[Molecular biology in cerebral gliomas: recent advances].
Meanwhile first gene therapy assays in cerebral gliomas are in progress, we present in this article a review of the major genetic aberrations reported to date in these tumors. The analysis of these alterations enabled, these last few years, significative advances in the understanding of the mechanisms involved in glioma tumorigenesis. It is now well recognized that tumors result from a multistep process requiring in particular proto-oncogenes activation and tumor suppressor genes inactivation. The different genes implicated in the development of gliomas, their place in the tumoral progression and their potential therapeutic relevance are detailed in this review. The continuation of the identification of glioma altered genes is essential to provide new diagnostic and pronostic markers, and specific targets for more efficient therapy.
Hoang-Xuan
K
K
Service de Neurologie, Hôpital de la Salpêtrière, Paris.
Li
Y J
YJ
Hamelin
R
R
Delattre
O
O
D001932:Brain Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology
Biologie moléculaire des gliomes cérébraux: progrès récents.