title: Effects of an organophosphate on the antioxidant systems of fish tissues.
abstract: The effect of a Hungarian made and applied insecticide, organophosphate (Dichlorvos) on antioxidant enzymes and other oxidative and redox parameters of two different fish species, carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) was studied. The two fish species have different ways of life. From antioxidant enzymes, changes in superoxide dismutase, catalase, glutathione peroxidase and, in the case of carp, acetylcholinesterase activities were studied in tissue homogenates. Other parameters studied: changes of lipid peroxidation, reduced glutathion and two radicals, which are superoxide and hydroxyl radicals. Our results showed that the organophosphate tested, besides its inhibitory effect on acetylcholinesterase-or together with it-induces changes characteristic of "oxidative stress".
authors.affiliation: Biological Isotope Laboratory of Attila József University, Szeged, Hungary.
authors.forename: D Q
authors.initials: DQ
authors.lastname: Hai
authors.forename: I S
authors.initials: IS
authors.lastname: Varga
authors.forename: B
authors.initials: B
authors.lastname: Matkovics
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002347:Carps / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002397:Catfishes / Q000378:metabolism*; D004006:Dichlorvos / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D007306:Insecticides; D013481:Superoxides; D017665:Hydroxyl Radical; D004006:Dichlorvos; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase; D005978:Glutathione