title: Chemokines: progress toward identifying molecular targets for therapeutic agents.
abstract: Leukocyte migration towards injury sites is directed by the interaction of chemokines with their receptors. The stages of migration are closely regulated events that involve chemokine-induced leukocyte adhesion, diapedesis and homing. Current research suggests a pathophysiological role for chemokines in diverse inflammatory states arising from viral, bacterial and parasitic infection, allergic and asthmatic reactions, atherosclerosis and arthritis. A role for chemokines in tumor immunity and angiogenesis has recently been demonstrated. A basis for the rational design of chemokine antagonists is emerging from a knowledge of tertiary structures and mutational analysis of chemokine ligands and receptors. Here, we discuss advances in knowledge about chemokine structure and function, with emphasis on potential therapeutic agents.
authors: SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201, USA.
authors: O M
authors: OM
authors: Howard
authors: A
authors: A
authors: Ben-Baruch
authors: J J
authors: JJ
authors: Oppenheim
mesh_terms: D001161:Arteriosclerosis / Q000503:physiopathology / Q000628:therapy; D001168:Arthritis / Q000503:physiopathology / Q000628:therapy; D001249:Asthma / Q000503:physiopathology / Q000628:therapy; D001424:Bacterial Infections / Q000503:physiopathology / Q000628:therapy; D018925:Chemokines / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology / Q000628:therapy; D007249:Inflammation; D010272:Parasitic Diseases / Q000503:physiopathology / Q000628:therapy; D011971:Receptors, Immunologic / Q000737:chemistry / Q000502:physiology*; D011994:Recombinant Proteins / Q000737:chemistry / Q000627:therapeutic use*; D014777:Virus Diseases / Q000503:physiopathology / Q000628:therapy
chemical_list: D018925:Chemokines; D011971:Receptors, Immunologic; D011994:Recombinant Proteins