Antagonistic effect of oral bacteria towards Treponema denticola.
This study was designed to isolate oral bacteria exhibiting antagonism towards Treponema denticola and to characterize the inhibitory activity. Eleven bacterial isolates obtained from subgingival sites and identified as either Staphylococcus aureus or Streptococcus mutans were found to inhibit the growth of T. denticola. When the activity spectra of these isolates were analyzed, two additional periodontopathogens (Porphyromonas gingivalis and Prevotella intermedia) were found to be affected, whereas most gram-positive bacteria were not. Strains of S. aureus produce a bacteriocin-like inhibitory substance (heat stable and protease sensitive), whereas the inhibitory effect of S. mutans appears to be related to the production of lactic acid. The negative interactions reported in this paper may govern population shifts observed in subgingival sites.
Grenier
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Groupe de Recherche en Ecologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec, Canada. Daniel.Grenier@greb.ulaval.ca
D001419:Bacteria / Q000302:isolation & purification; D018407:Bacterial Physiological Phenomena; D001430:Bacteriocins / Q000096:biosynthesis; D017753:Ecosystem; D006094:Gram-Positive Bacteria / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D009055:Mouth / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology; D018720:Prevotella / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000502:physiology; D013295:Streptococcus mutans / Q000302:isolation & purification / Q000502:physiology; D014208:Treponema / Q000254:growth & development* / Q000472:pathogenicity
D001430:Bacteriocins; D007773:Lactates; D019344:Lactic Acid