[Cancer chemotherapy and apoptosis].
Tumor cells undergo apoptotic cell death when treated with several chemotherapeutic agents. Since these agents, acting on different cellular targets, induce a similar pattern of cell death (apoptosis), it is suggested that a common signaling pathway of apoptosis could exist and that apoptosis resistance could cause a new form of multi-drug resistance in tumor cells. Although the mechanisms of apoptosis are not fully understood, the involvement of ICE/ced-3 family proteases in chemotherapy-induced apoptosis is strongly suggested. Identification of factors directly acting on these apoptosis pathway will offer new strategies in cancer chemotherapy.
Mashima
T
T
Institute of Molecular and Cellular Biosciences, University of Tokyo.
Naito
M
M
Kataoka
S
S
Tsuruo
T
T
D000199:Actins; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D002453:Cell Cycle; D018432:Drug Resistance, Multiple; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015843:Serpins; D014764:Viral Proteins
D000199:Actins; D000970:Antineoplastic Agents; D015843:Serpins; D014764:Viral Proteins; C074641:interleukin-1beta-converting enzyme inhibitor