Receptors for glucocorticoids in the human inner ear.
Glucocorticoid receptors were detected in the human inner ear. The highest concentration of glucocorticoid receptor protein was measured by enzyme-linked immunosorbent assay in the spiral ligament tissues; the lowest concentration of glucocorticoid receptors was measured in the macula of the saccule. The demonstration of the presence of glucocorticoid receptors in human Inner ear tissues provides a basis to consider the direct effects of glucocorticoid action on select inner ear cells, rather than assuming a systemic antiinflammatory or immunosuppressive effect during the therapeutic treatment of patients with given inner ear disorders.
Rarey
K E
KE
Department of Anatomy, College of Medicine, University of Florida, Gainesville, 32610, USA.
Curtis
L M
LM
D008267:Acoustic Maculae / Q000737:chemistry; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003051:Cochlea / Q000737:chemistry; D003053:Cochlear Duct / Q000737:chemistry; D007758:Ear, Inner / Q000737:chemistry* / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D009925:Organ of Corti / Q000737:chemistry; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D012444:Saccule and Utricle / Q000737:chemistry; D012665:Semicircular Canals / Q000737:chemistry; D013256:Steroids; D013316:Stria Vascularis / Q000737:chemistry; D014722:Vestibule, Labyrinth / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011965:Receptors, Glucocorticoid; D013256:Steroids