Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: an ultrasonographic study.
An ultrasonographic study of ten healthy volunteers was carried out to evaluate the effect of cisapride on gastric antral emptying. More than 1 week after the measurement of the baseline emptying rate, cisapride was given at a single oral dose of 5 mg 30 minutes before intake of a balanced liquid test meal (5 ml/kg body weight). To determine the time to half emptying (T1/2), an exponential curve was extrapolated for the elimination phase of the gastroantral sagittal cross-sectional area plotted against time. The T1/2 was reduced by 18.5% after cisapride, from 62.6 +/- 4.3 to 51.0 +/- 4.4 min (P = 0.0284). We conclude that a single oral dose of 5 mg of cisapride significantly accelerates the gastric antral emptying rate in healthy humans.
Takeda
T
T
First Department of Surgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Konomi
H
H
Naritomi
G
G
Yoshida
J
J
Matsunaga
H
H
Akazawa
K
K
Tanaka
M
M
D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D020117:Cisapride; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013270:Stomach / Q000000981:diagnostic imaging; D014463:Ultrasonography
D000897:Anti-Ulcer Agents; D010880:Piperidines; D020117:Cisapride