Dicentric Y chromosome without evidence of mosaicism in an azoospermic male.
A phenotypically male of dicentric Y chromosome with no evidence of sex chromosomal mosaicism is reported. Staining of fluorescence in situ hybridization using Y chromosome centromere-specific DNA probe showed the presence of two bright fluorescent spots in Y chromosome. Testicular histology revealed maturation arrest at the stage of primary spermatocyte. It is suggested that structural anomaly of the Y chromosome is related to the disturbance of spermatogenesis.
Sasagawa
I
I
Department of Urology, Yamagata University, School of Medicine, Japan.
Ishigooka
M
M
Kato
T
T
Hayami
S
S
Hashimoto
T
T
Nakada
T
T
D000328:Adult; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D014998:Y Chromosome