The effect of sodium lauryl sulphate and triclosan on hamster cheek pouch mucosa.
It has recently been shown that triclosan protects the human skin from the inflammation that may be caused by exposure to sodium lauryl sulphate (SLS). The aim of the present study was to examine whether triclosan can protect the hamster cheek pouch mucosa from the irritation caused by exposure to SLS. After four daily applications of a paste containing SLS, the epithelium of the hamster cheek pouch showed consistently prominent structural changes, especially basal hyperplasia, acanthosis, hypergranulosis, and hyperkeratosis. Identical morphological changes were also observed after applications of a paste containing SLS together with triclosan. In contrast, after applications of a paste containing triclosan alone, the cheek pouch mucosa revealed a histological structure essentially similar to the non-treated control mucosa. From these results, we may conclude that SLS, but not triclosan, irritates the hamster cheek pouch epithelium. Moreover, triclosan does not protect the cheek pouch mucosa against structural changes induced by SLS. It must be taken into account that triclosan does not always offer protection against the side-effects of SLS.
Baert
J H
JH
Interdisciplinary Research Center, Katholieke Universiteit Leuven, Belgium.
Veys
R J
RJ
Ampe
K
K
De Boever
J A
JA
D000818:Animals; D002610:Cheek / Q000473:pathology; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009059:Mouth Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D012967:Sodium Dodecyl Sulfate / Q000633:toxicity*; D013501:Surface-Active Agents / Q000633:toxicity*; D014260:Triclosan / Q000494:pharmacology / Q000627:therapeutic use*
D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan