Anticlastogenicity of vitamin C in vivo against the cytogenetic toxicity of muriate of potash in murine bone marrow cells.
The potential in vivo anticlastogenicity of vitamin C was evaluated in murine bone marrow cells against the cytogenetic toxicity of muriate of potash, a synthetic fertilizer. The animals were treated orally once daily for 7 days with muriate of potash (5g/kg) and/or vitamin C (10mg/kg). Metaphase chromosome analyses revealed that muriate of potash induced chromosomal abnormalities were significantly decreased, though still remained higher to control, when vitamin C was administered concurrently. The possible role of vitamin C in mitigating the muriate of potash induced cytogenetic toxicity is discussed.
Sinha
A K
AK
Department of Zoology, Bhagalpur University, India.
Khan
P K
PK
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002875:Chromosomes / Q000187:drug effects; D005260:Female; D005308:Fertilizers; D006878:Hydroxides / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051379:Mice; D017680:Potassium Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity
D016587:Antimutagenic Agents; D005308:Fertilizers; D006878:Hydroxides; D017680:Potassium Compounds; D001205:Ascorbic Acid; C029943:potassium hydroxide