The ecology and pathology of Epstein-Barr virus.
Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication in epithelial cells. Both of these cell compartments are potential sites for EBV-associated malignancies.
Schmidt
C W
CW
Queensland Institute of Medical Research, The Bancroft Centre, Brisbane, Australia.
Misko
I S
IS
D002051:Burkitt Lymphoma / Q000821:virology; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D006689:Hodgkin Disease / Q000821:virology; D007244:Infectious Mononucleosis / Q000821:virology; D009303:Nasopharyngeal Neoplasms / Q000821:virology; D017735:Virus Latency; D014779:Virus Replication