[Neuroprotection in cerebral ischemia].
It have been reviewed the different mechanisms involved in the development of cerebral ischemia and infarct, as well as the possible interaction and potentiation among them. Experimental and clinical trials undertaken with different drugs, such as glutamate antagonists, calcium channel blockers and free radical antagonists are discussed on the light of their possible application in prophylactic neuroprotection.
Martínez-Vila
E
E
Departamento de Neurología y Neurocirugía, Clínica Universitaria de la Facultad de Medicina, Universidad de Navarra, Pamplona.
Vázquez Espiérrez
C
C
D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005609:Free Radicals / Q000378:metabolism; D005732:Gangliosides / Q000627:therapeutic use*; D006801:Humans
D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D005609:Free Radicals; D005732:Gangliosides
Neuroprotección en isquemia cerebral.