title: Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
abstract: The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
authors.affiliation: Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Gueiffier
authors.forename: M
authors.initials: M
authors.lastname: Lhassani
authors.forename: A
authors.initials: A
authors.lastname: Elhakmaoui
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: O
authors.initials: O
authors.lastname: Chavignon
authors.forename: J C
authors.initials: JC
authors.lastname: Teulade
authors.forename: A
authors.initials: A
authors.lastname: Kerbal
authors.forename: E M
authors.initials: EM
authors.lastname: Essassi
authors.forename: J C
authors.initials: JC
authors.lastname: Debouzy
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw
authors.forename: Y
authors.initials: Y
authors.lastname: Blache
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J P
authors.initials: JP
authors.lastname: Chapat
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D011725:Pyridines; D011743:Pyrimidines; C001439:imidazo(1,2-a)pyridine