[Forced stability study of ipriflavone].
Forced stability study of ipriflavone has been conducted on solid state and in solution using different chromatographic techniques (TLC, HPLC, LC-TSP-MS) for measurement and identification. In solid state effect of high temperature, UV irradiation and that of artificial daylight were studied. In solution susceptibility to hydrolysis and oxidative ability were investigated. It was found that ipriflavone is stable in solid form at high temperature and against UV and daylight irradiation. In solution at high pH (pH > or = 9) ipriflavone is hydrolized and (2-hydroxy-4-isopropoxy-phenyl)benzyl-ketone develops as the main degradation product. Using hydrogen-peroxide or alpha,alpha'-asoisobutyronitrile ipriflavone can be oxidized, developing 2,3-dihydro-2,3-oxo-ipriflavone.
Magdolna
V M
VM
Chinoin Gyógyszer-és Vegyészeti Termékek Gyára Rt., Kémiai Kutatási Osztály.
Kálmán
S
S
Imola
R
R
Tünde
E T
ET
István
H
H
D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D007529:Isoflavones / Q000737:chemistry*; D013058:Mass Spectrometry; D015394:Molecular Structure; D012996:Solutions
D007529:Isoflavones; D012996:Solutions; C018986:ipriflavone
Ipriflavon stabilitási vizsgálata forszírozott körülmények között.