Mechanisms involved in the generation of free radicals.
Free radicals are constantly formed in the human body, both by "accidents of chemistry" and for useful metabolic purposes. Their action is opposed by a balanced and co-ordinated system of antioxidant defences. Upsetting this balance causes oxidative stress, which can lead to cell injury and death.
Halliwell
B
B
Pharmacology Group, University of London King's College.
D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000633:toxicity; D017665:Hydroxyl Radical / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism* / Q000633:toxicity; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism* / Q000633:toxicity
D016877:Oxidants; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase