title: [A new synthesis of 1,4-dihydropyridines: cyclocondensation of aldimines].
abstract: The reaction of 2-nitro-benzaldehyde with ammonia gives different products (1a-c) depending on the reaction conditions. All of them were suitable to prepare nifedipine, the well known Ca-antagonist compound. This new synthesis route is independent of the hitherto well-known methods. Moreover, the purity and stability of the received material prevails over the other marketed products. The reaction of 1a was studied with methyl acetoacetate and 3-aminocrotonate.
authors.forename: D
authors.initials: D
authors.lastname: Bózsing
authors.forename: L G
authors.initials: LG
authors.lastname: Koványiné
mesh_terms: D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D007097:Imines; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D004095:Dihydropyridines; D007097:Imines; D007202:Indicators and Reagents; C038806:1,4-dihydropyridine
vernacular_title: Egy új 1,4-dihidropiridin szintézis Aldiminek ciklokondenzációs reakciója.