Experimental colonic carcinogenesis: a new animal model.
The aim of this work was to develop an animal model of accessible colonic tumours simulating human carcinogenesis. A segment of the colon was exteriorized to the skin in 60 rats and swabbed with N-methyl-N-nitrosourea. All the animals developed tumoral abnormalities or frank dysplasic tissue 7 months after the beginning of the experiment. This animal model which closely mimics human colonic carcinogenesis is particularly interesting because tumour development can be monitored in live animals without interrupting normal intestinal functions.
Meunier
B
B
Department of Digestive Surgery, Centre Hospitalier, Rennes, France.
Bardaxoglou
E
E
Lakehal
M
M
Chenal
C
C
Lancien
G
G
Campion
J P
JP
Launois
B
B
D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013997:Time Factors
D002273:Carcinogens; D008770:Methylnitrosourea