[Plasma prostacyclin (PGI2) levels in peripheral venous, arterial and portal venous blood in cirrhotic patients with portal hypertension and their clinical implication].
Plasma levels of PGI2 were measured by radioimmunoassay in 20 consecutively admitted cirrhotic patients with portal hypertension from Aug. 1993 to Aug. 1994. It was found that cirrhotic patients with portal hypertension had much higher portal venous PGI2 levels than controls (528.25 +/- 205.48ng/L vs. 235.73 +/- 49.36ng/L, P < 0.001). Portal venous PGI2 levels in patients with cirrhosis and portal hypertension correlated significantly with portal venous pressure (r = 0.60, P < 0.05). The results indicate that increased portal venous PGI2 levels may have a role in maintenance of established portal hypertensive state in cirrhotic patients with portal hypertension.
Yin
J
J
People's Hospital, Beijing Medical University.
Leng
X
X
Zhu
J
J
D000328:Adult; D000368:Aged; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood* / Q000188:drug therapy; D007213:Indomethacin / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure / Q000187:drug effects; D011169:Portal Vein
D016861:Cyclooxygenase Inhibitors; D011464:Epoprostenol; D007213:Indomethacin