title: [Central vein thrombosis in younger patients].
abstract: BACKGROUND
  Vein thromboses are not seldom, even in young patients. The pathogenesis of such perfusion disorders is poorly understood-accordingly, it is difficult to choose therapy specific to the causality and appropriate prophylaxis against recurrence.
  
  
  METHODS
  In a retrospective study we analyzed the clinical findings of seven patients under 45 years of age who suffered a retinal vein occlusion in the past two years.
  
  
  RESULTS
  Anatomical changes of the vessels in carotis and ophthalmica regions were not found, as was the case in hemostasis and fibrinolysis, as well. However, all patients reported stress problems in family and occupation. Migraine was often mentioned in the anamnesis. Coldness of the extremities and perfusion disorders in the nailfold capillaries examined under capillary microscopy indicated increased vasospasm.
  
  
  CONCLUSIONS
  Vein thromboses are affections of both the arterial and venous circulation. We hypothesize that dysregulation of vascular tone plays an essential role in the genesis of retinal vein thromboses. Increased vasospasm and the incapacity to reactively dilate are potential mechanisms for such perfusion disorders. When counseling patients and applying medical therapy, such a possible pathogenesis should be taken into consideration.
authors.affiliation: Universitäts-Augenklinik Basel.
authors.forename: J
authors.initials: J
authors.lastname: Messerli
authors.forename: J
authors.initials: J
authors.lastname: Flammer
mesh_terms: D000328:Adult; D002196:Capillaries / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008853:Microscopy; D009262:Nails / Q000098:blood supply; D012169:Retinal Vein / Q000503:physiopathology; D012170:Retinal Vein Occlusion / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D014661:Vasoconstriction / Q000502:physiology
vernacular_title: Zentralvenenthrombosen bei jüngeren Patienten.