Simple radioimmunological assay of anti-alpha-galactosyl antibody (anti-Gal): application to autoimmune thyroid diseases and thyroid-associated ophthalmopathy.
Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inhibiting immunoglobulins (TBII) and Thyroid Stimulating Antibodies (TSAb) are frequently found in serum of patients with Graves' disease but not with autoimmune thyroiditis. Although TBII and anti-Gal were found sometimes simultaneously in the same serum samples, we demonstrated that anti-Gal could be present in the absence of TBII and reciprocally.
Winand
R J
RJ
Thyroid Unit, CHU, Sart-Tilman, Belgium.
Winand-Devigne
J
J
Cox
C
C
Caulier
C
C
Meurisse
M
M
D000818:Animals; D001323:Autoantibodies / Q000097:blood* / Q000378:metabolism; D005128:Eye Diseases / Q000209:etiology / Q000276:immunology*; D006111:Graves Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood; D051379:Mice; D011863:Radioimmunoassay / Q000379:methods* / Q000706:statistics & numerical data; D011989:Receptors, Thyrotropin / Q000378:metabolism; D012680:Sensitivity and Specificity; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D014312:Trisaccharides / Q000276:immunology*
D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; D014312:Trisaccharides; C076569:alpha-galactosyl epitope; C094372:thyrotropin-binding inhibitory immunoglobulin