The effect of glutaraldehyde adulteration of urine specimens on syva EMIT II drugs-of-abuse assays.
The effect of glutaraldehyde (the active component of "UrinAid") on Syva EMIT II drugs-of-abuse screening assays was studied. It was found that, dependent on the assay involved, concentrations of between 0.75 and 2.00% (v/v) of glutaraldehyde in urine could give rise to false-negative screening results. A simple method for identifying urine specimens that have been adulterated with glutaraldehyde, based on final absorbance rate readings (dA/min), is proposed.
George
S
S
Regional Laboratory for Toxicology, City Hospital NHS Trust, Birmingham, UK.
Braithwaite
R A
RA
D000042:Absorption; D002138:Calibration; D003362:Cost-Benefit Analysis; D017248:Enzyme Multiplied Immunoassay Technique; D005188:False Negative Reactions; D005976:Glutaral / Q000737:chemistry* / Q000652:urine; D006801:Humans; D013287:Illicit Drugs / Q000652:urine*; D015203:Reproducibility of Results
D013287:Illicit Drugs; D005976:Glutaral