Antimalarial properties of soy-bean fat emulsions.
Intralipid and Ivelip are commercial preparations of soy-bean lipid extracts used for intravenous supplementation of lipids in various clinical conditions. They were found to inhibit the growth of Plasmodium falciparum in culture with an IC50 of 8.07 +/- 2.13 and 13.32 +/- 2.05 mg.ml-1, respectively. Intralipid rapidly and efficiently inhibited nucleic acid synthesis in cultured P. falciparum, exhibiting full inhibitory activity in less than 2 h. Ivelip injected intraperitoneally, was found by the 4-day suppressive test to be active in vivo against P. vinckei petteri within the normal recommended regimen for dietary lipid supply (0.5-4 g.kg-1), but it was impossible to obtain a radical cure even with very high doses (6.4 g.kg-1). Ivelip was less effective against P. berghei and P. yoelii nigeriensis. As Ivelip showed no interference with the antimalarial activity of chloroquine, it could be considered for use in the treatment of severe human malaria in association with 4-aminoquinolines to expedite the clearance of parasites.
Deharo
E
E
Laboratoire de Biologie Parasitaire associé au CNRS, (URA 114), Muséum National d'Histoire Naturelle, Paris, France.
Krugliak
M
M
Baccam
D
D
Ginsburg
H
H
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology*; D002738:Chloroquine / Q000008:administration & dosage; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D009696:Nucleic Acids / Q000096:biosynthesis; D018384:Oxidative Stress; D010961:Plasmodium / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D010967:Plasmodium yoelii / Q000187:drug effects; D013025:Glycine max
D000962:Antimalarials; D005217:Fat Emulsions, Intravenous; D009696:Nucleic Acids; D002738:Chloroquine