Contrast enhancement with Gd-EOB-DTPA in MR imaging of hepatocellular carcinoma in mice: a comparison with superparamagnetic iron oxide.
The purpose of this study was to evaluate the ability of the new liver-specific magnetic resonance contrast agent gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) to detect hepatocellular carcinoma (HCC). Seventeen mice with 66 chemically induced HCCs underwent magnetic resonance imaging with both Gd-EOB-DTPA (30 mumol/kg) and superparamagnetic iron oxide (SPIO; 10 mumol/kg). After enhancement, lesion-to-liver contrast-to-noise ratios (CNRs) of 47 detected HCCs increased negatively from 3.7 +/- 10.7 (mean +/- SD) to -55.1 +/- 25.8 with Gd-EOB-DTPA (P < .001) and increased positively from 10.4 +/- 10.4 to 26.1 +/- 16.3 with SPIO (P < .001). The improvement of CNR after administration of SPIO was less in smaller lesions (< 4 mm), whereas that after administration of Gd-EOB-DTPA was independent of lesion size. However, Gd-EOB-DTPA positively enhanced four HCCs (8.5%), both highly differentiated (grade 1) and moderately differentiated (grade 2). Gd-EOB-DTPA allows the conspicuous detection of small HCCs; however, moderately differentiated HCCs occasionally may be positively enhanced.
Fujita
M
M
Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Yamamoto
R
R
Fritz-Zieroth
B
B
Yamanaka
T
T
Takahashi
M
M
Miyazawa
T
T
Tatsuta
M
M
Terada
N
N
Hosomi
N
N
Inoue
E
E
Kuroda
C
C
D000818:Animals; D003287:Contrast Media; D052203:Ferrosoferric Oxide; D019786:Gadolinium DTPA; D007089:Image Enhancement; D007501:Iron; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D012680:Sensitivity and Specificity
D003287:Contrast Media; D009942:Organometallic Compounds; D010087:Oxides; C073590:gadolinium ethoxybenzyl DTPA; D004369:Pentetic Acid; D007501:Iron; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide