title: [Myotonin protein kinase].
abstract: The mutation underlying myotonic dystrophy is the expansion of polymorphic CTG repeat in the 3'-noncoding region of the myotonin protein kinase (MtPK) gene mapping to chromosome 19q13.3. A full-length cDNA of human MtPK was cloned and expressed in COS-1 cells. MtPK is recovered from the COS cell extract as a 70 kDa protein, which coincides with the size deduced from the predicted amino acid sequence. Biochemical characteristics of MtPK expressed in COS cells and its expression are investigated.
authors: Institute of Molecular and Cellular Biosciences, University of Tokyo.
authors: S
authors: S
authors: Ishiura
authors: N
authors: N
authors: Sasagawa
authors: N
authors: N
authors: Saitoh
authors: H
authors: H
authors: Koike
authors: H
authors: H
authors: Sorimachi
authors: K
authors: K
authors: Suzuki
authors: M
authors: M
authors: Shimokawa
authors: F
authors: F
authors: Usuki
authors: H
authors: H
authors: Nakase
authors: K
authors: K
authors: Kamakura
mesh_terms: D002888:Chromosomes, Human, Pair 19; D004247:DNA; D006801:Humans; D009154:Mutation; D009223:Myotonic Dystrophy / Q000209:etiology*; D065636:Myotonin-Protein Kinase; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D018911:Trinucleotide Repeats
chemical_list: C585517:DMPK protein, human; D004247:DNA; D011494:Protein Kinases; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases