Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for optic nerve glioma in a von Recklinghausen neurofibromatosis patient.
The authors report a unique case of a patient with intraorbital optic nerve glioma and von Recklinghausen neurofibromatosis who developed cerebro-vasculopathy and malignant transformation in the orbit 18 months after radiotherapy treatment. The case is an important reminder of the possibly increased susceptibility of von Recklinghausen neurofibromatosis patients to the complications of radiotherapy.
Jamjoom
A B
AB
Division of Neurosurgery, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Malabarey
T
T
Jamjoom
Z A
ZA
al-Sohaibani
M
M
Hulailah
A
A
Kolawole
T
T
D001921:Brain / Q000098:blood supply; D002343:Carotid Artery, Internal / Q000473:pathology / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects*; D003390:Cranial Nerve Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D009442:Neurilemmoma / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000473:pathology / Q000532:radiotherapy*; D009900:Optic Nerve / Q000473:pathology / Q000528:radiation effects; D009901:Optic Nerve Diseases / Q000473:pathology / Q000532:radiotherapy*; D009915:Orbit / Q000473:pathology / Q000528:radiation effects; D009918:Orbital Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant