Quinine clearance in continuous venovenous hemofiltration.
OBJECTIVE
To describe a case involving the removal of quinine by continuous venovenous hemofiltration (CVVH) in a patient with malaria and acute renal failure and to present recommendations on the dosing of quinine in such patients.


METHODS
A 50-year-old white man developed Plasmodium falciparum malaria following a visit to Nigeria. Although he received intravenous quinine, his condition deteriorated and he required intensive care management, including CVVH for the management of his acute renal failure. Quinine plasma concentrations were measured to determine both total body and extracorporeal clearance of the drug.


CONCLUSIONS
To our knowledge this is the first report quantifying the removal of quinine by CVVH. The drug is not significantly removed by this extracorporeal process. The filter clearance accounted for less than 1.5% of the total body clearance.


CONCLUSIONS
Initially the dosage of quinine administered to patients presenting with P. falciparum infection should not be reduced because of renal failure. This is particularly important when cerebral involvement is suspected. Subsequent dosage modification should reflect the severity of the patient's clinical condition and the plasma quinine concentration achieved, and should not be limited by the degree of renal impairment present.
Davies
J G
JG
Department of Pharmacy, University of Brighton, England.
Greenwood
E F
EF
Kingswood
J C
JC
Sharpstone
P
P
Street
M K
MK
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D006440:Hemofiltration; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011803:Quinine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use
D011803:Quinine