title: [Cardiomyocyte cytoskeleton in dilated cardiomyopathy and ischemic heart disease].
abstract: Summary. Vinculin, the protein of cardiomyocyte cytoskeleton in the myocardium of patients with a dilated cardiomyopathy and ischemic heart disease, was revealed by means of monoclonal antibodies and by a method of indirect immunofluorescence. Cytoskeleton of patients with dilated cardiomyopathy is disorganized, hypertrophic and contains greater amounts of vinculin than cytoskeleton of normal cardiomyocytes. This most likely negatively influences cell contractile capacity. The vinculin content was also higher in cardiomyocyte cytoskeleton of patients with ischemic heart disease but at a less degree than in patients with dilated cardiomyopathy.
authors.forename: L V
authors.initials: LV
authors.lastname: Beletskaia
authors.forename: L B
authors.initials: LB
authors.lastname: Zhbanova
authors.forename: V A
authors.initials: VA
authors.lastname: Zaĭdenov
authors.forename: L G
authors.initials: LG
authors.lastname: Kurenkova
authors.forename: E I
authors.initials: EI
authors.lastname: Riaboshtanova
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal; D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000473:pathology*; D003599:Cytoskeleton / Q000737:chemistry / Q000648:ultrastructure*; D019084:Fluorescent Antibody Technique, Indirect; D000882:Haplorhini; D016027:Heart Transplantation / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D051381:Rats; D013552:Swine; D014184:Transplantation, Homologous; D016596:Vinculin / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D016596:Vinculin
vernacular_title: Ul'trastruktura mezhmitokhondrial'nykh kontaktov kardiomiotsitov cheloveka pri alkogol'noĭ kardiomiopatii i ischemicheskoĭ bolezni serdtsa.