title: Phenol lumbar sympathetic block in diabetic lower limb ischemia.
abstract: BACKGROUND
  Patients with arteriosclerotic peripheral vascular disease and lower limb ischemia have painful ulceration or incipient gangrene of the lower limb with intractable rest pain. The arteriosclerotic changes may preclude any surgery other than amputation.
  
  
  METHODS
  We examined whether chemical sympathectomy could relieve pain, arrest gangrene and postpone amputation, even in diabetic patients.
  
  
  RESULTS
  Phenol lumbar sympathectomy was performed on 373 patients, of whom 226 (60.6%) were diabetic. Over 24-120 months of follow-up, 219 patients (58.7%) experienced total relief from pain and healing of gangrenous ulcers, although the treatment was unsuccessful in 154 patients. A favorable result was marked in diabetic patients who had rest pain and in non-diabetic patients who had digital gangrene or digital ulcers. Age and sex did not affect the results but heavy smoking did.
  
  
  CONCLUSIONS
  Phenol sympathectomy should be considered as an alternative to surgical sympathectomy. Furthermore, the technique may be a precursor to and even an alternative to amputation in patients who have diabetes and advanced arteriosclerosis of the lower limb.
authors: Vascular Surgery Unit, Kaplan Hospital, Rehovol, Israel.
authors: A
authors: A
authors: Mashiah
authors: D
authors: D
authors: Soroker
authors: S
authors: S
authors: Pasik
authors: T
authors: T
authors: Mashiah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D001161:Arteriosclerosis / Q000628:therapy*; D001340:Autonomic Nerve Block; D003925:Diabetic Angiopathies / Q000628:therapy*; D017719:Diabetic Foot / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005734:Gangrene; D006801:Humans; D007511:Ischemia / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D019800:Phenol; D010636:Phenols; D013565:Sympatholytics; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D010636:Phenols; D013565:Sympatholytics; D019800:Phenol