Neonatal alloimmune thrombocytopenia in Taiwan due to an antibody against a labile component of HPA-3a (Baka).
We report on two siblings who developed severe neonatal alloimmune thrombocytopenia (NAIT) due to an alloantibody against a labile component or components of the HPA-3a (Baka) antigen. The antibody reacted only with fresh, unfixed platelets by the solid-phase red cell adherence test, immunofluorescence test and mixed passive haemagglutination test. In the latter method, weakly fixed platelets also gave a weak positive reaction. Monoclonal-antibody-specific immobilization of platelet antigens and immunoblotting tests gave negative results. Our findings may possibly help to explain why in some cases of NAIT no platelet-specific antibody is demonstrable in tests with fixed or solubilized platelets.
Lin
M
M
Immunohematology Reference Laboratory, Tokyo University, Japan.
Shieh
S H
SH
Liang
D C
DC
Yang
T F
TF
Shibata
Y
Y
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D016824:Antigens, Human Platelet / Q000097:blood*; D000939:Epitopes; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D013624:Taiwan; D013921:Thrombocytopenia / Q000276:immunology*
C044561:3a alloantigen, human; D000911:Antibodies, Monoclonal; D016824:Antigens, Human Platelet; D000939:Epitopes; D007518:Isoantibodies