title: Multipin solid-phase synthesis of acyl 2, 3-diaminopropionic acid oligomers.
abstract: A modular approach for the synthesis of sets of diverse organic molecules is described. N-alpha-Fmoc-N-beta-Alloc-D-2,3-diaminopropionic acid (Fmoc-D-Dpr(Alloc)-OH) was prepared in four steps from Boc-D-asparagine and used as a scaffold for attachment of sidechains. Using the Multipin approach, a number of model acyl trimers were rapidly prepared by sequential coupling of Fmoc-D-Dpr(Alloc)-OH and acylation of the beta-amino group with a range of activated carboxylic acids.
authors.affiliation: Chiron Mimotopes Pty Ltd, Clayton, Victoria, Australia.
authors.forename: R M
authors.initials: RM
authors.lastname: Valerio
authors.forename: A M
authors.initials: AM
authors.lastname: Bray
authors.forename: K M
authors.initials: KM
authors.lastname: Stewart
mesh_terms: D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D015091:beta-Alanine; C011757:2,3-diaminopropionic acid