Effect of surgically induced hypoestrinism on immunoregulation in perimenopausal women.
The object of the present study was to investigate the effect of bilateral oophorectomy (OOX) on CD4+ and CD8+ subsets of T-lymphocytes in 8 immunologically healthy perimenopausal women with regular bleeding. Between the 12th and 16th week after OOX, CD8+ (%) increased in all of the investigated women (mean values compared to values before OOX: 37.8 +/- 3.4 vs 26 +/- 4.13, p < 0.05). CD4+ increased in five women, and decreased in another three (means: 36.4 +/- 3.6 vs 38 +/- 4.6). The immunoregulatory index (CD4+/CD8+ ratio) declined in seven women, while it was unchanged in one (means: 1.09 +/- 0.2 vs 1.71 +/- 0.22, p < 0.05). The compliance of the treatment was controlled by serum estrogen, LH and FSH. From these results it is apparent that surgically induced hypoestrinism inhibits immunoregulation in perimenopausal women.
Zofková
I
I
Institute of Endocrinology, Prague, Czech Republic.
Kancheva
R L
RL
D000328:Adult; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000097:blood / Q000502:physiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000276:immunology*; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*
D017252:CD3 Complex; D004967:Estrogens; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone