Molecular abnormalities of bcr gene in some Indian patients with chronic myeloid leukaemia.
The DNAs from 7 unselected Philadelphia chromosome-positive (Ph') chronic myeloid leukaemia (CML) patients were analysed for the distribution of breakpoints in the breakpoint cluster region (bcr) gene by Southern blot. Breakpoints were detected between the regions of exons '2' and '4' of the bcr gene in 5 out of 7 patients. In two patients, breakpoints occurred around exon 4 of the bcr gene. This study presents some information on the nature of breakpoint distribution in the bcr gene of Indian CML patients.
Chandrasekaran
R
R
Department of Toxicology, Fredrick Institute of Plant Protection & Toxicology, Padappai.
Murthy
P B
PB
D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007194:India; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome
D016044:Fusion Proteins, bcr-abl