title: [Diastolic left ventricular dysfunction with microvascular angina (Syndrome X)].
abstract: Findings on left ventricular function in microvascular angina (syndrome X) are somewhat controversial. Recently, an increased prevalence of insulin resistance and hyperlipoproteinemia has been demonstrated as well as arterial hypertension potentially impairing the left ventricular diastolic function. In an attempt to analyze the diastolic function at rest, we investigated by Doppler echocardiography the transmitral blood flow in 16 patients (51 +/- 8 years). The diastolic data were compared with those of 12 healthy people (50 +/- 6 years) who were matched for age. The patients with microvascular angina revealed a slightly higher systolic blood pressure (134 +/- 18 mm Hg vs 125 +/- 9 mm Hg, n.s.), but imposed by higher left ventricular mass index (92 +/- 18 g/m2 vs 65 +/- 13 g/m2, p < 0.001). There was a trend to an elevated A-wave-peak during transmitral blood flow (61 +/- 14 cm/s vs 50 +/- 9 cm/s). The findings suggest impairment of the left ventricular relaxation before manifestation of left ventricular hypertrophy and hypertension takes place.
authors.affiliation: Abteilung fur Kardiologie, Medizinische Klinik und Poliklinik, Universitats-Krankenhaus Eppendorf, Hamburg.
authors.forename: K
authors.initials: K
authors.lastname: Langes
authors.forename: C A
authors.initials: CA
authors.lastname: Nienaber
authors.forename: C
authors.initials: C
authors.lastname: Caroli
authors.forename: C
authors.initials: C
authors.lastname: Volk
authors.forename: D H
authors.initials: DH
authors.lastname: Koschyk
authors.forename: T
authors.initials: T
authors.lastname: Hofmann
authors.forename: T
authors.initials: T
authors.lastname: Meinertz
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*
vernacular_title: Diastolische linksventrikulare Dysfunktion bei Mikreovaskular-Angina (Syndrom X).