Urinary excretion of relaxin after estradiol treatment of postmenopausal women.
The influence of estradiol treatment on the urinary excretion of relaxin, a hormone in earlier years only found during pregnancy and presently associated with functions in the cardiovascular system, was investigated in postmenopausal women. Thirteen postmenopausal women were treated with transdermal estradiol and 12 women with oral estradiol for 4 weeks. A new radioimmunoassay for human-relaxin (rec-hRLX-2) was used. With transdermal, but not with oral administration, a significant increase of urinary relaxin excretion was registered. Further experiments are necessary to elucidate the source of urinary relaxin and its role in the hormone replacement therapy of postmenopausal women.
Lippert
T H
TH
Department of Obstetrics and Gynecology, University of Tuebingen, Germany.
Armbruster
F P
FP
Seeger
H
H
Mueck
A O
AO
Zwirner
M
M
Voelter
W
W
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000652:urine; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology / Q000652:urine*; D012065:Relaxin / Q000652:urine*; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D004967:Estrogens; D004958:Estradiol; D012065:Relaxin