Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis.
The serum IL-1 beta, IL-2, IL-4, IL-6, IL-8, TNF-alpha and soluble IL-2 receptor levels were measured, and the presence of anti-Fc gamma receptor (Fc gamma R) antibodies was investigated in the sera of 18 patients with systemic sclerosis (SSc). An increase of TNF-alpha was detected in 8 of the 18 cases. II-1 beta was elevated in all the 18 patients. Both IL-2 and IL-4 were elevated in 7 cases. The IL-6 level was elevated in 17 patients, while IL-8 was increased in all cases. The soluble IL-2 receptor level was elevated in 11 patients. Fc gamma R-specific antibodies were detected in the sera of 6 patients, and there was a significant association between anti-Fc gamma R antibody positivity and IL-4 elevation. The presence of anti-Fc gamma R antibodies may influence several cell functions and may contribute to the remarkable variability of cytokine levels in SSc.
Szegedi
A
A
Department of Dermatology, University Medical School of Debrecen, Hungary.
Czirják
L
L
Unkeless
J C
JC
Boros
P
P
D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007378:Interleukins / Q000097:blood; D008875:Middle Aged; D017452:Receptors, IgG / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000097:blood* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D016207:Cytokines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007378:Interleukins; D017452:Receptors, IgG; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha