[Augmented ability of spleen cells to produce interferons and prevention from lethal infection of herpes simplex virus in mice orally treated with Enterococcus faecalis preparation, FK-23].
Effects of the oral or intraperitoneal administration of an Enterococcus preparation, FK-23, to mice on the interferon (IFN) production by their spleen cells and on the host defense against the infection with herpes simplex virus (HSV)-1 were examined. Spleen cells were obtained from the mice intraperitoneally treated with cyclophosphamide (CY) and subsequently orally administered FK-23 preparation, and then cultured with phytohemagglutinin-P or bacterial lipopolysaccharide in vitro. They produced higher titers IFN than those obtained from control mice which were not treated with the FK-23 preparation. The IFN activity was neutralized mainly by antiIFN-beta antibody. Correspondingly, oral (5 mg/mouse) or intraperitoneal (1 mg/mouse) administration of the FK-23 preparation protected some of the CY-pretreated mice from death by HSV-1 infection.
Nohmi
T
T
Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie, Japan.
Abe
S
S
Katoh
M
M
Yamamoto
T
T
Yamaguchi
H
H
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000276:immunology*; D005260:Female; D006561:Herpes Simplex / Q000517:prevention & control*; D007113:Immunity, Innate / Q000187:drug effects*; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D008809:Mice, Inbred C3H; D018139:Simplexvirus / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000378:metabolism*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000494:pharmacology
D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated; D007372:Interferons