A pathogenic challenge model for adult northern bobwhite (Colinus virginianus) using a vaccine strain of Pasteurella multocida type 3.
A pathogenic challenge model causing approximately 50% mortality was developed in adult Northern bobwhite (Colinus virginianus) using Avichol, a live vaccine containing the Clemson University (CU) strain of Pasteurella multocida Type 3. A dose of 2300 or 3000 colony-forming units (CFU) of Avichol injected intramuscularly resulted in 30 to 75% mortality, whereas a dose of 230 CFU or less resulted in no mortality, and 58,720 CFU or more resulted in death in all birds challenged. Primary and secondary vaccination of Northern bobwhite with a formalinized anaculture of Avichol -derived P. multocida resulted in protection against challenge in three separate experiments. Dexamethasone treatment of birds during vaccination resulted in decreased protection against challenge exposure.
Dabbert
C B
CB
Department of Zoology, Oklahoma State University, Stillwater 74078, USA.
Lochmiller
R L
RL
Morton
R J
RJ
Powell
K C
KC
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D001715:Bird Diseases / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D003088:Colinus / Q000276:immunology*; D003907:Dexamethasone / Q000008:administration & dosage; D010326:Pasteurella Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000276:immunology*
D001428:Bacterial Vaccines; D003907:Dexamethasone