Mammary tumors induced by human adenovirus type 9: a role for the viral early region 4 gene.
Human adenovirus type 9 (Ad9) elicits exclusively estrogen-dependent mammary tumors when injected into female rats. Three different histological types of mammary tumor (benign fibroadenomas, phyllodes tumors, and malignant solid sarcomas) have been described in Ad9-infected animals, with benign fibroadenomas being seen most frequently. Interestingly, in contrast to other adenoviruses, in which oncogenic viral functions are entirely encoded within the E1 region, Ad9 requires an E4 region transforming protein (ORF1) for its unique mammary oncogenicity. Studies of Ad9-induced rat mammary tumors may lead to a detailed molecular understanding for the development of fibroadenoma, a common human breast tumor.
Javier
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Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA.
Shenk
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T
D000260:Adenoviruses, Human / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000378:metabolism; D004967:Estrogens / Q000502:physiology; D005260:Female; D018226:Fibroadenoma / Q000473:pathology / Q000821:virology; D015967:Gene Expression Regulation, Viral; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004279:DNA, Viral; C101120:E4 protein, Adenovirus 9; D004967:Estrogens; D009856:Oncogene Proteins, Viral; D012333:RNA, Messenger