title: Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia.
abstract: Using a series of yeast artificial chromosomes (YAC) from the Bp11-12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases.
authors.affiliation: Laboratoire d'Hématologie, Höpital Calmettes, Lille, France.
authors.forename: V
authors.initials: V
authors.lastname: Soenen
authors.forename: M
authors.initials: M
authors.lastname: Chaffanet
authors.forename: C
authors.initials: C
authors.lastname: Preudhomme
authors.forename: A
authors.initials: A
authors.lastname: Dib
authors.forename: J L
authors.initials: JL
authors.lastname: Lai
authors.forename: J A
authors.initials: JA
authors.lastname: Fletcher
authors.forename: D
authors.initials: D
authors.lastname: Birnbaurn
authors.forename: M J
authors.initials: MJ
authors.lastname: Pébusque
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic