Role of verotoxin receptors in pathogenesis.
Verotoxin-globotriaosyl ceramide (Gb3) binding is the linchpin in disease induced by verotoxin-producing Escherichia coli (VTEC), and defines cell sensitivity, tissue tropism, mode of systemic transport, specific cytotoxic activity and internal routing within sensitive cells. Binding explains the epidemiology of renal pathology, which may follow VTEC infection. Lipid heterogeneity of Gb3 is important in binding, and may define a growth-related signal transduction pathway used by verotoxin.
Lingwood
C A
CA
Hospital for Sick Children, Dept of Microbiology, Toronto, Ontario, Canada.
D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism*; D002240:Carbohydrate Sequence; D004768:Enterotoxins / Q000378:metabolism*; D004926:Escherichia coli / Q000472:pathogenicity*; D005732:Gangliosides / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000378:metabolism*; D022622:Shiga Toxin 1
D001427:Bacterial Toxins; D004768:Enterotoxins; D005732:Gangliosides; D011956:Receptors, Cell Surface; D022622:Shiga Toxin 1; C033639:glycolipid receptor; C054370:galabiosylceramide