[Differential immunohistochemical diagnosis of tumors of the human central nervous system using monoclonal antibodies].
67 brain tumors were studied using monoclonal antibodies against glial fibrillary acid protein (GFAP), neurofilaments, proteoglycan, laminin and vimentin. All the astrocytic tumors gave positive reaction to GFAP, but anaplastic tumors of this type were less reactive. Medulloblastomas when treated with GFAP showed two cell lines, astrocytic and neuronal. A positive reaction to laminin and proteoglycan was observed in the vessels of neuroepithelial tumors. Anaplastic astrocytomas were more reactive to vimentin.
Vial'tseva
Iu Iu
IuIu
Bukhvalov
I B
IB
Vasilov
R G
RG
D000911:Antibodies, Monoclonal; D001254:Astrocytoma / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005909:Glioblastoma / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis; D008527:Medulloblastoma / Q000175:diagnosis; D009363:Neoplasm Proteins / Q000032:analysis*; D016900:Neurofilament Proteins / Q000032:analysis; D011509:Proteoglycans / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D007797:Laminin; D009363:Neoplasm Proteins; D016900:Neurofilament Proteins; D011509:Proteoglycans; D014746:Vimentin
Differentsial'naia immunotsiokhimicheskaia diagnostika opukholeĭ tsentral'noĭ nervnoĭ sistemy cheloveka s pomoshch'iu monoklonal'nykh antitel.