Seroepidemiology of chronic fatigue syndrome: a case-control study.
We performed serological testing for a large number of infectious agents in 26 patients from Atlanta who had chronic fatigue syndrome (CFS) and in 50 controls matched by age, race, and sex. We did not find any agent associated with CFS. In addition, we did not find elevated levels of antibody to any of a wide range of agents examined. In particular, we did not find elevated titers of antibody to any herpesvirus, nor did we find evidence of enteroviral exposure in this group of patients.
Mawle
A C
AC
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Nisenbaum
R
R
Dobbins
J G
JG
Gary
H E
HE
Stewart
J A
JA
Reyes
M
M
Steele
L
L
Schmid
D S
DS
Reeves
W C
WC
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000908:Antibodies, Fungal / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D015748:Borrelia burgdorferi Group / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D016022:Case-Control Studies; D015673:Fatigue Syndrome, Chronic / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D000908:Antibodies, Fungal; D000914:Antibodies, Viral