[Comparison of calcitonin tolerance after intramuscular or intranasal administration in treatment for postmenopausal osteoporosis].
The aim of the study was to compare the tolerance of synthetic salmon calcitonin applied in two different ways, intramuscularly or intranasally, in 50 patients with postmenopausal osteoporosis with bone fractures. Thirty patients were treated with calcitonin in intramuscular or subcutaneous injections, whereas in 20 cases calcitonin was applied in nasal spray. In the first group several side effects were observed, like nausea, vomiting, abdominal pains, skin rush, headaches, dropping blood pressure, symptoms of bronchial spasm. Finally in 13 cases it was necessary to stop calcitonin therapy. On the other hand the patients receiving calcitonin in nasal spray did not manifest any severe side effects.
Horst-Sikorska
W
W
Z Kliniki Endokrynologii, Akademii Medycznej w Poznaniu.
Ruszkowska
J
J
Kosowicz
J
J
D015746:Abdominal Pain / Q000139:chemically induced; D000281:Administration, Intranasal; D000368:Aged; D001986:Bronchial Spasm / Q000139:chemically induced; D002116:Calcitonin / Q000008:administration & dosage* / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D013610:Tachycardia / Q000139:chemically induced
D002116:Calcitonin
Porównanie tolerancji kalcytoniny podawanej domieśniowo lub donosowo w leczeniu osteoporozy pomenopauzainej.