title: Occupational hand dermatitis in a tertiary referral dermatology clinic in Taipei.
abstract: Occupational skin disease is one of the most common occupational diseases. The hand is the most frequent site of involvement in occupational skin disease. We interviewed and examined patients seen in the Contact Dermatitis Clinic of the National Taiwan University Medical Center, a tertiary referral center in Taipei City. For patients suspected of having allergic skin diseases, patch testing was carried out using the European standard series and suspected allergens. Occupational hand dermatitis (OHD) was diagnosed according to medical history, work exposure, physical examination, and patch test findings. 36% of patients seen were diagnosed as having OHD. Electronics, hairdressing, medical, chemical, and construction were the most important industries causing OHD. In the 164 patients with OHD, 58.5% had irritant contact dermatitis (ICD) and 41.5% allergic contact dermatitis (ACD). Dorsal fingers, nail folds, and dorsal hands were most frequently involved in patients with ACD; dorsal fingers, volar fingers and fingertips were most frequently involved in those with ICD. Using logistic regression analysis, we were able to identify the most important clinical presentations that predicted the types of OHD, ACD versus ICD. Patients with atopic history and palm involvement were more likely to have ICD, and those with nail fold involvement more likely to have ACD. In patients with ACD, the most important allergens were dichromate, nickel, cobalt, fragrance mix, epoxy resin, thiuram mix, and p-phenylenediamine. In this study, we identified the important industries and causal agents for OHD. Future preventive measures focused on these industries and agents to reduce OHD will be warranted.
authors.affiliation: Department of Dermatology, National Taiwan University Medical College, ROC.
authors.forename: C C
authors.initials: CC
authors.lastname: Sun
authors.forename: Y L
authors.initials: YL
authors.lastname: Guo
authors.forename: R S
authors.initials: RS
authors.lastname: Lin
mesh_terms: D000046:Academic Medical Centers; D000485:Allergens; D001505:Beauty Culture; D002617:Chemical Industry; D002840:Chromates / Q000009:adverse effects; D003035:Cobalt / Q000009:adverse effects; D004396:Coloring Agents / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology; D003876:Dermatitis, Atopic / Q000453:epidemiology; D017453:Dermatitis, Irritant / Q000453:epidemiology; D009783:Dermatitis, Occupational / Q000453:epidemiology*; D004581:Electronics; D004853:Epoxy Resins / Q000009:adverse effects; D005659:Fungicides, Industrial / Q000009:adverse effects; D006229:Hand Dermatoses / Q000453:epidemiology*; D006801:Humans; D007221:Industry; D016015:Logistic Models; D009260:Nail Diseases / Q000453:epidemiology; D009532:Nickel / Q000009:adverse effects; D016273:Occupational Exposure; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D010655:Phenylenediamines / Q000009:adverse effects; D010820:Physicians; D013624:Taiwan / Q000453:epidemiology; D013893:Thiram / Q000009:adverse effects
chemical_list: D000485:Allergens; D002840:Chromates; D004396:Coloring Agents; D004853:Epoxy Resins; D005659:Fungicides, Industrial; D010476:Perfume; D010655:Phenylenediamines; D013893:Thiram; D003035:Cobalt; D009532:Nickel; C029728:4-phenylenediamine