[Effect of antiserum against dynorphin A administered intrathecally on spinal cord injury (SCI) of rats and its significance].
The antagonistic effects of antisera against dynorphin A, beta-endorphin, and leu-enkephailin administered intrathecally on secondary SCI were observed and compared after moderate SCI using principle of antigen-antibody neutralization reaction. The protective effect of antiserum against dynorphin A was most prominent on secondary SCI and the effect was more prominent when administered at 24 hours following SCI than when administered at 0 hour four hours, one week or two weeks following SCI. That suggests increase of dynorphin A level in spinal cord tissue may play an active role in the early stage, but its harmful effect on secondary SCI will be more and more prominent after accumulation of excessive dynorphin A.
Li
M
M
Department of Orthopedics, Changhai Hospital, Shanghai.
Hong
X
X
Wu
Y
Y
D000818:Animals; D004399:Dynorphins / Q000276:immunology*; D004723:Endorphins / Q000276:immunology; D004743:Enkephalin, Leucine / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology*; D007116:Immunization, Passive; D007278:Injections, Spinal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009500:Neutralization Tests; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000473:pathology / Q000628:therapy*
D004723:Endorphins; D007106:Immune Sera; D010446:Peptide Fragments; D004743:Enkephalin, Leucine; C026843:dynorphin (1-13); D004399:Dynorphins