title: Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles.
abstract: In summary (1) Nonpregnant women with RSAs of unknown etiology have higher levels of CD56+ lymphocytes when compared to normal controls; (2) The levels of CD19+, CD56+, and CD56+/CD16+ PBL of pregnant women with RSA are significantly higher than those of multiparous pregnant normal controls; (3) Women with autoantibodies to phospholipids have significantly higher levels of elevated CD56+ and CD56+/CD16+ lymphocytes when compared to women without antiphospholipid antibodies; (4) Women with autoantibodies to nuclear components demonstrate higher numbers of CD19+/CD5+ cells compared to women without autoantibodies to nuclear components; (5) Idiopathic infertile women with multiple prior IVF failures demonstrate significantly higher levels of CD56+ pBL than normal fertile controls and the conception rate is much higher in those with CD56+ levels less than 12%; (6) Elevations of CD56+ lymphocytes to over 18% during a pregnancy is a good prognostic indicator of impending pregnancy loss. We have not seen a liveborn infant in women with levels of 18% or higher without IVIg therapy; and (7) Infertile and RSA women who fail alloimmune and autoimmune therapy have significant alterations in cellular and humoral immunity involving NK cells and CD19+/CD5+ B cells.
authors: Department of Obstetrics and Gynecology, Finch University of Health Sciences, Chicago Medical School, Illinois 60064, USA.
authors: A E
authors: AE
authors: Beer
authors: J Y
authors: JY
authors: Kwak
authors: J E
authors: JE
authors: Ruiz
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D018956:CD5 Antigens / Q000032:analysis; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016130:Immunophenotyping; D007247:Infertility, Female / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000145:classification*; D011247:Pregnancy
chemical_list: D017152:Antibodies, Antiphospholipid; D018956:CD5 Antigens