title: Simultaneous quantitative evaluation of visual-evoked responses and background EEG activity in rat: normative data.
abstract: An integrated quantitative electroencephalography system (Phegra) for pharmacological and toxicological research in rat is described. Peak latencies and amplitudes of visual-evoked potentials, occurrence, duration, and linear excursions of photically evoked afterdischarges, "activity," "mobility," "complexity" of Hjorth, and absolute spectral powers of delta, theta, alpha, and beta frequency bands of background activity of visual cortex and frontal-visual leads were measured in freely moving rats. Counts of small and large movements were also registered. Data of baseline measurements performed in large amount of animals are presented. None of the parameters except the occurrence of photically evoked afterdischarge and the linear excursion of its averaged waveshape changed significantly in five measurements performed within six hours following the intraperitoneal and oral administration of two commonly used drug vehicles.
authors.affiliation: Pharmacological Research Centre, Chemical Works of G. Richter, Ltd., Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Sarkadi
authors.forename: Z
authors.initials: Z
authors.lastname: Inczeffy
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004569:Electroencephalography / Q000187:drug effects*; D005069:Evaluation Studies as Topic; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology*; D008297:Male; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D010600:Pharmacology / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D014116:Toxicology / Q000379:methods
chemical_list: D014677:Pharmaceutical Vehicles