[The modifying action of a complex of physiologically active substances isolated from the human amnion on chromosome damage].
It was determined that the complex of physiological active substances separated from human amnion reduced the frequency of the hepatocytes with chromosomal aberrations in rats. This reduction of chromosomal damages was noted at spontaneous and induced mutagenesis. The value of cytogenetical effect, the availability of raw material and the natural origin of the drug allow to propose it for further study and use as modifier of mutagenic action.
Timchenko
O I
OI
Borshchevskaia
M I
MI
Ianchevskaia
N V
NV
D000650:Amnion / Q000502:physiology*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002869:Chromosome Aberrations; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D008872:Microwaves; D016296:Mutagenesis / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D016587:Antimutagenic Agents; D014020:Tissue Extracts; D013974:Thyroxine
Modifitsruiushchee vliianie kompleksa fiziologicheski aktivnykh veshchestv, vydelennykh iz amniona cheloveka, na povrezhdenie khromosom.