[Thiol group content in blood serum and in tumor tissue of rats with intact and radioresistant variants of Guerin carcinoma].
Interrelation between the formation of the secondary acquired radioresistance of Guerin carcinoma cells and dynamics of content of thiol groups in the tumour tissue and blood serum of rats have been studies. It is established that the tumour tissue and normal tissues (blood serum) of rats with Guerin's carcinoma respond to the fractional radiation action and to repeated courses of radiation therapy by the reactive increase of the number of free non-protein thiol groups and by the decrease of the content of protein thiols. The use of local superhigh-frequency-hypothermia in the pattern of treatment of the Guerin carcinoma strain resistant to irradiation is accompanied by the increase of the reaction capacity of non-protein thiol groups of the tumour tissue. At the same time the level of general thiol groups in the blood serum decreases while their reactivity increases.
Baraboĭ
V A
VA
Kulik
G I
GI
Zinchenko
V A
VA
Korol'
V I
VI
D000818:Animals; D008297:Male; D009374:Neoplasms, Experimental / Q000737:chemistry*; D011836:Radiation Tolerance / Q000502:physiology*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000097:blood
D013438:Sulfhydryl Compounds
Soderzhanie tiolovykh grupp v syvorotke krovi i v tkani opukholi krys s intaktnym i radiorezistentnym variantami kartsinomy gerena.