title: Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.
abstract: OBJECTIVE
  We investigated the role of Tamm-Horsfall protein in interstitial cystitis.
  
  
  METHODS
  Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein.
  
  
  RESULTS
  Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases.
  
  
  CONCLUSIONS
  The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.
authors.affiliation: Department of Urology, University Hospital Groningen, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bade
authors.forename: J
authors.initials: J
authors.lastname: Marrink
authors.forename: A
authors.initials: A
authors.lastname: Karrenbeld
authors.forename: L
authors.initials: L
authors.lastname: van der Weele
authors.forename: H J
authors.initials: HJ
authors.lastname: Mensink
mesh_terms: D000328:Adult; D000368:Aged; D018856:Cystitis, Interstitial / Q000209:etiology / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000652:urine*; D011446:Prospective Studies; D058949:Uromodulin
chemical_list: D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin