[The effect of the subchronic administration of calcium-channel blockers on CNS excitability].
The effect of a single day administration of nifedipine (10 mg/kg), cinnarizine (25 mg/kg), verapamile (25 mg/kg), fendiline (10 mg/kg), dilthiazem (10 mg/kg), and diazepam (0.5 mg/kg) on the dynamics of changing a convulsive dose of convulsant was studied on a model of intermittent intracutaneous administration of Corazole (10 mg/kg until convulsions) during 5 days. Repeated intermittent Corazole administrations were found to increase the sensitivity of animals with respect to convulsive effect of the drug. All calcium channel blockers and diazepam increased the convulsive dose of Corazole. In accordance with the hypothesis of anxiety disturbances based on nonspecific CNS activation, a possibility of application of calcium channel blockers as potential anxiolytics is considered.
Kozlovskiĭ
V L
VL
Mosin
A E
AE
Ivakina
L V
LV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D003292:Convulsants / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007279:Injections, Subcutaneous; D008297:Male; D010433:Pentylenetetrazole / Q000008:administration & dosage; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013997:Time Factors
D014151:Anti-Anxiety Agents; D002121:Calcium Channel Blockers; D003292:Convulsants; D010433:Pentylenetetrazole
Vliianie subkhronicheskogo vvedeniia blokatorov kal'tsievykh kanalov na vozbudimost' TsNS.