title: Direct enzymatic assay of urinary sulfated bile acids to replace serum bilirubin testing for selective screening of neonatal cholestasis.
abstract: Direct enzymatic assay of urinary sulfated bile acids is a sensitive, rapid, minimally invasive, and convenient method of detecting cholestasis in young infants. It may replace measurement of serum direct bilirubin for selective screening for biliary atresia and neonatal hepatitis syndrome at 1 month of age.
authors.affiliation: Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Kasano
authors.forename: Y
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Momoya
authors.forename: T
authors.initials: T
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: D
authors.initials: D
authors.lastname: Abukawa
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Adachi
authors.forename: Y
authors.initials: Y
authors.lastname: Tazuke
mesh_terms: D001647:Bile Acids and Salts / Q000652:urine*; D001656:Biliary Atresia / Q000097:blood / Q000175:diagnosis / Q000652:urine; D001663:Bilirubin / Q000097:blood*; D002779:Cholestasis / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000175:diagnosis / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D012680:Sensitivity and Specificity; D013431:Sulfates / Q000652:urine; D013577:Syndrome
chemical_list: D001647:Bile Acids and Salts; D013431:Sulfates; D001663:Bilirubin