Augmented baroreflex heart rate gain after moderate-intensity, dynamic exercise.
The occurrence of a sustained vasodilation and hypotension after acute, dynamic exercise suggests that exercise may alter arterial baroreflex mechanisms. Therefore, we assessed systemic hemodynamics, baroreflex regulation of heart rate, and cardiac vagal tone after 60 min of cycling at 60% peak oxygen consumption in 12 healthy, untrained men and women (ages 21-28 yr). We derived sigmoidal carotid-cardiac baroreflex relations by measurement of R-R interval changes induced by ramped, stepwise, R-wave-triggered changes in external neck pressure from 40 to -65 mmHg. We estimated tonic cardiac vagal control with power spectral analysis of R-R interval variability in the respiratory frequency band (0.2-0.3 Hz) during frequency- and tidal volume-controlled breathing. Both mean arterial pressure and total peripheral resistance were reduced postexercise [pressure: from 86 +/- 2 (mean +/- SE) to 81 +/- 2 mmHg; resistance: from 23 +/- 2 to 16 +/- 1 units; both P < 0.05]. Cardiac output was increased postexercise (from 3.9 +/- 0.3 to 5.5 +/- 0.5 l/min, P < 0.05). Both slope and range of the carotid-cardiac baroreflex relation were increased postexercise (slope: from 4.7 +/- 0.7 to 6.1 +/- 0.9 ms/mmHg; range: from 186 +/- 23 to 238 +/- 30 ms, P < 0.05). Respiratory R-R interval variability (cardiac vagal tone) was not changed at any time after exercise, whereas heart rate and plasma norepinephrine levels were elevated. Thus moderate-intensity, dynamic exercise increases heart rate and cardiac output, reduces peripheral vascular resistance, and augments baroreflex responsiveness. Our data suggest that augmented baroreflex heart rate gain restrains rather than contributes to postexercise hypotension, which appears to be mediated predominately by vasodilation.
Halliwill
J R
JR
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Taylor
J A
JA
Hartwig
T D
TD
Eckberg
D L
DL
D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D002339:Carotid Arteries / Q000294:innervation; D004837:Epinephrine / Q000097:blood; D005260:Female; D006321:Heart / Q000502:physiology; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D005082:Physical Exertion; D011311:Pressoreceptors / Q000502:physiology
D009638:Norepinephrine; D004837:Epinephrine