Subacute encephalopathic toxicity of cisplatin.
Acute blindness or seizures are usually the first signs of central neurotoxicity from cisplatin. We report a case of subacute neurotoxicity caused by cisplatin. Progressive encephalopathy and partial loss of vision were the main observed signs. This condition was completely reversible upon cisplatin discontinuation, as is usually the case with acute central neurotoxicity.
Verschraegen
C
C
M. D. Anderson Cancer Center, University of Texas, Houston 77030, USA.
Conrad
C A
CA
Hong
W K
WK
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001766:Blindness / Q000139:chemically induced*; D001927:Brain Diseases / Q000139:chemically induced* / Q000503:physiopathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D017294:Ondansetron / Q000008:administration & dosage
D016179:Granulocyte Colony-Stimulating Factor; D017294:Ondansetron; D005047:Etoposide; D002945:Cisplatin