Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress.
Stress may be involved in the pathogenesis of Alzheimer's disease. There is a heat shock element located at position -317 bp on the beta-amyloid precursor protein (beta-APP) gene promoter. Recently we demonstrated [4] that stress, in the form of heat shock, ethanol and sodium arsenite treatment, transcriptionally activates the beta-APP gene. In this report we demonstrate that the nuclear factor that mediates this activation is heat shock factor-1.
Dewji
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Department of Medicine, University of California at San Diego, La Jolla 92093, USA.
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D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis* / Q000235:genetics; D018053:Arsenites / Q000494:pharmacology; D001483:Base Sequence; D002460:Cell Line; D016384:Consensus Sequence; D004268:DNA-Binding Proteins / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology; D000076249:Heat Shock Transcription Factors; D006358:Hot Temperature; D006801:Humans; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D011401:Promoter Regions, Genetic; D017670:Sodium Compounds / Q000494:pharmacology; D013312:Stress, Physiological; D014157:Transcription Factors; D015533:Transcriptional Activation / Q000187:drug effects
D016564:Amyloid beta-Protein Precursor; D018053:Arsenites; D004268:DNA-Binding Proteins; D000076249:Heat Shock Transcription Factors; D009838:Oligodeoxyribonucleotides; D017670:Sodium Compounds; D014157:Transcription Factors; D000431:Ethanol; C017947:sodium arsenite