title: Scintigraphic evaluation of 99mTc-methylene diphosphonate uptake in the navicular area of horses with lameness isolated to the foot by anesthesia of the palmar digital nerves.
abstract: OBJECTIVE
  To evaluate distribution and intensity of 99mTc-methylene diphosphonate (99mTc-MDP) uptake in the navicular area in horses with forelimb lameness isolated to the palmar aspect of the foot.
  
  
  METHODS
  Prospective, case-controlled study.
  
  
  METHODS
  7 horses with clinical signs of navicular syndrome and 7 control horses.
  
  
  METHODS
  Palmar view, soft tissue-phase scintigraphic images of the foot were obtained between 7 and 12 minutes after injection of 120 to 170 mCi of 99mTc-MDP. Lateral and palmar view, bone-phase images were obtained at 30 minutes and 1, 2, and 4 hours after injection. Palmar views were evaluated by determining the ratio of image density in the navicular area to mean image density in the distal phalangeal area. Palmar and lateral view, bone-phase images were also scored on the basis of navicular area intensity (intense = 3, moderate = 2, mild = 1, and no uptake = 0). Density ratios and mean scores were evaluated as a three-way ANOVA.
  
  
  RESULTS
  Mean navicular-to-distal phalangeal density ratio for affected horses (1.77) was significantly (P = 0.003) greater than that for control horses (0.97). The mean subjective score for affected horses when evaluating palmar views only (1.85) and when evaluating palmar and lateral view pairs together (1.99) was significantly (P < 0.01) higher than scores for control horses (0.51, 0.62). Images obtained 1 hour after injection were as good at differentiating affected from control horses as images obtained between 2 to 4 hours after injection.
  
  
  CONCLUSIONS
  A substantial number of horses with palmar foot pain have increased scintigraphic uptake within the navicular bone 1 to 4 hours after injection of 99mTc-MDP. Lateral view, bone-phase images are less sensitive than palmar view, bone-phase images in revealing navicular area uptake.
  
  
  CONCLUSIONS
  A combination of lateral and palmar view scintigraphic images obtained between 1 and 4 hours after injection of 99mTc-MDP is a useful diagnostic aid in evaluating navicular bone involvement in horses with forelimb lameness isolated to the palmar aspect of the foot.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 6521, USA.
authors.forename: K G
authors.initials: KG
authors.lastname: Keegan
authors.forename: D A
authors.initials: DA
authors.lastname: Wilson
authors.forename: J C
authors.initials: JC
authors.lastname: Lattimer
authors.forename: A R
authors.initials: AR
authors.lastname: Twardock
authors.forename: M R
authors.initials: MR
authors.lastname: Ellersieck
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005528:Foot / Q000000981:diagnostic imaging*; D005534:Foot Diseases / Q000000981:diagnostic imaging / Q000662:veterinary*; D005552:Forelimb; D005684:Gait; D015902:Gamma Cameras; D006734:Horse Diseases; D006736:Horses; D009069:Movement Disorders / Q000000981:diagnostic imaging / Q000662:veterinary*; D011877:Radionuclide Imaging; D012016:Reference Values; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D013669:Technetium Tc 99m Medronate