Chemokines: progress toward identifying molecular targets for therapeutic agents.
Leukocyte migration towards injury sites is directed by the interaction of chemokines with their receptors. The stages of migration are closely regulated events that involve chemokine-induced leukocyte adhesion, diapedesis and homing. Current research suggests a pathophysiological role for chemokines in diverse inflammatory states arising from viral, bacterial and parasitic infection, allergic and asthmatic reactions, atherosclerosis and arthritis. A role for chemokines in tumor immunity and angiogenesis has recently been demonstrated. A basis for the rational design of chemokine antagonists is emerging from a knowledge of tertiary structures and mutational analysis of chemokine ligands and receptors. Here, we discuss advances in knowledge about chemokine structure and function, with emphasis on potential therapeutic agents.
Howard
O M
OM
SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201, USA.
Ben-Baruch
A
A
Oppenheim
J J
JJ
D001161:Arteriosclerosis / Q000503:physiopathology / Q000628:therapy; D001168:Arthritis / Q000503:physiopathology / Q000628:therapy; D001249:Asthma / Q000503:physiopathology / Q000628:therapy; D001424:Bacterial Infections / Q000503:physiopathology / Q000628:therapy; D018925:Chemokines / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology / Q000628:therapy; D007249:Inflammation; D010272:Parasitic Diseases / Q000503:physiopathology / Q000628:therapy; D011971:Receptors, Immunologic / Q000737:chemistry / Q000502:physiology*; D011994:Recombinant Proteins / Q000737:chemistry / Q000627:therapeutic use*; D014777:Virus Diseases / Q000503:physiopathology / Q000628:therapy
D018925:Chemokines; D011971:Receptors, Immunologic; D011994:Recombinant Proteins