Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.
In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carinii pneumonia.
Merali
S
S
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016, USA.
Chin
K
K
Grady
R W
RW
Clarkson
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AB
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003676:Deferoxamine / Q000097:blood* / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology; D011010:Pneumocystis / Q000187:drug effects* / Q000502:physiology; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000382:microbiology; D051381:Rats
D000935:Antifungal Agents; D003676:Deferoxamine