Metabolic changes in rats during a continuous infusion of recombinant interleukin-1.
The effects of recombinant interleukin-1 (IL-1), given as a continuous infusion for 6 days, on host responses were determined in rats. The development of fever, change in food intake and body weight, and key components of the acute-phase response in energy and protein metabolism were assessed. The effects of IL-1 were compared with those observed in a matched pair-fed group (semistarved), to distinguish the contribution from anorexia, and in a group that received IL-1 for 4 h acutely. IL-1 significantly increased core temperature, plasma levels of IL-6, and acute-phase protein production and decreased food intake and the circulating zinc level. The catabolic effects of IL-1 on nitrogen loss and muscle protein breakdown were independent of, and additive to those from malnutrition. The changes in energy expenditure, cumulative urinary nitrogen, and hydroxyproline excretion in the chronic IL-1 group were increased over semistarved animals. Finally, changes in muscle protein kinetics were only seen with chronic IL-1 infusion, and the changes in acute-phase protein were greater.
Ling
P R
PR
Laboratory of Nutrition/Infection, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
Schwartz
J H
JH
Jeevanandam
M
M
Gauldie
J
J
Bistrian
B R
BR
D000209:Acute-Phase Proteins / Q000378:metabolism; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005215:Fasting; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D008297:Male; D008762:Methylhistidines / Q000652:urine; D009584:Nitrogen / Q000652:urine; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins; D012016:Reference Values
D000209:Acute-Phase Proteins; D007375:Interleukin-1; D015850:Interleukin-6; D008762:Methylhistidines; D011506:Proteins; D011994:Recombinant Proteins; C028118:3-methylhistidine; D009584:Nitrogen; D006909:Hydroxyproline