title: Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis.
abstract: OBJECTIVE
  To compare qualitative and quantitative magnetic resonance (MR) mammographic features of breast lesions with histopathologic findings, especially tumor angiogenesis.
  
  
  METHODS
  Seventy-three patients (72 women, one man; aged 30-78 years; mean age, 51.0 years) with suspicious breast lesions underwent MR imaging. Noncontrast medium-enhanced localization imaging and then gadolinium-enhanced dynamic fast spoiled gradient-recalled-echo (SPGR) imaging were performed in all patients. In selected patients, subtraction fast SPGR images were obtained. The Pearson and Spearman correlation tests were used to determine the strength of the relationships between enhancement parameters and microvessel determinations.
  
  
  RESULTS
  Time intensity curve type correlated with microvessel density grade (Spearman rank correlation test: r = .90, P < .001). The steepest slope of contrast medium uptake correlated with microvessel counts (Pearson correlation test; r = .83, P < .001). Peripheral enhancement in invasive carcinomas (n = 9) correlated with high peripheral and low central microvessel densities, which were associated with desmoplasia and/or necrosis. Internal septations (n = 2) were seen only in fibroadenomas.
  
  
  CONCLUSIONS
  The density and distribution of microvessels may play major roles in the determination of the initial rate of contrast medium uptake and the heterogeneity of tumor enhancement.
authors: Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors: L D
authors: LD
authors: Buadu
authors: J
authors: J
authors: Murakami
authors: S
authors: S
authors: Murayama
authors: N
authors: N
authors: Hashiguchi
authors: S
authors: S
authors: Sakai
authors: K
authors: K
authors: Masuda
authors: S
authors: S
authors: Toyoshima
authors: S
authors: S
authors: Kuroki
authors: S
authors: S
authors: Ohno
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000098:blood supply* / Q000473:pathology*; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000473:pathology; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA