title: Mechanisms of cardiovascular injury in renal disease.
abstract: Patients with renal disease have an increased cardiovascular mortality. Hyperlipidemia, a hallmark of renal disease, is recognized as a principal cause of atherosclerosis. However, it is difficult to prove a pathogenetic role of renal dyslipidemia per se in this increased cardiovascular risk since multiple risk factors are often present in patients with progressive renal insufficiency, e.g. hypertension, diabetes and hypercoagulability. However, evidence is accumulating demonstrating detrimental effects of hyperlipidemia during both initiation and progression of the atherosclerotic process. The present review discusses this evidence in patients with renal disease, and the possible implications for treatment.
authors.affiliation: Department of Nephrology and Hypertension, University Hospital, Utrecht, Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: Rabelink
authors.forename: E S
authors.initials: ES
authors.lastname: Stroes
authors.forename: H A
authors.initials: HA
authors.lastname: Koomans
mesh_terms: D001161:Arteriosclerosis / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000209:etiology*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D007674:Kidney Diseases / Q000150:complications*; D017202:Myocardial Ischemia / Q000150:complications; D012307:Risk Factors