[Pharmacokinetics of ipriflavone].
Ipriflavone administered to rats orally is well absorbed from small intestine via the portal route, distributed widely in tissues, metabolized extensively by oxidation, and eliminated from the body preferentially in urine. The absorption of ipriflavone is less effective in dogs, than in rats. In dogs, the compound absorbed is metabolized in the same way as in rats and the metabolites formed are eliminated largely in faeces, together with unabsorbed ipriflavone. In human, ipriflavone administered orally is rapidly absorbed, and quickly metabolized. The dose is eliminated mainly via the urinary route as metabolites (57% of the dose), and the smaller fraction with the faeces, mostly as ipriflavone (40% of the dose). There is no significant change in the pharmacokinetics of ipriflavone even after multiple dose. In the serum, ipriflavone and its metabolites are primarily bound to albumin, the binding is 94-99% and totally reversible.
Ferenc
L
L
Chinoin Gyógyszer-és Vegyészeti Termékek Gyára Rt, Budapest.
István
S
S
D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D005243:Feces; D007408:Intestinal Absorption; D007529:Isoflavones / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D007529:Isoflavones; C018986:ipriflavone
Az ipriflavon farmakokinetikája.