[Expression of apoptosis-related gene products in human brain tumors and apoptosis-inducing therapy].
To elucidate the mechanism of apoptosis in brain tumors, we analyzed the expression of apoptosis-related gene products in cultured glioma cells and biopsied brain tumor specimens. Fas, Bcl-2 family (Bcl-2, Bcl-x and Bax) and ICE family (ICE, Ich-1) were found to be involved in tumorigenesis of certain brain tumors. It was also clarified that OK-432 activated mononuclear cells could kill T98G glioblastoma cells by apoptotic mechanism through the Fas ligand/Fas system.
Tabuchi
K
K
Department of Neurosurgery, Saga Medical School.
Shiraishi
T
T
Toda
K
K
Kawaguchi
S
S
D017209:Apoptosis / Q000235:genetics*; D001483:Base Sequence; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016219:Immunotherapy, Adoptive; D007963:Leukocytes, Mononuclear; D008969:Molecular Sequence Data; D010844:Picibanil / Q000627:therapeutic use; D011518:Proto-Oncogene Proteins; D015843:Serpins; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D014764:Viral Proteins; D019014:fas Receptor
D011518:Proto-Oncogene Proteins; D015843:Serpins; D014764:Viral Proteins; D019014:fas Receptor; D010844:Picibanil; C074641:interleukin-1beta-converting enzyme inhibitor