Audit of referral and explant diagnoses in lung transplantation: a pathologic study of lungs removed for parenchymal disease.
BACKGROUND
Lung transplantation is performed for an increasing range of pulmonary conditions in which the diagnosis is often clinical or based on limited biopsy material. Diagnosis may be made late in the course of the disease where specific features are no longer present. Posttransplantation complications and disease recurrence may relate to the primary disease, and accurate diagnosis is therefore essential.


RESULTS
A pathologic review of 183 explanted lungs over a 10-year period (heart-lung = 109, single lung = 65, double lung = 9) showed 29 significant discrepancies or additional features likely to effect outcome. The final pathologic diagnosis was cystic fibrosis (n = 66), emphysema (59), bronchiectasis (17), pulmonary fibrosis (19), sarcoidosis (10), Langerhans cell histiocytosis (3), pulmonary veno-occlusive disease (3), posttransplantation obliterative bronchiolitis (2), primary hemosiderosis (1), rheumatoid obliterative bronchiolitis (1), extrinsic allergic alveolitis (1), pneumoconiosis (1). Unsuspected diagnoses included tuberculosis (8) (four cases of which were active and in single lung recipients requiring antituberculous chemotherapy), sarcoidosis (9), (of which, six were unsuspected primary diagnoses and three were additional diagnoses), veno-occlusive disease (3), carcinoma (1), pneumoconiosis (1), and pulmonary fibrosis (2). Aspergillus infection (2) and bronchocentric granulomatosis (3) were found in patients with cystic fibrosis. One active tuberculosis case also showed an aspergilloma. Unsuspected infections requiring therapy in immunosuppressed patients and previously unsuspected sarcoidosis, which is known to recur in the graft, were the major novel diagnoses. Discrepancy rate was 12 of 65 in single lungs (19%) and 17 of 109 in heart-lungs (16%).


CONCLUSIONS
These results emphasize the need for accurate preoperative diagnosis especially when the similarly diseased native lung remains in situ.
Stewart
S
S
Transplantation Unit, Papworth Hospital, Cambridge, United Kingdom.
McNeil
K
K
Nashef
S A
SA
Wells
F C
FC
Higenbottam
T W
TW
Wallwork
J
J
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D016041:Heart-Lung Transplantation / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology / Q000601:surgery*; D016040:Lung Transplantation / Q000473:pathology*; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology; D012008:Recurrence; D012017:Referral and Consultation; D012307:Risk Factors