Suppression of testicular and epididymal functions in a non-human primate (bonnet monkey) by combined administration of a gonadotropin-releasing hormone antagonist and testosterone buciclate.
The ability of a long-acting androgen, testosterone buciclate (TB), to induce suppression of testicular and epididymal sperm functions when given in combination with a potent GnRH antagonist (Antide) either on day 1 or 45 of Antide administration (days 1-90) as well as the ability of TB to maintain Antide-induced suppression of spermatogenesis were evaluated in adult bonnet monkeys. A group of untreated animals (group I) acted as controls. All animals given Antide and androgen simultaneously (group II) became azoospermic but at different times. When androgen administration was delayed 45 days after start of Antide treatment (group III), the mean sperm concentration remained in the normospermic range and only three animals became azoospermic. Antide given alone (group IV) induced azoospermia in three animals and oligospermia in the remaining animals; spermatogenesis recovered when Antide was withdrawn and TB was injected. In all Antide-treated animals (groups II-IV), non-motile spermatozoa or sperm with non-progressive motility and poor gel penetrability were seen in the ejaculate.
Rajalakshmi
M
M
Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
Kumar
P K
PK
Kinger
S
S
Pal
P C
PC
Pruthi
J S
JS
Bajaj
J S
JS
D000818:Animals; D001835:Body Weight; D003272:Contraceptive Agents, Male / Q000008:administration & dosage*; D004542:Ejaculation / Q000187:drug effects; D004822:Epididymis / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000008:administration & dosage*; D008255:Macaca radiata; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage*; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood
D003272:Contraceptive Agents, Male; D006727:Hormone Antagonists; D009842:Oligopeptides; C050320:testosterone 4-n-butylcyclohexylcarboxylic acid; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C057022:iturelix