[The effect of multiple administrations of GABA and bicuculline into the rat neostriatum on the realization of a food-acquisition habit].
The effects of three-week daily intrastriatal GABA (45 mcg) and bicucullin (5 mcg) microinjections on operant performance in the Skinner's box were studied in rats. GABA was shown to facilitate the operant responses (the rate of lever pressings increased, spontaneous motor activity became optimized). Bicucullin produced the opposite effects, i.e., the operant skill practically disappeared at the second-third week of injections. The operant behaviour was substantially influences by such factors as neurosurgery trauma, narcosis, and injections as demonstrated in control experiments. The findings suggest the involvement of GABAergic neostriatal system in realization of conditioned motor alimentary behaviour.
Iakimovskiĭ
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D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology*; D008297:Male; D008845:Microinjections / Q000379:methods; D017072:Neostriatum / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
D018756:GABA Antagonists; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
Vliianie mnogokratnykh vvedeniĭ GAMK i bikukullina v neostriatum krys na realizatsiiu pishchedobyvatel'nogo navyka.