[Changes in serum eosinophil cation protein level and blood eosinophil density in patients with asthma].
To study the functional state as well as the relation-ship between eosinophil and T lymphocyte in the asthmatics, the authors measured the eosinophil density of blood with percoll, the level of serum eosinophil cation protein (ECP) with radioimmunoassay and soluble IL-2 receptor (sIL-2R) concentration with ELISA. The results revealed that the proportion of hypodense eosinophil and the levels of serum ECP and sIL-2R were 36.3% +/- 14.80%, 10.74 +/- 7.22 mg/L and 0.33% +/- 10 U/L respectively in asthmatics, being significantly higher than those in normal subjects (14.71% +/- 8.20%, 6.93 +/- 4.91 mg/L, 0.13 +/- 0.03 U/L, respectively, P < 0.05 in all). There is remarkable correlation between any two of the three parameters (r = 0.40, 0.37, 0.39, respectively, P < 0.05). It is suggested that eosinophil activation is associated with T lymphocyte activation, both may be involved in the pathogenesis of asthma.
Wang
H
H
Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical College, Xian.
Sun
B
B
D000328:Adult; D001249:Asthma / Q000097:blood*; D001772:Blood Cell Count; D001798:Blood Proteins / Q000032:analysis*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000166:cytology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012260:Ribonucleases; D013601:T-Lymphocytes / Q000166:cytology
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D015375:Receptors, Interleukin-2; D012260:Ribonucleases