Pharmacokinetics of oral ketorolac in the rat.
The pharmacokinetics of ketorolac, a potent analgesic agent used for relief of moderate to severe pain, has been studied in rats who received oral doses of 1, 3.2 or 5.6 mg/kg of ketorolac tromethamine. Blood samples were obtained at selected times during 24 h after medication, and ketorolac concentrations were determined by high performance liquid chromatography. After administration of ketorolac, blood concentrations increased rapidly reaching a dose-dependent maximal concentration in about 20 min. Then, concentrations decayed with a half-life of about 6 h. A linear increase in Cmax and AUC as a function of the dose was observed, and not statistically significant difference was observed in AUC/dose or Cmax/dose between doses, indicating that pharmacokinetics of ketorolac is linear in the range of doses studied.
Granados-Soto
V
V
Seccion de Terapeutica Experimental, Departamento de Farmacologia y Toxicologia del Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico.
Flores-Murrieta
F J
FJ
D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D000818:Animals; D005260:Female; D020911:Ketorolac Tromethamine; D007661:Ketoses; D051381:Rats; D017208:Rats, Wistar; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014325:Tromethamine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D018712:Analgesics, Non-Narcotic; D007661:Ketoses; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin