[A 26-week repeated percutaneous dose toxicity study of calcipotriol (MC903) in dogs].
A 26-week repeated percutaneous dose toxicity of calcipotriol (MC903), an anti-psoriasic agent, was studied in beagle dogs at doses of 0.04, 0.4 and 4 micrograms/kg/day. 1. In general conditions, reddening, rash, desquamation, pruritus, wet and hot skin at 4 micrograms/kg/day, reddening, rash and desquamation at 0.4 microgram/kg/day, pruritus and desquamation at 0.04 microgram/kg/day, were observed at the skin of application site. 2. In urinalysis, an increase or a tendency to an increase in Ca level, were observed at 4 micrograms/kg/day. 3. Histopathological examinations revealed squamous cell hyperplasia and parakeratosis at the skin of application site in both sexes at 4 micrograms/kg/day. However, these findings were not shown at the skin of application site at 0.4 and 0.04 microgram/kg/day. 4. On the basis of results obtained in the present study, it is considered that 0.4 microgram/kg/day is the no-toxic dose of MC903 applied percutaneously in both sexes of beagle dogs.
Imaizumi
T
T
Japan Seigiken Research Center Co., Ltd., Shizuoka, Japan.
Tsuruta
M
M
Koike
Y
Y
Ono
M
M
Shirakawa
K
K
Nagata
M
M
Konishi
R
R
D000279:Administration, Cutaneous; D000818:Animals; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D002118:Calcium / Q000652:urine; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D006965:Hyperplasia; D007642:Keratosis / Q000139:chemically induced; D008297:Male; D011537:Pruritus / Q000139:chemically induced; D012867:Skin / Q000187:drug effects / Q000473:pathology
D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol; D002118:Calcium