title: Slide agglutination test for the diagnosis of pulmonary and extra-pulmonary tuberculosis.
abstract: OBJECTIVE
  Evaluation of a 2 min slide agglutination test to detect the presence of antibodies directed against Mycobacterium tuberculosis antigens.
  
  
  METHODS
  The test utilizes solible antigens extracted from a cultivable new species of non-pathogenic saprophytic mycobacterium, Mycobacterium w, which shares antigenic determinants with M. tuberculosis. The soluble antigens are covalently linked to carboxylated polystyrene latex beads.
  
  
  RESULTS
  The sensitivity of the assay was increased from 78% (reported earlier), to 90.2% for pulmonary tuberculosis and 85.7% for extra-pulmonary tuberculosis. The specificity of the test was determined by testing the sera of apparently healthy controls, and patients with other respiratory tract infections and rheumatoid arthritis. Among the apparently healthy controls, 7.3% tested positive. None of the sera from the patients with other diseases gave positive agglutination.
  
  
  CONCLUSIONS
  This simple and rapid technique could be suitable for mass screening for pulmonary and extrapulmonary tuberculosis.
authors: Product Development Cell, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
authors: S
authors: S
authors: Bhaskar
authors: N K
authors: NK
authors: Jain
authors: R
authors: R
authors: Mukherjee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007841:Latex Fixation Tests / Q000379:methods*; D008875:Middle Aged; D009161:Mycobacterium / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000175:diagnosis*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis
chemical_list: D000907:Antibodies, Bacterial