title: Induction of differentiation of embryonal carcinoma F9 cells by iron chelators.
abstract: The effects of several chelators, including hinokitiol, on embryonal carcinoma F9 cell differentiation were assessed by assaying the production of plasminogen activator (PA) as a differentiation marker protein. Hinokitiol and tropolone which were potent differentiation inducers lost their activity following preincubation with Fe2+ and Fe3+ ions. Other metal ions had no or little effect on the hinokitiol-induced differentiation. Of several chelators examined, dithizone induced differentiation as effectively as did hinokitiol and tropolone. Dithizone-induced differentiation was also inhibited by preincubation with Fe3+ ions. It was concluded that some potent iron chelators could trigger the teratocarcinoma F9 cells to differentiate through the chelation with intracellular iron ions.
authors: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors: T
authors: T
authors: Tanaka
authors: N
authors: N
authors: Muto
authors: N
authors: N
authors: Itoh
authors: A
authors: A
authors: Dota
authors: Y
authors: Y
authors: Nishina
authors: A
authors: A
authors: Inada
authors: K
authors: K
authors: Tanaka
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D018236:Carcinoma, Embryonal / Q000473:pathology*; D002412:Cations; D002454:Cell Differentiation / Q000187:drug effects; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007700:Kinetics; D008670:Metals / Q000494:pharmacology; D051379:Mice; D039821:Monoterpenes; D018243:Teratocarcinoma / Q000473:pathology; D014334:Tropolone / Q000031:analogs & derivatives / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D016588:Anticarcinogenic Agents; D002412:Cations; D007502:Iron Chelating Agents; D008670:Metals; D039821:Monoterpenes; D014334:Tropolone; C009479:beta-thujaplicin