Montiporic acids A and B, cytotoxic and antimicrobial polyacetylene carboxylic acids from eggs of the scleractinian coral Montipora digitata.
Two new polyacetylene carboxylic acids, montiporic acids A (1) and B (2), have been isolated from the eggs of the scleractinian coral Montipora digitata and their structures elucidated on the basis of spectroscopic data. They exhibited antimicrobial activity against Escherichia coli and cytotoxicity against P-388 murine leukemia cells.
Fusetani
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N
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan. anobu@hongo.ecc.u-tokyo.ac.jp
Toyoda
T
T
Asai
N
N
Matsunaga
S
S
Maruyama
T
T
D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002264:Carboxylic Acids; D002455:Cell Division / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects*; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010063:Ovum; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000085:Acetates; D000480:Alkynes; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002264:Carboxylic Acids; C102978:montiporic acid A; C102979:montiporic acid B; D000114:Acetylene