Case report: failure of adrenal scintigraphy to exhibit 131I cholesterol uptake in a CT-demonstrated, surgically proven aldosteronoma.
This is the case of a large 2 x 1.5 cm adrenal tumor demonstrated on CT scan that was proven biochemically and surgically to be an aldosteronoma and that did not concentrate 6-beta(131I)-iodo-methyl-19-norcholesterol (NP-59). Before the publication of this case, all CT-identified aldosteronomas of greater than 1 cm have concentrated NP-59. Previously, an adrenal mass of greater than 1 cm that failed to concentrate NP-59 was excluded from being an aldosteronoma. This concept must be reevaluated with the publication of this case.
Salam
Z
Z
Division of Endocrinology, Hahnemann University School of Medicine, Philadelphia, PA 19102, USA.
Lubbos
H
H
Martinez
C
C
Mozley
P D
PD
Miller
J L
JL
Rose
L I
LI
D015071:19-Iodocholesterol / Q000031:analogs & derivatives* / Q000378:metabolism; D000236:Adenoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
D015071:19-Iodocholesterol; C035501:6-iodomethylcholesterol