Effects of dobutamine on left ventricular diastolic performance are attenuated in patients with systemic hypertension.
We measured Doppler echocardiographic diastolic parameter during infusion of low-dose dobutamine in 14 untreated hypertensive subjects and in 14 normal controls. Low-dose dobutamine accelerated left ventricular relaxation in normal controls but not in hypertensive subjects.
Iwakami
M
M
Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Hashimoto
Y
Y
Oniki
T
T
Numano
F
F
D000328:Adult; D002316:Cardiotonic Agents / Q000008:administration & dosage; D003971:Diastole / Q000187:drug effects; D004280:Dobutamine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D015150:Echocardiography, Doppler / Q000187:drug effects / Q000379:methods / Q000706:statistics & numerical data; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
D002316:Cardiotonic Agents; D004280:Dobutamine