title: Prevalence of factor V Leiden in a Canadian blood donor population.
abstract: OBJECTIVE
  To determine the prevalence of factor V Leiden in a Canadian blood donor population.
  
  
  METHODS
  Cross-sectional laboratory study.
  
  
  METHODS
  Hamilton Centre of the Canadian Red Cross Society.
  
  
  METHODS
  Volunteer donors who attended Hamilton Centre blood donor clinics over a 4-day period in August 1994; blood samples from 356 people were evaluable.
  
  
  METHODS
  Presence of factor V Leiden.
  
  
  RESULTS
  Factor V Leiden was detected in 19 of the 356 people, for a prevalence rate of 5.3% (95% confidence interval 3.0% to 7.6%). All 19 people were shown to be heterozygous for the mutation.
  
  
  CONCLUSIONS
  Factor V Leiden is common in the Canadian population. Its prevalence is similar to that reported in other Western countries. These data are relevant in the clinical management of patients at risk for venous thrombosis and those with recurrent thrombotic disorders.
authors.affiliation: Department of Pathology, McMaster University, Hamilton, Ont.
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: P A
authors.initials: PA
authors.lastname: Henderson
authors.forename: M A
authors.initials: MA
authors.lastname: Blajchman
mesh_terms: D001483:Base Sequence; D001782:Blood Donors; D003430:Cross-Sectional Studies; D004247:DNA / Q000235:genetics*; D005165:Factor V / Q000032:analysis* / Q000235:genetics; D006580:Genetic Carrier Screening; D006801:Humans; D008969:Molecular Sequence Data; D009864:Ontario; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D013927:Thrombosis / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D004247:DNA