[Clinical and immunological study of airway disease in collagen vascular disease].
We studied the clinical and immunological characteristics of patients with bronchiolar diseases associated with collagen vascular disease (15 patients with rheumatoid arthritis and 1 primary Sjögren's syndrome). Histological examinations showed that 9 patients had follicular bronchiolitis and 7 had bronchiolitis obliterans. Follicular bronchiolitis was characterized by hyperplasia of bronchus-associated lymphoid tissue, and immunohistochemical studies revealed that the pattern of distribution of T cells and B cells in bronchus-associated lymphoid tissue from patients with follicular bronchiolitis was similar to that in diffuse panbronchiolitis, which may be used as a representative model of chronic respiratory infection. In addition, bacterial cultures of sputum samples were positive in 44% of patients with follicular bronchiolitis and in 71% of patients with bronchiolitis obliterans. These results suggest that antigen stimulation is involved in the development of bronchiolar diseases associated with collagen vascular disease.
Hayakawa
H
H
Second Divsison, Internal Medicine, Hamamatsu University School of Medicine.
Sato
A
A
Imokawa
S
S
Iwata
M
M
Chida
K
K
D000368:Aged; D015703:Antigens, CD; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology*; D001402:B-Lymphocytes; D001980:Bronchi / Q000166:cytology / Q000276:immunology; D001988:Bronchiolitis / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D018655:Lymphocyte Count; D008297:Male; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology*; D013601:T-Lymphocytes
D015703:Antigens, CD; D007136:Immunoglobulins