title: Use of bioelectrical impedance analysis measurements in patients with diabetes. The Diabetes Control and Complications Trial Research Group.
abstract: Weight gain is an important consequence of the intensive treatment of insulin-dependent diabetes mellitus (IDDM). Despite this, body composition in this disorder has not been well studied. Bioelectrical impedance analysis (BIA) has been shown to be a reliable, noninvasive method of assessing body composition but little is known about its use in IDDM. Therefore, a regression model estimating fat-free volume mass from bioelectrical impedance measurements obtained with proximal electrode placements was developed in 46 adults with IDDM through use of dual-energy X-ray absorptiometry (DXA) for reference values of fat-free mass. No effect of blood glucose concentration or prandial state on the impedance characteristics was observed. A regression model was developed incorporating the ratio of height squared to the minimum resistance of four limb-lead combinations (H2/R), total body weight, and a weight-sex interaction. With this model, BIA correlated closely with DXA (R2 = 0.982, residual SD = 1.3 kg). The applicability of these equations to non-insulin-dependent diabetes mellitus is unknown.
authors.affiliation: Department of Medicine, University of Toronto, St Michael's Hospital, Ontario, Canada.
authors.forename: L A
authors.initials: LA
authors.lastname: Leiter
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D017097:Electric Impedance; D006801:Humans; D008954:Models, Biological; D010865:Pilot Projects; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose