title: Aggressive CD5-positive diffuse large B cell lymphoma showing c-myc rearrangements developed in a patient with autoimmune hemolytic anemia.
abstract: A case of CD5-positive diffuse large cell lymphoma in a patient with autoimmune hemolytic anemia (AIHA) is reported. The patient was diagnosed with AIHA in December 1988. Three and a half years later, the patient complained of fever and left sided flank pain. Abnormal lymphocytes appeared in the peripheral blood and were positive for HLA-DR, CD5, CD19, CD20, and surface immunoglobulin (mu, lambda). The pathological diagnosis of the cervical lymphnode was non-Hodgkin lymphoma; diffuse large cell type with a starry sky-like appearance. Although the 8q24 translocation was not detected by karyotypic analysis of the peripheral blood mononuclear cells (PBMNC), Southern blot analysis revealed that the c-myc rearrangements had occurred. This case showed two rearranged bands with Eco RI, Bam HI, or Bgl II digestion, and a germline band with Hin dIII digestion using a second exon fragment of the c-myc gene as a probe. Despite intensive chemotherapy, this patient died 6 months after being diagnosed with malignant lymphoma. We discuss the c-myc rearrangements in this aggressive CD5-positive diffuse large B cell lymphoma.
authors.affiliation: Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sonoki
authors.forename: H
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: N
authors.initials: N
authors.lastname: Asou
authors.forename: H
authors.initials: H
authors.lastname: Hata
authors.forename: F
authors.initials: F
authors.lastname: Matsuno
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Nagasaki
authors.forename: N
authors.initials: N
authors.lastname: Kuribayashi
authors.forename: H
authors.initials: H
authors.lastname: Kudo
authors.forename: K
authors.initials: K
authors.lastname: Takatsuki
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics / Q000276:immunology*; D018956:CD5 Antigens / Q000032:analysis*; D005260:Female; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged
chemical_list: D018956:CD5 Antigens