Immunohistochemical and electrophysiological demonstration of substance P in human vestibular ganglion cells.
This study was performed in order to determine the immunohistochemical expression and distribution pattern as well as the electrophysiological actions of substance P in human vestibular ganglion cells. Substance P-like immunostaining was mainly found in the cytoplasm of small vestibular ganglion cells. In contrast, nerve fibers were not labeled. Using intracellular recording techniques, substance P produced a slow depolarization of membrane potentials accompanied by an increase in membrane resistance. Furthermore, an enhanced firing response to depolarization occurred.
Felix
H
H
ENT-Department, University Hospital of Zürich, Switzerland.
Schickinger
B
B
Felix
D
D
D018929:Cell Culture Techniques; D006801:Humans; D007150:Immunohistochemistry; D013373:Substance P / Q000032:analysis*; D014725:Vestibular Nerve / Q000737:chemistry*
D013373:Substance P