[The structural component of the vascular adrenoreactivity of the skeletal muscles in normo- and hypertensive rats].
In anesthetized normotensive (WKY) and spontaneously hypertensive (SHR) rats the adrenoreactivity in the maximum dilated vessels of hind leg skeletal muscles was compared. Adrenoreactivity mentioned above has been registered as an amplitude of changes of hydraulic resistance (R), hydrostatic capillary pressure (Pc) and capillary filtration coefficient (CFC) to noradrenaline infusion in the vascular bed of perfused skeletal muscles. Resistance changes were more considerable in experiments on the SHR comparatively to those in the WKY. Changes of CFC as well as Pc in both strains were not statistically differed. The data obtained confirm Folkow's hypothesis about increased adrenoreactivity of the resistance vessels in hypertensive mammals due to structural changes of the vascular bed.
Dvoretskiĭ
D P
DP
Matchanov
A T
AT
Shustova
N Ia
NIa
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D005260:Female; D006614:Hindlimb; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion / Q000379:methods; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D000316:Adrenergic alpha-Agonists; D011942:Receptors, Adrenergic, alpha; D009638:Norepinephrine
Strukturnyĭ komponent adrenoreaktivnosti sosudov skeletnykh myshts normo- i gipertenzivnykh krys.