Effect of passively administered immunoglobulin G on the colonization and clearance of Bordetella avium in turkeys.
This study was conducted to detect the effect of parenterally administered immunoglobulin isotype G (IgG) on the colonization and clearance of Bordetella avium at the tracheal surface in young turkeys. In two separate experiments, 3-week-old turkeys were infected with B. avium either after or before IgG administration. Comparisons were made between a control group which received an irrelevant IgG (specific for keyhole limpet hemocyanin [KLH]) and the experimental group which received a B. avium-specific IgG. When given before the bacteria, IgG reduced the numbers of colony-forming units (CFUs) in the trachea. As a supplement to non-specific respiratory defense mechanisms, B. avium-specific IgG also appears to inhibit colonization of the tracheal mucosa. In a second experiment designed to study the role of IgG in bacterial clearance, administration of B. avium-specific IgG after bacterial inoculation significantly reduced the number of CFUs on the tracheal surface. These studies support the role of B. avium-specific IgG in resistance to and recovery from B. avium infection.
Suresh
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Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames 50011, USA.
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D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001422:Bacterial Adhesion / Q000276:immunology; D001884:Bordetella / Q000502:physiology*; D001885:Bordetella Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D015169:Colony Count, Microbial / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D018928:Immunity, Mucosal / Q000276:immunology; D007116:Immunization, Passive / Q000662:veterinary*; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology* / Q000382:microbiology; D014132:Trachea / Q000382:microbiology; D014422:Turkeys / Q000276:immunology* / Q000382:microbiology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G