Ubiquitin expression in degenerating axons of equine cervical compressive myelopathy.
Neuropathologic examination revealed axonal swelling and breakdown leading to Wallerian degeneration of affected myelinated nerve fibers in the spinal cord white matter of four young horses with equine cervical compressive myelopathy. Immunohistochemical reactions for the cell stress protein ubiquitin revealed an enhanced presence in the swollen axons, which may reflect a role for ubiquitin in the neuronal catabolic process of axonal compression and degeneration in this myelopathy.
Jortner
B S
BS
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061-0442, USA.
Scarratt
W K
WK
Modransky
P D
PD
Walton
A
A
Perkins
S K
SK
D000818:Animals; D001369:Axons / Q000737:chemistry* / Q000473:pathology / Q000502:physiology; D005260:Female; D006734:Horse Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006736:Horses; D007150:Immunohistochemistry; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology*; D009412:Nerve Fibers / Q000737:chemistry / Q000473:pathology / Q000502:physiology; D012189:Retrospective Studies; D013116:Spinal Cord / Q000473:pathology; D013117:Spinal Cord Compression / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D013577:Syndrome; D014452:Ubiquitins / Q000032:analysis* / Q000378:metabolism
D014452:Ubiquitins