title: Chondroid lipoma. A newly described lesion that may be mistaken for malignancy.
abstract: A case of chondroid lipoma located in the submandibular region of a 21-year-old man is presented. On macroscopic evaluation the tumor was lobulated and quite yellow. Microscopic examination showed that this tumor was composed of mature adipose tissue and eosinophilic cells. The eosinophilic cells displayed single or multiple vacuoles and resembled lipoblast or hibernoma-like cells. These were set in a myxoid or chondromyxoid stroma. Most cells reacted with antibodies directed against vimentin and neuron-specific enolase. Focal weak positivity for S-100 protein was noted. Principal considerations in the histopathologic differential diagnosis included hibernoma, myxoid liposarcoma, and extraskeletal myxoid chondrosarcoma (chordoid sarcoma).
authors: Department of Anatomical Pathology, Marques de Valdecilla University Hospital, Santander, Spain.
authors: J M
authors: JM
authors: Gomez-Ortega
authors: I G
authors: IG
authors: Rodilla
authors: J M
authors: JM
authors: Basco López de Lerma
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D003094:Collagen / Q000032:analysis; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000737:chemistry / Q000473:pathology*; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013365:Submandibular Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D003094:Collagen; D010751:Phosphopyruvate Hydratase