Effects of in vivo cocaine administration on human platelet aggregation.
To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.
Heesch
C M
CM
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Negus
B H
BH
Steiner
M
M
Snyder RW
I I
II
McIntire
D D
DD
Grayburn
P A
PA
Ashcraft
J
J
Hernández
J A
JA
Eichhorn
E J
EJ
D000328:Adult; D000704:Analysis of Variance; D003042:Cocaine / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009391:Nephelometry and Turbidimetry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011446:Prospective Studies
D010975:Platelet Aggregation Inhibitors; D003042:Cocaine