Expression and long-term prognostic value of CD34 in childhood and adult acute lymphoblastic leukemia.
Clinical and laboratory characteristics at diagnosis, and long-term (up to 7 years) evolution, were analysed in 156 patients (66 adults and 90 children) with acute lymphoblastic leukemia (ALL), according to the expression of CD34. Eighty-three patients had CD34+ and 73 patients CD34- blasts at diagnosis. In adults, CD34+ ALL was more often of B-lineage (p = .003). White blood cell counts were higher both in children with CD34-B-lineage ALL (p = .02) and adults with CD34-T-lineage ALL (p - .05). Adult patients with CD34-T-lineage ALL were older (p = .04) and had more frequent splenic or liver enlargement (p = .02). Children with CD34+ ALL had a significantly (p = .04) longer event-free follow-up than CD34- children. Survival curves showed that after induction of remission, relapses were less frequent during the first 2 years for patients with CD34+ B-lineage ALL. After 2 years, however, event-free survival curves of CD34+ and CD34- patients merged. Thus it seems that CD34+ has no significant benefit for ALL patients.
Vanhaeke
D R
DR
Laboratoire d'Hématologie, Hôpital Cimiez, Nice, France.
Béné
M C
MC
Garand
R
R
Faure
G C
GC
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis; D018952:Antigens, CD34 / Q000032:analysis* / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012727:Sex Characteristics; D012737:Sex Factors; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D015703:Antigens, CD; D018952:Antigens, CD34; D015415:Biomarkers