Immunoendocrine aspects of anorexia nervosa.
The T-lymphocyte proliferative response to phytohemoagglutinin (PHA) stimulation was the same in 11 anorexic women, 6 restricted (AN-R) and 5 bulimic (AN-B), and in 11 sex- and age-matched controls, in basal conditions and after acute administration of corticotropin-releasing hormone (CRH). Basal plasma levels of ACTH and cortisol were higher in patients than in controls, while beta-endorphin (beta-EP), growth hormone (GH) and prolactin (PRL) concentrations did not differ in the two groups. ACTH and beta-EP responses to CRH stimulation were blunted in patients, while those of cortisol did not differ in the two groups. ACTH, beta-EP and cortisol responses to the dexamethasone suppression test were impaired in 55% of the patients. Baseline T-lymphocyte concentrations of cholecystokinin-8 (CCK-8) and beta-EP were measured in another group of 56 anorexics, 33 restricted and 23 bulimic, and in 24 controls. CCK-8 values were significantly lower and beta-EP values significantly higher in patients than in controls.
Brambilla
F
F
Dip. Scienze Neuropsichiche, 1st. Sci. S. Raffaele Universita, Milano, Italy.
Ferrari
E
E
Brunetta
M
M
Peirone
A
A
Draisci
A
A
Sacerdote
P
P
Panerai
A
A
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000856:Anorexia Nervosa / Q000276:immunology*; D002032:Bulimia / Q000276:immunology; D003346:Corticotropin-Releasing Hormone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007108:Immune Tolerance / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D011388:Prolactin / Q000097:blood; D012844:Sincalide / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology*; D001615:beta-Endorphin / Q000097:blood
D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003346:Corticotropin-Releasing Hormone; D012844:Sincalide; D006854:Hydrocortisone