Intralesional steroids in Langerhans cell histiocytosis of bone.
Langerhans cell histiocytosis may involve single or multiple organ systems. Bone involvement is the most common feature. We have examined retrospectively the effects of 20 intralesional injections of steroids into bone in seven patients seen at our department from 1988 to 1993. Most of these injections (75%) relieved the symptoms, and no side-effects were observed. However, injections into the jaw were seldom effective. Our results suggest that the dose of the steroids administered is of importance.
Bernstrand
C
C
Department of Paediatrics, Karolinska hospital, Karolinska Institute, Stockholm, Sweden.
Björk
O
O
Ahström
L
L
Henter
J I
JI
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001847:Bone Diseases / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D008776:Methylprednisolone Hemisuccinate