[Effect of yougui yin on the content of monoaminic transmitters and body weight, food and fluid intake in corticosterone-rats].
Great attention has been paid to the relationship between the central monoaminic transmitters and the hypothalamus-pituitary-adrenal (HPA) axis recently. This paper reported the content of hypothalamic monoaminic transmitters of rats, which were injected with corticosterone 10 mg/kg subcutaneously for 14 days. The body weight as well as volume of food and fluid intake were measured in the same period. Effect of Yougui Yin (YGY, administrated by gastrogavage) on he cortico-inhibited rats was also observed. Results showed that the contents of hypothalamic monoaminic transmitters such as norepinephrine, Dopamine, 3,4-Dihydroxyphenylalanine, serotonin, and 5-hydroxyindole acetic acid of the rats increased obviously, while the body weight, volume of food and fluid intake decreased significantly day by day. The YGY could improve the above-mentioned indexes significantly. It suggested that: (1) The synthesis and metabolism of the central monoaminic transmitters of rats activated when the HPA axis was inhibited by exogenous glucocorticoid, their body weight lowered, and the volume of food and fluid intake decreased. (2) YGY could improve the inhibited HPA axis, and inhibit the activated central monoaminic transmitters as well as protect the normal regulating function of hypothalamus on food and fluid intake.
Cai
D F
DF
Institute of Integrated Traditional and Western Medicine, Shanghai Medical University.
Shen
Z Y
ZY
Zhang
L J
LJ
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000494:pharmacology*; D004326:Drinking; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004435:Eating; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D015306:Biogenic Monoamines; D004365:Drugs, Chinese Herbal; D006897:Hydroxyindoleacetic Acid; D003345:Corticosterone