title: Dopamine, dopexamine and dobutamine in liver transplant recipients: a comparison of their effects on hemodynamics, oxygen transport and hepatic venous oxygen saturation.
abstract: The purpose of this study was to determine the effects of vasoactive treatment with dopamine (DO), dopexamine (DX), and dobutamine (DOB) on hemodynamics, oxygen transport and hepatic venous oxygen saturation (SvhO2) after orthotopic liver transplantation (OLT). A pulmonary artery catheter was inserted into the right hepatic vein of 17 OLT patients. Timed infusion of DO, DX, and DOB was performed at the following rates: DO at 4 and 8 micrograms/kg per minute, DX at 4 and 8 micrograms/kg per minute, and DOB at 5 and 10 micrograms/kg per minute. Hemodynamics, oxygen transport variables, and SvhO2 were assessed. Each catecholamine induced a significant increase in cardiac index, oxygen delivery, and SvhO2. Mean arterial pressure was increased during DO and DOB, but significantly reduced during DX. Each inotrope increased oxygen delivery in parallel with SvhO2, suggesting a corresponding increase in hepatic oxygen supply. Therefore, it appears that each vasoactive drug may be utilized in OLT patients to provide oxygen delivery without impairment of splanchnic oxygenation.
authors.affiliation: Department of Anesthesiology & Intensive Care Medicine, Virchow Clinic, Humboldt University Berlin, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Kaisers
authors.forename: D
authors.initials: D
authors.lastname: Pappert
authors.forename: J M
authors.initials: JM
authors.lastname: Langrehr
authors.forename: H
authors.initials: H
authors.lastname: Undi
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries; D002302:Cardiac Output / Q000187:drug effects; D004280:Dobutamine / Q000494:pharmacology*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008102:Liver Circulation / Q000187:drug effects*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011651:Pulmonary Artery; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; C046318:dopexamine; D004280:Dobutamine; D010100:Oxygen; D004298:Dopamine