title: [Non-invasive intermittent mechanical ventilation: usefulness in treatment of chronic severe heart failure].
abstract: BACKGROUND
  The higher respiratory work and less inspiratory muscle strength of patients with cardiac failure may contribute to decrease their functional capacity.
  
  
  OBJECTIVE
  To assess the effects of non invasive intermittent mechanical ventilation on clinical parameters, peripheral perfusion, cardiac and inspiratory muscle function.
  
  
  METHODS
  Patients with chronic cardiac failure, functional capacity III-IV were subjected to 6 sessions of nasal non invasive intermittent ventilation during 4 hours or to simulated ventilation (controls).
  
  
  RESULTS
  Fifteen ventilated patients and six controls completed the protocol. Ventilated patients improved the Mahler transition score for dyspnea by 4 +/- 1.6 points. They also improved their aerobic capacity, increasing the exercise duration from 10.9 +/- 4 to 12.7 +/- 5 min and their maximal oxygen consumption from 14.6 +/- 4 to 16.4 +/- 5.7 ml/kg/min. These patients also decreased their O2 and CO2 ventilatory equivalents. Maximal inspiratory pressure increased from 67.9 +/- 23.6 to 80.19 +/- 21.4 cm H2O, sustained maximal inspiratory pressure increased from 101.4 +/- 48 to 133 +/- 53 cm H2O and maximal endurance increased from 132 +/- 52 to 162 +/- 58 g in ventilated patients. None of these variables was modified in control patients. No changes were observed in renal function, blood volume, arterial gases, spirometry or plasma catecholamine levels in any group.
  
  
  CONCLUSIONS
  Intermittent nasal ventilation or other measures to improve inspiratory muscle function may be beneficial for patients with severe cardiac failure.
authors: Departamento de Enfermedades Cardiovasculares, Universidad Católica de Chile, Santiago.
authors: A
authors: A
authors: Martínez
authors: V
authors: V
authors: Muñoz
authors: C
authors: C
authors: Lisboa
authors: J
authors: J
authors: Jalil
authors: I
authors: I
authors: Godoy
authors: R
authors: R
authors: Moreno
authors: R
authors: R
authors: Ferretti
authors: P
authors: P
authors: Casanegra
authors: F
authors: F
authors: Saldías
authors: E
authors: E
authors: Guarda
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002908:Chronic Disease; D002985:Clinical Protocols; D005260:Female; D006333:Heart Failure / Q000628:therapy*; D006339:Heart Rate; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008451:Maximal Voluntary Ventilation; D008875:Middle Aged; D011897:Random Allocation; D012132:Respiratory Muscles / Q000502:physiology
vernacular_title: Ventilación mecánica no invasiva intermitente: utilidad en el tratamiento de la insuficiencia cardíaca crónica avanzada.