[Excitation of hypothalamic nucleus arcuatus neuron induced decrease of plasma sialic acid level in rats].
The effect of sodium glutamate (Glu) on plasma sialic acid (SA) level was studied by means of microinjection into the nucleus arcuatus (ARC) and ultraviolet spectrophotometry. The results indicate: (1) The plasma SA level was significantly decreased after microinjection of Glu into the ARC (P < 0.01). With increasing Glu concentration, the onset of the decrease occurred earlier. (2) When Glu was microinjected into ARC after intraventricular injection of apomorphine, the plasma SA level was significantly decreased (P < 0.01) and the time required to cause the decrease was shortened. (3) When Glu was microinjected into ARC after intraventricular injection of spiperone, no change was found in the plasma SA level (P > 0.05). The above results suggest that the mechanism underlying the decrease of plasma SA level is probably related to modulated dopamine (DA) release of hypothalamic dopaminergic neurons by DA-D2 receptor.
Chen
W F
WF
Department of Physiology, Qingdao Medical College.
Chen
J J
JJ
Chen
L
L
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000097:blood*; D012970:Sodium Glutamate / Q000494:pharmacology*
D012794:Sialic Acids; D012970:Sodium Glutamate