[Effects of propofol on contractility and electrophysiological properties of canine single cardiomyocytes].
We assessed the effects of propofol on contraction, action potentials and Ca2+ currents (Ica) in single ventricular cells in dog. Low concentrations of propofol 10(-5)M had no effects on contractile responses, but high doses above 10(-4)M of propofol decreased contractions. Propofol 10(-3)M reduced the duration of action potentials (time to 90% repolarization). Ica was decreased by propofol 10(-4)M without accompanying use-dependent manner. The present study indicates that clinical concentrations of propofol do not exert direct negative inotropic effects, but at supratherapeutic concentrations it inhibits cardiac contractility.
Shibuya
N
N
Department of Anesthesiology, Toyama Medical and Pharmaceutical University, Japan.
Higuchi
A
A
Hatakeyama
N
N
Yamazaki
M
M
Ito
Y
Y
Momose
Y
Y
D000200:Action Potentials / Q000187:drug effects; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D015742:Propofol / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D002118:Calcium; D015742:Propofol