Gamma delta + T cells in Wilson's disease.
Little is currently known about the role of gamma delta + T cells in disease pathogenesis. We have demonstrated elevated levels of gamma delta + T cells in the peripheral blood and cerebrospinal fluid of patients with Wilson's disease compared with other neurological diseases. The percentage of V delta 1 +/ gamma delta + T cells was between 20% and 50% in all patient groups; gamma delta + T cells in blood correlated with copper concentrations. The antigen reactivity of gamma delta + T cells and how the antigens relate to the gamma delta + T cells found in WD remains unknown. It remains unclear whether there is a direct reason for the elevated gamma delta + T cells population found in WD. Immunohistochemistry of frozen autopsy material from brain and liver of WD patients could allow exact localization of gamma delta + T cells and heat shock proteins in future studies.
Fiszer
U
U
II Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.
Korczak-Kowalska
G
G
Gajda
J
J
Korlak
J
J
Górski
A
A
Członkowska
A
A
D000328:Adult; D005260:Female; D005434:Flow Cytometry; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta