[Effect of zhuchun pill on immunity and endocrine function of elderly with kidney-yang deficiency].
After randomly dividing 45 elderly males with Kidney-Yang Deficiency into Zhuchun Pill (ZCP) group and placebo (starch capsule) group by single blind method, and treating them for 3 months, we found that ZCP could greatly improve the main symptoms of Kidney-Yang Deficiency, P < 0.01 by comparison with control group: the 3H-TdR lymphocyte transformation (3H-TdR LCT) rate, level of serum C3, IgA, IgD, IgG & IgM went up (P < 0.01); contents of plasma adrenocortical hormone (ACTH), testosterone (T) and cyclic adenosine monophosphate (cAMP) increased (P < 0.01-0.001): the level of superoxide dismutase (SOD) in serum also increased while lipid peroxide (LPO) in plasma decreased (P < 0.01). But for control group, there were no remarkable changes after treatment, so it revealed that the improvement of Kidney-Yang Deficiency by ZCP is realized through regulating the organism's immunity and endocrine function as well as through scavenging the free radical agents.
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Wuxi No. 3 People's Hospital, Jiangsu.
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000368:Aged; D000375:Aging / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D013482:Superoxide Dismutase / Q000097:blood; D013739:Testosterone / Q000097:blood; D016711:Yang Deficiency / Q000188:drug therapy* / Q000503:physiopathology
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D007136:Immunoglobulins; D008054:Lipid Peroxides; D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D013482:Superoxide Dismutase