title: [A new class of small RNP (alpha-RNP) containing antisense RNA in K-562 cells. I. Their characteristics and changes during erythroid differentiation].
abstract: A new class of small RNP (alpha-RNP) has been detected and identified in nuclei and cytoplasm of A-562 erythroid leukemia cell line; these RNPs have a characteristic spectrum of proteins containing conservative and specific components and a special RNA component, which contains a small antisense component (alpha-RNA), a homolog of short dispersed Alu repeats. alpha-RNP is highly stable, tightly associated with chromatin in the nucleus, and is found in the free state in cytoplasm. The composition of nuclear and cytoplasmic alpha-RNP differ and have a specific pattern of changes in response to dimethylsulfoxide, an agent causing differentiation.
authors: I M
authors: IM
authors: Konstantinova
authors: O A
authors: OA
authors: Petukhova
authors: V A
authors: VA
authors: Kulikova
authors: L V
authors: LV
authors: Turoverova
authors: I V
authors: IV
authors: Volkova
authors: T N
authors: TN
authors: Ignatova
authors: I V
authors: IV
authors: Kozhukharova
authors: Iu B
authors: IuB
authors: Ermolaeva
authors: L N
authors: LN
authors: Gauze
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D002467:Cell Nucleus / Q000737:chemistry / Q000187:drug effects; D003593:Cytoplasm / Q000737:chemistry / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics; D016372:RNA, Antisense / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D012334:RNA, Neoplasm / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D017411:Ribonucleoproteins, Small Nuclear / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D016372:RNA, Antisense; D012334:RNA, Neoplasm; D017411:Ribonucleoproteins, Small Nuclear; D004121:Dimethyl Sulfoxide
vernacular_title: Novyĭ klass malykh RNP (al'fa-RNO), soderzhashchokh antismyslovuiu RNK, v kletkakh linii K-562. I. Kharakteristika i izmeneniia pri differentsirovke po éritroidnomu puti.