[Evaluation of ovarian sensitivity to gonadotrophins: role of ovarian reserve tests].
Among several parameters involved in the age-dependent reduction in conception rate, intra-ovarian factors, specially the follicular oocyte complex, play a major role. The aim of endocrine challenge tests is to assess ovarian follicular reserve. Basal serum FSH determination on day 3 of the cycle is easily measurable, inexpensive. Its sensitivity is increased with a clomiphene citrate challenge test. Both GnRH agonist stimulation test and exogenous FSH test allow to evaluate more directly the ovarian function. However they are more invasive, expensive and need further standardisation.
Hugues
J N
JN
Hôpital Jean Verdier, Département de Gynécologie-Obstétrique, Université Paris XIII, Bondy.
Cédrin-Durnerin
I
I
Bulwa
S
S
Uzan
M
M
D002996:Clomiphene; D005260:Female; D005300:Fertility Agents, Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D016729:Leuprolide; D008596:Menotropins; D010050:Ovarian Function Tests / Q000379:methods*; D012680:Sensitivity and Specificity
D005300:Fertility Agents, Female; D006065:Gonadotropins, Pituitary; D002996:Clomiphene; D008596:Menotropins; D005640:Follicle Stimulating Hormone; D016729:Leuprolide
Evaluation de la sensibilité ovarienne aux gonadotrophines: place des tests de réserve ovarienne.