A brute force dichotomization approach to quantitative trait linkage analysis.
The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed.
Bailey
J N
JN
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA.
Almasy
L
L
D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D010641:Phenotype; D011237:Predictive Value of Tests; D012984:Software