The sequence of 12.8 kb from the left arm of chromosome XIV reveals a sigma element, a pro-tRNA and six complete open reading frames, one of which encodes a protein similar to the human leukotriene A4 hydrolase.
We have determined the nucleotide sequence of a 12.8 kb fragment from the left arm of chromosome XIV carried by the cosmid 14-16d. An analysis of the sequence reveals the presence of a sigma element, a pro-tRNA gene and eight open reading frames, six of which are complete. All of the eight open reading frames correspond to new genes. Of the eight new genes, two show strong similarities to a pair of new genes from chromosome IX, suggesting an ancestral duplication, and one gene encodes a protein similar to mammalian leukotriene A4 hydrolase.
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Centre de Génétique Moléculaire, Laboratoire propre du CNRS associé à l'Université Pierre et Marie Curie, Gif-sur-Yvette, France.
Bécam
A M
AM
Herbert
C J
CJ
D000595:Amino Acid Sequence; D015825:Chromosomes, Fungal / Q000235:genetics*; D018360:Crystallography, X-Ray; D004851:Epoxide Hydrolases / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics*; D012331:RNA, Fungal / Q000235:genetics; D012346:RNA, Transfer, Amino Acyl / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012808:Sigma Factor / Q000235:genetics
D005656:Fungal Proteins; D012331:RNA, Fungal; D012346:RNA, Transfer, Amino Acyl; D012808:Sigma Factor; D004851:Epoxide Hydrolases; C043134:leukotriene A4 hydrolase