[The action of adrenergic agonists and antagonists on kidney function and arterial pressure depending on the mineral component of the diet].
The experiments on rats showed that high consumption of sodium chloride promotes the diuretic action of phenylephrine (mesaton), the alpha-adrenergic agonist, and prolong its pressor effect. In supplementation of diet with sanasol and hyposol, a new substitute of common salt, phenylephrine, causes the renal effects typical of beta-adrenoceptor stimulation. Both the sanasol and especially hyposol decrease the strength and duration of phenylephrine pressor action and increase the duration of isadrine depressor effect. Thus, the reactivity of alpha- and beta-adrenergic mechanisms depend on the mineral composition of diet, which is able to change the pharmacodynamics of cardiovascular agents.
Shtrygol'
S Iu
SIu
Branchevskiĭ
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D000322:Adrenergic Agonists / Q000494:pharmacology*; D018674:Adrenergic Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D017673:Sodium Chloride, Dietary
Deĭstvie adrenergicheskikh agonistov i antagonistov na funktsiiu pochek i arterial'noe davlenie v zavisimosti ot mineral'nogo sostava ratsiona.