[The effect of antiseptic agents on the growth of mouse skin].
Using new born mouse skin slice culture, we studied the effects on certain antiseptic agents on the growth of epidermis, 0.015% approximately 1% chloromycin, 0.125 approximately 1% zinc sulfadiazine, 0.125% approximately 1.0% silver sulfadiazine markedly inhibited the expending rate of mouse skin. The higher the concentration of drugs, the higher is the inhibition rate. 10,000 U% gentamycin and 25,000U% polymyxin showed no adverse effects on skin expending rate. We conclude that during topical use of antiseptic agents (antibiotics or chemical compounds) in treatment of patients, the inhibitability of those agents on epidermis growth should be seriously considered.
Zhu
Z
Z
Burn Unit 304 Hospital, People's Liberation Army, Beijing.
Kong
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Q
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D046508:Culture Techniques; D005839:Gentamicins / Q000494:pharmacology; D051379:Mice; D011113:Polymyxins / Q000494:pharmacology; D012837:Silver Sulfadiazine / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000254:growth & development*
D000891:Anti-Infective Agents, Local; D005839:Gentamicins; D011113:Polymyxins; D002701:Chloramphenicol; D012837:Silver Sulfadiazine