Morphological and X-ray microanalytical changes in mammalian tissue after overhydration with irrigating fluids.
We compared morphological changes in the heart, brain, liver and kidneys after giving 100 ml/kg of 5 irrigating fluids by intravenous infusion to 30 rabbits. Glycine 1.5% and 1.0%, both with ethanol 1% as a tracer for absorption, received the highest scores for tissue swelling and were sometimes followed by focal necrosis and an inflammatory cell reaction in subendocardial areas of the heart. Three rabbits died shortly after infusion of glycine 1.5% + ethanol 1%, the deaths being preceded by bradycardia and an irregular cardiac rhythm. This solution also lowered the intracellular potassium and chlorine content as shown by X-ray microanalysis of myocardial cells. Mannitol 3% + ethanol 1% produced the most favorable outcome in our evaluation, with the lowest scores for tissue swelling, while sorbitol 2% + mannitol 1% and normal saline took intermediate positions.
Hahn
R G
RG
Department of Anaesthesia, Stockholm Södra Hospital, Sweden.
Nennesmo
I
I
Rajs
J
J
Sundelin
B
B
Wróblewski
R
R
Zhang
W
W
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002713:Chlorine / Q000378:metabolism; D004234:Diuretics, Osmotic / Q000008:administration & dosage / Q000633:toxicity; D004357:Drug Synergism; D004562:Electrocardiography / Q000187:drug effects; D004577:Electron Probe Microanalysis; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity; D005998:Glycine / Q000008:administration & dosage / Q000633:toxicity; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000633:toxicity; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D011897:Random Allocation; D012997:Solvents / Q000633:toxicity; D013012:Sorbitol / Q000008:administration & dosage / Q000633:toxicity; D007507:Therapeutic Irrigation / Q000009:adverse effects
D004234:Diuretics, Osmotic; D012997:Solvents; D000431:Ethanol; D008353:Mannitol; D002713:Chlorine; D013012:Sorbitol; D011188:Potassium; D005998:Glycine