title: Acute treatment response in outpatients with panic disorder: high versus low depressive symptoms.
abstract: The authors studied 75 outpatients with DSM-III-R panic disorder who had participated in a clinical trial and had been randomly assigned to receive fluvoxamine, cognitive therapy, or placebo for an 8-week period. They compared a group with high levels of depressive symptoms and a group with low levels of depressive symptoms. At baseline, patients with high levels of depressive symptoms were more likely to have severe phobic avoidance and to have higher scores on measures of anxiety, hyochondriasis, and disability. An important finding was that depressive symptoms improved at a rate which paralleled improvement in panic and anxiety. Likewise, the presence of depressive symptoms did not interfere with treatment response in panic disorder. Clinical implications of the findings are discussed.
authors.affiliation: Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Black
authors.forename: R
authors.initials: R
authors.lastname: Wesner
authors.forename: W
authors.initials: W
authors.lastname: Bowers
authors.forename: P
authors.initials: P
authors.lastname: Monahan
authors.forename: J
authors.initials: J
authors.lastname: Gabel
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000175:diagnosis; D004311:Double-Blind Method; D005260:Female; D016666:Fluvoxamine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy*; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D010919:Placebos; D016666:Fluvoxamine