[Preparation of beta-1,3-glucan synthase and its application to the screening of antifungal antibiotics].
beta-1,3-glucan synthase was obtained as a particulate fraction from cell-free extracts prepared after mechanical breakage cells of Candida albicans. Some properties of the glucan synthase were investigated. Using it as a target for screening for novel antifungal compounds, we obtained strains whose products showed differential enzyme inhibition.
Zheng
D
D
State Key Laboratory of Microbial Resources, Academia Sinica, Beijing.
Zhang
J
J
Song
Y
Y
Song
D
D
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000302:isolation & purification*; D008565:Membrane Proteins; D029702:Schizosaccharomyces pombe Proteins
D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D008565:Membrane Proteins; D029702:Schizosaccharomyces pombe Proteins; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase