[Sodium ferulate alleviates prednisolone induced liver toxicity in mice].
Prednisolone (Pred) 20 mg.kg-1 sc caused an increase in serum glutamicpyruvic transaminase (sGPT) and serum glutathione S-transferase (sGST) activities and an elevation of MDA content in mouse liver homogenate. An increase of membrane fluidity of liver microsomes and mitochondria was also observed. The results indicate that the elevations of sGPT and sGST levels were related to enhancement of lipid peroxidation and membrane fluidity in Pred-treated mice. Pretreatment with sodium ferulate (SF) 100 mg.kg-1 partially alleviated the liver lesions as observed by electron microscope observation. The sGPT and sGST levels and liver homogenate MDA content were reduced, and the membrane fluidity of liver microsomes was recovered. But, the membrane fluidity of liver mitochondria was further elevated. The results demonstrate partial inhibitory effect of sodium ferulate on prednisolone-induced liver toxicity.
Wu
D F
DF
Department of Pharmacology, Hubei Medical University, Wuhan.
Peng
R X
RX
Wang
H
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D003373:Coumaric Acids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D011239:Prednisolone
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D011239:Prednisolone; C004999:ferulic acid; D005982:Glutathione Transferase; D000410:Alanine Transaminase