Sebaceous gland metaplasia in cardiac-type mucosa of the oesophago-gastric junction.
The first case of sebaceous gland metaplasia arising in cardiac-type mucosa of the oesophago-gastric junction of 71-year-old man is reported. Within cardiac glands, small nests composed of clear cells closely resembling sebaceous glands of the skin were found. Immunohistochemically, the cell nests stained positively for a monoclonal antibody 115D8 against milk-fat globule membrane (MAM-6). These cells were sometimes covered by cylindrical cells positive for foveolar-type mucin of the stomach (MI), and basal marginal cells of these nests expressed high molecular weight cytokeratins (34BE12). This study documents a new type of metaplasia of the gastric mucosa.
Kushima
R
R
Institute of Pathology, Heinrich Heine University, Düsseldorf, Germany.
von Hinüber
G
G
Lessel
W
W
Stolte
M
M
Borchard
F
F
D000368:Aged; D004943:Esophagogastric Junction / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008679:Metaplasia; D008970:Molecular Weight; D018396:Mucin-1 / Q000032:analysis; D009077:Mucins / Q000032:analysis; D012627:Sebaceous Glands / Q000473:pathology*
D018396:Mucin-1; D009077:Mucins; D007633:Keratins