Serum antioxidant potential, and lipoprotein oxidation in female smokers following vitamin C supplementation.
A single blind placebo controlled trial was carried out to assess the effect of high dose vitamin C supplementation on the antioxidant potential, and extent of lipoprotein oxidation of serum in female smokers. Sixteen apparently healthy subjects were randomised into two groups of eight. One group received 1 g of vitamin C for 14 days the other group received a placebo for 14 days. Serum antioxidant potential (TRAP) was measured and lipoprotein oxidation was assessed by measuring serum malondialdehyde like material. Despite significant increases in serum C concentrations in the supplemented group, serum TRAP values did not change significantly over the course of the trial. Serum malondialdehyde like material also failed to show any temporal variation.
Mulholland
C W
CW
Health and Health Care Research Unit, School of Clinical Medicine, Queens University, Royal Victorial Hospital, Belfast, UK.
Strain
J J
JJ
Trinick
T R
TR
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects / Q000097:blood*
D000975:Antioxidants; D008315:Malondialdehyde; D001205:Ascorbic Acid