title: Effects of recombinant human growth hormone treatment in intrauterine growth-retarded preterm newborn infant on growth, body composition and energy expenditure.
abstract: The effects of recombinant human growth hormone treatment during the early postnatal period on growth, body composition and energy expenditure were studied in seven intrauterine growth-retarded newborns. Seven infants were studied as controls. No differences were seen in bodyweight or height gain (15.9 +/- 1.5 g/kg per day and 1.02 +/- 0.24 cm/week in the treated and 16.3 +/- 1.4 g/kg per day and 1.11 +/- 0.30 cm/week in the control group). Skinfold growth rate was 0.52 +/- 0.20 mm/week in the treated vs. 0.56 +/- 0.28 mm/week in the control group. Total body water (as a percentage of bodyweight, 80 +/- 3.0% vs. 80 +/- 4.0%) and energy expenditure (67.5 +/- 7.4 vs. 66.7 +/- 6.4kcal/kg per day) using 2H2 18O showed identical results in both groups. We conclude that the recombinant human growth hormone treatment directly after birth in intrauterine growth-retarded newborn infants results neither in an increase in growth rate nor a change in body composition or energy expenditure during the early postnatal period.
authors: Department of Paediatrics, Hospital of the Vrije Universiteit, Amsterdam, The Netherlands.
authors: L
authors: L
authors: van Toledo-Eppinga
authors: E C
authors: EC
authors: Houdijk
authors: A
authors: A
authors: Cranendonk
authors: H A
authors: HA
authors: Delemarre-Van de Waal
authors: H N
authors: HN
authors: Lafeber
mesh_terms: D000886:Anthropometry; D001724:Birth Weight; D001823:Body Composition / Q000187:drug effects*; D001834:Body Water; D004734:Energy Metabolism / Q000187:drug effects*; D005317:Fetal Growth Retardation / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D005865:Gestational Age; D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011994:Recombinant Proteins / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone