A new norcembranoid dimer from the red sea soft coral Sinularia gardineri.
A study of Sinularia gardineri (Pratt) (Alcyoniidae), collected in the Red Sea, revealed a new heptacyclic norcembranoid dimer singardin (1). The structure of singardin was deduced by spectroscopic analysis. A known sesquiterpene, guaianediol (2), and the known cembranolides (1R,5S,8R,10S,11R)-11-hydroxy-1-isoprenyl-8-methyl-3,6-dioxo -5,8-epoxycyclotetradec-12-ene 10,12-carbolactone (5-epi-sinuleptolide) and sinuleptolide were also isolated. Compounds 1 and 2 show cytotoxicity to murine leukemia (P-388), human lung carcinoma (A-549), human colon carcinoma (HT-29), and human melanoma cells (MEL-28).
el Sayed
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Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677, USA.
Hamann
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D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D003455:Cryptococcus neoformans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C101809:singardin