title: Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.
abstract: We report that the many Eph-related receptor tyrosine kinases, and their numerous membrane-bound ligands, can each be grouped into only two major specificity subclasses. Receptors in a given subclass bind most members of a corresponding ligand subclass. The physiological relevance of these groupings is suggested by viewing the collective distributions of all members of a subclass. These composite distributions, in contrast with less informative patterns seen with individual members of the family, reveal that the developing embryo is subdivided into domains defined by reciprocal and apparently mutually exclusive expression of a receptor subclass and its corresponding ligands. Receptors seem to encounter their ligands only at the interface between these domains. This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan.
authors: Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York, 10591-6707, USA.
authors: Nicholas W
authors: NW
authors: Gale
authors: Sacha J
authors: SJ
authors: Holland
authors: David M
authors: DM
authors: Valenzuela
authors: Ann
authors: A
authors: Flenniken
authors: Li
authors: L
authors: Pan
authors: Terence E
authors: TE
authors: Ryan
authors: Mark
authors: M
authors: Henkemeyer
authors: Klaus
authors: K
authors: Strebhardt
authors: Hisamaru
authors: H
authors: Hirai
authors: David G
authors: DG
authors: Wilkinson
authors: Tony
authors: T
authors: Pawson
authors: Samuel
authors: S
authors: Davis
authors: George D
authors: GD
authors: Yancopoulos
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D004622:Embryo, Mammalian / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D006801:Humans; D008024:Ligands; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism* / Q000502:physiology; D014018:Tissue Distribution
chemical_list: D008024:Ligands; D020794:Receptor Protein-Tyrosine Kinases