title: Remodeling of bone around hydroxyapatite-coated femoral stems.
abstract: Two hundred and twenty-four total hip arthroplasties were performed in 201 patients with use of a femoral component with hydroxyapatite coating of the proximal portion of the stem. The mean duration of follow-up was seventy-one months (range, fifty-eight to eighty-seven months). Of the 224 arthroplasties, 208 (93 per cent; 190 patients) yielded a good or excellent clinical result. Four patients (2 per cent) reported mild-to-moderate activity-related pain in the thigh, and two (1 per cent) had aseptic loosening. The radiographic findings of progressive new-bone formation (cancellous condensation and cortical hypertrophy) throughout the zones adjacent to the middle and distal portions of the stem were evidence of early, extensive proximal fixation of the implant, with distal stress transfer through the implant, which is stiffer than the surrounding bone. Remodeling of the femur began early, was predictable, and progressed throughout the follow-up period. Cortical hypertrophy about the middle and distal portions of the stem occurred predominantly in the mediolateral plane (in 105 hips [47 per cent], compared with thirteen hips [6 per cent] in the anteroposterior plane), and it was more common in patients who had had poorer bone quality preoperatively. Intramedullary osteolysis was present in one femur (0.4 per cent) at five years; the osteolytic area was less than five millimeters in its greatest dimension and had not progressed at the time of the six-year follow-up evaluation. This low rate of osteolysis suggests that a circumferential coating of hydroxyapatite may effectively minimize migration of wear debris along the femoral stem. The progressive remodeling of the femur about the middle and distal portions of the stem, as evidenced by cancellous condensation and cortical hypertrophy, has not, to our knowledge, been described previously to this magnitude in association with proximally coated (porous or hydroxyapatite-coated) femoral implants.
authors: M. H. & D. Orthopedic Associates, Moon Township, Pennsylvania 15108, USA.
authors: J A
authors: JA
authors: D'Antonio
authors: W N
authors: WN
authors: Capello
authors: M T
authors: MT
authors: Manley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016723:Bone Remodeling / Q000187:drug effects*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology* / Q000601:surgery; D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D006882:Hydroxyapatites / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis; D011183:Postoperative Complications / Q000209:etiology; D011859:Radiography
chemical_list: D006882:Hydroxyapatites