title: [Analysis of HLA-DRB1 alleles in patients with IDDM].
abstract: HLA-DR association with IDDM in local population in Beijing was studied by PCR/SSP typing. The frequency of HLA-DR9 was significantly higher in diabetic patients (30.3% [45/148] vs 17.92% [38/212], chi 2 = 6.97, P < 8.3 x 10(-3)). DR3 was higher in diabetic patients in this study (7.0% [10/148] vs 2.36% [5/212], chi 2 = 3.19, P > 0.05) and DR2 was lower in patients with IDDM (7.4% [11/148] vs 19.8% [42/212], chi 2 = 9.67, P < 1.9 x 10(-3)). These results suggest that DR9 and DR3 both were positively associated with IDDM, but DR2 was negatively associated with IDDM.
authors.affiliation: Beijing Tuberculosis and Thoracic Tumor Research Institute.
authors.forename: C
authors.initials: C
authors.lastname: Song
authors.forename: C
authors.initials: C
authors.lastname: Qiu
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: H
authors.initials: H
authors.lastname: Meng
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004198:Disease Susceptibility; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D015802:HLA-DR2 Antigen / Q000235:genetics; D015803:HLA-DR3 Antigen / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D016133:Polymerase Chain Reaction
chemical_list: D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; C038988:HLA-DR9 antigen; D059811:HLA-DRB1 Chains