title: Effect of skin colour and selected physical characteristics on Schistosoma mansoni dependent morbidity.
abstract: The effect of the colour group on the morbidity due to Schistosoma mansoni was examined in two endemic areas situated in the State of Minas Gerais, Brazil. Of the 2773 eligible inhabitants, 1971 (71.1%) participated in the study: 545 (27.6%) were classified as white, 719 (36.5%) as intermediate and 707 (35.9%) as black. For each colour group, signs and symptoms of individuals who eliminated S.mansoni eggs (cases) were compared to those who did not present eggs in the faeces (controls). The odds ratios were adjusted by age, gender, previous treatment for schistosomiasis, endemic area and quality of the household. There was no evidence of a modifier effect of colour on diarrhea, bloody faeces or abdominal pain. A modifier effect of colour on hepatomegaly was evident among those heaviest infected (> or = 400 epg): the adjusted odds ratios for palpable liver at the middle clavicular and the middle sternal lines were smaller among blacks (5.4 and 6.5, respectively) and higher among whites (10.6 and 12.9) and intermediates (10.4 and 10.1, respectively). These results point out the existence of some degree of protection against hepatomegaly among blacks heaviest infected in the studied areas.
authors.affiliation: Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brasil.
authors.forename: C B
authors.initials: CB
authors.lastname: Cançado
authors.forename: J O
authors.initials: JO
authors.lastname: Firmo
authors.forename: S C
authors.initials: SC
authors.lastname: Fernandes
authors.forename: R S
authors.initials: RS
authors.lastname: Rocha
authors.forename: M F
authors.initials: MF
authors.lastname: Lima e Costa
mesh_terms: D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000235:genetics; D008297:Male; D009780:Occult Blood; D016017:Odds Ratio; D044469:Racial Groups; D012107:Research Design; D012555:Schistosomiasis mansoni / Q000453:epidemiology* / Q000235:genetics; D012959:Socioeconomic Factors