[Western blot analysis of serum autoantibodies against inner ear antigens in patients with systemic lupus erythematosus].
The purpose of this study was to identify the cross-reacting autoantibodies against inner ear antigens in patients with systemic lupus erythematosus (SLE). Inner ear antigens of guinea pigs were prepared. The sera from 18 patients with SLE without hearing loss and 11 normal subjects were analysed by immunoblotting assay. The results showed that 16 patients with SLE had cross-reacting autoantibodies, while 11 normal objects were all negative (P < 0.01), these suggested that the inner ear may be one of the targets involved by SLE. To further investigate the correlation between hearing status of SLE and autoantibodies against inner ear antigens will be of great value to explore the pathogenesis of inner ear insults resulted from certain systemic autoimmune diseases.
Xiao
H
H
Union Hospital, Tongji Medical University, Wuhan.
Wang
J
J
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D007758:Ear, Inner / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies