[In vivo tissue distribution of laryngeal cancer drained lymph node lymphocytes in tumor-bearing mice].
The distribution of 3H-TdR labeled human laryngeal cancer drained lymph node lymphocytes (LNL) to human laryngeal squamous cell carcinoma were traced in PHC3 bearing nude mice, and the radioactivity in tissues was detected. 30.7% labeled cells were localized in live in first day after transfer, and a few in lung, spleen and kidney. Labeled cells were reduced weekly and by the end of the fourth week there were still 4.3% in live, but very few were detected in the tumor site. This indicated that cancer drained LNL had no specificity to tumor, and could not infiltrate into tumor sites. So besides directly attacking tumor cells in vivo, possibly, there are some indirect mechanisms to mediate tumor regression.
Wu
Y
Y
First Hospital of Beijing Medical University.
Guo
M
M
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D017690:Cell Transplantation; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured