Human insulin-induced lipoatrophy. Successful treatment using a jet-injection device.
OBJECTIVE
To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.


METHODS
We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.


RESULTS
The loss of subcutaneous tissue in the injection areas was demonstrated and measured by high-frequency ultrasound. Dermatologic exam demonstrated a severe reduction of fat tissue. After 8 months of administration of human insulin by a jet injector, there were no more new lesions of lipoatrophy and those affected areas were substantially ameliorated.


CONCLUSIONS
Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.
Logwin
S
S
Endocrinology Unit, Hospital Clinic, Barcelona, Spain.
Conget
I
I
Jansa
M
M
Vidal
M
M
Nicolau
C
C
Gomis
R
R
D000328:Adult; D003923:Diabetes Mellitus, Lipoatrophic / Q000139:chemically induced*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D004867:Equipment Design; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects*; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D013594:Syringes
D006442:Glycated Hemoglobin; D007328:Insulin; D011994:Recombinant Proteins