Frequency of neuropathology in a brain bank from a long-term, domiciliary population.
Postmortem analysis of brain chemistry and anatomy in the study of psychiatric disorders has enjoyed renewed interest recently. There are myriad difficulties in establishing a brain bank, including proper diagnosis and confounding neuropathology. These difficulties may become more pronounced in a long-term domiciliary facility. In order to begin to address neuropathologic considerations, we performed neuropathological examinations on each patient included in our bank of 20 brains. Forty-five per cent of all patients had significant and unexpected neuropathology. Selection of patients to be included in postmortem studies requires careful screening to enhance accurate neuropathological assessment.
Healy
D J
DJ
Mental Health Research Institute, Ann Arbor, MI 48109, USA.
Sima
A A
AA
Tapp
A
A
Watson
S J
SJ
Meador-Woodruff
J H
JH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D001925:Brain Damage, Chronic / Q000473:pathology*; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000473:pathology; D012559:Schizophrenia / Q000473:pathology*; D014015:Tissue Banks