title: Crystals of the neurotrophins.
abstract: The neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X-ray characterization of three neurotrophins: brain-derived neurotrophin, neurotrophin 3, and the heterodimer between brain-derived neurotrophin and neurotrophin 4. These findings are related to other published crystal parameters for neurotrophins, leading to the observation that, although crystal packing is highly variant, neurotrophins share common solubilities with respect to crystal growth.
authors.affiliation: Laboratory of Molecular Biophysics & Oxford Centre for Molecular Sciences.
authors.forename: R C
authors.initials: RC
authors.lastname: Robinson
authors.forename: C
authors.initials: C
authors.lastname: Radziejewski
authors.forename: D I
authors.initials: DI
authors.lastname: Stuart
authors.forename: E Y
authors.initials: EY
authors.lastname: Jones
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans; D009414:Nerve Growth Factors / Q000737:chemistry*; D020933:Neurotrophin 3; D055503:Protein Multimerization; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D011994:Recombinant Proteins; C073922:neurotrophin 4