The angiotensin-I converting enzyme (ACE) gene I/D polymorphism and ACE levels in Pima Indians.
An insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with plasma ACE levels in white populations. The occurrence of the I/D polymorphism and relationship to ACE levels was examined in a Pima Indian group (n = 305). The frequency of the D allele was lower in Pimas than whites (0.29 v 0.52 respectively). ACE levels were significantly associated with genotype in both groups (p = 0.0001), which accounted for 6.5% of the variation in ACE levels in Pimas and 18% in whites. The association of the I/D polymorphism with ACE levels confirms the relationship across ethnic groups. The low frequency of the D allele in Pima Indians shows that ethnic differences should be accounted for when studying the ACE gene.
Foy
C A
CA
Department of Clinical Medicine, University of Leeds, UK.
McCormack
L J
LJ
Knowler
W C
WC
Barrett
J H
JH
Catto
A
A
Grant
P J
PJ
D000328:Adult; D000368:Aged; D001130:Arizona; D004251:DNA Transposable Elements / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006720:Homozygote; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A