Unilateral vestibular deafferentation (UVD) causes permanent asymmetry in the gain of the yaw VOR to high acceleration head impulses in guinea pigs.
Using an acute scleral search coil technique for measuring eye position in alert animals we have shown that after UVD the yaw VOR in the guinea pig shows a permanent gain asymmetry. There is a reduced gain during the first 100 ms of brief, high acceleration horizontal head rotations ("yaw head impulses") towards the operated side, but only a small loss in gain for similar rotations towards the intact side. This result confirms that the horizontal E response during the first 100 ms of an abrupt high acceleration head rotation is a clear indicator of the function of the horizontal canal. These results are similar to those in human patients after unilateral acoustic neuroma operations. The asymmetry in response is large shortly after UVD and decreases over time but is permanent.
Curthoys
I S
IS
Department of Psychology, University of Sydney, NSW, Australia.
Topple
A N
AN
Halmagyi
G M
GM
D000054:Acceleration; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004292:Dominance, Cerebral / Q000502:physiology*; D006168:Guinea Pigs; D004856:Postural Balance / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D012665:Semicircular Canals / Q000294:innervation*; D014724:Vestibular Function Tests; D014725:Vestibular Nerve / Q000503:physiopathology*