Dermal absorption of cis-1,3-dichloropropene vapour: human experimental exposure.
1. The relevance of skin absorption of cis-1,3-dichloropropene (cis-1,3-DCP) vapour as a route of entry compared to inhalatory uptake has been assessed in human volunteers under controlled exposure conditions. 2. Five adults (four males and one female) were dermally exposed on the forearm and hand during 45 min to 86 mg/m3 cis-1,3-DCP. 3. Dermal uptake was assessed by determination of the main cis-1,3-DCP metabolite in urine: the mercapturic acid conjugate of cis-1,3-DCP (cis-1,3-DCP-MA). 4. When whole-body dermal exposure to vapour is compared to inhalatory exposure, the uptake through the skin is estimated to be about 2-5% of the inhalatory absorption.
Kezić
S
S
Coronel Laboratory, University of Amsterdam, The Netherlands.
Monster
A C
AC
Verplanke
A J
AJ
de Wolff
F A
FA
D000111:Acetylcysteine / Q000652:urine; D000287:Administration, Topical; D000328:Adult; D000498:Allyl Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D005542:Forearm; D006207:Half-Life; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D008875:Middle Aged; D012869:Skin Absorption / Q000187:drug effects*; D013237:Stereoisomerism; D014835:Volatilization
D000498:Allyl Compounds; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; C023891:1,3-dichloro-1-propene; D000111:Acetylcysteine