title: Different effects of acute administration of aminophylline and nitroglycerin on exercise capacity in patients with syndrome X.
abstract: To investigate the effects of the acute administration of aminophylline and nitroglycerin on effort ischemia, 20 patients with syndrome X underwent 3 bicycle exercise tests after sublingual nitroglycerin (0.3 mg) and after 90 minutes of oral administration of aminophylline (400 mg). Compared with the basal test, only aminophylline induced a significant increase in the time to ischemic threshold and to angina; these findings support the potential therapeutic role of this adenosine receptor blocking agents and suggest a possible role of "steal phenomenon" in the pathogenesis of effort angina in patients with syndrome X.
authors.affiliation: Clinical Methodology, University of Milan, Division of Cardiology, Seriate, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Radice
authors.forename: V
authors.initials: V
authors.lastname: Giudici
authors.forename: E
authors.initials: E
authors.lastname: Pusineri
authors.forename: L
authors.initials: L
authors.lastname: Breghi
authors.forename: T
authors.initials: T
authors.lastname: Nicoli
authors.forename: P
authors.initials: P
authors.lastname: Peci
authors.forename: P
authors.initials: P
authors.lastname: Giani
authors.forename: L
authors.initials: L
authors.lastname: De Ambroggi
mesh_terms: D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000503:physiopathology*; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D018047:Receptors, Purinergic P1 / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002316:Cardiotonic Agents; D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D000628:Aminophylline; D005996:Nitroglycerin