Nitric oxide and cancer.
The possibility that the overall process of carcinogenesis may be linked to the deficiency of nitric oxide in a biological cell is examined. A hypothetical model of how this might operate to produce subtle changes in a cell resulting in and/or facilitating carcinogenesis is suggested.
Chhatwal
V J
VJ
Department of Surgery, National University of Singapore.
Moochhala
S M
SM
Chan
S T
ST
Ngoi
S S
SS
D000818:Animals; D002471:Cell Transformation, Neoplastic; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011230:Precancerous Conditions / Q000503:physiopathology
D004791:Enzyme Inhibitors; D007527:Isoenzymes; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase