How viral oncogenes make the cell cycle.
Oncogenic viruses provide their host cells with additional growth stimuli, thereby extending their proliferative capacity. This implies that viral oncogenes can override growth-suppressive signals, which control cell-cycle progression in untransformed cells. Viral oncoproteins deregulate cell-cycle control by interfering with receptor-mediated signal transduction pathways and the function of nuclear cell-cycle regulatory proteins. As a consequence of these regulatory interactions, many viral oncogenes induce the expression of cellular genes required for cell-cycle progression, including genes encoding G1 cyclins. Apparently, different oncogenic viruses target different subsets of these cell-cycle regulatory pathways to transform cells.
Jansen-Dürr
P
P
Deutsches Krebsforschungszentrum, Forschungs-schwerpunkt Angewandte Tumorvirologie, Heidelberg, Germany. p.jansen-duerr@dkfz-beidelberg.de
D002453:Cell Cycle; D002455:Cell Division; D002472:Cell Transformation, Viral; D016213:Cyclins / Q000096:biosynthesis; D015967:Gene Expression Regulation, Viral; D018816:Genes, cdc; D009856:Oncogene Proteins, Viral / Q000502:physiology; D009858:Oncogenic Viruses / Q000254:growth & development / Q000502:physiology*; D015398:Signal Transduction
D016213:Cyclins; D009856:Oncogene Proteins, Viral