The influence of pefloxacine on experimental adriamycin-induced nephrotic syndrome in rats.
Initial reports on antiproteinuric effect of pefloxacine in small groups of patients with minimal-change nephropathy (MCN) and focal and segmental glomerulosclerosis (FSGS) have not been confirmed in other papers. To assess its antiproteinuric effect in experimental animals we administered pefloxacine to rats with adriamycin nephropathy showing morphological changes resembling human minimal-change disease or focal segmental glomerulosclerosis, and clinically with full-blown nephrotic syndrome. Pefloxacine treatment was at least partially effective in preventing further increase of proteinuria in rats with adriamycin nephropathy. The mechanism of this effect remains unclear and deserves further studies concentrating on the glomerular cytokine network and glomerular production of reactive oxygen species.
Zima
T
T
First Institute of Medical Chemistry and Biochemistry, Faculty of Medicine I, Charles University, Prague, Czech Republic.
Tesar
V
V
Rychlík
I
I
Nĕmecek
K
K
Poledne
R
R
Tĕmínová
J
J
Stípek
S
S
Merta
M
M
D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin; D004353:Drug Evaluation, Preclinical; D005260:Female; D009404:Nephrotic Syndrome / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D015366:Pefloxacin / Q000627:therapeutic use*; D011507:Proteinuria / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D015366:Pefloxacin; D004317:Doxorubicin