The effect on body temperature and melatonin of a 39-h constant routine with two different light levels at nighttime.
Eight healthy subjects were studied during 39-h spans (from 07:00 on one day until 22:00 the second) in which they remained awake. During one experiment, subjects were exposed to 100 lux of light between 18:00 and 8:00, and during a second experiment, they were exposed to 1000 lux during the same time span. Throughout the daytime period, they were exposed to normal daylight (1500 lux or more). The nighttime 1000-lux light treatment suppressed the melatonin metabolite aMT6s, while the 100 lux treatment did not. On the treatment day, the 1000 lux, in comparison to the 100 lux, light treatment resulted in both an elevated temperature minimum and a delay in its clock-time occurrence overnight. No real circadian phase shift in the temperature, urinary melatonin, or cortisol rhythms was detected after light treatment. This study confirmed that nocturnal exposure to lower light intensities is capable of modifying circadian variables more than previously estimated. The immediate effects of all-night light treatment are essentially not different from those of evening light. This may be important if bright light is used to improve alertness of night workers. Whether subsequent daytime alertness and sleep recovery are affected by the protocol used in our study remains to be determined.
Foret
J
J
Laboratoire d'Etude du Sommeil Unité 296 INSERM, Hôpital Henri-Mondor, Créteil, France.
Daurat
A
A
Touitou
Y
Y
Aguirre
A
A
Benoit
O
O
D000328:Adult; D001831:Body Temperature / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D004780:Environment, Controlled; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008027:Light; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D010507:Periodicity
C054513:6-sulfatoxymelatonin; D008550:Melatonin; D006854:Hydrocortisone