Acute non-lymphoblastic leukaemia with t(16;21): case report with a review of the literature.
A rare case of acute non-lymphoblastic leukaemia with chromosomal t(16;21)(p11;q22) translocation was studied at the molecular level. Most of the previous reports about the translocation have been described at a karyotypic level. Blast cells of this patient expressed the TLS-ERG chimeric mRNA. The clinical, morphological, karyotypic, and immunohistochemical aspects of this leukaemia are also presented with a review of the literature.
Hiyoshi
M
M
Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Koh
K R
KR
Yamane
T
T
Tatsumi
N
N
D000328:Adult; D001483:Base Sequence; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D014178:Translocation, Genetic