Growth-suppressive activities of serine protease inhibitors, ONO-3403 and ONO-5046, toward normal and transformed murine fibroblasts.
ONO-3403 and ONO-5046 are potent synthetic protease inhibitors of trypsin and elastase, respectively. These compounds suppressed the proliferation of polyoma virus- and Kirsten sarcoma virus-transformed BALB/c 3T3 cells more effectively than their normal counterparts. SV40-transformed 3Y1 and v-Ha-ras-transformed NIH3T3 cells were also more sensitive to ONO-3403 and ONO-5046 than the parent normal cells. These results suggest that ONO-3403 and ONO-5046 are useful for selective suppression of the proliferation of rapidly growing transformed cells.
Hiwasa
T
T
Division of Biochemistry, Chiba Cancer Center Research Institute, Japan. thiwasa@biolab.kazusa.or.jp
Ohkoshi
M
M
D016475:3T3 Cells; D000501:Allylglycine / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D001550:Benzamidines / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects*; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004305:Dose-Response Relationship, Drug; D011905:Genes, ras; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D015842:Serine Proteinase Inhibitors / Q000633:toxicity*; D013539:Simian virus 40; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000633:toxicity*
D001550:Benzamidines; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; C100807:ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate; D000501:Allylglycine; C069195:sivelestat; D005998:Glycine