[Effect of lomefloxacin on luminol-dependent chemiluminescence and adhesion of leukocytes].
The in vitro effect of lomefloxacin within the wide dose ranges from 0.1 to 100 micrograms/ml on luminol-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied under two different conditions: during the cell incubation in the presence of various concentrations of the drug and after the cell washing to remove lomefloxacin. In concentrations of 10 and 100 micrograms/ml the drug inhibited the response under the both conditions while in a concentration of 1 microgram/ml it stimulated the chemiluminescence. In concentrations of 0.1 to 100 micrograms/ml lomefloxacin stimulated the leukocyte adherence. The highest stimulation was observed with the use of the drug in a concentration of 1 microgram/ml.
Iordanova
A I
AI
Nikitin
A V
AV
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D024841:Fluoroquinolones; D006168:Guinea Pigs; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects*; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D008165:Luminol; C053091:lomefloxacin
Vliianie lomefloksatsina na liuminolzavisimuiu khemiliuminestsentsiiu i adgeziiu leĭkotsitov.