title: The nucleotide sequence of human acylamino acid-releasing enzyme.
abstract: The nucleotide sequence of a cDNA coding for the human acylamino acid-releasing enzyme (AARE, also known as acylpeptide hydrolase) [EC 3.4.19.1] subunit has been determined. The amino acid sequence of human AARE subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (91.5%) with both the corresponding proteins from the pig and the rat. The AARE cDNA shows 99.2% identity with a 3.3 kb cDNA transcribed from a locus (DNF15S2) on the short arm of human chromosome 3, whose deletion is associated with small cell lung cancer, taking into consideration that the sequence of the 3.3-kb cDNA previously reported was caused by misreading.
authors.affiliation: Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Otsu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mitta
authors.forename: H
authors.initials: H
authors.lastname: Ohnogi
authors.forename: S
authors.initials: S
authors.lastname: Mizutani
authors.forename: F
authors.initials: F
authors.lastname: Sakiyama
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Tsunasawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002893:Chromosomes, Human, Pair 3; D018076:DNA, Complementary; D006801:Humans; D008099:Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000235:genetics*; D051381:Rats; D013552:Swine
chemical_list: D018076:DNA, Complementary; D010447:Peptide Hydrolases; C038220:acylaminoacyl-peptidase