[Relationship between c-erbB-2 oncoprotein expression and prognosis in salivary gland malignant pleomorphic adenoma].
A monoclonal antibody AB-3 has been used immunohistochemically in a retrospective study of formalin-fixed paraffin embedded tissues of the salivary gland malignant pleomorphic adenomas (MPA). Positive staining was found in 25/60 (41.67%) of MPA. c-erbB-2 oncoprotein expression of the postoperative recurrent MPA group was higher than that of non-recurrent MPA group (P < 0.05). The postoperative 5-year survival rate of MPA with c-erbB-2 expression was considerably lower than that of without expression (P < 0.01). This observation indicates that c-erbB-2 oncoprotein expression may be an useful prognostic indicator in MPA.
Yan
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Y
Department of Stomatology, Tangdu Hospital, Fourth Military Medical University, Xian.
Guo
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Q
Nan
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P
D008949:Adenoma, Pleomorphic / Q000235:genetics* / Q000401:mortality; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D018734:Genes, erbB-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics / Q000401:mortality; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000401:mortality; D013365:Submandibular Gland Neoplasms / Q000235:genetics / Q000401:mortality; D015996:Survival Rate
D018719:Erb-b2 Receptor Tyrosine Kinases