title: Dehydroepiandrosterone and insulinaemia.
abstract: Low dehydroepiandrosterone (DHEA) and hyperinsulinaemia are assumed to be risk factors of atherosclerosis. Exogenous hyperinsulinaemia during hyperinsulinaemic clamp decreases DHEA. We have evaluated interaction of these hormones during 2 weeks of therapeutic starvation in 11 obese patients (mean BMI 41.2 kg/m2), 5 nondiabetics and 6 diabetics with diet only therapy. Comparing diabetics with normals we have found no differences in BMI and blood DHEA, DHEAS and insulin levels. We have found a light implication of negative correlation of insulin to DHEA and DHEAS level in diabetics (r = -0.71, -0.73, p = 0.16, 0.18). During starvation insulinaemia is declining, DHEA initial increase is followed by a decrease (r = 0.93, p = 0.01). We conclude that insulin decrease during starvation could be a cause of DHEA decrease. This finding is unexpected according to the potential of exogenous insulin to suppress DHEA. Further investigation of endogenous DHEA and insulin relation is necessary.
authors.affiliation: IIIrd Dept. of Internal Medicine, 1st Medical Faculty, Charles Universtiy, Prague, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Svacina
authors.forename: J
authors.initials: J
authors.lastname: Sonka
authors.forename: T
authors.initials: T
authors.lastname: Haas
mesh_terms: D001161:Arteriosclerosis / Q000097:blood*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood / Q000172:deficiency*; D019314:Dehydroepiandrosterone Sulfate; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D009765:Obesity / Q000097:blood; D012307:Risk Factors
chemical_list: D007328:Insulin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate