Treatment of chronic idiopathic urticaria with topical steroids. An open trial.
Twenty-three patients with chronic idiopathic urticaria and 3 patients with urticaria pigmentosa received a 2-week treatment with daily application of potent topical steroid using plastic occlusion. Seventy per cent of the chronic urticaria patients had a statistically significant, immediate response, which, however, did not last until the final evaluation after 1.5 years. Relapse occurred after on average 3 weeks, but 39% reported less severity. The 3 patients with urticaria pigmentosa remained free from attacks for 6 to 9 months, after which they gradually relapsed. Two women were diagnosed during the follow-up period to have a carcinoma of the breast, and one patient developed systemic lupus erythematosus.
Ellingsen
A R
AR
Department of Dermatology, University of Aarhus, Marselisborg Hospital, Denmark.
Thestrup-Pedersen
K
K
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology; D002908:Chronic Disease; D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D012008:Recurrence; D012189:Retrospective Studies; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014581:Urticaria / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014582:Urticaria Pigmentosa / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D002990:Clobetasol