[Thyroid nodule in Basedow-Graves disease and thyroid cancer: experience in 6 patients].
Traditionally, Basedow-Graves disease was considered a protection against thyroid cancer. However, recent reports suggest that cancer occurs with a higher frequency than expected and is more aggressive in this disease. We report six patients with hyperthyroidism due to a Basedow Graves disease that presented a palpable thyroid nodule, which was cold in the scintiscan and solid in the ultrasound examination. Fine needle cytology disclosed cancer in five cases (two with cytological features of greater aggressiveness) and a nodular hyperplasia in one. The diagnosis was confirmed in the surgical piece in all patients. We conclude that Basedow-Graves disease and thyroid cancer, which can have an increased aggressiveness, may coexist.
Piraino
P
P
Servicio de Anatomía Patológica y Servicio de Cirugía, Universidad de Chile, Santiago.
Sepúlveda
A
A
Ibarra
A
A
Michelsen
H
H
Gac
A
A
Pumarino
H
H
D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D011441:Propylthiouracil / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D014463:Ultrasonography
D011441:Propylthiouracil; D011433:Propranolol
Nódulo tiroideo en enfermedad de Basedow Graves y cáncer tiroideo: experiencia en 6 pacientes.