Effect of oral Sulfenamide TS administration on prenatal development in rats.
Sulfenamide TS (N-cyclohexyl-2-benzothiazolesulfenamide), accelerator of rubber vulcanization, was administered to female rats by gavage at doses of 50, 150, and 450 mg/kg (1%, 3%, and 8% of LD50) during organogenesis. The maternal toxicity of Sulfenamide TS was found at the highest dose of 450 mg/kg. Oral administration of this compound to female rats during organogenesis induced fetotoxic effects at doses of 50 mg/kg and higher. The dose-dependent increase in the frequency of fetuses/ litters with internal hydrocephalus was observed.
Sitarek
K
K
Department of Carcinogenesis, Teratogenesis, and Mutagenesis, Nofer Institute of Occupational Medicine, Lódź, Poland.
Berlińska
B
B
Barański
B
B
D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000818:Animals; D052160:Benzothiazoles; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D006849:Hydrocephalus / Q000139:chemically induced; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000187:drug effects / Q000473:pathology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013844:Thiazoles / Q000008:administration & dosage / Q000633:toxicity*
D052160:Benzothiazoles; D013844:Thiazoles; C044169:thiohexam