Hepatoprotective effects of emodin from Ventilago leiocarpa.
A major component of ethyl acetate (EtOAc) and chloroform (CHCl3) fractions of Ventilago leiocarpa Bunge (Rhamnaceae), emodin, was isolated and exhibited hepatoprotective effects on carbon tetrachloride (CCl4) as well as D-galactosamine (D-GalN)-induced liver damage. The histopathological examination also clearly showed that emodin reduced lymphocyte cells, Kupffer cells, ballooning degeneration, cell necrosis and hyaline degeneration on CCl4 and D-galactosamine-induced tests.
Lin
C C
CC
School of Pharmacy, Kaohsiung Medical College, Taiwan, R.O.C.
Chang
C H
CH
Yang
J J
JJ
Namba
T
T
Hattori
M
M
D000085:Acetates / Q000737:chemistry; D000704:Analysis of Variance; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005591:Chemical Fractionation; D002725:Chloroform / Q000737:chemistry; D004642:Emodin / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005688:Galactosamine / Q000633:toxicity*; D006818:Hyalin / Q000378:metabolism; D007728:Kupffer Cells / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D008297:Male; D009336:Necrosis; D010936:Plant Extracts / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000085:Acetates; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D005688:Galactosamine; C007650:ethyl acetate; D002725:Chloroform; D002251:Carbon Tetrachloride; D004642:Emodin