title: Drosophila differentiation genes instrumental in tumor suppression.
abstract: Tumor suppressor genes of Drosophila are developmental genes which, in the homozygously mutated state, induce in one step malignant or benign neoplastic transformation of specific cell types. They act early in development and by this set the stage for cell specific differentiation of imaginal discs, adult optic neuroblasts, blood and gonial cells. The structure, expression and possible function of the following four tumor suppressor genes are discussed: tumorous imaginal disc, lethal (3) malignant brain tumor, lethal (3) malignant blood neoplasm-1 and benign (2) gonial cell neoplasm.
authors: Institut für Genetik, Johannes Gutenberg-Universität, Mainz, Germany.
authors: E
authors: E
authors: Gateff
authors: U
authors: U
authors: Kurzik-Dumke
authors: J
authors: J
authors: Wismar
authors: T
authors: T
authors: Löffler
authors: N
authors: N
authors: Habtemichael
authors: L
authors: L
authors: Konrad
authors: S
authors: S
authors: Dreschers
authors: S
authors: S
authors: Kaiser
authors: U
authors: U
authors: Protin
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D005260:Female; D017344:Genes, Insect; D016147:Genes, Tumor Suppressor; D050956:HSP40 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000235:genetics; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics; D005810:Multigene Family; D016335:Zinc Fingers / Q000235:genetics
chemical_list: D050956:HSP40 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones