title: Hydrops fetalis and neonatal leukemia in Down syndrome.
abstract: Four newborn infants with Down syndrome and manifestations of neonatal leukemia are described. One of the four was stillborn, two died shortly after birth, and a fourth survived and all evidence of leukemia disappeared in the first month of life. Three of the four cases had hydrops fetalis, and a fourth was a macerated stillborn. Nine other similar reported cases are reviewed. We conclude that neonatal leukemia in Down syndrome is a form of leukemia that is usually transient, with spontaneous recovery, but may be fatal at or around the time of birth with manifestations of hydrops fetalis, hepatosplenomegaly, and/or progressive liver disease.
authors.affiliation: Department of Pediatrics, The Hospital for Sick Children, and the University of Toronto, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Zipursky
authors.forename: T
authors.initials: T
authors.lastname: Rose
authors.forename: M
authors.initials: M
authors.lastname: Skidmore
authors.forename: P
authors.initials: P
authors.lastname: Thorner
authors.forename: J
authors.initials: J
authors.lastname: Doyle
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology*; D007231:Infant, Newborn; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology*; D008297:Male; D011247:Pregnancy