Effect of subclinical lead toxicity on the immune response of chickens to Newcastle disease virus vaccine.
The effect of lead acetate (20 and 40 mg kg-1 bodyweight daily) administered via the crop from day old to 56 days of age on the immune response to Newcastle disease virus vaccine (NDVV, La Sota strain) was studied in 354 Lohman chickens. Lead decreased the mitogenic response of peripheral blood lymphocytes (PBL) to phytohaemagglutinin-P (PHA-P) in birds vaccinated with NDVV. It also decreased the weights of the bursa of Fabricius, the thymus glands and the spleen relative to bodyweight. Lead administration decreased the antibody titre to NDVV in the vaccinated groups. The percentage mortality due to a challenge with a virulent velogenic Newcastle disease virus was higher in the lead intoxicated birds.
Youssef
S A
SA
Department of Pharmacology, Cairo University, Giza, Egypt.
El-Sanousi
A A
AA
Afifi
N A
NA
El Brawy
A M
AM
D000818:Animals; D001835:Body Weight; D002645:Chickens; D006385:Hemagglutination Inhibition Tests; D007855:Lead Poisoning / Q000276:immunology*; D008297:Male; D009521:Newcastle Disease / Q000276:immunology* / Q000517:prevention & control; D009522:Newcastle disease virus / Q000276:immunology*; D009942:Organometallic Compounds; D013997:Time Factors; D014765:Viral Vaccines
D009942:Organometallic Compounds; D014765:Viral Vaccines; C008261:lead acetate