[Effect of age on hemostasis and plasma level of TXB2 and 6-keto-PGF1 alpha].
Hemostasis (HS) in 134 healthy subjects of over 20 years old was investigated. The cases with HS symptom were 45.5%, which increased with age. TXB2, 6-keto-PGF1 alpha and T/K ratio were measured by radioimmuno assay (RIA).


RESULTS
elevation of TXB2 was more significant in the middle age and old age than in the young group (P < 0.01). But the level of 6-keto-PGF1 alpha in various age group didn't changed significantly; while the ratio between TXB2 and 6-keto-PGF1 alpha was more significant in the aged than in the young person (P < 0.01). The results revealed that there was hypercoagulable tendency with the increase of age, and it was correlated with TXB2 and 6-keto-PGF1 alpha. It is significant in theory and practice to prevent and cure the cardiovascular and cerebrovascular disease as well as HS with the traditional Chinese medicine.
Liang-min
L D
LD
Union Hospital of Fujian Medical College, Fuzhou.
Lu
L H
LH
Zhang
X M
XM
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D001809:Blood Viscosity; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D013577:Syndrome; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha