[Antibiotic bonding on arterial prostheses: a necessity].
The introduction of arterial grafts made of polyester impregnated with a protein network is an important advance. Besides preventing leakage, impregnation makes it possible to bind active molecules, particularly antibiotics. Rifampicin is one of the antibiotics with an activity spectrum adapted to micro-organisms involved in graft infections and with a particular affinity for the protein network impregnating certain grafts. Rifampicin's affinity for gelatine means that large amounts of the antibiotic can be bound simply by dipping the graft in an antibiotic solution. This technique has been shown to be useful for both prevention and treatment in an experimental model. These preliminary findings have led to a multicentric randomized European trial which has provided encouraging results showing a decrease in the overall and early infection rates.
Goeau-Brissonniere
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Service de Chirurgie Générale et Vasculaire, Hôpital Ambroise Paré, Boulogne.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D006801:Humans; D015337:Multicenter Studies as Topic; D011091:Polyesters; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic
D000900:Anti-Bacterial Agents; D011091:Polyesters
Fixation d'antibiotique sur les prothèses artérielles: une nécessité.