title: A novel leptin receptor isoform in rat.
abstract: Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Ob-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region without homology to other Ob-R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob-Ra and Ob-Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob-R gene family.
authors.affiliation: Gifford Laboratories for Diabetes Research, Dallas, TX 75235, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Wang
authors.forename: Y T
authors.initials: YT
authors.lastname: Zhou
authors.forename: C B
authors.initials: CB
authors.lastname: Newgard
authors.forename: R H
authors.initials: RH
authors.lastname: Unger
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine / Q000235:genetics*; D054411:Receptors, Leptin; D017386:Sequence Homology, Amino Acid
chemical_list: D002352:Carrier Proteins; D018076:DNA, Complementary; C515448:LEPR protein, human; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D054411:Receptors, Leptin; C515447:leptin receptor, mouse