The effects of intra-aortic balloon pumping combined with coronary sinus interventions on failing hearts: a model study.
Cardiac energy balance is an important factor in evaluating cardiac function. In this work, the effects of different assist modalities and their combinations on cardiac energy balance and global cardiac function have been investigated. The simulation results indicate that coronary sinus interventions (CSIs) can provide myocardium with more energy than IABP when coronary arterial stenosis is serious. However, IABP can decrease myocardial energy consumption and enhance cardiac output, which cannot be done by CSIs, under the condition of impaired myocardial contractility. Therefore, we conclude that the combination of IABP and CSIs is the best way of assisting failing circulation.
Zhou
X
X
Department of Electrical Engineering, Tsinghua University, Beijing, P.R. China.
Bai
J
J
Yiang
F
F
D000818:Animals; D002302:Cardiac Output; D003131:Combined Modality Therapy; D003198:Computer Simulation; D003327:Coronary Disease / Q000150:complications*; D004195:Disease Models, Animal; D004285:Dogs; D004734:Energy Metabolism; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D007423:Intra-Aortic Balloon Pumping / Q000379:methods*; D008955:Models, Cardiovascular; D015425:Myocardial Reperfusion / Q000379:methods*; D009206:Myocardium / Q000378:metabolism