The effect of anisodamine on cerebral resuscitation of rats in acute cerebral ischemia from cardiac arrest.
In order to investigate the mechanisms of acute cerebral ischemia, and to look for effective drugs on cerebral resuscitation, we made a model of acute complete global brain ischemia, reperfusion and resuscitation on rats according to Garavilla's method. Our results showed that the event of cerebral ischemia and reperfusion injury could result in the increase of total brain calcium content, and anisodamine has the same reducing brain calcium contents as diltiazem's, while improving neurological outcome and alleviating injury to neurons.
Peng
X
X
Department of Pharmacology, Henan Medical University, Zhengzhou.
Coa
S
S
Ke
J
J
D000818:Animals; D002545:Brain Ischemia / Q000150:complications*; D002118:Calcium / Q000378:metabolism*; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D002118:Calcium