Genetics of intracisternal-A-particle-related envelope-encoding proviral elements in mice.
Intracisternal-A-particle-related envelope-encoding (IAPE) proviral elements in the mouse genome encode and express an envelope-like protein that may allow transmission of IAPEs as infectious agents. To test IAPE mobility and potential transmission in mice, we have analyzed the distribution of IAPE elements in the genomes of Mus spretus and Mus musculus inbred strains and wild-caught animals. Potential full-length (IAPE-A) proviral elements are present as repetitive copies in DNA from male but not female animals of M. musculus inbred strains and Mus musculus castaneus. Analysis of IAPE-cellular junction fragments indicates that fixation of most IAPEs in the germ line occurred in M. musculus and M. spretus after speciation but before M. musculus inbred strains were derived.
Reuss
F U
FU
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Frankel
W N
WN
Moriwaki
K
K
Shiroishi
T
T
Coffin
J M
JM
D000818:Animals; D001208:Asia; D001483:Base Sequence; D005075:Biological Evolution; D005060:Europe; D005260:Female; D015686:Gene Products, env / Q000096:biosynthesis*; D007426:Genes, Intracisternal A-Particle; D015752:Genes, env; D016678:Genome; D008099:Liver / Q000821:virology; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics*; D009838:Oligodeoxyribonucleotides; D011533:Proviruses / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012727:Sex Characteristics; D013045:Species Specificity
D015686:Gene Products, env; D009838:Oligodeoxyribonucleotides