Effects of phencyclidine metabolites on serotonin uptake in rat brain.
The effects of phencyclidine (PCP) and its metabolites on serotonin (5-hydroxytryptamine, 5-HT) receptors were studied. PCP and its metabolites inhibited the uptake of [3H]5-HT and the binding of [3H]paroxetine in rat brain, while they failed to inhibit either [3H]5-HT binding to 5-HT1 receptors or [3H]ketanserin binding to 5-HT2 receptors. The trans-isomer of 4-phenyl-4-(I-piperidinyl)cyclo-hexanol (trans-4-PPC), the major metabolite of PCP, rather than PCP itself, inhibited [3H]5-HT uptake most potently. These results suggest that the serotonergic effects of PCP, in part, may be based on the effects of PCP metabolites on 5-HT uptake.
Hori
T
T
Department of Psychiatry, University of Tsukuba, Ibarak, Japan.
Suzuki
T
T
Baba
A
A
Abe
S
S
Yamamoto
T
T
Moroji
T
T
Shiraishi
H
H
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D017374:Paroxetine / Q000378:metabolism; D010622:Phencyclidine / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D007650:Ketanserin; D017374:Paroxetine; D010622:Phencyclidine; D011985:Receptors, Serotonin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors