The GB hepatitis viruses.
The genomes of three new flavi-like viruses, GBV-A, GBV-B and GBV-C have been identified. Nucleic acid molecules corresponding to the genomes of GBV-A and GBV-B were isolated from tamarins with hepatitis which had been infected with the GB agent. RNA sequences corresponding to GBV-C have been shown to be present in sera from humans with non-A-E hepatitis. Sequence comparisons show that these three viruses are more closely related to each other and to hepatitis C virus (HCV) than to any other known viruses. Together with HCV they appear to form a discrete cluster of related viruses within the larger genus of flaviviridae. The pathological significance of these viruses and their association with hepatitis is currently emerging.
Karayiannis
P
P
Department of Medicine, Imperial College School of Medicine at St Mary's, London, UK.
McGarvey
M J
MJ
D000818:Animals; D018067:Flaviviridae / Q000145:classification* / Q000235:genetics / Q000276:immunology; D016679:Genome, Viral; D016174:Hepacivirus / Q000145:classification / Q000235:genetics; D006524:Hepatitis, Viral, Animal / Q000235:genetics / Q000635:transmission / Q000821:virology*; D006525:Hepatitis, Viral, Human / Q000235:genetics / Q000276:immunology / Q000635:transmission; D006801:Humans; D008992:Monkey Diseases / Q000821:virology*; D012367:RNA, Viral / Q000302:isolation & purification; D012452:Saguinus
D012367:RNA, Viral