title: Similar fragmentation and dissolution after extracorporeal shock wave lithotripsy in eutrophic and overweight patients with gallstones.
abstract: The aim of this study was to assess the relative importance of overweight and adjuvant treatment with bile acids to obtain fragment dissolution and clearance after biliary extracorporeal shock wave lithotripsy (BESWL), in eutrophic and overweight patients with gallbladder stones. During a 3-year period 103 patients were treated with BESWL. Patients were strictly selected in terms of the number and type of stones. Of the total of 103 patients, 53 were women and 50 men. Mean age was 50.8 +/- 14.3 (range 17 to 86) years. Body mass index was calculated for each patient. All patients underwent BESWL with an electromagnetic device. Medical therapy for stone dissolution included the combination of chenodeoxycholic acid plus ursodeoxycholic acid (50% + 50%), at a total dose of 10-15 mg/day. Of the 103 patients, 45 were eutrophic and 58 were considered overweight. Age was similar in both groups. Number of lithotripsy sessions in eutrophic patients was 1.96 +/- 1.07 and 1.88 +/- 0.84 in overweight patients, but no statistical differences were found. Complete clearance of calculi was observed in more than 50% of the cases after 6 months, and reached 98% after 22 months of therapy in both groups. Total clearance of calculi was similar in patients with single and multiple stones. In conclusion, our results suggest that the time required to obtain complete gallstone clearance after BESWL is similar in eutrophic and overweight patients with gallbladder stones, and also that adjuvant therapy with bile acids plays an important role in gallstone fragment dissolution in these patients.
authors.affiliation: Department of Gastroenterology, National Institute of Nutrition, Tlalpan, Mexico City, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Uribe
authors.forename: N
authors.initials: N
authors.lastname: Méndez-Sánchez
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Vargas-Vorockova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002635:Chenodeoxycholic Acid; D002769:Cholelithiasis / Q000150:complications / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D016473:Gallbladder Emptying; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012307:Risk Factors; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid
chemical_list: D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid