Clonal chromosome abnormalities in two chemodectomas.
Short-term cultures from two histologically benign chemodectomas, one from the carotid body and one from the vagal nerve, were analyzed cytogenetically. The former had a small abnormal clone with the karyotype 46,XX,t(3;19)(q21;q13),t(12;15) (p13;q12-14), whereas the majority of the cells from the latter tumor displayed two related abnormal clones: 46,XY,i(I)(q10)/ 46,iderm,add(2)(q37). The findings add to the evidence that chemodectomas are heterogeneous neoplasms and suggest that the heterogeneity may possibly be associated with the site of origin.
Jin
Y
Y
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Mertens
F
F
Jin
C
C
Wennerberg
J
J
Mandahl
N
N
Heim
S
S
Mitelman
F
F
D002345:Carotid Body Tumor / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009380:Neoplasms, Nerve Tissue / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010236:Paraganglioma, Extra-Adrenal / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014407:Tumor Cells, Cultured; D014630:Vagus Nerve