title: Improvement of peripheral blood lymphocyte subsets in primary biliary cirrhosis after ursodeoxycholic acid therapy.
abstract: Immunological abnormalities frequently observed in patients with primary biliary cirrhosis are considered to be related to the pathogenesis of this disease. We performed a prospective trial to evaluate whether immune mechanisms play a role in the effectiveness of ursodeoxycholic acid (UDCA) therapy. Fifteen female patients with primary biliary cirrhosis were followed for 1 year and were then treated with UDCA (600 mg/day) for another year. Laboratory tests, including peripheral blood lymphocyte subsets assessed by dual colour fluorescence analysis using monoclonal antibodies against respective T cell markers, were evaluated at the beginning of the study, at the start of therapy and at the end of therapy. In primary biliary cirrhosis, the proportion of cytotoxic T cells, suppressor inducer T cells and alpha beta-receptor bearing T cells were significantly lower than in healthy controls. No significant changes were observed in the proportions during the year before the therapy. These reductions, however, recovered to normal ranges after 1 year of UDCA therapy. These changes were associated with an improvement in the serum levels of aspartate aminotransferase, alkaline phosphatase, gamma-globulin and IgM. The close correlation between the improvement in the imbalance of lymphocyte subsets after the therapy and the clinical status suggests that an immunological process may play a role in the effectiveness of therapy in primary biliary cirrhosis.
authors.affiliation: Department of Internal Medicine, Yokosuka Kyousai Hospital, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: C
authors.initials: C
authors.lastname: Sato
authors.forename: O
authors.initials: O
authors.lastname: Noguchi
authors.forename: F
authors.initials: F
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Tozuka
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000368:Aged; D001773:Blood Cells / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood* / Q000188:drug therapy*; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D014580:Ursodeoxycholic Acid