title: Headache in ambulatory HIV-1-infected men enrolled in a longitudinal study.
abstract: OBJECTIVE
  To report headache (HA) data collected from subjects in a longitudinal study of human immunodeficiency virus (HIV)-1 and the central nervous system (CNS) DESIGN/METHODS: Baseline data from 229 ambulatory HIV-seropositive (HIV+) and 53 seronegative control subjects were analyzed. Subjects were classified by the presence or absence of HIV-1-associated HAs and HIV-1-associated systemic and neurologic disease. Subjects were followed longitudinally for up to 5 years.
  
  
  RESULTS
  In the cross-sectional analysis, significant associations were observed between HIV-1-associated HAs and (1) anxiety and depression, and (2) a history of drug use, psychiatric disease, and non-HIV-1 neurologic disease. No significant differences in laboratory values were found between subjects with HIV-1-associated HA compared with those without HA. When HIV+ subjects were followed longitudinally, onset of new HIV-1-associated systemic or neurologic disease over 1 year was not predicted by the presence of an HIV-1-associated HA at baseline.
  
  
  CONCLUSIONS
  Headaches are common in HIV+ persons at all stages of disease. Presence of HIV-1-associated HAs at baseline were not associated with neurologic disease progression over 1 year of follow-up in our sample.
authors: Neurology and Research Services, DVA West Los Angeles Medical Center, CA 90073, USA.
authors: E J
authors: EJ
authors: Singer
authors: J
authors: J
authors: Kim
authors: B
authors: B
authors: Fahy-Chandon
authors: A
authors: A
authors: Datt
authors: W W
authors: WW
authors: Tourtellotte
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006261:Headache / Q000150:complications*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged