[Intracerebroventricular injection of interleukin 1 receptor antagonist antagonises on the generation of immuno-suppressive factor in restraint mice].
Our previous work showed that a lymphocyte proliferation suppressing factor could be found in the serum of restraint mice. In the present work, it was found that intracerebroventricular (icv) injection of IL-1 receptor antagonist (IL-1Ra) was found capable of suppressing the production of such a serum protein under restraint stress. Nearly complete suppression could be achieved by 5.0 micrograms IL-1Ra. Intracerebroventricular injection of IL-1 beta (1 pg), however, increased the generation of the supressive protein. Neither intraperitoneal (ip) injection of IL-1Ra or IL-1 beta had any effect on the generation of the protein. The fact that icv. injection of a very small dose of IL-1 beta (0.06 fmol) was effective on the generation of the supressive protein led us to suggest that IL-1 in brain might act as an important mediator between CNS and the immune system.
Zuo
Y C
YC
Department of Immunology, Beijing Medical University.
Li
Y F
YF
Liu
W
W
Deng
Y L
YL
Huang
D W
DW
Mei
L
L
Fan
S G
SG
Ding
G F
GF
D000818:Animals; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012149:Restraint, Physical; D013312:Stress, Physiological; D013491:Suppressor Factors, Immunologic / Q000096:biosynthesis*
D007375:Interleukin-1; D008222:Lymphokines; D017472:Receptors, Interleukin-1; D013491:Suppressor Factors, Immunologic