title: Multimodal evoked potentials in HIV-1-seropositive patients: relationship between the immune impairment and the neurophysiological function.
abstract: Multimodal evoked potentials (PRVEP, BAEP, mSEP) were recorded in 56 HIV-1 seropositive outpatients free from opportunistic CNS pathologies and/or overt HIV-1 encephalopathy. EPs were altered in 17 of 39 (43.6%) seropositive subjects without AIDS (group A) and in 13 of 17 (76.5%) patients with AIDS (group B). A high incidence of subclinical alterations (30.8%) were found in group A patients. Significant BAEP (I-III, III-V, I-V) interpeak latency and mSEP (N9-N13, N9-N20) conduction time prolongations were found in group A and B patients. PRVEP P100 was significantly prolonged only in group B. An inverse relationship between BAEP interpeak latencies and CD4 count was found. Our findings support the hypothesis of an important role of immunodepression in the development of neurophysiologic abnormalities, together with a preferential involvement of acoustic pathways, in the course of HIV-1 infection.
authors: Istituto di Clinica delle Malattie Nervose e Mentali, Università La Sapienza, Roma, Italia.
authors: F
authors: F
authors: Pierelli
authors: C
authors: C
authors: Garrubba
authors: G
authors: G
authors: Tilia
authors: L
authors: L
authors: Parisi
authors: F
authors: F
authors: Fattapposta
authors: G
authors: G
authors: Pozzessere
authors: G
authors: G
authors: Soldati
authors: P
authors: P
authors: Stanzione
authors: G
authors: G
authors: D'Offizi
authors: I
authors: I
authors: Mezzaroma
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D018791:CD4 Lymphocyte Count; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values