title: Preliminary observations on possible premalignant changes in bone marrow adjacent to worn total hip arthroplasty implants.
abstract: Previous epidemiologic studies have suggested that there may be a risk of malignancy, especially lymphoma and leukemia, after joint replacement, but the followup has been relatively short. This is a preliminary study to see if there is any biologic basis for such a risk. Blood and bone marrow samples from 71 patients at revision arthroplasty of a loose or worn prosthesis and 30 control patients at primary arthroplasty were analyzed with cytogenetic techniques and molecular biology. There was a higher chromosomal aberration rate in cells adjacent to the prosthesis at revision surgery compared with iliac crest marrow from the same patients or with femoral bone marrow at primary arthroplasty. Clonal expansion of lymphocytes without a serum paraprotein was seen in 2 of 21 patients at revision arthroplasty performed more than 10 years after primary arthroplasty. The results of this preliminary study suggest that future epidemiologic studies should concentrate on patients with longer postoperative intervals to see if there is any risk that would be pertinent to a young patient at primary arthroplasty.
authors.affiliation: Department of Histopathology, University of Bristol, United Kingdom.
authors.forename: C P
authors.initials: CP
authors.lastname: Case
authors.forename: V G
authors.initials: VG
authors.lastname: Langkamer
authors.forename: R T
authors.initials: RT
authors.lastname: Howell
authors.forename: J
authors.initials: J
authors.lastname: Webb
authors.forename: G
authors.initials: G
authors.lastname: Standen
authors.forename: M
authors.initials: M
authors.lastname: Palmer
authors.forename: A
authors.initials: A
authors.lastname: Kemp
authors.forename: I D
authors.initials: ID
authors.lastname: Learmonth
mesh_terms: D000368:Aged; D001483:Base Sequence; D001672:Biocompatible Materials / Q000633:toxicity*; D019046:Bone Marrow Neoplasms / Q000139:chemically induced*; D002869:Chromosome Aberrations; D003343:Corrosion; D017931:DNA Primers / Q000235:genetics; D015321:Gene Rearrangement; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D008670:Metals / Q000032:analysis; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000139:chemically induced*
chemical_list: D001672:Biocompatible Materials; D017931:DNA Primers; D008670:Metals