title: Skeletal muscle contractile characteristics and fatigue resistance in patients with chronic heart failure.
abstract: Whole muscle contractile characteristics and fatigue resistance were studied in male patients with chronic heart failure (n = 6) and in healthy control subjects (n = 6). Maximum voluntary isometric strength in the major muscle groups of leg (plantar flexors and knee extensors) and arm (elbow extensors and elbow flexors), was found to be similar for both groups of subjects. However, a faster isometric twitch time course was observed in the plantar flexor and knee extensor muscles of heart failure chronic patients. The poor resistance to fatigue in the knee extensors of chronic heart failure patients was confirmed in the present study, but using twitch interpolation this was shown not to be due to poor activation. The plantar flexors of chronic heart failure patients also showed a tendency to be less resistant to fatigue, even when the muscle was activated by direct electrical stimulation. The present study shows that independent of muscle strength, patients with chronic heart failure may possess muscles that are faster to contract and less resistant to fatigue. However, it seems this increased fatigability is not due to poor muscle activation.
authors.affiliation: Department of Physiology and Pharmacology, Physiology III, Karolinska Institute; Stockholm, Sweden.
authors.forename: S D
authors.initials: SD
authors.lastname: Harridge
authors.forename: G
authors.initials: G
authors.lastname: Magnusson
authors.forename: A
authors.initials: A
authors.lastname: Gordon
mesh_terms: D002908:Chronic Disease; D015444:Exercise; D005221:Fatigue; D018737:Hand Strength; D006333:Heart Failure; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D012016:Reference Values