[The effect of armin on neuromuscular transmission in the frog against a background of hexadecamethonium action].
Hexadecamethonium as well as its alkylating derivatives significantly decrease the effect of organophosphorous acetylcholinesterase inhibitor armine on the amplitude and duration of the EPPs. It seems possible that these substances prevent inhibition of acetylcholinesterase. This property of the substances seems to be due to a polymethelene chain with two nitrogens as the basic part of the molecule structure.
Grigor'ev
V M
VM
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001138:Armin / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003650:Decamethonium Compounds / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D008839:Microelectrodes; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011896:Rana temporaria; D012426:Russia; D013329:Structure-Activity Relationship; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D000477:Alkylating Agents; D002800:Cholinesterase Inhibitors; D003650:Decamethonium Compounds; C098878:hexadecamethonium; D001138:Armin
Vliianie armina na nervno-myshechnuiu peredachu liagushki na fone deĭstviia geksadekametoniia.