title: [Intraoperative radiation therapy: its technological support, potentials and prospects].
abstract: The authors' experience with intraoperative radiotherapy (IORT) in 129 patients with a tumorous process at various sites has demonstrated that in most clinical events, single radiation doses of 10-20 Gy is insufficient to have a persistent local effect and requires additional pre- or postoperative remote irradiation. The use of IORT as a single component of radiation exposure does not lead to significant radiation damages to normal tissues. When IORT is combined with remote irradiation (the latter using doses of 30-60 Gy), 30% of patients develop radiation-induced normal tissue lesions. In the context of enhancing the local effect and, if possible, decreasing the dose of remote irradiation, it is expedient to increase IORT doses, which is in turn fraught with higher incidence and severity of radiation lesions. In this connection, it seems urgent to have a look for the potentialities to expand the radiotherapeutical range. This follows several directions.
authors: A V
authors: AV
authors: Boĭko
authors: A V
authors: AV
authors: Chernichenko
authors: V I
authors: VI
authors: Chissov
authors: V A
authors: VA
authors: Kvasov
authors: E S
authors: ES
authors: Kiseleva
authors: S L
authors: SL
authors: Dar'ialova
authors: L V
authors: LV
authors: Demidova
authors: Iu A
authors: IuA
authors: Rakhmanin
authors: N A
authors: NA
authors: Osipova
authors: Iu S
authors: IuS
authors: Donskova
authors: I G
authors: IG
authors: Rusakov
authors: E G
authors: EG
authors: Novikova
authors: A S
authors: AS
authors: Mamontov
authors: L A
authors: LA
authors: Vashakhmadze
authors: I V
authors: IV
authors: Reshetov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D004583:Electrons / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009369:Neoplasms / Q000532:radiotherapy / Q000601:surgery; D010315:Particle Accelerators; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000295:instrumentation / Q000379:methods* / Q000639:trends
vernacular_title: Intraoperatsionnaia luchevaia terapiia: tekhnologicheskoe obespechenie, vozmozhnosti, perspektivy.