[The influence of retinol, tocopherol and cimetidine on the ulcerogenic effect of Orthofen, indomethacin and naproxen].
The influence of retinol, alpha-tocopherol, and cimetidine on ulceration induced by ortophen, indomethacin, naproxen was studied on rats. It was shown that alfa-tocopherol, retinol, and cimetidine reduce the damaging effect of these drugs on the gastroduodenal mucosa of rats thus normalizing the phospholipid content. The influence of alpha-tocopherol and retinol on the side-effects of ortophen was studied in children with rheumatoid arthritis. Ortophen was found to cause gastroduodenal side-effects in more than 30% of patients and decrease the levels of vitamin A and E in children. The use of retinol and alpha-tocopherol in cotherapy decreases the frequency and severity of side-effects and reduces the vitamin deficiency.
Stanislavchuk
N A
NA
Pentiuk
A A
AA
Vovk
O G
OG
Ostapchuk
E I
EI
D000293:Adolescent; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000150:complications / Q000188:drug therapy; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D002927:Cimetidine / Q000627:therapeutic use*; D004008:Diclofenac / Q000009:adverse effects*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D008297:Male; D009288:Naproxen / Q000009:adverse effects*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D014801:Vitamin A; D014810:Vitamin E; D004008:Diclofenac; D009288:Naproxen; D002927:Cimetidine; D007213:Indomethacin
Vliianie retinola, tokoferola i tsimetidina na ul'tserogennyĭ éffekt ortofena, indomtatsina i naproksena.