Corticotropin-releasing factor induction in rat piriform cortex following kainate-elicited seizures.
There is a substantial increase in number of cells labeled for corticotropin-releasing factor-like immunoreactivity in specific extrahypothalamic brain regions, particularly the piriform cortex, in rats allowed to survive 24 h following generalized clonic seizures. Seizures were elicited by kainic acid. Vehicle treated control animals had only a few cells labeled for corticotropin-releasing factor-like immunoreactivity at these brain sites. These areas of corticotropin-releasing factor-like induction appear to be localized to brain regions known to be vulnerable to kainate neurotoxicity and cell destruction.
Piekut
D T
DT
Department of Neurobiology and Anatomy, University of Rochester School of Medicine, NY 14642, USA.
Phipps
B
B
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000032:analysis / Q000096:biosynthesis*; D003429:Cross Reactions; D007150:Immunohistochemistry; D007608:Kainic Acid; D008297:Male; D009833:Olfactory Pathways / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology
D003346:Corticotropin-Releasing Hormone; D007608:Kainic Acid