Contraception with anti-progesterone.
Anti-progesterones have potential as contraceptives, acting either by the inhibition of ovulation or the inhibition of endometrial development. Clinical studies have shown that once-a-month treatment with Mifepristone in the early luteal phase is an effective contraceptive method, and that emergency post-coital contraception with Mifepristone is at least as effective as other methods currently used. Recent studies indicate that the endometrium is more susceptible to Mifepristone than are the hypothalamic and pituitary regions, and it may therefore be possible to develop a new contraceptive method based on low daily or once-weekly doses of Mifepristone that does not influence ovarian function.
Swahn
M L
ML
Department of Obstetrics & Gynaecology, Karolinska Hospital, Stockholm, Seden.
Danielsson
K G
KG
Bygdeman
M
M
D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D015735:Mifepristone / Q000494:pharmacology*
D003271:Contraceptive Agents, Female; D006727:Hormone Antagonists; D015735:Mifepristone