title: [Ulcerated necrobiosis lipoidica associated with insulin-dependent diabetes mellitus. Beneficial effect of corticosteroid therapy by oral administration].
abstract: OBJECTIVE
  Necrobiosis lipoidica is a rare degenerative disease of dermal connective tissue usually observed in young diabetic patients. Several drugs have been suggested to be useful, but none have been shown to be effective in all cases.
  
  
  METHODS
  A young patient with insulin-dependent diabetes had a severe invalidating ulcerated necrobiosis lipoidica. Oral corticosteroids led to a satisfactory regression then stabilization with 6 mg/d prednisone.
  
  
  CONCLUSIONS
  Oral corticosteroids would appear to be effective treatment and should be validated by controlled studies. Corticosteroids should only be used in exceptionally severe forms of ulcerated necrobiosis lipoidica after failure of conventional treatments. Diabetes would be an indication under strict metabolic control.
authors.affiliation: Service d'Endocrinologie, Hôpital Saint-Louis, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Hocqueloux
authors.forename: J F
authors.initials: JF
authors.lastname: Gautier
authors.forename: C
authors.initials: C
authors.lastname: Lebbe
authors.forename: M
authors.initials: M
authors.lastname: Jellal
authors.forename: P
authors.initials: P
authors.lastname: Vexiau
authors.forename: P
authors.initials: P
authors.lastname: Morel
authors.forename: G
authors.initials: G
authors.lastname: Cathelineau
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009335:Necrobiosis Lipoidica / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology*
chemical_list: D005938:Glucocorticoids; D011241:Prednisone
vernacular_title: Nécrobiose lipoïdique ulcérée associée au diabète insulinodépendant. Effet bénéfique de la corticothérapie par voie orale.