Parkinson's disease affects automatic and spares intentional verbal learning. A stochastic approach to explicit learning processes.
We studied word list and paired associates learning in patients with idiopathic Parkinson's disease and normal controls by means of a two-stage stochastic model, which allows independent measurements of encoding, storage and retrieval abilities. We preliminarily ascertained that the model components were both sufficient and necessary to account for the overall performance of the subjects, and then compared the learning abilities between the two groups. Parkinson's disease patients were selectively impaired in identifying well-known engrams, for which learning is superfluous, and in automatic retrieval, namely in abilities that do not need attentional effort. By contrast, they were unimpaired in encoding and intentional retrieval, which require a purposeful effort. The automatic-voluntary dissociation of Parkinson's disease patients' motor behaviour is, therefore, paralleled by some features of their memory performance.
Faglioni
P
P
Clinica Neurologica, Università di Modena.
Scarpa
M
M
Botti
C
C
Ferrari
V
V
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D008960:Models, Psychological; D010153:Paired-Associate Learning / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D013269:Stochastic Processes; D014706:Verbal Learning / Q000502:physiology*
D000978:Antiparkinson Agents; D007980:Levodopa