[Structural-functional changes in erythrocyte membranes in bovine lympholeukemia].
The condition of lipid peroxidation and activity of enzymes of protective glutathione-dependent anti-oxidation system of erythrocytes: glutathione peroxidase (GSH-P) and glutathione reductase (GSH-R) in cows with leukosis has been studied. The decrease of the level of MDA and GSH-R activity was accompanied by GSH-P activation depending on the stage disease. The considerable lowering of Ca2+ transport to erythrocytes was shown on hematological stage of leucosis. The qualitative composition of membrane proteins does not change according to gel electrophoresis data. But the quantity of main cytoskeleton protein, spectrin, increases in the "white shadows" of erythrocytes in the animals with leucosis.
Riazantsev
V V
VV
Kovalenko
L V
LV
Belous
A M
AM
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002417:Cattle; D002463:Cell Membrane Permeability / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000097:blood*; D016583:Enzootic Bovine Leukosis / Q000097:blood*; D004910:Erythrocyte Membrane / Q000502:physiology / Q000648:ultrastructure*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D015227:Lipid Peroxidation / Q000502:physiology; D008315:Malondialdehyde / Q000097:blood; D012016:Reference Values
D000975:Antioxidants; D003598:Cytoskeletal Proteins; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase
Strukturno-funktsional'nye izmeneniia membran éritrotsitov pri limfoleĭkoze u korov.