[pS2 protein and breast cancer].
pS2 is a small protein (7000 daltons) that is prevalently expressed in human breast cancer positive for estrogen receptors: protein is, in fact, induced by estrogen stimulation. Studies indicate that pS2 protein is a marker for hormone-dependent breast tumors and that its expression is helpful in the prognosis. The presence of pS2, in fact, besides being associated in 96% of the cases to the positivities for estrogen receptors, is associated with longer overall, and disease free, survival. The pS2 protein is also expressed in normal stomach mucosa; its physiological function is unknown.
Torre
E A
EA
Istituto Nazionale per la Ricerca sul Cancro, Genova.
Fulco
R A
RA
D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000032:analysis* / Q000502:physiology; D009376:Neoplasms, Hormone-Dependent; D011379:Prognosis; D011506:Proteins; D011863:Radioimmunoassay; D011959:Receptors, Estradiol / Q000032:analysis* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000032:analysis*; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D011506:Proteins; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
Proteina pS2 e carcinoma mammario.