[Chemotherapy of metastatic endometrial carcinoma. Review of the literature].
Endometrial carcinoma is one of the most common gynaecological cancers in Western countries. About 75% of the patients present limited disease, confined to the uterus that can be cured by surgery. However, one third of the patients will need systemic treatment because of metastatic or relapsing disease. Hormonotherapy response rates are less than 20%. In monochemotherapy, the higher response rates are constantly observed with doxorubicin or cisplatinum (25-35%). Most commonly used combination are CAP (cyclophosphamide, doxorubicin, cisplatinum) or AP (doxorubicin, cisplatinum), giving 35 to 60% of objective responses. Recent results of large randomized trials have demonstrated marginal, if any, effect of cyclophosphamide and superiority of doxorubicin-cisplatinum combination compared to doxorubicin alone for response and survival. Chemotherapy as hormonotherapy remains palliative. Median response duration is 4 to 6 months and median overall survival duration is 7 to 10 months. Currently, hormonotherapy-chemotherapy combination have not been proved to be more effective than chemotherapy alone.
Pierga
J Y
JY
Departement de medecine oncologique, institut Curie, 26 rue d'Ulm, 75231 Paris Cedex 05, France.
Dieras
V
V
Paraiso
D
D
Pouillart
P
P
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010752:Phosphoramide Mustards / Q000008:administration & dosage; D045167:Progesterone Congeners / Q000627:therapeutic use*; D011379:Prognosis; D016019:Survival Analysis
D000970:Antineoplastic Agents; D010752:Phosphoramide Mustards; D045167:Progesterone Congeners; D004317:Doxorubicin; D002945:Cisplatin
Chemiothérapie des carcinomes de l'endomètre metastatiques: revue de la littérature.