Trophoblast antigen levels in the first trimester of a trisomy 22 pregnancy.
We report trophoblast antigen (pregnancy-associated plasma protein-A, PAPP-A; free beta-human chorionic gonadotrophin, F beta hCG) expression in a trimosy 22 pregnancy. Maternal concentrations of these antigens were depressed prior to detection of abnormalities by ultrasonography. Immunohistochemical findings were consistent with depressed marker expression.
Wheeler
D M
DM
Royal North Shore Hospital, Sydney, NSW, Australia.
Edirisinghe
W R
WR
Petchell
F
F
Yovich
J L
JL
Murch
A R
AR
Saunders
D M
DM
Sinosich
M J
MJ
D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis* / Q000097:blood; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D014314:Trisomy
D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A