title: Prognostic value of abnormal EEG transients in preterm and full-term neonates.
abstract: The prognostic value of abnormal EEG transients was investigated in 362 subjects submitted to EEG recording during the neonatal age and followed-up at least until the 12th month of corrected age. The incidence of negative and positive spikes and sharp waves, of rhythmic sharp theta and delta activities and of alpha discharges were evaluated by means of a quantitative score. These abnormal EEG transients appeared to be generally rare and even absent in a large number of subjects. In infants with normal outcome their incidence tends to increase from low postmenstrual ages towards term period. Full-term newborns with abnormal neurological outcome presented a significantly higher incidence of these transients. Preterm infants with unfavourable evolution showed a higher incidence only when submitted to EEG recording at around term age. However, no difference between subjects with normal and abnormal outcome was detected in preterm infants when evaluated at low postmenstrual ages. The hypothesis that at low postmenstrual ages brain damage might, on the one hand, give rise to abnormal transients and, on the other, alter the "capability' of manifesting them (together with other EEG maturational aspects), might explain these results.
authors: Stella Maris Scientific Institute, University of Pisa, Calambrone, Italy. ebiagioni@inpe.unipi.it
authors: E
authors: E
authors: Biagioni
authors: A
authors: A
authors: Boldrini
authors: U
authors: U
authors: Bottone
authors: R
authors: R
authors: Pieri
authors: G
authors: G
authors: Cioni
mesh_terms: D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D011379:Prognosis