Antibodies directed to restricted sequences of the c-Erb A alpha hinge domain interfere with hormone or DNA binding to recombinant alpha-type triiodothyronine receptor (c-Erb A alpha1) and detect structural changes.
Daadi
M
M
INSERM Unite 38, Biochimie Medicale, Faculte de Medecine, Marseille, France.
Planells
R
R
Lenoir
C
C
Bonne
J
J
Giorgilli
G
G
Macchia
E
E
Torresani
J
J
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D008969:Molecular Sequence Data; D011817:Rabbits; D051381:Rats; D011988:Receptors, Thyroid Hormone / Q000737:chemistry / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D014284:Triiodothyronine / Q000378:metabolism*
D000906:Antibodies; D011988:Receptors, Thyroid Hormone; D011994:Recombinant Proteins; D014284:Triiodothyronine; D004247:DNA