[The role of the polymorphonuclear neutrophil in the failure of multiple organs and systems].
The role of the polymorphonuclear neutrophil (PMN) on MOF is analyzed either as PMN activation for superoxide and enzyme release, or as PMN function depression after trauma and surgery. The authors stress: 1) the signal transduction pathway from the PMN membrane receptors to the effector response; 2) the PMN-NADPH system structure and function; 3) the functional states of the PMN (quiescente, primed, activated, non-responsive) in terms of the NADPH system activation; 4) the mechanism of tissue injuiry by the PMN. Clinical investigations on the PMN activation state, and therapeutical goals based on recent clinical investigations are also discussed.
Fontes
B
B
Departamento de Cirurgia, Universidade de São Paulo.
Sergio Poggetti
R
R
D000818:Animals; D006801:Humans; D009102:Multiple Organ Failure / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D009247:NADH, NADPH Oxidoreductases
Papel do pmn na falência de múltiplos órgãos e sistemas.