[Study on antifertility mechanisms of tripchlorolide (T4)].
Hyaluronidase activities of testes and epididymides in rats were obviously inhibited by T4 po at dosage of 0.1 mg.kg-1/d for 7 weeks. T4 at dosage of 0.1 mg.kg-1/d for 3 weeks decreased GSH content in epididymides in rats. However, in vitro T4 at concentration of 10 micrograms/ml was found to exert no effect on the content of malondialdehyde in testis or H2O2 in testis and epididymis microsomes in rats.
Zuo
X
X
Institute of Materia Medica, CAMS and PUMC, Beijing.
Wang
N
N
D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D004822:Epididymis / Q000201:enzymology; D005978:Glutathione / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000378:metabolism*; D008297:Male; D010616:Phenanthrenes; D051381:Rats; D017208:Rats, Wistar; D013089:Spermatocidal Agents / Q000494:pharmacology*; D013737:Testis / Q000201:enzymology*
D004224:Diterpenes; D010616:Phenanthrenes; D013089:Spermatocidal Agents; C068051:tripchlorolide; D006821:Hyaluronoglucosaminidase; D005978:Glutathione