Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Tumour necrosis factor-alpha (TNF-alpha) reduced the interstitial fluid pressure (IFP) to 54-64% (P < 0.05) and the mean arterial blood pressure (MABP) to 70% (P < 0.01) of control values after 5 h in three human melanoma tumour lines transplanted to nude mice.
Kristensen
C A
CA
Edwin L Steele Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA.
Nozue
M
M
Boucher
Y
Y
Jain
R K
RK
D000704:Analysis of Variance; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002460:Cell Line; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008545:Melanoma / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011312:Pressure; D012119:Respiration / Q000187:drug effects; D013997:Time Factors; D014183:Transplantation, Heterologous; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
D001639:Bicarbonates; D014409:Tumor Necrosis Factor-alpha; D002245:Carbon Dioxide; D010100:Oxygen