title: Periarticular ankle sarcoidosis: a variant of Löfgren's syndrome.
abstract: OBJECTIVE
  To focus more attention on the syndrome characterized by periarticular ankle inflammation associated with bilateral hilar adenopathy--some authors regard it as a variant of the Löfgren syndrome, while other suggest it is a distinct clinical entity-- we present a series of 33 cases of periarticular ankle sarcoidosis.
  
  
  METHODS
  Sarcoidosis was diagnosed in 330 patients at Bellvitge Hospital over a 20 year period. The medical charts of patients who presented with periarticular ankle inflammation (swelling of both ankles with acute inflammatory signs and preserved articular motion) were reviewed.
  
  
  RESULTS
  33 patients (10%) were identified. Periarticular ankle inflammation began during the spring in more than one-half (54.5%). The mean age was 33 years and patients were predominantly women (66.6%). Most cases (78.8%) were stage I on chest radiograph. All patients had thoracic gallium scans showing increased hilar/mediastinal uptake. Increased characteristic parotid, lacrimal, and/or submandibular uptake was found in 11 of 13 patients who had head scans. Four of 6 whose scans included the legs had bilateral ankle uptake. Erythema nodosum was present concomitantly in 36.3% of patients. No granulomas were found in 4 biopsies of periarticular ankle tissue. All 24 patients who were followed had inactive disease one year after diagnosis.
  
  
  CONCLUSIONS
  The association of periarticular ankle inflammation with bilateral hilar adenopathy is an acute form of sarcoidosis that follows a benign course to total remission. It should be regarded as a variant of the Löfgren syndrome.
authors.affiliation: Internal Medicine Service, Ciutat Sanitària i Universitària de Bellvitge, University of Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Mañá
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Vaquero
authors.forename: A
authors.initials: A
authors.lastname: Salazar
authors.forename: J
authors.initials: J
authors.lastname: Valverde
authors.forename: X
authors.initials: X
authors.lastname: Juanola
authors.forename: R
authors.initials: R
authors.lastname: Pujol
mesh_terms: D000328:Adult; D000368:Aged; D000843:Ankle Joint; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D013902:Radiography, Thoracic; D012507:Sarcoidosis / Q000175:diagnosis*; D013577:Syndrome
chemical_list: D005710:Gallium Radioisotopes