New prenylated quinones from Peperomia galioides.
Two new prenylated quinones, piperogalone (1) and galopiperone (2), and a new prenylated dihydroquinone, hydropiperone (3), were isolated from Peperomia galioides H.B.K (Piperaceae). Hydropiperone exhibited potent antiparasitic activity against three species of Leishmania.
Mahiou
V
V
Laboratoire de Pharmacognosie, URA 1843 CNRS (BIOCIS), Faculté de Pharmacie, Université de Paris XI, Châtenay-Malabry, France.
Roblot
F
F
Hocquemiller
R
R
Cavé
A
A
Rojas De Arias
A
A
Inchausti
A
A
Yaluff
G
G
Fournet
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D001578:Benzopyrans; D011809:Quinones; C101812:galopiperone; C101811:hydropiperone; C101810:piperogalone