An overdose of risperidone.
A fatality resulting from the suicidal ingestion of risperidone is described. The decedent had a lengthy history of mental illness but was otherwise healthy. Biological fluid samples obtained at autopsy were analyzed for risperidone by high-performance liquid chromatography. The blood concentration of risperidone was 1.8 mg/L, the urine concentration was 14.4 mg/L, and the concentration in the gastric contents was 34.6 mg/L (1.04 mg total). The 9-hydroxy-risperidone metabolite was not detected in the blood or gastric contents; however, the urine contained 17.8 mg/L of this metabolite.
Springfield
A C
AC
Institute of Forensic Medicine, University of North Texas Health Science Center, Fort Worth, USA.
Bodiford
E
E
D014150:Antipsychotic Agents / Q000097:blood / Q000506:poisoning* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D007555:Isoxazoles / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D000068882:Paliperidone Palmitate; D011743:Pyrimidines / Q000097:blood / Q000652:urine; D012015:Reference Standards; D018967:Risperidone / Q000097:blood / Q000506:poisoning* / Q000652:urine; D013405:Suicide
D014150:Antipsychotic Agents; D007555:Isoxazoles; D011743:Pyrimidines; D018967:Risperidone; D000068882:Paliperidone Palmitate