[The use of immunomodulators to enhance postvaccinal immunity to experimental poliomyelitis].
A possibility to use immunostimulator dibasole and methyluracil to increase [correction of decrease] the level of neutralising antibodies to polioviruses [correction of polyviruses] of types I, II, III in response to immunization by the alive poliomyelitis vaccine was studied in experiments on rabbits. The higher level of immune response when using the mentioned drugs, especially methyluracil, has been established; repeated immunization is needed to develop antibodies to poliovirus [correction of polyavirus] of type III.
Bondarenko
V I
VI
Zadorozhnaia
V I
VI
Buraia
T A
TA
Gritsenko
L N
LN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000187:drug effects; D001562:Benzimidazoles / Q000494:pharmacology*; D007109:Immunity / Q000187:drug effects; D007114:Immunization / Q000379:methods; D009500:Neutralization Tests; D011051:Poliomyelitis / Q000517:prevention & control*; D017955:Poliovirus / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000276:immunology*; D011817:Rabbits; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D014613:Vaccines, Attenuated / Q000276:immunology
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D001562:Benzimidazoles; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated; C004453:bendazole; D014498:Uracil; C008378:6-methyluracil
Ispol'zovanie immunomoduliatorov s tsel'iu povysheniia postvaktsinal'nogo immuniteta k poliomielitu v éksperimente.