On the functional significance of primate retinal dopamine receptors.
Diverse dopamine receptors have been identified in the primate retina. Evidence summarized from human and monkey retinal electrophysiological studies (ERG) suggests that separate D1 and D2 receptor activation results in stimulus dependent antagonistic effects. Studies were performed using Haloperidol, 1-sulpiride, CY 208-243 and dopamine. It is inferred that the antagonistic functions of D1 and D2 receptors synergistically determine the inverted U-shaped spatial contrast response function of the primate retina. An understanding of the logic performed by retinal D1 and D2 receptors may be useful to discern properties of the role of diverse dopamine receptors in basal ganglia DA circuits.
Bodis-Wollner
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Department of Neurology, State University of New York--Health Science Center at Brooklyn, USA.
Antal
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D000818:Animals; D004298:Dopamine / Q000502:physiology; D065127:Dopamine D2 Receptor Antagonists; D004596:Electroretinography; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D014795:Visual Pathways / Q000187:drug effects
D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D004298:Dopamine