title: The human leucocyte antigen (HLA) DR expression and the distribution of T-lymphocytes in the fimbriae of the normal fallopian tube and during pelvic adhesion disease.
abstract: OBJECTIVE
  Systematically to investigate the expression of human leucocyte antigen (HLA) DR on the columnar epithelium and the content of T-lymphocytes in the fimbriae specimens of the fallopian tube from healthy women and from women with infertility and pelvic adhesions.
  
  
  METHODS
  The staining of HLA-DR expression on the columnar epithelium was judged on a four-graded scale according to the distribution of HLA-DR expression. The amount and distribution of T-lymphocytes were registered.
  
  
  RESULTS
  The biopsies from normal fimbriae contained sparsely infiltrating T-lymphocytes. On the columnar epithelial cells a patchy HLA-DR expression was observed that was more widespread in preovulatory cases. In some biopsies from sactosalpinx, the HLA-DR expression was found completely to cover the columnar epithelial cells and was associated with a heavy infiltration of T-lymphocytes. CD4+ T-lymphocytes dominated in all but one adhesion biopsies.
  
  
  CONCLUSIONS
  The findings indicate an ongoing immunological activity in pelvic adhesions that might immunologically influence fertility.
authors: Department of Obstetrics and Gynecology, Nacka Hospital, Sweden.
authors: G A
authors: GA
authors: Edelstam
authors: A
authors: A
authors: Karlsson-Parra
mesh_terms: D000328:Adult; D001706:Biopsy; D004848:Epithelium / Q000276:immunology; D005187:Fallopian Tubes / Q000276:immunology*; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010388:Pelvis / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D000267:Tissue Adhesions / Q000276:immunology
chemical_list: D006684:HLA-DR Antigens