Neutralising epitopes of simian immunodeficiency virus envelope glycoprotein.
Monoclonal and polyclonal antibodies with weak SIV neutralising activity bind to the V2 and V4 regions of gp120 or bind to the amino acids DWNND in gp41. Antibodies with the most potent neutralising activity recognise conformation-dependent epitopes involving the V3 and V4 regions of gp120. Monoclonal antibodies that map to the V3 region of SIVmac failed to neutralise. However, one antibody to SIV AGM neutralised but only in the presence of soluble CD4.
Kent
K A
KA
National Institute for Biological Standards and Controls, Herts, UK.
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology; D000939:Epitopes; D015686:Gene Products, env / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000276:immunology; D015497:HIV-1 / Q000276:immunology; D008251:Macaca / Q000276:immunology; D009500:Neutralization Tests; D015682:Retroviridae Proteins, Oncogenic / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014760:Viral Fusion Proteins / Q000276:immunology
D015704:CD4 Antigens; D000939:Epitopes; D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D015682:Retroviridae Proteins, Oncogenic; D014760:Viral Fusion Proteins; C059580:transmembrane protein, Simian immunodeficiency virus