[Modification to the functional status of the hemostatic system with the use of berberine sulfate].
The effect of berberin sulfate (single and chronic administration during 30 days in doses of 0.14-80 mg/kg) on the functional state of hemostasis system was studied on gamma-irradiated (dose 5.0 Gy) and intact Wistar rats and mice (CBA x C57BL)F1. Administration of the drug increases the number of thrombocytes, decreases the activity of factor XIII and promote blood coagulation.
Ziablitskiĭ
V M
VM
Romanovskaia
V N
VN
Umurzakova
R Z
RZ
Starosel'skaia
A N
AN
Mikhal'skaia
T Iu
TIu
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D001780:Blood Coagulation Tests; D004305:Dose-Response Relationship, Drug; D005260:Female; D005720:Gamma Rays; D006487:Hemostasis / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D014916:Whole-Body Irradiation
D000470:Alkaloids; D001599:Berberine
Modifikatsiia funktsional'nogo sostoianiia sistemy gemostaza pri primenenii berberina sul'fata.