[Effects of ACM sequential chemotherapy on ovarian function in trophoblastic tumors].
OBJECTIVE
To study the changes of ovarian function during and after ACM sequential chemotherapy on trophoblastic tumors.


METHODS
17 patients with trophoblastic tumors, received totally 48 cycles of ACM chemotherapy. Of these, 7 underwent hysterotomy and focal ectomy and ovarian biopsy. Changes of menstruation and BBT were observed. beta-hCG, E2, FSH and LH were assayed and histological and immunohistochemical studies in ovaries biopsied were made.


RESULTS
Amenorrhea and anovulatory BBT were predominant at the onset of chemotherapy and high level of beta-hCG. Following chemotherapy and decrease of beta-hCG, menstruation recovered with less amount and BBT transformed into ovulatory types with shorter luteal phase. The E2 level appeared to be lower and the FSH and LH level higher. The different kinds of follicles were decreased, but estrogen receptors unchanged. Follow-up showed that ovarian function of 12 of the 17 patients returned to normal in one year.


CONCLUSIONS
ACM chemotherapy suppresses ovarian function mildly and temporarily. Trophoblastic tumor also affects ovarian function. ACM chemotherapy seems to be suitable for young patients with trophoblastic tumors who desire child-bearing.
Shi
Y
Y
Women's Hospital, Zhejiang Medical University, Hangzhou.
Xie
X
X
Zhao
C
C
D000328:Adult; D000858:Anovulation / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D010053:Ovary / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D003609:Dactinomycin; D003520:Cyclophosphamide; D008727:Methotrexate