title: A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1.
abstract: We developed a new monoclonal antibody. B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting.
authors: Diaclone, Besançon, France.
authors: J
authors: J
authors: Wijdenes
authors: W C
authors: WC
authors: Vooijs
authors: C
authors: C
authors: Clément
authors: J
authors: J
authors: Post
authors: F
authors: F
authors: Morard
authors: N
authors: N
authors: Vita
authors: P
authors: P
authors: Laurent
authors: R X
authors: RX
authors: Sun
authors: B
authors: B
authors: Klein
authors: J M
authors: JM
authors: Dore
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D014408:Biomarkers, Tumor; D001773:Blood Cells / Q000276:immunology; D015153:Blotting, Western; D001853:Bone Marrow / Q000276:immunology; D003001:Cloning, Molecular; D004587:Electrophoresis, Agar Gel; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology*; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D010950:Plasma Cells; D011509:Proteoglycans / Q000276:immunology*; D053668:Syndecan-1; D053667:Syndecans; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans