[A prospective study on relationship between abnormal nasopharyngeal mucosa and nasopharyngeal carcinoma].
Abnormal nasopharyngeal mucosa was defined as abnormal finding under the examination of nasopharyngoscope. 43541 healthy persons aged 30-64 were observed for 6 years in the high risk area of NPC, by mean of EBV serological and nasopharyngeal cavity examination. The results are as follows. 1. In the high risk area of NPC, abnormal nasopharyngeal mucosa such as follicle hyperplasia and bulge are common in the younger people, especially in the post-roof of the nasopharyngeal cavity. 2. There was no significant difference on statistics between the abnormal and normal groups on the positive rate and GMT of EBV VCA/IgA. Abnormal nasopharyngeal mucosa did not change with the change of VCA/IgA titer. 3. There was significant difference on the prevalence rate of NPC between the abnormal nasopharyngeal mucosa and normal groups except the age, sex factors. There was no confirmation of the abnormal nasopharyngeal mucosa as precancerous lesion.
Huang
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Cancer Center, Sun Yet-sen University of Medical Sciences, Guangzhou.
Chen
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Huang
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D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D002213:Capsid / Q000276:immunology; D036022:Capsid Proteins; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000473:pathology*; D009305:Nasopharynx / Q000473:pathology*; D011446:Prospective Studies; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen; D007070:Immunoglobulin A