[Morphofunctional features of fibroblasts in wound healing in old age].
Fibroblastic reaction in the course of posttraumatic repair of the skin in old rats is weaker and proceeds more slowly, the foci of active fibroblast proliferation are observed. The reduction of the fibroblast number in the wound in old rats is followed by an increase in their functional activity which, however, does not compensate for their quantitative decrease. Fibroblasts of old rats considerably vary in their structure and age-associated changes in their synthetic function are followed by disturbance of the secretory function. Intracellular development of collagen fibrils may occur under these conditions.
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Medical University, Kiev, Ukraine.
D000375:Aging / Q000473:pathology*; D000818:Animals; D002455:Cell Division / Q000502:physiology; D005347:Fibroblasts / Q000473:pathology; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000502:physiology*
Nekotorye morfofunktsional'nye osobennosti fibroblastov pri zazhivlenii ran v starosti.