title: Permeability function related to cerebral microvessel enzymes during ageing in rats.
abstract: Cerebral microvessels from rats were prepared and characterized by their enrichment of specific markers, namely alkaline phosphatase (AP) and tau-glutamyl transpeptidase (tau-GT). Further, it was observed that AP and tau-GT registered marked increase in aged rats. On the contrary, lactate dehydrogenase (LDH) activity decreased with the increasing age. Monoamine oxidase A activity in the microvessels decreased with age whereas MAO-B moved in the reverse direction. No noticeable change was seen in acetyl-cholinesterase activity with increasing age of rats.
authors: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors: A
authors: A
authors: Agrawal
authors: R
authors: R
authors: Shukla
authors: L M
authors: LM
authors: Tripathi
authors: V C
authors: VC
authors: Pandey
authors: R C
authors: RC
authors: Srimal
mesh_terms: D000110:Acetylcholinesterase / Q000502:physiology; D000375:Aging / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D002196:Capillaries / Q000201:enzymology*; D002199:Capillary Permeability / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D007770:L-Lactate Dehydrogenase / Q000502:physiology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D007770:L-Lactate Dehydrogenase; D008995:Monoamine Oxidase; D005723:gamma-Glutamyltransferase; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase