3-Diazopyrroles. Part 6. Mutagenic activity of 3-diazopyrroles in Streptomyces coelicolor A3(2) during various phases of growth.
3-Diazopyrroles, a class of compounds particularly interesting from a chemical and biological point of view, were assayed for their ability to induce gene mutations employing back mutation (his+ reversion) test in the philamentous bacterium Streptomyces coelicolor at various time during life cycle. Our results suggest that in evaluating the mutagenicity and toxicity of chemicals in Streptomyces system it is important to consider factors such as growth phase. Furthermore in this series of diazopyrroles a relationship between toxicity, mutagenicity and chemical structure was found. The observed mutagenic activity can be the molecular basis for the appearance of antitumor activity.
Cirrincione
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Istituto Farmacochimico, Università di Palermo, Italy.
Almerico
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AM
Grimaudo
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S
Diana
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P
Mingoia
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Barraja
P
P
Misuraca
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D001391:Azo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D013329:Structure-Activity Relationship
D001391:Azo Compounds; D009153:Mutagens; D011758:Pyrroles