99mTc-MIBI scintigraphy in metastatic renal cell carcinoma: clinical validation of the relationship between 99mTc-MIBI uptake and P-glycoprotein expression in tumour tissue.
Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) and thallium-201 imaging was performed in a patient with metastatic renal cell carcinoma (RCC), which is a well-known tumour type demonstrating P1-glycoprotein (PGP) overexpression. Two scintigraphic patterns - Tl(+)/MIBI(-) in primary tumour and Tl(+)/MIBI(+) in metastatic tumour - were observed, suggesting high- and low-level PGP expression, respectively. Immunochemical study for PGP revealed strong staining of the primary tumour cells. This case clinically validates the previously suggested relationship between 99mTc-MIBI uptake and PGP expression.
Derebek
E
E
Department of Nuclear Medicine, School of Medicine, Dokuz Eylül University, Izmir, Turkey.
Kirkali
Z
Z
Dogan
A S
AS
Degirmenci
B
B
Yilmaz
M
M
Igci
E
E
Yorukoglu
K
K
Kovanlikaya
I
I
Durak
H
H
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000235:genetics / Q000556:secondary*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000556:secondary*; D008297:Male; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi