Study on in vitro stability of polymerized liposomes.
We studied the stability of liposomes composed of polymerized phospholipid, 1,2-bis-(octadeca-2,4-dienoyl)-sn-glycero-3-phosphocholine (DENPC), to pH changes and the presence of bile salts, monitoring the leakage of 3H-sucrose entrapped in liposomes. The stability of polymerized DENPC-liposomes to acidic media (pH 3.3 and 2), and the presence of bile salts (20 mM), was much higher than that of nonpolymerized DENPC-liposomes and liposomes composed of conventional phospholipids. The stability of polymerized DENPC-liposomes was increased in the presence of carboxymethyl chitin (CM-chitin).
Nishiya
T
T
Artificial Cells & Organs Research Centre, McGill University, Montreal, Quebec, Canada.
Jain
B
B
D001647:Bile Acids and Salts / Q000737:chemistry*; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D011108:Polymers; D013395:Sucrose
C102749:1,2-bis(octadeca-2,4-dienoyl)-glycero-3-phosphocholine; D001647:Bile Acids and Salts; D008081:Liposomes; D010713:Phosphatidylcholines; D011108:Polymers; D002686:Chitin; C044872:O-(carboxymethyl)chitin; D013395:Sucrose