Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses.
Equine rhinoviruses (ERVs) are picornaviruses which cause a mild respiratory infection in horses. The illness resembles the common cold brought about by rhinoviruses in humans; however, the presence of a viraemia during ERV-1 infection, the occurrence of persistent infections and the physical properties are all more reminiscent of foot-and-mouth disease virus (FMDV). cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Nevertheless, the genomic architecture of both serotypes is most similar to that of FMDV. Indeed, a comparison of the derived protein sequences of ERV-1 shows that their identity is greatest to FMDV. In contrast, most ERV-2 proteins are more related to encephalomyocarditis virus (EMCV) proteins than they are to FMDV or ERV-1. These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV.
Wutz
G
G
Institute of Biochemistry, Medical Faculty, University of Vienna, Austria.
Auer
H
H
Nowotny
N
N
Grosse
B
B
Skern
T
T
Kuechler
E
E
D000595:Amino Acid Sequence; D000818:Animals; D005537:Aphthovirus / Q000145:classification / Q000235:genetics; D001483:Base Sequence; D002213:Capsid / Q000737:chemistry; D017943:Cardiovirus / Q000145:classification / Q000235:genetics; D002460:Cell Line; D004279:DNA, Viral; D016679:Genome, Viral; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D010849:Picornaviridae / Q000145:classification* / Q000235:genetics; D011817:Rabbits; D017386:Sequence Homology, Amino Acid; D012703:Serotyping; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D014764:Viral Proteins