Dietary wheat gluten alleviates the elevation of serum transaminase activities in D-galactosamine-injected rats.
The effects of dietary protein on the elevation of activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in D-galactosamine-injected rats were investigated. The rats fed with experimental diets containing test protein sources for 2 weeks were injected with D-galactosamine (0.8 g.kg-1 body weight). The activities of AST and ALT in serum were assayed after 20 h. According to the results, these enzyme activities in the rats fed 40% casein diet were higher than those of 5, 10, or 20% casein groups. In the 40% gluten group, these enzyme activities were lower than in the 40% casein group. This difference was not considered to be caused by the deficit of L-lysine and L-threonine in gluten. The extent of the reduction of UTP and UDP-glucose in liver by D-galactosamine was almost the same in the 40% gluten and 40% casein groups. These results suggest that levels and quality of dietary protein affect the susceptibility of animals to the hepatotoxin D-galactosamine and dietary gluten was found to alleviate the elevation of serum transaminases in rats by the drug.
Manabe
A
A
Division of Bioproduction Science, Faculty of Horticulture, Chiba University, Matsudo, Japan.
Cheng
C C
CC
Egashira
Y
Y
Ohta
T
T
Sanada
H
H
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D005688:Galactosamine / Q000008:administration & dosage*; D018698:Glutamic Acid / Q000494:pharmacology; D005983:Glutens / Q000008:administration & dosage / Q000494:pharmacology*; D007700:Kinetics; D008239:Lysine / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013912:Threonine / Q000494:pharmacology; D014908:Triticum; D014500:Uracil Nucleotides / Q000378:metabolism
D004044:Dietary Proteins; D014500:Uracil Nucleotides; D013912:Threonine; D018698:Glutamic Acid; D005688:Galactosamine; D005983:Glutens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008239:Lysine