Design and assessment of clinical trials on continuous infusion.
Continuous infusion of coagulation factors is becoming increasingly popular, and is mirrored by the accelerating rate of publications on this topic. However, several questions remain, particularly regarding efficacy. For this purpose, well designed trials are required. Some guidelines for such trials are presented here.
Schulman
S
S
National Hemophilia Center, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Martinowitz
U
U
D002986:Clinical Trials as Topic; D004355:Drug Stability; D005169:Factor VIII / Q000008:administration & dosage* / Q000191:economics / Q000276:immunology / Q000493:pharmacokinetics / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy; D006801:Humans; D007260:Infusion Pumps; D012107:Research Design
D005169:Factor VIII