title: Postnatal changes in activation of polyunsaturated fatty acid, acylation of lysophosphoglyceride, and phosphorylation of diacylglycerol in cortical gray matter of rat cerebrum.
abstract: Activation of polyunsaturated fatty acid, acylation of lysophosphoglyceride, and phosphorylation of diacylglycerol in postnatal developing rat cerebrum were studied in vitro, using cortical gray matter homogenates. The rate of n-3 and n-6 fatty acid activation was maximal at ten days after birth and minimal at adulthood. Acylation of lysophosphoglyceride was most active at the neonatal stage and gradually decreased with age. In addition, the amount of phosphatidic acid formed from 1, 2-dioleoyl-glycerol was also maximum at the neonatal stage, and then gradually decreased. These results suggest that the specific activity of glycerolipid synthesis in cortical gray matter declines during postnatal development.
authors: Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
authors: A
authors: A
authors: Kanazawa
authors: Y
authors: Y
authors: Watanabe
authors: K
authors: K
authors: Fujimoto
mesh_terms: D000215:Acylation; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D005994:Glycerophosphates / Q000378:metabolism*; D008246:Lysophospholipids / Q000378:metabolism*; D008297:Male; D010712:Phosphatidic Acids / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004075:Diglycerides; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D005994:Glycerophosphates; D008246:Lysophospholipids; D010712:Phosphatidic Acids; C017476:lysophosphoglycerides