title: Hyperoxia improves contrast sensitivity in early diabetic retinopathy.
abstract: OBJECTIVE
  The cause of vascular and visual pathology in diabetic retinopathy remains unknown. If retinal hypoxia plays a role, then early in the course of diabetes 100% oxygen breathing should normalise both contrast sensitivity and retinal blood flow.
  
  
  METHODS
  This hypothesis was tested in 12 diabetic patients with minimal retinopathy who, none the less, exhibited reduced contrast sensitivity (p = 0.003 versus 12 age and sex-matched controls) and prolonged retinal arteriovenous dye transit (p = 0.0001 versus controls).
  
  
  RESULTS
  Isocapnic hyperoxia failed to alter contrast sensitivity in controls, while it significantly improved contrast sensitivity in patients (at 12 cpd; p = 0.042) to levels indistinguishable from normal. Individual improvement in contrast sensitivity correlated positively with the severity of the initial defect (r = +0.84, p = 0.0008). Hyperoxia also had haemodynamic effects; it slowed retinal arteriovenous passage of fluorescein dye in controls, but did not further slow this transit time in patients.
  
  
  CONCLUSIONS
  These results demonstrate the reversibility of early contrast sensitivity deficits in diabetes mellitus, and support the hypothesis that factors linked to tissue hypoxia initiate both visual and vascular dysfunction in diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: O
authors.initials: O
authors.lastname: Arend
authors.forename: R P
authors.initials: RP
authors.lastname: Danis
authors.forename: D
authors.initials: D
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Wolf
authors.forename: B J
authors.initials: BJ
authors.lastname: Martin
mesh_terms: D000328:Adult; D000388:Air; D016022:Case-Control Studies; D015350:Contrast Sensitivity / Q000502:physiology*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications; D008297:Male; D010100:Oxygen / Q000627:therapeutic use*; D012171:Retinal Vessels / Q000502:physiology*
chemical_list: D010100:Oxygen