[Average daily values of the isotopic carbon composition in expired air and urea in human urine in normal states and in some endocrine disorders].
Daily average carbon isotope composition of CO2 of expired air and urine urea in patients being in different hormonal-metabolic states was determined. The observations were carried out under conditions of clinic to provide standard diet, and the same daily and food taking regimes. In all persons, a substantial increase enrichment in 12C of CO2 of expired air (by 3-6%) and 13C of urine urea (by 3-5%) relative to carbon of food was revealed. Marked variations in these characteristics in norm, on starvation and in endocrine pathologies were found. A relationship between the carbon isotope composition and the metabolic shifts characterizing the deviations of the studied functional states from norm was established. The changes in the isotope characteristics and their relation to the hormonal-metabolic status of the organism are interpreted in terms of the model for cell fractionation of carbon isotopes proposed earlier.
Ivlev
A A
AA
Kniazev
Iu A
IuA
Logachev
M F
MF
D001944:Breath Tests; D002245:Carbon Dioxide / Q000378:metabolism*; D002247:Carbon Isotopes; D004032:Diet; D004700:Endocrine System Diseases / Q000378:metabolism* / Q000652:urine*; D006801:Humans; D008297:Male; D014508:Urea / Q000652:urine*
D002247:Carbon Isotopes; D002245:Carbon Dioxide; D014508:Urea
Srednesutochnye znacheniia izotopnogo sostava ugleroda CO2 vydykhaemogo vozdukha i mocheviny mochi u cheloveka v norme i pri nekotorykh éndokrinnykh patologiiakh.