title: Evaluation of the importance of maternal history of diabetes and of mitochondrial variation in the development of NIDDM.
abstract: In 79 South Indian nuclear pedigrees ascertained via probands with NIDDM and both parents living, parental diabetic status was established through previously diagnosed NIDDM (n = 97) or oral glucose tolerance testing (n = 61). There was no significant difference between diabetes prevalence in mothers and fathers (60 vs 53 (76% vs 67%), respectively, p = 0.22). 'Age at diabetes diagnosis' survival curves did differ according to parental gender (p = 0.02) but this may reflect gender differences in health provision rather than pathophysiology. No maternal excess effects of the magnitude evident in previous studies were detected, suggesting either ethnic differences or overestimation of the maternal effect when reported histories of parental diabetes have been used. The tRNA(Leu(UUR) gene region was studied for diabetes-associated variation given the role of mutations in this gene in some pedigrees displaying maternal transmission of NIDDM. None of 142 unrelated South Indian NIDDM subjects displayed the MELAS mutation at nt3243. However, sequencing identified two variants of potential importance: (a) at nt3290 in the tRNA(Leu(UUR) gene, seen in 7/142 diabetic and 1/85 control subjects (p = 0.11), (b) at nt3316 in the ND1 gene (4/142 vs 1/85 subjects, respectively (p = 0.51)). Further studies are needed to determine the relevance of these variants to the development of NIDDM.
authors: Medical Unit, London Hospital Medical College, UK.
authors: M
authors: M
authors: McCarthy
authors: P
authors: P
authors: Cassell
authors: T
authors: T
authors: Tran
authors: L
authors: L
authors: Mathias
authors: L M
authors: LM
authors: 't Hart
authors: J A
authors: JA
authors: Maassen
authors: C
authors: C
authors: Snehalatha
authors: A
authors: A
authors: Ramachandran
authors: M
authors: M
authors: Viswanathan
authors: G A
authors: GA
authors: Hitman
mesh_terms: D000328:Adult; D017668:Age of Onset; D003062:Codon; D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality; D005006:Ethnicity; D005220:Fathers; D005260:Female; D014644:Genetic Variation; D018392:Genomic Imprinting; D006801:Humans; D007194:India; D017241:MELAS Syndrome / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009035:Mothers; D015999:Multivariate Analysis; D009679:Nuclear Family; D010375:Pedigree; D015995:Prevalence; D012356:RNA, Transfer, Leu / Q000235:genetics*; D012727:Sex Characteristics; D015996:Survival Rate
chemical_list: D003062:Codon; D004272:DNA, Mitochondrial; D012356:RNA, Transfer, Leu