Effects of 6-Hydroxydopamine on the antibody response to the hapten dinitrophenyl in the chicken.
Antibody responses to the hapten dinitrophenyl (DNP) and the concentration of catecholamine in chickens received a single injection of 6-Hydroxydopamine (6-OHDA) into the chorioallantoic cavity at the embryonal stage were evaluated. A significantly enhanced anti-DNP IgA response and a markedly decreased level of noradrenaline in the peripheral blood were observed in chickens treated with 400 micrograms of 6-OHDA at 14 days of incubation. These results suggested the immunomodulatory influence of the sympathetic nervous system.
Yasuda
M
M
Laboratory of Immune Cytology, National Institute of Animal Health, Ibaraki, Japan.
Furusawa
S
S
Satoh
A
A
Taura
Y
Y
Nakama
S
S
Yoshihara
K
K
Hirota
Y
Y
D019297:2,4-Dinitrophenol; D000482:Allantois / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002642:Chick Embryo; D002645:Chickens; D002823:Chorion / Q000276:immunology; D004140:Dinitrophenols / Q000276:immunology; D004298:Dopamine / Q000097:blood*; D006241:Haptens; D007070:Immunoglobulin A / Q000096:biosynthesis*; D009638:Norepinephrine / Q000097:blood*; D016627:Oxidopamine / Q000494:pharmacology*; D013997:Time Factors
D004140:Dinitrophenols; D006241:Haptens; D007070:Immunoglobulin A; D016627:Oxidopamine; D019297:2,4-Dinitrophenol; D004298:Dopamine; D009638:Norepinephrine