Changes in striatal dopamine release in stress-induced conditioned suppression of motility in rats.
Rats received a footshock for 10 min in a chamber with a metallic grid floor, and then placed into the chamber for 30 min after 6 days. The motility of the shocked rats showed a significant decrease (conditioned suppression of motility). In addition, the extracellular dopamine (DA) levels in the striatum were also reduced significantly in in vivo microdialysis study. Thus, dysfunction in the striatal DAergic neuronal systems is responsible for mental stress responses such as conditioned fear stress.
Katoh
A
A
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Nabeshima
T
T
Kuno
A
A
Wada
M
M
Ukai
R
R
Kameyama
T
T
D000818:Animals; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D017551:Microdialysis; D009043:Motor Activity / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000502:physiology
D011954:Receptors, Dopamine; D004298:Dopamine