Gene therapy of cancer.
OBJECTIVE
To provide a review of the basic concepts and terminology of human genetics, the clinical application and risks of gene therapy, and ethical and societal issues.


METHODS
Review articles, research studies, and book chapters related to genetics and human gene therapy.


CONCLUSIONS
The genetic changes that play a role in the development of cancer have begun to be elucidated, and these discoveries have led to strategies to destroy cancers by correcting genetic defects or manipulating genes to induce tumoricidal activities. Gene therapy is a novel investigational intervention that is constantly evolving.


CONCLUSIONS
Oncology nurses will need an increased understanding of cellular biology, genetics, and genetics engineering. Major considerations for nursing practice include patient and family education, informed consent, side effects, and ethical and societal issues.
Robinson
K D
KD
Cancer Control/Community Outreach Services, University of Pittsburgh Cancer Institute, PA 15213, USA.
Abernathy
E
E
Conrad
K J
KJ
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003479:Curriculum; D004509:Education, Nursing, Continuing; D004992:Ethics, Medical; D004993:Ethics, Nursing; D015316:Genetic Therapy / Q000451:nursing*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000451:nursing / Q000628:therapy*; D009859:Oncology Nursing / Q000193:education