title: [High grade osteosarcoma of the lower limb. Complications and results of the treatment of 20 patients].
abstract: Over 11 years we treated 30 osteosarcomas: 20 of them were high grade non metastatic osteosarcomas of the lower limb, which were treated by neoadjuvant chemotherapy (Rosen T10, or OS 87 protocol of the French Society for Pediatric Oncology).
  
  
  METHODS
  There were 12 males and 8 females; the mean age was 19 years (range 12-51). The site of the tumor was the femoral neck (1 case), femoral diaphysis (2 cases), distal femur (12 cases), proximal tibia (4 cases), distal tibia (1 case), 3 were IIA and 17 IIB according to Enneking system. Conservative treatment was performed in 17 cases: there were 12 knee prostheses, 4 allografts and 1 knee arthrodesis with allograft.
  
  
  RESULTS
  a) Surgical complications: Mechanical complications occurred in 10 patients. The function was preserved 8 times. In 2 patients the knee became stiff. An infection occurred in 3 patients: a conservative treatment was possible in 2 of them with a fair result. In the third case, an above-the-knee amputation had to be done. b) Functional results were studied according to Enneking rating. 14 arthroplasties (12 done as first surgical treatment and 2 after mechanical complication) had a 68, 19 score. c) Oncologic results: 8 patients were good respondents and 12 patients were bad respondents to chemotherapy according to Huvos grading. One local relapse was observed which could be treated by mean of a second chemotherapy and a prosthetic reconstruction. The patient is still alive and disease-free at 7 years (9 years after the diagnosis of the osteosarcoma). 5 patients had distant metastasis (lung, bones, and brain). One out of 5 was good respondent and 4 out of 5 are presently dead. Using Kaplan Meier statistical analysis, the overall survival wzs 76.8 per cent and the event-free survival was 67.4 per cent at 80 months.
  
  
  CONCLUSIONS
  We preferred a simple prosthetic reconstruction without osseous sleeve or an intercalary allograft if possible: these procedures allow the patient very rapid autonomy to have despite a prolonged chemotherapy.
authors: Service de Traumatologie, Hôpital de Hautepierre, CHU de Strasbourg.
authors: S R
authors: SR
authors: Babin
authors: P
authors: P
authors: Simon
authors: A
authors: A
authors: Babin-Boilletot
authors: J P
authors: JP
authors: Bellocq
authors: L
authors: L
authors: Marcellin
authors: J C
authors: JC
authors: Dosch
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012086:Reoperation; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000009:adverse effects*
vernacular_title: Ostéosarcome de haut grade de malignité du membre inférieur. Complications et résultats du traitement de 20 patients.