[Immunostimulating protein 90K in ovarian carcinoma].
Protein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes. In our in vitro experiences we observed a stimulatory effect by IFN-alpha and IFN-gamma on 90K-specific mRNA expression and protein release in ovarian cancer cells, and 90K was furthermore found to be a potent stimulator of macrophage activity. Protein 90K seems to be involved in tumor immunology; it may represent a critical link between tumor and immune system.
Zeimet
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AG
Universitätsklinik für Frauenheilkunde, Innsbruck.
Marth
C
C
Fuchs
D
D
Herold
M
M
Widschwendter
M
M
Daxenbichler
G
G
Iacobelli
S
S
Dapunt
O
O
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000951:Antigens, Neoplasm / Q000502:physiology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology; D007371:Interferon-gamma / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000276:immunology
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D016898:Interferon-alpha; D007376:Interleukin-2; D009363:Neoplasm Proteins; D012333:RNA, Messenger; C017589:ovarian tumor associated antigen; D007371:Interferon-gamma
Das immunstimulierende Protein 90K beim Ovarialkarzinom.