Osteocalcin, growth, and inhaled corticosteroids: a prospective study.
OBJECTIVE
To determine the relationship between biochemical markers of bone metabolism and statural growth, and their suitability as surrogate markers of inhaled corticosteroid induced growth suppression.


METHODS
Randomised, double blind, placebo controlled comparison of inhaled beclomethasone dipropionate 200 micrograms twice daily as dry powder for six months.


METHODS
Southampton.


METHODS
Serum osteocalcin, urinary deoxypyridinoline, and statural growth.


METHODS
7 to 9 year old children with recurrent wheeze.


RESULTS
There were no significant differences in serum osteocalcin between the beclomethasone dipropionate and placebo group measured at baseline or after three and six months' treatment, while deoxy-pyridinoline was significantly higher in the placebo treated children after three months. Growth was significantly decreased in the beclomethasone dipropionate group over the course of the study. Growth over the six months, both in those receiving beclomethasone dipropionate and those receiving placebo, was significantly correlated with serum osteocalcin measured at three months and six months.


CONCLUSIONS
Although serum osteocalcin shows excellent correlation with growth, it is a poor marker for decreased growth associated with use of inhaled corticosteroids.
Doull
I
I
University of Medicine, Southampton General Hospital.
Freezer
N
N
Holgate
S
S
D000280:Administration, Inhalation; D000287:Administration, Topical; D000596:Amino Acids / Q000652:urine; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002648:Child; D003404:Creatinine / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D011446:Prospective Studies
D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D005938:Glucocorticoids; D015675:Osteocalcin; C036020:deoxypyridinoline; D003404:Creatinine; D001507:Beclomethasone