Spinal anaesthesia induced by intrathecal magnesium sulphate.
We have demonstrated in a rat model that the intrathecal injection of 0.02 ml of 6.3% magnesium sulphate, a concentration iso-osmolar with rat plasma, will produce a state of spinal anaesthesia and general sedation, lasting approximately 1 h. These effects reversed completely after 6 h, without evidence of neurotoxicity, immediately or during the period 1 week following the injection. The accompanying changes in haemodynamic and respiratory functions were minimal throughout the period of anaesthesia and compare favourably with those induced by an intrathecal bolus of 0.04 ml of 2% lignocaine.
Bahar
M
M
Department of Anaesthesiology, Tel-Aviv University, Israel.
Chanimov
M
M
Grinspun
E
E
Koifman
I
I
Cohen
M L
ML
D000775:Anesthesia, Spinal / Q000379:methods*; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects; D007700:Kinetics; D008278:Magnesium Sulfate / Q000494:pharmacology; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects
D000777:Anesthetics; D002245:Carbon Dioxide; D008278:Magnesium Sulfate; D010100:Oxygen