The influence of prolonged antidepressant treatment on the changes in cyclic AMP accumulation induced by excitatory amino acids in rat cerebral cortical slices.
We investigated the effect of prolonged electroconvulsive shock (ECS) or imipramine treatment on cyclic AMP accumulation induced by ibotenate and glutamate in rat cerebral cortical slices. Prolonged imipramine or electroconvulsive shock treatment attenuated the ibotenate-induced increase in cyclic AMP accumulation and inhibited the synergistic interaction between ibotenate and noradrenaline; the glutamate-mediated inhibition of forskolin-stimulated cyclic AMP accumulation was not modified. Our results indicate that multiple effects of excitatory amino acids on cyclic AMP accumulation are modified differently by antidepressant treatment.
Pilc
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Legutko
B
B
D000704:Analysis of Variance; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004347:Drug Interactions; D004597:Electroshock; D018698:Glutamic Acid / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D005576:Colforsin; D007051:Ibotenic Acid; D018698:Glutamic Acid; D000242:Cyclic AMP; D007099:Imipramine; D009638:Norepinephrine