title: Possibility of thermosensitive magnetoliposomes as a new agent for electromagnetic induced hyperthermia.
abstract: This study examined a possibility of dextran magnetite (DM)-incorporated thermosensitive liposomes, namely thermosensitive magnetoliposomes (TMs), as a new hyperthermic agent. The temperatures of TM suspensions and cancer tumors injected with TM suspensions were efficiently elevated up to 42 degrees C by electromagnetic induced heating at a frequency of 500 kHz under both in vitro and in vivo conditions. Thus, a possibility of TMs for selective hyperthermia was demonstrated. The temperature rises obtained at various concentrations of TMs suggest that approximately 15 mg Fe/cm3 tumor volume is adequate as a therapeutic dose of TMs for efficient selective hyperthermia.
authors.affiliation: Second Department of Surgery, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Masuko
authors.forename: K
authors.initials: K
authors.lastname: Tazawa
authors.forename: E
authors.initials: E
authors.lastname: Viroonchatapan
authors.forename: S
authors.initials: S
authors.lastname: Takemori
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Fujimaki
authors.forename: H
authors.initials: H
authors.lastname: Nagae
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: I
authors.initials: I
authors.lastname: Horikoshi
mesh_terms: D000818:Animals; D006614:Hindlimb; D006979:Hyperthermia, Induced / Q000379:methods*; D007505:Iron-Dextran Complex; D008081:Liposomes; D009374:Neoplasms, Experimental / Q000628:therapy*; D051381:Rats
chemical_list: D008081:Liposomes; D007505:Iron-Dextran Complex