The disposition kinetics and residues of fenvalerate in tissues following a single dermal application to black Bengal goats.
The disposition kinetics of fenvalerate were studied in goats after dermal application of 100 ml of 0.25% (w/v) solution. The insecticide persisted in the blood for 72 h. The mean (+/- SEM) Vd(area) and apparent t 1/2 (beta) were 9.92 +/- 1.44 L/kg and 17.51 +/- 2.65 h, while the AUC and ClB values were respectively 82.15 +/- 7.40 micrograms h/ml and 0.56 +/- 0.05 L/(kg h). Four days after the dermal application, the highest concentration of fenvalerate residues was found in the adrenal gland, followed by the biceps muscle, omental fat, liver, kidney, lung and cerebrum in that order. Fenvalerate caused hyperglycaemia but had no effect on serum protein and cholesterol levels. Serum acetylcholinesterase activities were increased after 24 h but were below the initial values from 48 to 120 h.
Mandal
T K
TK
Department of Pharmacology and Toxicology, Bidhan Chandra Krishi Viswavidyalaya, West Bengal, India.
Chakraborty
A K
AK
Bhattacharya
A
A
Ghosh
R K
RK
Majumder
S
S
D000110:Acetylcholinesterase / Q000097:blood; D000279:Administration, Cutaneous; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004350:Drug Residues / Q000493:pharmacokinetics*; D006041:Goats; D006207:Half-Life; D006943:Hyperglycemia / Q000139:chemically induced; D007306:Insecticides / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D007700:Kinetics; D008657:Metabolic Clearance Rate; D009570:Nitriles; D011722:Pyrethrins / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D001798:Blood Proteins; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D002784:Cholesterol; D000110:Acetylcholinesterase; C017690:fenvalerate