Potential criteria for cohort selection in chemoprevention trials of uterine adenocarcinoma.
Women at risk of uterine cancer include those with one or more of the following characteristics: obesity, nulliparity, late menopause, diabetes mellitus, prolonged unopposed estrogen use, and tamoxifen therapy. Risk is additionally increased by the presence of endometrial hyperplasia. The incorporation of biomarkers into the selection criteria of cohort groups at risk for developing endometrial cancer offers an innovative approach to the clinical design of chemoprevention trials of endometrial adenocarcinoma. Biomarkers that may be useful in cohort selection include nuclear morphometry, specific genetic abnormalities, and markers of proliferation and differentiation.
Baker
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Division of Gynecologic Oncology, University of Texas-Houston Health Science Center, Houston 77030, USA.
D000230:Adenocarcinoma / Q000737:chemistry / Q000517:prevention & control*; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D018579:Patient Selection; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000737:chemistry / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D014408:Biomarkers, Tumor