Combinations of ganciclovir and antibody for experimental CMV infections.
The effect of combined treatment with ganciclovir and hyper immune serum (HIS) was evaluated in three animal models. It concerned a generalized CMV infection model, a meningo-encephalitis model and an interstitial lung disease (ILD) model in immunocompromised rats. In the generalized model, the ganciclovir and HIS had a moderate synergistic effect on survival and greatly decreased virus titers in internal organs. In contrast, in the meningoencephalitis model, combined treatment had no effect on the local virus titers and the histopathology. Combined treatment with ganciclovir and HIS, however, effectively abolished CMV-induced ILD.
Stals
F S
FS
Department of Medical Microbiology, University of Limburg, Maastricht, The Netherlands.
Wagenaar
S S
SS
Kloover
J S
JS
Vanagt
W Y
WY
Bruggeman
C A
CA
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D007106:Immune Sera / Q000008:administration & dosage*; D016867:Immunocompromised Host; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000821:virology; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy / Q000821:virology; D051381:Rats; D011914:Rats, Inbred BN
D000914:Antibodies, Viral; D007106:Immune Sera; D015774:Ganciclovir