Axonal channelopathies: an evolving concept in the pathogenesis of peripheral nerve disorders.
Abnormalities of peripheral nerve Na+ and K+ channels result in clinical manifestations unrelated to axonal degeneration or demyelination. Na+ channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K+ channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating disorders.
Gutmann
L
L
Department of Neurology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown 26506-9180, USA.
Gutmann
L
L
D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D015221:Potassium Channels / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology*
D015221:Potassium Channels; D015222:Sodium Channels