Increase in vasopressin binding sites in the human choroid plexus in Alzheimer's disease.
Vasopressin binding sites were determined in the choroid plexus of five Alzheimer's disease patients and five non-demented controls using the 125I-labelled linear V1a-antagonist. The Alzheimer's disease patients showed a twofold increase in the density of vasopressin binding sites, whereas the increase in the affinity constant Kd did not reach significance.
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Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research.
van Zwieten
E J
EJ
Boer
G J
GJ
Ravid
R
R
Swaab
D F
DF
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000595:Amino Acid Sequence; D002831:Choroid Plexus / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017483:Receptors, Vasopressin / Q000378:metabolism*
D017483:Receptors, Vasopressin