Regulatory mechanisms of antitumor T cell responses in the tumor-bearing state.
Tumor-bearing hosts develop antitumor immune responses. However, a number of immunosuppressive mechanisms come into operation with the progression of tumor growth. This article will review the observations regarding the modulation of antitumor immune responses in the tumor-bearing state, and consider the mechanisms underlying tumor-induced immune defects, especially in the light of the induction of an abnormal cytokine network. We will also describe the restoration of suppressed antitumor immune responses by administration of a particular cytokine, interleukin-12.
Fujiwara
H
H
Biomedical Research Center, Osaka University Medical School, Japan.
Hamaoka
T
T
D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology; D005354:Fibrosarcoma / Q000276:immunology*; D007108:Immune Tolerance; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology / Q000627:therapeutic use; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000276:immunology; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D016207:Cytokines; D007376:Interleukin-2; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D007371:Interferon-gamma