[Effect of sevoflurane on release of TNF-alpha and IL-1 beta from human monocytes].
Although isoflurane inhibits TNF-alpha and IL-1 beta release from human monocytes stimulated by LPS in dose dependent fashion, it is unclear whether sevoflurane has the same effects. Therefore, we investigated whether sevoflurane could inhibit TNF-alpha and IL-1 beta secretions from human monocytes stimulated by LPS in dose dependent fashion in vitro. Human monocytes stimulated by LPS were cultured for 3 h in the presence of sevoflurane 1% or 5%. Another group of human monocytes were cultured in the absence of sevoflurane. TNF-alpha and IL-1 beta increased after stimulation of LPS and these increases were not inhibited by sevoflurane in a dose dependent fashion. We conclude that sevoflurane does not inhibit TNF-alpha and IL-1 beta release from monocytes stimulated by LPS.
Sato
W
W
Department of Anesthesiology, Akita University School of Medicine, Japan.
Enzan
K
K
Mitsuhata
H
H
Masaki
Y
Y
Kayaba
M
M
Suzuki
M
M
D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics / Q000494:pharmacology*; D002478:Cells, Cultured; D004987:Ethers / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism*; D008738:Methyl Ethers; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D000077149:Sevoflurane; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D018685:Anesthetics, Inhalation; D004987:Ethers; D007375:Interleukin-1; D008738:Methyl Ethers; D014409:Tumor Necrosis Factor-alpha; D000077149:Sevoflurane