title: Changes in spontaneous unit activity in lumbar spinal cord after reversible aortic occlusion in the rat.
abstract: Lumbar dorsal horn neuronal multiunit activity was recorded in the halothane anesthetized rat before, during, and after a 30 min interval of spinal cord ischemia induced by inflation of a balloon catheter inserted through the femoral artery. After initiation of ischemia, there was typically a brief burst of neuronal activity, followed by electrical silence. During reperfusion, there was a progressive increase in discharge activity over the ensuing 30 min. Spontaneous activity was significantly increased, as measured by the number of discriminable cells and frequency of discharges. Post-ischemic hyperactivity reached maximal values typically after 60-90 min of reperfusion. The character and time course of recorded activity are consistent with the behavioral sequelae of transient spinal ischemia.
authors.affiliation: Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Galik
authors.forename: M
authors.initials: M
authors.lastname: Marsala
authors.forename: T L
authors.initials: TL
authors.lastname: Yaksh
mesh_terms: D000818:Animals; D004594:Electrophysiology; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000503:physiopathology*; D013116:Spinal Cord / Q000098:blood supply* / Q000503:physiopathology