title: Prostate volumes defined by magnetic resonance imaging and computerized tomographic scans for three-dimensional conformal radiotherapy.
abstract: OBJECTIVE
  To compare the prostate volumes defined on magnetic resonance imaging (MRI), and noncontrast computerized tomographic (CT) scans used for three-dimensional (3D) treatment planning.
  
  
  METHODS
  Ten patients were simulated for treatment using immobilization and a retrograde urethrogram. 3D images were used to compare prostate volumes defined by MRI (4-6 mm thick slices) and CT images (5 mm thick slices). Prostate volumes were calculated in cm(3) using the Scanditronix 3D planning system. MRI/CT images were merged using bony anatomy to define the regions of discrepancy in prostate volumes.
  
  
  RESULTS
  The mean prostate volume was 32% larger (range-5-63%) when defined by noncontrast CT compared to MRI. The areas of nonagreement tended to occur in four distinct regions of discrepancy: (a) the posterior portion of the prostate, (b) the posterior-inferior-apical portion of the prostate, (c) the apex due to disagreement between a urethrogram based definition and the location defined by MRI, (d) regions corresponding to the neurovascular bundle.
  
  
  CONCLUSIONS
  There is a tendency to overestimate the prostate volume by noncontrast CT compared to MRI. Awareness of this tendency should allow us to be to more accurately define the prostate during 3-D treatment planning.
authors: Department of Radiation Oncology, University of California San Francisco/ Mt. Zion Cancer Center 94143-0226, USA.
authors: M
authors: M
authors: Roach
authors: P
authors: P
authors: Faillace-Akazawa
authors: C
authors: C
authors: Malfatti
authors: J
authors: J
authors: Holland
authors: H
authors: H
authors: Hricak
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed