Effect of aspirin treatment on plasma levels of keto PGF 1 alpha and thromboxane B2.
A study was carried out on the effect of aspirin 175 mg/day on the plasma levels of 6 keto PGF 1 alpha and TXB2 in patients with acute myocardial infarction and in patients subjected to coronary artery bypass surgery. Our results showed a fall in the levels of both the prostagladins from day one to day seven and further from seven to day nine in patients with myocardial infarction treated with aspirin 175 mg/day. In patients with myocardial infarction accompanied by arrhythmias the TXB2 levels dominated over the 6 Keto PGF 1 alpha levels. In the group of patients subjected to coronary bypass surgery but after treatment with aspirin 175 mg/day for a period of five days both 6 keto PGF 1 alpha and TXB2 levels fell significantly.
Madan
Z M
ZM
Division of Clinical and Experimental Research, Workhardt Ltd., Juslok Hospital and Research Centre.
Sainani
G S
GS
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000209:etiology; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D001026:Coronary Artery Bypass; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D011182:Postoperative Care; D013929:Thromboxane B2 / Q000097:blood*; D013997:Time Factors
D016861:Cyclooxygenase Inhibitors; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D001241:Aspirin