Rat immunogenicity assay of inactivated poliovirus.
A rat immunogenicity assay for IPV potency was validated and applied to routine vaccine testing as a potential alternative to the CFR Monkey Potency Assay. Potencies of pure trivalent polio, various combinations and experimental vaccines were tested with a view of producing a single dilution assay.
Bevilacqua
J M
JM
Connaught Laboratories Limited, Willowdale, Ontario, Canada.
Young
L
L
Chiu
S W
SW
Sparkes
J D
JD
Kreeftenberg
J G
JG
D000826:Animal Testing Alternatives / Q000379:methods* / Q000592:standards; D000818:Animals; D008252:Macaca fascicularis; D011054:Poliovirus Vaccine, Inactivated / Q000032:analysis / Q000276:immunology* / Q000592:standards; D051381:Rats; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014481:United States; D015164:Vaccines, Inactivated / Q000032:analysis / Q000276:immunology / Q000592:standards
D011054:Poliovirus Vaccine, Inactivated; D015164:Vaccines, Inactivated