Apoptosis of lymphocytes in mice induced by infection with Rickettsia tsutsugamushi.
Histological examinations of mice infected with either a lethal (Karp) or a self-limitating (Gilliam) strain of Rickettsia tsutsugamushi were performed. Tingible body macrophages in the spleen and necrotizing lymphadenitis in regional lymph nodes were prominent only in the former. Apoptotic legions in the lymphocytes of these organs were clearly demonstrated by histochemical and electron microscopical examinations.
Kasuya
S
S
Department of Parasitology, Gifu University School of Medicine, Japan.
Nagano
I
I
Ikeda
T
T
Goto
C
C
Shimokawa
K
K
Takahashi
Y
Y
D000818:Animals; D017209:Apoptosis; D004247:DNA / Q000737:chemistry; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology*; D008264:Macrophages / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D012285:Orientia tsutsugamushi / Q000276:immunology*; D012612:Scrub Typhus / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000166:cytology
D004247:DNA