The D2 dopamine receptor gene as a determinant of reward deficiency syndrome.
The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.
Blum
K
K
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284, USA.
Sheridan
P J
PJ
Wood
R C
RC
Braverman
E R
ER
Chen
T J
TJ
Cull
J G
JG
Comings
D E
DE
D003192:Compulsive Behavior / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000235:genetics*; D013577:Syndrome
D017448:Receptors, Dopamine D2