Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturna.
Desmopressin (DDAVP) is frequently used in the treatment of primary isolated enuresis nocturna if other approaches have failed. We report a further case of hyponatraemia and cerebral convulsion due to water intoxication after intranasal DDAVP application by a 6 year-old boy with enuresis.


CONCLUSIONS
Although adverse reactions in DDAVP (e.g. hyponatraemia) are rare, it should not be considered as the first choice treatment of enuresis nocturna and only be used with caution.
Schwab
M
M
Universitätskinderklinik, Erlangen, Germany.
Wenzel
D
D
Ruder
H
H
D002648:Child; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D004200:Diseases in Twins; D004775:Enuresis / Q000188:drug therapy*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D012076:Renal Agents / Q000009:adverse effects*; D012640:Seizures / Q000209:etiology; D014869:Water Intoxication / Q000139:chemically induced* / Q000150:complications
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin