Murine acariasis: I. Pathological and clinical evidence suggesting cutaneous allergy and wasting syndrome in BALB/c mouse.
We describe here a disease related to mite-associated ulcerative dermatitis in BALB/c mice, a strain previously classified as resistant to this condition. The disease was recognized by pruritic cutaneous pathology and wasting. Pathologic studies showed a marked allergic-type inflammation in the skin. The dominant histologic feature was extensive mast cell infiltration in cutaneous lesions and in lymphoid tissues, associated with a greatly elevated serum IgE concentration. The disease was secondary to infestation with an acarian ectoparasite Myocoptes musculinus, and seemed to represent an allergic reaction to the parasite-derived substances, with an associated wasting syndrome. This condition may be a useful experimental model for allergic diseases.
Jungmann
P
P
Unité d'Immunobiologie, CNRS URA-1961, Paris.
Guénet
J L
JL
Cazenave
P A
PA
Coutinho
A
A
Huerre
M
M
D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000276:immunology* / Q000652:urine; D005260:Female; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007073:Immunoglobulin E / Q000032:analysis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D008198:Lymph Nodes / Q000033:anatomy & histology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008924:Mite Infestations / Q000276:immunology* / Q000628:therapy / Q000652:urine; D009748:Nutrition Disorders / Q000175:diagnosis* / Q000652:urine; D012867:Skin / Q000033:anatomy & histology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007073:Immunoglobulin E