Nifedipine reduces postexercise proteinuria in young volunteers.
Previous studies have demonstrated that it is possible to prevent postexercise proteinuria with angiotensin-converting enzyme inhibitors. To determine whether calcium antagonists have the same effect, 40 young healthy volunteers underwent maximal aerobic exercise with and without nifedipine 10 mg per os 1 h before the first or second trial. Urinary excretion of albumin (UAE), transferrin (UTE) and alpha 1-microglobulin (UME) were examined before and after each trial. UAE, UTE and UME were significantly increased after exercise. Nifedipine significantly decreased UAE (p = 0.001) and UTE (p = 0.02) after exercise, and slightly decreased the maximal work load and the basal excretion of albumin. UME was unchanged. Therefore, the results of this study demonstrate that nifedipine administration before exercise significantly reduces postexercise proteinuria.
Cosenzi
A
A
Institute of Clinical Medicine University of Trieste, Italy.
Carraro
M
M
Sacerdote
A
A
Bocin
E
E
Molino
R
R
Benazzi
T
T
Artero
M L
ML
Faccini
L
L
Bellini
G
G
D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011507:Proteinuria / Q000188:drug therapy*; D012016:Reference Values
D002121:Calcium Channel Blockers; D009543:Nifedipine