Follow-up of a familial translocation t(10;16) with an unusual segregation pattern.
Bofinger et al. [Am J Med Genet 38:1-8, 1991] reported on a four-generation family with an unusual segregation pattern involving a translocation t(10;16)(q26.3;p13.1). All relatives either had a balanced or unbalanced translocation. We report on five additional relatives, none of whom have a normal karyotype. This unusual segregation pattern may be due to chance or be the result of meiotic drive.
Resta
R G
RG
Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98114-0999, USA.
Luthardt
F
F
Kapur
R
R
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002879:Chromosomes, Human, Pair 10; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010375:Pedigree; D014178:Translocation, Genetic