title: [Hypomagnesemic and hypocalcemic coma, convulsions and ocular motility disorders after chemotherapy with platinum compounds].
abstract: We describe a case of neurologic manifestations including coma, convulsion and eye movement disorders, associated with hypomagnesemia and hypocalcemia in a patient treated with cisplatin for an ovarian adenocarcinoma. Pathophysiological mechanisms involve renal tubular damage leading to renal magnesium wasting and related hypocalcemia.
authors: Service de médecine interne, hôpital Hôtel-Dieu, Paris, France.
authors: C
authors: C
authors: Bachmeyer
authors: Y
authors: Y
authors: Decroix
authors: J
authors: J
authors: Médioni
authors: R
authors: R
authors: Dhôte
authors: K
authors: K
authors: Benfiguig
authors: P
authors: P
authors: Houillier
authors: G
authors: G
authors: Grateau
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced*; D008274:Magnesium / Q000097:blood*; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D008274:Magnesium; D002945:Cisplatin
vernacular_title: Coma, crise convulsive et troubles de l'oculomotricité hypomagnésémiques et hypocalcémiques après chimiothérapie par sels de platine.