title: Frequency and type of reactions to antituberculosis drugs: observations in routine treatment.
abstract: METHODS
  United Kingdom, 1978-1992.
  
  
  OBJECTIVE
  To assess the incidence and type of reactions to antituberculosis drugs in an unselected series of patients.
  
  
  METHODS
  All patients treated for tuberculosis had details of drug treatment, durations and side-effects requiring alteration of treatment available. The data was compiled retrospectively for 1978-1980 patients and prospectively thereafter. Analysis of drug reactions was by drug, total months drug use, by age, sex and ethnic group, and reaction type.
  
  
  RESULTS
  Of 1317 patients 67 (5.1%) had 70 reactions to antituberculosis drugs requiring modification of treatment. The frequency of drug reactions increased from 2.3% at age 0-19 to 4.6% at age 20-39, 7.1% for age 40-59 and to 8.4% for those aged 60 and over. Females had significantly higher reactions rates than males. White patients had higher reaction rates than Pakistani and Indian patients, mainly due to the average age being greater.
  
  
  CONCLUSIONS
  The drug reaction rate of 5.1% in this largely prospective study is lower than that reported in other unselected series in the UK and other countries.
authors: Chest Clinic, Blackburn Royal Infirmary, UK.
authors: L P
authors: LP
authors: Ormerod
authors: N
authors: N
authors: Horsfield
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000208:ethnology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D003875:Drug Eruptions / Q000208:ethnology / Q000209:etiology*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000208:ethnology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000208:ethnology; D011446:Prospective Studies; D012189:Retrospective Studies; D012737:Sex Factors; D013997:Time Factors
chemical_list: D000995:Antitubercular Agents