title: Increase of aldosterone secretion following acute haloperidol administration: possible clinical implications.
abstract: The present study was designed to investigate the effect of haloperidol on plasma corticosteroid levels in a small sample of unmediated psychiatric patients requiring acute care. Seven young male normotensive subjects in metabolic balance received a single dose of haloperidol (2 mg i.v.). Blood samples were collected for the radioimmunoassay of plasma renin activity, cortisol and aldosterone concentration at baseline and 3, 6, 12 and 24 h after injection. In five out of seven patients a significant, transient elevation of plasma aldosterone level was observed within 12 h from administration. In contrast, plasma renin activity and cortisol concentration were unchanged. Possible clinical implications of the neuroleptic-associated aldosterone elevations are discussed.
authors.affiliation: Department of Biomedical Sciences and Biotechnologies, Brescia University School of Medicine, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Liberini
authors.forename: E
authors.initials: E
authors.lastname: Nisoli
authors.forename: C
authors.initials: C
authors.lastname: Missale
authors.forename: C
authors.initials: C
authors.lastname: Turrina
authors.forename: G B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: R
authors.initials: R
authors.lastname: Caruso
authors.forename: P F
authors.initials: PF
authors.lastname: Spano
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000097:blood / Q000494:pharmacology*; D006220:Haloperidol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male
chemical_list: D014150:Antipsychotic Agents; D000450:Aldosterone; D006220:Haloperidol