[Heart-lung transplantation and cystic fibrosis. Indications and results].
BACKGROUND
Heart lung transplantation for++ cystic fibrosis is now performed in patients with severe lung disease but the experience is still scarce with the exception of some specialized centers.


METHODS
Twenty-one patients underwent heart-lung transplantation between September 1989 and November 1994 in our institution, with a high standard of reliability in tracheal anastomosis and with a low incidence of hospital mortality (5%).


RESULTS
The actuarial patient survival is 90.2% (95% confidence interval, 70 to 97%) at 1 year and 75.7% (95% confidence interval, 51 to 90%) at 3 and 4 years. The mean forced expiratory volume in 1 second (FEV1) increases from 20.1% predicted preoperatively to 76.1%.


CONCLUSIONS
Despite the presence of airway pathogens, these results confirm that heart-lung transplantation for cystic fibrosis leads to a pronounced improvement in lung function and good rehabilitation after surgery. The two main obstacles are the shortage of donor organs and the possibility of late deterioration in lung function with a progressive airflow obstruction.
Haloun
A
A
Unité de transplantation thoracique, CHU de Nantes, France.
Despins
P
P
Horeau
D
D
Threilhaud
M
M
Portier
D
D
De Lajartre
A Y
AY
Jegou
B
B
Al Habach
O
O
Train
M
M
Duveau
D
D
Caillon
J
J
Michaud
J L
JL
D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000601:surgery*; D005260:Female; D005541:Forced Expiratory Volume; D016041:Heart-Lung Transplantation / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D009017:Morbidity; D011184:Postoperative Period
Transplantation cardiopulmonaire et mucoviscidose. Indications et résultats.