Inflammation in EAE: role of chemokine/cytokine expression by resident and infiltrating cells.
Experimental allergic encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS) which has many clinical and pathological features in common with multiple sclerosis (MS). Comparison of the histopathology of EAE and MS reveals a close similarity suggesting that these two diseases share common pathogenetic mechanisms. Immunologic processes are widely accepted to contribute to the initiation and continuation of the diseases and recent studies have indicated that microglia, astrocytes and the infiltrating immune cells have separate roles in the pathogenesis of the MS lesion. The role of cytokines as important regulatory elements in these immune processes has been well established in EAE and the presence of cytokines in cells at the edge of MS lesions has also been observed. However, the role of chemokines in the initial inflammatory process as well as in the unique demyelinating event associated with MS and EAE has only recently been examined. A few studies have detected the transient presence of selected chemokines at the earliest sign of leukocyte infiltration of CNS tissue and have suggested astrocytes as their cellular source. Based on these studies, chemokines have been postulated as a promising target for future therapy of CNS inflammation. This review summarized the events that occur during the inflammatory process in EAE and discusses the roles of cytokine and chemokine expression by the resident and infiltrating cells participating in the process.
Eng
L F
LF
Department of Pathology, Veteran Affairs Palo Alto Health Care System, CA 94304, USA.
Ghirnikar
R S
RS
Lee
Y L
YL
D000818:Animals; D001253:Astrocytes / Q000276:immunology*; D001483:Base Sequence; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D015870:Gene Expression; D006133:Growth Substances / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D017628:Microglia / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D009836:Oligodendroglia / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D018925:Chemokines; D016207:Cytokines; D006133:Growth Substances; D012333:RNA, Messenger