title: Topical treatment with 1% sodium cromoglycate in pyoderma gangrenosum.
abstract: BACKGROUND
  Pyoderma gangrenosum is an uncommon skin disease usually treated with systemic drugs, most frequently corticosteroids. Isolated topical treatment is usually considered unsatisfactory.
  
  
  OBJECTIVE
  To evaluate the effect of topical 1% sodium cromoglycate solution on pyoderma gangrenosum in 5 patients 25-30 years of age.
  
  
  METHODS
  5 patients, including 2 under systemic steroid treatment, hospitalized in our department from 1992 to 1993 because of pyoderma gangrenosum, were treated with topical 1% sodium cromoglycate solution. Systemic corticosteroids were further added in 2 patients whose initial improvement was inadequate.
  
  
  RESULTS
  Initial improvement was noted in all 5 patients after 3-7 days of sodium cromoglycate treatment. Complete healing of the ulcers occurred within 5-8 weeks.
  
  
  CONCLUSIONS
  Topical treatment with sodium cromoglycate can be effective as adjunctive or sole treatment in pyoderma gangrenosum.
authors.affiliation: Department of Dermatology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Tamir
authors.forename: M
authors.initials: M
authors.lastname: Landau
authors.forename: S
authors.initials: S
authors.lastname: Brenner
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D004205:Cromolyn Sodium