Brain effect of intracarotid administration of cisplatinum.
The antitumoral effect of Cisplatinum is well known, including its effect on brain tumors. With the purpose of establishing the effect of intraarterial cis-dichlorodiammine platinum (CDDP) on the brain, Cisplatinum was injected in rabbits that were sacrificed at different intervals. The general clinical and neurological condition of the rabbits was unaffected, and histopathological examination of the rabbit's brain was normal.
Schiffer
J
J
Department of Neurosurgery and Oncology, Assaf Harofeh Medical Center, Zerifin, Israel.
Walach
N
N
Nyska
A
A
Lushkov
G
G
Rothman
S
S
Pollak
L
L
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D002339:Carotid Arteries; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D011817:Rabbits; D013997:Time Factors
D000970:Antineoplastic Agents; D002945:Cisplatin