title: The application of transit dosimetry to precision radiotherapy.
abstract: A method of using electronic portal imaging (EPI) for transit dosimetry is described. In this method, a portal image of the treatment field is first aligned with a digitally reconstructed radiograph (DRR) to geometrically relate the computed tomography (CT) scan, used to generate the DRR, with the EPI. Then the EPI is corrected for scatter within the patient to yield a map of primary fluence striking the detector. This is backprojected through the planning CT data set to yield a distribution of primary fluence within the patient. This distribution is then convolved with dose deposition kemels to yield a map of dose delivery within the patient. Such a distribution may be compared with the dose distribution resulting from the original treatment plan in order to evaluate the adequacy of the treatment. This method has been evaluated using a humanoid phantom. We find the transit dosimetry relative dose distribution when compared with film and thermoluminescent dosimeter (TLD) measurements and compared with our planning system to agree within 2% in the pelvic region of a humanoid phantom.
authors.affiliation: Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
authors.forename: V N
authors.initials: VN
authors.lastname: Hansen
authors.forename: P M
authors.initials: PM
authors.lastname: Evans
authors.forename: W
authors.initials: W
authors.lastname: Swindell
mesh_terms: D004867:Equipment Design; D006801:Humans; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D011878:Radiotherapy / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D011879:Radiotherapy Dosage; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D014057:Tomography, X-Ray Computed