[Expression of c-fos mRNA induced by pressure overload in the left ventricle].
In the present study the effect of pressure overload on the expression of protooncogene c-fos in the left ventricle was investigated in rats with abdominal aorta constriction. It was found that a remarkable expression of c-fos was induced by pressure overload and the expression was greatly attenuated by angiotensin converting enzyme inhibitor captopril. In the pressure overload group the angiotensinogen mRNA level was found increased. The above results suggest that angiotensin II is involved in the expression of c-fos due to pressure overload.
Tan
D D
DD
Laboratory of Receptor, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Zhong
C N
CN
Chen
W H
WH
Pan
J Y
JY
Hu
B R
BR
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D001794:Blood Pressure; D002216:Captopril / Q000494:pharmacology; D015870:Gene Expression; D016762:Genes, fos; D006352:Heart Ventricles / Q000378:metabolism; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000806:Angiotensin-Converting Enzyme Inhibitors; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D000808:Angiotensinogen; D002216:Captopril