title: Quorum sensing: a population-density component in the determination of bacterial phenotype.
abstract: In bacteria, a network of cellular transduction mechanisms integrate signals from the bacterial environment to control gene expression, and thereby the bacterial phenotype. 'Quorum sensing' describes one such signalling mechanism in response to population density. It relies on the accumulation of small extracellular signalling molecules to modulate the transcription of target operons.
authors: Department of Applied Biochemistry and Food Science, University of Nottingham, Leicestershire, UK.
authors: S
authors: S
authors: Swift
authors: J P
authors: JP
authors: Throup
authors: P
authors: P
authors: Williams
authors: G P
authors: GP
authors: Salmond
authors: G S
authors: GS
authors: Stewart
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003227:Conjugation, Genetic / Q000502:physiology; D004798:Enzymes / Q000096:biosynthesis; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D006714:Homoserine / Q000031:analogs & derivatives; D007783:Lactones / Q000494:pharmacology; D008163:Luminescent Measurements; D008954:Models, Biological; D015394:Molecular Structure; D010641:Phenotype; D010675:Pheromones / Q000494:pharmacology*; D012097:Repressor Proteins; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004798:Enzymes; D007783:Lactones; C085427:LuxI protein, Bacteria; D010675:Pheromones; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C064778:LuxR autoinducer binding proteins; D006714:Homoserine