Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii.
Keenamide A (1), a new cytotoxic cyclic hexapeptide, was isolated from the notaspidean mollusk Pleurobranchus forskalii. Its structure was determined by NMR spectral data interpretation and chiral amino acid analysis. Keenamide A (1) exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.
Wesson
K J
KJ
Department of Pharmacognosy, University of Mississippi 38677, USA.
Hamann
M T
MT
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008974:Mollusca / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000962:Antimalarials; D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C100907:keenamide A