title: [Terminal myoglobinuric renal failure in lovastatin therapy with pre-existing chronic renal insufficiency].
abstract: Atraumatic rhabdomyolysis with consecutive oliguric renal failure occurred in a 67-year-old man with chronic renal insufficiency in the pre-dialysis phase after four years of therapy with lovastatin without complications. Diuresis remained low after normalization of the muscle enzymes, and the patient required chronic hemodialysis. This case report shows that lovastatin-associated rhabdomyolysis with consecutive myoglobinuric renal failure can be seen also after long-standing lovastatin therapy. In pre-existing renal insufficiency this can lead to earlier requirement of chronic dialysis treatment.
authors.affiliation: 2. Medizinische Abteilung des Allgemeinen Krankenhauses der Stadt Linz.
authors.forename: G
authors.initials: G
authors.lastname: Biesenbach
authors.forename: O
authors.initials: O
authors.lastname: Janko
authors.forename: U
authors.initials: U
authors.lastname: Stuby
authors.forename: J
authors.initials: J
authors.lastname: Zazgornik
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D007677:Kidney Function Tests; D008148:Lovastatin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009212:Myoglobinuria / Q000139:chemically induced*; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D006435:Renal Dialysis
chemical_list: D000924:Anticholesteremic Agents; D008148:Lovastatin
vernacular_title: Terminales myoglobinurisches Nierenversagen unter Lovastatintherapie bei präexistenter chronischer Nierenfunktionsstörung.