title: Intraoperative biliary tree imaging with cholyl-lysyl-fluorescein: an experimental study in the rabbit.
abstract: Iatrogenic bile duct injury during cholecystectomy is the most serious complication of this surgical procedure. Initial reports suggest that this complication is particularly troublesome during laparoscopic cholecystectomy. Proper identification of the biliary anatomy in the subhepatic region is the only way to avoid this catastrophe. The potential benefits of a simple, reliable method for intraoperative delineation of biliary anatomy are self-evident. In this experimental study on rabbits, we show how the simple i.v. injection of a fluorescent bile salt, cholyl-lysyl-fluorescein, enables the surgeon to visualize the entire biliary tree in anatomic detail.
authors: III Surgical Clinic, University La Sapienza, Rome, Italy.
authors: A
authors: A
authors: Oddi
authors: C O
authors: CO
authors: Mills
authors: F
authors: F
authors: Custureri
authors: V
authors: V
authors: Di Nicola
authors: E
authors: E
authors: Elias
authors: G
authors: G
authors: Di Matteo
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000008:administration & dosage; D001652:Bile Ducts / Q000473:pathology / Q000601:surgery*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D004195:Disease Models, Animal; D019793:Fluorescein; D005452:Fluoresceins / Q000008:administration & dosage; D005456:Fluorescent Dyes / Q000008:administration & dosage; D007275:Injections, Intravenous; D016343:Monitoring, Intraoperative / Q000379:methods*; D011817:Rabbits; D012680:Sensitivity and Specificity
chemical_list: D001647:Bile Acids and Salts; D005452:Fluoresceins; D005456:Fluorescent Dyes; D019793:Fluorescein