title: Species differences in the localization of neuropeptide FF receptors in rodent and lagomorph brain and spinal cord.
abstract: Quantitative in vitro receptor autoradiography of [125I][D-Tyr1,(NMe)Phe3]NPFF was used to study the regional distribution of neuropeptide FF receptors in rodent and lagomorph brain. In rat, mouse, rabbit, and Afghan pika [125I][D-Tyr1,(NMe)Phe3]NPFF binding sites were enriched in the superficial layers of dorsal horn of the spinal cord and in parabrachial nucleus, central gray matter, hypothalamus, and reunions thalamic nucleus. In other neuroanatomical regions, important species differences in NPFF receptor patterns are observed. In marked contrast, the brain and the spinal cord of the Octodon degus are devoid of NPFF receptors. The present study shows that in different species regional variations in brain NPFF receptor binding occur.
authors: Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS, Toulouse, France.
authors: V
authors: V
authors: Dupouy
authors: A
authors: A
authors: Puget
authors: A
authors: A
authors: Eschalier
authors: J M
authors: JM
authors: Zajac
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002490:Central Nervous System / Q000737:chemistry*; D006624:Hippocampus / Q000737:chemistry; D007793:Lagomorpha / Q000502:physiology*; D008297:Male; D051379:Mice; D015335:Molecular Probes; D009830:Olfactory Bulb / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D018013:Receptors, Neuropeptide / Q000302:isolation & purification*; D012377:Rodentia / Q000502:physiology*; D013045:Species Specificity; D013116:Spinal Cord / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D015335:Molecular Probes; D009842:Oligopeptides; D018013:Receptors, Neuropeptide; C083929:neuropeptide FF receptor; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide