Presentation of antigen by B cell subsets. V. Effect of interleukin 7 (IL-7) and interleukin 10 (IL-10) on phenotype and antigen presenting function of immature B cells.
In this communication we demonstrate that B cells from CBA/N mice with x chromosome-linked immunodeficiency and B cells from newborn mice, that have very limited ability to present antigen to antigen-specific T cells lines, acquire this function following preincubation with IL-7 or IL-10. These interleukins do not affect the antigen presenting function of B cells from normal, adult CBA mice. Incubation of B cells from xid and newborn mice with IL-7 or IL-10 but not with IL-2 induces expression of Lyb-5 marker on these cells. The study shows that the property of IL-7 and IL-10 to induce antigen presenting cell (APC) activity in immature B cells is associated with appearance of Lyb-5 antigen on these cells.
Zimecki
M
M
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Kapp
J A
JA
D000818:Animals; D000831:Animals, Newborn; D017951:Antigen Presentation / Q000187:drug effects*; D000950:Antigens, Ly / Q000096:biosynthesis; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002460:Cell Line; D005260:Female; D016130:Immunophenotyping; D016753:Interleukin-10 / Q000494:pharmacology*; D015851:Interleukin-7 / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D000950:Antigens, Ly; D015851:Interleukin-7; D016753:Interleukin-10