Bacterial transferrin and lactoferrin receptors.
Pathogenic members of the Neisseriaceae and Pasteurellaceae express outer-membrane receptor proteins involved in the direct assimilation of iron from the host glycoproteins transferrin and lactoferrin. The critical requirement of iron for growth suggests that this function is an important component of colonization and infection. A model describing this novel process is presented.
Gray-Owen
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SD
Dept of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Alberta, Canada. sdgrayow@acs.ucalgary.ca
Schryvers
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AB
D000595:Amino Acid Sequence; D001692:Biological Transport; D006801:Humans; D007501:Iron / Q000378:metabolism; D007781:Lactoferrin / Q000378:metabolism; D008969:Molecular Sequence Data; D009343:Neisseria / Q000472:pathogenicity*; D015661:Pasteurellaceae / Q000472:pathogenicity*; D011956:Receptors, Cell Surface / Q000378:metabolism; D011990:Receptors, Transferrin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D014168:Transferrin; C038340:lactoferrin receptors; D007501:Iron; D007781:Lactoferrin