[The effect of lithium derivatives of GABA on blood circulation and metabolic indices in the brain under ischemia].
In acute experiments on anesthetized cats with cerebral ischemia in conditions of autohemoperfusion of cerebral and peripheral vessels with a stable volume of blood we found that lithium oxybutirate and new GABA derivatives: LOS 1-84 and LOS 5-79 affect the cerebral blood flow and metabolism in the brain. Prophylactic intravenous injection of lithium oxybutirate did not affect the development of postischemic hyperperfusion but inhibited postischemic hyperperfusion. The compounds prevent the development of postischemic phenomena and promote the recovery of metabolism in the brain.
Pogorelyĭ
V E
VE
Gaevyĭ
M D
MD
Migruev
R R
RR
Ivashev
M N
MN
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006885:Hydroxybutyrates / Q000494:pharmacology* / Q000627:therapeutic use; D008094:Lithium / Q000494:pharmacology* / Q000627:therapeutic use; D018020:Lithium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use
D006885:Hydroxybutyrates; D018020:Lithium Compounds; D009942:Organometallic Compounds; D005680:gamma-Aminobutyric Acid; C022826:lithium hydroxybutyrate; D008094:Lithium
Vliianie litievykh proizvodnykh GAMK na krovoobrashchenie i nekotorye pokazateli metabolizma v golovnom mozge v usloviiakh ishemii.