Effect of two cardiac glycosides, digitoxin and digoxin on blood lipids.
Two cardiac glycosides, namely digitoxin and digoxin when treated with goat blood, were found to alter the lipid constitution as measured by their phosphorus content, fatty acid composition and malonaldehyde content. There was significant increase in the poly-unsaturated fatty acids (PUFA) and malonaldehyde contents in blood treated with these drugs. Possible correlation between the lipophilicity of the drugs and their biological activity is discussed.
Dutta
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta.
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Sengupta
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D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004074:Digitoxin / Q000494:pharmacology*; D004077:Digoxin / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006041:Goats; D008055:Lipids / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D002316:Cardiotonic Agents; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D004077:Digoxin; D004074:Digitoxin