A benzoic acid glycoside from Geniostoma antherotrichum.
Fractionation of an HIV-inhibitory organic extract of Geniostoma antherotrichum afforded a glycoside derivative, which has been characterized as 2-hydroxy-3-O-beta-D-glucopyranosyl-benzoic acid (1) on the basis of spectral analyses. The HIV-inhibitory activity of the extract was traced to polymeric tannins, while 1 was found to be inactive in the National Cancer Institute's primary anti-HIV screen.
Rashid
M A
MA
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, MD 21702-1201, USA.
Gustafson
K R
KR
Cardellina
J H
JH
Boyd
M R
MR
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006678:HIV / Q000187:drug effects; D010944:Plants / Q000737:chemistry*; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis
C101330:2-hydroxy-3-O-glucopyranosylbenzoic acid; D000998:Antiviral Agents; D005960:Glucosides; D012459:Salicylates