title: Ketorolac appears to decrease polyuria during intracranial surgery.
abstract: Two cases are described of patients, undergoing surgery for intracranial pathology, who developed polyuria intraoperatively. The urine output decreased to within normal range shortly after the administration of ketorolac, a nonsteroidal antiinflammatory drug. The possible mechanisms producing the increased urinary output and the influence of prostaglandins on renal function are discussed.
authors.affiliation: Department of Anesthesiology, St. Louis University Health Sciences Center, MO 63110, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Williams
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003399:Craniotomy; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D007476:Ionophores; D020910:Ketorolac; D008297:Male; D008875:Middle Aged; D011141:Polyuria / Q000188:drug therapy* / Q000209:etiology; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007476:Ionophores; D014046:Tolmetin; D020910:Ketorolac