Hemolysis due to the simultaneous occurrence of passenger lymphocyte syndrome and a delayed hemolytic transfusion reaction in a liver transplant patient.
Hemolysis due to donor-derived antibodies produced by "passenger" B lymphocytes, called passenger lymphocyte syndrome, has been described in ABO-unmatched solid organ and bone marrow transplant recipients. Delayed hemolytic transfusion reactions occur within a similar time frame and have similar clinical and serologic findings. To our knowledge, we report the first case of hemolysis due to the simultaneous occurrence of passenger lymphocyte syndrome (donor-derived anti-A) and a delayed hemolytic transfusion reaction (recipient-produced anti-E) in a liver transplant patient.
Jacobs
L B
LB
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287-6667, USA.
Shirey
R S
RS
Ness
P M
PM
D000017:ABO Blood-Group System / Q000276:immunology; D000743:Anemia, Hemolytic / Q000209:etiology*; D001402:B-Lymphocytes / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000276:immunology; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014181:Transplantation Immunology
D000017:ABO Blood-Group System; D007518:Isoantibodies