1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene in rats.
The effects of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene (DMBA) were investigated in rats. Daily oral administration of UFT reduced the incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymidine kinase, and a reduction of bromodeoxyuridine-immunoreactive (S-phase) cells in mammary tumors of UFT-treated rats.
Sakamoto
S
S
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Kudo
H
H
Suzuki
S
S
Sassa
S
S
Yoshimura
S
S
Nakayama
T
T
Maemura
M
M
Mitamura
T
T
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000276:immunology; D005260:Female; D006728:Hormones / Q000097:blood; D007150:Immunohistochemistry; D015994:Incidence; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000453:epidemiology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D005641:Tegafur / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D013937:Thymidine Kinase / Q000187:drug effects / Q000378:metabolism; D013940:Thymidylate Synthase / Q000187:drug effects / Q000378:metabolism; D014498:Uracil / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D006728:Hormones; D005641:Tegafur; D014498:Uracil; D015127:9,10-Dimethyl-1,2-benzanthracene; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D001973:Bromodeoxyuridine