The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin.
Five extracts (n-hexane, chloroform, ethyl acetate, n-butanol and water) of Scutellaria rivularis Benth. were evaluated for their anti-inflammatory activity against carrageenan-induced paw edema in rats and compared with indomethacin. The result indicated that chloroform extract proved to be the most effective in all of the extracts. Consequently, three major components (baicalin, baicalein and wogonin) of the chloroform extract were further tested for their anti-inflammatory activity using the same model. It was found that baicalin exhibits the greatest inhibition activity against carrageenan-induced rat paw edema.
Lin
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Graduate Institute of Natural Products, Kaohsiung Medical College, Taiwan.
Shieh
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D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D008516:Medicine, Chinese Traditional; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar
D000890:Anti-Infective Agents; D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein; D002351:Carrageenan; C085514:wogonin