title: Trials of the effects of drugs and hormones on lipids and lipoproteins.
abstract: Recent trials on the efficacy of drugs and hormones in lowering cholesterol and correcting lipoprotein profiles are reviewed. Emphasis is placed on the risk-benefit ratio, which determines the clinical value of therapeutic regimens. Whereas 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors have set a standard for treatment of hyperlipidaemia, the role of hormone replacement therapy in postmenopausal women in the prevention of coronary artery disease has more recently become better defined.
authors: Medizinische Kernklinik und Poliklinik, Universitäts-Krankenhaus Eppendorf, Hamburg, Germany.
authors: W A
authors: WA
authors: Mann
authors: E
authors: E
authors: Windler
authors: F U
authors: FU
authors: Beil
authors: H
authors: H
authors: Greten
mesh_terms: D002986:Clinical Trials as Topic; D015914:Estrogen Replacement Therapy; D005260:Female; D006728:Hormones / Q000494:pharmacology / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D009525:Niacin / Q000627:therapeutic use; D011341:Probucol / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000627:therapeutic use
chemical_list: D006728:Hormones; D000960:Hypolipidemic Agents; D008055:Lipids; D008074:Lipoproteins; D013963:Thyroid Hormones; D019382:Human Growth Hormone; D009525:Niacin; D011341:Probucol