title: [Use of the the ED046 kit to analyze serum KL-6 in patients with pneumonitis].
abstract: KL-6 is a mucinous glycoprotein expressed on Type 2 pneumonocytes, and serum levels of KL-6 are reported to be abnormally high in patients with interstitial pneumonia. A new assay kit for serum KL-6 (ED046) was used in the evaluation of patients with pneumonitis. To clarify whether KL-6 is a useful marker of pneumonitis activity, 649 subjects were studied, including 185 healthy controls, 187 patients with 3 types of interstitial lung diseases, and 277 patients with 4 types of non-interstitial lung diseases. The serum KL-6 level was significantly higher in the patients with pneumonitis (1285 +/- 1196 U/ml) than in the patients without pneumonitis (307 +/- 232 U/ml). The KL-6 level was also significantly higher in patients with clinically active pneumonitis (1708 +/- 1338 U/ml) than in those with inactive pneumonitis (820 +/- 796 U/ml) (p < 0.0001). Serum KL-6 levels correlated significantly with serum c-reactive protein, lactic dehydrogenase, and PaO2 values. These results suggest that the ED046 assay is useful for measuring KL-6 as a marker of pneumonitis activity.
authors: Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.
authors: S
authors: S
authors: Kitamura
authors: K
authors: K
authors: Hiwada
authors: J
authors: J
authors: Kobayashi
authors: N
authors: N
authors: Kohno
authors: T
authors: T
authors: Kawai
authors: A
authors: A
authors: Satou
authors: R
authors: R
authors: Kasukawa
authors: Y
authors: Y
authors: Kawakami
authors: M
authors: M
authors: Andou
authors: G
authors: G
authors: Nakada
authors: H
authors: H
authors: Inoue
authors: K
authors: K
authors: Itou
authors: T
authors: T
authors: Matsushima
authors: T
authors: T
authors: Ogura
authors: M
authors: M
authors: Arakawa
authors: M
authors: M
authors: Yamakido
mesh_terms: D000328:Adult; D000368:Aged; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic / Q000592:standards*
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D011933:Reagent Kits, Diagnostic