title: Interchange between collagenous and lymphocytic colitis in severe disease with autoimmune associations requiring colectomy: a case report.
abstract: BACKGROUND
  Collagenous colitis and lymphocytic colitis present with a similar clinical picture. Whether these conditions are separate entities or whether they represent different pathological stages of the same condition is an unresolved issue.
  
  
  METHODS
  This is a case of collagenous colitis following a fulminant course in which a colectomy was necessary. In the operative specimen the thickened collagen plate, which had been present only two weeks preoperatively had been lost and the pathology was of a lymphocytic colitis. Six months postoperatively this patient developed a CREST syndrome and primary biliary cirrhosis.
  
  
  CONCLUSIONS
  This case shows the lability of the collagen plate and the common ground between collagenous and lymphocytic colitis, and presents evidence that these two conditions are different manifestations of the same disease. It also describes for the first time an association between collagenous colitis and CREST syndrome and primary biliary cirrhosis.
authors.affiliation: Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.
authors.forename: T E
authors.initials: TE
authors.lastname: Bowling
authors.forename: A B
authors.initials: AB
authors.lastname: Price
authors.forename: M
authors.initials: M
authors.lastname: al-Adnani
authors.forename: P D
authors.initials: PD
authors.lastname: Fairclough
authors.forename: N
authors.initials: N
authors.lastname: Menzies-Gow
authors.forename: D B
authors.initials: DB
authors.lastname: Silk
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications; D017675:CREST Syndrome / Q000150:complications*; D003082:Colectomy; D003092:Colitis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D003095:Collagen Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications; D008875:Middle Aged