Lipoprotein profiles and glucose tolerance in lean and obese chimpanzees.
We compared serum lipid profiles and glucose tolerance of obese and lean chimpanzees maintained on a 10.9% fat diet. Seven of 14 obese and 6 of 17 lean chimpanzees were hypercholesterolemic (low density lipoprotein cholesterol > 160 mg/dl), three obese and three lean animals had total cholesterol/high density lipoprotein cholesterol ratios of 5.9-10.7, and two obese and one lean chimpanzee had abnormal glucose tolerance. Useful numbers of captive chimpanzees thus exhibit metabolic abnormalities without recourse to high fat diets and could serve as surrogates in studies of human metabolic diseases.
Steinetz
B G
BG
Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP), NYU Medical Center, Tuxedo 10987, USA.
Randolph
C
C
Cohn
D
D
Mahoney
C J
CJ
D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000662:veterinary*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000662:veterinary*; D002679:Pan troglodytes; D018419:Primate Diseases; D012016:Reference Values; D012044:Regression Analysis; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol