title: Fungal infections in neutropenic patients. A 8-year prospective study.
abstract: In this paper we report a eight-year prospective study designed to further characterize incidence, epidemiology, specific syndromes, treatment and prognosis associated with fungal infections in neutropenic patients. During the study period 30 fungal infections were diagnosed in 30 patients among 313 episodes of fever and neutropenia (10%). There were 15 cases of candidiasis, 5 pulmonary aspergillosis, 3 sinusitis by Aspergillus fumigatus, 5 infections by Fusarium sp., one infection by Trichosporon sp., and one infection due to Rhodotorula rubra. Blood cultures were positive in 18 cases (60%). The predisposing factors for fungal infection in multivariate analysis were the presence of central venous catheter (p < 0.001), longer duration of profound (< 100/mm3) neutropenia (p < 0.001), the use of corticosteroids (p < 0.001), gram-positive bacteremia (p = 0.002) and younger age (p = 0.03). In multivariate analysis only recovery of the neutropenia (p < 0.001) was associated with good prognosis whereas the diagnosis of infection by Fusarium sp. (p = 0.006) was strongly associated with a poor outcome. The death rate was 43%. There was no statistically significant difference in the death rate between patients who did receive (52%) or did not receive (50%) antifungal treatment. Identifying patients at risk, specific syndromes and prognostic factors may help to reduce the high mortality associated with disseminated fungal infections in neutropenic patients.
authors.affiliation: Serviços de Hematologia, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: M
authors.initials: M
authors.lastname: Nucci
authors.forename: W
authors.initials: W
authors.lastname: Pulcheri
authors.forename: N
authors.initials: N
authors.lastname: Spector
authors.forename: A P
authors.initials: AP
authors.lastname: Bueno
authors.forename: P C
authors.initials: PC
authors.lastname: Bacha
authors.forename: M J
authors.initials: MJ
authors.lastname: Caiuby
authors.forename: A
authors.initials: A
authors.lastname: Derossi
authors.forename: R
authors.initials: R
authors.lastname: Costa
authors.forename: J C
authors.initials: JC
authors.lastname: Morais
authors.forename: H P
authors.initials: HP
authors.lastname: de Oliveira
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009181:Mycoses / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D009503:Neutropenia / Q000097:blood / Q000150:complications*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents