title: Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica.
abstract: Two novel cyclic peptides were isolated from the latex of Jatropha podagrica, which we named podacycline A and B. Podacycline A is a cyclic nonapeptide with the sequence Gly1-Leu2-Leu3-Gly4-Ala5-Val6-Trp7-Ala8-Gly9+ ++-Gly1. The sequence of podacycline B, a cyclic heptapeptide, was determined to be Phe1-Ala2-Gly3-Thr4-Ile5-Phe6-Gly7-Phe1. The amino acid residues of both compounds were found to have the L-configuration.
authors.affiliation: Department of Pharmacognosy, Universiteit Utrecht, Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Van den Berg
authors.forename: S F
authors.initials: SF
authors.lastname: Horsten
authors.forename: J J
authors.initials: JJ
authors.lastname: Kettenes-van den Bosch
authors.forename: C J
authors.initials: CJ
authors.lastname: Beukelman
authors.forename: B H
authors.initials: BH
authors.lastname: Kroes
authors.forename: B R
authors.initials: BR
authors.lastname: Leeflang
authors.forename: R P
authors.initials: RP
authors.lastname: Labadie
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D002852:Chromatography, Ion Exchange; D007840:Latex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000596:Amino Acids; D007840:Latex; D010456:Peptides, Cyclic; C101842:podacycline A; C101843:podacycline B