Angiotensin converting enzyme inhibition and protein restriction in progression of experimental chronic renal failure.
This study examined whether the effects of protein restriction and angiotensin converting enzyme (ACE) inhibition on the progression of renal failure are common or additive. Male Sprague Dawley rats (12 wks of age) underwent 5/6 nephrectomy and were randomized to 20% protein diet (PD) (n = 9), 20% PD+enalapril (5 mg/kg/day) (n = 10), 20% PD+felodipine (30 mg/kg/day) (n = 9), 6% PD (n = 9), 6% PD+enalapril (n = 9) or 6% PD+felodipine (n = 10). Protein restriction, enalapril or felodipine treatment all retarded progression of renal failure and development of glomerular lesions. Protein restriction and enalapril appeared to have additive effects in preventing glomerular sclerosis.
Liu
D T
DT
Department of Medicine, University of NSW, St George Hospital, Kogarah.
Turner
S W
SW
Wen
C
C
Whitworth
J A
JA
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000633:toxicity*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D007676:Kidney Failure, Chronic / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects; D011488:Protein Deficiency / Q000201:enzymology / Q000473:pathology*; D011502:Protein-Energy Malnutrition / Q000201:enzymology / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000806:Angiotensin-Converting Enzyme Inhibitors