title: Proinsulin secretion during the first 3 years after diagnosis in diabetic patients with and without islet cell antibodies.
abstract: OBJECTIVE
  To evaluate proinsulin secretion in different types of NIDDM.
  
  
  METHODS
  Proinsulin and insulin were evaluated at diagnosis of diabetes and 3 years later (fasting and after stimulation with intravenous glucose and glucagon) in 10 NIDDM patients without islet cell antibodies (ICAs) at diagnosis (age 52 +/- 4 years), 11 NIDDM patients with ICAs at diagnosis (age 50 +/- 5 years), and 21 healthy control subjects (age 53 +/- 4 years).
  
  
  RESULTS
  At diagnosis, fasting proinsulin was higher in NIDDM patients without ICAs than in control subjects (39.6 +/- 10.0 vs. 12.8 +/- 1.6 pmol/l, P < 0.01). Proinsulin response to intravenous glucose decreased in NIDDM patients with ICAs (from 35.6 +/- 6.2 to 13.5 +/- 5.4 pmol/l, P < 0.05), but remained unchanged in those without ICAs. At 3 years after diagnosis, fasting proinsulin (10.0 +/- 3.7 vs. 59.1 +/- 17.0 pmol/l) and proinsulin responses to intravenous glucose (13.5 +/- 5.4 vs. 103.9 +/- 35.1 pmol/l) and to intravenous glucagon (7.4 +/- 3.9 vs. 36.0 +/- 7.7 pmol/l) were much lower (P < 0.01) in NIDDM patients with ICAs than in those without ICAs.
  
  
  CONCLUSIONS
  After diagnosis of diabetes, proinsulin secretion decreases significantly in NIDDM patients with ICAs and remains constant in those without.
authors.affiliation: Department of Vascular and Renal Diseases, University of Lund, University Hospital MAS, Malmö, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Gottsäter
authors.forename: D R
authors.initials: DR
authors.lastname: Owens
authors.forename: S
authors.initials: S
authors.lastname: Luzio
authors.forename: G
authors.initials: G
authors.lastname: Sundkvist
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D005215:Fasting; D005500:Follow-Up Studies; D005934:Glucagon; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood / Q000378:metabolism*; D012016:Reference Values; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D007328:Insulin; C024211:islet cell antibody; D005934:Glucagon; D011384:Proinsulin