Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases.
To investigate whether nitric oxide (NO) plays a role in degenerative neurologic disease (DND), we measured nitrite, nitrate and cyclic GMP in cerebrospinal fluid (CSF) samples from patients with Parkinson's disease (PD), spinocerebellar ataxia (SCA) and amyotrophic lateral sclerosis (ALS). We found no significant change in CSF nitrite, nitrate or cyclic GMP in patients with any DND compared with control values. These results suggest that NO production is preserved in PD, SCA and ALS.
Ikeda
M
M
Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
Sato
I
I
Yuasa
T
T
Miyatake
T
T
Murota
S
S
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid / Q000378:metabolism; D015415:Biomarkers; D006152:Cyclic GMP / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D009566:Nitrates / Q000134:cerebrospinal fluid*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000378:metabolism; D013132:Spinocerebellar Degenerations / Q000134:cerebrospinal fluid / Q000378:metabolism
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D006152:Cyclic GMP