[Effect of inhaled corticosteroids on serum eosinophil cationic protein and sIL-2R levels in asthmatics pulmonary hypertension].
To study the influence of corticosteroid and beta 2-agonist on eosinophil and T lymphocyte functioning state in the asthmatics, we measured the serum ECP sIL-2R levels and airway reactivity before and after 6-week treatment with beclometasone and terbutalin. The result revealed that after inhalation of steroid, the serum ECP sIL-2R levels decreased, whereas the lung function improved and MCH-PC20 values increased. It suggested that steroid could inhibit activation of eosinophil and T lymphocyte as well as show the effect of anti-inflammation and reducing AHR.
Wang
H
H
Department of Respiratory Disease, Xijing Hospital, 4th Military Medical University, Xian.
Sun
B
B
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D001507:Beclomethasone / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism*; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012129:Respiratory Function Tests; D012260:Ribonucleases; D013726:Terbutaline / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D018927:Anti-Asthmatic Agents; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D015375:Receptors, Interleukin-2; D012260:Ribonucleases; D001507:Beclomethasone; D013726:Terbutaline