title: Clinical and serological observations on experimental infections with Babesia canis and its diagnosis using the IFAT.
abstract: Naive Beagle dogs (n = 5) were experimentally inoculated with two stocks of Babesia canis. Dogs were examined regularly for parasitaemia and for antibodies, using the indirect immunofluorescent antibody test (IFAT). This test proved to be useful for the diagnosis of babesiosis. After primo-infection dogs seem to develop a certain degree of immunity, although this immunity is neither absolute nor of long duration. Treatment of infected dogs with imidocarb (6 mg/kg) cleared the infection, but did not prevent the production of IFAT-antibodies. An infected dog treated with long acting oxytetracycline (20 mg/kg) became a subclinical, chronic carrier of the disease.
authors: Veterinary Department, Institute of Tropical Medicine, Antwerpen.
authors: F
authors: F
authors: Vercammen
authors: R
authors: R
authors: De Deken
authors: L
authors: L
authors: Maes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000032:analysis; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001404:Babesiosis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D002353:Carrier State; D004285:Dogs; D019084:Fluorescent Antibody Technique, Indirect; D007095:Imidocarb / Q000627:therapeutic use; D010118:Oxytetracycline / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000913:Antibodies, Protozoan; D000981:Antiprotozoal Agents; D007095:Imidocarb; D010118:Oxytetracycline