Optimizing sodium balance in hemodialysis.
this paper develops and tests a mathematical model for Na+ kinetics applied to standard hemodialysis. The volume of distribution of exchangeable Na+, dialyzer surface area, blood and dialysis fluid flow rate, target weight loss, treatment duration and the Na+ diffusibility constant are taken into account. The model is used to compute the optimal hour by hour dialysis fluid Na+ concentration required to achieve the prescribed end-dialysis natremia and maintain a constant end-dialysis body Na+ pool, while providing a nearly uniform removal of Na+ over dialysis. The model was preliminary tested on 10 consecutive dialyses in a single patient using special dialyzer which generates a part of ultrafiltrate uncontaminated by dialysate.
Sancipriano
G P
GP
Nephrology Service, USSL 27, Ciriè, Turin, Italy.
Negro
A
A
Amateis
C
C
Calitri
V
V
Cantone
F
F
Deabate
M C
MC
Della Casa
M
M
Fidelio
T
T
Iacono
G
G
Licata
C
C
Serra
A
A
Susa
I
I
D000368:Aged; D001835:Body Weight; D004058:Diffusion; D005260:Female; D015312:Hemodialysis Solutions / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008567:Membranes, Artificial; D008962:Models, Theoretical; D006435:Renal Dialysis / Q000295:instrumentation; D012964:Sodium / Q000097:blood* / Q000493:pharmacokinetics
D015312:Hemodialysis Solutions; D008567:Membranes, Artificial; D012964:Sodium