The DNA-dependent protein kinase: a matter of life and (cell) death.
The catalytic subunit of the DNA-dependent protein kinase (DNA-PK) is a member of the phosphatidylinositol 3-kinase family. Recent genetic and biochemical studies indicate the involvement of DNA-PK in immunoglobulin/T-cell-receptor gene recombination, double-strand DNA break repair, the stress response and autoimmunity. A role in the suppression of apoptosis could link some of the enzyme's diverse functions.
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Medical College of Georgia, Institute for Molecular medicine & Genetics, Augusta 30912-3175, USA. Dynan@immag.mcg.edu
Dynan
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D000818:Animals; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000502:physiology
D004268:DNA-Binding Proteins; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases