title: A percutaneously accessible pulsatile left ventricular assist device: modified assist device type 5.
abstract: To provide percutaneous access, a new circulatory assist system was developed. We call this newly developed system the modified assist device (MAD). The system is composed of a sac-type blood pump and cannula. Inflow and outflow valves are mounted in the apex and at the side wall 10 cm from the apex of the cannula, respectively. During systole, the blood is sucked from the left ventricle through the inflow valve of the cannula connected to the blood pump, and during diastole, the blood is ejected to the root of the aorta through the outflow valve. In vitro and in vivo evaluations of the pump performance were performed. The maximum flow rate of 1.9 L/min was obtained in the mock circulatory system. In our animal experiment, effective systolic unloading and diastolic augmentation were observed by activation of this system during regular sinus rhythm. In conclusion, the MAD-5 is thought to be percutaneously accessible and increases systemic and coronary flow.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical College, Daini Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Imanishi
authors.forename: K
authors.initials: K
authors.lastname: Imachi
authors.forename: H
authors.initials: H
authors.lastname: Yoshito
authors.forename: T
authors.initials: T
authors.lastname: Isoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Chinzei
authors.forename: K
authors.initials: K
authors.lastname: Mabuchi
authors.forename: K
authors.initials: K
authors.lastname: Kanda
authors.forename: N
authors.initials: N
authors.lastname: Tsutsui
authors.forename: K
authors.initials: K
authors.lastname: Suma
authors.forename: I
authors.initials: I
authors.lastname: Fujimasa
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000502:physiology; D002404:Catheterization; D003326:Coronary Circulation / Q000502:physiology; D004285:Dogs; D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D066298:In Vitro Techniques; D011143:Polyvinyl Chloride / Q000378:metabolism; D011673:Pulsatile Flow / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology
chemical_list: D011143:Polyvinyl Chloride