title: In vitro testing of a left ventricular assist device. Study of the effect of its control strategy on energetic relationships inside the left ventricle.
abstract: In this study an original left ventricular assist device is tested on an open loop modular physical circuit reproducing Starling's law of the heart to set an optimal control strategy for heart recovery. It is assumed that the goals of the assistance are reduction of oxygen consumption, external work and improvement of cardiac mechanical efficiency. The assistance is evaluated by the position of a working point on the characteristic surfaces of the ventricle defined by peripheral resistance, atrial pressure and selected variables pertaining to energy (pressure-volume area, external work and cardiac mechanical efficiency). In this frame an optimal assistance for heart recovery is a compromise among different requirements corresponding to a restricted set of control parameters values: driving pressure PZB = 35 kPa and timing values T1 and T2 (systole beginning and systole ending in relation to QRS complex and cardiac cycle duration T) T1 = 0.55.T and T2 = 0.73.T.
authors.affiliation: Institute for Biomedical Technologies CNR, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: K
authors.initials: K
authors.lastname: Gorczynska
authors.forename: C
authors.initials: C
authors.lastname: De Lazzari
authors.forename: K
authors.initials: K
authors.lastname: Grodzicki
authors.forename: R
authors.initials: R
authors.lastname: Mimmo
authors.forename: D
authors.initials: D
authors.lastname: Ambrosi
authors.forename: G
authors.initials: G
authors.lastname: Tosti
mesh_terms: D001674:Bioelectric Energy Sources; D001698:Biomedical Engineering; D003198:Computer Simulation; D004582:Electronics, Medical; D004867:Equipment Design; D006353:Heart-Assist Devices; D006439:Hemodynamics; D066298:In Vitro Techniques; D008954:Models, Biological; D010313:Partial Pressure; D016277:Ventricular Function, Left