title: Excretion of ciprofloxacin into the large bowel of the rabbit.
abstract: The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral dose of 27 mg of ciprofloxacin per kg of body weight. The elimination rates of ciprofloxacin were 0.126 +/- 0.084 micrograms.min-1.cm-2 in the cecum and 0.264 +/- 0.126, 0.11 +/- 0.07, and 0.21 +/- 0.141 micrograms.min-1.cm-2 in the proximal colon, distal colon, and sigmoid colon, respectively. The calculated fraction of ciprofloxacin eliminated in the large bowel was 3% of the parenteral dose administered. The elimination pattern of ciprofloxacin in the large bowel may explain the unusual activity of this fluoroquinolone in modifying the colonic flora.
authors.affiliation: Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Ramon
authors.forename: S
authors.initials: S
authors.lastname: Dautrey
authors.forename: R
authors.initials: R
authors.lastname: Farinoti
authors.forename: C
authors.initials: C
authors.lastname: Carbon
authors.forename: E
authors.initials: E
authors.lastname: Rubinstein
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001692:Biological Transport; D002432:Cecum / Q000378:metabolism; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012809:Colon, Sigmoid / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D007420:Intestine, Large / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D011817:Rabbits
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin