[Hypoplastic mixed lineage leukemia successfully treated with low-dose cytosine arabinoside].
A 54-year-old male was admitted because of dyspnea on exercise. His peripheral blood revealed pancytopenia with severely hypoplastic bone marrow. Bone marrow aspiration showed a marked hypocellular marrow with 62.4% of blast cells. Cytochemical studies showed that peroxidase activity, alpha-nephtyl buthylate esterase activity and PAS reaction were negative, and that only ASD-chroloacetate esterase activity was positive. Surface marker analysis of blast cells showed positive result for CD5, 7, 33 and 34 antigens. The T-cell receptor beta gene was rearranged, but the immunoglobulin H chain gene showed a germ line configuration. Terminal Deoxynucleotydyl Transferase (TdT) was positive, but cellular surface and cytoplasmic immunoglobulin were not recognized. A diagnosis of hypoplastic mixed lineage leukemia was made and treated with low dose cytosine arabinoside, he resulted in complete remission. The relation between hypoplastic leukemia, AML-M0 and mixed lineage leukemia was also discussed.
Sasaki
S
S
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Ueda
S
S
Asakura
Y
Y
Yamazaki
E
E
Kato
K
K
Taguchi
J
J
Harano
H
H
Kanamori
H
H
Ogawa
K
K
Otsuka
M
M
Matuszaki
M
M
Mohri
H
H
Okubo
T
T
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003561:Cytarabine / Q000008:administration & dosage*; D006801:Humans; D015456:Leukemia, Biphenotypic, Acute / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine