Effect of M-711 on experimental skin reactions induced by chemical mediators in rats.
We investigated the mechanism of anti-allergic action of Moku-boi-to (M-711) and effects on the skin reactions induced by chemical mediators as the model of allergic dermatitis. More than 20 mg/kg BW of M-711 significantly suppressed the enhancement of capillary permeability induced by histamine, LTC4, and anti-serum in the rat skin. Anti-histaminic effect of 40 mg/kg BW of M-711 was equipotent to same as the optimal doses of azelastine and diphenhydramine, respectively. As to anti-LTC4 action, 20 mg of M-711 was compared to the optimal dose of diphenhydramine. Those data showed that M-711 has the suppressive effects on the chemical mediators such as histamine and LTC4 and reduced the skin reaction induced by antigen-antibody response.
Shichinohe
K
K
Department of Laboratory Animal Science, Nippon Medical School, Tokyo, Japan.
Shimizu
M
M
Kurokawa
K
K
D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy*; D003907:Dexamethasone / Q000627:therapeutic use; D004155:Diphenhydramine / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D017997:Leukotriene C4 / Q000633:toxicity*; D008297:Male; D010793:Phthalazines / Q000627:therapeutic use; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012882:Skin Tests
D018926:Anti-Allergic Agents; D004365:Drugs, Chinese Herbal; D010793:Phthalazines; C099755:moku-boi-to; D017997:Leukotriene C4; D003907:Dexamethasone; D004155:Diphenhydramine; C020976:azelastine