[Apoptosis induced by myc family genes].
Recent studies have revealed that c-Myc is involved not only in cellular transformation but also in apoptosis induction. However, the intronless myc family genes such as s-myc, N-myc2, mycL2 lack transforming ability and retain only apoptosis inducing activity. Although much remains to be clear regarding the molecular mechanism of apoptosis induction by myc gene expression, our recent results suggest that the intronless myc genes significantly differ from that of the c-myc gene in their requirement for wild-type p53 activity in apoptosis induction. We introduce here recent reports on Myc-mediated apoptosis and discuss its molecular mechanism.
Kagaya
S
S
Biophysics Division, National Cancer Center Research Institute.
Kitanaka
C
C
Kuchino
Y
Y
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D016213:Cyclins; D016259:Genes, myc / Q000502:physiology; D006801:Humans; D009955:Ornithine Decarboxylase; D014157:Transcription Factors
D016213:Cyclins; D014157:Transcription Factors; D009955:Ornithine Decarboxylase