[Correlation between p-53 expression and clinical resistance in testicular cancer].
One of the most common cellular gene which negatively regulates the cell cycle, thus functioning as tumour suppressor gene, is the p-53 gene. The presence of this mutated gene has been correlated with, the aggressiveness of several malignant neoplasmas. Expression of the p-53 gene product protein was screened in 55 untreated human germ cell testicular tumours, furthermore a relationship between p-53 expression and clinical resistance was investigated. Using monoclonal antibody and immunoenzyme staining elevated p-53 level could be demonstrated in nuclei of embryonal carcinoma (84%) and seminoma components (56%). Most of the choriocarcinoma cases showed positive staining. Teratomas expressed this antigen negatively or scarcely. In seminomas the highest level of p-53 was stated in stage I. In contrast the opposite tendency could be demonstrated in embryonal carcinomas where p-53 was ++ positive in stage III. Between the high level of p-53 and clinical resistance a converse correlation could be stated because the resistant tumours expressed no or low, the sensitive tumours high level of p-53 protein (P 0.01). These results suggest that elevated p-53 expression could be a prognostic marker of sensitivity in testis cancer.
Hanna
E
E
Országos Onkológiai Intézet, Budapest, Cytopathologiai Osztály.
Bodrogi
I
I
Institoris
E
E
Bak
M
M
D000911:Antibodies, Monoclonal / Q000276:immunology; D018236:Carcinoma, Embryonal / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D002822:Choriocarcinoma / Q000235:genetics / Q000276:immunology / Q000473:pathology; D015870:Gene Expression; D016147:Genes, Tumor Suppressor / Q000235:genetics* / Q000276:immunology; D016158:Genes, p53; D018237:Germinoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D018239:Seminoma / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal
A p-53 expresszió és a klinikai rezisztencia összefüggésének vizsgálata hererákokban.