title: Dental considerations for a Glanzmann's thrombasthenia patient: case report.
abstract: Glanzmann's thrombasthenia is a qualitative platelet disorder characterized by a deficiency in the platelet membrane glycoproteins (GP) IIb-IIIa. It belongs to a group of hereditary platelet disorders typified by normal platelet numbers and a prolonged bleeding time. The bleeding seen in Glanzmann's thrombasthenia usually includes bruising, epistaxis, gingival hemorrhage, and menorrhagia. Spontaneous, unprovoked bleeding is unusual. The severity of bleeding is unpredictable in thrombasthenia and does not correlate with the severity of the platelet GP IIb-IIIa abnormality. The present case report describes the dental treatment of a patient with Glanzmann's thrombasthenia. A 39-year-old female with a history of Glanzmann's thrombasthenia presented for periodontal therapy for spontaneous gingival hemorrhage. The patient had been sporadically seen in the past and had a record of only returning for appointments on an "emergency" basis. The periodontal findings revealed a diagnosis of moderate to advanced adult periodontitis in all quadrants. After all dental options had been discussed, the treatment of choice was determined to be extraction of the remaining dentition and fabrication of immediate dentures. The patient received a loading dose of 5 grams of aminocaproic acid (EACA) intravenously 3 hours prior to the surgery. At the beginning of the extractions 1 gram of EACA per hour continuous infusion and a 6 pack of platelets was administered. The patient tolerated the extractions well. All sites healed normally. The patient has had no difficulty in adjusting to the dentures. The case report discusses a possible treatment option in a noncompliant patient having Glanzmann's thrombasthenia and briefly discusses other hereditary bleeding disorders with similar presentations.
authors.affiliation: U.S. Army Dental Activity, Ft. Gordon, GA, USA.
authors.forename: F C
authors.initials: FC
authors.lastname: Bisch
authors.forename: K J
authors.initials: KJ
authors.lastname: Bowen
authors.forename: B S
authors.initials: BS
authors.lastname: Hanson
authors.forename: V L
authors.initials: VL
authors.lastname: Kudryk
authors.forename: M A
authors.initials: MA
authors.lastname: Billman
mesh_terms: D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use; D017742:Dental Care for Chronically Ill / Q000379:methods*; D005260:Female; D005884:Gingival Hemorrhage / Q000209:etiology* / Q000601:surgery; D006801:Humans; D017713:Platelet Transfusion; D011300:Preoperative Care; D013915:Thrombasthenia / Q000150:complications* / Q000601:surgery; D014081:Tooth Extraction
chemical_list: D000614:Aminocaproates