[Apoptosis in the process from viral myocarditis to dilated cardiomyopathy].
Detection of viral genomic RNAs in myocardium of dilated cardiomyopathy (DCM) suggested the relationship between DCM and viral myocarditis. The viral infection may cause cytokine expression followed by induction of inducible nitric oxide synthase (iNOS) and expression of Fas antigen. The iNOS has potent and long-lasting effects on NO generation, has cytotoxic effects and triggers apoptosis in car diomyocytes. In addition, the expression of Fas antigen directly induces apoptosis.
Satoh
M
M
Second Department of Internal Medicine, Iwate Medical University School of Medicine.
Hiramori
K
K
Tamura
G
G
Satodate
R
R
D017209:Apoptosis; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D009205:Myocarditis / Q000150:complications / Q000821:virology*; D009206:Myocardium / Q000166:cytology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D012367:RNA, Viral; D019014:fas Receptor / Q000378:metabolism
D016207:Cytokines; D012367:RNA, Viral; D019014:fas Receptor; D019001:Nitric Oxide Synthase