title: Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.
abstract: In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carinii pneumonia.
authors.affiliation: Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016, USA.
authors.forename: S
authors.initials: S
authors.lastname: Merali
authors.forename: K
authors.initials: K
authors.lastname: Chin
authors.forename: R W
authors.initials: RW
authors.lastname: Grady
authors.forename: A B
authors.initials: AB
authors.lastname: Clarkson
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003676:Deferoxamine / Q000097:blood* / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology; D011010:Pneumocystis / Q000187:drug effects* / Q000502:physiology; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000382:microbiology; D051381:Rats
chemical_list: D000935:Antifungal Agents; D003676:Deferoxamine