Effects of adrenodemedullation and adrenalectomy on the 5-HT2 receptor agonists DOI-and mCPP-induced hypophagia in rats.
Effects of adrenodemedullation and adrenalectomy on the serotonin2 (5-HT2) receptor agonists-induced hypophagia were investigated. Hypophagia induced by both the 5-HT2A/2C, receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the 5-HT2C-receptor agonist 1-(3-chlorophenyl)piperazine (mCPP) were not affected by adrenodemedullation. In adrenalectomized rats. DOI did not induce hypophagia, while mCPP elicited apparent effects. These results suggest that neither DOI- nor mCPP-induced hypophagia was not associated with adrenaline release from the adrenal medulla. Moreover, our results suggest that DOI-induced hypophagia is involved in corticosterone-sensitive feeding, although other mechanisms which are not related to corticosterone are involved in mCPP-induced anorexia.
Yamada
J
J
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Sugimoto
Y
Y
Yoshikawa
T
T
Horisaka
K
K
D000313:Adrenal Medulla / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D004435:Eating / Q000187:drug effects*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
D010879:Piperazines; D017366:Serotonin Receptor Agonists; C015068:1-(3-chlorophenyl)piperazine