Renal beta-glucuronidase activity is a bioassay of serum testosterone levels in rats.
Alteration in the testosterone levels in experimental animals is reflected by a corresponding change in kidney beta-glucuronidase activity. With a view to use change in renal beta-glucuronidase activity as a bioassay of androgens, the activity of renal beta-glucuronidase and serum testosterone levels were determined following treatment with cisplatin for 3 alternate days. Levels of both renal beta-glucuronidase activity and serum testosterone were significantly decreased in cisplatin-treated rats. It is therefore suggested that kidney beta-glucuronidase activity can be used as a bioassay of androgens.
Malarvizhi
D
D
School of Life Sciences, Pondicherry University, India.
Mathur
P P
PP
D000818:Animals; D001681:Biological Assay; D005966:Glucuronidase / Q000032:analysis*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D005966:Glucuronidase