Effects of corticosteroid therapy in non-allergic rhinosinusitis.
Corticosteroids have a multifactorial effect initiated by their binding to a specific cytoplasmic glucocorticoid receptor. At the cellular level there is a reduction in the number of antigen-presenting cells, in the number and activation and T cells, in the number of epithelial mast cells, and in the number and activation of eosinophils. Steroids have a proven effect on symptoms and signs in non-allergic rhinosinusitis with eosinophilia and in nasal polyposis. Topically applied drugs, studied in many controlled trials, reduce rhinitis symptoms, improved nasal breathing, reduce the size of polyps and their recurrence, but have a poor effect on the sense of smell and no direct effect on sinus pathology. Systemic steroids, less well studied, appear to have an effect on all types of symptoms and pathology, the sense of smell included. A short course of systemic steroids is as effective as polypectomy with a snare. Individualized management of nasal polyposis and non-allergic rhinosinusitis with eosinophilia may consist of long-term topical steroids, short-term systemic steroids, or surgery, in various combinations.
Mygind
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Department of Otorhinolaryngology Rigshospitalet, Copenhagen, Denmark.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D015703:Antigens, CD / Q000187:drug effects; D001507:Beclomethasone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001623:Betamethasone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004804:Eosinophils / Q000187:drug effects; D006801:Humans; D009297:Nasal Mucosa / Q000187:drug effects; D009298:Nasal Polyps / Q000188:drug therapy; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D015703:Antigens, CD; D001623:Betamethasone; D001507:Beclomethasone