Accumulation of 99Tcm-polyclonal immunoglobulin in different stages of infection: an experimental study.
In this experimental study, the utility of 99Tc(m)-polyclonal human immunoglobulin (99Tcm-HIG) for localizing acute and chronic phases of inflammatory lesions was investigated. Three groups of rats were inoculated with Staphylococcus aureus in the right thigh. Then, 24 h (group I, n = 12), 48 h (group II, n = 12) and 72 h (group III, n = 12) post-inoculation, the rats received 40 MBq 99Tcm-HIG into the jugular vein. In addition, two control rats were studied at 24 h after inoculation of sterile saline. Both visual and quantitative evaluations were undertaken. The acute and chronic stages of inflammation were determined by pathological examination. The mean ( +/- S.D.) lesion/contralateral uptake ratios at 4 and 24 h after 99Tcm-HIG injection were: group I, 1.22 +/- 0.1 and 2.12 +/- 0.16; group II, 1.15 +/- 0.08 and 2.25 +/- 0.16; group III, 1.06 +/- 0.09 and 2.08 +/- 0.14. In conclusion, the acute and chronic phases of infection showed non-significant differences in 99Tcm-HIG uptake ratios.
Burak
Z
Z
Department of Nuclear Medicine, Ege University Medical Faculty, Izmir, Turkey.
Ozcan
Z B
ZB
Ozcan
C
C
Ozacar
T
T
Başdemir
G
G
Erdem
S
S
Argon
M
M
Erdener
A
A
Duman
Y
Y
D000038:Abscess / Q000000981:diagnostic imaging / Q000503:physiopathology; D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D015902:Gamma Cameras; D006801:Humans; D007136:Immunoglobulins / Q000494:pharmacology*; D007249:Inflammation; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013211:Staphylococcus aureus; D013667:Technetium / Q000494:pharmacology*
D007136:Immunoglobulins; C065376:technetium Tc 99m immunoglobulin; D013667:Technetium