Addison's disease presenting with cerebral edema.
BACKGROUND
Increased intracranial pressure with encephalopathy has rarely been reported in Addison's disease.


METHODS
Case Study.


RESULTS
A 16-year-old female who presented with cerebral edema of unknown etiology was eventually diagnosed as having Addison's disease. She had early morning headaches, fatiguability, diarrhea and deterioration in school performance. She was hyponatremic with a serum sodium of 128 mmol/L and hyperkalemic with a serum potassium of 5.9 mmol/L. She had a low serum osmolality (264 mosm), high urine osmolality (533 mosm) and high urine sodium (87 mosm). She had a postural drop in blood pressure and diffuse hyperpigmentation. An ACTH stimulation test revealed a low baseline cortisol and no response to ACTH. Plasma renin activity was increased. Serum ACTH was elevated. She responded well to intravenous fluids and solu-cortef and was discharged on hydrocortisone and florinef. She remains well 18 months after the acute episode with no neurologic complaints or findings.


CONCLUSIONS
Addison's Disease should be considered in the differential diagnosis of symptomatic cerebral edema and idiopathic intracranial hypertension.
Geenen
C
C
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada.
Tein
I
I
Ehrlich
R M
RM
D000224:Addison Disease / Q000473:pathology*; D000293:Adolescent; D001929:Brain Edema / Q000473:pathology*; D005260:Female; D006801:Humans; D011379:Prognosis; D014057:Tomography, X-Ray Computed