The effect of high-dose inhaled budesonide on lipid profile in asthmatic patients.
1. We determined the effect of high doses of inhaled corticosteroid (budesonide, BUD, 1600 micrograms/day for 4 weeks) on fasting triglyceride, cholesterol and high-density lipoprotein (HDL)-cholesterol concentration in 11 asthmatic patients. 2. No significant change of serum fasting triglyceride concentrations was found before and after BUD therapy (p > 0.05). However, serum fasting cholesterol concentration decreased slightly (p = 0.03) and HDL-cholesterol concentrations increased after BUD therapy for four weeks (p = 0.01). 3. These results suggest that high-dose BUD therapy does have minor effects on lipid metabolism after long periods of use in asthmatic patients.
Yavuz
O
O
Department of Biochemistry, Gazi University Hospital, Ankara, Turkey.
Türktaş
I
I
Cevik
C
C
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D019819:Budesonide; D005215:Fasting / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D011282:Pregnenediones / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies
D005938:Glucocorticoids; D008055:Lipids; D011282:Pregnenediones; D019819:Budesonide