Fos is not involved in the regulation of the proenkephalin gene by haloperidol in the mouse striatum.
The aim of the study was to determine whether the haloperidol-produced induction of the c-fos gene in the mouse striatum is the cause of the increased expression of the striatal proenkephalin (PENK) gene after repeated haloperidol administration. Mice were treated with haloperidol (1 mg/kg, i.p., once daily), MK-801 (1 mg/kg, i.p., twice daily), or with both those drugs for 9 days. Pretreatment with MK-801 prevented the haloperidol-produced induction of the striatal c-fos mRNA. In animals injected with haloperidol for 9 days, levels of the striatal PENK mRNA were increased by 100%. Coadministration of MK-801 did not reduce that increase. These results suggest that Fos is not necessary for activation of the PENK gene expression, produced by chronic haloperidol application, in the striatum.
Ziółkowska
B
B
Physiologisches Institut, Universität Müchen, Germany.
Höllt
V
V
D000704:Analysis of Variance; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004745:Enkephalins / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects*; D016762:Genes, fos; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011498:Protein Precursors / Q000235:genetics*
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004745:Enkephalins; D011498:Protein Precursors; C029992:proenkephalin; D016291:Dizocilpine Maleate; D006220:Haloperidol