Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver.
The soluble epoxide hydrolase mRNA level in liver was increased eight-fold upon administration of the hypolipidemic drug and peroxisome proliferator clofibrate for 7 days to mice. The soluble epoxide hydrolase mRNA was back at control levels within 1-2 days after clofibrate withdrawal. The highest expression was in liver, intestine and kidney. Lower levels were found in heart and muscle and very low levels were found in testes, lung, brain and spleen. The mRNA levels were increased in liver, kidney and heart by clofibrate.
Johansson
C
C
Department of Cell Research, Swedish University of Agricultural Sciences, Uppsala.
Stark
A
A
Sandberg
M
M
Ek
B
B
Rask
L
L
Meijer
J
J
D000821:Animal Feed / Q000633:toxicity; D000818:Animals; D015152:Blotting, Northern; D002994:Clofibrate / Q000633:toxicity*; D004851:Epoxide Hydrolases / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics; D007422:Intestines / Q000187:drug effects* / Q000201:enzymology; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity / Q000187:drug effects* / Q000235:genetics; D012333:RNA, Messenger / Q000187:drug effects*; D012995:Solubility
D012333:RNA, Messenger; D004851:Epoxide Hydrolases; D002994:Clofibrate