[Liver cirrhosis and granulomatous hepatitis after prolonged ingestion of lysine acetylsalicylate].
We report the case of a 75-year-old woman who was hospitalized for serum aminotransferase elevation. She had taken 1 g/d of salicylate therapy (Aspegic 1000) for 5 years, clorazepate for 10 years, naftidrofuryl for 8 months and quinapril for 3 months. Liver histology showed cirrhosis and granulomatous hepatitis. Discontinuation of salicylate therapy resulted in normalization of liver tests, although other drug administration was pursued. This observation suggests that salicylate therapy can induce cirrhosis.
D'Abrigeon
G
G
Service d'Hépato-Gastroentérologie, Institut des Maladies de l'Appareil Digestif, Montpellier.
Blanc
P
P
Durand
L
L
Larrey
D
D
Michel
H
H
D000368:Aged; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008239:Lysine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012216:Rheumatic Diseases / Q000188:drug therapy; D013997:Time Factors
D000700:Analgesics; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Cirrhose et hépatite granulomateuse après la prise prolongée d'acétylsalicylate de lysine.