title: Viscoelasticity of hyaluronic acid with different molecular weights.
abstract: Storage and loss moduli of hyaluronic acid solutions with different molecular weights were observed as a function of frequency in the presence of sugars and salts. The hyaluronic acid solutions of higher molecular weight (Mw > 17 x 10(6)) fractions showed entanglement, whereas lower molecular weight fractions did not. For inducing the entanglement of molecular chains of hyaluronic acid, increasing the molecular weight of hyaluronic acid was more effective than increasing the concentration of the lower molecular weight fractions (Mw = 7. 8 x 10(5). Glucose, fructose, galactose, and sucrose increased both storage and loss moduli, while NaCl, KCl and CaCl2 decreased both moduli. It is suggested that sugars create hydrogen bonds and strengthen the transient network. Cations shield the electrostatic repulsion of hyaluronic acid molecules, and the polymer chains are shrunk into compact coils from expanded stiffened coils.
authors.affiliation: Research Center, Denki Kagaku Kogyo Co., Ltd, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Nishinari
mesh_terms: D002241:Carbohydrates; D004548:Elasticity; D004563:Electrochemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D006860:Hydrogen Bonding; D066298:In Vitro Techniques; D008970:Molecular Weight; D012212:Rheology; D012492:Salts; D012996:Solutions; D014783:Viscosity
chemical_list: D002241:Carbohydrates; D012492:Salts; D012996:Solutions; D006820:Hyaluronic Acid