Decreased secretion of gonadotropins in a patient with Graves' disease.
A 56-year-old female with Graves' disease who presented with decreased secretion of gonadotropins is described. She was admitted to hospital because of her being in a state of confusion. One month before admission she had been diagnosed as having Graves' disease and was treated with methimazole since then. Plasma LH and FSH levels were undetectable, and their responses to LH-RH were extremely decreased in spite of undetectable levels of plasma estradiol and estriol. One year after treatment, both basal and stimulated values of LH and FSH reverted to normal as did those of TSH. Reversible suppression of gonadotropins as described herein has never been reported in cases of Graves' disease.
Hakamata
M
M
Department of Internal Medicine, Enshu General Hospital, Hamamatsu, Japan.
Itoh
M
M
Sudo
Y
Y
Katada
E
E
Miyata
N
N
D013956:Antithyroid Agents / Q000627:therapeutic use; D001835:Body Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000378:metabolism; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone; D006111:Graves Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
D013956:Antithyroid Agents; D014284:Triiodothyronine; D007987:Gonadotropin-Releasing Hormone; D008713:Methimazole; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine