title: Chlamydia pneumoniae community-acquired pneumonia: a review of 62 hospitalized adult patients.
abstract: In a prospective study, Chlamydia pneumoniae was identified as the etiological agent in 62 (17.9%) of 346 adult patients hospitalized over the course of one year for community-acquired pneumonia at the Soroka Medical Center in Beer-Sheva, Israel. The diagnosis of C. pneumoniae infection was based on serological testing of antibodies by the MIF technique. In 43 of these patients (69.4%), at least one other etiological agent, in addition to C. pneumoniae for community-acquired pneumonia was identified. Streptococcus pneumoniae was identified in 34 patients with C. pneumoniae (54.8%), as an additional causative factor in infection. Community-acquired pneumonia patients with C. pneumoniae were significantly older than non-C. pneumoniae patients (p = 0.03), had a higher APACHE II score on admission (p < 0.05), a higher rate of positive blood cultures (p = 0.02), and longer periods of hospitalization (p = 0.022). Seven patients with pure C. pneumoniae infection recovered, despite treatment which is not considered to be specific for C. pneumoniae. It was concluded that C. pneumoniae is a common etiological agent for community-acquired pneumonia in our region, particularly in the elderly, and is characterized by a high rate of concomitant infections with other pulmonary pathogens. No specific clinical or radiological pattern was discerned that could distinguish between C. pneumoniae community-acquired pneumonia and non-C. pneumoniae community-acquired pneumonia.
authors: Div. of Internal Medicine, Soroka Medical Center of Kupat Holim, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors: D
authors: D
authors: Lieberman
authors: M
authors: M
authors: Ben-Yaakov
authors: Z
authors: Z
authors: Lazarovich
authors: A
authors: A
authors: Porath
authors: F
authors: F
authors: Schlaeffer
authors: D
authors: D
authors: Lieberman
authors: M
authors: M
authors: Leinonen
authors: P
authors: P
authors: Saikku
authors: O
authors: O
authors: Horovitz
authors: I
authors: I
authors: Boldur
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002690:Chlamydia Infections / Q000175:diagnosis*; D016993:Chlamydophila pneumoniae; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis; D011024:Pneumonia, Viral / Q000175:diagnosis; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents