title: [The modification of a radiation lesion with 9a-homo-13-thiaprostanoids].
abstract: The radioprotective properties of 12 compounds of 9a-homo-13-thiaprostanoid series were investigated under gamma irradiation using the molecular model of beta-carotene radio-oxidation in oleic acid in vitro, erythrocyte radiomimetic model in ex vivo-in vitro system as well as in vivo radiation damage in mice. Most of these compounds stimulated the radio-oxidation of beta-carotene, however in this model two prostanoids with natural alpha-chain displayed radioprotective properties. Expressed membrane stabilizing effect of two 9a-homo-13-thiaprostanoid nor-analogues was revealed in radiomimetic model experiments. Two 10, 10-dimethyl-13-thiaprostanoids raised animal radioresistance during in vivo experiments.
authors.forename: B B
authors.initials: BB
authors.lastname: Kuz'mitskiĭ
authors.forename: I G
authors.initials: IG
authors.lastname: Dad'kov
authors.forename: M B
authors.initials: MB
authors.lastname: Golubeva
authors.forename: V M
authors.initials: VM
authors.lastname: Nasek
authors.forename: T S
authors.initials: TS
authors.lastname: Khlebnikova
authors.forename: I I
authors.initials: II
authors.lastname: Petrusevich
authors.forename: F A
authors.initials: FA
authors.lastname: Lakhvich
mesh_terms: D000818:Animals; D002338:Carotenoids / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000528:radiation effects; D005260:Female; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D013329:Structure-Activity Relationship; D019207:beta Carotene
chemical_list: D011453:Prostaglandins; D011837:Radiation-Protective Agents; D019207:beta Carotene; D002338:Carotenoids
vernacular_title: Modifikatsiia luchevogo porazheniia 9a-gomo-13-tiaprostanoidami.