[A basic and clinical evaluation of a new immunoradiometric assay kit for human serum tissue polypeptide antigen (TPA)].
A new immunoradiometric assay kit (IRMA) of human serum tissue polypeptide antigen (TPA) based on combination monoclonal antibodies was evaluated. Using a new TPA-IRMA, the procedure of TPA measurement was faster and the range of measurement was more wide than a conventional TPA-IRMA. 89% (76/85 cases) of patients with malignant tumor and 96.4% (27/28) of patients with metastatic malignant tumor were positively detected. This assay of new TPA-M kit is sensitive to the level of serum TPA which is corresponding to a therapy. It is concluded that a new TPA-IRMA is very useful in monitoring and assessing malignant tumors.
Shimojo
K
K
Division of Diagnostic Nuclear Medicine, Gunma University School of Medicine.
Watanabe
N
N
Sakai
S
S
Kobayashi
M
M
Ohtake
H
H
Hatori
N
N
Fukasawa
K
K
Tomiyoshi
K
K
Inoue
T
T
Endo
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis*; D011933:Reagent Kits, Diagnostic; D019396:Tissue Polypeptide Antigen / Q000097:blood*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D011933:Reagent Kits, Diagnostic; D019396:Tissue Polypeptide Antigen