title: A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis.
abstract: The hormone abscisic acid (ABA) modulates a variety of developmental processes and responses to environmental stress in higher plants. A collection of mutations, designated era, in Arabidopsis thaliana that confer an enhanced response to exogenous ABA includes mutations in the Era1 gene, which encodes the beta subunit of a protein farnesyl transferase. In yeast and mammalian systems, farnesyl transferases modify several signal transduction proteins for membrane localization. The era1 mutants suggest that a negative regulator of ABA sensitivity must be acted on by a farnesyl transferase to function.
authors.affiliation: Department of Botany, University of Toronto, 25 Willcocks Street, Toronto, Canada, M5S 3B2.
authors.forename: S
authors.initials: S
authors.lastname: Cutler
authors.forename: M
authors.initials: M
authors.lastname: Ghassemian
authors.forename: D
authors.initials: D
authors.lastname: Bonetta
authors.forename: S
authors.initials: S
authors.lastname: Cooney
authors.forename: P
authors.initials: P
authors.lastname: McCourt
mesh_terms: D000040:Abscisic Acid / Q000494:pharmacology*; D019883:Alkyl and Aryl Transferases; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D017343:Genes, Plant; D018525:Germination; D008969:Molecular Sequence Data; D009154:Mutation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism; D012639:Seeds / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D016415:Sequence Alignment; D015398:Signal Transduction; D014166:Transferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D018749:RNA, Plant; D000040:Abscisic Acid; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase