title: A computer heart model incorporating anisotropic propagation. III. Simulation of ectopic beats.
abstract: With the advent of catheter ablation procedures, it has become an important goal to predict noninvasively the site of origin of ventricular tachycardia. Site classifications based on the observed body surface potential maps (BSPMs) during ventricular endocardial pacing, as well as on the patterns of the QRS integrals of these maps, have been suggested. The goals of this study were to verify these maps and their QRS integral patterns via simulation using a computer heart model with realistic geometry and to determine whether the model could improve clinical understanding of these ectopic patterns. Simulation was achieved by initiating excitation of the heart model at different endocardial sites and their overlying epicardial counterparts. This excitation propagated in anisotropic fashion in the myocardium. Retrograde excitation of the model's His-Purkinje conduction system was necessary to obtain realistic activation durations. Simulated BSPMs, computed by placing the heart model inside a numerical torso model, and their QRS integrals were close to those observed clinically. Small differences in QRS integral map patterns and in the positions of the QRS integral map extrema were noted for endocardial sites in the left septal and anteroseptal regions. The simulated BSPMs during early QRS for an endocardial site and its epicardial counterpart tended to be mirror images about the zero isopotential contour, exchanging positive and negative map regions. The simulation results attest to the model's ability to reproduce accurately clinically recorded body surface potential distributions obtained following endocardial stimulation. The QRS integral maps from endocardial sites in the left septal and anteroseptal regions were the most labile, owing to considerable cancellation effects. Conventional BSPMs can be useful to help distinguish between endocardial and epicardial ectopic sites.
authors.affiliation: Research Center, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.
authors.forename: Z
authors.initials: Z
authors.lastname: Xu
authors.forename: R M
authors.initials: RM
authors.lastname: Gulrajani
authors.forename: F
authors.initials: F
authors.lastname: Molin
authors.forename: M
authors.initials: M
authors.lastname: Lorange
authors.forename: B
authors.initials: B
authors.lastname: Dubé
authors.forename: P
authors.initials: P
authors.lastname: Savard
authors.forename: R A
authors.initials: RA
authors.lastname: Nadeau
mesh_terms: D016880:Anisotropy; D018780:Body Surface Potential Mapping; D003198:Computer Simulation; D004699:Endocardium / Q000502:physiology; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D010496:Pericardium / Q000502:physiology; D017180:Tachycardia, Ventricular / Q000503:physiopathology*