Observations on the decay of glycated hemoglobin HbA1c in diabetic patients.
In 44 diabetic patients, who within 7 days lowered their average glycemia by 140 to 220 mg % and kept it at this level over a mean of 36 days, HbA1c was measured repeatedly by HPLC (normal range 4.2-5.6% of total hemoglobin). Thereby, the maximum decay rate of HbA1c could be observed in vivo as being 0.1% per day which is consistent with previous theoretical considerations by other authors. Some clinical implications that this finding may have for diabetic patients are being discussed.
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Department of Metabolic Diseases and Nutrition, Heinrich-Heine-University of Düsseldorf/Germany.
D001786:Blood Glucose / Q000378:metabolism*; D015190:Blood Glucose Self-Monitoring; D002851:Chromatography, High Pressure Liquid; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D012016:Reference Values; D012044:Regression Analysis; D013997:Time Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin