Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer unrelated peripheral blood progenitor cell donor.
We describe a volunteer unrelated peripheral blood progenitor cell donor with previously diagnosed dermatitis herpetiformis in whom the administration of G-CSF for the mobilization of precursor cells induced acute iritis. G-CSF has been administered to healthy people with minimal side-effects but when used in patients with autoimmune disorders worsening of symptoms or new manifestations may be a potential concern.
Parkkali
T
T
Department of Medicine, Helsinki University Central Hospital, Finland.
Volin
L
L
Sirén
M K
MK
Ruutu
T
T
D000208:Acute Disease; D000328:Adult; D001782:Blood Donors; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003874:Dermatitis Herpetiformis / Q000150:complications*; D006084:Graft Rejection; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006680:HLA Antigens / Q000097:blood; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007500:Iritis / Q000139:chemically induced*; D008297:Male; D014838:Volunteers
D006680:HLA Antigens; D016179:Granulocyte Colony-Stimulating Factor