[RP105 and B cell apoptosis].
The RP105 is a novel, murine B cell surface molecule that is expressed on mature B cells but not on pre-B or T cells. The RP105 is a 150 kDa type I transmembrane protein, and a member of the leucine-rich repeat protein family. Tandem repeats of a leucine-rich motif in the extracellular domain are thought to be involved in processes such as cell adhesion or receptor-ligand interactions. An antibody against RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis, and drives them to proliferate. B cells activated by RP105-ligation arrest their growth and undergo apoptosis when the antigen receptor is engaged. Thus, RP105 is a signal transduction molecule and seems to have a role in regulation of B cell growth and death.
Miura
Y
Y
Department of Immunology, Saga Medical School.
Yamashita
Y
Y
Miyake
K
K
D000818:Animals; D015703:Antigens, CD; D017209:Apoptosis; D001402:B-Lymphocytes; D003001:Cloning, Molecular; D006801:Humans; D007075:Immunoglobulin M; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
D015703:Antigens, CD; C092722:CD180 protein, human; D007075:Immunoglobulin M; D008565:Membrane Proteins