A controlled trial of remacemide hydrochloride in Huntington's disease.
We conducted a randomized, double-blind, placebo-controlled tolerability study of a N-methyl-D-aspartate (NMDA) glutamate receptor ion-channel blocker, remacemide hydrochloride, in 31 independently ambulatory patients (18 men, 13 women) with Huntington's disease (HD). Subjects were randomized to receive either placebo or active remacemide at dosages of 200 mg/day or 600 mg/day. The primary outcome measure was the proportion of subjects able to complete the study with the assigned treatment. Remacemide was generally well tolerated, and no significant differences between the treatment arms were found in the primary outcome measure. A trend toward improvement in chorea was observed among subjects administered remacemide 200 mg/day. Based on the tolerability and safety demonstrated during this short-term trial, remacemide warrants more extended controlled investigation in patients with HD.
Kieburtz
K
K
Department of Neurology, University of Rochester Medical Center, New York 14642, USA.
Feigin
A
A
McDermott
M
M
Como
P
P
Abwender
D
D
Zimmerman
C
C
Hickey
C
C
Orme
C
C
Claude
K
K
Sotack
J
J
Greenamyre
J T
JT
Dunn
C
C
Shoulson
I
I
D000081:Acetamides / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D009483:Neuropsychological Tests; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis / Q000502:physiology; D016896:Treatment Outcome
D000081:Acetamides; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; C067553:remacemide