[Methods for diagnosing the physiopathological mechanisms of bronchial obstruction].
This study aimed at clarification of pathophysiological mechanisms underlying bronchial obstruction in 28 18-71-year-old patients with chronic bronchitis (CB) diagnosed 2-8 years before. The patients had moderate obstructive disorders in distal parts of the bronchial tree. Investigations revealed a group of patients with paradoxical response to beta-blockers manifesting as lowering of bronchial resistance and high speed. Bronchial obstruction in these patients proved to arise primarily from early expiratory collapse of small bronchi. Administration of beta-mimetic and beta-blocking agents may serve as pharmacological tests able to discover mechanisms of bronchial obstruction and help in the choice of adequate therapy for chronic bronchitis.
Kuznetsova
A G
AG
Larin
N V
NV
Ivanov
A V
AV
D000293:Adolescent; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D000328:Adult; D000368:Aged; D000420:Albuterol; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology; D001991:Bronchitis / Q000175:diagnosis* / Q000503:physiopathology; D001993:Bronchodilator Agents; D002908:Chronic Disease; D006801:Humans; D008875:Middle Aged; D011433:Propranolol; D012129:Respiratory Function Tests / Q000706:statistics & numerical data
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D001993:Bronchodilator Agents; D011433:Propranolol; D000420:Albuterol
Metody diagnostiki nekotorykh patofiziologicheskikh mekhanizmov bronkhial'noĭ obstruktsii.