Retinoblastoma recurrence after iodine 125 plaque application.
OBJECTIVE
The authors report the clinicopathologic features of a recurrent retinoblastoma after radioactive iodine 125 (125l) plaque therapy.


METHODS
The clinical and histopathologic findings of a 1-year-old boy with a recurrent retinoblastoma after 125l radioactive plaque application were reviewed. The patient's enucleated right eye was processed for routine histologic evaluation. Immunostains for glial fibrillary acid protein and S-100 protein were performed.


RESULTS
Examination of the enucleated eye revealed a retinal tumor composed of two populations of cells. One population consisted of poorly differentiated cells, and the second population at the base of the tumor contained well-differentiated cells with numerous fleurettes. Immunohistochemical stains were positive for glial fibrillary acid protein and S-100 protein in the well-differentiated portion of the tumor.


CONCLUSIONS
This case illustrates a recurrent retinoblastoma that may have arisen from radioresistant well-differentiated cells after 125l plaque therapy.
Spraul
C W
CW
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Lim
J I
JI
Lambert
S R
SR
Grossniklaus
H E
HE
D001918:Brachytherapy; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D014463:Ultrasonography
D007457:Iodine Radioisotopes