title: Myocardial perfusion modeling using MRI.
abstract: In the present study, it is shown that it is possible to quantify myocardial perfusion using magnetic resonance imaging in combination with gadolinium diethylenetriaminopentaacetic acid (Gd-DTPA). Previously, a simple model and method for measuring myocardial perfusion using an inversion recovery turbo-FLASH (fast low-angle shot) sequence and Gd-DTPA has been presented. Here, an extension of the model is presented taking into account fast and slow water exchange between the compartments, enabling the calculation of the unidirectional influx constant (Ki) for Gd-DTPA, the distribution volume of Gd-DTPA (lambda), the vascular blood volume (Vb), and the time delay through the coronary arteries (delta T). The model was evaluated by computer simulation and used on experimental results from seven healthy subjects. The results in the healthy volunteers for a region of interest placed in the anterior myocardial wall were (mean +/- SD) Ki = 54 +/- 10 ml/100 g/min, lambda = 30 +/- 3 ml/100 g, Vb = 9 +/- 2 ml/100 g, delta T = 3.2 +/- 1.1 s. These results are in good agreement with similar results obtained by other methods.
authors.affiliation: Danish Research Center of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: H B
authors.initials: HB
authors.lastname: Larsson
authors.forename: T
authors.initials: T
authors.lastname: Fritz-Hansen
authors.forename: E
authors.initials: E
authors.lastname: Rostrup
authors.forename: L
authors.initials: L
authors.lastname: Søndergaard
authors.forename: P
authors.initials: P
authors.lastname: Ring
authors.forename: O
authors.initials: O
authors.lastname: Henriksen
mesh_terms: D000328:Adult; D003198:Computer Simulation; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA