HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis.
The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal control (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p < 0.0004, pc < 0.0012; RR = 5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.
Quadri
S A
SA
Department of Pathology, McMaster University Medical Center, Hamilton, Ontario, Canada.
Taneja
V
V
Mehra
N K
NK
Singal
D P
DP
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D001208:Asia / Q000208:ethnology; D001483:Base Sequence; D005060:Europe / Q000208:ethnology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015804:HLA-DR4 Antigen / Q000032:analysis; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D044465:White People
D015804:HLA-DR4 Antigen; D018840:HSP70 Heat-Shock Proteins; D015335:Molecular Probes