title: Isochromosome 7q and trisomy 8 are consistent primary, non-random chromosomal abnormalities associated with hepatosplenic T gamma/delta lymphoma.
abstract: Four patients with hepatosplenic T gamma/delta lymphoma, a rare but distinct entity of peripheral T cell lymphoma, are reported on. In each case, cytogenetic studies showed the presence of an Isochromosome 7q and a trisomy 8. A few chromosome studies have previously been reported in this lymphoma subtype but comparison with these published cases confirms that isochromosome 7q and trisomy 8 are primary, non-random chromosomal abnormalities in hepatosplenic T gamma/delta lymphoma.
authors: Laboratoire de Génétique, CHU Nancy, Vandoeuvre, France.
authors: P
authors: P
authors: Jonveaux
authors: M T
authors: MT
authors: Daniel
authors: V
authors: V
authors: Martel
authors: O
authors: O
authors: Maarek
authors: R
authors: R
authors: Berger
mesh_terms: D000293:Adolescent; D000328:Adult; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016130:Immunophenotyping; D018404:Isochromosomes; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics*; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013160:Splenic Neoplasms / Q000235:genetics*; D014314:Trisomy
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta