title: Minocycline-induced hyperpigmentation in leprosy.
abstract: A 36-year-old man was treated with dapsone, rifampicin and clofazimine for borderline lepromatous leprosy. After 9 months, his leprosy plaques became progressively more red and after 23 months, the clofazimine was stopped and he was given minocycline instead. Six weeks later, he developed blue-black pigmentation in his leprosy lesions. The histology was consistent with minocycline-induced hyperpigmentation. This is the first report of minocycline-induced pigmentation in leprosy. We suggest it is important to consider this side-effect before the administration of minocycline in leprosy, particularly if it is prescribed in place of clofazimine.
authors: Department of Dermatology, Royal Prince Alfred Hospital, New South Wales, Australia.
authors: C J
authors: CJ
authors: Fleming
authors: M J
authors: MJ
authors: Hunt
authors: E L
authors: EL
authors: Salisbury
authors: S W
authors: SW
authors: McCarthy
authors: R S
authors: RS
authors: Barnetson
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D015440:Leprosy, Lepromatous / Q000188:drug therapy*; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline