[Study on pharmacokinetics of mitoxantrone polycyanoacrylate nanoparticles freeze-dried injection by HPLC column switching technique].
The drug concentration--time curves of mitoxantrone polycyanoacrylate nanoparticles freeze-dried injection (DHAQ-PBCA-NP-FDIn) and mitoxantrone solution injection (DHAQ-SIn) in rabbit blood were determined by HPLC column switching technique, and the difference between the DHAQ-PBCA-NP-FDIn and DHAQ-SIn in vivo was observed. The pharmacokinetic parameters of DHAQ-PBCA-NP-FDIn and DHAQ-SIn were presented by statistical moment. The results showed that the MRT and T1/2 of DHAQ-PBCA-NP-FDIn were 2.15 times longer than that of DHAQ-SIn, and the Vss was 4.81 times bigger than that of DHAQ-SIn. This indicates that DHAQ-PBCA-NP-FDIn has targeting and prolonging effect on the action in vivo.
Zhang
Z R
ZR
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Liao
G T
GT
Ye
L M
LM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004337:Drug Carriers; D004659:Enbucrilate; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008863:Microspheres; D008942:Mitoxantrone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008942:Mitoxantrone; D004659:Enbucrilate