Synthesis and pharmacological investigations of 1,2,3,4-tetrahydroisoquinoline derivatives.
Selected 1-aryl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated as beta-adreno-receptor agents. Some of the compounds showed week agonistic or antagonistic activity on these receptors.
Brzezinska
E
E
Institute of Chemistry and Technology of Drugs, Medical University, Lódź, Poland.
Venter
D
D
Glinka
R
R
D058665:Adrenergic beta-1 Receptor Agonists; D058671:Adrenergic beta-1 Receptor Antagonists; D058666:Adrenergic beta-2 Receptor Agonists; D058672:Adrenergic beta-2 Receptor Antagonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001993:Bronchodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D044005:Tetrahydroisoquinolines; D014132:Trachea / Q000187:drug effects
D058665:Adrenergic beta-1 Receptor Agonists; D058671:Adrenergic beta-1 Receptor Antagonists; D058666:Adrenergic beta-2 Receptor Agonists; D058672:Adrenergic beta-2 Receptor Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D001993:Bronchodilator Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C014843:1,2,3,4-tetrahydroisoquinoline; D011433:Propranolol; D007545:Isoproterenol