Increase of aldosterone secretion following acute haloperidol administration: possible clinical implications.
The present study was designed to investigate the effect of haloperidol on plasma corticosteroid levels in a small sample of unmediated psychiatric patients requiring acute care. Seven young male normotensive subjects in metabolic balance received a single dose of haloperidol (2 mg i.v.). Blood samples were collected for the radioimmunoassay of plasma renin activity, cortisol and aldosterone concentration at baseline and 3, 6, 12 and 24 h after injection. In five out of seven patients a significant, transient elevation of plasma aldosterone level was observed within 12 h from administration. In contrast, plasma renin activity and cortisol concentration were unchanged. Possible clinical implications of the neuroleptic-associated aldosterone elevations are discussed.
Liberini
P
P
Department of Biomedical Sciences and Biotechnologies, Brescia University School of Medicine, Italy.
Nisoli
E
E
Missale
C
C
Turrina
C
C
Frisoni
G B
GB
Caruso
R
R
Spano
P F
PF
D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000097:blood / Q000494:pharmacology*; D006220:Haloperidol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male
D014150:Antipsychotic Agents; D000450:Aldosterone; D006220:Haloperidol