[The damped torsion swing test in guinea pigs].
The damped torsion swing test (DTST) was carried out for assessing the vestibular function in guinea pigs. Twenty guinea pigs which had normal pinna reflexes and normal tympanic membranes were used. In the formula, L represented the number of the left nystagmus, and R the right nystagmus during DTST. The symmetric rate [formula: see text] between left and right nystagmus was calculated. Then the animals were randomly divided into two groups: (1) Gentamicin group (n = 10): DTST was reexamined, Animals were injected with gentamicin (250 mg/kg) for three days. (2) Endolymphatic hydrops group (n = 10): Surgical obliteration of the right endolymphatic sac and duct was done, 30 days later DTST was carried out again. The results showed: (1) The normal value [formula: see text] of DTST in the 20 healthy guinea pigs is less than 8.25%. (2) Both of left and right nystagmus were reduced (P < 0.01) in gentamicin group. (3) The number of the right nystagmus was reduced in endolymphatic hydrops group (P < 0.01) and the symmetric rate of 6 animals was more than 8.25%. It is concluded that DTST is an important method of evaluating vestibular function in guinea pigs.
Xu
X
X
General Hospital of the Air Force, Beijing.
Fu
G
G
Tan
Z
Z
D000818:Animals; D004584:Electronystagmography; D018159:Endolymphatic Hydrops / Q000503:physiopathology*; D005260:Female; D005839:Gentamicins; D006168:Guinea Pigs; D006199:Hair Cells, Auditory, Inner / Q000473:pathology; D008297:Male; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000473:pathology / Q000503:physiopathology*
D005839:Gentamicins