Fate of dipropyl sulphone in rat.
1. Dipropyl [35S]-sulphone was administered by gavage (4.24 mmol/4 ml/kg body weight) to the adult male Wistar rat following an overnight fast. 2. Urine was the major route of excretion (83%) with more radioactivity appearing during the second day (47%) than the first (28%). Only small amounts were found in the faeces (10%). Biliary excretion played an important role with substantial amounts of the dose (33%) passing through the bile duct during 0-48 h. A near total recovery was achieved suggesting that only small amounts (2%) may have been lost as volatile components. 3. Metabolism was limited, the majority (> or = 98%) of the sulphone being recovered unchanged. Oxidation of the sulphur with the formation of inorganic sulphate was the only pathway observed.
Nickson
R M
RM
Department of Pharmacology and Toxicology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
Mitchell
S C
SC
Zhang
A Q
AQ
D000818:Animals; D001659:Biliary Tract / Q000378:metabolism; D008297:Male; D011837:Radiation-Protective Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013450:Sulfones / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D013462:Sulfur Radioisotopes
D011837:Radiation-Protective Agents; D013450:Sulfones; D013462:Sulfur Radioisotopes; C099075:dipropyl sulfone