Effects of loratadine on postural control.
The effects of classical sedating antihistamines on cognitive and perceptual functions are well known. Loratadine is a new antihistamine without sedative effects. In this study, loratadine 10 and 40 mg daily, clemastine 2 mg twice daily and placebo were evaluated in 8 healthy subjects in terms of effects on equilibrium as measured with dynamic posturography. Dynamic posturography comprises a sensory organization part in which the support surface and visual surround are either stable or referenced to the patient's sway, with eyes open or closed. In a movement coordination part, the platform makes active movements. Analysis of variance showed no effects on equilibrium attributable to loratadine. Comparing substances pairwise, however, a significant difference between loratadine and clemastine was displayed in 2 out of 6 sensory test conditions. In conclusion, loratadine can be considered safe regarding balance functions.
Ledin
T
T
Department of ENT, University Hospital, Linköping, Sweden.
Odkvist
L M
LM
Möller
C
C
D000328:Adult; D002974:Clemastine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D017336:Loratadine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D004856:Postural Balance / Q000187:drug effects*; D011187:Posture; D011930:Reaction Time / Q000187:drug effects; D014724:Vestibular Function Tests
D006634:Histamine H1 Antagonists; D017336:Loratadine; D002974:Clemastine