Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys.
Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monkeys. In the present study, low doses of these two drugs, which were ineffective when given alone, significantly impaired performance when given in combination. Moreover, the effect was greater than additive, indicating a synergistic interaction. These results suggest that interactions between cholinergic and glutamatergic systems play an important role in regulation of visual recognition memory.
Matsuoka
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N
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, USA.
Aigner
T G
TG
D000818:Animals; D003071:Cognition / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D018698:Glutamic Acid / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008568:Memory / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010276:Parasympatholytics / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D010276:Parasympatholytics; D018698:Glutamic Acid; D016291:Dizocilpine Maleate; D012601:Scopolamine