title: The development of preatherosclerotic coronary artery lesions in perinatal piglets.
abstract: The fine structure and ultrastructure of the anterior descending coronary artery were studied in a series of perinatal piglets at 1 week prior to birth, and at 8, 24, 72 and 168 h after birth. In the anterior descending coronary artery, at or just distal to the branch point of the left circumflex artery, early plaque-like intimal lesions were present in the majority of animals. These consisted of subendothelial edema, fragmentation and dissolution of the internal elastic lamella, and the appearance of intimal myoid cells known as modified smooth muscle cells (MSMCs). These changes were present in all piglets at and before 8 h of age. They persisted and progressed during the first week of life in about half of the piglets. Beginning at 72 h and continuing through 168 h, there was an increase in MSMCs and the appearance of fibroblasts. Both fibroblasts and MSMCs were associated with the elaboration of dense collagen fibrils. Foamy macrophages appeared within the subendothelial intima having the appearance of lipophages. While the prevalence of these changes at birth indicates that they may be part of normal development, their persistence in half the piglets and structural features suggest reaction to intimal injury beginning prenatally. The lesions may be precursive of coronary atherosclerosis later in life and may parallel the early stages of atherogenesis in humans.
authors.affiliation: Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, NC 27858-4354, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Bolande
authors.forename: E A
authors.initials: EA
authors.lastname: Leistikow
authors.forename: F S
authors.initials: FS
authors.lastname: Wartman
authors.forename: T M
authors.initials: TM
authors.lastname: Louis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001161:Arteriosclerosis / Q000196:embryology / Q000473:pathology*; D003331:Coronary Vessels / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure*; D005333:Fetus; D024510:Muscle Development; D009131:Muscle, Smooth, Vascular / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure; D013552:Swine