title: DNA amplification on chromosome 3q26.1-q26.3 in squamous cell carcinoma of the lung detected by reverse chromosome painting.
abstract: Multiple genetic lesions have been reported in small cell lung carcinoma (SCLC), while considerably less information is available on squamous cell carcinoma (SCC). We used reverse chromosome painting to screen a total of nine SCCs for DNA amplifications. In three of the nine SCCs, hybridisation signals were found at chromosome region 3q26.1-q26.3, which does not contain any known oncogene. In one of the three SCCs, there were additional hybridisation signals at 1q, 5p and 6p21.1. The high frequency of a consistent amplification (3q26.1-q26.3) in SCC strongly indicates a novel gene at 3q26.1-q26.3 that is important in the pathology of SCC.
authors: Institut für Humangenetik, Universität des Saarlandes, Homburg/Saar, Germany.
authors: N
authors: N
authors: Brass
authors: I
authors: I
authors: Ukena
authors: K
authors: K
authors: Remberger
authors: U
authors: U
authors: Mack
authors: G W
authors: GW
authors: Sybrecht
authors: E U
authors: EU
authors: Meese
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D004273:DNA, Neoplasm / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D004273:DNA, Neoplasm