How to make my blood boil.
Two recent papers comparing the structure of a hyperthermophilic protein with its mesophilic counterpart both conclude that large networks of ion-pairs are important for hyperthermostability. How and why is not yet clear.
Goldman
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Centre for Biotechnology, PO Box 123, FIN-20521 Turku, Finland.
D000595:Amino Acid Sequence; D001105:Archaea / Q000201:enzymology; D001426:Bacterial Proteins / Q000737:chemistry; D003013:Clostridium / Q000201:enzymology; D003553:Cystine / Q000737:chemistry; D004926:Escherichia coli / Q000201:enzymology; D005969:Glutamate Dehydrogenase / Q000737:chemistry; D006358:Hot Temperature; D007209:Indole-3-Glycerol-Phosphate Synthase / Q000737:chemistry; D007477:Ions; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011489:Protein Denaturation; D017433:Protein Structure, Secondary; D016944:Sulfolobus / Q000201:enzymology
D001426:Bacterial Proteins; D007477:Ions; D003553:Cystine; D005969:Glutamate Dehydrogenase; D007209:Indole-3-Glycerol-Phosphate Synthase