Effect of motilin on the L-leucine transport in rabbit jejunum.
Motilin is a gastrointestinal peptide that stimulates the gastrointestinal motility in several species. The aim of the present work has been to determine the effect of motilin on the L-leucine absorption in rabbit jejunum. The results show that motilin inhibits the L-leucine Na(+)-dependent system of transport located in the mucosal border mainly by diminishing the apparent Vmax. Motilin did not directly affect the Na(+)-dependent system of transport, but it seems to act across the protein kinase C (PKC). These results suggest that motilin may act as a regulatory hormone of the intestinal absorption of nutrients.
Marco
R
R
Department of Fisiología, Facultad de Veterinaria, Universidad de Zaragoza, Spain.
Navarro
H
H
Rodriguez-Yoldi
M J
MJ
Sorribas
V
V
Alcalde
A I
AI
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism*; D008297:Male; D009037:Motilin / Q000494:pharmacology* / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
D009037:Motilin; D012964:Sodium; D011493:Protein Kinase C; D007930:Leucine