The effects of sulfur dioxide inhalation and antioxidant vitamins on red blood cell lipoperoxidation.
An attempt was made to determine whether sulfur dioxide (SO2,) inhalation at 10 ppm, 1 hr daily, for 30 days induces oxidant stress and whether vitamin E (40 mg/kg) together with vitamin C (200 mg/kg), administered intraperitoneally once in every 3 days, can reduce the damage in red blood cell membranes of guinea pigs. Malonyldialdehyde (MDA) levels, osmotic fragility ratios, and methemoglobin and sulfhemoglobin values were significantly higher in the SO2-treated group compared with the control group (P < 0.05), and marked decreases in MDA levels and osmotic fragility ratios were determined in the group treated with SO2 + antioxidant vitamins (P < 0.05).
Etlik
O
O
Department of Physiology, Faculty of Medicine, Gulhane Military Medical Academy, Ankara, Turkey.
Tomur
A
A
Kutman
M N
MN
Yörükan
S
S
Duman
O
O
D000280:Administration, Inhalation; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D013458:Sulfur Dioxide; D014810:Vitamin E; D008315:Malondialdehyde; D001205:Ascorbic Acid