[Antithrombin III and alpha 2-antiplasmin in blood of patients operated on for benign prostatic hyperplasia].
The pre- and postoperative activity was studied of antithrombin III (AT III) and alpha 2-antiplasmin (alpha 2-AP) in blood of 40 patients subjected to transurethral prostatic electroresection due to benign prostatic hyperplasia (BPH). For comparison of the obtained results a control group was formed from patients with other diseases of the genitourinary system with exception of neoplasms. The activity of AT III and alpha 2-AP before the operation was similar to that in the control group. Intraoperatively (day 0) and on the first day after the operation, a statistically significantly lower activity of AT III and alpha 2-AP was found in the patients with BPH in relation to the initial value as well as to the control group. On day 5 after the operation, normalization of AT III and alpha 2-AP activity was found. During operations of the prostate a release occurs of thromboplastins and plasminogen activators initiating the activation of blood clotting and fibrinolysis. The decrease of activity of AT III and alpha 2-AP could be caused by AT III and alpha 2-AP use-up in the process of inhibition of the created thrombin and plasmin.
Zietek
Z
Z
Katedry i Kliniki Urologii, Katedry i Zakładu Patofizjologii AM w Bydgoszczy.
Iwan-Zietek
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I
Kotschy
M
M
Tyloch
F
F
D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000601:surgery; D015842:Serine Proteinase Inhibitors / Q000378:metabolism*; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D015842:Serine Proteinase Inhibitors; D000979:alpha-2-Antiplasmin; D000990:Antithrombin III; D005341:Fibrinolysin
Aktywność antytrombiny III i alpha 2-antyplazminy we krwi chorych operowanych z powodu łagodnego rozrostu gruczołu krokowego.