Paraganglioma of the urinary bladder.
A paraganglioma of the urinary bladder in a 60-year-old woman presented with irritative voiding symptoms, without hematuria or hypertension. Sonography revealed a well-limited ovoid mass of the posterior wall, and cystoscopy showed that it was covered by normally appearing mucosa. Treatment consisted of transurethral resection, and the patient has been followed for 2 years without recurrence. Histologically the lesion consisted of small nests of spindle cells with clear to acidophilic cytoplasm; mitotic activity was inconspicuous. Immunohistochemical analyses revealed that the tumor cells were strongly positive for neuron-specific enolase and chromogranin A, and negative for cytokeratin, vimentin, neurofilaments, glial fibrillary acid protein and HMB 45. Sustentacular cells at the periphery of neoplastic cell clusters were positive for S-100 protein.
Nesi
G
G
Department of Pathology, University of Florence, Italy.
Vezzosi
V
V
Amorosi
A
A
Menghetti
I
I
Selli
C
C
D014408:Biomarkers, Tumor; D001706:Biopsy; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010235:Paraganglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D003598:Cytoskeletal Proteins; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase