title: [Histomorphometry of bone in clinical practice and research].
abstract: Short overview of importance and principles of histology and histomorphometry of bone tissue patterns performed in IIIrd internal clinic since 1978 is described. Since the beginning, 736 bone biopsy patterns were taken. Generally there are two groups of indications for bone tissue investigation: differential diagnosis of osteologic or hematologic diseases, or investigational indication in a research study. Short overview of morphometric results, gained in IIIrd internal clinic is stated. Histomorphometric parameters of acromegalic and normal trabecular bone were compared and results and consequences for architecture of trabecular bone are described. No correlation between levels of somatotropin or somatomedin C and histomorphometric parameters was found out. Principles of further investigation in IIIrd internal clinic are outlined.
authors.affiliation: III. interní klinika, 1. lékarské fakulty, Univerzity Karlovy, Praha, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Zák
mesh_terms: D000172:Acromegaly; D001847:Bone Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D016723:Bone Remodeling; D001842:Bone and Bones / Q000473:pathology*; D004700:Endocrine System Diseases / Q000150:complications; D006801:Humans
vernacular_title: Histomorfometrie kosti v klinické praxi a výzkumu.