The use of low-dose intravenous insulin in clinical myocardial F-18 FDG PET scanning.
The effectiveness of low-dose intravenous insulin boluses to improve study quality in F-18 FDG myocardial scans is investigated. Seventeen patients were imaged using a protocol in which only diabetic patients with fasting blood glucose levels > 8 mmol/l were given insulin. Fifty-three patients were imaged using a protocol in which all patients were given 1-3 IU intravenously of insulin immediately before F-18 FDG injection, based on fasting blood glucose levels. Scan quality was rated as poor, good, or excellent. Using the conventional protocol, 29% of the scans were poor quality (uniterpretable), 47% were good, and 23% were excellent. Using the low-dose intravenous insulin boluses protocol; 2% were poor, 53% were good, and 45% were excellent (P = 0.01). There were no significant differences in the proportion of diabetic patients, age, or fasting blood glucose levels. Low-dose intravenous insulin bolus is an easy and safe method of improving myocardial F-18 FDG scan quality in nondiabetic and diabetic patients.
Lewis
P
P
Guy's and St. Thomas' Clinical PET Centre, London, United Kingdom.
Nunan
T
T
Dynes
A
A
Maisey
M
M
D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D007328:Insulin; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose