[Periodic breathing during sleep at high altitudes in patients with bronchial asthma].
Earlier we found that asthmatic patients treated at a high altitude sanatorium (3.200 m) had numerous episodes of arterial blood desaturation during the night. To investigate if periodic breathing (PB) was responsible for those episode we studied 5 asthmatics (A) (mean age 34 yrs) and 3 healthy controls (C) (mean age 28 yrs) using MESAM 4, a simple, portable system recording breathing sounds, heart frequency, arterial blood saturation and body position. A and C subjects were first investigated at low altitude (760 m). There was no PB at 760 m in either group. At high altitude MESAM 4 recordings were performed on the 2nd and the 7th night after the ascent. On the 2nd night in the A group subjects the number of PB cycles averaged 37.2 (22-54) occupying 3.2% (2-5%) of estimated sleep time. The number of no-PB episodes was 52.4 (23-109). In the C group subjects the number of PB cycles was 83.6 (10-147) occupying 9% (1-14%) of estimated sleep time. The number of no-PB episodes averaged 45.6 (6-84). On the 7th night in A the number of PB cycles was 46.6 (15-69) occupying 4% (1-7%) of estimated sleep time. The number of no-PB was 54.8 (13-147). In C the number of PB cycles averaged 29.3 (12-59) occupying 3.3% (2-6%) of estimated sleep time. The number of no-PB was 20.3 (9-37). We conclude that majority of desaturations during sleep in asthmatics at altitude of 3.200 m was not related to PB; the mechanisms of these desaturations require more investigations.
Koziej
M
M
Kliniki Chorób Płuc Instytutu Gruźlicy i Chorób Płuc w Warszawie.
Brimkulov
N N
NN
Koychumanov
B K
BK
Mirbakieva
D M
DM
Mirrakhimov
M M
MM
Zieliński
J
J
D000328:Adult; D000531:Altitude; D001249:Asthma / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010507:Periodicity; D012119:Respiration / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D013147:Spirometry
D010100:Oxygen
Oddychanie okresowe w czasie snu w wysokich górach u chorych na astme oskrzelowa.