[Effect of a peptide from the mollusk optical ganglia on macrophage functional activity].
Gangliin (tinrostim), a novel peptide isolated from the nervous tissue of the food mollusks, was investigated with respect to its effect on the cells of the system of the mononuclear phagocytes. It was shown to have a high protective action in some experimental infections. One of the main mechanisms of the gangliin action was the increase of the functional activity of the cells of the system of the mononuclear phagocytes. It was demonstrated that gangliin induced a decrease in the activity of 5'-nucleotidase and increased the absorption and digestive functions of the macrophage.
Besednova
N N
NN
Gazha
A K
AK
Epshteĭn
L M
LM
Borovskaia
G A
GA
Kirillicheva
G B
GB
D000818:Animals; D017952:Ganglia, Invertebrate / Q000737:chemistry*; D017950:Ganglia, Sensory / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008974:Mollusca / Q000737:chemistry*; D009479:Neuropeptides / Q000494:pharmacology*; D012481:Salmonella Infections, Animal / Q000517:prevention & control; D014795:Visual Pathways / Q000737:chemistry*
D009479:Neuropeptides
Deĭstvie peptida iz opticheskikh gangliev molliuskov na funktsional'nuiu aktivnost' makrofagov.