title: Electrolyte content of serum, erythrocyte, kidney and heart tissue in salt induced hypertensive rats.
abstract: The effect of salt load on the systolic blood pressure (SBP) and electrolyte levels of serum, erythrocyte, kidney and heart tissue was studied in rats. NaCl treatment increased sodium (5.69 +/- 0.4 mmol/L p < 0.001, 149.8 +/- 4.0 mEq/L, p < 0.001) and decreased potassium (112.6 +/- 2.4 mmol/L p < 0.001, 5.0 +/- 0.2 mEq/L, p < 0.001) in red cell and serum respectively. A decreased level of serum magnesium (1.4 +/- 0.3 mEq/L, p < 0.005) was observed. Sodium content was increased in both heart (39.93 +/- 2.9 mumol/g, p = n.s) and kidney tissues (44.39 +/- 0.5 mumol/g, p < 0.001). A pronounced increase in intracellular calcium (2.54 +/- 0.2 mumol/g, p < 0.001) and a decrease of magnesium content (6.05 +/- 0.8 mumol/g, p < 0.001) was observed in kidney tissue after treatment. The results suggested that marked changes in electrolyte levels of erythrocytes, serum, heart and kidney tissues in NaCl loaded rats may play a definite role in the development of salt induced hypertension.
authors: Department of Biochemistry, University of Karachi, Pakistan.
authors: T
authors: T
authors: Mahboob
authors: M
authors: M
authors: Mumtaz
authors: M A
authors: MA
authors: Haleem
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism; D004573:Electrolytes / Q000097:blood / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride
chemical_list: D004573:Electrolytes; D012965:Sodium Chloride; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium