[G-CSF in patients with lupus-associated neutropenia and infections].
Nine patients with SLE-associated neutropenia and infections received 48 Mio U G-CSF per day s.c. for 2-17 days as an adjunct to antibiotic treatment. Granulopoiesis was normal or hyperplastic in all cases. The mean granulocyte count increased within 2 days from 1.4 per nl to 11.4 per nl. Side-effects were exacerbating CNS symptoms in two patients and a case of leukocytoclastic vasculitis. G-CSF induced constantly a rapid and distinct increase of neutrophil granulocytes in lupus-associated neutropenia patients with normo- or hyperplastic granulopoiesis.
Schwab
U M
UM
2. Medizinische Universitäts-Klinik, Kiel.
Harten
P
P
Zeuner
R A
RA
Külper
M
M
Euler
H H
HH
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007279:Injections, Subcutaneous; D007958:Leukocyte Count / Q000187:drug effects; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*; D008297:Male; D009503:Neutropenia / Q000276:immunology / Q000628:therapy*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009894:Opportunistic Infections / Q000276:immunology / Q000628:therapy*
D016179:Granulocyte Colony-Stimulating Factor
G-CSF bei Patienten mit Lupus-assoziierter Neutropenie und Infektionen.