The reversal of experimental hemorrhagic shock induced by nicotine and dimethylphenylpiperazinium is adrenal-dependent.
In a rat model of volume-controlled hemorrhagic shock causing the death of all control animals within 30 min, the intravenous injection of either nicotine (50 micrograms/kg) or dimethylphenylpiperazinium (DMPP) (0.5 micrograms/kg) produced a rapid and sustained reversal of the shock condition, with 100% survival 2 h after treatment. Bilateral adrenalectomy completely prevented the anti-shock effect of the two drugs, even though administered at higher doses (150 micrograms/kg in the case of nicotine; 10 micrograms/kg in the case of DMPP). It is concluded that stimulation of adrenaline release plays a fundamental role in the mechanism of action of nicotine- and DMPP-induced shock reversal.
Bazzani
C
C
Department of Biomedical Sciences, Section of Pharmacology, University of Modena, Italy.
Bertolini
A
A
Ricigliano
G M
GM
Cainazzo
M M
MM
Balugani
A
A
Guarini
S
S
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000315:Adrenalectomy; D000818:Animals; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
D005731:Ganglionic Stimulants; D004246:Dimethylphenylpiperazinium Iodide; D009538:Nicotine