Replication of hepatitis C virus.
The mode of replication of the hepatitis C virus (HCV) remains poorly understood. Attempts to produce a tissue culture model containing replicating HCV have been largely unsuccessful. Recent studies on sera from patients chronically infected with HCV have shown that viral particles may be found in high- or low-density fractions. High-density fractions contain non-infectious virions whilst infectious particles can be derived from low-density material. Using appropriate infectious fractions we have successfully infected a number of human cell lines allowing studies of HCV replication to be initiated.
Yoshikura
H
H
Department of Bacteriology, Faculty of Medicine, University of Tokyo, Japan.
Hijikata
M
M
Nakajima
N
N
Shimizu
Y K
YK
D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D002460:Cell Line; D002461:Cell Line, Transformed; D016174:Hepacivirus / Q000737:chemistry / Q000254:growth & development* / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology; D006790:Host-Parasite Interactions; D006801:Humans; D008099:Liver / Q000166:cytology; D002679:Pan troglodytes; D013601:T-Lymphocytes / Q000821:virology; D014779:Virus Replication / Q000502:physiology*