title: The mechanisms responsible for lack of reproducible induction of atrioventricular nodal reentrant tachycardia.
abstract: BACKGROUND
  AV nodal reentrant tachycardia (AVNRT) is not always reproducibly inducible. The purpose of this study was to determine the mechanisms responsible for the lack of reproducible induction of AVNRT.
  
  
  RESULTS
  The induction of AVNRT was assessed with atrial burst pacing, and with atrial and ventricular programmed stimulation, each with one and two extrastimuli, in 103 patients with AVNRT. The stimulation protocol was repeated 10 times in the baseline state, during isoproterenol infusion, and after atropine administration, or until AVNRT was induced in 7 of 10 attempts. The mechanisms responsible for < 7 of 10 inductions were classified as: (1) the inability to achieve critical AH prolongation; (2) fast pathway block; and (3) slow pathway block. The induction endpoint was achieved in 90 patients: 55 in the baseline state, 34 during isoproterenol infusion, and 1 after atropine. The mechanism of noninducibility in the baseline state (n = 48) was the inability to achieve a critical AH interval in 20%, fast pathway block in 49%, and slow pathway block in 31% (P = 0.02). During isoproterenol administration (n = 14) and after atropine administration (n = 13), the three mechanisms were equally responsible for nonreproducible induction of AVNRT.
  
  
  CONCLUSIONS
  The induction of AVNRT is poorly reproducible in approximately 10% of patients. In the baseline state, the most common reason for the inability to reproducibly induce AVNRT is fast pathway block. In the presence of isoproterenol or atropine, each of the three mechanisms was equally responsible for noninducibility of AVNRT.
authors: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA.
authors: S A
authors: SA
authors: Strickberger
authors: E G
authors: EG
authors: Daoud
authors: M J
authors: MJ
authors: Niebauer
authors: C
authors: C
authors: Hasse
authors: K C
authors: KC
authors: Man
authors: F
authors: F
authors: Morady
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D001283:Atrioventricular Node / Q000187:drug effects; D001285:Atropine / Q000494:pharmacology; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000494:pharmacology; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D000318:Adrenergic beta-Agonists; D010276:Parasympatholytics; D001285:Atropine; D007545:Isoproterenol