Structural polymorphisms of complement receptor 1 (CR1) in systemic lupus erythematosus (SLE) patients and normal controls of three ethnic groups.
CR1 exhibits a molecular weight polymorphism and variability in the number of C3b-binding sites. Because this may affect immune complex clearance, we used erythrocytes to investigate the CR1 size polymorphism in SLE patients from three ethnic groups. The CR1-C allele was found more frequently in African-Americans, but the frequency did not differ between controls (10%, n = 63) and SLE patients (9%, n = 79). A 160-kD band similar to CR1-C was noted in a number of patients and was shown to be a proteolytic cleavage fragment. The study shows that the smallest form of CR1, i.e. CR1-C, is not a genetic risk factor for SLE and that the frequencies of the CR1 structural alleles do not differ from race-matched healthy controls.
Moulds
J M
JM
Department of Internal Medicine, University of Texas, Houston Medical School 77030, USA.
Reveille
J D
JD
Arnett
F C
FC
D000483:Alleles; D044383:Black People / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D017058:Mexican Americans; D008970:Molecular Weight; D012150:Polymorphism, Restriction Fragment Length; D017463:Receptors, Complement 3b / Q000737:chemistry / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
D017463:Receptors, Complement 3b