[Dermatotoxicity studies of calcipotriol (MC903) ointment--primary skin irritation, skin sensitization, phototoxicity and skin photosensitization].
MC903 ointment was studied on primary skin irritation in rabbits and skin sensitization, skin photosensitization and phototoxicity in guinea-pigs. 1. MC903 ointment, ointment base and deteriorated MC903 ointment induced erythematous changes in rabbit skin. These erythematous changes were not so serious, and they were classified as a mild irritant. 2. MC903 ointment was almost negative in skin sensitization study. 3. MC903 ointment has no skin phototoxicity in guinea-pigs. 4. MC903 ointment has no skin photosensitizing activity in guinea-pigs.
Suzuki
T
T
Japan Seigiken Research Center Co., Ltd., Shizuoka, Japan.
Kato
T
T
Kitagaki
T
T
Ono
M
M
Shirakawa
K
K
Nagata
M
M
Konishi
R
R
D000818:Animals; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000633:toxicity*; D004890:Erythema / Q000139:chemically induced; D006168:Guinea Pigs; D007114:Immunization; D007509:Irritants / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009824:Ointments; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology
D003879:Dermatologic Agents; D007509:Irritants; D009824:Ointments; C055085:calcipotriene; D002117:Calcitriol