[Experimental research of the effect of physical training on brain aging].
Physical training is an important means modifying brain aging. Using behavioral, morphological and biological methods, the present study investigated the effect of prolonged training (running wheel for 8 and 19 months), initiated at 5 months of age, on age-related changes of motor-associated centers in the mouse. The results suggested that a moderate amount of prolonged physical training could modify the age-related degenerative changes of morphology and function of neurons in motor-associated centers and improve the function of neurons through the stimulation of the compensation of neurons.
Chen
Y C
YC
Department of Anatomy, Sun Yat-sen University of Medical Sciences, Guangzhou.
D000109:Acetylcholine / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology / Q000502:physiology*; D016922:Cellular Senescence; D002525:Cerebellar Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D016708:Synaptophysin / Q000378:metabolism
D016708:Synaptophysin; D000109:Acetylcholine