Genetics and molecular biology of hepatic lipase.
Hepatic lipase is emerging as a major factor in the control of HDL metabolism. Hepatic lipase plays a central role in the hydrolysis of HDL2 triglycerides and phospholipids and in the concomitant apolipoprotein A-I efflux from this density class. New data suggest that allelic variation at the hepatic lipase gene locus accounts for 25% of the total variability in HDL cholesterol. Recent information suggests that this lipase may enhance the uptake of lipoproteins by cell surface receptors.
Bensadoun
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Division of Biological Sciences, Cornell University, Ithaca, NY 14853-6301, USA.
Berryman
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D000818:Animals; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D007009:Hypolipoproteinemias; D008049:Lipase / Q000235:genetics* / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis
D008075:Lipoproteins, HDL; D012333:RNA, Messenger; D008049:Lipase