Neural cell adhesion molecule (N-CAM) as a marker of muscle tissue alternations. Review of the literature and own observations.
In this paper the expression of neural cell adhesion molecule (N-CAM) analyzed by indirect immunofluorescence on human skeletal muscle is reported. In adult human muscle N-CAM is concentrated near neuromuscular junctions and on satellite cells but is nearly undetectable in non synaptic portions of myofibers. N-CAM is abundant on myotubes and intramuscular nerves in embryonic muscle but is lost as development proceeds. After denervation N-CAM appears along the entire length of muscle fibers. In addition N-CAM is observed on the surface of regenerating muscle cells. These data suggest that N-CAM immunohistochemistry may play complement conventional technique in the diagnosis of neuromuscular diseases.
Fidziańska
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Department of Neurology, School of Medicine, Polish Academy of Sciences, Warszawa.
Kamińska
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D000328:Adult; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000196:embryology / Q000503:physiopathology / Q000648:ultrastructure*; D009136:Muscular Dystrophies / Q000503:physiopathology; D019006:Neural Cell Adhesion Molecules / Q000502:physiology*
D019006:Neural Cell Adhesion Molecules