title: Expression of HLA-DR antigen in large bowel carcinoma.
abstract: One hundred large bowel carcinomas were studied immunohistochemically with regard to expression of HLA-DR antigen (DR). One or two sections from each tumor including surrounding normal mucosa were examined by a semiquantitative counting system for tumor cells and mucosal and stromal infiltrates of lymphocytes and mononuclear cells (MNCs) with DR expression and the results were applied Chi-square test. The rate of presence of DR positive (DR+) lymphocytes in lymphoid nodules and DR+ lymphocytes/ MNC in the adjacent mucosa and stroma in DR+ carcinoma (50%) was higher (P < 0.01) than in DR- carcinoma (21.9%). Thirty-six carcinomas (36%) were DR+. Three (75%) out of 4 DR+ poorly differentiated carcinomas and six (20%) out of 30 DR+ moderately differentiated carcinomas showed homogeneously strong DR+ expression. There was tendency for poorly differentiated carcinoma to be more homogeneous DR+ expression. According to Dukes' stage, four (80%) out of 5 carcinomas in Dukes' stage D were DR-. An increased infiltration of lymphocytes/MNCs into adjacent mucosa and stroma in large bowel carcinomas is possibly related with DR expression by carcinoma. From the results of this study, we postulated as follows: 1) DR+ tumor cells may act as antigen-presenting cells, 2) They may have an inhibitory effect for distant metastasis, 3) Poorly differentiated carcinoma expressed more DR+ homogeneously.
authors: Department of Pathology, Keimyung University Dongsan Medical Center, Jung-gu, Taegu, Korea.
authors: E S
authors: ES
authors: Chang
authors: S S
authors: SS
authors: Sohn
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies; D015179:Colorectal Neoplasms / Q000097:blood / Q000737:chemistry* / Q000473:pathology; D004848:Epithelium / Q000737:chemistry; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D000906:Antibodies; D006684:HLA-DR Antigens