[A study on the effective way and dosage of intravas deferens injection of HFMC for male contraception].
To investigate the effective way and dosage of intravas deferens injection of HFMC for male contraception, Teflon tubes of 1 mm caliber were used to imitate intravas injection of HFMC. We injected HFMC first, then the precipitant; thus HFMC could adhere to the walls and blend with the precipitant to precipitate. Eight adult male rabbits, exposed reproductive ducts were injected with dyed HFMC in opposite directions (upward and downward), HFMC flowed out of the distal end of the vas easily when its volume was more than that of the vas. 14 adult rabbits were used for the comparison of sperm density and fertility index between upward and downward injections of HFMC, and between the dosage of HFMC (50 microliters and 100 microliters) injected upward. The results show that it is difficult to attain contraception by intravas injection of HFMC downward, but contraception is quite possible by intravas injection of HFMC upward providing the volume is enough. The result also suggest that HFMC should be injected into vas deferens upward first; its volume should be 3 time as much as the natural volume of the vas from the injecting point to the epididymal end. Then a little precipitant is injected into the vas.
Yue
L
L
He
Y
Y
Zhang
J
J
Zeng
H
H
Luo
Z
Z
Xu
R
R
D000818:Animals; D003272:Contraceptive Agents, Male / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage*; D011109:Polymethacrylic Acids / Q000008:administration & dosage*; D011817:Rabbits; D014649:Vas Deferens
D003272:Contraceptive Agents, Male; D008689:Methacrylates; D011109:Polymethacrylic Acids; C063229:hydroxyethyl methacrylate-methacrylic acid-ethyl methacrylate copolymer