Lactoferrin lowers the incidence of positive Coombs' test in New Zealand black mice.
The results presented in this communication show that New Zealand Black (NZB) mice treated for a prolonged period with bovine lactoferrin (BLF) exhibit a decreased frequency of positive Coombs' reaction. This effect was dose dependent and best pronounced at a dose of 50 micrograms/dose. We found, in addition, that incubation of peritoneal cells with BLF resulted in a decreased number of cells recognizing Hb antigen on autologous erythrocytes. The data indicated that lactoferrin may be of therapeutical value in treatment of autoimmune disorders.
Zimecki
M
M
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Wieczorek
Z
Z
Mazurier
J
J
Spik
G
G
D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D003298:Coombs Test; D004305:Dose-Response Relationship, Drug; D005260:Female; D007781:Lactoferrin / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008814:Mice, Inbred NZB
D007781:Lactoferrin