Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients.
In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet-poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.
Nilsson
C
C
Department of Neurochemistry, University of Göteborg, Mölndal, Sweden.
Karlsson
G
G
Blennow
K
K
Heilig
M
M
Ekman
R
R
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003863:Depression / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood* / Q000276:immunology; D011863:Radioimmunoassay
D009478:Neuropeptide Y