Screening for linkage and association in nuclear families.
We applied linkage analysis with a sib-pair method, which also takes into account information on unaffected siblings, and family-based methods of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identified by association analysis, the sib-pair linkage method failed to detect the disease loci 3 and 4. We therefore determined the data structure and sample size necessary for demonstrating linkage to these loci.
Knapp
M
M
Institute for Medical Statistics, University of Bonn, Germany.
Durner
M
M
Baur
M P
MP
D000483:Alleles; D016009:Chi-Square Distribution; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D009679:Nuclear Family