[Ion channels in non excitable cells].
Several distinct types of voltage-gated and second-messenger-operated K+, Ca2+, Na+ and Cl- channels exist in electrically non excitable cells such as those of the hematopoietic lineage. In these cells ion channels mediate cellular functions involving intracellular biochemical responses, rather than rapid electrical signaling. The presence of the channels is required for several basic functions, such as activation, secretion of lymphokines, mitogenesis, the regulation of cell volume and the mechanisms of resistance to chemotherapeutic agents. Here IN we review the patch-clamp method for studying many characteristics of these ionic channels, particularly in blood cells.
Bertrán
G C
GC
Facutad de Medicina, Universidad de Buenos Aires, Argentina.
D'Alessio
C
C
Kotsias
B A
BA
D016718:Arachidonic Acid / Q000494:pharmacology; D002454:Cell Differentiation; D019008:Drug Resistance, Neoplasm; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D018408:Patch-Clamp Techniques
D007473:Ion Channels; D016718:Arachidonic Acid; D016173:Macrophage Colony-Stimulating Factor
Canales iónicos en células no excitables.