title: Effects of 3-morpholinosydnonimine-N-ethylcarbamide on hypoxia-induced mechanical and electric responses of isolated pig coronary artery.
abstract: OBJECTIVE
  To study effects of 3-morpholinosydnonimine-N -ethylcarbamide (SIN-1) on hypoxia-induced mechanical and electric activities of the isolated pig coronary artery.
  
  
  METHODS
  Mechanical tension and membrane potential were measured simultaneously.
  
  
  RESULTS
  Hypoxia initially caused a transient vascular smooth muscle cell membrane hyperpolarization followed by a membrane depolarization in isolated pig coronary artery. Subsequent addition of SIN-1 100 mumol . L-1 or verapamil (Ver) 10 mumol . L-1 led to membrane repolarization and relaxation of the vascular smooth muscle. Nitro-L-arginine (NLA) 0.2 mmol . L-1 and KCI 40 mmol . L-1 also induced membrane depolarization and vasoconstriction, which were similarly suppressed by SIN-1 or Ver.
  
  
  CONCLUSIONS
  Hypoxic contractile response in isolated pig coronary artery is mediated by an increased Ca2+ influx via suppression of nitric oxide release.
authors.affiliation: Department of Pharmacology, Hebei Medical College, Shijiazhuang, China.
authors.forename: X P
authors.initials: XP
authors.lastname: Yang
authors.forename: F X
authors.initials: FX
authors.lastname: Wang
authors.forename: D C
authors.initials: DC
authors.lastname: Ren
authors.forename: S C
authors.initials: SC
authors.lastname: Lu
authors.forename: S X
authors.initials: SX
authors.lastname: Fu
authors.forename: Y S
authors.initials: YS
authors.lastname: Li
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D000860:Hypoxia / Q000503:physiopathology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D013552:Swine; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; C002385:linsidomine; D008981:Molsidomine