Dehydroepiandrosterone and insulinaemia.
Low dehydroepiandrosterone (DHEA) and hyperinsulinaemia are assumed to be risk factors of atherosclerosis. Exogenous hyperinsulinaemia during hyperinsulinaemic clamp decreases DHEA. We have evaluated interaction of these hormones during 2 weeks of therapeutic starvation in 11 obese patients (mean BMI 41.2 kg/m2), 5 nondiabetics and 6 diabetics with diet only therapy. Comparing diabetics with normals we have found no differences in BMI and blood DHEA, DHEAS and insulin levels. We have found a light implication of negative correlation of insulin to DHEA and DHEAS level in diabetics (r = -0.71, -0.73, p = 0.16, 0.18). During starvation insulinaemia is declining, DHEA initial increase is followed by a decrease (r = 0.93, p = 0.01). We conclude that insulin decrease during starvation could be a cause of DHEA decrease. This finding is unexpected according to the potential of exogenous insulin to suppress DHEA. Further investigation of endogenous DHEA and insulin relation is necessary.
Svacina
S
S
IIIrd Dept. of Internal Medicine, 1st Medical Faculty, Charles Universtiy, Prague, Czech Republic.
Sonka
J
J
Haas
T
T
D001161:Arteriosclerosis / Q000097:blood*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood / Q000172:deficiency*; D019314:Dehydroepiandrosterone Sulfate; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D009765:Obesity / Q000097:blood; D012307:Risk Factors
D007328:Insulin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate