[The effect of the joint administration of heparin and chitosan sulfate ether on hemostatic function].
We studied anticoagulant effects of combined administration of heparin (H) and chitosan sulfate ether (CS) (specific activity 20 UE/mg) in the ratio 1 : 1. CS enhanced anticoagulant activity of heparin in rabbits by a factor of 1.95 +/- 0.15. The intravenous injection of the mixture in a dose of 0.5 mg(H)/kg + 0.5 mg(CS)/kg and heparin injection in a dose of 1mg/kg induced the same effect. Haemorrhagic effect of this mixture was less pronounced compared to heparin, anticoagulant and antithrombotic activities remained the same. The mixture was found to decrease a number of platelets, however, this was also less pronounced compared to heparin. Thus, the use of the mixture CS + H (1 : 1) instead of double heparin dose resulted in the same effect.
Drozd
N N
NN
Makarov
V A
VA
Bashkov
G V
GV
Gal'braĭkh
L S
LS
Vikhoreva
G A
GA
Gorbacheva
I N
IN
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced; D006487:Hemostasis / Q000187:drug effects*; D006490:Hemostatics / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D051381:Rats; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D000925:Anticoagulants; D006490:Hemostatics; D002686:Chitin; D006493:Heparin; D048271:Chitosan
Vliianie sovmestnogo vvedeniia geparina i sernokislogo éfira khitozana na funktsiiu gemostaza.