Effect of shi-ka-ron on cytokine production of lymphocytes in mice treated with cyclophosphamide.
The effect of Shi-ka-ron (CX) on cytokine production of lymphocytes in mice treated with cyclophosphamide was investigated. Shi-ka-ron, a traditional Chinese prescription, consists of 8 crude Chinese herbal extracts. Its main efficacy is to strengthen the body resistance. We observed that each CX component stimulated interleukine-2 and interferon-gamma production of murine splenic lymphocytes both in vitro and in vivo. IL-2 and IFN-gamma production of splenic lymphocytes were also examined in mice treated with CX combined with cyclophosphamide (CY) in vivo. We found that CX not only could increase IL-2 and IFN-gamma production in vitro, but also in vivo at suboptimal concentration.
Jin
R
R
Department of Medical Technology, College of Medical Care and Technology, Gunma University, Japan.
Kurashige
S
S
D000818:Animals; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007376:Interleukin-2 / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects*; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR
D016207:Cytokines; D007376:Interleukin-2; D003520:Cyclophosphamide