[Prevention and treatment effect of niacin on FES: experimental study].
OBJECTIVE
On the basis of fat embolism syndrome animal model injected with homologous dog bone marrow fat, we probed into the prevention and treatment effect of niacin on FES.


METHODS
Fourteen dogs were divided into experimental group and control group. In the experimental group, the dogs were injected with homologous dog bone marrow fat accompanied by niacin injection 4 mg/kg. 8 hr intravenously for 48 hours, while in the control group, only bone marrow fat was injected. PaO2, FFA, triglyceride, platelet counts, fat drops in the blood clots of vein were examined at different times. Finally, morphology and pathology of the lungs were observed.


RESULTS
There were a slower decrease in PaO2 and platelet counts and no obvious increase in triglycerides and FFA in the experimental group. The amount and diameter of fat drops in the blood clots of vein and in the lungs were less in the experimental group than in the control. Pathological examinations of the lungs demonstrated much less injuries in the experimental group.


CONCLUSIONS
Good prevention and treatment effect of niacin on fat embolism syndrome is suggested.
Zhang
B
B
Orthopaedic Department, General Hospital of PLA, Beijing.
Zhang
Q
Q
Lu
S
S
D000818:Animals; D004285:Dogs; D004620:Embolism, Fat / Q000517:prevention & control*; D009525:Niacin / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011897:Random Allocation
D010975:Platelet Aggregation Inhibitors; D009525:Niacin; D010100:Oxygen