Effect of the CCKA antagonist devazepide on eating stimulated by raphe injection of 8-OH-DPAT.
Several recent studies have suggested that feeding suppression is mediated jointly by enhanced neurotransmission of cholecystokinin (CCK) and serotonergic (5-HT) systems. In the present study the CCKA receptor antagonist devazepide (50-200 micrograms kg-1, s.c.) was found reliably to potentiate the feeding response elicited by dorsal or median raphe injection of the 5-HT1A agonist 8-OH-DPAT (0.2-0.8 nmol). This effect was evident following co-administration of both feeding threshold and subthreshold doses of either compound, suggesting that the simultaneous suppression of CCK and 5-HT function may interact as joint effectors of overeating.
Currie
P J
PJ
Department of Psychology, Wayne State University, Detroit, MI 48202, USA.
Coscina
D V
DV
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D020109:Devazepide; D004435:Eating / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology*; D007267:Injections; D008297:Male; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D015203:Reproducibility of Results; D013268:Stimulation, Chemical
D001570:Benzodiazepinones; D006727:Hormone Antagonists; D011949:Receptors, Cholecystokinin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D020109:Devazepide