[Acute and reversible myoclonic encephalopathy, extrapyramidal syndrome, polyneuropathy caused by chronic disulfiram poisoning].
This 44-year woman was admitted for weight loss and global intellectual slowing. She had mild chronic alcoholic neuropathy. She was discontinued alcoholic consumption for 6 months and was given disulfiram (1.5 g/day) since then. She developed over a 5-day period acute neuropathy, confusion and extrapyramidal symptoms with oculo-cephalogyric and dystonic movements and myoclonus. Electromyography revealed a severe polyneuropathy. After disulfiram withdrawal, confusion and extrapyramidal symptoms disappeared within a few days, but sensitivo-motor deficit improved more slowly. Nerve biopsy was suggestive of a pure axonal neuropathy.
De Sèze
J
J
Service de Neurologie, CHU Lille.
Caparros-Lefebvre
D
D
Nkenjuo
J B
JB
Hurtevent
J F
JF
Petit
H
H
D000208:Acute Disease; D000328:Adult; D000427:Alcohol Deterrents / Q000506:poisoning*; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D002908:Chronic Disease; D004221:Disulfiram / Q000506:poisoning*; D005260:Female; D006801:Humans; D009207:Myoclonus / Q000139:chemically induced*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D013997:Time Factors
D000427:Alcohol Deterrents; D004221:Disulfiram
Encéphalopathie myoclonique, syndrome extrapyramidal, polyneuropathie aigus et réversibles par intoxication chronique au disulfiram.