title: [Effects of allopurinol on damage caused by ischemia and reperfusion of skeletal muscles: an in vivo spectroscopic analysis (31P-MR) in rats].
abstract: The effect of allopurinol on energetic metabolism (reutilization of hypoxanthine) has been studied in vivo by mean of 31P-RM spectroscopy on skeletal muscle in the rat in conditions of ischemia and reperfusion. The treatment with allopurinol demonstrates of on benefit or phosphocreatine and ATP kinetics. These results outline that reutilization of hypoxanthine doesn't represent a protective mechanism of allopurinol on skeletal muscles. The role of hypoxanthine reutilization has to be investigated with further researches.
authors.affiliation: Reparto di chirurgia, Ospedale Civico, Lugano.
authors.forename: L
authors.initials: L
authors.lastname: Gürke
authors.forename: P M
authors.initials: PM
authors.lastname: Sutter
authors.forename: A
authors.initials: A
authors.lastname: Kuhrmeier
authors.forename: P
authors.initials: P
authors.lastname: Erhard
authors.forename: S
authors.initials: S
authors.lastname: Martinoli
authors.forename: M
authors.initials: M
authors.lastname: Heberer
mesh_terms: D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009132:Muscles / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
chemical_list: D000963:Antimetabolites; D004791:Enzyme Inhibitors; D000493:Allopurinol
vernacular_title: Effetto dell'allopurinolo sui danni causati da ischemia e riperfusione nella muscolatura scheletrica: un'analisi spettroscopica (31P-RM) in vivo nel ratto.