title: Nonword repetition as a behavioural marker for inherited language impairment: evidence from a twin study.
abstract: The Children's Nonword Repetition Test (CNRep) was given 39 children with persistent language impairment (LI), 13 with a history of having received speech-language therapy (resolved LI), and 79 controls, all aged from 7 to 9 years. The children with LI were twins who had participated in a previous genetic study. Children with resolved LI, as well as those with persistent LI, were significantly impaired on the CNRep. Comparisons of MZ and DZ twins indicated significant heritability of a CNRep deficit. It is concluded that CNRep provides a marker of the phenotype of heritable forms of developmental language impairment.
authors: MRC Applied Psychology Unit, Cambridge, UK.
authors: D V
authors: DV
authors: Bishop
authors: T
authors: T
authors: North
authors: C
authors: C
authors: Donlan
mesh_terms: D002648:Child; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D007807:Language Tests; D007808:Language Therapy; D008297:Male; D010641:Phenotype; D010700:Phonetics; D013064:Speech Disorders / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D013070:Speech Therapy; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics
chemical_list: D005819:Genetic Markers