Peripheral sensory disturbances related to treatment with fluoroquinolones.
The symptoms and possible risk factors of peripheral sensory disturbances related to fluoroquinolones are reviewed on the basis of 37 reports submitted to the Swedish Adverse Drug Reactions Advisory Committee. In 25 patients (68%), symptoms occurred within 1 week after start of treatment. Paraesthesia was the most common complaint and occurred in 81% of the cases. Fifty-one per cent of the reports concerned numbness/hypoaesthesia, 27% pain/hyperaesthesia and 11% muscle weakness. Seventy-one per cent of the patients recovered within 2 weeks after drug discontinuation. Possible predisposing factors were impaired renal function, diabetes, lymphatic malignancy and treatment with another drug known to cause neuropathy.
Hedenmalm
K
K
Division of Clinical Pharmacology, Norrland University Hospital, Sweden.
Spigset
O
O
D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D013548:Sweden
D000890:Anti-Infective Agents; D024841:Fluoroquinolones