title: [The treatability of refractory or resistant hypertension by personalized antihypertensive chronotherapy based on ambulatory monitoring of the arterial pressure].
abstract: The present paper is aimed at detecting whether the combination of ambulatory blood pressure monitoring (ABPM) and antihypertensive chronotherapy can be usefully exploited in the treatment of hypertension which appears to be rebel or resistant to pharmacological administration. The study was carried out in 28 hypertensive patients (15 men and 13 women, 45 +/- 10 years old), rebel (10 cases) or resistant (8 cases) to a conventional antihypertensive therapy. The ABPM was performed weekly in order to see when the eventual patient was cured by the therapy which was synchronized to the "relative hypertensive peak" of the antimeridian, postmeridian and nocturnal part of the day. The actuarial analysis documented that at the end of the sixth week no case remained rebel or resistant to the antihypertensive chronotherapy, suggesting that the combination of the ABPM with the chronotherapeutical treatment is highly recommended in presence of apparently refractory cases of hypertension.
authors.affiliation: Semeiotica e Metodologia Medica, Università La Sapienza, Roma.
authors.forename: P
authors.initials: P
authors.lastname: Cugini
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D001794:Blood Pressure / Q000187:drug effects; D015924:Blood Pressure Monitors / Q000706:statistics & numerical data; D002940:Circadian Rhythm / Q000187:drug effects*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents
vernacular_title: Trattabilità dell'ipertensione ribelle o resistente mediante cronoterapia antipertensiva personalizzata basata sul monitoraggio ambulatorio della pressione arteriosa.