Ondansetron in radiation therapy of brain tumor in children.
Ten children receiving 5 to 6 week courses of radiotherapy after brain tumor surgery were given ondansetron treatment for persistent nausea and emesis. All patients continued the ondansetron treatment until the end of their radiotherapy course. Nausea, emesis, appetite, and adverse events were scored throughout the ondansetron treatment period. Ondansetron was well tolerated by all patients and was effective at reducing symptoms in 60% of the children.
Lippens
R J
RJ
Center for Pediatric Oncology, University Hospital Nijmegen St. Radboud, The Netherlands.
Broeders
G C
GC
D000293:Adolescent; D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D001066:Appetite; D001254:Astrocytoma / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002528:Cerebellar Neoplasms / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000532:radiotherapy; D005260:Female; D018237:Germinoma / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D009325:Nausea / Q000517:prevention & control; D017294:Ondansetron / Q000009:adverse effects / Q000627:therapeutic use*; D010865:Pilot Projects; D011878:Radiotherapy / Q000009:adverse effects*; D014839:Vomiting / Q000517:prevention & control
D000932:Antiemetics; D017294:Ondansetron