Protective effect of teprenone on blood flow and incidence of histologic lesions in rat gastric mucosa after hemorrhage and retransfusion.
BACKGROUND
The effects of teprenone (6,10,14,18-tetramethyl-5,9,13, 17-nonadecatetraen-2-one) on changes in gastric mucosal blood flow, adenosine triphosphate (ATP) content, and incidence of histologic lesions were evaluated in rat gastric mucosa after hemorrhage and retransfusion.


METHODS
Teprenone (100 mg/kg) was administered orally once a day for 3 consecutive days. On the 3rd day hemorrhage was induced, withdrawn blood (retransfusion) was returned, and the above variables were determined.


RESULTS
Teprenone significantly inhibited the decreases in blood flow and index of mucosal oxygen saturation (ISO2) during hemorrhage in the corpus and antral mucosa. However, no effect of teprenone was observed on systemic blood pressure and ATP levels after hemorrhage and retransfusion. Teprenone significantly (p < 0.05) decreased both the incidence of ischemic lesions and the increase in the severity of lesions after retransfusion in both mucosal regions.


CONCLUSIONS
From these results, it is concluded that the protective effect of teprenone on blood flow was partly responsible for its inhibitory effect on the incidence of lesions in the rat stomach in this hypovolemic shock model, although the former effect might be not a direct effect on systemic vascular tone.
Hachiya
A
A
First Dept. of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
Bessho
M
M
Iwasaki
T
T
Iida
K
K
Otsuka
S
S
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001804:Blood Transfusion, Autologous; D004195:Disease Models, Animal; D004224:Diterpenes / Q000494:pharmacology*; D004734:Energy Metabolism; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006439:Hemodynamics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012769:Shock / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D000255:Adenosine Triphosphate; C031049:geranylgeranylacetone