Morphometric analysis of fetal rat lung after the administration of Pyralene-3000.
The effects of the application of commercial low chlorinated PCB Pyralene-3000 on rat lung development during late gestation were studied. In the developing lungs (17.5 to 21.5 days) the volume density (Vv) of a particular compartment and length density of potential air spaces (Lv) were determined. Significant difference (p < 0.01) in epithelium to mesenchyme ratio (Epi/Mes) occurred between the control and treated groups on day 20.5 due to an increased volume proportion of mesenchyme (Vvmes) in the treated group suggesting a small delay in maturation. Decreased volume proportion of potential airspaces (Vvair) was observed on days 18.5 and 20.5. However, no differences were found on day 21.5 in any variables studied.
Vrecl
M
M
Institute of Anatomy, Histology and Embryology, Veterinary Faculty, University of Ljubljana, Slovenia.
Pogacnik
A
A
Lorger
J
J
Bavdek
S V
SV
D000818:Animals; D005260:Female; D008168:Lung / Q000033:anatomy & histology / Q000187:drug effects / Q000196:embryology*; D008176:Lung Volume Measurements; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
C013226:pyralene; D011078:Polychlorinated Biphenyls