Contributions of an orthopteran to the understanding of neuronal pathfinding.
During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specific interaction of receptors on the neuronal surface with molecular cues in the environment. We review the information obtained in an invertebrate model system, the grasshopper embryo, about the specific role of the cell surface in wiring the nervous system.
Sanchez
D
D
Biology Department, University of Utah, Salt Lake City 84112, USA.
Ganfornina
M D
MD
Bastiani
M J
MJ
D000818:Animals; D001369:Axons / Q000378:metabolism; D006110:Grasshoppers / Q000033:anatomy & histology / Q000196:embryology*; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000378:metabolism; D008565:Membrane Proteins / Q000096:biosynthesis / Q000378:metabolism; D008953:Models, Anatomic; D009420:Nervous System / Q000033:anatomy & histology / Q000196:embryology* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism
D008562:Membrane Glycoproteins; D008565:Membrane Proteins