title: Dynamic MRI sensitized to cerebral blood oxygenation and flow during sustained activation of human visual cortex.
abstract: Changes in cerebral blood oxygenation and flow during prolonged activation of human visual cortex (6-min video projection) were monitored using high-resolution T2*- and T1-weighted gradient-echo MRI in identical sessions. Oxygenation-sensitive recordings displayed an initial signal increase (oxygenation "overshoot"), a subsequent signal decrease extending over 4-5 min (relative deoxygenation), and a signal drop after the end of stimulation that mirrored the initial response (oxygenation "undershoot"). Flow-sensitive MRI demonstrated that the inflow effect remained elevated during the entire period of stimulation. The observation of gradually decreasing cerebral blood oxygenation, despite persisting elevation of blood flow, may be understood to be an accumulation of deoxyhemoglobin due to the progressive up-regulation of oxidative phosphorylation. The present findings support a concept in which transitions between functional states lead to an uncoupling of perfusion (oxygen delivery) from oxidative metabolism (oxygen consumption) whereas steady-state activity achieves their recoupling.
authors: Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie Am Fassberg 11, Göttingen, Germany.
authors: G
authors: G
authors: Krüger
authors: A
authors: A
authors: Kleinschmidt
authors: J
authors: J
authors: Frahm
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010775:Photic Stimulation; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*
chemical_list: D010100:Oxygen