title: The action of ginsenoside Re on inotropy and chronotropy of isolated atria prepared from guinea pigs.
abstract: The effects of ginsenoside Re on atria properties of guinea pigs were studied in vitro. Re decreased dose-dependently the contractile force and frequency of isolated guinea pig atria. The correlation of dose-effects of Re on autorhythmicity and contractility of atria was significant. 4.7 x 10(-8) M Re prolonged the effective refractory period (ERP) of the left atria. Re noncompetitively antagonized the positive chronotropic action of isoprenaline in isolated right atria, PD'2 = 6.37. Re and verapamil non-competitively antagonized the positive inotropic action of CaCl2; the PD'2 value of Re is 6.55; of the PD'2 value of Ver is 5.60.
authors.affiliation: Department of Pharmacology, Hunan Medical University, Changsha, Peoples Republic of China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Jin
mesh_terms: D000818:Animals; D036145:Ginsenosides; D006168:Guinea Pigs; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D005894:Panax; D010946:Plants, Medicinal; D012503:Saponins / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
chemical_list: D036145:Ginsenosides; D012503:Saponins; C049864:ginsenoside Re; D014700:Verapamil