[Clinical observation on effect of yiqi huoxue decoction over the left ventricular diastolic dysfunction].
The left ventricular diastolic function, grade of heart function and degree of Heart-Qi Deficiency of 52 aged patients with left ventricular diastolic dysfunction (LVDD) were measured by means of Doppler echocardiography and left ventricular impedance cardiography before and after treatment with Buqi Qiangxin decoction (BQQXD), a recipe of TCM for reinforcing Qi and promoting blood circulation. The data were compared with that of control group (15 cases) treated with verapamil. Results showed that 92.3% of the LVDD patients were associated with Heart-Qi Deficiency and 69.2% were complicated with blood stasis. After treated with BQQXD, the grade of heart function was elevated in 82.6%, the degree of Heart-Qi Deficiency was improved in 89.6% of the patients. The parameters reflecting the left ventricular diastolic function were all improved in different degree (P < 0.05-0.01), but the parameters reflecting left ventricular compliance were changed insignificantly (P > 0.05). It indicated that besides controlling on the etiological factors, the mechanism of BQQXD in treating left ventricular dysfunction might be related with its calcium antagonistic effect.
Huang
H
H
Jiangxi Institute of TCM, Nanchang.
Tang
Y
Y
Wan
S
S
D000368:Aged; D002307:Cardiography, Impedance / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D018618:Echocardiography, Doppler, Color / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000187:drug effects*
D004365:Drugs, Chinese Herbal