title: Urinary gonadotropin peptide in patients with cancer of digestive organs.
abstract: Urinary gonadotropin peptide (UGP) has been measured in gynecological and urological cancers, but its usefulness in the diagnosis of cancers of digestive organs has not been investigated. In this report, UGP was measured by sandwich enzyme immunoassay in 311 patients, including 166 patients with cancers of digestive organs and 43 healthy controls. Positive rates of UGP in various cancers of digestive organs were as follows: biliary tract 61.5%, pancreas 61.5%, esophagus 50.0%, liver 38.7%, colon and rectum 24.2%, and stomach 23.9%. The positive rate of UGP in benign diseases was 8.1%, and most false-positive patients were postmenopausal females. Positive rates of UGP were increased at advanced stages of gastric cancers, and UGP was decreased after tumor resection. From these results, it is suggested that UGP can be used as a tumor marker for the cancers of digestive organs.
authors.affiliation: Department of Internal Medicine, Kanazawa University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Motoo
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: I
authors.initials: I
authors.lastname: Mouri
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: O
authors.initials: O
authors.lastname: Yamakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Satomura
authors.forename: T
authors.initials: T
authors.lastname: Okai
authors.forename: N
authors.initials: N
authors.lastname: Sawabu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000652:urine*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D006063:Chorionic Gonadotropin / Q000032:analysis; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000652:urine*; D003404:Creatinine / Q000097:blood / Q000652:urine; D004067:Digestive System Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery / Q000652:urine*; D005260:Female; D005706:Gallbladder Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery / Q000652:urine*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery / Q000652:urine*; D010446:Peptide Fragments / Q000652:urine*; D012016:Reference Values; D015203:Reproducibility of Results; D012727:Sex Characteristics
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; C063554:urinary gonadotropin fragment; D003404:Creatinine