title: [Contraindications of thrombolytic therapy in acute myocardial infarct].
abstract: In 43 Swiss hospitals, 824 patients have been included in the ISIS-3 trial with suspected or proven myocardial infarction. Another 504 patients with proven myocardial infarction have been excluded for various reasons and have been registered in the study log-book (total 1328 patients). The usual clinical contraindications for thrombolysis are listed and discussed in this paper. 1/3 of those patients excluded from the trial had not received thrombolysis without clear contraindications (age, diabetes, anticoagulation, candidates for a pace-maker) and another 27% have had only relative contraindications (resuscitation, puncture, ulcer pain, hypertension). The new guidelines for thrombolytic therapy allowed more patients to benefit from this therapy.
authors.affiliation: Clinica Medica Ospedale Civico, Lugano, Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Genoni
authors.forename: R
authors.initials: R
authors.lastname: Malacrida
authors.forename: A
authors.initials: A
authors.lastname: Maggioni
authors.forename: T
authors.initials: T
authors.lastname: Moccetti
mesh_terms: D000328:Adult; D000368:Aged; D000075202:Contraindications; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D018579:Patient Selection; D011446:Prospective Studies; D012307:Risk Factors; D013557:Switzerland; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents
vernacular_title: Kontraindikationen der thrombolytischen Therapie beim akuten Myokardinfarkt.