title: Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy.
abstract: We used proton magnetic resonance spectroscopy (1H MRS) for the assessment of focal brain pathology in 22 right-handed children with a diagnosis of intractable temporal lobe epilepsy, and we related this pathology to cognitive dysfunction. Cognitive assessment was based on measurements of verbal IQ, performance IQ, and the Paired Associate Learning subtest of the Wechsler Memory Scale. Five of the 22 children showed no abnormalities of the temporal lobes on 1H MRS, seven showed unilateral pathology, and 10 showed bilateral abnormalities. We found that left-sided pathology is associated with a loss of verbal cognitive functions, whereas right-sided pathology is associated with a loss of nonverbal functions. These findings are consistent with the pattern of lateralization of brain function that has been observed in adults.
authors.affiliation: Radiology and Physics Unit, Institute of Child Health, London, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: E B
authors.initials: EB
authors.lastname: Isaacs
authors.forename: J H
authors.initials: JH
authors.lastname: Cross
authors.forename: A
authors.initials: A
authors.lastname: Connelly
authors.forename: G D
authors.initials: GD
authors.lastname: Jackson
authors.forename: M D
authors.initials: MD
authors.lastname: King
authors.forename: B G
authors.initials: BG
authors.lastname: Neville
authors.forename: F
authors.initials: F
authors.lastname: Vargha-Khadem
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007360:Intelligence; D007807:Language Tests; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008959:Models, Neurological; D009483:Neuropsychological Tests; D010153:Paired-Associate Learning