Assessment of orocaecal transit time in cats by the breath hydrogen method: the effects of sedation and a comparison of definitions.
Oro-caecal transit times (OCTTs) were assessed in 10 healthy adult cats by the lactulose breath hydrogen method with either no sedation (group A), or after the intramuscular administration of three sedative regimens: a combination of acetylpromazine at 0.1 mg kg-1 with buprenorphine at 10 micrograms kg-1 (group B), ketamine at 5 mg kg-1 with midazolam at 0.1 mg kg-1 (group C), or medetomidine at 50 micrograms kg-1 (group D). For each test, the OCTT was defined by four methods: a visual assessment, the first maintained 4 ppm increase in hydrogen production, and the first maintained 0.5 ml hr-1 increase in hydrogen production assessed by two cumulative sum methods. Depending on the definition, the median OCTTs of the cats were between 113 and 131.5 minutes in group A, 86.5 and 97.5 minutes in group B, 218 and 235.5 minutes in group C and 86.5 and 97.5 minutes in group D. By two of the definitions, the median OCTTs in group C were significantly longer than in group A (P < or = 0.037) and approached significance by the other two definitions. The use of sedatives significantly increased the inter-individual variability of the OCTTs, particularly in groups C and D. There were significant differences between the median OCTTs defined by the four different methods, but all the methods were very highly and significantly correlated (rs < or = 0.9503, P < 0.0001).
Sparkes
A H
AH
Feline Centre, Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol.
Papasouliotis
K
K
Viner
J
J
Cripps
P J
PJ
Gruffydd-Jones
T J
TJ
D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology; D002415:Cats; D002432:Cecum; D004063:Digestion / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D006859:Hydrogen / Q000032:analysis; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D020926:Medetomidine; D008874:Midazolam / Q000494:pharmacology; D009055:Mouth; D010052:Ovariectomy; D012119:Respiration; D018709:Statistics, Nonparametric
D006993:Hypnotics and Sedatives; D007093:Imidazoles; D002047:Buprenorphine; D000075:Acepromazine; D007649:Ketamine; D006859:Hydrogen; D020926:Medetomidine; D008874:Midazolam