Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians.
We studied the role of lipids in the pathogenesis of noninsulin-dependent diabetes mellitus (NIDDM) in Pima Indians. High plasma levels of nonesterified fatty acid (NEFA) predicted development of NIDDM, but this effect cannot entirely be explained by the glucose-fatty acid cycle. Dyslipidemia, although often associated with diabetes, did not seem to predict NIDDM and might rather be associated with, or the consequence of insulin resistance. In some individuals, a single amino acid substitution in the intestinal fatty acid binding protein could result in increased rates of intestinal absorption of dietary NEFA and thereby contribute to increased lipid-oxidation rates and insulin resistance.
Tataranni
P A
PA
National Institutes of Health, National Institute of Diabetes and Digestive Kidney Diseases, Clinical Diabetes and Nutrition Section, Phoenix, Arizona 85016, USA.
Baier
L J
LJ
Paolisso
G
G
Howard
B V
BV
Ravussin
E
E
D001130:Arizona; D002352:Carrier Proteins / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000503:physiopathology*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006801:Humans; D007198:Indians, North American; D007333:Insulin Resistance; D007413:Intestinal Mucosa / Q000378:metabolism; D008055:Lipids / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D018996:Myelin P2 Protein / Q000032:analysis; D009363:Neoplasm Proteins; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D012307:Risk Factors; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins