Fractal representation of the immune B cell repertoire.
The immune repertoire is characterized by a complex and dynamic organization. Here I suggest, based on the presence of well-defined immune reactivity patterns (RP) analyzed using a linguistic analogy, that the B cell repertoires could possess a fractal structure. A simple estimation method of the fractal dimension (D) for a given immune B repertoire was developed, and D demonstrated to be an useful tool to define what complexity is regarding the immune repertoire, and to evaluate the complexity level of the immune B repertoire among age-structured groups of mice sensitized with the hemagglutinin (HA) molecule of influenza virus. Also, since a fractal-linguistic point of view, considerations are made about the ontogeny, connectivity, chaotic regimes, and size of the immune repertoire. Fractal analysis indicates that the immune repertoire shows a Zipf-like scaling behavior, a statistical property of natural languages. This result suggests that immune repertoire is structured like a powerful language.
Burgos
J D
JD
Laboratorio Biotecnologico, Universidad INCCA de Colombia, Bogotá, Colombia.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000916:Antibody Diversity; D001402:B-Lymphocytes / Q000276:immunology*; D017709:Fractals; D006389:Hemagglutinins, Viral / Q000276:immunology; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D017711:Nonlinear Dynamics; D009975:Orthomyxoviridae / Q000276:immunology
D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral