[The long-term action of low concentrations of aluminum on the central nervous system of white rats and the determination of the potential danger of the action of these concentrations on man].
Influence of aluminum little concentrations on rats CNS was carry out in chronic experiments. The increase of beta1- and beta2-power density in visual and sensomotor cortex, hippocampus and n. caudatus EEG during slow wave sleep has been shown after single intramuscular injection of AlCl3 in doses 50, 5 and 3 mg/kg. Such effect was not observed after single injection of the agent (1 mg/kg) as well as after its chronic (10 day) application. The minimal toxic dose was 400 mg/kg. Obtained data shown significant difference between minimal effective and minimal toxic doses of AlCl3. It allow us to conclude, that aluminum salts have the small danger of human health.
Oganesian
G A
GA
Titkov
E S
ES
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D006801:Humans; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013997:Time Factors
D000535:Aluminum
Izuchenie dlitel'nogo deĭstviia malykh kontsentratsiĭ aliuminiia na tsentral'nuiu nervnuiu sistemu belykh krys i opredelenie potentsial'noĭ opasnosti deĭstviia étikh kontsentratsiĭ na cheloveka.