title: Cellular activity in e-PTFE reconstructed pulleys and adjacent regions of deep flexor tendons. An experimental biochemical study in rabbits.
abstract: The biological adaptation and integration of flexor tendon pulleys reconstructed with expanded polytetrafluorethylene (e-PTFE) were investigated 3 months after operation. E-PTFE pulleys showed no signs of failure, adverse tissue reactions or detrimental effects on the surface of underlying tendons. Cells in pulleys reconstructed with e-PTFE synthesized proteoglycan, collagen and non-collagen protein at a higher rate, and DNA at a lower rate, than cells in sham operated pulleys. Cells in pulleys reconstructed with e-PTFE synthesized proteoglycan at a lower rate, and protein at a higher rate, than cells in e-PTFE strips placed subcutaneously. Flexor tendon segments underlying reconstructed or sham operated pulleys synthesized matrix components and DNA at comparable rates.
authors.affiliation: Department of Hand Surgery, University Hospital, Malmö, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Hanff
authors.forename: S O
authors.initials: SO
authors.lastname: Abrahamsson
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001672:Biocompatible Materials; D002455:Cell Division; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis; D004867:Equipment Design; D004868:Equipment Failure; D005109:Extracellular Matrix / Q000378:metabolism; D005549:Foreign-Body Reaction; D006614:Hindlimb / Q000601:surgery; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants; D014176:Protein Biosynthesis; D011509:Proteoglycans / Q000096:biosynthesis; D011817:Rabbits; D013462:Sulfur Radioisotopes; D013710:Tendons / Q000166:cytology / Q000378:metabolism / Q000601:surgery*; D014316:Tritium
chemical_list: D001672:Biocompatible Materials; D011509:Proteoglycans; D013462:Sulfur Radioisotopes; D014316:Tritium; D011138:Polytetrafluoroethylene; D003094:Collagen; D004247:DNA