Risk estimation--an overview: disease risk estimation based upon animal bioassays.
Much more could be written about the issues addressed here, as well as about issues that are not even mentioned. The goal was to present a brief overview of some of the techniques and issues in quantitative health risk assessment based upon animal data. Hopefully, this overview will provoke some attention to specific in risk assessment that require more research. Perhaps the bibliographic references given will lead to other papers.
Gaylor
D W
DW
National Center for Toxicological Research U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
D000818:Animals; D001681:Biological Assay / Q000592:standards; D002273:Carcinogens / Q000009:adverse effects*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D017408:Guidelines as Topic; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D012015:Reference Standards; D018570:Risk Assessment; D014481:United States; D014486:United States Food and Drug Administration
D002273:Carcinogens