[Effects of qiwei baizhu san in inhibiting replication of human rotavirus in vitro].
Qiwei Baizhu San was found to have an inhibitory effect on human rotavirus (HRV)at monolayer of MA104 Cells. A 50% reduction in plaque number, a 10(1.86)TCID50 decrease in viral replication index and around 60% inhibition in viral RNA synthesis were observed at concentration of 100 mg/ml. Furthermore, the cytotoxicity of the decoction was low, while its promoting effect on growth and proliferation of the culture cells was observed at the concentrations of 12.5-50 mg/ml. The decoction was also found to have effects in prolonging the survival time of HRV infected cells and promoting the regeneration of the infected cells.
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Hunan Academy of TCM, Changsha.
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Wu
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D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology; D008253:Macaca mulatta; D012367:RNA, Viral / Q000096:biosynthesis; D012401:Rotavirus / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D012367:RNA, Viral