[Clinico-pathological predictive indicators in squamous cell carcinoma of the head and neck].
The significance of prognostic factors that may predict the clinical outcome of patients with head and neck cancer was discussed. Many indicators can be grouped into three categories, patient factors, tumor factors and treatment factors. The most significant indicator of prognosis seems to be pathological nodal stage. Factors such as clinical stage, resectability, and depth of invasion may also affect the patient outcome. Recent research development has revealed biological phenotypes of cancer cells to predict the effect of cancer treatment and the clinical course in head and neck cancer. Possible predictive indicators include DNA ploidy, Tpot, EGFR and cyclin D1. C erbB2 and p53 may not predict the survival of patients with head and neck cancer.
Horiuchi
M
M
Department of Otolaryngology, Tokai University School of Medicine, Japan.
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D019938:Cyclin D1; D016213:Cyclins / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D015513:Oncogene Proteins / Q000378:metabolism; D011003:Ploidies; D011379:Prognosis
D016213:Cyclins; D004273:DNA, Neoplasm; D015513:Oncogene Proteins; D019938:Cyclin D1; D066246:ErbB Receptors