Effects of thyroid hormone treatment on 31P-NMR spectroscopy of muscle and on nerve conduction studies in a patient with long-standing severe hypothyroidism.
Hypothyroidism exerts a significant effect on several body systems, including the functioning of muscle and nerve. Described here is the case of a severely hypothyroid patient with weakness and numbness of the legs who showed marked clinical improvement with thyroid hormone treatment. Concurrently obtained phosphorus 31-nuclear magnetic resonance (NRM) spectra and nerve conduction studies showed changes in muscle phosphorus metabolism with increases in conduction velocities. Phosphorus 31-NMR spectroscopy is useful for evaluating metabolism in muscle in hypothyroid patients.
Reeves
R R
RR
Departments of Psychiatry & Neurology, School of Medicine, Louisiana State University, Shreveport 71103-4209, USA.
D004576:Electromyography / Q000379:methods; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy* / Q000503:physiopathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects*; D010758:Phosphorus; D012680:Sensitivity and Specificity; D013963:Thyroid Hormones / Q000627:therapeutic use*
D013963:Thyroid Hormones; D010758:Phosphorus