title: Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family.
abstract: 1. VP and OT mediate their wealth of effects via 4 receptor subtypes V1a, V1b, V2, and OT receptors. 2. We here review recent insights in the pharmacological properties, structure activity relationships, species differences in ligand specificity, expression patterns, and signal transduction of VP/OT receptor. 3. Furthermore, the existence of additional VP/OT receptor subtypes is discussed.
authors.affiliation: Department of Medical Pharmacology, Utrecht University, Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Peter
authors.forename: H
authors.initials: H
authors.lastname: Burbach
authors.forename: R A
authors.initials: RA
authors.lastname: Adan
authors.forename: S J
authors.initials: SJ
authors.lastname: Lolait
authors.forename: F W
authors.initials: FW
authors.lastname: van Leeuwen
authors.forename: E
authors.initials: E
authors.lastname: Mezey
authors.forename: M
authors.initials: M
authors.lastname: Palkovits
authors.forename: C
authors.initials: C
authors.lastname: Barberis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008024:Ligands; D008959:Models, Neurological; D008969:Molecular Sequence Data; D010802:Phylogeny; D017433:Protein Structure, Secondary; D018045:Receptors, Oxytocin / Q000737:chemistry / Q000502:physiology*; D017483:Receptors, Vasopressin / Q000737:chemistry / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014667:Vasopressins / Q000494:pharmacology / Q000502:physiology*
chemical_list: D008024:Ligands; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D014667:Vasopressins