A retrospective evaluation of adverse reactions to trimethoprim-sulphonamide combinations in dogs and cats.
Adverse reactions to various trimethoprim-sulphonamide (T-S) combinations were studied retrospectively in dogs and cats referred to the Utrecht University Department of Clinical Sciences of Companion Animals during the period 1985-1994. Dermatological and systemic reactions were observed in 19 dogs and 2 cats. Specific histological reaction patterns were seen in 3 dogs with toxic epidermal necrolysis, in 1 dog and 1 cat with erythema multiforme, and in 1 dog with pemphigus foliaceus. Diagnostic criteria used in humans proved to be reliable in dogs and cats as well. Adverse reactions were observed within 7-14 days after administration and were most often due to sulphadiazine (76%) and sulphatroxazole (14%). The incidence of adverse reactions to T-S was 0.25%.
Noli
C
C
Faculty of Veterinary Medicine, University of Utrecht, Department of Clinical Sciences of Companion Animals, The Netherlands.
Koeman
J P
JP
Willemse
T
T
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002371:Cat Diseases / Q000139:chemically induced*; D002415:Cats; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology / Q000662:veterinary*; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D005500:Follow-Up Studies; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D004338:Drug Combinations; D013449:Sulfonamides; D014295:Trimethoprim