Adrenocortical function in the domestic cat during treatment with levonorgestrel.
Levonorgestrel was administered via a subcutaneous, slow-release silastic implant to 10 queens. Five other queens served as controls. Their adrenocortical function was assessed by the adrenocorticotrophic hormone (ACTH) stimulation test before and after one, two, six and 12 months of treatment. In addition, the gross anatomy and histology of the adrenal gland were examined post mortem in six of the treated cats. In both the control and treated queens the plasma cortisol concentrations (pre and post ACTH) were significantly different (P < 0.05) at different times. However, there were no significant differences between the plasma cortisol concentrations (pre and post ACTH) of the treated and control queens. No gross or microscopical abnormalities were visible in the adrenal glands of the treated queens.
Baldwin
C J
CJ
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011, USA.
Peter
A T
AT
Bosu
W T
WT
D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002415:Cats; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D004343:Drug Implants; D005260:Female; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D016912:Levonorgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D012016:Reference Values; D012826:Silicone Elastomers; D013997:Time Factors
D003280:Contraceptives, Oral, Synthetic; D004343:Drug Implants; D012826:Silicone Elastomers; D016912:Levonorgestrel; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone