Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants.
In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazono-2- indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, 1H-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against pentylenentetrazole induced seizures.
Gürsoy
A
A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Karali
N
N
Büyüktimkin
S
S
Demirayak
S
S
Ekinci
A C
AC
Ozer
H
H
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000927:Anticonvulsants; D006835:Hydrazones; D007211:Indoles; D010433:Pentylenetetrazole