[The effect of cobalt chloride on hemoxygenase activity, on bilirubin metabolic homeostasis in the brain and on serum albumin transport function in animals].
Administration of cobalt chloride (everyday dosage 50-100 mumol/kg) to rats in the course of pregnancy and first two days of postnatal period increases the activity of hemoxygenase + NADPH biliverdinreductase enzyme system in the brain of adult rats and induce this activity in new-born rats. Functional activity of serum albumin connected with bilirubin transport, the pH value in blood and bilirubin concentration in the brain of adult and new-born rats virtually do not change, whereas bilirubin concentration in the serum of pregnant rats received CoCl2 raises. When the same doses of cobalt chloride are administered to pregnant rats in combination with the mixture of high fatty acids and acetylsalicylic acid the activity of this enzyme system in the brain increases, functional activity of serum albumin connected with bilirubin transport decreases, bilirubin concentration in the brain raised (serum bilirubin concentration being comparatively low) at the same pH value in blood of both pregnant and new-born rats.
Tkachenko
A V
AV
D000818:Animals; D000831:Animals, Newborn; D001663:Bilirubin / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003035:Cobalt / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000187:drug effects* / Q000378:metabolism
D012709:Serum Albumin; D003035:Cobalt; D006419:Heme Oxygenase (Decyclizing); C018021:cobaltous chloride; D001663:Bilirubin
Vliianie khlorida kobal'ta na aktivnost' gemoksigenazy, metabolicheskiĭ gomeostaz bilirubina v golovnom mozge i transportnuiu funktsiiu syvorotochnogo al'bumina u zhivotnykh.