Ocular masquerade syndrome in lymphoid blast crisis of chronic myeloid leukemia.
A 56-year-old woman presented with CML in lymphoid blast crisis. Complete remission with no suggestion of CML was achieved with chemotherapy. Twenty-six months later, an isolated ocular anterior chamber relapse of acute leukemia presenting as uveitis (ocular masquerade syndrome) was diagnosed and treated with radiotherapy. Ten months later, a second ocular relapse in the same location was diagnosed and treated with radiotherapy. Two months later, a systemic relapse into second chronic phase was diagnosed and is currently being treated with alpha interferon. Only one previous case of leukemic hypopyon in CML has been reported. This is also the first case of isolated ocular blast crisis relapse in CML to be described.
Lipton
J H
JH
Department of Medicine, University of Toronto, Ontario, Canada.
McGowan
H D
HD
Payne
D G
DG
D001752:Blast Crisis; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005134:Eye Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D012008:Recurrence; D013577:Syndrome; D014605:Uveitis / Q000209:etiology*
D003037:Cobalt Radioisotopes; D016898:Interferon-alpha