Effects on the pharmacokinetics and pharmacodynamics in the elderly of coadministering ramipril with water, apple juice, and applesauce.
Lee
I D
ID
Clinical Research and New Drug Development, Hoechst-Roussel Pharmaceuticals Inc., Somerville, New Jersey, USA.
Hunt
T L
TL
Bradley
C R
CR
Copp
C
C
Griffiths
L
L
Brobst-Kromer
J
J
D000284:Administration, Oral; D000368:Aged; D000375:Aging / Q000378:metabolism; D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002214:Capsules; D018592:Cross-Over Studies; D005638:Fruit; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D017257:Ramipril / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D013810:Therapeutic Equivalency; D014867:Water / Q000008:administration & dosage
D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D002214:Capsules; D014867:Water; C052549:ramiprilat; D017257:Ramipril