Wound healing effect of malotilate in rats.
The wound healing effect of malotilate (CAS 59937-28-9, NKK-105) was investigated by using an excisional skin-wound model produced on the back of normal and healing-impaired (induced by prednisolone pretreatment) rats. The rapid decrease in the square measure of wound areas and the improvement in the histological evaluation clarified that 0.3% and 1% cream preparations of malotilate were obviously effective in accelerating spontaneous healing in the normal rats. The accelerative effect of malotilate cream preparations was likely superior to that of an ointment containing 5% deproteinized calf blood extract used as a reference agent. The same effect was also observed in the healing-impaired rats. The histological findings revealed that a thicker and more cellular granulation tissue, which in turn created an adequate bed for rapid re-epithelization, was formed in the malotilate-treated animals. Acceleration of granulation tissue formation by malotilate was also supported by the cotton pellet implantation method. It is concluded from these results that malotilate seems to be a promising agent for topical wound therapy.
Niwano
Y
Y
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd., Osaka, Japan.
Koga
H
H
Sakai
A
A
Kanai
K
K
Hamaguchi
H
H
Uchida
M
M
Tachikawa
T
T
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003368:Gossypium; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D008297:Male; D008314:Malonates / Q000008:administration & dosage / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D012867:Skin / Q000293:injuries / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000473:pathology
D000893:Anti-Inflammatory Agents; D008314:Malonates; D011239:Prednisolone; C024808:diisopropyl 1,3-dithiol-2-ylidenemalonate