[Neuromuscular action of crotalid venoms: preliminary data].
We studied 6 patients and 2 dogs that have been bitten by South American rattlesnake Crotalus durissus terrificus and one rabbit inoculated with crotalid venom. We analyzed sensory and motor peripheral nerve conduction, repetitive stimulation for studying neuromuscular transmission and electromyographies. Muscle biopsies were processed by histochemistry. All patients had peripheral mononeuropathy of the closest sensitive nerve to the area of snakebite. The neuromuscular transmission alterations were minimal. Muscle histochemistry of 4 patients, 2 dogs and 1 rabbit showed findings of mitochondrial myopathy. The majority of authors admit that crotalid venom causes myastenic syndrome. Our findings suggest that palpebral ptosis, myastenic facies and muscular weakness observed after crotalid poisoning are, probably, due to transient and reversible mitochondrial myopathy. As far as we know, this is the first report on the ability of the venom of this rattlesnake to cause local sensitive mononeuropathy and the first muscle histochemistry showing mitochondrial myopathy in humans poisoned by crotalid venom.
Dorvalina Silva
M
M
Departamentos de Neurologia, Moléstias Infecciosas e Patologia da Faculdade de Medicina de Botucatu, UNESP, Brasil.
Resende
L A
LA
Kimuni Ueda
A
A
Barraviera
B
B
Mendes
R P
RP
Montenegro
M R
MR
D000818:Animals; D001938:Brazil; D003435:Crotalid Venoms / Q000506:poisoning*; D004285:Dogs; D004576:Electromyography; D006801:Humans; D008297:Male; D017240:Mitochondrial Myopathies / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D009469:Neuromuscular Junction / Q000473:pathology / Q000503:physiopathology; D011817:Rabbits
D003435:Crotalid Venoms
Ação neuro-muscular do veneno crotálico: dados preliminares.