title: Idiopathic CD4+ lymphocytopenia and systemic vasculitis.
abstract: The syndrome defined as "idiopathic CD4 lymphocytopenia' (ICL) is a rare disease of unknown aetiology, often associated with severe depression of immune defences and the occurrence of opportunistic infections. A case is reported wherein a severe immunodeficiency syndrome with persistent idiopathic CD4+ lymphopenia developed in a woman suffering from systemic microscopic polyarteritis; no signs of HIV 1/2 or HTLV I/II infection were evident. The patient died of widespread opportunistic infections. The association of ICL with vasculitis has never been reported until now. A link between the two diseases cannot be ruled out.
authors.affiliation: II Divisione di Medicina Generale, Ospedale Maggiore, Novara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bordin
authors.forename: M
authors.initials: M
authors.lastname: Ballaré
authors.forename: S
authors.initials: S
authors.lastname: Paglino
authors.forename: P
authors.initials: P
authors.lastname: Ravanini
authors.forename: D
authors.initials: D
authors.lastname: Dulio
authors.forename: M C
authors.initials: MC
authors.lastname: Malosso
authors.forename: R
authors.initials: R
authors.lastname: Boldorini
authors.forename: A
authors.initials: A
authors.lastname: Monteverde
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009894:Opportunistic Infections / Q000150:complications* / Q000276:immunology; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000276:immunology / Q000473:pathology; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies