Diuretic and natriuretic effects of chromatographically purified fraction of garlic (Allium sativum).
The intravenous administration of chromatographically purified fractions of garlic (2, 4 and 6 micrograms/kg dry weight) to anaesthetized rabbits elicits dose-dependent diuretic-natriuretic responses which reach a maximum 60 min after injection, and return to basal levels after 90 min. A gradual decrease in heart rate, but not in arterial blood pressure was observed during the course of the experimental periods. The electrocardiogram was not affected.
Pantoja
C V
CV
Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, Chile.
Norris
B C
BC
Contreras
C M
CM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D005737:Garlic / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D011817:Rabbits
D010936:Plant Extracts