1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.
Cantorna
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Department of Biochemistry, University of Wisconsin, Madison 53706, USA.
Hayes
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DeLuca
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D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives / Q000627:therapeutic use*; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009103:Multiple Sclerosis; D009169:Mycobacterium tuberculosis; D004676:Myelin Basic Protein / Q000276:immunology; D013116:Spinal Cord; D013997:Time Factors; D014808:Vitamin D Deficiency / Q000503:physiopathology
D004676:Myelin Basic Protein; D002117:Calcitriol