title: [Preparation of oral berberine bisulfate liposomes].
abstract: The co-precipitate has been made from berberine bisulfate and polyvingyl pyrrolidone (PVP) with the ratio of 1 : 5. The liposomes entrapped berberine bisulfate have been prepared with the ration of drug to lipid 1 : 20 and the ratio of cholesterol to soy phosphatide 2 : 7. The percentage of encapsulation is 48.72%. The test in vivo of small intestinal absorption in rats shows that liposomes can increase the absorption by 4-fold odd compared with free ber-berine bisulfate.
authors.affiliation: Nanjing Institute of Materia Medica.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.forename: G
authors.initials: G
authors.lastname: Weng
authors.forename: J
authors.initials: J
authors.lastname: He
authors.forename: B
authors.initials: B
authors.lastname: Xu
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001599:Berberine / Q000008:administration & dosage*; D004337:Drug Carriers; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000502:physiology; D008081:Liposomes; D011205:Povidone; D051381:Rats
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D008081:Liposomes; D001599:Berberine; D011205:Povidone