The reactions of euthyroid and hyperthyroid glands to radioactive iodine.
BACKGROUND
Researchers generally assume that the thyroid gland reacts more or less comparably to external irradiation and radioactive iodine.


METHODS
The thyroid glands from 20 euthyroid patients and 20 hyperthyroid patients, all of which had been treated with radioactive iodine, were studied.


RESULTS
The two groups manifested different reactions. Almost all the euthyroid glands displayed a fibrotic atrophic pattern, whereas the glands from the Graves' disease patients showed more adenomatous and Hashimoto lesions than atrophy.


CONCLUSIONS
Differences in the reactivity of normal and hyperplastic follicles may cause different reactions to treatment with radioactive iodine.
Friedman
N B
NB
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048-1869, USA.
Catz
B
B
D000236:Adenoma / Q000209:etiology / Q000473:pathology; D000787:Angina Pectoris / Q000532:radiotherapy; D002277:Carcinoma / Q000209:etiology / Q000473:pathology; D005355:Fibrosis / Q000209:etiology / Q000473:pathology; D006042:Goiter / Q000473:pathology / Q000532:radiotherapy*; D006111:Graves Disease / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D006980:Hyperthyroidism / Q000473:pathology / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D008679:Metaplasia / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D009929:Organ Size / Q000528:radiation effects; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects*; D016606:Thyroid Nodule / Q000209:etiology* / Q000473:pathology
D007457:Iodine Radioisotopes