[The olfactory neurotoxicity of cisplatin and effects of two drugs].
32 guinea pigs were used as animal models for the study of cisplatin induced olfactory neurotoxicity and the effects of sodium thiosulfate (STS) and cystine on the toxicity by light and electron microscopy. The results revealed that the olfactory epithelium, olfactory nerve and the olfactory bulb were all damaged by the application of cisplatin and manifested as the lysis of the myelinated nerve fibers of olfactory epithelium, edema and degeneration of the axons, atrophy of the olfactory epithelium and the compensatory proliferation of Bowman's glands. STS and cystine did not show significant effects on the neurotoxicity of cisplatin. The data suggested that cisplatin is an important toxic drug for olfactory system.
Zhou
G
G
First Hospital of Guiyang Medical College.
Lin
S
S
D000818:Animals; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D003553:Cystine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects / Q000648:ultrastructure; D009831:Olfactory Mucosa / Q000187:drug effects / Q000648:ultrastructure; D009832:Olfactory Nerve / Q000187:drug effects* / Q000648:ultrastructure; D013885:Thiosulfates / Q000494:pharmacology*
D013885:Thiosulfates; D003553:Cystine; D002945:Cisplatin