Effects of pneumoperitoneum on splanchnic hemodynamics: an experimental study in pigs.
OBJECTIVE
To study the effects on splanchnic haemodynamics of pneumoperitoneum induced by carbon dioxide insufflation.


METHODS
Controlled experimental study.


METHODS
11 Pigs weighing 19-30 kg.


METHODS
The animals were divided into a control group (n = 4) and a experimental group (n = 7). Experimental animals were subjected to stepwise increasing intra-abdominal pressure from 0 mm Hg to 25 mm Hg by carbon dioxide insufflation.


METHODS
Portal venous blood flow, portal venous blood pressure, portal/hepatic vascular resistance, and gastrointestinal vascular resistance.


RESULTS
At 25 mm Hg portal venous blood flow was reduced (66% of baseline), and portal venous blood pressure and portal/hepatic vascular resistance were increased (360% and 650% of baseline, respectively). The increase in gastrointestinal vascular resistance was less pronounced.


CONCLUSIONS
Increased intra-abdominal pressure caused significant changes in the splanchnic haemodynamics. The risk was greater if the intra-abdominal pressure exceeded 15 mm Hg.
Rasmussen
I B
IB
Department of Surgery, University Hospital, Uppsala, Sweden.
Berggren
U
U
Arvidsson
D
D
Ljungdahl
M
M
Haglund
U
U
D000818:Animals; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011028:Pneumoperitoneum, Artificial; D011312:Pressure; D013152:Splanchnic Circulation / Q000502:physiology*; D013552:Swine