[The hypotensive effect of clonidine during direct and radiotelemetric recording of the arterial pressure in rats].
A hypotensive effect of clonidine in non-narcotized intact and aorta baro-denervated rats is studied under conditions of minimization of stress actions (radiotelemetry) and under standard conditions of direct recording arterial pressure (AP). Direct AP recording is shown to determine an increase in background AP in baro-denervated rats, but not in control rats. An increase in background AP level under conditions of direct recording is not accompanied with decreasing hypotensive effect of clonidine in baro-denervated rats.
Maĭorov
D N
DN
Murashev
A N
AN
Medvedev
O S
OS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001011:Aorta / Q000294:innervation; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000295:instrumentation / Q000379:methods; D003000:Clonidine / Q000494:pharmacology*; D003714:Denervation; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D011845:Radio; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology; D013686:Telemetry / Q000295:instrumentation / Q000379:methods
D000959:Antihypertensive Agents; D003000:Clonidine
Gipotenzivnyĭ éffekt klonidina v usloviiakh priamoĭ i radiotelemetricheskoĭ registratsii arterial'nogo davleniia u krys.