[A comparative study of fat emulsions clearance test using long chain triglycerides and medium chain triglycerides in volunteers].
Intravenous fat emulsions clearance test using long chain triglycerides (LCT) and medium chain triglycerides (50% MCT/LCT) were studied in ten healthy chinese volunteers. In the morning (8:00 AM) the lipid was infused continuously for 5 hours at rate of 0.17g.kg-1/h. There was an interval of two weeks between LCT and MCT/LCT. The peak concentration of serum triglyceride was smaller in MCT group. The area under concentration curve had significant difference between LCT and MCT groups (6108 +/- 461 vs 4495 +/- 362, P < 0.05). The serum free fatty acid was 628 +/- 42 in LCT and 1049 +/- 1 in MCT respectively in 5 hour (P < 0.001). The concentrations of very low-density lipoprotein (VLDL) in serum were increased in volunteers receiving LCT and MCT, but those of LDL and HDL were decreased. The blood sugar and cholesterol had no significant difference after lipids infusions. The study demonstrated that medium chain triglycerides was faster to be cleared than long chain triglycerides.
He
G
G
PUMC Hospital, CAMS and PUMC, Beijing.
Jiang
Z
Z
Shu
H
H
Wang
X
X
D000328:Adult; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010743:Phospholipids / Q000493:pharmacokinetics*; D013012:Sorbitol / Q000493:pharmacokinetics*; D014280:Triglycerides / Q000493:pharmacokinetics
D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D014280:Triglycerides; C008288:Lipofundin; D013012:Sorbitol