title: Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.
abstract: The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded-DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.
authors: Department of Biochemistry and Biophysics, Texas A&M University, Texas Medical Center, Houston 77030-3303, USA.
authors: W A
authors: WA
authors: Rosche
authors: A
authors: A
authors: Jaworski
authors: S
authors: S
authors: Kang
authors: S F
authors: SF
authors: Kramer
authors: J E
authors: JE
authors: Larson
authors: D P
authors: DP
authors: Geidroc
authors: R D
authors: RD
authors: Wells
authors: R R
authors: RR
authors: Sinden
mesh_terms: D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009223:Myotonic Dystrophy / Q000235:genetics; D010957:Plasmids; D017384:Sequence Deletion; D018911:Trinucleotide Repeats
chemical_list: D004268:DNA-Binding Proteins