title: Dynamic aspects of colicin N translocation through the Escherichia coli outer membrane.
abstract: Colicin N is a bacteriocin that kills sensitive Escherichia coli cells. After binding to the cell surface-exposed receptor, a short period exists when a significant number of the cell-associated colicin N molecules are sensitive to external enzymes. Two colicin N populations are discriminated by proteases: the susceptible pool bound to OmpF porin on the cell surface and another population corresponding to protease-inaccessible colicin N. During translocation, colicin N reaches the periplasmic space and proteolytic cleavage of the colicin occurs only when the outer membrane barrier is permeabilized.
authors: UPR 9027, IBSM-IFR1, Centre National de la Recherche Scientifique, Marseille, France.
authors: R
authors: R
authors: El Kouhen
authors: J M
authors: JM
authors: Pagès
mesh_terms: D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003087:Colicins / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
chemical_list: D003087:Colicins; D010450:Endopeptidases; D011188:Potassium