title: Hemodynamic effects of partial liquid ventilation with perfluorocarbon in acute lung injury.
abstract: OBJECTIVE
  To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI).
  
  
  METHODS
  Randomized, prospective, double-control, experimental study. Experimental intensive care unit of a university.
  
  
  METHODS
  Eighteen large pigs (50 +/- 5 kg body weight) with an average anterior posterior thoracic diameter of 24 cm and induced acute lung injury.
  
  
  METHODS
  All animals were surfactant depleted by lung lavage to a PaO2 below 100 mmHg and randomized to receive either perflubron (n = 6) or saline (n = 6) in five intratracheal doses of 5 ml/kg at 20-min intervals, or no instillation (n = 6).
  
  
  RESULTS
  In all animals heart rate, arterial pressures, pulmonary pressures, cardiac output and blood gases were recorded at 20-min intervals. There was no deleterious effect on any hemodynamic parameter in the perflubron group, whereas systolic and mean pulmonary arterial pressure values showed a persistent decrease after the first 5 ml/kg of perflubron, from 48.7 +/- 14.1 to 40.8 +/- 11.7 mmHg and from 39.7 +/- 13.2 to 35.2 +/- 12.0 mmHg, respectively. Perflubron resulted in a significant (ANOVA P < 0.01), dose-dependent increase in PaO2 values from 86.3 +/- 22.4 to a maximum of 342.4 +/- 59.4 mmHg at a dose of 25 ml/kg; the other groups showed no significant increase in PaO2.
  
  
  CONCLUSIONS
  Tracheal instillation of perflubron in induced ALI results in a dose-dependent increase in PaO2 and has no deleterious effect on hemodynamic parameters.
authors: Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands.
authors: R J
authors: RJ
authors: Houmes
authors: S J
authors: SJ
authors: Verbrugge
authors: E R
authors: ER
authors: Hendrik
authors: B
authors: B
authors: Lachmann
mesh_terms: D000136:Acid-Base Equilibrium; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004655:Emulsions / Q000627:therapeutic use*; D005260:Female; D005466:Fluorocarbons / Q000627:therapeutic use*; D006439:Hemodynamics; D006842:Hydrocarbons, Brominated; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D012129:Respiratory Function Tests; D016683:Supine Position; D013552:Swine
chemical_list: D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron