[H2-receptor antagonists and alcohol: clinical significance].
The aim of the review is to evaluate the putative clinical interactions between alcohol metabolism and the administration of H2-receptor antagonists. Places of the first-pass metabolism of ethanol in the body have been investigated as well. According to the in vitro experimental results the H2-receptor antagonists can inhibit the ethanol metabolism which may have clinical relevance. When low doses of alcohol (below 0.3 g/kg) are given per os, the administration of H2-receptor antagonists results in an increase in the blood ethanol concentrations. Since that challenged increase never exceeds the level of 0.3/1000 blood alcohol concentration, it has hardly any clinical or medico-legal significance.
Nemesánszky
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E
Gasztroenterológiai és Belgyógyászati Osztály, Országos Reumatológiai és Fizioterápiás Intézet, Budapest.
Csepregi
A
A
D002927:Cimetidine / Q000494:pharmacology; D015510:Clinical Medicine; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D015738:Famotidine / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000378:metabolism; D016567:Nizatidine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D010880:Piperidines; D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine; D016567:Nizatidine; C053742:roxatidine acetate
A H2-receptor blokkolók és az alkohol: klinikai következtetések.