Suppression of humoral immunity by monoclonal antibody to CD79b, an invariant component of antigen receptors on B lymphocytes.
CD79b is an invariant component of antigen receptors on B lymphocytes. Previous data have suggested that monoclonal antibody (mAb) to CD79b would introduce negative signals into B lymphocytes and suppress humoral immunity. We tested this hypothesis in this study using in vitro assay systems, and revealed that anti-CD79b mAb effectively suppressed the antibody response to a T-cell dependent antigen. The speculated mechanisms for this immunosuppression were: (i) down-modulation of antigen receptors, (ii) inhibition of B lymphocyte differentiation, and (iii) induction of B lymphocyte unresponsiveness. Of these three, we confirmed that the first two were actually induced by anti-CD79b mAb treatment, whereas the in vitro system could not induce the unresponsiveness of B lymphocytes.
Nakamura
T
T
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Koyama
M
M
Koike
Y
Y
Miyazaki
K
K
Yoneyema
A
A
Higashihara
M
M
Azuma
M
M
Kurokawa
K
K
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000917:Antibody Formation; D015703:Antigens, CD / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D051925:CD79 Antigens; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D051925:CD79 Antigens; C497883:CD79B protein, human; D011947:Receptors, Antigen, B-Cell