[Overexpression of c-Fos induces apoptosis of CD43+ pro-B cells].
The proto-oncogene product c-Fos, a component of the transcription factor AP-1, is induced in early B lineage cells. In order to investigate a role of the c-Fos in early B cell development, fetal liver (FL) cells from transgenic mice carrying an IFN-inducible c-fos gene (Mx-c-fos) were cultured on a stromal cell layer with IL-7. The development was perturbed by the addition of IFN at the beginning of culture. When IFN was added in the FL culture after B lineage cells developed, pro-B (B220+, CD43+) cells were selectively dying by apoptosis within 48 h after IFN stimulation. These results suggest that c-Fos plays a causal role in deletion of pro-B cells.
Hu
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L
Division of Developmental Genetics, Chiba University School of Medicine.
Tokuhisa
T
T
D000818:Animals; D015703:Antigens, CD; D017209:Apoptosis / Q000235:genetics; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D002455:Cell Division; D051917:Leukosialin; D051379:Mice; D016760:Proto-Oncogene Proteins c-fos / Q000502:physiology*; D012795:Sialoglycoproteins; D014157:Transcription Factors
D015703:Antigens, CD; D051917:Leukosialin; D016760:Proto-Oncogene Proteins c-fos; D012795:Sialoglycoproteins; C497863:Spn protein, mouse; D014157:Transcription Factors