title: Amphetamine-induced Fos expression in globus pallidus is altered by frontal cortex injury.
abstract: Functional recovery from cortical injury may result from subcortical compensatory processes. This study examined basal gangliar expression of the immediate early gene c-fos after unilateral medial agranular cortex (AGm) ablation. In the ipsilateral dorsal globus pallidus of rats demonstrating neglect of contralateral stimuli (sacrificed 5 days postinjury), the numbers of amphetamine-induced Fos-positive nuclei were reduced 37% compared to intact hemisphere values. These reductions were no longer apparent in recovered AGm-ablated rats (sacrificed 21 + days postinjury). These findings mirror in timing and direction the changes in Fos seen in dorsolateral striatum after AGm ablation.
authors: Department of Psychobiology, University of California, Irvine 92717-4550, USA.
authors: J M
authors: JM
authors: Vargo
authors: M S
authors: MS
authors: Estrick
authors: J F
authors: JF
authors: Marshall
mesh_terms: D000161:Acoustic Stimulation; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism*; D009949:Orientation; D017397:Prefrontal Cortex / Q000293:injuries*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D014110:Touch / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D016760:Proto-Oncogene Proteins c-fos; D000661:Amphetamine