title: Xenopus Xsal-1, a vertebrate homolog of the region specific homeotic gene spalt of Drosophila.
abstract: We have isolated an amphibian homolog of the homeotic gene spalt of Drosophila. Like its Drosophila counterpart the Xenopus Xsal-1 gene encodes a protein that contains three widely separated sets of sequence related double zinc finger motifs of the CC/HH-type as well as a single CC/HH zinc finger. The Xenopus gene encodes a fourth double zinc finger and a single CC/HC zinc finger motif that have no counterpart in the fly protein. Alternative splicing of Xsal-1 transcripts gives rise to RNAs coding for either four, three or two double zinc fingers, respectively. The main expression domains of Xsal-1 in early development are confined to distinct regions along the lateral axon tracts within the midbrain, hindbrain, and spinal cord. Outside the central nervous system Xsal-1 is expressed in the facio-acoustic ganglion and in the developing limb buds. The pattern of expression suggests that Xsal-1 might be under control of signals emanating from the notochord and/or the floor plate and that it might function in neuronal cell specification.
authors: Abteilung für Entwicklungsbiochemie, Universität Göttingen, Germany.
authors: T
authors: T
authors: Hollemann
authors: R
authors: R
authors: Schuh
authors: T
authors: T
authors: Pieler
authors: R
authors: R
authors: Stick
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002490:Central Nervous System / Q000196:embryology; D004330:Drosophila; D029721:Drosophila Proteins; D005091:Exons; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000737:chemistry* / Q000235:genetics; D007438:Introns; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics; D029867:Xenopus Proteins; D014982:Xenopus laevis; D016335:Zinc Fingers / Q000235:genetics
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C103405:sal1-A protein, Xenopus; C085793:salm protein, Drosophila; C484468:spalt protein, vertebrate