Novel versus conventional antipsychotic drugs.
Novel antipsychotic agents differ from conventional ones in several key characteristics, including effectiveness, adverse reactions, and receptor-binding profile. Most of the newer agents have an affinity for the serotonin 5HT2 receptor that is at least 10 times greater than that for the dopamine D2 receptor. This increased affinity for the serotonin receptor may be responsible for another distinguishing characteristic of novel antipsychotic agents--decreased frequency of extrapyramidal side effects. These side effects, which include pseudoparkinsonism, acute dystonias, and akathisia, frequently are the reason for noncompliance with conventional drug therapy. The newer drugs are often effective in patients resistant to treatment with conventional agents. They also appear to reduce the negative symptoms of schizophrenia in many patients.
Love
R C
RC
Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA.
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D018967:Risperidone / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D012702:Serotonin Antagonists; D003024:Clozapine; D018967:Risperidone