Transient acute monoblastic leukemia with reciprocal (8;16)(p11;p13) translocation.
The translocation of t(8;16)(p11;p13) has been demonstrated in the blasts of a phenotypically normal newborn baby with acute monoblastic leukemia. No antileukemic therapy was administered and spontaneous, complete remission was observed at 2 months of age. The patient remains well 18 months after the diagnosis and continues to have a normal hemogram.
Sainati
L
L
Department of Pediatrics, Padua University, Italy.
Bolcato
S
S
Cocito
M G
MG
Zanesco
L
L
Basso
G
G
Montaldi
A
A
Piovesan
A L
AL
D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D012075:Remission, Spontaneous; D013997:Time Factors; D014178:Translocation, Genetic