title: [Immunostimulating protein 90K in ovarian carcinoma].
abstract: Protein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes. In our in vitro experiences we observed a stimulatory effect by IFN-alpha and IFN-gamma on 90K-specific mRNA expression and protein release in ovarian cancer cells, and 90K was furthermore found to be a potent stimulator of macrophage activity. Protein 90K seems to be involved in tumor immunology; it may represent a critical link between tumor and immune system.
authors: Universitätsklinik für Frauenheilkunde, Innsbruck.
authors: A G
authors: AG
authors: Zeimet
authors: C
authors: C
authors: Marth
authors: D
authors: D
authors: Fuchs
authors: M
authors: M
authors: Herold
authors: M
authors: M
authors: Widschwendter
authors: G
authors: G
authors: Daxenbichler
authors: S
authors: S
authors: Iacobelli
authors: O
authors: O
authors: Dapunt
mesh_terms: D000276:Adjuvants, Immunologic / Q000502:physiology*; D000951:Antigens, Neoplasm / Q000502:physiology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology; D007371:Interferon-gamma / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D016898:Interferon-alpha; D007376:Interleukin-2; D009363:Neoplasm Proteins; D012333:RNA, Messenger; C017589:ovarian tumor associated antigen; D007371:Interferon-gamma
vernacular_title: Das immunstimulierende Protein 90K beim Ovarialkarzinom.