Obstetric outcome of pregnancies resulting from embryos biopsied for pre-implantation diagnosis of inherited disease.
OBJECTIVE
Pre-implantation diagnosis of inherited disease is now a viable option for some couples at risk of transmitting inherited disorders to their children. Since the pregnancy begins knowing that the embryo is not at risk, the need for repeated terminations is eliminated. Up to 25% of the embryo is removed during the procedure, and so it is important to study the resulting pregnancies. Here we report on the obstetric outcome of our first 16 pregnancies resulting from embryo biopsy and preimplantation diagnosis of inherited disease.


METHODS
Teaching hospital.


METHODS
The first 16 pregnancies (12 singletons and 4 twins) following pre-implantation diagnosis.


RESULTS
Three singleton pregnancies were lost in the first trimester. Of the remaining pregnancies, two had no prenatal diagnosis, six cases of X-linked disease had the sex confirmed by ultrasound and chorionic villus sampling was performed in the remaining five. All the singleton pregnancies had an uneventful antenatal course and the birthweights and Apgar scores of the babies were normal. The twin pregnancies presented obstetric complications but these were not unusual.


CONCLUSIONS
Fifteen healthy infants were born, but for the foreseeable future pre-implantation diagnosis pregnancies should be closely followed up.
Soussis
I
I
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Harper
J C
JC
Handyside
A H
AH
Winston
R M
RM
D001706:Biopsy; D001755:Blastocyst; D006063:Chorionic Gonadotropin / Q000097:blood; D047108:Embryonic Development; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D005865:Gestational Age; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods*; D014427:Twins
D006063:Chorionic Gonadotropin