Enhanced effect of clarithromycin on neutrophil function in vitro.
An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 micrograms/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.
Akamatsu
H
H
Department of Dermatology, Kansai Medical University, Osaka, Japan.
Niwa
Y
Y
Sasaki
H
H
Asada
Y
Y
Horio
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D017291:Clarithromycin / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D017665:Hydroxyl Radical / Q000097:blood; D066298:In Vitro Techniques; D007700:Kinetics; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000097:blood
D000900:Anti-Bacterial Agents; D017382:Reactive Oxygen Species; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D017291:Clarithromycin