title: The ultrastructure of parapapillary chorioretinal atrophy in eyes with secondary angle closure glaucoma.
abstract: BACKGROUND
  The present study was performed to investigate the ultrastructure of deep retinal layers and choroid corresponding to the parapapillary chorioretinal atrophy in eyes with secondary angle-closure glaucoma.
  
  
  METHODS
  The glaucomatous eyes included two eyes enucleated due to iris ring melanoma with high intraocular pressure and one eye with neovascular glaucoma enucleated due to ocular pain. The control eyes included one eye enucleated due to choroidal malignant melanoma with normal intraocular pressure and one eye enucleated during surgery for supramandibular carcinoma. These eyes were studied with light and electron microscopy.
  
  
  RESULTS
  In the region of parapapillary chorioretinal atrophy of glaucomatous eyes, the retinal pigment epithelial cells showed degenerative changes, such as loss of basal infoldings and microvilli, degenerated mitochondria, vacuolar degeneration and irregular distribution of melanin granules. The photoreceptors were decreased in number in this area of glaucomatous eyes. The lumen of the choriocapillary vessels adjacent to the optic nerve was collapsed.
  
  
  CONCLUSIONS
  These results elucidate the fine structures of deep retina and choroid in the region of parapapillary chorioretinal atrophy of glaucomatous eyes, and suggest that the reduced choroidal perfusion might be the pathogenetic mechanism of glaucomatous parapapillary chorioretinal atrophy.
authors: Department of Ophthalmology, University Erlangen-Nürnberg, Germany.
authors: T
authors: T
authors: Kubota
authors: U M
authors: UM
authors: Schlötzer-Schrehardt
authors: G O
authors: GO
authors: Naumann
authors: T
authors: T
authors: Kohno
authors: H
authors: H
authors: Inomata
mesh_terms: D000328:Adult; D001284:Atrophy / Q000473:pathology; D002829:Choroid / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology / Q000648:ultrastructure*; D010786:Photoreceptor Cells / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D012160:Retina / Q000473:pathology / Q000648:ultrastructure*