title: No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees.
abstract: Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders. We have analyzed seven Italian families with schizophrenia and four families with bipolar disorders for a total of 68 individuals; 32 individuals were affected. Diagnoses were made using the structured clinical interview Schedule for Affective Disorders and Schizophrenia, Lifetime version (SADS-L). The results of our study provide no evidence of linkage between alleles at D2 dopamine receptor loci and schizophrenia or bipolar disorders. The markers TH gene and MAO-A gene give slightly positive or negative results suggesting the utility of further analysis on more informative families.
authors.affiliation: Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Firenze, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Grassi
authors.forename: M
authors.initials: M
authors.lastname: Mortilla
authors.forename: L
authors.initials: L
authors.lastname: Amaducci
authors.forename: S
authors.initials: S
authors.lastname: Pallanti
authors.forename: A
authors.initials: A
authors.lastname: Pazzagli
authors.forename: F
authors.initials: F
authors.lastname: Galassi
authors.forename: B M
authors.initials: BM
authors.lastname: Guarnieri
authors.forename: C
authors.initials: C
authors.lastname: Petruzzi
authors.forename: F
authors.initials: F
authors.lastname: Bolino
authors.forename: L
authors.initials: L
authors.lastname: Ortenzi
authors.forename: R
authors.initials: R
authors.lastname: Nistico
authors.forename: S
authors.initials: S
authors.lastname: De Cataldo
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Sorbi
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D008040:Genetic Linkage; D006801:Humans; D007558:Italy; D008995:Monoamine Oxidase / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2; D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase