Acute arterial thrombosis due to platelet aggregation in a patient receiving granulocyte colony-stimulating factor.
We describe a 44-year-old man with non-Hodgkin's lymphoma receiving granulocyte colony-stimulating factor (G-CSF) who developed an acute arterial thrombosis. The removed thrombus contained large amounts of platelet aggregation. A rapid increase of platelets and increased adenosine diphosphate (ADP)- and collagen-induced platelet aggregation were observed at the time of the thrombotic event. A challenge test of G-CSF showed an increase in the platelet count and an augmentation of ADP- and collagen-induced platelet aggregation. In the use of GCSF. patients who produce a rapid increase in platelet levels could be at greater risk for thrombotic events and need to be followed-up carefully.
Kawachi
Y
Y
Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
Watanabe
A
A
Uchida
T
T
Yoshizawa
K
K
Kurooka
N
N
Setsu
K
K
D000328:Adult; D001012:Aorta, Abdominal; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008297:Male; D010974:Platelet Aggregation; D010976:Platelet Count; D013922:Thrombocytosis / Q000209:etiology; D013927:Thrombosis / Q000209:etiology*
D016179:Granulocyte Colony-Stimulating Factor