Lipid apheresis: from a heroic treatment to routine clinical practice.
Lipid apheresis has developed from a heroic treatment into a routine clinical therapy and currently is the major indication for performing extracorporeal plasma therapy. Whereas it was once reserved for patients with homozygous familial hypercholesterolemia, today it has a place in the secondary prevention of severe coronary heart disease when low-density lipoprotein (LDL)-cholesterol level exceeds 150 mg/dl, despite conservative treatment, in any type of primary hypercholesterolemia. Unselective plasma exchange has been replaced by a variety of selective procedures. The efficacy of the treatment can be maximized by combining LDL apheresis with the use of cholesterol synthesis enzyme inhibitors. Clinical studies have shown that drastic cholesterol reduction can result in regression of coronary atherosclerosis as well as in reduced cardiac morbidity and mortality. Technical progress comprises improved selectivity, online regeneration of adsorbers, and LDL adsorption from whole blood. Recently, a new LDL hemoperfusion procedure was successfully tested in a clinical pilot study; blood is passed directly over a lipid sorbent without prior plasma separation. If this system is demonstrated to be safe and effective in clinical Phase III trials, a further qualitative step in the rapid development of LDL apheresis will have made.
Bosch
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Nephrological Department, Klinikum Grosshadern, University of Munich, Germany.
D000327:Adsorption; D001672:Biocompatible Materials / Q000378:metabolism; D001781:Blood Component Removal / Q000592:standards / Q000639:trends*; D008078:Cholesterol, LDL / Q000302:isolation & purification / Q000378:metabolism; D016264:Dextran Sulfate / Q000378:metabolism; D006464:Hemoperfusion; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D006951:Hyperlipoproteinemias / Q000628:therapy; D050356:Lipid Metabolism; D008055:Lipids / Q000302:isolation & purification*; D017270:Lipoprotein(a) / Q000302:isolation & purification; D006435:Renal Dialysis; D012307:Risk Factors
D001672:Biocompatible Materials; D008078:Cholesterol, LDL; D008055:Lipids; D017270:Lipoprotein(a); D006493:Heparin; D016264:Dextran Sulfate