Subretinal tumour in a patient with a limited form of Wegener's granulomatosis.
In 1939 F. Wegener published a report concerning a peculiar febrile syndrome with necrotizing inflammation of the upper respiratory tract, focal glomerulonephritis and systemic angiitis (Wegener 1939). Clinically Wegener's granulomatosis can be divided into a limited and a generalized form. We describe a patient presenting with unilateral ocular symptoms suspicious of a neoplasm, one episode of angina pectoris and general malaise without any clinical signs of upper respiratory tract involvement. Before Wegener's granulomatosis was diagnosed by a positive titre of antineutrophil cytoplasmic antibodies and open lung biopsy, immunoscintigraphy for malignant melanoma showed a false positive result. Systemic treatment with corticosteroids and cyclophosphamide resulted in an improvement of the ocular symptoms within weeks.
Agostini
H T
HT
Klinikum der Albert-Ludwigs-Universität, Augenklinik, Freiburg, Germany.
Bräutigam
P
P
Löffler
K U
KU
D019268:Antibodies, Antineutrophil Cytoplasmic; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005654:Fundus Oculi; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology; D015609:Organotechnetium Compounds; D011239:Prednisolone / Q000627:therapeutic use; D012164:Retinal Diseases / Q000175:diagnosis* / Q000188:drug therapy; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D019268:Antibodies, Antineutrophil Cytoplasmic; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D001323:Autoantibodies; D015415:Biomarkers; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D015609:Organotechnetium Compounds; D003520:Cyclophosphamide; D011239:Prednisolone