Chronic proliferative dermatitis in mice: neutrophil-endothelium interactions and the role of adhesion molecules.
The murine chronic proliferative dermatitis mutation (cpdm/cpdm) is characterized by epidermal hyperplasia and hyperproliferation of ventral and dorsal skin sites. The expression of endothelium-associated adhesion molecules was studied in combination with the binding capacity of various cell types on frozen sections of the affected skin. In correlation with the relative absence of lymphocytes in the cpdm/cpdm skin no lymphocyte binding could be observed, but avid adhesion of neutrophils was seen. Binding of neutrophils could be blocked with antibodies against L-selectin, LFA-1, CR3 and anti ICAM-1. No expression of vascular addressins or E-selectin on endothelium in the dermis was found. The cpdm/cpdm mutation has therefore characteristics of a psoriasis-like as well as a more generalized inflammatory skin condition.
Gallardo Torres
H I
HI
Department of Cell Biology and Immunology, Vrije Universiteit, Amsterdam, The Netherlands.
Gijbels
M J
MJ
HegnEsch
H
H
Kraal
G
G
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002908:Chronic Disease; D003873:Dermatitis, Exfoliative / Q000473:pathology* / Q000662:veterinary*; D019040:E-Selectin / Q000276:immunology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology / Q000502:physiology*; D005434:Flow Cytometry; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology / Q000378:metabolism; D015603:Keratinocytes / Q000473:pathology; D019041:L-Selectin / Q000276:immunology / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000378:metabolism; D008565:Membrane Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008833:Microcirculation; D009504:Neutrophils / Q000502:physiology*; D012867:Skin / Q000098:blood supply / Q000473:pathology; D019010:Vascular Cell Adhesion Molecule-1 / Q000276:immunology / Q000378:metabolism
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D019040:E-Selectin; C069886:L-selectin counter-receptors; D016169:Lymphocyte Function-Associated Antigen-1; D008565:Membrane Proteins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin