title: Small-diameter invasive melanomas: clinical and pathologic characteristics.
abstract: BACKGROUND
  Most melanomas when first diagnosed clinically are larger than common benign melanocytic nevi ( > 6 mm). Smaller melanomas, however, may occasionally occur. Yet, very little is known about them.
  
  
  OBJECTIVE
  To determine the incidence and delineate the clinical and histologic characteristics of small-diameter invasive melanomas.
  
  
  METHODS
  Slides of all melanomas diagnosed between 1984-1993 were reviewed and measured. All invasive lesions less than 6 mm were further scrutinized clinically and morphologically.
  
  
  RESULTS
  Among 357 invasive melanomas, 16 (4.4%) were less than 6 mm. Most lesions lacked some of the histologic features usually seen in large melanomas. One half of them were over 0.75 mm deep. Patients with small melanomas were on average 15 years younger than those with large lesions. In females, sites on the upper extremities predominate. In females, small melanomas had clinical signs of melanoma, while in males they resembled nevi.
  
  
  CONCLUSIONS
  Melanomas smaller than 6 mm are not rare. Clinicians and pathologists must learn their features in order to diagnose them properly.
authors.affiliation: Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez
authors.forename: A J
authors.initials: AJ
authors.lastname: West
authors.forename: J V
authors.initials: JV
authors.lastname: Pitha
authors.forename: J W
authors.initials: JW
authors.lastname: Taira
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*