[Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine].
Prolactin radioimmunoassay was carried out before and 15, then 30 min after intravenous infusion of protireline (0.2 mg) in 3 groups of male patients: 7 with reactive arthritis (HLA B27: 6; age: 25 +/- 6.3 yr), 13 with ankylosing spondylitis (HLA B27: 11; age: 33.2 +/- 14.7 yr), 5 with psoriatic arthritis (HLA B27: 1; age: 28.8 +/- 6.3 yr). The same test was carried out in sex-age-body mass index matched controls. Only the patients with reactive arthritis presented dynamic hyperprolactinaemia 15 and 30 min after protireline infusion and none of ankylosing or psoriatic arthritis groups. A complete failure of bromocriptine was observed in reactive arthritis. In 2 cases of psoriatic arthritis, adding bromocriptine to gold salts and nonsteroidal anti-inflammatory drug was followed by a drastic efficacy with spectacular improvement in clinical, biological and occupational status. Because none of the cases had hyperprolactinaemia, bromocriptine acted probably had an intrinic anti-inflammatory effect independent of its antiprolactinic effect.
Eulry
F
F
Service de Rhumatologie, Hôpital d'Instruction des Armées Bégin, Saint-Mandé.
Mayaudon
H
H
Bauduceau
B
B
Lechevalier
D
D
Crozes
P
P
Magnin
J
J
Claude-Berthelot
C
C
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000097:blood*; D015535:Arthritis, Psoriatic / Q000097:blood / Q000188:drug therapy; D016918:Arthritis, Reactive / Q000097:blood / Q000188:drug therapy; D001971:Bromocriptine / Q000627:therapeutic use*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D013167:Spondylitis, Ankylosing / Q000097:blood; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D006727:Hormone Antagonists; D001971:Bromocriptine; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin
Prolactinémie sous protiréline (TRH) dans les spondylarthropathies. Tentative de traitement de 4 cas d'arthrite réactionnelle et 2 cas de rhumatisme psoriasique par la bromocriptine.