The effect of the reconstitution medium on aggregation of lyophilized recombinant interleukin-2 and ribonuclease A.
Zhang
M Z
MZ
Department of Protein Chemistry Amgen Inc., Amgen Center, Thousand Oaks, California 91320, USA.
Pikal
K
K
Nguyen
T
T
Arakawa
T
T
Prestrelski
S J
SJ
D000818:Animals; D002021:Buffers; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004356:Drug Storage / Q000592:standards; D005612:Freeze Drying; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007376:Interleukin-2 / Q000378:metabolism*; D011485:Protein Binding; D011994:Recombinant Proteins / Q000378:metabolism; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*; D013696:Temperature
D002021:Buffers; D007376:Interleukin-2; D011994:Recombinant Proteins; D012259:Ribonuclease, Pancreatic