title: Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV.
abstract: We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA-alpha 4, LFA-1 alpha, Mac-1 alpha, ICAM-1, and beta 2 integrin into the intestinal mucosa.
authors: Department of Internal Medicine, University of California, Davis, USA.
authors: J D
authors: JD
authors: Stone
authors: C C
authors: CC
authors: Heise
authors: D R
authors: DR
authors: Canfield
authors: M J
authors: MJ
authors: Elices
authors: S
authors: S
authors: Dandekar
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D004727:Endothelium / Q000276:immunology / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016023:Integrins / Q000096:biosynthesis; D007421:Intestine, Small / Q000276:immunology* / Q000378:metabolism*; D007583:Jejunum / Q000276:immunology / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000821:virology; D008253:Macaca mulatta; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000378:metabolism* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification
chemical_list: D015815:Cell Adhesion Molecules; D016023:Integrins