title: Suprasellar granular cell tumor.
abstract: A 75-year-old female presented with a suprasellar granular cell tumor. Computed tomography (CT) revealed a high dense suprasellar mass with strong postcontrast enhancement. Magnetic resonance imaging showed a round suprasellar mass, which was hyperintense on the T1-weighted images with nonhomogeneous enhancement after the administration of gadolinium-diethylenetriaminepenta- acetic acid, and hypointense on the T2-weighted images. Cerebral angiography demonstrated no abnormal findings. The tumor was partially removed via a right frontotemporal craniotomy. The histological diagnosis was suprasellar granular cell tumor. Her postoperative course was uneventful other than mild and transient diabetes insipidus. She has remained asymptomatic without CT evidence of tumor regrowth for 20 months after the surgery. Immunohistochemical studies showed positive reaction for S-100 protein in the tumor cell nuclei, but no reaction for glial fibrillary acidic protein, neurofilament protein, Leu-7, oxytocin, beta-endorphin, adrenocorticotropic hormone, and vimentin. This case provides additional evidence for the astrocytic origin of suprasellar granular cell tumor.
authors: Department of Neurosurgery, Kagawa Prefectural Central Hospital, Takamatsu.
authors: E
authors: E
authors: Moriyama
authors: Y
authors: Y
authors: Matsumoto
authors: T
authors: T
authors: Meguro
authors: S
authors: S
authors: Mano
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D006801:Humans; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D017293:Protein S / Q000502:physiology; D014057:Tomography, X-Ray Computed
chemical_list: D017293:Protein S