Two hypothetical proteins of human aortic adventitia, with Ig kappa, collagenous, and aromatic-rich motifs.
Two of five clones, selected from an expression library of aortic adventitia, encode unique hypothetical proteins sharing sequences of Ig kappa, gly/pro rich (collagenous) motifs, and aromatic motifs that occur in several proteins of the extracellular matrix. Both proteins have a similar domain structure with at least 8 regions: (1) Ig kappa (84-120 residues in length); (2) ser/thr-rich motif (44-63); (3) a second Ig kappa motif (9-12); (4) either a possible calcium-binding motif or a gly/pro rich sequence (35-43); (5) an aromatic rich sequence (6-7); (6) another gly/pro rich sequence (62-72); (7) a third Ig kappa sequence (26-28); and (8) a C-terminal 68-70 residue sequence with another aromatic motif.
Ozsvath
K J
KJ
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA.
Xia
S
S
Hirose
H
H
Tilson
M D
MD
D000595:Amino Acid Sequence; D001011:Aorta / Q000378:metabolism*; D003094:Collagen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D007145:Immunoglobulin kappa-Chains; D009124:Muscle Proteins; D003094:Collagen