Genetic immunization.
Genetic immunization, the latest addition to the field of vaccinology, has shown, in a number of animal models, to be an efficacious approach to induce protective immunity to infectious diseases. The advantages of DNA vaccines are their ease of construction, the low expanse of mass production, their high temperature stability, and their ability to induce a full spectrum of exceptionally long-lasting immune responses including cytolytic T cells. Their potential disadvantages are putative safety issues such as integration into the host cell genome. The slow development of the immune response to genetic immunization will make these vaccines unsuitable for treatment of some infectious disease such as postexposure vaccination to rabies virus, where a rapid immune response is warranted. Although only time will tell if genetic immunization provides a viable alternative for human immunization, in the meantime this approach provides immunologists with a powerful tool to gain further insight in the mechanisms that drive primary immune responses.
Ertl
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HC
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA.
Xiang
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ZQ
D000818:Animals; D004247:DNA / Q000276:immunology*; D005822:Genetic Vectors; D006801:Humans; D007114:Immunization / Q000379:methods*; D018448:Models, Immunological; D010957:Plasmids
D004247:DNA