Minocycline-induced liver injury.
Tetracycline may cause fatty infiltration of the liver; more recently, it has been reported to cause intrahepatic cholestasis with bile duct depletion. However, minocycline, a derivative of tetracycline, is not generally recognized to be hepatotoxic. We report a series of six cases of presumed minocycline-induced liver injury; five of these patients had acute hepatitic illness, whereas one had a more prolonged course with histological evidence of chronic hepatitis. In addition, three patients demonstrated abnormal anti-nuclear antibody levels, and one had positive double-stranded DNA.
Malcolm
A
A
Department of Gastroenterology, Royal North Shore Hospital, Sydney, Australia.
Heap
T R
TR
Eckstein
R P
RP
Lunzer
M R
MR
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D056487:Chemical and Drug Induced Liver Injury, Chronic; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D008911:Minocycline