title: Drug interactions in transplantation.
abstract: Cyclosporine, tacrolimus, and mycophenolate are selective immunosuppressive agents commonly prescribed to prevent organ rejection. Drug interactions that increase their blood levels could expose transplant recipients to serious side effects, while drug interactions that decrease their blood levels may cause rejection episodes as a result of inadequate immunosuppression. Cyclosporine and tacrolimus are metabolized by the cytochrome P-450 enzyme system. Drugs that induce, inhibit, or compete for the same cytochrome P-450 enzyme could affect blood levels of these immunosuppressive agents.
authors: Bouve College of Pharmacy and Health Sciences, Northeastern University, Boston, Massachusetts, USA.
authors: R
authors: R
authors: Seifeldin
mesh_terms: D016572:Cyclosporine / Q000378:metabolism* / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000145:classification / Q000378:metabolism; D004347:Drug Interactions; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D007527:Isoenzymes / Q000145:classification / Q000378:metabolism; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000493:pharmacokinetics; D016377:Organ Transplantation; D016559:Tacrolimus / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D007166:Immunosuppressive Agents; D007527:Isoenzymes; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; D009173:Mycophenolic Acid; D016559:Tacrolimus