title: Prediction of calf mortality by use of tests for passive transfer of colostral immunoglobulin.
abstract: OBJECTIVE
  To examine the ability of several commonly used tests for evaluation of passive transfer of immunoglobulin to predict mortality in dairy replacement heifers.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  246 dairy replacement heifers between 1 and 8 days of age.
  
  
  METHODS
  Using serum samples obtained from each calf, total serum protein concentration and results of zinc sulfate turbidity, sodium sulfite turbidity, radial immunodiffusion, and glutaraldehyde coagulation were determined. Calves were monitored for 100 days, and relative risks for death were calculated. Logistic regression models predicting death also were developed.
  
  
  RESULTS
  None of the logistic regression models detected a significant association between test results and mortality. The greatest relative risks of mortality were observed in calves with serum protein concentrations < 4.5 g/dl, serum IgG1 concentrations < 500 mg/dl, and sodium sulfite test scores < 1+.
  
  
  CONCLUSIONS
  Calves with lower passive transfer values had increased risk of death; however, failure of passive transfer is not an infallible predictor of mortality.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164-6610, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Rea
authors.forename: J W
authors.initials: JW
authors.lastname: Tyler
authors.forename: D D
authors.initials: DD
authors.lastname: Hancock
authors.forename: T E
authors.initials: TE
authors.lastname: Besser
authors.forename: L
authors.initials: L
authors.lastname: Wilson
authors.forename: D S
authors.initials: DS
authors.lastname: Krytenberg
authors.forename: S G
authors.initials: SG
authors.lastname: Sanders
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000401:mortality*; D003126:Colostrum / Q000276:immunology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D007136:Immunoglobulins / Q000276:immunology*; D016015:Logistic Models; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001798:Blood Proteins; D007074:Immunoglobulin G; D007136:Immunoglobulins