title: Protein phosphatases.
abstract: Protein phosphatases are signal transducing enzymes that dephosphorylate cellular phosphoproteins. The recently determined crystal structures of protein tyrosine and serine/threonine phosphatases reveal that these proteins adopt distinct structures and catalyze dephosphorylation reactions by means of different enzymatic mechanisms. Insights into the basis for substrate specificity and enzyme regulation can also be gained from these crystal structures.
authors: University of Oxford, UK.
authors: D
authors: D
authors: Barford
mesh_terms: D006801:Humans; D008958:Models, Molecular; D010749:Phosphoprotein Phosphatases / Q000737:chemistry* / Q000378:metabolism; D010766:Phosphorylation; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry* / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D013379:Substrate Specificity; D013912:Threonine / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D018909:src Homology Domains
chemical_list: D013912:Threonine; D014443:Tyrosine; D012694:Serine; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases