title: The hemagglutinin of Staphylococcus saprophyticus is a major adhesin for uroepithelial cells.
abstract: The 160-kDa hemagglutinin of Staphylococcus saprophyticus also serves as a fibronectin-binding protein, and the two activities may be present on different parts of the molecule. Bacteria expressing the 160-kDa hemagglutinin bound in large numbers to histological sections of human ureters, whereas nonhemagglutinating bacteria did not bind. Binding was decreased by an antiserum to the 160-kDa protein and by a preparation of sheep erythrocyte membranes. Fibronectin had no effect. We therefore conclude that binding of S. saprophyticus to uroepithelial cells is mediated by the hemagglutinating activity of the 160-kDa surface protein.
authors: Department of Medical Microbiology and Hygiene, University of Mainz, Germany.
authors: H G
authors: HG
authors: Meyer
authors: U
authors: U
authors: Wengler-Becker
authors: S G
authors: SG
authors: Gatermann
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D004848:Epithelium / Q000382:microbiology; D004910:Erythrocyte Membrane / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006388:Hemagglutinins / Q000378:metabolism*; D006801:Humans; D012756:Sheep; D013210:Staphylococcus / Q000472:pathogenicity*; D014513:Ureter / Q000382:microbiology*
chemical_list: D005353:Fibronectins; D006388:Hemagglutinins