[Pulmonary involvement of collagen vascular diseases: studies on prognostic factors from basic and clinical viewpoints].
In 715 patients with collagen vascular diseases, interstitial lung disease and pulmonary hypertension were found to be important causes of death (37.5% and 6%, respectively). The prognosis of interstitial lung disease associated with collagen vascular disease was better than that of idiopathic interstitial pneumonia; patients with the latter were more likely to experience exacerbations. A distinct subgroup of patients with dermatomyositis and interstitial lung disease with a rapidly progressive course was characterized by mild muscle symptoms, low levels of creatine phosphokinase and negative tests for anti-Jo-1 antibody. CT scores and analysis of bronchoalveolar lavage fluid proved to be of some value in predicting outcome. Measurement of IL-6 in bronchoalveolar lavage fluid and local immunostaining for this pro-inflammatory cytokine were helpful in evaluating responses to therapy.
Takizawa
H
H
Department of Internal Medicine Therapy, University School of Medicine, Hamamatsu, Japan.
Suzuki
N
N
Yanagawa
T
T
Okazaki
H
H
Satoh
M
M
Akiyama
N
N
Kohyama
T
T
Ito
K
K
Oka
T
T
Hayakawa
K
K
D000974:Antibodies, Antinuclear / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016516:CD4-CD8 Ratio; D003095:Collagen Diseases / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000503:physiopathology*; D011379:Prognosis; D014057:Tomography, X-Ray Computed
D000974:Antibodies, Antinuclear; D015850:Interleukin-6; C046750:Jo-1 antibody