title: Lipoprotein lipase activity of post-heparin plasma in Japanese black cattle affected with fat necrosis.
abstract: Post-heparin plasma (PHP) lipoprotein lipase (LPL) activity and serum lipoprotein concentration were examined in Japanese Black cows affected with fat necrosis. The PHP-LPL activity in the affected cows was significantly (P < 0.001) higher than in normal animals and tended to reduce 4 weeks after treatment with isoprothiolane. This finding indicates that affected cows have a predisposition to deposit more fat into adipose tissue than normal animals. The serum concentrations of triglyceride in beta-lipoprotein and of cholesterol, phospholipid and total lipid in alpha-lipoprotein were significantly (P < 0.05) lower in the affected cows. Elevated levels of phospholipid and total lipid in alpha-lipoprotein as well as decreased levels of non-esterified fatty acid (NEFA) were observed after medication. It is suggested that isoprothiolane produces an improvement in hepatic lipid metabolism including acceleration of plasma NEFA uptake and alpha-lipoprotein secretion in affected cows.
authors: Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan.
authors: H
authors: H
authors: Katamoto
authors: M
authors: M
authors: Aoki
authors: Y
authors: Y
authors: Shimada
authors: E
authors: E
authors: Hakogi
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000201:enzymology*; D005218:Fat Necrosis / Q000097:blood / Q000201:enzymology / Q000662:veterinary*; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D007564:Japan; D008071:Lipoprotein Lipase / Q000097:blood*
chemical_list: D000925:Anticoagulants; D006493:Heparin; D008071:Lipoprotein Lipase