title: Immunoelectron microscopic changes of the platelet plasma membrane after activation.
abstract: The observation of protein redistributions from one compartment to another during platelet activation reflects changes in platelet functionality. At rest alpha-granules express a high level of the main aggregation receptor GPIIb/IIIa, and only a small amount of the adhesion receptor complex GPIb/IX/V which lines the plasma membrane. After activation, the plasma membrane loses GPIb whereas the level of expression of the other aggregative proteins such as GPIIb/IIIa increase. These observations correlate well with the passage of the platelet from an adhesive to an aggregative state.
authors: INSERM U91, Hôpital Henri Mondor, Créteil, France.
authors: E
authors: E
authors: Cramer
authors: G
authors: G
authors: Berger
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D001792:Blood Platelets / Q000648:ultrastructure*; D018955:CD36 Antigens / Q000032:analysis; D002462:Cell Membrane / Q000648:ultrastructure; D005165:Factor V / Q000032:analysis; D006801:Humans; D008562:Membrane Glycoproteins; D016253:Microscopy, Immunoelectron; D015539:Platelet Activation; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000032:analysis; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis; D060245:Tetraspanin 29
chemical_list: D015703:Antigens, CD; D018955:CD36 Antigens; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D060245:Tetraspanin 29; D005165:Factor V