[The neuromediator mechanism of the additive action of the delta sleep-inducing peptide in experimental audiogenic epilepsy caused by hypokinesia].
The DSIP influence on the rat cortex, thalamic and hypothalamic adrenaline, noradrenaline, DOPA, dopamine and serotonin level under normal, hypokinetic stress condition (1 h in duration) and experimental audiogenic epilepsy was studied. It was found, that a single intraperitoneal DSIP injection (12 microns/100 g body weigh, 1 h before placing the animals into the stress condition) prevented spontaneous epileptic activity development due to creation of optimal ratio between monoamines in brain structures.
Mendzheritskiĭ
A M
AM
Uskova
N I
NI
Lysenko
A V
AV
Revinskiĭ
Iu V
IuV
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000032:analysis; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004827:Epilepsy / Q000209:etiology / Q000378:metabolism*; D005260:Female; D018476:Hypokinesia / Q000150:complications / Q000378:metabolism*; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D013788:Thalamus / Q000737:chemistry / Q000187:drug effects
D002395:Catecholamines; D018377:Neurotransmitter Agents; D003701:Delta Sleep-Inducing Peptide
Neĭromediatornyĭ mekhanizm adaptivnogo deĭstviia del'ta-son indutsiruiushchego peptida pri éksperimental'noĭ audiogennoĭ épilepsii, vyzvannoĭ gipokinezieĭ.