beta-lactam antibiotics in the treatment of neuroborreliosis in children: preliminary results.
In vitro beta-lactam antibiotics like ceftriaxone and penicillin G sodium have been shown to be active against Borrelia burgdorferi. Results of quantitative determinations of both antibiotic substances in the CSF for children are limited. Seventy-five children (median age 96 months, range 10 to 176 months) with probable or definite neuroborreliosis were treated with ceftriaxone (1 x 50-90 mg/kg/day) or penicillin G sodium (4 x 80,000-120,000 IU/kg/day) intravenously. On day 10 of therapy levels of penicillin G sodium (1,1.5,2,3,4, 5, or 6 h after i.v. administration), and ceftriaxone (1,2,4,6,12 or 24 h after i.v. administration) in serum and CSF were measured with a micro agar diffusion bioassay. Results demonstrate that after 5 h penicillin G sodium in CSF was above the minimal inhibitory concentration (MIC) but after 6 h penicillin G sodium levels were below the determination limit in 60% of the cases. All ceftriaxone results in CSF-even after 24 h-were above MIC. Penicillin G sodium serum values ranged from 46.6 to 0.1 mg/L (1 to 6 h post dose) and ceftriaxone serum values from 261 to 5 mg/l (1 to 24 h post dose). The role of penicillin G sodium and ceftriaxone and administration intervals of both antibiotics in the therapy of neuroborreliosis in children are discussed.
Millner
M M
MM
Universitätskinderklinik Graz, Arbeitsgruppe Kinderneuropsychiatrie, Austria.
Thalhammer
G H
GH
Dittrich
P
P
Spork
K D
KD
Brunner
M
M
Georgopoulos
A
A
D000293:Adolescent; D002443:Ceftriaxone / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008193:Lyme Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008297:Male; D009422:Nervous System Diseases / Q000382:microbiology; D010400:Penicillin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D010406:Penicillins / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D013997:Time Factors
D002511:Cephalosporins; D010406:Penicillins; D002443:Ceftriaxone; D010400:Penicillin G