title: Intact binocular function and absent ocular torsion in children with alternating skew on lateral gaze.
abstract: BACKGROUND
  A form of skew deviation, called alternating skew on lateral gaze, resembles bilateral superior oblique overaction. Oblique muscle overaction has been recently speculated to result from loss of fusion with subsequent "free-wheeling" of the torsional control mechanisms of the eyes, causing sensory intorsion or extorsion with attendant superior or inferior oblique muscle overaction, respectively. We wanted to investigate whether loss of fusion plays a role in the pathogenesis of alternating skew on lateral gaze.
  
  
  METHODS
  We examined seven consecutive patients with posterior fossa tumors, enrolled in a multi-disciplinary pediatric neuro-oncology program, who displayed alternating skew on lateral gaze. All patients underwent a thorough ophthalmologic evaluation.
  
  
  RESULTS
  Visual acuities in the study patients ranged from 20/20 to 20/40. Five of the seven patients were orthotropic, and showed 40 sec of arc stereopsis. Three patients showed associated downbeat nystagmus. No ocular torsion was found in any of the five patients who showed normal stereopsis upon inspection of fundus landmarks on indirect ophthalmoscopy.
  
  
  CONCLUSIONS
  Patients with alternating skew on lateral gaze often have normal binocular vision and stereopsis, and lack ocular intorsion so typical of superior oblique overaction. Alternating skew on lateral gaze is neurologically mediated, with no role for defective fusion in its pathogenesis.
authors.affiliation: Department of Ophthalmology, University of Florida College of Medicine, Gainesville 32610-0284, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Hamed
authors.forename: B L
authors.initials: BL
authors.lastname: Maria
authors.forename: S T
authors.initials: ST
authors.lastname: Briscoe
authors.forename: D
authors.initials: D
authors.lastname: Shamis
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications; D002648:Child; D003867:Depth Perception / Q000502:physiology; D005128:Eye Diseases; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D013285:Strabismus / Q000209:etiology / Q000503:physiopathology*; D014102:Torsion Abnormality; D015348:Vision, Binocular / Q000502:physiology*; D014792:Visual Acuity