title: Transgenic mice: models for the study of cataractogenesis. A minireview.
abstract: Genetic manipulation followed by (over)expression of the transgene product in lens tissue results in: (I) inhibition of denucleation of lens fibers; (II) interference with lens cell differentiation; (III) cataract formation. The events reviewed are preceded by membrane damage, perturbed assembly of the IF cytoskeleton and distortion of the cytoskeleton-membrane complex.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Bloemendal
authors.forename: E L
authors.initials: EL
authors.lastname: Benedetti
authors.forename: I
authors.initials: I
authors.lastname: Dunia
mesh_terms: D000818:Animals; D002386:Cataract / Q000209:etiology*; D003459:Crystallins / Q000235:genetics; D005796:Genes; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic
chemical_list: D003459:Crystallins