DNA double-strand break repair functions defend against parvovirus infection.
We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.
Tauer
T J
TJ
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495, USA.
Schneiderman
M H
MH
Vishwanatha
J K
JK
Rhode
S L
SL
D000818:Animals; D016466:CHO Cells; D002467:Cell Nucleus / Q000821:virology; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D017992:Parvovirus / Q000472:pathogenicity / Q000502:physiology* / Q000528:radiation effects; D011991:Receptors, Virus / Q000502:physiology / Q000528:radiation effects*; D014779:Virus Replication / Q000528:radiation effects*
D011991:Receptors, Virus