Comparison of magnetic resonance imaging and transvaginal ultrasonography with hysterosalpingography in the evaluation of women exposed to diethylstilbestrol.
OBJECTIVE
To compare the ability of magnetic resonance imaging (MRI) and transvaginal ultrasound (TV-US) with that of hysterosalpingography (HSG) in detecting uterine abnormalities caused by in utero diethylstilbestrol (DES) exposure.


METHODS
The study was a prospective MRI and TV-US blind comparison of DES-exposed and nonexposed subjects who had had previous HSG for infertility evaluation.


RESULTS
MRI identified uterine constrictions in 60% of patients and T-shaped uteri in 25% of DES-exposed patients with HSG-confirmed abnormalities. TV-US did not identify uterine constrictions or T-shaped uteri in DES-exposed patients.


CONCLUSIONS
HSG must still be considered the preferred method in evaluating DES-related uterine abnormalities. HSG-defined uterine abnormalities associated with in utero DES exposure were variably identified by MRI and not at all by TV-US.
Kipersztok
S
S
Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, D.C., USA.
Javitt
M
M
Hill
M C
MC
Stillman
R J
RJ
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000075202:Contraindications; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007047:Hysterosalpingography / Q000592:standards*; D008279:Magnetic Resonance Imaging / Q000592:standards*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D014463:Ultrasonography / Q000592:standards*; D014599:Uterus / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology
D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol