Positive selection of CD4+ and CD8+ T cells.
Significant progress has been made in characterizing intermediates and defining individual steps of positive selection, providing important insights into mechanisms of CD4/CD8 lineage commitment. New evidence suggests that specific recognition of peptides may be important for positive selection of CD4+ T cells. Several studies have defined signal-transduction pathways important for positive selection and have provided evidence that distinct signaling pathways may regulate positive versus negative selection.
Guidos
C J
CJ
Division of Immunology & Cancer, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada. guidos@sickkids.on.ca
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000502:physiology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D015398:Signal Transduction / Q000276:immunology