[The correlational analysis assessment of exacerbation in bronchial asthma and treatment efficacy].
Blood and sputum eosinophils, eosinophilic cation protein (ECP) in the serum and OPV1 were measured in 30 patients with atopic bronchial asthma (BA) of moderate severity showing eosinophilia at the beginning and the end of treatment week 1 and 4, respectively. In exacerbation of BA relative number of blood eosinophils averaged 10.4 + -1.4%, sputum 35.2 + -5.6%. Serum concentration of ECP, OPV1, IgE averaged 42.6% + -11.9%, 66.8 + -6.3%, 753.7 + -114 IU/ml, respectively. In exacerbation a strong correlation is noted between relative number of eosinophils in the blood and sputum, between the levels of IgE and ECP. At the end of the treatment OPV1 was higher while ECP level in the serum went down. Reduced eosinophilia in the blood and sputum correlated with OPV1 increment. In BA patients with high blood and sputum eosinophilia function of the lungs depends on eosinophilic number, while in normalization of blood eosinophil concentration and in a sharp fall of sputum eosinophil number OPV1 changes correlation with changes in ECP in the course of treatment. A close correlation between changes in eosinophil count, FVD indices, IgE and ECP levels during the treatment indicate relief of inflammation in BA patients.
Anaev
E Kh
EKh
Cherniaev
A L
AL
Chernik
A V
AV
Chuchalin
A G
AG
D000328:Adult; D001249:Asthma / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D001798:Blood Proteins / Q000032:analysis; D002908:Chronic Disease; D003131:Combined Modality Therapy; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012119:Respiration; D012260:Ribonucleases; D013183:Sputum / Q000166:cytology
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D007073:Immunoglobulin E; D012260:Ribonucleases
Otsenka s pomoshch'iu korreliatsionnogo analiza obostreniia bronkhial'noĭ astmy i éffektivnosti lecheniia.