The treatment of hyposmia with intranasal steroids.
Hyposmia is a neglected symptom in patients with rhinitis. We studied 25 patients presenting with perennial rhinitis. Fifteen patients expressed hyposmia as a significant symptom. University of Pennsylvania smell identification test (UPSIT) and visual analogue scales (VAS) were used to score the symptoms of hyposmia, nasal obstruction and nasal discharge before and after six weeks treatment with betamethasone sodium phosphate drops. Those patients with initial symptoms of hyposmia significantly improved their UPSIT scores (p = 0.00009) and their VAS scores for hyposmia (p = 0.00133). Despite a significant decrease in the sensation of nasal obstruction, the non-hyposmics showed no increase in UPSIT scores after betamethasone therapy. There was no clear correlation between UPSIT results and other symptom scores. The judicious use of betamethasone drops in the treatment of rhinogenic hyposmia can be recommended.
Golding-Wood
D G
DG
Royal National Throat, Nose and Ear Hospital, London, UK.
Holmstrom
M
M
Darby
Y
Y
Scadding
G K
GK
Lund
V J
VJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000209:etiology; D012221:Rhinitis, Allergic, Perennial / Q000150:complications*
C028994:betamethasone sodium phosphate; D001623:Betamethasone