title: Psoriasin: a novel chemotactic protein.
abstract: Inflammatory skin disorders such as psoriasis show a preferential epidermal infiltration of neutrophils and T lymphocytes. This observation raises a question as to which factors determine the appearance and composition of leukocyte tissue infiltrations. Previously, we described a low molecular mass calcium-binding protein (psoriasin, molecular mass 11,457 Da, pI 6.77) belonging to the S1OO family that is highly upregulated in psoriatic keratinocytes and whose expression patterns implied a role in the inflammatory response. Here we report that human psoriasin is a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes and neutrophils at concentrations of about 10(-11) M. Psoriasin is not structurally related to the alpha or the beta chemokine subfamilies or to lymphotactin, a member of a newly described class of chemokines. Thus, we have observed a chemotactic protein outside the chemokine subfamilies that could be an important new inflammatory mediator.
authors: Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
authors: T
authors: T
authors: Jinquan
authors: H
authors: H
authors: Vorum
authors: C G
authors: CG
authors: Larsen
authors: P
authors: P
authors: Madsen
authors: H H
authors: HH
authors: Rasmussen
authors: B
authors: B
authors: Gesser
authors: M
authors: M
authors: Etzerodt
authors: B
authors: B
authors: Honoré
authors: J E
authors: JE
authors: Celis
authors: K
authors: K
authors: Thestrup-Pedersen
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002630:Chemotactic Factors / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000502:physiology; D011994:Recombinant Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; D002630:Chemotactic Factors; D011994:Recombinant Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human; D003094:Collagen