[Precapillary pulmonary arterial hypertension disclosing systemic lupus erythematosus].
Precapillary pulmonary hypertension was diagnosed in a 29 year old woman who became progressively more breathless (NYHA Class III) after her pregnancy, two years previously: systolic pulmonary artery pressure was 120 mmHg with an arterio-capillary pressure gradient of 30 mmHg. She had anti-nuclear autoantibodies detectable at 1/1000 and anti-DNA autoantibodies at 1/800 without any other manifestation of lupus. Treatment with prednisone (2 mg/kg/day) resulted in regression of her dyspnoea with a decrease of systolic pulmonary artery pressure to 65 mmHg, and of the arterio-capillary gradient to 15 mmHg; the lupus serology became negative with a clinical follow-up of 37 months. This observation shows that systemic lupus erythematosus may present with precapillary pulmonary hypertension, the conventional treatment of which may be successfully completed by steroid therapy.
Fauchier
L
L
Service de cardiologie B, hôpital Trousseau, Tours.
Goupille
P
P
Babuty
D
D
Marchal
C
C
Valat
J P
JP
Fauchier
J P
JP
Cosnay
P
P
D000328:Adult; D004417:Dyspnea / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011669:Pulmonary Wedge Pressure; D016896:Treatment Outcome
D005938:Glucocorticoids; D011241:Prednisone
Hypertension artérielle pulmonaire précapillaire révélant un lupus érythémateux systémique.