title: Acute cardiotoxicity of moniliformin in broiler chickens as measured by electrocardiography.
abstract: Electrocardiography was used to examine the acute cardiotoxic effects of moniliformin on 3-week-old broiler chickens. Each of the seven pairs of anesthetized birds (pentobarbital sodium, 40 mg/kg body weight, intramuscular) was injected intravenously with moniliformin (1 mg/kg body weight) or an equal volume of normal saline (1 ml/kg body weight), and changes in electrocardiogram were monitored for 50 minutes. Three of the seven birds injected with moniliformin died within 50 minutes post-injection. Moniliformin caused a bradycardia, which became highly significant (P < 0.05) within 15 minutes post-injection. The P-R, Q-T, and S-T intervals of moniliformin-injected birds were significantly lengthened throughout the 50-minute observation (P < 0.05). The results indicate that the moniliformin-induced mortality is due primarily to cardiac failure.
authors.affiliation: Department of Poultry Science, University of Wisconsin, Madison 53706, USA.
authors.forename: R Y
authors.initials: RY
authors.lastname: Nagaraj
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: J A
authors.initials: JA
authors.lastname: Will
authors.forename: R F
authors.initials: RF
authors.lastname: Vesonder
mesh_terms: D000818:Animals; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D002645:Chickens; D003503:Cyclobutanes / Q000008:administration & dosage / Q000633:toxicity*; D004562:Electrocardiography / Q000662:veterinary; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D009183:Mycotoxins / Q000008:administration & dosage / Q000633:toxicity*; D011201:Poultry Diseases / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D003503:Cyclobutanes; D009183:Mycotoxins; C008539:moniliformin