Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade.
Neuroprotection against 100 microM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine- and voltage-activated channels may differ remarkably.
Lakics
V
V
CNS Pharmacology Laboratory, Chinoin Co. Ltd., Budapest, Hungary.
Molnár
P
P
Erdö
S L
SL
D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D008012:Lidocaine / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D026941:Sodium Channel Blockers; D014701:Veratridine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014748:Vinca Alkaloids / Q000494:pharmacology
D018696:Neuroprotective Agents; D026941:Sodium Channel Blockers; D014748:Vinca Alkaloids; D002220:Carbamazepine; C013983:vinpocetine; D010672:Phenytoin; D014701:Veratridine; D008012:Lidocaine