Preliminary report: the short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas.
A pilot study, to assess the therapeutic potential of percutaneous injection of wild-type p53 (wt-p53) in five patients with primary hepatocellular carcinoma is reported. Three of the five patients showed objective tumor response with reduction of the tumor volume on computed tomographic (CT) scan measurements as well as a significant fall of serum alphafetoprotein. Much further work will be needed to elucidate the mechanism of action.
Habib
N A
NA
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
Ding
S F
SF
el-Masry
R
R
Mitry
R R
RR
Honda
K
K
Michail
N E
NE
Dalla Serra
G
G
Izzi
G
G
Greco
L
L
Bassyouni
M
M
el-Toukhy
M
M
Abdel-Gaffar
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000628:therapy*; D005334:Fever / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D008114:Liver Neoplasms, Experimental / Q000737:chemistry / Q000628:therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D008969:Molecular Sequence Data; D010865:Pilot Projects; D010957:Plasmids / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*
D016159:Tumor Suppressor Protein p53