EPR-spin trapping kinetic studies of superoxide radicals produced by photosensitized hypocrellin A. A photodynamic therapeutic agent.
Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10(-3) s-1. The first-order rate constant (k1) and the half-life time (t0.5) for DMPO-O2- decay were 2.86 x 10(-3) s-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.
Zang
L Y
LY
Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061-0442, USA.
Shi
X
X
Misra
H P
HP
D004578:Electron Spin Resonance Spectroscopy; D006207:Half-Life; D007700:Kinetics; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D019800:Phenol; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry*; D019097:Spin Trapping; D013481:Superoxides / Q000737:chemistry*
D017319:Photosensitizing Agents; D011809:Quinones; D013481:Superoxides; D019800:Phenol; D010569:Perylene; C048388:hypocrellin A