Hepatotoxicity of antimicrobial, antifungal, and antiparasitic agents.
Several antibiotics are known to be hepatotoxic. Apart from subtle, reversible, and often inconsequential abnormalities, cholestasis is the predominant presentation that has a protracted and disabling course. Hepatitis, like illness, is characteristic of some drugs, and chronic liver disease may evolve. It is important to recognize if a patient has an adverse reaction to a drug because continuing use of the drug in the face of hepatitis can have disastrous consequences. Chronic liver disease may ensue and progress onto cirrhosis; this has typically been seen following use of isoniazid and nitrofurantoin. Cholestatic liver disease can progress into a chronic form of a ductopenic state; this is particularly seen after antibiotic-related cholestasis.
Reddy
K R
KR
Department of Internal Medicine, University of Miami School of Medicine, FL 33136, USA.
Schiff
E R
ER
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D000977:Antiparasitic Agents / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000977:Antiparasitic Agents