title: [Prevention of postoperative nausea and vomiting by lorazepam].
abstract: This study was carried out to assess the efficacy of oral lorazepam on postoperative nausea and vomiting in patients undergoing thyroid surgery. Twenty-six patients were randomly assigned to two groups, and receiving orally, one hour before induction of anaesthesia, either 2.5 mg of lorazepam (n = 13) or a placebo (n = 13). Lorazepam reduced the incidence and especially the intensity of nausea. The incidence of vomiting in the lorazepam group was significantly lower than in the placebo group (14.5% vs 45%). The use of lorazepam for premedication thus reduces the incidence of postoperative nausea and vomiting. The advantages of this benzodiazepine are its ease of use, low cost and very low incidence of side effects.
authors: Departement d'Anesthesie-Réanimation, CHU Averroes, Casablanca, Maroc.
authors: M
authors: M
authors: Laraki
authors: M
authors: M
authors: el Mouknia
authors: A
authors: A
authors: Bouaguad
authors: B
authors: B
authors: Idali
authors: M
authors: M
authors: Benaguida
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use*; D009325:Nausea / Q000517:prevention & control*; D010919:Placebos; D011183:Postoperative Complications / Q000517:prevention & control*; D011229:Preanesthetic Medication; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D014151:Anti-Anxiety Agents; D010919:Placebos; D008140:Lorazepam
vernacular_title: Prévention des nausées et vomissements postopératoires par le lorazépam.