[The immunogenic and protective properties of the cell wall proteins of Listeria monocytogenes].
Two protein antigens with molecular weights of 58 kD (antigen Lm58) and 79/39 kD (antigen Lm79/ 39) were isolated from Listeria monocytogenes cell wall. Only Lm79/39 was shown to protect mice from L. monocytogenes infection, increasing their LD50 and survival time. The protective activity of Lm79/39 correlated (r = 0.64) with its mitogenic properties and its capacity for activating the production of interleukin-1- and interleukin-2-like factors. More over Lm79/ 39 induced more strong than Lm58 specific lymphocyte proliferation. The two antigens had practically no difference in their capacity for cytotoxic cell activation. The protective activity of Lm79/39 is probably linked with its immunomodulating properties, which opens a perspective for its use as a component of an antilisteriosis vaccine.
Pronin
A V
AV
Belyĭ
Iu F
IuF
Bdeui
I
I
Deeva
A V
AV
Tartakovskiĭ
I S
IS
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D007114:Immunization; D008089:Listeria monocytogenes / Q000276:immunology* / Q000472:pathogenicity; D008088:Listeriosis / Q000276:immunology / Q000517:prevention & control; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D012692:Serial Passage; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014774:Virulence / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins
Immunogennye i protektivnye svoĭstva belkov keltochnoĭ stenki Listeria monocytogenes.