Sub-Saharan influence on the Canary Islands population deduced from G6PD gene sequence analysis.
In a screening of glucose-6-phosphate dehydrogenase (G6PD) A variants in the Canary Islands and northwest African populations by electrophoresis and posterior gene sequencing, the common A+ 376G and A- 202A/376G and the rare A- 376G/968C mutations were found. In addition, three new silent C-->T transitions have been detected at nucleotides 759 (exon 7), 1338 (exon 11), and 1573 (exon 13). Canary Island and North African samples share sub-Saharan haplotypes with Equatorial Guineans. The slave trade seems the most probable origin of the African haplotypes found in the Canary Islands.
Pinto
F M
FM
Departamento de Genetica, Facultad de Biología, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
González
A M
AM
Hernández
M
M
Larruga
J M
JM
Cabrera
V M
VM
D017954:Africa South of the Sahara / Q000208:ethnology; D004252:DNA Mutational Analysis; D016703:Equatorial Guinea / Q000208:ethnology; D005787:Gene Frequency; D014644:Genetic Variation; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D008297:Male; D009018:Morocco / Q000208:ethnology; D011110:Polymorphism, Genetic; D013030:Spain
D005954:Glucosephosphate Dehydrogenase