Anions, membrane resistance and ventricular fibrillation.
Clinical success in prevention of sudden cardiac death has been poor. New approaches to prevention of ventricular fibrillation (VF), one of the main causes of sudden cardiac death, are clearly needed. In the present article we have reviewed some of our own data which support the notion that VF may be prevented by manipulation of chloride homeostasis. Our studies have revealed a novel approach to VF suppression via alteration of sarcolemmal membrane resistance.
Curtis
M J
MJ
Cardiovascular Research Laboratories, King's College University of London, UK.
Ridley
P D
PD
D000818:Animals; D002463:Cell Membrane Permeability / Q000502:physiology; D002712:Chlorides / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D006706:Homeostasis; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015425:Myocardial Reperfusion; D009566:Nitrates / Q000378:metabolism; D051381:Rats; D012508:Sarcolemma / Q000502:physiology; D014693:Ventricular Fibrillation / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control*
D002712:Chlorides; D009566:Nitrates; D000242:Cyclic AMP; D006152:Cyclic GMP