[The immunobiological properties of a corpuscular pertussis vaccine inactivated by gamma irradiation].
As a result of the high-dose gamma-irradiation (50 kGy) of corpuscular pertussis vaccine (CPV), pertussis radiovaccine (PRV) was obtained. Compared with CPV, PRV was shown to possess reduced toxicity and higher protective potency. Its adjuvant properties remained at the initial level, while its leukocytosis-promoting and histamine-sensitizing activities drastically decreased. Moreover, PRV produced less pronounced stimulating effect on the proliferation of hematopoietic stem cells, but, in contrast to CPV, was shown to capable of protecting mice from lethal radiation.
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D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006632:Histamine / Q000031:analogs & derivatives / Q000276:immunology; D007114:Immunization; D007964:Leukocytosis / Q000139:chemically induced; D051379:Mice; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology* / Q000528:radiation effects* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000276:immunology / Q000401:mortality; D011836:Radiation Tolerance / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology / Q000528:radiation effects / Q000633:toxicity
D010567:Pertussis Vaccine; D015164:Vaccines, Inactivated; D006632:Histamine; C027556:histamine phosphate
Immunobiologicheskie svoĭstva korpuskuliarnoĭ kokliushnoĭ vaktsiny, inaktivirovannoĭ gamma-oblucheniem.