[The hepatoprotective and cholagogic action of glycyrrhizic acid derivatives].
The experiments on rats with toxic hepatic damage induced by tetrachloromethane have shown that the derivatives of glycyrrhizinic acid (5NGA) promote a decrease in the rate of lipid peroxide oxygenation in the hepatic tissue homogenate and the blood serum, in the inhibition of organospecific enzyme activity (BHMT, ALT, AST) and increase in choleresis. The data obtained testify to the hepatoprotective activity of the derivatives of glycyrrhizinic acid.
Nasyrov
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KhM
Chepurina
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Kireeva
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D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019695:Glycyrrhizic Acid; D008099:Liver / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000627:therapeutic use; D013997:Time Factors
D002756:Cholagogues and Choleretics; D005419:Flavonoids; D010936:Plant Extracts; D012838:Silymarin; C061938:silibor; D019695:Glycyrrhizic Acid; D011239:Prednisolone; D006034:Glycyrrhetinic Acid
Izuchenie gepatoprotektornogo i zhelchegonnogo deĭstviia proizvodnykh glitsirrizinovoĭ kisloty.