d-fenfluramine's effects on normal ingestion assessed with taste reactivity measures.
The effects of d-fenfluramine on intake and on hedonic responses to taste stimuli in rats were investigated using a modified taste reactivity paradigm. Subjects (n = 15) were first trained to consume a 3% sucrose solution. They were then pretreated with d-fenfluramine (0.3-3.0 mg/kg, i.p.), and tested with access to either 3% sucrose, or a 0.01% quinine HCl solution. In the modified taste reactivity test, chronic oral cannulation was not used; instead, taste reactivity measures were scored during periods of noningestion in a voluntary intake test. d-Fenfluramine reliably reduced both sucrose and quinine consumption, and increased latency to drink at the highest dose. d-Fenfluramine also spared aversive responses to quinine, but reduced positive ingestive responses to sucrose. These results are consistent with an effect of d-fenfluramine to reduce taste palatability, which may, in turn, be an important factor in the effect of this drug on feeding motivation.
Gray
R W
RW
Laboratory of Experimental Psychology, School of Biological Sciences, University of Sussex, Falmer, Brighton, UK.
Cooper
S J
SJ
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D001067:Appetite Depressants; D005277:Fenfluramine; D013395:Sucrose; D011803:Quinine