title: Morphine-augmented hepatobiliary scintigraphy: a meta-analysis.
abstract: The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HBS often include non-candidates for MA-HBS. However, using meta-analytic techniques to combine data from eligible studies (4 for C-HBS and 5 for MA-HBS), the specificity of MA-HBS (0.84; 95% CI = 0.75-0.94) was significantly greater (P = 0.008) than that of C-HBS (0.68; 95% CI = 0.61-0.75); there were no differences in sensitivity (MA-HBS; 0.96, 95% CI = 0.92-0.99; C-HBS: 0.97, 95% CI = 0.97-0.99).
authors.affiliation: Johns Hopkins University Hospital, Baltimore, MD, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Cabana
authors.forename: A
authors.initials: A
authors.lastname: Alavi
authors.forename: J A
authors.initials: JA
authors.lastname: Berlin
authors.forename: J A
authors.initials: JA
authors.lastname: Shea
authors.forename: C K
authors.initials: CK
authors.lastname: Kim
authors.forename: S V
authors.initials: SV
authors.lastname: Williams
mesh_terms: D000208:Acute Disease; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D002764:Cholecystitis / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D015201:Meta-Analysis as Topic; D009020:Morphine; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
chemical_list: D009020:Morphine