title: Determination of cystic fibrosis carrier frequency for Zuni native Americans of New Mexico.
abstract: The Zuni native Americans of the Southwest have an incidence of cystic fibrosis of approximately one in 333 or seven and one-half times that found for Caucasians. Earlier studies indicated that dF508 was not among the cystic fibrosis mutations causing this disease. Through a collaborative study the R1162X mutation was found on 12 out of 12 cystic fibrosis chromosomes from six Zuni patients. Because of the relative high incidence of cystic fibrosis, we undertook a study to determine the carrier frequency of the R1162X mutation among randomly sampled individuals. We found the carrier frequency in the general population for the R1162X to be 6.7%, a very significant number when compared with the carrier frequency for all cystic fibrosis mutations in the Caucasian population of approximately 4%.
authors: Zuni PHS Hospital, New Mexico.
authors: D
authors: D
authors: Kessler
authors: C
authors: C
authors: Moehlenkamp
authors: G
authors: G
authors: Kaplan
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009516:New Mexico / Q000208:ethnology