Leukocyte-reduced blood components: patient benefits and practical applications.
OBJECTIVE
To review the various types of filters used for red blood cell and platelet transfusions and to explain the trend in the use of leukocyte removal filters, practical information about their use, considerations in the selection of a filtration method, and cost-effectiveness issues.


METHODS
Published articles, books, and the author's experience.


RESULTS
Leukocyte removal filters are used to reduce complications associated with transfused white blood cells that are contained in units of red blood cells and platelets. These complications include nonhemolytic febrile transfusion reactions (NHFTRs), alloimmunization and refractoriness to platelet transfusion, transfusion-transmitted cytomegalovirus (CMV), and immunomodulation. Leukocyte removal filters may be used at the bedside, in a hospital blood bank, or in a blood collection center. Factors that affect the flow rate of these filters include the variations in the blood component, the equipment used, and filter priming. Studies on the cost-effectiveness of using leukocyte-reduced blood components demonstrate savings based on the reduction of NHFTRs, reduction in the number of blood components used, and the use of filtered blood components as the equivalent of CMV seronegative-screened products.


CONCLUSIONS
The use of leukocyte-reduced blood components significantly diminishes or prevents many of the adverse transfusion reactions associated with donor white blood cells. Leukocyte removal filters are cost-effective, and filters should be selected based on their ability to consistently achieve low leukocyte residual levels as well as their ease of use.


CONCLUSIONS
Physicians may order leukocyte-reduced blood components for specific patients, or the components may be used because of an established institutional transfusion policy. Nurses often participate in deciding on a filtration method, primarily based on ease of use. Understanding the considerations in selecting a filtration method will help nurses make appropriate decisions to ensure quality patient care.
Higgins
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Pall Biomedical Products Company, Division of Pall Corporation, East Hills, NY, USA.
D017046:Cost Savings; D003362:Cost-Benefit Analysis; D005374:Filtration / Q000295:instrumentation; D006801:Humans; D007108:Immune Tolerance; D017053:Infection Control; D007937:Leukapheresis / Q000191:economics / Q000295:instrumentation / Q000379:methods* / Q000451:nursing; D065227:Transfusion Reaction