Precise localization of the human gene encoding cell adhesion kinase beta (CAK beta/PYK2) to chromosome 8 at p21.1 by fluorescence in situ hybridization.
Cell adhesion kinase beta (CAK beta) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily with large N- and C-domains in addition to the central kinase domain. The cDNA of the human CAK beta has been cloned and used as a probe for the assignment of this gene by fluorescence in situ hybridization. CAK beta is sublocalized on chromosome 8p21.1, a locus frequently involved in allelic losses in colorectal cancers and prostate carcinomas.
Inazawa
J
J
Department of Hygiene, Kyoto Prefectural University of Medicine, Japan.
Sasaki
H
H
Nagura
K
K
Kakazu
N
N
Abe
T
T
Sasaki
T
T
D000818:Animals; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D015179:Colorectal Neoplasms / Q000235:genetics; D015342:DNA Probes; D018076:DNA, Complementary; D051418:Focal Adhesion Kinase 2; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008969:Molecular Sequence Data; D011471:Prostatic Neoplasms / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D051381:Rats
D015342:DNA Probes; D018076:DNA, Complementary; D011505:Protein-Tyrosine Kinases; D051418:Focal Adhesion Kinase 2; C496054:Ptk2b protein, rat