A case of uveitis associated with chronic active Epstein-Barr virus infection.
Ocular complications of chronic active Epstein-Barr virus infection (CAEBV) have rarely been reported. We describe a 7-year-old girl with CAEBV with associated uveitis. The patient was first observed to have recurrent fever and hepatosplenomegaly in August 1991. She presented with left facial nerve palsy in June 1993. Ocular examination showed right iridocyclitis. Both optic disks were swollen, and the retinal vessels were dilated. Antibody titers to EBV were markedly elevated. Treatment with topical steroids. systemic interleukin-2 and splenectomy dramatically relieved all her symptoms. including the ocular ones.
Morishima
N
N
Department of Ophthalmology, Tokyo Medical and Dental University, Japan.
Miyakawa
S
S
Akazawa
Y
Y
Takagi
S
S
D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002908:Chronic Disease; D005260:Female; D005334:Fever / Q000209:etiology; D005654:Fundus Oculi; D006529:Hepatomegaly / Q000209:etiology; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology / Q000628:therapy; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use; D014412:Tumor Virus Infections / Q000150:complications* / Q000276:immunology / Q000628:therapy; D015866:Uveitis, Posterior / Q000209:etiology* / Q000276:immunology / Q000628:therapy
D000914:Antibodies, Viral; D007376:Interleukin-2; D013256:Steroids