(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist.
Pellicciari
R
R
Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.
Raimondo
M
M
Marinozzi
M
M
Natalini
B
B
Costantino
G
G
Thomsen
C
C
D000818:Animals; D001667:Binding, Competitive; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007668:Kidney; D015394:Molecular Structure; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001643:Bridged Bicyclo Compounds; D010716:Phosphatidylinositols; D018094:Receptors, Metabotropic Glutamate; C100726:UPF 596; D018698:Glutamic Acid; D005998:Glycine