Effect of captopril and thiorphan on the proliferation of human neoplastic cell lines and their influence on cytostatic activity of interferon alpha or cytotoxic activity of doxorubicin.
We have assessed the effect of thiorphan or captopril on proliferation of two human tumor cell lines, A549 and HL60 including their influence on the cytostatic activity of interferon alpha or doxorubicin. The results showed that captopril inhibits the proliferation of both A549 and HL60 cells lines but thiorphan has antiproliferative effect only on A549 cells in a dose-dependent manner. However, neither captopril nor thiorphan administered in combination with interferon alpha or doxorubicin enhanced cytotoxic potential of doxorubicin and cytostatic activity of interferon alpha.
Kowalski
J
J
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice, Poland.
Belowski
D
D
Wielgus
J
J
Gabryel
B
B
Klin
M
M
Herman
Z S
ZS
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D007700:Kinetics; D011994:Recombinant Proteins; D015244:Thiorphan / Q000008:administration & dosage / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D004317:Doxorubicin; D002216:Captopril; D015244:Thiorphan