Reduced ageing effects of striatal neuronal discharge rate by aged ventral mesencephalic grafts.
Long-term survival of fetal ventral mesencephalic grafts implanted into dopamine-depleted rats was studied. There was a reduction in apomorphine-induced rotations, which reached a maximum 3 months post-grafting. Striatal neuronal discharge rate was increased on the intact side of the aged grafted animals when compared with young adult striatum. Ipsilateral to the lesion, proximal to the graft, where the dopamine nerve terminal density was high but still much lower than that seen on the intact side, the firing rate was significantly lower than that measured in the intact side of the aged host. In conclusion, the increased firing rate seen in striatum after dopamine depletion is normalized by ventral mesencephalic grafts and does not show the age-related increase seen in 2-year-old rats.
Strömberg
I
I
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Bickford
P
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D016380:Brain Tissue Transplantation / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D007150:Immunohistochemistry; D008636:Mesencephalon / Q000637:transplantation*; D017072:Neostriatum / Q000166:cytology / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D013239:Stereotyped Behavior / Q000187:drug effects; D013563:Sympathectomy, Chemical; D013565:Sympatholytics; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D018491:Dopamine Agonists; D013565:Sympatholytics; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine