title: [The role of TPS in the diagnosis of prostatic carcinoma].
abstract: From June 1993 to July 1994 we treated 136 male patients affected by dysuria with hematic dosage of TPS and PSA, with DRE, transrectal echography and prostatic biopsy using an echograph. The patients treated were divided into two groups: A and B. Group A (TPS cut-off of 75 U/l) was made up of 91 patients, ages ranging from 41 to 85 years (average 72.5 years). Group B (TPS cut-off > 75 U/l) was made up of 45 patients, ages ranging from 39 to 88 years (average 75.1 years). In group A, 22 patients (24.2%) resulted as suffering from prostatic carcinoma, 4 (4.3%) resulted as suffering from prostatic phlogosis, and 65 (71.4%) resulted as suffering from BPH. In group B, 6 (13.3%) were affected by prostatic heteroplasia, 2 (4.4%) were affected by prostatic phlogosis, and 37 (82.2%) were affected by BPH. The TPS had a sensibility of 21.4% and a specificity of 66.3%. A comparison of the data obtained in the two groups did not reveal any significant differences. In this study the TPS showed a poor diagnostic reliability as a biologic marker of prostatic carcinoma.
authors.affiliation: Presidio Ospedaliero Cannizzaro, Servizio di Urologia.
authors.forename: P
authors.initials: P
authors.lastname: Panella
authors.forename: F
authors.initials: F
authors.lastname: Grasso-Leanza
authors.forename: G
authors.initials: G
authors.lastname: Scarpignato
authors.forename: P
authors.initials: P
authors.lastname: Pepe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011237:Predictive Value of Tests; D011469:Prostatic Diseases / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000276:immunology*
chemical_list: D014408:Biomarkers, Tumor; D010455:Peptides; C089984:tissue polypeptide specific antigen
vernacular_title: Ruolo del TPS nella diagnosi del carcinoma prostatico.