title: N30 wave amplitude of somatosensory evoked potentials from median nerve in Parkinson's disease: a pharmacological study.
abstract: We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic 1-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.
authors: I.R.C.C.S. Clinica S. Lucia, Rome, Italy.
authors: R
authors: R
authors: Traversa
authors: M
authors: M
authors: Pierantozzi
authors: R
authors: R
authors: Semprini
authors: M
authors: M
authors: Loberti
authors: M C
authors: MC
authors: Cicardi
authors: A
authors: A
authors: Bassi
authors: P
authors: P
authors: Stanzione
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects; D001058:Apomorphine / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D016022:Case-Control Studies; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008475:Median Nerve / Q000187:drug effects*; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy; D011930:Reaction Time / Q000187:drug effects; D012016:Reference Values
chemical_list: D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D007980:Levodopa; D001058:Apomorphine