[Lomir in the treatment of arterial hypertension after angioplastic surgery].
Isradipine (lomir) is a new highly selective arteriolar vasodilator of the dihydropyridine group, characterized by a slight cardiodepressive effect. The drug effect on the central hemodynamics and oxygen transport was studied after cardiovascular surgery. Arterial pressure and total peripheral vascular resistance were reliably reduced at the peak of the drug action, as was the left-ventricular stroke work and oxygen consumption. A tendency to increase of cardiac output and cardiac index was observed. Pulmonary vascular resistance and pressure in the pulmonary artery did not reliably change. The drug increased the intrapulmonary shunt.
Lebedeva
R N
RN
Eremenko
A A
AA
Ziuliaeva
T P
TP
Mikhaĭlov
Iu M
IuM
Matiunin
A V
AV
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001012:Aorta, Abdominal / Q000601:surgery; D001243:Assisted Circulation; D001807:Blood Vessel Prosthesis; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D002339:Carotid Arteries / Q000601:surgery; D001026:Coronary Artery Bypass; D004691:Endarterectomy; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D006324:Heart Arrest, Induced; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017275:Isradipine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D011183:Postoperative Complications; D013895:Thoracic Arteries / Q000601:surgery; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D017275:Isradipine
Lomir v lechenii arterial'noĭ gipertenzii posle angioplasticheskikh operatsiĭ.