title: Metacarpal growth and systemic markers of bone metabolism in the ovine fetus.
abstract: Bone metabolism was assessed in 56 Ile de Francex(RomanovxLimousine) fetal lambs killed between Day 80 and Day 145 of gestation. In each fetus, the length, width and weight, as well as the calcium and phosphorus content of the left diaphyseal metacarpal bone were measured. Plasma alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities, bone ALP (B-ALP), osteocalcin (OC) and insulin-like growth factor-I (IGF-I) were assayed in these fetuses and in six newborn lambs from birth until one month after birth. Fetal growth is characterized by an increase in bodyweight, bone size and bone mineral content from Day 80 to Day 132 of gestation. These parameters did not significantly vary until birth. Plasma concentrations of IGF-1, OC and B-ALP increased from Day 80 to Day 132. Between Day 132 and birth, plasma IGF-I and B-ALP concentrations did not significantly vary, whereas plasma OC concentration decreased, confirming the usefulness of OC as a marker of osteoblastic activity and bone formation in the ovine species. The increase in plasma IGF-I, B-ALP and OC concentrations observed during the first two weeks of postnatal life indicate an intense skeletal growth in these animals, which was confirmed by the bodyweight growth curve.
authors.affiliation: Laboratoire Croissance et Métabolisme des Herbivores, INRA Clermont-Theix, Ceyrat, France.
authors.forename: H
authors.initials: H
authors.lastname: Collignon
authors.forename: M J
authors.initials: MJ
authors.lastname: Davicco
authors.forename: J P
authors.initials: JP
authors.lastname: Barlet
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn / Q000097:blood; D015415:Biomarkers; D001842:Bone and Bones / Q000196:embryology* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005865:Gestational Age; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008663:Metacarpus / Q000196:embryology; D015675:Osteocalcin / Q000097:blood; D010758:Phosphorus / Q000378:metabolism; D012756:Sheep / Q000196:embryology*
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D010758:Phosphorus; D007334:Insulin-Like Growth Factor I; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002118:Calcium