title: A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity.
abstract: Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.
authors.affiliation: Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: H
authors.initials: H
authors.lastname: Kang
authors.forename: E M
authors.initials: EM
authors.lastname: Schuman
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001369:Axons / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor; D002701:Chloramphenicol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003712:Dendrites / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009473:Neuronal Plasticity; D020933:Neurotrophin 3; D014176:Protein Biosynthesis; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D017966:Pyramidal Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3; D011500:Protein Synthesis Inhibitors; D002701:Chloramphenicol; D000841:Anisomycin; D003513:Cycloheximide