title: Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment.
abstract: Peripheral blood leukocytes interact with the vascular endothelium in a wide range of physiologic and pathophysiologic situations. A current working concept is that activation of vascular endothelium is an important event during the inflammatory response, conferring spatial and temporal localization and leukocyte-type selectivity to the recruitment process. This chapter highlights recent advances in our understanding of the endothelial-dependent molecular mechanisms that mediate recruitment of mononuclear leukocytes (lymphocytes and monocytes) and discusses these advances in the context of chronic inflammatory diseases and their potential therapeutic interventions.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: F W
authors.initials: FW
authors.lastname: Luscinskas
authors.forename: M A
authors.initials: MA
authors.lastname: Gimbrone
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D007964:Leukocytosis / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology
chemical_list: D015815:Cell Adhesion Molecules