Further studies on the lobar heterogeneity in response to coumarin-mediated hepatotoxicity.
A randomized sampling protocol coupled with quantitative morphometry has been used to evaluate the inter-lobe variation in centrilobular hepatic necrosis in the mouse, and periportal hepatic necrosis in the beta-naphthoflavone-induced rat, both in response to treatment with coumarin. The results of these studies indicate a random inter-lobe variation in xenobiotic-mediated hepatotoxicity.
Jack
K R
KR
Department of Human Morphology, University of Nottingham Medical School, UK.
Kho
K
K
Thomas
N W
NW
Fry
J R
JR
D000818:Animals; D001571:Benzoflavones; D001835:Body Weight / Q000187:drug effects; D003374:Coumarins / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051379:Mice; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013048:Specimen Handling / Q000379:methods; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D003374:Coumarins; D019324:beta-Naphthoflavone; C030123:coumarin