[Effects of gestrinone on experimental endometriosis in rabbits].
OBJECTIVE
To study the therapeutic effects of gestrinone on experimental endometriosis in rabbits.


METHODS
Mature female rabbits were laparotomized under sterile condition and three or four segments of endometrium (7 mm x 7 mm) were sutured to the mesentery of uterus. Seven weeks after operation these animals were divided into 5 groups: control; treated with danazol 20mg/kg; gestrinone 0.06, 0.12, 0.24 mg/kg for 4 weeks respectively. At the end treatment they were laparotomized again. The ectopic endometrial implants were weighted and their morphologic features were analysed quantitatively by semi-automatic image analysis system, meanwhile serum follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone (P) concentrations were determined by radioimmunoassay.


RESULTS
Decreased weight and atrophy of ectopic endometrial implants were shown in all experimental groups, except for control and 0.06 mg/kg gestrinone treated-group. In 0.12, 0.24 mg/kg gestrinone treated-group, except for P serum FSH, LH and E2, concentrations decreased significantly. The degree of inhibition on ectopic lesions of 0.12 mg gestrinone group was similar to that of danazol group.


CONCLUSIONS
Gestrinone inhibits the growth of ectopic endometrial implants in a dose-dependent manner and showed a significant therapeutic effects on experimental endometriosis in rabbits.
Giu
Y
Y
Institute of Integrated Traditional Chinese and Western Medicine, Shenzhen Red Cross Hospital, Shenzhen.
Huang
S
S
Wu
X
X
D000818:Animals; D003613:Danazol / Q000627:therapeutic use; D004715:Endometriosis / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D005867:Gestrinone / Q000627:therapeutic use*; D045167:Progesterone Congeners / Q000627:therapeutic use*; D011817:Rabbits; D014591:Uterine Diseases / Q000188:drug therapy*
D004965:Estrogen Antagonists; D045167:Progesterone Congeners; D005867:Gestrinone; D003613:Danazol