Deciphering the alphabet of G proteins: the structure of the alpha, beta, gamma heterotrimer.
The recent independent structure elucidations of two heterotrimeric G proteins represent a milestone in our understanding of the regulation of this important class of signal switch molecules. The results show how the introduction of GTP into the heterotrimer produces two signalling molecules: the G alpha-GTP and G beta, gamma subunits.
Wittinghofer
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Max-Planck-Institut Für molekulare Physiologie, Dortmund, Germany.
D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D011487:Protein Conformation
D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins