Insights on immunological aging derived from the T lymphocyte cellular senescence model.
A human T cell culture system has been developed to study cellular senescence in a manner analogous to that used for fibroblasts. Using this system, several markers of replicative senescence have been identified. Evidence is provided to show that new insights into the immune deficiency of aging as well as HIV infection have emerged from the in vitro model. The culture model is now being exploited to dissect the basic mechanisms underlying the senescence program in T cells.
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Department of Pathology, UCLA School of Medicine 90024-1732, USA.
D000818:Animals; D018106:CD28 Antigens / Q000032:analysis; D002478:Cells, Cultured; D016922:Cellular Senescence; D006801:Humans; D008954:Models, Biological; D013601:T-Lymphocytes / Q000502:physiology*
D018106:CD28 Antigens