Radiopharmaceutical dosage of 99Tcm-HMPAO for cerebral blood flow SPET studies in children.
Four methods of calculating the activity of 99Tcm-hexamethylpropyleneamine oxime to be administered in cerebral blood flow investigations of children were evaluated in patient studies. Three of the methods were based on the size of the child. We also constructed a theoretical dosage model based on physiological data and attenuation effects. The aim of the study was to find a dosage calculation method that gave the same image quality for children of all ages as well as for adults. The results showed that the dosage method based on body weight is the only one of the four methods that does not exhibit an age-dependent variation in image quality and therefore this method is recommended.
Vestergren
E
E
Department of Radiation Physics, University of Göteborg, Sweden.
Jacobsson
L
L
Bjure
J
J
Sixt
R
R
Mattsson
S
S
D000293:Adolescent; D000328:Adult; D001827:Body Height; D001835:Body Weight; D002302:Cardiac Output; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008962:Models, Theoretical; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010091:Oximes / Q000493:pharmacokinetics; D019690:Technetium Tc 99m Exametazime; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime