title: Magnetic resonance perfusion imaging with gadolinium-DTPA. A quantitative approach for the kinetic analysis of first-pass residue curves.
abstract: OBJECTIVE
  To present a mathematic approach for the analysis of first-pass gadolinium (Gd)-DTPA kinetics and to validate the numerical tools using simulated and measured kinetics.
  
  
  METHODS
  In a capillary plasma filter, pulsatile flow was varied between 7.4 and 12.6 mL/second. After contrast bolus injection, the arterial input curve and the residue curve were recorded simultaneously. Signal intensity versus time curves were converted to concentration versus time curves. By deconvolution of these curves and tracer kinetic analysis, the mean transit time of the contrast medium through the organ model was calculated.
  
  
  RESULTS
  A satisfactory correlation (r = 0.98) between the inverse of mean transit time and flow measured volumetrically was demonstrated.
  
  
  CONCLUSIONS
  The kinetic analysis of first-pass curves in an organ model indicates that this approach might be useful for in vivo assessment of organ blood flow.
authors: Strahlenklinik, Virchow-Klinikum Medizinische Fakultät der Humboldt Universitat zu Berlin, Germany.
authors: J C
authors: JC
authors: Böck
authors: O
authors: O
authors: Henrikson
authors: A H
authors: AH
authors: Götze
authors: W
authors: W
authors: Wlodarczyk
authors: B
authors: B
authors: Sander
authors: R
authors: R
authors: Felix
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007700:Kinetics; D018810:Magnetic Resonance Angiography; D019028:Magnetic Resonance Imaging, Cine; D008955:Models, Cardiovascular; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA