[Follow-up of antidepressive therapy in psychiatric clinical practice].
The therapeutic drug monitoring of antidepressant drugs is of interest to adapt dosage regimens to reduce the number of non-responder patients, to reduce drug side effects and to detect non-compliant patients. A therapeutic range is defined for many of these drugs and their linear or non-linear kinetics are important parameters in clinical practice to define the posology. Some patients, because of when there is drug biotransformation polymorphism, are exposed to drug accumulation a deficit in isoenzymes of cytochrome P450. The existence of these isoenzymes explains the possibility of non-linear kinetics and drug interactions.
Vandel
B
B
Service de Pharmacologie Clinique, Centre Hospitalier Régional Universitaire, Poitiers, France.
Perault
M C
MC
D000928:Antidepressive Agents / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy / Q000523:psychology*; D004347:Drug Interactions; D016903:Drug Monitoring; D005500:Follow-Up Studies; D006801:Humans; D010597:Pharmacogenetics
D000928:Antidepressive Agents
Le suivi thérapeutique des antidépresseurs en pratique clinique psychiatrique.