Harmful effects of MSG on function of hypothalamus-pituitary-target gland system.
It has been demonstrated that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus (AN) of the hypothalamus. The present study shows that fat was accumulated in the abdomen of male rats treated with MSG; weights of the body, pituitary and testis were lower; beta-EP content in hypothalamus decreased while L.EnK content increased; serum LH, FSH, TSH, GH and TS levels all decreased in varying degrees while serum PRL level significantly increased. The cAMP content lowered in pituitary, but nor in testes; clear histological changes occurred in testicular tissue; Se-GSH-Px activity in both testis and adrenal gland lowered while LPO level significantly increased. Both Se-GSH-Px activity and LPO level in liver increased. These results indicate that MSG is harmful to the function of the hypothalamus-pituitary-target system of neonatal rats.
Gong
S L
SL
Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, China.
Xia
F Q
FQ
Wei
J
J
Li
X Y
XY
Sun
T H
TH
Lu
Z
Z
Liu
S Z
SZ
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D012970:Sodium Glutamate