title: Fish oil may be an antidote for the cardiovascular risk of smoking.
abstract: The fact that the cardiovascular risk of ex-smokers approximates that of non-smokers after two years of abstinence, implies that accelerated atherogenesis is not the chief mechanism of smoking-related heart disease. Indeed, smoking or nicotine have adverse effects on blood rheology, thrombotic risk, coronary blood flow, and risk for arrhythmias. Omega-3-rich fish oils can be expected to correct or compensate for a remarkable number of the adverse impacts of smoking/nicotine: increased plasma fibrinogen, decreased erythrocyte distensibility, increased plasma and blood viscosity, increased platelet aggregability, increased plasminogen activator inhibitor levels, vasoconstriction of the coronary bed, reduced fibrillation threshold, increased triglycerides, reduced high-density lipoprotein cholesterol, and increased production of superoxide by phagocytes. Smokers who cannot overcome their addiction should be encouraged to substitute nicotine aerosols/gum for tobacco and advised to use supplementary fish oil and other cardioprotective nutrients.
authors: Nutrition 21, San Diego, CA 92109, USA.
authors: M F
authors: MF
authors: McCarty
mesh_terms: D000931:Antidotes / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control; D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control*; D005340:Fibrinogen / Q000378:metabolism; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D008954:Models, Biological; D009538:Nicotine / Q000009:adverse effects; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism / Q000503:physiopathology; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D014661:Vasoconstriction
chemical_list: D000931:Antidotes; D005395:Fish Oils; D009538:Nicotine; D005340:Fibrinogen