title: Effect of supplemental chromium on antibody responses of newly arrived feeder calves to vaccines and ovalbumin.
abstract: Two trials were conducted to investigate the effects of supplemental chromium (Cr) from organic sources (Cr chelate and high Cr yeast) on antibody responses of newly arrived feeder calves following vaccination with infectious bovine rhinotracheitis (IBR), para-influenza-3 (PI3), bovine respiratory syncytial virus (BRSV), bovine viral diarrhea (BVD) and Pasteurella haemolytica and ovalbumin (OVA). Using cross bred steer calves purchased at sales in Ontario, vaccines and OVA were given on d 0 and 21 after arrival in the feedlot. Immune responses of calves were measured as serum specific antibody titres against all antigens on d 0 and 28 or d 35. The anti-OVA antibody responses (trial 2) were further investigated by measuring antibody concentrations of calves weekly until d 55 after arrival in the feedlot. Supplemental Cr (0.14 ppm) from an amino acid-chelated source had no effect on antibody responses to IBR, P13 and BRSV, but enhanced (P < 0.05) antibody titres of calves in response to the BVD vaccine on d 28 or d 35. Supplemental Cr from Cr yeast had no effect on antibody titres of calves to any vaccines. Chromium from both sources (trial 1 and 2) had no effect on antibody responses of calves following vaccination with P. haemolytica. However, supplemental Cr (0.75 ppm) from Cr yeast enhanced (P < 0.05) serum antibody responses of calves to OVA during the primary response (d 14) and secondary response (d 35) following immunization. These data confirmed our previous finding that supplemental Cr can enhance humoral immune response of market-transit stressed calves, but its enhancement on vaccine efficacy was antigen-dependent and variable.
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Ontario.
authors.forename: G X
authors.initials: GX
authors.lastname: Chang
authors.forename: B A
authors.initials: BA
authors.lastname: Mallard
authors.forename: D N
authors.initials: DN
authors.lastname: Mowat
authors.forename: G F
authors.initials: GF
authors.lastname: Gallo
mesh_terms: D000821:Animal Feed; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001428:Bacterial Vaccines / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases; D002857:Chromium / Q000008:administration & dosage / Q000494:pharmacology*; D005527:Food, Fortified; D008297:Male; D016978:Mannheimia haemolytica; D009919:Orchiectomy; D010047:Ovalbumin / Q000276:immunology*; D010326:Pasteurella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines; D002857:Chromium; D010047:Ovalbumin