Possible low response of C-reactive protein production in eosinophilic pneumonia.
C-reactive protein (CRP) in the patients with eosinophilic pneumonia was examined compared with that of bacterial pneumonia. While no difference between erythrocyte sedimentation rate (ESR) in eosinophilic pneumonia (mean +/- SE: 74.5 +/- 10.6 mm/hr) and that in bacterial pneumonia (86.2 + 7.7 mm/hr) was observed, serum CRP level (3.87 +/- 1.24 mg/dL) and alpha 2-macroglobulin level (182.53 +/- 13.00 mg/dL) in eosinophilic pneumonia were lower in comparison with those in bacterial pneumonia (14.89 +/- 1.34 mg/dL, 315.65 +/- 11.54 mg/dL, respectively), suggesting that the pathogenesis of eosinophilic pneumonia might involve defective secretion of certain cytokine related to the production of acute-phase reactant proteins such as interleukin-6.
Chihara
J
J
Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Japan.
Urayama
O
O
Yasuba
H
H
Fukuda
K
K
Yamamoto
T
T
Kurachi
D
D
Nakajima
S
S
D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000096:biosynthesis* / Q000172:deficiency*; D006801:Humans; D018410:Pneumonia, Bacterial / Q000378:metabolism / Q000473:pathology; D011657:Pulmonary Eosinophilia / Q000378:metabolism* / Q000473:pathology*
D002097:C-Reactive Protein