[Clinical and psychological factors influencing the efficacy of botulinum toxin in the treatment of hemifacial spasm and blepharospasm].
We analyzed the influence of clinical and psychological factors on the long-term efficacy of botulinum toxin A (BTX) injections in 45 patients with blepharospasm and 66 patients with hemifacial spasm. Injections efficacy (respectively 94.3% and 95.7%) and duration of relief (respectively 14.8 and 18.7 weeks) remained stable over seven successive injections. Clinical improvement was not influenced by patients' sex, age, or disease duration but by psychological background (p < 0.001). Patients who failed to respond after repetitive injections had lower inter-injections intervals (p < 0.05). This data shows: (1) the importance of psychological contexte in subjective evaluation of treatment efficacy with BTX, (2) emphasizes the necessity of avoiding close injections.
Burbaud
P
P
Service d'Explorations Fonctionnelles du Système Nerveux, Hôpital du Haut-Lévèque, Pessac.
Arnaud
A
A
Burbaud
A
A
Lagueny
A
A
D000328:Adult; D000368:Aged; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy; D001764:Blepharospasm / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D001905:Botulinum Toxins / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy; D005152:Facial Muscles; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013035:Spasm / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D013997:Time Factors
D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins
Facteurs cliniques et psychologiques influençant l'efficacité de la toxine botulique dans le traitement de l'hémispasme facial et du blépharospasme.