[Chemiluminescence, blood lipid peroxidation and neutrophil activity during the hypoxic training of persons subjected to ionizing radiation exposure].
Free radical processes and some indices of antibacterial defense system have been examined in 29 male residents of Chernobyl area during adaptation to periods of intermittent hypoxia. 18 men (the experimental group) were exposed to normobaric isocapnic progressive hypoxia during 10 days of three daily 5-7 min sessions with 15 min breaks, and 11 men (control group) were exposed to air breathing. All subjects were divided into two subgroups with initial high (1) and low (2) level of blood chemiluminescence (ChL). Patients of the 1 subgroup were characterized with high oxygen-generated activity of neutrophils (OGA) and high malondialdehyde (MDA) concentration. After hypoxic training (HT) there was a decrease of spontaneous and initiated ChL and MDA. Patients of the 2 subgroup were characterised with low level both spontaneous and initiated ChL, low MDA concentration and low phagocytosing activity of neutrophils. After HT there was significant rise of initiated ChL and MDA concentration up to normal level with the increasing of neutrophil phagocytosing activity. We suggest that HT causes the normalizing effect on free radical processes in subjects who were exposed to radiation influences.
Serebrovskaia
Z A
ZA
Serebrovskaia
T V
TV
Afonina
G B
GB
D000328:Adult; D000704:Analysis of Variance; D005609:Free Radicals / Q000097:blood / Q000528:radiation effects; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008055:Lipids / Q000097:blood / Q000528:radiation effects*; D008163:Luminescent Measurements; D008297:Male; D018375:Neutrophil Activation / Q000528:radiation effects*; D009504:Neutrophils / Q000378:metabolism / Q000528:radiation effects*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D010587:Phagocytosis / Q000528:radiation effects; D011210:Power Plants; D018788:Radioactive Hazard Release; D014455:Ukraine
D005609:Free Radicals; D008055:Lipids
Khemiliuminestsentsiia, perekisnoe okislenie lipidov krovi i aktivnost' neĭtrofilov pri gipoksicheskoĭ trenirovke u lits, podvergshikhsia vozdeĭstviiu ioniziruiushchego izlucheniia.