Can receptor editing play an important role in normal B-cell development?
B-cells bearing in-frame light chain rearrangements often continue to rearrangement light chain genes, in apparent contradiction to the rules of allelic exclusion. The potential role of B-cell receptor self-reactivity in this process is discussed in the context of the possible efficiency of rescue of the autoreactive cells and the observed high frequency of peripheral B-cells that rearrange only a single light chain locus.
Nemazee
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Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D011947:Receptors, Antigen, B-Cell / Q000235:genetics* / Q000276:immunology
D011947:Receptors, Antigen, B-Cell