Antiepileptic effects of acidic fibroblast growth factor examined in kainic acid-mediated seizures in the rat.
The possibility that exogenous recombinant human acidic fibroblast growth factor (rhaFGF) may have anticonvulsant properties was investigated in a model of temporal lobe epilepsy in awake rats. We found that after intraperitoneal injection of rhaFGF in kainic acid-treated rats, tonic-clonic convulsions and mortality were decreased by 74% and 77%, respectively. These results are consistent with previous studies showing a neuroprotective effect of FGF against insults to the brain and support a possible therapeutic role for FGF in the treatment of excitotoxic processes.
Cuevas
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Servicio de Histología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Giménez-Gallego
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D000704:Analysis of Variance; D000818:Animals; D004827:Epilepsy / Q000145:classification; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000145:classification / Q000188:drug therapy*
D005346:Fibroblast Growth Factors; D007608:Kainic Acid