title: [A case of eosinophilic fasciitis with excessive increase of muscle enzyme].
abstract: A sixty-year old woman had muscle pain of her extremities and stiffness in her fingers after unusual physical exertion. On admission she developed indurative swellings of the upper extremities and flexion contractures of her fingers. Laboratory data showed peripheral blood eosinophilia and excessive increase of muscle enzymes. Electromyography showed a myopathic pattern and magnetic resonance imaging showed findings of myositis. We performed a full thickness biopsy from skin to muscle. In histopathologic studies, collagenous hypertrophy of the fascia and perifascicular atrophy of muscle fibers and infiltrates on eosinophiles in the interstitial tissue were found. She was treated with prednisolone (60 mg/day). Clinical symptoms showed improvement and her peripheral blood eosinophiles and serum muscle enzymes deminished quickly. In this case, we suggest that the characteristic histopathologic findings in eosinophilic faciitis is not fascia alone, but includes muscle. We stress that eosinophilic faciitis and polymyositis are closely related.
authors.affiliation: Department of internal medicine, Kitami Red Cross Hospital, Hokkaido, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: I
authors.initials: I
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Taneichi
authors.forename: H
authors.initials: H
authors.lastname: Shibaki
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D004802:Eosinophilia / Q000188:drug therapy / Q000201:enzymology*; D005208:Fasciitis / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology*; D017285:Polymyositis; D011239:Prednisolone / Q000008:administration & dosage
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone