title: Effect of neuromuscular block on depth of anaesthesia as measured by the auditory evoked response.
abstract: In a double-blind, randomized, controlled, prospective study, we have investigated the effects of vecuronium and laryngoscopy on the auditory evoked response (AER) of the electroencephalogram (EEG) in 40 ASA I and II patients under steady state anaesthesia. After stable anaesthesia had been achieved with 1.0 MAC of isoflurane and nitrous oxide in oxygen, patients were allocated randomly to receive two separate doses of vecuronium 0.05 mg kg-1 or saline. The AER was recorded before and after each dose and then after 20-s laryngoscopy in each group to determine any changes in the early cortical components of the AER waveform (Pa and Nb). There were no statistically significant changes between the vecuronium and saline groups. However, there was a statistically significant increase in mean Pa amplitude of 36% (P = 0.008) and a reduction in mean Nb latency of 6% (P = 0.05) after laryngoscopy in both the paralysed and unparalysed groups, and these changes did not differ significantly between groups. There were correspondingly significant haemodynamic responses to laryngoscopy in both groups. We conclude that neuromuscular block with vecuronium does not affect depth of anaesthesia as measured by the AER in either stimulated or unstimulated patients. In addition, we have demonstrated clearly the arousal effect of laryngoscopy on the AER.
authors.affiliation: Department of Anaesthesia, Northwick Park Hospital, Middlesex.
authors.forename: C E
authors.initials: CE
authors.lastname: Richmond
authors.forename: A
authors.initials: A
authors.lastname: Matson
authors.forename: C
authors.initials: C
authors.lastname: Thornton
authors.forename: C J
authors.initials: CJ
authors.lastname: Doré
authors.forename: D E
authors.initials: DE
authors.lastname: Newton
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000494:pharmacology; D011446:Prospective Studies; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D018685:Anesthetics, Inhalation; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D007530:Isoflurane; D009609:Nitrous Oxide