Role of endogenous platelet-activating factor in the regulation of pancreatic blood flow during caerulein stimulation.
The role of endogenous platelet-activating factor (PAF) in the control of pancreatic blood flow during caerulein stimulation was investigated. Pancreatic blood flow in anesthetized rats was measured continuously by laser Doppler flowmetry for 2 h during the intravenous infusion of caerulein (0.25 micrograms/kg per h). Pancreatic blood flow showed a gradual, consistent, and significant increase, reaching 114.2 +/- 2.3% of the basal value after 120 min. Changes in pancreatic blood flow induced by caerulein were completely inhibited by a cholecystokinin (CCK) antagonist (loxiglumide, 5 mg/ kg per h, i.v.) and by a specific PAF antagonist (CV-6209, 1 mg/kg, i.v.-bolus). Systemic blood pressure remained stable in all groups. These results suggest an important role of endogenously yielded PAF in regulating pancreatic blood flow during caerulein stimulation to the pancreas.
Ogura
M
M
Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Kubota
Y
Y
Inoue
K
K
D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D017078:Laser-Doppler Flowmetry; D008297:Male; D010179:Pancreas / Q000098:blood supply*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors
D005765:Gastrointestinal Agents; D006727:Hormone Antagonists; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; C053321:CV 6209; C053737:loxiglumide; D002108:Ceruletide; D002766:Cholecystokinin; D011377:Proglumide