title: Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4.
abstract: Bone morphogenetic protein-4 (BMP-4) is thought to play an important role in early Xenopus development by acting as a "ventralizing factor' and as an epidermal determinant: local inhibition of BMP-4 function in whole embryos causes the formation of an additional dorsal axis, and inhibition of BMP-4 function in isolated ectodermal cells causes the formation of neural tissue. In this paper we describe a homeobox-containing gene whose expression pattern is similar to that of BMP-4, whose expression requires BMP-4 signalling and which, when over-expressed, causes a phenotype similar to that caused by over-expression of BMP-4. We suggest that this gene, which we call Xom, acts downstream of BMP-4 to mediate its effects.
authors: Division of Developmental Biology, National Institute for Medical Research, London, UK.
authors: R
authors: R
authors: Ladher
authors: T J
authors: TJ
authors: Mohun
authors: J C
authors: JC
authors: Smith
authors: A M
authors: AM
authors: Snape
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D018076:DNA, Complementary; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D006133:Growth Substances / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics*; D014981:Xenopus; D029867:Xenopus Proteins; D000099176:Noggin Protein
chemical_list: D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D018076:DNA, Complementary; D006133:Growth Substances; D018398:Homeodomain Proteins; D011506:Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; D000099176:Noggin Protein; C099992:ventx2.1 protein, Xenopus