Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities.
The norditerpenoid alkaloid lycaconitine (2) was synthesized from lycoctonine (3) and its affinity determined for two neuronal nicotinic acetylcholine receptor subtypes. The structure of 2 was confirmed by a combination of spectroscopic methods.
Jacyno
J M
JM
College of Pharmacy, Ohio Northern University, Ada 45810, USA.
Harwood
J S
JS
Lin
N H
NH
Campbell
J E
JE
Sullivan
J P
JP
Holladay
M W
MW
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
D000470:Alkaloids; D011978:Receptors, Nicotinic; C101813:lycaconitine