[The effect of haloperidol at a low dose on the development of experimental parkinsonian syndrome].
Effect of galoperidole administrated in a small dose on changes in movement activity of mice in formation of hypokinetic syndrome in them using 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP) was studied. Administration of galoperidol (0.01 mg/kg) increases the stability of structures of nigro-striate system with respect to injuring effect of MPTP; galoperidol administration in the same dose after formation of hypokinetic syndrome favors the more rapid recovering movement activity of animals. One of possible mechanisms resulting in the effect mentioned above may be an increase in a number of post-synaptic receptors, induced by galoperidol administration that, in its turn, may be attributed to activation of immediate response genes.
Korshunov
A M
AM
Voronina
T A
TA
Churiukanov
V V
VV
Iakhno
N N
NN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D015259:Dopamine Agents; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D006220:Haloperidol
Vliianie galoperidola v maloĭ doze na razvitie sindroma Parkinsona v éksperimente.