title: Progressive deterioration of intellect and motor function occurring several decades after cranial irradiation. A new facet in the clinical spectrum of radiation encephalopathy.
abstract: OBJECTIVE
  To report the cases of 2 patients who developed the features of radiation encephalopathy 33 and 28 years after cranial irradiation.
  
  
  METHODS
  Case reports; clinical data were available for 2 years in each instance.
  
  
  CONCLUSIONS
  Latent intervals approaching 2 decades have been reported in cases of radiation necrosis following cranial irradiation, but a similar or greater delay before the onset of radiation encephalopathy has not been described previously. This report indicates that a diagnosis of radiation encephalopathy must be considered when any individual who has received cranial irradiation presents with deterioration in intellectual or motor function, whatever the interval.
authors: Department of Neurology, Royal Victoria Infirmary, Newcastle Upon Tyne, England.
authors: P
authors: P
authors: Duffey
authors: G
authors: G
authors: Chari
authors: N E
authors: NE
authors: Cartlidge
authors: P J
authors: PJ
authors: Shaw
mesh_terms: D000328:Adult; D001921:Brain / Q000528:radiation effects*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000528:radiation effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed