title: Serotonin indices and impulsivity in normal volunteers.
abstract: Hormonal responses to oral paroxetine were examined in a group of healthy subjects. The calcium response to serotonin (5-hydroxytryptamine, 5HT), mediated by platelet 5HT2A, was also measured. Paroxetine elicited a cortisol response that was directly correlated with the magnitude of platelet calcium response. The cortisol response was also correlated with the trait of impulsivity. These results suggest that paroxetine may be a useful probe in studies of serotonergic systems.
authors.affiliation: Department of Psychiatry, Long Beach Veterans Affairs Medical Center, CA 90822, USA.
authors.forename: C
authors.initials: C
authors.lastname: Reist
authors.forename: D
authors.initials: D
authors.lastname: Helmeste
authors.forename: L
authors.initials: L
authors.lastname: Albers
authors.forename: H
authors.initials: H
authors.lastname: Chhay
authors.forename: S W
authors.initials: SW
authors.lastname: Tang
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007175:Impulsive Behavior / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D017374:Paroxetine; D010555:Personality Inventory; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors; D016037:Single-Blind Method
chemical_list: D002118:Calcium; D006854:Hydrocortisone; D017374:Paroxetine; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors