Human sperm chromosome analysis--study on human sperm chromosome mutagenesis induced by carbon disulfide.
The aim of this study was to investigate the effect CS2 of on human sperm chromosomal aberration. The human sperm/hamster egg fusion technique was used to analyze 203 human sperm chromosome complement from 9 healthy volunteers. The incidence of numerical aberration was 1.0% and that of structural chromosome aberration was 5.9% and total abnormalities was 6.9%. Structural aberrations consisted of breaks, deletions, centric rings, fragments, and chromatid exchange. The results from high concentration group (10 mumol.L-1 CS2) showed that the incidence of chromosomal aberration rate was significantly higher than that of the control group. The results indicate that high concentration of CS2 might directly cause mutagenesis of the germ cell.
Le
J Y
JY
Zhejiang Academy of Medical Sciences, Hangzhou, China.
Fu
X M
XM
D000328:Adult; D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity*; D002869:Chromosome Aberrations; D006224:Cricetinae; D005260:Female; D006801:Humans; D008297:Male; D009152:Mutagenicity Tests; D013094:Spermatozoa / Q000187:drug effects* / Q000648:ultrastructure
D002246:Carbon Disulfide