[Pregnancy after hepatic transplantation: what is the maternal risk?].
OBJECTIVE
We report 7 pregnancies which occurred from 1988 to 1995 in 5 women who underwent liver transplantation. The immunosuppression regimen associated cyclosporine, azathioprine and prednisone.


RESULTS
Mean age at conception was 25. During pregnancy, cholestasis occurred in 2 women. None of the patients experienced rejection. An increase in serum creatinine was observed in 3 cases. Serum uric acid increased in the third trimester of pregnancy in 6 cases, associated with arterial hypertension in 3 cases. In 4 cases, toxemia led to premature delivery. Seven childbirths occurred between the 34th and 38th week of gestation, by vaginal delivery (n = 3) or caesarean section (n = 4). Newborn weights ranged from 1,350 g to 3,100 g. A favorable outcome was observed in all mothers, with a follow-up ranging from 2 months to 7 years after delivery.


CONCLUSIONS
These results suggest that a successful pregnancy is possible after liver transplantation in young women with normal hepatic function and treated with cyclosporine. The risk of toxemia is mainly related to renal function before pregnancy.
Pruvot
F R
FR
Service de Chirurgie, Hôpital Calmette, Lille.
Declerck
N
N
Valat-Rigot
A S
AS
Canva-Delcambre
V
V
Gambiez
L
L
Labalette
M
M
Gottrand
F
F
Noel
C
C
Puech
F
F
Paris
J C
JC
D000328:Adult; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation; D011184:Postoperative Period; D011247:Pregnancy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D012307:Risk Factors; D013997:Time Factors
D007166:Immunosuppressive Agents
Grossesse après transplantation hépatique: quel est le risque maternel?