title: Stereoselective pharmacokinetics of mefloquine in young children.
abstract: OBJECTIVE
  the stereospecificity of mefloquine pharmacokinetics in children has been investigated.
  
  
  METHODS
  Twelve children aged 6 to 24 months were treated for uncomplicated falciparum malaria with a single oral dose of 25 mg.kg-1 racemic mefloquine in combination with sulfadoxine and pyrimethamine.
  
  
  METHODS
  concentrations of mefloquine enantiomers were determined using a coupled achiral-chiral chromatographic system. Pharmacokinetic parameters were calculated using model-independent analysis.
  
  
  RESULTS
  Maximum plasma concentrations, areas under the curve and apparent plasma elimination half-lives were higher for the (-) enantiomer than its antipode. In contrast, the apparent volume of distribution (V/f) and total clearance (Cl/f) values were higher for the (+) enantiomer.
  
  
  CONCLUSIONS
  the stereoselectivity of mefloquine pharmacokinetics is similar to that observed in adults.
authors: Hôpital Pitie Salpetriere Service Pharmacie 47, Paris, France.
authors: A
authors: A
authors: Bourahla
authors: C
authors: C
authors: Martin
authors: F
authors: F
authors: Gimenez
authors: V
authors: V
authors: Singhasivanon
authors: P
authors: P
authors: Attanath
authors: A
authors: A
authors: Sabchearon
authors: T
authors: T
authors: Chongsuphajaisiddhi
authors: R
authors: R
authors: Farinotti
mesh_terms: D000962:Antimalarials / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006207:Half-Life; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy; D015767:Mefloquine / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013237:Stereoisomerism; D013785:Thailand
chemical_list: D000962:Antimalarials; D015767:Mefloquine