title: In vitro and in vivo testing of an implantable motor-driven left ventricular assist device.
abstract: A totally implantable motor-driven left ventricular assist device (LVAD) has been developed and tested. The performance of this LVAD was tested in a mock circulatory system. This pump provided 8 L/min of output against a mean afterload of 120 mm Hg with a filling pressure of 20 mm Hg when the pump was operated in the fill/empty mode. The right and left pumps were tested in a mock loop. The right pump afterload was kept in the range from 23-32 mm Hg. With increase in the left pump afterload, the pump power output varied from 1.64 to 2.37 W. The instantaneous motor power input varied from 22.6 to 30.6 W with the total system efficiency ranging from 6.7 to 9.4%. To date, 4 in vivo studies have been conducted for up to 12 h. Two animals survived 12 and 10 h, respectively. Termination was due to bleeding in 1 animal, vent tube obstruction in 1, and respiratory failure in 2. All animals died of technical failure. Another experiment is to be undertaken, and a newly designed cannula is now being manufactured.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: D
authors.initials: D
authors.lastname: Kikugawa
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuhiro
authors.forename: S
authors.initials: S
authors.lastname: Kanazawa
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: T
authors.initials: T
authors.lastname: Katsumura
authors.forename: S
authors.initials: S
authors.lastname: Kukunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuura
mesh_terms: D000009:Abdominal Muscles; D000818:Animals; D001672:Biocompatible Materials; D002302:Cardiac Output / Q000502:physiology; D002315:Cardiopulmonary Bypass; D002404:Catheterization; D006353:Heart-Assist Devices / Q000592:standards*; D066298:In Vitro Techniques; D011673:Pulsatile Flow / Q000502:physiology; D012756:Sheep
chemical_list: D001672:Biocompatible Materials