title: The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia.
abstract: Latent inhibition (LI) consists in a retardation of conditioning seen when the to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.
authors: Department of Psychology and MRC Behavioural Neurochemistry Group, Institute of Psychiatry, Denmark Hill, London, UK.
authors: J A
authors: JA
authors: Gray
authors: M H
authors: MH
authors: Joseph
authors: D R
authors: DR
authors: Hemsley
authors: A M
authors: AM
authors: Young
authors: E C
authors: EC
authors: Warburton
authors: P
authors: P
authors: Boulenguez
authors: G A
authors: GA
authors: Grigoryan
authors: S L
authors: SL
authors: Peters
authors: J N
authors: JN
authors: Rawlins
authors: C T
authors: CT
authors: Taib
mesh_terms: D000818:Animals; D001519:Behavior / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008032:Limbic System / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology; D009475:Neurons, Afferent / Q000502:physiology*; D009714:Nucleus Accumbens / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D013216:Reflex, Startle / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*
chemical_list: D004298:Dopamine