title: A comparison of the effects of food deprivation and 2,5-anhydro-D-mannitol on metabolism and ingestion.
abstract: Using respiratory quotient as an index of metabolic state, we compared the effects of administrations of the fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) at a dose of 300 mg/kg with the effect of 10 h of food deprivation. We measured behavioral and physiological responses of the animals receiving the two treatments, including food intake, energy expenditure, rates of carbohydrate and fatty acid utilization, and plasma levels of glucose, insulin, corticosterone, epinephrine, and norepinephrine. A vehicle-treated control group was also included. Fasting produced a greater food intake than 2,5-AM administration. Although plasma glucose, insulin, and norepinephrine levels were similar between the two treatments, plasma corticosterone and epinephrine levels were significantly elevated in animals receiving 2,5-AM. We conclude that although 2,5-AM can produce a metabolic state similar to fasting, as measured by an index of whole body metabolic state (respiratory quotient), there remain factors that influence food intake that are not similar in the two conditions.
authors.affiliation: Behavioral Neuroscience Interdisciplinary Group, University of Washington, Seattle 98195, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Park
authors.forename: L
authors.initials: L
authors.lastname: Benthem
authors.forename: R J
authors.initials: RJ
authors.lastname: Seeley
authors.forename: M I
authors.initials: MI
authors.lastname: Friedman
authors.forename: C W
authors.initials: CW
authors.lastname: Wilkinson
authors.forename: S C
authors.initials: SC
authors.lastname: Woods
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation / Q000502:physiology*; D006728:Hormones / Q000097:blood; D008297:Male; D008353:Mannitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008660:Metabolism / Q000187:drug effects*; D051381:Rats; D012119:Respiration / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D006728:Hormones; D008353:Mannitol; C031765:2,5-anhydromannitol