Residues of dimetridazole in eggs after treatment of laying hens.
Laying hens were dosed orally with dimetridazole (DMZ) (50 and 250 mg/kg) for 3 days or intramuscularly (50 mg/kg), also for 3 days, and the residues were determined by liquid chromatography in albumen and yolk. The sensitivity of the whole procedure was 2 ng/g. The drug was excreted preferentially into the yolk (about 57% of the total) and the elimination period lasted for 4-6 days after treatment.
Posyniak
A
A
Department of Pharmacology and Toxicology, National Veterinary Research Institute, Poland.
Semeniuk
S
S
Zmudzki
J
J
Niedzielska
J
J
Biernacki
B
B
D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D002645:Chickens / Q000378:metabolism*; D002853:Chromatography, Liquid / Q000379:methods / Q000662:veterinary; D003048:Coccidiosis / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D004131:Dimetridazole / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis* / Q000378:metabolism; D004529:Egg White / Q000032:analysis; D004530:Egg Yolk / Q000737:chemistry; D004531:Eggs / Q000032:analysis*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D011044:Poland / Q000453:epidemiology; D011201:Poultry Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D011528:Protozoan Infections / Q000453:epidemiology / Q000517:prevention & control; D011529:Protozoan Infections, Animal; D011897:Random Allocation
D000981:Antiprotozoal Agents; D004131:Dimetridazole