Pulmonary arterial contribution to airway blood flow after lung transplantation in dogs.
Despite the improved success of lung transplantation, ischemia of the donor bronchus continues to be the most important factor influencing airway healing. Recent studies have shown that at the level of the mainstem bronchi the pulmonary contribution to the airway blood flow may be equivalent to or greater than the systemic contribution and could therefore assist early healing of the newly anastomosed bronchus and, in addition, might facilitate the improved healing associated with omentopexy. The aim of this study was to measure the pulmonary contribution to airway blood flow in dogs after allotransplantation of the left lung and to determine whether omentopexy might improve the healing process. Using the radioactive microsphere technique, we measured the pulmonary contribution to airway blood flow in 25 dogs 1 week after allotransplantation of the left lung. Half the dogs had an omental wrap around the anastomotic site. Results showed that pulmonary blood flow increased progressively from lower trachea to distal mainstem bronchus and supplied the left mainstem bronchus above as well as below the anastomotic site. Omentopexy did not increase flow or enhance healing.
Baile
E M
EM
Department of Experimental Surgery, National Institute of Respiratory Diseases, Tlalpan, Mexico.
Sotres-Vega
A
A
Jasso-Victoria
R
R
Olmos
R
R
Arreola
J L
JL
Chan
N
N
Pare
P D
PD
Santillan-Doherty
P
P
D000818:Animals; D004285:Dogs; D006084:Graft Rejection; D008168:Lung / Q000098:blood supply; D016040:Lung Transplantation / Q000473:pathology / Q000502:physiology*; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D011651:Pulmonary Artery / Q000502:physiology*; D011652:Pulmonary Circulation; D013902:Radiography, Thoracic; D012039:Regional Blood Flow; D012044:Regression Analysis; D014184:Transplantation, Homologous