The anti-inflammatory activity of some sulphonamides in albino rats.
Clinically equivalent doses of dapsone, sulphasalasine and sulphamethizole in albino rats showed significant (P < 0.05) anti-inflammatory activity in carrageenan and cotton pellet induced inflammation. Their activity was comparable to that of aspirin (200 mg/kg) and was confirmed by granuloma histology. Further, these compounds also showed significant (P < 0.01) analgesic activity which was comparable to that of aspirin. The ulcer index for sulphamethizole was comparable to that of control animals, whereas dapsone and sulphasalazine showed significant ulcerogenicity (P < 0.01). Other sulphonamides like sulphadiazine, sulphanilamide, sulphamoxole and cotrimoxazole did not show significant anti-inflammatory and analgesic activities.
Hiremath
S V
SV
Department of Pharmacology, J.N. Medical College, Belgaum.
Gouripur
V V
VV
Patil
P A
PA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D003622:Dapsone / Q000494:pharmacology; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013419:Sulfamethizole / Q000494:pharmacology; D012460:Sulfasalazine / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D013419:Sulfamethizole; D012460:Sulfasalazine; D003622:Dapsone; D001241:Aspirin