title: [Immunological indicators in patients with pulmonary tuberculosis in the presence of drug-resistant Mycobacteria].
abstract: Immunological indices for 121 pulmonary tuberculosis (PT) patients discharging drug-resistant M. tuberculosis were compared to those for 87 PT patients with M. tuberculosis sensitive to antibacterial drugs. The patients with drug-resistant bacteria before hospitalization had lower count of T-lymphocytes, altered proportion T-helpers/T-suppressors, reduced ability of T-lymphocytes for blast transformation in the presence of PHA and PPD. T-lymphocyte functional activity remained inhibited as compared to those patients discharging drug-sensitive mycobacteria.
authors: N V
authors: NV
authors: Kuz'mina
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology*; D016516:CD4-CD8 Ratio; D004352:Drug Resistance, Microbial; D006801:Humans; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000995:Antitubercular Agents
vernacular_title: Immunologicheskie pokazateli u bol'nykh tuberkulezom legkikh pri lekarstvennoĭ ustoĭchivosti mikobakteriĭ.