[Transsphenoidal microsurgical removal of GH-secreting pituitary adenoma in: a report of 200 cases].
From July 1979 to April 1992, 212 cases of GH-secreting pituitary adenoma were treated transsphenoidally by microsurgical technique, of whom two hundred cases monitored with their GH levels at preoperative and postoperative periods. The majority of cases totally 132 cases were of macroadenoma, and 68 cases were of microadenoma. 138 cases were operated on after April 1986. The cure and remission rate averaged to 72.5%, rising from 44.4% (before 1986) to 80.5% for microadenoma and from 31.4% to 69.1% for macroadenoma due to improvement of technique and accumulation of experience. One patient died of angiocardiopathy suddenly during operation. Mortality rate was 0.5%. The follow-up observation of postoperative GH levels in 52 cases revealed that the GH levels within 2 weeks after operation were the same as in 3-6 months. It is thought that the early GH levels may represent the surgical results. The surgical technique is described and factors influencing the surgical results, prevention and treatment of operative complications are discussed in this paper.
Su
C
C
PUMC Hospital, CAMS and PUMC, Beijing.
Ren
Z
Z
Wang
W
W
Yin
Z
Z
Wang
R
R
D000239:Adenoma, Acidophil / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010673:Pheochromocytoma / Q000097:blood / Q000378:metabolism / Q000601:surgery; D010911:Pituitary Neoplasms / Q000097:blood / Q000378:metabolism / Q000601:surgery*
D013006:Growth Hormone