CBFB/MYH11 fusion transcripts in a case of acute myelogenous leukemia (M1) with partial deletion of the long arm of chromosome 16.
Pericentric inversion of chromosome 16 [inv(16)(p13q22)] is seen in patients with acute myelomonocytic leukemia with bone marrow eosinophilia. This inversion juxtaposes the MYH11 gene on p13 and the CBFB gene on q22, resulting in the formation of a chimeric mRNA transcript. We describe a patient with acute myelogenous leukemia (M1), with del(16)(q22), who expressed the chimeric transcript. Reverse transcriptase polymerase chain reaction and the sequencing of its product showed fusion of 5'CBFB at position 495 to 3'MYH11 at position 1201. To our knowledge, this is the first report of an AML (M1) case with del(16) and CBFB/MYH11 rearrangement.
Usuki
K
K
Division of Hematology, Kanto Teishin Hospital, Tokyo.
Nakatsu
M
M
Kitazume
K
K
Endo
M
M
Osawa
M
M
Iki
S
S
Arai
M
M
Urabe
A
A
D000595:Amino Acid Sequence; D001483:Base Sequence; D001855:Bone Marrow Diseases / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics; D004802:Eosinophilia / Q000235:genetics / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D016133:Polymerase Chain Reaction
C095514:CBFbeta-MYH11 fusion protein; D004273:DNA, Neoplasm; D015514:Oncogene Proteins, Fusion