Alkalization does not alleviate penile pain induced by intracavernous injection of prostaglandin E1.
OBJECTIVE
A prospective, randomized, double-blind study was done to determine whether alkalization of prostaglandin E1 decreases pain associated with intracavernous injection.


METHODS
Ten subjects with a history of pain following at least 70% of injections of prostaglandin E1 received 2 injections of prostaglandin E1, 1 with and 1 without sodium bicarbonate. Patients reported the duration and intensity of pain following each injection.


RESULTS
Comparing injections of prostaglandin E1 with and without bicarbonate, there were no significant differences in number of subjects reporting pain, or duration and intensity of pain.


CONCLUSIONS
Addition of sodium bicarbonate does not alleviate penile pain associated with injection of prostaglandin E1.
Godschalk
M
M
Division of Geriatric Medicine, Medical College of Virginia, Richmond, USA.
Gheorghiu
D
D
Katz
P G
PG
Mulligan
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000009:adverse effects*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced* / Q000517:prevention & control*; D010413:Penis; D011446:Prospective Studies; D017693:Sodium Bicarbonate / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000009:adverse effects*
D014665:Vasodilator Agents; D017693:Sodium Bicarbonate; D000527:Alprostadil