VCAM-1 expression and leukocyte trafficking to the CNS occur early in infection with pathogenic isolates of SIV.
This study reports on the endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) in the central nervous system (CNS) early after experimental infection of rhesus monkeys (Macaca mulatta) with pathogenic and nonpathogenic simian immunodeficiency virus (SIV). Diffuse endothelial expression of VCAM-1 was observed in the CNS in all animals receiving pathogenic SIV. These findings demonstrate the rapidity with which pathogenic SIV is able to enter the CNS and induce endothelial cell activation.
Sasseville
V G
VG
Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA, 01772-9102, USA.
Lane
J H
JH
Walsh
D
D
Ringler
D J
DJ
Lackner
A A
AA
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology / Q000821:virology*; D002555:Cerebrospinal Fluid / Q000821:virology; D004730:Endothelium, Vascular / Q000276:immunology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000473:pathology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification; D013116:Spinal Cord / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
D000914:Antibodies, Viral; D019010:Vascular Cell Adhesion Molecule-1