[A mathematical analysis of the relationship of the clinical manifestations of side effects to the blood biochemical indices in subjects undergoing x-ray contrast studies].
During 73 single contrast investigations with 76% triobrast, 76% verographin, 76% urographin, urotrast and omnipaque-300, 65% of patients had clinical adverse reactions which were mainly mild. In 79% of cases, the syndrome of side effects consisted of one clinical manifestation. The occurrence of clinical adverse reactions caused by diatrizoate derivatives was proved to be associated with the elevation of blood levels of histamine and prostaglandin F2 alpha, with the activation of the complement system by an alternative pathway and to be independent of the sex and age of patients. According to the effects of contrast media on these blood biochemical parameters, patients are classified as "tolerant" and "sensitive", the proportion of the latter is 50-80%. With this, plasma histamine levels greater than values of the capacity of the complement system to activate by the alternative pathway greater than blood prostaglandin F2 alpha amounts may serve as mathematically significant criteria for the likelihood of side reactions occurring in the contrast diagnosis with diatriazoates. An elevated diastolic pressure is a valid symptom of side effects of the radioopaque media tested by us on the human body.
Napolov
Iu K
IuK
Napolova
E Iu
EIu
Markina
E V
EV
Krivenko
E V
EV
Sviridov
N K
NK
Shimanovskiĭ
N L
NL
Shimanovskaia
L S
LS
D000293:Adolescent; D000328:Adult; D001769:Blood / Q000187:drug effects* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D003287:Contrast Media; D003973:Diatrizoate
Matematicheskiĭ analiz sviazi klinicheskikh proiavleniĭ pobochnykh reaktsiĭ s nekotorymi biokhimicheskimi pokazateliami krovi liudeĭ pri provedenii rentgenokontrastnykh isledovaniĭ.