Nutritional and hormonal regulation of fatty acid synthase.
Fasting causes a decrease in the rate of synthesis of fatty acid synthase, the central enzyme in fatty acid synthesis, while refeeding carbohydrate increases synthesis. Insulin also increases the synthesis of fatty acid synthase, while glucagon causes a decline. The mechanism was shown to be transcriptional activation-mediated through a 2.1-kb stretch of the 5'-flanking sequence of the fatty acid synthase gene promoter that contains an insulin response element. These effects were confirmed by in vivo experiments with transgenic mice.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D000818:Animals; D064429:Fatty Acid Synthases / Q000096:biosynthesis* / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D009747:Nutritional Physiological Phenomena
D006728:Hormones; D064429:Fatty Acid Synthases