title: Pyralomicins, novel antibiotics from Microtetraspora spiralis. III. Biosynthesis of pyralomicin 1a.
abstract: The biosynthesis of pyralomicin 1a (1) was studied by feeding of 13C and 15N labeled compounds to the culture of Microtetraspora spiralis MI178-34F18. The result indicated that the benzopyranopyrrole unit of 1 was derived from two units of acetate, one unit of propionate and one unit of proline, and that the cyclitol unit of 1 was derived from glucose metabolites. And 4'-O-CH3 was derived from the S-CH3 group of methionine.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kawamura
authors.forename: R
authors.initials: R
authors.lastname: Sawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000085:Acetates / Q000378:metabolism / Q000493:pharmacokinetics; D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001578:Benzopyrans / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D002867:Chromones / Q000378:metabolism; D005947:Glucose / Q000378:metabolism / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D011392:Proline / Q000378:metabolism / Q000493:pharmacokinetics; D011758:Pyrroles / Q000378:metabolism
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D002867:Chromones; D011758:Pyrroles; C101442:pyralomicin 1a; D002244:Carbon; D011392:Proline; D005947:Glucose