Rosai-Dorfman disease presenting with multiple orbital and intracranial masses.
Rosai-Dorfman disease is an idiopathic histocytic proliferative disorder typically characterized by painless cervical adenopathy, fever, and weight loss. Extranodal manifestations are responsible for presentation in approximately 25% of patients. Orbital involvement has been described in about 10% of patients. There have been only 16 reported cases of Rosai-Dorfman disease presenting with an intracranial mass. We report an unusual case of a patient presenting with bilateral orbital tumors as well as multiple intracranial masses. Clinical, magnetic resonance imaging, and histopathological features are discussed.
Resnick
D K
DK
Department of Neurological Surgery, Presbyterian University Hospital, Pittsburgh, PA 15213-2582, USA.
Johnson
B L
BL
Lovely
T J
TJ
D000328:Adult; D001927:Brain Diseases / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000473:pathology; D002530:Cerebellopontine Angle; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D008297:Male; D009916:Orbital Diseases / Q000473:pathology*