[Membrane-active preparations as correctors of the nephrotoxicity of gentamicin].
At intracutaneous gentamicine injections in rats (dose 50 mg/kg) within 10 days the simultaneous application of anticalcium drugs makes nephrotoxic signs more pronounced; whereas antioxidants and essenciale make them less pronounced. Phospholipid complex, containing phosphatidylserin, sphingomyelin, and phosphatidylethanolamine does not exhibit a marked nephroprotective effect. The found character of changes in content of phosphoinozytols in urine indirectly confirms the role of disturbances of their metabolism in mechanism of aminoglycoside nephrotoxicity.
Veshkurtseva
I M
IM
Ortenberg
E A
EA
Bychkova
V G
VG
Zhikhareva
A I
AI
Chabanova
M K
MK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D000975:Antioxidants / Q000493:pharmacokinetics / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002121:Calcium Channel Blockers; D005839:Gentamicins
Membranoaktivnye preparaty kak korrektory nefrotoksichnosti gentamitsina.