[Studies on ethmozine sustained-release tablet remaining-floating in stomach].
An oral sustained-release system of ethmozine (E-HBS) was developed. The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics (Kr = 0.2436 h-1). The gamma-scintiphotographic study showed that E-HBS remained in the human stomach for more than 6 hours after ingestion, much longer than the conventional tablet (1-1.5 h). The plasma concentration-time curve of E-HBS exhibited typical sustained-release characteristics. The percentage of drug released in vitro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity.
Regmi
B M
BM
Department of Pharmaceutics, China Pharmaceutical University, Nanjing.
Liu
J P
JP
Tu
X D
XD
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D016293:Moricizine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D016293:Moricizine