Microparticles of BSA substituted with deoxycholic acid and triethylene glycol glutarate. Correlations between the physico-chemical properties of the matrix and the release kinetics.
Bovine serum albumin or bovine serum albumin covalently linked to deoxycholic acid and triethylene glycol glutarate were used for the preparation of microspheres loaded with indomethacin. The presence of these residues on the bovine serum albumin molecule increased the loading levels. The kinetic analysis of release evidenced a zero order release period from the start of release in the microparticles obtained by bovine serum albumin linked to deoxycholic acid and triethylene glycol glutarate, followed by a decreasing rate release and a first Anomalous period followed by a zero order period in the albumin microparticles. These different release behaviours were correlated to the modifications induced by deoxycholic acid and triethylene glycol glutarate on the drug diffusivity and solubility in the matrix undergoing erosion.
Orienti
I
I
Università degli Studi di Bologna Dipartimento di Scienze Farmaceutiche, Italy.
Gianasi
E
E
Aiedeh
K
K
Zecchi
V
V
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003840:Deoxycholic Acid / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D007213:Indomethacin / Q000008:administration & dosage; D007700:Kinetics; D011092:Polyethylene Glycols / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
D005079:Excipients; D003840:Deoxycholic Acid; D012710:Serum Albumin, Bovine; C028914:triethylene glycol; D011092:Polyethylene Glycols; D007213:Indomethacin