[Low dosage of homoharringtonine for prevention of cicatrization after glaucoma filtering surgery].
To prevent the cicatrization of filtering blebs after glaucoma filtering surgery, subconjunctival injections of low dosage homoharringtonine were administered to 22 glaucomatous eyes (20 patients) postoperatively. The percentage of functional filtering blebs was 90.9% and the mean postoperative IOP was 2.04 +/- 0.68 kPa (1 kPa = 7.5 mmHg). In comparison with the control group, the differences were very significant (P < or = 0.01). The results suggest that the toxicity of low dosage of homoharringtonine be very low, it inhibit fibroblast proliferation and play important roles in the formation of the functional filtering blebs and elevation of the success rate of filtration operation.
Shi
F
F
Department of Ophthalmology, Second Affiliated Hospital, Hebei Medical College, ShiJiazhuang.
Shi
H
H
Li
Z
Z
D000328:Adult; D000368:Aged; D000963:Antimetabolites / Q000008:administration & dosage*; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D018463:Filtering Surgery / Q000009:adverse effects*; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000601:surgery*; D006248:Harringtonines / Q000008:administration & dosage*; D000077863:Homoharringtonine; D006801:Humans; D008297:Male; D008875:Middle Aged
D000963:Antimetabolites; D006248:Harringtonines; D000077863:Homoharringtonine