Antimicrobial steroids from the fungus Fomitopsis pinicola.
Phytochemical examination of the dichloromethane extract of the European fungus Fomitopsis pinicola led to the isolation of a new lanostanoid derivative identified from spectral and chemical evidences as 3 alpha-(4-carboxymethyl-3-hydroxy-3-methylbutanoyloxy)-lanosta++ +-8,24-dien-21-oic acid. In addition, seven known triterpenes, polyporenic acid C, 3 alpha-acetyloxylanosta-8,24-dien-21-oic acid, ergosta-7,22-dien-3 beta-ol,21-hydroxylanosta-8,24-dien-3-one, pinicolic acid A, trametenolic acid B and pachymic acid, were also isolated. Antimicrobial activity against Bacillus subtilis in a TLC bioassay was observed for five of the isolated steroids.
Keller
A C
AC
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Lausanne-Dorigny, Switzerland.
Maillard
M P
MP
Hostettmann
K
K
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000890:Anti-Infective Agents; D013256:Steroids