Beta activity in aging and dementia.
Considerable variation remains in the reported effects of disease, age and gender on high frequency electroencephalographic activity. We examined the topographic differences in relative and absolute beta power in the 14-54 Hz range in 49 subjects with dementia of the Alzheimer's type (DAT), 25 subjects with multi-infarct dementia (MID), and 62 normal control subjects (CON). Associations of these spectral parameters with age, gender and cognitive status were assessed. Normal control subjects showed modest positive correlations in frontal, central and parietal regions across the age range of 24-90 years but not across a narrower 60-90 year range. Women, particularly women over 60 years of age, showed increased relative and absolute beta power compared to men. Subjects with dementia showed global decreases particularly in relative power. Decreases were most prominent in central and parietal regions for DAT subjects, with MID subjects additionally showing prominent frontal decreases. DAT and MID subjects differed in their correlations of power with age, Folstein Mini Mental State Exam (MMSE) and gender across frontal, central, parietal and temporal regions. Differences in the regional attenuation of absolute and relative beta power within specific high frequency bands may reflect the disparate neuropathologic processes of DAT and MID, as well as the extent of brain dysfunction and the effects of gender.
Holschneider
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Quantitative EEG Laboratory, UCLA Neuropsychiatric Institute and Hospital 90024, USA.
Leuchter
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AF
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001611:Beta Rhythm; D001921:Brain / Q000503:physiopathology; D003704:Dementia / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged