title: Adolescent disc protrusions. A long-term follow-up of surgery compared to chymopapain.
abstract: METHODS
  This study compared chymopapain with primary surgery in the treatment of 60 radiologically proven adolescent lumbar disc protrusions and symptoms of low back pain and sciatica; the failures of intradiscal therapy were treated by surgical discectomy.
  
  
  OBJECTIVE
  To establish whether chymopapain is as good as primary surgery in treating adolescents with proven lumbar disc protrusions.
  
  
  BACKGROUND
  Symptomatic lumbar disc protrusions are rare in white adolescents; the reported incidence varies from 0.8% to 3.2% of all lumbar disc protrusions. This is the largest study with long-term follow-up in the world literature.
  
  
  METHODS
  Forty-two patients between the ages of 13 and 19 years with proven lumbar disc protrusions were initially treated with chymopapain; the failures of intradiscal therapy were treated by surgical discectomy. Eighteen patients were treated with surgical discectomy. After initial review at 1, 3, 6, and 12 months, the patients were assessed using a postal questionnaire and telephone interview at a minimum of 5 years' follow-up (means: 8.5 years for chymopapain group, 7.2 years for surgery group).
  
  
  RESULTS
  Full replies were received from 16 of 18 (89%) in the surgery group and 42 of 42 (100%) in the chymopapain group. The long-term outcome is classed as good or excellent in 81% of the surgical group and 64% in the chymopapain group. If chymopapain is used as a first-line treatment, with surgery reserved for the failures, the long-term outcome is good or excellent in 82%. The chymopapain group had a shorter hospital stay. The surgical group were more likely to be unemployed and were less able to perform manual work and less able to engage in sporting activity.
  
  
  CONCLUSIONS
  Back pain, radicular pain, and tension signs are common, but neurologic signs are less frequent in this age group. Long-term results of surgery are no better than the results of first-line chymopapain treatment with surgery being reserved for the failures. In 60% to 70% of patients, the morbidity, cost, and hospital stay were lessened. The patient is more likely to be in satisfactory employment after chemonucleolysis than after primary surgery.
authors: Harlow Wood Orthopaedic Hospital, Mansfield, United Kingdom.
authors: N
authors: N
authors: Bradbury
authors: L F
authors: LF
authors: Wilson
authors: R C
authors: RC
authors: Mulholland
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D001416:Back Pain / Q000503:physiopathology; D002917:Chymopapain / Q000627:therapeutic use*; D004185:Disability Evaluation; D004651:Employment; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D007902:Length of Stay; D008297:Male; D010146:Pain / Q000503:physiopathology; D010147:Pain Measurement; D016896:Treatment Outcome
chemical_list: D002917:Chymopapain