title: Use of allopurinol to treat visceral leishmaniosis in a dog.
abstract: Visceral leishmaniosis was diagnosed in a working sled dog on the basis of history, clinical signs, and identification of amastigotes in a skin biopsy specimen. Allopurinol was administered as sole treatment for the disease. The drug was given for 9 months, and, during this time, clinical signs of disease resolved. Laboratory abnormalities had resolved by 12 months after diagnosis and 3 months after treatment. The dog has been without medications for 19 months and remains free of clinical signs, has sired 2 litters, and functions well as lead sled dog for a team.
authors: Central Laboratory for Veterinarians, Langley, British Columbia, Canada.
authors: S J
authors: SJ
authors: Lester
authors: J E
authors: JE
authors: Kenyon
mesh_terms: D000284:Administration, Oral; D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage / Q000627:therapeutic use*; D001707:Biopsy, Needle / Q000662:veterinary; D003080:Cold Temperature; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy*; D004285:Dogs; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D008198:Lymph Nodes / Q000469:parasitology; D008297:Male; D012867:Skin / Q000469:parasitology / Q000473:pathology; D013030:Spain; D015874:Yukon Territory
chemical_list: D000963:Antimetabolites; D000493:Allopurinol