title: Endocrine neoplasia in New World primates.
abstract: Of 1,106 New World primates necropsied from the National Zoological Park (Washington, D.C.) and the Department of Comparative Pathology, Johns Hopkins University School of Medicine (Baltimore, Maryland) 22 (1.9%) animals were identified with 27 neoplasms. Of this group, nine animals (two females, seven males) had a total of 13 endocrine neoplasms. All animals were adults, with an age range of 2.7-25 years (average, 12.1 years). Seven were Callitrichidae and two were Cebidae. The adrenal gland was the most affected organ, with seven (53.8%) neoplasms, followed by the pituitary and thyroid gland with two (15.4%) cases each, and the pancreas and parathyroid gland with one tumor (7.7%) each. All neoplastic disorders were benign. Immunocytochemistry assays for growth hormone, adrenocorticotropic hormone, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, and chromogranin A were performed on two pituitary neoplasms. Pheochromocytoma was the most frequent neoplasm, representing 5 (38.4%) of the 13 neoplasms. The remaining were thyroid cystadenoma (two, 15.4%), corticotrophic cell pituitary adenoma (two, 15.4%), adrenal ganglioneuroma (one, 7.7%), adrenal cortical adenoma (one, 7.7%), parathyroid chief-cell adenoma (one, 7.7%), and pancreatic islet-cell adenoma (one, 7.7%).
authors: Department of Pathology, Faculty of Veterinary Medicine, University of São Paulo, Brazil.
authors: J L
authors: JL
authors: Dias
authors: R J
authors: RJ
authors: Montali
authors: J D
authors: JD
authors: Strandberg
authors: L K
authors: LK
authors: Johnson
authors: M J
authors: MJ
authors: Wolff
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000662:veterinary; D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000662:veterinary; D000818:Animals; D002144:Callithrix; D002427:Cebidae; D003537:Cystadenoma / Q000473:pathology / Q000662:veterinary; D004701:Endocrine Gland Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005729:Ganglioneuroma / Q000473:pathology / Q000662:veterinary; D008297:Male; D010282:Parathyroid Neoplasms / Q000473:pathology / Q000662:veterinary; D010673:Pheochromocytoma / Q000473:pathology / Q000662:veterinary; D010911:Pituitary Neoplasms / Q000473:pathology / Q000662:veterinary; D018419:Primate Diseases; D012452:Saguinus; D013964:Thyroid Neoplasms / Q000473:pathology / Q000662:veterinary