Cefaclor concentration in pus from abscess caused by odontogenic infection after a single oral administration.
1. Cefaclor concentrations in serum and pus from abscess of odontogenic infection after a single oral administration of 500-mg cefaclor were assayed and pus concentrations were compared with minimum inhibitory concentration (MIC) of oral streptococci isolated from odontogenic infection. 2. The mean peak concentrations in serum and pus were found at identical times, 1.5 hr after administration, which were 7.22 and 0.72 micrograms/ml, respectively. 3. The mean ratio of pus:serum concentration at the peak time was 0.10. 4. Most cefaclor concentrations in pus at the peak time (seven of nine cases) exceeded the MIC for 90% of oral streptococci (0.5 micrograms/ml).
Akimoto
Y
Y
Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Nishimura
H
H
Omata
H
H
Shibutani
J
J
Kaneko
K
K
Kawana
T
T
Kaneda
T
T
Yamamoto
H
H
Fujii
A
A
D000284:Administration, Oral; D000328:Adult; D002433:Cefaclor / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010508:Periodontal Abscess / Q000378:metabolism*; D013492:Suppuration / Q000188:drug therapy / Q000378:metabolism*
D002511:Cephalosporins; D002433:Cefaclor