The delivery of insulin from aqueous and non-aqueous reservoirs governed by a glucose sensitive gel membrane.
A self regulating delivery device, responsive to glucose, has been shown to operate successfully in vitro. This comprises a gel membrane which determines the delivery rate of insulin from a reservoir. The gel consists of a synthetic polysucrose and the lectin, concanavalin A. The mechanism is one of displacement of the branched polysaccharide from the lectin receptors by incoming glucose. The gel loses its high viscosity as a result but reforms on removal of glucose, thus providing the switch controlling the drug diffusion rate. The drug does not require to be chemically modified and thus the device is adaptable to other anti-hyperglycaemic drugs. However, results here indicate that the molecular weight of the solute may be an important parameter. Others include path length, gel formulation and temperature. It had been hypothesised that the reversal might be improved by the use of a non-aqueous reservoir of insulin. However, with the use of insulin, the switching off was found to be superior to that found with other test solutes used in previous studies, irrespective of the reservoir solvent. The advantages in the use of the non-aqueous system include, however, more reproducibility in the magnitude of response and a reduced temperature sensitivity.
Taylor
M J
MJ
Department of Pharmaceutical Sciences, De Montfort University, Leicester, UK.
Tanna
S
S
Taylor
P M
PM
Adams
G
G
D003208:Concanavalin A / Q000737:chemistry; D005782:Gels; D005947:Glucose / Q000737:chemistry; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D011134:Polysaccharides / Q000737:chemistry; D013696:Temperature
D005782:Gels; D007328:Insulin; D011134:Polysaccharides; D003208:Concanavalin A; D005947:Glucose