Effects of enalapril on tissue factor in patients with uncomplicated acute myocardial infarction.
In a randomized, double-blind, placebo-controlled study beginning 4 weeks after uncomplicated acute myocardial infarction, it was established that the baseline plasma tissue factor antigen level was significantly higher in patients with myocardial infarction than in control subjects, and enalapril therapy significantly reduced the elevated plasma tissue factor antigen level. This may be associated with the reduction in the risk of coronary thrombosis seen with the use of angiotensin-converting enzyme inhibitors.
Soejima
H
H
Division of Cardiology, Kumamoto University School of Medicine, Japan.
Ogawa
H
H
Yasue
H
H
Suefuji
H
H
Kaikita
K
K
Tsuji
I
I
Kumeda
K
K
Aoyama
N
N
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000187:drug effects; D013925:Thromboplastin / Q000032:analysis / Q000187:drug effects*; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D013925:Thromboplastin; D007703:Peptidyl-Dipeptidase A