title: Corynebacterium pseudotuberculosis infection in horses: 538 cases (1982-1993).
abstract: OBJECTIVE
  To describe clinical manifestations of Corynebacterium pseudotuberculosis infection in horses and to evaluate diagnostic methods for identification of this disease.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  538 horses with a diagnosis of C pseudotuberculosis infection.
  
  
  RESULTS
  Median age of horses with external abscesses was similar to that in horses with internal abscesses. Breed and sex did not appear to be associated with infection. Cases were detected during all 12 months; however, the disease was most common in the fall and early winter, with the highest incidence in September, October, and November in every year. Most horses (492/538, 91.4%) had a single episode of infection, without recurrence in subsequent years. Of 538 horses, 308 had pectoral abscesses, although infection was documented in many other anatomic locations. Forty-two horses had internal abscesses involving the abdomen or thoracic cavity. Corynebacterium pseudotuberculosis infection was readily identified by bacterial culture of aspirate samples from abscesses. The synergistic hemolysis inhibition test was useful for diagnosis of internal abscesses; however, it was unreliable for the diagnosis of external abscesses. Horses with external abscesses responded well to conventional treatment, in contrast to those with internal abscesses. The overall case fatality was low (3.9%), and was considerably lower for horses with external abscesses (0.8%) than for horses with internal abscesses (40.5%).
  
  
  CONCLUSIONS
  Serology (synergistic hemolysis inhibition titers > or = 512) is useful for diagnosis of internal abscesses, but not reliable for diagnosis in horses with external abscesses. Prognosis for horses with internal abscesses is considerably poorer than for those with external abscesses.
authors: Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
authors: M
authors: M
authors: Aleman
authors: S J
authors: SJ
authors: Spier
authors: W D
authors: WD
authors: Wilson
authors: M
authors: M
authors: Doherr
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D000818:Animals; D003354:Corynebacterium Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D016925:Corynebacterium pseudotuberculosis / Q000302:isolation & purification; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis* / Q000453:epidemiology; D006736:Horses; D015994:Incidence; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D012621:Seasons