title: Long-term clinical outcome of post-cholecystectomy patients with biliary-type pain: results of manometry, non-invasive techniques and endoscopic sphincterotomy.
abstract: OBJECTIVE
  The purpose of the present study was to investigate prospectively the value of manometry, non-invasive techniques and endoscopic sphincterotomy in biliary type II and III patients with suspected sphincter of Oddi dysfunction.
  
  
  METHODS
  All patients (n = 31) had undergone a cholecystectomy from 1 to 45 years before entry into the study, and had a history of biliary-type pain ranging from 4 to 156 months. In a primary diagnostic work-up, including ERCP, other causes of gastrointestinal disease were excluded. The width of the common bile duct, pain induced by the injection of contrast medium into the common bile duct, delayed contrast drainage and the results of a morphine-neostigmine test were analysed. Manometric measurements of basal sphincter of Oddi pressure were performed. Twenty-three patients with an elevated basal pressure (> 40 mmHg) underwent endoscopic sphincterotomy.
  
  
  RESULTS
  During the follow-up period (8-62 months) 83% of the patients became symptom free or experienced an improvement. Basal sphincter of Oddi pressure and long-term clinical outcome of patients correlated to different degrees with the results of non-invasive techniques.
  
  
  CONCLUSIONS
  Our data suggest that endoscopic sphincterotomy may be an effective therapeutic modality in group II and III patients with sphincter of Oddi dysfunction in whom other gastrointestinal disorders have previously been excluded.
authors.affiliation: Department of Internal Medicine and Gastroenterology, Community and Academic Teaching Hospital, University of Cologne, Solingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Bozkurt
authors.forename: K H
authors.initials: KH
authors.lastname: Orth
authors.forename: B
authors.initials: B
authors.lastname: Butsch
authors.forename: G
authors.initials: G
authors.lastname: Lux
mesh_terms: D000328:Adult; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002763:Cholecystectomy; D002800:Cholinesterase Inhibitors; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D003137:Common Bile Duct Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008137:Longitudinal Studies; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009020:Morphine; D009294:Narcotics; D009388:Neostigmine; D010146:Pain; D011312:Pressure; D011446:Prospective Studies; D009803:Sphincter of Oddi / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D016717:Sphincterotomy, Endoscopic; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors; D003287:Contrast Media; D009294:Narcotics; D009388:Neostigmine; D009020:Morphine