Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone.
We analysed the relationship between free 2,5-hexanedione (2,5-HD) and total 2,5-HD in the urine of 87 workers exposed to n-hexane and other solvents (hexane isomers, acetone and toluene), in relation to different working conditions. The concentration of free 2,5-HD in urine of workers exposed to n-hexane was about 12% of total urinary 2,5-HD. The most significant correlation (r = 0.936) was that of total 2,5-HD in urine with environmental n-hexane and exhaled air. With equal exposure to n-hexane, the concentrations in urine of free and total 2,5-HD increased when cutaneous absorption was involved (gloves not used), during the working week and with co-exposure to acetone. An analysis of the relationship between combined exposure to acetone and urinary concentrations of the various forms of 2,5-HD suggests that acetone might influence the toxicokinetics of n-hexane, increasing the proportion of free 2,5-HD.
Cardona
A
A
Department of Toxicology and Legal Medicine, Alicante University, Alicante, Spain.
Marhuenda
D
D
Prieto
M J
MJ
Martí
J
J
Periago
J F
JF
Sánchez
J M
JM
D000096:Acetone / Q000032:analysis* / Q000493:pharmacokinetics; D001944:Breath Tests; D004347:Drug Interactions; D004784:Environmental Monitoring; D006586:Hexanes / Q000032:analysis* / Q000493:pharmacokinetics; D006588:Hexanones / Q000652:urine*; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis*
D006586:Hexanes; D006588:Hexanones; D000096:Acetone; C026385:n-hexane; C011269:2,5-hexanedione