Purely cutaneous Rosai--Dorfman disease.
Cutaneous lesions of Rosai-Dorfman disease (RDD) are usually associated with nodal or other extranodal localization. We describe a female patient with RDD clinically limited to the skin. The patient presented with asymptomatic red-brown papules and nodules on the legs, arms, back, and nose. Histologically, the lesions consisted of a proliferation of large histiocytes occasionally showing emperipolesis. Histiocytes were also observed within dilated lymphatic vessels. Immunohistochemical study showed that histiocytes expressed S-100 protein and both macrophage and monocyte markers. All lesions resolved completely with Roentgen therapy. No recurrence has been observed over a 3-year follow-up period.
Annessi
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Clinica Dermatologica Università di Modena, Istituto Dermopatico dell'Immacolata IRCCS, Roma, Italy.
Giannetti
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A
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D012871:Skin Diseases / Q000473:pathology* / Q000532:radiotherapy