title: Linear skeletal muscle ventricle: a pilot study.
abstract: We have developed a new skeletal muscle ventricle (LSMV) powered by linear contraction of the latissimus dorsi muscle (LD). This consists of two bellows of different diameters joined by a connector containing a valve. The smaller bellows is connected to the left atrium with a valve, and the larger bellows is connected to the aorta. The caudal tendon of the LD is attached to the connector. LD contraction pulls the connector to compress the larger bellows and to elongate the smaller bellows. This motion closes the valve in the connector, ejects blood in the larger bellows, and draws blood into the smaller bellows. LD relaxation allows aortic blood to regurge into the larger bellows. Therefore, the LD is stretched. In acute canine experiments, the stroke work and power output of the LSMV measured 0.214 J and 0.135 W with a filling pressure of 4.3 mm Hg.
authors.affiliation: Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: A
authors.initials: A
authors.lastname: Furuse
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D018421:Cardiomyoplasty; D004285:Dogs; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D010865:Pilot Projects; D011183:Postoperative Complications; D013318:Stroke Volume / Q000502:physiology; D013710:Tendons / Q000502:physiology; D016276:Ventricular Function