[Metabolic tolerance of isradipine. Evaluation after three months of therapy].
The aim of the present study was to evaluate efficacy on blood pressure values and metabolic tolerability of Isradipine, which was given to 15 mild hypertensive non diabetic subjects (average age 63.8 +/- 10.9 years), at the dosage of 5 mg once a day. Plasma lipids concentrations and oral glucose tolerance test (OGGT) with plasma insulin assay were carrid out before, after one and three months of therapy. The statistical analysis was done using the Student's t test for paired data. Isradipine showed a good efficacy on lowering high blood pressure. In no patients the drug induced impaired glucose tolerance. Isradipine had contrasting, but not statistically significant effects on lipid concentrations, namely, decrease of triglycerides, increased of any form of cholesterol (total, HDL, LDL), apoproteins and lipoprotein(a).
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Divisione di Medicina Interna, Ospedale Simiani di Loiano, BO.
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MR
Bernardini
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Capone
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D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D003324:Coronary Artery Disease / Q000517:prevention & control*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017275:Isradipine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008660:Metabolism / Q000187:drug effects; D008875:Middle Aged
D002121:Calcium Channel Blockers; D017275:Isradipine
Tollerabilità metabolica dell'isradipina. Valutazione dopo tre mesi di terapia.