title: Retrovirus-induced lymphoproliferative disease in mice: role of humoral immunity in perinatally exposed mice.
abstract: The mice born to female mice infected with LP-BM5 MuLV, the etiologic agent for lymphoproliferative disease and nursed for 4-6 weeks by them were less susceptible upon reinfection by i.v. transfusion of blood or plasma from infected donors with fully developed disease. Sera of 7 week or older perinatally exposed mice were capable of a complete in vitro neutralization of virus in plasma or blood from mice with fully developed disease. In contrast, sera from 3-week old perinatally exposed mice were ineffective. The neutralizing ability of the sera was drastically reduced or abrogated after their absorption with anti-mouse IgM. These observations are consistent with the notion that perinatally exposure results ina moderate form of the disease of the offspring. This perinatal infection is followed by a production of neutralizing antibodies of predominantly the IgM class that significantly alters the course of the lymphoproliferative disease and, in some instances, even prevents its development.
authors: Department of Microbiology, Toronto, Ontario, Canada.
authors: M B
authors: MB
authors: Zaleski
authors: H R
authors: HR
authors: Thacore
authors: P
authors: P
authors: Zhou
authors: S
authors: S
authors: Dubiski
authors: S
authors: S
authors: Nakeeb
authors: R K
authors: RK
authors: Cunningham
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood / Q000502:physiology*; D005260:Female; D007113:Immunity, Innate; D007112:Immunity, Maternally-Acquired; D009052:Leukemia Virus, Murine / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology* / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012192:Retroviridae Infections / Q000209:etiology / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral