title: Thin-section CT findings of the lungs: experimentally induced bronchial and pulmonary artery obstruction in pigs.
abstract: OBJECTIVE
  The purpose of this study was to investigate whether a mosaic pattern of lung attenuation, or lobular low attenuation, is revealed on CT imaging after induction of bronchial and pulmonary artery obstruction in pigs.
  
  
  METHODS
  Eight anesthetized and ventilated pigs, four for bronchial obstruction and four for pulmonary artery obstruction, were examined with thin-section CT. Bronchial obstruction was induced at the subsegmental level using 2- to 3-mm radiopaque silicon spheres at 14 sites. Pulmonary artery obstruction was induced at 11 sites by dislodging 2- to 3-mm silicon spheres at the level of the superior vena cava. CT scans were obtained at end expiration immediately after the obstruction in all pigs (n = 8) and after 1 day (n = 3), 3 days (n = 5), 7 days (n = 4), 14 days (n = 4), and 28 days (n = 3).
  
  
  RESULTS
  Of the 14 sites of bronchial obstruction, six sites (43%) on the immediate scans showed a lobular distribution of low attenuation distal to the spheres, which changed to atelectasis, consolidation, or normal on follow-up CT. Of the four sites that did not show changes in lung attenuation on immediate CT scans, two sites showed lobular low attenuation after 1 day. The mean attenuation value +/- SD for the lobular low attenuation was -737 H +/- 122 and that of the adjacent lung was -522 H +/- 53 (p = .0077). None of the pulmonary artery obstruction sites showed visible change in lung attenuation, and mean attenuation values for obstructed sites and unobstructed sites did not show significant differences when scanned as many as 28 days after the immediate scans.
  
  
  CONCLUSIONS
  Lobular low attenuation on thin-section CT was induced by bronchial obstruction, but we found no change in lung attenuation due to obstruction of the pulmonary arteries as many as 28 days after the immediate scans.
authors: Department of Radiology, Seoul National University College of Medicine, Korea.
authors: J G
authors: JG
authors: Im
authors: Y W
authors: YW
authors: Choi
authors: H D
authors: HD
authors: Kim
authors: Y K
authors: YK
authors: Jeong
authors: M C
authors: MC
authors: Han
mesh_terms: D000818:Animals; D001982:Bronchial Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D003250:Constriction; D008168:Lung / Q000000981:diagnostic imaging*; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000209:etiology; D013552:Swine; D013997:Time Factors; D014057:Tomography, X-Ray Computed