[Fusaria infection in patients with neutropenia: apropos of 3 cases].
The authors report three cases of fusarial infection in neutropenic patients with hematologic malignancies. The first patient was affected by a cutaneous extensive fusariosis. The second patient developed a fusarial lung infection during a multiple organ failure following allogenic bone marrow transplantation. The third patient who presented with refractory acute myelogenous leukemia, developed fusarial skin lesions, and died from pulmonary failure. The treatment of fusarial infection is disappointing and requires amphotericin B, in association with hematopoietic growth factors. The role of new agents, or combination chemotherapy remains to be determinated. The recovery of adequate neutrophil levels is the most important factor in the resolution of fusarial infection.
Chevalet
P
P
Service d'hématologie, CHU de Nantes, France.
Tiab
M
M
Miegeville
M
M
Milpied
N
N
Harousseau
J L
JL
Moreau
P
P
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003881:Dermatomycoses / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005670:Fusarium; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*
D000935:Antifungal Agents; D000666:Amphotericin B
Infection fusariale chez le neutropénique: à propos de trois observations.