[Correlation between ability of learning-memory and synaptosomal free [Ca2+]i in mice of different age].
In the present investigation, the behavior of learning and memory of 1-month and 6-month-old mice was studied by using Y-maze and one-trial passive avoidance response device. The synaptosomal free [Ca2+]i of four main brain regions (Hippocampus, Cerebral cortex, Cerebellum, Tectum of midbrain) of these mice were measured by fluorescent probe Ca2+ indicator Fura-2 and an AR-CM-MIC cation measurement system. The results showed that, in comparison with 1-month-old mice, the ability of discrimination learning and memory of 6-month-old ones were attenuated, and the synaptosomal free [Ca2+]i of hippocampus was increased.
Du
H Y
HY
Department of Biological Science and Technology, Nanjing University.
Zhang
W N
WN
Zhang
Z G
ZG
Shao
Y
Y
Wang
L B
LB
Wang
J X
JX
Wu
F M
FM
D000367:Age Factors; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D004193:Discrimination Learning / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D051379:Mice; D012153:Retention, Psychology / Q000502:physiology*; D013574:Synaptosomes / Q000378:metabolism
D002118:Calcium