Nitric oxide synthase levels in obese Zucker rats.
Nitric oxide has been demonstrated to play a role in the modulation of food intake. The Zucker fatty rat is an autosomal recessive genetic model of obesity. We measured nitric oxide synthase (NOS) in the hypothalamus and fundus of the stomach in Zucker (fa/fa) rats and their lean littermate controls (fa/?). NOS activity was decreased in both the hypothalamus and the fundus of the Zucker (fa/fa) rats compared to the littermate controls.
Morley
J E
JE
Geriatric Research, Education and Clinical Center, St. Louis VA Medical Center, St. Louis, MO, USA.
Mattammal
M B
MB
D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker
D019001:Nitric Oxide Synthase