Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria.
Four of 30 patients with Plasmodium falciparum infection in Bangkok, Thailand, were positive for anti-neutrophil cytoplasmic antibodies by indirect immunofluorescence 1 month after antimalarial therapy. No myeloperoxidase, proteinase 3, lactoferrin, or elastase reactivity was found. Since no evidence of vasculitis was seen in these patients, anti-neutrophil cytoplasmic antibody production in malaria-infected susceptible patients probably represents a secondary response, indicating neutrophil activation.
Wenisch
C
C
Department of Infectious Diseases, Internal Medicine I, University Hospital of Vienna, Austria.
Wenisch
H
H
Bankl
H C
HC
Exner
M
M
Graninger
W
W
Looareesuwan
S
S
Rumpold
H
H
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies