Carbohydrate metabolism and its regulatory hormones in anorexia nervosa.
Findings of studies of carbohydrate metabolism in anorexia nervosa are reviewed. Topics covered included fasting blood sugar concentrations; serum insulin concentrations, insulin receptor binding activity, insulin sensitivity, and insulin resistance; plasma ketone bodies and free fatty acids; glucose tolerance tests; growth hormone, cortisol, intestinal hormones, and norepinephrine. Metabolic changes reported in anorexia nervosa are similar to those found in human and animal studies of states of caloric and carbohydrate restriction. Restoration of normal body weight is associated with normalization of virtually all measures. It is concluded that published studies offer no conclusive evidence for a syndrome-specific impairment in carbohydrate metabolism in anorexia nervosa.
Casper
R C
RC
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA 94305-5546, USA.
D000818:Animals; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005508:Food Deprivation / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000097:blood; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D007657:Ketone Bodies / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D012016:Reference Values; D015430:Weight Gain / Q000502:physiology
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified; D005768:Gastrointestinal Hormones; D006728:Hormones; D007328:Insulin; D007657:Ketone Bodies; D013006:Growth Hormone; D006854:Hydrocortisone; D009638:Norepinephrine