The effect of rifampicin on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides.
Using the dynamic chequerboard technique, we confirmed that rifampicin produces a synergistic bactericidal effect when combined with amikacin or netilmicin. Adaptive resistance was suppressed when rifampicin was added to aminoglycoside after, but not during, first exposure to amikacin or netilmicin. The effect of rifampicin on adaptive resistance could account for the synergy between rifampicin and aminoglycosides.
Xiong
Y Q
YQ
Laboratoire d'Antibiologie Clinique et Expérimentale, Faculté de Médecine, Centre Hospitalier Universitaire, Nantes, France.
Caillon
J
J
Drugeon
H
H
Potel
G
G
Baron
D
D
D000222:Adaptation, Physiological; D000617:Aminoglycosides / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology*; D012293:Rifampin / Q000494:pharmacology*
D000617:Aminoglycosides; D000904:Antibiotics, Antitubercular; D012293:Rifampin