title: The relationship between cardiac functional capacity and patients' symptom-specific utilities for angina: some findings and methodologic lessons.
abstract: Forty-one angina patients with coronary disease were interviewed to examine the correlation between prespecified and individualized weights for disease-specific measures of the effects of angina on the patients' well-being. Modifications of the Canadian Cardiovascular Society (CCS) scale for angina and the Duke Activity Specific Index (DASI) were used to rate functional capacity with prespecified items. Disease-specific utilities based on descriptions of functional status were obtained directly, and again indirectly with different anchoring conditions to control for noncardiac comorbidity. Correlations between the functional-capacity measures and the derived utilities were not strong, ranging from -0.25 (p > 0.1) to -0.35 (p = 0.02). Correlation between the two prespecified measures was higher (r = -0.51 or -0.69, both p < 0.01, for DASI versus CCS graded from walking and stair-climbing, respectively). The direct and indirect disease-specific utility scores were similar (r = 0.92, p < 0.01). The method described provides an approach to measuring disease-specific utilities by adapting existing scales for use in a standard gamble. It confirms that prespecified functional status scores inconsistently reflect patients' valuations of functional states. Further investigation should address whether the observed null effect of comorbidity on disease-specific utilities arose from inadequate coverage of the comorbidity issues in patient interviews or from lack of power given the small size of the feasibility study.
authors.affiliation: Clinical Epidemiology Unit, Sunnybrook Health Science Centre, and the University of Toronto, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Nichol
authors.forename: H A
authors.initials: HA
authors.lastname: Llewellyn-Thomas
authors.forename: E C
authors.initials: EC
authors.lastname: Thiel
authors.forename: C D
authors.initials: CD
authors.lastname: Naylor
mesh_terms: D000203:Activities of Daily Living; D000787:Angina Pectoris / Q000453:epidemiology / Q000523:psychology*; D001294:Attitude to Health; D015897:Comorbidity; D015986:Confounding Factors, Epidemiologic; D017079:Exercise Tolerance; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index