title: Effect of alloxan induced mild insulin dependent diabetes mellitus on rat erythrocyte cytosolic dehydrogenases.
abstract: In order to understand how the red cell of mild insulin dependent diabetes mellitus rat perform the normal physiological function and maintain integrity cytosolic dehydrogenases were assayed. Lactate dehydrogenase produces the cofactor for glycolytic enzymes while glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase produces the coenzymes for oxygen radical scavanging enzymes. Decrease in activity of cytosolic dehydrogenase renders diabetic erythrocyte population more susceptible to oxidant stress.
authors.affiliation: Department of Biochemistry & Home Science, Allahabad University, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: F
authors.initials: F
authors.lastname: Ahmad
authors.forename: M
authors.initials: M
authors.lastname: Suhail
mesh_terms: D000818:Animals; D003600:Cytosol / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D010734:Phosphogluconate Dehydrogenase / Q000097:blood*; D051381:Rats
chemical_list: D007770:L-Lactate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase