Thymulin reduces hyperalgesia induced by peripheral endotoxin injection in rats and mice.
In a new model of peripheral localized inflammation, induced by intraplantar endotoxin (1.25 micrograms) injection in the hind paw of rats and mice, thymulin, a hormone of the thymus gland involved in immunomodulation, reduced inflammatory pain. High doses of thymulin reduced significantly, and in a dose-dependent manner, mechanical hyperalgesia as assessed by the paw pressure test and thermal hyperalgesia as assessed by the hot plate test and tail immersion test.
Safieh-Garabedian
B
B
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon. bared@layla.aub.ac.lb
Jalakhian
R H
RH
Saadé
N E
NE
Haddad
J J
JJ
Jabbur
S J
SJ
Kanaan
S A
SA
D000818:Animals; D004731:Endotoxins / Q000009:adverse effects*; D005684:Gait / Q000187:drug effects; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D013935:Thymic Factor, Circulating / Q000494:pharmacology*
D004731:Endotoxins; D013935:Thymic Factor, Circulating