The role of beta 2-glycoprotein I in the antiphospholipid syndrome.
Antiphospholipid antibodies were originally thought to bind negatively-charged (anionic) phospholipids. Current evidence suggest that the target antigen is considerably more complex and includes beta 2-glycoprotein I, a phospholipid-binding plasma protein. Our understanding of the pathophysiology of the antiphospholipid syndrome has increased exponentially with a number of studies into the interactions of antiphospholipid antibodies and beta 2-glycoprotein I.
Krilis
S A
SA
Department of Immunology, Allergy and Infectious Disease, St George Hospital University of NSW, Australia.
Sheng
Y H
YH
Kandiah
D A
DA
D000595:Amino Acid Sequence; D017153:Antibodies, Anticardiolipin / Q000737:chemistry / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000737:chemistry / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000097:blood*; D001053:Apolipoproteins / Q000097:blood; D001665:Binding Sites; D006023:Glycoproteins / Q000097:blood* / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000097:blood; D017434:Protein Structure, Tertiary; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D001053:Apolipoproteins; D006023:Glycoproteins; D010743:Phospholipids; D053482:beta 2-Glycoprotein I