title: [Comparative study of buprenorphine and its combination to ketoprofen or propacetamol for postoperative analgesia in urologic surgery].
abstract: OBJECTIVE
  To compare the analgesic effect of subcutaneous buprenorphine alone and in combination with propacetamol and ketoprofen following urologic surgery.
  
  
  METHODS
  Open randomized clinical trial.
  
  
  METHODS
  Sixty ASA II/III patients undergoing urologic surgery.
  
  
  METHODS
  The patients were randomized into three groups to receive either buprenorphine (0.3 mg subcutaneous) on demand (group 1, n = 20), or a combination of buprenorphine (0.3 mg)-propacetamol (2 g)-ketoprofen (100 mg) by intravenous route over 2 hours followed by an infusion of propacetamol (2 g) and ketoprofen (100 mg) at a constant rate over. The remaining 22 hours (group 2, n = 20), or the same loading dose as in group 2 prolonged by a continuous infusion of buprenorphine (0.3 mg), propacetamol (2 g) and ketoprofen (100 mg) over the same period (group 3, n = 20). Visual analogue scale pain scores (0-10) were assessed every hour during the 24 hours of the study. When the VAS score exceeded 5, an additional dose of 0.3 mg of buprenorphine was administered.
  
  
  RESULTS
  Groups were similar for age, surgery, anaesthesia and initial pain levels. Compared to group 1, the onset of analgesia was earlier in groups 2 and 3 at the 1st hour (P < 0.05); the level of analgesia was lower at the 3rd hour (P < 0.05). The maintenance of this analgesia level required constant buprenorphine administration. Buprenorphine requirements were decreased to 56% and 37% in groups 2 and 3 respectively, compared to group 1 (P < 0.05). Incidence of nausea and vomiting was lowered to 15% in group 3 (P < 0.05).
  
  
  CONCLUSIONS
  A combination of buprenorphine, propacetamol and ketoprofen provides effective postoperative analgesia with a low incidence of nausea and vomiting and decreased requirements of buprenorphine.
authors.affiliation: Département d'anesthésie-réanimation III, hôpital Pellegrin-Tondou, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Tauzin-Fin
authors.forename: S
authors.initials: S
authors.lastname: Delort-Laval
authors.forename: Y
authors.initials: Y
authors.lastname: Guenard
authors.forename: M C
authors.initials: MC
authors.lastname: Krol-Houdek
authors.forename: J M
authors.initials: JM
authors.lastname: Muscagorry
authors.forename: P
authors.initials: P
authors.lastname: Maurette
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use*; D002047:Buprenorphine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014570:Urologic Diseases / Q000601:surgery*
chemical_list: D000700:Analgesics; D000082:Acetaminophen; D002047:Buprenorphine; C063776:propacetamol; D007660:Ketoprofen
vernacular_title: Etude comparative de la buprénorphine et de son association au kétoprofène et au propacétamol pour l'analgésie postopératoire en chirurgie urologique.