title: Differential expression of inducible nitric oxide synthase mRNA in human brain tumours.
abstract: Messenger RNA encoding the inducible form of human nitric oxide synthase (iNOS) was quantified by reverse transcription and polymerase chain reaction (RT-PCR) in tissue samples from glioblastomas and meningiomas. iNOS mRNA expression was considerably higher in the glioblastoma than in the meningioma specimens (mean +/- s.e.m., 41.18 +/- 11.5, n = 25, vs 5.31 +/- 0.98, n = 21; p < 0.0001). Moreover, iNOS expression appeared as a polymorphic character among glioblastomas, as individual tumours expressed either high (n = 6), intermediate (n = 10) or low (n = 9) levels of iNOS mRNA.
authors: INSERM U-394 Neurobiologie Intégrative, Domaine de Carreire, Bordeaux, France.
authors: E
authors: E
authors: Ellie
authors: H
authors: H
authors: Loiseau
authors: F
authors: F
authors: Lafond
authors: J
authors: J
authors: Arsaut
authors: J
authors: J
authors: Demotes-Mainard
mesh_terms: D001483:Base Sequence; D001932:Brain Neoplasms / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D008579:Meningioma / Q000378:metabolism*; D008969:Molecular Sequence Data; D019001:Nitric Oxide Synthase / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis*
chemical_list: D012333:RNA, Messenger; D019001:Nitric Oxide Synthase