[The excitatory effect of NMDA-receptor antagonists: a comparison of preparations and different forms of movements].
Fourteen indices of spontaneous movement activity of mail NIH-Swiss mice were measured. All examined non-concurrent antagonists of NMDA receptors were found to stimulate locomotion and inhibit (or not change) the vertical activity component. Karbamazepin and diphenylgidantoin closed to them by structure and effect stimulated locomotion and rearings. Concurrent CPP antagonist and endogenous antagonist of receptor glycine sub-unit, kinurenic acid slightly inhibited locomotion. Phencyclidin and disocilpin induced stereotypy. Supposedly, increasing dopaminergic postsynaptic excitation forms the basis of stimulating effect.
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D018709:Statistics, Nonparametric; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
D016194:Receptors, N-Methyl-D-Aspartate
Vozbuzhdaiushchiĭ éffekt antagonistov NMDA retseptorov: sravnenie preparatov i raznykh form dvizheniĭ.