[Experimental study of R plasmid eliminating action of Coptis chinensis on E. coli].
The R plasmid curing experiment was performed in vitro with E. coli strain E. 102 bearing R plasmid as target bacteria and Coptis chinensis as elimination agent. The influence of different time on R plasmid elimination was also observed. Results showed that when the acting time was 24 hours, the cure rate of R plasmid was 2.42% and when the acting time increased to 48 hours, the cure rate elevated to 22.57%. The Missing patterns of R plasmid might be occurred in disappearence of either multiple or single resistance.
Chen
Q
Q
Department of Microbiology, Guangdong Medical College, Zhanjiang.
Chen
N J
NJ
Wang
S C
SC
D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics*; D011815:R Factors / Q000187:drug effects*; D013997:Time Factors
D004365:Drugs, Chinese Herbal