[Taurine induces an imbalance in the pool of neuroactive amino acids and biogenic amines in regions of the brain].
The paper deals with the consequences of exogenous taurine (Tau) administration (650 mg/kg, i.p., singly, for 30 min) and possible mechanisms of this compound participation in the formation of the structure of the neuroactive amino acid pool, biogenic amines and their metabolites in the hypothalamus (H), basal ganglia (BG) and cerebellum (C) of the brain of male rats weighing 160-280 g. The concentrations of amino acids as OPA derivatives were determined by reverse-phase HPLC and the content of biogenic amines and their metabolites--by ion-pair HPLC-ECD. The Tau load was followed by an elevation of the concentrations of glutamate, aspartate and their amides, GABA and tyrosine concentrations in cerebellum whereas in basal ganglia that of tyrosine and dopamine. The tryptophan, beta-alanine, dioxyphenylacetic acid, dopamine and norepinephrine levels were diminished in hypothalamus. The metabolic and functional relationships governing the imbalance of the neuroactive amino acid and biogenic amine pool in the neuroactive amino acid and biogenic amine pool in the CNS occurring after the Tau administration in vivo are interpreted using statistical analysis.
Nefedov
L I
LI
Doroshenko
E M
EM
Smirnov
V Iu
VIu
Zav'ialova
G N
GN
Klimovich
I I
II
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D013654:Taurine / Q000494:pharmacology*
D000596:Amino Acids; D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D013654:Taurine
Taurin indutsiruet disbalans pula neĭroaktivnykh aminokislot i biogennykh aminov v otdelakh golovnogo mozga.