title: Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease.
abstract: Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.
authors.affiliation: Dept of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495, USA. stracy@molbio.unmc.edu
authors.forename: S
authors.initials: S
authors.lastname: Tracy
authors.forename: N M
authors.initials: NM
authors.lastname: Chapman
authors.forename: J
authors.initials: J
authors.lastname: Romero
authors.forename: A I
authors.initials: AI
authors.lastname: Ramsingh
mesh_terms: D000368:Aged; D000818:Animals; D001483:Base Sequence; D002311:Cardiomyopathy, Dilated / Q000821:virology*; D003384:Coxsackievirus Infections / Q000821:virology*; D029822:Enterovirus B, Human / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009205:Myocarditis / Q000821:virology*; D014774:Virulence