[111IN-octreotide and 123I-MIBG scintigraphy in the diagnosis of small intestinal carcinoid tumors--results of a comparative investigation].
OBJECTIVE
This study compares the diagnostic value of 111In-Octreotide- and 123I-MIBG scintigraphy in the diagnostic imaging of carcinoids and correlates the results with CT findings.


METHODS
Twenty-eight patients underwent octreotide-, MIBG scintigraphy and CT examination within a short time period.


RESULTS
In 13/15 preoperatively examined patients somatostatin receptor expression of the tumor was demonstrated; MIBG-uptake was found in 8/15 cases. Octreotide and MIBG scintigraphy revealed liver metastases in 26 and 19 cases, respectively. CT-examinations detected liver metastases in 22 cases. The number of metastatic lesions found by MIBG and CT was lower than with octreotide. In 3 patients unknown mediastinal lesions were detected by the octreotide scan, 2/3 did not show MIBG uptake. In 5 non-hormone secreting tumors shown by octreotide scintigraphy, no MIBG uptake was found. With respect to the diagnostic accuracy octreotide scintigraphy appeared superior to MIBG.


CONCLUSIONS
MIBG scans do not provide additional diagnostic information compared to octreotide scintigraphy. MIBG scintigraphy may be potentially useful in terms of planning 131I-MIBG therapy only.
Dresel
S
S
Klinik und Poliklinik für Nuklearmedizin, Ludwig-Maximilians-Universität Mäunchen, Deutschland.
Tatsch
K
K
Zachoval
R
R
Hahn
K
K
D019797:3-Iodobenzylguanidine; D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015282:Octreotide / Q000031:analogs & derivatives*; D011859:Radiography; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed
D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C094279:indium-111-octreotide; D019797:3-Iodobenzylguanidine; D015282:Octreotide
111In-Octreotide- und 123I-MIBG-Szintigraphie in der Diagnostik von Dünndarmkarzinoiden--Ergebnisse einer vergleichenden Untersuchung.