C-Ha-ras oncogene in oral leukoplakia tissues.
The amplification and the G-T mutation at codon 12 of the C-Ha-ras oncogene in oral leukoplakia tissues were analyzed by using polymerase chain reaction (PCR) and molecular biologic technique. The results showed that these tissues had no amplification of Ha-ras oncogene. Only one case harbored G-T mutation in 11 oral leukoplakias, but this mutation was absent in 10 normal oral mucosal tissues. The possible role and significance of C-Ha-ras oncogene in oral precancerous lesions were also discussed.
Cheng
P
P
Department of Stomatology, Tongji Hospital, Tongji Medical University, Wuhan.
Li
H
H
Yang
P
P
Tan
Y
Y
D001483:Base Sequence; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007972:Leukoplakia, Oral / Q000235:genetics*; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction