Apolipoprotein E genotype in Spanish patients of Alzheimer's or Parkinson's disease.
Blood donors of the Madrid area show a 6% frequency of apolipoprotein E genotype carrying allele epsilon 4. This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages > 60 years. The frequency (34%) of the allele epsilon 4 was significantly increased in patients of late onset Alzheimer's disease, similarly to other populations. An earlier age of onset of the dementia is observed in the patients of late-onset Alzheimer's disease carrying the allele epsilon 4. No increased frequency in allele epsilon 4 frequency was found in patients of early-onset Alzheimer's disease. Patients of Parkinson's disease do not show any differences in the frequency of the alleles of apolipoprotein E when compared with healthy individuals.
Ibarreta
D
D
Department of Human Physiology and Molecular Genetics, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain.
Gómez-Isla
T
T
Portera-Sánchez
A
A
Parrilla
R
R
Ayuso
M S
MS
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016631:Lewy Bodies / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics*; D013030:Spain
D001057:Apolipoproteins E