[The characteristics of T-lymphocyte differentiation in type-1 diabetes mellitus].
Postthymic T-precursors were quantified in patients with diabetes mellitus (DM) varying in forms. The number of pre-T-lymphocytes and auto-rosette-forming cells was found to differ significantly in DM type I patients from that of healthy donors. The count of T-precursors was analyzed with regard of DM duration, pattern, ketoacidosis, diabetic microangiopathy, insulin dose, associated diseases. The findings justify introduction of immunomodulating therapy of DM type I patients with thymic drugs and thymomimetics.
Zhuk
E A
EA
Galenok
V A
VA
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001327:Autoimmune Diseases / Q000097:blood*; D002454:Cell Differentiation; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D012397:Rosette Formation; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000166:cytology*
Ob osobennostiakh differentsirovki T-limfotsitov pri sakharnom diabete I tipa.