Interleukin-6 (IL-6) in patients with Behçet's disease.
We have examined the levels of interleukin-6 (IL-6) in plasma and supernatants of peripheral blood mononuclear cells (PBMC) from patients with Behçet's disease and healthy controls using a sensitive enzyme-linked immunosorbent assay (ELISA). Plasma IL-6 level was not detected in any subjects. The IL-6 concentrations in culture supernatants of patients with active Behçet's disease were significantly high compared with patients with inactive disease and healthy controls. Moreover, we investigated IL-6 gene expression in cultured PBMC from patients with Behçet's disease. IL-6 gene expression was enhanced in active patients compared with inactive patients. These results show that IL-6 may play a role in the pathogenesis of Behçet's disease.
Yamakawa
Y
Y
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Sugita
Y
Y
Nagatani
T
T
Takahashi
S
S
Yamakawa
T
T
Tanaka
S
S
Nakamura
S
S
Ohno
S
S
Sekihara
H
H
Okuda
K
K
Nakajima
H
H
D000328:Adult; D001483:Base Sequence; D001528:Behcet Syndrome / Q000097:blood / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
D015850:Interleukin-6