Metabolism of paracetamol in children with chronic liver disease.
OBJECTIVE
To study the metabolism of single doses of paracetamol in paediatric patients with chronic liver disease admitted to a hospital liver disease clinic.


RESULTS
Thirteen paediatric patients, aged 7 months to 12 years, with chronic liver disease of varying severity were studied. In these children, paracetamol elimination half-life was negatively correlated with serum albumin and positively with prothrombin time, as previously reported in adults with liver disease. The rate constant of glucuronide formation was higher in the children with liver disease compared to the value reported in healthy children of similar ages. The rate constant of the formation of paracetamol sulphate was no different from that in normal children. The 36 h urinary paracetamol glucuronide to sulphate ratio was 1.4 (95% CI 0.8 to 1.7). This mean ratio was higher than in healthy children (0.81 and 0.75) but not significantly so, probably because of a Type 1 error due to the inevitable small sample size arising from the nature of the population being studied.


CONCLUSIONS
The present study provides reassuring additional data to indicate that, at least for single doses, there is no cause for concern in the use of paracetamol in children with chronic liver disease.
al-Obaidy
S S
SS
School of Pharmacy, Queen's University of Belfast, Northern Ireland.
McKiernan
P J
PJ
Li Wan Po
A
A
Glasgow
J F
JF
Collier
P S
PS
D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001711:Biotransformation; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D005965:Glucuronates / Q000652:urine; D006207:Half-Life; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000378:metabolism*; D009752:Nutritional Status; D010084:Oxidation-Reduction
D018712:Analgesics, Non-Narcotic; D005965:Glucuronates; D000082:Acetaminophen