Cyclic change of cytokines in a patient with cyclic thrombocytopenia.
The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described. Interleukin 7, stem cell factor, and transforming growth factor beta 1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.
Kimura
F
F
Third Department of Internal Medicine, National Defence Medical College, Saitama, Japan.
Nakamura
Y
Y
Sato
K
K
Wakimoto
N
N
Kato
T
T
Tahara
T
T
Yamada
M
M
Nagata
N
N
Motoyoshi
K
K
D000328:Adult; D006801:Humans; D015851:Interleukin-7 / Q000378:metabolism*; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D008297:Male; D010507:Periodicity; D010976:Platelet Count; D019089:Stem Cell Factor / Q000378:metabolism*; D013921:Thrombocytopenia / Q000378:metabolism*; D013926:Thrombopoietin / Q000378:metabolism*
D015851:Interleukin-7; D019089:Stem Cell Factor; D016173:Macrophage Colony-Stimulating Factor; D013926:Thrombopoietin