Electrolyte content of serum, erythrocyte, kidney and heart tissue in salt induced hypertensive rats.
The effect of salt load on the systolic blood pressure (SBP) and electrolyte levels of serum, erythrocyte, kidney and heart tissue was studied in rats. NaCl treatment increased sodium (5.69 +/- 0.4 mmol/L p < 0.001, 149.8 +/- 4.0 mEq/L, p < 0.001) and decreased potassium (112.6 +/- 2.4 mmol/L p < 0.001, 5.0 +/- 0.2 mEq/L, p < 0.001) in red cell and serum respectively. A decreased level of serum magnesium (1.4 +/- 0.3 mEq/L, p < 0.005) was observed. Sodium content was increased in both heart (39.93 +/- 2.9 mumol/g, p = n.s) and kidney tissues (44.39 +/- 0.5 mumol/g, p < 0.001). A pronounced increase in intracellular calcium (2.54 +/- 0.2 mumol/g, p < 0.001) and a decrease of magnesium content (6.05 +/- 0.8 mumol/g, p < 0.001) was observed in kidney tissue after treatment. The results suggested that marked changes in electrolyte levels of erythrocytes, serum, heart and kidney tissues in NaCl loaded rats may play a definite role in the development of salt induced hypertension.
Mahboob
T
T
Department of Biochemistry, University of Karachi, Pakistan.
Mumtaz
M
M
Haleem
M A
MA
D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism; D004573:Electrolytes / Q000097:blood / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride
D004573:Electrolytes; D012965:Sodium Chloride; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium