[Tumor implantation in cicatrization sites following surgery for digestive cancers].
The natural history of surgically treated intraabdominal malignancy is such that a large proportion of patients present tumor recurrence at wound sites. Numerous factors operating within the wound environment are important determinants in tumor cells arrest or growth at these sites. This article describes the interactions between the traumatized tissues and tumor cells, and attempts to understand the important factors that may have an impact on implantation of cancer cells in wound sites. Modifications of these biologic factors may represent new perspectives for preventing tumor recurrence in intraabdominal wound sites.
Jacquet
P
P
Washington Cancer Institute, Washington, DC 20010, USA.
Elias
D
D
Sugarbaker
P H
PH
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D015815:Cell Adhesion Molecules; D017024:Chemotherapy, Adjuvant; D002921:Cicatrix; D004067:Digestive System Neoplasms / Q000556:secondary / Q000601:surgery*; D006801:Humans; D007274:Injections, Intraperitoneal; D010535:Laparoscopy / Q000009:adverse effects; D009364:Neoplasm Recurrence, Local; D009366:Neoplasm Seeding; D051381:Rats; D014945:Wound Healing
D000970:Antineoplastic Agents; D015815:Cell Adhesion Molecules
L'implantation tumorale dans les sites de cicatrisation après chirurgie des cancers digestifs.