Changes of morphological, biological and antigenic properties of avian influenza A virus haemagglutinin H2 in the course of adaptation to new host.
The alterations of avian influenza A virus haemagglutinin (HA) H2 as a result of adaptation to mice were first investigated in this study. HA of mouse-adapted (MA) variant was somewhat different from that of the original strain in electrophoretical mobility, antigenic structure and in haemagglutination activity with mouse red blood cells.
Lipatov
A S
AS
D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow, Russia.
Gitelman
A K
AK
Govorkova
E A
EA
Smirnov YuA
D000222:Adaptation, Physiological; D000818:Animals; D001717:Birds; D002460:Cell Line; D002642:Chick Embryo; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000276:immunology; D006386:Hemagglutination Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology / Q000821:virology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000821:virology*
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral