CRINKLY4: A TNFR-like receptor kinase involved in maize epidermal differentiation.
The maize crinkly4 (cr4) mutation affects leaf epidermis differentiation such that cell size and morphology are altered, and surface functions are compromised, allowing graft-like fusions between organs. In the seed, loss of cr4 inhibits aleurone formation in a pattern that reflects the normal progression of differentiation over the developing endosperm surface. The cr4 gene was isolated by transposon tagging and found to encode a putative receptor kinase. The extracellular domain contains a cysteine-rich region similar to the ligand binding domain in mammalian tumor necrosis factor receptors (TNFRs) and seven copies of a previously unknown 39-amino acid repeat. The results suggest a role for cr4 in a differentiation signal.
Becraft
P W
PW
Department of Zoology, Iowa State University, Ames, IA 50011, USA.
Stinard
P S
PS
McCarty
D R
DR
D000595:Amino Acid Sequence; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D017343:Genes, Plant; D008969:Molecular Sequence Data; D016296:Mutagenesis; D010641:Phenotype; D018515:Plant Leaves / Q000166:cytology; D010940:Plant Proteins; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry; D012639:Seeds / Q000166:cytology; D003313:Zea mays / Q000737:chemistry / Q000166:cytology* / Q000235:genetics / Q000254:growth & development
D004251:DNA Transposable Elements; D010940:Plant Proteins; D018124:Receptors, Tumor Necrosis Factor; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases