title: [Liver cirrhosis and granulomatous hepatitis after prolonged ingestion of lysine acetylsalicylate].
abstract: We report the case of a 75-year-old woman who was hospitalized for serum aminotransferase elevation. She had taken 1 g/d of salicylate therapy (Aspegic 1000) for 5 years, clorazepate for 10 years, naftidrofuryl for 8 months and quinapril for 3 months. Liver histology showed cirrhosis and granulomatous hepatitis. Discontinuation of salicylate therapy resulted in normalization of liver tests, although other drug administration was pursued. This observation suggests that salicylate therapy can induce cirrhosis.
authors: Service d'Hépato-Gastroentérologie, Institut des Maladies de l'Appareil Digestif, Montpellier.
authors: G
authors: G
authors: D'Abrigeon
authors: P
authors: P
authors: Blanc
authors: L
authors: L
authors: Durand
authors: D
authors: D
authors: Larrey
authors: H
authors: H
authors: Michel
mesh_terms: D000368:Aged; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008239:Lysine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012216:Rheumatic Diseases / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000700:Analgesics; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
vernacular_title: Cirrhose et hépatite granulomateuse après la prise prolongée d'acétylsalicylate de lysine.