Genetic polymorphism of the 3' VNTR region of the human dopaminergic function gene DAT1 (human dopamine transporter gene) in the Mongolian population.
The hypervariable region of the dopamine transporter gene (DAT1) was amplified from samples in the Mongolian population. This region includes a variable number of tandem repeats of a 40-bp core unit in the 3' untranslated region of DAT1. Vandenbergh et al. (1992) reported variability in the number of repeats of this 3' flanking region ranging from 3 to 11 times in white and black populations. We examined polymorphism at the DAT1 locus in 78 native Mongolian subjects. We found alleles with 7 to 13 repeats, which is different from the findings of Vandenbergh et al. (1992). The allele distribution of the Mongolian population is similar to that in the Japanese population, reported previously by Nakatome et al. (1995). Chi-square analysis showed a significant lack of homogeneity between our findings in Mongolian subjects and those reported previously in white and black populations. The DAT1 locus was estimated to have a heterozygosity index of 14.1%, and the polymorphic information content was calculated to be 0.16.
Nakatome
M
M
Department of Legal Medicine, Osaka University Medical School, Japan.
Honda
K
K
Tun
Z
Z
Kato
Y
Y
Harihara
S
S
Omoto
K
K
Misawa
S
S
Gerelsaikhan
T
T
Nyamkhishig
S
S
Dashnyam
B
B
Batsuuri
J
J
Wakasugi
C
C
D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D016009:Chi-Square Distribution; D050483:Dopamine Plasma Membrane Transport Proteins; D005787:Gene Frequency; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D018598:Minisatellite Repeats / Q000235:genetics*; D008969:Molecular Sequence Data; D008986:Mongolia; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human