title: Functional magnetic resonance imaging shows localized brain activation during serial transcranial stimulation in man.
abstract: Area and depth penetration of transcranial stimulation methods such as transcranial electrical stimulation (TES) are poorly defined. We investigated the feasibility of a simultaneous TES and fMRI measurement. The aim was to compare the signal intensity changes measured using BOLD fMRI during sequential finger movement with the signal response during artificial transcranial stimulation. Tes induced contralateral finger contractions and in T2* weighted images a transient signal increase was observed in the area underlying the electrodes. Compared with the signal obtained during sequential finger movements, the area activated by TES was more localized, signal amplitude, was smaller and there was no post-stimulus undershoot. These data indicate that TES induces a local blood flow increase associated with a drop in the concentration of deoxyhaemoglobin.
authors: Department of Neurology, Charité, Humboldt-Universität, Berlin, Germany.
authors: S A
authors: SA
authors: Brandt
authors: T L
authors: TL
authors: Davis
authors: H
authors: H
authors: Obrig
authors: B U
authors: BU
authors: Meyer
authors: J W
authors: JW
authors: Belliveau
authors: B R
authors: BR
authors: Rosen
authors: A
authors: A
authors: Villringer
mesh_terms: D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004558:Electric Stimulation; D004566:Electrodes; D005385:Fingers / Q000294:innervation / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000098:blood supply / Q000502:physiology; D009068:Movement / Q000502:physiology
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin