title: International safety assessment of pesticides: dithiocarbamate pesticides, ETU, and PTU--a review and update.
abstract: For the last 30 years the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) has carried out toxicological evaluations and safety assessments of dithiocarbamate pesticides, continuously adjusting previous appraisals in the light of new data and advances in the understanding of the principles and mechanisms of toxic action of these compounds. The historical narrative of the evaluative process is followed by an account of the present international safety assessment status of the dithiocarbamate pesticides so far examined by the JMPR. They are ferbam, mancozeb, maneb, metiram, nabam, propineb, thiram, zineb, ziram, and the associated substances, ethylenethiourea (ETU) and propylenethiourea (PTU).
authors.affiliation: International Toxicology Information Centre, San Sebastian, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Vettorazzi
authors.forename: W F
authors.initials: WF
authors.lastname: Almeida
authors.forename: G J
authors.initials: GJ
authors.lastname: Burin
authors.forename: R B
authors.initials: RB
authors.lastname: Jaeger
authors.forename: F R
authors.initials: FR
authors.lastname: Puga
authors.forename: A F
authors.initials: AF
authors.lastname: Rahde
authors.forename: F G
authors.initials: FG
authors.lastname: Reyes
authors.forename: S
authors.initials: S
authors.lastname: Schvartsman
mesh_terms: D000818:Animals; D002219:Carbamates; D002273:Carcinogens / Q000633:toxicity*; D005031:Ethylenethiourea / Q000633:toxicity*; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010573:Pesticide Residues / Q000633:toxicity*; D012449:Safety; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000633:toxicity; D014944:World Health Organization
chemical_list: D002219:Carbamates; D002273:Carcinogens; D007306:Insecticides; D010573:Pesticide Residues; C035039:propylenethiourea; D005031:Ethylenethiourea; D013890:Thiourea