title: The mydriatic effect of topical glycopyrrolate.
abstract: BACKGROUND
  Glycopyrrolate, an anticholinergic agent that does not cross the blood-brain barrier, has several indications, but its mydriatic effect has never been tested. This study was carried out in order to compare the mydriatic effect of glycopyrrolate 0.5% to that of atropine sulfate 1%.
  
  
  METHODS
  Glycopyrrolate 0.5% and atropine 1.0% were instilled separately in the eyes of albino rabbits. Pupil diameter and intra-ocular pressure were monitored.
  
  
  RESULTS
  Mydriasis was noted within 5 min of glycopyrrolate instillation, reached near-maximal level at 15 min and persisted for 1 week. Glycopyrrolate 0.5% showed a faster, stronger and more persistent mydriatic effect than atropine 1.0%. Administration of glycopyrrolate 0.5% solution b.i.d. for 1 week did not affect intra-ocular pressure or produce any adverse reaction.
  
  
  CONCLUSIONS
  Glycopyrrolate solution has the potential to deliver an ocular anticholinergic effect without causing associated central anticholinergic hazards.
authors.affiliation: Department of Ophthalmology, Ichilov Hospital, Tel-Aviv, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Varssano
authors.forename: S
authors.initials: S
authors.lastname: Rothman
authors.forename: K
authors.initials: K
authors.lastname: Haas
authors.forename: M
authors.initials: M
authors.lastname: Lazar
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007429:Intraocular Pressure; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits
chemical_list: D018727:Muscarinic Antagonists; D009883:Ophthalmic Solutions; D001285:Atropine; D006024:Glycopyrrolate