Lack of dietary calcium effect on chlordecone increased white blood cell count, total iron, and iron-binding capacity in serum of rat.
Male Sprague-Dawley rats were treated with 0, 1, 10, 50, and 100 ppm of chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. The control rats fed with Ca-D diet exhibited a significant increase in white blood cell (WBC) counts compared to the rats fed with Ca-S diet. Dietary calcium (Ca), however, did not elicit any significant effect on total iron content and iron-binding capacity (transferrin) of control rats, whereas Cd at higher concentrations significantly increased WBC counts, total iron, and iron-binding capacity in serum of both Ca-S and Ca-D rats. The data suggest that dietary Ca did not alter Cd-increased WBC count, total iron, and iron-binding capacity in serum of rat.
Chetty
K N
KN
Department of Biological Sciences, Grambling State University, Louisiana 71245, USA.
Fantroy
L
L
Landau
G
G
Ivie
G W
GW
D000818:Animals; D002118:Calcium / Q000172:deficiency*; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D007631:Chlordecone / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000633:toxicity*; D007501:Iron / Q000097:blood*; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014168:Transferrin / Q000187:drug effects / Q000378:metabolism
D002136:Calcium, Dietary; D007306:Insecticides; D014168:Transferrin; D007501:Iron; D007631:Chlordecone; D002118:Calcium