Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation.
Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.
Brownell
J E
JE
Department of Biology, University of Rochester, New York 14627-0211, USA. jb@allislab.biology.rochester.edu
Allis
C D
CD
D000107:Acetylation; D000123:Acetyltransferases / Q000502:physiology*; D000595:Amino Acid Sequence; D002843:Chromatin / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D051548:Histone Acetyltransferases; D006657:Histones / Q000378:metabolism; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins; D015533:Transcriptional Activation
D002843:Chromatin; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases