Neuroimmunological aspects of fetus and newborn brain damage in complicated pregnancy.
OBJECTIVE
The role of neuroautoimmune mechanisms in pathogenesis of perinatal damage of fetus and neonate brain during complicated pregnancy is considered to be important.


METHODS
To determine neurospecific antigens (NSA) and their antibodies, ELISA and two-site column enzyme immunoassay were used.


RESULTS
The contents of NSA and anti-brain antibodies, associated with fetal brain congenital development defects, account for the development of neuroautoimmune shifts in the mother-fetus system. The time of NSA appearance in serum from pregnant women, the dynamics of their level during pregnancy, and the appearance of anti-brain antibodies were determined, not by the nosology of extragenital pathology, but by the degree of fetus suffering, i.e., by the state of its central nervous system, connected with the decompensation of metabolic processes and homeostatic disorder in a mother-fetus system.


CONCLUSIONS
Approved immunodiagnostic test systems should be recommended as markers for determination of pregnancy risk group, prognosticating perinatal pathology of neonatal and childhood CNS disorders.
Borodin
Y
Y
Department of Obstetrics and Gynecology, Kazan Medical University, Russia.
Chekhonin
V
V
D001921:Brain / Q000276:immunology* / Q000473:pathology*; D005314:Embryonic and Fetal Development / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood; D006801:Humans; D015213:Neuroimmunomodulation; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000473:pathology*; D011257:Pregnancy Proteins / Q000032:analysis; D018566:Pregnancy, High-Risk / Q000276:immunology
D005904:Glial Fibrillary Acidic Protein; D011257:Pregnancy Proteins; D010751:Phosphopyruvate Hydratase