Chelation in metal intoxication. XXXVIII: Effect of structurally different chelating agents in treatment of nickel intoxication in rat.
Some structurally different chelating agents viz. alpha-mercapto-beta-(2-furyl) acrylic acid (MFA), alpha-mercapto-beta-(2-thienyl) acrylic acid (MTA), meso 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercaptopropane-1-sulfonate (DMPS), diethyl dithiocarbamate (DE-DTC), and N-benzyl-D-glucamine dithiocarbamate (NBG-DTC) were evaluated for their efficacy to mobilized nickel and reverse some nickel-induced biochemical alterations in experimental nickel intoxication. MFA, DMSA, and NBG-DTC appear more effective than their corresponding homologs, MTA, DMPS and DE-DTC, respectively, in enhancing urinary and fecal excretion of nickel and lowering tissue burden of nickel in nickel preexposed rats. These, particularly NBG-DTC, appear promising in the treatment of nickel (II) poisoning. However, there seems no definite relationship between the structure of the chelating agents examined and their ability to counteract the effects of nickel.
Tandon
S K
SK
Chemical Toxicology, Industrial Toxicology Research Centre, Lucknow, India.
Singh
S
S
Jain
V K
VK
Prasad
S
S
D000179:Acrylates / Q000494:pharmacology; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology*; D003300:Copper / Q000378:metabolism; D004050:Ditiocarb / Q000031:analogs & derivatives / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008670:Metals / Q000378:metabolism*; D009532:Nickel / Q000633:toxicity*; D051381:Rats; D004113:Succimer / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism
D000179:Acrylates; D000931:Antidotes; D002614:Chelating Agents; D008670:Metals; C029938:nickel sulfate; C015341:2-mercapto-3-furan-2-ylpropenoic acid; D003300:Copper; D009532:Nickel; D004050:Ditiocarb; D004113:Succimer; C039353:dihydroxyethyldithiocarbamate; D015032:Zinc