Immunosuppressive cyclolignans.
The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.
Gordaliza
M
M
Laboratorio de Química, Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
Faircloth
G T
GT
Castro
M A
MA
Miguel del Corral
J M
JM
López-Vázquez
M L
ML
San Feliciano
A
A
D000818:Animals; D002478:Cells, Cultured; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017705:Lignans / Q000138:chemical synthesis / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D013154:Spleen / Q000166:cytology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D007166:Immunosuppressive Agents; D017705:Lignans