[The modification of a radiation lesion with 9a-homo-13-thiaprostanoids].
The radioprotective properties of 12 compounds of 9a-homo-13-thiaprostanoid series were investigated under gamma irradiation using the molecular model of beta-carotene radio-oxidation in oleic acid in vitro, erythrocyte radiomimetic model in ex vivo-in vitro system as well as in vivo radiation damage in mice. Most of these compounds stimulated the radio-oxidation of beta-carotene, however in this model two prostanoids with natural alpha-chain displayed radioprotective properties. Expressed membrane stabilizing effect of two 9a-homo-13-thiaprostanoid nor-analogues was revealed in radiomimetic model experiments. Two 10, 10-dimethyl-13-thiaprostanoids raised animal radioresistance during in vivo experiments.
Kuz'mitskiĭ
B B
BB
Dad'kov
I G
IG
Golubeva
M B
MB
Nasek
V M
VM
Khlebnikova
T S
TS
Petrusevich
I I
II
Lakhvich
F A
FA
D000818:Animals; D002338:Carotenoids / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000528:radiation effects; D005260:Female; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D013329:Structure-Activity Relationship; D019207:beta Carotene
D011453:Prostaglandins; D011837:Radiation-Protective Agents; D019207:beta Carotene; D002338:Carotenoids
Modifikatsiia luchevogo porazheniia 9a-gomo-13-tiaprostanoidami.