title: Microvascular function in type 2 (non-insulin-dependent) diabetes: improved vasodilation after one year of good glycaemic control.
abstract: Abnormalities of microvascular function may be important in the development of diabetic microangiopathy. The major functional abnormality identified in patients with Type 2 diabetes has been a marked limitation of microvascular vasodilation, which is present from the time of diagnosis. The effects of sustained improvements in glycaemic control on vasodilator capacity in Type 2 diabetes are unknown. Twelve Type 2 diabetic patients were studied prospectively for 1 year after diagnosis. The reduced maximum hyperaemic response to local heating of the foot skin present at the time of diagnosis remained unchanged after 3 months of improved glycaemic control (1.12 +/- 0.56 V at diagnosis vs 1.21 +/- 0.69 V at 3 months, mean +/- SD; p = 0.25), but was improved after 1 year (1.42 +/- 0.91 V; p = 0.04 vs 3 months). The percentage increase in maximum hyperaemia correlated with the percentage decrease in HbA1c (rs = 0.53, p = 0.04). These results suggest that the early microvascular abnormalities demonstrated in Type 2 diabetes are potentially reversible and provide a further reason for striving for optimal glycaemic control in this patient group.
authors: Department of Diabetes and Vascular Medicine, University of Exeter, UK.
authors: A J
authors: AJ
authors: Jaap
authors: C A
authors: CA
authors: Pym
authors: C
authors: C
authors: Seamark
authors: A C
authors: AC
authors: Shore
authors: J E
authors: JE
authors: Tooke
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D003925:Diabetic Angiopathies / Q000503:physiopathology* / Q000517:prevention & control; D005260:Female; D005528:Foot / Q000098:blood supply; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006940:Hyperemia; D008297:Male; D008833:Microcirculation / Q000503:physiopathology*; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin