Putative linkage between HLA class I polymorphism and the susceptibility to malignant melanoma.
Human leukocyte antigen (HLA) frequencies in 67 melanoma patients were compared to 120 controls in Japan. The frequency of HLA-B13 was increased in melanoma patients compared to controls and was particularly common in nodular melanoma HLA-B61 was decreased in melanoma patients. Almost 50% of acral lentiginous melanoma patients expressed HLA-B51 compared to 0% of nodular melanomas.
Ichimiya
M
M
Department of Dermatology, Yamaguchi University School of Medicine, Japan.
Muto
M
M
Hamamoto
Y
Y
Ohmura
A
A
Tateno
H
H
Asagami
C
C
D044466:Asian People / Q000235:genetics*; D004198:Disease Susceptibility / Q000208:ethnology; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007564:Japan; D008545:Melanoma / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012016:Reference Values; D012878:Skin Neoplasms / Q000208:ethnology / Q000235:genetics*
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens