Effect of captopril on membrane currents of ventricular myocytes.
Using whole-cell patch-clamp technique, the present study examined the effects of captopril on membrane currents of ventricular myocytes. The results were as follow: when the concentration of captopril was 6 x 10(-4)mol, the fast inward sodium current and slow inward calcium current were all decreased significantly (P < 0.05). Besides, when the concentration exceeds 10(-3)mol, the delayed rectifier potassium current was increased (P < 0.05) as well. But if the experimental concentration was under 6 x 10(-4)mol, these three kinds of currents was not affected. These findings suggested that captopril has no direct antiarrhythmic effect at the average therapeutic serum level.
Wang
Y G
YG
Department of Cardiology, Tongji Hospitol, Tongji Medical University, Wuhan.
Lu
Z Y
ZY
D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D015220:Calcium Channels; D015221:Potassium Channels; D015222:Sodium Channels; D002216:Captopril