Chronotherapy for human solid tumors other than colorectal.
Available data regarding the application of chronobiological concepts to the medical treatment of various human solid tumors are reviewed. In the majority of reported trials, an improvement of therapeutic index has been observed with an increase in overall drug dose intensities, despite reduced overall toxicity and an excellent level of tumor response and survival. This assessment was obvious for ovarian, lung (non small cell), renal cell, pancreas, breast and upper aerodigestive tract carcinomas.
Focan
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Centre Hospitalier Saint-Joseph-Espérance, Liège, Belgium.
D000818:Animals; D001943:Breast Neoplasms / Q000628:therapy; D002292:Carcinoma, Renal Cell / Q000628:therapy; D002909:Chronobiology Phenomena; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy; D009369:Neoplasms / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000628:therapy