TrkA, TrkB and p75 mRNA expression is developmentally regulated in the rat retina.
We examined the cellular distribution of mRNAs coding for the neurotrophin receptors TrkA, TrkB and p75 in the rat retina during early postnatal development. At P0 (postnatal day 0), mRNAs coding for each of the three receptors were detected in the ganglion cell layer (GCL) and in the inner plexiform layer (IPL), the latter structure essentially containing retinal ganglion cell processes at this developmental stage. At P5, the innermost part of the inner nuclear layer (INL) also expressed TrkA, TrkB and p75 mRNAs. Finally, the GCL, IPL and the whole INL of P10 retinae were labeled by the three probes. The developmentally regulated expression of these receptors underlies a possible role for neurotrophins in the differentiation and survival of retinal cells.
Ugolini
G
G
Scuola Normale Superiore, Pisa, Italy.
Cremisi
F
F
Maffei
L
L
D000818:Animals; D000831:Animals, Newborn; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D017403:In Situ Hybridization; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D020801:Receptor, Ciliary Neurotrophic Factor; D020800:Receptor, Nerve Growth Factor; D020917:Receptor, trkA; D017475:Receptors, Nerve Growth Factor / Q000235:genetics*; D012160:Retina / Q000254:growth & development / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D020801:Receptor, Ciliary Neurotrophic Factor; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA