Pharmacokinetics of all-trans-retinoic acid in Japanese patients with acute promyelocytic leukemia.
All-trans-retinoic acid (ATRA) was administered at 45 mg/m2 to 4 Japanese patients with acute promyelocytic leukemia (APL). A pharmacokinetic study revealed that the mean peak plasma concentration was 208 ng/ml and was reached at 150 min after ingestion. The mean area under the concentration x time curve (AUC) was 498 ng.h/ml. Two patients showed a good hematological response to ATRA, and they had higher peak plasma concentrations of ATRA and larger AUCs. In one patient, dose escalation of ATRA (90 mg/m2) increased the plasma concentration markedly. In another patient, the plasma concentration decreased markedly in the fasting state. A larger pharmacokinetic study is necessary to examine the influence of food on the absorption of this agent and an optimum administration schedule of ATRA in Japanese APL cases.
Usuki
K
K
Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan.
Endo
M
M
Osawa
M
M
Kitazume
K
K
Iki
S
S
Urabe
A
A
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007564:Japan; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood*; D008297:Male; D014212:Tretinoin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D014212:Tretinoin