title: Comparative analysis of the attachment protein gene (H) of dolphin morbillivirus.
abstract: DMV, dolphin morbillivirus, a paramyxovirus of uncertain origin recently emerged in Mediterranean dolphins. This study presents the complete nucleotide sequence of the hemagglutinin (H) gene including the gene boundaries. The single open reading frame of the DMV H gene encodes a protein of 604 residues which exhibits overall sequence characteristics similar to the H genes of other morbilliviruses. When compared to its closest homologues, measles virus (MV) and rinderpest virus (RPV), DMV has, respectively, 44 and 46% of amino acid residues in identical positions. The primary sequence of the DMV H protein is markedly less conserved than that of the fusion protein. The comparative data at the genomic level correspond with cross-neutralization studies with different morbilliviruses. Retrospective serogical studies dating back to 1983 indicate DMV-like infections in whales of the eastern Atlantic. The presented data support and extend previous studies suggesting that this novel morbillivirus is one of the phylogenetically oldest morbilliviruses known to circulate today. The relationship of DMV and established morbilliviruses to the newly emerged candidate morbillivirus infecting horse and man is discussed.
authors.affiliation: Laboratory of Virology and Immunology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Blixenkrone-Møller
authors.forename: G
authors.initials: G
authors.lastname: Bolt
authors.forename: T D
authors.initials: TD
authors.lastname: Jensen
authors.forename: T
authors.initials: T
authors.lastname: Harder
authors.forename: V
authors.initials: V
authors.lastname: Svansson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001483:Base Sequence; D004279:DNA, Viral; D004289:Dolphins / Q000821:virology*; D006389:Hemagglutinins, Viral / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D018103:Morbillivirus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D010802:Phylogeny; D012333:RNA, Messenger; D012367:RNA, Viral; D017386:Sequence Homology, Amino Acid
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; C104413:H protein, Dolphin morbillivirus; D006389:Hemagglutinins, Viral; D012333:RNA, Messenger; D012367:RNA, Viral