title: Indocyanine green and fluorescein angiography of surgically excised macular choroidal neovascularizations: correlations with histopathologic and ultrastructural findings.
abstract: BACKGROUND
  Informations are expected from the histopathological study of surgically excised choroidal neovascular membranes (CNMs), particularly in relation to the angiographic aspects of vascular architecture.
  
  
  METHODS
  Fluorescein and indocyanine green (ICG) angiograms were studied together with the histopathological features of 12 surgically excised subfoveal CNMs in eyes affected by age-related macular degeneration (ARMD).
  
  
  RESULTS
  Instead of the early and delayed diffuse hyperfluorescence secondary to CNMs observed on fluorescein angiography (seven were well defined, five scar evolved), ICG revealed (a) very early hypofluorescence of the membrane bulk over the fluorescence of the outer choroidal vascular bed and (b) late hyperfluorescence gradually increasing and partially defining the border of membranes. CNMs with well-defined hyperfluorescent aspects were characterized by fibrovascular bulk lined on one side by retinal pigment epithelium. Fibrosis reaction predominated over the vascular components in scar-evolved membranes.
  
  
  CONCLUSIONS
  Fluorescein and ICG angiographic differences in the appearance of CNMs could depend on (a) the morphological structure and size of the CNM (b) its location within the chorioretinal layers and (c) different molecular characteristics of the dyes used.
authors: Department of Ophthalmology and Visual Sciences, Scientific Institute H San Raffaele, University of Milan, Italy.
authors: G
authors: G
authors: Trabucchi
authors: R
authors: R
authors: Brancato
authors: V
authors: V
authors: De Molfetta
authors: M
authors: M
authors: Verdi
authors: A
authors: A
authors: Pece
authors: U
authors: U
authors: Introini
authors: P
authors: P
authors: Avanza
authors: G
authors: G
authors: Modorati
authors: P
authors: P
authors: Airaghi
mesh_terms: D000368:Aged; D002829:Choroid / Q000098:blood supply* / Q000648:ultrastructure*; D005260:Female; D005355:Fibrosis; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000150:complications; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure
chemical_list: D007208:Indocyanine Green