Increased morbidity following the introduction of remote afterloading, with increased dose rate, for cancer of the cervix.
A retrospective review of the treatment of cancer of the cervix compared the 3-year period before and after the introduction of remote afterloading using a "low dose rate' Selectron. Data was collected on 270 patients. Compared to manually loaded caesium the dose rate to point A was doubled with Selectron and a dose reduction of 20% was adopted to compensate for the expected increased effectiveness. The combined grade 2 and 3 complication rates were 12% with manually loaded caesium and 32% with Selectron at the higher dose rate. Survival and local control rates were similar.
Newman
G
G
Bristol Oncology Centre, UK.
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D001706:Biopsy; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002588:Cesium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009017:Morbidity; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*
D002588:Cesium Radioisotopes