title: Stability of therapeutic drug measurement in specimens collected in VACUTAINER plastic blood-collection tubes.
abstract: Recently Becton-Dickinson marketed a plastic serum-separator tube that uses the same serum-separator gel as the glass tubes. We studied the stability of therapeutic drugs stored in plastic tubes by comparing it with the stability of drugs stored in glass serum-separator tubes and plain red-top glass tubes. We observed no absorption of caffeine, primidone, N-acetylprocainamide, procainamide, theophylline, tobramycin, ethosuximide, acetaminophen, amikacin, valproic acid, methotrexate, salicylate, and cyclosporine in either plastic or glass serum-separator tubes. On the other hand, concentrations of lidocaine, quinidine, phenobarbital, and phenytoin were reduced after storing in both plastic and glass serum-separator tubes, especially with prolonged storage and small sample volume. The reduction in concentrations were due to slow absorption of those drugs by serum-separator gel.
authors: Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque 87106, USA.
authors: A
authors: A
authors: Dasgupta
authors: W
authors: W
authors: Blackwell
authors: D
authors: D
authors: Bard
mesh_terms: D001800:Blood Specimen Collection / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism; D010969:Plastics
chemical_list: D004364:Pharmaceutical Preparations; D010969:Plastics