Isolated leukemia cutis and CNS involvement in combination with cytogenetic findings of trisomy 8--two case reports.
We describe two patients who showed a very similar, but atypical course of acute myelogenous leukemia. They demonstrated skin nodules, spinal fluid and CNS involvement whereas bone marrow and blood remained clear. Nonetheless both had cytogenetic findings of trisomy 8 in the marrow and were resistant to a combination of cytarabine, idarubicin, fludarabine, and granulocyte-colony stimulating factor.
Kuschel
B
B
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Estey
E
E
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000473:pathology*; D002898:Chromosomes, Human, Pair 8; D003561:Cytarabine / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D014314:Trisomy; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
D003561:Cytarabine; D016179:Granulocyte Colony-Stimulating Factor; D014740:Vidarabine; C024352:fludarabine; D015255:Idarubicin