Safety, tolerability, and efficacy of a glucose-insulin-potassium-magnesium-carnitine solution in acute myocardial infarction.
Fifty-four patients with AMI were treated with a front-loaded 15-hour infusion of hypertonic glucose, insulin, potassium, magnesium, and L-carnitine in addition to usual therapy. This metabolic solution was well tolerated, free of serious side effects, and reduced the incidence of morbid events.
Arsenian
M A
MA
Addison Gilbert Hospital, Gloucester, Massachusetts, USA.
New
P S
PS
Cafasso
C M
CM
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002118:Calcium / Q000097:blood; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002331:Carnitine / Q000008:administration & dosage / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006982:Hypertonic Solutions; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D010758:Phosphorus / Q000097:blood; D011188:Potassium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D012449:Safety; D015912:Thrombolytic Therapy
D001786:Blood Glucose; D002317:Cardiovascular Agents; D004232:Diuretics; D006982:Hypertonic Solutions; D007004:Hypoglycemic Agents; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D010758:Phosphorus; D005665:Furosemide; D008274:Magnesium; D005947:Glucose; D011188:Potassium; D002331:Carnitine; D002118:Calcium