Circulation of poliovirus among risk groups in Ibadan, Nigeria.
Faecal samples collected from 114 fully vaccinated pre-school children and 32 unvaccinated infants in Ibadan, Nigeria, were assayed for poliovirus in Hep-2 and RD cell cultures. 8 strains of poliovirus type 1 were isolated from 146 samples--3 from 32 unvaccinated children aged less than 40 d and 5 from 114 fully vaccinated children aged between 9 and 60 months. Studies using Sabin and wild monoclonal antibodies and the polymerase chain reaction confirmed 7 of the 8 isolates to be of the wild type, a possible source of infection among vaccinated children.
Adu
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FD
Department of Virology, University of Ibadan, Nigeria.
Odemuyiwa
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SO
Tomori
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D002675:Child, Preschool; D005243:Feces / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria; D011051:Poliomyelitis / Q000517:prevention & control; D017955:Poliovirus / Q000302:isolation & purification*; D014611:Vaccination