Expression of p53 protein in tissues and organs of human and mouse embryo.
The expression of p53 was demonstrated in the cells of some tissues in the various stages of human embryo development. The distribution of this protein correlates in some cases with sites of higher proliferative activity as demonstrated by PCNA/cyclin detection. It is necessary to prove whether the p53 protein participates in the regulation of cell division, or it is the aberrant expression of unfunctional p53 which is induced in sites of higher proliferation by feed back regulatory mechanism.
Lichnovský
V
V
Institute of Histology and Embryology, Palacký University, Olomouc, Czech Republic.
Kamarád
V
V
Kolár
Z
Z
Vojtĕsek
B
B
D000818:Animals; D002455:Cell Division; D016213:Cyclins / Q000032:analysis; D004622:Embryo, Mammalian / Q000502:physiology*; D005314:Embryonic and Fetal Development; D005260:Female; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D051379:Mice; D009928:Organ Specificity; D011247:Pregnancy; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*
D016213:Cyclins; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53