[Biochemical changes in fibromyalgia].
Different changes in neurotransmitters were observed in patients with fibromyalgia. The aim of the study was to confirm the diagnosis fibromyalgia by determination of several of these substances. In 60 patients, who met the ACR classification criteria for fibromyalgia and in 20 sex and age matched controls the following estimations were made: serotonin (EIA), somatomedin C (RIA), calcitonin (RIA), prostaglandin E2 (EIA), oxytocin (RIA), ACTH (RIA), substance P (EIA), TSH (LIA), prolactin (LIA). In comparison to healthy controls, patients with fibromyalgia revealed significantly decreased levels of serotonin, somatomedin C, calcitonin, prostaglandin E2 and a significantly increased level of prolactin. No significant differences were found in the levels of ACTH, substance P and TSH. These results suggest that the diagnosis of fibromyalgia can be confirmed by various biochemical parameters, but further investigations must be carried out to value the diagnostic relevance of these findings.
Samborski
W
W
Hochrheininstitut für Rehabilitationsforschung, Bad Säckingen.
Stratz
T
T
Schochat
T
T
Mennet
P
P
Müller
W
W
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D015232:Dinoprostone / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000175:diagnosis*; D006728:Hormones / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D018377:Neurotransmitter Agents / Q000097:blood*; D010121:Oxytocin / Q000097:blood; D011388:Prolactin / Q000097:blood; D012701:Serotonin / Q000097:blood; D013373:Substance P / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D006728:Hormones; D018377:Neurotransmitter Agents; D012701:Serotonin; D013373:Substance P; D010121:Oxytocin; D007334:Insulin-Like Growth Factor I; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D015232:Dinoprostone
Biochemische Veränderungen bei der Fibromyalgie.