The precipitate formed by thiopentone and vecuronium.
OBJECTIVE
To determine the composition and solubility of the precipitate formed by thiopentone and vecuronium in vitro.


METHODS
The precipitate formed by mixing thiopentone 2.5% and vecuronium 0.1% at room temperature was analyzed by ultraviolet spectrophotometry and high performance liquid chromatography (HPLC). The solubility of the precipitate in human plasma was measured by HPLC.


RESULTS
The UV absorption spectrum of the precipitate resembled that of thiopentone. HPLC analysis produced a single peak with the same retention time as thiopentone (4.6 min). In human plasma the solubility of the precipitate was not different from that of thiopentone acid. The solubility of thiopentone was greater than that of the precipitate.


CONCLUSIONS
The precipitate formed by thiopentone and vecuronium in vitro consisted of thiopentone acid, which was insoluble in human plasma.
Taniguchi
T
T
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Japan.
Yamamoto
K
K
Kobayashi
T
T
D011232:Chemical Precipitation; D006801:Humans; D006993:Hypnotics and Sedatives / Q000737:chemistry*; D003473:Neuromuscular Nondepolarizing Agents / Q000737:chemistry*; D012995:Solubility; D013874:Thiopental / Q000737:chemistry*; D014673:Vecuronium Bromide / Q000737:chemistry
D006993:Hypnotics and Sedatives; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D013874:Thiopental