A stochastic model for circulatory transport in pharmacokinetics.
A new stochastic model for the residence time distribution of a drug injected instantaneously into the circulatory system is proposed and analyzed. The properties of the residence time are derived from the assumptions made about the cycle time distribution and the rule for elimination. This rule is given by the probability distribution of the number of cycles needed for elimination of a randomly selected molecule of the drug. Only the geometric distribution has been previously used for this purpose. Its transformation is applied here to get a boundary for the residence time. Other discrete distributions are applied with a view to describing different experimental situations. Suitable continuous probability distributions for the cycle time description are discussed.
Lánský
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Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
D001775:Blood Circulation; D006801:Humans; D008433:Mathematics; D008657:Metabolic Clearance Rate; D008955:Models, Cardiovascular; D010599:Pharmacokinetics; D011336:Probability; D013269:Stochastic Processes