Alzheimer's peptides A beta 1-40 and A beta 1-28 inhibit the plasma cholesterol esterification rate.
The amyloid fibrils of Alzheimer's disease and Down's syndrome amyloid deposits are composed mainly of aggregated amyloid beta protein (A beta) which also exists in a soluble form. It has been shown that both Alzheimer's disease and Down's syndrome share another common feature: the decrease in plasma cholesterol esterification in affected individuals. In the present work the effect of synthetic peptides A beta 1-40 and A beta 1-28 on normal human plasma cholesterol esterification rate was studied. Both peptides at a concentration of 1 ng/ml inhibited plasma cholesterol esterification rate to 40-50 % of control value. Statistical analysis showed no differences in the effect of A beta 1-40 and A beta 1-28 on the inhibition, suggesting the importance of A beta sequence 1-28 for this effect.
Koudinov
A R
AR
Department of Pathology, New York University Medical Center, NY 10016, USA. koudinov@mchip00.med.nyu.edu
Koudinova
N V
NV
Berezov
T T
TT
D000328:Adult; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D002788:Cholesterol Esters / Q000097:blood*; D003124:Colorimetry; D004951:Esterification / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D002788:Cholesterol Esters; D010446:Peptide Fragments; C084358:amyloid beta-protein (1-28); C078592:amyloid beta-protein (1-40); D002784:Cholesterol