title: Regulatory GTPases.
abstract: The past year has witnessed a tremendous increase in our understanding of the structures and interactions of the GTPases. The highlights include crystal structures of G alpha subunits, as well as the first complex between a GTPase (Rap1A) and an effector molecule (c-Raf1 Ras-binding domain). In the field of elongation factors (EFs), three very important structures have been determined: EF-G, the ternary complex of EF-Tu.GTP with aminoacyl-tRNA, and the EF-Tu.EF-Ts complex.
authors: Institute of Molecular Biotechnology, Jena, Germany.
authors: R
authors: R
authors: Hilgenfeld
mesh_terms: D018360:Crystallography, X-Ray; D020963:GTP Phosphohydrolase-Linked Elongation Factors / Q000737:chemistry* / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010444:Peptide Elongation Factor Tu / Q000737:chemistry / Q000378:metabolism; D010445:Peptide Elongation Factors / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry; D017433:Protein Structure, Secondary; D011518:Proto-Oncogene Proteins / Q000737:chemistry; D019908:Proto-Oncogene Proteins c-raf; D012343:RNA, Transfer / Q000378:metabolism; D020668:rap GTP-Binding Proteins; D018631:ras Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010445:Peptide Elongation Factors; D011518:Proto-Oncogene Proteins; D006160:Guanosine Triphosphate; D012343:RNA, Transfer; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf; D020963:GTP Phosphohydrolase-Linked Elongation Factors; D019204:GTP-Binding Proteins; D010444:Peptide Elongation Factor Tu; D020668:rap GTP-Binding Proteins; D018631:ras Proteins