[Study of immunobiological properties of specific immunomodulators of the adjuvant type in experimental tuberculosis].
CBA mice served as experimental tuberculosis model to study protective, immunomodulating and toxico-allergic properties of two drugs including cytoplasma and cell walls of BCG mycobacteria as well as of synthetic adjuvant polyoxidonium. Doses and schemes are presented developed for experimental tuberculosis treatment with cytoplasm and not causing toxico-allergic reactions in mice. The specific immunomodulator of cytoplasm, polyoxidonium, proved effective therapeutic modality in experimental mouse tuberculosis.
Gorelova
L A
LA
Zemskova
Z S
ZS
Panasek
I A
IA
Nekrasov
A V
AV
Puchkova
N G
NG
Moroz
A M
AM
Romanova
R Iu
RIu
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D002473:Cell Wall / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009163:Mycobacterium bovis / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014373:Tuberculin / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000628:therapy*
D000276:Adjuvants, Immunologic; D014373:Tuberculin
Izuchenie immunobiologicheskikh svoĭstv spetsificheskikh immunomoduliatorov ad'iuvantnogo tipa pri éksperimental'nom tuberkuleze.