title: Development of a liquid chromatographic method for the control of related substances in chlorprothixene hydrochloride.
abstract: The development of a reversed-phase liquid chromatographic method, using a mobile phase containing a mixture of anion and cation ion-pairing agents and a base-deactivated octyldecylsilyl column as stationary phase, is described for the control of all known impurities in (Z)-chlorprothixene hydrochloride (bulk drug). Validation of the method showed it to be reproducible, selective for both (Z) chlorprothixene hydrochloride and its E-isomer, accurate and linear over the concentration range of analysis with a limit of detection of 0.3 microgram ml-1.
authors.affiliation: Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK.
authors.forename: G M
authors.initials: GM
authors.lastname: Duignan
authors.forename: J H
authors.initials: JH
authors.lastname: Miller
authors.forename: G G
authors.initials: GG
authors.lastname: Skellern
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry / Q000302:isolation & purification*; D002749:Chlorprothixene / Q000737:chemistry / Q000302:isolation & purification*; D002853:Chromatography, Liquid / Q000379:methods*; D008968:Molecular Conformation; D015203:Reproducibility of Results
chemical_list: D014150:Antipsychotic Agents; D002749:Chlorprothixene