Targeting T cells for GVHD therapy.
Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss the development of immunotoxin approaches for either GVHD prevention or treatment, and explore their limitations.
Vallera
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Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota, Minneapolis 55455, USA.
D000818:Animals; D017252:CD3 Complex / Q000276:immunology; D004195:Disease Models, Animal; D005544:Forecasting; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D008212:Lymphocyte Depletion; D051379:Mice; D013601:T-Lymphocytes / Q000187:drug effects*
D017252:CD3 Complex; D000922:Immunotoxins