title: Depletion of stromal and intraepithelial antigen-presenting cells in cervical neoplasia in human immunodeficiency virus infection.
abstract: Human immunodeficiency virus-positive (HIV+) women have an increased risk of lower genital tract dysplasia and neoplasia, and studies of the central lymphoid system suggest that impaired immunosurveillance plays a role in the development of their cervical tumors. Intraepithelial and stromal immunocompetent cell counts were compared in cervical specimens from 50 HIV+ and 50 appropriately matched HIV-women (controls) with low and high grade squamous intraepithelial lesions (SIL), or carcinoma. Each histological class of HIV+ women displayed fewer intraepithelial Langerhans' (S100+) cells (LC) (as already known), and also fewer stromal LC and both intraepithelial and stromal (CD68+) macrophages. LC and macrophages were reduced in all HIV+ patients, whereas reduction of cervical T lymphocytes was found in only immunocompromised subjects (peripheral blood CD4+ T-cell count < 500/microL). A mucosal quantitative deficiency of antigen-presenting cells (APC) thus precedes that of T cells. HIV infection appears to lead to early impairment of mucosal immunoreactivity mainly because of defective antigen presentation. This impairment may be one mechanism underlying the increased frequency of cervical dysplasia/neoplasia, and the enhanced aggressiveness of invasive cancers in HIV+ women.
authors: Department of Pathology, G. D'Annunzio University, Chieti, Italy.
authors: S
authors: S
authors: Rosini
authors: S
authors: S
authors: Caltagirone
authors: G
authors: G
authors: Tallini
authors: G
authors: G
authors: Lattanzio
authors: R
authors: R
authors: Demopoulos
authors: M
authors: M
authors: Piantelli
authors: P
authors: P
authors: Musiani
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000938:Antigen-Presenting Cells / Q000473:pathology; D002452:Cell Count; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D009092:Mucous Membrane / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000473:pathology*