title: Boron neutron capture irradiation of the rat spinal cord: histopathological evidence of a vascular-mediated pathogenesis.
abstract: A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times in rats developing myelopathy. Considered overall, the pathology of the spinal cord after BNC irradiation was comparable with that reported previously after X irradiation of the spinal cord in the identical strain of rat. When BSH was used as the neutron capture agent, the biologically effective dose of radiation delivered to the CNS parenchyma was a factor of -2.7 lower than that delivered to the vascular endothelium. In effect, the blood vessels were selectively irradiated using this BNC modality. The resultant pathology was similar to that observed after irradiation with thermal neutrons alone or in the presence of BPA, situations in which the CNS vasculature was not selectively irradiated. This points to the vascular endothelium as being the critical target cell population, damage to which results in the development of the lesions seen in the spinal cord after BNC irradiation and, by inference, after irradiation with more conventional modalities.
authors: The Research Institute, Churchill Hospital, Oxford, United Kingdom.
authors: G M
authors: GM
authors: Morris
authors: J A
authors: JA
authors: Coderre
authors: A
authors: A
authors: Bywaters
authors: E
authors: E
authors: Whitehouse
authors: J W
authors: JW
authors: Hopewell
mesh_terms: D000512:Alpha Particles; D000818:Animals; D001808:Blood Vessels / Q000473:pathology / Q000528:radiation effects; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology*; D001894:Borohydrides; D001896:Boron Compounds; D016754:Boron Neutron Capture Therapy; D005354:Fibrosarcoma / Q000209:etiology / Q000473:pathology / Q000556:secondary*; D005720:Gamma Rays; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D009502:Neutrons; D010649:Phenylalanine / Q000031:analogs & derivatives; D017785:Photons; D011522:Protons; D011838:Radiation-Sensitizing Agents; D051381:Rats; D011916:Rats, Inbred F344; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology / Q000528:radiation effects*; D013120:Spinal Cord Neoplasms / Q000209:etiology / Q000473:pathology / Q000556:secondary*; D013438:Sulfhydryl Compounds; D014965:X-Rays
chemical_list: D001894:Borohydrides; D001896:Boron Compounds; D011522:Protons; D011838:Radiation-Sensitizing Agents; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D010649:Phenylalanine; C033685:4-boronophenylalanine