A metabolic syndrome in whites and African-Americans. The Atherosclerosis Risk in Communities baseline study.
OBJECTIVE
To describe clustering of hypertriglyceridemia, low HDL cholesterol, hypertension, diabetes, and hyperuricemia and its association with fasting insulin, waist-to-hip ratio (WHR), and BMI for African-American and white men and women.


METHODS
Observed frequencies of clusters were compared with those expected in 14,481 participants, 45-64 years of age, of the Atherosclerosis Risk in Communities (ARIC) baseline survey, 1987-1989. Associations of clusters with insulin, central adiposity, and overall obesity, as well as with abnormalities, were analyzed through multiple logistic regression.


RESULTS
Clustering beyond chance was observed in all four sex/ethnic groups (P < 0.001), with 7% of the sample presenting 30% of the abnormalities in large clusters (> or = 3 abnormalities per individual). The odds ratio (OR) for the association of each abnormality with clustering of the remaining four ranged from 1.6 to 8.8 (P < 0.01). These odds of clustering were notably large in white women. Of the abnormalities, hypertriglyceridemia demonstrated the highest OR (5.0-8.8) and diabetes had the lower OR in African-American subjects than in white subjects (P < 0.001). Insulin, WHR, and BMI were statistically associated with clustering in all groups (P < 0.001, except for BMI in African-Americans.
Schmidt
M I
MI
Department of Social Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. bbduncan2@vortex.ufrgs.br
Duncan
B B
BB
Watson
R L
RL
Sharrett
A R
AR
Brancati
F L
FL
Heiss
G
G
D001161:Arteriosclerosis / Q000453:epidemiology* / Q000517:prevention & control; D044383:Black People; D008076:Cholesterol, HDL / Q000097:blood; D016000:Cluster Analysis; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015228:Hypertriglyceridemia / Q000453:epidemiology*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D011336:Probability; D012307:Risk Factors; D012727:Sex Characteristics; D014481:United States / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood; D044465:White People; D001741:Black or African American
D008076:Cholesterol, HDL; D007328:Insulin; D014527:Uric Acid