[Effects of allopurinol on damage caused by ischemia and reperfusion of skeletal muscles: an in vivo spectroscopic analysis (31P-MR) in rats].
The effect of allopurinol on energetic metabolism (reutilization of hypoxanthine) has been studied in vivo by mean of 31P-RM spectroscopy on skeletal muscle in the rat in conditions of ischemia and reperfusion. The treatment with allopurinol demonstrates of on benefit or phosphocreatine and ATP kinetics. These results outline that reutilization of hypoxanthine doesn't represent a protective mechanism of allopurinol on skeletal muscles. The role of hypoxanthine reutilization has to be investigated with further researches.
Gürke
L
L
Reparto di chirurgia, Ospedale Civico, Lugano.
Sutter
P M
PM
Kuhrmeier
A
A
Erhard
P
P
Martinoli
S
S
Heberer
M
M
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009132:Muscles / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
D000963:Antimetabolites; D004791:Enzyme Inhibitors; D000493:Allopurinol
Effetto dell'allopurinolo sui danni causati da ischemia e riperfusione nella muscolatura scheletrica: un'analisi spettroscopica (31P-RM) in vivo nel ratto.