title: Does laser turbinectomy influence local allergic inflammation in the nose?
abstract: The purpose of our study was to evaluate the effects of laser turbinectomy on local allergic inflammation by measuring the secretion of mediators (histamine, bradykinin, and TAME-esterase activity) in nasal lavage fluid after nasal provocation with different allergen concentrations. Our study included 15 patients, aged 15-35 years, who displayed perennial housedust-mite rhinitis (positive prick test, RAST class > 2, and positive nasal provocation with Dermatophagoides pteronyssinus (D.p.) extract) and hypertrophic inferior turbinates. Rhinomanometry (Rhino-test 441, Allergopharma, Germany) and nasal provocation with D.p. extract (Allergopharma, Germany) followed by lavage were performed in all patients. The procedure was repeated three and 12 months after Neodynium:YAG laser turbinectomy. Three and 12 months after laser turbinectomy, we found a significant improvement of nasal flow (p < 0.01 and p < 0.05, respectively) and resistance (p < 0.1 and p < 0.01, respectively) with a tendency towards airway blockage in the long-term follow-up, but no changes in mediator levels of nasal lavages after allergen provocation, suggesting that laser turbinectomy has no effects on local allergic inflammation.
authors: Department of ORL, Benjamin Franklin Medical Center, Free University of Berlin, Germany.
authors: S
authors: S
authors: Jovanovic
authors: D
authors: D
authors: Dokic
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D000485:Allergens; D000818:Animals; D001920:Bradykinin / Q000032:analysis; D004391:Dust / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006632:Histamine / Q000032:analysis; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008365:Manometry; D008925:Mites / Q000276:immunology*; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D009299:Nasal Provocation Tests; D010447:Peptide Hydrolases / Q000032:analysis; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000601:surgery*; D013997:Time Factors; D014420:Turbinates / Q000601:surgery*
chemical_list: D000485:Allergens; D004391:Dust; D006632:Histamine; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase; D001920:Bradykinin