Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy.
We examined the insertion/deletion polymorphism in the angiotensin-converting enzyme gene and identified polymorphisms in the heart chymase gene to test the hypothesis that these angiotensin II-producing enzymes are associated with a monogenic cardiac disease (50 patients and 50 control subjects) as a model of cardiac hypertrophy. We found that the angiotensin-converting enzyme DD genotype was present more often in patients than in control subjects and identified a possible interaction with 1 of the chymase polymorphisms.
Pfeufer
A
A
Franz Volhard Clinic, Berlin, Germany.
Osterziel
K J
KJ
Urata
H
H
Borck
G
G
Schuster
H
H
Wienker
T
T
Dietz
R
R
Luft
F C
FC
D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002312:Cardiomyopathy, Hypertrophic / Q000201:enzymology / Q000235:genetics*; D053818:Chymases; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009206:Myocardium / Q000201:enzymology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D012697:Serine Endopeptidases / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases; D053818:Chymases