Cervical intra-epithelial neoplasia in women infected with human immunodeficiency virus.
OBJECTIVE
To investigate the relationship between human immunodeficiency virus (HIV) and cervical intra-epithelial neoplasia (CIN).


METHODS
A prospective study to determine the prevalence of cervical intra-epithelial neoplasia in 111 HIV-positive women.


METHODS
In total, 111 HIV + women were enrolled and underwent cervical biopsy and CD4 T-lymphocyte determination. Of the 111 women, 26 (23.4%) had CIN and another 26 (23.4%) had histologic evidence of cervicitis.


RESULTS
No significant difference was found between transmission group, CDC stage of disease, CD4 T-lymphocyte count and pregnancy. There was a significant association with concomitant human papillomavirus (HPV) infection (P < 0.001).


CONCLUSIONS
Public health measures are needed to provide Papanicolaou smear screening and appropriate clinical follow-up and treatment of women infected with the human immunodeficiency virus.
Bongain
A
A
Department of Obstetrics-Gynecology, Reproductive and Fetal Medicine, Hôpital St. Roch, Nice, France.
Rampal
A
A
Durant
J
J
Michiels
J F
JF
Dellamonica
P
P
Gillet
J Y
JY
D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000276:immunology / Q000821:virology; D011261:Pregnancy Trimester, First; D015995:Prevalence; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000276:immunology / Q000821:virology*