Inflammatory pseudotumor of the pancreas.
We describe a rare example of inflammatory pseudotumor of the pancreas in a 42-yr-old woman, which developed following chemotherapy for lymphoma of the uterine cervix. The patient had developed fatigue, weight loss, abdominal pain, and anemia; abdominal CT scan showed a large mass in the pancreas. Examination of the resected specimen revealed a fleshy, well-circumscribed, 7-cm mass. Histologically, there was a hypocellular to moderately hypercellular, bland spindle-cell proliferation admixed with a prominent infiltrate of lymphocytes, histiocytes, and plasma cells. The spindle cells were vimentin positive but negative for muscle markers; electron microscopy revealed only fibroblastic cells. DNA analysis revealed a diploid population with low S-phase fraction. The patient was well at 6-mo follow-up. It is important for the pathologist to be aware of the existence of this entity in unusual locations such as the pancreas so as to avoid a mistaken diagnosis of malignancy.
Kroft
S H
SH
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
Stryker
S J
SJ
Winter
J N
JN
Ergun
G
G
Rao
M S
MS
D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D006104:Granuloma, Plasma Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D010182:Pancreatic Diseases / Q000378:metabolism / Q000473:pathology*
D004247:DNA