Anabolic effects of progestogens in bone remodelling.
The short-term effects of oestrogen deficiency on biochemical indices of bone turnover were studied in 49 women who had undergone hysterectomy with bilateral ovariectomy. In patients treated with norethisterone or tibolone, a significant reduction was observed in urinary hydroxyproline excretion comparable to that observed in estradiol treated patients. Bone isoenzyme of serum alkaline phosphatase activity did not decrease and bone mass remained increased during norethisterone and tibolone treatments. It is concluded that norethisterone and tibolone can act as bone-trophic hormones.
Stĕpán
J J
JJ
IIIrd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Schreiber
V
V
D000469:Alkaline Phosphatase / Q000378:metabolism; D015519:Bone Density; D016723:Bone Remodeling / Q000187:drug effects*; D001842:Bone and Bones / Q000201:enzymology; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D009640:Norethindrone / Q000008:administration & dosage; D009652:Norpregnenes / Q000008:administration & dosage; D010024:Osteoporosis / Q000209:etiology / Q000503:physiopathology; D010052:Ovariectomy / Q000009:adverse effects; D011372:Progestins / Q000494:pharmacology* / Q000502:physiology; D011446:Prospective Studies
D009652:Norpregnenes; D011372:Progestins; D004958:Estradiol; D000469:Alkaline Phosphatase; C027385:tibolone; D006909:Hydroxyproline; D009640:Norethindrone