Psoriasin: a novel chemotactic protein.
Inflammatory skin disorders such as psoriasis show a preferential epidermal infiltration of neutrophils and T lymphocytes. This observation raises a question as to which factors determine the appearance and composition of leukocyte tissue infiltrations. Previously, we described a low molecular mass calcium-binding protein (psoriasin, molecular mass 11,457 Da, pI 6.77) belonging to the S1OO family that is highly upregulated in psoriatic keratinocytes and whose expression patterns implied a role in the inflammatory response. Here we report that human psoriasin is a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes and neutrophils at concentrations of about 10(-11) M. Psoriasin is not structurally related to the alpha or the beta chemokine subfamilies or to lymphotactin, a member of a newly described class of chemokines. Thus, we have observed a chemotactic protein outside the chemokine subfamilies that could be an important new inflammatory mediator.
Jinquan
T
T
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Vorum
H
H
Larsen
C G
CG
Madsen
P
P
Rasmussen
H H
HH
Gesser
B
B
Etzerodt
M
M
Honoré
B
B
Celis
J E
JE
Thestrup-Pedersen
K
K
D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002630:Chemotactic Factors / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000502:physiology; D011994:Recombinant Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; D013601:T-Lymphocytes / Q000502:physiology
D002135:Calcium-Binding Proteins; D002630:Chemotactic Factors; D011994:Recombinant Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human; D003094:Collagen