The genes encoding the 5HT1D alpha and 5HT1D beta receptors are unchanged in patients with panic disorder.
To determine the serotonergic function in panic disorder, sequencing of the genes encoding the 5HT1D alpha and 5HT1D beta receptors was carried out. The genes for the 5HT1D alpha and 5HT1D beta receptors were amplified by polymerase chain reaction and sequenced by the dideoxy method. Some patients have both nucleotides C and T at position 1080 in 5HT1D alpha receptor gene; however, both of them code the same amino acid, asparagine. The 5HT1D beta receptor gene had a substitution from GCA276 to GCG276, not only panic disorder but also in controls; however, this substitution does not change the corresponding amino acid, alanine92.
Ohara
K
K
Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.
Xie
D W
DW
Ishigaki
T
T
Deng
Z L
ZL
Nakamura
Y
Y
Suzuki
Y
Y
Miyasato
K
K
Ohara
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016584:Panic Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016133:Polymerase Chain Reaction; D011985:Receptors, Serotonin / Q000145:classification / Q000235:genetics*
D011985:Receptors, Serotonin; D004247:DNA