Portal hypertensive colopathy in patients with cirrhosis.
BACKGROUND
Colonic vascular ectasias and colorectal varices have been observed in patients with cirrhosis. However, the pathogenesis of these vascular lesions has not been established.


METHODS
We enrolled 35 cirrhotic patients and 20 normal controls in this study. All received colonoscopic examinations and measurements of plasma glucagon levels. Portal pressure measurements were performed in all the cirrhotic patients.


RESULTS
Colonic vascular ectasias occurred more commonly in cirrhotic patients than in controls (17 of 35 versus 0 of 20; p = 0.009) and more commonly in cirrhotic patients with ascites than in those without (15 of 24 versus 2 of 11; p = 0.038). However, the presence of colonic vascular ectasias was not related to the hepatic venous pressure gradient or plasma glucagon levels. Colorectal varices also occurred more commonly in cirrhotic patients than in controls (16 of 35 versus of 1 of 20; p = 0.034), but the hepatic venous pressure gradient, plasma glucagon levels, and severity of cirrhosis were not related to the presence of colorectal varices.


CONCLUSIONS
Portal hypertension per se and increased plasma glucagon levels may not play an important role in the pathogenesis of colonic vascular ectasias or colorectal varices in patients with cirrhosis.
Chen
L S
LS
Dept. of Medicine, Veterans General Hospital, Taipei, Taiwan.
Lin
H C
HC
Lee
F Y
FY
Hou
M C
MC
Lee
S D
SD
D000368:Aged; D016022:Case-Control Studies; D003106:Colon / Q000098:blood supply*; D003113:Colonoscopy; D005934:Glucagon / Q000097:blood; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology*; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D017082:Portal Pressure; D012007:Rectum / Q000098:blood supply*; D014648:Varicose Veins / Q000209:etiology*
D005934:Glucagon