An ovine lymphocyte antigen is associated with reduced faecal egg counts in four-month-old lambs following natural, predominantly Ostertagia circumcincta infection.
Ovine lymphocyte antigen is associated with reduced faecal egg counts in 4-month-old lambs following natural, predominantly Ostertagia circumcincta infection. International Journal for Parasitology 26: 423-428. Ten lymphocyte antigens were defined in a flock of Scottish Blackface sheep known to be naturally exposed to infection with Ostertagia circumcincta. Population and family studies suggested that the 10 antigens were products of class I loci. Antigen G13br was in linkage disequilibrium with allele g2 at the DRB1 locus. The g2 allele has previously been associated with reduced faecal egg counts in a different crop of lambs from the same farm. In this study antigen G13br was also associated with a reduction in faecal egg counts. The results provide partial confirmation of the role of the major histocompatibility complex in resistance to natural, predominantly O. circumcincta infection.
Stear
M J
MJ
Glasgow University Veterinary School, Scotland.
Bairden
K
K
Bishop
S C
SC
Buitkamp
J
J
Epplen
J T
JT
Gostomski
D
D
McKellar
Q A
QA
Schwaiger
F W
FW
Wallace
D S
DS
D000483:Alleles; D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D017353:Gene Deletion; D005819:Genetic Markers; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D015810:Linkage Disequilibrium; D008214:Lymphocytes / Q000276:immunology*; D008285:Major Histocompatibility Complex; D010028:Ostertagia / Q000276:immunology*; D010029:Ostertagiasis / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases
D005819:Genetic Markers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I