Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica.
Two novel cyclic peptides were isolated from the latex of Jatropha podagrica, which we named podacycline A and B. Podacycline A is a cyclic nonapeptide with the sequence Gly1-Leu2-Leu3-Gly4-Ala5-Val6-Trp7-Ala8-Gly9+ ++-Gly1. The sequence of podacycline B, a cyclic heptapeptide, was determined to be Phe1-Ala2-Gly3-Thr4-Ile5-Phe6-Gly7-Phe1. The amino acid residues of both compounds were found to have the L-configuration.
Van den Berg
A J
AJ
Department of Pharmacognosy, Universiteit Utrecht, Netherlands.
Horsten
S F
SF
Kettenes-van den Bosch
J J
JJ
Beukelman
C J
CJ
Kroes
B H
BH
Leeflang
B R
BR
Labadie
R P
RP
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D002852:Chromatography, Ion Exchange; D007840:Latex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000596:Amino Acids; D007840:Latex; D010456:Peptides, Cyclic; C101842:podacycline A; C101843:podacycline B