Protein-losing gastropathy associated with cytomegalovirus: a rare and late complication of allogeneic bone marrow transplantation.
A 36-year-old women with chronic myelogenous leukemia in first chronic phase received a bone marrow transplant from her HLA-identical brother. The preparatory regimen consisted of total body irradiation (10 Gy) and cyclophosphamide (60 mg/kg for 2 days). Full engraftment was achieved and the woman was monitored as an outpatient after discharge from hospital on day 35. One year after BMT, while she was on cyclosporin A and steroids because of chronic graft-versus-host disease, the patient developed protein-losing gastropathy associated with cytomegalovirus infection (with no gastrointestinal symptoms), which regressed spontaneously in 4 weeks.
Pinho Vaz
C
C
Bone Marrow Transplantation Unit, Institut Gustave Roussy, Villejuif, France.
Ibrahim
A
A
Avila Garavito
A
A
Vantelon
J M
JM
Bourhis
J H
JH
Charnoze
I
I
Buffet
C
C
Pico
J L
JL
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005758:Gastritis, Hypertrophic / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000628:therapy; D008297:Male; D011504:Protein-Losing Enteropathies / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D014184:Transplantation, Homologous