Studies on powder plug formation using a simulated capsule filling machine.
Using an apparatus which simulates the action of a Macofar 13-2 dosating-type capsule-filling machine, the variation in plug weight and density with changing machine parameters has been studied. The piston ejection speed has no effect on plug properties. However increase in compression speed leads to a less consolidated powder plug and hence reduced plug weight. Application of higher pressures reduces plug weight changes, but would be expected to affect release characteristics. Comparison of axial and radial pressures generated by plugs of Starch 1500 and lubricated lactose show significant differences which can be explained by the different consolidation and elastic properties of the two solids.
Britten
J R
JR
Parke-Davis Warner-Lambert, Pontypool, Gwent, UK.
Barnett
M I
MI
Armstrong
N A
NA
D004339:Drug Compounding / Q000295:instrumentation; D007785:Lactose / Q000737:chemistry; D013213:Starch / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*
D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid; D013213:Starch; D007785:Lactose