Model building of antibody combining sites.
The number of high quality crystal structures of antibody fragments available in the Brookhaven Protein Data Bank is rapidly increasing. These structures provide a substantial knowledge base and support model building of novel antibody combining sites. We review some basic principles of antibody structure, describe structure-based modelling procedures, and indicate the strengths and weaknesses of the modelling approach. Applications of antibody models are discussed.
Bajorath
J
J
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA.
Novotny
J
J
D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D001666:Binding Sites, Antibody; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation
D000906:Antibodies