Adenosine-sensitive ventricular tachycardia: a conceptual approach.
Idiopathic ventricular tachycardia (VT) is a term that refers to tachycardia that arises from ventricles devoid of apparent structural abnormalities. This form of VT is now recognized to be related to several distinct entities and includes a reentrant form typically located in the region of the left posterior fascicle, an automatic form that may originate from either ventricle, and a form that originates from the right ventricular outflow tract. This last type can account for up to 80% of cases of idiopathic VT and with few exceptions can be further subdivided into repetitive monomorphic VT and paroxysmal stress-induced VT. Evidence has accumulated suggesting that both forms of VT are related to cAMP-mediated triggered activity. The experimental underpinnings of this conclusion as well as the clinical characteristics of this form of idiopathic VT are elucidated in this review.
Lerman
B B
BB
Department of Medicine, New York Hospital-Cornell University Medical Center, New York 10021, USA.
Stein
K M
KM
Markowitz
S M
SM
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D004562:Electrocardiography; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D017180:Tachycardia, Ventricular / Q000139:chemically induced / Q000503:physiopathology*
D000241:Adenosine