title: Effect of benzisoselenazolones and organic diselenides on graft versus host reaction and immunoglobulins levels in chickens.
abstract: Two week old chickens were treated once daily for 5 days with AE8--1-pyridyl-1,2-benzisoselenazol-3(2H)-one, AE22--bis-2-(N-phenyle-carboxamido) 1 pyridyl diselenide and AE31--bis(phenylo-diselenide with R3 = CONHC18H37). Their whole blood alone or blood mixed with thymus cells were used to generate graft versus host (GvH) reaction in 15 day old chicken embryos. The treatment of the chickens with the compounds stimulated the GvH reaction modifying activity of the donor cells as measured by increase of the spleen weight of the recipient chicken embryos. On the other hand, treatment with these compounds inhibited the IgG or IgM production in chickens immunized with human albumin.
authors: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
authors: B
authors: B
authors: Błaszczyk
authors: A D
authors: AD
authors: Inglot
authors: P
authors: P
authors: Toivanen
authors: J
authors: J
authors: Młochowski
authors: S
authors: S
authors: Szymaniec
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D016566:Organoselenium Compounds / Q000494:pharmacology*; D012756:Sheep
chemical_list: D007136:Immunoglobulins; D016566:Organoselenium Compounds