[Influences of early enteral feeding enriched with glutamine on the gut blood flow and oxygen consumption in severely burned mini-swines].
In order to investigate the effects of L-glutamine on the gut blood flow and oxygen consumption after burn, 14 mini-swines were randomly and equally divided into Non-Gln group and Gln group (which was supplied with L-glutamine, 0.64 g/kg day). Gut blood flow and oxygen consumption were continuously determined from preburn to PBD 10. The results showed that portal venous blood flow (Fpv) and oxygen consumption decreased markedly in all animals, especially the Non-Gln group (P < 0.01), on PBD 4 to PBD 10, when Fpv and oxygen consumption returned to preburn level in Gln group and remained low in Non-Gln group. The portal venous MDA concentration was significantly higher in Non-Gln group than that of Gln group. The results suggest that early enteral feeding enriched with glutamine increases the intestinal blood flow, and decreases the intestinal hypoxemia and reperfusion injury.
Yu
B
B
Institute of Burn Research Southwestern Hospital, Third Military Medical College, Chongqing.
Wang
S
S
You
Z
Z
D000818:Animals; D002056:Burns / Q000628:therapy*; D004750:Enteral Nutrition; D005260:Female; D005973:Glutamine / Q000494:pharmacology*; D007082:Ileum / Q000098:blood supply*; D010101:Oxygen Consumption; D011169:Portal Vein / Q000378:metabolism / Q000503:physiopathology; D011897:Random Allocation; D012039:Regional Blood Flow / Q000187:drug effects; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D005973:Glutamine