title: Immunoglobulin G galactosylation deficiency determined by isoelectric focusing and lectin affinoblotting in differential diagnosis of rheumatoid arthritis.
abstract: IgG galactosylation deficiency in patients with rheumatoid arthritis (RA) can be detected by isoelectric focusing (IEF)/lectin affinoblotting. We analyzed IgG glycosylation in patients with early arthritis (n = 50) and healthy controls in order to determine the clinical value of this parameter in differential diagnosis of RA. A significant correlation between the IgG galactosylation defect at disease onset and the diagnosis of RA during the follow-up was observed. Involvement of other clinical parameters (erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor) did not improve the predictive value of IgG galactosylation changes.
authors: Department of Rheumatology, Leipzig University, Germany.
authors: K
authors: K
authors: Kötz
authors: M
authors: M
authors: Hänsler
authors: H
authors: H
authors: Sauer
authors: S
authors: S
authors: Kaltenhäuser
authors: H
authors: H
authors: Häntzschel
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005690:Galactose / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007525:Isoelectric Focusing / Q000379:methods*; D037102:Lectins
chemical_list: D007074:Immunoglobulin G; D037102:Lectins; D005690:Galactose