title: [Investigation of the impurity profile of nifedipine by LC/MS].
abstract: The manufacture-characteristic impurity profile of nifedipine drug substance was studied by HPLC and on-line LC/MS coupling. Using a new gradient HPLC procedure and MS detection, spectroscopic evidences for the chemical structure of some previously unknown minor impurities (all under 0.1%) were obtained.
authors.forename: T
authors.initials: T
authors.lastname: Karancsi
authors.forename: E
authors.initials: E
authors.lastname: Karaffa
authors.forename: L
authors.initials: L
authors.lastname: Ladányi
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D009543:Nifedipine / Q000737:chemistry / Q000302:isolation & purification / Q000592:standards*
chemical_list: D009543:Nifedipine
vernacular_title: A nifedipin hatóanyag szennyezésprofiljának LC/MS vizsgálata.