title: [Metabolic study of mitochondria in myocardial biopsies in patients with cardiopathy of unknown origin].
abstract: BACKGROUND
  Mitochondrial cardiomyopathies are being studied as metabolic diseases of the cardiac muscle which represents a new approach in metabolic studies. The development of mitochondrial diseases is concomited by an impairment in complexes of mitochondrial respiratory chain, which so far could have been possibly studied exclusively on experimental animals. The method of skinned? fibers enables to measure the pathobiochemical processes in mitochondria in a small amount of bioptic myocardial tissue of patients.
  
  
  OBJECTIVE
  The study is aimed at: applying the method of skinned fibers in biopsy of myocardium in patients, trying to localize the impaired loci of the mitochondrial respiratory chains, prospective early and fast assessment of the diagnosis of mitochondrial cardiomyopathy in patients.
  
  
  CONCLUSIONS
  The study brings the first information on the possibility of performing more value measurements of mitochondrial respiratory chains per one bioptic sample from the myocardium in patients. The preliminary results indicate to the prospective possibility of early and fast assessment of the diagnosis of mitochondrial cardio(myo)pathies. The presented results require complementary studies involving the development of "mitochondrial medicine".
authors.affiliation: Farmakobiochemické laboratórium III. internej kliniky Lekárskej fakulty, Univerzity Komenského v Bratislave, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Gvozdjáková
authors.forename: J
authors.initials: J
authors.lastname: Kucharská
authors.forename: S
authors.initials: S
authors.lastname: Mizera
authors.forename: M
authors.initials: M
authors.lastname: Snircová
authors.forename: Z
authors.initials: Z
authors.lastname: Schreinerová
authors.forename: E
authors.initials: E
authors.lastname: Schrameková
authors.forename: I
authors.initials: I
authors.lastname: Pechán
authors.forename: J
authors.initials: J
authors.lastname: Fabián
mesh_terms: D001706:Biopsy; D009202:Cardiomyopathies / Q000209:etiology / Q000378:metabolism*; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000378:metabolism*; D017240:Mitochondrial Myopathies / Q000175:diagnosis; D009206:Myocardium / Q000473:pathology*; D009243:NAD / Q000378:metabolism; D010101:Oxygen Consumption; D014451:Ubiquinone / Q000378:metabolism
chemical_list: D009243:NAD; D014451:Ubiquinone; D005182:Flavin-Adenine Dinucleotide
vernacular_title: Metabolické stúdie mitochondrií v biopsiách myokardu u pacientov s kardiopatiami nejasného pôvodu.