Propylthiouracil treatment reduces long-term potentiation in area CA1 of neonatal rat hippocampus.
Rat pups were made hypothyroid by exposure to propylthiouracil in drinking water beginning at 1 week of age, and the degree of long-term potentiation (LTP) in hippocampal area CA1 determined from brain slices of animals ranging in age from 2 to 6 weeks. Serum T3 levels were less than 20% of that of age matched controls after 3 weeks of treatment, and remained at that level. Relative to the age-matched controls, LTP was reduced significantly after 2 weeks of treatment. These observations are consistent with the conclusion that LTP magnitude is a reflection of cognitive function, which is known to be depressed in hypothyroid conditions in both animals and man.
Niemi
W D
WD
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201, USA.
Slivinski
K
K
Audi
J
J
Rej
R
R
Carpenter
D O
DO
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D013956:Antithyroid Agents / Q000494:pharmacology*; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000503:physiopathology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats
D013956:Antithyroid Agents; D011441:Propylthiouracil