Serum lipoprotein-a levels and glyco-metabolic control in insulin and non-insulin dependent diabetes mellitus.
OBJECTIVE
Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established.


METHODS
In our study Lp(a) was measured in a large group of diabetiee (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively.


RESULTS
Statistically significant differences between Lp(a) levels in IDDM and NIDDM-and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM.


CONCLUSIONS
These results suggest that the level of Lp(a) in serum is not influenced by diabetes mellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.
Westerhuis
L W
LW
Department of Clinical Chemistry, Ziekenhuis De Wever & Gregorius, Heerien The Netherlands.
Venekamp
W J
WJ
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000097:blood / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000097:blood / Q000378:metabolism; D005260:Female; D019270:Fructosamine / Q000097:blood / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged
D006454:Hemoglobins; D017270:Lipoprotein(a); D019270:Fructosamine