The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy.
Spontaneous formation of beta-haematin (malaria pigment) from haematin in acetate solution follows pseudo-zero-order and not autocatalytic kinetics. Acetate appears to facilitate the reaction by solubilizing the haematin and acting as a phase-transfer catalyst, a role which, in vivo, could be fulfilled by carboxylic acids or amino acids.
Adams
P A
PA
Department of Chemical Pathology, University of Cape Town, Observatory, South Africa.
Egan
T J
TJ
Ross
D C
DC
Silver
J
J
Marsh
P J
PJ
D000085:Acetates / Q000737:chemistry; D000818:Animals; D006420:Hemeproteins / Q000096:biosynthesis / Q000737:chemistry*; D006427:Hemin / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010860:Pigments, Biological / Q000737:chemistry* / Q000378:metabolism; D010961:Plasmodium / Q000378:metabolism; D015204:Spectroscopy, Mossbauer
D000085:Acetates; D006420:Hemeproteins; D010860:Pigments, Biological; C020753:hemozoin; D006427:Hemin