Dithiocarbamates inhibit IL-1-induced cartilage degradation in bovine articular cartilage explants.
Interleukin-1-stimulated cartilage degradation in bovine articular cartilage explants is effectively inhibited by several different dithiocarbamates with IC50's in the micromolar range.
Oleksyszyn
J
J
OsteoArthritis Sciences Inc., Cambridge, MA 02139, USA.
Augustine
A J
AJ
D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002417:Cattle; D006025:Glycosaminoglycans / Q000378:metabolism; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013859:Thiocarbamates / Q000494:pharmacology*
D006025:Glycosaminoglycans; D007375:Interleukin-1; D017382:Reactive Oxygen Species; D013859:Thiocarbamates; D008666:Metalloendopeptidases