title: Functional analysis of Drosophila developmental genes instrumental in tumor suppression.
abstract: Of the 28 presently known Drosophila tumor suppressor genes we present the status of the functional analysis of the following three genes: (a) lethal (3) malignant brain tumor [1(3)mbt], which by homology belongs to the Pc-G gene family and may be involved in the stable silencing of specific developmental genes by changing the chromatin structure, and thus establishing and maintaining the differentiated state; (b) lethal (3) malignant blood neoplasm-1 [1(3)mbn-1], for whose function only vague predictions can be made; 4) benign (2) gonial cell neoplasm [b(2)gcn], which may function as a splice factor. Each Drosophila tumor suppressor gene transforms in the homozygously mutated state either one or two specific cell-types in a single step, and is thus the primary cause for tumorigenesis. For one of the genes a putative human homologue has been found.
authors: Institut für Genetik, Johannes Gutenberg-Universität Mainz, Germany.
authors: E
authors: E
authors: Gateff
authors: J
authors: J
authors: Wismar
authors: N
authors: N
authors: Habtemichael
authors: T
authors: T
authors: Löffler
authors: S
authors: S
authors: Dreschers
authors: S
authors: S
authors: Kaiser
authors: U
authors: U
authors: Protin
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D016296:Mutagenesis; D009369:Neoplasms / Q000235:genetics; D014170:Transformation, Genetic / Q000235:genetics