title: Butyric acid, a metabolic end product of anaerobic bacteria, inhibits B-lymphocyte function.
abstract: The effect on B-lymphocytes of butyric acid, a metabolic by-product formed by selected anaerobic bacteria of the subgingival plaque and present in mM amounts in the crevicular fluid of patients affected by adult periodontitis was investigated. A dose-dependent inhibition of both mitogenesis and Ig production in B-cells challenged with formalinized Staphylococcus aureus, strain Cowan I (SAC), was observed. A role of this molecule in the downregulation of the local immune response in periodontal patients is proposed.
authors.affiliation: Department of Periodontology, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: C
authors.initials: C
authors.lastname: Eftimiadi
authors.forename: S
authors.initials: S
authors.lastname: Valente
authors.forename: S
authors.initials: S
authors.lastname: Mangiante
authors.forename: M
authors.initials: M
authors.lastname: Ferrarini
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D003773:Dental Plaque / Q000382:microbiology*; D006801:Humans; D008934:Mitogens; D010514:Periodontal Pocket / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000378:metabolism*
chemical_list: D002087:Butyrates; D008934:Mitogens; D020148:Butyric Acid