The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice.
Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.
Ulugöl
A
A
Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Karadag
H
H
Dökmeci
D
D
Dökmeci
I
I
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011969:Receptors, Histamine H1 / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*; D012640:Seizures / Q000517:prevention & control; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D003189:p-Methoxy-N-methylphenethylamine