Prolonged islet allograft acceptance in the absence of interleukin 4 expression.
Murine CTLA4/Fc therapy leads to permanent engraftment of islet allografts in interleukin 4 (IL-4) knockout (IL-4-/- mice. Interestingly, IL-4+/- hosts were more resistant to tolerance induction than IL-4-/- mice. An IL-2/Fc fusion protein abrogates the effect of CTLA4/Fc therapy while an IL-4/Fc fusion protein tends to inhibit rather than enhance the effect of CTLA/Fc treatment in IL-4-/- recipients. We conclude that allograft acceptance requires principally a blockade of T cell activation rather than 'immune deviation' of the T cell activation program to Th2 cytokines (i.e. IL-4).
Nickerson
P
P
Harvard Medical School, Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215, USA.
Zheng
X X
XX
Steiger
J
J
Steele
A W
AW
Steurer
W
W
Roy-Chaudhury
P
P
Müller
W
W
Strom
T B
TB
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D015847:Interleukin-4 / Q000502:physiology*; D016381:Islets of Langerhans Transplantation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D051381:Rats; D014162:Transfection
D015847:Interleukin-4