title: A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease.
abstract: We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
authors.affiliation: Gertrude H. Sergievsky Center, New York, NY 10032, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ramachandran
authors.forename: K
authors.initials: K
authors.lastname: Marder
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.forename: P W
authors.initials: PW
authors.lastname: Schofield
authors.forename: M R
authors.initials: MR
authors.lastname: Chun
authors.forename: D P
authors.initials: DP
authors.lastname: Devanand
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D001057:Apolipoproteins E