title: Quantification of hemostatic proteins and activation products in synovial fluids from arthritic joints prior to and after induction of chemical synoviorthesis.
abstract: Synovial fluids drawn from joints of patients suffering from rheumatoid arthritis were investigated for their concentrations of proteins and activation markers of the complement, coagulation and fibrinolytic systems. A broad spectrum of plasmatic inhibitors and other hemostatic proteins were detectable by immunologic assays. Compared to normal plasma concentration ranges, levels of alpha 2-antiplasmin, antithrombin III, heparin-cofactor II, factor H, alpha 2-macroglobulin, inter-alpha-trypsin inhibitor, fibrinogen and particularly high molecular weight kininogen were found to be decreased when corrected for total protein content. However, highly elevated levels of C-reactive protein, factor XIII, PMN-elastase, prothrombin fragment F1+2, thrombin-antithrombin III, plasmin-antiplasmin and terminal complement-complexes as well as C5a were determined. Eight and 24 hours after induction of chemical synoviorthesis, a general increase in most of the parameters was observed. Statistically significant alterations were found for C1-inhibitor, factor H, alpha 1-antitrypsin, inter-alpha-trypsin inhibitor, factor XIII, protein C, thrombin-antithrombin III complexes and C5a.
authors: Centeon Pharma GmbH, Marburg, Germany.
authors: J
authors: J
authors: Römisch
authors: U
authors: U
authors: Krahl
authors: J
authors: J
authors: Hock
authors: J
authors: J
authors: Bläser
authors: R
authors: R
authors: Fricke
authors: U
authors: U
authors: Maasjosthusmann
authors: H
authors: H
authors: Tschesche
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D015415:Biomarkers / Q000737:chemistry; D001779:Blood Coagulation Factors / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects; D008297:Male; D013582:Synovial Fluid / Q000737:chemistry*; D013583:Synovial Membrane / Q000187:drug effects
chemical_list: D015415:Biomarkers; D001779:Blood Coagulation Factors; D001798:Blood Proteins; D003165:Complement System Proteins