title: Radiation therapy for early glottic carcinoma (T1N0M0). The final results of prospective randomized study concerning radiation field.
abstract: OBJECTIVE
  To investigate the effect of radiation field on the local control of early glottic carcinoma by prospective randomized study.
  
  
  METHODS
  From May 1982 through February 1992, a total of 273 patients with early glottic carcinoma (T1N0M0) was treated at our department with a wedge filter technique using a shell to improve the dose distribution and immobilization during radiotherapy with 4 MV X-ray. Patients were randomly allocated to either treatment group A (radiation field size: 5 x 5 cm) or B (6 x 6 cm) using bilateral parallel opposed portals. Total radiation dose administered was 60 Gy in 30 fractions over a 6-week period.
  
  
  RESULTS
  The 5-year recurrence-free survival rates were 88% in groups A and B (no significant difference). Minor chronic complication such as persistent arytenoid edema lasting more than 6 months or benign polypoid lesion of vocal cord was more frequently observed in group B (23%) than in group A (17%) (p = 0.038) while acute mucosal reaction and skin reaction showed no significant differences.
  
  
  CONCLUSIONS
  A small field (5 x 5 cm) with an appropriate angle of wedge filter and shell fixing device is recommended to avoid adverse effect with keeping local control of early glottic carcinoma.
authors.affiliation: Department of Radiation Therapy, Center for Adult Diseases, Osaka.
authors.forename: M
authors.initials: M
authors.lastname: Chatani
authors.forename: Y
authors.initials: Y
authors.lastname: Matayoski
authors.forename: N
authors.initials: N
authors.lastname: Masaki
authors.forename: T
authors.initials: T
authors.lastname: Teshima
authors.forename: T o
authors.initials: To
authors.lastname: Inoue
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002423:Cause of Death; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D013997:Time Factors