Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT.
Fifty seven patients with secondary lymphedema of the upper limb after previous treatment for breast cancer were treated for 3 months with an extract of Ruscus + Hesperidin Methyl Chalcone (CYCLO 3 FORT) or placebo according to a double-blind protocol in the context of a controlled clinical trial. All patients also underwent manual lymphatic drainage twice a week for at least one month. With CYCLO 3 FORT, the reduction in volume of arm edema, the main assessment criteria, was 12.9% after 3 months of treatment as compared with a placebo (p=0.009). Decreased edema tended to be more marked in the forearm compared with the upper arm where excess fat deposition seemed to dominate over excess fluid accumulation. CYCLO 3 FORT was well tolerated with minimal adverse reaction.
Cluzan
R V
RV
Unité de Lymphologie, Hôpital Cognacq-Jay, Paris, France.
Alliot
F
F
Ghabboun
S
S
Pascot
M
M
D000328:Adult; D001132:Arm / Q000473:pathology; D001943:Breast Neoplasms / Q000628:therapy; D004311:Double-Blind Method; D004322:Drainage / Q000379:methods; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010936:Plant Extracts / Q000627:therapeutic use*; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*
D010936:Plant Extracts; D014665:Vasodilator Agents; C013343:cyclo 3