[The mechanism of action of sennosides].
A review of the recent progress in the study of the mode of action of the sennosides, the active constituents of the senna drug, is presented. An interaction between rhein anthrone, the active metabolite of the sennosides, and the immune cells of the colon is suggested as a base for laxative activity.
Lemli
J
J
Termeredellelaan 3, Winksele (Belgique).
D000818:Animals; D000873:Anthracenes / Q000378:metabolism / Q000494:pharmacology; D000880:Anthraquinones / Q000378:metabolism / Q000494:pharmacology*; D002400:Cathartics / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology; D007422:Intestines / Q000187:drug effects / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000187:drug effects; D012676:Senna Extract; D000081226:Sennosides; D000095322:Anthrones
D000873:Anthracenes; D000880:Anthraquinones; D002400:Cathartics; D012676:Senna Extract; D000081226:Sennosides; C055876:rhein-9-anthrone; D000095322:Anthrones
Mécanisme d'action des sennosides.