[Increase of alpha-fetoprotein in pancreatic endocrine tumors with hepatic metastases. Apropos of 2 cases].
We report two cases of metastatic non-functioning pancreatic endocrine tumour with very elevated plasma levels of alpha-fetoprotein. In these two cases, serial plasma levels of alpha-fetoprotein, initially normal, correlated well with hepatic tumour progression and were associated with fatal outcome. These results suggest that elevated plasma concentration of alpha-fetoprotein may be caused by metastatic pancreatic endocrine tumour and than alpha-fetoprotein serial measurement may be useful in prognostic evaluation.
Lesur
G
G
Service d'Hépato-Gastroentérologie, Hôpital Ambroise-Paré, Boulogne.
Bergemer
A M
AM
Turner
L
L
Parlier
H
H
Bernades
P
P
Dupuy
P
P
D000970:Antineoplastic Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D000509:alpha-Fetoproteins / Q000032:analysis*
D000970:Antineoplastic Agents; D000509:alpha-Fetoproteins
Elévation de l'alpha-foetoprotéine au cours des tumeurs endocrines pancréatiques avec métastases hépatiques. Présentation de deux cas.