title: Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk.
abstract: Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p < 0.02).
authors: Chalfont Centre for Epilepsy, National Hospital, United Kingdom.
authors: L M
authors: LM
authors: Li
authors: M
authors: M
authors: Russo
authors: M F
authors: MF
authors: O'Donoghue
authors: J S
authors: JS
authors: Duncan
authors: J W
authors: JW
authors: Sander
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014227:Triazines / Q000009:adverse effects*; D014635:Valproic Acid / Q000008:administration & dosage*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine