title: [The dose-dependent effects of a combination of different classes of antioxidants exemplified by dibunol and beta-carotene].
abstract: In order to enhance antioxidant protection of the organism in various pathological states, effective combinations of antioxidants have been developed that interact with various types of free radicals. On two experimental models,--acute alcohol intoxication and calcium chloride arrhythmia of rats, the prophylactic activity of antioxidant combinations was established for certain doses, rather then for monotherapy. The possibility of obtaining high protective effects at relatively low concentrations of the components in the complex preparation was shown. Am increase of antioxidant concentration in the preparation could decrease its efficiency. The highest efficiency in the complex preparations, as compared with in each component taken separately, was observed in the case of calcium chloride arrhythmia when dibunol and beta-carotene were combined at concentrations of 10 mg/kg and in the case of acute alcohol intoxication (1 and 0.25 mg/kg, respectively). Enhanced efficiency of combined antioxidant therapy opens up the way to the production of new active complex preparations with minimum toxic side toxic effects and complications.
authors.forename: E A
authors.initials: EA
authors.lastname: Minenkova
authors.forename: V A
authors.initials: VA
authors.lastname: Barsel'
authors.forename: V V
authors.initials: VV
authors.lastname: Pichugin
authors.forename: A B
authors.initials: AB
authors.lastname: Gagarina
authors.forename: N M
authors.initials: NM
authors.lastname: Evteeva
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Paramonova
authors.forename: G G
authors.initials: GG
authors.lastname: Maĭkova
mesh_terms: D000435:Alcoholic Intoxication / Q000517:prevention & control; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D002122:Calcium Chloride; D002338:Carotenoids / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D051381:Rats; D019207:beta Carotene
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D002084:Butylated Hydroxytoluene; D002338:Carotenoids; D002122:Calcium Chloride
vernacular_title: Dozozavisimye éffekty kombinatsii antioksidantov raznykh klassov na primere dibunola i beta-karotina.