Developmental expression of the mouse MHC Q genes.
To investigate the role of class Ib genes in the Q region of the mouse major histocompatibility complex (MHC), the developmental expression and foetal tissue distribution of the Q genes were studied in the C57BL/6 mouse. Using RNase protection assays, we examined Q gene expression in a wide spectrum of foetal tissues at different stages of gestation, Q4, Q6 and Q8 were widely expressed in a variety of tissues. In contrast, the expression of Q1 was restricted to the thymus and intestinal epithelium.
Wang
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Q
Department of Biomedical Sciences, School of Public Health, University at Albany, NY 12201, USA.
Flaherty
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L
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D005805:Genes, MHC Class I; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data
D017931:DNA Primers