Decreased L-arginine-nitric oxide pathway in cultured myoblasts from spontaneously hypertensive versus normotensive Wistar-Kyoto rats.
The hypertrophy of the arterial media exhibited by spontaneously hypertensive rats is related to the hyperproliferation of their smooth muscle cells in culture. Using two methods to assay nitric oxide synthase activity, we showed that this abnormal proliferation results from a decreased activity of the inducible NOS II and less modulation of this enzymatic activity by these cells compared to control Wistar Kyoto cells.
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Pharmacologie des régulations cardiovasculaires, CNRS URA 1482, Faculte de Medecine Necker, Paris, France.
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D002956:Citrulline / Q000378:metabolism; D003470:Culture Media / Q000737:chemistry; D008938:Mitosis; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D017208:Rats, Wistar
D003470:Culture Media; D009573:Nitrites; D002956:Citrulline; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase