title: Bone marrow transplantation from unrelated donors.
abstract: Unrelated donor bone marrow transplants provide the alternative to allogeneic transplants for patients lacking an HLA-matched related family member donor. Because the donor and recipient have greater immunogenetic disparity than related donor transplants, these transplants are associated with a higher rate of immunologic complications. This disparity has also translated into a lower risk of relapse relative to sibling donor transplants, enabling this treatment to offer a cure to advanced-disease patients.
authors.affiliation: University of Texas M.D. Anderson Cancer Center, Section of Bone Marrow Transplantation, Houston 77030, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gajewski
authors.forename: R
authors.initials: R
authors.lastname: Champlin
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens