Experimental tolerance to perfluorodecalin used in prolonged intraocular tamponade.
The authors report the results of an experimental study of a series of 16 rabbit eyes that underwent prolonged tamponade by a liquid perfluorocarbon (LPFC). After vitreous compression by C3F8, a complete gas/LPFC exchange is performed and left in place for 48 h, 12 days and 21 days. Study of the retina by light and electron microscopy showed numerous lesions: vacuolization in the nerve fiber layer, progressive defects of the outer photoreceptor segments and presence of pseudomyelinic bodies in the inner plexiform layer. The axonal fiber loss is shown by a specific marker. The analysis of the results underlines the mechanical toxicity of LPFCs used in prolonged tamponade, which are too heavy for the neurosensory retina.
Devin
F
F
Department of Ophthalmology, CHU Timone, France.
Jourdan
T
T
Saracco
J B
JB
Lucciani
A
A
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000473:pathology; D005466:Fluorocarbons / Q000633:toxicity*; D009412:Nerve Fibers / Q000187:drug effects / Q000473:pathology; D010786:Photoreceptor Cells / Q000187:drug effects / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D014617:Vacuoles / Q000187:drug effects / Q000473:pathology; D014822:Vitreous Body
D005466:Fluorocarbons; C008805:perfluorodecalin