Stereotactically-guided craniotomy for cavernous angiomas presenting wit epilepsy.
With the wider availability of magnetic resonance imaging cavernous malformations are being recognised with increasing frequency in those patients presenting with intractable epilepsy. Surgical resection is the treatment of choice. However, because these lesions are usually small and may be located in eloquent areas stereotactic resection should be considered. Stereotactically-guided resection of pathologically verified cavernous angiograms was performed in 10 patients in this series presenting with epilepsy (8 males, 2 females, mean age 32 years). Eight patients presented with medically intractable epilepsy (5 complex partial seizures, 3 grand mal seizures). Of the remaining patients one experienced multiple episodes of haemorrhage and the other headaches (with a non-diagnostic scan) both in association with epilepsy. Pre-operative localisation of the motor strip was determined in one case by functional MRI. Following resection of these lesions all patients experienced improved seizure control with a mean follow-up period of 22 months. The mean postoperative hospital stay was 5.1 days with no surgical complications recorded. We conclude that stereotactically-guided resection offers significant advantages in the management of cavernous malformations. Surgical indications for operative resection would include medically refractory epilepsy, repeated haemorrhage and those cases where there is diagnostic uncertainty.
Casey
A T
AT
National Hospital for Neurology and Neurosurgery, London, U.K.
Thomas
D G
DG
Harkness
W F
WF
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000601:surgery; D002648:Child; D003399:Craniotomy; D017029:Epilepsy, Complex Partial / Q000209:etiology / Q000601:surgery*; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology / Q000601:surgery*; D005260:Female; D006392:Hemangioma, Cavernous / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000209:etiology; D013238:Stereotaxic Techniques; D016896:Treatment Outcome