title: [Lung lesion in acute pancreatitis].
abstract: Clinically detectable signs of lung injury develop in up to 70 percent of patients with acute pancreatitis. In order to study the pulmonary injury, experimental haemorrhagic pancreatitis was induced in 63 Wistar rats by intraductal injection of 5 per cent sodium taurocholate. Investigations were carried out 2, 4, 6, 12, 24 and 48 hours after the end of pancreatitis induction. Lung injury was maximal at 12 hours after pancreatitis induction, pancreatic enzymes (amylase and trypsin) in peritonial fluid were maximal early (2-4h) and serum levels were maximal at about 4 hours after induction. In conclusion, in experimental acute pancreatitis pulmonary injury occurs 12 h after the start of infusion with increase in vascular permeability of the lung. This lesion may be related to pancreatic enzymes in peritonial fluid and blood.
authors.affiliation: Departamento de Gastroenterologia, Universidade de São Paulo.
authors.forename: A
authors.initials: A
authors.lastname: Alves Júnior
authors.forename: S N
authors.initials: SN
authors.lastname: Sampietre
authors.forename: A M
authors.initials: AM
authors.lastname: de Mendonça Coelho
authors.forename: M
authors.initials: M
authors.lastname: Saldanha Kubrusly
authors.forename: N A
authors.initials: NA
authors.lastname: Trindade Molan
authors.forename: M C
authors.initials: MC
authors.lastname: Cesar Machado
authors.forename: H W
authors.initials: HW
authors.lastname: Pinotti
mesh_terms: D000208:Acute Disease; D000818:Animals; D001202:Ascitic Fluid / Q000201:enzymology; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D010195:Pancreatitis / Q000097:blood / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
vernacular_title: Lesão pulmonar na pancreatite aguda.