The inhibition of vitamin K3 on rabbit fibroblast proliferation in vitro.
Vitamin K3 that is commonly used to treat hemorrhagic diseases can inhibit human lymphatic neoplasms in vitro. This study was undertaken to investigate the effects of vitamin K3 on rabbit conjunctival fibroblast proliferation in cell culture. Vitamin K3 was added to cultured rabbit conjunctival fibroblasts. Remarkable inhibition was observed at a concentration of 4 mg/l. Because of its lower toxicity, vitamin K3 may prove to be of significant value in the treatment of intraocular proliferative disorders.
Liu
X H
XH
Department of Ophthalmology, Henan Medical University, Zhengzhou, China.
Song
X W
XW
Xu
Y
Y
Zhang
C
C
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003228:Conjunctiva / Q000166:cytology* / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D006490:Hemostatics / Q000494:pharmacology*; D011817:Rabbits; D014812:Vitamin K / Q000494:pharmacology*
D006490:Hemostatics; D014812:Vitamin K