title: The stimulation and inhibition of T cell proliferation by Helicobacter pylori components.
abstract: The purified T cells from peripheral blood of healthy human volunteers, seronegative for anti-Helicobacter pylori antibody were stimulated in cultures with live or heat-killed H. pylori rods or with bacterial sialic acid-specific surface haemagglutinin (sHA), a crude surface (SF) or cytoplasmic (CF) fractions. It is demonstrated that H. pylori bacteria contain both stimulatory and inhibitory components for T cells of healthy individuals. The sHA as well as SF (5-20 micrograms) induced the proliferative response of T lymphocytes. By contrast, CF inhibited in dose dependent manner, the proliferation of T cells in the cultures stimulated with H. pylori bacteria or PHA. The result suggest that in vivo, a dominance of activation or immunosuppression could depend on the concentration of the bacteria and their products in infective foci.
authors.affiliation: Department of Infectious Biology, University of Lodz, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Chmiela
authors.forename: J A
authors.initials: JA
authors.lastname: Lelwala-Guruge
authors.forename: T
authors.initials: T
authors.lastname: Wadström
authors.forename: W
authors.initials: W
authors.lastname: Rudnicka
mesh_terms: D000328:Adult; D002455:Cell Division / Q000276:immunology; D002458:Cell Fractionation; D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D016480:Helicobacter pylori / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D010835:Phytohemagglutinins / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D010835:Phytohemagglutinins