title: Modulation of the phenotypic diversity of sickle cell anemia.
abstract: Sickle cell anemia is noted for being phenotypically heterogeneous. This suggests that there are genetic influences that moderate the effects of the sickle hemoglobin mutation. In this review I focus on genetically determined modulation of hemoglobin concentration and fetal hemoglobin levels. Each of these variables has important influences upon sickle hemoglobin polymerization and the resulting pathophysiology.
authors: Department of Medicine, University of Mississippi School of Medicine, Jackson 39216, USA.
authors: M H
authors: MH
authors: Steinberg
mesh_terms: D000755:Anemia, Sickle Cell / Q000235:genetics*; D005319:Fetal Hemoglobin / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D010641:Phenotype; D017085:alpha-Thalassemia / Q000235:genetics*
chemical_list: D005319:Fetal Hemoglobin