title: 15-Hydroxyprostaglandin dehydrogenase.
abstract: Relatively little is known about how 15-PGDH activity is regulated. Changes in 15-PGDH activity have been reported in response to physiological changes brought about by aging, pregnancy, hormonal changes, hypertension and smoking. In addition a large number of drugs have been shown to affect 15-PGDH activity both in vivo and in vitro. The availability of the 15-PGDH cDNA will be a valuable tool for studying how this enzyme is regulated. Isolation of the genomic DNA with its promoter regions has not yet been reported.
authors.affiliation: Division of Medicinal Chemistry and Pharmaceutics, University of Kentucky College of Pharmacy, Lexington 40536-0082, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Ensor
authors.forename: H H
authors.initials: HH
authors.lastname: Tai
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009243:NAD / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D011453:Prostaglandins; D009243:NAD; D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase