title: LTD and LTP induced by transcranial magnetic stimulation in auditory cortex.
abstract: Using a system capable of relatively localized and rapidrate transcranial magnetic stimulation (rTMS), evoked trains of complex spikes were studied in rodent auditory cortex. Low rate rTMS from 1 to 10Hz produced a frequency-dependent increase in spike rate. Iterations of rTMS resulted in long-term potentiation (LTP)-like, and more durable long-term depression (LTD)-like changes in evoked spike rate. These observations generate new perspectives for studying mechanisms of learning and memory non-invasively as well as introducing some caveats for use of rTMS in humans.
authors.affiliation: Federal Institute for Neurobiology, Magdeburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Scheich
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D004574:Electromagnetic Fields; D005071:Evoked Potentials / Q000502:physiology; D005849:Gerbillinae; D017774:Long-Term Potentiation / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D010812:Physical Stimulation