Leishmania (viannia) panamensis-induced cutaneous leishmaniasis in susceptible and resistant mouse strains.
We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed.
Goto
H
H
Department of Pathology, Universidade de São Paulo, Brazil.
Rojas
J I
JI
Sporrong
L
L
De Carreira
P
P
Sánchez
C
C
Orn
A
A
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis / Q000276:immunology*; D000953:Antigens, Protozoan / Q000096:biosynthesis*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005260:Female; D007111:Immunity, Cellular; D007114:Immunization; D018334:Leishmania guyanensis / Q000276:immunology* / Q000472:pathogenicity; D007897:Leishmaniasis, Mucocutaneous / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan