title: Treatment of urinary incontinence in bitches by endoscopic injection of glutaraldehyde cross-linked collagen.
abstract: Thirty-two spayed bitches with urinary incontinence due to urethral sphincter incompetence, non-responsive to phenylpropanolamine administration, were treated by urethral submucosal injection of glutaraldehyde cross-linked collagen. Urinary incontinence resolved after a single injection in 19 of the bitches. Additional medication with phenylpropanolamine was necessary in five of these dogs, however. Of the 13 bitches that remained incontinent, the injections were repeated in nine. This resulted in a return to continence in five dogs, although two of these required additional medication for complete continence. The cure rate due to collagen injections alone is 53 per cent (17 of the 32 cases). A total of 41 injections were performed and no post-operative complications were observed.
authors.affiliation: Department of Reproduction, Faculty of Veterinary Medicine, University of Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Arnold
authors.forename: M
authors.initials: M
authors.lastname: Hubler
authors.forename: G
authors.initials: G
authors.lastname: Lott-Stolz
authors.forename: P
authors.initials: P
authors.lastname: Rüsch
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D004724:Endoscopy / Q000662:veterinary; D005260:Female; D007267:Injections / Q000662:veterinary; D013997:Time Factors; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000628:therapy / Q000662:veterinary*
chemical_list: D001672:Biocompatible Materials; C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen