Antenatal screening for cystic fibrosis.
OBJECTIVE
To assess the practicality of implementing antenatal screening for cystic fibrosis in Yorkshire.


METHODS
Prospective study in which all pregnant women were offered testing for the delta F508 mutation which accounts for about 85% of carriers in Yorkshire. The reproductive partners of those found to be cystic fibrosis carriers were then tested and any carrier referred for genetic counselling.


METHODS
Antenatal clinics in two hospitals and eight general practices.


METHODS
Six thousand and seventy-one pregnant women.


RESULTS
A total of 3773 women (62%) accepted the screening offer. This was a lower uptake rate than in other published UK studies: Aberdeen (85-91%), Manchester (85%), Edinburgh (76-84%) and Oxford (67%). Nonetheless there were large and statistically significant differences in the uptake rate between centres within the study: 78% and 60% for the two hospitals and 67% for the general practices. One hundred and thirty women (3.4%) were found to be carriers and three carrier couples were identified. The median time interval for the laboratory to produce a result was five days and the cost was pounds 16 on average.


CONCLUSIONS
Antenatal screening for cystic fibrosis does not pose any special practical difficulties. It would be feasible to introduce it into routine practice in Yorkshire.
Cuckle
H
H
Centre for Reproduction, Growth and Development, University of Leeds, UK.
Quirke
P
P
Sehmi
I
I
Lewis
F
F
Murray
J
J
Cross
D
D
Cuckle
P
P
Ozols
B
B
D001294:Attitude to Health; D003365:Costs and Cost Analysis; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000191:economics / Q000235:genetics; D004739:England; D005194:Family Practice; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D005820:Genetic Testing / Q000191:economics / Q000379:methods*; D006769:Hospitals, General; D006771:Hospitals, Maternity; D006801:Humans; D009154:Mutation; D010342:Patient Acceptance of Health Care; D017060:Patient Satisfaction; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000191:economics / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors