title: Contribution of haemolysis to jaundice in Sephardic Jewish glucose-6-phosphate dehydrogenase deficient neonates.
abstract: We determined the contribution of haemolysis to the development of hyperbilirubinaemia in glucose-6-phosphate dehydrogenase (G-6-PD) deficient neonates and G-6-PD normal controls. Blood carboxyhaemoglobin (COHb), sampled on the third day of life, was measured by gas chromatography, corrected for inhaled carbon monoxide (COHbC), and expressed as a percentage of total haemoglobin concentration (Hb). Serum bilirubin was tested as clinically necessary. 37 non-jaundiced (peak serum total bilirubin (PSTB) < or = 255 mumol/l) and 20 jaundiced (PSTB > or = 257 mumol/l) G-6-PD-deficient neonates were compared to 31 non-jaundiced and 24 jaundiced controls with comparable PSTB values, respectively. COHbC values for the entire G-6-PD deficient group were higher than in the controls (0.75 +/- 0.17% v 0.62 +/- 0.19%, P < 0.001). COHbC and PSTB values did not correlate in the G-6-PD-deficient group (r = 0.15, P > 0.05) but did in the controls (r = 0.58, P < 0.001). COHbC values were increased to a similar extent in the G-6-PD-deficient, non-jaundiced (0.72 +/- 0.16%), the G-6-PD-deficient, jaundiced (0.80 +/- 0.19%) and the control, jaundiced (0.75 +/- 0.18%) subgroups, compared to the control, non-jaundiced subgroup (0.53 +/- 0.13%) (P < 0.05). Although present in G-6-PD deficient neonates, increased haemolysis was not directly related to the PSTB.
authors.affiliation: Department of Neonatology, Shaare Zedek Medical Centre, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Kaplan
authors.forename: H J
authors.initials: HJ
authors.lastname: Vreman
authors.forename: C
authors.initials: C
authors.lastname: Hammerman
authors.forename: C
authors.initials: C
authors.lastname: Leiter
authors.forename: A
authors.initials: A
authors.lastname: Abramov
authors.forename: D K
authors.initials: DK
authors.lastname: Stevenson
mesh_terms: D002248:Carbon Monoxide / Q000032:analysis; D002263:Carboxyhemoglobin / Q000032:analysis; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D006932:Hyperbilirubinemia / Q000201:enzymology / Q000209:etiology*; D007231:Infant, Newborn; D007565:Jaundice / Q000201:enzymology* / Q000209:etiology; D007585:Jews
chemical_list: D002248:Carbon Monoxide; D002263:Carboxyhemoglobin