title: Apolipoprotein E genotype and Alzheimer's disease in an elderly Norwegian cohort.
abstract: Apolipoprotein E (Apo E) genotyping was performed on an autopsy cohort of neuropathologically verified non-demented controls and subjects with Alzheimer's disease (AD) resident in nursing homes in the Oslo area. AD was associated with a significantly increased frequency of the Apo E epsilon 4 allele; the frequency of the epsilon 2 and epsilon 3 alleles was lower in AD but not significantly so. Age at death in the control group and the AD group did not differ significantly; neither did age at death nor age at onset of dementia in AD vary according to Apo E genotype, though tendencies towards an earlier age at death was seen in individuals with epsilon 4/4 and earlier age at onset dementia in the presence of an epsilon 4 allele and a later age of onset the presence of an epsilon 3 allele were seen. Possession of an epsilon 2 allele had no effect on age at onset of dementia or age at death. Among the possible genotypes there was a trend towards a progression of earliest onset epsilon 4/4, epsilon 2/4, epsilon 3/4, epsilon 3/3, epsilon 2/3 latest onset of dementia and longest duration epsilon 2/4, epsilon 4/4, epsilon 3/4, epsilon 3/3, epsilon 2/3 to shortest duration of dementia.
authors.affiliation: MRC Neurochemical Pathology Unit, Newcastle General Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Benjamin
authors.forename: A
authors.initials: A
authors.lastname: Leake
authors.forename: F K
authors.initials: FK
authors.lastname: McArthur
authors.forename: J M
authors.initials: JM
authors.lastname: Candy
authors.forename: P G
authors.initials: PG
authors.lastname: Ince
authors.forename: J A
authors.initials: JA
authors.lastname: Edwardson
authors.forename: A
authors.initials: A
authors.lastname: Torvik
authors.forename: C M
authors.initials: CM
authors.lastname: Morris
authors.forename: E
authors.initials: E
authors.lastname: Bjertness
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D005838:Genotype; D006801:Humans; D009664:Norway; D009778:Occipital Lobe / Q000378:metabolism; D016133:Polymerase Chain Reaction
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; C049578:apolipoprotein E5