title: HLA-B27 subtypes among the Chukotka Native groups.
abstract: The purpose of this study was to assess the relative frequency of the known HLA-B27 subtypes in HLA-B27 positive Chukotka natives, which have higher frequencies of HLA-B27 (to 40%) and spondyloarthropathies (to 2%) than the Russian Caucasian population. Using oligotyping of the polymerase-chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-B27 positive individuals were successfully typed. All had HLA-B*2705, including 4 patients with Reiter's syndrome and 5 with ankylosing spondyloarthritis, except one Eskimo who had HLA-B*2702. None had HLA-B*2704, a frequent subtype in Orientals. With respect to HLA-B27 subtypes the indigenous populations from the eastern part of the Chukotka Peninsula are genetically more closely related to Caucasians than to Orientalis.
authors: Department of Epidemiology and Genetics of Rheumatic Diseases, Institute of Rheumatology of RAMS, Moscow, Russia.
authors: M Y
authors: MY
authors: Krylov
authors: J D
authors: JD
authors: Reveille
authors: L I
authors: LI
authors: Alexeeva
authors: S
authors: S
authors: Erdesz
authors: F C
authors: FC
authors: Arnett
authors: L I
authors: LI
authors: Benevolenskaya
mesh_terms: D000483:Alleles; D001483:Base Sequence; D004247:DNA / Q000032:analysis / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005091:Exons; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012426:Russia; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen; D004247:DNA