HLA-B27 subtypes among the Chukotka Native groups.
The purpose of this study was to assess the relative frequency of the known HLA-B27 subtypes in HLA-B27 positive Chukotka natives, which have higher frequencies of HLA-B27 (to 40%) and spondyloarthropathies (to 2%) than the Russian Caucasian population. Using oligotyping of the polymerase-chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-B27 positive individuals were successfully typed. All had HLA-B*2705, including 4 patients with Reiter's syndrome and 5 with ankylosing spondyloarthritis, except one Eskimo who had HLA-B*2702. None had HLA-B*2704, a frequent subtype in Orientals. With respect to HLA-B27 subtypes the indigenous populations from the eastern part of the Chukotka Peninsula are genetically more closely related to Caucasians than to Orientalis.
Krylov
M Y
MY
Department of Epidemiology and Genetics of Rheumatic Diseases, Institute of Rheumatology of RAMS, Moscow, Russia.
Reveille
J D
JD
Alexeeva
L I
LI
Erdesz
S
S
Arnett
F C
FC
Benevolenskaya
L I
LI
D000483:Alleles; D001483:Base Sequence; D004247:DNA / Q000032:analysis / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005091:Exons; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012426:Russia; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology
D015796:HLA-B27 Antigen; D004247:DNA