[The role of adrenergic mechanisms in the anticonvulsive action of the new preparation acetylaminoazaleptin].
In mice experiments the effects of adrenergic drugs (anaprilin, pirroxan, fetanol and alupent) on anticonvulsive activity of acetylaminoazaleptin (AAA) using the test of maximal electroshock and AAA effect on phenamin-induced manifestation (stereotypy and hyperthermia) were studied. It was demonstrated that anaprilin significantly (6-fold) increased anticonvulsive activity of AAA. The other drugs did not change AAA activity. In the experiments with phenamin AAA slightly weaken stereotypy and significantly reduced hyperthermia manifestation.
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D018663:Adrenergic Agents / Q000494:pharmacology*; D018674:Adrenergic Antagonists / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D004347:Drug Interactions; D051379:Mice; D012007:Rectum; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D018663:Adrenergic Agents; D018674:Adrenergic Antagonists; D000927:Anticonvulsants
O roli adrenergicheskikh mekhanizmov v protivosudorozhnom deĭstvii novogo preparata atsetilaminoazaleptina.