High-level sensitivity of quantitative pp65 cytomegalovirus (CMV) antigenemia assay for diagnosis of CMV disease in AIDS patients and follow-up.
Cytomegalovirus (CMV) antigenemia was evaluated in 174 patients positive for human immunodeficiency virus. Antigenemia could be detected in 96.7% of patients with CMV disease, 76.9% of patients suffering from a relapse of the disease, and 11.4% of asymptomatic patients with CD4 levels of < 100 cells per microliter. No antigenemia was detected in patients with CD4 levels of 250 to 500 cells per microliter. Specificity and the positive predictive value for CMV disease were increased only if more than 5 positive cells per slide were considered. However, CMV disease may also occur in patients with low-grade antigenemia.
Bek
B
B
Division of Cardiopulmonology, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
Boeckh
M
M
Lepenies
J
J
Bieniek
B
B
Arasteh
K
K
Heise
W
W
Deppermann
K M
KM
Bornhöft
G
G
Stöffler-Meilicke
M
M
Schuller
I
I
Höffken
G
G
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000097:blood / Q000276:immunology*; D012680:Sensitivity and Specificity; D014763:Viral Matrix Proteins / Q000097:blood / Q000276:immunology*; D014773:Virology / Q000379:methods* / Q000706:statistics & numerical data
D000956:Antigens, Viral; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa