The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids.
The skin of the Mexican hairless dog is covered with comedones, and this animal therefore provides a potentially useful model to assess the comedolytic activity of topical anti-acne drugs. We treated an animal with three different formulations of tretinoin for a 14-week period, and all produced a similar clinical response. There was a striking reduction in the number of comedones, and the skin became lighter and more uniform in colour. Histological changes were similar to those reported in humans treated with tretinoin, but a novel finding was incomplete neogenesis of hair follicles. We suggest that the Mexican hairless dog may be a useful model for screening novel molecules for retinoid activity.
Schwartzman
R M
RM
Department of Dermatology, University of Pennsylvania, Philadelphia 19104-6142, USA.
Kligman
A M
AM
Duclos
D D
DD
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D018859:Hair Follicle / Q000187:drug effects* / Q000254:growth & development; D007641:Keratolytic Agents / Q000627:therapeutic use*; D012880:Skin Pigmentation / Q000187:drug effects; D014212:Tretinoin / Q000737:chemistry / Q000627:therapeutic use*
D007641:Keratolytic Agents; D014212:Tretinoin