[Glutamine dipeptide enriched nutritional solutions attenuate bacterial translocation in rats after 60% intestinal resections].
OBJECTIVE
To investigate the effects of alanyl-glutamine dipeptide (Ala-Gln) enriched parenteral nutrition solution on intestinal mucosa or gut barrier since traditional parenteral nutrition leads to bacterial translocation.


METHODS
The moderate operation stress was induced by 60% resection of small intestine. Qualified rats distributed in three groups: Chow group (n = 10) received standard rat chow, PN group (n = 10) received traditional parenteral nutrition solution only, and Ala-Gln group (n = 10) received glutamine dipeptide enriched nutritional solutions (3% Ala-Gln). Rats were maintained on their respective diets for 7 days.


RESULTS
Chow group and Ala-Gln group maintained serum glutamine concentration, villus height and mucosal thickness. The bacterial translocation rate in Chow group and Ala-Gln group was 20% and in PN group 70%.


CONCLUSIONS
Results demonstrate that Ala-Gln enriched nutritional solutions maintain intestinal adaptation and gut barrier function after massive intestinal resection.
Bai
M
M
Department of Surgery, Peking Union Medical College Hospital, Beijing.
Jiang
Z
Z
Ma
Y
Y
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology*; D007421:Intestine, Small / Q000382:microbiology / Q000601:surgery; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*
D004151:Dipeptides; C054122:alanylglutamine