[A study on cryotherapy of experimental posterior penetrating eye injury].
OBJECTIVE
The study was designed to investigate the effects of cryotherapy on intraocular tissues in ocular penetrating injury, and an experimental study was made on rabbits.


METHODS
The penetrating injury models in both eyes of 23 (46 eyes) pigmental rabbits were performed. Cryotherapy was applied after the operation in the left eye but not in the right eye (the control) of each animal. All the pupils of the eyes were dilated and examined by ophthalmoscope and B-scan at different time after the operation. Enucleations were performed at 2 weeks, 6 weeks and 3 months and the enucleated eyeballs were examined pathologically by light and electron microscopy. The synchronous fundus and pathological changes were evaluated and analyzed statistically (Pearson Chi-square test).


RESULTS
The intraocular reaction and proliferation in cryotreated group was much more severe than those in the control one (P = 0.027), especially in the vitreous (P = 0.016). The incidence of tractional retinal detachment in cryotreated group was higher than that in the control.


CONCLUSIONS
It is suggested that the prophylactic cryotherapy in the posterior penetrating ocular injury of rabbits increase intraocular proliferation.
Xiang
L
L
Ophthalmology Department, Beijing Friendship Hospital, Capital Medical University.
Zhang
W
W
Hu
Y
Y
D000818:Animals; D003452:Cryosurgery / Q000009:adverse effects*; D015807:Eye Injuries, Penetrating / Q000601:surgery*; D005260:Female; D008297:Male; D011817:Rabbits; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000209:etiology* / Q000473:pathology; D014822:Vitreous Body / Q000473:pathology