Transgenic mice: models for the study of cataractogenesis. A minireview.
Genetic manipulation followed by (over)expression of the transgene product in lens tissue results in: (I) inhibition of denucleation of lens fibers; (II) interference with lens cell differentiation; (III) cataract formation. The events reviewed are preceded by membrane damage, perturbed assembly of the IF cytoskeleton and distortion of the cytoskeleton-membrane complex.
Bloemendal
H
H
Department of Biochemistry, University of Nijmegen, The Netherlands.
Benedetti
E L
EL
Dunia
I
I
D000818:Animals; D002386:Cataract / Q000209:etiology*; D003459:Crystallins / Q000235:genetics; D005796:Genes; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic
D003459:Crystallins