A model for pharmacological research-treatment of cocaine dependence.
Major problems for research on pharmacological treatments for cocaine dependence are lack of comparability of results from different treatment research programs and poor validity and/or reliability of results. Double-blind, placebo-controlled, random assignment, experimental designs, using standard intake and assessment procedures help to reduce these problems. Cessation or reduction of drug use and/or craving, retention in treatment, and medical and psychosocial improvement are some of the outcome variables collected in treatment research programs. A model to be followed across different outpatient clinical trials for pharmacological treatment of cocaine dependence is presented here. This model represents an effort to standardize data collection to make results more valid and comparable.
Montoya
I D
ID
National Institutes of Health, National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224, USA.
Hess
J M
JM
Preston
K L
KL
Gorelick
D A
DA
D003042:Cocaine; D004311:Double-Blind Method; D006801:Humans; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D019966:Substance-Related Disorders / Q000534:rehabilitation*; D016896:Treatment Outcome
D011619:Psychotropic Drugs; D003042:Cocaine