[Detection of resistance to the amoxicillin-clavulamic acid combination in Salmonella and Shigella].
OBJECTIVE
To study the emergence of amoxicilline/clavulanate resistance in Salmonella and Shigella.


METHODS
We have studied 118 strains of Salmonella enterica and 11 strains of Shigella flexneri isolated in our laboratory along 1993. The MICs values for amoxicilline/clavulanate were determined by the E-Test method and confirmed by the standard agar dilution method.


RESULTS
We have observed that 6% (7 out of 118 strains) of Salmonella enterica and 42% (5 out of 11 strains) of Shigella flexneri isolates exhibited an intermediate susceptibility or were resistant to amoxicilline/clavulanate with MICs values ranging between 16 mg/l and 32 mg/l.


CONCLUSIONS
Along 1993 we have detected the emergence of an amoxicilline/clavulanate resistance in salmonellae and shigellae strains. To our knowledge this fact has not been published up to now (Medline, 1990-October 1994). We don't know the clinical importance of this fact.
Miró
E
E
Servicio de Microbiología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona.
Mirelis
B
B
Navarro
F
F
Prats
G
G
D000658:Amoxicillin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D002969:Clavulanic Acids / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D012477:Salmonella enteritidis / Q000187:drug effects*; D012763:Shigella flexneri / Q000187:drug effects*
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Detección de resistencia a la asociación amoxicilina-ácido clavulánico en Salmonella y Shigella.