title: Comparison of magnetic resonance imaging and transvaginal ultrasonography with hysterosalpingography in the evaluation of women exposed to diethylstilbestrol.
abstract: OBJECTIVE
  To compare the ability of magnetic resonance imaging (MRI) and transvaginal ultrasound (TV-US) with that of hysterosalpingography (HSG) in detecting uterine abnormalities caused by in utero diethylstilbestrol (DES) exposure.
  
  
  METHODS
  The study was a prospective MRI and TV-US blind comparison of DES-exposed and nonexposed subjects who had had previous HSG for infertility evaluation.
  
  
  RESULTS
  MRI identified uterine constrictions in 60% of patients and T-shaped uteri in 25% of DES-exposed patients with HSG-confirmed abnormalities. TV-US did not identify uterine constrictions or T-shaped uteri in DES-exposed patients.
  
  
  CONCLUSIONS
  HSG must still be considered the preferred method in evaluating DES-related uterine abnormalities. HSG-defined uterine abnormalities associated with in utero DES exposure were variably identified by MRI and not at all by TV-US.
authors.affiliation: Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, D.C., USA.
authors.forename: S
authors.initials: S
authors.lastname: Kipersztok
authors.forename: M
authors.initials: M
authors.lastname: Javitt
authors.forename: M C
authors.initials: MC
authors.lastname: Hill
authors.forename: R J
authors.initials: RJ
authors.lastname: Stillman
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000075202:Contraindications; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007047:Hysterosalpingography / Q000592:standards*; D008279:Magnetic Resonance Imaging / Q000592:standards*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D014463:Ultrasonography / Q000592:standards*; D014599:Uterus / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol