[Influences of a shiitake (Lentinus edodes)-fructo-oligosaccharide mixture (SK-204) on experimental pulmonary thrombosis in rats].
Effects of the mixture (SK-204) consisting of dried shiitake mushroom (Lentinus edodes) treated with wet-heating and fructo-oligosaccharides (7:3) on the experimental models of pulmonary thrombosis induced by lactic acidosis in rats were evaluated. Chronic oral administration (10 weeks) of SK-204 significantly prevented the thrombus formation on this thrombosis model. However, decreases in the numbers of platelet and fibrinogen level by lactate were not changed by SK-204. These results suggest that SK-204 have an anti-thrombotic action, which is due to neither the inhibition of platelet aggregation nor coagulation, but probably due to the promotion of fibrinolysis and thrombolysis.
Otsuka
M
M
Central Research Institute, Shigaken Pharm. Ind. Co. Ltd., Shiga, Japan.
Shinozuka
K
K
Hirata
G
G
Kunitomo
M
M
D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005632:Fructose; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D010976:Platelet Count / Q000187:drug effects; D011124:Polyporaceae; D011655:Pulmonary Embolism / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
D005343:Fibrinolytic Agents; D009844:Oligosaccharides; C098616:fructo-oligosaccharide-shitake; D005632:Fructose