Molecular cloning of the human rad gene: gene structure and complete nucleotide sequence.
We have isolated and sequenced human genomic DNA clones encoding the Ras-related GTP-binding protein, Rad. The gene spans 3.75 kb and consists of five exons and four introns. Translation initiates from the first of two in-frame methionine residues in the second exon. Several potential transcription cis-elements were revealed throughout the 1.7 kb 5'-flanking region, including 'E box' and CArG binding sites for regulators of transcription in muscle.
Caldwell
J S
JS
Research Division, Joslin Diabetes Center, Boston, MA, USA.
Moyers
J S
JS
Doria
A
A
Reynet
C
C
Kahn
R C
RC
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D005091:Exons; D019204:GTP-Binding Proteins / Q000235:genetics*; D005796:Genes; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D010442:Peptide Chain Initiation, Translational; D018631:ras Proteins
C084355:RRAD protein, human; D019204:GTP-Binding Proteins; D018631:ras Proteins