Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32.
Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at theta = 0 and alpha of 0.5 and nearby markers also produced positive values.
Lin
M W
MW
Department of Neuroscience and Psychological Medicine, Institute of Psychiatry, London, UK.
Curtis
D
D
Williams
N
N
Arranz
M
M
Nanko
S
S
Collier
D
D
McGuffin
P
P
Murray
R
R
Owen
M
M
Gill
M
M
D000300:Adoption; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D004200:Diseases in Twins; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D012727:Sex Characteristics
D005819:Genetic Markers