title: [Familial erythermalgia treated with pizotifen].
abstract: BACKGROUND
  Primary erythermalgia is a rare acrosyndrome due to paroxystic arteriolar dilatation of extremities that become red and congested with warmth and burning sensation or pain.
  
  
  METHODS
  We report herein the observation of a primary erythermalgia affecting 3 degrees in the same family (grandfather, uncle/mother, and children with early onset at 6 years): pizotifene, an antiserotoninergic drug proved to be effective in mother and 14-year-old child who had never drawn benefit from any previous treatment.
  
  
  CONCLUSIONS
  Several etiologies may be responsible for erythermalgia according to the clinical type: primary erythermalgia with pediatric onset, and secondary erythermalgia as a reaction to myeloproliferation, other diseases, drug or heavy metal poisoning. Pathophysiology of primary erythermalgia is not clearly understood and the main concern is therapy: in this respect, pizotifene deserves to be considered as a valuable possibility.
authors.affiliation: Service de Dermatologie, CHU Brest.
authors.forename: M H
authors.initials: MH
authors.lastname: Guillet
authors.forename: E
authors.initials: E
authors.lastname: Le Noach
authors.forename: P
authors.initials: P
authors.lastname: Milochau
authors.forename: B
authors.initials: B
authors.lastname: Sassolas
authors.forename: G
authors.initials: G
authors.lastname: Guillet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D002648:Child; D004916:Erythromelalgia / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010918:Pizotyline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D010918:Pizotyline
vernacular_title: Erythermalgie familiale trait par pizotifé.