title: Use of animals in the development and control of viral vaccines.
abstract: Animal models were central to the development of poliovaccines and remain essential in some form in the routine quality control of both live and killed vaccines. The necessity of an animal model is illustrated by the examples of mumps and measles vaccines where the existing materials, while satisfactory, have a number of drawbacks and where changes in current practice raise concerns for safety and efficacy.
authors.affiliation: National Institute of Biological Standards and Control, Potters Bar, Hertfordshire, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Minor
mesh_terms: D000826:Animal Testing Alternatives / Q000266:history; D000818:Animals; D049673:History, 20th Century; D006801:Humans; D008458:Measles Vaccine / Q000266:history; D009108:Mumps Vaccine / Q000266:history / Q000592:standards; D011054:Poliovirus Vaccine, Inactivated / Q000266:history / Q000592:standards; D011055:Poliovirus Vaccine, Oral / Q000266:history / Q000592:standards; D011786:Quality Control; D014481:United States; D014765:Viral Vaccines / Q000266:history* / Q000592:standards
chemical_list: D008458:Measles Vaccine; D009108:Mumps Vaccine; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D014765:Viral Vaccines