Evaluation of the efficacy of oral cromolyn sodium or an oligoantigenic diet in children with atopic dermatitis: a multicenter study of 1085 patients.
One thousand eighty-five children with atopic dermatitis were enrolled in a multicenter study to evaluate the efficacy of 4 weeks of oral sodium cromoglycate or 4 weeks of a restricted diet. One thousand-eleven children (93%) concluded the study. At the end of the trial there was a significant improvement in skin lesions in the two groups: 61% of the patients in the sodium cromoglycate group and 69% in the restricted diet showed a significant improvement in atopic dermatitis. We concluded that, at least in our experimental design, both sodium cromoglycate and a restricted diet are equally effective in atopic dermatitis.
Businco
L
L
Ped. Dpt., La Sapienza University of Rome, Italy.
Meglio
P
P
Amato
G
G
Balsamo
V
V
Cainelli
T
T
Cantone
P
P
Castro
M
M
Coletta
A
A
Corrias
A
A
Giorgi
P L
PL
Grazioli
I
I
Longo-Papadia
L
L
Marcucci
F
F
Masi
M
M
Pavesio
D
D
Scotta
S
S
Seidenari
S
S
Vierucci
A
A
D000284:Administration, Oral; D000293:Adolescent; D000941:Antigens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology*; D004032:Diet; D005512:Food Hypersensitivity / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007223:Infant
D000941:Antigens; D004205:Cromolyn Sodium