title: Lack of effect of an acute ileal perfusion of short-chain fatty acids on glucose metabolism in healthy men.
abstract: Dietary fiber intake is associated with several beneficial effects on carbohydrate metabolism. Some authors have speculated that this improvement may be due to short-chain fatty acids (SCFA) produced by the colonic fermentation of dietary fibers. To test this hypothesis, six healthy men aged 26 +/- 2 (SE) yr with a body mass index of 20.9 +/- 0.7 received on three occasions an 18-h ileal perfusion infused at a flow rate of 3.3 ml/min, containing either 90 mmol/l of SCFA (60% acetate, 25% propionate, and 15% butyrate) (A), SCFA during the first 12 h and then a saline solution (A/S), or a saline solution (S). Basal hepatic glucose production (BHGP), insulin sensitivity (3-step euglycemic-hyperinsulinic clamp), and erythrocyte insulin binding (EIB) were studied 12 h after the beginning of the ileal perfusion. There was no change in BHGP or insulin sensitivity. However, maximal EIB was significantly different: 7.1 +/- 0.1 (A), 6.8 +/- 0.1 (A/S), vs. 6.5 +/- 0.1% (S) (P = 0.03). We conclude that acute administration of SCFA does not significantly alter glucose metabolism in healthy subjects.
authors: Laboratoire de Diabétologie, Institut National de la Santé et de la Recherche Médicale U 341, Paris, France.
authors: C
authors: C
authors: Alamowitch
authors: J
authors: J
authors: Boillot
authors: A
authors: A
authors: Boussairi
authors: A
authors: A
authors: Ruskone-Fourmestraux
authors: A
authors: A
authors: Chevalier
authors: S W
authors: SW
authors: Rizkalla
authors: F
authors: F
authors: Guyon
authors: F R
authors: FR
authors: Bornet
authors: G
authors: G
authors: Slama
mesh_terms: D000085:Acetates / Q000378:metabolism; D000328:Adult; D001769:Blood / Q000378:metabolism; D004032:Diet; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005232:Fatty Acids, Volatile / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D010477:Perfusion; D011972:Receptor, Insulin / Q000378:metabolism; D012016:Reference Values; D013997:Time Factors
chemical_list: D000085:Acetates; D005230:Fatty Acids, Nonesterified; D005232:Fatty Acids, Volatile; D011972:Receptor, Insulin; D005947:Glucose