Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia.
Serotonin-5-HT1A receptors were measured with [3H]8-hydroxy-2-(di-n-propyl)aminotetralin ([3H]8-OH-DPAT) in postmortem prefrontal cortex of 12 pairs of subjects with schizophrenia and age-matched control subjects. The saturation binding isotherms of [3H]8-OH-DPAT revealed high- and low-affinity binding sites. The density (Bmax) of the high-affinity sites was significantly elevated by an average of 79% in subjects with schizophrenia. The dissociation constant (Kd) of the high-affinity sites in subjects with schizophrenia was not significantly different from the control subjects. These results provide further evidence for a role of the serotonergic system in the pathophysiology of schizophrenia.
Sumiyoshi
T
T
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106-500, USA.
Stockmeier
C A
CA
Overholser
J C
JC
Dilley
G E
GE
Meltzer
H Y
HY
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism*; D000328:Adult; D001344:Autopsy; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000032:analysis / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D012016:Reference Values; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology; D014316:Tritium
D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D014316:Tritium; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin