Transient false-positive hepatobiliary scan associated with ceftriaxone therapy.
Drug related false-positive hepatobiliary imaging is uncommon. The authors present a case of a 54-year-old woman who was treated with intravenous ceftriaxone for bacterial meningitis. Symptoms of acute cholecystitis subsequently developed and a sonogram revealed a gallstone. A Tc-99m DISIDA hepatobiliary study was positive for cystic duct obstruction. After discontinuation of ceftriaxone, the patient's clinical condition improved and, 2 weeks later, a repeat hepatobiliary scan was normal. High doses of ceftriaxone and prolonged administration may lead to formation of pseudocholelithiasis and signs of acute cholecystitis. Although this condition is usually benign and reversible, discontinuation of the drug is warranted when symptoms of acute cholecystitis are accompanied by a positive hepatobiliary scan.
Lorberboym
M
M
Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Machado
M
M
Glajchen
N
N
Pertsemlidis
D
D
D002443:Ceftriaxone / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D002764:Cholecystitis / Q000000981:diagnostic imaging; D002769:Cholelithiasis / Q000000981:diagnostic imaging; D005189:False Positive Reactions; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000187:drug effects; D006801:Humans; D007098:Imino Acids; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019785:Technetium Tc 99m Disofenin
D002511:Cephalosporins; D007098:Imino Acids; D015609:Organotechnetium Compounds; D002443:Ceftriaxone; D019785:Technetium Tc 99m Disofenin