title: [Effect of enhancers on the permeation of ketoprofen in vitro].
abstract: The result of permeability test of ketoprofen (KP) in vitro showed that the penetration process could be described by zero-order kinetics. Azone (AZ), oleic acid (OA), 1-methyl-2-pyrrolidone (2P), dimethylformamide (DMF), propylene glycol (PG) and lauryl alcohol (LA), six penetration enhancers, on the percutaneous absorption of KP were carried out by using isolated shaved mouse skin. These enhancers exhibited different effects. Among the enhancers, OA, AZ, 2P and PG enhanced the skin permeation of KP. Their order of effect was OA > AZ > 2P > PG. AZ and 2P in combination with OA were shown to have synergistic effect. But DMF, LA and PG at high levels inhibited the permeation of KP.
authors: Pharmaceutical Department, Changhai Hospital, Shanghai.
authors: J H
authors: JH
authors: Hu
authors: Y
authors: Y
authors: Zhu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D004357:Drug Synergism; D007660:Ketoprofen / Q000493:pharmacokinetics*; D051379:Mice; D009829:Oleic Acids / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009829:Oleic Acids; D011760:Pyrrolidinones; D007660:Ketoprofen; C038678:N-methylpyrrolidone