The effects of L-deprenyl on spatial short term memory in young and aged dogs.
1. Young and aged dogs were tested on a spatial memory task using a delayed non matching to sample technique. Dogs were tested with 20, 70 and 110 second delay intervals. Animals were pretrained to a stable level of performance prior to treatment. 2. During treatment periods, dogs were orally administered a placebo or I-deprenyl in doses of 0.5 and 1.0 mg/kg in a repeated measures design. 3. Young dogs did not show any significant effects of I-deprenyl, however the sample size was limited. 4. L-deprenyl administration improved spatial memory in aged dogs. 5. The optimal dose or length of treatment time of I-deprenyl varied among individual dogs.
Head
E
E
University of Toronto, Division of Life Sciences, Scarborough, Ontario, Canada.
Hartley
J
J
Kameka
A M
AM
Mehta
R
R
Ivy
G O
GO
Ruehl
W W
WW
Milgram
N W
NW
D000375:Aging / Q000187:drug effects*; D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D012642:Selegiline / Q000494:pharmacology*; D013997:Time Factors
D012642:Selegiline