title: [Heart-lung transplantation and cystic fibrosis. Indications and results].
abstract: BACKGROUND
  Heart lung transplantation for++ cystic fibrosis is now performed in patients with severe lung disease but the experience is still scarce with the exception of some specialized centers.
  
  
  METHODS
  Twenty-one patients underwent heart-lung transplantation between September 1989 and November 1994 in our institution, with a high standard of reliability in tracheal anastomosis and with a low incidence of hospital mortality (5%).
  
  
  RESULTS
  The actuarial patient survival is 90.2% (95% confidence interval, 70 to 97%) at 1 year and 75.7% (95% confidence interval, 51 to 90%) at 3 and 4 years. The mean forced expiratory volume in 1 second (FEV1) increases from 20.1% predicted preoperatively to 76.1%.
  
  
  CONCLUSIONS
  Despite the presence of airway pathogens, these results confirm that heart-lung transplantation for cystic fibrosis leads to a pronounced improvement in lung function and good rehabilitation after surgery. The two main obstacles are the shortage of donor organs and the possibility of late deterioration in lung function with a progressive airflow obstruction.
authors.affiliation: Unité de transplantation thoracique, CHU de Nantes, France.
authors.forename: A
authors.initials: A
authors.lastname: Haloun
authors.forename: P
authors.initials: P
authors.lastname: Despins
authors.forename: D
authors.initials: D
authors.lastname: Horeau
authors.forename: M
authors.initials: M
authors.lastname: Threilhaud
authors.forename: D
authors.initials: D
authors.lastname: Portier
authors.forename: A Y
authors.initials: AY
authors.lastname: De Lajartre
authors.forename: B
authors.initials: B
authors.lastname: Jegou
authors.forename: O
authors.initials: O
authors.lastname: Al Habach
authors.forename: M
authors.initials: M
authors.lastname: Train
authors.forename: D
authors.initials: D
authors.lastname: Duveau
authors.forename: J
authors.initials: J
authors.lastname: Caillon
authors.forename: J L
authors.initials: JL
authors.lastname: Michaud
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000601:surgery*; D005260:Female; D005541:Forced Expiratory Volume; D016041:Heart-Lung Transplantation / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D009017:Morbidity; D011184:Postoperative Period
vernacular_title: Transplantation cardiopulmonaire et mucoviscidose. Indications et résultats.