title: Reduction of aneurysm pressure and wall stress after endovascular repair of abdominal aortic aneurysm in a canine model.
abstract: A canine model was designed to evaluate the changes in abdominal aortic aneurysm (AAA) pressure and wall stress after endovascular repair. Eight canines underwent laparotomy and creation of an AAA. The aneurysm was then excluded with a transluminally placed endovascular graft (TPEG) inserted through the right femoral artery and deployed across the AAA to exclude the infrarenal aortic branches from aortic perfusion. Blood pressure and flow data were recorded for 6 hours. The AAA blood pressure decreased from 135 +/- 9.3 mm Hg before exclusion to 45 +/- 17.6 mm Hg at 10 minutes after exclusion (p < 0.001). At 6 hours, AAA blood pressure had declined further to 26 +/- 12.5 mm Hg. Blood flow in the excluded iliac artery decreased from a baseline of 242 +/- 58 ml/min to 41 +/- 29 ml/min 10 minutes after TPEG placement (p < 0.001). At 6 hours, flow was reduced to 12 +/- 3.5 ml/min (p < 0.05 compared with that at 10 minutes). Aortic wall stress was significantly reduced by TPEG placement but was only slightly lower than baseline aortic wall stress before AAA creation. The lumbar arteries were patent with retrograde flow in all cases and were found to be the major contributors to postexclusion aneurysm pressure. Endovascular AAA exclusion results in an immediate decrease in blood pressure and wall stress within the excluded aneurysm, but the aneurysm remains perfused by retrograde flow through the lumbar arteries, which resulted in near-baseline levels of aneurysm wall stress in this canine model. Embolization of patient lumbar vessels at prosthesis placement may further reduce the risk of late rupture.
authors: Department of Surgery, University of North Carolina at Chapel Hill School of Medicine 27599-7210, USA.
authors: W A
authors: WA
authors: Marston
authors: E
authors: E
authors: Criado
authors: C A
authors: CA
authors: Baird
authors: B A
authors: BA
authors: Keagy
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology / Q000601:surgery*; D001019:Aortic Rupture / Q000517:prevention & control; D001158:Arteries / Q000503:physiopathology; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004621:Embolization, Therapeutic; D006083:Graft Occlusion, Vascular / Q000209:etiology; D018056:Hemorheology; D007083:Iliac Artery / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000098:blood supply; D008297:Male; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D013927:Thrombosis / Q000209:etiology; D014654:Vascular Patency