title: HPV-11- and HPV-16-associated oral verrucous carcinoma.
abstract: BACKGROUND
  Verrucous carcinoma is a slowly growing, well-differentiated neoplasm with a predilection for the oral cavity.
  
  
  OBJECTIVE
  Data on the association of human papillomavirus (HPV) with oral verrucous carcinoma are very scarce. We searched for the presence of HPV in different stages of the tumour in a patient repeatedly treated by means of surgery, cryotherapy, radiotherapy and chemotherapy over a decade.
  
  
  METHODS
  HPV DNA was detected in archival tumour tissue by nested PCR. HPV types were identified based on restriction fragment analysis.
  
  
  RESULTS
  HPV type 11 was found in 1 early-stage and HPV 16 in 2 late-stage biopsy specimens of the tumour.
  
  
  CONCLUSIONS
  Our findings provide further evidence for a role of HPV in oral verrucous carcinoma. The case history emphasizes the importance of a joint clinicopathological approach to this tumour.
authors.affiliation: Department of Dermatology, University Hospital, Zurich, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Lübbe
authors.forename: A
authors.initials: A
authors.lastname: Kormann
authors.forename: V
authors.initials: V
authors.lastname: Adams
authors.forename: S
authors.initials: S
authors.lastname: Hassam
authors.forename: K W
authors.initials: KW
authors.lastname: Grätz
authors.forename: R G
authors.initials: RG
authors.lastname: Panizzon
authors.forename: G
authors.initials: G
authors.lastname: Burg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018289:Carcinoma, Verrucous / Q000473:pathology / Q000628:therapy / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology / Q000821:virology; D009062:Mouth Neoplasms / Q000473:pathology / Q000628:therapy / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology / Q000628:therapy; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology / Q000628:therapy
chemical_list: D004279:DNA, Viral