Preovulatory overripeness of the oocyte as a cause of ovarian dysfunction in the human female.
A variety of gynaecological phenomena such as menstrual disorders, infertility and premature menopause are associated with ovarian dysfunction. In this paper, a factor is considered that may play a role in the aetiology of ovarian dysfunction. Animal research has shown that preovulatory overripeness of the oocyte may cause various developmental and chromosomal anomalies. Among the developmental anomalies observed in amphibia and fish are a number of gonadal aberrations, often occurring in otherwise normal specimens. This may be the consequence of a degeneration of the 'germinal cytoplasm', cytoplasmic structures located in the vegetative pole region of the oocyte, destined to become part of future primordial germ cells. Indirect evidence suggests that preovulatory overripeness of the oocyte also plays a significant role in human reproductive failure. An increased risk of preovulatory overripeness is expected during periods of endocrine irregularities, such as the first postmenarcheal years, the last premenopausal years, the first months after a pregnancy and, possibly, during certain seasons. If the overripeness-induced gonadal maldevelopment observed in animals also occurs in humans, this may explain variations in reproductive function according to month of birth, as observed in women. It is hypothesized that females conceived during periods of maternal endocrine irregularities face an increased risk of ovarian dysfunction through overripeness-induced gonadal maldevelopment.
Smits
L J
LJ
Department of Medical Informatics, Epidemiology and Statistics, University of Nijmegen, The netherlands.
Jongbloet
P H
PH
Zielhuis
G A
GA
D000663:Amphibians; D000818:Animals; D005260:Female; D005399:Fishes; D006801:Humans; D008954:Models, Biological; D009865:Oocytes / Q000254:growth & development*; D010049:Ovarian Diseases / Q000209:etiology*; D010053:Ovary / Q000002:abnormalities / Q000254:growth & development; D010060:Ovulation; D011247:Pregnancy; D012621:Seasons