Developing and shedding inhibitions: how MHC class II molecules reach maturity.
Over the past year, several important advances have been made in understanding the mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside antigen-presenting cells. Recent progress in the study of class II antigen presentation includes the identification of ligands from which invariant chain protects class II molecules in pre-endosomal compartments, an improved understanding of how invariant chain inhibits antigenic peptide binding, and the appreciation that HLA-DM (a factor important for antigen presentation in vivo) can act as a catalyst for peptide exchange.
Busch
R
R
Joseph Stokes Jr Research Institute, Children's Hospital of Philadelphia, PA 19104, USA.
Mellins
E D
ED
D017951:Antigen Presentation; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D011992:Endosomes / Q000276:immunology / Q000378:metabolism; D006681:HLA-D Antigens / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D018448:Models, Immunological; D011485:Protein Binding
D000944:Antigens, Differentiation, B-Lymphocyte; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II; D008024:Ligands; C045084:invariant chain