New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors.
Kim
C U
CU
Gilead Sciences Inc., Foster City, California 94404, USA.
McGee
L R
LR
Krawczyk
S H
SH
Harwood
E
E
Harada
Y
Y
Swaminathan
S
S
Bischofberger
N
N
Chen
M S
MS
Cherrington
J M
JM
Xiong
S F
SF
Griffin
L
L
Cundy
K C
KC
Lee
A
A
Yu
B
B
Gulnik
S
S
Erickson
J W
JW
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D008297:Male; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000494:pharmacology*
D017320:HIV Protease Inhibitors; D013450:Sulfones