Biochemical and mitogenic properties of the heparin-binding growth factor HARP.
Heparin affin regulatory peptide (HARP), also called Pleiotrophin (PTN), is a polypeptide that displays a high affinity for heparin and that shares approximately 50% sequence homology with Midkine (MK). According to this structural homology, these two molecules constitute a new family of heparin-binding proteins. The biological properties of HARP and MK remain largely a subject of debate. Both proteins have been described as neurite outgrowth promoting agents whereas until recently the mitogenic activity has been controversial. The aim of this review is to summarize the information on HARP with special focus on the recent data relating to its mitogenic properties.
Laaroubi
K
K
Laboratoire de Recherche sur la Croissance Cellulaire, Université Paris Val de Marne, Créteil, France.
Vacherot
F
F
Delbé
J
J
Caruelle
D
D
Barritault
D
D
Courty
J
J
D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002874:Chromosome Mapping; D016207:Cytokines / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology; D006133:Growth Substances / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology; D006801:Humans; D008934:Mitogens / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D017978:Receptors, Growth Factor / Q000502:physiology; D011975:Receptors, Mitogen / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor
D002352:Carrier Proteins; D016207:Cytokines; D006133:Growth Substances; D008934:Mitogens; D012333:RNA, Messenger; D017978:Receptors, Growth Factor; D011975:Receptors, Mitogen; C066845:pleiotrophin; D040262:Receptors, Vascular Endothelial Growth Factor