The effects of thiotepa, mitomycin C, BCG and interferon instillation on urothelium.
The effects of Thiotepa, Mitomycin C, BCG and Interferon on urothelium were researched in rabbits. Early changes of a contracted bladder such as fibroblastic atypia and sub-epithelial plaque were seen in all groups in different rates. This rate in the Thiotepa and BCG groups was 100% and in the Mitomycin C and Interferon groups 60%. There was no urothelial dysplasia in the BCG and Interferon groups, whereas in the Thiotepa group 100% and in the Mitomycin C group 40% were seen. In conclusion, urothelial dysplasia or fibroblastic atypia in random biopsies were criteria to prevent further complications in intravesical therapies.
Polat
O
O
Department of Urology, Atatürk University School of Medicine, Research Hospital, Erzurum, Turkey.
Gündoğdu
C
C
Demirel
A
A
Bayraktar
Y
Y
Gül
O
O
Ozbilge
M
M
D000283:Administration, Intravesical; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001500:BCG Vaccine / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D007372:Interferons / Q000494:pharmacology*; D016685:Mitomycin / Q000494:pharmacology*; D011817:Rabbits; D013852:Thiotepa / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology
D000970:Antineoplastic Agents; D001500:BCG Vaccine; D016685:Mitomycin; D007372:Interferons; D013852:Thiotepa