Differentiation potential of rat amnion.
The differentiation potential of rat amnion was investigated by explantation to different extrauterine sites and by culturing in vitro. Amnion differentiated into full skin by a process that is morphologically indistinguishable from normal skin development (interactions of the surface embryonic ectoderm and underlying mesenchyme). This process is not dependent on the age of the amnion but is dependent on the culture conditions used. Possible implications of these findings are discussed.
Knezevic
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Institute of Biology, School of Medicine, University of Zagreb, Republic of Croatia.
D000650:Amnion / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D046508:Culture Techniques; D004475:Ectoderm / Q000166:cytology / Q000502:physiology; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D005260:Female; D008297:Male; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D009024:Morphogenesis / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena