title: Enhanced vesiculation exacerbates complement-dependent hemolysis in glucose-6-phosphate dehydrogenase deficient red blood cells.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficient RBCs to Ca(2+)-induced vesiculation is not due to ATP depletion. The remnant G6PD-deficient RBCs following vesiculation are more sensitive to complement-mediated hemolysis than control normal RBCs. A strong positive correlation exists between the level of Ca(2+)-induced vesiculation and the extent of complement mediated hemolysis.
authors: Chang Gung College of Medicine, Kwei-Shan, Tao-Yuan, Taiwan.
authors: K J
authors: KJ
authors: Tsai
authors: L Y
authors: LY
authors: Shih
authors: I J
authors: IJ
authors: Hung
authors: S W
authors: SW
authors: Huang
authors: J S
authors: JS
authors: Wei
authors: T Z
authors: TZ
authors: Liu
authors: D T
authors: DT
authors: Chiu
mesh_terms: D002118:Calcium / Q000378:metabolism; D003165:Complement System Proteins / Q000502:physiology*; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood*; D006461:Hemolysis; D006801:Humans; D011770:Pyruvate Kinase / Q000378:metabolism
chemical_list: D003165:Complement System Proteins; D005954:Glucosephosphate Dehydrogenase; D011770:Pyruvate Kinase; D002118:Calcium