title: [Features of inhibiting butyrylcholinesterase and carboxylesterase hydrolysis with fluoranhydride esters of beta,beta-diphenylethylphosphonic acid].
abstract: A new type of organophosphorus compounds-beta, beta-diphenylethylphosphonic acid fluoroanhydride esters-with various alkyl radicals (CH3, C2H5, C3H7, i-C3H7, C4H9, i-C4H9, C5H11, C6H13) and a phenyl radical (C6H5) have been tested as inhibitors of horse serum butyryl cholinesterase (EC 3.1.1.8) and two forms of reindeer liver carboxyl esterase (EC 3.1.1.1). All the tested compounds are strong irreversible inhibitors of butyryl cholinesterase and strong combined type inhibitors of carboxylesterase. The values of inhibitory constants have been found to depend on the structure of the alkyl radical in the inhibitor molecule.
authors.forename: A P
authors.initials: AP
authors.lastname: Brestkin
authors.forename: E A
authors.initials: EA
authors.lastname: Efimtseva
authors.forename: L P
authors.initials: LP
authors.lastname: Kuznetsova
authors.forename: E B
authors.initials: EB
authors.lastname: Nikol'skaia
authors.forename: S V
authors.initials: SV
authors.lastname: Fridland
mesh_terms: D000812:Anhydrides / Q000737:chemistry; D000818:Animals; D002091:Butyrylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005459:Fluorides / Q000737:chemistry; D006736:Horses; D006868:Hydrolysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D012053:Reindeer
chemical_list: D000812:Anhydrides; D002800:Cholinesterase Inhibitors; D063065:Organophosphonates; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D002091:Butyrylcholinesterase; D005459:Fluorides
vernacular_title: Osobennosti ingibirovaniia butirilkholinésteraznogo i karboksilésteraznogo gidroliza éfirami ftorangidrida beta,beta-difenilétilfosfonovoĭ kisloty.