title: Cyclosporine A shows immunosuppressor activity on T lymphocytes from the peripheral blood and synovial fluid of patients with autoimmune arthritis.
abstract: OBJECTIVE
  This work studies the effects of Cyclosporine A (CsA) upon the activation and proliferation of mononuclear cells (MNC) from the peripheral blood (PB) of patients with chronic autoimmune arthritis and from healthy controls, and from the synovial fluid (SF) of patients.
  
  
  METHODS
  In vitro studies of activation, proliferation, mRNA expression and lymphokine production were carried out.
  
  
  RESULTS
  We found in the PB and SF MNCs from patients with autoimmune arthritis that CsA inhibits the proliferative response, activation antigen expression, IL-2 mRNA expression and IL-2 production induced by polyclonal mitogens in a dose dependent manner.
  
  
  CONCLUSIONS
  CsA blocks lymphocyte activation in PB and SF MNCs from patients with autoimmune arthritis.
authors: Servicio de Enfermedades del Sistema Immune, Hospital Universitario Principe de Asturias, Spain.
authors: C
authors: C
authors: Guillen
authors: A
authors: A
authors: Prieto
authors: M
authors: M
authors: Perez-Blas
authors: M
authors: M
authors: Alvarez de Buergo
authors: L
authors: L
authors: Villa
authors: H
authors: H
authors: Rico
authors: A
authors: A
authors: Zea
authors: M
authors: M
authors: Alvarez-Mon
mesh_terms: D000941:Antigens / Q000032:analysis; D001168:Arthritis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D001483:Base Sequence; D001773:Blood Cells / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D016572:Cyclosporine / Q000627:therapeutic use*; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007376:Interleukin-2 / Q000235:genetics; D008297:Male; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D013582:Synovial Fluid / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D000941:Antigens; D016207:Cytokines; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D015335:Molecular Probes; D012333:RNA, Messenger; D016572:Cyclosporine