Immunochemical characterization of the cryoglobulins: pathophysiologic implications.
Immunochemical study of the cryoglobulins has produced a classification of three main types which present clinical correlates. With the current standard immunofixation technique the vast majority of cryoglobulins are presently classified as type II. High-resolution immunoelectrophoretic techniques (immunoblotting and two-dimensional polyacrylamide gel electrophoresis) have helped to identify new sub-types whose clinical relevance is as yet undetermined. Nevertheless, these sensitive techniques could contribute to elucidate the various stages in the natural history of HCV-related cryoglobulins, from possible earlier HCV-antigen-driven polyclonal B cell proliferation, to autonomous monoclonal benign, to malignant B cell proliferation.
Merlini
G
G
Medicina Interna ed Oncologia Medica, Università di Pavia, IRCCS Policlinico S. Matteo, Italy.
Zorzoli
I
I
Anesi
E
E
Perfetti
V
V
Marinone
G
G
D003450:Cryoglobulins / Q000737:chemistry / Q000145:classification*; D006801:Humans
D003450:Cryoglobulins