Morphine-augmented hepatobiliary scintigraphy: a meta-analysis.
The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HBS often include non-candidates for MA-HBS. However, using meta-analytic techniques to combine data from eligible studies (4 for C-HBS and 5 for MA-HBS), the specificity of MA-HBS (0.84; 95% CI = 0.75-0.94) was significantly greater (P = 0.008) than that of C-HBS (0.68; 95% CI = 0.61-0.75); there were no differences in sensitivity (MA-HBS; 0.96, 95% CI = 0.92-0.99; C-HBS: 0.97, 95% CI = 0.97-0.99).
Cabana
M D
MD
Johns Hopkins University Hospital, Baltimore, MD, USA.
Alavi
A
A
Berlin
J A
JA
Shea
J A
JA
Kim
C K
CK
Williams
S V
SV
D000208:Acute Disease; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D002764:Cholecystitis / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D015201:Meta-Analysis as Topic; D009020:Morphine; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
D009020:Morphine