[Peritoneal blood flow and peritoneal transfer parameters during intermittent peritoneal dialyses performed with administration of sodium nitroprusside or chlorpromazine].
Effective peritoneal capillary blood flow (EPBF) was evaluated by calculation of diffusive mass transport coefficient of CO2 during intermittent peritoneal dialysis performed with intraperitoneal administration of sodium nitroprusside (NP, 5 mg/l of dialysis solution) or chlorpromazine (Cl-Prom, 2.5 mg/l of dialysis solution). Peritoneal transfer rates of substances of different molecular size and charge were simultaneously examined and compared with EPBF. During NP or Cl-Prom administration, EPBF was respectively 220 +/- 40 (n = 11) and 224 +/- 29 (n = 10) ml/min. These values were insignificantly higher than those obtained during dialyses without drugs (169 +/- 16 ml/min, n = 10). NP and Cl-Prom did not cause any significant changes in peritoneal transfer of CO2. Transfer rates of HCO3 and tCO2 were increased only with NP. Both drugs enhanced peritoneal removal of Na+, K+, urea, uric acid and total protein, but with similar EPBF during the use of both drugs, the effect of NP was more pronounced. The obtained results indicate that EPBF is not a major factor responsible for enhanced peritoneal transfer rates during dialyses performed with NP or Cl-Prom.
Grzegorzewska
A
A
Z Kliniki Nefrologii IChW, Akademii Medycznej, im. Karola Marcinkowskiego w Poznaniu.
Barcz
M
M
Kriczi
M
M
Antoniewicz
K
K
D002245:Carbon Dioxide / Q000493:pharmacokinetics; D002746:Chlorpromazine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D009599:Nitroprusside / Q000008:administration & dosage*; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000098:blood supply*; D011506:Proteins / Q000493:pharmacokinetics; D012039:Regional Blood Flow / Q000187:drug effects; D014508:Urea / Q000493:pharmacokinetics
D011506:Proteins; D002245:Carbon Dioxide; D009599:Nitroprusside; D014508:Urea; D002746:Chlorpromazine
Otrzewnowy przepływ krwi a wskaźniki transferu otrzewnowego podczas przerywanych dializ otrzewnowych z podawaniem nitroprusydku sodowego lub chlorpromazyny.