Hypertonic hemolysis in patients with a mood disorder.
Hypertonic hemolysis was increased in patients with a manic episode (n = 6, mean NaCl concentration in mol/L at which 50% of the erythrocytes was hemolyzed (H50) 3.24 +/- 0.10), compared to healthy controls (n = 12, mean H50 3.43 +/- 0.13) (p < or = 0.02) and patients with a nonaffective psychotic disorder (n = 15, mean H50 3.42 +/- 0.18) (p < or = 0.02). Compared to these two control groups, hypertonic hemolysis was decreased in patients with a severe depressive episode (n = 8, mean H50 3.62 +/- 0.19) (p < or = 0.05 and p < or = 0.02, respectively). Within the total depressed patient group, the patients with an increased genetic vulnerability (n = 8, mean H50 3.68 +/- 0.16) showed a decreased hypertonic hemolysis compared to the other depressed patients (n = 14, mean H50 3.40 +/- 0.16) (p < or = 0.002).
Hoeksema
T
T
Department of Psychiatry, University of Leiden, The Netherlands.
Goekoop
J G
JG
Van Kempen
G M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood* / Q000235:genetics; D003866:Depressive Disorder / Q000097:blood* / Q000235:genetics; D005260:Female; D006461:Hemolysis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009996:Osmotic Fragility / Q000235:genetics / Q000502:physiology*; D012307:Risk Factors