[Rhythmic component of twelve hours].
From observations made on the rhythms in different systems: changes in plasmatic concentrations of 5-fluorouracil administered at a constant rate, proliferative activity of human tissues (bone marrow and oral mucosa), actometry, variations of glutathione levels in the liver and kidney from ice, we show the existence of a 12 hours rhythmic component and we discuss the putative importance of this component.
Metzger
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G
Laboratoire des Rythmes Biologiques et de Chronothérapie, ICIG, Hôpital Paul-Brousse, Villejuif, France.
Li
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Mormont
C
C
Lévi
F
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D000328:Adult; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000097:blood* / Q000627:therapeutic use; D001854:Bone Marrow Cells; D019328:Buthionine Sulfoximine; D002455:Cell Division / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D003864:Depression, Chemical; D005260:Female; D005472:Fluorouracil / Q000097:blood* / Q000627:therapeutic use; D005978:Glutathione / Q000096:biosynthesis; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000502:physiology*; D009061:Mouth Mucosa / Q000166:cytology
D000963:Antimetabolites; D000964:Antimetabolites, Antineoplastic; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D005472:Fluorouracil
Composante rythmique de 12 heures.