title: Differentiation and tolerance of CD4+ T lymphocytes.
abstract: The development of effector and memory populations of T lymphocytes is determined by antigen-induced growth and differentiation of naive T cells, and it is regulated by antigen-induced functional tolerance and cell death. CD4+ helper T lymphocytes that vary in their profiles of cytokine production and in effector functions also show distinct responses to antigens and co-stimulatory signals, and they differ in their sensitivity to tolerance induction. Thus, stimuli that trigger T cell growth and differentiation, as well as mechanisms that inhibit T cell expansion, determine both the magnitude and the nature of T cell-dependent immune responses to protein antigens.
authors.affiliation: Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Abbas
authors.forename: V L
authors.initials: VL
authors.lastname: Perez
authors.forename: L
authors.initials: L
authors.lastname: Van Parijs
authors.forename: R C
authors.initials: RC
authors.lastname: Wong
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D006801:Humans; D007108:Immune Tolerance