Effects of some components of the essential oil of chamomile, Chamomilla recutita, on histamine release from rat mast cells.
The influence of three compounds of the essential oil of Chamomilla recutita (L.) Rauschert on the protamine sulphate-provoked degranulation of mast cells from Lewis-1a rats was investigated. The effect was determined by measuring histamine liberation fluorometrically. Chamazulene and (-)-alpha-bisabolol had no distinct effects. The en-yne dicycloether partly inhibited the degranulation in concentrations above 10(-4) M.
Miller
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T
Institut für Pharmazeutische Biologie, Ernst-Moritz-Arndt Universität Greifswald, Germany.
Wittstock
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U
Lindequist
U
U
Teuscher
E
E
D000818:Animals; D052176:Azulenes; D015550:Cell Degranulation; D003508:Cycloheptanes / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile / Q000737:chemistry*; D051381:Rats; D011917:Rats, Inbred Lew; D012717:Sesquiterpenes / Q000494:pharmacology*
D052176:Azulenes; D003508:Cycloheptanes; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D012717:Sesquiterpenes; C004497:bisabolol; C013872:chamazulene