Involvement of mercury in platelet aggregation--probable mechanism of action.
Both in vivo and in vitro Hg2+ caused dose dependent inhibition of rat platelet aggregation. However, as low a dose as 88.8 pM Hg2+ could initiate ADP-induced aggregation even in the absence of added calcium. The action of Hg2+ was found to be unaffected by antagonists such as cAMP and theophylline either alone or in combination. Hg2+ induced platelet aggregation was inhibited completely by pre-incubation with aspirin (1 mmol.L-1), but it was ineffective when added after Hg2+. The results also indicate that the normal platelet function is affected by both high and low concentrations of Hg2+.
Chaudhury
S
S
Department of Zoology, Visva Bharati University, Santiniketan, India.
Mukhopadhyay
B
B
Bose
S
S
Bhattacharya
S
S
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D008297:Male; D008627:Mercuric Chloride / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013806:Theophylline / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D010726:Phosphodiesterase Inhibitors; D010975:Platelet Aggregation Inhibitors; D008627:Mercuric Chloride; D000244:Adenosine Diphosphate; D013806:Theophylline; D000242:Cyclic AMP; D001241:Aspirin