title: Influence of sodium pentosan polysulphate and certain inhibitors on calcium oxalate crystal growth.
abstract: Calcium oxalate crystal growth and aggregation leads to the formation of renal calculi. It is known to be inhibited by several compounds both in vitro and in vivo conditions. The present study highlights the inhibitory potential of sodium pentosan polysulphate (SPP), a semi-synthetic glycosaminoglycan (GAG) on calcium oxalate crystal growth in vitro. Its efficacy was compared with those of known inhibitors like pyrophosphate, heparin and chondroitin-4-sulphate. Of the above compounds pyrophosphate was found to be the most potent inhibitor. Among the GAGs, SPP exhibited 80% inhibitory activity as compared to heparin. A lesser degree of inhibition was observed with chondroitin-4-sulphate.
authors.affiliation: Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, India.
authors.forename: D
authors.initials: D
authors.lastname: Senthil
authors.forename: K
authors.initials: K
authors.lastname: Subha
authors.forename: N
authors.initials: N
authors.lastname: Saravanan
authors.forename: P
authors.initials: P
authors.lastname: Varalakshmi
mesh_terms: D002129:Calcium Oxalate / Q000737:chemistry*; D002809:Chondroitin Sulfates / Q000494:pharmacology; D003460:Crystallization; D003864:Depression, Chemical; D011756:Diphosphates / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D014545:Urinary Calculi / Q000517:prevention & control
chemical_list: D011756:Diphosphates; D002129:Calcium Oxalate; D010426:Pentosan Sulfuric Polyester; D006493:Heparin; D002809:Chondroitin Sulfates