[Influence of genetic factors on multiple sclerosis].
Epidemiological studies have provided evidence for a genetic contribution to the susceptibility of multiple sclerosis (MS). One in six patients has at least one affected family member. The concordance rate is approximately 25% in monozygotic twins, and 3% in siblings, however the prevalence in adopted siblings is similar to the general population (0.1%) MS is thought to be a T cell-mediated autoimmune disease and therefore genes controlling the immune response have been studied intensively as potential susceptibility factors. The best documented association was found for genes of the human-leukocyte antigen complex. Other possible susceptibility genes may reside in the regions of the T cell receptors and the tumour necrosis factors. So far it is clear, that MS is a multifactorial disease in which several genes must be involved. Population genetics and molecular biology will help to characterise further these susceptibility factors.
Sommer
N
N
Neurologische Universitätsklinik, Eberhard-Karls-Universität, Tübingen.
Zipp
F
F
Rösener
M
M
Dichgans
J
J
Martin
R
R
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D002896:Chromosomes, Human, Pair 6; D016207:Cytokines / Q000502:physiology; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D018433:Twin Studies as Topic; D014430:Twins, Monozygotic / Q000235:genetics
D016207:Cytokines; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell; D014409:Tumor Necrosis Factor-alpha
Der Einfluss genetischer Faktoren auf die multiple Sklerose.