title: Outbreak of vertigo in Wyoming: possible role of an enterovirus infection.
abstract: An epidemiologic investigation was conducted to characterize and evaluate the possibility of a viral aetiology of an outbreak of acute vertigo in Hot Springs Country, Wyoming, during autumn 1992. Case-finding identified Hot Springs County residents who sought medical attention for new onset vertigo during 1 August, 1992-31 January 1993. Thirty-five case-patients and 61 matched controls were interviewed and serum specimens were obtained during January 1993. Case-patients were more likely than controls to report symptoms (e.g. fatigue, sore throat, fever, diarrhoea) of antecedent acute illness. Case-patients did not have a significantly greater prevalence or mean titre of IgG antibodies to respiratory syncytial virus, parainfluenza viruses, Epstein-Barr virus, and cytomegalovirus than controls. Serologic evidence of recent enterovirus infection (IgM antibodies) was found for 74% of case-patients compared with 54% of controls (P < 0.05), suggesting a possible association between vertigo and enterovirus infection. Future studies are needed to define the role of enteroviruses in innerear diseases.
authors: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors: L
authors: L
authors: Simonsen
authors: A S
authors: AS
authors: Khan
authors: H E
authors: HE
authors: Gary
authors: C
authors: C
authors: Hanson
authors: M A
authors: MA
authors: Pallansch
authors: S
authors: S
authors: Music
authors: R C
authors: RC
authors: Holman
authors: J A
authors: JA
authors: Stewart
authors: D D
authors: DD
authors: Erdman
authors: N H
authors: NH
authors: Arden
authors: I K
authors: IK
authors: Arenberg
authors: L B
authors: LB
authors: Schonberger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D004196:Disease Outbreaks; D004770:Enterovirus / Q000276:immunology; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014717:Vertigo / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D014959:Wyoming / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M