title: Effect of bupivacaine-induced spinal block on the hypnotic requirement of propofol.
abstract: The hypnotic dose-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic or lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.
authors: Department of Anesthesia and Intensive Care, Rebecca Sieff' Government Hospital, Safed, Israel.
authors: M
authors: M
authors: Tverskoy
authors: G
authors: G
authors: Fleyshman
authors: L
authors: L
authors: Bachrak
authors: I
authors: I
authors: Ben-Shlomo
mesh_terms: D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D002045:Bupivacaine; D015742:Propofol