title: [Changes in the immunologic status related to the duration of the anesthesia/surgery procedure].
abstract: OBJECTIVE
  To study the effect of the trauma of anesthesia and surgery, and their duration, on immune status.
  
  
  METHODS
  Fifty patients undergoing cholecystectomy were studied in 2 groups. In group A surgery was of short duration ( < 60 min) and in group B surgery was longer ( > 60 min). Immunological analysis were performed at 5 times: t0 (before surgery), t1 (1 h), t2 (24 h), t3 (4 days) and t4 (7 days).
  
  
  RESULTS
  Group A patients experienced a non significant decrease in T lymphocytes, activated T lymphocytes and B lymphocytes, with levels returning to normal after 7 days. T-suppression, on the other hand, decreased significantly in the first 24 h, but gradually returned to normal after 7 days. T lymphocytes, activated T lymphocytes and B lymphocytes decreased in group B and regressed after 7 days. The population of B lymphocytes decreased significantly and had not fully recovered 7 days after surgery.
  
  
  CONCLUSIONS
  The act of anesthesia/surgery depresses immune response in function of duration, with the effect being greater when surgery lasts longer.
authors: Servicio de Anestesiología y Reanimación, Hospital Universitario de Salamanca.
authors: C
authors: C
authors: Muriel
authors: A
authors: A
authors: García-Sánchez
authors: F
authors: F
authors: Sánchez
authors: A
authors: A
authors: Zaballos
authors: J C
authors: JC
authors: Garzón
authors: E
authors: E
authors: Sánchez-Barrado
mesh_terms: D000328:Adult; D000758:Anesthesia; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative
vernacular_title: Alteraciones del estado inmunológico en función de la duración del acto anestésico-quirúrgico.