Prevalence of impaired responsiveness to epinephrine in platelets among Japanese.
The responsiveness of platelets only to epinephrine was markedly impaired in 23/140 (16%) healthy Japanese. The impaired responsiveness was not altered by changes in time and environment. Circulating level of catecholamines did not affect the responsiveness of platelets to epinephrine. A pilot family study indicated a possible familial nature of the defect. 3H methyl-yohimbine binding studies indicated that this defect was due to the decreased number of alpha 2 adrenergic receptor. Despite the defect, the potentiating effect of epinephrine on platelet aggregation stimulated by a low dose of ADP was normal. This abnormality is not apparently associated with any bleeding disorders and the clinical implication is unknown at present. It is, however, essential to acknowledge the prevalence of such defect in pursuing research on platelets stimulated by epinephrine.
Kambayashi
J
J
Department of Surgery II, Osaka University Medical School, Japan.
Shinoki
N
N
Nakamura
T
T
Ariyoshi
H
H
Kawasaki
T
T
Sakon
M
M
Monden
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002395:Catecholamines / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010865:Pilot Projects; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D015995:Prevalence; D018341:Receptors, Adrenergic, alpha-2 / Q000172:deficiency* / Q000187:drug effects / Q000235:genetics; D015016:Yohimbine / Q000031:analogs & derivatives / Q000378:metabolism
D002395:Catecholamines; D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine; C046153:1-methylyohimbine; D000244:Adenosine Diphosphate; D004837:Epinephrine