Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons.
In this study, we demonstrated that the tyrosine hydroxylase-like immuno-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.
Yamada
M
M
Department of Psychiatry, Mayo Clinic Jacksonville, FL 32224, USA.
Bolden-Watson
C
C
Watson
M A
MA
Cho
T
T
Coleman
N J
NJ
Yamada
M
M
Richelson
E
E
D000818:Animals; D015415:Biomarkers; D002421:Caudate Nucleus / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009928:Organ Specificity; D011720:Pyrazoles / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D015347:RNA Probes; D016372:RNA, Antisense; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D012016:Reference Values; D013378:Substantia Nigra / Q000378:metabolism; D013681:Tegmentum Mesencephali / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D015415:Biomarkers; D011720:Pyrazoles; D011804:Quinolines; D015347:RNA Probes; D016372:RNA, Antisense; D012333:RNA, Messenger; D018028:Receptors, Neurotensin; C079087:SR 48692; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine