Targeting toxins to neural antigens and receptors.
Immunotoxins have been used to study the targeting of biologically active substances at neurons in vivo and to make experimental neural lesions. OX7-saporin, directed against Thy 1, destroys any neuron. 192 IgG-saporin, directed against the 'low affinity' neurotrophin receptor (p 75NTR), selectively destroys neurons expressing this receptor (sympathetic, sensory, cholinergic basal forebrain, cerebellar Purkinje). Anti-D beta H-saporin, directed against dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine, selectively destroys noradrenergic neurons (sympathetic, CNS). These agents show that several types of neural antigens may prove useful in treating pain, and anti-D beta H-saporin may be active against pheochromocytoma or neuroblastoma.
Wiley
R G
RG
Neurology Service, Vanderbilt University, Nashville, TN, USA.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D018678:Cholinergic Agents / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000276:immunology; D005544:Forecasting; D006026:Glycoside Hydrolases / Q000494:pharmacology; D006801:Humans; D018796:Immunoconjugates; D000922:Immunotoxins / Q000494:pharmacology*; D051379:Mice; D009699:N-Glycosyl Hydrolases; D009474:Neurons / Q000187:drug effects*; D010940:Plant Proteins / Q000494:pharmacology; D051381:Rats; D015375:Receptors, Interleukin-2 / Q000235:genetics / Q000276:immunology; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins; D013601:T-Lymphocytes; D014667:Vasopressins / Q000276:immunology
C085696:192 IgG-saporin; D000911:Antibodies, Monoclonal; D018678:Cholinergic Agents; D018796:Immunoconjugates; D000922:Immunotoxins; C085346:OX7-saporin; D010940:Plant Proteins; D015375:Receptors, Interleukin-2; D054789:Ribosome Inactivating Proteins, Type 1; C101397:anti-dopamine beta-hydroxylase immunotoxin; D014667:Vasopressins; D004299:Dopamine beta-Hydroxylase; D006026:Glycoside Hydrolases; D009699:N-Glycosyl Hydrolases; D000076985:Saporins