title: Multiple sensory and functional effects of non-phenolic aminodimethylene nonivamide: an approach to capsaicin antagonist.
abstract: 1. Hexylaminodimethylene nonivamide (CAPCNC6, 0.1-10 microM) inhibited the contractility of isolated guinea pig right atria, toxically revealed positive inotropic, chronotropic and then a cardiac arrest effect at 100 microM and inhibited capsaicin (1.0 microM)-induced cardiotonic effects. 2. CAPCNC6 (0.1-10 microM)-induced aorta contractions were inhibited in the presence of flunarizine, atropine, phentolamine, Ca(2+)-free solution and pre-treatment of the animal with capsaicin. 3. CAPCNC6 (1.0-300 microM)-induced trachea contractions were inhibited in the presence of capsazepine, ruthenium red, hCGRP8-37 and pre-treatment of the animal with capsaicin.
authors: Department of Pediatrics, Kaohsiung Medical College, Taiwan, Republic of China.
authors: J R
authors: JR
authors: Wu
authors: S F
authors: SF
authors: Fann
authors: J L
authors: JL
authors: Yeh
authors: Y C
authors: YC
authors: Lo
authors: T Y
authors: TY
authors: Huang
authors: I J
authors: IJ
authors: Chen
mesh_terms: D000577:Amides; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers; D002211:Capsaicin / Q000037:antagonists & inhibitors*; D005260:Female; D005444:Flunarizine / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014132:Trachea / Q000187:drug effects; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000577:Amides; C099762:CAPCNC6; D002121:Calcium Channel Blockers; D014641:Vanillic Acid; D005444:Flunarizine; D002211:Capsaicin