title: Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation.
abstract: Reproductive toxicity studies are increasingly including assessments of sperm parameters including motility, morphology, and counts. While these assessments can provide valuable information for the determination of potential reproductive toxicity, the methods for conducting the assessments have not been well developed in all laboratories and are continually evolving. The use of different methods in different laboratories makes comparison of data among laboratories difficult. To address the differences in methods, a working group was convened to discuss methods currently in use, share data, and try to reach consensus about optimal methods for assessing sperm parameters in rats, rabbits, and dogs. This article presents the consensus report, as well as future research needs, with the hope that optimized common methods will aid in the detection of reproductive effects and enhance interlaboratory comparisons.
authors: ILSI Risk Science Institute, Washington, DC 20036, USA.
authors: J
authors: J
authors: Seed
authors: R E
authors: RE
authors: Chapin
authors: E D
authors: ED
authors: Clegg
authors: L A
authors: LA
authors: Dostal
authors: R H
authors: RH
authors: Foote
authors: M E
authors: ME
authors: Hurtt
authors: G R
authors: GR
authors: Klinefelter
authors: S L
authors: SL
authors: Makris
authors: S D
authors: SD
authors: Perreault
authors: S
authors: S
authors: Schrader
authors: D
authors: D
authors: Seyler
authors: R
authors: R
authors: Sprando
authors: K A
authors: KA
authors: Treinen
authors: D N
authors: DN
authors: Veeramachaneni
authors: L D
authors: LD
authors: Wise
mesh_terms: D000818:Animals; D003625:Data Collection / Q000379:methods*; D004285:Dogs; D006077:Government Agencies; D008297:Male; D011817:Rabbits; D051381:Rats; D012958:Societies, Scientific; D013045:Species Specificity; D013076:Sperm Count / Q000379:methods*; D013081:Sperm Motility / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology*; D014481:United States