[Study on essence of liver-qi stagnation in ulcerative colitis].
The links between stagnation of the Liver-Qi in the pathogenesis and ulcerative colitis (UC) were clinically and experimentally studied using the principle of nourishing the Liver in treated group and the principle of invigorating the Spleen in control group. The results showed that the effective rate was 96% in treated group and 82% in control group, and the difference was significant (P < 0.05); the formation rate of E rosettes and the transformation rate of lymphocytes were significantly raised in the two groups compared with the pre-treatment period, treated group was evidently superior to control group in the rate of dysfunction of autonomous nerve system (P < 0.01). The level of intestinal styrenated phenol (SP) and vasoactive intestinal polypeptide (VIP) of UC model were determined in rats. The results showed that the level of SP and VIP significantly increased in UC model group. They markedly lowered in treated group compared with model group (P < 0.01) and there was significant difference in comparing with control group (P < 0.01). It revealed that Wei Chang Ning, a drug to nourishing the Liver, had the action of regulating neurological -endocrinological (gastrointestinal hormone)-immunological system.
Yan
Q M
QM
Dept. of TCM, Chengdu Military Regional General Hospital.
Chen
Y
Y
Lian
N
N
D000328:Adult; D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation; D013373:Substance P / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005765:Gastrointestinal Agents; D013373:Substance P; D014660:Vasoactive Intestinal Peptide