title: Pathophysiology of ion channel mutations.
abstract: The past year has seen significant advances in our understanding of ion channel disorders. The highlights of these advances include a detailed delineation of the molecular mechanisms underlying inherited cardiac arrhythmias and the discovery that ion channel mutations can contribute to neural development and neurodegeneration.
authors.affiliation: Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Keating
authors.forename: M C
authors.initials: MC
authors.lastname: Sanguinetti
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D004573:Electrolytes; D006706:Homeostasis; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000235:genetics*; D008024:Ligands; D009154:Mutation; D009410:Nerve Degeneration; D009474:Neurons; D014867:Water
chemical_list: D004573:Electrolytes; D007473:Ion Channels; D008024:Ligands; D014867:Water