Cranial irradiation with Gaalas laser leads to naloxone reversible analgesia in rats.
Laser irradiation of the rat cranium can produce analgesia. The present experiment investigated the mechanism of such action. 27 rats received all possible combinations of laser (0, 6.4, and 12J/cm2) and naloxone (0, 5, and 10 mg/kg) prior to a hot plate test. Laser (820 nm, KHz pulsing, Omega Laser Systems, London) was applied to the rats' skulls and hind paw lick latencies (in seconds) were recorded immediately, 30 min., and 24 hr. after the administration of treatment. When animals were tested immediately following laser irradiation at 12J/cm2 significant analgesia resulted. Treatment with naloxone at either dose antagonised this effect, but naloxone produced no significant hyperalgesia when given alone. This suggests that opioid peptide mechanisms mediate the analgesic action of low-intensity laser irradiation of the cranium.
Wedlock
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PM
School of Behavioural and Communication Sciences, University of Ulster at Jordanstown, Newtownabbey, County Antrim, Northern Ireland.
Shephard
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RA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000528:radiation effects*; D016371:Cranial Irradiation / Q000295:instrumentation*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D007834:Lasers; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011957:Receptors, Opioid / Q000187:drug effects / Q000528:radiation effects
D011957:Receptors, Opioid; D009270:Naloxone