Effects of fluoxetine and olfactory bulbectomy on mouse circadian activity rhythms.
Olfactory bulbectomy (OBX) in SWR outbred male mice lengthened the free-running period and delayed the phase of a circadian rhythm for wheel-running activity. OBX also increased mean levels of activity. Two weeks of daily intraperitoneal injections of Fluoxetine (8 mg/kg), a serotonin re-uptake inhibitor, reversed the effects of bulbectomy on the mean level of activity and significantly shortened the free-running period of the activity rhythm. The phase of the activity rhythm was not significantly affected by the Fluoxetine treatment. These results are consistent with a hyposerotonergic mediation of the effects of OBX on circadian period and activity level.
Possidente
B
B
Biopsychology Program, Skidmore College, Saratoga Springs, NY 12866, USA.
Lumia
A R
AR
McGinnis
M Y
MY
Rapp
M
M
McEldowney
S
S
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D009830:Olfactory Bulb / Q000502:physiology*
D005473:Fluoxetine