title: Commitment to division in ciliate cell cycles.
abstract: Near the end of the cell cycle, ciliates commit irreversibly to cell division. The point of commitment occurs at the time of oral polykinetid assembly and micronuclear anaphase. The commitment is a checkpoint which requisites a threshold cell mass/DNA ratio and stomatogenesis. It is also a physiological transition point, involving cdk protein kinases similar to those of other eukaryotes. Both P34 kD and P36 kD kinases, similar to the S. pombe cdc2 kinases, have been described to have activity as monomers. Subsequent to commitment to division, dramatic cytoskeletal modifications occur for separation of organelles, cortex morphogenesis and cytokinesis. Numerous mutants affecting cytoskeletal function associated with the division process have been obtained in several species. Of these, only the cc1 mutant in Paramecium affects cell cycle progression prior to commitment to division. The material reviewed is used to speculate about the mechanisms of regulation of pre-fission morphogenesis and cell division related processes in ciliates.
authors.affiliation: Department of Zoology, University of British Columbia, Vancouver, Canada.
authors.forename: S M
authors.initials: SM
authors.lastname: Adl
authors.forename: J D
authors.initials: JD
authors.lastname: Berger
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D016798:Ciliophora / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D008954:Models, Biological; D010247:Paramecium / Q000166:cytology / Q000235:genetics / Q000254:growth & development; D011494:Protein Kinases / Q000378:metabolism; D012568:Schizosaccharomyces / Q000166:cytology
chemical_list: D011494:Protein Kinases; D018844:Cyclin-Dependent Kinases