title: Inhibitory effects of interleukin-1 blockers on corneal fibroblast proliferation.
abstract: The regulation of would healing is one of the most important fields of research in ophthalmology today. Rabbit corneal fibroblast cultures were used to study the effects of interleukin-1 (IL-1) blockers on the proliferation of fibroblasts which is closely related to the wound healing. It was found that IL-1 blockers, such as CK-17, CK-101A, CK-2 and CK-103A, suppress fibroblast proliferation in a concentration-dependent manner. DNA synthesis was significantly inhibited by CK-17 and CK-103A but not by CK-101A and CK1-102. Although the synthesis of mRNA was reduced by all CK-compounds at most concentration tested, the synthesis of protein was only slightly reduced or unaffected. These results indicate that CK-compounds are potent fibroblast inhibitors but not cytolytic agents.
authors.affiliation: Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: S X
authors.initials: SX
authors.lastname: Liu
authors.forename: G C
authors.initials: GC
authors.lastname: Chiou
mesh_terms: D000166:Acridines / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D003315:Cornea / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007097:Imines / Q000378:metabolism / Q000494:pharmacology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011724:Pyridazines / Q000378:metabolism / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D013843:Thiazines / Q000378:metabolism / Q000494:pharmacology
chemical_list: C091705:2-anilino-3-phenyl-1,3-thiazine; D000166:Acridines; D000894:Anti-Inflammatory Agents, Non-Steroidal; C091706:CK 103A; D007097:Imines; D007375:Interleukin-1; D011724:Pyridazines; D013843:Thiazines; C097967:CK 102; D012313:RNA; C091704:CK 17; D004247:DNA