The hairpin stack fold, a novel protein architecture for a new family of protein growth factors.
The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of beta-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.
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D000595:Amino Acid Sequence; D000818:Animals; D002347:Carps; D000077155:Granulins; D036341:Intercellular Signaling Peptides and Proteins; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
D000077155:Granulins; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins