[The effect of intrathecal injection of neurotensin on acupuncture analgesia in rats].
The influence of intrathecal injection of Neurotensin (NT) and Anti-NT serum (ANTS) on pain threshold, and electroacupuncture (EA) analgesia in the rat was investigated. The tail-flick induced by potassium iontophoresis was used to measure the pain threshold. The increase of pain threshold was observed within 100 min, after NT injection (2 micrograms), and it was more effective than that of the ACSF injection (P < 0.01). The NT administration could also enhance the EA analgesia. On the contrary, the pain threshold was decreased in ANTS group as compared with that of ACSF control group. The ANTS administration could decreased the role of EA analgesia. Our data show that NT in spinal cord may play an important role in the EA analgesia.
Liu
W
W
Dept. of Physiology, Jining Medical College, Jining City.
Bai
B
B
Wang
H
H
Song
C
C
Lin
B
B
D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D005260:Female; D007278:Injections, Spinal; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D009496:Neurotensin