Can cysteine direct tyrosine in signal transduction for environment-oriented gene control?
Signals are transduced from the cell surface to the nucleus through phosphorylation and dephosphorylation chain reactions of cellular proteins at tyrosine and serine/threonine. Recent evidence suggests that the signal generated through the protein modification at cysteine by oxidation/reduction crosstalks to the protein phosphorylation/dephosphorylation-linked one. I propose that the cysteine-oriented signal potentially directs the tyrosine-oriented one and this mechanism underlies the environment-oriented control of internal signaling for gene expression.
Nakashima
I
I
Department of Immunology, Nagoya University School of Medicine.
D000818:Animals; D003545:Cysteine / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology*; D014443:Tyrosine / Q000737:chemistry*
D014443:Tyrosine; D003545:Cysteine