title: Effects of pneumoperitoneum on splanchnic hemodynamics: an experimental study in pigs.
abstract: OBJECTIVE
  To study the effects on splanchnic haemodynamics of pneumoperitoneum induced by carbon dioxide insufflation.
  
  
  METHODS
  Controlled experimental study.
  
  
  METHODS
  11 Pigs weighing 19-30 kg.
  
  
  METHODS
  The animals were divided into a control group (n = 4) and a experimental group (n = 7). Experimental animals were subjected to stepwise increasing intra-abdominal pressure from 0 mm Hg to 25 mm Hg by carbon dioxide insufflation.
  
  
  METHODS
  Portal venous blood flow, portal venous blood pressure, portal/hepatic vascular resistance, and gastrointestinal vascular resistance.
  
  
  RESULTS
  At 25 mm Hg portal venous blood flow was reduced (66% of baseline), and portal venous blood pressure and portal/hepatic vascular resistance were increased (360% and 650% of baseline, respectively). The increase in gastrointestinal vascular resistance was less pronounced.
  
  
  CONCLUSIONS
  Increased intra-abdominal pressure caused significant changes in the splanchnic haemodynamics. The risk was greater if the intra-abdominal pressure exceeded 15 mm Hg.
authors: Department of Surgery, University Hospital, Uppsala, Sweden.
authors: I B
authors: IB
authors: Rasmussen
authors: U
authors: U
authors: Berggren
authors: D
authors: D
authors: Arvidsson
authors: M
authors: M
authors: Ljungdahl
authors: U
authors: U
authors: Haglund
mesh_terms: D000818:Animals; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011028:Pneumoperitoneum, Artificial; D011312:Pressure; D013152:Splanchnic Circulation / Q000502:physiology*; D013552:Swine