[Association of 5-FU, CDDP and hypofractionated radiotherapy in recurrences of subtentorial astrocytomas and malignant gliomas in adults].
Twenty-seven patients who had a relapse of astrocytomas or supra-tentorial malignant gliomas, previously treated by radio-surgical combination or exclusive irradiation, underwent a combination of 3 courses of 5-FU, cis-platyl and hypofractionated irradiation. No objective response was observed, but there was a progression of the tumor in 33% of the cases, and no change in 67%. Overall median survival was 7 +/- 1.5 months. The 20 patients with grade III or IV astrocytomas had a lower median rate than the 7 patients with grade II astrocytomas or oligodendrogliomas: 6 +/- 1.8 months versus 18 +/- 3.2 (P = 0.16). Median survival was 14 +/- 2.7 months for neurological responders and 6 +/- 2.1 months for non-responders (P = 0.017).
Bolla
M
M
Service de radiothérapie, hôpital A-Michallon, Grenoble, France.
Vincent
P
P
Benabid
A
A
Mousseau
M
M
de Rougemont
J
J
Vrousos
C
C
Kolodié
H
H
Vincent
F
F
Pasquier
B
B
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005625:Frontal Lobe; D005909:Glioblastoma / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D009778:Occipital Lobe; D009837:Oligodendroglioma / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D010296:Parietal Lobe; D011879:Radiotherapy Dosage; D013702:Temporal Lobe; D013788:Thalamus; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D002945:Cisplatin; D005472:Fluorouracil
L'association 5-FU/CDDP/radiothérapie hypofractionnée dans les récidives des astrocytomes et des gliomes malins sustentoriels de l'adulte.