title: Effect of radiotherapy and chemoradiotherapy on circulating antioxidant system of human uterine cervical carcinoma.
abstract: Circulating lipid peroxide, antioxidant components and the activities of defense enzymes were estimated in uterine cervical carcinoma patients (before and after radiotherapy and radiotherapy combined chemotherapy) and compared with controls. Some of the antioxidant components such as glutathione, vitamin E and selenium are reduced in cervical cancer. The reduced levels of vitamin E and glutathione were normalized after treatment. Erythrocyte lipid peroxide (E-LPx) and erythrocyte membrane lipid peroxide (EM-LPx) levels were found to be increased in all the stages of uterine cervical carcinoma. The important antioxidant enzymes such as erythrocyte superoxide dismutase (E-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) were found to be decreased in uterine cervical carcinoma. These altered biochemical parameters were reversed to normal, of course with varied degree after different mode of therapy. Significant normalization was observed in Type II chemoradiotherapy.
authors.affiliation: Department of Biochemistry, University of Madras, India.
authors.forename: V
authors.initials: V
authors.lastname: Bhuvarahamurthy
authors.forename: N
authors.initials: N
authors.lastname: Balasubramanian
authors.forename: S
authors.initials: S
authors.lastname: Govindasamy
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008875:Middle Aged; D010088:Oxidoreductases / Q000097:blood; D010544:Peroxidases / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D003520:Cyclophosphamide; D010088:Oxidoreductases; D010544:Peroxidases; D005982:Glutathione Transferase; D005978:Glutathione; D002945:Cisplatin