title: BCR/ABL and leukemia.
abstract: This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of possible therapeutic implications of these data.
authors.affiliation: Department of Pediatrics, University of Parma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Butturini
authors.forename: R B
authors.initials: RB
authors.lastname: Arlinghaus
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
mesh_terms: D000818:Animals; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*
chemical_list: D016044:Fusion Proteins, bcr-abl