Postnatal development of the human primary motor cortex: a quantitative cytoarchitectonic analysis.
The postnatal development of the human primary motor cortex (area 4) was analyzed in 54 individuals ranging in age from birth to 90 years. Three parameters defining major cytoarchitectonic features (areal fraction, numerical density and mean area of cells) were measured in vertical columns extending from the pial surface to the border between cortex and underlying white matter. The data were compiled in profile curves that reveal or more detailed laminar pattern than the classical cytoarchitectonic descriptions. The most pronounced decreases in numerical density and areal fraction of Nissl-stained cells profiles during early postnatal ontogeny are observed in layer II. A clearly delineable layer IV, which is still recognizable in the newborn, disappears gradually during the first postnatal months. Although the width of the cortex as a whole increases during this period, layer V, the main source of pyramidal tract fibers, is the only lamina that also increases in relative thickness. The other layers remain stable or become relatively thinner. These results reveal specific laminar growth processes in area 4, which take place in parallel with the functional maturation of the cortical motor system.
Amunts
K
K
C.&O. Vogt Brain Research Institute, Heinrich Heine University Düsseldorf, Germany.
Istomin
V
V
Schleicher
A
A
Zilles
K
K
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D048429:Cell Size; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000166:cytology* / Q000254:growth & development*