Reactive astrocytes express substance-P immunoreactivity in the adult forebrain after injury.
Transformation of normal resting astrocytes to reactive astrocytes after injury is a well-known phenomenon. Using immunofluorescent labelling methods, astrocytes in the ischemically and retrogradely/anterogradely damaged adult forebrain nuclei were shown to express substance-P immunoreactivity. In contrast, astrocytes were not immunostained for substance-P in the normal brain or undamaged areas. Since substance-P has been shown to regulate inflammatory, wound-healing and immune responses in the peripheral tissues, it is likely that this aberrant expression of substance-P immunoreactivity in reactive astrocytes may relate to similar functions in the central nervous system as in the peripheral tissues after injury.
Lin
R C
RC
Department of Anatomy and Neurobiology, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19102, USA.
D000818:Animals; D001253:Astrocytes / Q000737:chemistry*; D005455:Fluorescent Antibody Technique; D005849:Gerbillinae; D016548:Prosencephalon / Q000737:chemistry* / Q000166:cytology / Q000293:injuries; D013373:Substance P / Q000032:analysis*
D013373:Substance P