The TDT reveals linkage and linkage disequilibrium in a rare disease.
We used the TDT as the basis for our analysis of data from Problem 1 of GAW9. Among the 360 marker loci on six chromosomes, we searched for any that might show both linkage and allelic association with the disease. We applied the TDT to each allele at every marker locus and found strong evidence for linkage in two regions: one on chromosome 1, another on chromosome 5.
McGinnis
R E
RE
Department of Genetics, University of Pennsylvania, Philadelphia 19104, USA.
Ewens
W J
WJ
Spielman
R S
RS
D000483:Alleles; D016009:Chi-Square Distribution; D002874:Chromosome Mapping; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family
D005819:Genetic Markers