title: Cyclic Cushing's disease in long-term remission with a daily low dose of bromocriptine.
abstract: A 56-year-old male patient with cyclic Cushing's disease remained in a state of remission for more than one year with a relatively low dose of bromocriptine (2.5-3.75 mg/day). It has been reported that bromocriptine treatment for cyclic Cushing's disease induces only a transient remission; in the most effective cases, a relatively high dose (40 mg/day) was necessary. In the hypercortisolemic state, plasma adrenocorticotropic hormone (ACTH) and serum cortisol were not suppressed by dexamethasone and did not respond to corticotropin-releasing factor (CRF). An antehypophysectomy was not effective, even though the resected tissue contained ACTH-positive microadenomas. The present observations thus indicate the effectiveness of bromocriptine for some patients with this rare disorder.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: R
authors.initials: R
authors.lastname: Takayanagi
authors.forename: T
authors.initials: T
authors.lastname: Yanase
authors.forename: Y
authors.initials: Y
authors.lastname: Sakai
authors.forename: S
authors.initials: S
authors.lastname: Ikuyama
authors.forename: H
authors.initials: H
authors.lastname: Nakagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Osamura
authors.forename: N
authors.initials: N
authors.lastname: Sanno
authors.forename: H
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors / Q000097:blood; D001971:Bromocriptine / Q000008:administration & dosage / Q000627:therapeutic use*; D003480:Cushing Syndrome / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000097:blood; D007016:Hypophysectomy; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D012074:Remission Induction / Q000379:methods
chemical_list: D018492:Dopamine Antagonists; D001971:Bromocriptine; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone