title: Malignant acanthosis nigricans with florid papillary oral lesions.
abstract: Acanthosis nigricans is a distinctive skin disease of importance, because it has served as an external marker for a variety of systemic disorders including endocrinopathies, and malignant tumors of internal organs. It typically appears as hyperpigmented, roughened plaques of velvety consistency and infrequently as verruca-like papillations. The oral cavity and lips can be affected by florid papillary growths. Because of its rarity and nonspecific microscopic appearance, clinical recognition of acanthosis nigricans continues to be a challenge. A case of mucocutaneous "malignant" acanthosis nigricans is presented in which pigmented skin lesions led to the discovery of a gastric adenocarcinoma, which in turn was followed by the appearance of massive oral papillomatosis. No effective treatment was found.
authors.affiliation: Division of Oral Medicine and Radiology, Faculty of Dentistry, McGill University, Montreal, Québec, Canada.
authors.forename: M T
authors.initials: MT
authors.lastname: Tyler
authors.forename: G
authors.initials: G
authors.lastname: Ficarra
authors.forename: S
authors.initials: S
authors.lastname: Silverman
authors.forename: R B
authors.initials: RB
authors.lastname: Odom
authors.forename: J A
authors.initials: JA
authors.lastname: Regezi
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications / Q000473:pathology*; D000230:Adenocarcinoma / Q000150:complications* / Q000556:secondary; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000473:pathology*; D009102:Multiple Organ Failure / Q000209:etiology; D010212:Papilloma / Q000150:complications / Q000473:pathology*; D013274:Stomach Neoplasms / Q000150:complications*