Antenatal invasive and noninvasive management of alloimmune thrombocytopenia.
The outcome analysis of 10 pregnancies at risk for neonatal alloimmune thrombocytopenia (NAIT) is presented. An experimental protocol of cordocentesis and maternal administration of intravenous immunoglobulin (IVIG) is compared to a control group of older untreated affected siblings. The outcome in pregnancies treated with IVIG shows improved fetal platelet count in 70% and no intraventricular hemorrhage. We conclude that maternal administration of IVIG appears to improve clinical outcome in fetuses at risk for NAIT.
Kornfeld
I
I
Division of Maternal-Fetal Medicine, British Columbia Women's Hospital, University of British Columbia, Vancouver, Canada.
Wilson
R D
RD
Ballem
P
P
Wittmann
B K
BK
Farquharson
D F
DF
D002543:Cerebral Hemorrhage / Q000209:etiology; D017218:Cordocentesis; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007518:Isoantibodies; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies