Effect of (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide on spinal motor systems in anesthetized intact and spinalized rats.
In the present study, we examined the effect of the 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT), on the mono- and polysynaptic reflexes in intact and spinalized rats. 8-OH-DPAT (10 micrograms/kg i.v.) significantly potentiated the amplitude of the monosynaptic reflex in intact rats. In contrast, 8-OH-DPAT (30 and 100 micrograms/kg i.v.) produced a significant dose-related inhibition of the amplitude of the monosynaptic reflex in spinalized rats. These results suggest that 8-OH-DPAT predominantly excites spinal motor systems at the supraspinal site, and inhibits such systems at a spinal cord site.
Hasegawa
Y
Y
Department of Pharmacy, University of Tokyo, Japan. myutaka@ecc-mail.hongo.ecc.u-tokyo.ac.jp
Ono
H
H
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin