title: Prevention of preatheromatous lesions in sand rats by treatment with a nutritional supplement.
abstract: Sand rats fed a hypercholesterolaemic diet containing 0.01% of the anti-thyroid agent 2-mercapto-1-imidazole develop preatheromatous lesions similar to those found in humans, in addition to obesity and insulin resistance. The effects of a nutritional supplement rich in essential fatty acids and garlic extract (Arterodiet) on the appearance and evolution of the lesions were studied. Treatment with this nutritional supplement significantly decreased circulating triglycerides and low-density lipoprotein (LDL)-cholesterol levels but did not alter plasma insulin or glucose levels. Intra-arterial cholesterol levels were also decreased by the treatment which resulted in a normalisation of the atherosclerotic lesions in these animals.
authors.affiliation: Laboratoire des Régulations des Métabolismes et Nutrition, Université Paul Sabatier, Toulouse, France.
authors.forename: G
authors.initials: G
authors.lastname: Marquié
authors.forename: T
authors.initials: T
authors.lastname: Menouar
authors.forename: M T
authors.initials: MT
authors.lastname: Pieraggi
authors.forename: N
authors.initials: N
authors.lastname: Dousset
authors.forename: N
authors.initials: N
authors.lastname: Bennani
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D001786:Blood Glucose / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D004032:Diet; D005849:Gerbillinae / Q000502:physiology*; D006207:Half-Life; D006728:Hormones / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D006728:Hormones; D007328:Insulin; D014280:Triglycerides