Peracute disseminated fatal Aspergillus fumigatus sepsis as a complication of corticoid-treated systemic lupus erythematosus.
Immunocompromised and granulocytopenic patients and those receiving long-term or high-dose corticoid treatment are predisposed to disseminating Aspergillus infections. However, Aspergillus infection has been described only rarely in patients with autoimmune diseases. We report on a woman suffering from systemic lupus erythematosus treated by antibiotics and high-dose corticosteroids, a primary risk factor, who developed a peracute disseminated fatal Aspergillus fumigatus infection involving the central nervous system. The present case is compared with 10 previous reports of invasive aspergillosis in systemic lupus erythematosus found by a literature search.
Nenoff
P
P
Department of Dermatology, University of Leipzig, Germany.
Horn
L C
LC
Mierzwa
M
M
Leonhardt
R
R
Weidenbach
H
H
Lehmann
I
I
Haustein
U F
UF
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001228:Aspergillosis / Q000209:etiology*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000209:etiology*; D006321:Heart / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D012307:Risk Factors
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents