title: [Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care].
abstract: Treatment of chronic hepatic encephalopathy is difficult. Oral flumazenil has been proposed for long-term treatment but is not presently available on the market. We report the successful treatment of one case of chronic hepatic encephalopathy in cirrhosis without precipitating factors by low dose intravenous injections of flumazenil (Anexate, 1 mg/4 hours). Flumazenil is expensive and not always effective. We suggest reserving this treatment to highly selected patients (without precipitating factor, or after failure of first choice treatment).
authors: Service d'Hépato-Gastroentérologie et de Nutrition, Hôpital de l'Archet, Nice.
authors: J L
authors: JL
authors: Péroux
authors: O
authors: O
authors: Paolini
authors: A
authors: A
authors: Tran
authors: B
authors: B
authors: Frappa
authors: P
authors: P
authors: Rampal
mesh_terms: D000553:Ambulatory Care; D002908:Chronic Disease; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000601:surgery; D005442:Flumazenil / Q000008:administration & dosage / Q000627:therapeutic use*; D018757:GABA Modulators / Q000008:administration & dosage / Q000627:therapeutic use*; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007275:Injections, Intravenous; D008103:Liver Cirrhosis / Q000150:complications*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D012422:Rupture, Spontaneous; D013997:Time Factors
chemical_list: D018757:GABA Modulators; D005442:Flumazenil
vernacular_title: Encéphalopathie hépatique chronique traitée de façon prolongée en ambulatoire par flumazénil intraveineux.