title: Incidence of leukaemia in young people around the La Hague nuclear waste reprocessing plant: a sensitivity analysis.
abstract: The objectives are to investigate the incidence of childhood leukaemia in young people around the French nuclear waste reprocessing plant (La Hague, Normandy) for the period 1978-1992, and to check the sensitivity of the results to the choice of disease clustering tests and reference rates. The performance of three statistical procedures are compared: a conventional approach; a Poisson maximum test, and an extraction mapping technique. On the whole, the results are in general agreement and demonstrate the apparent existence of a distinct cluster of childhood leukaemia, contiguous and south-east of the La Hague nuclear facility.
authors.affiliation: Department of Public Health, Biostatistics and Epidemiology, Besançon, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Viel
authors.forename: D
authors.initials: D
authors.lastname: Pobel
authors.forename: A
authors.initials: A
authors.lastname: Carré
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology*; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology; D016013:Likelihood Functions; D015233:Models, Statistical; D016012:Poisson Distribution; D011850:Radioactive Waste / Q000009:adverse effects*; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D011850:Radioactive Waste