title: Gene conversion as a focusing mechanism for correlated mutations: a hypothesis.
abstract: Ways of producing complex mutational events without substantially raising the primary mutation rate are explored. If the small amount of DNA that is resynthesised through the action of the mismatch DNA repair system is not subject to further repair, the incidence of double mutations can increase by a factor of 100, while single mutations would increase by only 30%. Such a boost in the incidence of double mutations seems insufficient to meet the needs of higher organisms. For them, an alternative strategy would be to produce complex events by a succession of single mutations occurring in a correlated manner over several sexual generations. It is proposed that gene conversion may fulfill this role. Assuming that the resynthesis of DNA that occurs during gene conversion produces mutations in the conversion tract, one predicts a tendency for close mutations in corresponding sequences in the two homologous chromosomes, to promote, during conversion, further mutations in their vicinity. Semiquantitative calculations suggest that such a mechanism can be quite effective, provided the divergence between two paired chromosomes is around 10(-4) or less. Such a mechanism might constitute an adaptive mutation strategy acting at the population level.
authors.affiliation: Laboratoire de Physique Statistique, Ecole Normale Superieure, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Ninio
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics; D004260:DNA Repair; D005785:Gene Conversion / Q000235:genetics*; D008957:Models, Genetic; D016296:Mutagenesis / Q000235:genetics*; D009692:Nucleic Acid Heteroduplexes / Q000235:genetics
chemical_list: D009692:Nucleic Acid Heteroduplexes; D004247:DNA