[Hypomagnesemic and hypocalcemic coma, convulsions and ocular motility disorders after chemotherapy with platinum compounds].
We describe a case of neurologic manifestations including coma, convulsion and eye movement disorders, associated with hypomagnesemia and hypocalcemia in a patient treated with cisplatin for an ovarian adenocarcinoma. Pathophysiological mechanisms involve renal tubular damage leading to renal magnesium wasting and related hypocalcemia.
Bachmeyer
C
C
Service de médecine interne, hôpital Hôtel-Dieu, Paris, France.
Decroix
Y
Y
Médioni
J
J
Dhôte
R
R
Benfiguig
K
K
Houillier
P
P
Grateau
G
G
D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced*; D008274:Magnesium / Q000097:blood*; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced
D000970:Antineoplastic Agents; D016190:Carboplatin; D008274:Magnesium; D002945:Cisplatin
Coma, crise convulsive et troubles de l'oculomotricité hypomagnésémiques et hypocalcémiques après chimiothérapie par sels de platine.