title: Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia.
abstract: Serotonin-5-HT1A receptors were measured with [3H]8-hydroxy-2-(di-n-propyl)aminotetralin ([3H]8-OH-DPAT) in postmortem prefrontal cortex of 12 pairs of subjects with schizophrenia and age-matched control subjects. The saturation binding isotherms of [3H]8-OH-DPAT revealed high- and low-affinity binding sites. The density (Bmax) of the high-affinity sites was significantly elevated by an average of 79% in subjects with schizophrenia. The dissociation constant (Kd) of the high-affinity sites in subjects with schizophrenia was not significantly different from the control subjects. These results provide further evidence for a role of the serotonergic system in the pathophysiology of schizophrenia.
authors.affiliation: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106-500, USA.
authors.forename: T
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: C A
authors.initials: CA
authors.lastname: Stockmeier
authors.forename: J C
authors.initials: JC
authors.lastname: Overholser
authors.forename: G E
authors.initials: GE
authors.lastname: Dilley
authors.forename: H Y
authors.initials: HY
authors.lastname: Meltzer
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism*; D000328:Adult; D001344:Autopsy; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000032:analysis / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D012016:Reference Values; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology; D014316:Tritium
chemical_list: D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D014316:Tritium; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin