Glibenclamide antagonizes the inhibitory effect of morphine on gall bladder emptying.
Egg yolk-induced gall-bladder emptying in mice was used to investigate the effect of glibenclamide and minoxidil (ATP-dependent K(+)-channel modulators) on biliary tract effects of morphine. The inhibitory effect of morphine (1-4 mg kg-1, i.p.) on egg yolk-induced gall-bladder emptying was completely blocked by pretreatment with naloxone (2 mg kg-1, i.p.) or glibenclamide (0.65 mg kg-1, i.p.) whereas, pretreatment with minoxidil (0.65 mg kg-1, i.p.) did not modify the inhibitory effect of morphine on gall-bladder emptying. Our results suggest that biliary-tract actions of morphine are mediated through glibenclamide-sensitive K+ channels similar to those involved in the analgesic action of morphine.
Patil
B M
BM
Department of Pharmacology, College of Pharmacy, Campus, Belgaum, India.
Thakker
P R
PR
D000818:Animals; D004347:Drug Interactions; D016473:Gallbladder Emptying / Q000187:drug effects*; D005905:Glyburide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008914:Minoxidil / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*
D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D008914:Minoxidil; D009020:Morphine; D005905:Glyburide