title: A special form of cerebral lacunae: expanding lacunae.
abstract: The case of a 42 year old man with headache, blurred vision, and diplopia allowed the description of a particular form of cerebral lacunae-that is, expanding lacunae. Brain MRI showed hydrocephalus and multiple lesions in the thalamomesencephalic region. The radiological features of these lesions were similar to the histological brain coronal section of a case reported in 1983 in which expanding lacunae were related to a dilatation of the perivascular spaces and a focal segmental necrotising angiitis. The role of the lymphatic drainage of the brain is discussed to explain the dilatation of the perivascular spaces. The hypothesis of a hydrodynamic factor being responsible for the expanding character of the lacunae was suggested by the location of the lesions and the influence of various clinical events on the symptomatology.
authors.affiliation: Department of Neurology, Hôpital de la Salpêtrière, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Homeyer
authors.forename: P
authors.initials: P
authors.lastname: Cornu
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: J
authors.initials: J
authors.lastname: Chiras
authors.forename: C
authors.initials: C
authors.lastname: Derouesné
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000473:pathology; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000503:physiopathology* / Q000601:surgery; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery