Comparison of the anti-inflammatory effect and gastrointestinal tolerability of aceclofenac and diclofenac.
Aceclofenac (CAS 89796-99-6) and diclofenac (CAS 15307-79-6) are orally effective non-steroidal anti-inflammatory drugs. Their anti-inflammatory and potential gastrointestinal damaging effects were compared following single and repeated administration (5 days). Both drugs exerted an anti-inflammatory activity and showed a similar gastrointestinal tolerability in the rat.
Arañó
A
A
Centro de Investigación y Desarrollo Aplicado, S.A.L., Barcelona, Spain.
Zapatero
M I
MI
Basi
N
N
Duque
A
A
Gropper
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity*; D002351:Carrageenan; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D002351:Carrageenan; C056498:aceclofenac