title: Language comprehension profiles in Alzheimer's disease, multi-infarct dementia, and frontotemporal degeneration.
abstract: We assessed language functioning in 116 age-, education-, and severity-matched patients with the clinical diagnosis of Alzheimer's disease (AD), multi-infarct dementia (MID) due to small-vessel ischemic disease, or a frontotemporal form of degeneration (FD). Assessments of comprehension revealed that patients with AD are significantly impaired in their judgments of single word and picture meaning, whereas patients with FD had sentence comprehension difficulty due to impaired processing of grammatical phrase structure. Patients with MID did not differ from control subjects in their comprehension performance. Traditional aphasiologic measures did not distinguish between AD, MID, and FD. Selective patterns of comprehension difficulty in patients with different forms of dementia emphasize that language deficits cannot be explained entirely by the compromised memory associated with a progressive neurodegenerative illness.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA.
authors.forename: M
authors.initials: M
authors.lastname: Grossman
authors.forename: M
authors.initials: M
authors.lastname: D'Esposito
authors.forename: E
authors.initials: E
authors.lastname: Hughes
authors.forename: K
authors.initials: K
authors.lastname: Onishi
authors.forename: N
authors.initials: N
authors.lastname: Biassou
authors.forename: T
authors.initials: T
authors.lastname: White-Devine
authors.forename: K M
authors.initials: KM
authors.lastname: Robinson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D000704:Analysis of Variance; D001927:Brain Diseases / Q000523:psychology*; D015161:Dementia, Multi-Infarct / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D007802:Language; D008297:Male; D013702:Temporal Lobe