title: Confirmation of linkage of Sjögren-Larsson syndrome to chromosome 17 in families of different ethnic origins.
abstract: Linkage analysis in two consanguineous pedigrees of Pakistani and English origin and one further Indian family in which affected subjects have Sjögren-Larsson syndrome (SLS) showed linkage to chromosome 17. Linkage of SLS to D17S783 and D17S805 has been reported in Swedish pedigrees, but since those data were generated from a single ethnic group originating from a common ancestor, there remained the question of whether this disease is genetically heterogeneous. This report confirms the linkage in non-Swedish pedigrees and, therefore, provides evidence to support a single locus for SLS.
authors.affiliation: Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Lacour
authors.forename: H R
authors.initials: HR
authors.lastname: Middleton-Price
authors.forename: J I
authors.initials: JI
authors.lastname: Harper
mesh_terms: D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004739:England; D005006:Ethnicity; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010154:Pakistan; D010375:Pedigree; D016111:Sjogren-Larsson Syndrome / Q000235:genetics*; D013548:Sweden
chemical_list: D005819:Genetic Markers