Neuroleptic malignant syndrome postoperative onset due to levodopa withdrawal.
Neuroleptic malignant syndrome is a potentially fatal disorder that may develop in the perioperative period. A case is described in which discontinuation of chronic levodopa therapy precipitated the postoperative development of this syndrome. The differential diagnosis and management principles are reviewed.
Young
C C
CC
Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Kaufman
B S
BS
D000758:Anesthesia; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D009466:Neuromuscular Blocking Agents; D011183:Postoperative Complications / Q000209:etiology*; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000503:physiopathology
D000978:Antiparkinson Agents; D009466:Neuromuscular Blocking Agents; D007980:Levodopa