title: Experimental impeller fragmentation of iliocaval thrombosis under tulip filter protection: preliminary results.
abstract: OBJECTIVE
  To assess the efficacy of catheter fragmentation of massive caval thrombosis and of filter protection against procedure-related pulmonary embolism.
  
  
  METHODS
  In 10 sheep, a self-expanding tulip-shaped filter made from Wallstent mesh (diameter 25 mm) was introduced from the right jugular approach into the proximal inferior vena cava. Experimentally induced massive iliocaval thrombosis was fragmented by an impeller catheter (expanded diameter 14 mm), which was advanced coaxially through the sheath of the expanded filter. Post-procedural cavography and pulmonary angiography were performed to document the extent of caval recanalization and pulmonary embolism.
  
  
  RESULTS
  In all cases, impeller fragmentation cleared the inferior vena cava and the iliac veins of thrombi completely. Fragments washed downstream were trapped in the filter. In two of the first cases, parts of the clots caused pulmonary embolism before the filter was in place. Further events were avoided by a modification of the experimental setup. Except for some small peripheral perfusion defects in two cases, pulmonary angiograms did not show any incidence of pulmonary embolism.
  
  
  CONCLUSIONS
  Our preliminary results suggest that impeller fragmentation of iliocaval thrombi under tulip filter protection is effective and does not cause significant pulmonary embolism.
authors: Department of Diagnostic Radiology, University of Technology, Klinikum Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany.
authors: T
authors: T
authors: Schmitz-Rode
authors: D
authors: D
authors: Vorwerk
authors: K
authors: K
authors: Schürmann
authors: R W
authors: RW
authors: Günther
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D004867:Equipment Design; D007084:Iliac Vein; D011655:Pulmonary Embolism / Q000517:prevention & control; D011859:Radiography; D012756:Sheep; D013193:Stainless Steel; D017131:Thrombectomy / Q000295:instrumentation* / Q000379:methods; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000601:surgery*; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior
chemical_list: D013193:Stainless Steel