Effect of the insect growth regulators, N-tert-butyl-N, N'-dibenzoylhydrazines, on neural activity of the American cockroach.
N-tert-Butyl-N,N'-dibenzoylhydrazines, agonists of 20-hydroxyecdysone, decelerated the rising and falling phases of an action potential, which had been electrically induced in the cockroach giant axon, at moderately high concentrations. 4-Aminopyridine, a blocker of potassium channels of nerve, selectively decelerated the falling phase of the action potential. This class of compounds caused convulsions in American cockroaches when injected. The convulsive activity seemed to be positively related to the activity to decelerate the falling phase of the action potential.
Nishimura
K
K
Research Institute for advanced science and technology, Osaka Prefecture University, Japan.
Tada
T
T
Nakagawa
Y
Y
D015761:4-Aminopyridine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000187:drug effects; D003058:Cockroaches / Q000502:physiology*; D006834:Hydrazines / Q000494:pharmacology*; D007313:Insecta / Q000502:physiology*; D007306:Insecticides / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced
D006834:Hydrazines; D007306:Insecticides; D007605:Juvenile Hormones; D015221:Potassium Channels; C056565:1,2-dibenzoyl-tert-butylhydrazine; D015761:4-Aminopyridine