Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine.
Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose of trazodone was 150 mg in three cases and 300 mg in three cases. Carbamazepine, 400 mg/day, was coadministered for 4 weeks, and blood samples were taken before carbamazepine addition and at weekly intervals after the addition. Carbamazepine significantly (p < 0.01) decreased plasma concentrations of not only trazodone but also m-CPP at each week. On the average, plasma concentrations of trazodone and m-CPP at 4 weeks were 24 and 40% of the corresponding precarbamazepine values. This study thus suggests that carbamazepine coadministration decreases plasma concentrations of trazodone and m-CPP by inducing the metabolism of these compounds.
Otani
K
K
Department of Neuropsychiatry, Hirosaki University Hospital, Japan.
Ishida
M
M
Kaneko
S
S
Mihara
K
K
Ohkubo
T
T
Osanai
T
T
Sugawara
K
K
D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000097:blood*; D002220:Carbamazepine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000032:analysis / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000032:analysis / Q000378:metabolism; D014196:Trazodone / Q000008:administration & dosage / Q000097:blood*
D000927:Anticonvulsants; D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D017366:Serotonin Receptor Agonists; D002220:Carbamazepine; C015068:1-(3-chlorophenyl)piperazine; D014196:Trazodone