title: Cutaneous manifestations of congenital afibrinogenaemia.
abstract: Skin problems from coagulation disorders have rarely been described in the dermatological literature. Here we report a patient with a complete congenital absence of fibrinogen which led to leg ulceration, necrosis of the toes and a life-threatening haemorrhage following skin biopsy. This patient shows that leg ulcers may have a complex aetiology and can reflect serious underlying disease.
authors.affiliation: Department of Dermatology, University of Munich, Germany.
authors.forename: R A
authors.initials: RA
authors.lastname: Rupec
authors.forename: P
authors.initials: P
authors.lastname: Kind
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000150:complications* / Q000151:congenital; D005260:Female; D006801:Humans; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology