title: Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2.
abstract: The influence of iron on the entry of Listeria monocytogenes into Caco-2 cells was studied. Iron availability was found to modify the surface hydrophobicity and protein profile of L. monocytogenes, with the result that cell invasion strongly increased upon bacterial growth in iron-rich medium. The enhanced invasive capability of iron-overloaded L. monocytogenes cells correlates to the higher-level expression of the inlAB virulence genes, which were positively iron regulated at the transcriptional level.
authors: Institute of Microbiology, University of Rome La Sapienza, Italy.
authors: M P
authors: MP
authors: Conte
authors: C
authors: C
authors: Longhi
authors: M
authors: M
authors: Polidoro
authors: G
authors: G
authors: Petrone
authors: V
authors: V
authors: Buonfiglio
authors: S
authors: S
authors: Di Santo
authors: E
authors: E
authors: Papi
authors: L
authors: L
authors: Seganti
authors: P
authors: P
authors: Visca
authors: P
authors: P
authors: Valenti
mesh_terms: D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D001427:Bacterial Toxins; D018938:Caco-2 Cells; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000235:genetics*; D006460:Hemolysin Proteins; D006461:Hemolysis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008089:Listeria monocytogenes / Q000737:chemistry / Q000235:genetics / Q000472:pathogenicity*; D008088:Listeriosis / Q000382:microbiology*; D012329:RNA, Bacterial / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012995:Solubility; D013499:Surface Properties; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D012329:RNA, Bacterial; D012333:RNA, Messenger; C069761:internalin protein, Bacteria; D007501:Iron; C038705:hlyA protein, Listeria monocytogenes