title: Multiple anthelmintic resistance in Haemonchus contortus on a sheep farm in India.
abstract: Multiple resistance to benzimidazoles (fenbendazole, albendazole and mebendazole) in a strain of Haemonchus contortus in sheep was detected on a farm where fenbendazole resistance had already been identified. Following a faecal egg count reduction test, this was confirmed by both critical and controlled anthelmintic tests. Different groups of sheep infected naturally or given an experimental infection with the fenbendazole-resistant strain were treated with the recommended doses of various anthelmintics. Compared to the control group, percentage reductions in faecal egg counts of sheep treated with fenbendazole, albendazole, mebendazole, levamisole and morantel varied between 56% and 81% and worm counts between 71% and 86%. The results indicate the presence of multiple anthelmintic resistance in this strain of H. contortus on this farm. Sheep treated with ivermectin and closantel showed 100% reductions in faecal egg and worm counts, suggesting high efficacy of these drugs against the population of H. contortus on this farm.
authors: Department of Veterinary Parasitology, CCS Haryana Agricultural University, Hisar, India.
authors: C L
authors: CL
authors: Yadav
authors: R
authors: R
authors: Kumar
authors: R P
authors: RP
authors: Uppal
authors: S P
authors: SP
authors: Verma
mesh_terms: D015766:Albendazole / Q000627:therapeutic use / Q000633:toxicity; D000822:Animal Husbandry; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use* / Q000633:toxicity; D001562:Benzimidazoles / Q000627:therapeutic use* / Q000633:toxicity; D018432:Drug Resistance, Multiple; D005273:Fenbendazole / Q000627:therapeutic use / Q000633:toxicity; D006188:Haemonchiasis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects*; D007194:India; D007559:Ivermectin / Q000627:therapeutic use; D008463:Mebendazole / Q000627:therapeutic use / Q000633:toxicity; D010270:Parasite Egg Count; D012458:Salicylanilides / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D012458:Salicylanilides; D005273:Fenbendazole; D007559:Ivermectin; D008463:Mebendazole; C023342:closantel; D015766:Albendazole