[Clinical investigations of an i.m. combination anesthesia with fentanylclimazolam/xylazine and postoperative i.v. antagonism with naloxone/sarmazenil/yohimbine in guinea pigs].
Aim of the study was the clinical use of a completely antagonisable anaesthesia in guinea pigs. The dosage based on experimental studies. Fentanyl, climazolam and xylazine (0.05/2.0/2.0 mg/kg) were injected i.m. for combination anaesthesia and naloxone, sarmazenil and yohimbine (0.03/0.3/2.0 mg/kg) i.v. were used for antagonisation. 18 guinea pigs (17 female, one male) with an average body weight of 1177 g aged between eight months and five years were anaesthetised for various surgical procedures. The following clinical parameters were measured: body temperature, muscle relaxation, analgesia, hyperacusia, righting-, interdigital- and palpebral reflex. After antagonisation the return of righting reflex, the appearance of muscle trembling, the first walking without ataxia and the first food uptake were observed. The investigations showed that this kind of anaesthesia is suitable for surgical procedures in the guinea pig and is very safe because of the complete antagonisation of the depressing respiratory and circulatory effects of anaesthesia.
Henke
J
J
Institut für Experimentelle Chirurgie der TU, München.
Roberts
U
U
Otto
K
K
Lendl
C
C
Matis
U
U
Brill
T
T
Erhardt
W
W
D000768:Anesthesia, General / Q000379:methods / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D007093:Imidazoles / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D009270:Naloxone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D014991:Xylazine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D015016:Yohimbine / Q000008:administration & dosage*
D018686:Anesthetics, Intravenous; D014151:Anti-Anxiety Agents; D004338:Drug Combinations; D007093:Imidazoles; D009292:Narcotic Antagonists; D001569:Benzodiazepines; D014991:Xylazine; D015016:Yohimbine; D009270:Naloxone; C102747:sarmazenil; C035147:climazolam; D008874:Midazolam; D005283:Fentanyl
Klinische Untersuchungen zur i.m. Kombinationsanästhesie mit Fentanyl/Climazolam/Xylazin und postoperativer i.v. Antagonisierung mit Naloxon/Sarmazenil/Yohimbin beim Meerschweinchen.