[The role of adoptive immunotherapy in the combined treatment of neglected forms of colorectal cancer (a preliminary report)].
Results of treatment of 24 patients with neglected colorectal tumors in the period from 1988 till 1994 are presented. Six patients had stage C and 18 patients had stage D after Dukes. Methods of combined action on the tumor including dissection of the tumor and its metastases, using immunoadoptive therapy as extracorporal connection with the donor porcine spleen, intravenous infusions of interleukin-2 and chemotherapy were employed. All the patients with stage C according to Dukes are alive: the average period of observations was 1143 +/- 206 days with intervals within the limits of 4,5-1,5 years. Seven patients of 18 with stage D after Dukes are alive with the average period of observations 1331 +/- 216 days and an interval of observations within the limits from 6 to 2 years. Dead patients with stage D after Dukes lived 525 +/-98 days on the average, i.e. about 1,4 year. The employed method of combined treatment of colorectal tumors improves survival, prolongs the lifetime of patients with neglected forms of the disease.
Grinev
M V
MV
Gromov
M I
MI
Masiianskaia
T I
TI
Pivovarova
L P
LP
Razumova
N K
NK
Tarelkina
M N
MN
Frolov
G M
GM
Tsibin
Iu N
IuN
Shirokov
D M
DM
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011182:Postoperative Care; D013997:Time Factors
Rol' adoptivnoĭ immunoterapii v kombinirovannom lechenii zapushchennykh form kolorektal'nogo raka (predvaritel'noe soobshchenie).