Airborne emissions at skin surfaces: a potential biological exposure index.
Dermal exposures of methanol were administered in a clinical study designed to compare several biological indicators. Four subjects were exposed in five exposure sessions of varying length. In each session, a sequence of measurements of methanol concentrations in blood, breath, and headspace samples of air at exposed and unexposed skin were collected before and after dermal exposures. Skin headspace samples, collected in gas sampling bags, were designed to reflect equilibrium skin: air partitioning. At exposed skin, headspace samples were highly elevated for at least 8 h following exposure, indicating the presence of a methanol reservoir in skin. After exposure, methanol concentrations at exposed skin showed a rapid initial decline, then a slower first-order decrease. Methanol concentrations were clearly detectable in headspace samples at unexposed skin. Substantial transfer from exposed skin occurred due to mechanical contact and washing. When transfer was restricted, surface concentrations at unexposed skin were similar to levels in breath and were strongly correlated to methanol concentrations in blood. While results are preliminary due to the small sample sizes and several unresolved experimental issues, the simple, rapid, and noninvasive skin headspace measurements appear useful as a biological exposure indicator that clearly shows the presence and site of a dermal exposure, and measurements at unexposed skin reflect concentrations in blood.
Batterman
S A
SA
Environmental and Industrial Health, University of Michigan, Ann Arbor 48109-2029, USA.
Franzblau
A
A
Zhou
N
N
D000328:Adult; D000393:Air Pollutants / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D001944:Breath Tests; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006801:Humans; D000432:Methanol / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D008875:Middle Aged; D012867:Skin / Q000737:chemistry*; D013997:Time Factors
D000393:Air Pollutants; D000432:Methanol