title: (2E)-5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamic acid and its derivatives as novel and potent inhibitors of ras transformation.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohtani
authors.forename: T
authors.initials: T
authors.lastname: Matsuura
authors.forename: K
authors.initials: K
authors.lastname: Shirahase
authors.forename: K
authors.initials: K
authors.lastname: Sugita
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002461:Cell Line, Transformed / Q000187:drug effects / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000235:genetics*; D011905:Genes, ras; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010641:Phenotype; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: C100725:5-(3-((phenylsulfonyl)amino)phenyl)pent-2-en-4-ynohydroxamic acid; D006877:Hydroxamic Acids; D013449:Sulfonamides