Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4.
Bone morphogenetic protein-4 (BMP-4) is thought to play an important role in early Xenopus development by acting as a "ventralizing factor' and as an epidermal determinant: local inhibition of BMP-4 function in whole embryos causes the formation of an additional dorsal axis, and inhibition of BMP-4 function in isolated ectodermal cells causes the formation of neural tissue. In this paper we describe a homeobox-containing gene whose expression pattern is similar to that of BMP-4, whose expression requires BMP-4 signalling and which, when over-expressed, causes a phenotype similar to that caused by over-expression of BMP-4. We suggest that this gene, which we call Xom, acts downstream of BMP-4 to mediate its effects.
Ladher
R
R
Division of Developmental Biology, National Institute for Medical Research, London, UK.
Mohun
T J
TJ
Smith
J C
JC
Snape
A M
AM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D018076:DNA, Complementary; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D006133:Growth Substances / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics*; D014981:Xenopus; D029867:Xenopus Proteins; D000099176:Noggin Protein
D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D018076:DNA, Complementary; D006133:Growth Substances; D018398:Homeodomain Proteins; D011506:Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; D000099176:Noggin Protein; C099992:ventx2.1 protein, Xenopus