title: Evaluation of five protocols for quantification of two-dimensional MR spectroscopic images.
abstract: Five protocols were tested for quantification on in vivo two-dimensional spectroscopic imaging datasets. The datasets are duplo measurements from three individuals. The peaks for N-acetyl aspartate, creatines, and cholines were quantified. The first of the protocols is conventional integration of a selected interval around the peak. The others are various implementations of a Gauss-Newton-based least-squares time-domain fitting algorithm. Fitting a half-echo (free-induction decay curve, FID) to a full echo was compared; this was combined with or without filtering out the water signal using the Lanczos-Hankel singular-value decomposition (LHSVD). It appears that conventional integration yields consistent and accurate results in comparison to the fitting methods. The combination of LHSVD and echo fitting performs equally well; advantages and disadvantages are discussed. The protocols using FID fitting perform poorly with these experimental datasets.
authors: MRI-Research, Medisch Spectrum Twente, Enschede, The Netherlands.
authors: A R
authors: AR
authors: Peters
authors: R
authors: R
authors: de Beer
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005069:Evaluation Studies as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016018:Least-Squares Analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline