title: Anti-DNA antibody kinetics following selective removal by adsorption using dextran sulphate cellulose columns in patients with systemic lupus erythematosus.
abstract: The aim of this study is to determine by mathematical analysis which of two models, the one- or the two-compartment model, more closely approximates the kinetics of anti-dsDNA following immunoadsorption procedures in patients with systemic lupus erythematosus. Titers of anti-dsDNA were measured at specified intervals after apheresis to each model by nonlinear least-squares methods, and Akaike's Information Criterion (AIC) was calculated to determine which model most approximately described the kinetics. The AIC of the two-compartment model was larger than that of the one-compartment model in all 14 SLE patients (P < .001). Therefore, the one-compartment model is thought to be suitable. The generation rate and catabolic rate of anti-dsDNA were obtainable using this model. The anti-dsDNA replenishment curve after an immunoadsorption session was defined by only two parameters: the generation and catabolic rates of anti-dsDNA.
authors.affiliation: National Defense Medical College, Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuki
authors.forename: T
authors.initials: T
authors.lastname: Hidaka
authors.forename: T
authors.initials: T
authors.lastname: Ishizuka
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
authors.forename: S
authors.initials: S
authors.lastname: Takata
authors.forename: H
authors.initials: H
authors.lastname: Kutsuki
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D016264:Dextran Sulfate; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D007700:Kinetics; D008024:Ligands; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D015233:Models, Statistical; D017186:Titrimetry
chemical_list: D001323:Autoantibodies; D008024:Ligands; D004247:DNA; D016264:Dextran Sulfate