[The pharmacological properties of a direct-action anticoagulant from the herb Nonea poulla (L.) D. C].
Nondialyzed fraction of the ammonia extract from Siberian grass Nonea poulla is studied. A stable hypocoagulemy (without cumulative activity) was found in the experiments in vitro and in vivo carried out on rats (intravenous administration of the extract). The LD50 was 150 mg/kg at the effective dose of 10 mg/kg. Intraperitoneal and intramuscular administration during 20 days exerted neither hypocoagulemic nor toxic effect on the haemopoesis system and did not change the body weight of the animals.
Gubaev
A G
AG
Ortenberg
E A
EA
Rusakova
O A
OA
Chiriat'ev
E A
EA
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology* / Q000633:toxicity; D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats; D012800:Siberia; D013997:Time Factors
D000925:Anticoagulants; D010936:Plant Extracts
Farmakologicheskie svoĭsta antikoagulianta priamogo deĭstviia iz travy Noneia temnaia (Nonea poulla (L.) D. C.).