[Use of biodegradable microspheres in experimental anticancer therapy. Chronopharmacological application].
We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those cisplatin loaded microspheres, some concentration peaks at the best tolerance time. The cancer is than more hit, by the high local anticancer drug concentration, and doses chronomodulations preserve the patient by following his tolerance. The experimentation on cancerous mice show that this technique could lead to great survival increases. Such a protocol might usefuly improve the anticancer therapy.
Milis
G
G
Laboratoire de Cancérologie Expérimentale, Université de Liège, Belgique.
Grandfils
C
C
Flandroy
P
P
Barbason
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002214:Capsules; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000401:mortality; D002940:Circadian Rhythm; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014465:Ultrasonics
D000970:Antineoplastic Agents; D002214:Capsules; D002945:Cisplatin
Utilisation des microsphères biodégradables en thérapie anti-cancéreuse expérimentale. Application chronopharmacologique.