title: Subcutaneous botulinum toxin type A inhibits regional sweating: an individual observation.
abstract: Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.
authors.affiliation: Department of Neurology, Mayo Clinic Jacksonville, Florida 32224, USA.
authors.forename: W P
authors.initials: WP
authors.lastname: Cheshire
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D005260:Female; D007007:Hypohidrosis / Q000139:chemically induced*; D007279:Injections, Subcutaneous; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D019274:Botulinum Toxins, Type A