title: Control of pain after photorefractive keratectomy.
abstract: BACKGROUND
  The inadequate control of pain after photorefractive keratectomy remains an important issue for both patients and clinicians.
  
  
  METHODS
  A survey of postoperative pain regimens used in excimer centers worldwide was carried out. A pilot study to assess the temporal basis of pain after photorefractive keratectomy was done by using a visual analog pain score in 30 patients. A comprehensive literature search was undertaken to ascertain the suitability of topical ophthalmic anesthetics in controlling pain after photorefractive keratectomy.
  
  
  RESULTS
  Many drugs, both oral and topical, are used worldwide to control pain after photorefractive keratectomy, but no group has shown satisfactory pain control in all patients. The pilot study revealed that the pain was most severe in the first 24 hours after photorefractive keratectomy and declined to low levels thereafter. Topical anesthetics cause corneal complications when used excessively and for prolonged periods.
  
  
  CONCLUSIONS
  Pain after photorefractive keratectomy is most severe in the first 24 hours. Topical anesthetics would only be needed for this short time and would guarantee pain relief in all patients. We do not anticipate any corneal complications if the anesthetics are used for short times and under close medical supervision.
authors.affiliation: Department of Ophthalmology, St Thomas' Hospital, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Verma
authors.forename: J
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000779:Anesthetics, Local / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D054018:Lasers, Excimer; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D018903:Photorefractive Keratectomy; D010865:Pilot Projects
chemical_list: D000779:Anesthetics, Local