[Heart surgery, cardiopulmonary bypass and inflammatory response. I. Changes in hemostasis and complement].
The use of cardiopulmonary bypass for surgical cardiac procedures is characterized by a whole-body inflammatory reaction due to the contact of blood through nonendothelialized surfaces; this stimulates the organism to recognize the cardiopulmonary bypass system as "nonself" and to activate specific (immune) and nonspecific (inflammatory) responses. These responses are then related with postoperative damage to many body systems, like pulmonary, renal or brain dysfunction, excessive bleeding and postoperative sepsis. In this paper, present knowledge on untoward responses of the patient to the use of cardiopulmonary bypass in cardiac surgery is reviewed and discussed, particularly focusing on the perturbation of the hemostasis and of the complement activation system.
Parolari
A
A
Cattedra di Cardiochirurgia, Università Degli Studi di Milano, Centro Cardiologico Fondazione Monzino Irccs, Milano.
Alamanni
F
F
Antona
C
C
Stanghellini
M
M
Sandano
S
S
Spirito
R
R
Repossini
A
A
Sala
A
A
Biglioli
P
P
D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D001920:Bradykinin / Q000502:physiology; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003167:Complement Activation; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis; D006801:Humans; D007610:Kallikreins / Q000502:physiology
D001779:Blood Coagulation Factors; D007610:Kallikreins; D001920:Bradykinin
Chirurgia cardiaca, bypass cardiopolmonare e risposta infiammatoria dell'organismo. Parte I: Alterazioni a carico dei processi emostatici e del complemento.