Levels of cerium in the tissues of rats fed a magnesium-restricted and cerium-adulterated diet.
Cerium, a lanthanide, is the most abundant rare earth element present in monazite and is biologically active. It has been postulated that cerium toxicity in conjunction with magnesium deficiency causes tropical endomyocardial fibrosis, a restrictive human cardiomyopathy (Valiathan et al. 1989; Valiathan and Kartha 1990). Generally, lanthanides are known to be poorly absorbed (Durbin et al. 1956; Evans 1990). The present study was carried out to ascertain whether magnesium deficiency promotes accumulation of cerium in various organs of rats.
Eapen
J T
JT
Division of Cellular and Molecular Cardiology and Division of Materials Toxicology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Kartha
C C
CC
Rathinam
K
K
Valiathan
M S
MS
D000818:Animals; D001842:Bone and Bones / Q000737:chemistry / Q000378:metabolism; D002563:Cerium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D008274:Magnesium / Q000032:analysis; D008275:Magnesium Deficiency / Q000150:complications / Q000378:metabolism*; D008297:Male; D051381:Rats; D014018:Tissue Distribution
D002563:Cerium; D008274:Magnesium