Lipid-lowering treatment: effects on endothelial dysfunction.
An association has been demonstrated between the extent of atherosclerotic involvement and vasodilatory capacity in coronary and cerebral circulation. Impairment of endothelium-dependent relaxation is inversely related to HDL concentrations in plasma. Angiographic studies in humans have shown improved vasodilation capacity of the coronary arteries after lipid-lowering treatment.
Rubba
P
P
Institute of Internal Medicine and Diseases of Metabolism, Medical School, Federico II University, Naples, Italy.
Mancini
M
M
D000818:Animals; D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use; D002560:Cerebrovascular Circulation; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000503:physiopathology; D003326:Coronary Circulation; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
D000960:Hypolipidemic Agents; D008055:Lipids; D008075:Lipoproteins, HDL; D001120:Arginine