Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy.
Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU family transcription factor Oct-2 is known to be induced in sensory neurons by nerve growth factor (NGF) and might therefore be affected by the removal of target-derived NGF following axotomy. Paradoxically, however, the expression of Oct-2 showed a transient increase of two- to three-fold 24 h after axotomy. In contrast, axotomy had no effect on the levels of the Brn-3 sub-family of POU proteins, indicating that this effect was specific for Oct-2.
Begbie
J L
JL
Department of Molecular Pathology, University College London Medical School, UK.
Wood
J N
JN
Anderson
P N
PN
Latchman
D S
DS
D000818:Animals; D001369:Axons / Q000502:physiology*; D004268:DNA-Binding Proteins; D017403:In Situ Hybridization; D050813:Octamer Transcription Factor-2; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000378:metabolism*; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism*; D015854:Up-Regulation
D004268:DNA-Binding Proteins; D050813:Octamer Transcription Factor-2; C489205:Pou2f2 protein, rat; D014157:Transcription Factors