The influence of intracellular cAMP on T cell proliferation.
The role of AC-cAMP-PKA signal system in T cell activation was investigated by lymphocyte proliferation stimulated by anti-CD3 McAb. The results indicated that AC, cAMP and PKA play important roles in determining the responses of lymphocytes to the stimulation. Activation of AC and increase of intracellular cAMP could obviously decrease lymphocyte proliferation, and lymphocyte DNA synthesis was increased to some extent by the pretreatment of PKI.
Li
M
M
Department of Immunology, Tongji Medical University, Wuhan.
Yang
J
J
Hu
Y N
YN
Ye
X T
XT
Ye
W X
WX
D000262:Adenylyl Cyclases / Q000502:physiology; D002455:Cell Division; D000242:Cyclic AMP / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology*
D017260:Receptor-CD3 Complex, Antigen, T-Cell; D004247:DNA; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D000262:Adenylyl Cyclases