Amygdala lesions block the effect of cocaine on memory in mice.
Post-training cocaine intraperitoneal administration enhanced memory consolidation in unoperated and sham-lesioned mice tested in a one-trial inhibitory avoidance task. Bilateral electrolytical amygdala lesions blocked this effect. The results are interpreted in terms of involvement of neurotransmitter, and in particular dopaminergic, systems in the effects of cocaine on memory.
Cestari
V
V
Dipartimento di Genetica e Biologia Molecolare, Università degli Studi di Roma La Sapienz, Italy.
Mele
A
A
Oliverio
A
A
Castellano
C
C
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time / Q000187:drug effects*
D003042:Cocaine