[A study of the association between EBV and B-cell lymphoma].
Extensive studies have demonstrated that Epstein-Barr virus (EBV) is associated with Burkitt's lymphoma, immunodeficiency related lymphoma, Hodgkin's disease and T-cell lymphoma. In order to investigate whether an association exists between EBV and B-cell lymphoma in patients without overt immunodeficiency, we examined 127 B-cell lymphomas without overt immunodeficiency for expression of EBV-encoded small RNA (EBER-1) using RNA/RNA in situ hybridization. EBER-1 expression was found in nuclei of tumor cells in 8 of 127 cases (6.3%) of B-cell lymphomas. This result is similar to that of studies in Europe and the United States (about 5%). The low frequency of EBV in B-cell lymphomas suggests that EBV does not pay an important role in the pathogenesis of B-cell lymphomas without overt immunodeficiency.
Zhou
X
X
Department of Pathology, Beijing Hospital.
Zhang
J
J
Yan
Q
Q
D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D016393:Lymphoma, B-Cell / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D014412:Tumor Virus Infections
D012367:RNA, Viral