title: [Energy-dependent processes and metabolism of adenylates in human erythrocytes].
abstract: Amphotericin B (1-3 mg/l) decreases the ATP content in erythrocytes by 11-26% and stimulates the K+ efflux but has no effect on the adenylate pool. Adenosine added to the erythrocyte suspension increases the adenylate pool, maintains a high intracellular ATP level for 6-8 hours of incubation at 37 degrees C and diminishes the amphotericin B-induced leakage of K+. Incubation of erythrocytes without glucose for 4-5 hours leads to a 20-50% loss of ATP accompanied by a significant reduction of the adenylate pool. Further addition of glucose partly restores the ATP level. In the presence of adenosine the ATP concentration is restored far more pronounced reaching nearly the original level due to the increase of the adenylate pool.
authors.affiliation: fazli@bioscience.msk.su
authors.forename: F I
authors.initials: FI
authors.lastname: Ataullakhanov
authors.forename: V M
authors.initials: VM
authors.lastname: Vitvitskiĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Komarova
authors.forename: E V
authors.initials: EV
authors.lastname: Mosharov
mesh_terms: D000227:Adenine Nucleotides / Q000096:biosynthesis / Q000097:blood*; D000241:Adenosine / Q000378:metabolism / Q000494:pharmacology; D000666:Amphotericin B / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D004734:Energy Metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D017136:Ion Transport
chemical_list: D000227:Adenine Nucleotides; D000900:Anti-Bacterial Agents; D000666:Amphotericin B; D000241:Adenosine
vernacular_title: Energozavisimye protsessy i metabolizm adenilatov v éritrotsitakh cheloveka.