title: Biokinetic behavior of technetium-99m-DMSA in children.
abstract: After intravenous administration of 99mTc-DMSA, biokinetic data were collected from studies on 24 children aged from 5 wk to 14.8 yr (15 normal and 9 with renal pathology).
  
  
  METHODS
  Patients were imaged with a gamma camera up to 30 hr postinjection and the absolute activities in the kidneys, liver, spleen, bladder, knees and whole body were estimated using an attenuation-corrected conjugate counting technique. Renal uptake and elimination rates and urinary excretion of radioactivity were also measured.
  
  
  RESULTS
  In children with normal renal function, maximal kidney uptake was 42.4% +/- 5.4% and was taken up with a half-time of 1.0 +/- 0.2 hr. Renal excretion amounted to 18.0% +/- 4.4% at 24 hr and was lowest in children aged less than 1 yr. In children with abnormal renal function, apart from the expected reduction in renal uptake there was evidence of wider variations in uptake rate and increased urinary excretion. Mean uptakes in liver and spleen were approximately 5% and 2%, respectively, in all patients and uptake in knees, assumed to reside in the metaphyseal growth complexes, was 1.4%.
  
  
  CONCLUSIONS
  In children with normal renal function, there was little evidence of age-dependent biokinetic factors other than reduced urinary excretion and lower uptake in knees in children aged less than 1 yr. The results therefore suggest that a single biokinetic model may suffice for radiation dosimetry purposes in normal children irrespective of age.
authors.affiliation: Department of Medical Physics, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
authors.forename: K
authors.initials: K
authors.lastname: Evans
authors.forename: M F
authors.initials: MF
authors.lastname: Lythgoe
authors.forename: P J
authors.initials: PJ
authors.lastname: Anderson
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: I
authors.initials: I
authors.lastname: Gordon
mesh_terms: D000367:Age Factors; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism; D004113:Succimer / Q000493:pharmacokinetics; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer