Frequent occurrence of genetic reassortment between influenza C virus strains in nature.
Previous studies of the haemagglutinin-esterase (HE) genes of various influenza C isolates suggested the existence of three distinct virus lineages (C/Yamagata/26/81-, C/Aichi/1/81- and C/Mississippi/80-related lineages) in Japan in the 1980s. Here we analysed the genetic properties of three strains (C/Yamagata/5/92, C/Miyagi/3/93 and C/Miyagi/4/93) isolated in Yamagata and Sendai Cities, Japan, in 1992/1993. Comparison of total or partial nucleotide sequences of the seven RNA segments of C/Yamagata/5/92 with those of 11 previous isolates suggested that the 1992 strain is a reassortant which inherited HE, P3, NP and M genes from a C/Mississippi/80-like virus and PB2, PB1 and NS genes from a C/pig/Beijing/115/81-like virus. Furthermore, it became evident that at least two (C/England/83 and C/Yamagata/9/88) of the 11 reference strains are also reassortants.
Peng
G
G
Department of Bacteriology, Yamagata University School of Medicine, Japan.
Hongo
S
S
Kimura
H
H
Muraki
Y
Y
Sugawara
K
K
Kitame
F
F
Numazaki
Y
Y
Suzuki
H
H
Nakamura
K
K
D000818:Animals; D002642:Chick Embryo; D002648:Child; D016679:Genome, Viral; D006389:Hemagglutinins, Viral / Q000235:genetics; D006801:Humans; D007251:Influenza, Human / Q000821:virology; D009982:Gammainfluenzavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics* / Q000302:isolation & purification; D014760:Viral Fusion Proteins; D014764:Viral Proteins / Q000235:genetics
D006389:Hemagglutinins, Viral; D012367:RNA, Viral; D014760:Viral Fusion Proteins; D014764:Viral Proteins; C060814:hemagglutinin esterase