title: A comparison of equid herpesvirus-1 (EHV-1) vascular lesions in the early versus late pregnant equine uterus.
abstract: Four Welsh Mountain pony mares at 3 months of gestation and one mare at 5 months were inoculated intranasally with equid herpesvirus-1 (EHV-1: Ab4 isolate) at doses of 10(5) to 10(6.6) TCID50. All five mares became infected, but no cases of paresis or abortion occurred. On days 8, 9, 11, 12 (3-month-pregnant mares) and 13 (5-month-pregnant mare) after infection, a detailed examination of the pregnant uterus was made. Small numbers of vascular lesions with EHV-1 antigen expression in endothelial cells were present in the uteri of the early gestational mares; thrombi were rare and foci of thromboischaemic damage were not seen. Six pony mares previously inoculated with EHV-1 Ab4 at 9 months of gestation had a significantly greater degree of vascular abnormality than that found in the four mares infected at 3 months of gestation, but the degree of EHV-1 antigen expression and thrombosis in the uterus was similar to that found in the single mare infected when 5 months pregnant.
authors: Animal Health Trust, Centre for Preventive Medicine, Suffolk, UK.
authors: K C
authors: KC
authors: Smith
authors: J A
authors: JA
authors: Mumford
authors: K
authors: K
authors: Lakhani
mesh_terms: D000034:Abortion, Veterinary / Q000209:etiology / Q000473:pathology* / Q000821:virology; D000281:Administration, Intranasal; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001160:Arterioles / Q000473:pathology; D002824:Chorionic Villi / Q000473:pathology / Q000821:virology; D005260:Female; D005865:Gestational Age; D006566:Herpesviridae Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D004861:Herpesvirus 1, Equid / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D006734:Horse Diseases / Q000473:pathology* / Q000821:virology; D006736:Horses / Q000821:virology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000662:veterinary*; D011782:Quadriplegia / Q000662:veterinary / Q000821:virology; D012141:Respiratory Tract Infections / Q000473:pathology / Q000662:veterinary / Q000821:virology; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary / Q000821:virology; D014599:Uterus / Q000098:blood supply* / Q000473:pathology; D014652:Vascular Diseases / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral