The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme.
The recent discovery that mammalian thioredoxin reductase is a selenoprotein furnishes an additional explanation of the mutual sparing roles of selenium and vitamin E in cellular antioxidant systems. Thioredoxin reductases isolated from human lung adenocarcinoma cells, human Jurkat T-cells and HeLa cells contain selenocysteine which is located in a C-terminal tripeptide, -Cys-SeCys-Gly.
Tamura
T
T
Okayama University, Faculty of Agriculture, Japan.
Gladyshev
V
V
Liu
S Y
SY
Stadtman
T C
TC
D000595:Amino Acid Sequence; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D008969:Molecular Sequence Data; D012643:Selenium / Q000737:chemistry / Q000494:pharmacology*; D017279:Selenocysteine / Q000737:chemistry*; D013880:Thioredoxin-Disulfide Reductase / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D017279:Selenocysteine; D014810:Vitamin E; D013880:Thioredoxin-Disulfide Reductase; D012643:Selenium