On the parameters of the clonal expansion model.
The exact hazard function of the clonal expansion model was analyzed, and it was shown that only three of its four parameters can be determined by fitting to the age dependence of spontaneous tumor incidence rates. The same holds for the survival function.
Heidenreich
W F
WF
Institut für Strahlenschutz, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Oberschleissheim, Germany.
D017677:Age Distribution; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D006801:Humans; D015994:Incidence; D009154:Mutation; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D011336:Probability; D016016:Proportional Hazards Models; D013269:Stochastic Processes; D015996:Survival Rate