Effect of metoclopramide on muscle sympathetic nerve activity in humans.
The aim of this study was to determine the effect of metoclopramide on the sympathetic nervous system. Muscle sympathetic nerve activity was increased in two stages after metoclopramide injection. The initial increase in sympathetic nerve activity may result from the unloading of arterial baroreceptors because there was a negative correlation between mean blood pressure and muscle sympathetic nerve activity. The later increase in muscle sympathetic nerve activity may be attributed to the central activation of the sympathetic nervous system because there was a positive correlation between mean blood pressure and muscle sympathetic nerve activity. These results suggest that metoclopramide activates the sympathetic nervous system by two different mechanisms.
Takeuchi
Y
Y
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
Matsukawa
T
T
Sugiyama
Y
Y
Iwase
S
S
Mano
T
T
D000320:Adrenergic Fibers / Q000187:drug effects*; D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D017776:Autonomic Pathways / Q000166:cytology / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004594:Electrophysiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D009132:Muscles / Q000294:innervation*; D009638:Norepinephrine / Q000097:blood; D009997:Osmotic Pressure / Q000187:drug effects
D001127:Arginine Vasopressin; D008787:Metoclopramide; D009638:Norepinephrine