title: The role of growth factors in preimplantation development.
abstract: It has become clear that the mammalian embryo participates in a complex dialogue with the maternal physiology. The language of the dialogue is growth factor signalling. The embryo expresses receptors for insulin, IGFs, GH, EGF and cytokines including LIF, and CSFs; whilst ligands are secreted by the supporting tissues of the oviduct and uterus, and in some cases, the embryo itself. In the preimplantation period when the embryo is travelling to the uterus and passing through its first differentiation, these ligands affect embryonic physiology, apparently in ways that optimise developmental potential and synchronise embryonic and maternal physiologies. It is not yet clear in most cases whether this is by autocrine, paracrine or endocrine mode. In the crucial peri-implantation phase the embryo is preparing to invade the maternal system for which extensive uterine remodelling is necessary. A model is proposed in which a cascade of growth factor activities, orchestrated by the ovarian steroid patterns, choreographs the biochemical players (ECM proteinases and their inhibitors) which initiate this activity.
authors.affiliation: Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia.
authors.forename: P L
authors.initials: PL
authors.lastname: Kaye
authors.forename: M B
authors.initials: MB
authors.lastname: Harvey
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D010064:Embryo Implantation / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D011247:Pregnancy; D011972:Receptor, Insulin / Q000502:physiology; D017451:Receptors, Somatomedin / Q000502:physiology; D013002:Somatomedins / Q000502:physiology
chemical_list: D006133:Growth Substances; D007328:Insulin; D017451:Receptors, Somatomedin; D013002:Somatomedins; D011972:Receptor, Insulin