title: No association detected between a D3 receptor gene-expressed variant and schizophrenia.
abstract: A missense polymorphism (glycine to serine) in the first exon of the dopamine D3 (DRD3) gene was examined in the sib-pairs schizophrenia collection by the transmission test for linkage disequilibrium (TDT). No association due to linkage disequilibrium was detected using TDT. Additionally, no evidence for excess homozygosity was found.
authors.affiliation: Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892-1274, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Rothschild
authors.forename: J
authors.initials: J
authors.lastname: Badner
authors.forename: A
authors.initials: A
authors.lastname: Cravchik
authors.forename: E S
authors.initials: ES
authors.lastname: Gershon
authors.forename: P V
authors.initials: PV
authors.lastname: Gejman
mesh_terms: D005838:Genotype; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3