Lujan-Fryns syndrome in the differential diagnosis of schizophrenia.
Schizophrenia is considered to be a heterogenous disorder. Different etiopathological mechanism can be attributed to a similar clinical picture as described in DSM-III-R criteria. We present a case of a young man diagnosed on different occasions as schizophrenic with mild mental retardation. Clinical examination revealed signs and symptoms most compatible with the diagnosis of Lujan-Fryns syndrome, an X-linked mental retardation syndrome with marfanoid features, frequently associated with psychotic or other psychiatric symptoms. In all patients with symptoms of schizophrenia and mental retardation Lujan-Fryns syndrome should be considered in the differential diagnosis.
De Hert
M
M
University Psychiatric Center St. Jozef, Kortenberg, Belgium.
Steemans
D
D
Theys
P
P
Fryns
J P
JP
Peuskens
J
J
D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D003937:Diagnosis, Differential; D005145:Face / Q000002:abnormalities; D006228:Hand Deformities, Congenital; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis* / Q000523:psychology; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis*; D013577:Syndrome