The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia.
Latent inhibition (LI) consists in a retardation of conditioning seen when the to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.
Gray
J A
JA
Department of Psychology and MRC Behavioural Neurochemistry Group, Institute of Psychiatry, Denmark Hill, London, UK.
Joseph
M H
MH
Hemsley
D R
DR
Young
A M
AM
Warburton
E C
EC
Boulenguez
P
P
Grigoryan
G A
GA
Peters
S L
SL
Rawlins
J N
JN
Taib
C T
CT
D000818:Animals; D001519:Behavior / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008032:Limbic System / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology; D009475:Neurons, Afferent / Q000502:physiology*; D009714:Nucleus Accumbens / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D013216:Reflex, Startle / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*
D004298:Dopamine