2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506).
New clinically useful drug, 2-chlorodeoxyadenosine (2-CdA), was found to be a potent immunosuppressant both in vitro and in vivo. The present study examines the in vitro interactions of classical immunosuppressive agents--FK 506 and Cyclosporine A (CsA) with 2-CdA at the level of T and B cells proliferation, expression receptor for interleukin 2 (R-IL-2) and Ig synthesis. No synergism between 2-CdA and either FK 506 or CsA was demonstrable.
Nowaczyk
M
M
Department of Immunology, Transplantation Institute, Medical Academy, Warsaw, Poland.
Stephień-Sopniewska
B
B
Korczak-Kowalska
G
G
Mrowiec
T
T
Górski
A
A
D001402:B-Lymphocytes / Q000187:drug effects; D002478:Cells, Cultured; D017338:Cladribine / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016559:Tacrolimus / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D017338:Cladribine; D016572:Cyclosporine; D016559:Tacrolimus