Adenocarcinoma of the esophagus complicating Cornelia de Lange syndrome.
Complicated gastroesophageal reflux disease may be seen in a variety of congenital developmental syndromes, but progression of Barrett's metaplasia to adenocarcinoma is rare. We report the first case of esophageal adenocarcinoma in a young adult with Cornelia de Lange syndrome who had long-standing gastroesophageal reflux disease. We review the literature concerning Barrett's metaplasia in children and make recommendations for surveillance.
DuVall
G A
GA
Division of Gastroenterology, University of Texas Medical Branch, Galveston, USA.
Walden
D T
DT
D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D000328:Adult; D001471:Barrett Esophagus / Q000209:etiology; D003635:De Lange Syndrome / Q000150:complications*; D004938:Esophageal Neoplasms / Q000209:etiology* / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D008297:Male