title: Fever from caffeine.
abstract: Since childhood, a 53-year-old women had developed chills, high-grade fever, myalgia, and cephalea after the ingestion of coffee, tea, cola beverages, and some oral "antiflu" compounds. Skin prick tests performed with all the implicated substances were negative. Single-blind oral challenges with both caffeine and theophylline were positive, reproducing exactly the same clinical symptoms and fever. Oral challenge with pentoxifylline was negative. We report a case of caffeine-induced fever in which we have demonstrated cross-reactivity with theophylline, but not with pentoxifylline.
authors.affiliation: Allergology Service, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Daroca
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Reaño
authors.forename: G
authors.initials: G
authors.lastname: Canto
authors.forename: P
authors.initials: P
authors.lastname: Miranda
mesh_terms: D002110:Caffeine / Q000009:adverse effects* / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D013806:Theophylline / Q000276:immunology
chemical_list: D002110:Caffeine; D013806:Theophylline