Synthesis and antimicrobial activity of new quaternary ammonium chlorides.
Decyldimethylamine reacts readily with chloromethylalkyl ethers of sulfides, chloromethylbenzyl ethers or sulfides and chloromethylcycloalkyl ethers to give quaternary ammonium chlorides in very good yields. All the chlorides studied showed antimicrobial activity. The relationship between the chemical structure and antimicrobial activity was analyzed by rough sets.
Brycki
B
B
Department of Chemistry, Adam Mickiewicz University, Poznań, Poland.
Skrzypczak
A
A
Mirska
I
I
Pernak
J
J
D001419:Bacteria / Q000187:drug effects; D004202:Disinfectants / Q000138:chemical synthesis* / Q000494:pharmacology; D004987:Ethers / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000378:metabolism
D004202:Disinfectants; D004987:Ethers; D000644:Quaternary Ammonium Compounds; D013440:Sulfides; C027118:didecyldimethylammonium