[Regulation of liver carbohydrate and lipid metabolism by cell volume].
Certain amino acids such as glutamine and proline stimulate liver glycogen synthesis and lipogenesis. This implies cell swelling and leads to the activation of glycogen synthase and acetyl-CoA carboxylase by a common mechanism. This mechanism results from the cell response to swelling and involves a fall in intracellular concentration of chloride ions and an increase in intracellular concentration of glutamate and aspartate. These ions indeed regulate the protein phosphatases that activate glycogen synthase and acetyl-CoA carboxylase.
Hue
L
L
Institut International de Pathologie Cellulaire et Moléculaire (ICP) et Université Catholique de Louvain, Bruxelles, Belgique.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D048429:Cell Size; D006006:Glycogen Synthase / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis*
D008055:Lipids; D008112:Liver Glycogen; D006006:Glycogen Synthase; D000103:Acetyl-CoA Carboxylase
Régulation du métabolisme hépatique des glucides et des lipides par le volume cellulaire.