[The toxicological characteristics of the interaction of cholinolytics with aminostigmine--a new reversible cholinesterase inhibitor].
This investigation has been carried out on albino mice. In the first series of experiments, we determined the dependence of LD50 of aminostigmine on different doses of 10 cholinolytics, and conversely, the dependence of LD50 of cholinolytics on aminostigmine administration. The initial slopes of the dose-effect curves were calculated. This data form the basis for evaluation of the character and degree of interactions. We established that benactyzine, spasmolytin, ftoracizin, arpenal, atropine, ganglerone, and methacin at low doses exhibit antagonism (with decreasing activity), whereas at high doses they exhibit synergism to the toxic effect of aminostigmine. In the interaction with aminostigmine, pirenzepine and amitriptyline (M1--cholinolytics) reveal a slightly pronounced antagonism, whereas aetyrophene, a selective central N-cholinolytic, displays mutual synergism. In the second series of experiments we showed that a combination of M1-, M2-cholinolytic atropine with M1- cholinolytics does not change the efficacy of the prophylaxis of aminostigmine and physostigmine poisoning, whereas a combination with N-cholinolytic increases it.
Prozorovskiĭ
V B
VB
Sazonova
A V
AV
D000818:Animals; D002219:Carbamates; D018680:Cholinergic Antagonists / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000506:poisoning / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011041:Poisoning / Q000188:drug therapy / Q000517:prevention & control; D011725:Pyridines; D011729:Pyridostigmine Bromide / Q000031:analogs & derivatives; D012378:Rodenticides / Q000494:pharmacology / Q000506:poisoning / Q000633:toxicity*
D002219:Carbamates; D018680:Cholinergic Antagonists; D002800:Cholinesterase Inhibitors; D011725:Pyridines; D012378:Rodenticides; C070102:aminostigmine; D011729:Pyridostigmine Bromide
Toksikologicheskaia kharakteristika vzaimovliianiia kholinolitikov s aminostigminom--novym obratimym ingibitorom kholinesterazy.