Expression of activin receptors type I and II only partially overlaps in the nervous system.
In situ hybridization was used to localize mRNA encoding two cooperative serine/threonine kinase receptors. Activin receptor IIA mRNA in the adult rat brain is highly expressed in the dentate gyrus, in the pyramidal neurones of CA3 and CA1, in the entorhinal cortex, in the cortical amygdaloid nucleus and in the amygdalohippocampal area. In the E16 rat embryo, labelling was found in the dorsal root ganglion neurones and in the spinal cord. Activin type I receptor (ALK-2/R-1) labelling was also localized to the hippocampal formation but with an even distribution over the granular cells of the dentate gyrus, the CA3 and CA1 pyramidal neurones, while no labelling was found in the entorhinal or amygdaloid areas. In the E16 rat no neuronal labelling was found. The incomplete overlap of these two expression patterns suggests that these receptors may locally have other partners for forming signalling receptor complexes.
Bengtsson
H
H
Department of Developmental Neuroscience, Uppsala University, Sweden.
Söderström
S
S
Ebendal
T
T
D029404:Activin Receptors; D030201:Activin Receptors, Type I; D001483:Base Sequence; D001923:Brain Chemistry / Q000502:physiology*; D006133:Growth Substances / Q000235:genetics; D006651:Histocytochemistry; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases; D012333:RNA, Messenger / Q000032:analysis*; D017978:Receptors, Growth Factor / Q000235:genetics*; D013116:Spinal Cord / Q000737:chemistry* / Q000196:embryology
D006133:Growth Substances; D012333:RNA, Messenger; D017978:Receptors, Growth Factor; D017346:Protein Serine-Threonine Kinases; D029404:Activin Receptors; D030201:Activin Receptors, Type I