Pituitary macroadenoma in Addison's disease.
Long-standing primary failure of pituitary-dependent endocrine glands may lead to hyperplasia of the pituitary cells. These changes in the pituitary gland may be correlated with the severity and duration of target-endocrine gland insufficiency. Production of adrenocorticotrophic hormone by the pituitary tumour and modest hyperprolactinaemia may develop due to adrenocortical insufficiency, but production of prolactin by the pituitary tumour due to primary adrenal insufficiency is rare. A case study is presented, with primary adrenal insufficiency associated with hyperprolactinaemia and pituitary macroadenoma (most probably prolactinoma). Plasma levels of prolactin were found to decrease after glucocorticoid, mineralocorticoid and bromocriptine therapy.
Akçay
G
G
Department of Internal Medicine, School of Medicine, Instanbul University, Turkey.
Aral
F
F
Ozbey
N
N
Azezli
A
A
Orhan
Y
Y
Sencer
E
E
Molvalilar
S
S
D000224:Addison Disease / Q000097:blood / Q000150:complications*; D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D000324:Adrenocorticotropic Hormone / Q000097:blood; D001971:Bromocriptine / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood; D006727:Hormone Antagonists; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D008901:Mineralocorticoids / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood; D011859:Radiography; D013739:Testosterone / Q000097:blood
D006727:Hormone Antagonists; D008901:Mineralocorticoids; D001971:Bromocriptine; D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011239:Prednisolone; D005438:Fludrocortisone; D006854:Hydrocortisone