HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors.
Cytogenetically visible aberrations of chromosomal region 12q14-15 in a variety of frequent benign human tumors reflect rearrangements of the HMGI-C gene. The mechanisms by which the HMGI-C gene contributes to tumorigenesis are mostly unknown, although frequently aberrant transcripts containing exons 1 to 3 of HMGI-C and ectopic sequences from other genes due to breaks within the third intron of HMGI-C are detectable. This is the first report analyzing human tissue samples mainly of mesenchymal origin by a highly sensitive polymerase-chain-reaction-based approach detecting HMGI-C expression. We found HMGI-C expression in embryonic tissue but no expression in any of several adult tissues tested except for two myometrial tissues. These data suggest that HMGI-C is mainly expressed in human tissues during embryonal and fetal development. Thus, its particular role for tumor development may be due to the expression of at least exons 1 to 3 rather than to the formation of fusion transcripts.
Rogalla
P
P
Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
Drechsler
K
K
Frey
G
G
Hennig
Y
Y
Helmke
B
B
Bonk
U
U
Bullerdiek
J
J
D000328:Adult; D000368:Aged; D001483:Base Sequence; D004622:Embryo, Mammalian / Q000737:chemistry; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006367:HeLa Cells / Q000502:physiology; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008648:Mesoderm / Q000737:chemistry*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009215:Myometrium / Q000737:chemistry; D009369:Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D012016:Reference Values; D012680:Sensitivity and Specificity; D014407:Tumor Cells, Cultured
D006609:High Mobility Group Proteins