[Neurospecific protein-hormonal complexes].
New cardioactive protein-hormone complexes (PHC) were identified, and then separated and purified in magnocellular foci of hypothalamus of oxen and some other animals. It was proved that the PHC are specific for nervous tissue, their subsell localisation was studied, concentration and distribution in an organism were identified. It was discovered, that under dissociation of PHC, its high-molecular "apoforms" represent new specific glicoproteins, and the low-molecular combinations related to them in a non-covalent way are glicopeptides with clear cardioactive properties inherent in the respective native PHC. The above glicoproteins are transport molecules for the cardioactive neurohormones of hypothalamus, and are the basis for mediation of the inter-neurone interaction and the finction of intracellular connection. In addition, it was proved that these glicoproteins can exist in the form of preprohormone forms of cardiotropic neurohormones of hypothalamus: "K", "S", and "G".
Srapionian
R M
RM
Institute of Biochemistry named after G.Kh. Buniatian of NAN of Armenia, Yerevan.
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006023:Glycoproteins / Q000502:physiology; D006321:Heart / Q000187:drug effects; D007028:Hypothalamic Hormones / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009928:Organ Specificity
D002352:Carrier Proteins; D006023:Glycoproteins; D007028:Hypothalamic Hormones; D009419:Nerve Tissue Proteins
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