Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster.
The thoracic integument of the adult fruit fly is a relatively simple but highly patterned structure. It is composed of sensory organ cells distributed within a monolayer of epidermal cells. Both cell types are easily detected at the cuticular surface, as each external sense organ forms a sensory bristle and each epidermal cell secretes a small nonsensory hair. Inhibitory cell-cell interactions play a key role in regulating the distribution as well as the formation of the sense organs. This review focuses on the role of these cell-cell interactions in the adoption of alternative cell fates. We also show that Notch, Hairless, and Suppressor of Hairless, three components of this intercellular signaling pathway, exhibit dose-dependent genetic interactions. Finally we address how this intercellular signaling mechanism may be modulated to result in highly reproducible outcomes.
Schweisguth
F
F
Institute Jacques Monod, University of Paris, France.
Gho
M
M
Lecourtois
M
M
D000818:Animals; D002450:Cell Communication; D003433:Crosses, Genetic; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D017344:Genes, Insect; D006358:Hot Temperature; D008297:Male; D008465:Mechanoreceptors / Q000166:cytology / Q000502:physiology; D008565:Membrane Proteins / Q000096:biosynthesis; D008954:Models, Biological; D009420:Nervous System / Q000166:cytology*; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000166:cytology / Q000502:physiology; D014176:Protein Biosynthesis; D011679:Pupa; D051880:Receptors, Notch; D015398:Signal Transduction; D014157:Transcription Factors
D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; D014157:Transcription Factors