Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.
The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice.
Colling
S B
SB
Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College, London, UK.
Collinge
J
J
Jefferys
J G
JG
D000200:Action Potentials; D000704:Analysis of Variance; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D018999:Charybdotoxin / Q000494:pharmacology; D003433:Crosses, Genetic; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011328:Prions / Q000235:genetics*; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology*; D011995:Recombination, Genetic
D015221:Potassium Channels; D011328:Prions; D018999:Charybdotoxin; D002118:Calcium