title: Ventilatory response to cholecystokinin tetrapeptide in anaesthetized dogs.
abstract: Cholecystokinin (CCK) has been implicated in the genesis of panic disorder. In this study we measured the ventilatory response to i.v. injection of CCK-tetrapeptide (CCK-4) in anaesthetized dogs. We found an immediate and transient increase in minute ventilation. The response was large (more than 100% of baseline) and lasted 1-2 min. Repeated CCK-4 injection produced a somewhat reduced response, suggestive of a slight degree of tachyphylaxis. Blood pressure and heart rate changed only slightly (<10%), while respiratory mechanical parameters remained unchanged following CCK-4 administration. We conclude that CCK-4 has a significant effect on ventilation in the anaesthetized dog, which suggests that this species may provide a useful quantitative assay for the anxiogenic effects of CCK.
authors: Meakins-Christie Laboratories of the Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
authors: J H
authors: JH
authors: Bates
authors: J
authors: J
authors: Bradwejn
mesh_terms: D000818:Animals; D004285:Dogs; D007275:Injections, Intravenous; D016584:Panic Disorder / Q000378:metabolism; D012119:Respiration / Q000187:drug effects*; D013758:Tetragastrin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013758:Tetragastrin