title: Activities of nitric oxide in normal physiology and uremia.
abstract: Nitric oxide (NO) generated from arginine exerts a variety of renal and extrarenal physiological and pathophysiological effects. NO is generated by two types of nitric oxide synthases: acutely responsive, constitutive NOS and slower, more persistent inducible NOS (iNOS). The latter is transcriptionally dependent, often stimulated by cytokines. NO regulates glomerular ultrafiltration, tubular reabsorption, and intrarenal renin secretion; many of these renal effects are mediated by interactions with angiotensin II and adrenergic (alpha 2) activity. Decreased NO activity also enhances tubuloglomerular feedback activity, which could contribute to renal vasoconstriction, NaCl retention, and elevated blood pressure. Loss of renal function could influence NO activity via: (1) endothelial dysfunction; (2) decreased arginine synthesis by kidney; (3) responses to arginine analogs that act as NOS inhibitors; (4) increased cytokine activity; and (5) altered oxidation:reduction status of cells, etc. For example, platelet dysfunction in uremia may be caused by cytokine-induced iNOS activation. Moreover, acutely responsive, constitutive NOS activity may be depressed in progressive loss of renal function. Decreased NO activity might contribute to baroreceptor dysfunction observed in hypertension and progressive renal disease. Studies of the impact of uremia suggest that iNOS may be chronically stimulated by cytokines, whereas acutely responsive, constitutive NOS activity may be concurrently depressed.
authors: Department of Medicine, University of California, San Diego School of Medicine, La Jolla, USA.
authors: R C
authors: RC
authors: Blantz
authors: M
authors: M
authors: Lortie
authors: V
authors: V
authors: Vallon
authors: F B
authors: FB
authors: Gabbai
authors: R J
authors: RJ
authors: Parmer
authors: S
authors: S
authors: Thomson
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology; D014511:Uremia / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide