title: Does this have a familiar RING?
abstract: The RING finger is a zinc-binding domain that is found in proteins from plants to humans, but whose function remains largely enigmatic. The domain itself is distinct from other zinc-finger motifs in terms of sequence homology, zinc-ligation scheme and three-dimensional structure. It appears that the RING is involved in mediating protein-protein interactions and in some cases multi-protein complexes, which might depend on the presence of other proteins and/or domains.
authors: Protein Structure Laboratory, Imperial Cancer Research Fund, London, UK.
authors: A J
authors: AJ
authors: Saurin
authors: K L
authors: KL
authors: Borden
authors: M N
authors: MN
authors: Boddy
authors: P S
authors: PS
authors: Freemont
mesh_terms: D001665:Binding Sites; D003545:Cysteine / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000378:metabolism; D008285:Major Histocompatibility Complex; D008667:Metalloproteins / Q000737:chemistry* / Q000378:metabolism; D008830:Microbodies / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D015398:Signal Transduction / Q000502:physiology; D015032:Zinc / Q000378:metabolism*; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D008667:Metalloproteins; D011506:Proteins; D015032:Zinc; D003545:Cysteine