title: Multiple keratoacanthomas, giant keratoacanthoma and keratoacanthoma centrifugum marginatum: development in a single patient and treatment with oral isotretinoin.
abstract: A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybridisation revealed no human papilloma virus in the tumours. Complete examination showed no associated internal malignancy. After repeated surgical treatment oral isotretinoin treatment was administered (1 mg/kg per day). This treatment produced clearing of existing keratoacanthomas and, during a period of 2 months, further keratoacanthoma formation was completely suppressed. Treatment was stopped after 3 months by the patient because of side-effects. Numerous keratoacanthomas developed during the following 6 weeks.
authors.affiliation: Department of Dermatology, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schaller
authors.forename: H C
authors.initials: HC
authors.lastname: Korting
authors.forename: H
authors.initials: H
authors.lastname: Wolff
authors.forename: C G
authors.initials: CG
authors.lastname: Schirren
authors.forename: W
authors.initials: W
authors.lastname: Burgdorf
mesh_terms: D000284:Administration, Oral; D005500:Follow-Up Studies; D006225:Hand / Q000473:pathology; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007636:Keratoacanthoma / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008046:Lip / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013909:Thorax / Q000187:drug effects / Q000473:pathology
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin