Propofol permits tracheal intubation but does not affect postoperative myalgias.
OBJECTIVE
To determine the effect of propofol without succinylcholine on intubating conditions and postoperative myalgias in ambulatory surgical patients undergoing general anesthesia.


METHODS
Prospective, double-blind, randomized study.


METHODS
Ambulatory surgery adult patients.


METHODS
56 ASA physical status I and II adult patients undergoing general endotracheal anesthesia.


METHODS
Group 1 patients received thiamylal plus succinylcholine, Group 2 patients received propofol plus succinylcholine; and Group 3 patients received propofol plus saline. All patients received fentanyl, lidocaine, and nitrous oxide plus isoflurane in oxygen.


RESULTS
Incidence and severity of fasciculations, tracheal intubating conditions, and myalgias on the first and third postoperative days were measured. Propofol did not affect the incidence or severity of fasciculations following succinylcholine, or the incidence of myalgias. Of patients who received propofol without succinylcholine, intubation was successful in 85%.


CONCLUSIONS
Propofol did not affect the incidence or severity of postoperative myalgias following succinylcholine.
Mingus
M L
ML
Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York, USA.
Shamsi
A K
AK
Recant
J F
JF
Eisenkraft
J B
JB
D000328:Adult; D000556:Ambulatory Surgical Procedures; D018686:Anesthetics, Intravenous; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009135:Muscular Diseases / Q000517:prevention & control*; D009467:Neuromuscular Depolarizing Agents / Q000627:therapeutic use; D010149:Postoperative Pain / Q000517:prevention & control*; D015742:Propofol; D011446:Prospective Studies; D013390:Succinylcholine / Q000627:therapeutic use
D018686:Anesthetics, Intravenous; D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine; D015742:Propofol