title: [Seroprevalence of Epstein Barr virus infection in a healthy population of Santiago de Chile].
abstract: To study the rate of infection by Epstein Barr virus (EBV) in Santiago, Chile, the prevalence of antibody to the viral capsid antigen (VCA-IgG) was determined in a group of 663 healthy individuals grouped by age and socioeconomic level (SEL). In addition, several risk factors for infection were studied. VCA-IgG was determined by ELISA. The total prevalence was 76.7%. When grouped by age and SEL, 50% of the children from low and medium SEL had been already infected by the age two, compared to 5.9% in the high SEL (p < 0.01). However, by age twenty, 90% of the total sample had already specific antibodies to EBV. Age and number of household members were positively associated with the infection. High socioeconomic level represented a delay factor in the acquisition of the virus, (p < 0.01). These results show that EBV infection is frequent in Santiago, occurring early in childhood among medium and low SEL. Hence, the classical infectious mononucleosis should be recognized more frequently among adolescents and young adults belonging to high SEL, while the clinical spectrum of associated manifestations different from the typical mononucleosis syndrome should be investigated among those exposed in early age.
authors: Departamento de Pediatría, Universidad Católica de Chile, Santiago.
authors: M
authors: M
authors: Ferrés
authors: P
authors: P
authors: Prado
authors: J
authors: J
authors: Ovalle
authors: R
authors: R
authors: Fuentes
authors: L
authors: L
authors: Villarroel
authors: C
authors: C
authors: Ferreccio
authors: P
authors: P
authors: Vial
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000956:Antigens, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007244:Infectious Mononucleosis / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D014504:Urban Health
chemical_list: D000956:Antigens, Viral; D007074:Immunoglobulin G
vernacular_title: Seroprevalencia de infección por virus de Epstein Barr en población sana de Santiago de Chile.