The uptake of gamma-aminobutyric acid and glutamate by synaptosomes from the visual cortex of albino and pigmented rabbits.
The synaptosomal uptake of glutamate and gamma aminobutyric acid [GABA] in the visual cortex of albino and pigmented rabbits was compared. GABA uptake was similar in both pigmented and albino rabbits, but glutamate uptake was greater in the pigmented rabbit. The kinetics of glutamate uptake in albino and pigmented rabbits suggested that the number of functioning glutamate synapses may be lower in the albino. The significance of this with respect to the differences in visual processing in the two types of rabbit is discussed.
Burbridge
T
T
Physiology Unit, School of Molecular and Medical Biosciences, University of Wales College of Cardiff, United Kingdom.
Choudhury
B P
BP
Collard
K J
KJ
D000417:Albinism / Q000378:metabolism*; D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D011817:Rabbits; D013569:Synapses / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism* / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid