Pyralomicins, novel antibiotics from Microtetraspora spiralis. III. Biosynthesis of pyralomicin 1a.
The biosynthesis of pyralomicin 1a (1) was studied by feeding of 13C and 15N labeled compounds to the culture of Microtetraspora spiralis MI178-34F18. The result indicated that the benzopyranopyrrole unit of 1 was derived from two units of acetate, one unit of propionate and one unit of proline, and that the cyclitol unit of 1 was derived from glucose metabolites. And 4'-O-CH3 was derived from the S-CH3 group of methionine.
Kawamura
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Sawa
R
R
Takahashi
Y
Y
Sawa
T
T
Naganawa
H
H
Takeuchi
T
T
D000085:Acetates / Q000378:metabolism / Q000493:pharmacokinetics; D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001578:Benzopyrans / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D002867:Chromones / Q000378:metabolism; D005947:Glucose / Q000378:metabolism / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D011392:Proline / Q000378:metabolism / Q000493:pharmacokinetics; D011758:Pyrroles / Q000378:metabolism
D000085:Acetates; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D002867:Chromones; D011758:Pyrroles; C101442:pyralomicin 1a; D002244:Carbon; D011392:Proline; D005947:Glucose