[The correction with nooglutil and L-pyroglutamyl-D-alanine amide of cognitive disorders in rats due to intrauterine hypoxia].
Novel nootropic compounds, nooglutyl (N-5-hydroxy(nicotinoyl)-L-glutamine acid, 25 mg/kg/day) and L-pyroglutamyl-D-alanine amide (1 mg/kg/day) administered intracutaneously from the 8th to 20th day of life prevent from movement hyperactivity in "open field", disturbances in ability to training and in memory in an alternate test and in tests of passive and active avoidance and normalize behavior of the adult mail rats (subjected to two-hour hypobaric hypoxia in on the 15-day of intrauterine life, vacuum corresponded to the height 8500 m) in-extrapolation avoidance test. Additionally, nooglutyl recovered the normal growth of rats in the first month of their life, prevented from deceleration of investigating behavior of adults animals and disturbances of the mink reflex in them.
Trofimov
S S
SS
Ostrovskaia
R U
RU
Smol'nikova
N M
NM
Nemova
E P
EP
Gudasheva
T A
TA
Kuznetsova
E A
EA
Voronina
T A
TA
D000818:Animals; D001273:Atmosphere Exposure Chambers; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003214:Conditioning, Classical / Q000187:drug effects; D004151:Dipeptides / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications* / Q000503:physiopathology; D005971:Glutamates / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D009539:Nicotinic Acids / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D004151:Dipeptides; D005971:Glutamates; D009539:Nicotinic Acids; D018697:Nootropic Agents; C066295:nooglutil; C054344:pyroglutamylalanine amide; D011761:Pyrrolidonecarboxylic Acid
Korrekstiia noogliutilom i amidom L-piroglutamil-D-alanina kognitivnykh narusheniĭ u krys, vyzvannykh vnutriutrobnoĭ gipoksieĭ.