Effect of bupivacaine-induced spinal block on the hypnotic requirement of propofol.
The hypnotic dose-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic or lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.
Tverskoy
M
M
Department of Anesthesia and Intensive Care, Rebecca Sieff' Government Hospital, Safed, Israel.
Fleyshman
G
G
Bachrak
L
L
Ben-Shlomo
I
I
D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D002045:Bupivacaine; D015742:Propofol