title: Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: a report of the CHAMP collaborative study group. CHromosomes And MorPhology.
abstract: Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-12 aberrations. All 4 tumors with loss of segments from 12q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of 12q material were diagnosed as ALT. One or three extra copies of 12q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: M
authors.initials: M
authors.lastname: Akerman
authors.forename: P
authors.initials: P
authors.lastname: Aman
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: I
authors.initials: I
authors.lastname: De Wever
authors.forename: C D
authors.initials: CD
authors.lastname: Fletcher
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: J
authors.initials: J
authors.lastname: Rosai
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: G
authors.initials: G
authors.lastname: Tallini
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: W
authors.initials: W
authors.lastname: Van de Ven
authors.forename: R
authors.initials: R
authors.lastname: Vanni
authors.forename: H
authors.initials: H
authors.lastname: Willén
mesh_terms: D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics*; D008297:Male; D005810:Multigene Family