Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis.
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening diseases characterized by extensive epidermal destruction. The aim of our study was to investigate apoptosis in keratinocytes of patients with TEN and TEN/SJS overlap syndrome. Keratinocytes from TEN patients were found to undergo extensive apoptosis. These results suggest that cell destruction in TEN occurs as a result of apoptosis. Our findings suggest that apoptosis inhibitory agents may play an important part in the therapeutic strategy of TEN.
Paul
C
C
Department of Dermatology, Hôpital Henri Mondor, Créteil, France.
Wolkenstein
P
P
Adle
H
H
Wechsler
J
J
Garchon
H J
HJ
Revuz
J
J
Roujeau
J C
JC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000235:genetics; D004247:DNA / Q000235:genetics; D004253:DNA Nucleotidylexotransferase / Q000235:genetics; D006801:Humans; D015603:Keratinocytes / Q000648:ultrastructure*; D008875:Middle Aged; D009707:Nucleosomes / Q000235:genetics; D013262:Stevens-Johnson Syndrome / Q000235:genetics / Q000473:pathology*
D009707:Nucleosomes; D004247:DNA; D004253:DNA Nucleotidylexotransferase