title: Allogenic peripheral blood stem cell (PBSC) transplantation in two patients with graft failure.
abstract: Allogenic peripheral blood stem cells (PBSC) were used for graft failure after BMT in two patients. These PBSC were mobilized by G-CSF in the same donors, harvested and given without reconditioning to the patients. In one patient, PBSC with a very high T cell number were given unprocessed, in the other patient, CD34+ cells were positively enriched due to a 2-antigen difference. None of the patients had hyperacute GVHD. Trilineage engraftment was seen after 13 days. Acute GVHD grade II to III developed on days +31 in patient 1 and +16 in patient 2, involving predominantly gut and liver, but sparing the skin. Thus, allogeneic PBSCT for graft failure did not cause hyperacute GVHD even with very high T cell numbers in patient 1, and graft failure with CD34 selected PBSC was successfully reversed even with a low number of T cells in patient 2.
authors: Dr von Haunersches Kinderspital, University of Munich, Germany.
authors: D
authors: D
authors: Stachel
authors: I
authors: I
authors: Schmid
authors: C
authors: C
authors: Straka
authors: R
authors: R
authors: Handgretinger
authors: H J
authors: HJ
authors: Kolb
authors: R J
authors: RJ
authors: Haas
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D014184:Transplantation, Homologous