Hepatitogenicity of three plaque purified variants of hepatotropic mouse hepatitis virus, MHV-2 in athymic nude mice.
Hepatitogenicity of 3 plaque purified variants of hepatotropic mouse hepatitis virus, MHV-2 were examined in athymic BALB/c-nu/nu mice up to 9 weeks post infection (9WPI). All of the MHV-2S- and MHV-2M-infected mice died with severe acute hepatitis in 3WPI. On the other hand, MHV-2L-infected mice did not die until 9WPI and showed signs of slow-developing chronic hepatitis with persistent infection under low serum virus neutralizing antibody titers. This suggests that MHV-2L-infected athymic nude mice may be useful as a new model of chronic viral hepatitis.
Uetsuka
K
K
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
Nakayama
H
H
Goto
N
N
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000473:pathology / Q000821:virology*; D008099:Liver / Q000473:pathology / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D006517:Murine hepatitis virus / Q000276:immunology / Q000472:pathogenicity*
D000956:Antigens, Viral