title: [The immunotropic properties of biologically active products obtained from Klamath weed (Hypericum perforatum L.)].
abstract: We carried out a systematic study of immunotropic activity of John's wort on the level of integrated fractions including all basic active substances of this plant. Both types of substances capable of increasing and suppressing the immunity were found in John's wort. Polyphenol fraction exhibits the immunostimulating activity with respect to the system of mononuclear phagocyte system, cellular and humoral immunity, and is capable of recovering the immune response in conditions of high-zone tolerance. Lipophilic fraction of this plant exhibits immunosuppressing properties with respect to cellular and humoral immune response. Immunotropic activity of polyphenol and lipophilic fractions correlate with their low toxicity.
authors.forename: T A
authors.initials: TA
authors.lastname: Evstifeeva
authors.forename: S V
authors.initials: SV
authors.lastname: Sibiriak
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D010936:Plant Extracts
vernacular_title: Immunotropnye svoĭstva biologicheski aktivnykh produktov, poluchennykh iz zveroboia prodyriavlennogo.