Effect of physical activity on serum concentrations of digoxin and digitoxin.
OBJECTIVE
To study the influence of moderate physical activity on serum concentrations of digoxin, digitoxin and albumin.


METHODS
Blood samples were drawn from 10 consecutive mobile patients on digoxin and 12 patients on digitoxin therapy before and following a 10-min walking period. Digitalis serum concentrations were determined by radioimmunoassay, and albumin serum concentrations by laser nephelometry.


RESULTS
Following physical activity, digoxin serum concentrations dropped immediately to 79% of baseline values and remained significantly decreased for 20 min. Digitoxin concentrations did not change significantly.


CONCLUSIONS
In contrast to digoxin, the effect of physical activity the serum concentration of digitoxin can be disregarded.
Grille
W
W
First Medical Department, Community Hospital Kiel, Germany.
Welter
U
U
Johnsen
K
K
Kolenda
K D
KD
Löffler
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D004074:Digitoxin / Q000493:pharmacokinetics*; D004077:Digoxin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D012709:Serum Albumin / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D012709:Serum Albumin; D004077:Digoxin; D004074:Digitoxin