[Resistance to activated protein C disclosed by postphlebitic disease. Two cases].
BACKGROUND
Recently, resistance to activated protein C has been discovered. Resistance to activated protein C appears to be the main cause of familial thrombosis.


METHODS
Two consecutive patients have been studied. Both have a venous insufficiency associated with eczema in one patient and venous ulceration in the second patient. The two patients had a personal and familial history of venous thrombosis. In both patients, a resistance to activated protein C was found associated with a mutation in the factor V gene in residue 506.


CONCLUSIONS
When a personal or familial history of the venous thrombosis is associated with symptoms of venous insufficiency, resistance to activated protein C must be added to the search for proteins C, S and anti-thrombin III deficiency.
Foueré
S
S
Service de Dermatologie, Hôpital Henri-Mondor, Créteil.
Lestang
P
P
Cosnes
A
A
Gouault-Heilmann
M
M
Revuz
J
J
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D004789:Enzyme Activation; D005165:Factor V / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000235:genetics / Q000378:metabolism*; D012883:Skin Ulcer / Q000209:etiology*; D013924:Thrombophlebitis / Q000097:blood* / Q000235:genetics
D000925:Anticoagulants; D011486:Protein C; D005165:Factor V
Résistance à la protéine activée révélée par une maladie post-phlébitique. Deux cas.