title: Suspected hypersensitivity pneumonitis after exposure to a biologic forage inoculant.
abstract: A 44-year-old farmer had respiratory symptoms and bibasilar pulmonary infiltrates after three exposures to a new biologic forage inoculant. Open lung biopsy revealed chronic interstitial pneumonitis and bronchiolitis obliterans with organizing pneumonia. The patient responded to oral corticosteroids but acutely worsened after an inadvertent reexposure to the forage inoculant. He later recovered, with return of lung function and chest radiograph toward normal. This case suggests that biologic forage inoculants may be associated with hypersensitivity pneumonitis.
authors.affiliation: Critical Care Medicine, West Virginia University School of Medicine, Morgantown, USA.
authors.forename: D
authors.initials: D
authors.lastname: Mannino
authors.forename: R
authors.initials: R
authors.lastname: Geiss
authors.forename: T
authors.initials: T
authors.lastname: Hodous
authors.forename: N L
authors.initials: NL
authors.lastname: Lapp
mesh_terms: D000328:Adult; D016573:Agrochemicals / Q000009:adverse effects*; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000473:pathology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001688:Biological Products / Q000009:adverse effects*; D001706:Biopsy; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000473:pathology; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology; D016273:Occupational Exposure; D011241:Prednisone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D016573:Agrochemicals; D000893:Anti-Inflammatory Agents; D001688:Biological Products; D005938:Glucocorticoids; D011241:Prednisone