[The diagnosis of epilepsy by using blood analysis for the content of autoantibodies to glutamate neuroreceptors].
The glutamate receptor autoantibody level was studied in blood of 170 epileptic patients as well as of 114 control donors (64 patients with nonepileptic cerebral pathology and 50 healthy individuals). The elevation of autoantibodies level (higher than 140%) was observed in 63.5% of patients with paroxysmal epileptic disturbances. This elevation was observed more frequently in the initial period of the disease as well as in generalized (convulsive or nonconvulsive) fits irrespective of disease etiology. Combined application of the test with EEG method permitted to confirm the epileptic nature of the disease in 83.5% of cases. The results of repeated analysis of glutamate receptor autoantibody level in blood proved to be a significant criterion of the effectiveness of anticonvulsive therapy. It also allowed to predict the development of posttraumatic epilepsy in individuals with craniocerebral trauma in the past.
Odinak
M M
MM
Dyskin
D E
DE
Toropov
I A
IA
Emelin
A Iu
AIu
Cherepanov
A A
AA
Dambinova
S A
SA
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001927:Brain Diseases / Q000175:diagnosis; D002908:Chronic Disease; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis; D004827:Epilepsy / Q000175:diagnosis*; D004832:Epilepsy, Absence / Q000175:diagnosis; D004829:Epilepsy, Generalized / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017470:Receptors, Glutamate / Q000276:immunology*
D001323:Autoantibodies; D017470:Receptors, Glutamate
Diagnostika épilepsii s pomoshch'iu analiza krovi na soderzhanie autoantitel k neĭroretseptoram glutamata.