A study of mRNA expression of glucose transporter gene in rats with diabetes mellitus.
The study was proceeded on the mRNA expression of the GLUT-1 and GLUT-4 gene in the alloxan-induced diabetic rats by the method of dot-blot hybridization analysis. The results showed that the levels of the GLUT-4 mRNA expression were reduced in the muscle tissue of the diabetic rats while its levels in the same tissue of insulin treated diabetic rats increased. It was suggested that the reduced GLUT-4 mRNA expression which could affect its posttranslational products may be one of the causes of the insulin resistance.
Wang
H
H
Department of Endocrinology, Jiangsu Province Hospital, Nanjing.
Chen
J
J
Chai
J
J
D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D009132:Muscles / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007328:Insulin; D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger