Ehretianone, a novel quinonoid xanthene from Ehretia buxifolia with antisnake venom activity.
Ehretianone (1), a new quinonoid xanthene, together with known sterols, was isolated from a MeOH extract of the root bark of Ehretia buxifolia. The structure of ehretianone was elucidated as 7-hydroxy-9a alpha-(3-methylbut-2-enyl)-4a alpha,9 alpha-(2-methylprop-2-enyl)-4a, 9a-dihydro-1,4-dioxoxanthene on the basis of spectroscopic data and X-ray crystallographic analysis. The antisnake venom activity of ehretianone against Echis carinatus venom in mice is also reported.
Selvanayagam
Z E
ZE
Captain Srinivasa Murti Drug Research Institute for Ayurveda, Madras, India.
Gnanavendhan
S G
SG
Balakrishna
K
K
Rao
R B
RB
Sivaraman
J
J
Subramanian
K
K
Puri
R
R
Puri
R K
RK
D000818:Animals; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012910:Snake Venoms / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared; D014757:Viper Venoms / Q000037:antagonists & inhibitors / Q000633:toxicity; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D010936:Plant Extracts; D011809:Quinones; D012910:Snake Venoms; D014757:Viper Venoms; D014966:Xanthenes; C101805:ehretianone