Hyperlipidemia associated with multiple myeloma.
A 70-year-old woman with type IIb therapy-refractory hyperlipidemia was diagnosed as having IgA kappa type multiple myeloma. She had neither a family history nor any other disease known to accompany hyperlipidemia. The serum IgA concentration fell from 3.42 g/dl to 1.24 g/dl following chemotherapy with melphalan and prednisolone, and a concomitant decrease in both the serum cholesterol and triglyceride levels was observed. These serum lipids were positively correlated with the serum IgA concentration (p < 0.001) during the three cycles of chemotherapy. These findings suggest the involvement of the monoclonal protein of IgA in the development of hyperlipidemia in the present case.
Fukudome
K
K
First Department of Internal Medicine, Miyazaki Medical College.
Kato
J
J
Ohashi
T
T
Yamamoto
Y
Y
Eto
T
T
D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000209:etiology; D007070:Immunoglobulin A / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D008558:Melphalan / Q000008:administration & dosage; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D014280:Triglycerides / Q000097:blood
D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D014280:Triglycerides; D002784:Cholesterol; D011239:Prednisolone; D008558:Melphalan