title: [The biochemical mechanism of cervical ripening after intracervical application of PGE2].
abstract: The influence of local intracervical application of PGE2 (Prostin E2-Upjohn) on collagenolytic activity as well as extracellular matrix components of human cervix during parturition has been analyzed. The content and extractability of collagen as well as concentration of glycosaminoglycans and hyaluronic acid were investigated. Since we did not find any statistical changes in DNP-peptide collagenolytic activity and investigated extracellular macromolecules of cervical connective tissue we presumed that cervical ripening after local prostaglandin application closely resembles that occurring spontaneously.
authors.affiliation: II Kliniki Ginekologii Operacyjnej AM w Lublinie.
authors.forename: T
authors.initials: T
authors.lastname: Rechberber
authors.forename: K
authors.initials: K
authors.lastname: Postawski
authors.forename: P
authors.initials: P
authors.lastname: Skorupski
authors.forename: J
authors.initials: J
authors.lastname: Czarnacki
authors.forename: J
authors.initials: J
authors.lastname: Jakowicki
mesh_terms: D003094:Collagen / Q000187:drug effects; D015232:Dinoprostone / Q000008:administration & dosage / Q000502:physiology*; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D007751:Labor, Induced; D007743:Labor, Obstetric / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy
chemical_list: D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D003094:Collagen; D015232:Dinoprostone
vernacular_title: Biochemiczny mechanizm procesu dojrzewania szyjki macicy ciezarnej po miejscowym zastosowaniu prostaglandyny E2.