Glutathione amide and its perthiol in anaerobic sulfur bacteria.
Chromatium species produced the novel biological thiol glutathione amide, gamma-L-glutamyl-L-cysteinylglycine amide (GASH), when grown photoheterotrophically. GASH was largely converted to the corresponding perthiol during photoautotrophic growth on sulfide, suggesting that GASH may have a function in anaerobic sulfide metabolism. This unprecedented form of glutathione metabolism was probably present in anaerobic ancestors of modern cyanobacteria and purple bacteria.
Bartsch
R G
RG
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093, USA.
Newton
G L
GL
Sherrill
C
C
Fahey
R C
RC
D000693:Anaerobiosis; D002844:Chromatium / Q000254:growth & development / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism
D013438:Sulfhydryl Compounds; C101019:glutathione amide; D005978:Glutathione