title: [Pulmonary involvement of collagen vascular diseases: studies on prognostic factors from basic and clinical viewpoints].
abstract: In 715 patients with collagen vascular diseases, interstitial lung disease and pulmonary hypertension were found to be important causes of death (37.5% and 6%, respectively). The prognosis of interstitial lung disease associated with collagen vascular disease was better than that of idiopathic interstitial pneumonia; patients with the latter were more likely to experience exacerbations. A distinct subgroup of patients with dermatomyositis and interstitial lung disease with a rapidly progressive course was characterized by mild muscle symptoms, low levels of creatine phosphokinase and negative tests for anti-Jo-1 antibody. CT scores and analysis of bronchoalveolar lavage fluid proved to be of some value in predicting outcome. Measurement of IL-6 in bronchoalveolar lavage fluid and local immunostaining for this pro-inflammatory cytokine were helpful in evaluating responses to therapy.
authors: Department of Internal Medicine Therapy, University School of Medicine, Hamamatsu, Japan.
authors: H
authors: H
authors: Takizawa
authors: N
authors: N
authors: Suzuki
authors: T
authors: T
authors: Yanagawa
authors: H
authors: H
authors: Okazaki
authors: M
authors: M
authors: Satoh
authors: N
authors: N
authors: Akiyama
authors: T
authors: T
authors: Kohyama
authors: K
authors: K
authors: Ito
authors: T
authors: T
authors: Oka
authors: K
authors: K
authors: Hayakawa
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016516:CD4-CD8 Ratio; D003095:Collagen Diseases / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000503:physiopathology*; D011379:Prognosis; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D015850:Interleukin-6; C046750:Jo-1 antibody