Triggering of ovulation by a gonadotropin-releasing hormone (GnRH) agonist in patients pretreated with a GnRH antagonist.
OBJECTIVE
To determine if GnRH-agonist (GnRH-a) could induce a LH surge in patients where a GnRH antagonist was used to prevent premature spontaneous LH surge.


METHODS
Pilot study.


METHODS
Five patients treated with ovarian stimulation and IUI for idiopathic infertility.


METHODS
Luteinizing hormone, FSH, and P plasma levels.


RESULTS
A LH and FSH surge as well as a P rise were obtained in the five patients studied.


CONCLUSIONS
A GnRH-a successfully can induce an LH surge after GnRH antagonist administration. The effect of the antagonist on the quality of the GnRH-a-induced LH surge as well as the oocyte quality remain to be evaluated.
Olivennes
F
F
Department of Obstetrics and Gynecology, Antoine Béclère Hospital, Clamart, France.
Fanchin
R
R
Bouchard
P
P
Taieb
J
J
Frydman
R
R
D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D010865:Pilot Projects; D011374:Progesterone / Q000097:blood
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone