Lineage-specific CaN19 expression in human skin: lack of expression in normal melanocytes.
Although expression of CaN19 is reduced in cell lines derived from tumors of diverse origin, its expression in their normal counterparts has not been studied in detail. We find that CaN19 mRNA is expressed at very low to undetectable levels in normal melanocytes as well as malignant melanoma cell lines, confirming that CaN19 expression in normal cells is lineage-dependent.
Andersen
L B
LB
Department of Dermatology, University of Michigan, Ann Arbor 48109-0314, USA.
Xia
L
L
Stoll
S
S
Zhao
X
X
Elder
J T
JT
D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism*; D008545:Melanoma / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger