title: Increased aggressive responding in male volunteers following the administration of gradually increasing doses of testosterone cypionate.
abstract: The present study assessed the effects of supraphysiologic doses of testosterone on aggressive responding in a controlled laboratory setting. Eight male subjects received gradually increasing doses of testosterone cypionate (150 mg/week for two weeks, 300 mg/week for two weeks, and 600 mg/week for two weeks) or placebo using a double-blind, randomized, cross-over design. Subjects were tested both before and after the series of injections. During the experimental session subjects could press a button to accumulate points exchangeable for money (non-aggressive response) or press another button to subtract points from a fictitious opponent (aggressive response). Aggressive responding was instigated by subtracting points from the subject which was attributable to the fictitious opponent. Testosterone administration resulted in a significantly higher number of aggressive responding compared to placebo.
authors: Biological Psychiatry Laboratory, McLean Hospital/Harward Medical School, Belmont, MA 02178, USA.
authors: E M
authors: EM
authors: Kouri
authors: S E
authors: SE
authors: Lukas
authors: H G
authors: HG
authors: Pope
authors: P S
authors: PS
authors: Oliva
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects*; D045930:Anabolic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D045930:Anabolic Agents; D013739:Testosterone; C016131:testosterone 17 beta-cypionate