Participation of IL-2 and direct cell cytotoxicity in the modulation of GvH reaction in mice infected with Listeria innocua.
Listeria innocua can intensify the development of local GvH reaction in a semiallogeneic system in mice. This phenomenon is observed in (BALB/c x AKR)F1 mice intraperitoneally injected with the live bacteria on the 7th day before the transfer of BALB/c spleen cells. The local GvH reaction develops as strongly as in normal hybrid recipients given the parental cell graft in the presence of exogenous interleukin 2 (IL-2). The development of the reaction is associated with an intensive increase of the direct cytotoxicity of lymph node cells which is also markedly enhanced after the bacteria injection itself. IL-2 seems to play a relevant role in the development of local GvH reaction in L. innocua-injected mice.
Gościcka
T
T
Department of Immunology, University of Lódź, Poland.
Walencka
M
M
Szeliga
J
J
Bloch
M
M
Dziadek
B
B
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D006086:Graft vs Host Disease; D007376:Interleukin-2 / Q000494:pharmacology*; D008088:Listeriosis / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C
D007376:Interleukin-2