[The effect of 2',5'-oligoadenylates on the expression of the cellular proto-oncogene c-myc during the development of Svec's leukemia in rats].
The effects of 2',5'-oligoadenilates (2,5A) on the survival of Wistar rats inoculated with Svec leukemia cells and the proliferation of tumoral cells were investigated. An agreement between the expression of c-myc protooncogene and inhibition of leukemic cell proliferation by 2,5A was found.
Prima
V I
VI
Kvitnitskaia
A B
AB
Glushakova
L G
LG
Tarasenko
P D
PD
Stogniĭ
A B
AB
Seniuk
O F
OF
Platonov
O M
OM
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects* / Q000235:genetics; D007942:Leukemia, Experimental / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D009368:Neoplasm Transplantation; D009843:Oligoribonucleotides / Q000494:pharmacology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000187:drug effects* / Q000235:genetics; D012334:RNA, Neoplasm / Q000187:drug effects / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D011500:Protein Synthesis Inhibitors; D016271:Proto-Oncogene Proteins c-myc; D012334:RNA, Neoplasm; C023505:2',5'-oligoadenylate
Vliianie 2',5'-oligoadenilatov na ékspressiiu kletochnogo protoonkogena c-myc pri razvitii leĭkoza Shvetsa u krys.