title: Gabapentin adjunctive therapy in neuropathic pain states.
abstract: OBJECTIVE
  This is a report of a trial of the new antiepileptic agent gabapentin in patients with intractable neuropathic pain.
  
  
  METHODS
  A case series of patients with a diagnosis of neuropathic pain whose previous management was inadequate were given oral gabapentin in increasing doses and were followed for a minimum of 2 months, monitored for efficacy and side effects.
  
  
  METHODS
  An outpatient pain management center located within a major university medical center.
  
  
  METHODS
  Convenience sample of patients referred for management of intractable neuropathic pain.
  
  
  METHODS
  Simplification of existing pharmacologic management, addition of gabapentin, and attempted reduction of opiate analgesic doses.
  
  
  METHODS
  Patient self-reports and pain scores in successive office visits.
  
  
  RESULTS
  Gabapentin provides analgesic activity for patients with neuropathic pain and has the advantage of a low side effect profile and drug toxicity.
authors.affiliation: Department of Anesthesiology, New York Hospital, Cornell Medical Center, New York 10021, USA.
authors.forename: H
authors.initials: H
authors.lastname: Rosner
authors.forename: L
authors.initials: L
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Kestenbaum
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000588:Amines; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D005157:Facial Pain / Q000188:drug therapy; D005260:Female; D000077206:Gabapentin; D015658:HIV Infections / Q000150:complications; D006566:Herpesviridae Infections / Q000150:complications; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy / Q000209:etiology; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin