[Inhibition of apoptosis by a baculovirus p35 gene].
The baculovirus gene p35 inhibits virus-induced apoptosis in insect cells. p35 can also inhibit developmentally programmed cell death in Caenorhabditis elegans and Drosophila, mammalian neuronal cell death induced by serum or NGF deprivation, and Fas- and tumor necrosis factor (TNF)-induced apoptosis in mammalian cells, indicating that p35 may interrupt an evolutionally conserved component of the death machinery. Recently it has been shown that p35 protein functions as an inhibitor of ICE/CED-3 cysteine protease family that seem to play an important role in an apoptotic pathway. This observation indicates that p35 may inhibit apoptosis by directly blocking the activities of these cysteine proteases in diverse animals.
Ohtsubo
T
T
Biotech. Lab., Sumitomo Chemical Co., LTD.
Kamada
S
S
Tsujimoto
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D016367:Baculoviridae / Q000235:genetics*; D001483:Base Sequence; D015853:Cysteine Proteinase Inhibitors; D005814:Genes, Viral / Q000502:physiology; D008969:Molecular Sequence Data; D014764:Viral Proteins / Q000502:physiology
D015853:Cysteine Proteinase Inhibitors; D014764:Viral Proteins