title: Relationship between C14 urea breath test values and solid-phase gastric emptying time in non-ulcer dyspepsia patients.
abstract: BACKGROUND
  Non-ulcer dyspepsia (NUD) is a poorly understood syndrome often found with endoscopic evidence of gastritis; Helicobacter pylori (Hp) is a common and important cause of gastritis. In the recent literature, gastric hypomotility is thought to be a cause of NUD. Thus, this investigation studied the relationship between Hp and delayed gastric emptying in NUD patients.
  
  
  METHODS
  Using a radionuclide-labelled solid meal to calculate gastric emptying time (GET) of 78 NUD patients. The carbon-14 urea breath test (C14 UBT) was used to quantitate Hp infection.
  
  
  RESULTS
  The prevalence of Hp infection in patients with NUD reached 59%. There was a strong association of Hp infection with advanced age (p = 0.0091). There was no significant difference between solid-phase GET and C14 UBT values among three different age groups (young, middle, old) of NUD patients. There was no difference among sex, age, body weight and solid-phase GET between Hp-positive and Hp-negative NUD patients. However the solid-phase GET was significantly prolonged in patients with NUD, compared with the controls.
  
  
  CONCLUSIONS
  Solid-phase GET is not correlated with the C14 UBT values, and Hp gastric colonization does not account for dyspeptic syndrome in NUD patients.
authors.affiliation: Department of Internal Medicine, Army General Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
authors.forename: G H
authors.initials: GH
authors.lastname: Chen
authors.forename: K L
authors.initials: KL
authors.lastname: Wu
authors.forename: C S
authors.initials: CS
authors.lastname: Lay
authors.forename: C S
authors.initials: CS
authors.lastname: Chang
authors.forename: S K
authors.initials: SK
authors.lastname: Poon
authors.forename: C K
authors.initials: CK
authors.lastname: Hung
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D002250:Carbon Radioisotopes; D004415:Dyspepsia / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D014508:Urea / Q000378:metabolism
chemical_list: D002250:Carbon Radioisotopes; D014508:Urea