title: Resolution of dysarthria in multiple sclerosis by treatment with weak electromagnetic fields.
abstract: It has been reported that 50% or more of patients diagnosed with multiple sclerosis (MS) exhibit speech impairment (dysarthria) which in some cases can be exceedingly disabling. Currently there is no effective medical treatment for the dysarthria of MS which occurs as a result of lesions to the cerebellum and its outflow tracts. It was reported recently that extracranial application of brief AC pulsed electromagnetic fields (EMFs) in the picotesla (pT) range intensity produced in patients with MS sustained improvement in motor functions including cerebellar symptomatology. This communication concerns two MS patients with a chronic progressive course who exhibited severe dysarthria which improved already during the initial treatment with pulsed EMFs and which resolved completely 3-4 weeks later. Since application of EMFs has been shown to alter: (a) the resting membrane potential and synaptic neurotransmitter release through an effect involving changes in transmembrane calcium flux; and (b) the secretion of pineal melatonin which in turn influences the synthesis and release of serotonin (5-HT) and gamma-amino butyric acid (GABA) in the cerebellum, it is suggested that the immediate improvement of the dysarthria occurred as a result of changes in cerebellar neurotransmitter functions particularly 5-HT and GABA rather than from remyelination.
authors: NeuroCommunication Research Laboratories, Danbury, CT 06811, USA.
authors: R
authors: R
authors: Sandyk
mesh_terms: D001921:Brain / Q000503:physiopathology; D004401:Dysarthria / Q000209:etiology* / Q000628:therapy*; D004574:Electromagnetic Fields; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D008550:Melatonin / Q000378:metabolism; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D010870:Pineal Gland / Q000378:metabolism; D012701:Serotonin / Q000096:biosynthesis; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
chemical_list: D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D008550:Melatonin