The influence of Microgynon and Diane-35, two sub-fifty ovulation inhibitors, on voice function in women.
The early days of oral contraceptives showed some evidence that these medications may have caused undesirable side effects on the voice, mainly in terms of virilization. In a random study carried out at the university hospitals of Jena and Berlin (Charité), two more recent drugs were tested in this regard, one containing cyproterone acetate (Diane-35) and the other one levonorgestrel (Microgynon), both from Schering. Ninety-one patients took part in extensive clinical and instrumental phoniatric investigations of voice function over a period of one year. No significant side effects on the voice could be proven for the two preparations. Gynecological and clinical effects of both Diane-35 and Microgynon were similar during the one-year study period. Women taking Diane-35 had less intracyclic bleedings and amenorrhea. Also, acne was more favorably influenced by Diane-35.
Wendler
J
J
Dept. of Phoniatry and Pediatric Audiology, ENT Clinic Charite, University Hospital of Berlin, Germany.
Siegert
C
C
Schelhorn
P
P
Klinger
G
G
Gurr
S
S
Kaufmann
J
J
Aydinlik
S
S
Braunschweig
T
T
D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D017373:Cyproterone Acetate / Q000494:pharmacology*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects*; D010699:Phonation / Q000187:drug effects*; D016037:Single-Blind Method
D000726:Androgen Antagonists; D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C032640:Cyproterone acetate, ethinyl estradiol drug combination; D019304:Ethinyl Estradiol-Norgestrel Combination