[Apoptosis related gene, Pim-1].
Pim-1, a protooncogene product, induced tumor in the combination with MYC. So far, two reports were published concerning Pim-1 function to apoptosis. One was that Pim-1 inhibit apoptosis in Pim-1 introduced transgenic mouse with a background of lpr/lpr, in which Fas was abrogated. However, the other that Pim-1 induced apoptosis in a transient expression system was also reported. In this communication, we survey the possible functions of Pim-1 in terms of the factor related to apoptosis and carcinogenesis.
Ariga
H
H
Faculty of Pharmaceutical Sciences, College of Medical Technology, Hokkaido University.
Iguchi-Ariga
S M
SM
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology; D051573:Proto-Oncogene Proteins c-pim-1; D015398:Signal Transduction
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; C496636:Pim1 protein, mouse; D017346:Protein Serine-Threonine Kinases; D051573:Proto-Oncogene Proteins c-pim-1