title: Ovariectomy decreases osteogenetic activity in rat bone.
abstract: The purpose of this study was to investigate the effect of ovariectomy on osteoinductive activity in the bone in rat. Homograft implantation of decalcified humeral diaphysis from ovariectomized or sham-operated rats was performed and harvested after several time periods. A significant decrease in bone induction was found in terms of soft X-ray photography, alkaline phosphatase activity, mineral content and expression of osteocalcin (BGP; bone gla-protein) in the implants from the ovariectomized group in comparison to those from the sham-operated animals. This result suggested that the level of osteoinductive activity, probably due to bone morphogenetic protein, decreased in ovariectomized animals.
authors.affiliation: Department of Biochemistry, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
authors.forename: M S
authors.initials: MS
authors.lastname: Goseki
authors.forename: N
authors.initials: N
authors.lastname: Omi
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Oida
authors.forename: I
authors.initials: I
authors.lastname: Ezawa
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D015519:Bone Density; D016025:Bone Transplantation; D001842:Bone and Bones / Q000737:chemistry / Q000378:metabolism; D002118:Calcium / Q000032:analysis; D005260:Female; D015870:Gene Expression; D007700:Kinetics; D015675:Osteocalcin / Q000235:genetics; D010012:Osteogenesis / Q000502:physiology*; D010052:Ovariectomy; D010758:Phosphorus / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011506:Proteins; D012333:RNA, Messenger; D015675:Osteocalcin; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium