In-vitro activity of psychiatric drugs against Corynebacterium urealyticum (Corynebacterium group D2).
We tested the in-vitro activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline, norfloxacin, ciprofloxacin, vancomycin, teicoplanin, clindamycin and five psychiatric drugs (chlorpromazine, sertraline, fluoxetine, paroxetine and risperidone) against 32 strains of Corynebacterium urealyticum. Resistance rates exceeded 90% for all antibiotics except glycopeptides, quinolones and tetracycline. Sertraline was the most active psychiatric drug. We tested the influence of sertraline on the activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline and ciprofloxacin. We did not observe antagonism in any case. Sertraline enhanced the activity of ciprofloxacin and tetracycline against all strains (MIC decrease: 4-64-fold for ciprofloxacin, 2-32-fold for tetracycline).
Muñoz-Bellido
J L
JL
Departamento de Microbiología y Parasitología, Hospital Universitario de Salamanca, Spain.
Muñoz-Criado
S
S
García-Rodríguez
J A
JA
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D003352:Corynebacterium / Q000187:drug effects*; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D017374:Paroxetine / Q000494:pharmacology; D018967:Risperidone / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D020280:Sertraline; D017334:Teicoplanin / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000928:Antidepressive Agents; D005839:Gentamicins; D012702:Serotonin Antagonists; D017374:Paroxetine; D017334:Teicoplanin; D014640:Vancomycin; D000658:Amoxicillin; D015057:1-Naphthylamine; D018967:Risperidone; D002439:Cefotaxime; D020280:Sertraline