Prevalence of factor V Leiden in a Canadian blood donor population.
OBJECTIVE
To determine the prevalence of factor V Leiden in a Canadian blood donor population.


METHODS
Cross-sectional laboratory study.


METHODS
Hamilton Centre of the Canadian Red Cross Society.


METHODS
Volunteer donors who attended Hamilton Centre blood donor clinics over a 4-day period in August 1994; blood samples from 356 people were evaluable.


METHODS
Presence of factor V Leiden.


RESULTS
Factor V Leiden was detected in 19 of the 356 people, for a prevalence rate of 5.3% (95% confidence interval 3.0% to 7.6%). All 19 people were shown to be heterozygous for the mutation.


CONCLUSIONS
Factor V Leiden is common in the Canadian population. Its prevalence is similar to that reported in other Western countries. These data are relevant in the clinical management of patients at risk for venous thrombosis and those with recurrent thrombotic disorders.
Lee
D H
DH
Department of Pathology, McMaster University, Hamilton, Ont.
Henderson
P A
PA
Blajchman
M A
MA
D001483:Base Sequence; D001782:Blood Donors; D003430:Cross-Sectional Studies; D004247:DNA / Q000235:genetics*; D005165:Factor V / Q000032:analysis* / Q000235:genetics; D006580:Genetic Carrier Screening; D006801:Humans; D008969:Molecular Sequence Data; D009864:Ontario; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D013927:Thrombosis / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D004247:DNA