Circulating immune complexes in intracranial neoplasms.
The levels of circulating immune complexes (CIC) were assayed in the sera of 109 patients with intracranial space occupying lesions. The CIC levels were significantly increased in all the brain tumours. After treatment, the CIC levels were still significantly increased when compared to the controls but showed no change when compared to their respective pre-operative values. Further, no change was observed in the CIC levels between the malignant and benign tumour case. Moreover, in brain tumours, 90% of the CIC precipitate consisted of IgG. However, the CIC levels fail to prognosticate the process of the disease in these patients.
Manjula
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S
Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India.
Aroor
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Raja
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Rao
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood*; D000951:Antigens, Neoplasm / Q000097:blood; D001932:Brain Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008579:Meningioma / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant
D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D007074:Immunoglobulin G; D007075:Immunoglobulin M