The plasma membrane calcium pump--a physiological perspective on its regulation.
This review focuses on the physiological role of the plasma membrane Ca(2+)+ Mg(2+)-dependent adenosine triphosphatase (PM Ca(2+)-ATPase) in cellular signalling. Particular attention has been paid to the regulation of the PM Ca(2+)-ATPase (PM Ca2+ pump) by calmodulin, proteases, protein kinases, acidic phospholipids and oligomerization in intact cells. We also review recent work investigating the possible regulation of the PM Ca2+ pump by G proteins and agonists. The source of adenosine triphosphate (ATP) and Ca2+ in fueling and activating the Ca2+ pump is discussed, as well as the possible role of the PM Ca(2+)-ATPase in subplasma membrane Ca2+ regulation. The physiological implication of the localisation of the PM Ca2+ pump in caveolae is also considered.
Monteith
G R
GR
Department of Pharmacy, University of Sydney, New South Wales, Australia.
Roufogalis
B D
BD
D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology* / Q000648:ultrastructure; D008274:Magnesium / Q000378:metabolism
D000252:Calcium-Transporting ATPases; D008274:Magnesium; D002118:Calcium