title: EEG-triggered echo-planar functional MRI in epilepsy.
abstract: We investigated whether: (1) EEG recordings could be successfully performed in an MRI imager, (2) subclinical epileptic discharges could be used to trigger ultrafast functional MRI images, (3) artifact-free functional MRI images could be obtained while the patient was having the EEG monitored, and (4) the functional MRI images so obtained would show focal signal increases in relation to epileptic discharges. We report our results in two patients who showed focally higher signal intensity, reflective of increased local blood flow, in ultrafast functional MRI timed to epileptic discharges recorded while the patients were in the imager and compared with images not associated with discharges. One patient showed a focal increase despite a clinical and EEG history of generalized discharges. This approach may have the potential to identify brain regions activated during brief focal epileptic discharges.
authors.affiliation: Department of Neurnlogy, Beth Israel Hospital, Boston, MA 02215, USA.
authors.forename: S
authors.initials: S
authors.lastname: Warach
authors.forename: J R
authors.initials: JR
authors.lastname: Ives
authors.forename: G
authors.initials: G
authors.lastname: Schlaug
authors.forename: M R
authors.initials: MR
authors.lastname: Patel
authors.forename: D G
authors.initials: DG
authors.lastname: Darby
authors.forename: V
authors.initials: V
authors.lastname: Thangaraj
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
authors.forename: D L
authors.initials: DL
authors.lastname: Schomer
mesh_terms: D000328:Adult; D017352:Echo-Planar Imaging; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging