A new approach to the control of central deafferentation pain--spinal intrathecal baclofen.
We investigated the short-term effects of an intrathecal bolus injection of baclofen on central pain due to stroke or spinal cord injury. Pain relief was obtained in 64% of the patients. The effects developed 1-2 hours after the injection and continued for 10-24 hours. Both spinal segmental and supraspinal mechanisms may be involved in the production of baclofen-analgesia.
Taira
T
T
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College, Japan.
Kawamura
H
H
Tanikawa
T
T
Kawabatake
H
H
Iseki
H
H
Ueda
A
A
Takakura
K
K
D000344:Afferent Pathways / Q000187:drug effects; D000368:Aged; D001418:Baclofen / Q000008:administration & dosage* / Q000009:adverse effects; D002561:Cerebrovascular Disorders / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000188:drug therapy*; D013119:Spinal Cord Injuries / Q000150:complications*
D009125:Muscle Relaxants, Central; D001418:Baclofen