Bone marrow transplantation from unrelated donors.
Unrelated donor bone marrow transplants provide the alternative to allogeneic transplants for patients lacking an HLA-matched related family member donor. Because the donor and recipient have greater immunogenetic disparity than related donor transplants, these transplants are associated with a higher rate of immunologic complications. This disparity has also translated into a lower risk of relapse relative to sibling donor transplants, enabling this treatment to offer a cure to advanced-disease patients.
Gajewski
J
J
University of Texas M.D. Anderson Cancer Center, Section of Bone Marrow Transplantation, Houston 77030, USA.
Champlin
R
R
D016026:Bone Marrow Transplantation / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors; D016896:Treatment Outcome
D006680:HLA Antigens