[The relationship between placental pathology and certain pathogens detected in paraffin-embedded tissues in cases of intrauterine growth retardation].
OBJECTIVE
To study the relationship between placental pathology and certain pathogens detected in paraffin-embedded placental tissues in cases of intrauterine growth retardation (IUGR).


METHODS
The PCR-DNA techniques were used for determination of pathogens, including toxoplasma, cytomegalovirus and herps simplex type II in paraffin-embedded placental tissues from 53 cases of IUGR.


RESULTS
Among 53 cases of IUGR, the pathogens were detected in 19 cases (35.85%). The relationships of pathogens detected to placental pathology were analyzed. Pathogens were found in 10 of 18 placentas with villitis, 7 of 11 placentas with villous maturation retarded and 2 of 3 intervillous space infections respectively. The incidence of infection in the pathological placentas was 59.38%.


CONCLUSIONS
The study suggested that the haematogenous infections could play important roles in unknown causes of IUGR.
Liu
B
B
Shanghai Sixth People's Hospital.
Tao
W
W
Liu
D
D
D000328:Adult; D000818:Animals; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections; D005260:Female; D005317:Fetal Growth Retardation; D006558:Herpes Genitalis; D018258:Herpesvirus 2, Human / Q000302:isolation & purification; D006801:Humans; D010920:Placenta / Q000469:parasitology / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012189:Retrospective Studies; D014122:Toxoplasma / Q000302:isolation & purification; D014123:Toxoplasmosis