title: [Comparative human pharmacokinetic studies of 20 mg nifedipine-containing Cordaflex and Adalat film coated retared tablets].
abstract: Comparative pharmacokinetic studies have been carried out with two 20 mg nifedipine active substance-containing retard film coated tablets, Cordaflex produced by EGIS Pharmaceuticals Co., Ltd. and Adalat of Bayer AG. The pharmacokinetic parameters and the relative bioavailability were determined in 15 and 16 healthy male volunteers, respectively after single and repeated administration in open, randomized cross over study. The plasma concentration of nifedipine was determined by HPLC-ED method, using laboratory robot for automated sample preparation. On the basis of graphical and statistical comparison of the pharmacokinetic parameters (AUC0-infinity, AUCss,0-tau, tmax, Cmax, Css,min, Css,av, MRT, etc.) calculated from the time-plasma concentration curve, moreover on the basis of clinical results, there was no significant difference between the two preparations. In conclusion, the relative bioavailability of Cordaflex and Adalat 20 mg retard tablets did not show significant difference after single and repeated administration.
authors.forename: I
authors.initials: I
authors.lastname: Klebovich
authors.forename: G
authors.initials: G
authors.lastname: Horvai
authors.forename: G
authors.initials: G
authors.lastname: Grézal
authors.forename: N K
authors.initials: NK
authors.lastname: Baloghné
authors.forename: V
authors.initials: V
authors.lastname: Horváth
authors.forename: E
authors.initials: E
authors.lastname: Kocsi
authors.forename: J
authors.initials: J
authors.lastname: Balogh
authors.forename: A
authors.initials: A
authors.lastname: Cseh
authors.forename: C
authors.initials: C
authors.lastname: Farsang
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D009543:Nifedipine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets; D013810:Therapeutic Equivalency
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D009543:Nifedipine
vernacular_title: Cordaflex és Adalat 20 mg filmtabletták összehasonlító humán farmakokinetikája egyszeri és ismételt dozírozás után.