Effect of the intraperitoneal administration of salmon-calcitonin on the "in vitro" actions of opioid agonists.
1. The interaction of intraperitoneal administration of salmon-calcitonin with opioids was studied. The study was carried out using guinea pig ileum (mu and kappa-opioid receptors), rabbit vas deferens (kappa-opioid receptors) and mouse vas deferens (delta-opioid receptors), and selective mu, delta and kappa agonists were used in the pertinent tissues. 2. The treatment with salmon-calcitonin increased, in a dose-dependent manner, the effect of U-50,488H in guinea pig ileum and rabbit vas deferens and the effects of [D-Pen2, D-Pen5] enkephalin in mouse vas deferens. 3. The treatment with analgesic doses of salmon-calcitonin enhances the in vitro effects of kappa- and delta-opioid agonists. The increase of the effectiveness of the opioid agonists may be one of the mechanisms involved on the analgesia induced by salmon-calcitonin.
Martin
M I
MI
Departamento de Farmacologia, Facultad de Medicina, U. Complutense, Madrid, Spain.
Goicoechea
C
C
Ormazabal
M J
MJ
Alfaro
M J
MJ
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009294:Narcotics / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology; D011817:Rabbits; D017465:Receptors, Opioid, delta / Q000187:drug effects; D017473:Receptors, Opioid, kappa / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
D000700:Analgesics; D004745:Enkephalins; D009294:Narcotics; D011759:Pyrrolidines; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; C028815:salmon calcitonin; D002116:Calcitonin