[Evaluation of the effectiveness of the use of pefloxacin in combined radiation-thermal injury].
The efficacy of pefloxacin, a novel promising antibacterial drug of the group of fluoroquinolones, was studied on mice against doxycycline in the prevention and treatment of infectious complications of radiation/thermal injury. According to the data on the effect of the antibiotics on the resistance to exogenic infection and the development of dysbacteriosis pefloxacin was recommended for the use in the scheme of combined therapy of radiation/thermal injury.
Makarov
G F
GF
Medical Research Radiological Centre, Russian Academy of Medical Sciences, Obninsk.
Budagov
R S
RS
Moiseeva
L A
LA
Boldueva
N G
NG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D002056:Burns / Q000150:complications*; D004318:Doxycycline / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015366:Pefloxacin / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000150:complications*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015366:Pefloxacin; D004318:Doxycycline
Otsenka éffektivnosti primeneniia pefloksatsina pri kombinirovannom radiatsionno-termicheskom porazhenii.