title: Recanalization of totally occluded saphenous vein grafts using local urokinase delivery with the Dispatch catheter.
abstract: Current techniques for the percutaneous revascularization of totally occluded vein grafts are limited by a low initial success rate, a significant incidence of distal embolization, and a high rate of early graft reclosure. This case report describes two patients in whom graft recanalization was attempted with the combined use of balloon angioplasty/intra-graft stent placement and local urokinase delivery using a new angiotherapy catheter. Successful recanalization was achieved in both patients without major complications, in spite of a large thrombus burden as demonstrated by angiography.
authors.affiliation: Department of Internal Medicine, Hartford Hospital, University of Connecticut 06102, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Glazier
authors.forename: H H
authors.initials: HH
authors.lastname: Bauer
authors.forename: F J
authors.initials: FJ
authors.lastname: Kiernan
authors.forename: C A
authors.initials: CA
authors.lastname: Primiano
authors.forename: J F
authors.initials: JF
authors.lastname: Mitchel
authors.forename: J E
authors.initials: JE
authors.lastname: Dougherty
authors.forename: D D
authors.initials: DD
authors.lastname: Waters
authors.forename: R G
authors.initials: RG
authors.lastname: McKay
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000209:etiology / Q000628:therapy*; D006083:Graft Occlusion, Vascular / Q000150:complications / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000008:administration & dosage*; D012501:Saphenous Vein; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator