Inhibitory effect of lithium on cAMP dependent phosphorylation system.
The aim of the present study was to assess the direct effect of lithium on cAMP dependent phosphorylation. The results show that lithium, but not rubidium, at therapeutic and high concentrations significantly decreases the cAMP stimulated MAP2 endogenous phosphorylation in microtubule fraction. An inhibitory effect of lithium has also been found using purified heat stable microtubule proteins phosphorylated by the catalytic subunit of PKA. These data suggest a direct effect of lithium on the cAMP dependent protein kinase.
Mori
S
S
Center of Neuropharmacology, University of Milan, Italy.
Zanardi
R
R
Popoli
M
M
Smeraldi
E
E
Racagni
G
G
Perez
J
J
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002540:Cerebral Cortex / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D012413:Rubidium / Q000494:pharmacology
D002712:Chlorides; D008094:Lithium; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D012413:Rubidium; C032710:rubidium chloride; D015056:1-Methyl-3-isobutylxanthine