Cytotoxic cycloartanes from Aglaia argentea.
Aglaia argentea leaves yielded three new cycloartanes: argenteanones A and B, and argenteanol. The first two possess cytotoxic activity against KB cells (IC50 7.5 micrograms ml-1 and 6.5 micrograms ml-1 respectively). Structural elucidation was done by two-dimensional NMR spectroscopy.
Omobuwajo
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Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France.
Martin
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Perromat
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Sevenet
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Awang
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Païs
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D002470:Cell Survival / Q000187:drug effects*; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes
D003603:Cytotoxins; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C085352:cycloartane