title: [Immunologic characteristics of undernutrition. I. The undernourished patient in nutritional recovery].
abstract: Malnutrition in children is a well known critical factor that determines immunocompetence changes with altered immune response and higher risk to many diseases, especially in developing countries. Moreover, it is related to increased morbi-mortality rates mainly due to infections. For those reasons, 12 undernourished children, age 5 to 24 months were studied along 8 weeks at the Nutritional Recovery Center of Chiquinquira Hospital in Maracaibo, Venezuela. There were 5 cases of kwashiorkor, 5 marasmatics, 1 mixed marasmus/kwashiorkor and 1 case with moderate malnutrition. After a control blood sample was taken and cutaneous tests were done, a nutritional recovery program was began. At regular time intervals and at the end of the study, tests were done again by measuring seric immunoglobulins (IgG, IgA, IgM), secretory IgA (IgAs), C3 and C4 complement, lymphocytic sub-populations, and auto antibodies; cutaneous hipersensitivity tests were also done. As a control group, 10 apparently healthy children of matching age and sex were also studied with the same parameters. Results show that basal seric Igs did not differ significantly from the control group and did not change along the recovery program period, but there was a significant decrease in IgAs at all times of the study. C4 did not change and C3 was lower than control (p < 0.05) but returned to normal value at the end of the recovery period. CD3 and CD4 lymphocytes showed the same pattern. Only two patients showed positive skin tests and auto antibodies were not detected. It is concluded that there is indeed an altered immune competence with low levels of C3, IgAs, and CD3-CD4 lymphocytes that is reversible after nutritional recovery.
authors.affiliation: Cátedra de Microbiología, Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
authors.forename: A
authors.initials: A
authors.lastname: Amesty-Valbuena
authors.forename: M
authors.initials: M
authors.lastname: Diez-Ewald
authors.forename: M
authors.initials: M
authors.lastname: de Villarroel
authors.forename: N
authors.initials: N
authors.lastname: Montiel
authors.forename: A
authors.initials: A
authors.lastname: Granados
authors.forename: S
authors.initials: S
authors.lastname: Díaz
authors.forename: D
authors.initials: D
authors.lastname: Salas
authors.forename: M
authors.initials: M
authors.lastname: Rivero
mesh_terms: D015703:Antigens, CD / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007223:Infant; D008137:Longitudinal Studies; D009748:Nutrition Disorders / Q000097:blood / Q000276:immunology* / Q000628:therapy
chemical_list: D015703:Antigens, CD; D007136:Immunoglobulins
vernacular_title: Aspectos inmunológicos del desnutrido. I. El desnutrido en recuperación nutricional.