[The quantitative morphology of the cells in the basal layer of the multilayer epithelium in the mouse cornea and in a human cancerous lung tumor].
The following categories of cells are present in the epithelium basal layer: "elongated", "transitional", "narrow", "circular", and "oval", corresponding to peaks 1, 2, A, B, and C. Peak 1 cells with the ellipticity 0.5774 have the highest specific weight. Upon maturation, these cells become "transitional" cells and mitotic, or "elongated", cells. During proliferation, some "elongated" cells mature to become more differentiated "narrow" cells. The "elongated" cells are characterized by synchronization. When 30% of the cells in the population become "elongated", 5% of them enter mitosis. Transition of 5% of the "elongated" cells to mitosis occurs only when the number of peak B cells becomes equal to that of peak A cells. When the "elongated" cells amount to 30% of the population, transition of peak B cells into peak A cells ceases. In the tumor tissue of the human lung, there are the same series and peaks of cell distribution as in the normal epithelium. There is the same functional relationship between the "elongated" cells and peak B and peak A cells as in the normal epithelium, when transition of 4-5% of "elongated" cells to mitosis is possible only upon leveling of peaks B and A. When the relative number of "elongated" cells reaches 30%, transition of peak B cells into peak A cells also ceases.
Iavisheva
T M
TM
Iagubov
A S
AS
D000328:Adult; D000818:Animals; D001485:Basement Membrane / Q000166:cytology; D002455:Cell Division; D004728:Endothelium, Corneal / Q000166:cytology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D008938:Mitosis; D012016:Reference Values
Kolichestvennaia morfologiia kletok bazal'nogo sloia mnogosloĭnogo épiteliia rogovitsy myshi i rakovoĭ opukholi legkogo cheloveka.