[The concepts and conceptual models of psychopharmacology].
The present approaches to the testing and use of drugs, psychotropic ones in particular, are characterized by inadequate efficiency: the ratio of agents successfully undergone preclinical, clinical, and postclinical tests is 100:5:1 and in clinical psychopharmacotherapy, the proportion of drug-resistant patients and the incidence of side effects are rather high. The groundless supposition that interspecies- and intraspecies-specific sensitivity to drugs is equal may explain this notion, which contradicts the concept of the biochemical stability of species and to the principle of molecular economy in species-specific ratios. To enhance the efficiency of tests and pharmacotherapy, it is suggested that the existing conceptual model "concentration-effect" should be replaced by the extended one "sensitivity-concentration-effect" as it is more scientifically substantiated. Increases in the efficiency of psychopharmacotherapy may be, among other things, reached by individually predicting the most effective psychotropic agents with clinical, paraclinical, pharmacokinetic, and other predictors.
Gor'kov
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VA
D000818:Animals; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008954:Models, Biological; D011600:Psychopharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology / Q000627:therapeutic use
D011619:Psychotropic Drugs
Kontseptsii i kontseptual'nye modeli psikhofarmakologii.