title: Design of conformationally rigid dimeric MRI agents.
abstract: The conformational flexibility of the linkage mechanism or tether between paramagnetic metal centers is explored to assess optimal structural characteristics of multimeric MRI contrast agents. Two dimeric paramagnetic chelates differing in linkage flexibility but similar in symmetry are compared Relaxivity, water hydration number, and reorientational times of the chelate groups are obtained, and the results demonstrate that greater linkage flexibility reduces overall relaxivity.
authors: Bracco Research USA, Princeton, New Jersey 08540, USA.
authors: R
authors: R
authors: Shukla
authors: M
authors: M
authors: Fernandez
authors: R K
authors: RK
authors: Pillai
authors: R
authors: R
authors: Ranganathan
authors: P C
authors: PC
authors: Ratsep
authors: X
authors: X
authors: Zhang
authors: M F
authors: MF
authors: Tweedle
mesh_terms: D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008968:Molecular Conformation
chemical_list: D002614:Chelating Agents; D003287:Contrast Media