title: Immunoregulatory effects of indomethacin on rats with trauma.
abstract: In this article, we investigated changes of immune functions and immunoregulatory effects of indomethacin on rats with trauma. The results show that spontaneous suppressor T cell activity of spleen significantly increased and Interleukin I production and DNA synthesis capacity of splenocytes markedly decreased in rats with trauma. Indomethacin could markedly improve immune function, decreased spontaneous suppressor T cell activity and prompted Interleukin 2 production and DNA synthesis capacity of splenocytes.
authors.affiliation: Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan.
authors.forename: Y C
authors.initials: YC
authors.lastname: Pan
authors.forename: S X
authors.initials: SX
authors.lastname: Zhang
authors.forename: X Z
authors.initials: XZ
authors.lastname: Ding
authors.forename: H
authors.initials: H
authors.lastname: Li
mesh_terms: D000007:Abdominal Injuries / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D007213:Indomethacin / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D004247:DNA; D007213:Indomethacin