title: HLA typing and retinitis pigmentosa.
abstract: Retinitis pigmentosa is a disease whose pathogenesis remains largely obscure. A lot of evidences support the hypothesis that auto-immunity is involved, but no HLA antigen has ever been associated with retinitis pigmentosa. Ten patients with autosomal recessive retinitis pigmentosa were tissue typed for class I and II HLA antigens. The results of the study show a significant increase in the frequency of the antigens Cw4, Cw6 and DR11. High values of relative risk were found also for some class I antigens, but the size of the group of patients with these loci precluded a meaningful statistical analysis.
authors: Institute of Ophthalmology, University of Messina, Italy.
authors: I
authors: I
authors: Castagna
authors: F
authors: F
authors: Famà
authors: G
authors: G
authors: Pettinato
authors: F
authors: F
authors: Palamara
authors: C J
authors: CJ
authors: Trombetta
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D003627:Data Interpretation, Statistical; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D008297:Male; D008858:Microscopy, Phase-Contrast; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D006680:HLA Antigens