title: The effect of steroid on thallium-201 uptake by malignant gliomas.
abstract: In order to assess the effect of steroid on thallium-201 uptake by glioma, 201Tl single-photon emission tomography was performed before and after steroid administration in four patients with recurrent malignant glioma. After steroid administration the 201Tl index, expressed as the ratio of 201Tl uptake in the tumour to that in the contralateral cerebral hemisphere, was 0.77+/-0.11 of the value before steroid (mean+/-SD: P<0.05 by paired t test). The 201Tl index has been used as a possible indicator for the differentiation of malignant gliomas from relatively benign tumours or radiation necrosis. The present results indicate that the effect of steroid has to be taken into account when semi-quantitative analysis, e.g. by means of the 201Tl index, is used in patients with brain tumours.
authors: Division of Neurological Surgery, Chiba Cancer Center Hospital, Chiba, Japan.
authors: H
authors: H
authors: Namba
authors: T
authors: T
authors: Togawa
authors: N
authors: N
authors: Yui
authors: M
authors: M
authors: Yanagisawa
authors: F
authors: F
authors: Kinoshita
authors: Y
authors: Y
authors: Iwadate
authors: K
authors: K
authors: Ohsato
authors: K
authors: K
authors: Sueyoshi
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000188:drug therapy; D015173:Supratentorial Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013794:Thallium Radioisotopes; D003907:Dexamethasone