Duration of filgrastim mobilization and apheresis yield of CD34+ progenitor cells and lymphoid subsets in normal donors for allogeneic transplantation.
Seventy-seven normal donors underwent leukapheresis for peripheral blood progenitor cell collection beginning on day 4 (n = 45) or day 5 (n = 32) of filgrastim mobilization (12 micrograms/kg/d). The two groups were comparable for age, weight, blood volumes processed during leukapheresis and target CD34+ cell dose to be collected. The day 5 schedule allowed a more consistent achievement of the target cell dose with one apheresis (P = 0.005) and resulted in the initial collection of a significantly larger number of CD34+ cells (P = 0.009). There was no statistically significant difference in the leukapheresis yield of lymphoid subsets and natural killer cells.
Anderlini
P
P
Department of Hematology and Laboratory Medicine, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Przepiorka
D
D
Huh
Y
Y
Lauppe
J
J
Miller
P
P
Sundberg
J
J
Seong
D
D
Champlin
R
R
Körbling
M
M
D000328:Adult; D018952:Antigens, CD34; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D016130:Immunophenotyping; D007937:Leukapheresis / Q000379:methods*; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D014184:Transplantation, Homologous
D018952:Antigens, CD34; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim