[The pharmacokinetics of different drug forms of nifedipine when used singly and in a course as monotherapy and in combination with Cordanum and triampur preparations in patients with arterial hypertension].
Pharmacokinetics of three drugs derived from nifedipine: corinfar, corinfar retard, and SL adalate in the cases of a single and course administration in patients with arterial hypertension and the effect of cordanum and triampur on pharmacokinetics of corinfar retard in combined repeated administration have been studied. The studies were carried out in 6 groups of patients with arterial Hypertension, each group included 10 patients. Nifedipine concentration in blood plasma was determined using a special HPLC procedure within 24 h after administration of the drugs at a dose 20 mg. A pharmacokinetic characteristics of new drug adalate SL with two-step liberation of nifedipine. A possibility of autoinhibition was noted for corinfar and adalate SL in course therapy. A conclusion was made that cordanum and triampur did not affect the pharmacokinetics of corinfar retard.
Kukes
V G
VG
Ignat'ev
V G
VG
Pavlov
S S
SS
Starodubtsev
A K
AK
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid / Q000379:methods; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D009543:Nifedipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011412:Propanolamines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D014223:Triamterene / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D011412:Propanolamines; D006852:Hydrochlorothiazide; C020743:hydrochlorothiazide-triamterene; C011550:talinolol; D009543:Nifedipine; D014223:Triamterene
Izuchenie farmakokinetiki razlichnykh lekarstvennykh form nifedipina pri odnokratnom i kursovom primenenii v monoterapii i v sochetanii s preparatami kordanum i triampur u bol'nykh s arterial'noĭ gipertonieĭ.