title: How is expression of the interleukin-5 gene regulated?
abstract: Eosinophilia is a uniquely specific phenomenon regulated by interleukin-5 (IL-5), suggesting specific control for IL-5 expression. However in eosinophilia IL-5 is often co-expressed with other lymphokines such as IL-4, indicating that common, as well as independent, control mechanisms must exist. IL-5 gene expression is regulated at the transcriptional level. The molecular analysis of the IL-5 promoter region reveals the presence of positive regulatory sites that are common to many lymphokine genes. Results from immunosuppression studies suggest that the key control mechanism of IL-5 regulation may not depend on specific regulatory factors but on how gene expression is activated.
authors.affiliation: TVW Telethon Institute for Child Health Research, Perth, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Karlen
authors.forename: V A
authors.initials: VA
authors.lastname: Mordvinov
authors.forename: C J
authors.initials: CJ
authors.lastname: Sanderson
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D015848:Interleukin-5 / Q000235:genetics*
chemical_list: D015848:Interleukin-5