Interactions between acute effect of angiotensin converting enzyme inhibition and salt balance on the renal function and urinary prostanoids. Studies in healthy women.
The acute effects of angiotensin converting enzyme inhibition on the renal function and urinary prostanoids were studied. Healthy women were studied in both sodium depletion (n = 8) and normal balance of sodium and potassium (n = 6). Each woman underwent paired renal functional explorations (by the clearance method during hypotonic polyuria and subsequent antidiuresis) in the absence and in the presence of enalapril. In both experimental conditions enalapril failed to affect urinary prostanoid excretions. Only in the presence of hyperreninemia induced by salt depletion, enalapril was effective in inducing renal tubular effects only partly consistent with a depressed activity of angiotensin-aldosterone system. Specifically, in sodium depletion enalapril treatment promoted a decreasing trend in urinary salt excretion, dependent in turn on selective stimulation of the distal tubule NaCl transport. Furthermore, plasma potassium concentration was reduced despite the concomitant decrease in urinary potassium excretion.
Agnoli
G C
GC
Cattedra di Medicina Interna II, Università di Bologna.
Borgatti
R
R
Cacciari
M
M
Garutti
C
C
Ikonomu
E
E
Lenzi
P
P
Marinelli
M
M
Stipo
L
L
D000328:Adult; D000584:Amiloride / Q000494:pharmacology; D000804:Angiotensin II / Q000502:physiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007010:Hyponatremia / Q000139:chemically induced / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007677:Kidney Function Tests; D011141:Polyuria / Q000139:chemically induced / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis* / Q000652:urine; D012016:Reference Values; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012964:Sodium / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D011453:Prostaglandins; D006852:Hydrochlorothiazide; D000804:Angiotensin II; D004656:Enalapril; D000584:Amiloride; D012964:Sodium; D011188:Potassium