Use of a tube reservoir system for the pulsed release of nitroglycerin from transdermal plasters.
A novel tube-shaped drug reservoir system has been developed to enable the release of drugs from transdermal plasters to be actively controlled. The system provides a pulsed release of nitroglycerin from a thin PTFE tube, 22 cm long, two sections of which are filled with a solution of nitroglycerin in neutral oil. An electrolysis cell controls the continuous emptying of the tube, which results in the release of 0.5 mg doses of nitroglycerin at an interval of approximately 3 h. The tube reservoir and the electronic control can be incorporated into a normalsized transdermal plaster.
Groning
R
R
Institute for Pharmaceutical Technology, University of Münster, Germany.
Kuhland
U
U
D000279:Administration, Cutaneous; D004304:Dosage Forms; D005996:Nitroglycerin / Q000008:administration & dosage*
D004304:Dosage Forms; D005996:Nitroglycerin