title: Sustained release of fleroxacin in vitro from lactic acid polymer.
abstract: The time-delayed release of fleroxacin, a newer fluoroquinolone, from a mixture of racemic D-L-Lactic acid is reviewed. Ten in vitro experiments for each fleroxacin concentration of 1% and 10%, were performed. Pre-formed D-L-Lactic acid, plus fleroxacin clots were preserved in sterile 1 cm diameter tubes with one ml of nutrient broth at 37 degrees C until they were fully disintegrated. Every 24 hours the tubes were sampled and replaced by standard broth volumes. Fleroxacin levels were measured by a microbiological method. The release of fleroxacin impregnated in D-L-Lactic acid clots in these two concentrations (1% and 10%) is very promising; the levels obtained over a two month period were much higher than the minimum bacterial concentration of the expected pathogens implicated in bone infections.
authors.affiliation: Department of Orthopaedics, LAIKO General Hospital, Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Dounis
authors.forename: T
authors.initials: T
authors.lastname: Korakis
authors.forename: A
authors.initials: A
authors.lastname: Anastasiadis
authors.forename: K
authors.initials: K
authors.lastname: Kanellakopoulou
authors.forename: A
authors.initials: A
authors.lastname: Andreopoulos
authors.forename: H
authors.initials: H
authors.lastname: Giamarellou
mesh_terms: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016576:Fleroxacin / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D019344:Lactic Acid; D011108:Polymers
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D019344:Lactic Acid; D016576:Fleroxacin