Immunologic effects of encapsulated short ragweed extract: a potent new agent for oral immunotherapy.
BACKGROUND
Oral allergen immunotherapy with conventional allergens has not been a useful mode of treatment because of the lack of potency of allergens when administered by this route.


OBJECTIVE
To study the immunologic potency of short ragweed pollen extracts microencapsulated by a new technique administered orally to short ragweed pollen-sensitive humans and to establish the dose of oral microencapsulated short ragweed pollen extract required for these effects.


METHODS
Nine short ragweed pollen-sensitive patients were treated with a new oral agent for immunotherapy, microencapsulated short ragweed pollen extract, in an open study. The effectiveness of this treatment was determined by comparison to a group of nine matched short ragweed pollen-sensitive patients who received no treatment. Treated patients developed high titers of short ragweed-specific IgG and IgE antibodies and their expected seasonal increase in IgE antibodies was regulated. The dose of microencapsulated short ragweed pollen extract required to achieve these effects was only slightly higher than the dose of short ragweed pollen extract used in high dose subcutaneous immunotherapy. Furthermore, this dose was achieved in 7 weeks. There were no side effects other than mild gastrointestinal ones. The nine treated patients fared clinically better during the ragweed season than the untreated patients in this open study.


CONCLUSIONS
This study suggests that allergens microencapsulated by this new technique may make oral immunotherapy a practical mode of treatment.
Litwin
A
A
Department of Molecular Genetics, College of Medicine, University of Cincinnati, Ohio, USA.
Flanagan
M
M
Entis
G
G
Gottschlich
G
G
Esch
R
R
Gartside
P
P
Michael
J G
JG
D000328:Adult; D000485:Allergens / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D003888:Desensitization, Immunologic / Q000379:methods*; D004306:Dose-Response Relationship, Immunologic; D004339:Drug Compounding / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007700:Kinetics; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*
D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007073:Immunoglobulin E