Effect of Daflon 500 mg, a flavonoid drug, on neurological signs, levels of free radicals and electroretinogram in the gerbil after ischemia-reperfusion injury.
The effect of Daflon 500 mg1, purified, micronized flavonoid fraction (90% diosmin, 10% hesperidin) was studied on stroke index, levels of free radicals and electroretinography in the gerbil after ischemia-reperfusion injury. The drug was administered orally at doses of 200, 100 and 50 mg/kg, for 6 days before left carotid occlusion. Daflon 500 mg significantly reversed the increase of stroke index only at the dose of 100 mg/kg and significantly decreased levels of hydroxyl free radicals at all 3 doses with a maximum effectiveness for the dose of 100 mg/kg. Amplitude and latency of the b wave were disturbed after ischemia-reperfusion insult. Daflon 500 mg, 100 mg/kg for 6 days, significantly reversed these modifications. In conclusion, Daflon 500 mg could interact with hydroxyl free radicals, which have a deleterious effect in ischemic tissues, particularly in the retina.
Delbarre
B
B
Faculté de Médecine, Laboratoire de Recherches Chirurgicales et Physiopathologiques, Tours, France.
Delbarre
G
G
Calinon
F
F
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy*; D004145:Diosmin / Q000494:pharmacology*; D004338:Drug Combinations; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005609:Free Radicals / Q000032:analysis; D005849:Gerbillinae; D006569:Hesperidin / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D015427:Reperfusion Injury / Q000188:drug therapy*; D012160:Retina / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology
D004338:Drug Combinations; D005419:Flavonoids; D005609:Free Radicals; C080675:S 5682; D004145:Diosmin; D006569:Hesperidin