Differences in the induction of carboxylesterase RL4 in rat liver microsomes by various perfluorinated fatty acids, metabolically inert derivatives of fatty acids.
Differences in the ability of metabolically inert peroxisome proliferators [perfluoro-n-decanoic acid (PFDA, C10), perfluoro-n-octanoic acid (PFOA, C8), perflorooctane sulfonic acid (PFOS, C8) and 1H,1H-pentadecafluoro-n-octanol (PFOL, C8)] to induce liver microsomal carboxylesterase RL4 in male rats were studied by evaluating changes in the RL4 content by immunoblot analysis with a specific antibody. The administration of PFOA, PFOS and PFOL markedly increase the content of carboxylesterase RL4. On the other hand, PFDA decreases PNPA, BUTA, and ISOC hydrolase activity, and slightly increases the carboxylesterase RL4 content.
Derbel
M
M
Laboratory of Biochemical Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Hosokawa
M
M
Satoh
T
T
D017738:Alkanesulfonic Acids / Q000494:pharmacology; D000818:Animals; D002210:Caprylates / Q000494:pharmacology; D002265:Carboxylic Ester Hydrolases / Q000096:biosynthesis*; D003652:Decanoic Acids / Q000494:pharmacology; D004790:Enzyme Induction; D005227:Fatty Acids / Q000494:pharmacology*; D005466:Fluorocarbons / Q000494:pharmacology*; D015151:Immunoblotting; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011916:Rats, Inbred F344; D012997:Solvents / Q000494:pharmacology; D013379:Substrate Specificity
D017738:Alkanesulfonic Acids; D002210:Caprylates; D003652:Decanoic Acids; D005227:Fatty Acids; D005466:Fluorocarbons; D007527:Isoenzymes; D012997:Solvents; C036567:perfluorodecanoic acid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid; D002265:Carboxylic Ester Hydrolases