title: Quantitative determination of immunological components of salivary gland secretion in transplant recipients.
abstract: Cancer therapies often induce oral complications. We studied longitudinally the major salivary immunoglobulin content in 42 transplant recipients using an enzyme-linked immunosorbent assay. A dramatic decrease in both sIgA and IgG is noticed post-transplant compared to pretransplant values. Only a small recovery of these immunoglobulin concentrations is seen after approximately 4 months. The reduction of sIgA and IgG in saliva could contribute to the frequent oral complications seen in these patients after transplantation and increase the risk of developing dental caries.
authors.affiliation: Department of Dentistry, Free University of Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Dens
authors.forename: M
authors.initials: M
authors.lastname: Boogaerts
authors.forename: P
authors.initials: P
authors.lastname: Boute
authors.forename: D
authors.initials: D
authors.lastname: Declerck
authors.forename: H
authors.initials: H
authors.lastname: Demuynck
authors.forename: F
authors.initials: F
authors.lastname: Vinckier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D012463:Saliva / Q000276:immunology*; D012469:Salivary Glands / Q000378:metabolism*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G