title: Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases.
abstract: CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.
authors.affiliation: Clinica Dermatologica I dell'Università di Torino, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Novelli
authors.forename: P
authors.initials: P
authors.lastname: Savoia
authors.forename: M T
authors.initials: MT
authors.lastname: Fierro
authors.forename: A
authors.initials: A
authors.lastname: Verrone
authors.forename: P
authors.initials: P
authors.lastname: Quaglino
authors.forename: M G
authors.initials: MG
authors.lastname: Bernengo
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000276:immunology; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology; D009182:Mycosis Fungoides / Q000276:immunology; D012751:Sezary Syndrome / Q000276:immunology; D012867:Skin / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D018819:Dipeptidyl Peptidase 4