title: Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature.
abstract: Cutis laxa acquisita is a rare disorder that affects collagen and elastin metabolism. The cause is unknown. Characteristic features include sagging and laxity of the skin, as well as involvement of the lungs, heart, gastrointestinal system, and urogenital tract. Three cases of cutis laxa acquisita have been reported in association with multiple myeloma. Due to the rarity of these disorders, a linkage has been postulated. The clinical and histologic data from the fourth case of cutis laxa acquisita associated with multiple myeloma were compared to the three other cases previously reported in the literature. The relationship between acquired cutis laxa and multiple myeloma is unclear, with only one case revealing possible immune-mediated elastin destruction via IgG immunoglobulin bound to dermal elastin fibers on immunofluoresence examination. No pattern in the clinical courses of the disorder can be seen on review of the four cases with coincident disease. We hypothesize that cutis laxa acquisita represents a paraneoplastic process of multiple myeloma, given the rarity of these diseases. Further investigation is necessary to determine the underlying linkage between these disorders. We suggest that serum and urine protein electrophoresis results be obtained in patients presenting with cutis laxa acquisita to screen for multiple myeloma given this association.
authors.affiliation: Hematology/Oncology Service, Womack Army Medical Center, Fort Bragg, North Carolina, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: McCarty
authors.forename: J M
authors.initials: JM
authors.lastname: Davidson
authors.forename: J S
authors.initials: JS
authors.lastname: Cardone
authors.forename: L L
authors.initials: LL
authors.lastname: Anderson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003483:Cutis Laxa / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D004549:Elastin / Q000097:blood / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D004549:Elastin