title: Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia.
abstract: We report a 47-year-old Japanese woman with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) combined with acute type adult T-cell leukemia (ATL). The susceptibility for HAM/TSP and acute type of ATL is hitherto explained by human leukocyte antigen (HLA) haplotype-linked immune responsiveness to HTLV-I. This patient's HLA (A24Cw1B54DR4DQ4/A24Cw3B51DR8DQ1) included a HAM-associated HLA haplotype. This suggests that HAM patients with HAM-associated HLA haplotype can also develop the acute type of ATL.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University.
authors.forename: Y
authors.initials: Y
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Okadome
authors.forename: M
authors.initials: M
authors.lastname: Tara
authors.forename: K
authors.initials: K
authors.lastname: Niina
authors.forename: S
authors.initials: S
authors.lastname: Izumo
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D015493:Paraparesis, Tropical Spastic / Q000150:complications* / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D006680:HLA Antigens