title: Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities.
abstract: The norditerpenoid alkaloid lycaconitine (2) was synthesized from lycoctonine (3) and its affinity determined for two neuronal nicotinic acetylcholine receptor subtypes. The structure of 2 was confirmed by a combination of spectroscopic methods.
authors: College of Pharmacy, Ohio Northern University, Ada 45810, USA.
authors: J M
authors: JM
authors: Jacyno
authors: J S
authors: JS
authors: Harwood
authors: N H
authors: NH
authors: Lin
authors: J E
authors: JE
authors: Campbell
authors: J P
authors: JP
authors: Sullivan
authors: M W
authors: MW
authors: Holladay
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
chemical_list: D000470:Alkaloids; D011978:Receptors, Nicotinic; C101813:lycaconitine