[Immunohistochemical localization of Type I, II and IX collagens in pleomorphic adenoma of human salivary glands].
The expression patterns of type I, II and IX collagens in chondromyxoid tissue of salivary pleomorphic adenomas were examined by immunohistochemistry. In the early stage of cartilage development, type IX collagen was detected intracytoplasmically, mainly in the proliferating myoepithelial cells and not in the extracellular matrix. Proliferating myoepithelial cells did not show chondrocytic characteristics at this stage. Type I and II collagens were co-distributed in the extracellular matrix of myxoid tissue. In the chondroid tissue, variable immunostaining patterns of type I and II collagens were also observed. Some proliferating myoepithelial cells in myxoid and chondroid tissue were immunostained with anti-alpha-smooth muscle actin antibody indicating their myoepithelial origin. These results suggested that proliferating myoepithelial cells may be the origin of the chondroid tissue and the expression of type IX collagen in cartilaginous tissue precedes the expression of type I and II collagens.
Luna
M G
MG
Department of Oral Pathology, Tokyo Medical and Dental University, Japan.
D008949:Adenoma, Pleomorphic / Q000378:metabolism*; D000328:Adult; D000368:Aged; D002356:Cartilage / Q000254:growth & development / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000378:metabolism*
D003094:Collagen