Study on in vivo release of levonorgestrel-containing silicon capsule.
The in vivo release rate of levonorgestrel-containing silicon capsule (in vitro releasing rate: 6 micrograms/d) placed in rabbits was determined. The results showed that the average release per year was 8.32 micrograms with r being 0.96000. The release pattern of the levonorgestrel-containing silicon capsule system was proved to be zero-order release. Our study provided some experimental data for clinical use of the system for birth control.
Wu
C J
CJ
Birth Control Institution, Tongji Medical University, Wuhan.
Wu
X R
XR
Xia
W J
WJ
Li
R L
RL
D000818:Animals; D002214:Capsules; D005260:Female; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel; D011817:Rabbits; D012826:Silicone Elastomers
D002214:Capsules; D012826:Silicone Elastomers; D016912:Levonorgestrel