Platelet responsiveness in migrainous children during headache-free period.
Results of this study confirm the link between migraine and alterations of platelet responsiveness. Our data suggest that in migraineurs the perturbated platelet microviscosity, analyzed by means of fluorescence polarization, appears responsible for the decrease of stimulation-induced influx of external calcium through the platelet membrane. These findings suggest that platelet membrane microviscosity may be considered as a more significant platelet marker of migraine rather than the well-known and nonspecific phenomenon of platelet hyperaggregation, evaluated by time-transmittance variations induced by adenosine diphosphate and collagen.
Tozzi
E
E
Department of Experimental Medicine, University of L'Aquila, Italy.
Tozzi-Ciancarelli
M G
MG
Di Massimo
C
C
Mascioli
A
A
Angelini
R
R
de Matteis
F
F
D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002648:Child; D006801:Humans; D008881:Migraine Disorders / Q000378:metabolism / Q000503:physiopathology*; D010974:Platelet Aggregation
D002118:Calcium