Pharmacological characteristics of Sho-seiryu-to, an antiallergic Kampo medicine without effects on histamine H1 receptors and muscarinic cholinergic system in the brain.
The pharmacological characteristics of Sho-seiryu-to, an antiallergic Kampo medicine, were investigated. Forty-eight-hour passive cutaneous anaphylactic (PCA) reaction was significantly inhibited in rats orally administered Sho-seiryu-to (1000 mg/kg). Sho-seiryu-to significantly inhibited increase in vascular permeability induced by histamine. These data confirm previous findings that Sho-seiryu-to has antiallergic activity in animals and suggest that the antagonism of histamine may be an antiallergic mechanism of Sho-seiryu-to. Sho-seiryu-to did not affect locomotor activity or motor coordination in mice. Although ketotifen prolonged sleeping time induced by pentobarbital, Sho-seiryu-to had no such effect. Nor was there any effect on oxotremorine-induced tremor and [3H]-mepyramine binding to histamine H1 receptors in rat brain. Thus, Sho-seiryu-to appears to be useful for treating type I allergy, with relatively few side effects such as sedation and drowsiness due mainly to blockade of histamine H1 and muscarinic receptors in the brain.
Sakaguchi
M
M
Central Research Laboratories, Tsumura & Co., Ibaraki, Tokyo, Japan.
Iizuka
A
A
Yuzurihara
M
M
Ishige
A
A
Komatsu
Y
Y
Matsumiya
T
T
Takeda
H
H
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D018678:Cholinergic Agents; D003875:Drug Eruptions / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000378:metabolism; D007665:Ketotifen / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011738:Pyrilamine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D014202:Tremor / Q000139:chemically induced
D018926:Anti-Allergic Agents; D018678:Cholinergic Agents; D004365:Drugs, Chinese Herbal; D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; C090832:sho-seiryu-to; D010095:Oxotremorine; D011738:Pyrilamine; D007665:Ketotifen