Antitumor activity of an alkylating derivative of dipyridamole.
Synthesis of 2,6-Bis[bis(2-chloroethyl)amino]-4,8-dipiperidino-pyrimido [5,4-d]pyrimidine (DIP-C1) was carried out, and the new derivative showed cytotoxic activity comparable to other alkylating drugs on cultured P388 leukaemia cells and HeLa cells. The present paper reports the effects of DIP-C1 on respiration of Ehrlich ascites tumor cells and on survival of the mice implanted with Ehrlich ascites tumor cells. The compound showed a significant activity in both experimental models.
Andreani
A
A
Dipartimento di Scienze Farmaceutiche dell'Università, Bologna, Italy.
Bossa
R
R
Fraccari
A
A
Galatulas
I
I
Ninci
M A
MA
Rambaldi
M
M
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism; D004176:Dipyridamole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D014407:Tumor Cells, Cultured
D018906:Antineoplastic Agents, Alkylating; C068429:2,6-bis(bis-(2-chloroethyl)amino)-4,8-dipiperidino-pyrimido(5,4-d)pyrimidine; D004176:Dipyridamole