[T antigen test of sputum--a new simple method for the screening of lung cancer].
The sputum specimens from 116 healthy persons and 216 cases of benign and malignant lung diseases were detected for T antigen using a strip test by enzyme galactose oxidase-Schiff sequence. The result shows that 165 cases of the 182 patients with lung cancer, confirmed by cytology and histology, had positive results, whereas 22/116 (19.0%) of healthy controls were positive. So the sensitivity was 90.7% and the specificity was 81.0%. In 28 cases of patients whose cytology of sputa showed various degrees of dysplasia, 21 were found T antigen positive, of which 15 patients were identified to be lung cancer in the follow-up study. In addition, three cases of early lung cancer in this study were also positive, suggesting that T antigen was expressed at an earlier stage in the malignant process. The study has indicated that T antigen test of sputum is a sensitive method for the diagnosis of lung cancer. It may also be a promising approach for the massive screening of lung cancer in terms of its rapidity, economy and simplicity.
Li
X
X
Cancer Research Institute, China Medical University, Shenyang.
Dai
X
X
He
A
A
D000230:Adenocarcinoma / Q000175:diagnosis; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D006801:Humans; D007519:Isoantigens / Q000032:analysis; D008175:Lung Neoplasms / Q000175:diagnosis*; D013183:Sputum / Q000276:immunology*
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D007519:Isoantigens; C016467:Thomsen-Friedenreich antigen