Transcriptional expression of Epstein-Barr virus genes and proto-oncogenes in north African nasopharyngeal carcinoma.
Cases of nasopharyngeal carcinoma (NPC) from North Africa show an unusual bimodal age distribution. As elsewhere, the tumor is closely associated with the presence of Epstein-Barr virus (EBV). The expression of EBV genes and c-onc genes was studied in biopsy specimens from tumors at different clinical stages from 11 young (10 to 30-year-old) and 11 adult (30 to 65-year-old) patients. It was found that the two age groups do not differ in their pattern of gene expression, that there is a tendency for later stage biopsies to express more viral and c-onc transcripts, and that samples expressing larger numbers of EBV genes also tend to express many different c-onc specificities.
Sbih-Lammali
F
F
Laboratoire de Virologie Moléculaire, CNRS, Faculté de Médecine Alexis Carrel, Lyon, France.
Djennaoui
D
D
Belaoui
H
H
Bouguermouh
A
A
Decaussin
G
G
Ooka
T
T
D000293:Adolescent; D000328:Adult; D000352:Africa, Northern; D000368:Aged; D000375:Aging; D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000821:virology*; D002460:Cell Line; D002648:Child; D018628:Gene Dosage; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000821:virology*; D011519:Proto-Oncogenes; D014158:Transcription, Genetic