title: Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RA(low)CD45RO(low) T cells in newborn blood.
abstract: Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RA(low)CD45RO(low) T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.
authors.affiliation: Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0526, USA.
authors.forename: S
authors.initials: S
authors.lastname: Chheda
authors.forename: K H
authors.initials: KH
authors.lastname: Palkowetz
authors.forename: D K
authors.initials: DK
authors.lastname: Rassin
authors.forename: A S
authors.initials: AS
authors.lastname: Goldman
mesh_terms: D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005312:Fetal Blood / Q000166:cytology; D005434:Flow Cytometry; D006801:Humans; D007231:Infant, Newborn; D017493:Leukocyte Common Antigens / Q000096:biosynthesis* / Q000097:blood / Q000737:chemistry; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D017493:Leukocyte Common Antigens