Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant.
A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymphoid-associated antigens (CD10 and CD19) but not myeloid-associated antigens (CD13, CD14, and CD33). These findings suggest that some cases of infantile CMML are clonal disorders arising in a pluripotent stem cell that can also differentiate along the lymphoid cell lineage.
Yamamoto
M
M
Department of Pediatrics, Hyogo College of Medicine, Japan.
Nakagawa
M
M
Ichimura
N
N
Ohtsuki
F
F
Ohtsuka
Y
Y
Tsujino
Y
Y
Tanaka
A
A
Kamiya
T
T
Wada
H
H
D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007223:Infant; D015477:Leukemia, Myelomonocytic, Chronic / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000473:pathology*
D015703:Antigens, CD