgical patients received a 0.9-g PFC/kg intravenous dose of perflubron emulsion after acute normovolemic hemodilution (ANH). Hemodynamic and oxygen transport data were collected before and after ANH, immediately after PFC infusion, and at approximate 15-min intervals throughout the surgical period. There were no clinically significant hemodynamic changes associated with the administration of the PFC emulsion. There was a significant increase in mixed venous oxygen tension (PVO2) after the PFC infusion, while cardiac output and oxygen consumption were unchanged. As surgery progressed, the hemoglobin concentration decreased with ongoing blood loss while PVO2 values remained at or above predosing levels. Peak perflubron blood levels were 0.8 g/dL immediately postinfusion, and approximately 0.3 g/dL at 1 h. This pilot study demonstrates that administration of perflubron emulsion results in measurable changes in mixed venous oxygen tension during intraoperative ANH.
authors.affiliation: Department of Anesthesiology, University of Michigan, Ann Arbor 48109-0048, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Wahr
authors.forename: A
authors.initials: A
authors.lastname: Trouwborst
authors.forename: R K
authors.initials: RK
authors.lastname: Spence
authors.forename: C P
authors.initials: CP
authors.lastname: Henny
authors.forename: A C
authors.initials: AC
authors.lastname: Cernaianu
authors.forename: G P
authors.initials: GP
authors.lastname: Graziano
authors.forename: K K
authors.initials: KK
authors.lastname: Tremper
authors.forename: K E
authors.initials: KE
authors.lastname: Flaim
authors.forename: P E
authors.initials: PE
authors.lastname: Keipert
authors.forename: N S
authors.initials: NS
authors.lastname: Faithfull
authors.forename: J J
authors.initials: JJ
authors.lastname: Clymer
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D001692:Biological Transport / Q000187:drug effects; D004655:Emulsions; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D006438:Hemodilution / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006842:Hydrocarbons, Brominated; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D010865:Pilot Projects; D013514:Surgical Procedures, Operative
chemical_list: D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron; D010100:Oxygen