title: Soft tissue infections of the upper extremities with special consideration of abscesses in parenteral drug abusers. A prospective study.
abstract: Despite surgical advances and new antibiotics, upper extremity infections continue to present a serious problem. Soft tissue infections of the upper extremities were prospectively examined to elucidate incidence, cause, bacterial pathogens involved, and treatment. Special attention was paid to infections associated with parenteral drug abuse. During an 18-month period all patients over 16 years of age presenting for treatment of an established infection were included in the study. Conservative treatment consisted of immobilization and antibiotics. Radical débridement with removal of all necrotic tissue was the guideline for operative care. In addition, for both regimens a penicillinase-resistant antibiotic was administered. A total of 415 patients (271 men and 144 women; mean age 36.7 +/- 14.5 years) were enrolled into the study, 55 of whom were parenteral drug abusers; 45 of these were HIV-reactive. Infections of fingers (excluding paronychia), paronychia and abscesses at injection sites were the most common diagnoses. Operative and conservative treatment were performed in 285 and 130 patients respectively. Staphylococcus and streptococcus species were the predominant organisms recovered from 212 specimens of pus. Anaerobic bacteria and yeasts were of minor importance. Therefore, a penicillinase-resistant antibiotic is a good initial choice.
authors.affiliation: Department of Surgery, University of Zurich Medical School, Switzerland.
authors.forename: H P
authors.initials: HP
authors.lastname: Simmen
authors.forename: P
authors.initials: P
authors.lastname: Giovanoli
authors.forename: H
authors.initials: H
authors.lastname: Battaglia
authors.forename: J
authors.initials: J
authors.lastname: Wüst
authors.forename: V E
authors.initials: VE
authors.lastname: Meyer
mesh_terms: D000038:Abscess / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001132:Arm; D001424:Bacterial Infections / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D003131:Combined Modality Therapy; D003646:Debridement; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D018461:Soft Tissue Infections / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents