[Detection of T-antigen in colorectal adenocarcinoma and polyps].
Galactose oxidase method was employed to detect the beta-D-Gal (1-->3) -D-Gal NAc residue of T-antigen present in the large intestinal mucus of 156 subjects. The positive rates of the test were 84.4%, 29.1%, and 7.2% in the mucus samples obtained from 32 patients with colorectal adenocarcinomas, 55 with polyps and 69 controls respectively. Chi-square test demonstrated that there were significant differences between the group of carcinoma and control (P < 0.001) as well as between also polyp and control (P < 0.01). The test had a high sensitivity (84.4%) and specificity (92.8%) in the diagnosis of colorectal cancer and may be used as a practical mass screening test for colorectal neoplasms.
Xu
S
S
Department of Gastroenterology, Huashan Hospital, Shanghai Medical University.
Lu
Y
Y
Wang
Q
Q
D000230:Adenocarcinoma / Q000276:immunology*; D000236:Adenoma / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D003110:Colonic Neoplasms / Q000276:immunology*; D003111:Colonic Polyps / Q000276:immunology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000276:immunology; D012004:Rectal Neoplasms / Q000276:immunology*; D012680:Sensitivity and Specificity
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; C016467:Thomsen-Friedenreich antigen