[The clinical significance of selenium deficiency in patients from the Samara region with cardiovascular diseases and its correction with the preparation Selena].
Selenium concentration in blood, glutathionperoxidase (GSH-Px) activity in erythrocytes and lipid peroxides in plasma were studied in patients with ischemic heart disease, hypertrophic (HCMP) and dilated cardiomyopathy (DCMP). Patients with IHD, HCMP and DCMP revealed depressed activity of GSH-Px with activation of lipid peroxides associated with lowered selenium content in blood. The selenium content in blood was lower in patients with severe forms of IHD Daily intake of 300 micrograms selenium with "Selena" during a month increases selenium concentration by 71% in patients with IHD and DCMP. This increase change inversely with primary selenium concentration in plasma. Plasma Malone dialdehyde concentration decreased by 17%. The results obtained suggest participation of selenium in cardiomyopathy and IHD pathogenesis, thus forming a basis for selecting the patients with selenium deficiency for its further correction with "Selena."
Kuznetsov
G P
GP
Lebedev
P A
PA
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012426:Russia; D012643:Selenium / Q000097:blood / Q000172:deficiency*; D012645:Selenomethionine / Q000627:therapeutic use*; D013607:Tablets
D000975:Antioxidants; D013607:Tablets; D008315:Malondialdehyde; D012645:Selenomethionine; D012643:Selenium
Klinicheskoe znachenie selenodefitsita u bol'nykh s serdechno-sosudistymi zabolevaniiami Samarskogo regiona i ego korrektsiia preparatom "Selena".