title: Effects of prostaglandin antagonist phloretin derivatives on mouse ear edema induced with different skin irritants.
abstract: Edema was induced in one ear of male mice of the CFLP strain with solutions of different skin irritants (croton oil 10 microL/35 micrograms, dithranol 10 microL/30 micrograms, capsaicin 10 microL/40 micrograms or arachidonic acid to 10 microL/2 mg per ear). Edema, determined by the edema-disk gravimetric technique, was inhibited in a dose-dependent manner by the intraperitoneally administered prostaglandin antagonists polyphloretin phosphate (PPP) or di-4-phloretin phosphate (DPP). With croton oil-induced mouse ear edema, DPP 10 mg/kg caused a 38% inhibition, PPP 25 mg/kg a 33% inhibition. With dithranol-induced edema DPP 0.5 mg/kg caused a 57% inhibition, while PPP 25 mg/kg was needed to exert a similar effect. Doses of DPP and PPP needed to cause a > 40% inhibition of edema were 10 mg/kg and 25 mg/kg, respectively, for capsaicin, and 25 mg/kg and 100 mg/kg for arachidonic acid. The inhibition of the ear edema by the phloretin derivatives was: dithranol > croton oil > capsaicin > arachidonic acid. This probably reflects the different contributions of prostaglandins to the inflammation.
authors: Department of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors: G
authors: G
authors: Blazsó
authors: M
authors: M
authors: Gábor
mesh_terms: D000818:Animals; D000875:Anthralin; D016718:Arachidonic Acid; D002211:Capsaicin; D003436:Croton Oil; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007509:Irritants; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011121:Polyphloretin Phosphate / Q000627:therapeutic use*; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*
chemical_list: D007509:Irritants; D011448:Prostaglandin Antagonists; D016718:Arachidonic Acid; C013509:diphloretin phosphate; D003436:Croton Oil; D011121:Polyphloretin Phosphate; D002211:Capsaicin; D000875:Anthralin