title: Bronchioloalveolar carcinoma.
abstract: OBJECTIVE
  To review bronchioloalveolar carcinoma (BAC).
  
  
  METHODS
  English language articles were identified through a Melvyl Medline Search (1966 to 1995) and through the bibliographies of selected articles.
  
  
  RESULTS
  An increase in BAC appears to be responsible for the observed rise in the incidence of adenocarcinoma of the lung. Patients with BAC tend to be younger at diagnosis, are more likely to be female, and less likely to be cigarette smokers when compared with other patients with non-small-cell lung cancer (NSCLC). The etiology of this disease is unclear, but multiple environmental insults have been implicated. There are three subtypes of BAC and the symptoms and prognosis of the disease depend on the subtype and extent of disease, but are generally similar to other histologic types of NSCLC. The radiographic differential diagnosis is broad and includes both benign and malignant diseases. The treatment approach to patients with BAC is similar to those with other types of NSCLC.
  
  
  CONCLUSIONS
  BAC appears to be increasing in incidence, especially in young, nonsmoking females. Three subtypes of the disease exist and are responsible for the variable clinical presentations. Further epidemiologic investigation is needed to elucidate the etiology and pathogenesis of this unique disease.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California San Diego, School of Medicine 92103-8421, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Barkley
authors.forename: M R
authors.initials: MR
authors.lastname: Green
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D000367:Age Factors; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D008297:Male; D011379:Prognosis; D013902:Radiography, Thoracic; D012737:Sex Factors; D014057:Tomography, X-Ray Computed