Low incidence of serotonin-induced occlusive coronary artery spasm in patients with recent myocardial infarction.
Intracoronary infusion of serotonin has been reported to induce varying degrees of coronary vasoconstriction in different coronary syndromes, but it has never been studied in patients after myocardial infarction. In patients with recent myocardial infarction, we found a low incidence (11%) of serotonin-induced occlusive spasm only in the infarct-related artery (IRA), and a significantly higher vasoconstriction in the distal segment of the IRA than in the same segment of the non-IRA.
Mongiardo
R
R
Institute of Cardiology, Catholic University of Rome, Italy.
Finocchiaro
M L
ML
Beltrame
J
J
Pristipino
C
C
Lombardo
A
A
Cianflone
D
D
Mazzari
M A
MA
Maseri
A
A
D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
D014665:Vasodilator Agents; D012701:Serotonin; D007548:Isosorbide Dinitrate