[A study on the level of antibody against measles through maternal-fetal transfer and the immuno-response to measles vaccine among 4 to 7 month olds].
A total number of 143 infants at the age of 4 to 7 months from Yantai city-Shandong was selected for the study of antibody level against measles by maternal-fetal transfer and immuno-response to measles vaccine in October of 1993. The results showed that the negative rates of maternal-fetal antibody among infants of 4, 5, 6 and 7 month olds were 75.00%, 81.25%, 94.87% and 90.1%, respectively. The positive rates and geometric mean titers (GMTs) for immuno-response to measles vaccine were 92.86%, 84.38%, 97.44%, 100.00% and 55.17, 42.41, 69.95, 71.46, respectively. There were significant lower immune response to measles vaccine in infants who had high titer ( > 1:2) than those who had low titer ( <or= 1:2) of maternal-fetal antibody (chi 2 = 88.38, P < 0.001). In order to decrease the number of measles cases under 1 year old (especially under 9 month-old), the author suggested that the primary immunization for measles vaccine should be started at 6 month olds.
Liu
B Y
BY
Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan.
Feng
Z X
ZX
Xu
A Q
AQ
D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination / Q000379:methods
D000914:Antibodies, Viral; D008458:Measles Vaccine