I/D polymorphism of the angiotensin-converting enzyme gene does not predict isolated systolic or systolic-diastolic hypertension in the elderly.
To determine whether insertion/deletion (I/D) polymorphism (intron 16) of the angiotensin converting-enzyme (ACE) gene is associated with isolated systolic hypertension (ISH: systolic blood pressure (BP) > or = 160, diastolic BP < 90 mm Hg) or systolic-diastolic hypertension (S-D hypertension: diastolic BP > or = 90 +/- systolic BP > or = 160 mm Hg) compared with normotensive controls (systolic BP < 160, diastolic BP < 90 mm Hg), we conducted a case-control study of 733 non-institutionalised, elderly (> or = 60 years) residents of Dubbo, NSW. Individuals were classified as: ISH (n = 167), S-D hypertension (n = 207) and normotensive control (n = 359) with age and sex matching. II, DD and ID genotypes were determined by a nested PCR strategy using DNA extracted from serum. The frequencies of D and I alleles in the control population (0.70 and 0.30 respectively) were not significantly different in the ISH group or the S-D hypertension group (chi 2: 1.7, P = 0.42). After adjustment for several potential confounders, neither genotype nor allele predicted ISH (II vs DD: odds ratio (OR): 1.06, 95% confidence interval (CI): 0.55-2.03; I vs D: 1.09, 0.82-1.46) or S-D hypertension (II vs DD: 1.19, 0.67-2.10; I vs D: 1.16, 0.89-1.52) in this elderly cohort. The I/D polymorphism of the ACE gene is not a marker for either form of hypertension in this large elderly sample.
Johnson
A G
AG
University Department of Medicine, Princess Alexandra Hospital, Brisbane, Australia.
Simons
L A
LA
Friedlander
Y
Y
Simons
J
J
Davis
D R
DR
MaCallum
J
J
D000368:Aged; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000235:genetics; D004251:DNA Transposable Elements; D003971:Diastole / Q000235:genetics*; D004198:Disease Susceptibility; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology*; D017384:Sequence Deletion; D013599:Systole / Q000235:genetics*
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A