A systematic analysis of average molecular weights and gelation conditions for branched immune complexes: the interaction between a multivalent antigen with distinct epitopes and many different types of bivalent antibodies.
A systematic model, based on standard equilibrium expressions and probability theory, is presented to calculate average molecular weights and gelation conditions for the immune system consisting of a single type of antigens with three (or more) different epitopes and three (or more) types of bivalent antibodies. Molecular weights Mn, Mw, Mz, and any other higher average molecular weights of formed branched antigen-antibody complexes in such an immune system are calculated directly without determining the whole distribution. The conditions for the formation of gel complexes also can be determined by this model.
Shiau
L D
LD
Department of Chemical Engineering, Chang Gung College of Medicine and Technology Kweishan, Taoyuan Taiwan, R.O.C.
D018033:Antibodies, Bispecific / Q000737:chemistry; D000936:Antigen-Antibody Complex / Q000737:chemistry*; D000939:Epitopes / Q000737:chemistry; D005782:Gels; D008956:Models, Chemical; D008970:Molecular Weight
D018033:Antibodies, Bispecific; D000936:Antigen-Antibody Complex; D000939:Epitopes; D005782:Gels