[An experimental study on effects of form deprivation on development of myopia].
OBJECTIVE
The study was designed to approach the pathogenesis of myopia.


METHODS
Haisaik chickens were used to establish the animal models of myopia and form deprivation method was applied. Monocular eyelids were sutured for form deprivation on the 5th day after chicken birth.


RESULTS
Form deprivation leads to myopic refractive abnormality (P < 0.001). The ocular anteroposterior axis (P < 0.005), transverse and vertical diameters lengthen (P < 0.05). In the mean time, obvious pathologic changes were found. The cartilaginous cell layer of the sclera became thicker, the numbers of chondrocytes and binucleate cells were greater, and the fibrous layer of the sclera was thinner.


CONCLUSIONS
Form deprivation is the main cause of the development of myopia.
Wang
F
F
Department of Ophthalmology, First Affiliated Hospital of Qiqihar Medical College.
Wu
G
G
Cong
M
M
D000818:Animals; D002645:Chickens; D005123:Eye / Q000473:pathology*; D005556:Form Perception; D009216:Myopia / Q000209:etiology* / Q000473:pathology; D012029:Refraction, Ocular; D012590:Sclera / Q000473:pathology; D012677:Sensation