Aclacinomycin X, a novel anthracycline antibiotic produced by Streptomyces galilaeus ATCC 31133.
A new anthracycline antibiotic, designated as aclacinomycin X, was isolated from the culture broth of Streptomyces galilaeus ATCC 31133, and was identified as 7-(O-rhodosaminyl-deoxyfucosyl-rednosyl)- aklavinone. Its in vitro cytotoxicity was tested against several human tumor cell lines.
Kim
H S
HS
Microbial Chemistry Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea.
Kim
Y H
YH
Yoo
O J
OJ
Lee
J J
JJ
D015250:Aclarubicin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D003470:Culture Media; D006801:Humans; D007938:Leukemia / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000473:pathology; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
C099664:11-hydroxyaclacinomycin X; D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D003470:Culture Media; C011157:aclacinomycins; D015250:Aclarubicin