Evaluation of the efficacy of albendazole against the larvae of Taenia solium in experimentally infected pigs, and kinetics of the immune response.
Cysticercosis, a disease of economic and public health importance, is caused by Cysticercus cellulosae, the metacestode stage of Taenia solium. Experimental induction of cysticercosis was achieved in young pigs by feeding an optimum dose of 20,000 T. solium (Indian strain) eggs after immunosuppression, to assess the effect of albendazole and development of the immune response to cysticercus antigens before and after treatment. Histopathological studies revealed the presence of cysticerei in liver, lungs and muscles. Treatment with albendazole at 15 mg kg-1 body weight daily for 30 days starting from day 0 or 15 days post-infection resulted in 100% cure rates. Increases in antibody titre to crude soluble extract and a Sephadek G-200 purified antigenic fraction of Cysticercus cellulosae were found on days 25, 40 and 55 post-infection in untreated pigs and those in which treatment started on day 15 post-infection, whereas no increase in antibody response was observed in pigs in which treatment started on day 0.
Kaur
M
M
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Joshi
K
K
Ganguly
N K
NK
Mahajan
R C
RC
Malla
N
N
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth; D003551:Cysticercosis / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D003552:Cysticercus / Q000187:drug effects* / Q000276:immunology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007700:Kinetics; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D013552:Swine
D000871:Anthelmintics; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015766:Albendazole