title: Hyperpolarizing shift of the M-current activation curve after washout of muscarine in bullfrog sympathetic neurons.
abstract: The mechanism underlying the over-recovery of an M-type potassium current following the washout of muscarine (20 microM) has been examined. Whole-cell recordings were made from single neurons dissociated from bullfrog sympathetic ganglia. During over-recovery, the maximum M-conductance decreased by about 2.8 nS while the steady-state M-current activation curve was displaced in the hyperpolarizing direction by about 13 mV. These data suggest that a hyperpolarizing shift in the kinetics of M-current causes over-recovery in amphibian autonomic neurons.
authors.affiliation: Department of Physiology, Kurume University School of Medicine, Japan. tokimasa@is.icc.u-tokai.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Tokimasa
authors.forename: M A
authors.initials: MA
authors.lastname: Simmons
authors.forename: C R
authors.initials: CR
authors.lastname: Schneider
authors.forename: T
authors.initials: T
authors.lastname: Akasu
mesh_terms: D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D008564:Membrane Potentials / Q000502:physiology*; D009116:Muscarine / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects*; D011892:Rana catesbeiana; D013997:Time Factors
chemical_list: D015221:Potassium Channels; D009116:Muscarine