[D-Ala2,D-Leu5]-enkephalin hydrochloride.
The title compound, L-tyrosyl-D-alanyl-glycyl-L-phenyl-alanyl-D-leucine hydrochloride (C29H40N5O7+. Cl-), co-crystallizes with 2-butanone (C4H8O). The structure determination reveals a slightly distorted type I' beta-bend conformation stabilized by one intramolecular hydrogen bond. This conformation is similar to that observed for other [Leu]-enkephalin analogues.
Deschamps
J R
JR
Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, DC 20375, USA. deschamps@lsm.nrl.navy.mil
George
C
C
Flippen-Anderson
J L
JL
D000595:Amino Acid Sequence; D002074:Butanones / Q000737:chemistry; D003460:Crystallization; D018360:Crystallography, X-Ray; D016308:Enkephalin, Leucine-2-Alanine / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011487:Protein Conformation
D002074:Butanones; D016308:Enkephalin, Leucine-2-Alanine; C005222:methylethyl ketone