Ascaris suum: ultrastructural effect of in vitro albendazole therapy.
The effect of albendazole therapy on adult Ascaris suum was examined using transmission electron microscopy. The drug induced prominent ultrastructural changes which included the presence of necrotic dense bodies, myelin whorls which appeared to represent various stages of lysosomal formation and autolysis, disruption and erosion of the microvilli. The effects were mainly confined to the central region of the intestinal epithelial cells.
Magambo
J K
JK
Department of Zoology, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D017165:Ascaris suum / Q000187:drug effects* / Q000648:ultrastructure*; D004353:Drug Evaluation, Preclinical; D008247:Lysosomes / Q000648:ultrastructure; D017348:Microscopy, Electron, Scanning Transmission; D008871:Microvilli / Q000648:ultrastructure; D013552:Swine / Q000469:parasitology
D000871:Anthelmintics; D015766:Albendazole