[The effect of blockade of the AMPA/kainate receptors of the nucleus accumbens on synaptic dopamine release during an emotional conditioned response].
In vivo microdialysis combined with HPLC-EC analysis was used to monitor extracellular dopamine in the medial nucleus accumbens of rats. A conditioned emotional response to a contextual cue was accompanied by a prolonged release of dopamine in the nucleus accumbens. AMPA/kainate antagonist CNQX (100 mcM, intra-accumbens) had no effect on the conditioned dopamine release during the conditioned emotional responses. The data indicate that AMPA/kainate receptors of the nucleus accumbens are not involved in the regulation of the conditioned dopamine release.
Saul'skaia
N B
NB
Marsden
Ch A
ChA
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008297:Male; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000502:physiology; D018092:Kainic Acid Receptors / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D004298:Dopamine; D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors
Vliianie blokady AMPA/kainatnykh retseptorov prilezhashchego iadra na sinapticheskiĭ vybros dofamina v khode émotsional'nogo uslovnogo otveta.