[Cerebral blood flow and thrombocyte aggregation at different times of hypokinesia and their regulation by antiaggregants].
Changes in local cerebral blood flow and in microcirculatory channels in the cortex of rat brain were studied in conditions of early and remote hypokinesia. The rheological parameters of blood were studied in patients which stayed in ber for a long time in traumatological hospitals. We showed that by the 60th day of hypokinesia and in conditions of active readaptation the disordered cerebral blood flow starts to stabilize and tendency to normalization of some parameters of the cerebral blood flow and microcirculatory channels become clearly seen. The study of the functional state of the platelets showed that prescription of antiaggregants along with physical training can prevent thromboembolic aggravations associated with hypokinesia.
Akopian
V P
VP
Balian
L S
LS
Edigarova
L V
LV
Kocharian
A Zh
AZh
Mirzoian
N R
NR
D000222:Adaptation, Physiological / Q000187:drug effects; D000328:Adult; D000818:Animals; D001510:Bed Rest; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D018476:Hypokinesia / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012016:Reference Values; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors
Mozgovoĭ krovotok, agreguemost' trombotsitov v razlichnye sroki gipokinezii i ikh reguliatsiia antiagregantami.