title: Giant intracranial aneurysms in two sisters: case report.
abstract: BACKGROUND
  It is rare for intracranial aneurysms to present with cranial nerve palsy caused by the space-occupying effect of the lesion. Herein we discuss two sisters with familial intracranial aneurysms, both of whom presented with cranial nerve palsy.
  
  
  METHODS
  Two female siblings presented with ocular movement and facial sensory disturbances caused by the space-occupying effect of giant aneurysms at the cavernous portion of the internal carotid arteries. The aneurysms were located at the identical site in both patients. Proximal occlusion of the internal carotid artery was effective in both cases, resulting in the promotion of thrombosis within the aneurysms in order to reduce their space-occupying effect.
  
  
  CONCLUSIONS
  This is considered to be the first known case of siblings, both suffering from giant internal carotid artery aneurysms.
authors.affiliation: Department of Neurosurgery, Yamaguchi University, School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Yamasita
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: S
authors.initials: S
authors.lastname: Kashiwagi
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000175:diagnosis; D018810:Magnetic Resonance Angiography; D008875:Middle Aged; D011859:Radiography