Erythropoietin-induced iritis-like reaction.
The present report describes an iritis-like reaction found in 13 patients treated with recombinant human erythropoietin (Eprex), a drug given to hemodialysis patients for their chronic anemia. Among 120 patients being treated by hemodialysis in two centers affiliated with our medical center, ten out of 30 Eprex-treated patients but none of 90 not being treated with Eprex developed this reaction. The observations described support a causal relation between Eprex treatment and the iritis-like reaction. Further investigative effort is needed to establish the mechanism.
Beiran
I
I
Department of Ophthalmology, Rambam Medical Center, Haifa, Israel.
Krasnitz
I
I
Mezer
E
E
Meyer
E
E
Miller
B
B
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy; D002908:Chronic Disease; D004921:Erythropoietin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007500:Iritis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects; D016896:Treatment Outcome
D011994:Recombinant Proteins; D004921:Erythropoietin