title: [Primary myelofibrosis with severe bone pain].
abstract: An 80-year-old man was admitted with bone pain, affecting both lower limbs and the dorsa of the feet, in September, 1991. Primary myelofibrosis was diagnosed. Bilateral x-ray films of the tibia, fibula, femur and vertebra revealed osteoporosis, but this was considered an unlikely source of the bone pain. The bone pain subsequently disappeared, but then became severe in both lower limbs and the dorsa of the feet and was accompanied by leukemic transformations in February, 1992. He died of aspiration pneumonia in July, 1992. Autopsy revealed microfractures with osteoporosis and infiltration of leukemic cells in the periosteum of the left tibia, which may have caused the bone pain. This case provides useful information to analyze the cause of bone pain in patients with myelofibrosis.
authors.affiliation: Department of Hematology Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kikukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Arie
authors.forename: K
authors.initials: K
authors.lastname: Kuramoto
authors.forename: H
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: M
authors.initials: M
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Kumakawa
authors.forename: M
authors.initials: M
authors.lastname: Sawabe
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000473:pathology; D001842:Bone and Bones; D005598:Fractures, Spontaneous / Q000150:complications / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D010148:Intractable Pain / Q000209:etiology*; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology