Granulocyte adhesion molecules--structure/function relationships.
Neutrophil responses are regulated by cellular adhesion events, including interaction with extracellular matrix and other cell types. The diversity of molecular structures which are included in the repertoire of cell adhesion molecules expressed by neutrophils and their subtle regulation allow fine tuning of cell adhesion processes to suit environmental demands. This article reviews some of the recent findings using biochemical, immunochemical and molecular techniques that allow the relationship between adhesion molecule structure and function to be examined. Understanding the molecular basis of cell adhesion events will allow development of novel strategies that allow manipulation of adhesion processes in a clinical setting.
Dransfield
I
I
Department of Medicine, University of Edinburgh Medical School, UK.
D000595:Amino Acid Sequence; D001665:Binding Sites; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D016023:Integrins / Q000737:chemistry / Q000276:immunology*; D007477:Ions; D008024:Ligands; D008670:Metals; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000276:immunology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; D007477:Ions; D008024:Ligands; D008670:Metals