title: Cutaneous reaction to vasopressin.
abstract: Vasopressin (Pitressin, 8-arginine vasopressin) is a potent vasoconstrictor of splanchnic arterioles. When administered by continuous intravenous infusion, it reduces portal blood flow and pressure and is used in the management of bleeding esophageal varices. We describe a purpuric and necrotic cutaneous reaction to vasopressin that occurred at locations distant from intravenous catheter sites, and we review previous reports of similar reactions.
authors.affiliation: Department of Dermatology, New York Medical College, Valhalla, USA.
authors.forename: G
authors.initials: G
authors.lastname: Lemlich
authors.forename: S
authors.initials: S
authors.lastname: Di Grandi
authors.forename: W K
authors.initials: WK
authors.lastname: Szaniawski
mesh_terms: D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D004932:Esophageal and Gastric Varices / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011693:Purpura / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000473:pathology; D014667:Vasopressins / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014667:Vasopressins