Cathepsin-D and TNF-alpha in bladder cancer.
In a study of 34 normal healthy controls, 35 patients with urinary tract bilharziasis and 93 bladder cancer patients (62 of them are operable cases and 31 are non-operable ones), serum tumor necrosis factor alpha (TNF-alpha) and cytosolic Cathepsin-D were estimated. Though both potential markers were elevated in bladder cancer patients, neither Cathepsin-D nor TNF-alpha showed associations of prognostic value since there were no positive correlations with tumor stages, grades or association of tumors with bilharzial ova or lymph node involvement.
Salman
T
T
Tumor Marker Oncology Research Centre, Al-Azhar University, NasrCity, Cairo, Egypt.
el-Ahmady
O
O
el-Shafee
M
M
Omar
S
S
Salman
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D002402:Cathepsin D / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012553:Schistosomiasis haematobia / Q000378:metabolism; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D001743:Urinary Bladder / Q000201:enzymology; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
D014408:Biomarkers, Tumor; D014409:Tumor Necrosis Factor-alpha; D002402:Cathepsin D