A glucocorticoid antagonist, mifepristone affects anti-Candida activity of murine neutrophils in the presence of prednisolone in vitro and experimental candidiasis of prednisolone-treated mice in vivo.
The effects of a glucocorticoid-antagonist, mifepristone on the suppressive action of prednisolone for anti-Candida activity of murine neutrophils were examined. Prednisolone suppressed inhibitory activity of neutrophils to mycelial growth of Candida albicans. This suppression was cancelled in the presence of 10(-7)-10(-6) M of mifepristone in vitro. Corresponding to this in vitro action, mifepristone protected prednisolone-treated mice from lethal C. albicans infection in vivo. These results suggest that glucocorticoid-induced vulnerability to Candida infection may be recovered or normalized by application of mifepristone.
Abe
S
S
Department of Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan.
Ohnishi
M
M
Nohmi
T
T
Katoh
M
M
Tansho
S
S
Yamaguchi
H
H
D000818:Animals; D002177:Candidiasis / Q000276:immunology*; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D007165:Immunosuppression Therapy; D051379:Mice; D008813:Mice, Inbred ICR; D015735:Mifepristone / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects*; D011239:Prednisolone / Q000494:pharmacology*
D005938:Glucocorticoids; D006727:Hormone Antagonists; D015735:Mifepristone; D011239:Prednisolone