BCR/ABL and leukemia.
This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of possible therapeutic implications of these data.
Butturini
A
A
Department of Pediatrics, University of Parma, Italy.
Arlinghaus
R B
RB
Gale
R P
RP
D000818:Animals; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*
D016044:Fusion Proteins, bcr-abl