Endothelin receptor heterogeneity, G-proteins, and signaling via cAMP and cGMP cascades.
1. The endothelins (ETs) are potent vasoactive peptides which are involved in diverse biological processes, such as contraction, neuromodulation, and neurotransmission, as well as in certain pathophysiological conditions including cardiac and renal failure. 2. The diversity of action of ETs may be attributed to (i) the existence of a number of receptor subtypes, and (ii) the G-protein-mediated activation of different signal transduction pathways. 3. The combined action of these two variables modulates the response, since different receptor subtypes can stimulate and/or inhibit the cAMP and cGMP cascades.
Sokolovsky
M
M
Laboratory of Neurobiochemistry, Tel Aviv University, Israel.
D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D016232:Endothelins / Q000737:chemistry / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D017466:Receptors, Endothelin / Q000737:chemistry / Q000502:physiology*; D018000:Receptors, Peptide / Q000737:chemistry / Q000502:physiology; D015290:Second Messenger Systems; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014757:Viper Venoms / Q000737:chemistry
D016232:Endothelins; D017466:Receptors, Endothelin; D018000:Receptors, Peptide; D014757:Viper Venoms; C058085:sarafotoxin receptor; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D006152:Cyclic GMP