title: Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain.
abstract: A novel approach is presented for imaging macromolecule and metabolite signals in brain by proton magnetic resonance spectroscopic imaging. The method differentiates between metabolites and macromolecules by T1 weighting using an inversion pulse followed by a variable inversion recovery time before localization and spectroscopic imaging. In healthy subjects, the major macromolecule resonances at 2.05 and 0.9 ppm were mapped at a nominal spatial resolution of 1 x 1 x 1.5 cm3 and were demonstrated to be highly reproducible between subjects. In subacute stroke patients, a highly elevated macromolecule resonance at 1.3 ppm was mapped to infarcted brain regions, suggesting potential applications for studying pathological conditions.
authors.affiliation: Department of Neurology, Yale Medical School, New Haven, CT 06520-8043, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Hwang
authors.forename: G D
authors.initials: GD
authors.lastname: Graham
authors.forename: K L
authors.initials: KL
authors.lastname: Behar
authors.forename: J R
authors.initials: JR
authors.lastname: Alger
authors.forename: J W
authors.initials: JW
authors.lastname: Prichard
authors.forename: D L
authors.initials: DL
authors.lastname: Rothman
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
chemical_list: D046911:Macromolecular Substances