[The transplacental transport and effect of morphine administered in the prenatal period on its level in adult rats].
The morphine concentration in the placenta, plasma of pregnant rats and their fetuses and in the plasma of prenatally morphinized rats was determined with HPLC method. It was found that 10 min after the intraperitoneal morphine administration at a dose of 20 mg/kg the morphine concentration in the fetus blood plasma is 3 times as large and in the placenta is 2 times as large as in the blood plasma of pregnant rats. The morphine level in prenatally morphinized rats was reliably higher than that in the control animals.
Boĭko
S S
SS
Voronina
T A
TA
Zherdev
V P
VP
Chobanov
N G
NG
D000818:Animals; D001692:Biological Transport; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005333:Fetus / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000032:analysis / Q000493:pharmacokinetics*; D010920:Placenta / Q000737:chemistry / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D009020:Morphine
Transplatsentarnyĭ perenos i vliianie morfina, vvedennogo v prenatal'nom periode, na ego soderzhanie u vzroslykh krys.