Modulation of neuropathic pain in rats by intrathecally injected serotonergic agonists.
The involvement of spinal cord serotonergic influences in the development of autotomy, a proposed behavioural model of denervation pain, was studied in rats subjected to sciatic and saphenous nerve transection 5 min after intrathecal injection of 100 or 200 mu g of several serotonergic receptor subtype agonists. Injection of 8-OH-DPAT, m-CPP, 2-m-5-HT and a low dose of 5-HT, significantly shifted one or more of the parameters describing autotomy to less intense behaviour. In contrast, the injection of CGS-12066B and DOI intensified autotomy. These results suggest both a modulatory role for spinal cord serotonin in the events occurring shortly after neurectomy and new therapeutic approaches for the prevention of certain pain syndromes, such as phantom limb pain.
Sanchez
A
A
Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
Niedbala
B
B
Feria
M
M
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D007278:Injections, Spinal; D008297:Male; D010146:Pain / Q000188:drug therapy*; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
D010879:Piperazines; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C015068:1-(3-chlorophenyl)piperazine