HLA class I and II polymorphisms and trachomatous scarring in a Chlamydia trachomatis-endemic population.
Immune responses to Chlamydia trachomatis contribute to protection from infection and to immunopathologic disease. To test whether subjects' HLA class I (A, B, and Cw) or class II (DRbeta1 and DQbeta1) types influence risk of trachomatous scarring from chronic infection with C trachomatis, 153 cases and pair-matched controls in Gambia were studied. No HLA type was associated with protection from scarring, indicating that protective immune responses are not limited to only one or a few HLA-restricted epitopes in C. trachomatis antigens. One class I antigen, HLA-A28, was significantly more common among cases than controls (25.8% vs. 15.9%, respectively; McNemar's odds ratio [OR], 1.88; 95% confidence interval [CI] = 1.01-3.49; P = .046). In DNA subtyping of the A28 specificity, the A*6801 allele was equally common among cases and controls, but the A*6802 allele was significantly overrepresented among cases (McNemar's OR, 3.14; 95% CI = 1.32-7.44; P = .009). This association may be due to an immunopathologic HLA-A*6802-restricted cytotoxic T lymphocyte response.
Conway
D J
DJ
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, UK.
Holland
M J
MJ
Campbell
A E
AE
Bailey
R L
RL
Krausa
P
P
Peeling
R W
RW
Whittle
H C
HC
Mabey
D C
DC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D000907:Antibodies, Bacterial / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002692:Chlamydia trachomatis / Q000276:immunology; D002908:Chronic Disease; D002921:Cicatrix / Q000235:genetics* / Q000276:immunology*; D005143:Eyelids / Q000473:pathology*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014141:Trachoma / Q000235:genetics* / Q000276:immunology*; D014774:Virulence
D000907:Antibodies, Bacterial; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G