[Effect of pentagastrin on the survival of allogenic grafts from fetal rat intestine].
OBJECTIVE
Pentagastrin is not known as an immunomodulatoring drug. The aims of the present study were to create an optimal schedule for pentagastrin administration and to evaluate its influence on the allogenic foetal intestinal graft survival and the recipient condition in rats.


METHODS
An allogenic foetal intestinal graft was performed in rats treated by pentagastrin 1 mg/kg/day and in controls. Biomorphometry and histology of the graft was regularly studied and biochemical, hematological, immunological and morphological parameters were determined in a maximal observation time of 19.5 months.


RESULTS
Pentagastrin treatment, 1 mg/kg/day, significantly increased the graft survival in rats and. In 50% of the cases, tolerance was reached without any damage for the recipients. This may be due to additional effects of mild immunodepressive and trophic influences of pentagastrin, which have to be confirmed and which could be useful in adult intestine transplantation.
Coulic
V
V
Faculté de Médecine de l'Université de l'Amitié des Peuples, Moscou, Russie.
Iskrenko
I
I
Krivsky
I
I
Roubtsova
E
E
D000818:Animals; D001699:Biometry; D001808:Blood Vessels / Q000502:physiology; D004423:Ear / Q000098:blood supply; D016332:Fetal Tissue Transplantation / Q000379:methods*; D006085:Graft Survival / Q000187:drug effects* / Q000276:immunology; D007108:Immune Tolerance; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000637:transplantation*; D051379:Mice; D010418:Pentagastrin / Q000494:pharmacology*; D051381:Rats; D014184:Transplantation, Homologous
D010418:Pentagastrin
Influence de la pentagastrine sur la survie des greffons allogéniques d'intestin foetal chez le rat.