title: Lipoprotein(a) and general risk factors in patients with angiographically assessed peripheral arterial disease.
abstract: High lipoprotein(a) [Lp(a)] has been observed in patients with ischemic heart disease and cerebrovascular disease. Lp(a) is actually thought to be an independent risk factor for coronary disease. We therefore carried out a case-control study, evaluating plasma Lp(a) in 61 patients with angiographically documented peripheral arterial disease (PAD) and in 61 age- and sex-matched patients with no cardiovascular disease. General risk factors for vascular disease were also taken into account. Lp(a) was significantly higher in patients than controls (257.0 +/- 34.8 vs 146.5 +/- 23.5 mg/l p < 0.05), as were cigarette smoking, diabetes, cholesterolemia, fibrinogenemia and the waist-to-hip circumference ratio. Stepwise logistic regression analysis showed that, in addition to cigarette smoking, diabetes, cholesterol and fibrinogen, Lp(a) is a significant independent risk indicator for PAD. This result suggests that high plasma Lp(a) is associated with enhanced risk of PAD and must therefore be evaluated alongside traditional risk factors.
authors.affiliation: Divisione di Riabilitazione e Prevenzione per la Patologia Vascolare, Università di Verona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Prior
authors.forename: E
authors.initials: E
authors.lastname: Arosio
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: L
authors.initials: L
authors.lastname: Lucchese
authors.forename: G C
authors.initials: GC
authors.lastname: Guidi
authors.forename: O
authors.initials: O
authors.lastname: Bosello
mesh_terms: D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000000981:diagnostic imaging* / Q000209:etiology; D001824:Body Constitution; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000000981:diagnostic imaging* / Q000209:etiology; D011446:Prospective Studies; D011859:Radiography; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D017270:Lipoprotein(a); D005340:Fibrinogen; D002784:Cholesterol