Effect of some parasitic infection on neurotransmitters in the brain of experimentally infected mice before and after treatment.
The effects of some parasitic infection (bilharziasis, toxocariasis and trichinosis) on the brain of experimentally infected mice were investigated. Eighty animals were classified into four groups, group I contained five non infected animals as a control group. The other groups each contained twenty-five mice infected with Schistosoma mansoni (group II), Toxocara canis (group III) and Trichinella spiralis (group IV). Each infected group was divided into two subgroups (a,b). Subgroup (a) left untreated and subgroups (b) treated by praziquantel (in group II) and mebendazole (in group III and IV). Histopathological and immunological examination using peroxidase antiperoxidase (PAP) technique and neurotransmitters estimation (nor-epinephrine, dopamine and serotonine) were carried. In the untreated animals, there were mild histopathological changes and mild antigenic deposition in subgroups (IIa and IIIa) and marked changes in subgroup (IVa). There were significant decrease in dopamine in subgroup (IIIa), not improved after treatment (subgroup IIIb) and significant decrease in nor-epinephrine and serotonine in subgroup (IVa) improved after treatment in subgroup (IVb). The neurotransmitters changes may explain the motor, behavioural and emotional changes that occurred with these parasites.
Abdel Ghafar
A E
AE
Department of Parasitology, Faculties of Medicine and Pharmacy, Tanta University, Egypt.
Elkowrany
S E
SE
Salem
S A
SA
Menaisy
A A
AA
Fadel
W A
WA
Awara
W M
WM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D004298:Dopamine / Q000378:metabolism; D008463:Mebendazole / Q000627:therapeutic use*; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010272:Parasitic Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D011223:Praziquantel / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism; D017166:Toxocara canis; D014120:Toxocariasis / Q000188:drug therapy / Q000503:physiopathology; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000188:drug therapy / Q000503:physiopathology
D018377:Neurotransmitter Agents; D012701:Serotonin; D011223:Praziquantel; D008463:Mebendazole; D004298:Dopamine; D009638:Norepinephrine