Inhibition of nitric oxide synthase or cyclo-oxygenase pathways in organum vasculosum laminae terminalis attenuates interleukin-1 beta fever in rabbits.
Fever was induced in rabbits by i.v. administration of lipopolysaccharide (LPS) or administration of interleukin-1 beta (IL-1 beta) into the organum vasculosum laminae terminalis (OVLT). Intra-OVLT injection of IL-1 receptor antagonist (IL-lra), 1 h before LPS or IL-1 beta injection, inhibited the LPS- or IL-1 beta-induced fever. Dexamethasone (a potent inhibitor of the transcription of inducible nitric oxide synthase, iNOS), L-N5-(1-iminoethyl)ornithine (an irreversible NOS inhibitor), aminoguanidine (a specific iNOS inhibitor), or indomethacin (an inhibitor of cyclo-oxygenase, COX) also inhibited IL-1 beta-induced fever when injected into the OVLT 1 h before IL-1 beta injection. These results suggest that iNOS or COX pathways in the OVLT mediate the IL-1 beta-induced fever in rabbits.
Lin
J H
JH
Department of Physiology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC.
Lin
M T
MT
D000818:Animals; D005334:Fever / Q000139:chemically induced*; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000187:drug effects*; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D007375:Interleukin-1; D008070:Lipopolysaccharides; D019001:Nitric Oxide Synthase; D011451:Prostaglandin-Endoperoxide Synthases