title: [Do an operation and radiotherapy in the breast-preserving therapy of breast carcinoma modify the meaningfulness of subsequent mammographies?].
abstract: OBJECTIVE
  Today, whenever possible, mamma carcinoma is operated on by preserving as much breast as possible, and is followed by postoperative radiotherapy of the thoracic wall. This form of treatment can lead to alterations of the skin and parenchyma, visible in mammogram, which may make evaluation of these mammographies difficult with regard to recidive. This paper presented describes nature and frequency of changes of treated breast caused by therapy.
  
  
  METHODS
  Three hundred and eighty mammographies of 50 female patients were evaluated on alterations of skin and parenchyma caused by combined therapy. Inclusive criteria were among others 2 mammographies in the 1st year after therapy, no advanced or parallel chemotherapy and a follow-up time of at least 5 years.
  
  
  RESULTS
  Thirty-two patients (64%) showed no fibrotic changes of breast, 5 patients (10%) initially developed denseness of parenchyma which then, however, reverted back to a completely normal state. Only 13 patients (26%) had irreversible fibrotic alterations of parenchyma, only 3 (6%) of which showed extensive fibrosis which definitely might make recidive diagnostic difficult.
  
  
  CONCLUSIONS
  Major changes of parenchyma caused by preparatory treatment which can be registered by mammography are relatively rare. For this reason, mammography maintains its unchanged high position within post-tumorous treatment, especially as it even today is the only diagnostic method to evidence microcalcifications suspect of being malignant.
authors.affiliation: Abteilung für Strahlentherapie, Philipps-Universität Marburg.
authors.forename: H
authors.initials: H
authors.lastname: Proske
authors.forename: C
authors.initials: C
authors.lastname: Kotitschke-Christ
authors.forename: R
authors.initials: R
authors.lastname: Pfab
mesh_terms: D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D005355:Fibrosis; D005500:Follow-Up Studies; D006801:Humans; D008327:Mammography; D015412:Mastectomy, Segmental; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies
vernacular_title: Beeinflussen Operation und Strahlentherapie bei der brusterhaltenden Therapie des Mammakarzinoms die Aussagekraft nachfolgender Mammographien?