Is phototherapy safe for HIV-infected individuals?
Patients infected with human immunodeficiency virus (HIV) have a high prevalence of UV radiation-responsive skin diseases including psoriasis, pruritus, eosinophilic folliculitis and eczemas. On the other hand, UV has been shown to suppress T cell-mediated immune responses and to induce activation and replication of HIV. These developments have prompted clinicians and investigators to question whether phototherapy is safe for HIV-infected individuals. We have reviewed these issues and hereby provide a summary and critique of relevant laboratory and clinical evidence.
Adams
M L
ML
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235-9069, USA.
Houpt
K R
KR
Cruz
P D
PD
D002986:Clinical Trials as Topic; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D011701:PUVA Therapy / Q000009:adverse effects; D010789:Phototherapy / Q000009:adverse effects; D012871:Skin Diseases / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*