The molecular basis of somatic hypermutation of immunoglobulin genes.
Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.
Storb
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Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA. stor@midway.uchicago.edu
D000818:Animals; D005803:Genes, Immunoglobulin / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation / Q000276:immunology*