Normal distribution of apolipoprotein E alleles in progressive supranuclear palsy.
Apolipoprotein E (Apo E) genotype is a genetic risk factor influencing the development of Alzheimer's disease (AD). Progressive supranuclear palsy (PSP), like AD, is a dementing illness with neurofibrillary tangles. We determined the frequencies of Apo E alleles in 52 PSP patients and 52 age- and gender-matched controls. The distribution of Apo E allele frequencies and genotypes showed no difference between PSP and controls. Apo E allele status does not influence the development of PSP.
Anouti
A
A
Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314, USA.
Schmidt
K
K
Lyons
K E
KE
Hubble
J P
JP
Schellenberg
G
G
Golbe
L I
LI
Lang
A E
AE
Galvez-Jimenez
N
N
Hershey
L
L
Koller
W C
WC
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013494:Supranuclear Palsy, Progressive / Q000235:genetics*
D001057:Apolipoproteins E