[Criterion quality and estimation of the expected sample size in sequential analysis of linkage].
It is shown that, when conducting sequential testing of linkage in pedigree samples, (1) type I and type II errors observed are less than expected and (2) the generally accepted method for determining the average sample size, E(N), required for sequential analysis of linkage, underestimates it. A less biased approximation of E(N) is proposed. A wide scattering of actual sample sizes required for completion of sequential analysis is demonstrated, which puts practical use of E(N) into question.
Aksenovich
T I
TI
Filimonov
A V
AV
Persova
T B
TB
D005069:Evaluation Studies as Topic; D008040:Genetic Linkage; D006801:Humans; D016014:Linear Models; D008957:Models, Genetic; D015233:Models, Statistical; D010375:Pedigree; D015203:Reproducibility of Results; D018401:Sample Size; D017422:Sequence Analysis, DNA / Q000379:methods*
Kachestvo kriteriia i otsenka ozhidaemogo razmera vyborki pri posledovatel'nom analize stsepleniia.