[A randomized controlled clinical trial of sulperazone as compared with cefotaxime in the treatment of bacterial infections].
A randomized controlled clinical trial of sulperazone as compared with cefotaxime was conducted. 207 patients with bacterial infections entered the study. The overall clinical efficacy rate of sulperazone and cefotaxime was 95.15% and 90.38% respectively. The bacterial clearance rate in the two groups was 84.7% and 80.6% respectively. The adverse drug reactions in both groups were mild with the rate of 7.77% and 8.65% respectively; there was no statistical difference between the two groups. The results of disc susceptibility test showed that the sensitive rate of the clinical isolates to sulperazone was 90.9%, being significantly higher than that of cefotaxime 69.3% (P < 0.001).
Li
J
J
Institute of Clinical Pharmacology, Beijing Medical University.
Miao
J
J
Hu
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002438:Cefoperazone / Q000627:therapeutic use*; D002439:Cefotaxime / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013407:Sulbactam / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D002438:Cefoperazone; C057923:sulperazone; D002439:Cefotaxime; D013407:Sulbactam