Propofol influences the electroretinogram to a lesser degree than thiopentone.
BACKGROUND
The Electroretinogram (ERG) is used clinically to assess the function of retina. Anaesthetic agents are known to affect ERG, and as anaesthesia is often needed in children and uncooperative patients, knowledge about its effects is of clinical importance. Barbiturates selectively depress ERG components, and we compared thiopentone with propofol to assess if the latter preserved retinal function better.


METHODS
Ten pigs, average weight 17 kg (SD +/- 2 kg) were anaesthetized randomly with propofol 10 mg kg-1 or thiopentone 30 mg kg-1. Anaesthesia was maintained by 65% nitrous oxide in oxygen and continuous infusion of the induction agent, i.e. 10 mg kg-1 h-1 of propofol, or 10 mg kg-1 h-1 for the first hour, then 5 mg kg-1 h-1 of thiopentone, with doses being based on pilot studies. After an interval of one week the programme was repeated using the other agent. After 40 minutes dark-adaptation, responses to single flashes of graded intensities from a xenon flashlamp were recorded at five-minute intervals. The a- and b-wave amplitudes and implicit times (time to peak), and a-wave slopes were determined.


RESULTS
The b-wave implicit time was significantly shorter during propofol anaesthesia than when using thiopentone. The effect was most pronounced at the lowest intensities (P < 0.01). No statistically significant differences were found in the amplitudes of the b-waves. The a-wave appeared at lower stimulus intensity (P < 0.05) and the a-wave slopes were significantly steeper (P < 0.01) during propofol anaesthesia.


CONCLUSIONS
Propofol accordingly appeared to preserve the photoreceptor response better than thiopentone, and may therefore be considered to be more suitable for ERG recordings than thiopentone.
Tanskanen
P
P
Department of Anaesthesia at Töölö Hospital, Helsinki University Central Hospital, Finland.
Kylmä
T
T
Kommonen
B
B
Karhunen
U
U
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D004596:Electroretinography / Q000187:drug effects*; D010786:Photoreceptor Cells / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology*; D013552:Swine; D013874:Thiopental / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol