title: An ovine lymphocyte antigen is associated with reduced faecal egg counts in four-month-old lambs following natural, predominantly Ostertagia circumcincta infection.
abstract: Ovine lymphocyte antigen is associated with reduced faecal egg counts in 4-month-old lambs following natural, predominantly Ostertagia circumcincta infection. International Journal for Parasitology 26: 423-428. Ten lymphocyte antigens were defined in a flock of Scottish Blackface sheep known to be naturally exposed to infection with Ostertagia circumcincta. Population and family studies suggested that the 10 antigens were products of class I loci. Antigen G13br was in linkage disequilibrium with allele g2 at the DRB1 locus. The g2 allele has previously been associated with reduced faecal egg counts in a different crop of lambs from the same farm. In this study antigen G13br was also associated with a reduction in faecal egg counts. The results provide partial confirmation of the role of the major histocompatibility complex in resistance to natural, predominantly O. circumcincta infection.
authors.affiliation: Glasgow University Veterinary School, Scotland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Stear
authors.forename: K
authors.initials: K
authors.lastname: Bairden
authors.forename: S C
authors.initials: SC
authors.lastname: Bishop
authors.forename: J
authors.initials: J
authors.lastname: Buitkamp
authors.forename: J T
authors.initials: JT
authors.lastname: Epplen
authors.forename: D
authors.initials: D
authors.lastname: Gostomski
authors.forename: Q A
authors.initials: QA
authors.lastname: McKellar
authors.forename: F W
authors.initials: FW
authors.lastname: Schwaiger
authors.forename: D S
authors.initials: DS
authors.lastname: Wallace
mesh_terms: D000483:Alleles; D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D017353:Gene Deletion; D005819:Genetic Markers; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D015810:Linkage Disequilibrium; D008214:Lymphocytes / Q000276:immunology*; D008285:Major Histocompatibility Complex; D010028:Ostertagia / Q000276:immunology*; D010029:Ostertagiasis / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases
chemical_list: D005819:Genetic Markers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I