Dopamine receptors--the present state of research and perspectives.
The aim of the review is a brief description of the present status of research and perspectives in the field of multiple dopamine receptors, as well as of the importance of new discoveries for the treatment of schizophrenic psychoses and Parkinson's disease. Since the discovery of D1 and D2 dopamine receptors in the seventhies, evidence has accumulated for the existence of some new dopamine receptors. Among them the D3, D4 and D5 receptors, as well as their isoforms have been cloned. Molecular biology and pharmacology of these receptors have been exhaustively studied in recent years. These studies have prompted a number of hypotheses which open new perspectives for investigation into pathophysiology and therapy of schizophrenia and Parkinson's disease.
Wolfarth
S
S
Department of Neuro-Psychopharmacology, Polish Academy of Sciences, Kraków, Poland.
Ossowska
K
K
D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019204:GTP-Binding Proteins / Q000145:classification; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy*; D011954:Receptors, Dopamine / Q000737:chemistry*; D017447:Receptors, Dopamine D1 / Q000032:analysis; D017448:Receptors, Dopamine D2 / Q000032:analysis; D012106:Research; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology
D000978:Antiparkinson Agents; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019204:GTP-Binding Proteins