Solitary plasmacytoma of the spine: relationship of IGM to tumour progression and recurrence.
The authors report a retrospective study of 15 patients with solitary vertebral plasmacytoma. 15 patients were considered in this study on the basis of the following characteristics: 1) histologically confirmed plasmacytoma following surgical removal; 2) existence of a single vertebral lesion, documented by skeletal and MRI scan; 3) no signs, at diagnosis of disseminated disease by blood laboratory test, urine analysis, sternal puncture, iliac bone marrow biopsy, a total-body CT scan. The clinical course of the patients has been analysed on the basis of the following factors: age, sex, length of clinical history before diagnosis, site, presence/absence of the M component. The M component is an electrophoretically homogeneous immunoglobin. The most significant factors for predicting development of multiple myeloma proved to be the presence /absence of the M component at diagnosis and, to a lesser degree, the age of the patient. In the light of other reports too, it would seem that the presence of the M component at diagnosis is a reflection of aggressive biological and clinical tumour behaviour.
Cervoni
L
L
Department of Neurological Sciences, Neurosurgery, La Sapienza University of Rome, Italy.
Celli
P
P
Salvati
M
M
Tarantino
R
R
Fortuna
A
A
D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007796:Laminectomy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery; D010954:Plasmacytoma / Q000175:diagnosis* / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery; D014057:Tomography, X-Ray Computed
D007075:Immunoglobulin M