Neodymium:YAG laser lens ablation in a rabbit model.
OBJECTIVE
To assess the safety of neodymium:YAG (Nd:YAG) laser lens ablation in a rabbit model prior to human investigation.


METHODS
The Nd:YAG laser lens ablation probe was inserted into the anterior chamber of 14 New Zealand white rabbit eyes and Nd:YAG laser lens ablation was simulated, exposing the eyes to energy significantly higher than that used in previous experimental Nd:YAG lens ablation of the human crystalline lens. After the procedure, the rabbits were killed at 1 hour, 1 day, or 1 week and the eyes evaluated by specular microscopy, ultrasonic pachymetry, and light microscopy.


RESULTS
There was no statistically significant difference in the postoperative endothelial cell counts or ultrasonic pachymetry of study eyes and control (unoperated) eyes. Light microscopy revealed no apparent damage to the cornea, trabecular meshwork, or retina of the study eyes.


CONCLUSIONS
the Nd:YAG laser lens ablation device appears to be a safe method of cataract removal in this animal model. Further study is needed to determine the safety and efficacy of this device for cataract removal in humans.
Sperber
L T
LT
Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, New York, New York, USA.
D000818:Animals; D002387:Cataract Extraction / Q000379:methods*; D003315:Cornea / Q000473:pathology; D004728:Endothelium, Corneal / Q000473:pathology; D053685:Laser Therapy / Q000379:methods*; D007908:Lens, Crystalline / Q000601:surgery*; D011817:Rabbits; D012160:Retina / Q000473:pathology; D014129:Trabecular Meshwork / Q000473:pathology