title: Transcriptional control: how nuclear receptors get turned on.
abstract: The recently determined structures of the ligand-binding domains from three nuclear receptors show that a receptor undergoes a significant conformational change on ligand binding. It is not yet clear how this structural change results in transcriptional activation.
authors.affiliation: Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Schwabe
mesh_terms: D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008024:Ligands; D011487:Protein Conformation; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry* / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000737:chemistry / Q000378:metabolism; D047488:Retinoid X Receptors; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D015533:Transcriptional Activation; D000097768:Retinoic Acid Receptor gamma
chemical_list: D004268:DNA-Binding Proteins; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors; D000097768:Retinoic Acid Receptor gamma