Selective cyclooxygenase-2 inhibition reduces carrageenan oedema and associated spinal c-Fos expression in the rat.
Pre-administered NS-398 (0.1, 1 and 10 mg/kg p.o.), a selective cyclooxygenase-2 inhibitor without gastro-intestinal side-effects, dose-dependently reduced carrageenan evoked spinal c-Fos expression (16 +/- 4%, 32 +/- 3% and 56 +/- 5% reduction, respectively) at 3 h after intraplantar carrageenan. The effects of NS-398 on carrageenan induced peripheral oedema and spinal c-Fos expression were correlated, thus demonstrating the beneficial relief of inflammatory pain.
Buritova
J
J
Laboratoire de Physiopharmacologie du Système Nerveux, INSERM U161 and EPHE, Paris, France.
Chapman
V
V
Honoré
P
P
Besson
J M
JM
D000818:Animals; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005528:Foot / Q000473:pathology; D006614:Hindlimb / Q000473:pathology; D008297:Male; D009578:Nitrobenzenes / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D013449:Sulfonamides / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D009578:Nitrobenzenes; D016760:Proto-Oncogene Proteins c-fos; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D002351:Carrageenan