title: Clozapine treatment of euphoric mania.
abstract: Four patients with treatment-resistant euphoric mania characterized by elevated mood, hyperactivity, and rapid speech, refractory to standard treatments and anticonvulsants, showed dramatic improvement in symptoms when treated with clozapine. All developed enhanced functioning and new insight into previous psychopathology. This degree of improvement suggests that clozapine can be considered in the treatment of not only schizophrenia, schizoaffective disorder, and dysphoric mania but also classic euphoric mania unresponsive to traditional treatments.
authors.affiliation: Department of Psychiatric Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Antonacci
authors.forename: C M
authors.initials: CM
authors.lastname: Swartz
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003024:Clozapine / Q000008:administration & dosage / Q000627:therapeutic use*; D005059:Euphoria / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine