Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng.
A genuine glycoside, named ginsenoside Rh4, was isolated from Korean red ginseng (Panax ginseng C. A. Meyer) through repeated column chromatography, and its chemical structure was established to be 6-O-beta-D-glucopyranosyldammar-20(22),24-diene-3 beta,6 alpha,12 beta-triol by spectral and chemical methods. The stereochemistry of a double bond at C-20(22) of ginsenoside Rh4 was characterized as (E) from a NOESY experiment in the 1H-NMR of the aglycone. Cytotoxic activities of ginsenoside Rh4 and its aglycone against cancer cell lines were evaluated by use of the SRB method.
Baek
N I
NI
Korea Ginseng & Tobacco Research Institute, Taejeon, Korea.
Kim
D S
DS
Lee
Y H
YH
Park
J D
JD
Lee
C B
CB
Kim
S I
SI
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002240:Carbohydrate Sequence; D036145:Ginsenosides; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; D012503:Saponins; C101280:ginsenoside Rh4