Hitchcock's experimental series of foetal implants for Parkinson's disease: co-grafting ventral mesencephalon and striatum.
Following 4 previous experimental series of foetal implants (mesencephalon) to treat patients with Parkinson's disease subjects (N7) in the fifth series were treated with co-grafts of foetal mesencephalon and striatum implanted stereotactically into the caudate nucleus bilaterally. The clinical outcome, better than in the previous series, included improvements lasting through 18 months follow-up in activities of daily living, clinical neurological motor examination, timed motor tasks, and dyskinesia-with reduction in the patients' need for dopaminergic medication.
Meyer
C H
CH
Midland Centre for Neurosurgery and Neurology, Birmingham, U.K.
Detta
A
A
Kudoh
C
C
D016380:Brain Tissue Transplantation / Q000502:physiology*; D002421:Caudate Nucleus / Q000601:surgery; D003342:Corpus Striatum / Q000637:transplantation*; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000637:transplantation*; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome