title: Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery.
abstract: BACKGROUND
  Chondrosarcoma (CS) most commonly involves the pelvis. Local and systemic failures often result in poor outcome. Prognostic factors that determine patient outcome remain ill-defined.
  
  
  METHODS
  We retrospectively analyzed 67 patients with CS of the pelvis treated by definitive surgery from January 1970 to December 1992. All patients had localized disease including Grade 1 (19 patients), Grade 2 (18 patients), Grade 3 (17 patients), and dedifferentiated (13 patients) tumors. Thirty-two patients underwent a limb-sparing surgical resection and 35 patients underwent hemipelvectomy. Follow-up was available for all patients. The median duration of follow-up for the survivors was 115 months (range, 24-288 months).
  
  
  RESULTS
  At last follow-up, 52% of the patients were disease free, 8% were alive with disease, 36% died of disease, and 4% died of other causes. Nineteen patients (28%) had developed a local recurrence (LR). The median time to LR was 23 months (range, 1-111 months). Independent variables in a multivariate analysis associated with increased risk of LR included inadequate surgical margin, tumor epicenter in the pubis, and high grade histology. LR did not influence overall patient survival. Twenty-three patients (36%) developed distant metastases at a median time of 9 months (range, 1-111 months) postoperatively. Metastases developed in 0% of the patients with Grade 1, 20% of the patients with Grade 2 60% of the patients with Grade 3 and 75% of patients with dedifferentiated CS. On multivariate analysis, histologic high grade was the only significant predictive variable for distant relapse (P = 0.005).
  
  
  CONCLUSIONS
  The critical issue for a favorable outcome in low grade CS of the pelvis is adequate surgical excision (i.e., negative surgical margin). The high rate of systemic failure in high grade and dedifferentiated CS, despite adequate surgery, emphasizes the need for more effective systemic therapy.
authors: Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors: D S
authors: DS
authors: Sheth
authors: A W
authors: AW
authors: Yasko
authors: M E
authors: ME
authors: Johnson
authors: A G
authors: AG
authors: Ayala
authors: J A
authors: JA
authors: Murray
authors: M M
authors: MM
authors: Romsdahl
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D002813:Chondrosarcoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D010384:Pelvic Bones / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000556:secondary; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome