Analysis of breast cancer pedigrees using affected sibship methods.
Haplotype-sharing was examined in sets of affected siblings in the Breast Cancer Linkage Consortium pedigrees [Easton et al., 1993], using both identity-by-descent and identity-by-state methods. Linkage of the disease susceptibility locus to markers on chromosome 17 was confirmed. Substantial genetic heterogeneity was found, with more young cases being attributable to the putative gene. No differences were found between breast and ovarian cancer, and there was no evidence against a simple dominant mode of inheritance.
Barrett
J H
JH
Public Health Medicine, University of Leeds, United Kingdom.
Rigby
A S
AS
D017668:Age of Onset; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D009679:Nuclear Family; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree