title: Kinetochore function: molecular motors, switches and gates.
abstract: Kinetochores are essential for accurate chromosome segregation. Recent studies reveal that vertebrate kinetochores are sophisticated propulsion systems composed of not only force generators but also "navigation' and "fail-safe' mechanisms. Advances toward the understanding of the biochemical composition and activities of the components of the kinetochore have come from the molecular characterization of key proteins of the kinetochore complex.
authors: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. TJ.Yen@fccc.edu
authors: T J
authors: TJ
authors: Yen
authors: B T
authors: BT
authors: Schaar
mesh_terms: D000818:Animals; D016547:Kinesins / Q000502:physiology*; D018386:Kinetochores / Q000737:chemistry* / Q000502:physiology*
chemical_list: D016547:Kinesins