[Intracoronary isosorbide mononitrate versus placebo. A double-blind study with quantitative coronary angiography].
OBJECTIVE
To evaluate the vasodilation effect of intracoronary isosorbide mononitrate (ISMN) on the coronary arteries, systolic aortic pressure (SAP) and cardiac rhythms.


METHODS
Forty patients aged 61 (40-72) years, 30 (75%) male, were randomized to receive on a double blind fashion, 20 mg of ISMN or placebo. The two groups had similar baseline characteristics. Quantitative coronary arteriography [by cardiovascular measurement system (CMS)] and SAP were compared before and after ISMN. We also observed the cardiac rhythm.


RESULTS
There were no arrhythmias. Reference vessel diameter increased from 2.6 +/- 0.5 mm before to 2.9 +/- 0.4 mm after ISMN and did not change, mean 2.9 +/- 0.5 mm, before and after placebo. There was a difference between ISMN and placebo (p < 0.0001). There was no difference in the SAP change between the two groups, 4.2 +/- 0.7 mmHg with ISMN and 1.8 +/- 0.5 mmHg with placebo (p = NS).


CONCLUSIONS
ISMN promotes a safe and effective vasodilation of the coronary arteries with no major effects in cardiac rhythm and systolic aortic pressure.
Vieira Botelho
R
R
Instituto Dante Pazzanese de Cardiologia, São Paulo.
Feres
F
F
São Thiago
L E
LE
Abud
R
R
Carneiro
J K
JK
Pinto
I
I
Rego Sousa
A G
AG
Rego Sousa
J E
JE
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
Mononitrato de isossorbida intracoronário versus placebo. Estudo duplo-cego através da angiografia coronária quantitativa.