[The role of endothelin-1 and tumor necrosis factor-alpha in the development of asthma sarcoidosis].
In order to investigate the interaction of endothelin-1 (ET-1) and tumor necrosis factor-alpha (TNF-alpha) and their activity in the pathogenesis of asthma, ET-1 plasma and BALF levels were measured, and the amount of TNF-alpha released from alveolar macrophage (AM) was also tested. As in vitro the airway smooth muscle cells were stimulated with TNF-Alpha, the release of ET-1 was also observed. The results showed that the amount of ET-1, TNF-alpha were both increased than in the control group, at the same time, TNF-alpha could stimulate smooth muscle cells to secrete ET-1. We concluded that the release of ET-1 induced by TNF-alpha might play a certain role in development of airway hyperresponsiveness and airway remodeling.
Liu
Z
Z
Guangzhou Institute of Respiratory Disease.
Xu
J
J
Zhang
N
N
D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002478:Cells, Cultured; D016232:Endothelins / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000494:pharmacology
D016232:Endothelins; D014409:Tumor Necrosis Factor-alpha