A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease.
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
Ramachandran
G
G
Gertrude H. Sergievsky Center, New York, NY 10032, USA.
Marder
K
K
Tang
M
M
Schofield
P W
PW
Chun
M R
MR
Devanand
D P
DP
Stern
Y
Y
Mayeux
R
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D001057:Apolipoproteins E