title: [The transformation of acute viral hepatitis B into chronic].
abstract: 500 patients with hepatitis B have been followed up from the acute onset to long-term outcome. As for chronic transformation of the disease, at higher risk are patients with mild form, progredient run and inadequate immune response. Of the highest value for identification and prognostication was a dynamic quantitative control over the system HBeAg-anti-HBe providing separate prognosis of establishment of replicative or integrative variants of chronic hepatitis B. In progredient infection an early administration of reaferon in combination with thymogen is thought valid which in many patients is sufficient to prevent the disease transformation into a chronic form.
authors.forename: S N
authors.initials: SN
authors.lastname: Sorinson
authors.forename: O V
authors.initials: OV
authors.lastname: Korochkina
authors.forename: A V
authors.initials: AV
authors.lastname: Frolov
authors.forename: O L
authors.initials: OL
authors.lastname: Shamshura
authors.forename: E A
authors.initials: EA
authors.lastname: Fomin
authors.forename: E E
authors.initials: EE
authors.lastname: Kuzovatova
authors.forename: M V
authors.initials: MV
authors.lastname: Neumoina
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Zhdanov
authors.forename: N I
authors.initials: NI
authors.lastname: Sivukhina
mesh_terms: D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D004151:Dipeptides; D018450:Disease Progression; D004359:Drug Therapy, Combination; D006509:Hepatitis B / Q000276:immunology* / Q000628:therapy; D006510:Hepatitis B Antibodies / Q000097:blood; D006511:Hepatitis B Antigens / Q000097:blood; D006521:Hepatitis, Chronic / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010455:Peptides / Q000627:therapeutic use; D011379:Prognosis; D011994:Recombinant Proteins; D012307:Risk Factors
chemical_list: D000276:Adjuvants, Immunologic; D015415:Biomarkers; D004151:Dipeptides; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010455:Peptides; D011994:Recombinant Proteins; C060736:thymogen
vernacular_title: Transformatsiia ostrogo virusnogo gepatita B v khronicheskiĭ.