Populations of thymocytes and peripheral blood leucocytes in leukaemia-bearing mice treated with G-CSF.
The influence of granulocyle-colony stimulating factor (G-CSF) on thymocyte subsets and peripheral blood leucocytes in leukaemia L1210-bearing mice was evaluated. Leukaemia-bearing mice have a markedly reduced L3T4+Lyt2+ thymocyte subpopulation. We observed "correction" of relative values of thymocyte subpopulations induced by treatment of mice with a G-CSF preparation. The suggestion is presented that this could result from liberation of lymphocyte T precursor cells from the bone marrow and increased homing of them into the thymus. The direct or indirect influence of G-CSF on the L3T4+Lyt2+ subpopulation of thymocytes is discussed.
Kawiak
J
J
Department of Clinical Cytology, Medical Center of Postgraduate Education, Warsaw Poland.
Hoser
G
G
Miks
B
B
Pojda
Z
Z
Sobiczewska
A
A
Machaj
E
E
Wrembel
A
A
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D000950:Antigens, Ly / Q000276:immunology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000276:immunology* / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D016179:Granulocyte Colony-Stimulating Factor