Acute lung injury following lung resection: is one lung anaesthesia to blame?
Further examination of the parameters of oxidative stress, perioperative changes in the vasoregulatory mechanisms of the pulmonary circulation, and characterisation of the endothelial insult that probably occurs in all patients undergoing lung resection is necessary if the operative conditions under which lung surgery is carried out are to be optimised. Perhaps, then, more insight might be gained into how to improve preservation of lungs for transplantation and how to protect the lung from significant injury following resection.
Williams
E A
EA
National Heart and Lung Institute, Royal Brompton Hospital, London, UK.
Evans
T W
TW
Goldstraw
P
P
D000768:Anesthesia, General / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D008171:Lung Diseases / Q000601:surgery*; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000209:etiology* / Q000503:physiopathology; D015427:Reperfusion Injury / Q000209:etiology; D014661:Vasoconstriction