Local distribution of mepivacaine after distal interphalangeal joint injection in horses.
OBJECTIVE
To evaluate the distribution of mepivacaine hydrochloride after distal interphalangeal (DIP) joint injection in horses.


METHODS
Prospective, uncontrolled study.


METHODS
10 adult horses.


METHODS
30 minutes before euthanasia, 8 ml of 2% mepivacaine hydrochloride was injected into the dorsal pouch of a forelimb DIP joint. Synovial tissue from the DIP joint and podotrochlear (navicular) bursa and bone tissue from the medullary cavity of the distal sesamoid (navicular) bone were taken from both forelimbs immediately after death. All synovial and bone specimens were analyzed for tissue concentration of mepivacaine by high-performance liquid chromatography. Synovial tissue and bone specimen concentrations from the injected forelimb were compared with corresponding specimens from the noninjected forelimb. All synovial tissue and bone specimen concentrations were compared with an estimated effective tissue concentration of mepivacaine (0.3 microgram/mg) for local anesthesia.


RESULTS
Specimen concentrations of mepivacaine from the injected forelimb were significantly greater (P < 0.05) than those in the corresponding tissues of the contralateral noninjected forelimb. All DIP joint and navicular bursa synovial tissue specimens from the injected forelimb had greater than the estimated effective tissue concentration of mepivacaine for local anesthesia. Of the 10 navicular bone specimens from the injected forelimb, 4 were higher and 2 were within 20% of the estimated effective tissue concentration of mepivacaine for local anesthesia.


CONCLUSIONS
Mepivacaine hydrochloride deposited into the DIP joint should anesthetize pain arising from navicular bursa synovia and may decrease pain arising from the medullary cavity of the navicular bone.


CONCLUSIONS
DIP joint injection of mepivacaine hydrochloride is not specific for DIP joint pain.
Keegan
K G
KG
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Wilson
D A
DA
Kreeger
J M
JM
Ellersieck
M R
MR
Kuo
K C
KC
Li
Z
Z
D000818:Animals; D005260:Female; D005552:Forelimb; D006734:Horse Diseases; D006736:Horses; D007267:Injections; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009069:Movement Disorders / Q000503:physiopathology / Q000662:veterinary; D011446:Prospective Studies; D014033:Toe Joint / Q000378:metabolism*
D008619:Mepivacaine