[The effect of cytokines on the liver necrosis].
OBJECTIVE
To investigate the effect of cytokines on liver necrosis.


METHODS
We injected IL-1, IL-6, IFN gamma, TNF alpha with or without D-galactosamine (D-GAL) into the abdominal cavity of mice separately.


RESULTS
There was no effect on hepatocyte of normal mice after injection of IL-1, IL-6, IFN gamma alone or together. The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.


CONCLUSIONS
Cytokines like IL-1, IL-6, IFN gamma and TNF alpha joined the process of hepatocyte necrosis. They can enhance the degree of liver necrosis induced by D-GAL.
Yu
Y
Y
Department of Infections Diseases, First Hospital, Beijing Medical University.
Si
C
C
Tian
X
X
D000818:Animals; D001663:Bilirubin / Q000097:blood; D005688:Galactosamine / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology; D008099:Liver / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D007375:Interleukin-1; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D005688:Galactosamine; D007371:Interferon-gamma; D001663:Bilirubin