[Effect of Chinese herbal medicine of tonifying kidney on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice].
Dementia mimetic mouse model was formed with aluminum chloride solution in order to study the effect of Chinese herbal medicine of tonifying Kidney (TK) on the M-cholinergic receptor (Rt) and the acetylcholinesterase (AchE) activity in the model's cerebral cortex. Results showed that the M-cholinergic receptor Rt lowered and the AchE increased in the model evidently as compared with the healthy young mice. The TK could markedly reduce the increased AchE and elevate the lowered M-cholinergic receptor Rt in cerebral cortex of the dementia mimetic mice, it also could improve the memory. These results suggest that TK is effective in preventing the degeneration of cerebral function and presenile dementia.
Mo
Q
Q
Nuclear Medicine Laboratory of Shanghai University of TCM.
Ma
J
J
Gong
B
B
D000110:Acetylcholinesterase / Q000378:metabolism*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D002712:Chlorides; D003704:Dementia / Q000139:chemically induced / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D011976:Receptors, Muscarinic / Q000378:metabolism*
D017607:Aluminum Compounds; D002712:Chlorides; D004365:Drugs, Chinese Herbal; D011976:Receptors, Muscarinic; D000077410:Aluminum Chloride; D000110:Acetylcholinesterase