Role of inflammatory mediators and adhesion molecules in the pathogenesis of aseptic loosening in total hip arthroplasties.
Concentrations of prostaglandin E2, interleukin-6, and interleukin-8 were determined in the hip joint synovial fluid of 20 patients undergoing primary (n = 12) and revision (n = 8) total hip arthroplasties. Levels of soluble adhesion molecules were also investigated in these patients. There was a significant and marked increase in levels of prostaglandin E2 (P < .001), interleukin-6 (P < .011), interleukin-8 (P < .0002), soluble intercellular adhesion molecule 1 (P < .07), soluble vascular adhesion molecule 1 (P < .0006), and soluble endothelial leukocyte adhesion molecule 1 (P < .0003) in joint fluid of patients undergoing revision. On the basis of these observations, it is suggested that synovial fluid and its inflammatory contents could play a significant role in the pathogenesis of aseptic loosening in total hip arthroplasties.
Sabokbar
A
A
Orthopaedic Research Unit, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Rushton
N
N
D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology; D016209:Interleukin-8 / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology*; D011475:Prosthesis Failure; D012016:Reference Values; D012086:Reoperation; D013582:Synovial Fluid / Q000502:physiology
D015815:Cell Adhesion Molecules; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D015232:Dinoprostone