title: In vitro cytotoxicity and immunomodulating property of Rhaphidophora korthalsii.
abstract: An in vitro cytotoxic screening of extracts of Rhaphidophora korthalsii indicated cytotoxicity in the ether fraction. ED50 values of the extract against P388, Molt 4, KB and SW 620 were 12, 14, 8 and 13 micrograms/ml, respectively. The extract was relatively more toxic on P388 and Molt 4 cell lines at concentrations of 50 micrograms/ml and 100 micrograms/ml. Screening with mouse splenocytes showed that the hot water extract had splenocytes stimulating activity.
authors: Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore.
authors: K T
authors: KT
authors: Wong
authors: B K
authors: BK
authors: Tan
mesh_terms: D000230:Adenocarcinoma; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms; D004396:Coloring Agents / Q000737:chemistry; D003208:Concanavalin A / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007938:Leukemia; D007941:Leukemia P388; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009303:Nasopharyngeal Neoplasms; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D037121:Plant Lectins; D010946:Plants, Medicinal; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013778:Tetrazolium Salts / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry; D014407:Tumor Cells, Cultured; D014867:Water / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D010936:Plant Extracts; D037121:Plant Lectins; D013778:Tetrazolium Salts; D013844:Thiazoles; D014867:Water; D003208:Concanavalin A; C022616:thiazolyl blue