Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression.
The influx of calcium into the postsynaptic neuron is likely to be an important event in memory formation. Among the mechanisms that nerve cells may use to alter the time course or size of a spike of intracellular calcium are cytosolic calcium binding or "buffering" proteins. To consider the role in memory formation of one of these proteins, calbindin D28K, which is abundant in many neurons, including the CA1 pyramidal cells of the hippocampus, transgenic mice deficient in calbindin D28K have been created. These mice show selective impairments in spatial learning paradigms and fail to maintain long-term potentiation. These results suggest a role for calbindin D28K protein in temporally extending a neuronal calcium signal, allowing the activation of calcium-dependent intracellular signaling pathways underlying memory function.
Molinari
S
S
Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, Universita di Modena, Italy.
Battini
R
R
Ferrari
S
S
Pozzi
L
L
Killcross
A S
AS
Robbins
T W
TW
Jouvenceau
A
A
Billard
J M
JM
Dutar
P
P
Lamour
Y
Y
Baker
W A
WA
Cox
H
H
Emson
P C
PC
D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D016373:DNA, Antisense; D018076:DNA, Complementary; D004192:Discrimination, Psychological; D004558:Electric Stimulation; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D018782:Maze Learning; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology
C576499:Calb1 protein, mouse; D064092:Calbindin 1; D064026:Calbindins; D016373:DNA, Antisense; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G