Selective effects of 8-OH-DPAT on social competition in the rat.
Previous research has demonstrated that dominant-subordinate relationships measured in small groups of rats competing for access to palatable food or fluids can be disrupted by both anxiolytic and anxiogenic drugs, and it has been proposed as a possible animal model of anxiety. The present study investigated the effects of the selective 5-HT1A agonist 8-OH-DPAT on the rank order of triads of rats measured in terms of access to sweetened milk. The effect of 8-OH-DPAT on locomotor activity and intake of sweetened milk was also determined. 8-OH-DPAT (25 and 37.5 micrograms/kg) significantly increased the subordinate animals position in the social hierarchy without effect on the individual intakes of sweetened milk or locomotor activity. The same doses administered to dominant animals had no effect on any of the parameters measured. The 8-OH-DPAT-induced increase in social competition in subordinate rats was dissociable from effects on feeding behavior and locomotor activity. The results from this study provide further evidence that social competition in groups of rats may represent a model that can be used to detect drugs acting via receptor mechanisms believed to be implicated in anxiety.
Woodall
K L
KL
School of Pharmacy, University of Bradford, West Yorkshire, UK.
Domeney
A M
AM
Kelly
M E
ME
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D003163:Competitive Behavior / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D012930:Social Dominance
D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin