[Effects of chemotherapy on the basis of the results of MTT assay for patients with gastrointestinal cancer].
The chemosensitivity test should be performed to individualize the chemotherapy for patients with gastrointestinal cancer, which is one of the tumors most refractory to treatment by anticancer drugs. The present study was designed to determine the chemosensitivity in fresh human gastrointestinal cancer, using highly purified tumor cells, and the correlation of this sensitivity with clinical response. The clinical responses were obtained in 15 of the 25 patients, and 5 of the 15 patients with gastric cancer and colorectal cancer, respectively. The inhibition rates for anticancer drugs in responders were higher than in nonresponders. Thus, it is suggested that the chemotherapy according to the results of the MTT assay is effective in patients with gastrointestinal cancer.
Yamaue
H
H
Second Department of Surgery, Wakayama Medical School, Japan.
Tanimura
H
H
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002945:Cisplatin / Q000494:pharmacology / Q000627:therapeutic use; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005047:Etoposide / Q000494:pharmacology / Q000627:therapeutic use; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology / Q000627:therapeutic use; D011446:Prospective Studies; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D016685:Mitomycin; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil