title: Interposition vein cuffs.
abstract: A vein cuff interposed at the distal anastomosis between a prosthetic vascular graft and a recipient infrageniculate artery improves the chances of continued patency of the graft, at least in the short and medium term. The mode of effect appears to be suppression or modification of anastomotic myointimal hyperplasia (MIH). In the event of graft failure the recipient artery and run-off vessels remain free from MIH and their patency is preserved thereby improving the prospects for further vascular reconstruction and limb salvage. The mechanisms by which interposition vein cuffs might modulate MIH are reviewed. Experimental evidence is described to show that the geometry of a cuffed anastomosis promotes a characteristic haemodynamic flow structure with a stable vortex. It is suggested that this vortex exerts greater shear stress upon the wall of the artery than the normal laminar flow observed in conventional anastomoses. High shear stress is known to inhibit MIH.
authors.affiliation: Department of Vascular Surgery, Royal Liverpool University Hospital, England.
authors.forename: P
authors.initials: P
authors.lastname: Harris
authors.forename: T
authors.initials: T
authors.lastname: Da Silva
authors.forename: T
authors.initials: T
authors.lastname: How
mesh_terms: D000714:Anastomosis, Surgical; D001807:Blood Vessel Prosthesis / Q000379:methods*; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D012501:Saphenous Vein / Q000637:transplantation*; D013536:Suture Techniques
chemical_list: D011138:Polytetrafluoroethylene