An atomic basis of cancer (V): A new marker in animal tumors.
Particle-induced X-ray emission (PIXE) analysis can be applied to mark (or to localize) a cancer lesion in a benign environment in test animals. We synthesized hematoporphyrin derivative (HPD) with rare earth metals to form lanthanide-HPD to enhance the localizing efficiency. The sensitive PIXE detection of trace elements in amounts on the order of nanograms or less could possibly be used to probe carcinogenesis at the level of the cell. To explain the present approach, we present the results of an experiment in which we used paraseodynium-HPD localizer.
Wei
C C
CC
Eva Green Cancer Institute, Taipei, Taiwan.
Wang
C W
CW
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D006415:Hematoporphyrins / Q000138:chemical synthesis; D008114:Liver Neoplasms, Experimental / Q000737:chemistry; D008674:Metals, Rare Earth / Q000138:chemical synthesis; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000737:chemistry*; D010190:Pancreatic Neoplasms / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D014131:Trace Elements / Q000032:analysis*
D014408:Biomarkers, Tumor; D006415:Hematoporphyrins; D008674:Metals, Rare Earth; D014131:Trace Elements