title: [What can we think about diastolic hypertension?].
abstract: Isolated diastolic hypertension is not officially recognized as a form of hypertension. It is currently defined as a diastolic pressure greater than 90 mm Hg with systolic pressure < 140 mmHg. It implies an elevation of vascular resistance in the arteriolar sector and small arteries, and persistence of distensibility of the aorta and large vessels. It therefore predominantly affects young patients with relatively recent HT, without any accentuation of aging of the vessel wall by smoking, diabetes, or atheroma. It is responsible for a reduction of pulse pressure, and does not appear to be associated with deterioration of the prognosis. The demonstration of diastolic HT indicates the presence of excess adrenergic tone with predominance of alpha tone, or raised plasma renin, in the absence of any alteration of myocardial function capable of reducing systolic pressure. Monotherapy with angiotensin converting enzyme inhibitors, which reduce stimulation of growth of smooth muscle fibres, and calcium channel blockers, whose effects increase with increasing vasoconstrictor tone, would be preferable to diuretics and non-selective beta-blockers.
authors.affiliation: Service de Médecine Interne et Hypertension Artérielle, CHU Purpan, Toulouse.
authors.forename: M
authors.initials: M
authors.lastname: Salvador
authors.forename: J
authors.initials: J
authors.lastname: Amar
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D000317:Adrenergic alpha-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers
vernacular_title: Que penser de l'hypertension diastolique?