title: [Non-invasive diagnosis of rejection in heart transplant: usefulness of Doppler echocardiography].
abstract: Cardiac transplantation is a valid therapeutic option for advanced chronic heart failure, with a one year survival of 60-80%. Although the introduction of cyclosporine has markedly improved survival in heart transplant recipients, early detection of cardiac allograft rejection remains the major problem to be solved. At present, the diagnosis of cardiac rejection has been based on the results of endomyocardial biopsy, which remains actually as the gold standard for rejection surveillance. However, ideally the detection of cardiac rejection should be noninvasive to allow frequent follow-up of the patients. Several attempts have been made to find a noninvasive alternative to replace endomyocardial biopsy, doppler-echocardiography being the most promising technique. A review of current noninvasive methods for graft rejection detection will be discussed emphasising the importance of doppler-echocardiography.
authors.affiliation: Departamento de Cardiología y Cirugía Cardiovascular, Universidad de Navarra, Pamplona.
authors.forename: J
authors.initials: J
authors.lastname: Barba
authors.forename: A C
authors.initials: AC
authors.lastname: Abecia
authors.forename: J A
authors.initials: JA
authors.lastname: Gómez
authors.forename: A
authors.initials: A
authors.lastname: Pellicelli
authors.forename: I
authors.initials: I
authors.lastname: Iglesias
authors.forename: C
authors.initials: C
authors.lastname: Díaz
authors.forename: D
authors.initials: D
authors.lastname: Lozano
authors.forename: J
authors.initials: J
authors.lastname: Herreros
authors.forename: R
authors.initials: R
authors.lastname: Llorens
authors.forename: D
authors.initials: D
authors.lastname: Martínez Caro
mesh_terms: D015150:Echocardiography, Doppler; D006084:Graft Rejection / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016027:Heart Transplantation / Q000000981:diagnostic imaging* / Q000502:physiology; D006801:Humans
vernacular_title: Diagnóstico no invasivo del rechazo en el trasplante cardiaco: utilidad de la ecocardiografía-Doppler.