Myosin-V: a class of unconventional molecular motors.
In this review we focus on the biochemical and structural properties of the myosin-V class of unconventional myosins as an example of the diversity of molecular motors within the myosin superfamily. A member of this class was first identified as a novel calmodulin-binding protein in mammalian brain (Larson RE, Pitta DE and Ferro JA (1988). Brazilian Journal of Medical and Biological Research, 21: 213-217). To date, the myosin-V class is represented by two molecules from yeast, one from nematodes, several from vertebrates (chickens, rats, mice and humans) and possibly one from plants. The domain structure of these myosins features a highly conserved head containing the ATP-hydrolysis and actin-binding sites, an extended neck composed of six tandem IQ-motifs which are sites for calmodulin binding and a large tail which has coiled-coil segments intercalated with globular regions of as yet unknown function. Biochemical studies on purified myosin-V from vertebrate brains and the description of myosin-V mutants in yeast and mice have made myosin-V one of the best characterized, unconventional myosin classes at the present time, surpassed only by the well-studied myosin-I class.
Larson
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RE
Departamento de Bioquímica, Universidade de São Paulo, Brasil.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D000656:Amoeba; D000818:Animals; D001665:Binding Sites; D001717:Birds; D002148:Calmodulin-Binding Proteins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D004330:Drosophila; D006801:Humans; D008322:Mammals; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D024701:Myosin Type V; D009348:Nematoda; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D010944:Plants; D051381:Rats; D017422:Sequence Analysis, DNA; D015003:Yeasts
D002148:Calmodulin-Binding Proteins; D009419:Nerve Tissue Proteins; C078829:chicken brain myosin-V p190; D000255:Adenosine Triphosphate; D024701:Myosin Type V