title: Acrolocalized acquired cutis laxa.
abstract: A 55-year-old man presented with a 14-year history of loose, redundant skin on the palmar aspects of the finger tips and toe pulps, which gave a peculiar 'chewing gum' appearance. Skin biopsies of involved areas showed a normal appearance, and only a discrete decrease in the elastic fibres could be identified with an elastic tissue stain. Ultrastructural examination, however, demonstrated marked fragmentation and degeneration of the elastic tissue. Localized cutis laxa in an acral distribution, was fully developed at presentation. He gave a history of repeated episodes of swelling and urticaria of the involved areas, which we regard as being the initial inflammatory stages of this disease process.
authors: Department of Dermatology, Universidad Autónoma, Madrid, Spain.
authors: L
authors: L
authors: Martín
authors: L
authors: L
authors: Requena
authors: E S
authors: ES
authors: Yus
authors: V
authors: V
authors: Furio
authors: M C
authors: MC
authors: Fariña
mesh_terms: D003483:Cutis Laxa / Q000473:pathology*; D004547:Elastic Tissue / Q000648:ultrastructure*; D005143:Eyelids / Q000648:ultrastructure; D005533:Foot Dermatoses / Q000473:pathology*; D006229:Hand Dermatoses / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013933:Thumb