Galanin--a neuropeptide with inhibitory actions.
1. Galanin is a 29 (in humans 30) amino acids long neuropeptide with mostly inhibitory, hyperpolarizing actions. 2. Differential structural requirements of truncated forms of galanin and differential agonist/antagonist behaviour of chimeric peptides, high affinity galanin receptor ligands suggest the presence of pharmacologically distinct galanin receptor subtypes. 3. The galanin receptor from human Bowes melanoma cell line--a member of G-protein coupled receptor superfamily--has been cloned. 4. Galanin acts via Gi/G(o) proteins inhibiting cAMP production, inositol phosphate turnover, opening K+ channels or closing Ca2+ channels.
Kask
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K
Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden.
Langel
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Bartfai
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D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology; D003001:Cloning, Molecular; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D019004:Galanin / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology*; D015870:Gene Expression; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D008959:Models, Neurological; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000502:physiology; D044088:Receptors, Galanin; D011964:Receptors, Gastrointestinal Hormone / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000494:pharmacology; D011994:Recombinant Proteins / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D015220:Calcium Channels; D007295:Inositol Phosphates; D015221:Potassium Channels; D044088:Receptors, Galanin; D011964:Receptors, Gastrointestinal Hormone; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D019004:Galanin; D000242:Cyclic AMP; D019204:GTP-Binding Proteins