title: Synchronous patchy pattern of gene expression for adenylyl cyclase and phosphodiesterase but discrete expression for G-protein in developing rat striatum.
abstract: The ontogeny of the gene expression for striatal adenylyl cyclase (AC), 63 kDa calmodulin-dependent phosphodiesterase (63 kDa CaM-PDE) and olfactory G-protein (Golf), all of which are expressed predominantly in the striatum, was studied by in situ hybridization histochemistry. In the peri- and early postnatal striatum, the gene expression for striatal AC and 63 kDa CaM-PDE showed a patchy pattern corresponding to the striatal patchy compartments enriched in several molecules involved in cAMP-signaling system including DARPP-32 (a dopamine and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein with an apparent M(r) of 32,000). On the other hand, Golf showed a homogeneous expression pattern throughout the striatal development. The present finding suggests that the gene expression for the three molecules directly involved in the cAMP-generating and degrading system is differentially regulated during the striatal development.
authors: Department of Anatomy, Tohoku University.
authors: H
authors: H
authors: Sakagami
authors: Y
authors: Y
authors: Sawamura
authors: H
authors: H
authors: Kondo
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000096:biosynthesis*; D000262:Adenylyl Cyclases / Q000096:biosynthesis*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D003342:Corpus Striatum / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D005314:Embryonic and Fetal Development; D005260:Female; D019204:GTP-Binding Proteins / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D005865:Gestational Age; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology / Q000502:physiology; D015345:Oligonucleotide Probes; D009928:Organ Specificity; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases