title: The effect of ethanol and calcium channel antagonists on rabbit EEG.
abstract: The influence of nifedipine, verapamil, and cinnarizine on the effect of ethanol on EEG of rabbits (frontal cortex, hippocampus, MRF) was tested. Nifedipine (1.75 mg/kg, IP) and cinnarizine (7.5 mg/kg, IP) were given 30 min before ethanol administration. Verapamil (0.2 mg/kg, IV) was given 15 min before ethanol injection in a dose of 0.8 g/kg IV. Ethanol caused the increase of the frequencies 0.5-4 cps in the recording, as well as a marked decrease of the fastest frequencies. Verapamil prevented ethanol's effect on EEG recording. Cinnarizine antagonized this action to a smaller extent and the influence of nifedipine is transitory and less pronounced.
authors: Department of Pharmacology, Medical University of Lódź, Poland.
authors: E
authors: E
authors: Czarnecka
authors: B
authors: B
authors: Pietrzak
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002936:Cinnarizine / Q000494:pharmacology; D004569:Electroencephalography; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D002936:Cinnarizine; D000431:Ethanol; D014700:Verapamil; D009543:Nifedipine