Serum levels of RIST, RAST, and cortisol of patients with allergic rhinitis.
It is generally known that in Type 1 allergy, adrenal steroid hormonesregulate the production of IgE antibody. This study was carried out to determine whether patients with rhinitic allergy to Japanese cedar pollencan modulate the interaction between the immune and endocrine systems normally. The subjects were 61 patients allergic to Japanese cedar pollen, and 14 healthy volunteers served as control. Our study suggests that downregulation of the HPA axis may be caused by high specific and non-specific IgE production in patients with allergic rhinitis, Our data suggest that cortisol may play a role as an immuno-suppressive agent in specific IgE production during the pollen season, as this phenomenon was not observed before or after the pollen season.
Uesugi
K
K
Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki, Japan.
Urushibata
T
T
Miho
H
H
Takeyama
I
I
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood*
D007073:Immunoglobulin E; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone