Terminations of pregnancy for exposure to oral retinoids in South Australia, 1985-1993.
The oral retinoids, isotretinoin and etretinate, are highly teratogenic drugs which have been available in Australia since 1985 because of their unique effectiveness in severe cystic acne, psoriasis and other keratinization disorders. Only dermatologists can prescribe them, but in spite of strict guidelines by the manufacturers and the College of Dermatologists, exposed pregnancies have occurred. We attempted to determine the circumstances of exposure to these drugs for the 18 pregnancies terminated in South Australia in 1985-1993, using questionnaires to medical practitioners who notified the terminations under legislation. The main reason for their occurrence was the lack of compliance with the use of effective contraception by the women. In South Australia, some prescriptions of oral retinoids by unauthorized doctors have been dispensed during this period. Using statistics on prescriptions dispensed, an estimate was made of 1 termination of pregnancy for 319 courses of treatment for women with isotretinoin. Extension of guidelines for prescription and more detailed counselling in relation to the use of contraception are recommended. It is also suggested that doctors intending to recommend terminations obtain consent to discuss exposure with the dermatologists concerned, who may not be aware of the exposed pregnancy.
Chan
A
A
South Australian Health Commission, Adelaide, South Australia.
Keane
R J
RJ
Hanna
M
M
Abbott
M
M
D000028:Abortion, Induced / Q000706:statistics & numerical data; D000328:Adult; D003268:Contraception Behavior; D005260:Female; D006801:Humans; D011247:Pregnancy; D012176:Retinoids; D013021:South Australia; D013723:Teratogens
D012176:Retinoids; D013723:Teratogens