Mechanisms of phagocytosis.
Recent advances in research on phagocytosis include a better appreciation of the cross-talk between phagocytic receptors, the definition of multiple signaling domains within these receptors, and a deeper understanding of the downstream effector pathways leading to actin polymerization and particle internalization. Phagosome maturation in macrophages proceeds via a series of membrane fusion and fission events, which modify the phagosome in small increments, and appears to be regulated, in part, by GTP-binding proteins and perhaps by protein kinase C. The isolation of dysphagic mutants of Dictyostelium discoideum presages the identification of new genes required for phagocytosis.
Allen
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LA
Laboratory of Signal Transduction, Rockefeller University, New York, NY 10021, USA. allenl@rockvax.rockefeller.edu
Aderem
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A
D000199:Actins / Q000378:metabolism / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000235:genetics / Q000276:immunology; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
D000199:Actins; D011956:Receptors, Cell Surface