title: [Antibiotic-impregnated prostheses: eclectic indications].
abstract: OBJECTIVE
  Infection is a major complication in vascular stents. Stents impregnated with gelatine and dipped in Rifampicin have been shown to resist methicillin-resistant Staphylococcus aureus in both animal experiments and in man. It has been suggested that all aorto-ilio-femoral stents should be treated. To evaluate this method, we reassessed all stent infections observed in our patients who had undergone revascularization of the lower limbs from January 1985 to 1994. We excluded stents implanted for ruptured aneurysms or implanted in patients with a past history of local infection on vascular stents.
  
  
  RESULTS
  The rate of septic complications observed during the first year was 1% for all patients in the series, 0% for aorto-aortic and aorto-biiliac stents and 0.7% for aorto- bifemoral stents. These rates are similar to those reported in the multicentric study directed by Goeau Brissonière using antibiotic impregnated stents. The extra cost involved in using such stents for aorto-ilio-femoral revascularization was estimated in this series at 2,180,000 Francs. The costs resulting from the three infections was estimated at 960,000 Francs.
  
  
  CONCLUSIONS
  Based on the findings in this series, antibiotic impregnated stents should be indicated only in selected patients due to the extra cost: past history of local infection, ruptured aneurysms, femoro-tibial stents, cross or axillo-femoral revascularization for which the rate of stent infection is 6.3 - 3.2 and 1.4%, immunodeficient patients, multiple reoperations, post-irradiation arteritis and situations known to involve major risk of infection.
authors.affiliation: Service de Chirurgie Vasculaire, Hôpital Henri Mondor, Créteil.
authors.forename: D
authors.initials: D
authors.lastname: Melliere
authors.forename: S
authors.initials: S
authors.lastname: Zaouche
authors.forename: J P
authors.initials: JP
authors.lastname: Becquemin
authors.forename: P
authors.initials: P
authors.lastname: Desgranges
authors.forename: A
authors.initials: A
authors.lastname: Cavillon
authors.forename: J
authors.initials: J
authors.lastname: Tankovic
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D012189:Retrospective Studies; D012293:Rifampin / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects*; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D012293:Rifampin
vernacular_title: Prothèses imprégnées d'antibiotiques: des indications éclectiques.