[Bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and the influence of loratadine and beclomethasone on this hyperresponsiveness].
60 patients aged 16 to 46 years with seasonal allergic rhinitis were selected for study. Daily symptom scores of seasonal allergic rhinitis and nonspecific bronchial hyperresponsiveness to histamine (PC20H in mg/ml) before, during the pollen season and after 3 weeks of treatment with loratadine, beclomethasone dipropionate were evaluated. The control group received oxymetazoline. Nonspecific bronchial hyperresponsiveness for 11 patients (18.3%) before the seasons was observed. At the beginning of the season frequency of nonspecific bronchial hyperresponsiveness increased to 26.3% and to 36.8% after 3-week treatment course. Bronchial hyperresponsiveness was not related to any of the way of treatment. The patients treated with beclomethasone dipropionate and oxymetazoline showed significant relief of nasal symptoms. The patients without bronchial hyperresponsiveness showed lower value of symptom scores.
Kroczyńska-Bednarek
J
J
Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.
Gondorowicz
K
K
Kalinowska-Graczyk
M
M
Grzelewska-Rzymowska
I
I
Rozniecki
J
J
D000293:Adolescent; D000328:Adult; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D001507:Beclomethasone / Q000627:therapeutic use*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014663:Nasal Decongestants / Q000627:therapeutic use; D010109:Oxymetazoline / Q000627:therapeutic use; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000188:drug therapy*
D018926:Anti-Allergic Agents; D014663:Nasal Decongestants; D017336:Loratadine; D010109:Oxymetazoline; D001507:Beclomethasone
Wystepowanie nieswoistej nadreaktywności oskrzeli u chorych na sezonowy alergiczny neizyt nosa oraz wpływ loratadyny i beklometazonu na te nadreaktywność.