title: Establishment of the hereditary cataract rat strain (SCR) and genetic analysis.
abstract: The Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo death rate was 25%. Genetic analysis of cataract formation in the SCR was studied by breeding experiments with strains such as NC1, BUF, ACI, AD3, and normal SCR rats. No sex-based differences in cataract appearance were observed in any of the progeny. These results confirmed our hypotheses that two autosomal genes, a recessive cataract gene (ctr1), and a normal allele of a dominant cataract gene with a recessive lethal trait (Ctr2(1)) for provisional designations participated in cataract genesis in SCR (ctr1/ctr1, Ctr2(1)/Ctr2) rats. One recessive cataract gene was maintained in normal SCR, NC1 and NC2 (ctr1/ctr1, Ctr2/Ctr2) rats. The same recessive cataract gene was retained in the albumin-deficient brown hooded rat strain AD3 (ctr1/ctr1, Ctr2/Ctr2).
authors: Tokyo Metropolitan Institute of Gerontology, Japan.
authors: S
authors: S
authors: Shumiya
mesh_terms: D000818:Animals; D001947:Breeding; D002386:Cataract / Q000235:genetics / Q000662:veterinary*; D004622:Embryo, Mammalian / Q000473:pathology; D005260:Female; D005328:Fetal Viability; D015994:Incidence; D007905:Lens Diseases / Q000235:genetics / Q000662:veterinary*; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000196:embryology / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics*