Hepar lobatum carcinomatosum due to chemotherapy of a metastatic breast carcinoma.
Besides the lungs, the liver is the second most common site of hematogenous metastases from carcinomata of the breast. Hepar lobatum carcinomatosum is the rarest form of metastatic liver disease. Reported in this article is a case of a 59-year-old woman with invasive duct carcinoma of the breast with metastasis to the axillar lymph nodes and liver, treated with ablatio mammae and combination of chemotherapy. The etiology of hepar lobatum is caused by multiple pathogenetic factors. Tumor-related multifocal obstruction of portal and hepatic venous vessels and effects of chemotherapy are discussed.
Uhlmann
F
F
Department of Pathology, Lichtenberg Hospital Berlin, Germany.
Martin
H
H
Ringk
H
H
Krocker
J
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy / Q000556:secondary*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed