title: SPET monitoring of perfusion changes in auditory cortex following mono- and multi-frequency stimuli.
abstract: OBJECTIVE
  In order to assess the relationship between auditory cortex perfusion and the frequency of acoustic stimuli, twenty normally-hearing subjects underwent cerebral SPET.
  
  
  METHODS
  In 10 patients a multi-frequency stimulus (250-4000 Hz at 40 dB SL) was delivered, while 10 subjects were stimulated with a 500 Hz pure tone at 40 dB SL. The prestimulation SPET was subtracted from poststimulation study and auditory cortex activation was expressed as percent increments.
  
  
  RESULTS
  Contralateral cortex was the most active area with multi-frequency and monofrequency stimuli as well. A clear demonstration of a tonotopic distribution of acoustic stimuli in the auditory cortex was achieved. In addition, the accessory role played by homolateral acoustic areas was confirmed.
  
  
  CONCLUSIONS
  The results of the present research support the hypothesis that brain SPET may be useful to obtain semi-quantitative reliable information on low frequency auditory level in profoundly deaf patients. This may be achieved comparing the extension of the cortical areas activated by high-intensity multifrequency stimuli.
authors.affiliation: Nuclear Medicine Institute, Policlinico A. Gemelli, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: de Rossi
authors.forename: G
authors.initials: G
authors.lastname: Paludetti
authors.forename: W
authors.initials: W
authors.lastname: di Nardo
authors.forename: M L
authors.initials: ML
authors.lastname: Calcagni
authors.forename: D
authors.initials: D
authors.lastname: di Giuda
authors.forename: G
authors.initials: G
authors.lastname: Almadori
authors.forename: J
authors.initials: J
authors.lastname: Galli
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001301:Audiometry, Pure-Tone; D001303:Auditory Cortex / Q000000981:diagnostic imaging* / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000502:physiology; D012016:Reference Values; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime