[Adverse reactions to different types of influenza vaccines].
BACKGROUND
The objective was to establish the rate of adverse reactions to the various influenza vaccines (whole, fractionated and subunits).


METHODS
The prescription and the adverse reactions to 21,391 influenza vaccinations carried out in the Avila province, Spain, were studied using a questionnaire filled in at the moment when the vaccine was administered and one or two weeks afterwards. The statistical tests used were the residual chi 2 and the multivariate logistic regression analysis.


RESULTS
Adverse reactions were observed in 28.8% of the cases. Local pain (18.8%) and redness (13.4%) were the most frequent reactions. 3% of the vaccinated people had fever, 4.9% general malaise and 1.2% were confined in bed. Other adverse reactions were observed in 5.4% of the persons. The differences between the various vaccines were significant (whole vaccines with a rank, according to the trademark, 27.7% to 35.8%; fractionated, 27.3% and subunits, 24.4%).


CONCLUSIONS
Inactivated whole and fractionated vaccines cause more adverse reactions, mainly local, than subunit vaccines. There are no differences in adverse sistemic reactions. Occupational prescription and vaccines administered to persons older than 65 were the lowest risk prescriptions.
Bernad Valles
M
M
Unidad Docente de Medicina Familiar y Comunitaria, Gerencia de Atención Primaria de Avila, INSALUD.
Núñez Mateos
J C
JC
Castillo Soria
O
O
González Manjavacas
M C
MC
García Serna
B
B
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio
D007252:Influenza Vaccines
Reacciones adversas con diferentes tipos de vacuna antigripal.