Didanosine measurement by radioimmunoassay.
Didanosine is commonly prescribed as monotherapy or as part of a combination regimen for patients with human immunodeficiency virus infection. The use of lower doses, either as part of a combination regimen or as a result of dose reduction secondary to clinical intolerance, requires that a sensitive assay method be available for either traditional or population-based pharmacokinetic evaluations. We evaluated a radioimmunoassay technique with a standard curve range of 0 to 100 ng/ml in human plasma, urine, and cerebrospinal fluid and assessed its accuracy and precision for use in pharmacokinetic studies.
DeRemer
M
M
Department of Pharmacy Practice, State University of New York at Buffalo, USA.
D'Ambrosio
R
R
Morse
G D
GD
D000998:Antiviral Agents / Q000032:analysis* / Q000493:pharmacokinetics; D016049:Didanosine / Q000032:analysis* / Q000493:pharmacokinetics; D006801:Humans; D011863:Radioimmunoassay / Q000379:methods*
D000998:Antiviral Agents; D016049:Didanosine