[Nerve transplantation in the central nervous system: a strategy for inducing nerve fiber regeneration in lesions of the brain and spinal cord].
Nerve grafts have long been used as a reconstructive strategy in the human peripheral nervous system. In the nervous system (brain and spinal cord), peripheral nerve grafts have been used experimentally for promoting axonal regeneration in lesioned pathways. Peripheral nerve grafts play the role of physical and trophic supports that are favourable for the regeneration of central fibres that normally present only abortive regeneration in adult mammals. On the basis of several experimental models (axonal regeneration of retinal ganglion cells, respiratory neurones, ...) it has now been established that central fibres that have regenerated within the nerve grafts retain their ability to transmit normal nervous information and can make functional synaptic contact with a target. If such a strategy is not yet used in man, it nevertheless constitutes a promising approach for the investigation of the central nervous system plasticity, and could be useful in the treatment of spinal cord injuries.
Gauthier
P
P
Département de Physiologie et de Neurophysiologie, CNRS URA 1832, Faculté des Sciences et des Techniques de Saint-Jérôme, Marseille.
Decherchi
P
P
Réga
P
P
Lammari-Barreault
N
N
D000328:Adult; D001369:Axons / Q000502:physiology*; D001930:Brain Injuries / Q000601:surgery*; D002490:Central Nervous System / Q000502:physiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009416:Nerve Regeneration; D009474:Neurons / Q000502:physiology; D010525:Peripheral Nerves / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000601:surgery*
Transplantation de nerf dans le système nerveux central: une stratégie pour provoquer la repousse des fibres nerveuses lors de lésions du cerveau et de la moelle épinière.