Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa.
The lineage of HIV-2-like viruses was studied in feral sooty mangabeys (SMs) by serological and genetic methods. Four feral sooty mangabeys were positive for simian immunodeficiency virus (SIV) antibodies and a new isolate, SIVsmSL92a, was obtained. Genetic analysis of gag genes showed that SIVsmSL92a was highly diverse and a distinct sequence subtype within the SIV sm/HIV-2 family. The results showed that SIVsm is the most diverse group of SIVs found thus far in a single monkey species.
Chen
Z
Z
Department of Microbiology, New York University Medical Center, NY, 10016, US
Telfer
P
P
Reed
P
P
Zhang
L
L
Getti
A
A
Ho
D D
DD
Marx
P A
PA
D000354:Africa, Western; D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D016665:Cercocebus atys / Q000821:virology*; D003001:Cloning, Molecular; D003429:Cross Reactions; D015683:Gene Products, gag / Q000737:chemistry / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000821:virology; D008253:Macaca mulatta / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012698:Serologic Tests; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000302:isolation & purification*
D015683:Gene Products, gag