Tolypodiol, an antiinflammatory diterpenoid from the cyanobacterium Tolypothrix nodosa.
A new diterpenoid, tolypodiol (1), has been isolated from the terrestrial cyanobacterium Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The monoacetate derivative 2 was prepared. Tolypodiol (1) and its monoacetate derivative 2 show potent antiinflammatory activity in the mouse ear edema assay.
Prinsep
M R
MR
Department of Chemistry, University of Waikato, Hamilton, New Zealand. michele@waikato.ac.nz
Thomson
R A
RA
West
M L
ML
Wylie
B L
BL
D000107:Acetylation; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D003470:Culture Media; D000458:Cyanobacteria / Q000378:metabolism*; D004195:Disease Models, Animal; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005612:Freeze Drying; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000633:toxicity
D000893:Anti-Inflammatory Agents; D003470:Culture Media; D004224:Diterpenes; C102977:tolypodiol; D013755:Tetradecanoylphorbol Acetate