Technetium-99m-HMPAO labelled leucocytes in the detection and monitoring of inflammatory bowel disease in children.
This study was a retrospective evaluation of the use of technetium-99m hexamethylpropyleneamineoxime (HMPAO) labelled leucocytes in the investigation of suspected inflammatory bowel disease in children. The images were analysed in 35 children and the findings were compared with the results of endoscopy/biopsy, barium studies and antinuclear cytoplasm antibody (ANCA) serology. The sensitivity of the white cell scan was 83% and the specificity 81%. This compares well with other studies in adults and is superior to barium investigations. The technique is recommended as a first line investigation to detect inflammatory bowel disease with a resultant reduction in the use of endoscopy and barium imaging.
Jewell
F M
FM
Department of Clinical Radiology, Bristol Children's Hospital, UK.
Davies
A
A
Sandhu
B
B
Duncan
A
A
Grier
D
D
D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood; D001466:Barium Sulfate; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003424:Crohn Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015609:Organotechnetium Compounds; D010091:Oximes; D001466:Barium Sulfate; D019690:Technetium Tc 99m Exametazime