[A method for assessing the analgesic action of drug preparations].
A method for objective evaluation of analgetic activity of drugs is proposed. The method consists in measuring changes in skin galvanic potential response to swallowing prior to and after administration of the drug to the patients within 2-3 days after tonsillectomy. The pain in the throat is of swallowing-induced character and thus results in orientation response which can be detected via changes in skin potential. The more the intensity of the pain the greater the response. The method is used in studying the analgetic effect of benzofurocain.
Gorbonosov
I V
IV
Semenov
F V
FV
D000779:Anesthetics, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001572:Benzofurans; D003679:Deglutition / Q000187:drug effects; D004177:Dipyrone / Q000627:therapeutic use; D004341:Drug Evaluation / Q000379:methods; D005712:Galvanic Skin Response / Q000187:drug effects; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy* / Q000503:physiopathology; D011182:Postoperative Care; D013997:Time Factors; D014068:Tonsillectomy
D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; D004177:Dipyrone; C040205:benzofurocaine
Sposob otsenki obezbolivaiushchego deĭstviia lekarstvennykh preparatov.