AIDS-like disease following mucosal infection of pig-tailed macaques with SIVsmmPBj14.
Following exposure of the rectal or vaginal mucosa to cell-free SIVsmmPBj14, four male and two female pig-tailed macaques developed a characteristic acute disease, including mucoid diarrhea, lymphopenia, and anorexia. Two macaques infected by the rectal route died within 14 days, and one female died of an AIDS-like disease at five months after inoculation. The three other animals have survived more than nine months, but all are exhibiting lymphadenopathy, thrombocytopenia, and progressive declines in percentages and numbers of CD4+ lymphocytes.
Fultz
P N
PN
Department of Microbiology, University of Alabama at Birmingham, 35294-2170,
Schwiebert
R
R
Stallworth
J
J
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D008254:Macaca nemestrina / Q000821:virology*; D008297:Male; D009092:Mucous Membrane / Q000821:virology; D012007:Rectum / Q000821:virology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D013997:Time Factors; D014621:Vagina / Q000821:virology*
D000914:Antibodies, Viral