Emollients and photo(chemo)therapy: a call for caution.
BACKGROUND
Emollients used for skin care, treatment of a disease or lubrication, before irradiation during the course of phototherapy or photochemotherapy, may significantly interfere with the transmission of UV light and may influence the outcome of the therapy.


OBJECTIVE
These experiments should characterize and quantify the possible interactions of usual emollients with UV light transmission.


METHODS
The method was an in vitro technique similar to the one already used for the determination of sun protection factors of topical sunscreen preparations.


RESULTS
Among the products tested, two showed a significant photoprotection capable of interfering with the course of therapy. Oils enhanced UV light transmission significantly.


CONCLUSIONS
Emollients may show significant interference with UV light transmission during phototherapy or photochemotherapy. The outcome and course of the therapy could thus be significantly modified.
Gabard
B
B
Department of Biopharmacy, Spirig Ltd., Egerkingen, Switzerland.
Treffel
P
P
Bieli
E
E
Schwab
S
S
D000075202:Contraindications; D004643:Emollients / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D008962:Models, Theoretical; D010778:Photochemotherapy; D010789:Phototherapy; D014466:Ultraviolet Rays
D004643:Emollients