Abnormal modulation of cholinergic neurotransmission by opioid in hyperresponsive bronchus of rats.
1. The electrical field stimulation (EFS)-induced bronchoconstriction in vitro in rats challenged by DNP-Ascaris antigen was significantly greater than that in normal rats. 2. Morphine inhibited the EFS-induced bronchoconstriction in normal rats. Whereas the inhibition of EFS-induced bronchoconstriction by the opioid was little, if any, in the DNP-Ascaris-challenged rats. 3. These findings suggest that dysfunction of presynaptic inhibitory modulation through the opioid receptor may take place in the airways of DNP-Ascaris-challenged rats.
Misawa
M
M
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Sato
J
J
Furukawa
Y
Y
Chiba
Y
Y
Hosokawa
T
T
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001200:Ascaris / Q000276:immunology; D001980:Bronchi / Q000294:innervation / Q000378:metabolism; D016535:Bronchial Hyperreactivity / Q000378:metabolism / Q000503:physiopathology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009294:Narcotics / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects*
D009294:Narcotics; D009020:Morphine; D000109:Acetylcholine