title: Hemodiafiltration in pentobarbital poisoning.
abstract: We report the use of continuous venovenous hemodiafiltration (CVVHD) in a case of massive intentional ingestion of pentobarbital associated with severe coma and hypotension. Despite a poor hemodynamic state, toxic epuration (15% of drug ingested) was obtained. However, death occurred 7 hr after the end of treatment. This report suggests that CVVHD can be effective in the treatment of massive pentobarbital intoxication.
authors.affiliation: Department of Intensive Care Medicine, Toxicology, and Nephrology, Hôtel-Dieu Hospital, Nantes, France.
authors.forename: E
authors.initials: E
authors.lastname: Bironneau
authors.forename: F
authors.initials: F
authors.lastname: Garrec
authors.forename: M F
authors.initials: MF
authors.lastname: Kergueris
authors.forename: A
authors.initials: A
authors.lastname: Testa
authors.forename: F
authors.initials: F
authors.lastname: Nicolas
mesh_terms: D000208:Acute Disease; D000328:Adult; D017809:Fatal Outcome; D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D008297:Male; D010424:Pentobarbital / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D013405:Suicide; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D010424:Pentobarbital