[A study on the appearance of hepatitis B virus markers in renal tissue of glomerulonephritis].
HBV antigens (HBcAg, HBsAg and HBeAg) in 246 cases of renal biopsy specimens with various types of glomerulonephritis were examined by immunohistochemical techniques. Southern blot hybridization was used to detect HBV DNA in 18 cases. The results showed that HBV antigens were frequently found in the tubular cells in addition to the appearance of HBV antigens on the glomeruli of certain glomerulonephritis. The positive rte of HBcAg in the tubular cells was 21.54%, which is higher than that of glomeruli (10.98%). Renal HBV DNA was positive in 15 cases and among them HBcAg expression in renal tissue in 14 cases and HBV antigenemia in 12 cases. The results suggest that HBV may also be implicated in the pathogenesis of certain cases of glomerulonephritis and the appearance of HBV antigen antibody immunocomplex in renal tissue, aside from originating in the circulation, there is the possibility of it originating from renal cells in situ.
Zhou
S
S
Department of Pathology, Shanghai Medical University.
Zhang
Y
Y
Fang
L
L
D015415:Biomarkers / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis*; D005921:Glomerulonephritis / Q000821:virology*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D007678:Kidney Glomerulus / Q000821:virology*; D007684:Kidney Tubules / Q000821:virology*
D015415:Biomarkers; D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens