Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid.
Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg valaciclovir, or 30 mL Maalox 65 min after valaciclovir administration, or 30 mL Maalox 30 min before valaciclovir. Acyclovir plasma concentrations and pharmacokinetic parameters were not significantly affected by administration of Maalox before or after valaciclovir. Therefore, there is no need for restriction of valaciclovir dosing in patients receiving antacid medication.
de Bony
F
F
Department of Clinical Pharmacology, Laboratoires Wellcome, Issy les Moulineaux, France.
Bidault
R
R
Peck
R
R
Posner
J
J
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000328:Adult; D000536:Aluminum Hydroxide / Q000493:pharmacokinetics / Q000494:pharmacology*; D000704:Analysis of Variance; D000863:Antacids / Q000493:pharmacokinetics / Q000494:pharmacology*; D000998:Antiviral Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008276:Magnesium Hydroxide / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D011355:Prodrugs / Q000493:pharmacokinetics / Q000494:pharmacology*; D012016:Reference Values; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
D000863:Antacids; D000998:Antiviral Agents; D004338:Drug Combinations; D011355:Prodrugs; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D014633:Valine; D000077483:Valacyclovir; D008276:Magnesium Hydroxide; D000212:Acyclovir