title: [Contrast medium behavior of epithelial skin tumors and tumor-like changes in high resolution magnetic resonance tomography].
abstract: To evaluate the use of Gd-DTPA in imaging epithelial skin tumors and tumor-like lesions, 29 benign, 8 malignant and 4 semimalignant skin tumors were prospectively examined by high-resolution MRI at 1.5 Tesla using a 2.5-cm surface coil. For tumor assessment, transverse plain and contrast-enhanced scans (0.1 mmol Gd-DTPA/kg body mass) were performed (TR 500 ms, TE 25 ms, 3 acquisitions, 256 x 256 matrix, FOV 2.5 cm). Contrast enhancement was quantitively determined as the percent enhancement of signal intensity. Histologic findings were correlated using the Mann-Whitney-test (p < 0.05). Quality of contrast enhancement was independently assessed by three investigators, who mostly described inhomogeneous enhancement, regardless of histologic findings. Malignant tumors could not be differentiated from benign lesions by contrast enhancement. MRI using Gd-DTPA does not provide differentiation of skin tumor types.
authors: Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakultät, Humboldt-Universität zu Berlin.
authors: J
authors: J
authors: Mäurer
authors: D
authors: D
authors: Schlums
authors: G
authors: G
authors: Lissau
authors: W
authors: W
authors: Richter
authors: F D
authors: FD
authors: Knollmann
authors: R
authors: R
authors: Langer
authors: J
authors: J
authors: Bier
authors: R
authors: R
authors: Felix
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology; D011446:Prospective Studies; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA
vernacular_title: Kontrastmittelverhalten von epithelialen Hauttumoren und tumorartigen Veränderungen in der hochauflösenden Kernspintomographie.