[The effect of the mast-cell mediators histamine and prostaglandins on the afferent nerve fibers of the small intestine in the cat].
Histamine was shown to increase afferent impulse activity of the small intestine's mesenteric nerves in a dose-dependent manner, the effect being reduced by antagonists of the H1 and H2 histamine receptors. PG E2 and PC D2 also enhanced the afferent impulse activity. Interaction of antigens with the intestinal mast cells seems to participate in immune response.
Akoev
G N
GN
Filippova
L V
LV
Sherman
N O
NO
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D002927:Cimetidine / Q000494:pharmacology; D002974:Clemastine / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects* / Q000294:innervation*; D008407:Mast Cells / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008643:Mesentery / Q000187:drug effects / Q000294:innervation; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D015230:Prostaglandin D2 / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D018377:Neurotransmitter Agents; D002927:Cimetidine; D006632:Histamine; D002974:Clemastine; D015232:Dinoprostone; D015230:Prostaglandin D2
Vliianie mediatorov tuchnykh kletok gistamina i prostaglandinov na afferentnye nervnye volokna tonkoĭ kishki koshki.