title: Low incidence of serotonin-induced occlusive coronary artery spasm in patients with recent myocardial infarction.
abstract: Intracoronary infusion of serotonin has been reported to induce varying degrees of coronary vasoconstriction in different coronary syndromes, but it has never been studied in patients after myocardial infarction. In patients with recent myocardial infarction, we found a low incidence (11%) of serotonin-induced occlusive spasm only in the infarct-related artery (IRA), and a significantly higher vasoconstriction in the distal segment of the IRA than in the same segment of the non-IRA.
authors.affiliation: Institute of Cardiology, Catholic University of Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Mongiardo
authors.forename: M L
authors.initials: ML
authors.lastname: Finocchiaro
authors.forename: J
authors.initials: J
authors.lastname: Beltrame
authors.forename: C
authors.initials: C
authors.lastname: Pristipino
authors.forename: A
authors.initials: A
authors.lastname: Lombardo
authors.forename: D
authors.initials: D
authors.lastname: Cianflone
authors.forename: M A
authors.initials: MA
authors.lastname: Mazzari
authors.forename: A
authors.initials: A
authors.lastname: Maseri
mesh_terms: D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D012701:Serotonin; D007548:Isosorbide Dinitrate