Antidepressants in the treatment of premature ejaculation.
The SSRI antidepressants have emerged as effective new treatment for patients with premature ejaculation whether or not these patients suffer from depression. Clomipramine, fluoxetine, paroxetine, and sertraline seem to be a safe treatment option for patients with premature ejaculation, especially in cases of failed psychological treatment, in rejection of psychological treatment, and when partners are unwilling to cooperate in treatment. Further controlled and larger studies that focus on clinically relevant issues such as dose, length of treatment, maintenance of beneficial effects after treatment discontinuation, and the combination of pharmaco- and behavior therapy for premature ejaculation are warranted. Other medications, such as benzodiazepines, may be useful in some cases of premature ejaculation.
Balon
R
R
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004542:Ejaculation; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D011613:Psychotherapy; D020280:Sertraline; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000628:therapy
D000928:Antidepressive Agents; D005473:Fluoxetine; D017374:Paroxetine; D015057:1-Naphthylamine; D002997:Clomipramine; D020280:Sertraline