[The changes in collagen contents and its clinical significance in chronic obstructive pulmonary disease].
Type III procollagen (P IIIP) hyaluronic acid (HA) and fibronectin (Fn) were assayed in patients with COPD, with radio-immunoassay (RIA). The results were shown as follows: The mean levels of P IIIP, HA were significantly higher than those of normal (P < 0.05, < 0.05). Plasma Fn was consistantly in lower level in COPD (P < 0.05). It is suggested that P IIIP, HA and Fn played a role in development of pulmonary fibrosis and quantification of such collagen contents may be a sensitive index to assess the degree of pulmonary fibrosis and to predict the prognosis of patients with COPD.
Dong
B
B
First Hospital, West China University of Medical Sciences, Chengdu.
Zhou
J
J
Wang
Z
Z
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011347:Procollagen / Q000097:blood*; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000209:etiology; D011863:Radioimmunoassay
D005353:Fibronectins; D011347:Procollagen; D006820:Hyaluronic Acid