Quantitative cancer assessment for vinyl chloride: indications of early-life sensitivity.
Complementary sources of information are analyzed to characterize the early-life cancer risk from inhaling vinyl chloride. A study of partial-lifetime exposures suggests that the lifetime cancer risk depends on age at exposure, with higher lifetime risks attributable to exposures at younger ages. Studies of newborn animal exposures further demonstrate that a brief exposure in newborns can, by the end of life, induce a higher incidence of tumors compared to long-term exposure occurring later in life, including tumor types not induced by exposure later in life. An empirical, quantitative approach is used to model early-life sensitivity to inhaled vinyl chloride, supplementing conventional approaches for estimating the increased cancer risk from lifetime exposure. A single estimate is not presumed to apply to the entire population; instead, the new approach makes distinctions about the cancer risks for different population segments. This assessment shows one way such information might be analyzed, presented, and used to assess actual exposure situations.
Cogliano
V J
VJ
United States Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460, USA.
Hiatt
G F
GF
Den
A
A
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D002273:Carcinogens / Q000633:toxicity*; D004198:Disease Susceptibility; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D014752:Vinyl Chloride / Q000633:toxicity*
D002273:Carcinogens; D014752:Vinyl Chloride