Cerebral ischemia: pharmacological bases of drug therapy.
The cascade of reactions caused by ischemia in brain tissue is complex and not completely understood, but intensive investigation has led to convincing hypotheses. A disturbed calcium homeostasis and oxygen radicals seem to play a major role in postischemic neuronal damage. In accordance to these hypotheses drugs with different mechanisms of action have been developed. The aim of this paper is to give an overview over pathobiochemical mechanisms in cerebral ischemia and possibilities of pharmacological intervention.
Ferger
D
D
Institut für Pharmakologie and Toxikologie, Philipps-Universität, Marburg, Deutschland.
Krieglstein
J
J
D000241:Adenosine / Q000819:agonists; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004734:Energy Metabolism; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006706:Homeostasis; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D017366:Serotonin Receptor Agonists; D000241:Adenosine; D002118:Calcium