title: Nitric oxide synthase-containing neurons in the hippocampus are preserved in trimethyltin intoxication.
abstract: We studied the effects of trimethyltin (TMT) (9 mg/kg, p.o.) on the nitric oxide synthase (NOS)-containing neurons in the rat hippocampus by NADPH-diaphorase histochemistry and a biochemical assay of NOS activity. TMT exposure caused the typical behavioral changes and a loss of the CA3/4 pyramidal cells, which were NADPH diaphorase-negative. The scattered interneurons and the CA1 pyramidal cells, which were NADPH diaphorase-positive, were spared. Hippocampal NOS activity showed no reduction in the TMT-treated rats compared with the controls. These results provide evidence of the preservation of the NOS-containing neurons in TMT intoxication.
authors.affiliation: Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan. ikeda.cell@dent.tmd.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Kanai
authors.forename: M
authors.initials: M
authors.lastname: Akaike
authors.forename: S
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: M
authors.initials: M
authors.lastname: Sadamatsu
authors.forename: A
authors.initials: A
authors.lastname: Masui
authors.forename: N
authors.initials: N
authors.lastname: Kato
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D006651:Histocytochemistry; D007395:Interneurons / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009252:NADPH Dehydrogenase / Q000032:analysis*; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000032:analysis*; D017966:Pyramidal Cells / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014298:Trimethyltin Compounds / Q000506:poisoning*
chemical_list: D014298:Trimethyltin Compounds; C046488:trimethyltin; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase