[Analysis of reaction time in post-acute schizophrenia using electrophysiologic variables].
20 postacute schizophrenic patients with predominantly negative symptoms and 21 age and sex matched normal controls were investigated in a P300 paradigm with simultaneous measurement of EP, EMG and behavioural reaction time. The steps of central information processing were operationalized by the following measures: input processing time (IPT): N1-latency; central processing time (CPT): N1-latency until EMG-onset; motor execution time (MET): EMG-onset until onset of target behaviour. For the schizophrenic group we found a pattern of significant deviations with reduction of the N1-, N2- and P3-amplitude, prolongation of the central processing, motor execution and behavioural termination time. The largest loss of time however was found for the central information processing time (203.1 +/- 72.9 vs. 113.1 vs. 20.2 ms, p = 0.000). In the control group the EMG reaction started 12.4 ms before the N2 peak, in the schizophrenic group 63.5 ms after the N2 peak (p = 0.02). Summing up, these findings are compatible with the assumption of a multiple functional deficit of central information processing in schizophrenia.
Eichert
V
V
Psychiatrische Klinik, Universität Bonn.
Klosterkötter
J
J
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001288:Attention / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents
Reaktionszeitanalyse bei postakut Schizophrenen mit Hilfe elektrophysiologischer Variablen.