[The effect of the Russian inhalant glucocorticosteroid budesonide on bronchial inflammation and hyperreactivity during the long-term treatment of bronchial asthma patients].
11 patients with severe bronchial asthma entered a randomized trial of glucocorticosteroid budesonide of Russian produce. Of them 6 patients received inhalations of budesonide (800 micrograms/day for 6 months), 5 control patients did not receive the drug. As shown by investigations of external respiration and bronchoalveolar lavage with estimation of cytogram, metacholine provocative tests, fiber bronchoscopy, budesonide inhalations relieved clinical symptoms of asthma, bronchial hyperreactivity and inflammation.
Sutochnikova
O A
OA
Samsonova
M V
MV
Cherniak
A V
AV
Cherniaev
A L
AL
Sokolov
A S
AS
Chuchalin
A G
AG
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D001991:Bronchitis / Q000175:diagnosis / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D001999:Bronchoscopy; D019819:Budesonide; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011282:Pregnenediones / Q000008:administration & dosage*
D000336:Aerosols; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D011282:Pregnenediones; D019819:Budesonide
Vliianie otechestvennogo ingaliatsionnogo gliukokortikosteroida budesonida na vospalenie i giperreaktivnost' bronkhov pri dlitel'nom lechenii bol'nykh bronkhial'noĭ astmoĭ.