Cyclic Cushing's disease in long-term remission with a daily low dose of bromocriptine.
A 56-year-old male patient with cyclic Cushing's disease remained in a state of remission for more than one year with a relatively low dose of bromocriptine (2.5-3.75 mg/day). It has been reported that bromocriptine treatment for cyclic Cushing's disease induces only a transient remission; in the most effective cases, a relatively high dose (40 mg/day) was necessary. In the hypercortisolemic state, plasma adrenocorticotropic hormone (ACTH) and serum cortisol were not suppressed by dexamethasone and did not respond to corticotropin-releasing factor (CRF). An antehypophysectomy was not effective, even though the resected tissue contained ACTH-positive microadenomas. The present observations thus indicate the effectiveness of bromocriptine for some patients with this rare disorder.
Adachi
M
M
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Takayanagi
R
R
Yanase
T
T
Sakai
Y
Y
Ikuyama
S
S
Nakagaki
H
H
Osamura
Y
Y
Sanno
N
N
Nawata
H
H
D000236:Adenoma / Q000473:pathology / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors / Q000097:blood; D001971:Bromocriptine / Q000008:administration & dosage / Q000627:therapeutic use*; D003480:Cushing Syndrome / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000097:blood; D007016:Hypophysectomy; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D012074:Remission Induction / Q000379:methods
D018492:Dopamine Antagonists; D001971:Bromocriptine; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone