title: Experimental intraperitoneal administration of cisplatin-activated carbon for rat ovarian adenocarcinomas.
abstract: Selective delivery of a high level of cisplatin (CDDP) to the omentum, intraperitoneal disseminated tumors and lymph nodes was studied using a dosage form of CDDP-activated carbon. Although intraperitoneal CDDP-activated carbon delivered much higher levels of CDDP to the omentum, tumors and lymph nodes, a primary burst phenomenon of CDDP occurred just after administration. This indicates that activated carbon is an unsuitable particle to provide a slow steady release of CDDP.
authors.affiliation: Department of Obstetrics and Gynecology, Kurume University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: S
authors.initials: S
authors.lastname: Kumagai
authors.forename: K
authors.initials: K
authors.lastname: Ushijima
authors.forename: A
authors.initials: A
authors.lastname: Shinagawa
authors.forename: H
authors.initials: H
authors.lastname: Okina
authors.forename: Y
authors.initials: Y
authors.lastname: Tomioka
authors.forename: A
authors.initials: A
authors.lastname: Kataoka
authors.forename: M
authors.initials: M
authors.lastname: Yakushiji
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002244:Carbon; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D007274:Injections, Intraperitoneal; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D002244:Carbon; D002945:Cisplatin