[Contemporary opinions on the use of aspirin, heparin and thrombolytic therapy in unstable angina pectoris--pathogenetic findings versus results of many clinical tests].
We summed up the results of clinical researches on thrombolysis in unstable angina pectoris (UAP). We also presented results of similar researches on aspirin and-or versus-heparin in UAP. The idea of applying thrombolytic therapy in UAP was based on data of anatomopathologic, coronary angiographic, biochemical and recently intracoronary ultrasonographic findings. These data indicated that the acute coronary syndromes (UAP, non-Q wave and Q-wave myocardial infarction) were very often caused by coronary plaque disruption and thrombosis. Although the efficiency of thrombolytic therapy in UAP was confirmed angiographically, nevertheless thrombolysis did not significantly decrease in-hospital cardiac events. Bleeding complications were significantly higher in patients who had received thrombolytic therapy. Heparin in constant i.v. infusion and aspirin administered orally seemed to improve clinical outcome. Thrombolytic therapy is not recommended in patients diagnosed as having unstable angina pectoris.
Popiel
M
M
Z I Kliniki Kardiologii Akademii Medycznej w Poznaniu.
Grajek
S
S
Cieśliński
A
A
D000789:Angina, Unstable / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D000792:Angiography; D001241:Aspirin / Q000627:therapeutic use*; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013927:Thrombosis / Q000150:complications / Q000517:prevention & control; D016896:Treatment Outcome
D006493:Heparin; D001241:Aspirin
Współczesne poglady na zastosowanie aspiryny, heparyny i trombolizy w dławicy piersiowej niestabilnej--konfrontacja przesłanek patogenetycznych z wynikami wielu badań klinicznych.