Study of behavior of rats with gluten-induced enteropathy.
Association of different psychological and neurological disturbances with gluten intake in coeliac patients was repeatedly described. In the present study gluten-induced enteropathy was elicited in rats by prolonged intragastric administration of gliadin from birth to 10 weeks. Various neurological (contact and visual placing reactions, equilibrium on horizontal bar) and behavioral tests (open field and Morris water maze task) were used to assess the possible deficits. No substantial differences were found in the behavior of rats fed with gliadin compared with those fed with bovine serum albumin (control group). The only difference found between control and experimental rats was that gliadin-fed rats showed slightly higher emotionality in the open field test. It is concluded that prolonged application of gliadin to young rats at enteropathy-inducing dosages does not modify their behavior.
Castany
M A
MA
Department of Immunology and Gnotobiology, Czech Academy of Sciences, Prague, Czech Republic.
Stĕpánková
R
R
Tlaskalová
H
H
Turner
L F
LF
Liu
Z
Z
Bures
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002446:Celiac Disease / Q000139:chemically induced*; D005260:Female; D005903:Gliadin / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D012710:Serum Albumin, Bovine / Q000493:pharmacokinetics / Q000494:pharmacology
D012710:Serum Albumin, Bovine; D005903:Gliadin