Intraventricular glucose blocks feeding induced by 2-deoxy-D-glucose but not mercaptoacetate.
Previous results have shown that IV infusion of glucose reduces feeding induced by systemic administration of 2-deoxy-D-glucose (2-DG) or 2-mercaptoacetate (MA) in rats. Because glucose is a metabolic substrate for both central and peripheral tissues, the suppression of feeding by glucose could result from either a central or peripheral metabolic effect. In the present experiment we attempted to clarify the mechanism of glucose-induced suppression of feeding induced by 2-DG and MA by administering glucose centrally during systemic metabolic challenge. Administration of glucose into the lateral ventricle was begun immediately after systemic injection of 2-DG or MA and continued intermittently during the 2-h feeding test. We found that central glucose administration significantly reduced 2-DG- but not MA-induced feeding. These results suggest that the central effects of glucose are sufficient to suppress feeding induced by systemic 2-DG and support the hypothesis that receptors responsible for 2-DG-induced feeding are located in the brain.
Singer
L K
LK
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520s, USA.
Ritter
S
S
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013864:Thioglycolates / Q000494:pharmacology*
D000963:Antimetabolites; D013864:Thioglycolates; C017487:2-mercaptoacetate; D003847:Deoxyglucose; D005947:Glucose