title: Salicylate-induced changes in auditory thresholds of adolescent and adult rats.
abstract: Shifts in auditory intensity thresholds after salicylate administration were examined in postweanling and adult pigmented rats at frequencies ranging from 1 to 35 kHz. A total of 132 subjects from both age levels were tested under two-way active avoidance or one-way active avoidance paradigms. Estimated thresholds were inferred from behavioral responses to presentations of descending and ascending series of intensities for each test frequency value. Reliable threshold estimates were found under both avoidance conditioning methods, and compared to controls, subjects at both age levels showed threshold shifts at selective higher frequency values after salicylate injection, and the extent of shifts was related to salicylate dose level.
authors.affiliation: Department of Psychology, University of Massachusetts at Boston, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Brennan
authors.forename: C A
authors.initials: CA
authors.lastname: Brown
authors.forename: P J
authors.initials: PJ
authors.lastname: Jastreboff
mesh_terms: D000161:Acoustic Stimulation; D000375:Aging / Q000502:physiology*; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects* / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000502:physiology; D008144:Loudness Perception / Q000187:drug effects / Q000502:physiology; D008297:Male; D010897:Pitch Discrimination / Q000187:drug effects; D051381:Rats; D012459:Salicylates / Q000633:toxicity*; D020156:Salicylic Acid
chemical_list: D012459:Salicylates; D020156:Salicylic Acid