Direct radioiodination of metabolic 8-hydroxy-quinolyl-glucuronide, as a potential anti-cancer drug.
8-Hydroxy-quinolyl-glucuronide (8-HOQ-Glu) can be deglucuronidated by the beta-glucoronidase enzyme, which has an activity that is considerably high in certain kinds of cancer cell. Owing to this enzyme activity, 8-HOQ-Glu can be considered as a potential anti-cancer drug. The combination of the radiotoxicity known of 125I nuclide with the cytotoxicity of 8-hydroxy-quinoline (8-HOQ) and particularly the selective carrying of 125I into the cancer cells is the principal aim of this study. As a first step, the metabolic 8-HOQ-Glu was extracted from the urine of rabbits treated with 8-HOQ directly radioiodinated using the iodogen method. The results showed that the radioiodination was successfully realized, and its yield was found to be about 90-95%.
Unak
T
T
Department of Chemistry, Faculty of Science, Ege University, Izmir, Turkey.
Unak
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000652:urine; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000652:urine; D007457:Iodine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D011817:Rabbits
D000970:Antineoplastic Agents; D006912:Hydroxyquinolines; D007457:Iodine Radioisotopes; C056147:8-hydroxyquinoline glucuronide