7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid.
1. The effects of 7-chlorokynurenic acid were studied against the epileptiform and neurotoxic effects due to the non-NMDA excitatory amino acid, kainic acid, in rat hippocampal slices. 2. Slice perfusion with 7-chlorokynurenic acid (100 microM), significantly (p < 0.05) decreased the duration of the CA1 epileptiform bursting due to 1 microM kainic acid. 3. Slice perfusion with 7-chlorokynurenic acid (100 microM) significantly (p < 0.05) increased the probability of recovery of the CA1 population spike after a neurotoxic concentration (12 microM) of kainic acid. 4. The results indicate that 7-chlorokynurenic acid affects, with a similar potency, epileptiform and neurotoxic effects due to kainic acid.
Domenici
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MR
Laboratorio di Farmacologia, Istituto Superiore di Sanità Viale Regina Elena, Roma, Italy.
Longo
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Sagratella
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D000818:Animals; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007736:Kynurenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate
D018690:Excitatory Amino Acid Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D007736:Kynurenic Acid; C057013:7-chlorokynurenic acid; D007608:Kainic Acid