[Progression of viral infection in twins born from a mother infected with human immunodeficiency virus].
We studied the evolution of HIV-1 infection and immune response during six years in two twins born from an infected mother. The children had a continuous progression of the infection, proved by CD4+ cell count, serum anti-HIV antibodies, cultivable virus and proviral load. Now, both children are on antiviral treatment. The analysis of serum antibodies showed a different immune response in both children. One of them developed higher levels of antibodies directed against viral proteins and synthetic peptides derived from their aminoacid sequence. In this child, the amount of cultivable virus increased less than in his twin. Nucleotide sequencing of a part of viral genoma, showed that the virus belonged to the B subtype, prevalent in America and Europe. The observed differences in viral sequences suggest a different selective pressure in both twins. This phenomenon could be related to the observed differences in immune response.
Gaggero
A
A
Departamento de Microbiología, Universidad de Chile, Santiago.
Escanilla
D
D
Larrañaga
C
C
Uribe
P
P
Espejo
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology* / Q000628:therapy / Q000635:transmission; D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D018791:CD4 Lymphocyte Count; D002675:Child, Preschool; D004200:Diseases in Twins / Q000209:etiology* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D016679:Genome, Viral; D015483:HIV Antibodies / Q000097:blood*; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008969:Molecular Sequence Data; D013997:Time Factors
D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120
Progreso de la infección viral en mellizos hijos de madre infectada por el virus de la inmunodeficiencia humana.