Extraction and quantitation of digoxin and acetyldigoxin from the Digitalis lanata leaf via near-supercritical methanol-modified carbon dioxide.
An extraction process is reported that employs a near-supercritical mixture of CO2 and MeOH to extract the cardiac glycoside, digoxin, from the Digitalis lanata leaf. The method development of the sample preparation procedure is presented in detail, and reasons for trends that occur in the natural products extraction are given.
Moore
W N
WN
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
Taylor
L T
LT
D000113:Acetyldigoxins / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004070:Digitalis / Q000737:chemistry*; D004077:Digoxin / Q000032:analysis* / Q000302:isolation & purification; D006868:Hydrolysis; D010936:Plant Extracts / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal; D010947:Plants, Toxic
D000113:Acetyldigoxins; D010936:Plant Extracts; D004077:Digoxin