title: Cytokine regulation of monocyte recruitment.
abstract: Phagocytes infiltrating neoplastic tissues have peculiar membrane phenotype and functional properties. Tumor-associated macrophages (TAM) play a complex, ambiguous role in the regulation of primary tumor growth and metastasis (a "macrophage balance"). Yet these cells are strategically located at the very interface between tumor and host and represent a potential target for immunomodulation. A better understanding of the regulation and function of TAM may provide a less empirical basis of or rational design of therapeutic approaches, as vividly illustrated by the antitumor activity of i.p. in IFN ovarian cancer patients with minimal residual disease resistant to chemotherapy.
authors: Institute of Pharmacological Research Mario Negri, Milano, Italy.
authors: A
authors: A
authors: Mantovani
authors: B
authors: B
authors: Bottazzi
authors: S
authors: S
authors: Sozzani
authors: G
authors: G
authors: Peri
authors: P
authors: P
authors: Allavena
authors: Q G
authors: QG
authors: Dong
authors: A
authors: A
authors: Vecchi
authors: F
authors: F
authors: Colotta
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000276:immunology; D015846:Monokines / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000628:therapy
chemical_list: D016207:Cytokines; D015846:Monokines