[Studies on the in vivo and in vitro chemosensitivity tests using human tumor xenografts].
The in vitro chemosensitivity test has been appreciated as an useful laboratory method for selecting the optimal anticancer drug for solid carcinomas. Using human tumor xenografts, the correlation of in vitro and in vivo tests was studied. The sensitivity results were identical between the two methods for 75% of samples tested. In the other study, five surgically resected specimens were subjected to the in vitro test and were transplanted into nude mice. The in vitro tests were repeated on the xenografts, demonstrating satisfactory reproducibility of the sensitivity results.
Yamada
Y
Y
Department of Surgery, Kitasato Institute Hospital, Kanagawa, Japan.
Yamada
T
T
Asanuma
F
F
Suzuki
T
T
Kawamura
E
E
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000473:pathology*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D016685:Mitomycin / Q000494:pharmacology; D009368:Neoplasm Transplantation; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000473:pathology*; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D016685:Mitomycin; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil