title: Human plasma DSIP decreases at the initiation of sleep at different circadian times.
abstract: Nocturnal plasma delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) was determined serially in seven healthy male subjects. Time courses during nocturnal sleep (2300-0800 h), nocturnal sleep deprivation (2300-0500 h), and morning recovery sleep (0500-0800 h) after sleep deprivation were compared. A significant decrease in plasma DSIP-LI was found at the transition from wakefulness to sleep in both evening sleep (2300 h) and morning recovery sleep (0500 h). Time courses were accompanied by physiological changes in sleep electroencephalographic slow-wave activity, and in plasma concentrations of cortisol and human growth hormone. No sleep stage specificity was found. It is concluded that DSIP is influenced by the initiation of sleep.
authors: Depression Research Unit, Psychiatric University Hospital, Basel, Switzerland.
authors: E
authors: E
authors: Seifritz
authors: M J
authors: MJ
authors: Müller
authors: G A
authors: GA
authors: Schönenberger
authors: L
authors: L
authors: Trachsel
authors: U
authors: U
authors: Hemmeter
authors: M
authors: M
authors: Hatzinger
authors: A
authors: A
authors: Ernst
authors: P
authors: P
authors: Moore
authors: E
authors: E
authors: Holsboer-Trachsler
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D003701:Delta Sleep-Inducing Peptide / Q000097:blood*; D004569:Electroencephalography; D013006:Growth Hormone / Q000097:blood; D006706:Homeostasis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology
chemical_list: D003701:Delta Sleep-Inducing Peptide; D013006:Growth Hormone; D006854:Hydrocortisone