[A clinical-pathological study on hypoxic ischemic encephalopathy in 124 cases of perinates].
OBJECTIVE
To explore the morphological feature, its pathogenesis and clinical significance of hypoxic-ischemic encephalopathy (HIE) through pathological examinations.


METHODS
In addition to the routine pathologic examination, the brain tissues, including frontal lobus, temporal lobus, occipital lobus, hippocampus, capsula interna, cerebellum and medullary bulb, were sectioned and examined respectively.


RESULTS
(1) 93.5% of cases had a history of direct or indirect asphyxia. (2) The main pathological alterations were edema, congestion, hyaline thrombosis, haemorrhage, degeneration and necrosis of nerve cells. Softening, calcification, cavity formation and fibrosis were also seen in some cases.


CONCLUSIONS
The study suggested that congestion and edema of cerebral tissue were essential changes for the pathogenesis of HIE. Hemorrhage and necrosis were common pathological alterations. Fibrosis and cavitation were changes of convalescence. It is of primary importance to treat asphyxia during perinatal period for the prevention of HIE.
Zhang
L
L
Capital Institute of Pediatrics, Beijing.
Lin
J
J
Cai
L
L
D001238:Asphyxia Neonatorum / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology*; D005260:Female; D005313:Fetal Death / Q000473:pathology; D005311:Fetal Hypoxia / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy