Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins.
Human serum paraoxonase is located on an HDL. It has the capacity to retard the accumulation of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has a genetic polymorphism that results in a single amino acid substitution. Evidence indicates that both the serum concentration of paraoxonase and an individual's genotype are related to plasma lipid and lipoprotein concentrations, and possibly also to coronary heart disease, implicating paraoxonase in the development of atherosclerosis.
Mackness
M I
MI
Department of Medicine, Manchester Royal Infirmary, UK.
Mackness
B
B
Durrington
P N
PN
Connelly
P W
PW
Hegele
R A
RA
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000818:Animals; D043303:Aryldialkylphosphatase; D004950:Esterases / Q000097:blood / Q000737:chemistry / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007306:Insecticides / Q000633:toxicity; D007700:Kinetics; D008074:Lipoproteins / Q000097:blood*; D009943:Organophosphorus Compounds; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000502:physiology; D010741:Phospholipases A / Q000502:physiology; D013329:Structure-Activity Relationship
D007306:Insecticides; D008074:Lipoproteins; D009943:Organophosphorus Compounds; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D004950:Esterases; D010741:Phospholipases A; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D043303:Aryldialkylphosphatase