Comparative hypocholesterolemic effects of six vegetable oils in cholesterol-fed rat.
The hypocholesterolemic efficacies of various polyunsaturated fatty acids were compared in rats given cholesterol-enriched diets. Oenothera biennis Linn oil (OBLO, linoleic + gamma-linolenic), sunflower oil (linoleic), palm oil (PLO, oleic + linoleic), soybean oil (linoleic + alpha-linolenic), high-oleic safflower oil (oleic + linoleic), or mixed oil (linoleic + alpha-linolenic) was added to the diet at 200 g/kg (20% groups). OBLO was also added at 100 g/kg diet (10% group). The serum total and very low density lipoprotein + intermediate lipoprotein + low density lipoprotein cholesterol concentrations of the 10 and 20% OBLO groups were consistently lower than those in the other groups. The liver cholesterol concentration in the PLO group was lower in all groups. The liver cholesterol concentrations in the 10 and 20% OBLO groups were also lower than in the other groups. There were no significant differences in the fecal neutral sterol and bile acid extraction among groups.
Fukushima
M
M
Department of Bioresource Chemistry, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Akiba
S
S
Nakano
M
M
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D015243:Cholesterol, VLDL / Q000097:blood / Q000187:drug effects; D005227:Fatty Acids / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D019787:Linoleic Acid; D008041:Linoleic Acids; D008074:Lipoproteins / Q000097:blood* / Q000494:pharmacology; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D000073878:Palm Oil; D010713:Phosphatidylcholines / Q000097:blood / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013024:Soybean Oil; D013256:Steroids / Q000032:analysis; D000074242:Sunflower Oil; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects; D017962:alpha-Linolenic Acid; D017965:gamma-Linolenic Acid
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008074:Lipoproteins; D010713:Phosphatidylcholines; D010938:Plant Oils; D013256:Steroids; D000074242:Sunflower Oil; D014280:Triglycerides; C030104:lipoprotein cholesterol; D017962:alpha-Linolenic Acid; D000073878:Palm Oil; D017965:gamma-Linolenic Acid; D013024:Soybean Oil; D002784:Cholesterol; D019787:Linoleic Acid