title: Reduced erythrocyte deformability related to activated lipid peroxidation during the early postburn period.
abstract: The role of lipid peroxidation in reduced red cell deformability has been examined after thermal injury of rats (full skin thickness over 15-20 per cent of total body surface). An increased concentration of erythrocyte malonyldialdehyde (MDA) and blood thiobarbituric acid (TBA) reactive product levels during the first 3 days after thermal trauma was established. There was a remarkable decrease in red cell superoxide dismutase (SOD) activity after burns and an increase in glucose-6-phosphate dehydrogenase (G-6-PD) on day 3 postburn. The deformability of erythrocytes was diminished significantly during the first 3 days after burns. There was a significant negative correlation between the deformability and the amount of MDA accumulated in erythrocytes (r = -0.92). Both the accumulation of MDA and the reduction of SOD activity in erythrocytes were suppressed by alpha-tocopherol treatment, which also prevented the decrease in erythrocyte deformability. These results suggest that the activation of the peroxidative process is a possible mechanism for the decreased deformability of erythrocytes during the early stage after thermal injury.
authors.affiliation: Department of Pathophysiology, Medical University, Varna, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Bekyarova
authors.forename: T
authors.initials: T
authors.lastname: Yankova
authors.forename: I
authors.initials: I
authors.lastname: Kozarev
authors.forename: D
authors.initials: D
authors.lastname: Yankov
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000378:metabolism*; D004907:Erythrocyte Deformability / Q000187:drug effects / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013858:Thiobarbiturates / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D013858:Thiobarbiturates; D014810:Vitamin E; D008315:Malondialdehyde; D005954:Glucosephosphate Dehydrogenase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid