Mitochondrial encephalomyopathies presenting with features of autonomic and visceral dysfunction.
Three children are reported with mitochondrial encephalomyopathy who presented with autonomic dysfunction. Autonomic dysfunction included gastrointestinal dysmotility, apnea, cardiac arrhythmias, decreased lacrimation, supersensitivity to metacholine, altered sweating, and postural hypotension. These patients illustrate that in some mitochondrial encephalomyopathies autonomic features may be prominent and can mimic the clinical features associated with hereditary sensory and autonomic neuropathies.
Zelnik
N
N
Department of Neurology, New York University School of Medicine, New York, USA.
Axelrod
F B
FB
Leshinsky
E
E
Griebel
M L
ML
Kolodny
E H
EH
D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008928:Mitochondria / Q000201:enzymology; D017237:Mitochondrial Encephalomyopathies / Q000175:diagnosis* / Q000201:enzymology / Q000503:physiopathology; D014781:Viscera / Q000503:physiopathology