Efficacy of 2-month total parenteral nutrition in AIDS patients: a controlled randomized prospective trial. The French Multicenter Total Parenteral Nutrition Cooperative Group Study.
OBJECTIVE
To evaluate the efficacy of total parenteral nutrition in AIDS patients.


METHODS
A prospective, randomized, controlled, multicentre trial.


METHODS
Over a period of 2 months, 31 malnourished and severely immunodepressed AIDS patients were assigned to receive either dietary counselling (n = 15) or home total parenteral nutrition (TPN; n = 16) via a central venous access after an educational program. Results were analysed by intent-to-treat basis.


RESULTS
Bodyweight change was +8 kg (+13 +/- 3%) in the TPN group and -3 kg (-6 +/- 2%) in the control group (P < 0.0006). Lean body mass increased in the TPN group (+9 +/- 3%) and decreased in the control group (-5 +/- 3%; P < 0.004) while body cell mass increased in the former (+15 +/- 4%) and decreased in the latter (-12 +/- 6%; P < 0.002). Nutritional subjective global assessment, subjective self-reported health feeling and Karnofsky index were also improved by TPN. Infection line sepsis incidence remained low (0.26 per 100 patient-days). However, no difference in survival rate was exhibited between the two groups by the log-rank test.


CONCLUSIONS
We conclude that home TPN is an efficient treatment of malnutrition in severely immunodepressed AIDS patients.
Melchior
J C
JC
Department of Nutrition, Bichat-Claude Bernard Hospital, Paris, France.
Chastang
C
C
Gelas
P
P
Carbonnel
F
F
Zazzo
J F
JF
Boulier
A
A
Cosnes
J
J
Boulétreau
P
P
Messing
B
B
D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality / Q000628:therapy*; D000328:Adult; D001834:Body Water; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016562:Parenteral Nutrition, Home Total / Q000009:adverse effects; D011446:Prospective Studies; D015430:Weight Gain