title: Satisfactory remission achieved by PUVA therapy in Langerhans cell hisiocytosis in an elderly patient.
abstract: Langerhans cell histiocytosis is currently regarded as a reactive proliferative process of Langerhans cells rather than a malignancy. The disease is characterized by Langerhans cell infiltration of skin, lung, bone and other organs. We report a 74-year-old man with Langerhans cell histiocytosis who had generalized hemorrhagic and crusted papules. He also had diabetes insipidus. Because he did not have any severe constitutional symptoms or failure of vital organs, we applied topical PUVA treatment to his skin lesions, which responded well to the therapy. Diabetes insipidus, however, remained, in spite of X ray radiotherapy for the pituitary lesion.
authors.affiliation: Department of Dermatology, Asahikawa Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Ibe
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: I
authors.initials: I
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Oomori
authors.forename: H
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D000368:Aged; D003919:Diabetes Insipidus / Q000150:complications / Q000532:radiotherapy; D004817:Epidermis / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D011701:PUVA Therapy; D012074:Remission Induction; D017444:Skin Diseases, Papulosquamous / Q000150:complications / Q000188:drug therapy* / Q000473:pathology