Has nicotine a local anaesthetic action?
In this study, we investigated whether nicotine may have a local anaesthetic action in mice, using the tail press and tail immersion tests. Nicotine increased the latent time of biting the clip in the tail press test (p < 0.001) and retarded tail withdrawal latency in the tail immersion test (p < 0.01), compared to controls. These results suggest that nicotine may possess a local anaesthetic action.
Erenmemisoglu
A
A
Department of Pharmacology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Suer
C
C
Temocin
S
S
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007101:Immersion; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D018733:Nicotinic Antagonists / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010947:Plants, Toxic; D011318:Prilocaine / Q000494:pharmacology; D014030:Tobacco, Smokeless
D000779:Anesthetics, Local; D018733:Nicotinic Antagonists; D011318:Prilocaine; D008464:Mecamylamine; D009538:Nicotine