[Anti-promoting and anti-mutagenic actions of G9315].
G9315, a complex extracted from Glycyrrhizae inflata Bat (III), consists of 6 flavonoids with significant antioxidant effects. At 1 mg dose it inhibited the mouse ear edema induced by croton oil, and showed strong anti-promoting effects on two-stage carcinogenesis in mouse skin induced by DMBA plus croton oil. The TPA enhanced 32Pi-incorporation into phospholipid fraction in HeLa cells was inhibited, and the micronuclei in mouse bone marrow cells induced by cytoxan was also depressed.
Fu
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N
Cancer Institute, CAMS and PUMC, Beijing.
Liu
Z
Z
Zhang
R
R
D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003436:Croton Oil; D004427:Ear Diseases / Q000139:chemically induced / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D051379:Mice; D015162:Micronucleus Tests; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology*; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*
D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D005419:Flavonoids; C098590:G9315; D003436:Croton Oil