Right-left asymmetry of D1- and D2-receptor density is lost in the basal ganglia of old rats.
In the present study a left-right asymmetry in both D1- and D2-receptor density in the caudate-putamen nucleus is shown and a lateralisation of D2-receptor distribution in the accunbens nucleus is also described. In old animals in which D1- and D2-receptors density is decreased, the dopamine receptor asymmetries are lost.
Giardino
L
L
Institute of Otorhinolaryngology II, University of Milano and Pathophysiology Center for the Nervous System, Hesperia Hospital, Modena, Italy.
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001345:Autoradiography; D001479:Basal Ganglia / Q000254:growth & development* / Q000378:metabolism* / Q000502:physiology; D001552:Benzazepines / Q000378:metabolism; D002421:Caudate Nucleus / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D018492:Dopamine Antagonists / Q000378:metabolism; D007839:Functional Laterality / Q000502:physiology*; D008297:Male; D009714:Nucleus Accumbens / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D011699:Putamen / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013469:Sulpiride / Q000378:metabolism
D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013469:Sulpiride