[Activation of T-lymphocytes in Crohn disease and in ulcerative hemorrhagic rectocolitis. Therapeutic implications].
Inflammatory bowel disease (IBD) encompasses two forms of intestinal inflammation: ulcerative colitis and Crohn's disease. Besides abnormalities of immunoglobulins production and complement activation, T lymphocytes play an important role in pathogeny of these diseases. Although T-cells number is increased in intestinal mucosa of such patients, CD4/CD8 ratio of T lymphocytes subsets is normal in mucosa. Activated T-cells expressing interleukin-2 receptors (CD25) are increased in lamina propria from patients with IBD. Cytokines induce abnormal expression of class II antigens of major histocompatibility complex by epithelial cells which may act as antigen presenting cells to CD4 T-cells. Better understanding of pathogenic mechanisms in IBD might justify new immunosuppressive therapeutics to treat these patients.
Voiglio
E
E
INSERM U80, Hôpital E.-Herriot, Lyon, France.
Salle
B
B
Lemaitre
D
D
Cloix
P
P
Bancel
B
B
Cozon
G
G
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015704:CD4 Antigens / Q000276:immunology / Q000502:physiology*; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D003424:Crohn Disease / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D016207:Cytokines / Q000096:biosynthesis; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D016207:Cytokines
Activation des lymphocytes T dans la maladie de Crohn et dans la rectocolite ulcéro-hémorragique. Implications thérapeutiques.