Inherited muscular disorder in mutant Japanese quail (Coturnix coturnix japonica): an ultrastructural study.
Ultrastructural study of muscles taken from a mutant (LWC) strain of Japanese quail with myotonia showed type 2 fibre atrophy, ring fibre formation, sarcoplasmic masses, and "moth-eaten" fibres. In these abnormal fibres, the most characteristic feature was the loss of interconnection among the myofibrils, mitochondria, and T tubules. Apparently normal muscle fibres often showed mild changes, such as proliferation of T tubules and enlarged sarcoplasmic areas with increased glycogen granules and ribosomes at the periphery of the fibres. The study suggested that one possible cause of these ultrastructural changes was a defect in cytoskeleton of muscle cells, especially in intermediate filaments.
Tanaka
S
S
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Braga
I S
IS
Kimura
T
T
Ochiai
K
K
Itakura
C
C
Mizutani
M
M
D000818:Animals; D001284:Atrophy; D003370:Coturnix / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007382:Intermediate Filaments / Q000648:ultrastructure; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure*; D009137:Muscular Dystrophy, Animal / Q000473:pathology; D009223:Myotonic Dystrophy / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000235:genetics / Q000473:pathology*; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure; D013045:Species Specificity