Depression as a dynamical disease.
Mathematical models are helpful in the understanding of diseases through the use of dynamical indicators. A previous study has shown that brain activity can be characterized by a decrease of dynamical complexity in depressive subjects. The present paper confirms and extends these conclusions through the use of recent methodological advances: first episode and recurrent patients strongly differ in their dynamical response to therapeutic interventions. These results emphasize the need for clinical follow-ups to avoid recurrence and the necessity of specific therapeutic intervention in the case of recurrent patients.
Pezard
L
L
Unité de Psychophysiologie Cognitive, LENA (CNRS URA 654-UPMC), Paris, France.
Nandrino
J L
JL
Renault
B
B
el Massioui
F
F
Allilaire
J F
JF
Müller
J
J
Varela
F
F
Martinerie
J
J
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D002997:Clomipramine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010555:Personality Inventory; D012008:Recurrence; D012815:Signal Processing, Computer-Assisted
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine; D002997:Clomipramine