[Mutagenic effects of bimolane].
OBJECTIVE
To study the genotoxicity of bimolane.


METHODS
Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test.


RESULTS
Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (P < 0.01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150 micrograms/plate in Ames test.


CONCLUSIONS
Bimolane is a kind of genotoxic compound.
Chen
S Q
SQ
Jiangsu Institute of Cancer Research, Nanjing, China.
Xue
K X
KX
Wu
J Z
JZ
Ma
G J
GJ
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002869:Chromosome Aberrations; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011929:Razoxane / Q000031:analogs & derivatives* / Q000633:toxicity
D000970:Antineoplastic Agents; D009153:Mutagens; C031186:bimolane; D011929:Razoxane