Isolated vitamin E deficiency.
A 22-year-old man presented with progressive gait instability, tremor, and dysarthria since childhood. Electrophysiologic studies revealed a sensorimotor polyneuropathy. Laboratory studies documented vitamin E deficiency; however, no gastrointestinal, hepatic, or lipoprotein disorder could be identified. Vitamin E therapy normalized the serum level, but there was no neurologic improvement. Isolated vitamin E deficiency, in the absence of lipid malabsorption, should be considered in the evaluation of children and adults with ataxia and peripheral neuropathy.
Jackson
C E
CE
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7883, USA.
Amato
A A
AA
Barohn
R J
RJ
D000328:Adult; D004568:Electrodiagnosis; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D013132:Spinocerebellar Degenerations / Q000175:diagnosis / Q000209:etiology*; D014810:Vitamin E / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000150:complications* / Q000188:drug therapy
D014810:Vitamin E