title: Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves.
abstract: A new conduit made with a bioabsorbable copolymer, poly (L-lactide-co-6-caprolactone), was evaluated in an animal model as a guide for nerve regeneration. The conduit had an inner diameter of 1.3 mm and a wall thickness of 175 microns. Segments of length 1.2 cm were interposed between the proximal and distal stumps of transected ischiatic nerves in Wistar rats, bridging a nerve gap of 1 cm. All of the procedure was performed under general anaesthesia using microsurgical techniques. Controls were performed at 1, 3 and 6 months and it was demonstrated that the conduit was still undamaged after 30 d. Progressive signs of degradation appeared at 90 and 180 d. Nerve regeneration in the lumen was effective as confirmed by histological and electron microscopical investigations. These preliminary results emphasize the interesting properties of the conduit with regard to the achievement of a neural prosthesis.
authors: Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti I.O.R., Bologna, Italy.
authors: N
authors: N
authors: Nicoli Aldini
authors: G
authors: G
authors: Perego
authors: G D
authors: GD
authors: Cella
authors: M C
authors: MC
authors: Maltarello
authors: M
authors: M
authors: Fini
authors: M
authors: M
authors: Rocca
authors: R
authors: R
authors: Giardino
mesh_terms: D000042:Absorption; D000818:Animals; D001672:Biocompatible Materials; D005069:Evaluation Studies as Topic; D008297:Male; D009416:Nerve Regeneration; D010525:Peripheral Nerves / Q000502:physiology* / Q000601:surgery*; D011091:Polyesters; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C062968:lactide-caprolactone copolymer