[Study of the reactivity of giant cell tumors of bones to different lectins].
The authors have examined 18 cases of giant cell bone tumours using various lectins. Type I stromal cells resembling fibroblasts and participating in the construction of matrix were Con A positive. The intensity of Con A binding and the number of positive cells increased with increasing stage. The nature and intensity of PNA-lectin binding in giant cells, after digestion with neuraminidase, varied according to the stage. While in Group I giant cells, 30 % of cells were negative and, in the great majority of cells, the reaction was limited to a clearly defined segment of the membrane, in Group III tumours, the proportion of negative cells was approximately 1 % and a diffuse and very intense intracytoplasmic reaction was observed in 60 % of the positive cells. According to the authors, the histochemical study of lectins could help classify giant cell tumours.
Illés
T
T
Université de Medecine de Pécs, Service d'Orthopedie, Hungary.
Dubousset
J
J
Szendröi
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000378:metabolism* / Q000473:pathology; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D037102:Lectins
Etude de la reactivite des tumeurs a cellules geantes des os a differentes lectines.