Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic.
By using an amplification-created restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis. The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.
Chu
C M
CM
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.
Yeh
C T
CT
Chiu
C T
CT
Sheen
I S
IS
Liaw
Y F
YF
D000208:Acute Disease; D000328:Adult; D001483:Base Sequence; D002353:Carrier State / Q000453:epidemiology / Q000821:virology; D016022:Case-Control Studies; D002908:Chronic Disease; D018388:Codon, Terminator / Q000235:genetics; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D006509:Hepatitis B / Q000453:epidemiology / Q000821:virology*; D006513:Hepatitis B e Antigens / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D017354:Point Mutation; D013624:Taiwan / Q000453:epidemiology
D018388:Codon, Terminator; D017931:DNA Primers; D004279:DNA, Viral; D006513:Hepatitis B e Antigens