title: Acute hypoxic pulmonary vascular response does not accompany plasma endothelin-1 elevation in subjects susceptible to high altitude pulmonary edema.
abstract: We have previously shown that high altitude pulmonary edema-susceptible subjects (HAPE-S) have an accentuated pulmonary vascular response to hypoxia. In this study, we investigated the relationship between plasma endothelin-1 (ET-1) levels and the acute hypoxic pulmonary vascular response in HAPE-S and control subjects. In six HAPE-S and seven healthy subjects, we evaluated acceleration time/right ventricular ejection time (AcT/RVET) using Doppler echocardiography, and measured plasma ET-1 levels by radioimmunoassay (RIA) before and after 5 minutes of breathing 10% oxygen. The HAPE-S showed a significantly increased pulmonary vascular response to hypoxia compared with healthy subjects. However, no statistically significant changes of plasma ET-1 levels were observed before and after hypoxia in both groups. We conclude that the increased pulmonary vascular response to acute hypoxia in HAPE-S may not be related to ET-1 release.
authors: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.
authors: Y
authors: Y
authors: Droma
authors: R L
authors: RL
authors: Ge
authors: M
authors: M
authors: Tanaka
authors: T
authors: T
authors: Koizumi
authors: M
authors: M
authors: Hanaoka
authors: T
authors: T
authors: Miyahara
authors: S
authors: S
authors: Yamaguchi
authors: K
authors: K
authors: Okada
authors: S
authors: S
authors: Yoshikawa
authors: K
authors: K
authors: Fujimoto
authors: Y
authors: Y
authors: Matsuzawa
authors: K
authors: K
authors: Kubo
authors: T
authors: T
authors: Kobayashi
authors: M
authors: M
authors: Sekiguchi
mesh_terms: D000208:Acute Disease; D000328:Adult; D000532:Altitude Sickness / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000502:physiology*; D011654:Pulmonary Edema / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
chemical_list: D019332:Endothelin-1