[The effect of furosemide and valium on band 3 protein anion transport function in chronic respiratory failure patients].
In order to explore the effect of drugs on band 3 protein anion transport function and its clinical significance, several common drugs such as furosemide, hydrochlorothiazide, etc, were tested. The results demonstrated that furosemide, hydrochlorothiazide and valium could inhibit rapidly and reversibly the anion transport function of band 3 protein and led to HCO-3/Cl- exchange restriction. The mechanism of action of the drugs was thought to be an interaction between drugs and the two sites of band 3 protein anion transport system. The reason that pulmonary encephalopathy was induced by diuretics and sedatives may be related to the inhibition of anion transport by the drugs and reduced CO2 elimination. It was necessary to be careful in using these drugs in patients with impaired lung function, especially the patients of cor pulmonale with type II respiratory failure.
Yang
X
X
Respiratory Centre, Xinqiao Hospital, Third Military Medical University, Chongqing.
Mao
B
B
Qian
G
G
D000368:Aged; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000378:metabolism*; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology
D001457:Anion Exchange Protein 1, Erythrocyte; D004232:Diuretics; D006993:Hypnotics and Sedatives; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D005665:Furosemide; D003975:Diazepam