Biodegradable indium-111 labeled microspheres for in vivo evaluation of distribution and elimination.
Short-lived gamma emitting radioisotopes can be incorporated into polylactide/glycolide polymeric microspheres with various specific activities for possible use in understanding the in-vivo deposition, distribution and clearance of microparticulate drug carrier systems. The incorporated radiolabel is stable with negligible leaching out of the microspheres. These microspheres are suitable for studying the oral uptake of particles, lung distribution after inhalation delivery and evaluation of in-vivo fate following parenteral administration in systemic circulation or in specific tissue compartments.
Thanoo
B C
BC
College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
Doll
W J
WJ
Mehta
R C
RC
Digenis
G A
GA
DeLuca
P P
PP
D016503:Drug Delivery Systems; D007204:Indium / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011100:Polyglycolic Acid / Q000737:chemistry; D013997:Time Factors
D007204:Indium; D011100:Polyglycolic Acid