Suberogorgin vs N-cyclohexyl suberogorgamide effects on urine, respiration, and blood pressure in rat and cat.
OBJECTIVE
To compare the pharmacological actions of suberogorgin (Sub) and N-cyclohexyl suberogorgamide (N-CS).


METHODS
Urine was collected from rats and anesthetized cats which had been loaded with water. The concentrations of Na+ and K+ in urine were determined in ICAP-9000 atomic emission spectrometry. An equitoxic (1/50 LD50) dose of Sub and N-CS was used in cats.


RESULTS
The cat urine was decreased by 63% after i.v. Sub 0.4 mg.kg-1, but increased by 25% after i.v. N-CS 1.5 mg.kg-1, lasting at least 9 h. Sub and N-CS increased the respiratory rate and tidal volume, but did not change the blood pressure. The rat urine was decreased by 48% after i.p. Sub 1.3 mg.kg-1, but increased by 14% after i.p. N-CS 3.2 mg.kg-1. Sub and N-CS increased the concentrations of Na+ and K+ in rat urine. These effects lasted at least 24 h.


CONCLUSIONS
Sub is an antidiuretic, while N-CS is a diuretic drug.
Peng
W D
WD
Department of Biology, Sun Yat-Sen University, Guangzhou, China.
Xu
S B
SB
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D013990:Tidal Volume / Q000187:drug effects; D014556:Urine
D002800:Cholinesterase Inhibitors; D004232:Diuretics; C099467:N-cyclohexylsuberogorgamide; D012717:Sesquiterpenes; C049055:suberogorgin; D012964:Sodium; D011188:Potassium