[Study on the effect and mechanism of qinggan xiehuo decoction in treatment of endotoxin-induced uveitis in rabbits].
The therapeutic efficacy of Qinggan Xiehuo Decoction (QGXHD) on rabbit model of uveitis (1) The symptoms of Liver-Fire such as conjunctival congestion, thirsty dark urine, oliguria, irritability and rapid pulse were markedly relieved (P < 0.05-0.01); (2) The ophthalmic signs, iris hyperemia and aqueous humor turbidity observed through slit-lamp were improved significantly (P < 0.01); (3) The inflammatory infiltration, the protein content and leukocyte count in the aqueous humor decreased markedly (P < 0.01); (4) The concentration of inflammatory mediators in blood and aqueous humor were reduced. (5) Pathological examination showed that the QGXHD could protect the capillary, blood-aqueous barrier and alleviated the uveal damage caused by endotoxin.
Zhang
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Institute of Integrated Medicine of TCM-WM, Hunan Medical University, Changsha.
Li
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Li
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D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D018916:Blood-Aqueous Barrier; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004731:Endotoxins; D017997:Leukotriene C4 / Q000378:metabolism; D008297:Male; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D017997:Leukotriene C4