title: Advances in cancer research: report from the eighty-sixth annual meeting of the American Association for Cancer Research.
abstract: A meeting of the American Association for Cancer Research was held in Toronto, Canada on March 18-22, 1995 to discuss advances in cancer research. Growing interest was shown in the molecular mechanisms of prostate cancer. Both breast cancer and colorectal cancer continued to be major scientific topics of interest. Research into the genetics of cancer was dominated by the issue of genomic instability due to failures in the mismatch DNA repair gene system of cells. Instability appeared to represent the key mechanism for the generation of mutations. Another common theme was the identification of putative tumor suppressor and metastasis loci using loss of heterozygosity and cell chromosome fusion approaches. A few novel sequences with a potential suppressive function were reported. Also, relationships between growth factor receptors, tumor suppressor genes, oncogenes, and proteins controlling cell cycle were analyzed. Progress in gene therapy and chemoprevention of malignant tumors was frequently discussed.
authors.affiliation: Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA. Przemko-Waliszewski@uokhsc.edu
authors.forename: P
authors.initials: P
authors.lastname: Waliszewski
authors.forename: R E
authors.initials: RE
authors.lastname: Hurst
mesh_terms: D000570:American Cancer Society; D000818:Animals; D006801:Humans; D009369:Neoplasms