title: [Overexpression of c-Fos induces apoptosis of CD43+ pro-B cells].
abstract: The proto-oncogene product c-Fos, a component of the transcription factor AP-1, is induced in early B lineage cells. In order to investigate a role of the c-Fos in early B cell development, fetal liver (FL) cells from transgenic mice carrying an IFN-inducible c-fos gene (Mx-c-fos) were cultured on a stromal cell layer with IL-7. The development was perturbed by the addition of IFN at the beginning of culture. When IFN was added in the FL culture after B lineage cells developed, pro-B (B220+, CD43+) cells were selectively dying by apoptosis within 48 h after IFN stimulation. These results suggest that c-Fos plays a causal role in deletion of pro-B cells.
authors: Division of Developmental Genetics, Chiba University School of Medicine.
authors: L
authors: L
authors: Hu
authors: T
authors: T
authors: Tokuhisa
mesh_terms: D000818:Animals; D015703:Antigens, CD; D017209:Apoptosis / Q000235:genetics; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D002455:Cell Division; D051917:Leukosialin; D051379:Mice; D016760:Proto-Oncogene Proteins c-fos / Q000502:physiology*; D012795:Sialoglycoproteins; D014157:Transcription Factors
chemical_list: D015703:Antigens, CD; D051917:Leukosialin; D016760:Proto-Oncogene Proteins c-fos; D012795:Sialoglycoproteins; C497863:Spn protein, mouse; D014157:Transcription Factors