Autologous blood donation and epoetin alfa in cancer surgery.
Patients undergoing cancer surgery frequently require blood, and the transfusion of allogeneic blood in these patients has been controversially linked to an increased risk of tumor recurrence. This patient population may therefore benefit from preoperative autologous blood donation (ABD) with or without epoetin alfa therapy, although the precise impact of autologous blood transfusion has not been fully explored. In some trials, preoperative ABD reduced allogeneic blood exposure by 50% in patients undergoing surgery for cancer resection, while, in another study, perioperative treatment with epoetin alfa significantly increased hematocrit (Hct) levels preoperatively and led to a reduction in postoperative allogeneic blood exposure. A combination of epoetin alfa and preoperative ABD seems a reasonable approach to reducing allogeneic blood exposure in patients undergoing cancer surgery.
Jeekel
J
J
Department of Surgery, Erasmus University, Rotterdam, The Netherlands.
D000740:Anemia / Q000150:complications / Q000188:drug therapy; D001803:Blood Transfusion / Q000706:statistics & numerical data; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000706:statistics & numerical data; D015179:Colorectal Neoplasms / Q000097:blood / Q000401:mortality / Q000601:surgery; D018572:Disease-Free Survival; D000068817:Epoetin Alfa; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000601:surgery; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000601:surgery*; D011292:Premedication; D011446:Prospective Studies; D011994:Recombinant Proteins; D015996:Survival Rate; D065227:Transfusion Reaction; D016896:Treatment Outcome
D011994:Recombinant Proteins; D004921:Erythropoietin; D000068817:Epoetin Alfa