Formulation and in vitro examination of furosemide containing suppositories and preliminary experiences of their clinical use.
Rectal suppositories containing furosemide (4-chloro-N-furfuryl-5-sulfamoylanthranilic acid) and furosemide sodium were formulated with various suppository bases. The in vitro drug release of Massa Estarinum 299 proved to be the best from the vehicle having various physical-chemical properties. The diuretic effect of the two suppositories was compared in a prospective, crossover clinical trial including 8 patients. Both preparations have induced an increase of urine flow, which was comparable to the diuretic effect of the tablet.
Regdon
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Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Fazekas
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Regdon
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Selmeczi
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B
D001682:Biological Availability; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018592:Cross-Over Studies; D004232:Diuretics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004311:Double-Blind Method; D005079:Excipients; D005665:Furosemide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D011446:Prospective Studies; D013488:Suppositories; D013810:Therapeutic Equivalency; D014563:Urodynamics / Q000187:drug effects
D004232:Diuretics; D005079:Excipients; D013488:Suppositories; D005665:Furosemide