title: Cell cycle control of eukaryotic DNA replication.
abstract: A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G1 and preventing re-replication in G2. A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G1 or G2 state, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.
authors.affiliation: Department of Zoology, University of Oxford, UK. kearsey@vax.ox.ac.uk
authors.forename: S E
authors.initials: SE
authors.lastname: Kearsey
authors.forename: K
authors.initials: K
authors.lastname: Labib
authors.forename: D
authors.initials: D
authors.lastname: Maiorano
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D004261:DNA Replication / Q000502:physiology*; D015003:Yeasts / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins