Strategies for cancer gene therapy using adenoviral vectors.
Modification of tumor cells using gene transfer either to enhance host immunity or to act directly on tumor cells is being intensively studied in animal models. Remarkable results have yielded to approved clinical protocols in the treatment of cancer patients using this approach. Several methods of gene delivery have been developed. This article is particularly devoted to the interest of the use of adenoviral vectors in the different strategies of cancer gene therapy.
Descamps
V
V
Génétique des virus oncogènes, Institut Gustave Roussy, Villejuif, France.
Duffour
M T
MT
Mathieu
M C
MC
Fernandez
N
N
Cordier
L
L
Abina
M A
MA
Kremer
E
E
Perricaudet
M
M
Haddada
H
H
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D002986:Clinical Trials as Topic; D005240:Feasibility Studies; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007376:Interleukin-2 / Q000235:genetics / Q000627:therapeutic use; D051379:Mice; D009369:Neoplasms / Q000628:therapy*
D007376:Interleukin-2