The effect of surgical castration on lipid metabolism in premenopausal and postmenopausal women.
OBJECTIVE
To investigate the effect of endogenous estrogen on lipid and lipoprotein metabolism in premenopausal and postmenopausal women.


METHODS
Prospective randomized study.


METHODS
Department of Obstetrics-Gynecology, Beilinson Medical Center and Tel-Aviv University Medical School, Israel.


METHODS
Twenty-seven women, 15 premenopausal and 12 postmenopausal, undergoing surgical castration (total abdominal hysterectomy and bilateral salpingo-oophorectomy).


METHODS
Blood samples were drawn before the surgical intervention and after a 6-month interval.


METHODS
Assays were performed for estradiol, luteinising hormone and follicle-stimulating hormone, and triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and total cholesterol/HDL as well as HDL/LDL ratio.


RESULTS
No significant differences were found in both groups, before castration and after 6 months. A modest, but statistically significant, rise in triglycerides was observed in the premenopausal group.


CONCLUSIONS
The serum lipid and lipoprotein profile encountered in premenopausal and postmenopausal women were unchanged 6 months after surgical castration. The clinical significance indicates that the effect of endogenous estrogen on lipid metabolism is doubtful and should be further investigated.
Goldman
G A
GA
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah-Tikva, Israel.
Schoenfeld
A
A
Royburt
M
M
Zeldin
L
L
Kaplan
B
B
Ovadia
J
J
D000328:Adult; D000368:Aged; D004967:Estrogens / Q000502:physiology*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause / Q000097:blood*; D011184:Postoperative Period; D017697:Premenopause / Q000097:blood*; D011446:Prospective Studies
D004967:Estrogens; D008055:Lipids