title: Endemic mycosis complicating human immunodeficiency virus infection.
abstract: Persons infected with the human immunodeficiency virus are prone to the development of many fungal diseases. Normal hosts with intact immunity usually recover from infection by these less-invasive fungi. In persons with compromised T-cell-mediated immunity, however, widespread dissemination from a pulmonary focus occurs. In this review, we discuss the epidemiology, clinical manifestations, diagnosis, and treatment of the three major North American mycoses, histoplasmosis, blastomycosis, and coccidioidomycosis. In most cases, amphotericin B is the initial drug of choice, followed by one of the azoles for lifelong maintenance therapy.
authors.affiliation: Santa Clara Valley Medical Center, San Jose, California, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Sarosi
authors.forename: S F
authors.initials: SF
authors.lastname: DAvies
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D000935:Antifungal Agents / Q000627:therapeutic use; D001759:Blastomycosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D003047:Coccidioidomycosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D015497:HIV-1; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000935:Antifungal Agents