Dietary modifiers of carcinogenesis.
Dietary components express a wide range of activities that can affect carcinogenesis. Naturally occurring substances in foods have been shown in laboratory experiments to serve as dietary antimutagens, either as bioantimutagens or as desmutagens. Dietary desmutagens may function as chemical inactivaters, enzymatic inducers, scavengers, or antioxidants. Dietary components may also act later in the carcinogenic process as tumor growth suppressors. Examples of dietary factors acting in each of these stages of carcinogenesis are presented, and potential anticarcinogens such as the carotenoids, tocopherols, phenolic compounds, glucosinolates, metal-binding proteins, phytoestrogens, and conjugated linoleic acid are discussed. Individual foods typically contain multiple potential anticarcinogens. Many of these substances can influence carcinogenesis through more than one mechanism. Some substances exhibit both anticarcinogenic and carcinogenic activity in vitro, depending on conditions. Epidemiologic research indicates that high fruit and vegetable consumption is associated with lower cancer risk. Little research has focused on the effects of single substances or single foods in man. Realization of the potential of foodborne substances to reduce the human burden of cancer will only be achieved with better measurement of dietary exposures and funding of multidisciplinary research in this area commensurate with its importance.
Kohlmeier
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Departments of Nutrition and Epidemiology, Schools of Public Health and Medicine, Chapel Hill, North Carolina, USA.
Simonsen
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N
Mottus
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D005502:Food; D016166:Free Radical Scavengers / Q000494:pharmacology; D005961:Glucosinolates; D006801:Humans; D009153:Mutagens / Q000494:pharmacology; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control*; D010636:Phenols; D014815:Vitamins
D016588:Anticarcinogenic Agents; D016166:Free Radical Scavengers; D005961:Glucosinolates; D009153:Mutagens; D010636:Phenols; D014815:Vitamins