[Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats].
Treatment of rats with (+/-) gossypol 80 mg.kg-1 or (-) gossypol 40 mg.kg-1 on day 6-9 of gestation terminated early pregnancy. However, (+) gossypol at the dosage of 40 mg.kg-1 was found to have no effect on gestation. (-) Gossypol at a concentration of 30 micrograms.ml-1 showed an inhibitory effect on progesterone production and (+) gossypol at 10 micrograms.ml-1 caused an increase of progesterone secretion by luteal cells in vitro. A marked increase of progesterone level in granulosa cells was elicited by hCG. The steroidogenic response of granulosa cells to hCG was inhibited by (+/-) gossypol at 10 and 30 micrograms.ml-1.
Guan
M Z
MZ
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Wang
N G
NG
D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006072:Gossypol / Q000494:pharmacology*; D006107:Granulosa Cells / Q000378:metabolism; D008184:Luteal Cells / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
D000020:Abortifacient Agents, Nonsteroidal; D011374:Progesterone; D006072:Gossypol