Oxidatively modified LDL and atherosclerosis: an evolving plausible scenario.
Much evidence has accumulated that implicates the oxidative modification of low-density lipoprotein (LDL) in the early stages of atherogenesis. The antioxidant nutrients alpha-tocopherol, ascorbic acid, and betacarotene have been shown to inhibit in vitro LDL oxidation. In addition, they have been shown to increase the resistance of LDL to oxidation when given to animals and humans. Because plasma levels of these nutrients can be increased by dietary supplementation with minimal side effects, they may show promise in the prevention of coronary artery disease.
Jialal
I
I
Center for Human Nutrition, University of Texas--Southwestern Medical Center, Dallas 75235-9052, USA.
Fuller
C J
CJ
D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D004032:Diet; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*
D000975:Antioxidants; D008077:Lipoproteins, LDL