Molecular studies of the aetiology of trisomy 8 in spontaneous abortions and the liveborn population.
We have determined the parental origin in eight cases of constitutional trisomy+ 8. In all four cases of spontaneous abortion, the additional chromosome was maternal in origin and there was evidence for nullichiasmate meiosis I occurring in the genesis of this trisomy. In contrast, all four cases of liveborn trisomy 8 appear to have arisen by a mechanism consistent with the post-zygotic mitotic gain of the additional chromosome.
James
R S
RS
Wessex Regional Genetics Laboratory, Salisbury District Hospital, UK.
Jacobs
P A
PA
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D002875:Chromosomes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009030:Mosaicism / Q000235:genetics; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D014314:Trisomy / Q000235:genetics*