title: Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.
abstract: PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
authors.affiliation: Infectious Disease Unit, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rusconi
authors.forename: M
authors.initials: M
authors.lastname: Moonis
authors.forename: D P
authors.initials: DP
authors.lastname: Merrill
authors.forename: P V
authors.initials: PV
authors.lastname: Pallai
authors.forename: E A
authors.initials: EA
authors.lastname: Neidhardt
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
authors.forename: K J
authors.initials: KJ
authors.lastname: Willis
authors.forename: M S
authors.initials: MS
authors.lastname: Osburne
authors.forename: A T
authors.initials: AT
authors.lastname: Profy
authors.forename: J C
authors.initials: JC
authors.lastname: Jenson
authors.forename: M S
authors.initials: MS
authors.lastname: Hirsch
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001667:Binding, Competitive; D015704:CD4 Antigens / Q000187:drug effects*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D002461:Cell Line, Transformed; D015699:HIV Envelope Protein gp120 / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008252:Macaca fascicularis; D009282:Naphthalenesulfonates / Q000494:pharmacology* / Q000633:toxicity; D011108:Polymers / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D009282:Naphthalenesulfonates; D011108:Polymers; D011994:Recombinant Proteins