title: Induction of SPI-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia.
abstract: We cloned genes the expression of which is induced in the Mongolian gerbil (Meriones unguiculatus) hippocampus after transient forebrain ischemia by a differential display technique. Among these genes, a rat serine protease inhibitor SPI-3 homologue was isolated. Present analyses suggested that the expression of gerbil SPI-3 mRNA was closely associated with delayed neuronal death and may block activities of proteases leaking from degenerating neurons or may support neuronal survival.
authors.affiliation: Department of Molecular Neurobiology Tanabe, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsuda
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
authors.forename: K
authors.initials: K
authors.lastname: Imaizumi
authors.forename: A
authors.initials: A
authors.lastname: Wanaka
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
authors.forename: T
authors.initials: T
authors.lastname: Takagi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017386:Sequence Homology, Amino Acid; D015842:Serine Proteinase Inhibitors / Q000096:biosynthesis*; D013997:Time Factors; D014158:Transcription, Genetic
chemical_list: D015347:RNA Probes; D012333:RNA, Messenger; D015842:Serine Proteinase Inhibitors