[A pharmacological analysis of the antiedematous action of GABA-ergic and opioidergic agents in craniocerebral trauma].
Experiments on rats with skull inquiry show that biculline (dose 2 mg/kg) removes antiedematous effect of fenibut (50 mg/kg), sodium hydroxybutirate (200 mg/kg), promedol (1 mg/kg), and synthetic analogs of encephalines DAGO and DSLET (100 mg/kg). Naloxon at a dose 1 mg/kg blocks antiedematous effect of ligands of opiate receptors, but does not change the effect of fenibut and sodium hydroxybutirate. The presence of close inter-regulatory interactions between GAMK-ergic and opioidergic systems in forming the traumatic correction is suggested.
Novikov
V E
VE
Iasnetsov
V V
VV
D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004745:Enkephalins / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D018682:GABA Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018756:GABA Antagonists / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D011396:Promedol / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000701:Analgesics, Opioid; D004745:Enkephalins; D018682:GABA Agents; D018756:GABA Antagonists; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009270:Naloxone; D005680:gamma-Aminobutyric Acid; D004743:Enkephalin, Leucine; D011396:Promedol; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; D012978:Sodium Oxybate; C008842:4-amino-3-phenylbutyric acid; D001640:Bicuculline
Farmakologicheskiĭ analiz protivootechnogo deĭstviia GAMK- i opioidergicheskikh sredtsv pri cherepno-mozgovoĭ travme.