title: Life-threatening cardiovascular consequences of anger in patients with coronary heart disease.
abstract: Anger is the affective state most commonly associated with myocardial ischemia and life-threatening arrhythmias. The scope of the problem is sizeable-at least 36,000 (2.4% of 1.5 million) heart attacks are precipitated annually in the United States by anger. The lethal cardiovascular consequences in ischemic heart disease are attributable to the unique physiology of this state, which activates high-gain central neurocircuitry and the sympathetic nervous system, leading to acute sinus tachycardia, hypertension, impaired myocardial perfusion, and a high degree of cardiac electrical instability. Exciting new tools have emerged from the fields of epidemiology, behavioral medicine, and cardiovascular physiology that offer considerable promise in accelerating our understanding of the pathophysiology of anger and in developing means to sever the link between anger and its life-threatening consequences.
authors.affiliation: Institute for Prevention of Cardiovascular Disease, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Verrier
authors.forename: M A
authors.initials: MA
authors.lastname: Mittleman
mesh_terms: D000786:Anger / Q000502:physiology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000523:psychology; D001341:Autonomic Nervous System / Q000503:physiopathology; D003327:Coronary Disease / Q000503:physiopathology / Q000523:psychology*; D004558:Electric Stimulation; D006329:Heart Conduction System / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000523:psychology; D013315:Stress, Psychological / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology