Measurement of human liver microsomal cytochrome P450 2D6 activity using [O-methyl-14C]dextromethorphan as substrate.
Rodrigues
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AD
Drug Metabolism Department, Abbott Laboratories, Abbott Park, Illinois 60064, USA.
D002250:Carbon Radioisotopes; D019389:Cytochrome P-450 CYP2D6 / Q000032:analysis* / Q000235:genetics / Q000378:metabolism*; D003915:Dextromethorphan / Q000378:metabolism*; D005557:Formaldehyde / Q000032:analysis / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology*; D010641:Phenotype; D011994:Recombinant Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity
D002250:Carbon Radioisotopes; D011994:Recombinant Proteins; D005557:Formaldehyde; D003915:Dextromethorphan; D019389:Cytochrome P-450 CYP2D6