Hypertensive effect of tissue kallikrein in rostral ventrolateral medulla is mediated by brain kinins.
Microinjections of kallikrein, 0.5-2.0 units, in the rostral ventrolateral medulla (RVLM) of brain increased arterial pressure in Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). This effect was significantly greater in SHR. The kinin B2 receptor antagonist icatibant (Hoe 140) blocked the hypertensive responses to kallikrein in both groups and caused greater hypotension and bradycardia in SHR. These results suggest that local kinins in the RVLM act to alter cardiovascular function and may be involved in the maintenance of blood pressure in the SHR.
Privitera
P J
PJ
Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston 29425, USA.
Yates
P
P
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology; D065168:Bradykinin Receptor Antagonists; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced*; D007610:Kallikreins / Q000494:pharmacology*; D007705:Kinins / Q000502:physiology*; D008526:Medulla Oblongata / Q000187:drug effects*; D008845:Microinjections; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D043782:Receptor, Bradykinin B2
D065168:Bradykinin Receptor Antagonists; D007705:Kinins; D043782:Receptor, Bradykinin B2; C065679:icatibant; D007610:Kallikreins; D001920:Bradykinin