Pulmonary capillary pressure during exercise in horses.
The object of this study was to relate pulmonary capillary pressure to arterial and wedge pressures during exercise. Pulmonary vascular pressures were measured in six standardbred horses exercising at speeds equivalent to 75, 90, and 100% of maximal heart rate. Vascular pressures were measured with transducer-tip catheters and expressed relative to esophageal pressure. Pulmonary capillary pressure was estimated by the arterial-occlusion technique modified for exercise. Mean pulmonary arterial, capillary and wedge pressures increased from 30.5 +/- 6.3, 17.8 +/- 4.3, and 13.4 +/- 1.6 mmHg, respectively, at rest, to 70.5 +/- 5.2, 42.1 +/- 5.3, and 38.4 +/- 5.6 mmHg, respectively, at maximal exercise. The largest part of the increase occurred during the first level of exertion. With exercise, the pressure across the lung barely doubled at a time when the cardiac output would have increased at least fivefold. Thus the absolute resistance in both pre- and postcapillary segments must have decreased. The capillary and wedge pressures rose similarly, whereas the difference between them did not change with exertion. The fractional resistance of the precapillary segment increased with exercise. The postcapillary resistance, initially 28% of the total pulmonary vascular resistance, fell to 9% at maximal exercise. The rise (to approximately 45 mmHg) in pulmonary capillary pressure with exertion is consistent with an increase in transvascular filtration.
Sinha
A K
AK
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca 14853, New York, USA.
Gleed
R D
RD
Hakim
T S
TS
Dobson
A
A
Shannon
K J
KJ
D000818:Animals; D002196:Capillaries / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006736:Horses; D010805:Physical Conditioning, Animal; D011312:Pressure; D011652:Pulmonary Circulation / Q000502:physiology*; D013997:Time Factors