title: Two-locus approach of segregation and linkage analysis in the study of complex traits.
abstract: A two-locus segregation and linkage-analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two-locus Mendelian model fit the data significantly better than a one-locus model. The linkage results based on the most parsimonious two-locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one-locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two-locus models.
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: E W
authors.initials: EW
authors.lastname: Taylor
authors.forename: C I
authors.initials: CI
authors.lastname: Panhuysen
authors.forename: V L
authors.initials: VL
authors.lastname: Prenger
authors.forename: R
authors.initials: R
authors.lastname: Koskela
authors.forename: B
authors.initials: B
authors.lastname: Kiemeney
authors.forename: M C
authors.initials: MC
authors.lastname: LaBuda
authors.forename: N E
authors.initials: NE
authors.lastname: Maestri
authors.forename: D A
authors.initials: DA
authors.lastname: Meyers
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D005069:Evaluation Studies as Topic; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D012044:Regression Analysis
chemical_list: D005819:Genetic Markers