Malignant chondroid syringoma: immunohistopathology.
Malignant chondroid syringoma, also called malignant mixed tumor of the skin, is a rare variant of a malignant tumor derived from sweat gland cells. Histologically the tumor is composed of an epithelial and a mesenchymal component. The epithelial structures show glandular differentiation and carcinomatous features. They are embedded in a mucinous stroma with spindle mesenchymal cells and areas of chondroid differentiation. The epithelial cells express cytokeratins. The luminal epithelial cells show binding to the lectin Ulex europaeus; intraluminal cells are carcinoembryonic antigen positive. The stromal cells are cytokeratin negative and sporadically positive for vimentin. Chondroid areas are S-100 protein and vimentin positive. No labeling for actin is seen.
Metzler
G
G
Department of Dermatology, University of Tubingen, Germany.
Schaumburg-Lever
G
G
Hornstein
O
O
Rassner
G
G
D008949:Adenoma, Pleomorphic / Q000737:chemistry* / Q000473:pathology*; D000328:Adult; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013544:Sweat Gland Neoplasms / Q000737:chemistry* / Q000473:pathology*