[Effect of ligustrazine on kanamycin ototoxicity].
By measuring cochlear superoxide dismutase (SOD) activity, malondialdehyde (MDA) and electrocochleogram (ECoG) in guinea pigs, the antioxidation of Ligustrazine on Kanamycin (KM) was studied. The results showed that SOD activity, MDA content and threshold value of ECoG were significantly increased after KM was administered, while it markedly reduced after Ligustrazine was given. It was considered that lipid hyperoxidative reaction was correlated with KM ototoxicity, Ligustrazine could prevent and treat KM ototoxicity by antioxidation.
She
W D
WD
Affiliated Gulou Hospitalt, Medical College of Nanjing University.
Chen
Z H
ZH
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006168:Guinea Pigs; D034381:Hearing Loss / Q000139:chemically induced / Q000378:metabolism*; D007612:Kanamycin; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D016166:Free Radical Scavengers; D011719:Pyrazines; D008315:Malondialdehyde; D007612:Kanamycin; D013482:Superoxide Dismutase; C017953:tetramethylpyrazine