title: Dynamics of fever and the cytokine network in systemic juvenile arthritis.
abstract: OBJECTIVE
  To determine the levels of the inflammatory cytokines IL1 alpha, IL1 beta, TNF alpha, IL6, IL8 and of their inhibitors TNF-sR55, TNF-s R75 and IL1-Ra during temperature elevation in systemic juvenile chronic arthritis.
  
  
  METHODS
  Fifty-six serum samples were collected at regular intervals from seven children during 8 fever cycles. Cytokine levels were determined using enzyme-linked immunoassays.
  
  
  RESULTS
  Levels of IL1 alpha, IL1 beta, TNF alpha and IL8 showed no variations. In contrast, IL6 and IL1-Ra levels paralleled the fever spikes. TNF-sR75 levels were also correlated with the fever.
  
  
  CONCLUSIONS
  Fever dynamics in systemic juvenile chronic arthritis may be partly related to cytokine variations.
authors.affiliation: Pediatric Rheumatology Department, Enfants-Malades Teaching Hospital, Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Prieur
authors.forename: P
authors.initials: P
authors.lastname: Roux-Lombard
authors.forename: J M
authors.initials: JM
authors.lastname: Dayer
mesh_terms: D001171:Arthritis, Juvenile / Q000097:blood / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005334:Fever / Q000503:physiopathology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha