title: Tropisetron and metoclopramide in the prevention of postoperative nausea and vomiting. A comparative, placebo controlled study in patients undergoing ophthalmic surgery.
abstract: One hundred and twenty patients undergoing elective ophthalmic surgery under general anaesthesia were investigated in a randomised, double-blind, parallel group study of postoperative nausea and vomiting. Patients received tropisetron 0.1 mg.kg-1, metoclopramide 0.25 mg.kg-1 or placebo given at the end of anaesthesia. In comparison with placebo, tropisetron significantly reduced the degree of nausea (p < 0.01), whereas metoclopramide reduced both nausea (p < 0.05) and vomiting (p < 0.05). There were no statistically significant differences between the two active agents in their efficacy to postoperative nausea and vomiting. The patients in the placebo group required rescue antiemesis more often in the postanaesthesia care unit. Our results suggest that tropisetron may not be suitable as a routine, primary therapy for the prevention of postoperative nausea and vomiting.
authors.affiliation: Department of Anaesthesiology, University Hospital of Turku, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Ali-Melkkilä
authors.forename: J
authors.initials: J
authors.lastname: Kanto
authors.forename: R
authors.initials: R
authors.lastname: Katevuo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000932:Antiemetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications / Q000517:prevention & control*; D000077526:Tropisetron; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D007211:Indoles; D000077526:Tropisetron; D008787:Metoclopramide