TJ6: the pregnancy-associated cytokine.
These studies have demonstrated that TJ6m protein can be measured in women prior to a spontaneous abortion based on expression of TJ6 on CD56-positive NK cells. This suggested to us a possible regulator function for TJ6 during pregnancy. We have shown that in T cells only crosslinking of the T-cell receptor can upregulate TJ6 expression and the other activators, such as mitogens, do not. A clear discrepancy in the pattern of expression of TJ6 on CD56 and CD19-positive cells was noted between successful and unsuccessful pregnancies. A successful pregnancy is denoted by TJ6 expression on B cells, whereas in a potential spontaneous abortion there is TJ6 expression on both NK and B cells.
Beaman
K
K
Department of Microbiology and Immunology, Finch University of Health Sciences, Chicago Medical School, IL 60064, USA.
Angkachatchai
V
V
Gilman-Sachs
A
A
D000818:Animals; D016207:Cytokines / Q000737:chemistry* / Q000502:physiology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000737:chemistry* / Q000502:physiology*; D013491:Suppressor Factors, Immunologic / Q000737:chemistry* / Q000502:physiology*; D006180:Proton-Translocating ATPases
D016207:Cytokines; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C525845:ATP6V0A2 protein, human; D006180:Proton-Translocating ATPases