[The immunopathology and immunogenetics of some forms of pediatric epilepsy].
52 patients with primary and 42 with secondary generalized epilepsy at the age of 2-16 years were examined. In all the patients blood content of T- and B-lymphocytes as well as of their subpopulations (T-helpers, T-suppressors) was estimated with the use of monoclonal antibodies. Immunogenetic studies of allogenic lymphocytes were also performed in mixed lymphocyte cultures for proband and mother. There was an increase of CD4/CD8 ratio (T-helper/T-suppressor) as well as elevation of B-lymphocytes level in patients with secondary generalized form of epilepsy. A positive reaction of allogenic lymphocytes from mother and child in mixed cultures was observed in 46 patients with primary generalized epilepsy (88.5%), in 16 cases with progredient disease. In secondary generalized form of epilepsy it occurred in 7 cases only (16.7%). In 28 cases of epilepsy with progredient course not only antiepileptic drugs but also immunomodulators were used with positive effect in 14 patients.
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D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D004829:Epilepsy, Generalized / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007125:Immunogenetics; D013601:T-Lymphocytes / Q000276:immunology
Immunopatologiia i immunogenetika nekotorykh form detskoĭ épilepsii.