[How to prove the role of renal artery stenosis as a cause of arterial hypertension].
A renal artery stenosis is definitely responsible for hypertension when the correction of stenosis has resulted in the cure of hypertension. Imputability strategy consists in prior collection of indirect data allowing to predict the efficiency of surgical or angioplasty repair, leading to treatment indications. This strategy is based upon the pathophysiological link between hemodynamic abnormalities, increased renin secretion downstream the stenosis, and hypertension. Imputability methods are designed to examine the renine-dependency of hypertension, and both asymmetric renin secretion and renal hemodynamics if stenosis is unilateral. This asymmetry could be enhanced by acute converting enzyme inhibition. Imputability and screening strategies could be fruitfully associated in high risk patients.
Laville
M
M
Service de néphrologie et hypertension artérielle, Hôpital Edouard-Herriot, Lyon.
D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D011877:Radionuclide Imaging; D012078:Renal Artery Obstruction / Q000150:complications*; D012083:Renin / Q000378:metabolism; D012307:Risk Factors
D012083:Renin
Comment prouver la responsabilité d'une sténose artérielle rénale dans une hypertension artérielle.