[Generalities on vascular renal aging].
Until the last decade, kidney aging was considered to be the result of progressive loss of nephrons associated with development of glomerulosclerosis and thus decrease in glomerular filtration rate, and finally renal deficiency. However this nephropathy can also result of environmental (such as husbandry conditions, diet ...) and genetical factors. So, food restriction can protect glomeruli against hyperfiltration and risks of glomerulosclerosis. Both capillaries and large vessels were modified during aging. Concerning the glomerular capillaries, the main alterations are changes in glomerular hemodynamics and in the composition and structure of the glomerular basement membrane (noticeably thickening and decrease in heparan sulfate proteoglycans and thus in anionic barrier), glycation of both the structural and plasma protein, resulting in increased permeability of the glomerular capillary wall and development of proteinuria.
Schaeverbeke
J
J
Laboratoire de Biologie cellulaire, Université Paris VII.
D000375:Aging; D000818:Animals; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000502:physiology*; D011507:Proteinuria / Q000503:physiopathology; D051381:Rats
Généralités sur le vieillissement vasculaire rénal.