title: An early effect of acute plasma volume expansion in humans on serum erythropoietin concentration.
abstract: The effect of acute plasma volume change in humans on serum erythropoietin [EPO]s, plasma active renin [REN] and plasma aldosterone [ALDO] concentrations was examined. Plasma volume (PV) expansion was induced by intravenous infusion of 150 ml (30g) of plasma albumin and 500 ml of physiological saline. The [EPO]s decreased by 14.3% (corrected values for PV expansion) and remained decreased for 5 h. The [REN] was decreased by more than 25% during the day of the experiment and [ALDO] by more than 60%. Only a weak positive correlation was found between [EPO]s and [REN] (r = 0.35; P < 0.05) but a lack of correlation between changes in PV and [EPO]s as well as between [EPO]s and [ALDO] was seen. We postulated that in healthy men an acute PV expansion by 10% to 17.5% would not appear to promote stimulation of EPO synthesis for at least 11 h. Since a weak positive correlation was observed between [EPO]s and [REN] and a lack of correlation between [EPO]s and [ALDO], it would seem that there is no direct link between [REN] and [ALDO] and erythropoietin synthesis in healthy subjects.
authors.affiliation: Department of Sports Medicine, Academy of Physical Education, Krakow, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Szyguła
authors.forename: J
authors.initials: J
authors.lastname: Smitz
authors.forename: J
authors.initials: J
authors.lastname: Roeykens
authors.forename: K
authors.initials: K
authors.lastname: De Meirleir
authors.forename: T
authors.initials: T
authors.lastname: Klausen
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D004921:Erythropoietin / Q000097:blood*; D006801:Humans; D008297:Male; D010953:Plasma Volume / Q000502:physiology*; D012083:Renin / Q000097:blood
chemical_list: D004921:Erythropoietin; D000450:Aldosterone; D012083:Renin