title: A pathogenic challenge model for adult northern bobwhite (Colinus virginianus) using a vaccine strain of Pasteurella multocida type 3.
abstract: A pathogenic challenge model causing approximately 50% mortality was developed in adult Northern bobwhite (Colinus virginianus) using Avichol, a live vaccine containing the Clemson University (CU) strain of Pasteurella multocida Type 3. A dose of 2300 or 3000 colony-forming units (CFU) of Avichol injected intramuscularly resulted in 30 to 75% mortality, whereas a dose of 230 CFU or less resulted in no mortality, and 58,720 CFU or more resulted in death in all birds challenged. Primary and secondary vaccination of Northern bobwhite with a formalinized anaculture of Avichol -derived P. multocida resulted in protection against challenge in three separate experiments. Dexamethasone treatment of birds during vaccination resulted in decreased protection against challenge exposure.
authors.affiliation: Department of Zoology, Oklahoma State University, Stillwater 74078, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Dabbert
authors.forename: R L
authors.initials: RL
authors.lastname: Lochmiller
authors.forename: R J
authors.initials: RJ
authors.lastname: Morton
authors.forename: K C
authors.initials: KC
authors.lastname: Powell
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D001715:Bird Diseases / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D003088:Colinus / Q000276:immunology*; D003907:Dexamethasone / Q000008:administration & dosage; D010326:Pasteurella Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D003907:Dexamethasone