Isochromosome 7q and trisomy 8 are consistent primary, non-random chromosomal abnormalities associated with hepatosplenic T gamma/delta lymphoma.
Four patients with hepatosplenic T gamma/delta lymphoma, a rare but distinct entity of peripheral T cell lymphoma, are reported on. In each case, cytogenetic studies showed the presence of an Isochromosome 7q and a trisomy 8. A few chromosome studies have previously been reported in this lymphoma subtype but comparison with these published cases confirms that isochromosome 7q and trisomy 8 are primary, non-random chromosomal abnormalities in hepatosplenic T gamma/delta lymphoma.
Jonveaux
P
P
Laboratoire de Génétique, CHU Nancy, Vandoeuvre, France.
Daniel
M T
MT
Martel
V
V
Maarek
O
O
Berger
R
R
D000293:Adolescent; D000328:Adult; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016130:Immunophenotyping; D018404:Isochromosomes; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics*; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013160:Splenic Neoplasms / Q000235:genetics*; D014314:Trisomy
D016692:Receptors, Antigen, T-Cell, gamma-delta