New members of the Bcl-2 family and their protein partners.
Any model of apoptosis must explain the mechanism of action of the Bcl-2 family of proteins. This has proved to be unusually difficult. This review concentrates on some of the newly isolated members of this growing family and attempts to provide an insight into the complexity of interactions through which the Bcl-2 proteins modulate apoptosis.
Farrow
S N
SN
Cell Biology Unit, Glaxo Medicines Research Centre, Stevenage, Hertfordshire, UK.
Brown
R
R
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002454:Cell Differentiation; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D051028:bcl-2-Associated X Protein
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein