Types of methicillin-resistant Staphylococcus aureus associated with high mortality in patients with bacteremia.
Forty-seven strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from 47 patients with bacteremia were analyzed by chromosomal DNA digestion pattern using pulsed-field gel electrophoresis and evaluated for serological coagulase type, enterotoxin type, and toxic shock syndrome toxin-1 production. The mortality rate was significantly higher in the older patients (> or = 51 years of age) than in the younger patients (< or = 50 years of age) (50% vs. 4%, p = 0.0007). Methicillin-resistant Staphylococcus aureus strains of serological coagulase type II were more likely to be associated with mortality in older patients than were strains of the other types (p = 0.037).
Nada
T
T
Department of Clinical Laboratory Medicine, Nagoya University Hospital, Japan.
Ichiyama
S
S
Iinuma
Y
Y
Inuzuka
K
K
Washida
H
H
Ohta
M
M
Shimokata
K
K
Kato
N
N
Nakashima
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality*; D001427:Bacterial Toxins; D002648:Child; D002675:Child, Preschool; D003030:Coagulase / Q000378:metabolism; D004768:Enterotoxins / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D015183:Restriction Mapping; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000401:mortality*; D013211:Staphylococcus aureus / Q000145:classification* / Q000378:metabolism; D018089:Superantigens
D001427:Bacterial Toxins; D003030:Coagulase; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C034959:enterotoxin C, staphylococcal