Inhibitory effect of propofol on sympathetic neurotransmission results in changes of plasma neuropeptide Y in rats.
1. The effects of propofol on sympathetic neurotransmission and changes of plasma level of neuropeptide Y-like immunoreactivity (NPY-ir) were investigated in rats. 2. Intraperitoneal injection of propofol into rats lowered the systemic blood pressure and plasma NPY-ir in a dose-dependent manner. 3. Decrease of plasma NPY-ir induced by propofol was not modified in adrenalectomized rats. In the activation of adrenergic neurotransmission by a ganglionic nicotinic agonist, elevation of plasma NPY-ir was also reduced by propofol indicating the direct effect on peripheral adrenergic nerve terminals. 4. Plasma level of NPY-ir reversed in parallel with the recovery of anaesthesia induced by propofol. After an intracerebroventricular injection of propofol into the rats, both the lowering of plasma NPY-ir and the induction of anaesthesia were observed. Thus, a central nervous system effect of propofol can also be considered in its effect on plasma NPY-ir. 5. The data suggest that propofol has the ability to lower plasma NPY-ir in rats through an inhibition of adrenergic neurotransmission via central nervous pathway and/or peripheral nerve terminal blockade.
Chang
C L
CL
Department of Anesthesiology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, Republic of China.
Tsai
Y C
YC
Niu
C S
CS
Hung
S F
SF
Cheng
J T
JT
D000315:Adrenalectomy; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004246:Dimethylphenylpiperazinium Iodide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005731:Ganglionic Stimulants / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018686:Anesthetics, Intravenous; D005731:Ganglionic Stimulants; D009478:Neuropeptide Y; D004246:Dimethylphenylpiperazinium Iodide; D015742:Propofol