[A new class of small RNP (alpha-RNP) containing antisense RNA in K-562 cells. I. Their characteristics and changes during erythroid differentiation].
A new class of small RNP (alpha-RNP) has been detected and identified in nuclei and cytoplasm of A-562 erythroid leukemia cell line; these RNPs have a characteristic spectrum of proteins containing conservative and specific components and a special RNA component, which contains a small antisense component (alpha-RNA), a homolog of short dispersed Alu repeats. alpha-RNP is highly stable, tightly associated with chromatin in the nucleus, and is found in the free state in cytoplasm. The composition of nuclear and cytoplasmic alpha-RNP differ and have a specific pattern of changes in response to dimethylsulfoxide, an agent causing differentiation.
Konstantinova
I M
IM
Petukhova
O A
OA
Kulikova
V A
VA
Turoverova
L V
LV
Volkova
I V
IV
Ignatova
T N
TN
Kozhukharova
I V
IV
Ermolaeva
Iu B
IuB
Gauze
L N
LN
D002454:Cell Differentiation / Q000187:drug effects; D002467:Cell Nucleus / Q000737:chemistry / Q000187:drug effects; D003593:Cytoplasm / Q000737:chemistry / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics; D016372:RNA, Antisense / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D012334:RNA, Neoplasm / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D017411:Ribonucleoproteins, Small Nuclear / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D014407:Tumor Cells, Cultured
D016372:RNA, Antisense; D012334:RNA, Neoplasm; D017411:Ribonucleoproteins, Small Nuclear; D004121:Dimethyl Sulfoxide
Novyĭ klass malykh RNP (al'fa-RNO), soderzhashchokh antismyslovuiu RNK, v kletkakh linii K-562. I. Kharakteristika i izmeneniia pri differentsirovke po éritroidnomu puti.