title: Histologic effects of collagen-filled interlocking detachable coils in the ablation of experimental aneurysms in swine.
abstract: OBJECTIVE
  To assess the histologic changes produced by platinum microcoils with an inner core of cross-linked bovine collagen in experimentally induced aneurysms in swine, and to assess the feasibility of the system for the delivery of the collagen.
  
  
  METHODS
  Bilateral pouch aneurysms were created in the side wall of the common carotid artery in seven barnyard pigs. Eight aneurysms were treated with coils designed with an interlocking detachment mechanism: in four of these, the coils had an inner core of collagen; in the other four, the platinum microcoils had a similar design but without the collagen mandrel. The packing density of the coils within the aneurysm was approximately the same for both types of coils. The other six aneurysms were left untreated and served as controls. Angiograms were obtained at the time of treatment (2 weeks after the aneurysms were created) and at 1, 4, and 8 weeks after treatment. All animals were killed 8 weeks after the treatment (10 weeks after the aneurysms were created). Arteries and aneurysms were resected en bloc and fixed for histopathologic study.
  
  
  RESULTS
  The interlocking detachment mechanism worked well. Little difference was noted between the two types of coils in their ability to effect complete aneurysmal thrombosis (three of four aneurysms treated with collagen-core coils and two of four aneurysms treated with conventional coils). The collagen-core coils stimulated new collagen formation in areas proximal to the coils, and more fibroblasts were noted near the collagen-core coils than near the conventional coils.
  
  
  CONCLUSIONS
  Local fibroblast proliferation and collagen production were stimulated by heterologous cross-linked collagen embedded in micro-coils in this experimental model. Such biologic stimulation holds promise for improving the endovascular cure rate of aneurysms in humans.
authors: Department of Radiology, Emory University, Atlanta, Ga, USA.
authors: R C
authors: RC
authors: Dawson
authors: G G
authors: GG
authors: Shengelaia
authors: A F
authors: AF
authors: Krisht
authors: G D
authors: GD
authors: Bonner
mesh_terms: D000783:Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D000792:Angiography; D000818:Animals; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D002417:Cattle; D002455:Cell Division; D003094:Collagen / Q000096:biosynthesis / Q000627:therapeutic use*; D003432:Cross-Linking Reagents; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D005240:Feasibility Studies; D005347:Fibroblasts / Q000473:pathology; D005500:Follow-Up Studies; D010984:Platinum; D013552:Swine
chemical_list: D003432:Cross-Linking Reagents; D010984:Platinum; D003094:Collagen