title: Antiplatelet flavonoids from seeds of Psoralea corylifolia.
abstract: The MeOH extract of the seeds of Psoralea corylifolia L. was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid, collagen, and platelet activating factor. Bioassay-directed fractionation led to the isolation of three flavonoids, isobavachalcone (1), neobavaiso-flavone (2), and bavachin (3). Compounds 1 and 2 inhibited platelet aggregation.
authors: National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
authors: W J
authors: WJ
authors: Tsai
authors: W C
authors: WC
authors: Hsin
authors: C C
authors: CC
authors: Chen
mesh_terms: D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013624:Taiwan
chemical_list: D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors