Two-locus approach of segregation and linkage analysis in the study of complex traits.
A two-locus segregation and linkage-analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two-locus Mendelian model fit the data significantly better than a one-locus model. The linkage results based on the most parsimonious two-locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one-locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two-locus models.
Xu
J
J
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Taylor
E W
EW
Panhuysen
C I
CI
Prenger
V L
VL
Koskela
R
R
Kiemeney
B
B
LaBuda
M C
MC
Maestri
N E
NE
Meyers
D A
DA
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D005069:Evaluation Studies as Topic; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D012044:Regression Analysis
D005819:Genetic Markers