Does sotalol have reverse-use dependence during tachyarrhythmias?
This study assessed the effect of intravenous sotalol on right ventricular effective refractory period at right ventricular pacing rates of 600 and 300 ms cycle length at 3, 6, 9, and approximately 30 minutes after the dose of sotalol. Similar percent increases occurred in the ventricular effective period at the 2 heart rates at all tested times (p >0.2 in each case), and it was concluded that there is no evidence for reverse-use dependence of intravenous sotalol in its effects on right ventricular refractoriness over this range of heart rates.
Kovoor
P
P
Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia.
Byth
K
K
Uther
J B
JB
Ross
D L
DL
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000494:pharmacology* / Q000627:therapeutic use; D013610:Tachycardia / Q000188:drug therapy*; D016278:Ventricular Function, Right / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D013015:Sotalol