title: Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report.
abstract: Cyclosporin a is an endecapeptide that has been used clinically since 1978 as an immunosuppressant agent. Although cyclosporine appears to be uniformly beneficial in the treatment of a wide variety of disorders, its use may result in a number of side effects. One of the most important adverse effects is gingival overgrowth. This report relates a case of severe gingival overgrowth in a 31-year-old female who had received cyclosporine therapy in conjunction with a kidney transplant. Because of the severe gingival overgrowth, we analyzed a biopsy, which was positive for human papillomavirus. The case was treated and followed for 18 months.
authors.affiliation: University of Istanbul, Faculty of Dentistry, Department of Periodontology, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Sağlam
authors.forename: U
authors.initials: U
authors.lastname: Onan
authors.forename: M
authors.initials: M
authors.lastname: Soydinç
authors.forename: O
authors.initials: O
authors.lastname: Yilmaz
authors.forename: K
authors.initials: K
authors.lastname: Kiraç
authors.forename: M S
authors.initials: MS
authors.lastname: Sever
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000821:virology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications* / Q000821:virology
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine