[Nisin, a potential preservative for topical preparations].
The lantibiotic compound nisin has a bacterial effect on gram positive bacteria and was investigated for the possible use as a preservative in topical formulations. For this reason, its minimal inhibitory concentration (MIC) was determined in different types of ointments. Beside its effect on gram positive bacteria it had also a bactericidal activity on gram negative bacteria in concentrations of 0.06% (W/W). Within the first month there was no detectable reduction of nisin activity in different dermatological preparations. We conclude from these results that the combination of nisin with fungicidal substances represents a possible alternative to well known preservatives.
Valenta
C
C
Institut für Pharmazeutische Technologie der Universität Wien, Austria.
Bernkop-Schnürch
A
A
Teltscher
C
C
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D004355:Drug Stability; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009561:Nisin / Q000737:chemistry / Q000494:pharmacology*; D011310:Preservatives, Pharmaceutical / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011310:Preservatives, Pharmaceutical; D009561:Nisin
Nisin, ein potentielles Konservierungsmittel in topischen Zubereitungen.