title: Developing and shedding inhibitions: how MHC class II molecules reach maturity.
abstract: Over the past year, several important advances have been made in understanding the mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside antigen-presenting cells. Recent progress in the study of class II antigen presentation includes the identification of ligands from which invariant chain protects class II molecules in pre-endosomal compartments, an improved understanding of how invariant chain inhibits antigenic peptide binding, and the appreciation that HLA-DM (a factor important for antigen presentation in vivo) can act as a catalyst for peptide exchange.
authors.affiliation: Joseph Stokes Jr Research Institute, Children's Hospital of Philadelphia, PA 19104, USA.
authors.forename: R
authors.initials: R
authors.lastname: Busch
authors.forename: E D
authors.initials: ED
authors.lastname: Mellins
mesh_terms: D017951:Antigen Presentation; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D011992:Endosomes / Q000276:immunology / Q000378:metabolism; D006681:HLA-D Antigens / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D018448:Models, Immunological; D011485:Protein Binding
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II; D008024:Ligands; C045084:invariant chain