[The effect of estradiol, norethisterone and testosterone on regional circulation and relative weight of the testes, ovaries and uterus in rats].
In nine experiments of 188 rats (85 males and 103 females), relative weight and local blood flow (with 85Sr-microspheres) was estimated in testes, ovaries and uterus after the administration of estradiol benzoate (Agofollin Depot 1 mg per rat or 5 mg per kg s.c. in time intervals of 3 to 7 days), norethisterone (Norethisterone tablets 0.01 or 0.02% in the food) or testosterone (Agovirin Depot 25 mg per kg s.c. every 5 days); all preparations were administered for four weeks. With one exception (norethisterone in males), the results of two experiments performed in the same manner are presented in every experimental situation. After estradiol, the body weight of rats in both sexes is lowered, relative weight of the uterus increased. The local circulatory indicators i.e. 85Sr-microsphere uptake in % dose per g, blood flow in (ml.min-1).g-1 and organ flow fraction % of cardiac output are decreased in the testes and unchanged on the ovaries. As regards the uterus, in the first experiment the 85Sr-microsphere uptake and the blood flow is significantly lower, in the second experiment these values remain unchanged and flow fraction is increased due to enlargement of the uterus. Norethisterone lowers the body weight and relative weight of the testes; in one experiment it increases relative weight of the uterus. Local circulatory indicators are decreased in the testes and inconstantly in the ovaries, whereas in the uterus the decreases are insignificant. Testosterone does not change the body weight. In one experiment, it increases the cardiac output per 100g of body weight; relative weight of the testes is lowered in one experiment and in the ovaries in both experiments, and markedly increased in the uterus. Local circulatory indicators were decreased in the testes, ovaries and uterus but approximately one half of the differences are significant. Thus, with one exception, all statistically significant local circulatory changes after the administration of the hormonal preparations are decreasing; the suppressive action is evident in the local circulation in sexual organs of the animals of the corresponding sex as well as in animals of the other sex. The suppression of the local circulation in testes and ovaries is probably in connection with endocrine regulations; the decrease of microsphere uptake and blood flow per g in the uterus may participate in insufficient adaptation of the blood supply in the enlargement of the uterus after four weeks' administration of estradiol and testosterone.
Kapitola
J
J
Laborator pro endokrinologii metabolismus 1. lékarská fakulta University Karlovy, Praha, Czech Rebublic.
Andrle
J
J
Kubícková
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D009640:Norethindrone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology / Q000098:blood supply / Q000187:drug effects*; D045167:Progesterone Congeners / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology / Q000098:blood supply / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology / Q000098:blood supply / Q000187:drug effects*
D045167:Progesterone Congeners; D013739:Testosterone; D004958:Estradiol; D009640:Norethindrone
Vliv estradiolu, norethisteronu a testosteronu na místní krevnií obĕh a relativiní hmotnost varlat, vajećníků a dĕlohy potkanů.