A therapeutic approach to erythrodermic psoriasis: report of a case and a discussion of therapeutic options.
In this case report a patient with therapeutically recalcitrant erythrodermic psoriasis is presented. After various attempts with several major therapies in this patient, the first substantial improvement was achieved using the combination of cyclosporine and calcipotriol, followed by the combination of UVB and calcipotriol. The therapeutic options for severe psoriasis are discussed, and since combined approaches seem to be an attractive alternative for severe psoriasis, mechanisms of synergy of combined therapeutic approaches are hypothesised.
van der Vleuten
C J
CJ
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Gerritsen
M J
MJ
Steijlen
P M
PM
de Jong
E M
EM
van de Kerkhof
P C
PC
D000368:Aged; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D003873:Dermatitis, Exfoliative / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D011565:Psoriasis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D014467:Ultraviolet Therapy
D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; C055085:calcipotriene; D016572:Cyclosporine; D002117:Calcitriol