[Subtypes of glutamate receptor and their distribution in the somatic membrane of neurons freshly isolated from rat DRG].
The aim of the present study was to investigate the distribution and coexistence of glutamate (Glu) receptor subtypes in the isolated rat DRG neurons as identified by the recorded NMDA-, KA- or QA/AMPA-activated current using whole-cell patch-clamp technique. Of the 37 identified neurons, 15 contain only a single subtype receptor, 13 with two kind subtype receptors, only 4 with all subtype receptors. With regard the frequency of occurrence of the three types of receptors, the NMDA, KA and QA/AMPA subtype were found present respectively in 26 (70.3%), 7 (18.9%) and 21 (56.8%) of the recorded cells.
Si
J Q
JQ
Research Centre of Experimental Medicine, Tongji Medical University, Wuhan.
Li
Z W
ZW
Fan
Y Z
YZ
D000818:Animals; D000831:Animals, Newborn; D005727:Ganglia, Spinal / Q000737:chemistry / Q000502:physiology*; D009474:Neurons / Q000737:chemistry; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000032:analysis; D017470:Receptors, Glutamate / Q000145:classification; D018092:Kainic Acid Receptors / Q000032:analysis; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis
D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate