title: Isolation of pyropheophorbide a from the leaves of Atalantia monophylla (ROXB.) CORR. (Rutaceae) as a possible antiviral active principle against herpes simplex virus type 2.
abstract: Antiviral activity-guided isolation studies on the leaves of Atalantia monophylla (ROXB.) CORR. (Rutaceae) led to the identification of pyropheophorbide a (1), a simple chlorin derivative, from the chloroform extract (fr. B) as a possible antiviral active principle against herpes simplex virus type 2 (HSV-2). Pyropheophorbide a methyl ester (2) was also isolated from the hexane extract (fr. A).
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Chansakaow
authors.forename: N
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000254:growth & development; D010936:Plant Extracts / Q000494:pharmacology; D014709:Vero Cells; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts; D002734:Chlorophyll; C040298:pyropheophorbide a