title: Experimental autoimmune hepatitis in mice following immunization with syngeneic liver proteins.
abstract: In this study, we describe the successful induction of experimental autoimmune hepatitis by immunizing inbred strains of mice with syngeneic liver antigens. Hepatic lesions, presumably based on autoimmune mechanisms, induced after 3 weekly immunizations were of only moderate degree. Of the various mouse strains used, C57BL/6 mice showed the most prominent histological changes of the liver, which were accompanied by elevated serum alanine aminotransferase levels. This system offers a potential model for further investigating experimental autoimmune hepatitis.
authors.affiliation: Department of Medicine, University of Mississippi, School of Medicine, Jackson, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Mihas
authors.forename: C
authors.initials: C
authors.lastname: Subramony
authors.forename: J L
authors.initials: JL
authors.lastname: Achord
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology* / Q000473:pathology; D005260:Female; D006520:Hepatitis, Animal / Q000097:blood / Q000276:immunology* / Q000473:pathology; D007114:Immunization; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011506:Proteins / Q000276:immunology* / Q000378:metabolism
chemical_list: D011506:Proteins; D000410:Alanine Transaminase