title: Alternating versus synchronous ventilation of left and right lungs in piglets.
abstract: OBJECTIVE
  We tested whether alternating ventilation (AV) of each lung (i.e. with a phase difference of half a ventilatory cycle) would decrease central venous pressure and so increase cardiac output when compared with simultaneous ventilation (SV) of both lungs.
  
  
  BACKGROUND
  If, during AV, the inflated lung expands partly via compression of the opposite lung, mean lung volume will be smaller during AV than SV. As a consequence, mean intrathoracic pressure (as cited in the literature), and therefore, central venous pressure will be smaller.
  
  
  METHODS
  The experiments were performed in seven anaesthetized and paralyzed piglets using a double-piston ventilator. Minute ventilation was the same during AV and SV. Starting at SV, we alternated three times between AV and SV for periods of 10 min.
  
  
  RESULTS
  During AV, central venous pressure was decreased by 0.7 mmHg and cardiac output was increased by 10 +/- 4.4% (mean, +/-SD) compared with SV. AV also resulted in increased arterial pressure. During one-sided inflation with closed outlet of the opposite lung, a pressure rise occurred in the opposite lung, indicating compression.
  
  
  CONCLUSIONS
  The higher cardiac output during AV than SV can be explained by the fact that central venous pressure is lower during AV. This lower central venous pressure is very probably due to the lower mean intrathoracic pressure caused by compression of the opposite lung during unilateral inflation.
authors: Department of Pulmonary Diseases, Erasmus University, Rotterdam, The Netherlands.
authors: A
authors: A
authors: Versprille
authors: V
authors: V
authors: Hrachovina
authors: J R
authors: JR
authors: Jansen
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000502:physiology*; D002496:Central Venous Pressure / Q000502:physiology*; D006439:Hemodynamics; D012121:Respiration, Artificial / Q000379:methods*; D015656:Respiratory Mechanics; D013552:Swine