Sprouting of A beta fibers into lamina II of the rat dorsal horn in peripheral neuropathy.
Cholera toxin beta-subunit conjugated to horseradish peroxidase was used to label the large myelinated (A beta) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, A beta fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of A beta input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.
Lekan
H A
HA
Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555-1069, USA.
Carlton
S M
SM
Coggeshall
R E
RE
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000648:ultrastructure*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000648:ultrastructure*