title: Changes in haemostatic factors and activation products after exercise in healthy subjects with different ages.
abstract: We studied exercise-induced changes in coagulation and fibrinolytic factors and activation products in different age categories. Thirty-eight sedentary males, divided in three age categories (cats I-III; 20-30, 35-45 and 50-60 y) were subjected to a standardized exercise test. Pre-exercise levels (cats I-III resp) of FVII:c (105 +/- 5, 121 +/- 6 and 123 +/- 7% NP), fibrinogen (2.35 +/- 0.12, 2.55 +/- 0.10 and 2.66 +/- 0.09 mg/ml), prothrombin activation fragment F1 + 2 (0.80 +/- 0.10, 0.80 +/- 0.11 and 1.22 +/- 0.16 nM), t-PA (5.2 +/- 0.6, 9.2 +/- 1.0, 8.6 +/- 1.2 ng/ml) and PAI-I (42.8 +/- 7.5, 67.6 +/- 7.6, 62.2 +/- 10.9 ng/ml) showed differences that seemed related to age. Regression analysis revealed associations with anthropometry (FVII:c, fibrinogen, F1+2, t-PA, PAI-1) rather than with age. Exercise-induced changes in coagulation (increase in von Willebrand factor and FVIII:c and a shortening of APTT) and fibrinolytic potential (increase in t-PA and u-PA) were of comparable magnitude for the three age categories. Hardly any change in F1 + 2 (6%) was observed, while thrombin-antithrombin complexes (93%), plasmin-antiplasmin complexes (79%) and D-dimer (77%) almost doubled during maximal exercise. We conclude that anthropometric differences play a more significant role than age on constitutive levels of haemostatic factors in participants up to 60 years of age. The magnitude of exercise-induced changes is comparable in the age categories under study, and simply super-imposed on constitutive (pre-exercise) levels. Clear evidence for prothrombin activation is lacking, but plasmin formation is enhanced during exercise.
authors.affiliation: Department of Medical Physiology and Sports Medicine, Janus Jongbloed Research Centre (JJRC), University of Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van den Burg
authors.forename: J E
authors.initials: JE
authors.lastname: Hospers
authors.forename: M
authors.initials: M
authors.lastname: van Vliet
authors.forename: W L
authors.initials: WL
authors.lastname: Mosterd
authors.forename: B N
authors.initials: BN
authors.lastname: Bouma
authors.forename: I A
authors.initials: IA
authors.lastname: Huisveld
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood*; D000886:Anthropometry; D001779:Blood Coagulation Factors / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005167:Factor VII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011516:Prothrombin / Q000378:metabolism; D012016:Reference Values; D012044:Regression Analysis; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D001779:Blood Coagulation Factors; D010446:Peptide Fragments; D017395:Plasminogen Activator Inhibitor 1; C045879:prothrombin fragment 1.2; D005167:Factor VII; D011516:Prothrombin; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator