[The pharmacological properties of preparations from the aziridinyl triazine group].
The results of experimental studies of three drugs from aziridinyltriazine group, dioxadet, trisadet, and furizil, are presented. These drugs exhibit a pronounced therapeutic effect against a broaden spectrum of tumors grafted in mice and rats. Toxic effect of the drugs is exhibited mainly in suppression of blood formation. Other side-effects are slightly pronounced. One of the drugs, dioxadet passed the I and II stages of clinical trials and is recommended for application in chemotherapy of malignant tumors.
Stukov
A N
AN
Filov
V A
VA
Kon'kov
S A
SA
Ivin
B A
BA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002415:Cats; D004285:Dogs; D004354:Drug Screening Assays, Antitumor; D006168:Guinea Pigs; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011817:Rabbits; D051381:Rats; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D014227:Triazines; C040269:dioxadet
Farmakologicheskie svoĭstva preparatov iz gruppy aziridiniltriazinov.