title: Effect of food on the bioavailability of oxybutynin from a controlled release tablet.
abstract: OBJECTIVE
  The effect of food on the bioavailability of oxybutynin was assessed in a randomised cross-over study in 23 healthy volunteers. A single oral 10 mg dose of a controlled release oxybutynin tablet was administered after a high fat breakfast and to fasting subjects. The AUC, Cmax, tmax, t1/2 and MRT of oxybutynin and its active metabolite N-desethyloxybutynin were determined.
  
  
  RESULTS
  Breakfast did not change the AUC of oxybutynin but increased the AUC of N-desethyloxybutynin by about 20%. The Cmax of oxybutynin and N-desethyloxybutynin were two-fold higher when the drug was administered after breakfast compared to the fasting state.
  
  
  CONCLUSIONS
  Breakfast significantly reduced the MRT of oxybutynin and N-desethyloxybutynin.
authors: Leiras Oy, Helsinki, Finland.
authors: E
authors: E
authors: Lukkari
authors: P
authors: P
authors: Castrèn-Kortekangas
authors: A
authors: A
authors: Juhakoski
authors: E
authors: E
authors: Löyttyniemi
authors: K
authors: K
authors: Aranko
authors: P J
authors: PJ
authors: Neuvonen
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D018680:Cholinergic Antagonists / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D005260:Female; D005502:Food; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000493:pharmacokinetics*
chemical_list: D018680:Cholinergic Antagonists; D003692:Delayed-Action Preparations; D008333:Mandelic Acids; C005419:oxybutynin