[Effects of resuscitation with hypertonic sodium lactate dextran 70 on cardiac function in severely burned dogs].
This comparative study was performed to evaluate the effects of resuscitation of burn shock with hypertonic sodium lactate dextran 70(HLD solution: Na+250 mmol/L and 6% dextran 70) and lactate Ringer' solution on cardiac function, lipid peroxide and SOD activity of heart tissue. Dogs with 35% TBSA third degree burns received, one hour postburn, either HLD resuscitation (HLD group, n = 6) in the amount of 19.6 ml.kg-1/g hours, followed by LR 6 ml.kg-1/% TBSA, or LR resuscitation (LR group, n = 6) in the amount of 8 ml.kg-1/% TBSA LR solution. The results of this experiment showed that cardiac index (CI) of HLD group was much higher than that of LR group at 4, 8, 12, 24 hours postburn. The dp/dt max and-dp/dt max of HLD group were much higher than that of LR group at 12.24 hours postburn. Level of MDA in heart tissue of HLD group (1.74 +/- 0.28 10 mol/g heart tissue) was much lower than of LR group (3.23 +/- 0.56 10 mol/g heart tissue) at 24 hours postburn (P < 0.01). Meanwhile, SOD activity in heart tissue of HLD group (157.49 +/- 32.23 u/mg heart tissue) was much higher than that of LR group (46.88 +/- 16.28 u/mg heart tissue) (P < 0.01). These results suggested that HLD resuscitation might be beneficial in improving postburn cardiac function and attenuating postburn oxidant-induced lipid peroxidation in heart tissue not only by its "oxygen scavenger" effect, but also by its elevation of SOD activity of heart tissue.
Zhu
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Burn Institute, Changhai Hospital, Shanghai.
Liu
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Ge
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D000818:Animals; D002056:Burns / Q000150:complications*; D003911:Dextrans / Q000494:pharmacology*; D004285:Dogs; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007552:Isotonic Solutions / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D012151:Resuscitation; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012774:Shock, Traumatic / Q000209:etiology / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000378:metabolism
D003911:Dextrans; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic; D013482:Superoxide Dismutase