title: Pseudoallergic skin reactions to opiate sequences of bovine casein in healthy children.
abstract: Skin tests with opioid peptides naturally occurring in cow's milk: beta-casomorphin-7 and alpha-casein (90-95), were performed in 25 healthy children. Wheal and flare reactions, similiar to histamine and codeine were observed in all children. The area of these reactions was concentration dependent. Pretreatment with H1 antagonist--cetirizine significantly inhibited the skin response to both peptides. Beta-casomorphin-7 and alpha-casein (90-95) are noncytotoxic histamine releasers in humans.
authors.affiliation: Department of Gastroenterology, Academy of Medicine, Gdańsk.
authors.forename: M
authors.initials: M
authors.lastname: Kurek
authors.forename: M
authors.initials: M
authors.lastname: Czerwionka-Szaflarska
authors.forename: G
authors.initials: G
authors.lastname: Doroszewska
mesh_terms: D000293:Adolescent; D002364:Caseins / Q000276:immunology*; D005260:Female; D006636:Histamine Release; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D018847:Opioid Peptides / Q000276:immunology
chemical_list: D002364:Caseins; D018847:Opioid Peptides