[Construction and radioimmunodetection of nude mouse xenograft of human choriocarcinoma].
Fresh tissue of human choriocarcinoma was injected subcutaneously into the BALB/C nude mouse. The xenografts had grown up with 16-68 passages. The hCG level of the ascites or intratumoral blood was 400-20,000 mIU/ml. Radioimmunodetection was performed using 131I labelled murine anti-hCG McAb. The labelled antibody could be specifically accumulated in the tumor sites and the tumor imaging was acquired. The ideal imaging time was 72-96 hours after the injection of antibody.
Zhang
D
D
PUMC Hospital, CAMS, Beijing.
Yang
X
X
Zhang
H
H
Liu
X
X
Li
F
F
D000818:Animals; D002822:Choriocarcinoma / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011247:Pregnancy; D016719:Radioimmunodetection; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes