[Computed sonography observation on the effects of cimetidine on the liver blood flow in cirrhotic patients with portal hypertension].
The effects of cimetidine on the hepatic and portal vein blood flow were investigated in 20 cirrhotic patients with portal hypertension by computed sonography. Cimetidine given intravenously at a dose of 0.4g significantly increased the hepatic vein blood flow (60.2% +/- 63.6%, P < 0.01), at the same time its calculated cross section area increased by 40.2% +/- 81.3% (P < 0.01). The portal vein blood flow increased by 53.2% +/- 52.3% (P < 0.01). While its cross section area was 16.8% +/- 17.3% (P < 0.01). These results showed that the histamine H2-receptor antagonist cimetidine may dilate liver vascular bed and reduce portal blood flow resistance in cirrhotic patients with portal hypertension.
Li
S
S
People's Hospital, Beijing Medical University.
Hou
H
H
Leng
X
X
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D005260:Female; D006503:Hepatic Veins / Q000187:drug effects / Q000473:pathology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008102:Liver Circulation / Q000187:drug effects*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000187:drug effects / Q000473:pathology; D018615:Ultrasonography, Doppler, Color
D006635:Histamine H2 Antagonists; D002927:Cimetidine