[A trial of the efficacy of using the synthetic antioxidant dibunol in the chemotherapy of experimental tumors].
We studied the therapeutic efficiency of the synthetic antioxidant Dibunol alone and in combination with cytostatic drugs on animals with experimental tumors after simultaneous and successive administration. Introduction of Dibunol to animals (tumor carriers) soon after the transplantation of tumor cells had adverse consequences, stimulated tumor growth and reduced the life span of animals. Dibunol exerted a therapeutic effect only in cases of developed tumors. Simultaneous introduction of cytostatic drugs (cyclophosphamide, dimethylnitrosourea, ADEKO) and Dibunol to tumor carriers was efficient and increased the mean life span of animals. The antitumor effect of the cyclophosphamide-Dibunol combination did not, in practice, depend on the interval between introductions of these drugs. However, the mean life span and survival of animals were somewhat higher the intervals between introductions or simultaneous application of the drugs were short.
Krutova
T V
TV
Bogoslovskaia
E P
EP
Ostrovskaia
L A
LA
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000401:mortality; D003520:Cyclophosphamide / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000401:mortality; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000031:analogs & derivatives; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; D000975:Antioxidants; C001049:N,N'-dimethylnitrosourea; D002084:Butylated Hydroxytoluene; D008770:Methylnitrosourea; C042070:ADEKO; D003520:Cyclophosphamide
Opyt éffektivnosti primeneniia sinteticheskogo antioksidanta dibunola pri khimioterapii éksperimental'nykh opukholeĭ.