Cutaneous manifestations of congenital afibrinogenaemia.
Skin problems from coagulation disorders have rarely been described in the dermatological literature. Here we report a patient with a complete congenital absence of fibrinogen which led to leg ulceration, necrosis of the toes and a life-threatening haemorrhage following skin biopsy. This patient shows that leg ulcers may have a complex aetiology and can reflect serious underlying disease.
Rupec
R A
RA
Department of Dermatology, University of Munich, Germany.
Kind
P
P
Ruzicka
T
T
D000328:Adult; D000347:Afibrinogenemia / Q000150:complications* / Q000151:congenital; D005260:Female; D006801:Humans; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology