title: The effects of xylazine on plasma concentrations of growth hormone, insulin-like growth factor-I, glucose and insulin in calves.
abstract: The purpose of the present study was to examine the responses of plasma growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels to intravenous injection of xylazine in female dairy calves. Xylazine (0.05, 0.15 and 0.30 mg/kg body wt., i.v.) injections induced a significant dose-dependent increase in plasma GH level within 30 min. After plasma GH levels reached peaks, GH concentrations began to decrease immediately and they returned to control levels 1 h after xylazine injection. Plasma IGF-I concentration tended to be suppressed by xylazine treatment. Xylazine induced a significant dose-dependent increase in plasma glucose for 3.5 to 5.5 h after the treatments. Xylazine also induced a significant decrease in plasma insulin level within 30 min after treatments. The present data suggested that xylazine stimulates GH release in cattle.
authors.affiliation: Laboratory of Animal Reproduction, Faculty of Agriculture, Iwate University, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kasuya
authors.forename: K
authors.initials: K
authors.lastname: Hodate
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: T
authors.initials: T
authors.lastname: Hashizume
authors.forename: S
authors.initials: S
authors.lastname: Kanematsu
mesh_terms: D000700:Analgesics; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002417:Cattle / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007700:Kinetics; D014991:Xylazine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000700:Analgesics; D001786:Blood Glucose; D007328:Insulin; D014991:Xylazine; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone