title: Acute infarction of the left ventricular papillary muscle: electrocardiographic pattern and recognition of its location.
abstract: OBJECTIVE
  ST-segment depression during acute myocardial infarction (AMI) is known to herald serious hemodynamic complications. Since the mechanism of this dependence is not clear, we reinvestigated the old concept of papillary muscle infarction (PMI) as a cause of marked ST depression.
  
  
  METHODS
  Autopsies and morpho-electrocardiographic cor-relations were performed in 53 patients with AMI involving one or both left ventricular papillary muscles, and in 10 patients with AMI, but without acute PMI.
  
  
  RESULTS
  ST-segment depression > or = 1 mm in at least two leads (mean 3.6 +/- 2.2 mm) was found in 46 (86.8%) patients with, and in one without acute PMI. Thus, the sensitivity and specificity in selecting patients with acute PMI from among those with AMI were 86.8 and 90%, respectively, with an overall accuracy of diagnosis of acute PMI in the course of AMI of 87.3%. Among 26 patients with ST elevation consistent with diagnosis of AMI, ST depression, recorded in 22 patients, was insignificantly greater than in 24 of 27 patients without ST elevation: 4.1 +/- 2.9 versus 3.1 +/- 1.2 mm. Localization of ST depression in the limb leads allowed recognition of which papillary muscle suffered from acute infarction: ST depression in the inferior leads was seen only in patients with anterolateral PMI, whereas in leads I and/or a VL it was seen only in cases with posteromedial PMI. This rule was also valid in patients without concomitant ST elevation.
  
  
  CONCLUSIONS
  Patients with acute PMI show marked ST-segment depression. Its location in the limb leads allows recognition of which papillary muscle has undergone necrosis. This cause of marked ST depression in patients with AMI may explain the high mortality in this particular group.
authors.affiliation: Department of Hypertension and Angiology, First Medical Faculty, Warsaw Academy of Medicine, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Dabrowska
authors.forename: E
authors.initials: E
authors.lastname: Walczak
authors.forename: R
authors.initials: R
authors.lastname: Prejs
authors.forename: M
authors.initials: M
authors.lastname: Zdzienicki
mesh_terms: D000368:Aged; D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D010210:Papillary Muscles / Q000473:pathology / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology*