Dose-related effects of alcohol on dynamic posturography and oculomotor measures.
Four healthy male volunteers < 30 years of age participated in a blinded study of placebo versus low (0.45 g/kg lean body weight = LBW), medium (0.80 g/kg LBW) and high (1.05 g/kg LBW) dose ethanol ingestion to investigate its effect upon gaze and posture control. Serial electronystagmography and computerized platform posturography were performed at different points along each subject's blood alcohol concentration (BAC) curve as measured by breath analysis. Smooth pursuit and positional testing revealed subtle abnormalities at sub-intoxicating BACs. In addition, instability on posturography was evident on the Sensory Organization Test with no statistically significant influence observed on muscle latency testing as determined by sway analysis. We conclude that even low ethanol BAC levels produce widespread gaze and posture control effects which can be easily documented.
Goebel
J A
JA
Department of Otolaryngology, Washington School of Medicine, St. Louis, MO, USA.
Dunham
D N
DN
Rohrbaugh
J W
JW
Fischel
D
D
Stewart
P A
PA
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects / Q000503:physiopathology*; D000435:Alcoholic Intoxication / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D004856:Postural Balance / Q000187:drug effects* / Q000502:physiology; D011187:Posture / Q000502:physiology*; D014724:Vestibular Function Tests
D000431:Ethanol