Three autacoids--endogenous digitalis-like factor, clonidine-displacing substance, and quinidine-like immunoreactivity.
The existence of endogenous ligands of opioid receptors prompted research of a potential endogenous digitalis-like factor (DLF) and of endogenous clonidine-displacing substance (CDS). Within eleven years of research, endogenous ouabaine was identified as DLF. It originates in the adrenal cortex. Its physiological role is not yet clear. Most probably, endogenous ouabaine is primarily active in regulation of natriuresis and of blood pressure. The CDS originates in the brain and is active in regulation of blood pressure as well. Its chemical formula was recently identified as agmatine. The potential presence of further autacoids like, e.g. endogenous quinidine-like substance remains to be clarified.
Kölbel
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F
Ist Dept. of Medicine, 2nd Medical Faculty, Charles University, Prague, Czech Republic.
Schreiber
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V
D000818:Animals; D012898:Autacoids / Q000032:analysis / Q000737:chemistry / Q000502:physiology; D002298:Cardenolides; D003000:Clonidine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D004077:Digoxin; D004791:Enzyme Inhibitors / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D011802:Quinidine / Q000276:immunology*; D012503:Saponins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism
D012898:Autacoids; D002298:Cardenolides; D004791:Enzyme Inhibitors; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; C055140:clonidine-displacing substance; D011802:Quinidine; D003000:Clonidine