Salivary eicosanoid concentration in patients with Sjögren's syndrome.
OBJECTIVE
To investigate eicosanoid concentrations in the saliva of patients with primary Sjögren's syndrome (SS).


METHODS
Whole mixed saliva of 36 subjects was assayed for eicosanoid concentrations using a radioimmunoassay. Patients with primary SS having positive lip biopsy served as the study group; their results were compared with data from patients with dry mouth and negative lip biopsy (dry mouth group), and with a group of normal healthy controls.


RESULTS
Concentrations of thromboxane B2 were significantly (p < 0.01) increased in 18 patients with primary SS compared with 10 patients with dry mouth and eight healthy normal controls (1.95 (SD 0.51) ng/ml saliva compared with 0.52 (0.1) ng/ml and 0.3 (0.1) ng/ml, respectively). Similarly, prostaglandin E2 concentrations were also significantly increased (p < 0.01) in 11 patients with primary SS compared with five patients with dry mouth and eight normal controls (3.75 (0.82) ng/ml saliva compared with 0.32 (0.1) ng/ml and 0.41 (0.1) ng/ml, respectively).


CONCLUSIONS
Salivary concentrations of eicosanoids are significantly increased in patients with primary SS, and this may prove helpful in the diagnosis of this disease.
Tishler
M
M
Department of Rheumatology, Ichilov Hospital, Tel Aviv-Sourasky Medical Centre, Israel.
Yaron
I
I
Raz
A
A
Meyer
F A
FA
Yaron
M
M
D015415:Biomarkers / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D015777:Eicosanoids / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism; D011863:Radioimmunoassay; D012463:Saliva / Q000737:chemistry*; D012859:Sjogren's Syndrome / Q000378:metabolism*; D013929:Thromboxane B2 / Q000032:analysis
D015415:Biomarkers; D015777:Eicosanoids; D013929:Thromboxane B2; D015232:Dinoprostone