Cryptococcal meningitis in a child with hyperimmunoglobulin E syndrome.
A 13-year-old boy with hyperimmunoglobulin E (hyper-IgE) syndrome presented with headache, blurred vision, photophobia and bilateral papilledema due to cryptococcal meningitis. Treatment with amphotericin B, and S-fluorocytosine for several weeks and repeated lumbar punctures did not reduce the intracranial pressure, and a myeloperitoneal shunt was performed. The child was maintained on fluconazole for an additional six months. Patients with hyper-IgE syndrome are at increased risk of opportunistic fungal infections such as cryptococcal meningitis.
Garty
B Z
BZ
Kipper Institute of Pediatric Allergy and Immunology, Department of Pediatrics, Petah Tiqva, Israel.
Wolach
B
B
Ashkenazi
S
S
Weismart
Y
Y
Rachmel
A
A
Nitzan
M
M
D000293:Adolescent; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007589:Job Syndrome / Q000150:complications / Q000276:immunology*; D016919:Meningitis, Cryptococcal / Q000209:etiology / Q000276:immunology*
D007073:Immunoglobulin E