title: Loss of heterozygosity in the VNTR region of intron 1 of P53 in two retinoblastoma cases.
abstract: Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumors. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.
authors: Department of Medical Biology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors: S
authors: S
authors: Emre
authors: A
authors: A
authors: Sungur
authors: S
authors: S
authors: Bilgiç
authors: M
authors: M
authors: Büyükpamukçu
authors: I
authors: I
authors: Günalp
authors: M
authors: M
authors: Ozgüç
mesh_terms: D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D016161:Genes, Retinoblastoma; D016158:Genes, p53; D014644:Genetic Variation; D006801:Humans; D007438:Introns; D008297:Male; D018598:Minisatellite Repeats; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012175:Retinoblastoma / Q000235:genetics* / Q000473:pathology; D017384:Sequence Deletion; D014421:Turkey
chemical_list: D017931:DNA Primers