Growth hormone deficiency and hypogonadism in a patient with multiple sclerosis.
We describe the case of a 30-year-old female patient with a 7-year history of multiple sclerosis, who presented with an 18-month history of secondary amenorrhoea and vague symptoms which included poor sleep and impaired concentration. Endocrine investigations revealed hypogonadotrophic hypogonadism and GH deficiency, a probable consequence of a hypothalamic plaque. This is the first report of hypogonadotrophic hypogonadism and GH deficiency occurring in conjunction with multiple sclerosis. As such, it should raise suspicion of endocrine dysfunction occurring in a condition with such a vast spectrum of disability as multiple sclerosis.
Davies
J S
JS
Department of Medicine, University of Wales College of Medicine, Cardiff.
Hinds
N P
NP
Scanlon
M F
MF
D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D009103:Multiple Sclerosis / Q000150:complications*
D013006:Growth Hormone