Cocaine-induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging.
We examined cocaine-mediated change in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine-mediated changes in extracellular dopamine concentrations.
Li
K L
KL
Department of Radiological Sciences, Deaconess Hospital, Harvard Medical School, Boston, MA 02215, USA.
Suojanen
J N
JN
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001810:Blood Volume / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000295:instrumentation*; D019028:Magnetic Resonance Imaging, Cine / Q000295:instrumentation*; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology
D003042:Cocaine; D004298:Dopamine