Effects of granulocyte colony-stimulating factor on the hemostatic system in healthy volunteers.
We previously identified a receptor for granulocyte colony-stimulating factor (G-CSFR) on platelet membranes, and reported that G-CSF enhanced ADP-induced platelet aggregation. Here, we investigated the priming effect of G-CSF on the hemostatic system in healthy volunteers given G-CSF. Following the administration of rhG-CSF (10 micrograms/kg for 30 min div) to 10 healthy volunteers, we found a significant elevation in the maximum platelet aggregation rate induced by ADP or collagen, thromboxane B2 level and amount of thrombin-antithrombin III complex. The D-D dimer and plasminogen activator inhibitor-1 showed no significant changes. These observations indicate that G-CSF administration may induce hypercoagulability in susceptible subjects. Therefore, patients or donors at risk of thrombosis or hypercoagulable state should be followed carefully after G-CSF administration.
Kuroiwa
M
M
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Okamura
T
T
Kanaji
T
T
Okamura
S
S
Harada
M
M
Niho
Y
Y
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D003094:Collagen / Q000494:pharmacology; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects; D011994:Recombinant Proteins / Q000009:adverse effects / Q000494:pharmacology; D013927:Thrombosis / Q000139:chemically induced; D013929:Thromboxane B2 / Q000097:blood
D011994:Recombinant Proteins; C046193:antithrombin III-protease complex; D016179:Granulocyte Colony-Stimulating Factor; D013929:Thromboxane B2; D000244:Adenosine Diphosphate; D000990:Antithrombin III; D003094:Collagen; D010447:Peptide Hydrolases; D000069585:Filgrastim