Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism.
The non-Abeta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/alpha-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.
Xia
Y
Y
Department of Neurosciences, School of Medicine, UCSD, La Jolla, CA 92093-0949, USA.
Rohan de Silva
H A
HA
Rosi
B L
BL
Yamaoka
L H
LH
Rimmler
J B
JB
Pericak-Vance
M A
MA
Roses
A D
AD
Chen
X
X
Masliah
E
E
DeTeresa
R
R
Iwai
A
A
Sundsmo
M
M
Thomas
R G
RG
Hofstetter
C R
CR
Gregory
E
E
Hansen
L A
LA
Katzman
R
R
Thal
L J
LJ
Saitoh
T
T
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D000682:Amyloid / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D001483:Base Sequence; D046508:Culture Techniques; D008040:Genetic Linkage; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics*; D051843:Synucleins; D014158:Transcription, Genetic
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D051843:Synucleins