Natriuretic peptides and hypertension.
Natriuretic peptides are produced in the brain, heart and vasculature, and cause vasodilation, sodium excretion, and diuresis. Recent advances indicate that they play important roles in blood-pressure homeostasis, both in normal and in pathophysiological conditions. Although therapeutic interventions which elevate plasma natriuretic peptide levels do not have great antihypertensive efficacy, animal studies suggest that they may be useful in combination treatment strategies.
Prins
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Division of Endocrinology, Veteran Affairs Medical Center, Long Beach, California 90822, USA.
Biesiada
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Levin
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D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D018000:Receptors, Peptide / Q000378:metabolism
D009419:Nerve Tissue Proteins; D011506:Proteins; D018000:Receptors, Peptide; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; D009320:Atrial Natriuretic Factor