Serum-sickness-like reaction associated with minocycline therapy in adolescents.
OBJECTIVE
To describe a serum-sickness-like reaction in five adolescents treated with minocycline.


METHODS
Five adolescents developed a rash and arthralgias/arthritis after taking minocycline for 10-30 days. Symptoms resolved gradually after the medication was stopped.


CONCLUSIONS
Serum sickness is not described in the pharmacology literature as an adverse effect of minocycline, and in the English literature there are only two case reports. The migration inhibitory factor assay and mast cell degranulation test were positive in four of the five patients. The results of these assays were consistent with a role for minocycline in causing these reactions.


CONCLUSIONS
Clinicians should be aware of the possibility of serum-sickness-like reaction as an adverse effect of minocycline.
Harel
L
L
Department of Pediatrics C, Children's Medical Center of Israel, Petah Tiqva, Israel.
Amir
J
J
Livni
E
E
Straussberg
R
R
Varsano
I
I
D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D012713:Serum Sickness / Q000139:chemically induced* / Q000276:immunology
D008263:Macrophage Migration-Inhibitory Factors; D008911:Minocycline