title: Anticholesterol antibodies and plaque formation.
abstract: Immunization of rabbits with a protein-free formulation consisting of liposomes containing 71% cholesterol and lipid A induced cholesterol antibodies in rabbits fed a diet containing 0.5% and 1.0% cholesterol. Elevation in plasma cholesterol levels was significantly less in immunized than in nonimmunized rabbits. Immunization also resulted in a marked decrease in the risk of developing atherosclerosis as determined by analysis of aortic atherosclerosis by quantitative histological examination and fatty streaks by automated morphometric probability-of-occurrence mapping.
authors.affiliation: Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center at Tufts University, Boston, MA 02111, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Ordovas
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000276:immunology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D006801:Humans; D007114:Immunization; D011817:Rabbits
chemical_list: D002791:Cholesterol, Dietary; D002784:Cholesterol