[Increased production of nitric oxide in the immediate and late asthmatic responses in models of guinea pig experimental asthma].
Nitric oxide is produced in mammalian airways by constitutive and inducible nitric oxide synthase, and endogenous nitric oxide can be detected as exhaled gas. Patients with asthma have large numbers of airway epithelial cells and inflammatory cells that contain nitric oxide synthase, and nitric oxide levels in exhaled air are high during immediate asthmatic responses. To examine the dynamics of nitric oxide synthase in the tracheas of guinea pigs, cumulative dose-response studies of 5-HT were done on tracheal strips, in the presence or absence of arginine and its analogues. This assay indicated that relative the activity of nitric oxide synthase was greater 6 hr after the challenge than immediately after, which suggests that nitric oxide is involved in the pathogenesis of bronchial asthma attacks.
Uchida
Y
Y
Department of Pulmonary Medicine, University of Tsukuba.
Endo
T
T
Iijima
H
H
Nomura
A
A
Ninomiya
H
H
Noguchi
Y
Y
Dunn
D
D
Xiang
A
A
Saitoh
T
T
Hashimoto
K
K
D000818:Animals; D001249:Asthma / Q000378:metabolism*; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed / Q000378:metabolism; D006969:Hypersensitivity, Immediate / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000378:metabolism
D009569:Nitric Oxide; D012701:Serotonin; D019001:Nitric Oxide Synthase