title: Thymulin reduces hyperalgesia induced by peripheral endotoxin injection in rats and mice.
abstract: In a new model of peripheral localized inflammation, induced by intraplantar endotoxin (1.25 micrograms) injection in the hind paw of rats and mice, thymulin, a hormone of the thymus gland involved in immunomodulation, reduced inflammatory pain. High doses of thymulin reduced significantly, and in a dose-dependent manner, mechanical hyperalgesia as assessed by the paw pressure test and thermal hyperalgesia as assessed by the hot plate test and tail immersion test.
authors: Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon. bared@layla.aub.ac.lb
authors: B
authors: B
authors: Safieh-Garabedian
authors: R H
authors: RH
authors: Jalakhian
authors: N E
authors: NE
authors: Saadé
authors: J J
authors: JJ
authors: Haddad
authors: S J
authors: SJ
authors: Jabbur
authors: S A
authors: SA
authors: Kanaan
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000009:adverse effects*; D005684:Gait / Q000187:drug effects; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D013935:Thymic Factor, Circulating / Q000494:pharmacology*
chemical_list: D004731:Endotoxins; D013935:Thymic Factor, Circulating