Long-term stability of cimetidine in total parenteral nutrition.
The stability of cimetidine (Tagamet) was investigated in total parenteral nutrition (TPN) mixtures containing different amino acid sources. TPN mixtures were stored at 5 degrees C in ethylvinyl acetate bags for 28 days and analysed by stability-indicating high-pressure liquid chromatography. Results indicated that cimetidine was physically compatible and chemically stable (less than 5% degradation) for at least 28 days in TPN mixtures containing either Freamine III, Vamin 14 or Aminoplex 12 as the amino acid source.
Allwood
M C
MC
Medicines Research Unit, School of Health and Community Studies, University of Derby, U.K.
Martin
H J
HJ
D000596:Amino Acids / Q000008:administration & dosage; D002927:Cimetidine / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D010289:Parenteral Nutrition, Total; D013997:Time Factors
D000596:Amino Acids; D006635:Histamine H2 Antagonists; D002927:Cimetidine