title: Betahistine-induced bronchospasm.
abstract: Betahistine is a cerebral vasodilator structurally related to histamine, which stimulates H1 bronchial and vascular receptors. We report the case of a 28-year-old female patient who presented bronchospasm during treatment with betahistine hydrochloride. The prick test was negative. The oral challenge test showed bronchospasm and urticarial lesions. To the best of our knowledge, this is the first case of betahistine-induced bronchospasm reported in the literature. The study carried out failed to reveal the mechanism of the reaction.
authors.affiliation: Department of Allergology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Jiménez
authors.forename: E
authors.initials: E
authors.lastname: Antón
authors.forename: I
authors.initials: I
authors.lastname: Picáns
authors.forename: J
authors.initials: J
authors.lastname: Jerez
mesh_terms: D000328:Adult; D001621:Betahistine / Q000009:adverse effects*; D001986:Bronchial Spasm / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D012882:Skin Tests; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D007073:Immunoglobulin E; D001621:Betahistine