Ex vivo culture systems for hematopoietic cells.
During the past few years, hematopoietic cell culture technologies for transplantation therapies have progressed significantly on several fronts. Advances include the discoveries of the growth factors thrombopoietin and Flt-3 ligand, the development of a variety of bioreactor systems, and results from preliminary clinical trials that demonstrate the efficacy of ex vivo expanded hematopoietic cells for transplantation therapy.
Collins
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Department of Chemical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3120, USA. wmmiller@nwu.edu
Papoutsakis
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Miller
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D001769:Blood; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D016895:Culture Media, Serum-Free; D005285:Fermentation; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology; D006801:Humans
D016895:Culture Media, Serum-Free; D016298:Hematopoietic Cell Growth Factors