title: Treatment of mixed cryoglobulinemia with recombinant interferon alpha and adjuvant therapies. A prospective study on 20 patients.
abstract: In order to evaluate the efficacy of interferon alpha (IFNa) in mixed cryoglobulinemia (MC), a prospective multicenter clinical trial was conduced in April 1992. It consisted of treating 20 clinically symptomatic MC patients with IFNa for 26 weeks. Hepatitis C virus (HCV) infection was detected in 16 patients. A complete or partial clinical remission was obtained in 12 patients (60%). Eleven of these 12 responders (91.6%) experienced a clinical relapse less than 12 months after the end of therapy. Side effects were noted in 10 patients (50%). It was concluded that subcutaneously administered IFNa does not provide long-term remission.
authors: Service de Médecine Interne. Hôpital Avicenne, Université Paris-Nord, Bobigny, France.
authors: P
authors: P
authors: Cohen
authors: Q T
authors: QT
authors: Nguyen
authors: P
authors: P
authors: Dény
authors: F
authors: F
authors: Ferrière
authors: D
authors: D
authors: Roulot
authors: O
authors: O
authors: Lortholary
authors: B
authors: B
authors: Jarrousse
authors: F
authors: F
authors: Danon
authors: J H
authors: JH
authors: Barrier
authors: J
authors: J
authors: Ceccaldi
authors: J
authors: J
authors: Constans
authors: B
authors: B
authors: Crickx
authors: J N
authors: JN
authors: Fiessinger
authors: E
authors: E
authors: Hachulla
authors: A
authors: A
authors: Jaccard
authors: M
authors: M
authors: Seligmann
authors: M
authors: M
authors: Kazatchkine
authors: L
authors: L
authors: Laroche
authors: J F
authors: JF
authors: Subra
authors: P
authors: P
authors: Turlure
authors: L
authors: L
authors: Guillevin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003449:Cryoglobulinemia / Q000150:complications / Q000628:therapy*; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000628:therapy; D006801:Humans; D007279:Injections, Subcutaneous; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D011446:Prospective Studies; D011994:Recombinant Proteins; D012008:Recurrence
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents; D007370:Interferon Type I; D011994:Recombinant Proteins