title: A mild Theileria parva parasite with potential for immunisation against East Coast fever.
abstract: Twenty-three Friesian cattle were inoculated subcutaneously anterior to the left prescapular lymph node with 1 ml of a mild isolate of Theileria parva. The cattle developed low macroschizont parasitosis but no clinical reaction was observed. Thirty-five days later the cattle were grouped into five groups and challenged with five different Theileria parva isolates (four cattle-derived Theileria and one buffalo-derived Theileria). The cattle were all solidly immune to challenge with the cattle-derived Theileria isolates but three out of five of the cattle challenged with the buffalo-derived parasite died of theileriosis. All ten non-immunised control cattle developed severe theileriosis and were treated with buparvaquone (Butalex; Pitman-Moore).
authors: Kenya Agricultural Research Institute, National Veterinary Research Centre, Kikuyu.
authors: S K
authors: SK
authors: Mbogo
authors: D P
authors: DP
authors: Kariuki
authors: P N
authors: PN
authors: Ngumi
authors: N
authors: N
authors: McHardy
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002417:Cattle; D007114:Immunization; D009285:Naphthoquinones / Q000627:therapeutic use; D016052:Protozoan Vaccines; D016797:Theileria parva / Q000276:immunology / Q000302:isolation & purification; D013801:Theileriasis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones; D016052:Protozoan Vaccines; C046326:buparvaquone