title: Synthesis and antimicrobial activity of some 2,5-disubstituted 1,3,4,-thiadiazole derivatives.
abstract: A series of 5-substituted 2-arylamino-1,3,4-thiadiazole derivatives was prepared. The antimicrobial activity of these compounds against some strains of bacteria and a strain of Candida albicans was determined, together with that of the corresponding thiosemicarbazone derivatives, which are intermediates in the synthetical procedure.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Mamolo
authors.forename: L
authors.initials: L
authors.lastname: Vio
authors.forename: E
authors.initials: E
authors.lastname: Banfi
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D013830:Thiadiazoles