HLA DRB1*DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis.
A possible causal association between infective dermatitis and HTLV-I infection was reported in 1990 and confirmed in 1992. We now report familial infective dermatitis (ID) occurring in a 26-year-old mother and her 9-year-old son. The mother was first diagnosed with ID in 1969 at the age of 2 years in the Dermatology Unit at the University Hospital of the West Indies (U.H.W.I.) in Jamaica. The elder of her 2 sons was diagnosed with ID at the age of 3 years, also at U.H.W.I. Both mother and son are HTLV-I-seropositive. A second, younger son, currently age 2 years, is also HTLV-I-seropositive, but without clinical evidence of ID. Major histocompatibility complex (MHC), class II, human leucocyte antigen (HLA) genotyping documented a shared class II haplotype, DRB1*DQB1* (1101-0301), in the mother and her 2 sons. This same haplotype has been described among Japanese patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and has been associated with a possible pathologically heightened immune response to HTLV-I infection. The presence of this haplotype in these familial ID cases with clinical signs of HAM/TSP may have contributed to their risk for development of HAM/TSP. The unaffected, HTLV-I-seropositive younger son requires close clinical follow-up.
LaGrenade
L
L
Department of Medicine, Child Health, and Pathology, University of the West Indies, Mona, Jamaica.
Sonoda
S
S
Miller
W
W
Pate
E
E
Rodgers-Johnson
P
P
Hanchard
B
B
Cranston
B
B
Fujiyoshi
T
T
Yashiki
S
S
Blank
M
M
Gibbs
C J
CJ
Manns
A
A
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003872:Dermatitis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D015490:HTLV-I Infections / Q000150:complications / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007563:Jamaica; D008297:Male; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology / Q000276:immunology*; D010375:Pedigree; D011237:Predictive Value of Tests; D012874:Skin Diseases, Infectious / Q000209:etiology* / Q000235:genetics / Q000276:immunology
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains