[A case of familial amyotrophic lateral sclerosis with markedly decreased accumulation on 123I-MIBG myocardiac scintigraphy and atonic bladder].
A 63-year-old Japanese woman with familial amyotrophic lateral sclerosis (ALS) showed cardiac hypofunction and neurogenic bladder. Her autonomic function was evaluated by means of 123I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy and urodynamic study. (1) MIBG scintigraphy: Both early and late imagings showed severe defects of myocardial 123I-MIBG accumulation despite the normal accumulation of 201thallium. (2) Urodynamic study: Atonic bladder was observed on cystometry. These data indicate that both sympathetic and parasympathetic nerve functions were disturbed, suggesting the possibility that autonomic disturbance in familial ALS may differ from those in sporadic ALS, in which increased sympathetic nervous function has been reported.
Yamamoto
T
T
Department of Neurology, Saitama Medical School.
Tamura
N
N
Nomura
K
K
Kaneko
A
A
Hamaguchi
K
K
D019797:3-Iodobenzylguanidine; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008875:Middle Aged; D011877:Radionuclide Imaging; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000209:etiology*; D014563:Urodynamics
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine