[The influence of naloxone on the antinociceptive effects of the brain system of negative reinforcement in the developing rabbit].
Participation of opioidergic mechanisms in implementation of inhibitory effects of the brain "punishment areas" upon nociceptive afferentation, was studied. The antinociceptive effect of electrical stimulation of the "areas" was either enhanced or reduced by naloxone depending on the current strength. The role of the opioids was shown to diminish with age. The results suggest that the opioids are more significant in the realization of the antinociceptive influences woned by stimulation of the "brain rewarding" than the "brain punishment areas".
Butkevich
I P
IP
Kassil'
V G
VG
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D011678:Punishment; D011817:Rabbits; D012054:Reinforcement, Psychology; D012201:Reward
D009292:Narcotic Antagonists; D009270:Naloxone
Vliianie naloksona na antinotsitseptivnye éffekty mozgovoĭ sistemy otritsatel'nogo podkrepleniia u razvivaiushchegosia krolika.