[Severe contact dermatitis caused by mephenesin].
BACKGROUND
Mephenesin is a muscle relaxant, mostly applied locally in trauma. It is a component of Traumalgyl cream in association with phenylbutazone. Contact dermatitis due to mephenesin is exceptional.


METHODS
We report here a case of a woman who developed after application of Traumalgyl cream purpuric dermatitis, erythema multiforme-like and urticarial lesions. Patch-tests were strongly positive (+ + +) for both Traumalgyl cream and mephenesin and (+) for phenylbutazone. Improvement of the lesions was observed within 3 weeks.


CONCLUSIONS
Physicians must be aware of the risk of severe contact dermatitis after application of products including mephenesin because of their widely prescription.
Bachmeyer
C
C
Service de Médecine Interne, Hôpital Hôtel-Dieu, Paris.
Blum
L
L
Fléchet
M L
ML
Duriez
P
P
Cabane
J
J
Imbert
J C
JC
D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D004892:Erythema Multiforme / Q000139:chemically induced; D005260:Female; D006801:Humans; D008615:Mephenesin / Q000009:adverse effects*; D009125:Muscle Relaxants, Central / Q000009:adverse effects*
D009125:Muscle Relaxants, Central; D008615:Mephenesin
Dermite de contact grave à la méphénésine.