title: The use of gadolinium-BOPTA on magnetic resonance imaging in brain infection.
abstract: OBJECTIVE
  The use of gadolinium (Gd)-BOPTA as a magnetic resonance contrast agent for central nervous system disease was studied in a canine brain abscess model.
  
  
  METHODS
  A Streptococcus faecalis brain abscess was evaluated in five dogs at 1.5T. Imaging was performed during the late cerebritis stage, at 5 to 7 days after surgery. Magnetic resonance scans were acquired before and at 1, 5, 15, 30, 45, and 60 minutes after contrast administration, using a dose of 0.1 mmol/kg. Scans also were acquired both before and after contrast injection with the implementation of magnetization transfer.
  
  
  RESULTS
  Lesion enhancement, quantified by region-of-interest measurement, peaked at 5 minutes after contrast injection. Both the increase in lesion enhancement from 1 to 5 minutes after injection and the decrease from 5 to 15 minutes after injection, although small, were statistically significant (P < 0.004 and P < 0.03, respectively). The application of magnetization transfer improved lesion enhancement, as measured by signal difference/noise, by 39%. This result also was statistically significant (P < 0.001).
  
  
  CONCLUSIONS
  In intraparenchymal brain infection, Gd-BOPTA provides effective lesion enhancement when used at a dose of 0.1 mmol/kg. Further research is needed to compare the magnitude of enhancement achieved with Gd-BOPTA, which has weak protein binding and both hepatobiliary and renal excretion, with that with Gd chelates, which have pure renal excretion.
authors.affiliation: Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington 40536-0098, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: J W
authors.initials: JW
authors.lastname: Wells
authors.forename: N M
authors.initials: NM
authors.lastname: Williams
authors.forename: J F
authors.initials: JF
authors.lastname: Timoney
authors.forename: C
authors.initials: C
authors.lastname: Lee
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001922:Brain Abscess / Q000175:diagnosis* / Q000382:microbiology; D003287:Contrast Media; D004195:Disease Models, Animal; D004285:Dogs; D013293:Enterococcus faecalis; D005682:Gadolinium; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium