[Thyroid function in smelters after long-term exposure to heavy metals].
In the year 1995 in a group of 93 male workers of a copper smelter (mean age = 40,7 years, exposure time = 8,5 years) following parameters were measured: blood levels of: lead and cadmium; serum levels of copper, zinc, calcium and magnesium-with use of atomic absorption spectrophotometry; FEP-with Piomelli's method; and T3, T4 and TSH in serum with radioimmunometric method. Mean blood lead level was 38,2 micrograms/dl, and concentrations of other metals and hormones were within norm limits. Mean level of FEP was slightly above norm (FEP = 106,5 micrograms/100 ml E). We found no correlation between investigated hormones (T3, T4 and TSH) and age, length of exposure nor blood lead level. We found a significant inverse correlation between FEP and TSH (r = -0,207; p < 0,047). This correlation could point to the fact that lead burden (expressed not in the actual blood level but in the FEP concentration) could negatively influence endocrine functions through hypothalamic-pituitary axis.
Andrzejak
R
R
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych Akademii Medycznej we Wrocławiu.
Antonowicz
J
J
Bolanowska
B
B
Hebdziński
L
L
Kabacińska-Knapik
D
D
Smolik
R
R
D000328:Adult; D003300:Copper / Q000009:adverse effects*; D004784:Environmental Monitoring; D006801:Humans; D008297:Male; D008669:Metallurgy; D008670:Metals / Q000097:blood; D016273:Occupational Exposure; D011524:Protoporphyrins / Q000097:blood; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood*
D008670:Metals; D011524:Protoporphyrins; D003300:Copper; D013972:Thyrotropin
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