Beta-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients.
Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between beta-endorphin (beta-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the beta-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.
Spinazzola
F
F
Azienda Ospedaliera S. Camillo, Forlanini, Spallanzani, Roma.
Barletta
C
C
Demartino
G
G
Martini
F
F
Natili
S
S
Noto
P
P
Ferri
F
F
Tossini
G
G
Visco
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000328:Adult; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008875:Middle Aged; D001615:beta-Endorphin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone