Effects of haloperidol and chlorpromazine on smooth muscle contractility, platelet aggregation and neuronal calcium current.
Effects of chlorpromazine, haloperidol (neuroleptics and calmodulin antagonists), and verapamil on rat platelet aggregation induced by thrombin, on calcium current in snail neurones and on both tonic tension of high potassium contracture and phasic contraction of isolated guinea-pig ureter preparations were studied. Moreover, droperidol, sulpiride and prazosine effects were studied for models of phasic contractility and platelet aggregation. Sulpiride and prazosine were ineffective, verapamil was ineffective on platelet aggregation, while droperidol was the most potent inhibitor of platelet aggregation. These results, the similarity revealed in the blockage of neuronal calcium current by neuroleptics and verapamil, and the potent inhibitory action of haloperidol and chlorpromazine on contractility and aggregation suggest that both phenothiazine and butyrophenone neuroleptics possess some properties of calcium antagonists and may also have intracellular sites of action other than calmodulin.
Prokopenko
R A
RA
Biomedical Department, National Academy of Sciences of Ukraine.
Mogilevich
S E
SE
Luik
A I
AI
Naydyenova
I Y
IY
Batrak
G N
GN
Hawryluk
B R
BR
Degtiar
V Y
VY
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002090:Butyrophenones / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002746:Chlorpromazine / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D006220:Haloperidol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010640:Phenothiazines / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012908:Snails; D013469:Sulpiride / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D014513:Ureter; D014700:Verapamil / Q000494:pharmacology
D014150:Antipsychotic Agents; D002090:Butyrophenones; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002147:Calmodulin; D010640:Phenothiazines; D010975:Platelet Aggregation Inhibitors; D013469:Sulpiride; D014700:Verapamil; D013917:Thrombin; C031637:phenothiazine; D006220:Haloperidol; D004329:Droperidol; D002746:Chlorpromazine; D011224:Prazosin