title: [A multiple center clinical trial on fluconazole for deep-seated fungal infections].
abstract: A multiple center clinical trial was conducted to evaluate the efficacy and safety of domestic fluconazole in treating 913 cases of deep-seated fungal infections. Fluconazole was given 100-200 mg daily for 3 days to 8 months. The results showed that the cure rate and the total efficacy rate were 69.26% and 94.29% respectively. The fungal clearance rate was 93.83%. The main side-effects were nausea, vomiting, diarrhea and abdominal pain, but most of the patients could endure. The side-effect rate was 9.20%. This clinical trial indicated that domestic fluconazole was effective and safe in treating deep-seated fungal infections.
authors.affiliation: First University Hospital, West China University of Medical Sciences, Chengdu.
authors.forename: D
authors.initials: D
authors.lastname: Liang
authors.forename: N
authors.initials: N
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D002177:Candidiasis / Q000188:drug therapy*; D002648:Child; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole