title: An atypical recurrence of endometrial carcinoma following estrogen replacement therapy.
abstract: Following an abdominal hysterectomy and bilateral salpin-goophorectomy wherein a superficial (1.6 mm) well-differentiated endometrial cancer and bilateral ovarian serous cystadenomas were discovered, estrogen replacement was given. One year later the patient presented with a 9 x 7-cm left groin recurrence. Patients with endometrial carcinoma may request estrogen replacement. The benefits of such replacement are well recognized; however, these patients also need to be counselled that hormonal replacement may be complicated by recurrence. Physicians need to be cognizant of symptoms or signs which would suggest disease recurrence at unusual sites in these patients who are perceived as being at low risk for recurrent disease.
authors.affiliation: Department of Obsretrics and Gynecology, Indiana University School of Medicine, Indianapolis 46202-5274, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Carr
authors.forename: P A
authors.initials: PA
authors.lastname: Schoon
authors.forename: K Y
authors.initials: KY
authors.lastname: Look
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D018293:Cystadenoma, Serous / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology / Q000601:surgery*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D010051:Ovarian Neoplasms / Q000601:surgery