Synthesis and inhibitory activities of isochromophilone analogues against gp120-CD4 binding.
Several isochromophilone analogues were synthesized from sclerotiorin (1) by Wittig reactions and aldol condensation reaction. The structures of the products were elucidated from MS, elemental analysis, 1H NMR and 13C NMR spectra, and their inhibitory activities against gp120-CD4 binding were determined.
Sun
X L
XL
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Takayanagi
H
H
Matsuzaki
K
K
Tanaka
H
H
Furuhata
K
K
Omura
S
S
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D015704:CD4 Antigens / Q000187:drug effects / Q000378:metabolism*; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
C101450:5-chloro-3-(3,5-dimethyl-1,3-heptadienyl)-7-hydroxy-7-methyl-8-(ethoxycarbonylmethyliden)-6H-2-benzopyran-6-one; D000998:Antiviral Agents; D001578:Benzopyrans; D015704:CD4 Antigens; D005663:Furans; D015699:HIV Envelope Protein gp120; C085628:isochromophilone I; C101449:sclerotiorin