Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment.
Peripheral blood leukocytes interact with the vascular endothelium in a wide range of physiologic and pathophysiologic situations. A current working concept is that activation of vascular endothelium is an important event during the inflammatory response, conferring spatial and temporal localization and leukocyte-type selectivity to the recruitment process. This chapter highlights recent advances in our understanding of the endothelial-dependent molecular mechanisms that mediate recruitment of mononuclear leukocytes (lymphocytes and monocytes) and discusses these advances in the context of chronic inflammatory diseases and their potential therapeutic interventions.
Luscinskas
F W
FW
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Gimbrone
M A
MA
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D007964:Leukocytosis / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology
D015815:Cell Adhesion Molecules