title: How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory.
abstract: How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.
authors.affiliation: Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
authors.forename: R H
authors.initials: RH
authors.lastname: Belmaker
authors.forename: Y
authors.initials: Y
authors.lastname: Bersudsky
authors.forename: G
authors.initials: G
authors.lastname: Agam
authors.forename: J
authors.initials: J
authors.lastname: Levine
authors.forename: O
authors.initials: O
authors.lastname: Kofman
mesh_terms: D000818:Animals; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007294:Inositol / Q000008:administration & dosage / Q000378:metabolism*; D008094:Lithium / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats
chemical_list: D018692:Antimanic Agents; D007294:Inositol; D008094:Lithium