Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: an early event in seven-transmembrane receptor mediated signaling.
Gonadotropin releasing hormone (GnRH) mediates interactions between the neural and the endocrine systems. The GnRH receptor is a member of the ubiquitous seven-transmembrane segment G-protein-coupled receptor class and is the target of drug development for treatment of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses. This study shows that occupancy of the receptor by an agonist (but not an antagonist) promotes receptor-receptor interactions which appears to be an early event in hormone action.
Janovick
J A
JA
Oregon Regional Primate Research Center, Division of Neuroscience, Beaverton 97006, USA.
Conn
P M
PM
D000818:Animals; D002417:Cattle; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000494:pharmacology; D007784:Lactoperoxidase / Q000494:pharmacology; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011966:Receptors, LHRH / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D007784:Lactoperoxidase