Inhibition of lung cancer proliferation by antisense cyclin D.
The growth and tumorigenicity of murine lung cancer cells transfected with an antisense cyclin D1 construct were evaluated in studies pertaining to mouse lung carcinogenesis. This antisense construct inhibited the expression of cyclin D in these cells, significantly reducing both their in vitro proliferation and tumorigenicity in nude mice relative to control cells. These data may have implications regarding the treatment of human neoplasms of aerodigestive tract origin that either overexpress the cyclin D oncogene or exhibit mutations that influence cell cycle progression via cyclin D-dependent mechanisms.
Schrump
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Department of Thoracic and Cardiovascular Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Chen
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Consoli
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D000818:Animals; D015152:Blotting, Northern; D002453:Cell Cycle; D002455:Cell Division / Q000187:drug effects; D056741:Cyclin D; D016213:Cyclins / Q000032:analysis / Q000187:drug effects* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D016160:Retinoblastoma Protein / Q000032:analysis; D013489:Suppression, Genetic; D014162:Transfection; D014407:Tumor Cells, Cultured; D014520:Urethane
D056741:Cyclin D; D016213:Cyclins; D016376:Oligonucleotides, Antisense; D016160:Retinoblastoma Protein; D014520:Urethane