title: Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.
authors: Drug Discovery, R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA.
authors: M J
authors: MJ
authors: Costanzo
authors: B E
authors: BE
authors: Maryanoff
authors: L R
authors: LR
authors: Hecker
authors: M R
authors: MR
authors: Schott
authors: S C
authors: SC
authors: Yabut
authors: H C
authors: HC
authors: Zhang
authors: P
authors: P
authors: Andrade-Gordon
authors: J A
authors: JA
authors: Kauffman
authors: J M
authors: JM
authors: Lewis
authors: R
authors: R
authors: Krishnan
authors: A
authors: A
authors: Tulinsky
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives; D001665:Binding Sites; D002417:Cattle; D018360:Crystallography, X-Ray; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010875:Pipecolic Acids / Q000494:pharmacology; D011485:Protein Binding; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry; D014361:Trypsin Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D006146:Guanidines; D009842:Oligopeptides; D010455:Peptides; D010875:Pipecolic Acids; C100912:RWJ 50353; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; D013844:Thiazoles; D014361:Trypsin Inhibitors; D001120:Arginine; D013917:Thrombin; C031942:argatroban; C064289:efegatran