The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer.
Quantitative analysis of the proteins which compromise the stimulatory arm of the adenylyl cyclase cascade indicate that the adenylyl cyclase catalytic component is usually the least highly expressed. The effects on both potency of agonist ligands and maximal output resulting from targetted alterations in expression levels of each element of this cascade are discussed.
Milligan
G
G
Division of Biochemistry and Molecular Biology, University of Glasgow, Scotland, U.K.
D000262:Adenylyl Cyclases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
D000262:Adenylyl Cyclases