Antifertility effects of an LHRH agonist in male mice.
This study was designed to investigate the effects of repeated high doses of an LHRH agonist on Swiss porton mouse seminiferous epithelium. Seminiferous epithelium showed more pronounced degenerative effects at the higher dose (1000 micrograms/kg wt/day) of the drug, with arrest of spermatogenesis at all stages of differentiation; effects on spermatogenesis become more evident after pachytene spermatocyte stage. The decrease in the testis-specific enzyme LDH-X is accounted for by the decrease in the number of cells of gametogenic origin. Although complete azoospermia was not observed, acute inhibition of motility of spermatozoa may account for severely decreased fertility rates after mating. However, reduced fertility rates due to decreased libido as a consequence of diminished testosterone levels cannot be discounted.
Kher
R
R
Centre for Endocrine Sciences, Sanjay Gandhi PG Institute of Medical Sciences, Lucknow, India.
Kalla
N R
NR
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D002064:Buserelin / Q000008:administration & dosage / Q000494:pharmacology; D003272:Contraceptive Agents, Male; D004822:Epididymis / Q000166:cytology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D012670:Seminiferous Epithelium / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000166:cytology / Q000201:enzymology
D003272:Contraceptive Agents, Male; D015096:3-Hydroxysteroid Dehydrogenases; D007770:L-Lactate Dehydrogenase; D002064:Buserelin