[Gonadotropins stimulate the proliferation of human epithelial ovarian cancer cell].
OBJECTIVE
To observe the effect of FSH and LH on the proliferation of human epithelial ovarian cancer cell.


METHODS
Human epithelial ovarian cancer AO cells were incubated with follicle stimulating hormone (FSH) and luteinizing hormone (LH) (2U/L and 2.5U/L respectively). They were detected for proliferation by the use of the immunohistochemical technique and morphology.


RESULTS
The positive rate of proliferating cell nuclear antigen expressed in the cancer cell was increased significantly (p < 0.05) indicating its proliferation stimulating effect by FSH. The mitosis of cancer cells was increased by FSH and by LH (35%, 16% respectively).


CONCLUSIONS
It is suggested that FSH and LH can stimulate the proliferation of epithelial ovarian cancer cell, and they may play an important in the development of epithelial ovarian cancer.
Feng
Y
Y
Obstetrics Gynecology Hospital of Shanghai Medical University.
Zhang
X
X
Ge
B
B
D002455:Cell Division / Q000187:drug effects; D018284:Cystadenocarcinoma, Serous / Q000473:pathology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000494:pharmacology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D014407:Tumor Cells, Cultured
D018809:Proliferating Cell Nuclear Antigen; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone