[Double filtration and immunoadsorption plasmapheresis in Guillain-Barré syndrome].
We studied the effect of double filtration and immunoadsorption plasmapheresis in Guillain-Barré syndrome retrospectively in 70 patients. Thirty three patients had plasmapheresis, of whom 23 had double filtration and 10 immunoadsorption. The rest of 37 patients consisted of a control group. Clinical disability was evaluated using the functional grading scale by Hughes. In patients having a maximum disability of grade 4 and 5, the double filtration plasmapheresis group showed statistically significant improvement at 3 months after the treatment. There was no significant difference in prognoses between the immunoadsorption plasmapheresis and control groups. In mildly-illed patients having grade 2 and 3, the prognoses were not different between the three groups. In Guillain-Barré syndrome, double filtration plasmapheresis, as well as well-established plasma exchange, had benefit for severely-illed patients.
Kuwabara
S
S
Department of Neurology, School of Medicine, Chiba University.
Nakajima
M
M
Moroo
I
I
Hirayama
K
K
D000328:Adult; D005260:Female; D005374:Filtration; D006801:Humans; D007163:Immunosorbent Techniques; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D011129:Polyradiculoneuropathy / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index