[Verapamil binding with the blood erythrocytes and cardiac output in myocardial infarct patients].
In 14 patients with myocardial infarction the degree of verapamil binding with blood erythrocytes after a single oral administration (80 mg/kg) and the dependence pharmacological effect, the minute heart output (+ % MOC), on verapamil content in plasma and erythrocytes were studied. Intraindividual variability of verapamil distribution coefficients between erythrocytes and plasma (RBC/Ptot) is 9.7 +/- 2,3%, and it differs reliably from values of inter-individual variability of this index (33.7 +/- 3.3%).
Makolkin
V I
VI
Gneushev
E T
ET
Vakhliaev
V D
VD
Gneusheva
I A
IA
Shchedrina
I S
IS
D000328:Adult; D002302:Cardiac Output / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D010949:Plasma / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014700:Verapamil / Q000097:blood* / Q000494:pharmacology
D014700:Verapamil
Sviazyvanie verapamila s éritrotsitami krovi i serdechnyĭ vybros u bol'nykh infarktom miokarda.