[Some new perspectives on V. I. Deshcherevskiy's kinetic theory of muscle contraction].
Deshcherevsky's kinetic theory of muscle contraction (Deshcherevsky, 1968, 1971) is considered in the light of the modern experimental data. The data are discussed, which support the validity of some propositions and conclusions of the theory, including the postulate on the negligibly small probability of pulling cross-bridge detachment. It is shown that if this postulate is accepted and the distance between the neighbouring actin sites for the given myosin cross-bridge attachment on the actin filament is taken as an actin filament half-turn (Sydorenko, 1982, 1984), then simple explanations, which don't contradict the cross-bridge hypothesis of force generation, could be given to a number of muscle behaviour features such as the high efficiency, stepwise shortening, repeated tension recovery after repeated forced step-wise shortening of activated muscle with the time-interval less than 10 ms, step-size up to 90nm powered by a single ATP molecule and so on.
Sidorenko
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D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D008954:Models, Biological; D008956:Models, Chemical; D009119:Muscle Contraction; D009132:Muscles / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
D000255:Adenosine Triphosphate
Nekotorye novye vozmozhnosti kineticheskoĭ teorii myshechnogo sokrashcheniia V.I. Deshcherevskogo.