RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors.
The locomotor response to RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole; 10 mg/kg, s.c.), a preferential 5-HT(1B) receptor agonist, was investigated in the rat, using two novel 5-HT(1A) receptor antagonists, WAY-100635 (0.3 mg/kg and 1 mg/kg, s.c.) and SDZ 216-525 (0.3 mg/kg, s.c.), and the novel 5-HT(1B)/5-HT(1D) receptor antagonist, GR 127935 (1 mg/kg, s.c.). The antagonists per se did not alter spontaneous locomotion. Both selective 5-HT(1A) receptor antagonists blocked RU 24969-induced hyperlocomotion, whilst the 5-HT(1B) receptor antagonist was without effect. These results suggest that RU 24969-induced hyperlocomotion in the rat is mediated by 5-HT(1A) receptors.
Kalkman
H O
HO
Sandoz Pharma, Basel, Switzerland.
D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology
D007211:Indoles; D010879:Piperazines; D011725:Pyridines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D013844:Thiazoles; C080378:SDZ 216-525; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide