title: The inner ear produces a natriuretic hormone.
abstract: Cytoplasmic granules have been demonstrated in epithelial cells from the endolymphatic sac, an extraosseus part of the inner ear located in the posterior cranial fossa. Intravenously infused extracts from endolymphatic sacs in anesthetized rats elicited a potent natriuresis and diuresis without effects on blood pressure, glomerular filtration rate, or lithium clearance. Only a minor kaliuresis was observed. Extracts of dural tissue adjacent to the endolymphatic sacs had no effect. It is concluded that the endolymphatic sac contains as endogenous inhibitor of sodium reabsorption and could be the sensory organ/mediator of "cerebral" natriuresis. Furthermore, this substance, tentatively named saccin, may influence the homeostasis of the inner ear fluids and accordingly play a significant role in the pathogenesis of Mèniére's disease.
authors.affiliation: Department of Medical Anatomy, University of Copenhagen, Panum Institute, Denmark
authors.forename: K
authors.initials: K
authors.lastname: Qvortrup
authors.forename: J
authors.initials: J
authors.lastname: Rostgaard
authors.forename: N H
authors.initials: NH
authors.lastname: Holstein-Rathlou
mesh_terms: D000042:Absorption / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis; D007758:Ear, Inner / Q000378:metabolism*; D004712:Endolymphatic Sac / Q000737:chemistry / Q000648:ultrastructure; D007275:Injections, Intravenous; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D008094:Lithium / Q000493:pharmacokinetics; D008297:Male; D008854:Microscopy, Electron; D009318:Natriuresis; D045283:Natriuretic Agents / Q000378:metabolism*; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D045283:Natriuretic Agents; D014020:Tissue Extracts; D008094:Lithium; D012964:Sodium; D011188:Potassium