Derangement in stress response of apolipoprotein E-deficient mice.
Apolipoprotein E (apoE) is associated with familial and sporadic Alzheimer's disease (AD). Stress has been identified as a putative risk factor of AD. Thus, in the present study we examined the susceptibility of apoE-deficient mice to stress. The results obtained revealed that the elevation of corticosterone levels in apoE-deficient mice following restraint stress is markedly lower than in controls, and that these mice differ in their behavioral pain response to noxious stimuli in both stress and non-stress conditions. These findings suggest an interplay between apoE and the response to stressful stimuli and provide a model for elucidating the relationship between apoE and susceptibility to stress.
Gordon
I
I
Department of Neurobiochemistry, Tel Aviv University, Ramat Aviv, Israel.
Ben-Eliyahu
S
S
Rosenne
E
E
Sehayek
E
E
Michaelson
D M
DM
D000544:Alzheimer Disease / Q000097:blood / Q000503:physiopathology*; D000704:Analysis of Variance; D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency*; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000502:physiology; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*
D001057:Apolipoproteins E; D003345:Corticosterone