title: Comparative in-vitro activity of sparfloxacin against genital pathogens.
abstract: The in-vitro activity of sparfloxacin against four pathogens commonly implicated in genital infections was compared with that of a number of other commonly administered antimicrobials. Sparfloxacin demonstrated excellent activity against Neisseria gonorrhoeae (MIC range of < or = 0.0002-5 mg/L for beta-lactamase producing strains, and < or = 0.0002-0.03 mg/L for non-beta-lactamase producing strains). This activity was similar to that of lomefloxacin and ciprofloxacin and was greater than that of ofloxacin. Sparfloxacin was more active against Ureaplasma urealyticum (MIC90 1 mg/L) than the other three quinolones (MIC90 4 mg/L). Sparfloxacin was much more active against Mycoplasma hominis (MIC90 0.06 mg/L) than the other quinolones (MIC90 1 mg/L). Sparfloxacin showed the most potent inhibitory and bactericidal activity of the quinolones against Chlamydia trachomatis with MIC and MBC of 0.06 mg/L (ofloxacin MIC and MBC 1 mg/L; ciprofloxacin and lomefloxacin MIC and MBC 2 mg/L). The results of this study and others performed by workers using different methods are consistently similar. Since sparfloxacin has broad activity against pathogens implicated in genital infections it may be a good therapeutic alternative for these syndromes.
authors: Department of Microbiology, University of Seville, Spain.
authors: E J
authors: EJ
authors: Perea
authors: J
authors: J
authors: Aznar
authors: M C
authors: MC
authors: Garcia-Iglesias
authors: A
authors: A
authors: Pascual
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects*; D005260:Female; D024841:Fluoroquinolones; D005831:Genital Diseases, Female / Q000382:microbiology*; D005832:Genital Diseases, Male / Q000382:microbiology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects*; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*; D016990:Ureaplasma urealyticum / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C061363:sparfloxacin