title: Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors.
abstract: A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Varnavas
authors.forename: L
authors.initials: L
authors.lastname: Lassiani
authors.forename: E
authors.initials: E
authors.lastname: Luxich
authors.forename: M
authors.initials: M
authors.lastname: Zacchigna
authors.forename: E
authors.initials: E
authors.lastname: Boccù
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D010179:Pancreas / Q000378:metabolism; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011799:Quinazolines; D011949:Receptors, Cholecystokinin