[An experimental study on the treatment of fetal rabbits with intrauterine growth retardation].
OBJECTIVE
To investigate the effect of histocyte activators and vasodilators on the amino acids concentration in fetal rabbits with intrauterine growth retardation (IUGR).


METHODS
The rabbits with IUGR were caused by passive smoking and treated with histocyte activators (adenosine triphosphatase, coenzyme A, cytochrome C, and vasodilators (injectio salviac molfiorrhizae composita, anisodamine). The effects of different remedies on the fetal plasma amino acids' concentration and the fetal development (i.e. birth weight, the weights of fetal liver and fetal brain) were studied.


RESULTS
Both histocyte activators and vasodilators had favorable effects on the improvement of fetal development and the increase of fetal plasma amino acids' concentration. But the action of histocyte activators was stronger than vasodilators.


CONCLUSIONS
The results suggested that vasodilators could improve the uterine-placental flow, and histocyte activators could enhance placental transfer of amino acids. But histocyte activators seem to be better than vasodilators.
Zhang
X
X
Third Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
Yan
J
J
Hong
S
S
D000255:Adenosine Triphosphate / Q000627:therapeutic use; D000596:Amino Acids / Q000097:blood; D000818:Animals; D003065:Coenzyme A / Q000627:therapeutic use; D003574:Cytochrome c Group / Q000627:therapeutic use; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000188:drug therapy*; D011247:Pregnancy; D011817:Rabbits; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000596:Amino Acids; D003574:Cytochrome c Group; D012991:Solanaceous Alkaloids; D014028:Tobacco Smoke Pollution; D014665:Vasodilator Agents; C003922:anisodamine; D000255:Adenosine Triphosphate; D003065:Coenzyme A