title: Surgical repair of coarctation of the aorta in neonates: factors affecting early mortality and re-coarctation.
abstract: Between October 1979 and January 1993, 85 Chinese neonates in Hong Kong underwent surgical repair for coarctation of the aorta. Their mean (s.e.) age and body weight at operation was 15.6(8.5) days and 3.06(0.56) kg, respectively. Simple coarctation was present in 17 babies, while 36 had additional ventricular septal defect and 31 had associated major complex intracardiac lesions. Subclavian flap aortoplasty was performed in 56 babies, resection with end-to-end anastomosis in 18 and aortoplasty with the use of a GORETEX patch in 11. The overall early mortality rate was 16.5%. To identify risk factors for early operative mortality, various clinical variables, surgical options, associated heart lesions and dimensions of the aortic arch at different sites for each patient were reviewed. Univariate analysis identified statistically significant differences between the survivors and non-survivors for the following factors: preoperative body-weight, arterial pH and base excess, serum urea and creatinine levels. Stepwise logistic regression further distinguished serum creatinine levels and the period of operation as two significant risk factors. Contrary to previous reports, the dimensions of the aortic arch and type of surgery did not affect early operative mortality. Among the 71 hospital survivors followed for 38.2(38) months, residual or recurrent coarctation of the aorta was detected in 12(17%). The different surgical operations were not related to the incidence of late complication. The size of the distal transverse arch, however, was different (P=0.05) in those who did and did not develop aortic sequela. Successful balloon angioplasty was subsequently performed in 11 patients. In an era of echocardiography with prenatal diagnosis and therapeutic catheterization, early recognition of the disease with prompt prostaglandin infusion should prevent collapse of the baby, thus avoiding renal impairment and sever metabolic acidosis. Balloon angioplasty would offer a simple effective treatment of patients who developed aortic re-coarctation.
authors: Department of Paediatrics and Surgery, The Grantham Hospital and Queen Mary Hospital, University of Hong Kong, China.
authors: J L
authors: JL
authors: Wu
authors: M P
authors: MP
authors: Leung
authors: J
authors: J
authors: Karlberg
authors: C
authors: C
authors: Chiu
authors: J
authors: J
authors: Lee
authors: C K
authors: CK
authors: Mok
mesh_terms: D001017:Aortic Coarctation / Q000150:complications / Q000401:mortality* / Q000503:physiopathology / Q000601:surgery*; D001835:Body Weight; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality*; D003404:Creatinine / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014508:Urea / Q000097:blood; D014656:Vascular Surgical Procedures / Q000379:methods / Q000401:mortality*
chemical_list: D014508:Urea; D003404:Creatinine