Evaluation of an immunoradiometric assay for thyrotropin in serum and plasma samples of dogs with primary hypothyroidism.
A commercially available immunoradiometric assay was used to measure the thyrotropin (TSH; thyroid-stimulating hormone) concentration in the serum and plasma of 23 dogs. The basal concentration in five dogs with histologically confirmed primary hypothyroidism (median 0.18 microg/l, range 0.16-0.72 microg/l) was slightly, but not significantly, higher than that in 13 clinically healthy dogs (median 0.09 microg/l, range 0.06-0.34 microg/l). The TSH values in 11 euthyroid dogs with various dermatological diseases (median 0.09 microg/l, range 0.05-0.53 microg/l) were significantly lower than in the hypothyroid dogs, but there was considerable overlap. The assay alone was therefore not capable of giving a firm diagnosis.
Jensen
A L
AL
Central Laboratory, Department of Clinical Studies, Royal Veterinary and Agricultural University, Fredriksberg, Denmark.
Iversen
L
L
Høier
R
R
Kristensen
F
F
Henriksen
P
P
D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D015592:Immunoradiometric Assay / Q000662:veterinary*; D008297:Male; D011933:Reagent Kits, Diagnostic; D013972:Thyrotropin / Q000097:blood*
D011933:Reagent Kits, Diagnostic; D013972:Thyrotropin