Superior sagittal sinus thrombosis complicating maintenance treatment for acute lymphoblastic leukemia.
A girl with acute lymphoblastic leukemia in remission had two seizures during the maintenance phase of her treatment. Magnetic resonance imaging with angiography identified a superior sagittal sinus thrombosis as the likely explanation for her symptoms. Possible causes are considered, and previous reports of the neurotoxicity of agents used in the treatment of leukemia are reviewed.
Nicholson
J C
JC
Department of Child Health, Southampton General Hospital, UK.
Darmady
J M
JM
Kohler
J A
JA
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001259:Ataxia; D016543:Central Nervous System Neoplasms / Q000517:prevention & control; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D002542:Intracranial Embolism and Thrombosis / Q000139:chemically induced / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D012640:Seizures; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D011239:Prednisolone; D008727:Methotrexate