Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis.
Thirteen normal adult donors underwent daily leukapheresis for peripheral blood progenitor cell collection for allografting beginning on day 4 or 5 of G-CSF mobilization (12 micrograms/kg/d). They had complete blood counts performed 7-10 d after the completion of the procedure. A reduction in the total leucocyte count below baseline levels, accounted for by a decrease in the absolute neutrophil (ANC) and lymphocyte counts, was noted. Neutropenia (ANC < 1.5 x 10(9)/l) occurred in two (15%) of the donors. The lowest ANC observed was 0.6 x 10(9)/l. The neutropenia was asymptomatic and resolved on follow-up evaluation.
Anderlini
P
P
Department of Hematology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Przepiorka
D
D
Seong
D
D
Champlin
R
R
Körbling
M
M
D000293:Adolescent; D000328:Adult; D001781:Blood Component Removal / Q000009:adverse effects; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000494:pharmacology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology*; D014019:Tissue Donors; D014182:Transplantation, Autologous
D016179:Granulocyte Colony-Stimulating Factor