Topical treatments for hydrofluoric acid dermal burns. Further assessment of efficacy using an experimental piq model.
Several topical treatments for hydrofluoric acid dermal burns (Zephiran, calcium acetate and magnesium hydroxide antacid soaks, and calcium gluconate gel) were assessed for efficacy in a pig model. Gross appearance and histopathology of treated and untreated burn sites were evaluated. For superficial burns, Zephiran was most effective; calcium acetate, magnesium hydroxide antacid, and calcium gluconate gel were less effective. For deep burns, gross observations showed that calcium acetate and Zephiran were most efficacious, whereas histopathology indicated comparable efficacy of Zephiran, calcium acetate, and calcium gluconate gel for all skin layers. Magnesium hydroxide antacid demonstrated efficacy only for the subdermis. The clinically beneficial effects of both Zephiran and calcium gluconate gel were affirmed. Although results suggest that calcium acetate and magnesium-containing antacids may be beneficial for human hydrofluoric acid dermal burns, these are not established clinical treatments.
Dunn
B J
BJ
AlliedSignal Inc., Morristown, New Jersey 07962-1139, USA.
MacKinnon
M A
MA
Knowlden
N F
NF
Billmaier
D J
DJ
Derelanko
M J
MJ
Rusch
G M
GM
Naas
D J
DJ
Dahlgren
R R
RR
D000085:Acetates / Q000008:administration & dosage*; D019342:Acetic Acid; D000287:Administration, Topical; D000818:Animals; D000863:Antacids / Q000008:administration & dosage*; D001548:Benzalkonium Compounds / Q000008:administration & dosage*; D002057:Burns, Chemical / Q000188:drug therapy* / Q000473:pathology; D002125:Calcium Gluconate / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006858:Hydrofluoric Acid; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome
D000085:Acetates; D000863:Antacids; D001548:Benzalkonium Compounds; D003879:Dermatologic Agents; D008276:Magnesium Hydroxide; D019342:Acetic Acid; D006858:Hydrofluoric Acid; D002125:Calcium Gluconate