Toxicity of organic chemicals to fathead minnow: a united quantitative structure-activity relationship model and its application.
A general and practical relation has been established between structure and activity of organic chemicals based on target theory. This relation was tested by examining the correlations between the acute toxicity and the physicochemical properties for fathead minnow, which showed that this relation can explain the observed toxicity data and phenomena successfully. The equations are then used to estimated the acute toxicity data of organic chemicals, and the predicted values are close to observed values.
Feng
L
L
Department of Environmental Science and Engineering, Nanjing University, P. R. China.
Han
S
S
Zhao
Y
Y
Wang
L
L
Chen
J
J
D000818:Animals; D003530:Cyprinidae; D004784:Environmental Monitoring / Q000379:methods; D007928:Lethal Dose 50; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000187:drug effects; D013329:Structure-Activity Relationship; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D011956:Receptors, Cell Surface; D014874:Water Pollutants, Chemical