HLA typing and retinitis pigmentosa.
Retinitis pigmentosa is a disease whose pathogenesis remains largely obscure. A lot of evidences support the hypothesis that auto-immunity is involved, but no HLA antigen has ever been associated with retinitis pigmentosa. Ten patients with autosomal recessive retinitis pigmentosa were tissue typed for class I and II HLA antigens. The results of the study show a significant increase in the frequency of the antigens Cw4, Cw6 and DR11. High values of relative risk were found also for some class I antigens, but the size of the group of patients with these loci precluded a meaningful statistical analysis.
Castagna
I
I
Institute of Ophthalmology, University of Messina, Italy.
Famà
F
F
Pettinato
G
G
Palamara
F
F
Trombetta
C J
CJ
D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D003627:Data Interpretation, Statistical; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D008297:Male; D008858:Microscopy, Phase-Contrast; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors
D015415:Biomarkers; D006680:HLA Antigens