[Immunohistochemical characterization and ultrastructural features of cervical squamous cell carcinoma of ectocervical and endocervical (cambial cell or metaplastic) genesis].
Among 199 invasive squamous cell carcinomas immunophenotype of ectocervical carcinoma (true squamous cell one) was found in 18 tumors. Immunophenotype of metaplastic, endocervical squamous cell carcinoma was established in 181 cases. There was a pronounced expression of cytokeratins N 1, 2, 10, 14 and negative or weak expression of N 8 and 17. Ultrastructural features of this carcinoma type were desmosomes on microprocesses, abundant bundles of cytoplasmic tonofibrils. A high level of cytokeratins N 8 and 17, carcinoembryonic antigen was found in squamous cell endocervical carcinoma; at the same time keratins N 1, 2, 10 and 14 were weakly expressed, there was also a characteristic ultrastructure of intercellular contacts (desmosomes on flat surfaces) and microvilli. The results allow to use immunohistochemical and ultrastructural methods for differential diagnosis of squamous cell carcinoma originating from different sources.
Petrov
S V
SV
Raĭkhlin
N T
NT
Serre
G
G
Smedts
F
F
D002272:Carcinoembryonic Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000209:etiology / Q000648:ultrastructure*; D003896:Desmosomes / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007633:Keratins / Q000032:analysis; D008679:Metaplasia; D008871:Microvilli / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000209:etiology / Q000648:ultrastructure*
D002272:Carcinoembryonic Antigen; D007633:Keratins
Immunogistokhimicheskaia kharakteristika i ul'trastrukturnye osobennosti ploskokletochnogo raka sheĭki matki éktotservikal'nogo i éndotservikal'nogo (rezervnokletochnogo ili metaplasticheskogo) geneza.