title: [C-myc activation by translocation in human primary non-small cell lung cancer].
abstract: OBJECTIVE
  Lung cancer is one of the most common human neoplasms. The carcinogenesis and development of lung cancer are related to activation and inactivation of many oncogenes and tumor-suppressor genes. We reported c-myc activation by translocation in SV40T-transformed human bronchial epithelial cells and lung cancer cell line before. In order to confirm that c-myc translocation exists in human primary non-small cell lung cancer, we continued our studies in 12 primary human lung cancers.
  
  
  METHODS
  We applied major fluorescence in situ hybridization (FISH) in combination with immunohistochemistry.
  
  
  RESULTS
  c-myc translocation was detected in two cases of the 12 primary lung cancers. Overexpression of c-myc was detected in the two cases by means of immunohistochemistry.
  
  
  CONCLUSIONS
  These results suggest that c-myc can be activated by translocation in human primary lung cancer.
authors: Cancer Institute, CAMS & PUMC, Beijing.
authors: Y
authors: Y
authors: Lu
authors: S
authors: S
authors: Cheng
authors: S
authors: S
authors: Guo
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D005786:Gene Expression Regulation; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D014178:Translocation, Genetic
chemical_list: D016271:Proto-Oncogene Proteins c-myc