title: Giant splenic cyst with high serum concentration of CA 19-9. Failure of treatment with percutaneous transcatheter drainage and injection of tetracycline.
abstract: BACKGROUND
  Recently, several cases of nonparasitic true splenic cyst with high serum concentration of carbohydrate antigen (CA 19-9) have been reported.
  
  
  METHODS
  We report a giant splenic cyst presenting with high serum concentration of CA 19-9 in a 21-year-old man without a history of previous trauma. Imaging techniques showed a huge monolocular cyst of the spleen, and laboratory data showed increased serum CA 19-9 levels (326 U/ml; normal, < 37 U/ml). Serologic test was negative for parasitic infection. These findings led us to the diagnosis of epithelial splenic cyst. Percutaneous transcatheter drainage and injection of tetracycline were performed for 2 weeks. The cyst shrank, and the serum CA 19-9 level decreased favorably. However, cystic fluid reaccumulated in a month.
  
  
  CONCLUSIONS
  The accumulation of cystic fluid in splenic epithelial cysts may be attributable not only to the secretion of the lining cells but also to influx from the splenic sinuses.
authors: Dept. of Internal Medicine, Kariya General Hospital, Japan.
authors: H
authors: H
authors: Yoshikane
authors: T
authors: T
authors: Suzuki
authors: N
authors: N
authors: Yoshioka
authors: Y
authors: Y
authors: Ogawa
authors: Y
authors: Y
authors: Hayashi
authors: E
authors: E
authors: Hamajima
authors: T
authors: T
authors: Yokoi
mesh_terms: D000328:Adult; D018395:CA-19-9 Antigen / Q000097:blood*; D003131:Combined Modality Therapy; D003560:Cysts / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D004322:Drainage / Q000379:methods; D006801:Humans; D008297:Male; D012008:Recurrence; D012597:Sclerosing Solutions / Q000627:therapeutic use; D015911:Sclerotherapy; D013158:Splenic Diseases / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D013752:Tetracycline / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D018395:CA-19-9 Antigen; D012597:Sclerosing Solutions; D013752:Tetracycline