No association detected between a D3 receptor gene-expressed variant and schizophrenia.
A missense polymorphism (glycine to serine) in the first exon of the dopamine D3 (DRD3) gene was examined in the sib-pairs schizophrenia collection by the transmission test for linkage disequilibrium (TDT). No association due to linkage disequilibrium was detected using TDT. Additionally, no evidence for excess homozygosity was found.
Rothschild
L G
LG
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892-1274, USA.
Badner
J
J
Cravchik
A
A
Gershon
E S
ES
Gejman
P V
PV
D005838:Genotype; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3