The expression of both amphetamine-conditioned place preference and pentylenetetrazol-conditioned place aversion is attenuated by the NMDA receptor antagonist (+/-)-CPP.
The present study addressed the ability of the NMDA receptor antagonist (+/-)-CPP ((+/-)-3-(2-carboxy-piperazine-4-yl)-propyl-1-phosphonic acid) to block the expression of amphetamine (AMPH)-conditioned place preference (CPP) or pentylenetetrazol (PTZ)-conditioned place aversion (CPA) in male Wistar rats. During a 4-day conditioning period, daily injections of AMPH (1.5 mg/kg, s.c.), PTZ (20 mg/kg, i.p.) and their vehicles were paired with two distinctive compartments of the shuttle box (balanced procedure). Rats pretreated with saline showed significant preference for the AMPH-paired or aversion of PTZ-paired compartments. Pretreatment with (+/-)-CPP (10-30 mg/kg, i.p.) dose-dependently blocked the expression of both CPP and CPA. These data suggest that NMDA receptors are implicated in the expression of conditioned behaviors.
Bespalov AYu
Department of Pharmacology, Pavlov Medical University, St. Petersburg, Russia.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D012931:Social Environment
D018691:Excitatory Amino Acid Antagonists; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; D003913:Dextroamphetamine; D010433:Pentylenetetrazole