Recent advances in understanding signal transduction pathways in worms and flies.
One major challenge in the fields of signal transduction and pattern formation is to understand how multiple signals are integrated to determine cell fates. Two developmental systems, vulval development in Caenorhabditis elegans and axis formation during Drosophila melanogaster oogenesis, require the epidermal growth factor receptor tyrosine kinase and the NOTCH signaling pathways to specify cell fates. Current work in both systems has provided new opportunities to investigate the potential for the cross-talk between these different signaling pathways.
Duffy
J B
JB
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Alpert Building, 200 Longwood Avenue, Boston, MA 02115, USA.
Perrimon
N
N
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D005544:Forecasting; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009865:Oocytes; D011494:Protein Kinases; D018010:Receptors, Invertebrate Peptide / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*
D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D018010:Receptors, Invertebrate Peptide; D051880:Receptors, Notch; D011494:Protein Kinases; C066532:Egfr protein, Drosophila; D066246:ErbB Receptors