title: In vivo inflammatory response to silicone elastomer particulate debris.
abstract: Silicone elastomer particles (Silastic silicone elastomer, Dow Corning, Midland, MI), polymethylmethacrylate particles, and monosodium urate particles smaller than 10 microns were injected into a rat subcutaneous air pouch lined with synovial membrane-like cells. Inflammatory exudate from the air pouch was retrieved at 6 hours, 24 hours, 48 hours, and 72 hours after injection. White blood cell count, tumor necrosis factor, and prostaglandin E2 were measured in the exudate. White blood cell and tumor necrosis factor levels in the exudate were the highest for the silicone group at 6 and 24 hours. Prostaglandin E2 was also significantly higher in the silicone group at 24 hours. We conclude that the acute inflammation is particle-type specific and that Silicone elastomer particles are acutely inflammatory.
authors.affiliation: Department of Orthopaedic Surgery, Pennsylvania State University, Hershey, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Naidu
authors.forename: P
authors.initials: P
authors.lastname: Beredjiklian
authors.forename: L
authors.initials: L
authors.lastname: Adler
authors.forename: F W
authors.initials: FW
authors.lastname: Bora
authors.forename: D G
authors.initials: DG
authors.lastname: Baker
mesh_terms: D000818:Animals; D005384:Finger Joint / Q000473:pathology / Q000601:surgery*; D005549:Foreign-Body Reaction / Q000473:pathology*; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D012826:Silicone Elastomers; D013583:Synovial Membrane / Q000473:pathology
chemical_list: D012826:Silicone Elastomers