[Selective arterial catheterization in the management of drug-resistant choriocarcinoma].
OBJECTIVE
In order to save the life of the patients with drug-resistant choriocarcinoma due to improper treatment, selective arterial catheterization was used.


METHODS
All the 71 cases were treated with systemic chemotherapy together with pelvic selective arterial chemotherapy. 5 of them had arterial chemotherapy plus arterial embolization for hemorrhage. In 13 patients who had lung metastasis, intraarterial injection of methotrexate (MTX) through bronchial arterial was added.


RESULTS
55 of 71 (77.8%) achieved complete remission and 10 (14.1%) had partial remission. One patient failed to follow-up. 5 died of various causes during hospitalization. On Follow-up 12 had survived for more than 5 years with no signs of recurrence. 2 of them had childbirth after recovery.


CONCLUSIONS
Systemic intravenous infusion chemotherapy in combination with arterial chemotherapy is useful for drug-resistant choriocarcinoma. In patients with intraperitoneal hemorrhage caused by tumor rupture, selective arterial embolization should be used as emergency treatment to effectively control the bleeding, in order that patients will have a chance for further chemotherapy.
Yang
X
X
Peking Union Medical College Hospital, Beijing.
Yang
N
N
Song
H
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D005472:Fluorouracil; D008727:Methotrexate