title: Acute lymphoblastic leukemia in a case of essential thrombocythemia.
abstract: Essential thrombocythemia is a myeloproliferative disorder that infrequently evolves into acute leukemia. Leukemic transformation is frequently preceded by therapy with alkylating agents or radioactive phosphorus (32P), and is virtually always myeloid in nature. In this report, the authors describe a case of acute lymphoblastic leukemia arising in a patient with long-standing essential thrombocythemia.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Woronzoff-Dashkoff
authors.forename: C E
authors.initials: CE
authors.lastname: Litz
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001752:Blast Crisis; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D008213:Lymphocyte Activation; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D013922:Thrombocytosis / Q000150:complications / Q000473:pathology* / Q000628:therapy
chemical_list: D015703:Antigens, CD; D010761:Phosphorus Radioisotopes; D006918:Hydroxyurea