title: Apolipoprotein E genotype in elderly nondemented subjects without senile changes in the brain.
abstract: Only a small minority of elderly subjects can survive with a brain free of senile changes (senile plaques, neurofibrillary tangles, and amyloid angiopathy) beyond the age of 80 years. We demonstrated that an increase of epsilon 2 allele frequency and a decrease of epsilon 4 allele frequency of the apolipoprotein E gene are associated with such brain aging without senile changes.
authors.affiliation: Department of Neurology, Tokyo Medical and Dental University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: N
authors.initials: N
authors.lastname: Suematsu
authors.forename: E
authors.initials: E
authors.lastname: Otomo
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
mesh_terms: D000368:Aged / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D005838:Genotype; D006801:Humans
chemical_list: D001057:Apolipoproteins E