0.05% clobetasol 17-propionate cream and ointment but not the corresponding 0.1% triamcinolone acetonide preparations increase skin surface roughness: a possible dissociation of unwanted epidermal and dermal effects.
Repeated open application of clobetasol 17-propionate cream and ointment to normal skin over a period of 6 weeks induced an increase in skin surface roughness as assessed by profilometry (p < 0.05), while 6 weeks' application of triamcinolone acetonide cream and ointment did not. The increase in skin roughness with clobetasol 17-propionate cream turned out to be greater than with ointment containing identical amounts of clobetasol 17-propionate (p < 0.05). A clear-cut correlation between increase of skin surface roughness and skin thickness as assessed by high-frequency ultrasound could be demonstrated only with clobetasol 17-propionate cream and ointment.
Kerscher
M J
MJ
Dermatologische Klinik, Ludwig-Maximilians-Universität, München, Deutschland.
Korting
H C
HC
Mehringer
L
L
Mätzig
R
R
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000494:pharmacology; D017453:Dermatitis, Irritant / Q000209:etiology; D004304:Dosage Forms; D004311:Double-Blind Method; D005260:Female; D005542:Forearm; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D009824:Ointments; D012867:Skin / Q000187:drug effects*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D004304:Dosage Forms; D005938:Glucocorticoids; D009824:Ointments; D002990:Clobetasol; D014222:Triamcinolone Acetonide