title: [Polymorphism of placental alkaline phosphatase on the level of DNA and protein in the Mordovian population].
abstract: Data on DNA and enzyme polymorphisms of human placental alkaline phosphatase (PLAP) in Mordvinian populations are presented. Restriction fragment length polymorphism (RFLP) was detected after the digestion of DNA samples with Rsa I and Pst I endounucleases. The frequencies of the second (2) allele for PLAP Pst I and Rsa I were 0.53 and 0.192, respectively. Comparative data suggest that there are no population differences between Mordvinians and Scandinavian ethnic groups. In Mordvinians gene frequencies measured at the level of gene products were PLAP*1(S) = 0.681, PLAP*2(F) = 0.244, PLAP*3(I) = 0.069, and PLAP*18(D) = 0.006, indicating the similarity of the corresponding values in Scandinavians. The observed RFLP and "protein" genotype frequencies were in good agreement with that expected according to the Hardy-Weinberg equation. In the Mordvinian population, as in those, surveyed previously, a strong linkage disequilibrium between Pst I and Rsa I PLAP alleles was observed.
authors.affiliation: Department of Medical Genetics, Umea University, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Bekman
authors.forename: K
authors.initials: K
authors.lastname: Vennberg
authors.forename: L
authors.initials: L
authors.lastname: Bekman
authors.forename: V A
authors.initials: VA
authors.lastname: Spitsyn
authors.forename: A G
authors.initials: AG
authors.lastname: Novoradovskiĭ
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics*; D000483:Alleles; D004247:DNA / Q000032:analysis*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D010641:Phenotype; D010920:Placenta / Q000201:enzymology*; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D012426:Russia
chemical_list: D011257:Pregnancy Proteins; D004247:DNA; D000469:Alkaline Phosphatase
vernacular_title: Polimorfizm shchelochnoĭ platsentarnoĭ fosfatazy na urovne DNK i belka v mordovskoĭ populiatsii.