title: Immunosuppressive cyclolignans.
abstract: The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.
authors.affiliation: Laboratorio de Química, Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gordaliza
authors.forename: G T
authors.initials: GT
authors.lastname: Faircloth
authors.forename: M A
authors.initials: MA
authors.lastname: Castro
authors.forename: J M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: M L
authors.initials: ML
authors.lastname: López-Vázquez
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017705:Lignans / Q000138:chemical synthesis / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D013154:Spleen / Q000166:cytology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D017705:Lignans