title: [Neuropathologic data in drug-resistant partial epilepsy. Report of a series of 195 cases].
abstract: This report concerns the histopathological findings in 195 consecutive surgical specimens of patients with chronic drug-resistant epilepsy. Six pathological groups were identified corresponding to 63 tumors, 51 developmental lesions, 39 Ammon's horn sclerosis, 27 non specific changes, 11 glial or gliomesodermal scars and 4 Rasmussen's encephalitis. In 14 patients, 2 distinct abnormalities were observed with Ammon's horn sclerosis as one part of the dual pathology. All tumors were of low histopathological grade and included 30 dysembryoplastic neuroepithelial tumors, 17 gangliogliomas, 5 subependymal giant cell astrocytomas of tuberous sclerosis, 4 pleomorphic xanthoastrocytomas, 3 astroblastomas, 3 astrocytomas and 1 oligodendroglioma. Developmental lesions included 22 hamartomas, 12 focal dysplasias, 5 microdysgenesis, 1 nodular cortical heterotopia, 1 arachnoid cyst and 10 cavernomas. These findings emphasize two pathological features. Firstly, well-defined changes were present in all specimens. Secondly, the most common lesions were respectively tumors and developmental abnormalities.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Albert Michallon, CHU de Grenoble.
authors.forename: B
authors.initials: B
authors.lastname: Pasquier
authors.forename: F
authors.initials: F
authors.lastname: Bost
authors.forename: M
authors.initials: M
authors.lastname: Peoc'h
authors.forename: R
authors.initials: R
authors.lastname: Barnoud
authors.forename: D
authors.initials: D
authors.lastname: Pasquier
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D004660:Encephalitis / Q000473:pathology; D004828:Epilepsies, Partial / Q000473:pathology* / Q000601:surgery; D005260:Female; D006222:Hamartoma / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012598:Sclerosis
vernacular_title: Données neuropathologiques dans l'épilepsie partielle pharmacorésistante. Etude d'une série de 195 observations.