Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.
Sun
H D
HD
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
Qiu
S X
SX
Lin
L Z
LZ
Wang
Z Y
ZY
Lin
Z W
ZW
Pengsuparp
T
T
Pezzuto
J M
JM
Fong
H H
HH
Cordell
G A
GA
Farnsworth
N R
NR
D002681:China; D054303:HIV Reverse Transcriptase; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D018894:Reverse Transcriptase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; C100860:nigranoic acid; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase