title: [Adenosine deaminase in the cerebrospinal fluid of patients with acquired immunodeficiency syndrome].
abstract: The adenosine-deaminase (ADA) activity was evaluated in CSF samples from 263 patients with AIDS. An elevated ADA activity in CSF was found in patients with: antibodies to toxoplasmosis, syphilis or cytomegalovirus; Cryptococcus neoformans or their antigens; tuberculous meningitis; lymphoma. There was no statistical difference among all these groups in respect to ADA activity. However, the ADA activity in CSF from AIDS patients without CSF changes other than HIV antibodies, even unspecific changes, was not elevated. This may suggest that ADA is related to AIDS associated pathologies activity rather than to HIV infection itself.
authors.affiliation: Departamento de Neurologia, Universidade de São Paulo, Brasil.
authors.forename: L D
authors.initials: LD
authors.lastname: Machado
authors.forename: J A
authors.initials: JA
authors.lastname: Livramento
authors.forename: A
authors.initials: A
authors.lastname: Spina-França
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000201:enzymology*; D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications / Q000201:enzymology; D000243:Adenosine Deaminase / Q000134:cerebrospinal fluid*; D015483:HIV Antibodies / Q000134:cerebrospinal fluid; D006801:Humans
chemical_list: D015483:HIV Antibodies; D000243:Adenosine Deaminase
vernacular_title: Adenosino-deaminase no líquido celalorraqueano de pacientes com a síndrome da imunodeficiência adquirida.