title: Symptoms and well-being in relation to glycemic control in type II diabetes.
abstract: OBJECTIVE
  To describe the cross-sectional relation between glycemic control and physical symptoms, emotional well-being, and general well-being in patients with type II diabetes.
  
  
  METHODS
  The study population consisted of 188 patients with type II diabetes between 40 and 75 years of age. Patients were treated with blood glucose-lowering agents or had either a fasting venous plasma glucose level > or = 7.8 mmol/l or an HbA1c level > 6.1%. Multiple regression analyses were performed. Dependent variables were scores on the Type II Diabetes Symptom Checklist, the Profile of Mood States, the Affect Balance Scale, and questions regarding general well-being. The primary determinant under study was HbA1c. In addition, age, sex, neuroticism (indicating a general tendency to complain), insulin use, and comorbidity were included as determinants in all analyses. Other potential determinants taken into consideration were hypoglycemic complaints, marital status, diabetes duration, cardiovascular history, blood pressure, BMI, waist-to-hip ratio, perceived burden of treatment, and smoking. None of these potential determinants had to be included to correct confounding of the relation between HbA1c and well-being scores.
  
  
  RESULTS
  Higher HbA1c levels were significantly associated with higher symptom scores (total score, hyperglycemic score, and neuropathic score), with worse mood (total score, displeasure score, depression, tension, fatigue), and with worse general well-being. The relative risks varied between 1.02 and 1.36 for each percentage difference in HbA1c. The relation between HbA1c and some mood states was modified by neuroticism: in the less neurotic patient (i.e., one who is less inclined to complain), the relation was more evident.
  
  
  CONCLUSIONS
  These data suggest that better glycemic control in type II diabetes is associated with fewer physical symptoms, better mood, and better well-being, in a nonhypoglycemic HbA1c range.
authors: Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, Netherlands.
authors: F E
authors: FE
authors: Van der Does
authors: J N
authors: JN
authors: De Neeling
authors: F J
authors: FJ
authors: Snoek
authors: P J
authors: PJ
authors: Kostense
authors: P A
authors: PA
authors: Grootenhuis
authors: L M
authors: LM
authors: Bouter
authors: R J
authors: RJ
authors: Heine
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D001294:Attitude to Health; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003863:Depression; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology* / Q000523:psychology*; D005221:Fatigue; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006304:Health Status; D006801:Humans; D006943:Hyperglycemia / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders; D012044:Regression Analysis; D012737:Sex Factors; D013315:Stress, Psychological
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin