title: Didanosine measurement by radioimmunoassay.
abstract: Didanosine is commonly prescribed as monotherapy or as part of a combination regimen for patients with human immunodeficiency virus infection. The use of lower doses, either as part of a combination regimen or as a result of dose reduction secondary to clinical intolerance, requires that a sensitive assay method be available for either traditional or population-based pharmacokinetic evaluations. We evaluated a radioimmunoassay technique with a standard curve range of 0 to 100 ng/ml in human plasma, urine, and cerebrospinal fluid and assessed its accuracy and precision for use in pharmacokinetic studies.
authors.affiliation: Department of Pharmacy Practice, State University of New York at Buffalo, USA.
authors.forename: M
authors.initials: M
authors.lastname: DeRemer
authors.forename: R
authors.initials: R
authors.lastname: D'Ambrosio
authors.forename: G D
authors.initials: GD
authors.lastname: Morse
mesh_terms: D000998:Antiviral Agents / Q000032:analysis* / Q000493:pharmacokinetics; D016049:Didanosine / Q000032:analysis* / Q000493:pharmacokinetics; D006801:Humans; D011863:Radioimmunoassay / Q000379:methods*
chemical_list: D000998:Antiviral Agents; D016049:Didanosine