title: Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease.
abstract: Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed.
authors.affiliation: Department of Genetics, Yale University, New Haven, Connecticut, USA.
authors.forename: L
authors.initials: L
authors.lastname: Almasy
authors.forename: C
authors.initials: C
authors.lastname: Tierney
authors.forename: N
authors.initials: N
authors.lastname: Risch
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D003198:Computer Simulation; D005260:Female; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008957:Models, Genetic; D015995:Prevalence; D018570:Risk Assessment
chemical_list: D005819:Genetic Markers