Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine.
These studies determined the effect of the saturated fat source in infant formula on the expression of calbindin-D9k (CaBP-9k). Piglets were fed from birth to 8 d with milk or formula containing saturated fatty acids as medium-chain triglycerides (MCT), coconut oil, palm oil (Palm 1), or synthesized triglycerides with 16:0 directed to the sn-2 position (Palm 2). Levels of intestinal CaBP-9k mRNA were significantly (P < 0.01) higher in piglets fed formula with MCT than in piglets fed the other formula or milk; and higher in piglets fed the Palm-1 than in piglets fed Palm-2 formula. This is the first evidence that MCT alter piglet intestinal CaBP-9k mRNA.
Devlin
A
A
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Innis
S M
SM
Wall
K
K
Krisinger
J
J
D000818:Animals; D064026:Calbindins; D000074263:Coconut Oil; D004041:Dietary Fats; D005260:Female; D006801:Humans; D007223:Infant; D007225:Infant Food; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008892:Milk; D000073878:Palm Oil; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis*; D013552:Swine; D014158:Transcription, Genetic; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*
D064026:Calbindins; D004041:Dietary Fats; D010938:Plant Oils; D012333:RNA, Messenger; D064030:S100 Calcium Binding Protein G; C576506:S100G protein, human; D014280:Triglycerides; D000073878:Palm Oil; D000074263:Coconut Oil