Effects of an anaesthetic on plasma levels of histamine and tele-methylhistamine in the cat.
The effects of intravenous injection of ketamine on plasma levels of histamine (Hi) and its metabolite, tele-methylhistamine (MeHi) were studied in the cat. The results showed that the anaesthetic, given in doses which prolonged anaesthesia in the cat (2.5-7.5 mg/kg) caused Hi release, which raised the concentrations of Hi in plasma up to 1600%. It was followed by a slower and also significant increase of plasma MeHi levels (up to 1200%). When urethane was used as an anaesthetic no changes of plasma levels were noticed. However, about 50% of i.v. injections of Ringer-Locke solution were followed by a transient increase of plasma Hi and MeHi concentrations.
Irman-Florjanc
T
T
Department of Pharmacology, Medical Faculty, University of Ljubljana, Slovenia.
D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000097:blood*; D006637:Histamine N-Methyltransferase / Q000037:antagonists & inhibitors; D006636:Histamine Release / Q000187:drug effects; D007275:Injections, Intravenous; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008761:Methylhistamines / Q000097:blood*; D014520:Urethane / Q000008:administration & dosage / Q000494:pharmacology
D000777:Anesthetics; D000778:Anesthetics, Dissociative; D004791:Enzyme Inhibitors; D008761:Methylhistamines; D014520:Urethane; D007649:Ketamine; D006632:Histamine; D006637:Histamine N-Methyltransferase; C020404:tele-methylhistamine