title: PET-study of intracranial meningiomas: correlation with histopathology, cellularity and proliferation rate.
abstract: The glucose metabolism of 62 meningiomas was measured by fluorine -18-2-fluorodeoxyglucose (FDG) PET and correlated with proliferation rate (Ki-67 index) and tumor cellularity. The mean metabolic rate (MRGlu) for meningiomas was 0.26 +/- 0.13 mikromol/g/min (range 0.08-0.62 mikromol/g/min). The relative tumor FDG-uptake (Q-MRGlu) (tumor/contralateral cortex) of all meningiomas was calculated with 0.73 +/- 0.37 (0.24-1.79). Differences of Q-MRGlu were significant between the groups with high vs. low cellularity (p < 0.01), increased vs. normal proliferation rate (p < 0.025) and low (WHO grade I) vs. higher (WHO grades II, III) graded tumors. In recurrent meningiomas (14 tumors) the glucose metabolism was not increased. The data show that 18 FDG-PET is suitable to serve as non-invasive predictor of tumor growth characteristics in meningiomas.
authors: Department of Neurosurgery, Medical Faculty of Technical University Aachen, Federal Republic of Germany.
authors: B
authors: B
authors: Lippitz
authors: U
authors: U
authors: Cremerius
authors: L
authors: L
authors: Mayfrank
authors: H
authors: H
authors: Bertalanffy
authors: R
authors: R
authors: Raoofi
authors: J
authors: J
authors: Weis
authors: A
authors: A
authors: Böcking
authors: U
authors: U
authors: Büll
authors: J M
authors: JM
authors: Gilsbach
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019394:Ki-67 Antigen; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose