The copper complex of captopril is not a superoxide dismutase mimic. Artefacts in DMPO spin trapping.
The effect of captopril and of its copper complex on several superoxide-dependent reactions used to detect and assay superoxide dismutase activity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. In none of these systems were superoxide dismutase-like properties of captopril/Cu apparent. Captopril/Cu decreased the yield of DMPO-OH adducts generated by KO2 but this effect may be due to the acceleration of the decay of the adduct by captopril/Cu.
Bartosz
M
M
Department of Physiology, Military Medical University, lódź, Poland.
Kedziora
J
J
Bartosz
G
G
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D016477:Artifacts; D002216:Captopril / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D013113:Spin Labels; D019097:Spin Trapping / Q000379:methods*; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D013113:Spin Labels; D009580:Nitroblue Tetrazolium; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D003300:Copper; D002216:Captopril; D013482:Superoxide Dismutase