zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains.
A cDNA encoding the complete reading frame of a novel homeodomain-containing protein, named zhx-1, has been cloned from a mouse bone marrow stromal cell line. The ORF encodes a protein of 873 amino acids, in which two C2-H2 zinc-fingers and five homeodomains have been identified. These features classify zhx-1 as a member of the ZF class of homeodomain transcription factors, zhx-1 mRNA is widely expressed in adult mouse, although it is preferentially expressed in brain. At least, two homologous mRNAs are present in humans suggesting that zhx-1 is the first member of a novel subclass of homeodomain factors.
Barthelemy
I
I
Departamento de Investigación, Pharmacia & Upjohn, Madrid, Spain.
Carramolino
L
L
Gutiérrez
J
J
Barbero
J L
JL
Márquez
G
G
Zaballos
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D018076:DNA, Complementary; D018398:Homeodomain Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012333:RNA, Messenger / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers
D018076:DNA, Complementary; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C100746:Zhx1 protein, mouse