title: [Side effects of influenza vaccination in patients over 60 years of age].
abstract: The purpose of this study was to investigate the various factors affecting the incidence of adverse reactions after influenza immunization with either a subunit or an inactivated whole-virus vaccine. A total of 1,959 nursing home residents in Geneva (mean age: 84 +/- 8 years, sex ratio: 3F/1M) were randomly allocated to the two vaccine groups. Results showed that the incidence of local adverse reactions could be reduced by using the subunit vaccine injected into the buttock or the internal aspect of the thigh, in preference to the deltoid muscle. Moreover, this study demonstrated that intramuscular injection lowers the risk of local reactions but tends to increase the incidence of general reactions. Implementation of these recommendations should reduce the frequency of side effects due to influenza vaccination and, consequently, raise the rate of acceptance and the immunization coverage of the populations exposed to risk.
authors: Institutions Universitaires de Gériatrie, Genève, Suisse.
authors: L
authors: L
authors: Gauthey
authors: R
authors: R
authors: Martin
authors: F
authors: F
authors: Herrmann
authors: J
authors: J
authors: Karsegard
authors: J P
authors: JP
authors: Michel
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006760:Hospitalization; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013557:Switzerland
chemical_list: D007252:Influenza Vaccines
vernacular_title: Effets secondaires de la vaccination antigrippale chez les personnes âgées de plus de 60 ans.