Treatment of Helicobacter pylori infection by topical administration of antimicrobial agents.
A technique has been developed in which a combination of bismuth subnitrate, amoxycillin and metronidazole is instilled into the stomach via a nasogastric tube and removed after 1 hour, thereby avoiding the side-effects often seen with triple therapy. This technique has achieved eradication of H. pylori in 24 of 25 patients with non-ulcer dyspepsia. A modified version of the technique was used in six patients, and eradication achieved in each case.
Satoh
K
K
Dept. of Gastroenterology, Jichi Medical School, Tochigi, Japan.
D000287:Administration, Topical; D000658:Amoxicillin / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D001729:Bismuth / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D007441:Intubation, Gastrointestinal; D008795:Metronidazole / Q000008:administration & dosage*; D010406:Penicillins / Q000008:administration & dosage*
D000863:Antacids; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin; C010804:bismuth subnitrate; D001729:Bismuth