title: The role of arterial hypertension in progression of renal failure.
abstract: The effect of arterial hypertension on the progression of chronic renal failure (CRF) was evaluated in 108 patients who eventually required dialysis in the 8 year period of the study. Patients' average serum creatinine (SCr) concentration at first examination was 239.7 +/- 45.3 mumol/liter and at the start of dialysis was 1,661.0 +/- 181.9 mumol/liter. The mean duration of pre-dialysis follow-up was 53.7 +/- 15.7 months. The mean monthly increase in SCr was 18.8 +/- 13.4 and 2.1 +/- 1.4 mumol/liter/month in hypertensive and normotensive CRF patients, respectively (P < 0.001). The CRF patients with a diastolic blood pressure (BP) < 89 mm Hg had a significantly (P < 0.05) slower rate of decline in renal function than the patients with a diastolic BP > or = 90 mm Hg. There was a significant relationship between a mean diastolic BP > or = 90 mm Hg and the rate of monthly increase in SCr (r = 0.81, P < 0.001). These data indicate that control of diastolic BP in CRF patients is a potentially effective way to slow the rate of decline in renal function.
authors: Department of Nephrology and Dialysis, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
authors: P
authors: P
authors: Kes
authors: I
authors: I
authors: Ratković-Gusić
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001158:Arteries / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D018753:Diet, Protein-Restricted; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000178:diet therapy / Q000209:etiology* / Q000517:prevention & control; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D000959:Antihypertensive Agents; D003404:Creatinine