title: ["Autoantibodies" and cell aging. Does malonic dialdehyde constitute an immunological marker of cell aging?].
abstract: Malondialdehyde (MDA), a lipid peroxidation product, reacts with free amino groups of proteins to give amino-3-iminopropene (AIP) bridges which are immunogenic. Antibodies reacting specifically with MDA-crosslinked proteins preexist in the sera of healthy human subjects, and we hypothesize that they are implicated in processes of senescent cells recognition and elimination. Results obtained by immunofluorescence and flow cytometry show an immunological response against structures arising on cell membranes from MDA reaction with free amino groups of proteins. Such structures might also be implicated in autoimmunity.
authors: Unité de Radiobiochimie, Centre de Recherches du Service de Santé des Armées, La Tronche.
authors: Y
authors: Y
authors: Chancerelle
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers; D016922:Cellular Senescence / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D008315:Malondialdehyde; D008856:Microscopy, Fluorescence
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D008315:Malondialdehyde
vernacular_title: "Autoanticorps" et sénescence cellulaire. Le dialdéhyde malonique constitue-t-il un marqueur immunologique du vieillissement cellulaire?