Genetic differences between duodenal ulcer patients who were positive or negative for Helicobacter pylori.
This study investigated genetic differences between Helicobacter pylori-positive and -negative duodenal ulcer patients. Seventy-two patients with duodenal ulcer (61 H. pylori positive and 11 H. pylori negative) were examined for HLA-DQA1 genotype. The allele frequency of DQA1*0102 was higher in H. pylori-negative than in H. pylori-positive patients. Moreover, the genotypes that possessed the DQA1*0102 allele were significantly more common in H. pylori-negative than in H. pylori-positive patients. In contrast, the allele frequency of DQA1*0301 was lower in H. pylori-negative than H. pylori-positive patients. The genotypes that possessed DQA1*0301 were significantly more common in H. pylori-positive than in H. pylori-negative patients. These results suggest that there are genetic differences between H. pylori-positive and -negative duodenal ulcer patients and that immunogenetic factors for susceptibility or resistance to H. pylori infection exist in the host.
Azuma
T
T
Second Department of Internal Medicine, Fukui Medical School, Japan.
Konishi
J
J
Ito
Y
Y
Hirai
M
M
Tanaka
Y
Y
Ito
S
S
Kato
T
T
Kohli
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001706:Biopsy; D004381:Duodenal Ulcer / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D016145:Endoscopy, Digestive System; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics* / Q000276:immunology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen