title: A cross sectional study of chemical industry workers with occupational exposure to persulphates.
abstract: OBJECTIVE
  Hair bleaches containing persulphates have been identified as the cause of occupational asthma in hairdressers. Also employees in persulphate production with occupational asthma have been described. It was the aim of this study to give an estimate of the prevalence of asthma due to persulphates in chemical workers with exposure to ammonium and sodium persulphate.
  
  
  METHODS
  A cross sectional study was performed in 32 of 33 employees of a persulphate producing chemical plant. Eighteen of 23 workmen from the same plant with no exposure to persulphates were taken as controls. Also, information was collected from medical records of the seven subjects who had left the persulphate production for medical reasons since 1971. Data were recalled by a questionnaire, skin prick tests were performed with five environmental allergens, and ammonium and sodium persulphate (80 mg/ml). Specific immunoglobulin E (IgE) to the same environmental allergens as in the skin test, and total IgE were measured. Lung function and bronchial responsiveness to histamine were assessed by standard procedures. Workplace concentrations of ammonium and sodium persulphate were estimated by area and personal monitoring. The amount of persulphate was analysed as sulphur by inductively coupled plasma emission spectrometry.
  
  
  RESULTS
  Work related rhinitis was reported by one subject with exposure to persulphates, conjunctivitis and bronchitis were reportedly related to work by two controls. There were no cutaneous reactions to persulphates in either group. Four non-atopic subjects exposed to persulphates, and two controls, one atopic and one non-atopic, were considered to be hyperresponsive to histamine. Three subjects exposed to persulphates with bronchial hyperresponsiveness (provocation dose of histamine causing a 15% fall in forced expiratory volume in one second (PD15 FEV1) < or = 1 mg) did not show variability in peak expiratory flow of > or = 20%, the rest refused peak flow measurements. None of the variables showed significant differences between the groups (P > 0.05). Six of the exworkers left because of work related contact dermatitis. Mean values for workplace concentrations of ammonium and sodium persulphate within the bagging plant were below 1 mg/m3, and the maximal concentrations were 1.4 mg/m3 and 3.6 mg/m3, respectively.
  
  
  CONCLUSIONS
  Exposure to workplace concentrations of ammonium and sodium persulphate of about 1 mg/m3 in this chemical plant was not associated with a risk of occupational asthma.
authors: Department of Internal Medicine, University Hospital, Bergmannsheil, Germany.
authors: R
authors: R
authors: Merget
authors: A
authors: A
authors: Buenemann
authors: R
authors: R
authors: Kulzer
authors: A
authors: A
authors: Rueckmann
authors: R
authors: R
authors: Breitstadt
authors: A
authors: A
authors: Kniffka
authors: H
authors: H
authors: Kratisch
authors: R
authors: R
authors: Vormberg
authors: G
authors: G
authors: Schultze-Werninghaus
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology; D000645:Ammonium Sulfate / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D016535:Bronchial Hyperreactivity / Q000139:chemically induced; D002617:Chemical Industry; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008448:Maximal Expiratory Flow Rate / Q000187:drug effects; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects; D010545:Peroxides / Q000009:adverse effects*; D012882:Skin Tests; D013464:Sulfuric Acids / Q000009:adverse effects*
chemical_list: D000485:Allergens; D010545:Peroxides; D013464:Sulfuric Acids; C031276:ammonium peroxydisulfate; C071517:monoperoxysulfate; D000645:Ammonium Sulfate