[Effects of (-) SPD and (-) THP on the firing of noradrenergic neurons in locus coeruleus].
The effects of (-) SPD and (-) THP on the noradrenergic neurons in rat locus coeruleus were investigated by recording the in vivo spontaneous firing. It was found that (-) SPD could increase the firing frequency of the NE neurons via antagonistic action on alpha 2 autoreceptors in a dose-dependent manner, while alpha 2 receptor agonist clonidine exerted an inhibitory effect. (-) THP induced inhibitory firing of the neurons, however, irreversible.
Wu
J H
JH
Shanghaai Institute of Materia Medica, Chinese Academy of Sciences.
Jin
G Z
GZ
D018663:Adrenergic Agents / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000494:pharmacology*; D004594:Electrophysiology; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
D018663:Adrenergic Agents; D000317:Adrenergic alpha-Antagonists; D001600:Berberine Alkaloids; D011942:Receptors, Adrenergic, alpha; D001599:Berberine; C010513:stepholidine; C014215:tetrahydropalmatine; D009638:Norepinephrine