title: CPx-type ATPases: a class of P-type ATPases that pump heavy metals.
abstract: ATP-driven heavy metal pumps represent a newly defined class of proteins that translocate toxic and essential metals across biological membranes. These transporters form a separate evolutionary branch of the ion-transporting P-type ATPases. We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif.
authors: Department of Clinical Pharmacology, University of Berne, Switzerland. solioz@ikp.unibe.ch
authors: M
authors: M
authors: Solioz
authors: C
authors: C
authors: Vulpe
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D000595:Amino Acid Sequence; D017124:Conserved Sequence; D006801:Humans; D016623:Ion Pumps / Q000378:metabolism*; D008670:Metals / Q000378:metabolism*; D008969:Molecular Sequence Data
chemical_list: D016623:Ion Pumps; D008670:Metals; D000251:Adenosine Triphosphatases