Apolipoprotein E as a risk factor for coronary heart disease: a genetic and molecular biology approach.
For a long time it has been suggested that apolipoprotein E4 is a major risk factor for coronary heart disease although indisputable proof has been lacking. However, context-dependent influences of apolipoprotein E polymorphism on the risk for coronary heart disease have been reported; that is, depending on ethnic origin, gender and lifestyle, apolipoprotein E4 confers a major risk factor for coronary heart disease.
de Knijff
P
P
MGC-Department of Human Genetics, Leiden University, The Netherlands.
Havekes
L M
LM
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013045:Species Specificity
D001057:Apolipoproteins E; D002784:Cholesterol