Analgesics and chronic renal disease.
Intake of analgesics has been associated with the presence of chronic renal diseases in a number of studies. Phenacetin was the first drug to be linked with chronic renal disease. Four out of five case-control studies that have examined this issue have also demonstrated an association of acetaminophen use with renal disease. Non-steroidal anti-inflammatory drugs have not been available for a long enough time to evaluate risk associated with their use. Several studies suggest that mixtures of analgesics are most harmful to the Kidney. The National Kidney Foundation recently issued a position paper on analgesics and the kidney that provides guidance to patients and providers.
Klag
M J
MJ
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2223, USA.
Whelton
P K
PK
Perneger
T V
TV
D000700:Analgesics / Q000009:adverse effects*; D016022:Case-Control Studies; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D011446:Prospective Studies; D012307:Risk Factors
D000700:Analgesics