[Detection of micrometastases in the bone marrow in patients with gastric cancer].
An immunocytochemical method using an antibody probe to recognise the epithelial membrane antigen was used to screen smears obtained surgically from bone-marrow in 88 patients with gastric cancer. Tumor cells were detected in the bone-marrow of 58 patients (65.9%). The EMA positive cells in the marrow were not correlated with the location and node status of the stomach. In the stage of TNM I, II, III and IV, the positive rates of micrometastases in the bone marrow were 42.9%, 57.1%, 73.7% and 69.0%, respectively. The results showed that the poorer differentiated lesion, the higher rate of positive cells in the bone marrow. The curative surgery and multimodality treatment after operation could result in remission of positive cells in some patients. The method can detect occult metastases in bone marrow, and may be useful to monitor patients for evidence of response. It can measure the efficacy of adjuvant therapy, and predict prognosis of the patients.
Liu
F
F
Nanjing General Hospital, Nanjing Unit of People's Liberation Army.
Li
J
J
Zhang
J
J
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary*; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000556:secondary; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000556:secondary*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D018396:Mucin-1