Cardiac toxicity with cisapride.
Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and Q-T prolongation have been reported in patients taking cisapride with other drugs that inhibit the cytochrome P450-3A4 hepatic enzyme. This column will review the mechanism of action of cisapride, the drug's metabolism and reported cardiac adverse effects with intravenous cisapride.
Farrington
E
E
D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002648:Child; D020117:Cisapride; D004357:Drug Synergism; D006801:Humans; D010880:Piperidines / Q000009:adverse effects* / Q000378:metabolism; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000378:metabolism
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride