Clinically and electrodiagnostically pure sensory demyelinating polyneuropathy.
A 35-year-old woman presented with a 4 year history of stepwise sensory loss which progressed in an asymmetrical fashion (mononeuropathy multiplex) and developed into a relatively symmetric polyneuropathy which was purely sensory by clinical and electrodiagnostic criteria. Sural nerve biopsy revealed demyelination with axonal sparing. Extensive laboratory evaluation failed to reveal a definite cause. This case is unique among well-documented cases of chronic inflammatory demyelinating polyneuropathy (CIDP) in that it is purely sensory by both clinical and electrodiagnostic criteria, and may represent a distinct entity rather than an extension of the spectrum of CIDP.
Rubin
M
M
Department of Neurology, Hospital for Special Surgery, New York, NY, USA.
Mackenzie
C R
CR
D000328:Adult; D001369:Axons / Q000473:pathology / Q000502:physiology; D001706:Biopsy; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004568:Electrodiagnosis; D005121:Extremities / Q000294:innervation; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D006987:Hypesthesia / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D011115:Polyneuropathies / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000294:innervation; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology