Polyarteritis nodosa and HIV infection: no evidence of a direct pathogenic role of HIV.
A case of polyarteritis nodosa identified by the American College of Rheumatology (ACR) 1990 criteria in a 44-year-old HIV-infected man is described. The search for cytomegalovirus, HBV and B19 parvovirus infections was negative. In situ hybridization did not reveal proviral HIV-1 DNA in a skin sample. A zidovudine-associated vasculitis was excluded. Corticosteroid therapy resolved vasculitis manifestations and was well tolerated without opportunistic infections during the 10-month follow-up period. An indirect pathogenetic role of HIV as a possible cause of vascular damage cannot be excluded in our patient.
Massari
M
M
Division of Infectious Disease, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Salvarani
C
C
Portioli
I
I
Ramazzotti
E
E
Gabbi
E
E
Bonazzi
L
L
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000302:isolation & purification; D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000150:complications*; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008297:Male; D016732:Parvovirus B19, Human / Q000302:isolation & purification; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000821:virology*; D011241:Prednisone / Q000627:therapeutic use; D015215:Zidovudine / Q000009:adverse effects
D000893:Anti-Inflammatory Agents; D015215:Zidovudine; D011241:Prednisone