title: Effects of moderate hypothermia on baroreflex and pulmonary chemoreflex heart rate response in decerebrate ferrets.
abstract: The effects on the baroreceptor reflexes and pulmonary reflexes of moderate immersion hypothermia (core temperature, 30.2 +/- 0.07 degrees C) have been investigated in the decerebrate ferret. Baroreflex sensitivity was estimated from the relationship between change in cardiac interval and change in systolic blood pressure following i.v. bolus injection of phenylephrine. The responses to phenylephrine in ferrets were best fitted by two linear slopes with an initial shallow slope, a, followed by a steeper slope, b. The slope or sensitivity of b was increased significantly by moderate cooling (n = 6 animals, 36 responses, P < 0.05). Pulmonary J-receptor reflex sensitivity was assessed by i.v. injection of phenylbiguanide (PBG), which evokes a dose-dependent bradycardia. The bradycardic response was unaltered by the hypothermia (n = 6 animals, 88 responses). Electrical stimulation of the right peripheral vagal nerve was employed to assess effects on the efferent components of the reflexes. The bradycardia, in response to stimulation, was significantly increased by moderate cooling at all stimulation frequencies (n = 8 animals, 88 responses, P < 0.001). Thus the results suggested that baroreceptor heart rate reflex sensitivity was enhanced by the moderate hypothermia. At least one component of the enhanced baroreflex response may be the result of changes in the efferent pathway of the reflex response. However, the absence of effect of PBG may indicate a differential afferent and efferent organization of pulmonary J-receptors compared with baroreceptors.
authors: Department of Biomedical Sciences, Marischal College, University of Aberdeen, UK.
authors: F
authors: F
authors: Zheng
authors: C
authors: C
authors: Kidd
authors: F
authors: F
authors: Bowser-Riley
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D001645:Biguanides / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D003655:Decerebrate State; D004558:Electric Stimulation; D005260:Female; D005289:Ferrets; D006339:Heart Rate / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007035:Hypothermia / Q000503:physiopathology*; D008168:Lung / Q000294:innervation*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D001645:Biguanides; D007004:Hypoglycemic Agents; D017366:Serotonin Receptor Agonists; D010656:Phenylephrine; C008846:phenyl biguanide