Glomerular filtration rate in primary Sjögren's syndrome with renal disease.
Renal disease in Primary Sjögren's syndrome (SS) is often overlooked, because of a paucity of symptoms. Distal renal tubular acidosis (dRTA) and tubulointerstitial nephritis (TIN) might be present. Only a few cases of SS with decreased glomerular filtration rate (GFR) have been reported. We have studied GFR in 27 female SS-patients, mean age 62 years (37-78). GFR was measured as the single injection 51Cr-EDTA plasma clearance. Eighteen women had normal GFR (group 1), and nine (33%) had values below the lower normal limit (group 2). In group 2, dRTA was present in 8/9 urolithiasis in 6/9, previous upper urinary tract infection (UTI) in 2/9 and TIN in 5/6 patients who were kidney biopsied. Among patients with dRTA 8/18 (44%) had decreased GFR. We conclude that decreased GFR is not unusual in SS-patients with dRTA, and decreased GFR is mostly associated with TIN. Urolithiasis and UTI may contribute to decreased GFR in some individuals.
Eriksson
P
P
Department of Medicine, Hospital of Jönköping, Sweden.
Denneberg
T
T
Granerus
G
G
Lindström
F
F
D000141:Acidosis, Renal Tubular / Q000175:diagnosis / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007669:Kidney Calculi / Q000175:diagnosis / Q000503:physiopathology; D007677:Kidney Function Tests; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000503:physiopathology*; D012016:Reference Values; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000503:physiopathology*