title: APOE alleles in Alzheimer's disease and vascular dementia in a population aged 85+.
abstract: Apolipoprotein E genotyping was carried out in a stratified random sample of 52 patients with Alzheimer's disease, 48 patients with vascular or mixed dementia, and 49 nondemented controls in a population-based study of people aged 85 and older (the Vantaa 85+ Study). Our results indicate that the apolipoprotein E epsilon 4 allele is associated with approximately a twofold increase in clinically diagnosed Alzheimer's disease in this very old general population aged 85+. When combined with previous studies, our data also suggest that the association is decreasing with age. In contrast, there appears to be no relation between apolipoprotein E alleles and clinically diagnosed vascular dementia.
authors.affiliation: Department of Community Health and General Practice, University of Kuopio, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Sulkava
authors.forename: K
authors.initials: K
authors.lastname: Kainulainen
authors.forename: A
authors.initials: A
authors.lastname: Verkkoniemi
authors.forename: L
authors.initials: L
authors.lastname: Niinistö
authors.forename: E
authors.initials: E
authors.lastname: Sobel
authors.forename: Z
authors.initials: Z
authors.lastname: Davanipour
authors.forename: T
authors.initials: T
authors.lastname: Polvikoski
authors.forename: M
authors.initials: M
authors.lastname: Haltia
authors.forename: K
authors.initials: K
authors.lastname: Kontula
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism*; D015140:Dementia, Vascular / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male
chemical_list: D001057:Apolipoproteins E