Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups.
We report a cross-sectional study of 48 men, 56 premenopausal women, and 80 postmenopausal women who were of three ethnic/regional backgrounds: southern European (Greek, Italian), eastern European (Jewish, Polish, Hungarian), and western European (French, British). We determined bone mineral density (BMD) at four skeletal sites and assessed the vitamin D receptor (VDR) genotype by the Bsml restriction site polymorphism. Age and body mass index had significant effects on BMD by multiple regression analysis. In addition, ethnic/regional group had a significant effect on spinal BMD in premenopausal females (P = 0.014) and in males (P = 0.039). However, VDR genotype had no significant effect on BMD in any of the three study groups.
Spotila
L D
LD
Department of Biochemistry and Molecular Biology, Thomas Jefferson Medical College, Philadelphia, Pennsylvania.
Caminis
J
J
Johnston
R
R
Shimoya
K S
KS
O'Connor
M P
MP
Prockop
D J
DJ
Tenenhouse
A
A
Tenenhouse
H S
HS
D015519:Bone Density / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D017698:Postmenopause; D017697:Premenopause; D011792:Quebec / Q000208:ethnology; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol