title: The influence of Microgynon and Diane-35, two sub-fifty ovulation inhibitors, on voice function in women.
abstract: The early days of oral contraceptives showed some evidence that these medications may have caused undesirable side effects on the voice, mainly in terms of virilization. In a random study carried out at the university hospitals of Jena and Berlin (Charité), two more recent drugs were tested in this regard, one containing cyproterone acetate (Diane-35) and the other one levonorgestrel (Microgynon), both from Schering. Ninety-one patients took part in extensive clinical and instrumental phoniatric investigations of voice function over a period of one year. No significant side effects on the voice could be proven for the two preparations. Gynecological and clinical effects of both Diane-35 and Microgynon were similar during the one-year study period. Women taking Diane-35 had less intracyclic bleedings and amenorrhea. Also, acne was more favorably influenced by Diane-35.
authors: Dept. of Phoniatry and Pediatric Audiology, ENT Clinic Charite, University Hospital of Berlin, Germany.
authors: J
authors: J
authors: Wendler
authors: C
authors: C
authors: Siegert
authors: P
authors: P
authors: Schelhorn
authors: G
authors: G
authors: Klinger
authors: S
authors: S
authors: Gurr
authors: J
authors: J
authors: Kaufmann
authors: S
authors: S
authors: Aydinlik
authors: T
authors: T
authors: Braunschweig
mesh_terms: D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D017373:Cyproterone Acetate / Q000494:pharmacology*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects*; D010699:Phonation / Q000187:drug effects*; D016037:Single-Blind Method
chemical_list: D000726:Androgen Antagonists; D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C032640:Cyproterone acetate, ethinyl estradiol drug combination; D019304:Ethinyl Estradiol-Norgestrel Combination