Developmental expression of GAP43 mRNA in chromaffin cells and intra-adrenal neurons.
Growth associated protein 43 (GAP43) mRNA was found in scattered groups of chromaffin cells prenatally, and in chromaffin noradrenaline cells from postnatal day 6 (P6). The distinct adult distribution of GAP43 mRNA in chromaffin cells appeared between P10 and P16. High levels of GAP43 mRNA were found in intra-adrenal ganglion neurons also expressing neuropeptide tyrosine (NPY) mRNA (type I ganglion neurons), and at prenatal and early postnatal stages in large medullarly clusters of NPY mRNA containing cells, probably representing type I ganglion neurons precursors. The expression of GAP43 mRNA in noradrenaline-producing chromaffin cells and type I ganglion neurons suggests an important role for GAP43 in these cells both during development and in adult life.
Holgert
H
H
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002838:Chromaffin System / Q000378:metabolism*; D019922:GAP-43 Protein; D015870:Gene Expression; D006133:Growth Substances / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
D019922:GAP-43 Protein; D006133:Growth Substances; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger