Reproductive and neurobehavioral effects of Sunset yellow FCF administered to mice in the diet.
Selected reproductive and neurobehavioral parameters were measured in mice given the color additive Sunset Yellow FCF in the diet. The additive was given at levels of 0 (control), 0.15, 0.30, and 0.60%, from five weeks of age in the F0 generation to nine weeks of age in the F1 generation. There were few adverse effects on litter size, weight, or sex ratio. Average body weight of offspring during the late lactation period was significantly increased in the low- and middle-dose groups of each sex. In the neurobehavioral parameters, swimming direction was significantly affected in a dose-related manner in male and female offspring during the early lactation period. Also in the early lactation period, surface righting and negative geotaxis were significantly affected in male offspring in the middle-dose group, and swimming head angle was significantly affected in female offspring in a dose-related manner. The dose levels of Sunset Yellow FCF in this study did produce some adverse effects in reproductive and neurobehavioral parameters.
Tanaka
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Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009420:Nervous System / Q000187:drug effects*; D012098:Reproduction / Q000187:drug effects*
D001391:Azo Compounds; C005842:6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt