Anti-IgE in allergic sensitization.
Anti-IgE autoantibodies exist predominantly in the sera of patients with atopic disease. For some time such anti-IgE autoantibodies have been considered a phenomenon that may not be of clinical importance. The cloning of such anti-IgE autoantibodies has eliminated doubts of whether these antibodies exist, but it is still unclear whether such autoantibodies play a pathophysiological role. However, there are ongoing clinical trials that use humanized anti-IgE antibodies for passive immunization of atopic individuals. While this approach may not definitely clarify the role of anti-IgE autoantibodies, it will nevertheless clarify the role of IgE.
Stadler
B M
BM
Institute of Immunology and Allergology, University of Bern, Switzerland.
Rudolf
M P
MP
Zürcher
A W
AW
Miescher
S
S
Vogel
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001323:Autoantibodies / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D003001:Cloning, Molecular; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology*; D014612:Vaccines / Q000276:immunology
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D014612:Vaccines; D007073:Immunoglobulin E