[Experimental research on using macromolecule sodium hyaluronate to prevent flexior tendon adhesion].
With chicken paw as an animal model, we studied the effects of sodium hyaluronate product (SHP) on the heal of injured tendon and the formation of post-surgical tendon adhesions. The function of digit flexion angle and moving function of the tendon in SHP group were remarkably superior to those of tendons in physiological salt solution control group (P < 0.01). Tendons of the experiment group healed well, their surface was smooth without adhesion. False sheath was formed around the tendon, and there was also a gap between the false sheath and the tendon. However, the adhesion between the tendon and its surrounding tissue in the control group was donse with clear boundary. These results suggest that SHP has a protective effect against the formation of adhesion in healing tendon.
Chen
Z
Z
People's Liberation Army Air Force, Shanghai First Hospital.
Gu
J
J
D000818:Animals; D002645:Chickens; D005260:Female; D006820:Hyaluronic Acid / Q000737:chemistry / Q000627:therapeutic use*; D046911:Macromolecular Substances; D009135:Muscular Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons / Q000601:surgery / Q000648:ultrastructure; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D046911:Macromolecular Substances; D006820:Hyaluronic Acid