Comparison of the effects of propofol and halothane on acute myocardial ischaemia and myocardial reperfusion injury.
The effects of two blood concentrations of propofol on acute severe regional myocardial ischaemia (15-minute occlusion of the LAD coronary artery) and 2-hour reperfusion were studied in 10 pigs. Results were contrasted with the effect of 0.8% halothane (N = 5). Results indicate that during acute ischaemia, regional myocardial function of the segment supplied by the LAD artery was not protected against the effects of ischaemia in the propofol or halothane groups. During reperfusion, animals subjected to halothane demonstrated significantly fewer reperfusion arrhythmias and segmental function was less stunned than in either propofol group. There was no difference in heart performance between the propofol groups. Results indicate that the proposed anti-oxidant effect of propofol is not sufficient to protect the animal heart from reperfusion injury.
Coetzee
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A
Department of Anaesthesiology, University of Stellenbosch, Tygerberg, W. Cape.
D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use*; D006221:Halothane / Q000008:administration & dosage / Q000627:therapeutic use*; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy*; D013552:Swine
D018685:Anesthetics, Inhalation; D016166:Free Radical Scavengers; D006221:Halothane; D015742:Propofol