Human DNA topoisomerase II: biochemistry and role in chemotherapy resistance (review).
Recently, it has been discovered that DNA topoisomerases are the target of many anti-cancer drugs which were already widely used in the clinic. Using the latest molecular biological techniques much has been learned about the function of DNA topoisomerases in normal cells and in cancer cells, and about how anticancer drugs inhibit these enzymes. In this review we present an overview of the function of human type II DNA topoisomerases, how they are inhibited by certain drugs and on how cancer cells may become resistant to these drugs.
Withoff
S
S
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
De Jong
S
S
De Vries
E G
EG
Mulder
N H
NH
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004250:DNA Topoisomerases, Type II / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D017354:Point Mutation; D011401:Promoter Regions, Genetic; D017510:Protein Folding; D017384:Sequence Deletion; D014158:Transcription, Genetic
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D004250:DNA Topoisomerases, Type II