Phenylephrine increases cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons.
BACKGROUND
Although low-flow cardiopulmonary bypass (CPB) has become a preferred technique for the surgical repair of complex cardiac lesions in children, the relative hypotension and decrease in cerebral blood flow (CBF) associated with low flow may contribute to the occurrence of postoperative neurologic injury. Therefore, it was determined whether phenylephrine administered to increase arterial blood pressure during low-flow CPB increases CBF.


METHODS
Cardiopulmonary bypass was initiated in seven baboons during fentanyl, midazolam, and isoflurane anesthesia. Animals were cooled at a pump flow rate of 2.5 l.min-1.m-2 until esophageal temperature decreased to 20 degrees C. Cardiopulmonary bypass flow was then reduced to 0.5 l.min-1.m-2 (low flow). During low-flow CPB, arterial partial pressure of carbon dioxide (Pco2) and blood pressure were varied in random sequence to three conditions: (1) Pco2 30-39 mmHg (uncorrected for temperature), control blood pressure; (2) Pco2 50-60 mmHg, control blood pressure; and (3) Pco2 30-39 mmHg, blood pressure raised to twice control by phenylephrine infusion. Thereafter, CPB flow was increased to 2.5 l.min-1.m-2, and baboons were rewarmed to normal temperature. Cerebral blood flow was measured by washout of intraarterial 133Xe before and during CPB.


RESULTS
Phenylephrine administered to increase mean blood pressure from 23 +/- 3 to 46 +/- 3 mmHg during low-flow CPB increased CBF from 14 +/- 3 to 31 +/- 9 ml.min-1.100 g-1, P < 0.05. Changes in arterial Pco2 alone during low flow bypass produced no changes in CBF.


CONCLUSIONS
Although low-flow CPB resulted in a marked decrease in CBF compared with prebypass and full-flow bypass, phenylephrine administered to double arterial pressure during low-flow bypass produced a proportional increase in CBF.
Schwartz
A E
AE
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Minanov
O
O
Stone
J G
JG
Adams
D C
DC
Sandhu
A A
AA
Pearson
M E
ME
Kwiatkowski
P
P
Young
W L
WL
Michler
R E
RE
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006400:Hematocrit; D007036:Hypothermia, Induced; D008297:Male; D010215:Papio; D010656:Phenylephrine / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D010656:Phenylephrine