Increased platelet aggregability in patients with vertigo, sudden deafness and facial palsy.
Many patients suffering from episodic vertigo have no cochlear symptoms. These patients have so far been diagnosed as having Meniere's disease of the vestibular type. However, the underlying mechanisms are still to be established. In the present study, we investigated platelet aggregability in patients with dizziness, Meniere's disease, sudden deafness and facial palsy, to examine whether abnormalities in platelet aggregation is one of the causes of episodic vertigo. In 36 patients with dizziness, in 13 with Meniere's disease, in 7 sudden deafness, and in 7 facial palsy, platelet aggregability to adenosine diphosphate (ADP) was assessed by optometric technique. It was found that platelet aggregability was increased in the patients with dizziness as well as with Meniere's disease, sudden deafness and facial palsy and only the two former patient groups showed a tendency of hyperlipidemia. The administration of antiplatelet and lipidemia drugs resulted in no recurrence of vertigo during at least 3 months' follow-up. Hence, the results of our study suggest that a possible initializing factor of vertigo without cochlear symptoms might be disturbed microcirculation due to platelet hyperaggregability.
Asakura
M
M
Department of Otolaryngology, St. Marianna University, School of Medicine, Kawasaki, Japan.
Kato
I
I
Takahashi
K
K
Okada
T
T
Minami
S
S
Takeyama
I
I
Ohnuki
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D005158:Facial Paralysis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage; D008297:Male; D008575:Meniere Disease / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D012008:Recurrence; D012307:Risk Factors; D014717:Vertigo / Q000097:blood* / Q000188:drug therapy
D000960:Hypolipidemic Agents; D010975:Platelet Aggregation Inhibitors