The frequency of the haemochromatosis-associated genotype D6S265-1:D6S105-8 in blood donors.
Homozygosity for HLA-A3 and the microsatellite markers D6S265 allele 1 and D6S105 allele 8 is associated with a high relative risk for genetic haemochromatosis-indeed we and others have suggested that a haplotype including D6S265-1, HLA-A3 and D6S105-8 is specific for haemochromatosis. To determine the frequency of this haplotype and examine its specificity for haemochromatosis we have analysed data from 7820 blood donors from South Wales. The frequency of homozygosity for D6S265-1, HLA-A3 and D6S105-8 was 1 in 280. Calculations based on the prevalence of haemochromatosis suggest that about 50% of chromosomes carrying D6S265-1:HLA-A3:D6S105-8 also carry the haemochromatosis gene. This information is of value for assessing the risk that the partner of a patient with haemochromatosis also carries the haemochromatosis gene.
Worwood
M
M
Department of Haematology, University of Wales College of Medicine, Cardiff.
Dorak
M T
MT
Nicklin
S
S
Stone
C
C
Pointon
J
J
Darke
C
C
D000328:Adult; D000368:Aged; D001782:Blood Donors; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015791:HLA-A3 Antigen; D006432:Hemochromatosis / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged
D015791:HLA-A3 Antigen