title: A porcine model of chronic peripheral arterial occlusion.
abstract: OBJECTIVE
  To create a simple and reproducible model of chromic thrombosis for the evaluation of thrombolytic agents and devices.
  
  
  METHODS
  A stenosis was created in the superficial femoral artery of domestic swine, and autologous blood clot was deposited above the stenosis. Follow-up last for up to 3 months. Degree of clot organization was determined at histologic examination. Two thrombolytic agents, urokinase and collagenase, were used to test this model.
  
  
  RESULTS
  There was a 27% delayed recanalization rate with this model. At histologic examination, early thrombus organization was seen at the vessel periphery after 10 days. One-month-old thrombus was substantial but variable in amount. Three-month-old thrombus was completely organized. Neither urokinase nor collagenase proved effective against chronic clot in the doses and time course of this study.
  
  
  CONCLUSIONS
  This simple method yields a chronic porcine clot in a reliable number of domestic swine in 1 month.
authors.affiliation: Department of Radiological Science, University of California, School of Medicine, Los Angeles 90024.
authors.forename: H C
authors.initials: HC
authors.lastname: Yoon
authors.forename: S C
authors.initials: SC
authors.lastname: Goodwin
authors.forename: J
authors.initials: J
authors.lastname: Ko
authors.forename: E
authors.initials: E
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Rosedale
mesh_terms: D000818:Animals; D017364:Collagenases / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005263:Femoral Artery; D010960:Plasminogen Activators / Q000627:therapeutic use*; D011859:Radiography; D013552:Swine; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator; D017364:Collagenases