title: Expression of mGluR1 alpha mRNA receptor in rat and guinea pig cochlear neurons.
abstract: Glutamate or a parent substance is thought to be the afferent neurotransmitter in the auditory system. In situ hybridization showed that mGluR1 alpha mRNA was expressed by type I and type II spiral ganglion neurons in the cochlea. The glial cells surrounding the type I spiral ganglion neurons lacked such expression. The hybridization signal was low compared to that reported for non-NMDA receptors, suggesting that mGluR1 alpha receptors, as is the case for NMDA receptors, play a minor role in auditory transmission. The uniform expression of mGluR1 alpha mRNAs along the cochlear spiral suggests their co-expression in spiral ganglion neurons with NMDA and non-NMDA receptors and thus functional cooperation.
authors: NIH/NIDCD, Bethesda, MD 20892, USA.
authors: S
authors: S
authors: Safieddine
authors: M
authors: M
authors: Eybalin
mesh_terms: D000818:Animals; D003051:Cochlea / Q000737:chemistry* / Q000166:cytology; D006168:Guinea Pigs; D017403:In Situ Hybridization; D009474:Neurons / Q000737:chemistry*; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*
chemical_list: D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D018094:Receptors, Metabotropic Glutamate