Dual inhibitors of enkephalin-degrading enzymes (neutral endopeptidase 24.11 and aminopeptidase N) as potential new medications in the management of pain and opioid addiction.
Roques
B P
BP
Département de Pharmacochimie Moléculaire et Structurale, U266 INSERM, Université René Descartes, Paris, France.
Noble
F
F
D000595:Amino Acid Sequence; D000818:Animals; D018826:CD13 Antigens / Q000187:drug effects* / Q000494:pharmacology*; D004745:Enkephalins / Q000187:drug effects / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008969:Molecular Sequence Data; D015260:Neprilysin / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*
D004745:Enkephalins; D004791:Enzyme Inhibitors; D018826:CD13 Antigens; D015260:Neprilysin