[Homocysteine, a less well-known risk factor in cardiac and vascular diseases].
Hyperhomocyst(e)mia (Hcy) negatively influences vascular endothelium and coagulation factors. Association of Hcy with premature arteriosclerosis (rather than atherosclerosis), stroke, myocardial infarction and peripheral arterial and venous disease was proved in clinical and epidemiological studies, even as the association with conventional risk factors like age, male sex, smoking, hypertension and hypercholesterolemia. Vitamin substitution of folates, vitamin B6 and B12 decreases Hcy blood levels, however definite evidence is still lacking, whether it results in lower incidence and mortality from cardiovascular diseases. Therefore clinical and epidemiological studies are necessary. Before the grant-application we proved in a pilot study significantly higher Hcy levels in 97 patients with manifest ischaemic heart disease than in 37 controls.
Simon
J
J
II. interní klinika LF UK a FN Plzen.
Racek
J
J
Rosolová
H
H
D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism; D005260:Female; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D006710:Homocysteine
Homocystein, ménĕ známy rizikový faktor srdecních a cévních chorob v populaci.