[Role of adhesion molecules in the development of acute lung injury].
Polymorphonuclear neutrophils (PMN) play a central role in the development of acute lung injury. Sequestered and activated PMN in the lungs produce inflammatory mediators such as reactive oxygen intermediates and proteases, which increase endothelial permeability. The interaction of PMN and endothelial cells mediated by adhesion molecules is a crucial step in PMN-mediated injury. These molecules mediate the adhesion of PMN to endothelial cells, and the migration of PMN into the interstitium. In these steps, PMN are also activated by adhesion molecules. We examined the role of adhesion molecules in the PMN-mediated increase in endothelial permeability in vivo with a rat model of lung injury, and in vivo with an assay of endothelial monolayer permeability.
Ishii
Y
Y
Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.
D000208:Acute Disease; D000818:Animals; D002199:Capillary Permeability; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000166:cytology; D008171:Lung Diseases / Q000209:etiology* / Q000628:therapy; D009504:Neutrophils; D051381:Rats
D015815:Cell Adhesion Molecules