[Risk of malignant changes in hydatidiform mole complicated with pregnancy induced hypertension].
OBJECTIVE
To investigate the prognosis of patients of hydatidiform mole (HM) who complicated with pregnancy induced hypertension (PIH) and to suggest that PIH may serve as a risk factor for malignant change in molar pregnancy.


METHODS
From 1962 to 1992, 161 patients of HM including 33 cases with PIH and 128 cases of normotension were managed and followed at the PLA General Hospital. The definition of malignant sequelae was that abnormal hCG level was lasting at least 8 weeks after molar evacuation or metastatic lesions was found.


RESULTS
15 of 33 patients with PIH developed metastatic invasive moles (45.5%) and 13 of them metastatic tumors were found before molar evacuation. 12 of 128 cases of normotension had malignant thanges including 1 choriocarcinoma and 11 invasive mole (9.4%) and among them only one had metastatic lesions before molar evacuation.


CONCLUSIONS
The incidence (45.5%) of malignant changes in patients complicated with PIH was significantly higher than that in normotensive patients (9.4%) (P < 0.01). In addition, they had early metastatic lesions. This study suggests that PIH may serve as a risk factor for malignant change in molar pregnancy.
Zhao
X
X
PLA General Hospital, Beijing.
Guan
Z
Z
D000328:Adult; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications* / Q000473:pathology; D002820:Hydatidiform Mole, Invasive / Q000150:complications / Q000473:pathology; D011225:Pre-Eclampsia / Q000150:complications*; D011247:Pregnancy; D012307:Risk Factors