title: HLA antigens and asthma in Greeks.
abstract: HLA-A and -B antigens were determined in a group of 76 Greek asthmatic patients: 35 children (1.5-15 years) and 41 adults (18-73 years). The results were compared to those of 400 healthy unrelated controls from the same population. The standard NIH lymphocytotoxicity test was applied. When all 76 patients were compared to the controls, a statistically significant lower frequency of HLA-B5 and -B35 antigens was noted. When adults were analysed alone, an increased frequency of HLA-B8 was found. On the other hand, in the asthmatic children sub-group, the HLA-A10 antigen was significantly higher and the HLA-B5 was significantly lower than in the controls. These data imply that different HLA antigens may be involved in the pathogenesis of several clinical forms of asthma and that, in order to study the role of immunogenetic factor(s) in the pathogenesis of this disease, more adequate grouping criteria are needed.
authors: First University Department of Medicine, Laikon General Hospital, Athens, Greece.
authors: J
authors: J
authors: Apostolakis
authors: M
authors: M
authors: Toumbis
authors: K
authors: K
authors: Konstantopoulos
authors: D
authors: D
authors: Kamaroulias
authors: J
authors: J
authors: Anagnostakis
authors: V
authors: V
authors: Georgoulias
authors: P
authors: P
authors: Fessas
authors: J
authors: J
authors: Zervas
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006115:Greece; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015797:HLA-B35 Antigen / Q000032:analysis; D015795:HLA-B8 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D008875:Middle Aged
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; C039682:HLA-A10 antigen; D015235:HLA-B Antigens; D015797:HLA-B35 Antigen; C035270:HLA-B5 antigen; D015795:HLA-B8 Antigen