title: Effect of intratympanically administered gentamicin on hearing and tinnitus in Menière's disease.
abstract: We have examined the effect of intratympanic gentamicin on hearing and tinnitus in 69 patients with intractable Menière's disease. Tinnitus was scored from 1 to 4 depending on its severity. The mean pure tone audiometry level before treatment was 57.5 dB and 1 year after treatment 63.5 dB Five subjects became deaf in the treated ear, and in 13 subjects hearing loss was > 10 dB and in 21 subjects 0 10 dB. In 25 subjects significant improvement (> 10 dB) was gained, and in 5 patients. Tinnitus was significantly reduced after treatment with gentamicin. A total of 66 patients had tinnitus before treatment and tinnitus relief was rated as good. Four percent of the subjects had no tinnitus, 30% had slight tinnitus. 27% moderate tinnitus. 18% severe and 8% handicapping tinnitus.
authors: Department of Otolaryngology, University of Helsinki, Finland.
authors: S
authors: S
authors: Kaasinen
authors: I
authors: I
authors: Pyykkö
authors: H
authors: H
authors: Ishizaki
authors: H
authors: H
authors: Aalto
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects*; D004432:Ear, Middle / Q000187:drug effects; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D010897:Pitch Discrimination / Q000187:drug effects; D013067:Speech Perception / Q000187:drug effects; D014012:Tinnitus / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins