[Detection of placental alkaline phosphatase in ovarian cancer].
OBJECTIVE
To establish a method for diagnosis of malignant tumors by determination of the placental alkaline phosphatase (PLAP) in serum.


METHODS
A solid phase enzyme immunoassay was adopated by an antibody against PLAP. PLAP in serum of 81 patients with malignant tumor and 86 healthy people as control were determined.


RESULTS
In the control group, the PLAP activity showed deviative distribution, the 95th percentile values of PLAP in control group was 3.8U/L. If this value served as normal cut-off line, 18 cases among 81 patients with malignant tumors were positive. The positive rate was 22.2%, but the positive rates in ovarian cancer was 61.9%.


CONCLUSIONS
The increasing of serum PLAP may be helpful for the diagnosis of malignant tumors especially ovarian cancer.
Wang
R
R
Binzhou Medical College.
Song
L
L
Ding
L
L
D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000097:blood*; D010051:Ovarian Neoplasms / Q000201:enzymology*; D010920:Placenta / Q000201:enzymology
D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental