title: [A case of toxoplasmosis with dermatomyositis].
abstract: We report a case of dermatomyositis (DM) in a 15-year-old female with toxoplasmosis after ingestion of raw bovine liver. Facial erythema and cervical lymphadenopathy preceded myalgia and muscle weakness of the extremities. The diagnostic criteria of DM was fulfilled because of symmetrical and proximal dominant muscle weakness, elevation of myogenic enzyme (CPK, GOT, LDH, myoglobin, aldorase), myogenic pattern of electromyogram, skeletal muscle biopsy showing interstitial myositis with mild destruction of muscle fiber, and facial erythema. Immunological findings showed IgG anti-toxoplasma antibody to be 1340 IU/ml and IgM to be 7.0 (Cut off index 0.7), suggesting acute toxoplasmosis. Treatment with prednisolone for DM and acetylspiramycin for toxoplasmosis was successful. Toxoplasmosis should be considered as a possibility in patients with myositis.
authors.affiliation: Department of General Medicine, Kyushu University.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
authors.forename: J
authors.initials: J
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Fujisaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tani
authors.forename: S
authors.initials: S
authors.lastname: Kashiwagi
authors.forename: S
authors.initials: S
authors.lastname: Yamaga
mesh_terms: D000293:Adolescent; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000097:blood; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D011239:Prednisolone / Q000627:therapeutic use; D015572:Spiramycin / Q000031:analogs & derivatives / Q000627:therapeutic use; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000913:Antibodies, Protozoan; D007075:Immunoglobulin M; C033163:acetylspiramycin; D015572:Spiramycin; D011239:Prednisolone