title: Unexplained high activity of aspartate aminotransferase (EC 2.6.1.1): a case report.
abstract: We report a case of unexplained and persistently elevated ASAT activity in serum. This appeared to be due to a macro-enzyme of ASAT, as was demonstrated by protein-A-Sepharose treatment of the serum sample. Although macro-ASAT seems to be clinically irrelevant, unexplained raised ASAT activity without acknowledgement of its macroenzyme nature may lead to unnecessary diagnostic procedures.
authors.affiliation: Department of Clinical Chemistry, Diagnostic Center SSDZ, Delft, Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: de Jonge
authors.forename: A
authors.initials: A
authors.lastname: Houwing
mesh_terms: D001219:Aspartate Aminotransferases / Q000032:analysis / Q000097:blood*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D001219:Aspartate Aminotransferases