title: A defect in nurturing in mice lacking the immediate early gene fosB.
abstract: Although expression of the Fos family of transcription factors is induced by environmental stimuli that trigger adaptive neuronal response, evidence that Fos family members mediate these responses is lacking. To address this issue, mice were generated with an inactivating mutation in the fosB gene. fosB mutant mice are profoundly deficient in their ability to nurture young animals but are normal with respect to other cognitive and sensory functions. The nurturing defect is likely due to the absence of FosB in the preoptic area, a region of the hypothalamus that is critical for nurturing. These observations suggest that a transcription factor controls a complex behavior by regulating a specific neuronal circuit and indicate that nurturing in mammals has a genetic component.
authors.affiliation: Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Brown
authors.forename: H
authors.initials: H
authors.lastname: Ye
authors.forename: R T
authors.initials: RT
authors.lastname: Bronson
authors.forename: P
authors.initials: P
authors.lastname: Dikkes
authors.forename: M E
authors.initials: ME
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000502:physiology; D017781:Genes, Immediate-Early / Q000502:physiology*; D007150:Immunohistochemistry; D007743:Labor, Obstetric / Q000235:genetics; D007774:Lactation / Q000235:genetics; D008297:Male; D008321:Mammary Glands, Animal / Q000502:physiology; D008425:Maternal Behavior / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout / Q000502:physiology*; D009154:Mutation / Q000502:physiology; D010641:Phenotype; D011247:Pregnancy; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000235:genetics*; D012903:Smell / Q000502:physiology
chemical_list: D016760:Proto-Oncogene Proteins c-fos