Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, E(opsin)-1 in the rat opsin gene.
It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.
Ahmad
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Department of Cell Biology and Anatomy and Ophthalmology, University of Nebraska Medical Center, Omaha 68198, USA.
D000818:Animals; D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005069:Evaluation Studies as Topic; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018257:Helix-Loop-Helix Motifs; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D017948:Retinal Rod Photoreceptor Cells / Q000166:cytology / Q000378:metabolism*; D017299:Rod Opsins / Q000235:genetics*; D014157:Transcription Factors / Q000096:biosynthesis*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D017299:Rod Opsins; D014157:Transcription Factors; C499318:Ascl1 protein, rat