Structure and mitogenic activities of corn cob heteroxylans.
Various structurally different water-soluble (ws) and water-insoluble (wis) heteroxylans have been tested for mitogenic and co-mitogenic activity and shown to differ in their stimulating potency. The ws arabinoglucuronoxylan (ws-AGX) from corn cobs exhibited the highest potency which was comparable to that of the immunomodulator zymosan, whereas the wis-AGX from corn cobs was inactive. Water-soluble derivatives of wis-AGX as well as hydrolytically modified ws-AGX fractions were prepared and tested for their mitogenic and co-mitogenic activity. The results indicate that the disaccharide side chains present only in ws-AGX might be important for expression of the immunostimulatory activity of this xylan.
Ebringerová
A
A
Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia.
Hromádková
Z
Z
Hríbalová
V
V
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D008934:Mitogens / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014990:Xylans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003313:Zea mays / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D008934:Mitogens; D014990:Xylans