title: Non-islet-cell tumour induced hypoglycaemia: a case report and review of literature.
abstract: A 54-year-old man presented with a poorly differentiated adenocarcinoma of the rectum with multiple metastases to the liver. During hospitalization the patient developed periods of hypoglycaemia due to production of "big" IGF-II by the tumour. Possible pathophysiological mechanisms of non-islet-cell tumour-induced hypoglycaemia are discussed.
authors.affiliation: Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, Netherlands.
authors.forename: B C
authors.initials: BC
authors.lastname: Kuenen
authors.forename: J
authors.initials: J
authors.lastname: van Doorn
authors.forename: P H
authors.initials: PH
authors.lastname: Slee
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000503:physiopathology / Q000556:secondary; D017809:Fatal Outcome; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D008113:Liver Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology / Q000503:physiopathology
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II