[Double blind randomized comparative study of two antihypertensive combinations. Enalapril-hydrochlorothiazide versus enalapril-nifedipine in 240 hypertensive patients resistant to monotherapy].
The combination of two antihypertensive drugs is recommended when mild to moderate hypertension is not controlled by sequential monotherapy. The aim of our study was to compare the efficacy and the safety of the combination enalapril 20 mg-hydrochlorothiazide 12.5 mg to that of enalapril 20 mg-nifedipine SL 20 mg x 2. Two hundred and forty four hypertensive patients not controlled (DPB > 95 mmHg) by a single dose of enalapril 20 mg/24 h, received for 4 weeks, one of these two combined therapies in a randomized double-blind trial. The efficacy was of same amplitude in the two groups (DBP: -10.8 mmHg enalapril-hydrochlorothiazide vs-10.3 mmHg enalapril-nifedipine). The side effects were less frequent in the enalapril-hydrochlorothiazide group (14 per cent vs 24 per cent, p = 0.04).
Frances
Y
Y
Service de Médecine Interne et Urgences, CHU Nord, Marseille, France.
Lafay
V
V
Madona
O
O
Chastang
C
C
Souchet
T
T
Chazelle
F
F
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage* / Q000627:therapeutic use
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D004656:Enalapril; D009543:Nifedipine
Etude comparative randomisée en double aveugle de deux associations anti-hypertensives. Enalapril-hydrochlorothiazide versus enalapril nifédipine chez 240 hypertendus résistants à une monothérapie.