[Clinical effects of bisoprolol in congestive heart failure due to dilated cardiomyopathy].
Bisoprolol was administered orally at doses of 1.25-5 (mean 3.2 +/- 1.1)mg/day for 3-10 (mean 4.1 +/- 1.6) months in 19 patients with congestive heart failure secondary to dilated cardiomyopathy. All patients heart rate and blood pressure were sensitive to the first dose 1.25 mg bisoprolol and when the dose was titrated to 2.5 mg, it was effective and led to a smooth course during a 10-hour period of observation. After treatment, the patients heart function, including fractional shortening, ejection fraction and exercise ability increased significantly and both the severity and the incidence of ventricular arrhythmias decreased significantly. The response of heart rate to exercise and isoproterenol infusion tended to be normal lymphocyte beta-adrenergic receptor density was increased. It is shown that bisoprolol is a promising beta-blocking agent in treating congestive heart failure. The mechanisms of its effects may be related to depression of excessive sympathetic activity, decrease of heart rate and up-regulation of beta-adrenergic receptor.
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Division of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing.
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D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D017298:Bisoprolol / Q000008:administration & dosage / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D003864:Depression, Chemical; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged
D000319:Adrenergic beta-Antagonists; D017298:Bisoprolol