title: Management of gastric cancer patients with synchronous hepatic metastasis: a retrospective study.
abstract: OBJECTIVE
  In order to improve the management of patients of gastric cancer with synchronous hepatic metastasis, their records were retrospectively studied.
  
  
  METHODS
  From January 1981 to July 1993, 558 gastric cancer patients were admitted in our institute. Twenty-five with synchronous hepatic metastasis were used in this study. Among these 25 patients, six had hepatic metastasis alone and nineteen had some other additional noncurative prognostic factors. For the primary lesion, 12 patients received gastrectomy (total or distal subtotal) and 13 patients did not. For the hepatic metastasis, 12 patients had regional therapy (hepatectomy or hepatic arterial chemotherapy) and 13 had not. Both gastrectomy and regional therapy for hepatic metastasis were carried out in 6 patients who had hepatic metastasis alone.
  
  
  RESULTS
  Five year cumulative survival rate was 9%. Survival rate of patients with hepatic metastasis alone was significantly better than the patients with additional noncurative factors (p < 0.05). The two long term survivors in this study had no other noncurative factors except hepatic metastasis.
  
  
  CONCLUSIONS
  Neither gastrectomy nor regional therapy for hepatic metastasis had beneficial effects on the patients with additional noncurative factors. Gastrectomy and regional therapy for hepatic metastasis should be performed in patients without additional noncurative factors.
authors: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors: M
authors: M
authors: Rafique
authors: W
authors: W
authors: Adachi
authors: S
authors: S
authors: Kajikawa
authors: M
authors: M
authors: Kobayashi
authors: S
authors: S
authors: Koike
authors: T
authors: T
authors: Kuroda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome