title: Advanced cicatricial retinopathy of prematurity--outcome and complications.
abstract: OBJECTIVE
  To assess the outcome and complications of patients with advanced retinopathy of prematurity (ROP).
  
  
  METHODS
  All patients with eyes achieving stage 4 or 5 retinopathy of prematurity were reviewed. Twenty one eyes were diagnosed during ROP screening in maternity hospitals and 10 eyes were of infants transferred for treatment.
  
  
  RESULTS
  Thirty one eyes of 17 patients were included. Thirteen eyes were treated for acute disease but progressed to stage 4 or 5; seven had cryotherapy and six diode laser photocoagulation. Cataract was found in 17 eyes (54.8%), glaucoma in seven eyes (22.6%), microphthalmos in 15 (48.4%), and corneal opacification in four eyes (12.9%). Fifteen eyes had surgical procedures; two (6.5%) had trabeculectomy, four (12.9%) had lensectomy, and nine (29%) retinal detachment repair. Transferred infants had their initial eye examination later than infants in hospitals screened by the authors and 80% of them had progressed beyond threshold ROP by the time they were transferred for treatment. Twenty nine eyes (93.6%) had visual acuities of 3/60 or less and only two eyes (6.5%) achieved 6/18 or less.
  
  
  CONCLUSIONS
  The visual outcome of the eyes undergoing retinal re-attachment surgery was disappointing. Cataract, microphthalmos, and glaucoma were the most frequent complications, and surgical intervention was often required. The need for children who are blind as a result of ROP to have long term follow up is shown.
authors.affiliation: Children's Hospital, Dublin, Ireland.
authors.forename: D M
authors.initials: DM
authors.lastname: Knight-Nanan
authors.forename: K
authors.initials: K
authors.lastname: Algawi
authors.forename: R
authors.initials: R
authors.lastname: Bowell
authors.forename: M
authors.initials: M
authors.lastname: O'Keefe
mesh_terms: D002386:Cataract / Q000150:complications; D002387:Cataract Extraction; D017679:Cryotherapy; D018450:Disease Progression; D005901:Glaucoma / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008028:Light Coagulation; D008850:Microphthalmos / Q000150:complications; D012017:Referral and Consultation; D012178:Retinopathy of Prematurity / Q000150:complications* / Q000628:therapy*; D014130:Trabeculectomy; D015351:Vision Screening; D014792:Visual Acuity