title: Protein F1/GAP-43 and PKC gene expression patterns in hippocampus are altered 1-2 h after LTP.
abstract: Three days after long-term potentiation (LTP) there is a decrease in the gene expression of protein F1 (GAP-43) and gamma-PKC in CA3 pyramidal cells that is correlated with the magnitude of LTP. We predicted these decreases would be preceded by an increment in gene expression. At 1 h, but not at 2 h after LTP, F1/GAP-43 and gamma-PKC mRNA hybridization were increased, but increases were also observed after control stimulation. At both 1 and 2 h after LTP, changes in F1/GAP-43 hybridization were positively correlated with gamma-PKC hybridization and negatively correlated with LTP magnitude. These data indicate that correlated alterations in F1/GAP-43 gene expression and synaptic efficacy can occur as early as 1 h after LTP and persist for days.
authors: Cresap Neuroscience Laboratory, Northwestern University, Evanston, IL 60208, USA.
authors: P J
authors: PJ
authors: Meberg
authors: E G
authors: EG
authors: Valcourt
authors: A
authors: A
authors: Routtenberg
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D019922:GAP-43 Protein; D005786:Gene Expression Regulation / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D017774:Long-Term Potentiation; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011493:Protein Kinase C / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011493:Protein Kinase C