[Clinical significance of serum soluble interleukin-2 receptor (sIL-2R) determination in patients with rheumatoid arthritis].
It has been recently shown that soluble interleukin-2 receptor (sIL-2R) is related to the pathogenesis of autoimmune diseases. We determined serum levels of sIL-2R in patients with rheumatoid arthritis (RA). Fifty-three patients (3 males and 50 females from 35 to 70 years old) and sex- and age-matched 50 healthy subjects were included in this study. The sIL-2R concentrations positively correlated with Lansbury index of RA (r = 0.602, p < 0.01). There was a significant correlation between sIL-2R levels and the prevalence of CD3+.HLA-DR+ lymphocytes (r = 0.420, p < 0.01).
Takemura
M
M
Central Clinical Laboratory, Gifu University Hospital.
Seishima
M
M
Noma
A
A
Kasai
C
C
Satoh
M
M
Morita
T
T
Takeuchi
S
S
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D017252:CD3 Complex; D005260:Female; D006684:HLA-DR Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012720:Severity of Illness Index; D012995:Solubility; D013601:T-Lymphocytes
D017252:CD3 Complex; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2