[The effect of docosatrienoic acid on the potassium channels of outward rectification in the membrane of rat peritoneal macrophages].
Application of docosatrienic acid was shown to dose-dependently decrease the peak K+ current amplitide and accelerate the potassium activation and inactivation kinetics at all membrane potentials. The data obtained suggests a direct effect of docosatrienic acid on the K+ channels in peritoneal macrophages.
Krutetskaia
Z I
ZI
State University, St. Petersburg.
Lebedev
O E
OE
Roshchina
N G
NG
Butov
S N
SN
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D005231:Fatty Acids, Unsaturated; D015221:Potassium Channels; C098879:13,16,19-docosatrienoic acid
Vliianie dokozatrienovoĭ kisloty na kalievye kanaly vykhodiashchego vypriamleniia v membrane peritoneal'nykh makrofagov krysy.