title: Human lymphocytes are more susceptible to measles virus than granulocytes, which is attributable to the phenotypic differences of their membrane cofactor protein (CD46).
abstract: Membrane cofactor protein (MCP, CD46) of the complement system is a measles virus (MV) receptor. Human lymphocytes express a heavily glycosylated (H) and a lightly glycosylated (L) form of MCP, which confers a two-band profile on SDS-PAGE the ratio of which is controlled genetically and organ-specifically. In contrast, granulocytes express a single heavily glycosylated form regardless of lymphocyte MCP phenotype. We investigated susceptibility to MV of granulocytes and lymphocytes from individuals with different lymphocyte MCP phenotypes. In any individual, granulocytes were > 10-fold less susceptible to MV than lymphocytes, and the lymphocytes with predominant H form were generally less susceptible to those with an increasing amount of L form. Thus, lymphocytes always exhibit high susceptibility to MV compared to granulocytes in all individuals. This finding may explain the lymphopenia and immunosuppression observed secondary to MV infection.
authors.affiliation: Department of Immunology, Center for Adult Diseases Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kurita
authors.forename: Y
authors.initials: Y
authors.lastname: Yanagi
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: S
authors.initials: S
authors.lastname: Nagasawa
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Seya
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis / Q000145:classification*; D016466:CHO Cells; D006224:Cricetinae; D006098:Granulocytes / Q000276:immunology / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology / Q000821:virology*; D008459:Measles virus / Q000276:immunology*; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000032:analysis / Q000145:classification*; D011991:Receptors, Virus / Q000032:analysis / Q000145:classification*; D012680:Sensitivity and Specificity
chemical_list: D015703:Antigens, CD; C497857:CD46 protein, human; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011991:Receptors, Virus