title: Differentiation of subsets of CD4+ and CD8+ T cells.
abstract: Our knowledge of the cytokine secretion patterns of T cells and other cells is clearly becoming more complex. The T helper 1 (Th1) and Th2 patterns may represent the extremes of a spectrum of cytokine regulatory patterns controlled by several cell types. CD8+ T cells can also secrete either Th1-like or Th2-like cytokine patterns, and they can contribute to bystander B cell activation. Interactions occur between immune cytokine regulatory networks and other systems, and pregnancy and responses against infection can profoundly influence each other.
authors.affiliation: Department of Immunology, University of Alberta, Edmonton, Canada.
authors.forename: T R
authors.initials: TR
authors.lastname: Mosmann
authors.forename: S
authors.initials: S
authors.lastname: Sad
authors.forename: L
authors.initials: L
authors.lastname: Krishnan
authors.forename: T G
authors.initials: TG
authors.lastname: Wegmann
authors.forename: L J
authors.initials: LJ
authors.lastname: Guilbert
authors.forename: M
authors.initials: M
authors.lastname: Belosevic
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology
chemical_list: D016207:Cytokines