The effect of cholecystokinin (CCK-33) and C-terminal fragments of cholecystokinin: CCK-8 and CCK-4 on the cardiovascular system in rats.
1. The effects of cholecystokinin (CCK-33) and its fragments CCK-8 and CCK-4 on arterial blood pressure and the function of isolated rat heart and the amount of catecholamines in plasma, heart tissue were studied. 2. The results indicated that shortening of CCK to CCK-8 and CCK-4 eliminates the circulatory effect of this peptide. 3. A correlation was found between the results of in vivo and in vitro experiments and the amount of catecholamines.
Wiśniewska
R J
RJ
Department of Pharmacology, Medical Academy, Białystok, Poland.
Wiśniewski
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D017536:Carotid Artery, Common / Q000187:drug effects; D002395:Catecholamines / Q000096:biosynthesis; D002766:Cholecystokinin / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D015425:Myocardial Reperfusion; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000494:pharmacology*; D013758:Tetragastrin / Q000494:pharmacology*
D002395:Catecholamines; D013758:Tetragastrin; D002766:Cholecystokinin; D012844:Sincalide