Topogenesis of inner membrane proteins of mitochondria.
Proteins of the inner mitochondrial membrane display a diverse range of topological arrangements. These proteins, encoded either by the nuclear or mitochondrial genomes, contain sequence determinants, so-called topogenic signals, which direct newly synthesized proteins to their final orientation in the membrane. The recent analysis of sorting pathways of a number of proteins highlights that these topogenic signals might act in different ways.
Stuart
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Institut für Physiologische Chemie, Universität München, Germany. neupert@bio.med.uni-muenchen.de
Neupert
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D016678:Genome; D007425:Intracellular Membranes / Q000737:chemistry*; D008565:Membrane Proteins / Q000235:genetics*; D008928:Mitochondria / Q000737:chemistry* / Q000648:ultrastructure; D008969:Molecular Sequence Data
D008565:Membrane Proteins