Cytotoxic azadirachtin-type limonoids from Melia azedarach.
Four new limonoids, 1-tigloyl-3,20-diacetyl-11-methoxymeliacarpinin, 3-tigloyl-1,20-diacetyl-11-methoxymeliacarpinin, 1-cinnamoyl-3-hydroxy-11-methoxymeliacarpinin, and 1-deoxy-3-methacrylyl-11-methoxymeliacarpinin, together with a known limonoid, 1-cinnamoyl-3-acetyl-11-methoxymeliacarpinin, were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopy.
Takeya
K
K
Department of Natural Medicines, Tokyo University of Pharmacy & Life Science, Japan.
Qiao
Z S
ZS
Hirobe
C
C
Itokawa
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D007306:Insecticides; D007941:Leukemia P388; D036701:Limonins; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D010936:Plant Extracts; D018517:Plant Roots; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D007306:Insecticides; D036701:Limonins; D010936:Plant Extracts; D014315:Triterpenes; C010329:azadirachtin