Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c.
The sites of accumulation and growth of antigen-specific T cells was assessed during the V alpha 11/V beta 3 T cell receptor-restricted response of IEk+ mice to pigeon cytochrome c. In the T zone, the response was early but transient; V alpha 11/V beta 3+ T cell numbers fell to background levels as germinal centers developed. The follicles were a major site of specific T cell growth, but V alpha 11/V beta 3+ T cells were not obvious in foci of extrafollicular B cell growth in the red pulp. As germinal centers waned, V alpha 11/V beta 3+ T cells in the T zones again rose above background levels and some persisted in the follicles. After the initial stage of T cell priming, specific T cell growth seems to occur where specific interaction can occur with B cells that are presenting processed antigen.
Gulbranson-Judge
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Department of Immunology, University of Birmingham Medical School, GB.
MacLennan
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D000818:Animals; D002455:Cell Division / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D002645:Chickens; D010856:Columbidae; D003574:Cytochrome c Group / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D005260:Female; D007114:Immunization; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D013154:Spleen / Q000033:anatomy & histology / Q000166:cytology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D003574:Cytochrome c Group; D000939:Epitopes; D016693:Receptors, Antigen, T-Cell, alpha-beta; D005719:gamma-Globulins