Association of responsiveness to the major pollen allergen of Parietaria officinalis with HLA-DRB1* alleles: a multicenter study.
Parietaria, a plant belonging to the family of Urticaceae, is a major source of allergenic pollen in Europe. In the context of a multinational study, we investigated whether in allergic subjects antibody response towards Par o 1, the major allergen from P. officinalis, was associated with defined HLA-DRB1* alleles. The study population consisted of 234 allergic patients: 65 from Bulgaria, 30 from Israel, 99 from Italy, and 40 from Spain. In the Italian study group, the prevalence of ST positivity to Parietaria was 77%. In Parietaria ST-positive subjects, the prevalences of IgG and IgE serum Ab towards Par o 1 were 91% and 75%, respectively. HLA-DRB1*1101 and/or 1104 were significantly positively associated with the presence of IgG Ab and with high levels of IgE Ab towards this allergen (p = 0.0007 and p = 0.012, respectively). In the Spanish study group, the positive association of DR1100 with responsiveness to Par o 1 was confirmed (p = 0.02, RR = 4, and p = 0.002, RR = 7, for IgG and IgE Ab, respectively). None of the Bulgarian patients had IgE Ab to Par o 1, whereas IgG Ab response was observed in 7 out of 65 subjects and was positively associated with DRB1*1101 and/or 1104 (p = 0.025). In the Israeli study group, responsiveness to Par o 1 was not associated with specific HLA-DRB1* alleles. In conclusion, this study shows that in allergic patients from three European populations antibody response to the major allergen from the pollen of Parietaria is associated with HLA-DRB1*1101 and/or 1104. Our data suggest that this association is stronger in subjects monosensitized to Parietaria.
D'Amato
M
M
Institute of Cellular Biology, CNR, Rome, Italy.
Scotto d'Abusco
A
A
Maggi
E
E
Menna
T
T
Sacerdoti
G
G
Maurizio
S M
SM
Iozzino
S
S
De Santo
C
C
Oreste
U
U
Tosi
R
R
D'Amato
G
G
Baltadijeva
D
D
Bjorkstén
B
B
Freidhoff
L R
LR
Lahoz
C
C
Marsh
D G
DG
Rashef
A
A
Ruffilli
A
A
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000485:Allergens / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology*; D059811:HLA-DRB1 Chains; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007428:Intradermal Tests; D008875:Middle Aged; D010940:Plant Proteins; D011058:Pollen / Q000276:immunology*
D000485:Allergens; D006023:Glycoproteins; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D007074:Immunoglobulin G; C072038:Par o I protein, Parietaria officinalis; D010940:Plant Proteins; D007073:Immunoglobulin E