Serum therapy for Cryptococcal meningitis.
Three patients were treated with combined amphotericin B and rabbit anticryptococcal antibody in the 1960s. Rabbit antibody was administered intravenously and was well tolerated. For each patient, administration of rabbit antibody resulted in the appearance of serum Cryptococcus neoformans agglutinins. For two patients the administration of rabbit antibody resulted in negative serum latex tests for cryptococcal antigen. This limited experience with adjunctive antibody therapy provides valuable precedents if antibody therapy is used again for treatment of human cryptococcosis.
Gordon
M A
MA
Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Casadevall
A
A
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000907:Antibodies, Bacterial / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000503:physiopathology / Q000628:therapy*; D008875:Middle Aged; D011817:Rabbits
D000907:Antibodies, Bacterial; D000935:Antifungal Agents; D000666:Amphotericin B