title: Topical analgesia for superficial corneal injuries.
abstract: OBJECTIVE
  To assess the analgesic effects of a topical non-steroidal anti-inflammatory agent, flurbiprofen 0.03%, during healing after superficial corneal injuries.
  
  
  METHODS
  401 patients treated for corneal abrasion in a five month period were randomly allocated to one of four treatment groups: polyvinyl alcohol alone (control), homatropine 2%, flurbiprofen 0.03%, or homatropine 2% followed by flurbiprofen 0.03%. Treatments were given for 48 h. Ocular pain was recorded on a visual analogue scale by the patients over the first 24 h, and use of oral analgesics was also recorded. Usable responses were received from 224 patients (55.8%).
  
  
  RESULTS
  Patients treated with flurbiprofen had significantly lower pain scores for the 24 h duration of the study than controls (P < 0.05).
  
  
  CONCLUSIONS
  Flurbiprofen eye drops provide more effective pain relief than traditional treatments for superficial corneal injuries.
authors: Royal Eye Hospital, Manchester, United Kingdom.
authors: A K
authors: AK
authors: Brahma
authors: S
authors: S
authors: Shah
authors: V F
authors: VF
authors: Hillier
authors: D
authors: D
authors: McLeod
authors: T
authors: T
authors: Sabala
authors: A
authors: A
authors: Brown
authors: J
authors: J
authors: Marsden
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D065306:Corneal Injuries; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010147:Pain Measurement; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D011142:Polyvinyl Alcohol / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014326:Tropanes / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010276:Parasympatholytics; D014326:Tropanes; D005480:Flurbiprofen; C100236:homatropine; D011142:Polyvinyl Alcohol