Interleukin-8 gene expression in Staphylococcus aureus-infected endothelial cells.
Interleukin-8 (IL-8) plays a crucial role in the migration of neutrophils to bacterium-infected sites. This study investigated IL-8 induction in Staphylococcus aureus-infected endothelial cells (EC). We observed that S. aureus-infected EC were induced to express both IL-8 mRNA and protein, which can promote transmigration of neutrophils across an EC monolayer.
Yao
L
L
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 104611, USA.
Lowy
F D
FD
Berman
J W
JW
D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D015870:Gene Expression; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000235:genetics; D009504:Neutrophils / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D013211:Staphylococcus aureus / Q000254:growth & development*
D016209:Interleukin-8; D012333:RNA, Messenger