Molecular biology of phospholipid transfer protein.
Lipid transfer proteins play an essential role in the intravascular dynamics of lipids among lipoproteins and between lipoproteins and cell membranes. Phospholipid transfer protein has been known for over a decade but, unlike cholesteryl ester transfer protein, has been investigated relatively little with regard to its physiological importance. The recent determination of the phospholipid transfer protein complementary DNA sequence as well as the further characterization of its gene structure will direct future studies toward the understanding of its structure-function correlations, physiological regulation, and clinical assessment at the molecular level. As a member of the lipid-transfer lipopolysaccharide-binding protein gene family, phospholipid transfer protein will attract investigators to studying its possible involvement in lipopolysaccharide or endotoxin interactions in addition to its phospholipid transfer activity.
Albers
J J
JJ
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98103-9103, USA.
Tu
A Y
AY
Wolfbauer
G
G
Cheung
M C
MC
Marcovina
S M
SM
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D005810:Multigene Family; D049294:Phospholipid Transfer Proteins; D011401:Promoter Regions, Genetic; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D013329:Structure-Activity Relationship
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D018950:Lipopolysaccharide Receptors; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins; D011994:Recombinant Proteins; C021623:bactericidal permeability increasing protein