Cloning and characterization of multiple opioid receptors.
Over the course of 1 to 2 years, the field has moved swiftly to investigate the functional and structural properties of the newly cloned opioid receptors. Achieving a better understanding of these macromolecules is likely to have profound implications for drug design aimed at the production of better analgesic drugs, for a more fundamental understanding of mechanisms of action of drugs of abuse, and for a more comprehensive knowledge base regarding the biology of opioid peptides in particular, and neuroactive peptides in general.
Akil
H
H
Mental Health Research Institute, University of Michigan, Ann Arbor 48109-0720, USA.
Meng
F
F
Mansour
A
A
Thompson
R
R
Xie
G X
GX
Watson
S
S
D000818:Animals; D003001:Cloning, Molecular; D006801:Humans; D008024:Ligands; D010455:Peptides / Q000378:metabolism; D017465:Receptors, Opioid, delta / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017473:Receptors, Opioid, kappa / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000502:physiology; D013329:Structure-Activity Relationship
D008024:Ligands; D010455:Peptides; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D011993:Recombinant Fusion Proteins