title: Canine distemper virus in Lake Baikal seals (Phoca sibirica).
abstract: The virus epizootic which resulted in significant mortality in Siberian seals (Phoca sibirica) in Lake Baikal during 1987/88 was caused by canine distemper virus. Sequence analysis of the virus glycoprotein genes revealed that it was most closely related to recent European field isolates of canine distemper virus. This paper presents evidence that the same virus continued to circulate in seals in Lake Baikal after the initial epizootic. Three out of 45 brain tissue samples collected from seals culled in the spring of 1992 were positive for canine distemper virus-specific nucleic acid by the reverse transcription/polymerase chain reaction and the sequences were closely related to that of the original virus isolated in 1988.
authors: Limnological Institute, Irkutsk, Russia.
authors: L V
authors: LV
authors: Mamaev
authors: I K
authors: IK
authors: Visser
authors: S I
authors: SI
authors: Belikov
authors: N N
authors: NN
authors: Denikina
authors: T
authors: T
authors: Harder
authors: L
authors: L
authors: Goatley
authors: B
authors: B
authors: Rima
authors: B
authors: B
authors: Edginton
authors: A D
authors: AD
authors: Osterhaus
authors: T
authors: T
authors: Barrett
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary*; D004216:Distemper / Q000453:epidemiology / Q000821:virology*; D004217:Distemper Virus, Canine / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D008969:Molecular Sequence Data; D046048:Seals, Earless / Q000821:virology*; D012689:Sequence Homology, Nucleic Acid; D012800:Siberia / Q000453:epidemiology; D014765:Viral Vaccines / Q000235:genetics*
chemical_list: D014765:Viral Vaccines