title: [Granulomatous hepatitis attributed to the combination pyrimethamine-chloroquine].
abstract: After her holiday in South Africa, a 50-year-old woman was admitted because of fever and pain in the upper abdomen. The laboratory tests showed moderately increased serum liver enzyme activities. The liver biopsy showed a granulomatous hepatitis. Further investigations revealed no evidence for sarcoidosis, tuberculosis or infectious hepatitis, nor for other granulomatous diseases or infectious diseases relevant to South Africa. Upon discontinuation of the malaria prophylaxis with Daraclor (pyrimethamine and chloroquine (sulphate)) the symptoms disappeared and the liver function tests returned to normal. It was concluded that Daraclor was the probable cause of granulomatous hepatitis in this patient. This adverse effect was not published before.
authors.affiliation: Afd. Inwendige Ziekten, Catharina Ziekenhuis, Eindhoven.
authors.forename: J J
authors.initials: JJ
authors.lastname: van Everdingen-Bongers
authors.forename: P
authors.initials: P
authors.lastname: Janssen
authors.forename: M
authors.initials: M
authors.lastname: Lammens
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
authors.forename: B
authors.initials: B
authors.lastname: Bravenboer
mesh_terms: D000962:Antimalarials / Q000009:adverse effects*; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002738:Chloroquine / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D011739:Pyrimethamine / Q000009:adverse effects*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D002738:Chloroquine; D011739:Pyrimethamine
vernacular_title: Granulomateuze hepatitis toegeschreven aan de combinatie pyrimethamine-chloroquine.