title: Total leucoderma: a rare manifestation of cutaneous chronic graft-versus-host disease.
abstract: We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.
authors: Department of Bone Marrow Transplantation, Hebrew University, Jerusalem, Israel.
authors: A
authors: A
authors: Nagler
authors: M A
authors: MA
authors: Goldenhersh
authors: F
authors: F
authors: Levi-Schaffer
authors: J C
authors: JC
authors: Bystryn
authors: S N
authors: SN
authors: Klaus
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000276:immunology; D010859:Pigmentation Disorders / Q000209:etiology* / Q000473:pathology
chemical_list: D001323:Autoantibodies; D008543:Melanins