Clinical relevance of hepatitis C virus quasispecies.
It has been shown that hepatitis C virus (HCV) populations in infected individuals are composed of quasispecies with diverse mutations. The analysis of these variants may reveal mechanisms of the persistence of HCV infection, carcinogenesis and resistance to antiviral therapy. Recently, genetic features of interferon-resistant HCV have been elucidated through the analysis of interferon-resistant quasispecies, making it possible to predict interferon efficacy by detecting interferon-resistant strains.
Enomoto
N
N
Second Department of Internal medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Sato
C
C
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D014644:Genetic Variation; D016174:Hepacivirus / Q000235:genetics* / Q000502:physiology; D006526:Hepatitis C / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000821:virology; D018807:Polymorphism, Single-Stranded Conformational; D017735:Virus Latency / Q000502:physiology
D000998:Antiviral Agents; D007372:Interferons