title: [Prospective study on intelligence quotient of 28 hepatic lenticular degeneration patients with treatment combining traditional Chinese and Western medicine].
abstract: Intelligence quotient (IQ) of 28 hepatic lenticular degeneration (HLD) patients was analysed with Wechsler Adult Intelligence Scale-revised by China (WAIS-RC) before and after two months treatment by the HLD-Relief decoction supplemented with copper-clearing drug, and the result was compared with that of 30 healthy persons for control. The results showed that the Vocable IQ (VIQ), Performance IQ(PIQ) and Full IQ(FIQ) of HLD patients were markedly lower than that of control (P < 0.005), especially in visual space disorder, which indicated that the copper ion depositing in patient's brain not only damaged neuronic motorial functions but also produced a marked effect on the patient's intelligence. After treatment, the total intelligential level including VIQ, PIQ and FIQ has been raised, particularly in PIQ in which all scores were obviously increased (P < 0.001). It was also showed that the damage of intelligence in HLD patient became more serious as the course of disease was prolonged and the early treatment facilitated the IQ level to approach the normal criterion. It indicated that the treatment with combined therapy is effective to the intelligence and extrapyramidal symptoms in HLD patients.
authors.affiliation: Institute of Neurology, Anhui College of TCM, Hefei.
authors.forename: Y L
authors.initials: YL
authors.lastname: Cai
authors.forename: R M
authors.initials: RM
authors.lastname: Yang
authors.forename: S H
authors.initials: SH
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D002614:Chelating Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage; D011446:Prospective Studies; D004113:Succimer / Q000008:administration & dosage*; D014888:Wechsler Scales
chemical_list: D002614:Chelating Agents; D004365:Drugs, Chinese Herbal; D004113:Succimer; D010396:Penicillamine