V3 peptide binding pattern and HIV-1 transmission route in Rio de Janeiro.
To characterize antibody binding to a panel of V3 loop peptides representing diverse HIV-1 neutralization epitopes, 149 HIV-1 infected individuals from Rio de Janeiro (RJ) were investigated. Results were analyzed with respect to risk factors for infection and other epidemiological and clinical data. Peptide reactivity was not associated with sex, clinical status, CD4 counts, antigenemia or beta 2-microglobulin serum level. A segregation of peptide reactivity according to route of infection was encountered. This finding suggests that more then one viral strain may be circulating in RJ, in subjects with different risk factors for HIV-1 infection. An investigation of prevalent HIV-1 genotypes, serotypes and immunotypes may be of importance for the design and selection of potential vaccines to be used in Brazil as well as for the selection of populations to be included in future vaccine efficacy trials.
Pinto
M E
ME
Serviço de Doenças Infecciosas e Parasitárias, Universidade Federal do Rio de Janeiro, Brasil.
Schechter
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission*; D000940:Antigenic Variation / Q000276:immunology*; D001938:Brazil; D005838:Genotype; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology; D015488:HIV Antigens / Q000235:genetics; D006801:Humans; D010456:Peptides, Cyclic / Q000378:metabolism; D012307:Risk Factors
D015483:HIV Antibodies; D015488:HIV Antigens; D010456:Peptides, Cyclic