title: Abnormalities of torsional fast phase eye movements in unilateral rostral midbrain disease.
abstract: In a patient with a unilateral rostral midbrain lesion, three-dimensional scleral search coil eye movement recordings demonstrated slowing of ipsidirectional torsional fast phase eye movements without any abnormalities of torsional slow phases. On high-resolution MRI, the brainstem lesion localized to the area of the efferent pathways from the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF). This supports the experimental finding that unilateral inactivation of the riMLF results in a loss of ipsidirectional torsional fast phase eye movements and the hypothesis that there is lateralization of function throughout the torsional fast eye movement generating system.
authors.affiliation: Neuro-Otology Section, MRC Human Movement and Balance Unit, Institute of Neurology, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Riordan-Eva
authors.forename: M
authors.initials: M
authors.lastname: Faldon
authors.forename: J A
authors.initials: JA
authors.lastname: Büttner-Ennever
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: A M
authors.initials: AM
authors.lastname: Bronstein
authors.forename: M A
authors.initials: MA
authors.lastname: Gresty
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology*; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon / Q000473:pathology / Q000503:physiopathology*