title: [Intracoronary isosorbide mononitrate versus placebo. A double-blind study with quantitative coronary angiography].
abstract: OBJECTIVE
  To evaluate the vasodilation effect of intracoronary isosorbide mononitrate (ISMN) on the coronary arteries, systolic aortic pressure (SAP) and cardiac rhythms.
  
  
  METHODS
  Forty patients aged 61 (40-72) years, 30 (75%) male, were randomized to receive on a double blind fashion, 20 mg of ISMN or placebo. The two groups had similar baseline characteristics. Quantitative coronary arteriography [by cardiovascular measurement system (CMS)] and SAP were compared before and after ISMN. We also observed the cardiac rhythm.
  
  
  RESULTS
  There were no arrhythmias. Reference vessel diameter increased from 2.6 +/- 0.5 mm before to 2.9 +/- 0.4 mm after ISMN and did not change, mean 2.9 +/- 0.5 mm, before and after placebo. There was a difference between ISMN and placebo (p < 0.0001). There was no difference in the SAP change between the two groups, 4.2 +/- 0.7 mmHg with ISMN and 1.8 +/- 0.5 mmHg with placebo (p = NS).
  
  
  CONCLUSIONS
  ISMN promotes a safe and effective vasodilation of the coronary arteries with no major effects in cardiac rhythm and systolic aortic pressure.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia, São Paulo.
authors.forename: R
authors.initials: R
authors.lastname: Vieira Botelho
authors.forename: F
authors.initials: F
authors.lastname: Feres
authors.forename: L E
authors.initials: LE
authors.lastname: São Thiago
authors.forename: R
authors.initials: R
authors.lastname: Abud
authors.forename: J K
authors.initials: JK
authors.lastname: Carneiro
authors.forename: I
authors.initials: I
authors.lastname: Pinto
authors.forename: A G
authors.initials: AG
authors.lastname: Rego Sousa
authors.forename: J E
authors.initials: JE
authors.lastname: Rego Sousa
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
vernacular_title: Mononitrato de isossorbida intracoronário versus placebo. Estudo duplo-cego através da angiografia coronária quantitativa.