Effect of USP apparatus 1 and 2 at different rotational speeds on dissolution of niacin formulations.
Forty-four niacin formulations were examined by the United States Pharmacopeia dissolution test, consisting of 0.1N HCl with apparatus 1 and 2. Each formulation was tested with apparatus 1 (basket) at 100 rpm and apparatus 2 (paddle) at 50 and 100 rpm. Dissolution results varied widely among manufacturers.
Kirchhoefer
R D
RD
U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Division of Drug Analysis, St. Louis, MO 63101, USA.
Hamilton
J F
JF
D002214:Capsules; D003692:Delayed-Action Preparations; D006851:Hydrochloric Acid / Q000737:chemistry; D009525:Niacin / Q000737:chemistry*; D010602:Pharmacopoeias as Topic; D011358:Product Surveillance, Postmarketing; D012984:Software; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014481:United States
D002214:Capsules; D003692:Delayed-Action Preparations; D009525:Niacin; D006851:Hydrochloric Acid