Detection of microcin production by pathogenic Escherichia coli isolates from children with acute diarrhoea.
Production of low molecular weight antibiotic substances was detected among pathogenic Escherichia coli isolates from diarrhoeal children's feces during evaluation of a rotavirus vaccine in Caracas city. One of these products, microcin V627a, was partially purified and characterized. Microcin synthesis and immunity system appears not to be plasmid determined and the antibiotic was produced to a high level in minimal medium during the stationary phase. This microcin has many features in common with the mccA15 family.
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Sección de Investigación en Enfermedades Entéricas, Instituto de Biomedicina, Caracas, Venezuela.
Rodríguez Lemoine
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D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001430:Bacteriocins / Q000096:biosynthesis; D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D007223:Infant; D008970:Molecular Weight
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C020411:microcin