Minocycline-induced hyperpigmentation in leprosy.
A 36-year-old man was treated with dapsone, rifampicin and clofazimine for borderline lepromatous leprosy. After 9 months, his leprosy plaques became progressively more red and after 23 months, the clofazimine was stopped and he was given minocycline instead. Six weeks later, he developed blue-black pigmentation in his leprosy lesions. The histology was consistent with minocycline-induced hyperpigmentation. This is the first report of minocycline-induced pigmentation in leprosy. We suggest it is important to consider this side-effect before the administration of minocycline in leprosy, particularly if it is prescribed in place of clofazimine.
Fleming
C J
CJ
Department of Dermatology, Royal Prince Alfred Hospital, New South Wales, Australia.
Hunt
M J
MJ
Salisbury
E L
EL
McCarthy
S W
SW
Barnetson
R S
RS
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D015440:Leprosy, Lepromatous / Q000188:drug therapy*; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D008911:Minocycline