The effect of ACE inhibitors on the expression of matrix genes and the role of p53 and p21 (WAF1) in experimental renal fibrosis.
Tubulointerstitial fibrosis in unilateral ureteral obstruction (UUO) is driven by increased levels of angiotensin II (AII). In this study we administered the angiotensin converting enzyme (ACE) inhibitor enalapril to rats with UUO after tubulointerstitial fibrosis was established. Treatment with the ACE inhibitor halted the progression of fibrosis and to a significant extent reversed some aspects of tubulointerstitial fibrosis. It is suggested that enalapril administration may be an effective means of preventing the progression of tubulointerstitial fibrosis.
Morrissey
J J
JJ
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. morrisse@imgate.wustl.edu
Ishidoya
S
S
McCracken
R
R
Klahr
S
S
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression / Q000187:drug effects*; D016158:Genes, p53 / Q000187:drug effects*; D006023:Glycoproteins / Q000096:biosynthesis; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009395:Nephritis, Interstitial / Q000473:pathology; D015689:Oncogene Protein p21(ras) / Q000096:biosynthesis* / Q000235:genetics; D012313:RNA / Q000096:biosynthesis / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D019714:Tissue Inhibitor of Metalloproteinases; D016212:Transforming Growth Factor beta / Q000096:biosynthesis
D000806:Angiotensin-Converting Enzyme Inhibitors; D006023:Glycoproteins; D019714:Tissue Inhibitor of Metalloproteinases; D016212:Transforming Growth Factor beta; D012313:RNA; D003094:Collagen; D015689:Oncogene Protein p21(ras)