title: Acute mediastinitis secondary to leakage of parenteral nutrition from a migrated central venous catheter in a patient undergoing autologous bone marrow transplant.
abstract: We describe an unusual case of pyrexia of unknown origin in a patient undergoing autologous bone marrow transplantation for metastatic breast cancer. The fever was due to extravasation of lipid-containing hyperalimentation fluid from a migrated central venous catheter into the mediastinum, resulting in mediastinitis and pleurisy. The fever persisted despite broad-spectrum antibiotics and amphotericin B, and finally responded to steroids.
authors: Division of Oncology@Hematology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
authors: Y K
authors: YK
authors: Keung
authors: J
authors: J
authors: Gendreau
authors: A
authors: A
authors: Barber
authors: E
authors: E
authors: Cobos
mesh_terms: D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000628:therapy; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008480:Mediastinitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone