Peripherally administered calcitonin gene-related peptide decreases food intake in mice.
Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats. Amylin, which has a close structural homology to CGRP, reduced food intake administered IP at concentrations higher than those previously tested for CGRP. We examined the effects of higher doses of IP-administered CGRP on food intake. CGRP reduced food intake from 25 to 200 micrograms/kg in mice. CGRP did not reduce water intake and was not aversive in a two-bottle test. Using a lever press, CGRP was more effective at reducing milk consumption in prefed than in nonprefed mice. The effect of CGRP on food intake was not antagonized by the cholecystokinin A receptor antagonist, L364,718. These studies suggest a role for CGRP as a satiating factor.
Morley
J E
JE
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, St. Louis, MO 63106, USA.
Farr
S A
SA
Flood
J F
JF
D000704:Analysis of Variance; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D020109:Devazepide; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation; D006579:Heterozygote; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008820:Mice, Obese; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000819:agonists; D012054:Reinforcement, Psychology; D014868:Water Deprivation
D001570:Benzodiazepinones; D006727:Hormone Antagonists; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D020109:Devazepide; D015740:Calcitonin Gene-Related Peptide