title: Understanding signal transduction during bacterial infection.
abstract: Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
authors.affiliation: Dept of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Akerley
authors.forename: J F
authors.initials: JF
authors.lastname: Miller
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D001885:Bordetella Infections / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; C065601:BvgA protein, Bacteria; D014157:Transcription Factors; C080662:bvgS protein, Bordetella pertussis