title: [Activated protein C resistance: role in venous and arterial thrombosis].
abstract: Activated protein C resistance is the most prevalent cause of thrombophilia: it is found in 20% to 30% of patients with a history of deep venous thrombosis history. Activated protein C resistance is due to an arginine 506 to glutamine mutation in factor V. This mutation prevents normal inactivation of activated factor V by activated protein C. The estimated increase in relative risk of venous thrombosis is 5 to 10 fold in heterozygotes, and 50- to 100- fold in homozygotes. Activated protein C resistance does not seem to play a role in arterial thrombosis or in the occurrence of myocardial infarction.
authors: Service de médecine vasculaire, centre Claude-Bernard de recherche surles maladies vasculaires périphériques, hôpital Broussais, Paris.
authors: J
authors: J
authors: Emmerich
authors: M
authors: M
authors: Alhenc-Gelas
authors: M
authors: M
authors: Aiach
authors: J N
authors: JN
authors: Fiessinger
mesh_terms: D001778:Blood Coagulation Disorders / Q000235:genetics / Q000503:physiopathology; D004351:Drug Resistance / Q000235:genetics*; D005165:Factor V / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D011486:Protein C / Q000378:metabolism / Q000494:pharmacology*; D013927:Thrombosis / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology
chemical_list: D011486:Protein C; D005165:Factor V
vernacular_title: La résistance à l'action de la protéine C activée: rôle dans la thrombose veineuse et artérielle.