A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat.
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides. It was shown that the oximes were potent antidotes in poisoning with phosphate insecticides. Obidoxime, pralidoxime and HI-6 had low effectiveness in the treatment of poisoning with phosphonates and phosphorothiolates. However, none of the oximes was an effective antidote in poisoning with dimethoate and pyridafenthion. Trimedoxime was the most effective oxime in the treatment of insecticide poisoning, being successful especially at the lowest tested doses.
Jokanović
M
M
Universita degli Studi di Padova, Istituto di Medicina del Lavoro, Italy.
Maksimović
M
M
D000284:Administration, Oral; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009768:Obidoxime Chloride / Q000627:therapeutic use; D009943:Organophosphorus Compounds; D010091:Oximes / Q000627:therapeutic use*; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014289:Trimedoxime / Q000627:therapeutic use
D000931:Antidotes; D007306:Insecticides; D009943:Organophosphorus Compounds; D010091:Oximes; D011220:Pralidoxime Compounds; D009768:Obidoxime Chloride; D014289:Trimedoxime; D001285:Atropine; C028797:pralidoxime; D003975:Diazepam