Immunodeficiency and elevated CD4 T lymphocyte counts in two patients coinfected with human immunodeficiency virus and human lymphotropic virus type I.
We describe two patients who were coinfected with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV) type I. They had clinical evidence of immunodeficiency (anergy, oral candidiasis, and disseminated herpes zoster) despite having elevated CD4 T lymphocyte counts (range, 2,450-5,292/mm3). We conclude that CD4 lymphocyte counts may not be reliable markers of immunologic competence in patients coinfected with HIV and HTLV-I.
Fantry
L
L
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3923, USA.
De Jonge
E
E
Auwaerter
P G
PG
Lederman
H M
HM
D000328:Adult; D018791:CD4 Lymphocyte Count; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D008297:Male