Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion.
The effect of anti-inflammatory treatment on monocyte/macrophage infiltration, major histocompatibility complex molecules (MHC) class II expression and delayed oedema following experimental brain contusion was studied by immunohistochemistry and tissue-specific gravity measurement in 44 rats. Colchicine, chloroquine and dexamethasone administered once daily for five days after the trauma reduced inflammation and oedema. The difference was statistically significant with colchicine and dexamethasone. The findings comprise further evidence of a pathogenetically important inflammation after experimental contusion. It is probable that anti-inflammatory agents may prevent secondary neurological damage due to elevated intracranial pressure and cell to cell- or cytokine-mediated neuronal degeneration and demyelination.
Holmin
S
S
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Mathiesen
T
T
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001924:Brain Concussion / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000473:pathology; D001929:Brain Edema / Q000473:pathology*; D002738:Chloroquine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004660:Encephalitis / Q000473:pathology*; D005260:Female; D006074:Gout Suppressants / Q000494:pharmacology*; D007124:Immunoenzyme Techniques; D009410:Nerve Degeneration / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000893:Anti-Inflammatory Agents; D006074:Gout Suppressants; D003907:Dexamethasone; D002738:Chloroquine; D003078:Colchicine