[Retinal vein occlusion and resistance to activated protein C].
BACKGROUND
A new abnormality in the coagulation system, the resistance to activated protein C, has appeared among the numerous hereditary modifications which predispose patients to deep-vein thrombosis. The molecular abnormality responsible for the resistance to activated protein C is due to a mutation of an amino acid in the 506 position (Arg-->Gln) at the level of the factor V, designated under the name of factor V Leiden.


METHODS
The authors wished to search for this alteration of the haemostasis in 106 patients with retinal venous occlusion hospitalized in Centre Hospitalier National d'Ophthalmologie des Quinze-Vingts (Paris).


RESULTS
In our study of 106 patients presenting a retinal venous occlusion, the resistance to activated protein C was the most frequent coagulation abnormality found (4.71%), when compared with the other deficits of the inhibitors of the clotting system: protein S (2.80%), antithrombin III (0.94%) et protein C (0%).


CONCLUSIONS
The test of resistance to activated protein C should be recommanded in cases of retinal venous occlusion, particularly in the search for a cause of thrombosis in young patients or in recurrent thrombosis.
Scat
Y
Y
Service de Biologie Médicale, Centre Hospitalier National d'Ophthalmologie des Quinze-Vingts, Paris.
Morin
Y
Y
Morel
C
C
Haut
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D004351:Drug Resistance; D005165:Factor V / Q000235:genetics; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011486:Protein C / Q000378:metabolism / Q000502:physiology*; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology* / Q000235:genetics
D001779:Blood Coagulation Factors; D011486:Protein C; D005165:Factor V
Occlusion veineuse de la rétine et résistance à la protéine C activée.