Bacterial growth on antibiotic-loaded acrylic cement. A prospective in vivo retrieval study.
Twenty-three patients with intraoperative culture-proven periprosthetic infection of the hip or knee were enrolled in a prospective cement retrieval study. All were treated with a two-stage technique using antibiotic-loaded acrylic cement as an antibiotic depot. Staphylococcus epidermidis was the most commonly isolated organism (19 of 23 cases). Cement and tissue were examined at second-stage revision for the presence of viable organisms. In this series, no organisms were isolated from the surface of the cement, a 100% concordance with the tissue cultures. A subsequent failure rate of 4.4% (1 case) was seen in this series. Investigation suggests this may represent reinfection from a new strain of organism rather than failure of eradication of the original infection.
Kendall
R W
RW
Department of Orthopaedics, University of British Columbia, Vancouver, Canada.
Duncan
C P
CP
Beauchamp
C P
CP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D019072:Antibiotic Prophylaxis; D001843:Bone Cements; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D012086:Reoperation; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013212:Staphylococcus epidermidis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D008768:Methylmethacrylates; D020366:Methylmethacrylate