Chromosomal abnormalities in neutron-induced acute myeloid leukemias in CBA/H mice.
Acute myeloid leukemias (AMLs) induced in CBA/H mice by 1 MeV fission neutrons have been examined for chromosomal abnormalities by G-band analysis. In common with X-ray- and alpha-particle-induced AMLs in CBA/H mice, more than 90% (16/17) of the myeloid leukemias had chromosome 2 abnormalities, in this case, all interstitial deletions. Chromosome 2 breakpoints were not wholly consistent, but clustering in three specific G-band regions was observed. Very distal (H-region) breakpoints were more common in the neutron AMLs than in X-ray- or alpha-particle-induced leukemias. These data indicate that neutron-induced AMLs in CBA/H mice are not characterized by a specific chromosome deletion but that a variety of chromosome 2 deletion types are associated with the disease. Trisomy of chromosome 1(12.5% AMLs) and aneusomy of chromosomes 6 (31% AMLs) and Y (37.5% AMLs) were noted. While chromatid breakage was observed occasionally in neutron-induced AML, no clear indications of persistent chromosomal instability or high levels of stable chromosomal change were apparent.
Bouffler
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SD
Biomedical Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxon, United Kingdom.
Meijne
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EI
Huiskamp
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Cox
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R
D000208:Acute Disease; D000818:Animals; D002842:Chromatids / Q000528:radiation effects; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002875:Chromosomes / Q000528:radiation effects; D005214:Fast Neutrons; D007951:Leukemia, Myeloid / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D014314:Trisomy; D014501:Uranium
D014501:Uranium