Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
A crossover, double-blind trial was conducted using eleven healthy volunteers to determine whether and the degree to which acute drug tolerance occurred to the subjective, cognitive, and psychomotor effects of a range of subanesthetic nitrous oxide doses (0, 10, 20, 30, and 40%). There was little evidence of acute drug tolerance to the subjective measures or to the cognitive/psychomotor impairing effects of nitrous oxide at any of the concentrations tested over the course of the 120-min inhalation.
Yajnik
S
S
Department of Anesthesia and Critical Care, University of Chicago, Pritzker School of Medicine, IL 60637, USA.
Zacny
J P
JP
Young
C J
CJ
Lichtor
J L
JL
Rupani
G
G
Klafta
J M
JM
Coalson
D W
DW
Apfelbaum
J L
JL
D000280:Administration, Inhalation; D000328:Adult; D000339:Affect / Q000187:drug effects*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000187:drug effects*
D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide; D010100:Oxygen