title: An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia.
abstract: Mismatch negativity (MMN) and P300 to auditory stimuli was carried out using global field power (GFP) in 25 schizophrenics and 25 normal controls. The peak latencies of MMN and P300 were significantly longer in schizophrenics than in normal controls, and the differences in MMN were marked in the frontal regions. The peak amplitudes of MMN and P300 were significantly smaller in schizophrenics. The scalp distribution of MMN to 1050 Hz tone differed between the two groups, although that to 1100 Hz was similar to each other. The results indicate an impairment in the automatic discrimination process of auditory input in schizophrenics.
authors.affiliation: Department of Neuropsychiatry, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shutara
authors.forename: Y
authors.initials: Y
authors.lastname: Koga
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Mochida
authors.forename: K
authors.initials: K
authors.lastname: Takemasa
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*