title: An acardiac acephalic monster following in-utero anti-epileptic drug exposure.
abstract: Acardia, the absence of the heart, is one of the rarest medical anomalies. The exact mechanism which causes this anomaly is still unknown. The authors report the acardiac acephalic fetus of an epileptic mother who was on primidone therapy. The mother who received no antenatal care stopped taking primidone (her sole medication) in the third month of pregnancy with the fear of delivering a malformed baby and had three convulsions until delivery. This is the first reported case of acardia associated with anti-epileptic medication. The cause of the anomaly in this patient may be an unknown genetic defect, the maternal epileptic disorder, the convulsions, the anti-epileptic medication, or a combination of these factors.
authors.affiliation: Zübeyde Hanim Maternity Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Kutlay
authors.forename: S
authors.initials: S
authors.lastname: Bayramoglu
authors.forename: A I
authors.initials: AI
authors.lastname: Kutlar
authors.forename: N
authors.initials: N
authors.lastname: Yesildaglar
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced*; D009008:Abnormalities, Severe Teratoid / Q000139:chemically induced*; D000328:Adult; D000757:Anencephaly / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006801:Humans; D011247:Pregnancy; D011324:Primidone / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants; D011324:Primidone