A prospective randomised study of the effect of nicardipine on ischaemic renal injury in renal allografts.
In a prospective double-blind trial, 127 kidneys were randomised to receive Eurocollins (n = 65) or Eurocollins plus nicardipine (n = 62) as a second flush solution at the time of organ retrieval. Delayed graft function occurred in 18 of 65 control kidneys (28%) and in 20 of 62 nicardipine kidneys (32%; P = 0.7, Fischer's exact test). The mean (SD) serum creatinine at 6 weeks was 197 (138) mumol/l in the Eurocollins group and 195 (159) mumol/l in the nicardipine group (P = 0.95). Eighteen recipients (28%) in the controlled Eurocollins group experienced a rejection episode in the first 6 weeks post-transplant compared to 17 (27%) in the nicardipine group (chi 2 with Yates' correction = 0.027; P = > 0.95). In this study, the addition of nicardipine to the kidney perfusion fluid did not have a beneficial effect on kidney function following transplantation.
Nicholson
M L
ML
Department of Surgery, Leicester General Hospital, UK.
Veitch
P S
PS
Bell
P R
PR
D000293:Adolescent; D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D006982:Hypertonic Solutions / Q000009:adverse effects; D007511:Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000293:injuries*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000494:pharmacology*; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D011446:Prospective Studies; D012307:Risk Factors; D014019:Tissue Donors
D002121:Calcium Channel Blockers; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D009529:Nicardipine