title: The molecular biology of SRY and its role in sex determination in mammals.
abstract: SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.
authors.affiliation: Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Koopman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005314:Embryonic and Fetal Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008322:Mammals / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012732:Sex Determination Analysis / Q000379:methods*; D013737:Testis / Q000196:embryology*
chemical_list: D006609:High Mobility Group Proteins