Ervatamia coronaria: chemical constituents and some pharmacological activities.
A new bisindole alkaloid, 19,20-dihydroervahanine A was isolated from the stems of Ervatamia coronaria grown in Brazil, together with five known alkaloids: coronaridine, heyneanine, voacristine, voacamine, descarbomethoxyvoacamine and five phenolic acids: vanillic, gentisic, syringic, 4-hydroxybenzoic and salicylic acid. The aqueous and alcoholic extracts, when administered p.o. or i.p. to rats 1 h before subplantar injection of carrageenin had a significant anti-inflammatory effect. The alcoholic extract also had an analgesic effect and increased the pentobarbital induced sleeping time.
Henriques
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AT
Faculty of Pharmacy, UFRGS, Porto Alegre, RS, Brazil.
Melo
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AA
Moreno
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PR
Ene
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LL
Henriques
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JA
Schapoval
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EE
D000470:Alkaloids / Q000032:analysis / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001938:Brazil; D007211:Indoles / Q000032:analysis / Q000494:pharmacology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
D000470:Alkaloids; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D007211:Indoles; D010936:Plant Extracts