Dyslipidemia in renal disease.
In summary, dyslipidemia is a common feature of various renal syndromes. Whether this perturbed lipid metabolism results in accelerated atherosclerosis and increased cerebrovascular and cardiovascular morbidity and mortality remains a subject of inquiry. Also undefined is the role of dyslipidemia in the progression of renal injury. The malnutrition that becomes a dominant morbid feature in patients on maintenance renal replacement therapy provides a caveat against aggressive intervention for modest hyperlipidemia once dialysis is instituted. Individualized assessment of end organ atherosclerotic disease and cardiovascular risk factors should form the basis for modification of the treatment plan (ie, pharmacological intervention) should nonpharmacological means prove ineffective.
Mittman
N
N
Division of Nephrology, Long Island College Hospital, Brooklyn, NY 11201, USA.
Avram
M M
MM
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology* / Q000628:therapy; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D009748:Nutrition Disorders / Q000150:complications; D006435:Renal Dialysis
D008055:Lipids; D017270:Lipoprotein(a)