Immunoregulatory effects of indomethacin on rats with trauma.
In this article, we investigated changes of immune functions and immunoregulatory effects of indomethacin on rats with trauma. The results show that spontaneous suppressor T cell activity of spleen significantly increased and Interleukin I production and DNA synthesis capacity of splenocytes markedly decreased in rats with trauma. Indomethacin could markedly improve immune function, decreased spontaneous suppressor T cell activity and prompted Interleukin 2 production and DNA synthesis capacity of splenocytes.
Pan
Y C
YC
Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan.
Zhang
S X
SX
Ding
X Z
XZ
Li
H
H
D000007:Abdominal Injuries / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D007213:Indomethacin / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D004247:DNA; D007213:Indomethacin