title: Vertebral bone destruction in sickle cell disease: infection, infarction or both.
abstract: Infectious and vaso-occlusive vertebral bone and joint destruction in two patients with sickle cell disease (SCD) are featured by H-shaped vertebrae, kyphotic angulation, osteolysis of endplates and collapse of intervertebral discs as shown by X-ray films and magnetic resonance imaging. Staphylococcal serology supported the diagnosis of staphylococcal osteomyelitis/spondylo-discitis in both SCD patients. The difficulties of establishing the causes and treatment of the osteoarthropathy in these particular cases are discussed in the light of the literature.
authors.affiliation: Department of Internal Medicine III, University Hospital Rotterdam, Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Kooy
authors.forename: L J
authors.initials: LJ
authors.lastname: de Heide
authors.forename: A J
authors.initials: AJ
authors.lastname: ten Tije
authors.forename: A H
authors.initials: AH
authors.lastname: Mulder
authors.forename: H L
authors.initials: HL
authors.lastname: Tanghe
authors.forename: J A
authors.initials: JA
authors.lastname: Kluytmans
authors.forename: J J
authors.initials: JJ
authors.lastname: Michiels
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D015299:Discitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D010019:Osteomyelitis / Q000150:complications* / Q000175:diagnosis; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013904:Thoracic Vertebrae; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents