[Reproductive and developmental toxicity studies of calcipotriol (MC903): (3)--A teratogenicity study in rabbits by subcutaneous administration].
Teratogenicity of calcipotriol (MC903), an anti-psoriasic agent, was studied. MC903 at doses of 0.1, 0.5, 1, 2.5 and 5 micrograms/kg/day was subcutaneously administered to pregnant Std:NZW rabbits from day 6 to 18 of gestation. 1. A decrease in locomotor activity was observed in the group administered MC903 5 micrograms/kg/day. Food consumption and body weight gain decreased dose-dependently in groups administered MC903 1 microgram/kg/day or more. Granular whitish kidneys were observed in groups administered MC903 2.5 and 5 micrograms/kg/day. Rough and whitish aorta were noted in groups administered MC903 1 microgram/kg/day or more. 2. Significant fetotoxicity was not induced by administration of MC903 up to 0.5 microgram/kg/day. 3. On the basis of results obtained in the present study, it is considered that no-toxic dose level of MC903 is 0.5 microgram/kg/day for pregnant animals and fetuses.
Uchiyama
H
H
Japan Seigiken Research Center Co., Ltd., Shizuoka, Japan.
Suzuki
T
T
Koike
Y
Y
Ono
M
M
Shirakawa
K
K
Nagata
M
M
Konishi
R
R
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D012098:Reproduction / Q000187:drug effects*; D015430:Weight Gain / Q000187:drug effects
D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol