Increased serum levels of circulating intercellular adhesion molecule-1 in patients with myocarditis.
Levels of circulating intercellular adhesion molecule-1 (cICAM-1) were measured by ELISA in the sera of 21 patients with unexplained cardiac dysfunction. By evaluating the biopsy or autopsy specimens, they were classified into two groups: a myocarditis group (n = 8) and a nonmyocarditis group (n = 13). Levels of cICAM-1 were significantly higher in the myocarditis group (p < 0.01). Increased levels of cICAM-1 (> 2 SD above the control mean) were detected in 6 of 8 patients in the myocarditis group. Therefore, the detection of increased levels of cICAM-1 could be a useful marker for myocarditis.
Toyozaki
T
T
Third Department of Internal Medicine, Chiba University School of Medicine, Japan.
Saito
T
T
Takano
H
H
Mori
H
H
Kikuchi
T
T
Karaki
A
A
Iijima
Y
Y
Nakamura
Y
Y
Masuda
Y
Y
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006331:Heart Diseases / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000097:blood* / Q000473:pathology
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1