[Investigation of the impurity profile of nifedipine by LC/MS].
The manufacture-characteristic impurity profile of nifedipine drug substance was studied by HPLC and on-line LC/MS coupling. Using a new gradient HPLC procedure and MS detection, spectroscopic evidences for the chemical structure of some previously unknown minor impurities (all under 0.1%) were obtained.
Karancsi
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Karaffa
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Ladányi
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D002851:Chromatography, High Pressure Liquid / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D009543:Nifedipine / Q000737:chemistry / Q000302:isolation & purification / Q000592:standards*
D009543:Nifedipine
A nifedipin hatóanyag szennyezésprofiljának LC/MS vizsgálata.