Lymphangiosarcoma in a young dog.
Lymphangiosarcoma was diagnosed from biopsy material obtained from an 8-week-old puppy with a progressively enlarging subcutaneous inguinal swelling. Histologically, the tumor was composed of endothelial cells immediately adjacent to large collagen bundles. Tumor cells formed irregular vascular channels which extended along the connective tissue investments of small vessels and nerves of the subcutis and deep dermis. Similar neoplastic tissue extensively infiltrated an inguinal lymph node. Neoplastic cells were immunohistochemically stained for factor 8-related antigen and were weakly positive when compared with several hemangiomas and hemangiosarcomas. Transmission electron microscopy revealed numerous micropinocytotic vesicles and a continuous basal lamina. The puppy was euthanatized at 8 months of age due to severe septic polyarthritis. Lymphangiosarcoma was documented at the site of the original tumor as well as in the axillary lymph node at necropsy.
Sagartz
J E
JE
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210, USA.
Lairmore
M D
MD
Haines
D
D
Sheafor
S E
SE
Couto
C G
CG
D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004283:Dog Diseases / Q000276:immunology / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D008204:Lymphangiosarcoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D014841:von Willebrand Factor / Q000032:analysis
D014841:von Willebrand Factor