[Activity of Na+, K+-ATP-ase isoenzymes in the cerebral cortex and their sensitivity to sodium dodecyl sulfate in rat postnatal ontogenesis].
The comparative study of activities of Na+, K(+)-ATPase alpha (+)- and alpha-isozymes in rat brain cortex in the postnatal period is conducted. It is shown, that the rates of isozymes expression are not different and levels of their activities reach maximum to the 30th day after birth. Na(+), K(+)-ATPase resistance to SDS inactivation increases with the age, that reflects possible changes in the peculiarities in structural organization of isozymes protein-lipid complex. Results are discussed from the view point of the adaptive changes in the process of structural-metabolic organization of biomembrane function occurring in ontogenesis.
Kaplia
A A
AA
Kravtsov
A V
AV
Kravtsova
V V
VV
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D004795:Enzyme Stability; D007527:Isoenzymes / Q000187:drug effects* / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D011506:Proteins / Q000737:chemistry; D051381:Rats; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000378:metabolism
D007527:Isoenzymes; D008055:Lipids; D011506:Proteins; D012967:Sodium Dodecyl Sulfate; D000254:Sodium-Potassium-Exchanging ATPase
Aktivnost' izofermentov Na+, K+-ATP-azy kory golovnogo mozga i ikh chuvstvitel'nost' k dodetsisul'fatu natriia v postnatal'nom ontogeneze krys.