Cytochalasin W, a new 24-oxa[14]cytochalasan from Phoma exigua var. heteromorpha.
A further cytochalasin was isolated from liquid culture filtrates of Phoma exigua var. heteromorpha together with cytochalasins U and V and other well-known cytochalasins. The metabolite, named cytochalasin W, was characterized by spectroscopic and chemical methods as a new 24-oxa[14]cytochalasan, bearing a formyl group on the macrocyclic ring. Cytochalasin W showed toxic activity in the brine shrimp assay.
Evidente
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Dipartimento di Scienze Chimico-Agrarie, Università di Napoli Federico II, Portici, Italy.
Capasso
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Vurro
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Bottalico
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D000818:Animals; D001156:Artemia / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003470:Culture Media; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism*; D018515:Plant Leaves / Q000378:metabolism; D012015:Reference Standards; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
D003470:Culture Media; D003572:Cytochalasins; C101561:cytochalasin W