title: Sebaceous gland metaplasia in cardiac-type mucosa of the oesophago-gastric junction.
abstract: The first case of sebaceous gland metaplasia arising in cardiac-type mucosa of the oesophago-gastric junction of 71-year-old man is reported. Within cardiac glands, small nests composed of clear cells closely resembling sebaceous glands of the skin were found. Immunohistochemically, the cell nests stained positively for a monoclonal antibody 115D8 against milk-fat globule membrane (MAM-6). These cells were sometimes covered by cylindrical cells positive for foveolar-type mucin of the stomach (MI), and basal marginal cells of these nests expressed high molecular weight cytokeratins (34BE12). This study documents a new type of metaplasia of the gastric mucosa.
authors.affiliation: Institute of Pathology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Kushima
authors.forename: G
authors.initials: G
authors.lastname: von Hinüber
authors.forename: W
authors.initials: W
authors.lastname: Lessel
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: F
authors.initials: F
authors.lastname: Borchard
mesh_terms: D000368:Aged; D004943:Esophagogastric Junction / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008679:Metaplasia; D008970:Molecular Weight; D018396:Mucin-1 / Q000032:analysis; D009077:Mucins / Q000032:analysis; D012627:Sebaceous Glands / Q000473:pathology*
chemical_list: D018396:Mucin-1; D009077:Mucins; D007633:Keratins