title: Infrequent detection of lipoarabinomannan antibodies in human immunodeficiency virus-associated mycobacterial disease. Swiss HIV Cohort Study.
abstract: A commercially available test for the serologic diagnosis of tuberculosis was evaluated for its applicability in human immunodeficiency virus (HIV)-positive patients. Antibodies to lipoarabinomannan were detectable in sera from only 9 of 85 HIV-positive patients with a confirmed diagnosis of tuberculosis. Given the low degree of sensitivity of the assay with sera from HIV-infected patients, the study does not support the use of this serologic assay for the diagnosis of tuberculosis in HIV-infected patients.
authors.affiliation: Department of Medicine, Kantonsspital, St. Gallen, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Boggian
authors.forename: W
authors.initials: W
authors.lastname: Fierz
authors.forename: P L
authors.initials: PL
authors.lastname: Vernazza
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial; D016022:Case-Control Studies; D015331:Cohort Studies; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D009164:Mycobacterium Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods / Q000706:statistics & numerical data; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; C050016:lipoarabinomannan