title: Contralateral temporal hypometabolism on positron emission tomography in temporal lobe epilepsy.
abstract: BACKGROUND
  No detailed case studies report lateralised hypometabolism on positron emission tomography (PET) contralateral to the epileptogenic focus in temporal lobe epilepsy (TLE).
  
  
  METHODS
  We performed 18F fluorodeoxyglucose (FDG) PET in two intractable TLE patients.
  
  
  RESULTS
  One had right temporal interictal spikes on electroencephalography (EEG) and a right medial temporal lobe lesion on magnetic resonance imaging (MRI). FDG-PET showed decreased uptake in the left temporal lobe. Right temporal ictal onset, with bilateral interictal epileptiform activity, occurred on intracranial EEG. He is seizure free after right temporal lobectomy and ganglioglioma resection. The second had right temporal lobe interictal and ictal EEG activity. MRI demonstrated right anteriomedial temporal increased T2 signal. Neuropsychology revealed bilateral cognitive dysfunction. FDG-PET showed left anterior temporal and lateral frontal hypometabolism. He is seizure free after right temporal lobectomy.
  
  
  CONCLUSIONS
  These findings suggest that regional uptake asymmetry on FDG-PET may be give misleading lateralising information in TLE.
authors: Comprehensive Epilepsy Center, New York Hospital-Cornell Medical Center, NY 10021, USA.
authors: L
authors: L
authors: Nagarajan
authors: N
authors: N
authors: Schaul
authors: D
authors: D
authors: Eidelberg
authors: V
authors: V
authors: Dhawan
authors: R
authors: R
authors: Fraser
authors: D R
authors: DR
authors: Labar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D004734:Energy Metabolism / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D019788:Fluorodeoxyglucose F18; D018303:Ganglioglioma / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D011612:Psychosurgery; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose