The acute phase response to cardiopulmonary bypass in children.
The endocrine phase of the stress response to cardiopulmonary bypass in children is known to be subtly different from that seen in adults. The aim of this investigation was to determine whether there are similar differences in the acute phase response. Thirteen children were studied (mean age 2.65 years). Each child had congenital heart disease and underwent corrective cardiac surgery. Blood samples taken two days prior to operation and at 6, 9, 12, 24, 48 and 120 hours after were analysed for C-reactive protein, albumin, caeruloplasmin, zinc and copper concentrations. Metal:carrier protein molar ratios were also calculated. Results demonstrate changes which, although similar to those seen in adults, differed both quantitatively and qualitatively. This is explained by the concept of immaturity leading to a generally poor capacity for protein synthesis and a relative inability to respond to altered circumstances.
Mitchell
I M
IM
Department of Cardiac Surgery, Royal Hospital for Sick Children, Glasgow.
Brady
L
L
Black
J
J
Jamieson
M P
MP
Pollock
J C
JC
Logan
R W
RW
D000210:Acute-Phase Reaction / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008670:Metals / Q000097:blood*; D011485:Protein Binding
D001798:Blood Proteins; D008670:Metals