[Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury].
Platelet activating factor (PAF) and PAF receptor antagonist BN52021 were respectively administered by intrathecal or intravenous injection in cats. We observed their effects on blood flow and TXB2/ 6-keto-PGF1 alpha ratio (T/K ratio) in injured spinal cord and its adjacent region (L2-L4)s after trauma. The results showed that gray matter and white matter blood flow at L2-L4 segment significantly decreased T/K ratio elevated evidently in PAF group as compared with simple spinal cord injury, while gray matter and white matter blood flow at L2-L4 segment significantly increased and T/K ratio markedly decreased in BN52021 group as compared with simple spinal cord injury group. The results demonstrate and that PAF is an important factor leading to spinal cord blood flow reduction after trauma, and that PAF receptor antagonist BN52021 can evidently improve spinal cord blood flow and relieve secondary damage after trauma.
Xiao
J
J
Department of Orthopaedics, Shanghai Changzheng Hospital.
Zao
D
D
Zhen
H
H
D000818:Animals; D002415:Cats; D004224:Diterpenes; D005260:Female; D046934:Ginkgolides; D007278:Injections, Spinal; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011460:Prostaglandins F / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply*; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000503:physiopathology*; D013929:Thromboxane B2 / Q000097:blood
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D011460:Prostaglandins F; D013929:Thromboxane B2; C045856:ginkgolide B