The hyperkeratotic variant of porokeratosis Mibelli is a distinct entity: clinical and ultrastructural evidence.
An isolated case with the hyperkeratotic variant of porokeratosis Mibelli (PM) is reported. The 62-year-old woman developed multiple brown macules with well demarcated large keratotic nodules on both legs. Histopathological studies revealed the presence of a cornoid lamella characteristic of porokeratosis. Ultrastructural investigations revealed dyskeratotic as well as edematous, swollen keratinocytes; autophagocytotic vacuoles were visible. The clinical and ultrastructural peculiarities of the hyperkeratotic variant of PM suggest the possibility of a separate entity.
Schaller
M
M
Department of Dermatology, Ludwig Maximilians University, Munich, Germany.
Korting
H C
HC
Kollmann
M
M
Kind
P
P
D000287:Administration, Topical; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D017499:Porokeratosis / Q000145:classification / Q000188:drug therapy / Q000473:pathology*; D012867:Skin / Q000473:pathology / Q000648:ultrastructure
D003879:Dermatologic Agents