Reticuloendothelial system function in acute liver injury induced by D-galactosamine.
OBJECTIVE
Reticuloendothelial system function, as assessed by clearance of radiolabelled bacteria, was evaluated in acute liver injury induced by D-galactosamine in rats, and compared with that after 70% liver resection model.


RESULTS
Reticuloendothelial system function was significantly impaired in both instances, but the extent and the pattern of reticuloendothelial system impairment differed in the two models. While the elimination rate of the radiolabelled bacteria (k-value) decreased in both the liver resection and D-galactosamine groups (19% and 52%, respectively), the corrected phagocytic index (alpha) increased in 70% liver resection (247%), indicatine increased activity among the remaining reticuloendothelial system cells of the liver. Estimation of subserosal organ blood flow showed decreased flow to the cecum and distal small intestine (correction of intesting) in both groups, whereas it was significantly increased (477%) in the remaining parts of the liver in the liver resection group.


CONCLUSIONS
These findings show that reticuloendothelial system activity is deranged in both these groups, which may explain the increased occurrence of bacterial complications observed in corresponding clinical conditions.
Kasravi
F B
FB
Department of Surgery, Lund University Hospital, Sweden.
Wang
X
X
Guo
W
W
Andersson
R
R
Norgren
L
L
Jeppsson
B
B
Bengmark
S
S
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D018407:Bacterial Physiological Phenomena; D005688:Galactosamine / Q000633:toxicity*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects*; D008102:Liver Circulation; D008297:Male; D012157:Mononuclear Phagocyte System / Q000503:physiopathology*; D010587:Phagocytosis; D051381:Rats; D017207:Rats, Sprague-Dawley
D005688:Galactosamine