title: A case of acrogeria associated with late-onset focal dermal elastosis.
abstract: We report a case of acrogeria. Biochemical analysis of patient fibroblasts demonstrated unaltered type III collagen synthesis. An RNA hybridization assay demonstrated that the levels of type I and elastin mRNAs were normal. The patient had multiple yellow papules on the neck, axilla and inguinal area which clinically and histologically resembled late-onset focal dermal elastosis. Both diseases may have some similar abnormal metabolism of connective tissue.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tajima
authors.forename: T
authors.initials: T
authors.lastname: Inazumi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001284:Atrophy; D001706:Biopsy; D003094:Collagen / Q000378:metabolism; D004547:Elastic Tissue / Q000473:pathology*; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005528:Foot; D006025:Glycosaminoglycans / Q000652:urine; D006225:Hand; D006801:Humans; D012313:RNA / Q000032:analysis; D012867:Skin / Q000473:pathology*; D015595:Skin Aging / Q000473:pathology*; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D006025:Glycosaminoglycans; D012313:RNA; D003094:Collagen