Fluoxetin-induced pulmonary granulomatosis.
A patient treated with fluoxetin for a manic depressive disorder developed pulmonary inflammatory nodules with noncaseating giant cell granulomas, interstitial pneumonia and non-necrotizing vasculitis, whilst remaining asymptomatic. A progressive resolution of pulmonary nodules occurred after withdrawal of the offending agent, and the chest radiograph returned to normal in 9 months. The diagnosis was assessed by an open lung biopsy.
de Kerviler
E
E
Service de Radiologie, Hôpital Saint-Louis, Paris, France.
Trédaniel
J
J
Revlon
G
G
Groussard
O
O
Zalcman
G
G
Ortoli
J M
JM
Espié
M
M
Hirsch
A
A
Frija
J
J
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006101:Granuloma, Giant Cell / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine