title: Histopathologic features in esophagomyotomy specimens from patients with achalasia.
abstract: OBJECTIVE
  A previous study evaluating the morphological features of esophagi resected for endstage achalasia showed marked depletion of myenteric ganglion cells, widespread destruction of nerves, and variable chronic inflammation. The aim of this study was to evaluate the histological features in esophagomyotomy specimens from 11 patients with early achalasia, defined as minimal to moderate esophageal dilation without sigmoid deformity.
  
  
  METHODS
  The histological features of esophagomyotomy specimens from 11 patients with achalasia were analyzed and compared with the findings of control specimens obtained from 8 patients who underwent esophagectomy for intramucosal adenocarcinoma.
  
  
  RESULTS
  Control specimens had normal numbers of ganglion cells (0.70-0.91 ganglion cells per high-power field) and minimal inflammation. Three patients with vigorous achalasia had normal ganglion cell numbers (0.79-0.91 ganglion cells per high-power field) and at least mild myenteric inflammation without neural fibrosis. The remaining 8 patients had few or no ganglion cells (0-0.30 ganglion cells per high-power field) and at least mild myenteric inflammation and neural fibrosis. Ganglionitis was found in 2 cases. Ganglion cell number was inversely correlated with degree of myenteric neural fibrosis (P < 0.001).
  
  
  CONCLUSIONS
  Vigorous achalasia has pathological features that are distinct from classic achalasia. The earliest pathological changes consist of myenteric inflammation with injury to and subsequent loss of ganglion cells and injury to and fibrosis of myenteric nerves.
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Goldblum
authors.forename: T W
authors.initials: TW
authors.lastname: Rice
authors.forename: J E
authors.initials: JE
authors.lastname: Richter
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D004931:Esophageal Achalasia / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005724:Ganglia / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology* / Q000601:surgery*; D009197:Myenteric Plexus / Q000473:pathology; D011312:Pressure