title: Spatial and non-spatial learning in the rat following lesions to the nucleus locus coeruleus.
abstract: The present experiment examined the effects of unilateral or bilateral locus coeruleus lesions on general activity, acquisition of a non-monotonic serial pattern (14-0-3-7 food pellets, respectively), and response learning acquisition in a Greek cross version of the Morris water maze. Sham-operated control rats were capable of tracking the elements of the serial pattern while rats with a unilateral locus coeruleus lesion were moderately impaired, and those with bilateral locus coeruleus lesions were severely impaired. A similar pattern of working memory deficits emerged in an analysis of the response-learning data in the Greek cross. The results are discussed in terms of the current understanding of norepinephrine and the locus coeruleus in learning and memory processes.
authors: Department of Psychology, Georgia College, Milledgeville 31061, USA.
authors: D M
authors: DM
authors: Compton
authors: K L
authors: KL
authors: Dietrich
authors: J S
authors: JS
authors: Smith
authors: B K
authors: BK
authors: Davis
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology; D051381:Rats; D012054:Reinforcement, Psychology