Lipoprotein(a) in 505 hospitalized patients with various pathological states: correlations with cardiovascular diseases and therapies.
OBJECTIVE
Our aim was to study the lipoprotein (a) (Lp(a)) levels in various pathological states.


METHODS
This investigation was prospective and included a healthy control group.


METHODS
This study was carried out in two internal medicine and angiology services in teaching hospitals.


METHODS
505 patients were included with various diseases: 66 acute infections, 9 HIV infections, 25 cancers, 86 diabetes, 36 systemic diseases, 94 atheromatous vascular disease, 27 arterial hypertensions. A control group was composed of 21 healthy subjects.


METHODS
There was no therapeutic intervention but cardiovascular treatments were recorded.


METHODS
Serum Lp(a), total cholesterol, triglycerides, HDL-cholesterol, calculated LDL-cholesterol, apolipoproteins A-I and B were measured together with inflammatory parameters, serum creatinine, proteinuria, serum aminotransferase activity.


RESULTS
There was no difference in Lp(a) levels between controls and each patient group. However, a correlation was found in systemic diseases between Lp(a) and C reactive protein (r = 0.371, p = 0.026) or serum albumin concentration (r = 0.453, p = 0.006). In hypertension, Lp(a) correlated with serum creatinine (r = 0.420, p = 0.03). In the whole patient population, Lp(a) was correlated with cholesterol (r = 0.156, p = 0.0001), apolipoprotein B (r = 0.215, p = 0.0001), age (r = 0.108, p = 0.015), arterial events (r = 0.174, p = 0.0001) and platelet anti-aggregant drugs (r = 0.169, p = 0.0001).


CONCLUSIONS
Lp(a), was related to atheromatous events and in systemic diseases to inflammation, suggesting that Lp(a) might vary in some patients in a manner similar to acute phase proteins.
Constans
J
J
Service de Médecine Interne et Pathologie Vasculaire, Hôpital Saint-André, Bordeaux, France.
Wendling
G
G
Peuchant
E
E
Camilleri
G
G
Conri
C
C
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D007239:Infections / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood; D011446:Prospective Studies
D001055:Apolipoproteins B; D017270:Lipoprotein(a); D002784:Cholesterol