[Synthesis of substituted benzeneseleninic acid and its antineoplastic activity].
In view of the negative relationship between selenium and cancer, we designed and synthesized eleven substituted benzeneselenic acids (IVa-k) The antineoplastic activity of the title compounds was evaluated via the tests of inhibition of acetylcholinesterase, HL-60 and K562 in vitro, and Ehrlich carcinoma in mice. The result showed that the compounds IVa and IVb had distinct antineoplastic activity. The life span increase rate of IVb on mice bearing Ehrlich carcinoma was 20.30% (20mg/kg), which was higher than the increase rate of sodium selenite (10.65%, 0.5mg/kg).
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D051379:Mice; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D016566:Organoselenium Compounds; C101202:benzeneseleninic acid