title: Androgenic control of 1-alkyl-2,3-diacylglycerol in the harderian gland of the golden hamster, Mesocricetus auratus.
abstract: Harderian glands of golden hamsters produce a copious lipid secretion, most of which is in the form of 1-alkyl-2,3-diacylglycerol (ADG). Sexual differences are seen in the composition of golden hamster ADG and in the morphology of secretory lipid droplet. ADGs from females contained abundant iso- and anteiso-branched chain alkyl groups and fatty acids [Seyama, Y., Otsuka, H., Ohashi, K., Vivien-Roels, B., and Pevet, P. (1995) J. Biochem. 117, 661-670]. Female hamsters were either untreated or given subcutaneous testosterone pellets. Treatment of females with testosterone led to the disappearance of such branched chain alkyl groups and fatty acids. Intact males had ADGs with entirely saturated straight chain alkyl groups and fatty acids. Castration led to the appearance of iso- and anteiso-branched chain alkyl groups and fatty acids. These observations suggested that the production of branched chain fatty acids in the Harderian gland of golden hamster is inhibited by testosterone at the step of isovaleryl-CoA dehydrogenase and 2-methyl branched-chain acyl-CoA dehydrogenase
authors: Department of Physiological Chemistry and Nutrition, University of Tokyo.
authors: Y
authors: Y
authors: Seyama
authors: A
authors: A
authors: Hida
authors: S
authors: S
authors: Hayashi
authors: G R
authors: GR
authors: Buzzell
mesh_terms: D000475:Alkenes; D000818:Animals; D006224:Cricetinae; D004075:Diglycerides / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry; D005260:Female; D005995:Glyceryl Ethers / Q000032:analysis*; D006243:Harderian Gland / Q000737:chemistry* / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D009919:Orchiectomy; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology* / Q000502:physiology
chemical_list: D000475:Alkenes; D004075:Diglycerides; D005227:Fatty Acids; D005995:Glyceryl Ethers; D013739:Testosterone; C013658:propylene