title: Association of human herpesvirus 6 infection with exanthem subitum in Belem, Brazil.
abstract: Recent human herpesvirus 6 (HHV-6) infection was detected in cases of exanthem subitum (ES) involving four children, aged 10 to 24 months, between April and August 1994, in Belém, Brazil. By using the indirect immunofluorescence antibody assay (IFA), significant increases (at least eight times) in antibody concentrations were noted from the acute to the convalescent serum samples, with titers ranging from < 1:10/1:80 to < 1:10/1:640 (patients 3 and 2, respectively). All children had high fever (over 39 degrees C) for three days, followed by generalized, maculo-papular skin rash. A physical examination of the children also revealed concomitant, cervical lymph node swelling and tonsillar pharyngitis in two of them.
authors.affiliation: Serviço de Virologia Geral, Instituto Evandro Chagas, Pará, Brasil.
authors.forename: R B
authors.initials: RB
authors.lastname: de Freitas
authors.forename: A C
authors.initials: AC
authors.lastname: Linhares
authors.forename: C S
authors.initials: CS
authors.lastname: Oliveira
authors.forename: R H
authors.initials: RH
authors.lastname: Gusmão
authors.forename: M I
authors.initials: MI
authors.lastname: Linhares
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D001938:Brazil; D002675:Child, Preschool; D005077:Exanthema Subitum / Q000175:diagnosis / Q000821:virology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D000914:Antibodies, Viral