title: Micronucleoli in lymphocytes of the peripheral blood of patients suffering from chronic lymphocytic leukemia (B type).
abstract: The incidence of micronucleoli was investigated in lymphocytes of the peripheral blood of patients suffering from B chronic lymphocytic leukemia (B CLL). The cytostatic monochemotherapy with chlorambucil apparently produced in these cells an increased incidence of micronucleoli which are known to represent the morphological expression of the inhibition of the nucleolar ribonucleic acid (RNA) transcription. Similarly, the percentage of lymphocytes with micronucleoli was increased after the cytostatic therapy disregarding whether such nucleoli were present in these cells as the only nucleolar type or in addition to other nucleolar types as satellite nucleoli.
authors.affiliation: Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Smetana
authors.forename: H
authors.initials: H
authors.lastname: Subrtová
authors.forename: I
authors.initials: I
authors.lastname: Jirásková
authors.forename: L
authors.initials: L
authors.lastname: Rosa
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology*; D008214:Lymphocytes / Q000648:ultrastructure*; D048629:Micronuclei, Chromosome-Defective / Q000648:ultrastructure*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil