title: Effects of some components of the essential oil of chamomile, Chamomilla recutita, on histamine release from rat mast cells.
abstract: The influence of three compounds of the essential oil of Chamomilla recutita (L.) Rauschert on the protamine sulphate-provoked degranulation of mast cells from Lewis-1a rats was investigated. The effect was determined by measuring histamine liberation fluorometrically. Chamazulene and (-)-alpha-bisabolol had no distinct effects. The en-yne dicycloether partly inhibited the degranulation in concentrations above 10(-4) M.
authors.affiliation: Institut für Pharmazeutische Biologie, Ernst-Moritz-Arndt Universität Greifswald, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Miller
authors.forename: U
authors.initials: U
authors.lastname: Wittstock
authors.forename: U
authors.initials: U
authors.lastname: Lindequist
authors.forename: E
authors.initials: E
authors.lastname: Teuscher
mesh_terms: D000818:Animals; D052176:Azulenes; D015550:Cell Degranulation; D003508:Cycloheptanes / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile / Q000737:chemistry*; D051381:Rats; D011917:Rats, Inbred Lew; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D052176:Azulenes; D003508:Cycloheptanes; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D012717:Sesquiterpenes; C004497:bisabolol; C013872:chamazulene