Cytarabine release from alpha, beta-poly (N-hydroxyethyl)-DL-aspartamide matrices cross-linked through gamma-radiation.
alpha, beta-Poly (N-hydroxyethyl)-DL-aspartamide solutions were cross-linked through gamma-radiation and the systems obtained were tested as matrices for drug sustained release, using cytarabine as model drug. We performed the characterization of the cross-linked polymer, both drug-loaded and unloaded. through water swelling measurements, scanning electron microscopy and X-ray analysis. Finally, we investigated the in vitro release behaviour of cytarabine.
Spadaro
G
G
Dipartimento di Ingegneria Chimica dei Processi e Materiali, Università di Palermo, Palermo, Italy.
Dispenza
C
C
Giammona
G
G
Pitarresi
G
G
Cavallaro
G
G
D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents / Q000737:chemistry; D003561:Cytarabine / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005720:Gamma Rays; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010455:Peptides / Q000737:chemistry*; D012996:Solutions; D014961:X-Ray Diffraction
D003432:Cross-Linking Reagents; D004337:Drug Carriers; D010455:Peptides; D012996:Solutions; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); D003561:Cytarabine