title: Neurosteroid modulation of native and recombinant GABAA receptors.
abstract: 1. The pioneering work of Hans Selye over 50 years ago demonstrated that certain steroid metabolites can produce a rapid depression of central nervous system activity. 2. Research during the last 10 years has established that such effects are mediated by a nongenomic and specific interaction of these steroids with the brain's major inhibitory receptor, the GABAA receptor. 3. Here we describe the molecular mechanism of action of such steroids and review attempts to define the steroid binding site on the receptor protein. The therapeutic potential of such neurosteroids is discussed.
authors: Department of Pharmacology & Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Scotland.
authors: J J
authors: JJ
authors: Lambert
authors: D
authors: D
authors: Belelli
authors: C
authors: C
authors: Hill-Venning
authors: H
authors: H
authors: Callachan
authors: J A
authors: JA
authors: Peters
mesh_terms: D000818:Animals; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013256:Steroids / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D011963:Receptors, GABA-A; D011994:Recombinant Proteins; D013256:Steroids