title: [Changes of lung volumes and respiratory muscle strength in patients with growth hormone deficiency].
abstract: The relationship between growth hormone deficiency (GHd) and ventilatory function is not well understood. We studied 7 patients with GHd since childhood who had been adequately treated with replacement therapy until cartilage fusion. Together with 7 well-matched (age and body-type) healthy control subjects, they underwent spirometry including determination of residual volume, and lung diffusing capacity. Also recorded were maximal respiratory muscle pressure during inspiration (PImax) and expiration (PEmax). Patients with GHd showed a significant reduction in total lung capacity and vital capacity while residual volume and lung diffusing capacity remained unchanged. All patients had a significant reduction of both PImax and PEmax. Previously treated adult subjects with GHd present a persistent decrease in lung mobilizing volumes associated with reduced respiratory muscle strength. These alterations may have implications in the management of GHd in adult patients.
authors.affiliation: Cattedra di Malattie dell'Apparato Respiratorio, Università degli Studi Federico II di Napoli.
authors.forename: M
authors.initials: M
authors.lastname: Sofia
authors.forename: L
authors.initials: L
authors.lastname: Carratù
authors.forename: B
authors.initials: B
authors.lastname: Merola
authors.forename: M
authors.initials: M
authors.lastname: Mormile
authors.forename: S
authors.initials: S
authors.lastname: Longobardi
authors.forename: A
authors.initials: A
authors.lastname: Stanziola
authors.forename: A
authors.initials: A
authors.lastname: Molino
authors.forename: A
authors.initials: A
authors.lastname: Micco
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D012119:Respiration / Q000502:physiology; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000503:physiopathology*
chemical_list: D013006:Growth Hormone
vernacular_title: Modificazioni dei volumi polmonari e della forza muscolare respiratoria in pazienti con deficit dell'ormone della crescita.