[Lipid vehicles for the parenteral administration of drugs (1): emulsions].
To increase the efficiency of medication used in therapy and diagnostics, there have been, during the last decades, important advances in the inclusion techniques hereof, in vehicles which give greater selectivity and tolerance. Among the colloidal vehicle systems of medications with different medications, the object of the present review study. Therefore, we analyze the rationale of their use as a vehicle of medication, their physical and chemical characteristics, the ways of elimination after their administration, as well as the formulations in oil-water emulsions for the parenteral administration of diferent active substances such as diazepam, propofol, methohexital, ethomidate, amphotericin B, cytostatics, and cyclosporine, among others. The results of published studies on the efficiency and therapeutic applications of these are presented.
Bermejo Vicedo
T
T
Servicio de Farmacia, Hospital Severo Ochoa, Leganés, Madrid, España.
Hidalgo Correas
F J
FJ
Carrasco
J M
JM
D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003975:Diazepam / Q000008:administration & dosage; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007263:Infusions, Parenteral; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage / Q000737:chemistry*; D015742:Propofol / Q000008:administration & dosage
D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D004655:Emulsions; D005079:Excipients; D006993:Hypnotics and Sedatives; D014677:Pharmaceutical Vehicles; D000666:Amphotericin B; D003975:Diazepam; D015742:Propofol
Vehículos lipídicos para la administración parenteral de medicamentos (1. parte): emulsiones.