5-Hydroxytryptamine in the central nervous system.
The review summarizes the results of studies into the role of 5-HT as a neurotransmitter in the central nervous system. The biosynthesis, release, metabolism and distribution of 5-HT; classification and localization of 5-HT receptors; electrophysiological effects of 5-HT and its influence on second messengers; autoregulation of 5-HT release; effects of 5-HT on the release of other neurotransmitters and pituary hormones; behavioral effects induced by 5-HT receptor agonists and the functional interaction between different receptor subtypes have been described. Additionally, some data on functional changes in the 5-HT system in psychiatric disorders have been cited, and a possibility of clinical utilization of 5-HT-active related drugs in neuropsychiatric and other diseases has been reviewed.
Chojnacka-Wójcik
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Department of New Drug Research, Polish Academy of Sciences, Kraków, Poland.
D000544:Alzheimer Disease; D001923:Brain Chemistry; D003863:Depression; D006801:Humans; D011985:Receptors, Serotonin / Q000032:analysis / Q000145:classification / Q000502:physiology*; D012559:Schizophrenia; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*
D011985:Receptors, Serotonin; D012701:Serotonin