Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined immunodeficiency.
We report an infant with severe combined immunodeficiency (SCID) who had cutaneous manifestations of acute graft-versus-host disease (GVHD) due to maternofetal lymphocyte engraftment. Histologic and ultrastructural examinations of the skin revealed intracellular vacuoles resembling lipid droplets in the epidermis and dermis, which is not a recognized feature of acute GVHD or SCID.
Farrell
A
A
Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
Scerri
L
L
Stevens
A
A
Millard
L G
LG
D000208:Acute Disease; D003873:Dermatitis, Exfoliative / Q000150:complications / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D007223:Infant; D015603:Keratinocytes / Q000648:ultrastructure*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D016511:Severe Combined Immunodeficiency / Q000150:complications*; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology; D014617:Vacuoles / Q000648:ultrastructure