title: Propofol anaesthesia in spontaneously breathing paediatric patients during magnetic resonance imaging.
abstract: BACKGROUND
  The aim of this study was to evaluate the use of propofol to induce and maintain anaesthesia in spontaneously breathing paediatric patients (age 2 weeks-11 years) during Magnetic Resonance Imaging (MRI) of the CNS.
  
  
  METHODS
  All patients were spontaneously breathing, without intubation, and received supplemental O2. Pulse rate, blood pressure (BP), electrocardiogram and EtCO2 were recorded in all patients, and in 38 subjects SpO2 was also monitored. Patients were divided in 2 groups according to their body weights: Group A (n = 34, bwt < or = 10 kg), and Group B (n = 48, bwt > 10 kg).
  
  
  RESULTS
  Dosage of propofol during the time of induction (from insertion of the i.v. cannula to positioning on the MRI table) was significantly higher in smaller children (Group A; 5.4 +/- 2.2 (SD) mg/kg) as compared to children with bwt above 10 kg (Group B; 3.7 +/- 1.6 mg/kg). Propofol dosage for maintenance of anaesthesia was significantly higher in smaller children (Group A: 10.1 +/- 5.7 vs Group B: 7.1 +/- 3.0 mgkg-1 h-1, P = 0.003). During the time of induction, transient episodes of reduced BP (< or = 20%) occurred in 6 patients in Group A and 2 patients in Group B. During anaesthesia in Group B there was 1 episode of oxygen desaturation (95%), and 3 episodes of short and mild increases of EtCO2(< or = 52 mmHg). No other side effects occurred in any patient. MRI studies were successfully completed, only 3 sequences (Group A) had to be restarted.
  
  
  CONCLUSIONS
  Propofol can be safely used for total intravenous anaesthesia in children undergoing MRI.
authors.affiliation: Niguarda Ca' Granda Hospital, Neuroanesthesia Department, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Levati
authors.forename: N
authors.initials: N
authors.lastname: Colombo
authors.forename: E M
authors.initials: EM
authors.lastname: Arosio
authors.forename: G
authors.initials: G
authors.lastname: Savoia
authors.forename: C
authors.initials: C
authors.lastname: Tommasino
authors.forename: G
authors.initials: G
authors.lastname: Scialfa
authors.forename: L
authors.initials: L
authors.lastname: Boselli
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D015742:Propofol