title: [Do corticotherapy and hemodilution decrease postoperative inflammation after maxillofacial surgery?].
abstract: OBJECTIVE
  To assess the efficiency of corticosteroids and preoperative acute normovolaemic haemodilution (PANHD) in reducing postoperative inflammation after maxillofacial surgery.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Thirty-two patients scheduled to undergo maxillary osteotomy for facial dysmorphia were randomized into four groups of eight (PANHD or not; corticosteroids or not).
  
  
  METHODS
  PANHD decreased haematocrit to 30%. In the corticosteroid groups, methylprednisolone 1.5 mg.kg-1 was given intravenously at the beginning of surgery (after PANHD in haemodiluted group), and after surgery, 1.5 mg.kg-1 iv daily for three days. Postoperative inflammation was assessed with an X-Ray technique (radiotelemetry) providing data on tissue thickness (extent of facial oedema), and by measurement of plasma concentrations of four acute phase proteins during the first postoperative week.
  
  
  RESULTS
  No change in facial oedema and in acute phase proteins occurred with PANHD. Corticosteroids decreased postoperative oedema and acute phase proteins.
  
  
  CONCLUSIONS
  Corticosteroids decrease postoperative inflammation after maxillofacial surgery but not PANHD.
authors: Département d'anesthésie-réanimation, centre hospitalier Lyon-Sud, Pierre-Bénite, France.
authors: D
authors: D
authors: Peillon
authors: J
authors: J
authors: Dubost
authors: C
authors: C
authors: Roche
authors: J
authors: J
authors: Bienvenu
authors: P
authors: P
authors: Breton
authors: P Y
authors: PY
authors: Carry
authors: M
authors: M
authors: Freidel
authors: V
authors: V
authors: Banssillon
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005147:Facial Bones / Q000002:abnormalities / Q000601:surgery*; D005260:Female; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D010027:Osteotomy; D011183:Postoperative Complications; D012886:Skull / Q000002:abnormalities / Q000601:surgery*
chemical_list: D000209:Acute-Phase Proteins; D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
vernacular_title: La corticothérapie et l'hémodilution diminuent-elles l'inflammation postopératoire après chirurgie maxillofaciale?