title: QTc prolongation indicates a poor prognosis in patients with organophosphate poisoning.
abstract: This study reviewed emergency department electrocardiograms of 223 patients with organophosphate poisoning from January 1982 to June 1994: 97 (43.5%) had QTc prolongation and were placed in group A; 126 patients without QTc prolongation were designated as group B. Compared with group B, group A patients had a higher mortality (19.6% v 4.8%, P < .001) and a higher incidence of respiratory failure (56.7% v 20.6%, P < .001). Serum cholinesterase levels were determined in the 223 patients: 92 (41.3%) were classified as severe poisoning. 32 (14.3%) as moderate, 41 (18.1%) as mild, and 58 (25.7%) as very mild. The severe group had a high incidence of QTc prolongation (P < .001), a high incidence of respiratory failure (P < 0.001), and a higher mortality rate (P < 0.001) than the other groups. Of the QTc prolongation patients, 59.8% (55/92) had a high incidence of respiratory failure (78.2% v 35.1%, P < .0001) and a higher mortality rate (29.1% v 8.1%, P < 0.05) compared with 40.2% (37/92) of the patients without QTc prolongation in the severe group. In conclusion, a complete electrocardiogram at the emergency department is important and of prognostic value.
authors.affiliation: Poison Center, Chang-Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C.
authors.forename: F R
authors.initials: FR
authors.lastname: Chuang
authors.forename: S W
authors.initials: SW
authors.lastname: Jang
authors.forename: J L
authors.initials: JL
authors.lastname: Lin
authors.forename: M S
authors.initials: MS
authors.lastname: Chern
authors.forename: J B
authors.initials: JB
authors.lastname: Chen
authors.forename: K T
authors.initials: KT
authors.lastname: Hsu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002802:Cholinesterases / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D011041:Poisoning / Q000097:blood / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012189:Retrospective Studies
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; D002802:Cholinesterases