[Aspergillus fumigatus: from saprophytism to virulence. Phenotypic and genotypic biodiversity].
During the last two decades, deep changes have arised in aspergillosis. Thus, this fungal infection mainly due Aspergillus fumigatus is becoming a serious public health-hazard in the growing population of immunocompromised patients. From literature and their own experience, the authors present a synthesis of phenomenons promoting this evolution: the host predisposing factors, environment and potential contamination sources, then the fungus itself. Genetic research developed into the disease-causing organism could be of major interest in epidemiology of aspergillosis and to identify new targets of prophylaxis.
Grillot
R
R
Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS EP 78, Université Joseph-Fourier Grenoble I, La Tronche.
Mondon
P
P
Brenier
M P
MP
Ambroise-Thomas
P
P
D001228:Aspergillosis / Q000145:classification / Q000276:immunology; D001232:Aspergillus fumigatus / Q000235:genetics* / Q000472:pathogenicity*; D017753:Ecosystem; D005838:Genotype; D006801:Humans; D016867:Immunocompromised Host; D010641:Phenotype; D014774:Virulence
Aspergillus fumigatus: du saprophytisme à la virulence. Biodiversité phénotypique et génotypique.