Enhanced gene expression for phosphatidylinositol 3-kinase in the hypoglossal motoneurons following axonal crush.
We attempted to see whether or not gene expression of phosphatidylinositol 3-kinase (PI 3-kinase) is changeable in the hypoglossal nucleus of rats after hypoglossal nerve crushing by in situ hybridization histochemistry. After unilateral nerve crushing, an apparent enhancement of gene expression for PI 3-kinase was observed in individual neurons of the hypoglossal nucleus at the operated side on the first postoperative day, and it was sustained for 7 postoperative days. Thereafter the expression decreased at the operated side and no significant difference in the expression level was noticed between the operated nucleus and the contralateral, non-operated or sham-operated nucleus on postoperative day 14. The present study suggests that PI 3-kinase contributes to some important roles in morphological changes of mature neurons associated with nerve regeneration.
Ito
Y
Y
Department of Anatomy, Tohoku University School of Medicine, Sendai, Japan.
Sakagami
H
H
Kondo
H
H
D000818:Animals; D001369:Axons / Q000502:physiology*; D015870:Gene Expression / Q000235:genetics*; D007002:Hypoglossal Nerve / Q000378:metabolism*; D009046:Motor Neurons / Q000378:metabolism; D009409:Nerve Crush; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D051381:Rats
D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor)