Microelectrophoretic application of SCH-23390 into the lateral septal nucleus blocks ethanol-induced suppression of LTP, in vivo, in the adult rodent hippocampus.
Ethanol intoxication produces deficits in the acquisition of new information and blocks the induction of hippocampal long-term potentiation (LTP), a candidate neurophysiological correlate for learning and memory. We report that, in adult rats, local application of the dopamine (DA) D1 receptor antagonist SCH-23390 into the lateral septum (LS) blocks ethanol-induced suppression of LTP and alterations of paired-pulse responses in the dentate gyrus. This suggests a primary role for an extra-hippocampal circuit and neurotransmitter system mediating ethanol's ability to suppress LTP.
Criado
J R
JR
Department of Neuropharmacology (CVN-13), Scripps Research Institute, La Jolla, CA 92037, USA.
Steffensen
S C
SC
Henriksen
S J
SJ
D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018891:Dentate Gyrus / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007478:Iontophoresis; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors
D001552:Benzazepines; D002492:Central Nervous System Depressants; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D000431:Ethanol; D004298:Dopamine