title: A comparison of kainic acid plus colchicine and ibotenic acid-induced hippocampal formation damage on four configural tasks in rats.
abstract: J.W. Rudy and R.J. Sutherland (1989) suggested that the hippocampal formation (HF) is necessary for performance of configural tasks and that rats with kainic acid + colchicine (K-C) damage to the HF were impaired on the negative patterning problem (A+, B+, AB-). However, M. Gallagher and P.C. Holland (1992) found spared performance on a similar task (AC+, B+, AB-, C-) when ibotenic acid (IBO) was used. This study compared the effects of K-C- and IBO-induced HF damage on 4 configural tasks: (a) negative patterning, (b) the Gallagher-Holland task, (c) transverse patterning, and (d) place learning. Rats with IBO lesions performed like controls on the Gallagher-Holland task (replicating M. Gallagher & P.C. Holland) but were impaired on negative patterning, transverse patterning, and place learning. In contrast, rats with K-C lesions were impaired on all 4 tasks. The implications of these results for theories of HF function are discussed.
authors: Department of Psychology, University of Colorado, Boulder 80309, USA. alvarado@nba19.med.uth.tmc.edu
authors: M C
authors: MC
authors: Alvarado
authors: J W
authors: JW
authors: Rudy
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003078:Colchicine / Q000633:toxicity*; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007051:Ibotenic Acid / Q000633:toxicity*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D009949:Orientation / Q000187:drug effects* / Q000502:physiology; D011340:Problem Solving / Q000187:drug effects* / Q000502:physiology; D051381:Rats
chemical_list: D007051:Ibotenic Acid; D007608:Kainic Acid; D003078:Colchicine