title: Histological and electron-microscopic observations on the mucosa of pediculate gastric wall graft transplanted to the intestines in Wistar rats.
abstract: OBJECTIVE
  To study the machanism of the development of intestinal metaplasia through the transplantation of a flap of gastric wall with vascular pedicle to the intestines.
  
  
  METHODS
  The pedicled gastric wall flaps of Wistar rats were transplanted to their duodenum, jejunum and colon respectively. After the operation the rats were killed at the 3th, 6th, 9th and 12th month respectively, and histological change of the gastric grafts was observed with optical and electron microscopy.
  
  
  RESULTS
  Intestinal metaplasia was found in all the gastric grafts transplanted to the intestines and the alkaline phosphatase positive intestinal metaplasia was seen in the gastric graft mucosa transplanted to the duodenum and jejunum.
  
  
  CONCLUSIONS
  The formation of intestinal metaplasia in the gastric mucosa may be related to a change of the microenvironment around the tissues, and gastric mucosa may differentiate into intestinal mucosa by the increase of pH value. The possible mechanism of the development of intestinal metaplasia was discussed.
authors: Department of Gastroenterology, Air Force General Hospital, Beijing.
authors: C
authors: C
authors: Li
authors: W
authors: W
authors: Liu
authors: D
authors: D
authors: Fang
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D005744:Gastric Acid; D005753:Gastric Mucosa / Q000473:pathology* / Q000648:ultrastructure; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000601:surgery*; D008297:Male; D008679:Metaplasia; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach; D013524:Surgical Flaps / Q000379:methods