title: Antenatal invasive and noninvasive management of alloimmune thrombocytopenia.
abstract: The outcome analysis of 10 pregnancies at risk for neonatal alloimmune thrombocytopenia (NAIT) is presented. An experimental protocol of cordocentesis and maternal administration of intravenous immunoglobulin (IVIG) is compared to a control group of older untreated affected siblings. The outcome in pregnancies treated with IVIG shows improved fetal platelet count in 70% and no intraventricular hemorrhage. We conclude that maternal administration of IVIG appears to improve clinical outcome in fetuses at risk for NAIT.
authors: Division of Maternal-Fetal Medicine, British Columbia Women's Hospital, University of British Columbia, Vancouver, Canada.
authors: I
authors: I
authors: Kornfeld
authors: R D
authors: RD
authors: Wilson
authors: P
authors: P
authors: Ballem
authors: B K
authors: BK
authors: Wittmann
authors: D F
authors: DF
authors: Farquharson
mesh_terms: D002543:Cerebral Hemorrhage / Q000209:etiology; D017218:Cordocentesis; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007518:Isoantibodies; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies