Prevention of type I diabetes in the non-obese diabetic (NOD) mouse with 15-deoxyspergualin (15-DS) or 15-DS + cyclosporin A (CyA).
By selectively inbreeding diabetic individuals, we have been able to establish an NOD mouse population with a genetic predisposition towards insulin-dependent diabetes mellitus (IDDM) in approximately 100% of cases. We examined the preventive effect of 15-DS or 15DS + CyA on developing IDDM in these animals. Whereas 15-DS has been proved to be effective in preventing diabetes (significant decrease of the diabetic risk ratio to 0.368 and a reduction of the incidence of the disease to 46.7%), combined treatment with CyA did not produce any additional benefit.
Haberstroh
J
J
Chirurgische Universitätsklinik, Freiburg, Germany.
Wilhelm
T
T
Schulte-Mönting
J
J
Schorlemmer
H U
HU
von Specht
B U
BU
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology* / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D011897:Random Allocation
D006146:Guanidines; D007004:Hypoglycemic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C037258:gusperimus