Prophylactic treatment of migraine: evaluation of clinical trials and choice among drugs.
A checklist is presented to assist with the evaluation of a controlled trial in migraine prophylaxis. The following points are discussed briefly: aim of the study, design of the study, efficacy parameters, and presentation of results and statistics. Choice among drugs for migraine prophylaxis is described taking into account: clinical efficacy, scientific proof for efficacy, and contraindications.
Tfelt-Hansen
P
P
Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D000075202:Contraindications; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal