title: Absence of effect of trimethoprim-sulfamethoxazole on pharmacokinetics of zidovudine in patients infected with human immunodeficiency virus.
abstract: Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim-sulfamethoxazole by oral administration. ZDV areas under the concentration-time curves were (means +/- standard deviations) 1.80 +/- 0.70 and 1.69 +/- 0.64 micrograms.h/ml in the absence and presence of trimethoprim-sulfamethoxazole, respectively. ZDV clearances were 1.57 +/- 0.61 and 1.74 +/- 0.66 liters/h/kg, respectively.
authors.affiliation: Infectious Diseases Unit, Hospital Universitario Virgen del Rocio, Seville, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Cañas
authors.forename: J
authors.initials: J
authors.lastname: Pachon
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Pesquera
authors.forename: J R
authors.initials: JR
authors.lastname: Castillo
authors.forename: P
authors.initials: P
authors.lastname: Viciana
authors.forename: J M
authors.initials: JM
authors.lastname: Cisneros
authors.forename: M E
authors.initials: ME
authors.lastname: Jimenez-Mejias
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000378:metabolism; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*; D015215:Zidovudine / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D015215:Zidovudine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination