Psychostimulant-like effect of central microinjection of neurotensin on brain stimulation reward.
The curve shift method and the brain stimulation reward paradigm were used to dissociate reward and performance changes and determine whether unilateral ICV microinjection of neurotensin (3, 10, and 30 micrograms/10 microliters) produces neuroleptic- or psychostimulant-like effect on a dopamine-dependent behavior. At the highest dose tested, neurotensin potentiated brain stimulation reward, producing a significant time-dependent decrease in frequency threshold. Neurotensin also suppressed maximal rate of responding at every dose tested, suggesting that it was more effective at attenuating performance capability. These results suggest that a centrally acting neurotensin receptor agonist may specifically stimulate dopamine-dependent behaviors, producing psychostimulant-like effect that can be attenuated or masked by a suppression of performance capability.
Rompré
P P
PP
Centre de recherche, Hôpital du Sacré-Coeur, Montréal, Québec, Canada.
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D011619:Psychotropic Drugs / Q000008:administration & dosage; D051381:Rats; D012201:Reward
D014150:Antipsychotic Agents; D011619:Psychotropic Drugs; D009496:Neurotensin; D004298:Dopamine