title: Twenty-four-hour intragastric acidity following early evening or bedtime administration of roxatidine in duodenal ulcer patients.
abstract: OBJECTIVE
  To assess the usefulness of early evening administration of roxatidine 150 mg as an alternative to the traditional bedtime regimen.
  
  
  METHODS
  Twenty-four patients with healed duodenal ulcer were dosed according to a balanced incomplete-block design, with two of the following regimens: placebo, roxatidine 150 mg at 07.30 h (early evening) or roxatidine 150 mg at 22.00 h (bedtime). Twenty-four-hour intragastric pH-metry was started at 18.00 h on the first day of dosing. Median pH was determined for the 24-h period, and for the following time intervals: 20.00-00.00 h, 00.00-08.00 h and 08.00-18.00 h. Percentage time in the 24-h period with pH greater than 4.0 was also calculated.
  
  
  RESULTS
  The two roxatidine regimens proved significantly superior to the placebo, decreasing 24-h acidity for all the time intervals, except the 20.00-00.00 h period, when mean intragastric pH with the early evening regimen (4.5 +/- 1.1) proved significantly higher than after placebo (2.2 +/- 1.0) or when roxatidine was taken at bedtime (2.4 +/- 1.1).
  
  
  CONCLUSIONS
  Early evening administration of roxatidine may afford satisfactory control of 24-h acidity, offering a useful alternative to conventional bedtime administration.
authors.affiliation: Gastrointestinal Unit, L. Sacco University Hospital, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lazzaroni
authors.forename: O
authors.initials: O
authors.lastname: Sangaletti
authors.forename: S
authors.initials: S
authors.lastname: Bargiggia
authors.forename: G
authors.initials: G
authors.lastname: Bensi
authors.forename: A
authors.initials: A
authors.lastname: Canali
authors.forename: G
authors.initials: G
authors.lastname: Bianchi Porro
mesh_terms: D000284:Administration, Oral; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D006635:Histamine H2 Antagonists; D010880:Piperidines; C053742:roxatidine acetate