A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression.
Mechanisms of cancer prevention were studied using structurally different cancer-preventive agents, sarcophytol A, canventol, (-)-epigallo-catechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor alpha (TNF-alpha) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF-alpha mRNA expression and TNF-alpha release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c-jun, junB, c-fos, and fosB) was enhanced. These results strongly suggest that inhibition of TNF-alpha mRNA expression and its release is a new process of cancer prevention.
Suganuma
M
M
Saitama Cancer Center Research Institute, Japan.
Okabe
S
S
Sueoka
E
E
Iida
N
N
Komori
A
A
Kim
S J
SJ
Fujiki
H
H
D016475:3T3 Cells; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001483:Base Sequence; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D003511:Cyclohexanols / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011519:Proto-Oncogenes / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
D016588:Anticarcinogenic Agents; D003511:Cyclohexanols; D004224:Diterpenes; D014409:Tumor Necrosis Factor-alpha; D013629:Tamoxifen; C082453:canventol; C058761:sarcophytol A; D002392:Catechin; C045651:epigallocatechin gallate