title: Time-relationship between bone growth and increment of bone mineral content in growing rats.
abstract: The aim of the study was to describe the time-relationship between the growth rate of the rat tibia and the increase rate of its mineral content. Appositional and endochondral bone growth rates were derived from sequential X-rays measurements of tibial widening and lengthening, respectively; the increase rate of bone mineral content was derived from sequential photon absorptiometry measurements of the proximal tibio-fibular site. The time-relationship of appositional growth rate and endochondral growth rate versus bone mineral content increase rate was mathematically described. The results allow a better understanding of the time-course of two distinct features of bone growth: increase in size and increase in mineral content.
authors.affiliation: Department of Pharmacology, University of Milano.
authors.forename: G
authors.initials: G
authors.lastname: Reina
authors.forename: A
authors.initials: A
authors.lastname: Rubinacci
authors.forename: G L
authors.initials: GL
authors.lastname: Moro
authors.forename: L
authors.initials: L
authors.lastname: Moro
authors.forename: A
authors.initials: A
authors.lastname: Pecile
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology*; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D013977:Tibia / Q000033:anatomy & histology / Q000502:physiology; D013997:Time Factors