title: Serum-sickness-like reaction associated with minocycline therapy in adolescents.
abstract: OBJECTIVE
  To describe a serum-sickness-like reaction in five adolescents treated with minocycline.
  
  
  METHODS
  Five adolescents developed a rash and arthralgias/arthritis after taking minocycline for 10-30 days. Symptoms resolved gradually after the medication was stopped.
  
  
  CONCLUSIONS
  Serum sickness is not described in the pharmacology literature as an adverse effect of minocycline, and in the English literature there are only two case reports. The migration inhibitory factor assay and mast cell degranulation test were positive in four of the five patients. The results of these assays were consistent with a role for minocycline in causing these reactions.
  
  
  CONCLUSIONS
  Clinicians should be aware of the possibility of serum-sickness-like reaction as an adverse effect of minocycline.
authors: Department of Pediatrics C, Children's Medical Center of Israel, Petah Tiqva, Israel.
authors: L
authors: L
authors: Harel
authors: J
authors: J
authors: Amir
authors: E
authors: E
authors: Livni
authors: R
authors: R
authors: Straussberg
authors: I
authors: I
authors: Varsano
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D012713:Serum Sickness / Q000139:chemically induced* / Q000276:immunology
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D008911:Minocycline