HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.
Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3-5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 microM, respectively), but 3-5 were inactive against HIV-1.
McCormick
J L
JL
Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
McKee
T C
TC
Cardellina
J H
JH
Boyd
M R
MR
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D011793:Queensland; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D000998:Antiviral Agents; D010936:Plant Extracts; D011804:Quinolines