title: Acquired free protein S deficiency in children with steroid resistant nephrosis.
abstract: Plasma and urine concentrations of protein S were measured in five children with steroid-resistant nephrotic syndrome. It was found that plasma free protein S was reduced in three out of the five patients studied. Thus, acquired free protein S deficiency does occur in children with nephrotic syndrome and is one of many factors which may place them at risk for a thromboembolic event.
authors.affiliation: Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Hanevold
authors.forename: J
authors.initials: J
authors.lastname: Lazarchick
authors.forename: M A
authors.initials: MA
authors.lastname: Constantin
authors.forename: K L
authors.initials: KL
authors.lastname: Hiott
authors.forename: J K
authors.initials: JK
authors.lastname: Orak
mesh_terms: D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000378:metabolism; D017293:Protein S / Q000032:analysis* / Q000652:urine; D018455:Protein S Deficiency / Q000209:etiology* / Q000378:metabolism; D011507:Proteinuria / Q000209:etiology; D012307:Risk Factors; D013256:Steroids / Q000494:pharmacology*; D013923:Thromboembolism / Q000209:etiology
chemical_list: D017293:Protein S; D013256:Steroids; D003404:Creatinine