title: [Muscular involvement in HIV infection].
abstract: Skeletal muscle involvement may occur at all stages of HIV-infection and represents the first manifestation of the disease in some patients. We usually classify muscle involvement in HIV-infected patients in one of the following categories: (1) HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some; (2) zidovudine myopathy, a reversible mitochondrial myopathy; (3) the HIV-wasting syndrome and other AIDS-associated cachexias; (4) opportunistic infections and tumoral infiltrations of the skeletal muscle; (5) vasculitic processes and iron pigment deposits; (6) HIV-associated myasthenia gravis and (7) rhabdomyolysis. Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome c oxidase are helpful in correct classification of a myopathy as HIV polymyositis or zidovudine myopathy.
authors: Département de Pathologie, Hôpital Henri Mondor, Créteil.
authors: R
authors: R
authors: Gherardi
authors: P
authors: P
authors: Chariot
authors: F J
authors: FJ
authors: Authier
mesh_terms: D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D009135:Muscular Diseases / Q000139:chemically induced / Q000209:etiology*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects; D015215:Zidovudine / Q000009:adverse effects
chemical_list: D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine
vernacular_title: Les atteintes musculaires au cours de l'infection par le VIH.