Effects of ibuprofen on airway vascular response to cotton smoke injury.
We studied the effects of ibuprofen on bronchial blood flow and myocardial function after inhalation injury. Sheep (n = 12) were chronically instrumented with cardiovascular and pulmonary catheters. After 5 days of recovery period, baseline data were collected and the sheep were divided into two groups. Group S (n = 6) were insufflated with 48 breaths of cotton smoke; while group I (n = 6) were pretreated with ibuprofen (12mg/kg bolus followed by 3 mg/kg/h continuous infusion for 24 h) and challenged with the same dose of smoke. All the animals were studied for 24h. Bronchial blood flow increased significantly in both groups throughout the experimental period; while stroke volume as well as right and left ventricular stroke work indices of both groups were significantly decreased (group I worse than group S) in the second half of the experimental period. These data suggest that vasodilatory prostaglandins do not play a major role in the bronchial vascular response to smoke inhalation injury and myocardial depression seen post injury is worse in animals treated with ibuprofen.
Abdi
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Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
Traber
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Herndon
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Rogers
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001981:Bronchial Arteries / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D003368:Gossypium; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012756:Sheep; D015208:Smoke Inhalation Injury / Q000503:physiopathology*; D013318:Stroke Volume / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D007052:Ibuprofen