title: Fluoxetin-induced pulmonary granulomatosis.
abstract: A patient treated with fluoxetin for a manic depressive disorder developed pulmonary inflammatory nodules with noncaseating giant cell granulomas, interstitial pneumonia and non-necrotizing vasculitis, whilst remaining asymptomatic. A progressive resolution of pulmonary nodules occurred after withdrawal of the offending agent, and the chest radiograph returned to normal in 9 months. The diagnosis was assessed by an open lung biopsy.
authors.affiliation: Service de Radiologie, Hôpital Saint-Louis, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: de Kerviler
authors.forename: J
authors.initials: J
authors.lastname: Trédaniel
authors.forename: G
authors.initials: G
authors.lastname: Revlon
authors.forename: O
authors.initials: O
authors.lastname: Groussard
authors.forename: G
authors.initials: G
authors.lastname: Zalcman
authors.forename: J M
authors.initials: JM
authors.lastname: Ortoli
authors.forename: M
authors.initials: M
authors.lastname: Espié
authors.forename: A
authors.initials: A
authors.lastname: Hirsch
authors.forename: J
authors.initials: J
authors.lastname: Frija
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006101:Granuloma, Giant Cell / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine