title: High-density gridding: techniques and applications.
abstract: Much progress has been made in the development of techniques for constructing dense grids either of ligands, such as peptides and oligonucleotides, or of cloned nucleic acids. Such arrays are finding practical applications in the analysis of sequence variation and gene expression. Methods for carrying out large numbers of analyses in parallel will be essential for the genetic programme that is developing from large-scale sequencing projects.
authors: Department of Biochemistry, University of Oxford, UK.
authors: E M
authors: EM
authors: Southern
mesh_terms: D000818:Animals; D001483:Base Sequence; D004252:DNA Mutational Analysis; D018076:DNA, Complementary; D015870:Gene Expression; D015723:Gene Library; D005821:Genetic Techniques; D006801:Humans; D007256:Information Systems; D008024:Ligands; D009841:Oligonucleotides; D010455:Peptides; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D018076:DNA, Complementary; D008024:Ligands; D009841:Oligonucleotides; D010455:Peptides