title: Novel MR image contrast mechanisms in epilepsy.
abstract: A range of magnetic resonance (MR) parameters are introduced, which can give rise to image contrast by using suitable pulse sequences, and that can be measured quantitatively. Their relationship to tissue pathology is given as far as possible. Techniques for their measurement, and results from multiple sclerosis, stroke, and epilepsy are given. The parameters are proton density, T1, T2, transverse magnetisation decay, which gives estimates of extracellular water and myelin concentrations, magnetisation transfer ratio and T1sat, and diffusion (including trace and anisotropy measured from the tensor matrix).
authors: Institute of Neurology, Queen Square, London, UK.
authors: P S
authors: PS
authors: Tofts
mesh_terms: D016880:Anisotropy; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000473:pathology; D003287:Contrast Media / Q000493:pharmacokinetics; D004058:Diffusion; D004827:Epilepsy / Q000175:diagnosis* / Q000473:pathology; D005110:Extracellular Space; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology
chemical_list: D003287:Contrast Media