Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder.
Chromosome 12q is a region of interest for the genetics of bipolar affective disorder because of reports of apparent cosegregation between this disorder and Darier's disease in a small number of families. Findings from a recent linkage study suggest that this chromosomal region may contain a susceptibility gene for bipolar affective disorder. We have found evidence of an allelic association between bipolar disorder and a marker at the pancreatic phospholipase A2 gene (PLA2A) in this region (p < or = 0.01). These results are consistent with the linkage study, and warrant additional investigations.
Dawson
E
E
Department of Neuroscience and Genetics Section, Institute of Psychiatry, London, UK.
Gill
M
M
Curtis
D
D
Castle
D
D
Hunt
N
N
Murray
R
R
Powell
J
J
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D004247:DNA / Q000097:blood / Q000302:isolation & purification; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D010375:Pedigree; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D016133:Polymerase Chain Reaction; D012016:Reference Values; D012044:Regression Analysis
D005819:Genetic Markers; D004247:DNA; D010741:Phospholipases A; D054467:Phospholipases A2