Effect of thyrotropin-releasing hormone on Na(+)-K(+)-Adenosine triphosphatase activity following experimental spinal cord trauma.
The effect of thyrotropin-releasing hormone (TRH) on spinal cord Na(+)-K(+-adenosine triphosphatase (Na+-K+-ATPase) activity after spinal cord injury was evaluated in rats. The rats were injured by compression of the cord at T-10 for 1 minute with a 50-g clip. Saline in the placebo group (n = 8) and TRH (0.6 mg per dose) in the TRH group (n = 9) were administered intraperitoneally as bolus injections in two doses, at 45 and 120 minutes after the injury. The Na(+)-K(+)-ATPase activity level in the TRH group was significantly higher (p = 0.024) than in placebo group. These results indicate a possible role for TRH treatment in spinal cord injury.
Baykal
S
S
Department of Neurosurgery, Black Sea Technical University, Trabzon, Turkey.
Ceylan
S
S
Usul
H
H
Aktürk
F
F
Değer
O
O
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D046508:Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects*; D013119:Spinal Cord Injuries / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D000251:Adenosine Triphosphatases