title: Ischemic preconditioning--a new concept in orthopedic and reconstructive surgery.
abstract: The duration of tourniquet-induced ischemia during orthopedic and reconstructive surgery is limited by the risk of ischemia and reperfusion injury to skeletal muscle. This study evaluated the potential of ischemic preconditioning (short periods of ischemia with intermittent reperfusion) to improve skeletal muscle function after ischemia and reperfusion in a rodent model. Preconditioning was found to improve force, contractility, and performance and to decrease fatigue of skeletal muscle. In contrast, energy-rich phosphates, measured concurrently, were not affected by preconditioning, suggesting mechanisms other than energy preservation to be involved. In summary, preconditioning may enable prolongation of orthopedic and reconstructive procedures.
authors.affiliation: Department of Surgical Research, University of Basel, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Gürke
authors.forename: A
authors.initials: A
authors.lastname: Marx
authors.forename: P M
authors.initials: PM
authors.lastname: Sutter
authors.forename: A
authors.initials: A
authors.lastname: Frentzel
authors.forename: F
authors.initials: F
authors.lastname: Harder
authors.forename: J
authors.initials: J
authors.lastname: Seelig
authors.forename: M
authors.initials: M
authors.lastname: Heberer
mesh_terms: D000818:Animals; D001831:Body Temperature; D004734:Energy Metabolism; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009132:Muscles / Q000098:blood supply* / Q000503:physiopathology; D009985:Orthopedics / Q000379:methods*; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion; D014111:Tourniquets
chemical_list: D010710:Phosphates