[The injury of liver and kidney of rats sustaining delayed fluid resuscitation of burn shock].
Delayed fluid resuscitation of burn shock may lead to many harmful effects. We investigated the injury of liver and kidney of rats sustaining non-fluid perfusion, immediate perfusion, and delayed perfusion of burn shock. The electron spin reonance (ESR) was used to determine the existence of oxygen free radicals (OFR) successfully. We tested the activity of ATP enzyme in kidney, lactate dehydrogenase isoenzyme 5 (LDH5), GPT and GOT. We also tested the contents of malonaldehyde (MDA) and ATP in liver and kidney, urea nitrogen (BUN) and creatinine (Cr) in blood. We found that OFR plays an important role in the injury of liver and kidney sustaining delayed fluid resuscitation of burn shock. Immediate fluid perfusion can not protect the liver and kidney perfectely. And some OFR scavengers should be added to the fluid resuscitation of burn shock.
Lu
W
W
Burn Institute, Changhai Hospital, Shanghai.
Chen
Y
Y
Chen
C
C
D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000628:therapy; D005440:Fluid Therapy; D007668:Kidney / Q000293:injuries*; D008099:Liver / Q000293:injuries*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000378:metabolism* / Q000628:therapy; D013997:Time Factors