title: Potential of T2 relaxation time measurements for early detection of radiation injury to the brain: experimental study in pigs.
abstract: OBJECTIVE
  To investigate the MR T2 relaxation time and histologic changes after a single-fraction 25-Gy dose of radiation to the brain of pigs.
  
  
  METHODS
  The right hemisphere of 10 Meishan pigs was irradiated with a single dose of 25 GY at the 90% isodose, using a 12-MeV electron beam. T2 relaxation time was measured within three regions of interest in the brain: those that had received 90%, 70%, and 40% of the total dose, respectively. T2 kinetics over time was compared with histologic studies.
  
  
  RESULTS
  Brain T2 values were noted to increase within the irradiated areas. T2 kinetics were analyzed in three phases: an immediate transient phase and two long-lasting phases. These two long-lasting phases were correlated with the detection of ventricular compression and necrosis, respectively. The T2 increase within the 90% region of interest was 19%, 22%, and 26% for phases I, II, and III, respectively. T2 measurements within other regions of interest were not significant.
  
  
  CONCLUSIONS
  Although our results suggest a dose threshold for T2 variations, brain T2 values increased after irradiation at a level at which disease could not be seen on conventional MR images. This illustrates the value of using conventional MR imaging in a quantitative manner to assess molecular tissue abnormalities at earlier stages of developing diseases.
authors: Laboratoire de Biophysique Cellulaire et RMN, Tours, France.
authors: E
authors: E
authors: Miot-Noirault
authors: S
authors: S
authors: Akoka
authors: D
authors: D
authors: Hoffschir
authors: D
authors: D
authors: Pontvert
authors: G
authors: G
authors: Gaboriaud
authors: C
authors: C
authors: Alapetite
authors: F
authors: F
authors: Fetissof
authors: A
authors: A
authors: Le Pape
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D001929:Brain Edema / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology / Q000528:radiation effects; D002831:Choroid Plexus / Q000473:pathology; D004307:Dose-Response Relationship, Radiation; D008264:Macrophages / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008581:Meningitis / Q000473:pathology; D009336:Necrosis; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000175:diagnosis* / Q000473:pathology; D011879:Radiotherapy Dosage; D013552:Swine; D013997:Time Factors