Transplacental transport of netobimin metabolites in ewes.
Neither netobimin (NTB) nor its metabolite albendazole (ABZ) were found in plasma after an oral administration of 20 mg/kg of NTB to pregnant ewes during the last third of gestation. ABZ metabolites, albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO2) were found in plasma 30 min and 2 h, respectively, after administration. The maximal plasma concentration (Cmax) of ABZSO was detected at 11.6 +/- 1.0 h and for ABZSO2 at 16.5 +/- 2.3 h. The plasma levels of the latter remained constant for 36 h, and decreased as ABZSO was removed from the blood. Jugular plasma levels of both metabolites did not differ significantly from those observed in the ovarian vein, suggesting that there were no exchanges between foetal and placental tissues. Both metabolite concentrations were similar in the umbilical vein and artery and in the amniotic and allantoic fluids, their values were half the maternal plasma concentration, leading to the conclusion that there was transplacental movement of metabolites. Both metabolites reached the foetus and could be responsible for the teratogenicity of NTB in sheep.
Cristofol
C
C
Unitat de Farmacologia, UAB, Bellaterra, Spain.
Carretero
A
A
Fernandez
M
M
Navarro
M
M
Sautet
J
J
Ruberte
J
J
Arboix
M
M
D015766:Albendazole / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D000871:Anthelmintics / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006146:Guanidines / Q000097:blood / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012756:Sheep
D000871:Anthelmintics; D006146:Guanidines; C027187:albendazole sulfone; D015766:Albendazole; C027186:albendazole sulfoxide; C049626:netobimin