[Experimental studies on the pharmacokinetics of cefoperazone (CPZ) injection under burn eschar].
In this study, the rabbits were categorized into three groups. The scald (III degrees TBS 10%-15%) was caused by exposing these area to hot water at 90 degrees C for 40 seconds. Every rabbit was injected CPZ (25 mg/kg) three times. The changes in the concentration of CPZ were measured by employing MBPD and HPLC methods and experimental data were analyzed by using pharmacokinetic computer program.


RESULTS
1) The T1/2e of CPZ injection in subeschar region was longer and the Cmax was higher than that of intravenous route. 2) The concentration in blood was shown two times higher than after subeschar injection. 3) The levels of concentration were higher than MIC'S in an area of 6.5 cm diameter 24-36 hours after injection.


CONCLUSIONS
CPZ injection in subeschar region was the best route of treatment and prevention of subeschar infection.
Han
F
F
Department of Emergency and Burn, Xijing Hospital, Fourth Military Medical University, Xian.
Chen
B
B
Fang
J
J
D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000378:metabolism*; D002438:Cefoperazone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D015552:Injections, Intralesional; D008297:Male; D011817:Rabbits; D014946:Wound Infection / Q000517:prevention & control
D002511:Cephalosporins; D002438:Cefoperazone