Non-islet cell tumour-associated hypoglycaemia: 111In-octreotide imaging and efficacy of octreotide, growth hormone and glucocorticosteroids.
A patient presented with frequent episodes of spontaneous hypoglycaemia due to a solitary fibrous tumour of pleural origin, secreting incompletely processed pro-insulin-like growth factor II (big IGF-II). Somatostatin receptors were demonstrated in the tumour by 111 inlabelled octreotide scintigraphy, but despite maximal doses of octreotide, there was no suppression of big IGF-II secretion and the hypoglycaemia persisted. The combination of GH and glucocorticoid therapy abolished the hypoglycaemia.
Perros
P
P
Metabolic Unit, Western General Hospitals NHS Trust, Edinburgh, UK.
Simpson
J
J
Innes
J A
JA
Teale
J D
JD
McKnight
J A
JA
D000368:Aged; D001539:Bendroflumethiazide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D015282:Octreotide / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011498:Protein Precursors / Q000378:metabolism; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis; D013004:Somatostatin / Q000627:therapeutic use
D005938:Glucocorticoids; D011498:Protein Precursors; D017481:Receptors, Somatostatin; C066038:proinsulin-like growth factor II; D013004:Somatostatin; D001539:Bendroflumethiazide; D007335:Insulin-Like Growth Factor II; D011239:Prednisolone; D015282:Octreotide