Changes in the ratio of urinary alpha 1-microglobulin to ulinastatin levels in patients with Alzheimer-type dementia and vascular dementia.
Relationships between urinary levels of alpha 1-microglobulin (alpha 1M) and ulinastatin (UT) in patients with dementia were investigated. There were no significant differences in alpha 1M and UT levels and alpha 1M: UT ratios among three groups: age-matched control subjects, patients with either Alzheimer-type senile dementia (ATD) or vascular dementia (VD). Although a positive correlation was established between alpha 1M and UT levels in these groups, the regression of the demented patients differed significantly from that of controls (P < 0.05). A tendency towards a negative correlation between alpha 1M: UT ratios and the levels of severity or duration of the disease was displayed in the ATD group, whereas a tendency toward a positive correlation between alpha 1M: UT ratios and the levels of severity was observed in the VD group. These results suggest that changes in the relationships between urinary levels of alpha 1M and UT may provide a useful biochemical index for diagnoses of ATD and VD.
Inagaki
T
T
Department of Psychiatry, Shimane Medical University, Izumo, Japan.
Shikimi
T
T
Ishino
H
H
Okunishi
H
H
Takaori
S
S
D000368:Aged; D000369:Aged, 80 and over; D000510:Alpha-Globulins / Q000652:urine*; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology / Q000652:urine; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000523:psychology / Q000652:urine; D003937:Diagnosis, Differential; D005260:Female; D006023:Glycoproteins / Q000652:urine*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012016:Reference Values
D000510:Alpha-Globulins; D006023:Glycoproteins; C016001:alpha-1-microglobulin; C028665:urinastatin