title: Effects of in vivo cocaine administration on human platelet aggregation.
abstract: To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Heesch
authors.forename: B H
authors.initials: BH
authors.lastname: Negus
authors.forename: M
authors.initials: M
authors.lastname: Steiner
authors.forename: I I
authors.initials: II
authors.lastname: Snyder RW
authors.forename: D D
authors.initials: DD
authors.lastname: McIntire
authors.forename: P A
authors.initials: PA
authors.lastname: Grayburn
authors.forename: J
authors.initials: J
authors.lastname: Ashcraft
authors.forename: J A
authors.initials: JA
authors.lastname: Hernández
authors.forename: E J
authors.initials: EJ
authors.lastname: Eichhorn
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003042:Cocaine / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009391:Nephelometry and Turbidimetry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011446:Prospective Studies
chemical_list: D010975:Platelet Aggregation Inhibitors; D003042:Cocaine