title: [Plasma kallikrein clearance by the liver in experimental cirrhosis].
abstract: OBJECTIVE
  To study the hepatic clearance of a glycoprotein (rat plasma kallikrein) by the liver of rats with experimental decompensated cirrhosis.
  
  
  METHODS
  Cirrhosis was induced by intragastrically administration of carbon tetrachloride 520 mg/kg/week, during 16-19 weeks. After this period, each liver was isolated, exsanguinated and perfused at 37 degrees C with 10nM rat plasma kallikrein (RPK).
  
  
  RESULTS
  58% of the animals died during the treatment and the remaining developed prostration, ascites, jaundice and bleeding; at the end of the treatment period serum aminotransferases were not altered and serum albumin decreased. The liver histology showed cirrhosis. RPK clearance rate of the cirrhosis group (5.4 +/- 0.9 pmol/g liver/10 min) was significantly lower (p < 0.05) than that of the control group (13.5 +/- 2.7 pmol/g liver/10 min).
  
  
  CONCLUSIONS
  The development of cirrhosis is associated with a decreased hepatic clearance of a glycoprotein which endocytosis is mediated by a receptor.
authors: Laboratório de Hepatologia Experimental, Universidade Federal de São Paulo.
authors: C F
authors: CF
authors: de Toledo
authors: M R
authors: MR
authors: Loureiro-Silva
authors: H M
authors: HM
authors: Molina
authors: V P
authors: VP
authors: Lanzoni
authors: M
authors: M
authors: Kouyoumdjian
authors: D R
authors: DR
authors: Borges
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000008:administration & dosage*; D007610:Kallikreins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology*; D008657:Metabolic Clearance Rate; D009929:Organ Size / Q000187:drug effects; D010477:Perfusion; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002251:Carbon Tetrachloride; D007610:Kallikreins
vernacular_title: Depuração hepática da calicreína plasmática na cirrose experimental.