The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family.
Here we show that E1, an ankyrin-related, potentially protective, neuronal protein of the human filarial nematode Onchocerca volvulus contains a death domain (DD), most similar to that of human Mort1/FADD (39% identity). In addition, sequence comparison of E1 to its homologue from Litomosoides sigmodontis and to Caenorhabditis elegans ankyrin defines two further putative functional domains. One represents the end of the spectrin-binding domain of ankyrins, the other an unique domain, most highly conserved between these nematodes, containing a calpain sequence motif. Thus, E1 may be involved in apoptosis, raising the possibility that protection against this parasitic helminth may be induced by apoptotic processes.
Erttmann
K D
KD
Section of Molecular Biology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Domeyer
A
A
Gallin
M
M
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D017487:Ankyrins / Q000737:chemistry; D017209:Apoptosis; D017173:Caenorhabditis elegans; D002352:Carrier Proteins / Q000737:chemistry; D017124:Conserved Sequence; D005091:Exons; D053200:Fas-Associated Death Domain Protein; D005370:Filarioidea; D015801:Helminth Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000737:chemistry*; D017181:Onchocerca volvulus / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D017386:Sequence Homology, Amino Acid
D048868:Adaptor Proteins, Signal Transducing; D017487:Ankyrins; D002352:Carrier Proteins; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D015801:Helminth Proteins; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; C100755:neuronal protein E1