Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
Gueiffier
A
A
Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Montpellier, France.
Lhassani
M
M
Elhakmaoui
A
A
Snoeck
R
R
Andrei
G
G
Chavignon
O
O
Teulade
J C
JC
Kerbal
A
A
Essassi
E M
EM
Debouzy
J C
JC
Witvrouw
M
M
Blache
Y
Y
Balzarini
J
J
De Clercq
E
E
Chapat
J P
JP
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000998:Antiviral Agents; D009705:Nucleosides; D011725:Pyridines; D011743:Pyrimidines; C001439:imidazo(1,2-a)pyridine