title: [Evaluation of reserved hepatic function in patients with hepatobiliary tumor by 99mTc-GSA: effect of hyperbilirubinemia and usefulness of regional reserved hepatic functional imaging].
abstract: The evaluation of the reserved hepatic function was performed by 99mTc-galactosyl serum albumin (99mTc-GSA) in seventy patients with hepatobiliary tumor. The dynamic study was performed to evaluate global reserved hepatic function following the intravenous bolus injection of 99mTc-GSA, and the hepatic single photon emission computed tomography (SPECT) was obtained to assess the regional reserved hepatic function. The functional hepatic index (LHL15) was derived from liver time-activity data, and it was compared with serum total-bilirubin level, serum albumin level and plasma disappearance rate of indocyanine green (ICG15). In the patients with hepatocellular carcinoma, LHL15 value agreed well with ICG15 value, serum total-bilirubin level, and serum albumin level. Moderate or severe hepatic dysfunction was observed at 65.4% of these patients. In the patients with cholangiocellular carcinoma, a discrepancy of LHL15 value and ICG15 value was observed. Increment of the ICG15 value was correlated with that of the serum total-bilirubin level, whereas the correlations was not observed between the LHL15 value and the serum total-bilirubin level. These results indicate that 99mTc-GSA scintigraphy can evaluate the reserved hepatic function without the embellishment of jaundice. This method is useful for assessing the global and regional reserved hepatic function.
authors.affiliation: Institute of Clinical Medicine, University of Tsukuba, Ibaragi, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: N
authors.initials: N
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Fukunaga
authors.forename: T
authors.initials: T
authors.lastname: Todoroki
authors.forename: T
authors.initials: T
authors.lastname: Okumura
authors.forename: R
authors.initials: R
authors.lastname: Hatakeyama
authors.forename: Y
authors.initials: Y
authors.lastname: Itai
mesh_terms: D000368:Aged; D001661:Biliary Tract Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000503:physiopathology*; D007208:Indocyanine Green; D008099:Liver / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; D007208:Indocyanine Green; D016284:Technetium Tc 99m Pentetate