Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?
Christians
U
U
Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Germany.
Bleck
J S
JS
Lampen
A
A
Bader
A
A
Thiesemann
C
C
Kliem
V
V
Repp
H
H
Westhoff-Bleck
M
M
Manns
M
M
Sewing
K F
KF
D000293:Adolescent; D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D016572:Cyclosporine / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology*; D004386:Duodenum; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000201:enzymology*; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008657:Metabolic Clearance Rate; D008861:Microsomes / Q000201:enzymology; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D012727:Sex Characteristics
D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019392:Cytochrome P-450 CYP2E1; D004110:Diltiazem