Influence of gold salts treatment on the serum concentration of IL-1 and IL-2 in patients with rheumatoid arthritis.
Eighteen subjects (2 males, 16 females) with rheumatoid arthritis were treated with gold salts for 6 months. The statistically significant decrease of IL-1 and IL-2 levels during the treatment was observed. The mean serum concentrations of IL-1 and IL-2 decreased from 41.0 +/- 11.5 to 28.6 +/- 7.3 (p < 0.001) and 98.3 +/- 57.6 to 29.3 +/- 20.5 fmol/ml (p < 0.001), respectively. This decrease was accompanied by a decline of serum concentration of acute phase proteins and immunoglobulins. These results can explain a strong anti-inflammatory action of gold salts in patients with rheumatoid arthritis.
Lewandowicz
J
J
Division of Rheumatology, Medical Academy, Lódź, Poland.
Dabkowska
B
B
Nowak
D
D
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D018501:Antirheumatic Agents; D006242:Haptoglobins; D007136:Immunoglobulins; D007375:Interleukin-1; D007376:Interleukin-2; D006052:Gold Sodium Thiomalate