[Effect of the administration of furosemide on the fluid filtration rate and in pulmonary artery pressure in isolated lungs of rabbits].
To study the possible effects of Furosemide at the lung level, two groups of isolated rabbit lung preparation were studied. An experimental group underwent a pulmonary hydrostatic oedema when the pressure of the left auricle (PAI) was increased from 0.45 +/- 0.74 t0 11.8 +/- 2.9 cm of H2O, with that increase in PAI we obtained an increase of 0.457 +/- 0.51 g/min in FFR (Fluid Filtration Rate), during this stable and sustained oedema, a 2 mg/Kg dosis of Furosemide was injected every 10 minutes and the possible changes in PAP, PAI, PVA, TFL, PaO2, PaCO2 and pH was observed, but no changes were observed in these parameters during the Furosemide infusion, and the same effect was observed in the control group were the preparations were maintained in basal conditions and without oedema. These results suggests that the Furosemide hat not a direct cardio-pulmonary effects, and the only possible effects could be by increasing diuresis at renal level.
Rosales Romero
A M
AM
Instituto de Medicina Experimental, U.C.V.
Curiel Zarraga
C
C
Pluchino
S
S
Tristano
S
S
Sánchez De León
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D005665:Furosemide / Q000008:administration & dosage*; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D011651:Pulmonary Artery / Q000502:physiology*; D011817:Rabbits
D005665:Furosemide
Efecto de la administración de furosemida en la tasa de filtracion de liquido y en la presión de la arteria pulmonar en el pulmón aislado de conejo.