Flare-up at contact allergy sites in a gold-treated rheumatic patient.
Contact allergy to gold sodium thiosulfate and gold sodium thiomalate was established by skin testing in a rheumatic patient intended for gold therapy. An intramuscular test dose of gold sodium thiomalate (Myocrisin) induced a flare-up of previously positive epicutaneous and intradermal test reactions, with a histological and immunohistochemical picture compatible with an allergic contact dermatitis. Since gold allergy is frequent, the cutaneous side-effects of gold therapy ("gold dermatitis") may be explained by such an immunopathological reaction.
Möller
H
H
Department of Dermatology, Malmö University Hospital, Sweden.
Larsson
A
A
Björkner
B
B
Bruze
M
M
Hagstam
A
A
D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D001706:Biopsy; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects*; D012971:Gold Sodium Thiosulfate / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010328:Patch Tests; D012867:Skin / Q000187:drug effects / Q000473:pathology
D018501:Antirheumatic Agents; D006052:Gold Sodium Thiomalate; D012971:Gold Sodium Thiosulfate