title: Comparative in-vitro activity of SCH 27899, a novel everninomicin, and vancomycin.
abstract: The antibacterial activity of SCH 27899, was compared with vancomycin in vitro against 210 recent clinical isolates representing eight major genera of Gram-positive organisms. MIC90 values for everninomicin were consistently better than those of vancomycin for all Gram-positive bacteria tested. Although everninomicin was less bactericidal than vancomycin against staphylococci, it was inhibitory against vancomycin-resistant enterococci. This novel antibiotic may, therefore, provide a clinical alternative to penicillin and vancomycin for therapy of Gram-positive infections.
authors.affiliation: Department of Medicine, New York Hospital, Medical Center of Queens, Flushing 11355-5095, USA.
authors.forename: C
authors.initials: C
authors.lastname: Urban
authors.forename: N
authors.initials: N
authors.lastname: Mariano
authors.forename: K
authors.initials: K
authors.lastname: Mosinka-Snipas
authors.forename: C
authors.initials: C
authors.lastname: Wadee
authors.forename: T
authors.initials: T
authors.lastname: Chahrour
authors.forename: J J
authors.initials: JJ
authors.lastname: Rahal
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C001202:evernimicin; D014640:Vancomycin