title: Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus.
abstract: The neural basis underlying the cognitive side effects of ECT is unknown. Recent studies suggest that the memory dysfunction may be caused by alterations in hippocampal synaptic efficacy [20]. In situ hybridisation was used to examine the possible receptor mechanisms responsible for this effect. Repeated ECS markedly increased mRNA expression for the GluR1 subunit of the AMPA receptor, but not the NMDAR1A-G subtypes of the NMDA receptor, relative to control treatments. This effect was present 24 h after the last seizure and may be responsible for the expression of the ECS-induced increase in synaptic efficacy.
authors.affiliation: Department of Psychiatry, University of Sheffield, UK.
authors.forename: P
authors.initials: P
authors.lastname: Naylor
authors.forename: C A
authors.initials: CA
authors.lastname: Stewart
authors.forename: S R
authors.initials: SR
authors.lastname: Wright
authors.forename: R C
authors.initials: RC
authors.lastname: Pearson
authors.forename: I C
authors.initials: IC
authors.lastname: Reid
mesh_terms: D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D004597:Electroshock; D006624:Hippocampus / Q000378:metabolism*; D017403:In Situ Hybridization; D017774:Long-Term Potentiation; D008297:Male; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D018091:Receptors, AMPA / Q000096:biosynthesis*; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis*; D013462:Sulfur Radioisotopes; D014158:Transcription, Genetic
chemical_list: D009419:Nerve Tissue Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D013462:Sulfur Radioisotopes