[Role of blood-brain barrier disorders in the pathogenesis of alcoholic heart damage].
An experimental study of alcoholic heart damage was performed in 150 male rats of series I, II and III with modelled acute alcoholic intoxication, chronic alcoholic intoxication against developing abstinence syndrome, alcoholic abstinence syndrome, respectively. The degree of cardiomyocyte damage is largely determined by structural changes of histohematic barriers in alcoholic intoxication. Primary ethanol damage of the microcirculatory bed, that of perivascular connective tissue and sarcolemma result in a cardiomyocyte mitochondria damage and development of energetic deficiency. Atrophic and sclerotic alterations of the histohematic barrier develop in chronic alcoholic intoxication resulting in profound metabolic changes in the heart muscle and development of alcoholic cardiomyopathy. The damages to the histohematic barrier in abstinence syndrome result in catecholamine penetration into cardiomyocytes and development of focal necrosis in the myocardium.
Zavitaeva
I B
IB
Research Center of Drug Control, Medical Academy, Moscow, Russia.
Beliaeva
N Iu
NIu
Paukov
V S
VS
D000435:Alcoholic Intoxication / Q000150:complications; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002310:Cardiomyopathy, Alcoholic / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000648:ultrastructure; D004734:Energy Metabolism / Q000502:physiology; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects / Q000648:ultrastructure; D009336:Necrosis; D051381:Rats
Rol' narushenĭ i gistogematicheskikh bar'erov v patogeneze alkogol'nogo povrezhdeniia serdtsa.