title: [Hyperthyroidism induced by amiodarone and hyperthyroidism induced by iodine. Histologic, immunohistochemical and ultrastructural aspects].
abstract: Amiodarone is a widely-used anti-arythmic drug that induces an iodine overload and, in 1 to 23% of the patients, a thyrotoxicosis. In a few cases, the thyrotoxicosis may be refractory to conventional pharmacological therapy, thus leading to thyroidectomy. We report the thyroid gland pathology in 5 thyroidectomies that were performed for uncontrolled thyrotoxicosis, induced by amiodarone (4 cases) and by Colchimax, another iodine-rich drug (1 case). Two cases have been studied by electron microscopy. Pathologic findings were: [1] colloid transformation of the parenchyma, [2] areas of follicular disruption with numerous foamy macrophages in the colloid, [3] regenerative areas and [4] a moderate T lymphocytic infiltration. No lysosomal lamellar inclusion body was found by electron microscopy. These lesions may be rather specific of an iodine toxicity. The pathogeny is still misunderstood, and probably complex. It may essentially involve toxic mechanisms, as well as immunologic or allergic mechanisms.
authors.affiliation: Services d'Anatomie Pathologique, CHU, Angers.
authors.forename: S
authors.initials: S
authors.lastname: Guyétant
authors.forename: M C
authors.initials: MC
authors.lastname: Rousselet
authors.forename: N
authors.initials: N
authors.lastname: Wion-Barbot
authors.forename: J C
authors.initials: JC
authors.lastname: Bigorgne
authors.forename: J
authors.initials: J
authors.lastname: Victor
authors.forename: F
authors.initials: F
authors.lastname: Dupré
authors.forename: J P
authors.initials: JP
authors.lastname: Saint André
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D007150:Immunohistochemistry; D007455:Iodine / Q000009:adverse effects*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013965:Thyroidectomy
chemical_list: D000889:Anti-Arrhythmia Agents; D007455:Iodine; D000638:Amiodarone
vernacular_title: Hyperthyroïdies induites par l'amiodarone et hyperthyroïdies induites par l'iode. Aspects histologiques, immunohistochimiques et ultrastructuraux.