huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system.
huckebein encodes a predicted zinc finger transcription factor which is transiently expressed in a subset of Drosophila central nervous system precursors (neuroblasts (NBs)). We used DiI cell lineage tracing and cell fate markers to investigate the role of huckebein in the NB 1-1 and NB 2-2 cell lineages. Loss of huckebein does not switch these NBs into different NB fates, nor does it change the number of cells in their lineages; rather, it is required for glial development in the NB 1-1 lineage, and for axon pathfinding of a subset of interneurons and motoneurons in both lineages.
Bossing
T
T
Institut für Genetik, Universität Mainz, Germany.
Technau
G M
GM
Doe
C Q
CQ
D000818:Animals; D001369:Axons / Q000502:physiology*; D002460:Cell Line; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology; D004268:DNA-Binding Proteins / Q000502:physiology*; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D009457:Neuroglia / Q000502:physiology*; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C087725:Hkb protein, Drosophila