[The relationship between the phenotype of tumor infiltrating cells and the prognosis in laryngeal cancer].
By using the method of immunohistochemical avidin-biotin-peroxidase complex (ABC), toluidine blue and HE staining, the infiltrated grade and dispersed feature about the T-lymphocytes, B-Lymphocytes, macrophages, langerhans cells, mast cells and eosinophils of peritumoral stroma were investigated in 82 cases with laryngeal carcinoma. A stepwise logistic regression analysis of eight clinicopathologic variables and the density of six kinds of tumor infiltrating cells in the study were analyzed with the clinical outcome of the patients. The results showed that T-lymphocytes was the major infiltrated cells. The other cells such as macrophages, langerhans cells, mast cells and eosinophils were also to be found in local infiltration, but the B-cell was scanty. All these cells except B-cell had significant effect on the 5-year survival rate of the patients. By the multivariate analysis, the peritumoral infiltrated eosinophils was the most influential variable affecting clinical outcome, followed by the peritumoral infiltrated T-lymphocytes and the tumor histologic grade. We concluded that tumor infiltrating cells played a critical role in local host antitumor immune reaction.
Li
Y
Y
Affiliated Hospital of Taishan Medical College. Taian.
Zhang
Q
Q
Wang
T
T
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000401:mortality; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000401:mortality; D016015:Logistic Models; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D015996:Survival Rate