title: Efficacy of linsidomine chlorhydrate, a direct nitric oxide donor, in the treatment of human erectile dysfunction: results of a double-blind cross over trial.
abstract: Recent experimental work has demonstrated that nitric oxide (NO) is the neurotransmitter responsible for cavernous smooth muscle relaxation. Different studies on the performance of the direct NO-donor SIN-1 (linsidomine chlorhydrate) in patients with erectile dysfunction have come to conflicting results. We have performed a double-blind cross over trial in 40 patients with erectile dysfunction of mixed etiology comparing SIN-1, SIN-1 plus the alpha-blocker Urapidil, and prostaglandin E1 (PGE1) in order to determine the effectiveness of SIN-1. PGE1 achieved the best response, the combination of SIN-1 and Urapidil performed slightly, statistically insignificantly poorer with significantly increased side effects. SIN-1 alone performed statistically significantly (p < 0.0068) worse. SIN-1 is not a useful alternative to PGE1. The combination of SIN-1 and Urapidil performs equally as good as PGE1 but cannot be recommended due to intolerable side effects.
authors.affiliation: Department of Urology, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
authors.forename: H E
authors.initials: HE
authors.lastname: Wegner
authors.forename: H H
authors.initials: HH
authors.lastname: Knispel
authors.forename: R
authors.initials: R
authors.lastname: Klän
authors.forename: K
authors.initials: K
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism*; D010409:Penile Diseases / Q000188:drug therapy*; D010410:Penile Erection; D010879:Piperazines / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D014665:Vasodilator Agents; D009569:Nitric Oxide; C002385:linsidomine; C015568:urapidil; D008981:Molsidomine; D000527:Alprostadil