Oligoblastic leukaemia with (8;21) translocation and haemophagocytic syndrome and granulocytic cannibalism.
We report a 47-year-old man with oligoblastic leukaemia (8;21) translocation, phenomenon of cannibalism by granulocytic cells and haemophagocytic syndrome. The patient responded to intensive chemotherapy with disappearance of haemophagocytosis, granulocytic and histiocytic. We conclude that: (1) granulocytic cannibalism and haemophagocytic syndrome can be unusual myelodysplastic features; (2) the oligoblastic leukaemia with presence of cytogenetic abnormalities related to AML in young patients are probably more close to acute leukaemia than to myelodysplastic syndrome.
Domingo-Claros
A
A
Servicio de Hematologia-Citologia, Hospital de Bellvitge, Universidad de Barcelona, Spain.
Alonso
E
E
Aventin
A
A
Petit
J
J
Crespo
N
N
Ponce
C
C
Grañena
A
A
D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006098:Granulocytes / Q000473:pathology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic