title: [Mutagenic effects of bimolane].
abstract: OBJECTIVE
  To study the genotoxicity of bimolane.
  
  
  METHODS
  Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test.
  
  
  RESULTS
  Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (P < 0.01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150 micrograms/plate in Ames test.
  
  
  CONCLUSIONS
  Bimolane is a kind of genotoxic compound.
authors.affiliation: Jiangsu Institute of Cancer Research, Nanjing, China.
authors.forename: S Q
authors.initials: SQ
authors.lastname: Chen
authors.forename: K X
authors.initials: KX
authors.lastname: Xue
authors.forename: J Z
authors.initials: JZ
authors.lastname: Wu
authors.forename: G J
authors.initials: GJ
authors.lastname: Ma
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002869:Chromosome Aberrations; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011929:Razoxane / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D009153:Mutagens; C031186:bimolane; D011929:Razoxane