Dietary management of pancreatic beta-cell homeostasis and control of diabetes.
Undernutrition, overnutrition and malnutrition, in addition to several other environmental insults have been claimed to play roles in the etiopathogenesis of insulin-dependent and -independent diabetes. These factors are known to alter the beta-cell function and disturb its homeostasis, i.e. qualitative and quantitative changes in its activity. This can lead to disturbed glucose homeostasis and thereby diabetes. It is possible to stop this vicious cycle and reduce the incidence of diabetes by restoring the homeostasis of beta-cell function through proper diabetes management and maintainance of an appropriate dietary milieu. It has been suggested that beta-cell dysfunction or death occurs by oxyradical mediated processes. Adequate stimulation of beta cells through high carbohydrate and fibre intake, and reduced oxidative tone by caloric restriction (low protein and saturated fat), supplementation with antioxidants (vitamin E and D) and polyunsaturated essential fatty acids may prevent loss or even restore the beta-cell activity from environmental diabetogenic insults.
Ramesh
B
B
National Facility For Animal Tissue and Cell Culture, 'Jopasana', Kothrud, Pune, India.
D000818:Animals; D003920:Diabetes Mellitus / Q000178:diet therapy* / Q000503:physiopathology / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000503:physiopathology; D003927:Diet, Diabetic; D004435:Eating; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007515:Islets of Langerhans / Q000503:physiopathology; D051379:Mice; D016688:Mice, Inbred NOD; D008954:Models, Biological; D009747:Nutritional Physiological Phenomena; D017382:Reactive Oxygen Species / Q000378:metabolism; D014815:Vitamins / Q000008:administration & dosage
D017382:Reactive Oxygen Species; D014815:Vitamins; D005947:Glucose