Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures.
There is accumulating evidence that cells exposed to low and often environmentally relevant doses of ionizing radiation survive the initial insult, but transmit genomic instability to their progeny. The underlying mechanism of radiation-induced genomic instability is unknown. We present bio-chemical evidence consistent with the hypothesis that enhanced and persistent oxy-radical activity may be responsible.
Clutton
S M
SM
Department of Experimental Haematology, MRC Radiation and Genome Stability Unit, Harwell, Oxon.
Townsend
K M
KM
Walker
C
C
Ansell
J D
JD
Wright
E G
EG
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D009154:Mutation; D018384:Oxidative Stress
D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine