title: Adrenal adenomas: relationship between histologic lipid and CT and MR findings.
abstract: OBJECTIVE
  To assess the relationship between the quantity of lipid in resected adrenal adenomas and the unenhanced computed tomographic (CT) attenuation number and the relative change in signal intensity on chemical shift magnetic resonance (MR) images.
  
  
  METHODS
  The percentage of lipid-rich cortical cells in histologic sections from 20 resected adrenal adenomas was assessed. The results were correlated with the corresponding unenhanced CT attenuation number or the relative change in signal intensity on chemical shift MR images, or both.
  
  
  RESULTS
  There was an inverse linear relationship between the percentage of lipid-rich cortical cells in the adrenal adenomas and the unenhanced CT attenuation number (R2 = .68, P = .0005). There was a similar inverse linear relationship to the relative change in MR signal intensity on chemical shift images by using both quantitative (R2 = .83, P = .004) and qualitative (R2 = .70, P = .019) assessment.
  
  
  CONCLUSIONS
  The presence and amount of histologic lipid in many adrenal adenomas accounts for their low attenuation on unenhanced CT scans and their loss in relative signal intensity on chemical shift MR images.
authors: Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109-0030, USA.
authors: M
authors: M
authors: Korobkin
authors: T J
authors: TJ
authors: Giordano
authors: F J
authors: FJ
authors: Brodeur
authors: I R
authors: IR
authors: Francis
authors: E S
authors: ES
authors: Siegelman
authors: L E
authors: LE
authors: Quint
authors: N R
authors: NR
authors: Dunnick
authors: J P
authors: JP
authors: Heiken
authors: H H
authors: HH
authors: Wang
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D000311:Adrenal Glands / Q000000981:diagnostic imaging* / Q000378:metabolism; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data