[Drug-to-drug interactions and pharmaceutical advice].
OBJECTIVE
To describe suspects of drug interactions in primary health care.


METHODS
Descriptive and transversal study during 1 month.


METHODS
Urban health center, primary care, Madrid (Spain).


METHODS
Patients were treated simultaneously with more than 1 drug (145), 2 general practitioners (GP) and 1 pharmacist.


METHODS
GP registered in a sheet-form data from diagnostic and pharmacological treatments. The pharmacist checked the sheet-forms to detect drug interactions, and later assessed to the GP about it. The proposals were classified in 3 ways: no change in treatment; to modify or stop the current treatment, and to monitor plasmatic level or clinical parameters.


RESULTS
333 drug interactions were detected in 145 patients. The 67.5% of interactions produced by 7 groups of drugs: theophylines, diuretics, antacids, benzodiacepines, betablockers, NSAID's and ACE's. GP accepted 74% of pharmacist's proposals (recommendations).


CONCLUSIONS
Seven types of drugs were involved in the main interactions in primary care. The drug interactions increased as more drugs takes a patient in an accelerated trend. Older than 55 were the most affected. GP accepted 3/4 of the recommended pharmacist proposals.
Sáenz Calvo
A
A
Centro de Salud Gómez Acebo, Insalud, Area/Sector XI de Madrid.
Ausejo Segura
M
M
Cruz Martos
E
E
González Alvaro
A
A
Pérez Cayuela
P
P
Rosado López
A
A
D000368:Aged; D003430:Cross-Sectional Studies; D004347:Drug Interactions; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010593:Pharmaceutical Services / Q000706:statistics & numerical data; D011320:Primary Health Care / Q000706:statistics & numerical data; D013030:Spain; D014505:Urban Population
Interacciones medicamento-medicamento y asesoramiento farmacéutico.