Transcriptional repression in development.
It is becoming increasingly clear that transcriptional repression is at least as important as transcriptional activation for establishing cell-type specific patterns of gene expression during embryogenesis. Recent studies in Drosophila suggest that repressors fall into two categories, short-range and long-range repressors. The former permit enhancer autonomy in modular promoters, whereas the latter function in a dominant fashion to silence multiple enhancers.
Gray
S
S
Department of Biology, University of California, San Diego, La Jolla 92093-0347, USA.
Levine
M
M
D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*