On the synthesis of pyridazomycin congeners. Part 2: L-alpha-Amino acids bearing a terminal azinium or diazinium system.
The synthesis of a variety of novel compounds structurally related to the antimicrobial natural product pyridazomycin via alkylation of appropriate azine and diazine derivatives is reported. Based on the results of preliminary antimicrobial tests the dependence of antimicrobial activity from several structural features of pyridazomycin is discussed.
Easmon
J
J
Institute of Pharmaceutical Chemistry, Leopold-Franzens University, Innsbruck, Austria.
Heinisch
G
G
Holzer
W
W
Matuszczak
B
B
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011724:Pyridazines / Q000737:chemistry / Q000494:pharmacology
D000596:Amino Acids; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011724:Pyridazines; C056340:pyridazomycin