Hepatic failure associated with imipramine therapy.
Imipramine is an antidepressant drug that is rarely associated with mild liver function abnormalities. These are usually minor and transient liver enzyme elevations which return to normal levels upon discontinuation of the drug. We describe a 48-year-old male who developed subfulminant hepatic failure after imipramine usage, with complete recovery within three months after discontinuation of the drug.
Ilan
Y
Y
Liver unit, Hadassah University Hospital, Jerusalem, Israel.
Samuel
D
D
Reynes
M
M
Tur-Kaspa
R
R
D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007099:Imipramine / Q000009:adverse effects* / Q000627:therapeutic use; D017093:Liver Failure / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine