title: [Lipid changes of fibrinogen and of platelet aggregation induced by etofibrate].
abstract: OBJECTIVE
  To evaluate modifications on lipid profile, fibrinogen and platelet aggregation induced by etofibrate.
  
  
  METHODS
  Twenty-one adult patients were studied. They all had primary hyperlipidemia and had already been on the AHA step I diet and placebo. Etofibrate (500mg/day) was administered for 60 days in the active phase, when lipid parameters, fibrinogen and platelet aggregation were measured.
  
  
  RESULTS
  The % significant reductions were: total cholesterol (-9.50%), LDL-cholesterol (-7.88%), triglycerides (-19.07%), total cholesterol/HDL-cholesterol(-11.90%), LDL-cholesterol/HDL-cholesterol (-10.20%), fibrinogen (-12.79%), platelet aggregation with adrenaline (-24.02%), with ADP 1 mumol (-30.13%), and ADP 3 mumol (-24.51%).
  
  
  CONCLUSIONS
  The beneficial effects of etofibrate were observed not only on the lipid profile but also on the thrombogenic parameters measured by fibrinogen and platelet aggregation.
authors.affiliation: Escola Paulista de Medicina-UNIFESP, Sö Paulo.
authors.forename: F A
authors.initials: FA
authors.lastname: Fonseca
authors.forename: J P
authors.initials: JP
authors.lastname: Novazzi
authors.forename: M S
authors.initials: MS
authors.lastname: Cendoroglo
authors.forename: M
authors.initials: M
authors.lastname: Duarte
authors.forename: L E
authors.initials: LE
authors.lastname: Almeida Pinto
authors.forename: L M
authors.initials: LM
authors.lastname: Rabelo
authors.forename: T L
authors.initials: TL
authors.lastname: da Rocha Martinez
mesh_terms: D000328:Adult; D002995:Clofibric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D008074:Lipoproteins; C009746:etofibrate; D002995:Clofibric Acid; D005340:Fibrinogen
vernacular_title: Modificações lipídicas do fibrinogênio e da agregação plaqutária induzidas pelo etofibrato.