[Effect of kanggusong in prevention and treatment of retinoic acid induced osteoporosis in rats].
Retinoic acid 70 mg/kg.d was given by gastrogavage to Wistar rat for 14 days to induce osteoporosis. Kanggusong (KGS), a mixture of extracts from 8 traditional Chinese drugs, was given to 3 test groups of rats simultaneously in various dosage. Results showed that the KGS displayed obvious action in preventing osteoporosis, the trabecular loss of tibiae and bone loss of compact bone were lowered markedly in KGS groups with high (3.0 g/kg.d) or middle (1.0 g/kg.d) dosage in comparing with control model group, the trabecular area percentage and compact bone area percentage were increased significantly (P < 0.05) which approached to the level of normal control group. KGS could also improve the pathological changes in microstructure of bone, increase the thickness of trabecula and cortex (P < 0.05), reduce the trabecular gap and bone marrow cavity (P < 0.05). The mechanism of KGS might be relevant with its action of suppressing the osteoclast activity and activating osteoblast, resulting a positive balance of bone metabolism, increasing the blood concentration of calcium and estrogen as well as its antagonistic action against the injury of sex glands by retinoic acid.
Wu
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B
Dept. of Pharmacoeogy, Medical and Pharmaceutical Research Institute of 999 Enterprise Group, Guangdong.
Xu
B
B
Huang
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D000818:Animals; D001862:Bone Resorption; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*; D010125:Ostreidae; D051381:Rats; D017208:Rats, Wistar; D014212:Tretinoin
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D014212:Tretinoin