title: Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat.
abstract: The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosomotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.
authors.affiliation: Department of Neurological Surgery, University of California, San Francisco, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Richmon
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: F R
authors.initials: FR
authors.lastname: Sharp
authors.forename: L J
authors.initials: LJ
authors.lastname: Noble
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism*; D008353:Mannitol / Q000494:pharmacology; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009997:Osmotic Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000911:Antibodies, Monoclonal; D018840:HSP70 Heat-Shock Proteins; D007074:Immunoglobulin G; D008353:Mannitol