Ganglioside long-chain base composition of rat brain subcellular fractions after chronic ethanol administration.
Rats of two different ages (2 and 7 months) were treated with an ethanol-containing liquid diet for 24 days and change of the ceramide composition of gangliosides were studied in the brain synaptosomal, microsomal and myelin fractions. Greater differences were observed in the younger age, where ethanol treatment caused a significant increase of C20:1 LCB in GM1 ganglioside of synaptosomes and microsomes and in GD1a of myelin.
Omodeo-Salé
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Institute of General Physiology and Biochemistry, Faculty of Pharmacy, University of Milan, Italy.
Gornati
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Palestini
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D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure*; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005732:Gangliosides / Q000737:chemistry*; D008297:Male; D008861:Microsomes / Q000737:chemistry / Q000187:drug effects; D009186:Myelin Sheath / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013347:Subcellular Fractions / Q000737:chemistry* / Q000187:drug effects; D013574:Synaptosomes / Q000737:chemistry / Q000187:drug effects
D002518:Ceramides; D005732:Gangliosides; D000431:Ethanol