[Pathogenesis of Guillain-Barré syndrome and Fisher's syndrome: molecular mimicry between antecedent infectious agents and components of nerve tissues].
Sera from patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni infection have autoantibody to GM1 ganglioside. We have investigated whether GM1-oligosaccharide structure is present in the lipopolysaccharide (LPS) of C. jejuni (PEN 19) that was isolated from a GBS patient. The LPS showing the binding activity of cholera toxin, which specifically recognizes the GM1-oligosaccharide, was purified by a column chromatography. Proton NMR methods have revealed that the LPS has the oligosaccharide structure [Gal beta 1-3GalNAc beta 1-4 (NeuAc alpha 2-3) Gal beta 1-], which is identical to the terminal tetrasaccharide of GM1 ganglioside. Fisher's syndrome (FS) is very frequently associated with anti-GQ1b ganglioside antibody. We isolated C. jejuni from 2 patients with FS subsequent to enteritis. Crude LPS fractions were extracted from the bacteria and separated by thin-layer chromatography. Monoclonal antibodies to GQ1b ganglioside (GMR 13 and 7F5) reacted with both LPS fractions, indicating that the LPSs bear GQ1b epitope. These findings strongly support that "molecular mimicry" between infectious agents and components of nervous system function in the development of post-infection disorders.
Yuki
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Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University.
D001323:Autoantibodies; D002169:Campylobacter Infections / Q000150:complications; D016123:Campylobacter jejuni; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D018716:Molecular Mimicry; D011129:Polyradiculoneuropathy / Q000209:etiology*; D013577:Syndrome
D001323:Autoantibodies; D005732:Gangliosides; D008070:Lipopolysaccharides