title: Biologic effects of prolonged exposure to ELF electromagnetic fields in rats: II. 50 Hz magnetic fields.
abstract: To provide possible laboratory support to health risk evaluation associated with long-term, low-intensity magnetic field exposure, 256 male albino rats and an equal number of control animals (initial age 12 weeks) were exposed 22 h/day to a 50 Hz magnetic flux density of 5 microT for 32 weeks (a total of about 5000 h). Hematology was studied from blood samples before exposure to the field and at 12 week intervals. Morphology and histology of liver, heart, mesenteric lymph nodes, and testes as well as brain neurotransmitters were assessed at the end of the exposure period. In two identical sets of experiments, no significant differences in the investigated variables were found between exposed and sham-exposed animals. It is concluded that continuous exposure to a 50 Hz magnetic field of 5 microT from week 12 to week 44, which makes up approximately 70% of the life span of the rat before sacrifice, does not cause changes in growth rate, in the morphology and histology of liver, heart, mesenteric lymph nodes, testes, and bone marrow, in hematology and hematochemistry, or in the neurotransmitters dopamine and serotonin.
authors.affiliation: Department of Sciences and Biomedical Technologies, University of Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Margonato
authors.forename: P
authors.initials: P
authors.lastname: Nicolini
authors.forename: R
authors.initials: R
authors.lastname: Conti
authors.forename: L
authors.initials: L
authors.lastname: Zecca
authors.forename: A
authors.initials: A
authors.lastname: Veicsteinas
authors.forename: P
authors.initials: P
authors.lastname: Cerretelli
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight; D001853:Bone Marrow / Q000473:pathology; D001921:Brain / Q000378:metabolism; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006128:Growth; D008099:Liver / Q000473:pathology; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000473:pathology
chemical_list: D018377:Neurotransmitter Agents