[Receptor mechanism of dynorphin A in rat secondary spinal cord injuries].
OBJECTIVE
To clarify the effects of dynorphin A on secondary spinal cord injuries.


METHODS
Spinal cord injured rat model made according to modified Allen's method was used by comparing the effect of intrathecal dynorphin A antiserum and that of its receptor antagonist nor-BNI.


RESULTS
The recovery of the muscle tension and motor function of the hindlimb in dynorphin antiserum group was markedly faster than that in both control and nor-BNI groups. Also, the recovery of motor function in the nor-BNI group was favorable at the early stage of injury, compared to the control group. Pathological observation showed that the residual area of the spinal cord in dynorphin A1-13 antiserum group was larger than that in both control and nor-BNI groups. The residual area of the spinal cord in the nor-BNI group was also larger than that in the control group.


CONCLUSIONS
These observations support the hypothesis that dynorphin contributes to certain pathophysiological changes following traumatic SCI through both opiate-receptor mediated and nonopioid mechanisms.
Li
M
M
Department of Orthopedics, Changhai Hospital.
Yang
Y
Y
Hong
X
X
D000818:Animals; D004399:Dynorphins / Q000276:immunology*; D007106:Immune Sera / Q000494:pharmacology*; D007278:Injections, Spinal; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors*; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
D007106:Immune Sera; D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; C051844:norbinaltorphimine; D009271:Naltrexone; C026843:dynorphin (1-13); D004399:Dynorphins