title: Caudate, putamen, and globus pallidus volume in schizophrenia: a quantitative MRI study.
abstract: Basal ganglia structures have been reported to be abnormal in schizophrenia. However, while component structures of the basal ganglia are functionally differentiated, there have been no evaluations of their separate magnetic resonance imaging (MRI) volumes with small voxel (1.5 mm3) spoiled gradient-recalled acquisition in steady state techniques and multi-plane assessments. We examined MRI scans from 15 male, right-handed, neuroleptic-medicated schizophrenic patients and 15 age-, handedness-, and gender-matched normal volunteers. Compared with normal subjects, schizophrenic patients showed enlarged volumes: 14.2% for total basal ganglia, 27.4% for globus pallidus, 15.9% for putamen, and 9.5% for caudate. Increased volumes, especially of the caudate, were associated with poorer neuropsychological test performance on finger tapping and Hebb's Recurring Digits. These findings indicate abnormalities throughout all basal ganglia structures in at least a subgroup of schizophrenic patients.
authors: Harvard Medical School Department of Psychiatry, Brockton/West Roxbury Veterans Affairs Medical Center, Boston, MA, USA.
authors: H
authors: H
authors: Hokama
authors: M E
authors: ME
authors: Shenton
authors: P G
authors: PG
authors: Nestor
authors: R
authors: R
authors: Kikinis
authors: J J
authors: JJ
authors: Levitt
authors: D
authors: D
authors: Metcalf
authors: C G
authors: CG
authors: Wible
authors: B F
authors: BF
authors: O'Donnell
authors: F A
authors: FA
authors: Jolesz
authors: R W
authors: RW
authors: McCarley
mesh_terms: D000328:Adult; D002421:Caudate Nucleus / Q000473:pathology*; D004292:Dominance, Cerebral / Q000502:physiology; D005917:Globus Pallidus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D009483:Neuropsychological Tests; D011699:Putamen / Q000473:pathology*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology; D012565:Schizophrenic Psychology