Dynamics of fever and the cytokine network in systemic juvenile arthritis.
OBJECTIVE
To determine the levels of the inflammatory cytokines IL1 alpha, IL1 beta, TNF alpha, IL6, IL8 and of their inhibitors TNF-sR55, TNF-s R75 and IL1-Ra during temperature elevation in systemic juvenile chronic arthritis.


METHODS
Fifty-six serum samples were collected at regular intervals from seven children during 8 fever cycles. Cytokine levels were determined using enzyme-linked immunoassays.


RESULTS
Levels of IL1 alpha, IL1 beta, TNF alpha and IL8 showed no variations. In contrast, IL6 and IL1-Ra levels paralleled the fever spikes. TNF-sR75 levels were also correlated with the fever.


CONCLUSIONS
Fever dynamics in systemic juvenile chronic arthritis may be partly related to cytokine variations.
Prieur
A M
AM
Pediatric Rheumatology Department, Enfants-Malades Teaching Hospital, Paris, France.
Roux-Lombard
P
P
Dayer
J M
JM
D001171:Arthritis, Juvenile / Q000097:blood / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005334:Fever / Q000503:physiopathology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha