Autologous red cell recovery and relapse of multiple myeloma after bone marrow transplantation: is this a graft-versus-myeloma effect?
We report a patient who, following an allogeneic bone marrow transplant for multiple myeloma, recovered autologous erythropoiesis which was rapidly followed by relapse of her multiple myeloma. We postulate that the loss of the graft (as demonstrated by loss of donor erythropoiesis) and subsequent relapse of the multiple myeloma may be support for the existence of a graft-versus-myeloma effect.
Forsyth
C
C
Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia.
Nelson
M
M
Popp
H
H
Snowdon
L
L
Gibson
J
J
Joshua
D
D
D000328:Adult; D001804:Blood Transfusion, Autologous; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017707:Erythrocyte Transfusion; D004920:Erythropoiesis / Q000502:physiology*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D009101:Multiple Myeloma / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D014184:Transplantation, Homologous