title: The effect of surgical castration on lipid metabolism in premenopausal and postmenopausal women.
abstract: OBJECTIVE
  To investigate the effect of endogenous estrogen on lipid and lipoprotein metabolism in premenopausal and postmenopausal women.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  Department of Obstetrics-Gynecology, Beilinson Medical Center and Tel-Aviv University Medical School, Israel.
  
  
  METHODS
  Twenty-seven women, 15 premenopausal and 12 postmenopausal, undergoing surgical castration (total abdominal hysterectomy and bilateral salpingo-oophorectomy).
  
  
  METHODS
  Blood samples were drawn before the surgical intervention and after a 6-month interval.
  
  
  METHODS
  Assays were performed for estradiol, luteinising hormone and follicle-stimulating hormone, and triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and total cholesterol/HDL as well as HDL/LDL ratio.
  
  
  RESULTS
  No significant differences were found in both groups, before castration and after 6 months. A modest, but statistically significant, rise in triglycerides was observed in the premenopausal group.
  
  
  CONCLUSIONS
  The serum lipid and lipoprotein profile encountered in premenopausal and postmenopausal women were unchanged 6 months after surgical castration. The clinical significance indicates that the effect of endogenous estrogen on lipid metabolism is doubtful and should be further investigated.
authors: Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah-Tikva, Israel.
authors: G A
authors: GA
authors: Goldman
authors: A
authors: A
authors: Schoenfeld
authors: M
authors: M
authors: Royburt
authors: L
authors: L
authors: Zeldin
authors: B
authors: B
authors: Kaplan
authors: J
authors: J
authors: Ovadia
mesh_terms: D000328:Adult; D000368:Aged; D004967:Estrogens / Q000502:physiology*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause / Q000097:blood*; D011184:Postoperative Period; D017697:Premenopause / Q000097:blood*; D011446:Prospective Studies
chemical_list: D004967:Estrogens; D008055:Lipids