title: HLA-B27--associated uveitis presenting with diffuse vitritis.
abstract: A 26-year-old man complained of a sudden decrease in vision in the left eye. He had a past medical history of pauciarticular juvenile rheumatoid arthritis with a positive HLA-B27 haplotype and negative antinuclear antibodies and later development of ankylosing spondylitis. His ocular history was unremarkable. An ophthalmic examination revealed a predominant diffuse vitritis (3+) in the left eye. The uveitis improved after treatment with topical and systemic steroids. Following an extensive clinical and laboratory evaluation, a final diagnosis of HLA-B27-associated uveitis was made. Although uncommon, diffuse vitritis can occur in the setting of this uveitis and may be a predominant symptom.
authors.affiliation: Department of Ophthalmology, Hospital de Móstoles, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: O
authors.initials: O
authors.lastname: Sayagues
authors.forename: C
authors.initials: C
authors.lastname: Grande
authors.forename: P
authors.initials: P
authors.lastname: Zarco
mesh_terms: D000328:Adult; D009877:Endophthalmitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006239:Haplotypes; D006801:Humans; D008297:Male; D014605:Uveitis / Q000150:complications / Q000276:immunology*; D014822:Vitreous Body
chemical_list: D015796:HLA-B27 Antigen