Experimental intraperitoneal administration of cisplatin-activated carbon for rat ovarian adenocarcinomas.
Selective delivery of a high level of cisplatin (CDDP) to the omentum, intraperitoneal disseminated tumors and lymph nodes was studied using a dosage form of CDDP-activated carbon. Although intraperitoneal CDDP-activated carbon delivered much higher levels of CDDP to the omentum, tumors and lymph nodes, a primary burst phenomenon of CDDP occurred just after administration. This indicates that activated carbon is an unsuitable particle to provide a slow steady release of CDDP.
Sugiyama
T
T
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Japan.
Nishida
T
T
Kumagai
S
S
Ushijima
K
K
Shinagawa
A
A
Okina
H
H
Tomioka
Y
Y
Kataoka
A
A
Yakushiji
M
M
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002244:Carbon; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D007274:Injections, Intraperitoneal; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D051381:Rats
D000970:Antineoplastic Agents; D002244:Carbon; D002945:Cisplatin