Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis.
The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) were determined by double determinant immunoassay (DDIA), in 37 patients with atopic dermatitis (AD) and 31 age- and sex-matched healthy control subjects. Both sICAM-1 and sE-selectin levels were significantly higher in patients with AD than in healthy controls (P < 0.01), and were correlated with disease severity. A longitudinal study of patients with AD revealed that the levels of sICAM-1 decreased in those in whom symptoms improved. The sICAM-1 levels were significantly correlated with those of sE-selectin. Our studies suggest that such high levels of serum sICAM-1 and sE-selectin may affect the immune response in patients with AD. The levels of sICAM-1 and sE-selectin may be a useful immunological parameter for monitoring disease activity in AD.
Hirai
S
S
Department of Dermatology, Kumamoto University School of Medicine, Japan.
Kageshita
T
T
Kimura
T
T
Tsujisaki
M
M
Okajima
K
K
Imai
K
K
Ono
T
T
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D012720:Severity of Illness Index
D015415:Biomarkers; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1