Vascular risk factors for atherosclerotic plaque progression in carotid artery.
Two-dimensional ultrasound is a widely used technique for the clinical assessment of carotid atherosclerosis. We measured volumes of atherosclerotic plaques in carotid arteries in 70 patients with a newly developed and tested three-dimensional ultrasound method over a period of twelve months to determine the relation between progression or regression of plaque volume and vascular risk factors. In multiple regression analysis of age, size, smoking, total cholesterol, HDL-cholesterol, HDL/total cholesterol ratio, LDL-cholesterol, triglycerides, HbA1, diastolic and systolic blood pressure, the strongest predictor of plaque progression (p < 0.01) was diastolic blood pressure, diabetes came next (p < 0.05). The optimal adjustment of all risk factors showed a significant influence on plaque progression (r: 0.76).
Delcker
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Department of Neurology, University of Essen, Germany.
Diener
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HC
Wilhelm
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H
D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D001794:Blood Pressure; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D002342:Carotid Artery, External / Q000000981:diagnostic imaging; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D002784:Cholesterol / Q000097:blood; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography
D014280:Triglycerides; D002784:Cholesterol