title: Apomorphine SC treatment in parkinsonian patients with long-term L-dopa syndrome during L-dopa drug holiday.
abstract: The Long-Term Dopa Syndrome (LTDS) is one of the main problems in the management of advanced parkinsonian patients. A transient L-Dopa withdrawal (Drug Holiday, DH) can be useful to improve the drug response after DH, even if this approach presents risks due to patient akinesia. We tried to verify if Apomorphine sc administration during DH (DH with Apomorphine, DHA) can: a) reduce the risks connected with DH: b) maintain the benefits of DH: c) standardize the duration of DH. Twenty-five parkinsonian patients with LTDS were treated with Apomorphine sc during DH (14 days). No patient had any severe side effects. The follow-up at 180 days, conducted using the Unified Parkinson's Disease Rating Scale, demonstrated a significant improvement in the clinical conditions of about 70% of the patients, allowing a 27.1% reduction in daily L-dopa dosage. DHA can represent a valid therapeutical approach for parkinsonian patients with LTDS.
authors: Department of Neurology, University of Turin, Italy.
authors: L
authors: L
authors: Scarzella
authors: M
authors: M
authors: Delsedime
authors: B
authors: B
authors: Ferrero
authors: C
authors: C
authors: Giangrandi
authors: L
authors: L
authors: Priano
authors: M
authors: M
authors: Rizzone
authors: B
authors: B
authors: Bergamasco
mesh_terms: D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001058:Apomorphine; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000187:drug effects*; D015259:Dopamine Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D012307:Risk Factors; D012867:Skin; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents; D004295:Dihydroxyphenylalanine; D001058:Apomorphine