title: [Effect of the nature of the heteroatom of a monosaccharide derivative on its inhibitory action in relation to P-type calcium channels expressed in the Xenopus oocyte].
abstract: Our results demonstrate that saccharidic derivatives obtained by adding a C8 alkyl group through various heteroatomes (O, N or S) to a monoacetonide residue possess an inhibitory effect towards putative P-type calcium channels expressed in Xenopus oocytes. These derivatives partially and reversibly inhibit the activity these channels without changing their electrophysiological properties. Nevertheless, the derivative containing the heteroatome N also affects the fast and tetrodotoxin-sensitive sodium channel activity. Thus, only ether and thioether compounds (heteroatome O or S) can be selected for their inhibitory effect on P-type apparented calcium channels.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire, Université de Picardie Jules Verne, Amiens, France.
authors.forename: A
authors.initials: A
authors.lastname: Lahyani
authors.forename: F
authors.initials: F
authors.lastname: Matifat
authors.forename: T
authors.initials: T
authors.lastname: Collin
authors.forename: M
authors.initials: M
authors.lastname: Idaomar
authors.forename: D
authors.initials: D
authors.lastname: Postel
authors.forename: G
authors.initials: G
authors.lastname: Ronco
authors.forename: P
authors.initials: P
authors.lastname: Villa
authors.lastname: Brûlé
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry / Q000494:pharmacology*; D009584:Nitrogen / Q000737:chemistry*; D009865:Oocytes / Q000187:drug effects*; D010100:Oxygen / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry*; D009626:Terminology as Topic; D014981:Xenopus
chemical_list: D002121:Calcium Channel Blockers; D009005:Monosaccharides; D013455:Sulfur; D009584:Nitrogen; D010100:Oxygen
vernacular_title: Influence de la nature de l'hétéroatome d'un dérivé monosaccharidique sur son action inhibitrice vis à vis de canaux calciques apparentés au type P exprimés dans l'ovocyte de Xenopus.