Amphotericin B infused in 20% lipid emulsion.
Amphotericin B has been associated with multiple adverse effects; however, clinically it may be the best or only drug of choice for certain infections. This antifungal has traditionally been administered in D5W solutions over 4 to 6 hours with pre- and/or post-hydration and other medications to minimize the renal toxicity and other side effects. There have been studies using amphotericin infused in a 20% lipid emulsion with the hope of decreased side effects. By changing the diluent to lipids, the volumes to be infused over shorter periods was a challenge. This article will examine administration protocols of the D5W mixture and the lipids emulsion solution and does not advocate the use of lipid solutions.
Ryan
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Providence Home Infusion, Portland, Oregon, USA.
D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous
D000935:Antifungal Agents; D005217:Fat Emulsions, Intravenous; D000666:Amphotericin B