3-Deoxyglucosone reductase in dog adrenal glands. Identification as aldose reductase.
3-Deoxyglucosone is one of the major cytotoxic intermediates in the Maillard reaction. Adrenal glands showed the highest NADPH-linked 3-deoxyglucosone reductase activity of dog tissues. The enzyme was purified to homogeneity from the adrenal glands, and demonstrated to be structurally, functionally and immunologically identical with aldose reductase, which comprises about 6% of the soluble adrenal proteins.
Matsuura
K
K
Biochemistry Laboratory, Gifu Pharmaceutical University, Japan.
Sato
K
K
Deyashiki
Y
Y
Nakanishi
M
M
Hara
A
A
D000311:Adrenal Glands / Q000201:enzymology*; D000429:Alcohol Oxidoreductases / Q000737:chemistry / Q000302:isolation & purification*; D000449:Aldehyde Reductase / Q000737:chemistry / Q000302:isolation & purification*; D000595:Amino Acid Sequence; D000818:Animals; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000378:metabolism; D004285:Dogs; D008297:Male; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
D003847:Deoxyglucose; D000429:Alcohol Oxidoreductases; C019642:alcohol dehydrogenase (NADP+); D000449:Aldehyde Reductase; C016350:3-deoxyglucosone