Effect of growth hormone administration on serum somatomedin-C levels in bilharzial and liver disorders patients.
This work was designed in an attempt to clarify the effect of growth hormone injection on the serum somatomedin-C (SM-C) levels in Egyptian children with (1) urinary bilharziasis, (2) advanced bilharzial hepatic fibrosis, and (3) children suffering from chronic hepatitis, in comparing with 11 healthy age- and sex-matched children,, served as controls. SM-C levels were studied prior and after injection of human growth hormone (hGH). The basal and hGH-stimulated SM-C levels were significantly reduced in bilharzial patients compared with controls. Patients with hepatitis had significantly lower serum SM-C values prior or post hGH administration. Liver tests carried out for bilharzial patients showed impaired function both on admission and after treatment. It can concluded from this work that shortness in children with bilharzial hepatic fibrosis may be result of hepatic and endocrinal factors and nutritional. Also, our results suggested that the delayed skeletal maturation in chronic hepatitis cases is probably secondary to liver dysfunction, malnutrition and associated endocrinopathies.
Ahmed
S A
SA
Department of Medicinal Chemistry, National Research Center, Dokki, Cairo, Egypt.
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001827:Body Height; D002648:Child; D005260:Female; D013006:Growth Hormone; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood* / Q000469:parasitology*; D008111:Liver Function Tests; D008297:Male; D012016:Reference Values; D012552:Schistosomiasis / Q000097:blood* / Q000652:urine
D015415:Biomarkers; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone