title: Effect of craniectomy/durotomy alone and in combination with hyperventilation, diuretics, and corticosteroids on intracranial pressure in clinically normal dogs.
abstract: OBJECTIVE
  To determine the effect of craniectomy and durotomy on intracranial pressure (ICP) in clinically normal dogs.
  
  
  METHODS
  Two-part study (experiments A and B) involving craniectomy and durotomy, with and without treatments to lower ICP.
  
  
  METHODS
  Six (experiment A) and 7 (experiment B) healthy dogs.
  
  
  METHODS
  In experiment A, craniectomy was performed in combination with durotomy, diuretic administration, methylprednisolone sodium succinate administration, and hyperventilation, and effect of these manipulations on ICP was determined. In experiment B, dogs had only craniectomy and durotomy without associated ICP-lowering treatments. During both experiments, ICP was monitored throughout the surgical procedure with a fiber optic ICP monitoring device.
  
  
  RESULTS
  Intracranial pressure decreased after the combination of craniectomy, durotomy, and other ICP-lowering treatments in dogs of experiment A. Similar magnitude of decrease in ICP was observed in dogs of experiment B after craniectomy and durotomy.
  
  
  CONCLUSIONS
  Comparison of these experiments indicate that surgical removal of overlying skull and incision of the dura mater can significantly decrease ICP in clinically normal dogs.
  
  
  CONCLUSIONS
  Craniectomy and durotomy may be useful as an adjunct treatment for increased ICP.
authors.affiliation: Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164-6610, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Bagley
authors.forename: M L
authors.initials: ML
authors.lastname: Harrington
authors.forename: G E
authors.initials: GE
authors.lastname: Pluhar
authors.forename: R D
authors.initials: RD
authors.lastname: Keegan
authors.forename: S A
authors.initials: SA
authors.lastname: Greene
authors.forename: M P
authors.initials: MP
authors.lastname: Moore
authors.forename: P R
authors.initials: PR
authors.lastname: Gavin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects; D003399:Craniotomy / Q000379:methods / Q000662:veterinary*; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004388:Dura Mater / Q000502:physiology* / Q000601:surgery; D005665:Furosemide / Q000494:pharmacology*; D006985:Hyperventilation / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000187:drug effects / Q000502:physiology*; D008775:Methylprednisolone / Q000494:pharmacology*; D012016:Reference Values
chemical_list: D000305:Adrenal Cortex Hormones; D004232:Diuretics; D005665:Furosemide; D008775:Methylprednisolone