title: Cytomegalovirus infection and colonic perforation in renal transplant patients.
abstract: Cytomegalovirus (CMV) infection in immunocompromised patients is a major cause of morbidity and mortality. A well-documented manifestation of gastrointestinal CMV infection is gastrointestinal haemorrhage. In contrast, CMV-associated intestinal perforation has rarely been reported after transplantation, although it is well documented in AIDS patients. Three patients are reported who received their first cadaveric renal transplant in 1994 and subsequently developed CMV disease. During the course of their CMV illness, which was treated with ganciclovir, each presented with clinical suspicion of peritonitis and proceeded to laparotomy. All three were found to have sigmoid colon perforations with histological evidence of CMV infection. Following bowel resection and defunctioning, two patients made an uneventful recovery and have had the continuity of their bowel restored, but one died of overwhelming sepsis within hours of surgery. The explanation for the apparent clustering of this rare condition in transplant patients is uncertain.
authors.affiliation: Oxford Transplant Centre, Headington, Oxford, UK.
authors.forename: G J
authors.initials: GJ
authors.lastname: Toogood
authors.forename: P H
authors.initials: PH
authors.lastname: Gillespie
authors.forename: S
authors.initials: S
authors.lastname: Gujral
authors.forename: B F
authors.initials: BF
authors.lastname: Warren
authors.forename: J A
authors.initials: JA
authors.lastname: Roake
authors.forename: D W
authors.initials: DW
authors.lastname: Gray
authors.forename: P J
authors.initials: PJ
authors.lastname: Morris
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D003125:Colostomy; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007416:Intestinal Perforation / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D015774:Ganciclovir