title: The accuracy center of a eukaryotic ribosome.
abstract: Mutations in yeast ribosomal proteins and ribosomal RNAs have been shown to affect translational fidelity. These mutations include: proteins homologous to Escherichia coli's S4, S5, and S12; a eukaryote specific ribosomal protein; yeast ribosomal rRNA alterations at positions corresponding to 517, 912, and 1054 in 16S E. coli rRNA and to 2658 in the sarcin-ricin domain of 23S E. coli rRNA. Overall there appears to be a remarkable conservation of the accuracy center throughout evolution.
authors.affiliation: Department of Biological Sciences, University of Illinois at Chicago, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Liebman
authors.forename: Y O
authors.initials: YO
authors.lastname: Chernoff
authors.forename: R
authors.initials: R
authors.lastname: Liu
mesh_terms: D005656:Fungal Proteins / Q000235:genetics*; D014176:Protein Biosynthesis; D012331:RNA, Fungal / Q000235:genetics*; D012335:RNA, Ribosomal / Q000235:genetics*; D015203:Reproducibility of Results; D012269:Ribosomal Proteins / Q000235:genetics*; D012270:Ribosomes; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D005656:Fungal Proteins; D012331:RNA, Fungal; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins