title: Transient cranial neuropathy in prostatic cancer with bone metastases after rhenium-186-HEDP treatment.
abstract: Rhenium-186 (tin) hydroxyethylidene diphosphonate (186Re-HEDP), a bone-seeking radiopharmaceutical, has been successfully used in the treatment of patients with painful bone metastases. Toxicity is usually limited to reversible thrombocytopenia. An infrequent but clinically significant side effect is the occurrence of transient cranial neuropathy. We report on two prostatic cancer patients with metastatic bone cancer. Both patients developed transient cranial neuropathy shortly after treatment with 186Re-HEDP. Transient neuropathy of cranial nerves needs to be distinguished from neurological abnormalities caused by disease progression.
authors.affiliation: Department of Nuclear Medicine, University Hospital Utrecht, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: de Klerk
authors.forename: B A
authors.initials: BA
authors.lastname: Zonnenberg
authors.forename: H G
authors.initials: HG
authors.lastname: Krouwer
authors.forename: G H
authors.initials: GH
authors.lastname: Blijham
authors.forename: A
authors.initials: A
authors.lastname: van Dijk
authors.forename: A D
authors.initials: AD
authors.lastname: van het Schip
authors.forename: J
authors.initials: J
authors.lastname: van Die
authors.forename: P P
authors.initials: PP
authors.lastname: van Rijk
mesh_terms: D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D003389:Cranial Nerve Diseases / Q000209:etiology*; D012968:Etidronic Acid / Q000009:adverse effects / Q000627:therapeutic use; D005930:Glossopharyngeal Nerve / Q000528:radiation effects; D006801:Humans; D007002:Hypoglossal Nerve / Q000528:radiation effects; D008297:Male; D008340:Mandibular Nerve / Q000528:radiation effects; D008875:Middle Aged; D010166:Palliative Care; D011471:Prostatic Neoplasms / Q000473:pathology*; D011868:Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D012211:Rhenium / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011868:Radioisotopes; D012211:Rhenium; D012968:Etidronic Acid