Deep brain stimulation for essential tremor.
We examined the effects and safety of deep brain stimulation (DBS) as a treatment for essential tremor (ET). Ten ET patients with disabling medication-refractory tremor underwent stereotactic implantation of a DBS lead in the left Vim thalamic nucleus and completed a 6-month follow-up. The Clinical Tremor Rating Scale and disability assessments were performed at baseline, 1-, 3-, and 6-month follow-up. There were significant improvements in dressing, drinking, eating, bathing, and handwriting as reported by the subjects. Tremor severity, writing, pouring, and spiral and line drawing were significantly improved as rated by the examiner. Improvements persisted through the 6-month follow-up period. Although global disability significantly lessened in the group as a whole, one subject with hand-finger tremor accentuated by writing had no change in disability status. In this 6-month open-label study, DBS was effective and safe in reducing tremor and functional disability in ET.
Hubble
J P
JP
Department of Neurology, University of Kansas Medical Center, Kansas City, USA.
Busenbark
K L
KL
Wilkinson
S
S
Penn
R D
RD
Lyons
K
K
Koller
W C
WC
D000368:Aged; D001921:Brain / Q000503:physiopathology*; D004185:Disability Evaluation; D004599:Electric Stimulation Therapy / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology; D019736:Prostheses and Implants; D012720:Severity of Illness Index; D013238:Stereotaxic Techniques; D013787:Thalamic Nuclei / Q000601:surgery; D016896:Treatment Outcome; D014202:Tremor / Q000503:physiopathology / Q000628:therapy*