Delayed changes in neural visinin-like calcium-binding protein gene expression caused by acute phencyclidine administration.
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.
Kajimoto
Y
Y
Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
Shirakawa
O
O
Kuno
T
T
Nishino
N
N
Nakai
H
H
D000199:Actins / Q000235:genetics; D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000187:drug effects / Q000235:genetics*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D008297:Male; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics*; D051596:Neurocalcin; D010622:Phencyclidine / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044169:Receptors, Calcium-Sensing; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
D000199:Actins; D002135:Calcium-Binding Proteins; D018691:Excitatory Amino Acid Antagonists; D009419:Nerve Tissue Proteins; D051596:Neurocalcin; D012333:RNA, Messenger; D044169:Receptors, Calcium-Sensing; C496690:Vsnl1 protein, rat; D010622:Phencyclidine