[Comparative study of the immunogenicity of various forms of Naja oxiana cardiotoxin].
Comparative study of the immune sera from rabbits immunized with both formol and native cardiotoxins, cardiotoxin incorporated into sphingomyelin-phosphatidylcholine-cholesterol liposome stabilized with osmium tetroxide, and a cardiotoxin-succinylated bovine albumin conjugate was performed. The latter produced antibodies identified by immunodiffusion assay. The highest survival was observed in animals treated with antiserum to cardiotoxin-albumin conjugate, followed by antitoxin to combination of formol and native cardiotoxins. Antiserum to cardiotoxin in liposome was ineffective.
Danilenko
V S
VS
Mogireva
L A
LA
Bondarenko
B N
BN
Volkova
M Iu
MIu
Omel'ianenko
Z P
ZP
Dmitrenko
S A
SA
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002199:Capillary Permeability; D004179:Cobra Cardiotoxin Proteins / Q000276:immunology* / Q000493:pharmacokinetics; D007106:Immune Sera; D000922:Immunotoxins; D015394:Molecular Structure; D011233:Precipitin Tests; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D012867:Skin / Q000098:blood supply; D014614:Vaccines, Synthetic / Q000276:immunology*
D004179:Cobra Cardiotoxin Proteins; D007106:Immune Sera; D000922:Immunotoxins; D014614:Vaccines, Synthetic; D012710:Serum Albumin, Bovine
Sravnitel'noe izuchenie immunogennosti razlichnykh form kardiotoksina sredneaziatskoĭ kobry.