Production of superoxide dismutases from Proteus mirabilis and Proteus vulgaris.
Proteus mirabilis and Proteus vulgaris expressed a combination of superoxide dismutase (Sod) activities, which was assigned to FeSod1, FeSod2 and MnSod for P. mirabilis, and FeSod, MnSod and CuZnSod for P. vulgaris. Production of the Sod proteins was dependent on the availability of iron, whether cells were grown under anaerobiosis or aerobiosis and growth phase. Nalidixic acid and chloramphenicol inhibited cell growth and the iron- and dioxygen-dependent production of Sod. These results support the involvement of metal ions and redox status in the production of Proteus Sods.
Dayton
T M
TM
Department of Chemistry, Southern Illinois University of Carbondale, USA.
Diefenbach
K A
KA
Fuller
M L
ML
Valtos
J
J
Niederhoffer
E C
EC
D000332:Aerobiosis; D000693:Anaerobiosis; D002701:Chloramphenicol / Q000494:pharmacology; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D009268:Nalidixic Acid / Q000494:pharmacology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D011514:Proteus vulgaris / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000378:metabolism
D009268:Nalidixic Acid; D002701:Chloramphenicol; D007501:Iron; D013482:Superoxide Dismutase; D010100:Oxygen