[Expression of Fas/Fas ligand and proto-oncogenes in rheumatoid synovial tissues].
Expression of Fas antigen and Fas ligand (-L) were observed in synovial tissue from rheumatoid arthritis (RA) patients, whereas in only a few cells expressed these molecule osteoarthritis synovial tissue. Fas-L was expressed on CD45RO, CD4, CD8 or CD56 positive cells in RA synovial tissue. Moreover, 10 to 30% of synovial cells expressing Fas antigen were observed to be identical with apoptotic synovial cells and Fas expression was closely related to c-fos and c-myc. These findings suggest that activated T cells and natural killer cells infiltrating into the RA synovium may play an important role in the induction of apoptosis of RA synovial cells through Fas/Fas-L interactions.
Asahara
H
H
Division of Rheumatology and Immunology, St. Marianna University School of Medicine.
Hasunuma
T
T
Obata
T
T
Sumida
T
T
Nishioka
K
K
D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D011519:Proto-Oncogenes; D013583:Synovial Membrane / Q000166:cytology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic; D019014:fas Receptor / Q000378:metabolism / Q000502:physiology
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor