Ribozymes: structure and mechanism in RNA catalysis.
The hammerhead RNA is a small catalytic RNA found in a number of RNA virus genomes and virus-like RNAs. The recently determined crystal structures of hammerhead ribozymes reveal how a small RNA motif can fold up into a conformation suitable for mediating RNA cleavage.
Scott
W G
WG
MRC Laboratory of Molecular Biology, Cambridge, UK.
Klug
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D001483:Base Sequence; D018360:Crystallography, X-Ray; D008274:Magnesium / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000494:pharmacology; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism
D008670:Metals; D016337:RNA, Catalytic; D012367:RNA, Viral; D012313:RNA; D008274:Magnesium