title: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.
abstract: During Drosophila neurogenesis, differential segregation of Numb is necessary for daughter cells of asymmetric divisions to adopt distinct fates, at least partly by biasing the Notch-mediated cell-cell interaction. We have isolated a highly conserved mammalian homolog of Drosophila numb, m-numb. During mouse cortical neurogenesis, m-Numb is asymmetrically localized to the apical membrane of dividing ventricular neural progenitors. Depending upon the orientation of the cleavage plane, m-Numb may be distributed into one or both of the daughter cells. When expressed in Drosophila embryos, m-Numb is localized asymmetrically in dividing neural precursors and rescues the numb mutant phenotype. Furthermore, m-Numb can physically interact with mouse Notch1. We propose that some shared molecular mechanisms, both cell-intrinsic and cell-extrinsic, generate asymmetric cell divisions during neurogenesis of vertebrates and invertebrates.
authors: Howard Hughes Medical Institute, University of California, San Francisco 94143-0724, USA.
authors: W
authors: W
authors: Zhong
authors: J N
authors: JN
authors: Feder
authors: M M
authors: MM
authors: Jiang
authors: L Y
authors: LY
authors: Jan
authors: Y N
authors: YN
authors: Jan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D004330:Drosophila; D029721:Drosophila Proteins; D004622:Embryo, Mammalian / Q000378:metabolism; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice / Q000196:embryology*; D008969:Molecular Sequence Data; D009154:Mutation; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D051880:Receptors, Notch; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
chemical_list: D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008565:Membrane Proteins; C497759:N protein, Drosophila; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; C060606:numb protein, Drosophila