Multiple endocrine neoplasia type 1 associated with spinal ependymoma.
A 51-year-old man was hospitalized with a gait disturbance and hypoesthesia below the level of his chest. These symptoms were due to a spinal tumor which was surgically resected and identified as an ependymoma. Additionally, the patient had hypercalcemia and a family history of insulinoma. An endocrine evaluation revealed parathyroid hyperplasia and a pancreatic islet cell tumor. Magnetic resonance imaging disclosed a pituitary microadenoma. He was diagnosed with spinal ependymoma and multiple endocrine neoplasia type 1 (MEN 1). A review of the literature revealed that chromosome 11q13 abnormalities have been reported in both ependymoma and MEN 1. We discuss the pathogenesis of these diseases.
Kato
H
H
Third Department of Internal Medicine, School of Medicine, Tokyo Medical.
Uchimura
I
I
Morohoshi
M
M
Fujisawa
K
K
Kobayashi
Y
Y
Numano
F
F
Goseki
N
N
Endo
M
M
Tamura
A
A
Nagashima
C
C
D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D004806:Ependymoma / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010375:Pedigree; D013125:Spinal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000235:genetics