The mechanistic rationale in support of dietary cancer prevention.
Mechanistic studies are an essential component of dietary cancer prevention trials. In breast and prostate cancer, a low-fat diet with a reduction in omega-6 fatty acid may prove effective, not only because of related decreases in sex steroid hormones, but as a result of altered eicosanoid biosynthesis. An optimal approach to primary and secondary prevention is likely to be a dietary change combined with one or more pharmacologically based chemopreventive agents. Patients with in situ carcinoma of the breast or prostate are candidates for dietary intervention as a means of secondary prevention.
Rose
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DP
Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York 10595, USA.
D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control; D003043:Cocarcinogenesis; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000009:adverse effects; D015777:Eicosanoids / Q000096:biosynthesis; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control*; D011471:Prostatic Neoplasms / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors
D004041:Dietary Fats; D015777:Eicosanoids; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated