[Use of parameters of E-rosette formation and electrophoretic mobility for comprehensive evaluation of the functional state of leukocytes].
The influence of some drugs on E-rosette formation by lymphocytes and on electrophoretic mobility of neutrophilic leukocytes has been studied. It has been found, that the character of drugs influence coincides with common directivity of their action on two main cell signalling systems: adenylate cyclase and polyphosphoinositide. The possibility of use of the parameters studied for the complex evaluation of functional state of leukocytes is discussed.
Metelitsa
L A
LA
Kalashnikova
L E
LE
Mogilevich
S A
SA
Luĭk
A I
AI
D000262:Adenylyl Cyclases / Q000097:blood; D000818:Animals; D002450:Cell Communication; D004586:Electrophoresis; D005069:Evaluation Studies as Topic; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000276:immunology*; D018129:Phosphatidylinositol Phosphates / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D018129:Phosphatidylinositol Phosphates; D000262:Adenylyl Cyclases
Ispol'zovanie pokazateleĭ obrazovaniia E-rozetok i élektroforeticheskoĭ podvizhnosti dlia kompleksnoĭ otsenki funktsional'nogo sostoianiia leĭkotsitov.