[Evaluation of selected parameters of zinc metabolism in patients with primary hypertension].
The aim of the study was to investigate the role of zinc (Zn) in essential hypertension (EH).


METHODS
Material of the study consisted of 31 patients (12 female, 19 male) with mild and moderate EH and 20 healthy persons (NT) (7 female, 13 male). Erythrocyte (ZnE) and serum (ZnS) zinc as well as 24 hour urinary zinc excretion (ZuU) were assessed in both groups. Zn parameters were measured by atomic absorption spectrophotomery.


RESULTS
ZnS was lower and ZnE was higher in EH (p < 0.001) than in normotensives. ZnU did not differ between EH and NT. ZnE and ZnS negatively correlated with age in NT but not in EH, ZnU negatively correlated with age only in EH. BP positively correlated with ZnS in EH but not in NT. In both groups negative correlations were found between BP and ZnU.


CONCLUSIONS
1. Zinc probably plays a role in pathogenesis of essential hypertension.
Peczkowska
M
M
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii w Warszawie.
Kabat
M
M
Janaszek-Sitkowska
H
H
Puławska
M
M
D000328:Adult; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015032:Zinc / Q000097:blood* / Q000652:urine
D015032:Zinc
Ocena wybranych parametrów gospodarki cynkowej u chorych z pierwotnym nadciśnieniem tetniczym.