title: Long-term stability of cimetidine in total parenteral nutrition.
abstract: The stability of cimetidine (Tagamet) was investigated in total parenteral nutrition (TPN) mixtures containing different amino acid sources. TPN mixtures were stored at 5 degrees C in ethylvinyl acetate bags for 28 days and analysed by stability-indicating high-pressure liquid chromatography. Results indicated that cimetidine was physically compatible and chemically stable (less than 5% degradation) for at least 28 days in TPN mixtures containing either Freamine III, Vamin 14 or Aminoplex 12 as the amino acid source.
authors: Medicines Research Unit, School of Health and Community Studies, University of Derby, U.K.
authors: M C
authors: MC
authors: Allwood
authors: H J
authors: HJ
authors: Martin
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage; D002927:Cimetidine / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D010289:Parenteral Nutrition, Total; D013997:Time Factors
chemical_list: D000596:Amino Acids; D006635:Histamine H2 Antagonists; D002927:Cimetidine