[Effects of neferine on the 45Ca-influx and efflux induced by activation of alpha-1 adrenoceptor of vascular smooth muscle].
Experiments have shown that in the vascular smooth muscle neferine (Nef) can markedly reduce the 45Ca-influx induced by phenylephrine, but does not affect the 45Ca-influx induced by mmol/L KCl, which is almost completely inhibited by nifedipine. Neferine does not inhibit 45Ca-efflux.
Wang
Y
Y
Xuzhou Municipal Institute of Medical Sciences Jiangsu.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004285:Dogs; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D010656:Phenylephrine / Q000037:antagonists & inhibitors; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism; D014665:Vasodilator Agents / Q000494:pharmacology*
D000470:Alkaloids; D044182:Benzylisoquinolines; D018340:Receptors, Adrenergic, alpha-1; D014665:Vasodilator Agents; D010656:Phenylephrine; C057222:neferine; D002118:Calcium