title: [The clenbuterol treatment of patients with the chronic obstructive syndrome].
abstract: We have studied the effect of a new long acting bronchodilator: CLENBUTEROL, in 10 patients suffering from chronic obstructive diseases. All patients received 1 tablet of Clenbuterol, then we measured the following parameters in each patient, 2 and 6 hours after the drug administration: VC (vital capacity), FEV1 (forced expiratory volume in the first second of forced expiration), FEV1 x 100/VC, Raw (airways resistance), RV (residual volume). In all patients, excepting one of them, we registered a modification of all or some of the parameters 2 hours after drug administration. The bronchodilator effect was still present at 6 hours after drug administration. This data suggest that Clenbuterol induced a significant and long acting improvement of chronic obstruction; this drug might offer the advantage of sustained effect in patients suffering from chronic bronchospastic obstruction.
authors.affiliation: Institutul de Pneumoftiziologie, Marius Nasta, Bucureşti.
authors.forename: A A
authors.initials: AA
authors.lastname: Ionescu
authors.forename: G
authors.initials: G
authors.lastname: Bistriceanu
authors.forename: M
authors.initials: M
authors.lastname: Bogdan
authors.forename: S
authors.initials: S
authors.lastname: Duţu
mesh_terms: D000328:Adult; D001986:Bronchial Spasm / Q000188:drug therapy / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002976:Clenbuterol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D002976:Clenbuterol
vernacular_title: Tratamentul cu Clenbuterol al bolnavilor cu sindrom obstructiv cronic.