The effect of non-activated prothrombin complex concentrate (Proplex ST) on intraperitoneal hematoma in a hemophilia A patient with a factor VIII inhibitor.
A 28-year-old severe hemophiliac with a factor VIII inhibitor was admitted to our hospital with a massive and serious intraperitoneal hematoma. He was a high-responder patient showing maximal serum inhibitor levels as high as 255 Bethesda Units/ml (BU/ml). He was successfully treated with "bypass therapy" using a prothrombin complex concentrate (PCC).
Kagawa
H
H
First Department of Internal Medicine, Kansai Medical University, Osaka.
Yasuzawa
M
M
Ozaki
Y
Y
Yamamoto
Y
Y
Katsurada
T
T
Nomura
S
S
Okubo
S
S
Fukuhara
S
S
D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D005169:Factor VIII / Q000037:antagonists & inhibitors; D006406:Hematoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010532:Peritoneal Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D005169:Factor VIII