title: Tracking antigen-specific helper T cell responses.
abstract: T-cell receptor transgenic animals provide an excellent source of T cells for the analysis of antigen-specific helper T-cell development. Alternatively, studies in normal animals continue to focus on specific immune responses dominated by T cells using restricted sets of antigen receptors. These complementary strategies provide direct access to the dynamics of helper T-cell differentiation in vivo.
authors.affiliation: Duke University Medical Center, Department of Immunology, Durham, NC 27710, USA. mchey002@acpub.duke.edu
authors.forename: M G
authors.initials: MG
authors.lastname: McHeyzer-Williams
authors.forename: J D
authors.initials: JD
authors.lastname: Altman
authors.forename: M M
authors.initials: MM
authors.lastname: Davis
mesh_terms: D000818:Animals; D000939:Epitopes / Q000032:analysis* / Q000276:immunology*; D006801:Humans; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D000939:Epitopes