[A transplantable model of human laryngeal squamous carcinoma in nude mice].
We have successfully established a human laryngeal squamous carcinoma model in nude mice by transplantation of surgical specimen from patients with laryngeal carcinoma. Histopathological study revealed squamous carcinoma. We named it HLC14. Light and electron microscopy showed that the morphology was similar to that of the original tumor. The transplanted tumor has maintained for more than two years through 25 passages. The tumor grew steadily and fast. The successful rate of transplantation was 100%. Pingyangmycine was then used to treat the transplantable model. The result was satisfactory.
Ye
J
J
Second Affiliated Hospital, Harbin Medical University.
Li
X
X
Shi
L
L
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001761:Bleomycin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C021771:zhengguangmycin