Upregulation of calcitonin gene-related peptide at mouse motor nerve terminals poisoned with botulinum type-A toxin.
Calcitonin gene-related peptide (CGRP)-like immunoreactivity of motor nerve terminals was investigated at different times after local in vivo injection of botulinum type-A toxin (BoNT/A) close to the mouse levator auris longus muscle. CGRP expression in most of control nerve terminals was undetectable, but markedly increased during muscle paralysis and synaptic remodelling and, declined once functional recovery occurred.
Meunier
F A
FA
Laboratoire de Neurobiologie Cellulaire et Moléculaire, C.N.R.S. (U.P.R.9040), Gif-sur-Yvette, France.
Colasante
C
C
Faille
L
L
Gastard
M
M
Molgó
J
J
D000818:Animals; D019274:Botulinum Toxins, Type A / Q000633:toxicity*; D015740:Calcitonin Gene-Related Peptide / Q000096:biosynthesis*; D004594:Electrophysiology; D007150:Immunohistochemistry; D007834:Lasers; D051379:Mice; D018613:Microscopy, Confocal; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D015854:Up-Regulation / Q000187:drug effects*
D019274:Botulinum Toxins, Type A; D015740:Calcitonin Gene-Related Peptide