Role of lipoproteins in platelet activation.
Native low density lipoprotein influences platelets principally in a time- and dose-dependent manner. Oxidized low density lipoprotein activates platelets and promotes platelet adhesion. Certain parts of high density lipoprotein may decrease the risk of platelet activation. The calcium signaling pathway, protein kinase C pathway, and cytotoxic effect are probably involved in the platelet activation process.
Zhao
B
B
Platelet Research Unit, Medical Faculty, University of Münster, Germany. ZHAO@Uni-Muenster.de
D002118:Calcium / Q000097:blood; D003600:Cytosol / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D008074:Lipoproteins / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D010084:Oxidation-Reduction; D015539:Platelet Activation; D010973:Platelet Adhesiveness
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002118:Calcium