[Turner syndrome: spontaneous growth of stature, weight increase and accelerated bone maturation].
BACKGROUND
Since growth hormone is effective in increasing the height of girls with Turner's syndrome, it is important to dispose of growth and bone maturation curves in a large number of untreated patients.


METHODS
Data on growth and bone maturation were collected from 160 patients with Turner's syndrome (50 have reached final height), born 1965-1991, untreated with growth hormone or anabolic steroids. X monosomy was found in half of the patients, mosaicism or X abnormality was present in the other half. Spontaneous puberty occurred in 25% (n = 25) of patients older than 13 years, 38 patients received estrogen after 13 years. Final heights were compared to predicted height according to Lyon's method.


RESULTS
Forty-five percent of patients were small for date. Height velocity decreased from 2 years of age and decreased faster during adolescence, when gonadal dysgenesis occurred. Bone maturation velocity decreased also during adolescence. Excessive weight appeared after the age of 5 years. Patients with partial deletion of the long arm of X (n = 6) were taller than the other girls (n = 44) (mean +/- DS) 152.5 +/- 3.1 cm, range 150-158 cm versus 142.5 +/- 4.9 cm, 130-150 cm (P < 0.0001). Final height was not modified by spontaneous puberty. Final height was correlated with birth weight (r = 0.7), maternal height (r = 0.5) and mid parental height (r = 0.5). Finally, the Lyon's method for predicted final height seemed to be suitable for this population, (r = 0.8, P < 0.001).


CONCLUSIONS
Appropriate growth curve is an essential clinical tool in evaluating treatment aimed at increasing final stature in patients with Turner's syndrome.
Cabrol
S
S
Laboratoires d'explorations fonctionnelles endocriniennes, hôpital Armand-Trousseau, Paris, France.
Saab
C
C
Gourmelen
M
M
Raux-Demay
M C
MC
Le Bouc
Y
Y
D000293:Adolescent; D001827:Body Height; D001835:Body Weight; D001846:Bone Development; D002872:Chromosome Deletion; D002875:Chromosomes; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D005500:Follow-Up Studies; D006128:Growth; D006801:Humans; D011247:Pregnancy; D014424:Turner Syndrome / Q000235:genetics / Q000503:physiopathology*
Syndrome de Turner: croissance staturopondérale et maturation osseuse spontanées.