title: Effects of short-term treatment with the thromboxane synthesis blocker indobufen on pressor and depressor humoral factors in healthy humans.
abstract: Twelve healthy subjects were studied after single dose (200 mg p.o.) and 3 days (2 x 200 mg daily p.o.) indobufen treatment. Our findings indicated that in addition to well-known antiaggregant activity, indobufen significantly decreases thromboxane B2 and increases 6-keto-prostaglandin F1 after acute and short-term treatment. The activity of renin-angiotensin-aldosterone system and kallikrein-kinin system did not change significantly after both experimental periods. It seems also unlikely that atrial natriuretic peptide mediates the effects of the drug.
authors.affiliation: Clinical Center of Endocrinology and Gerontology, Sofia, Bulgaria.
authors.forename: S
authors.initials: S
authors.lastname: Zacharieva
authors.forename: M
authors.initials: M
authors.lastname: Orbetzova
authors.forename: D
authors.initials: D
authors.lastname: Tcharaktchiev
authors.forename: P
authors.initials: P
authors.lastname: Angelova-Gateva
authors.forename: K
authors.initials: K
authors.lastname: Andonova
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D013997:Time Factors
chemical_list: D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; D000450:Aldosterone; C020371:indobufen; D012083:Renin