title: [Role of gram-negative bacterial endotoxins in infectious and non-infectious diseases].
abstract: The role of gram-negative bacteria endotoxin in infectious and non-infectious pathology is reviewed. It is shown that endotoxin may induce some injuries to the lungs, liver, kidney and blood vessels. It is suggested that intestinal microflora endotoxin may take part in the development of many pathological processes. The basis of the endotoxin effect is its capacity to interact with cell membrane. Intravascular blood coagulation and endotoxin shock resulting in the patient's death may occur at high doses of endotoxin.
authors.forename: V G
authors.initials: VG
authors.lastname: Likhoded
authors.forename: N D
authors.initials: ND
authors.lastname: Iushchuk
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Iakovlev
mesh_terms: D001424:Bacterial Infections / Q000503:physiopathology*; D056486:Chemical and Drug Induced Liver Injury; D006090:Gram-Negative Bacteria / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000382:microbiology; D007674:Kidney Diseases / Q000139:chemically induced; D008070:Lipopolysaccharides / Q000633:toxicity*; D008171:Lung Diseases / Q000139:chemically induced; D014652:Vascular Diseases / Q000139:chemically induced
chemical_list: D008070:Lipopolysaccharides
vernacular_title: Rol' éndotoksina gramotritsatel'nykh bakteriĭ v infektsionnoĭ i neinfektsionnoĭ patologii.