title: [The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity].
abstract: The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine. Intracutaneous administration of both peptides (300 micrograms/kg) was found to result in weakening perception of stress situations; an increase in stability of investigation behavior and normalization of serotonin level in the brain of rats with chronic deprivation of serotoninergic system activity. Anxiolytic and psychostimulant activities of TP-7 are more pronounced than those of tafcine.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: T P
authors.initials: TP
authors.lastname: Semenova
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaia
authors.forename: N I
authors.initials: NI
authors.lastname: Medvinskaia
authors.forename: V N
authors.initials: VN
authors.lastname: Nezovibat'ko
mesh_terms: D015116:5,7-Dihydroxytryptamine; D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents; D013997:Time Factors; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D014405:Tuftsin; C100827:TP 7
vernacular_title: Osobennosti anksioliticheskogo deĭstviia taftsina i ego analoga TP-7 na povedenie i obmen serotonina v mozge krys s khronicheskoĭ deprivatsieĭ aktivnosti serotoninergicheskoĭ sistemy.