Antiplatelet flavonoids from seeds of Psoralea corylifolia.
The MeOH extract of the seeds of Psoralea corylifolia L. was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid, collagen, and platelet activating factor. Bioassay-directed fractionation led to the isolation of three flavonoids, isobavachalcone (1), neobavaiso-flavone (2), and bavachin (3). Compounds 1 and 2 inhibited platelet aggregation.
Tsai
W J
WJ
National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
Hsin
W C
WC
Chen
C C
CC
D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013624:Taiwan
D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors