Interaction of glycyl-phenylalanine with carbohydrates as a model of N-terminal glycation of proteins.
Glycation is thought to be a factor in the development of cataract in elderly and diabetic patients. In this report, we describe our initial investigations on the reaction of the dipeptide glycyl-phenylalanine (GF) with different carbonyl compounds as a model of protein glycation. The results obtained demonstrate that the interaction of GF with carbohydrates has features in common with glycation of lens membrane proteins and lens crystallins.
Argirov
O K
OK
Department of Organic Chemistry, University of Plovdiv, Bulgaria.
Kerina
I I
II
D001205:Ascorbic Acid / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D005632:Fructose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D014994:Xylose / Q000737:chemistry
D002241:Carbohydrates; D004151:Dipeptides; D011506:Proteins; D005632:Fructose; D010649:Phenylalanine; C029660:glycylphenylalanine; D014994:Xylose; D005947:Glucose; D001205:Ascorbic Acid