Ligand-gated calcium channels inside and out.
Calcium release from intracellular stores occurs through two types of channels associated with intracellular membranes, namely, the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor. Recently, it has been shown that these channels are regulated by allosteric mechanisms and associated proteins. Release of intracellular calcium induces the opening of calcium-permeable channels on the plasma membrane. Current work has focused on the molecular and functional characterization of these channels which have been identified as store-operated channels or calcium release activated channels.
Striggow
F
F
Department of Physiology, Universityof Connecticut, 263 Farmington Avenue, Farmington, CT 06030-3505, USA.
Ehrlich
B E
BE
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D002352:Carrier Proteins; D002462:Cell Membrane / Q000378:metabolism; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007425:Intracellular Membranes / Q000378:metabolism; D015640:Ion Channel Gating; D008024:Ligands; D008954:Models, Biological; D011487:Protein Conformation; D022021:Tacrolimus Binding Proteins
D015220:Calcium Channels; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D008024:Ligands; D022021:Tacrolimus Binding Proteins; D002118:Calcium