Calcium dependent intercellular interaction of the neural crest derivate-melanocytes and the epithelial cells of the vestibular organ.
As recently established in several species, the presence of neural crest derivate-melanocytes is essential for the development of the epithelial cells regulating the ion and the potential gradients in the inner ear. The interaction between the melanocytes and the epithelial cells appears to be activated when intracellular Ca2+ increases. This may be due to a disturbance of the Ca2+ homeostasis under hydropic conditions or to the effect of the Ca-ionophore (A 23187) or hormone (alpha-MSH). Lowering of extracellular Ca2+ blocked the effect of the drug at the basal level. The interaction of the melanocytes with the epithelial or endothelial cells differs significantly. It is indicated that melanocytes may be under hormonal control and that their activation and intercellular interaction are related to the increase of intracellular Ca2+ and may be controlled by extracellular Ca2+. Furthermore, we propose that melanocytes provide a regulatory network for the maintenance of the inner ear homeostasis.
Meyer zum Gottesberge
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Department of Otorhinolaryngology, Heinrich-Heine-University of Düsseldorf, Germany.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D003712:Dendrites / Q000473:pathology; D004195:Disease Models, Animal; D018159:Endolymphatic Hydrops / Q000473:pathology*; D004727:Endothelium / Q000473:pathology; D006706:Homeostasis / Q000502:physiology; D008544:Melanocytes / Q000473:pathology*; D009432:Neural Crest / Q000473:pathology*; D014722:Vestibule, Labyrinth / Q000473:pathology*; D000521:alpha-MSH / Q000502:physiology
D000521:alpha-MSH; D002118:Calcium