Molecular heterogeneity in childhood precursor B acute lymphoblastic leukemia with immunoglobulin heavy chain gene in germline configuration.
Four childhood acute leukemias with morphological, cytochemical and immunological characteristics correlating to precursor B lymphocyte and with germline configuration of the immunoglobulin heavy chain joining region were studied for the organization of the C mu segment. Two of the four lymphoblast samples retained the germline configuration of both JH and C mu regions. The other two samples showed delection of the entire JH region resulting in the rearrangement of the C mu region. In contrast to patients with C mu rearrangement, patients with C mu in germline form were not able to achieve complete remission after induction therapy. Study of the C mu region in patients with JH segment in germline configuration could separate subgroups in childhood precursor B acute lymphoblastic leukemia with different prognoses.
Roman Gomez
J
J
Department of Hematology, Reina Sofia Hospital, Cordoba, Spain.
Andres
P
P
Garcia
M J
MJ
Flores
R
R
Jimenez
M A
MA
Martin
C
C
De La Torre
M J
MJ
Sanchez
J
J
Garcia
J M
JM
Torres
A
A
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D015139:Blotting, Southern; D001853:Bone Marrow / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007133:Immunoglobulin Joining Region / Q000235:genetics; D016130:Immunophenotyping; D007223:Infant; D015183:Restriction Mapping
D015703:Antigens, CD; D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains; D007133:Immunoglobulin Joining Region