Potentiation of lethal endotoxin shock by streptococcal pyrogenic exotoxin in rabbits: possible relevance of hyperreactivity of macrophages to endotoxin.
Streptococcal pyrogenic exotoxin (SPE) potentiates lethal shock induced by endotoxin. We have previously reported that macrophages derived from SPE-treated rabbits showed hyperreactivity to endotoxin, and that the effect of SPE on macrophages was mediated by a lymphokine(s). Here we show that culture supernatants of SPE-stimulated lymphocytes, when administered into rabbits three hours before or together with endotoxin, potentiate a variety of endotoxin-induced pathophysiological changes and even lethal shock. These results suggest that SPE-induced lymphokine(s) mediates the potentiating effect of SPE on the lethal endotoxin shock through enhancing endotoxin reactivity of macrophages which play the central role in mediating endotoxin toxicity.
Murai
T
T
National Institute of Health Sciences, Osaka, Japan.
Nakagawa
Y
Y
Ogawa
Y
Y
D000818:Animals; D001426:Bacterial Proteins; D001786:Blood Glucose / Q000032:analysis; D005098:Exotoxins / Q000494:pharmacology*; D005966:Glucuronidase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins; D011817:Rabbits; D012772:Shock, Septic / Q000209:etiology*
D001426:Bacterial Proteins; D001786:Blood Glucose; D005098:Exotoxins; D008054:Lipid Peroxides; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin; D005966:Glucuronidase