title: Fine structural changes of muscle spindles in the gracile axonal dystrophy mutant mouse.
abstract: Fine structural changes of muscle spindles in the extensor digitorum longus of the gracile axonal dystrophy mutant mouse were studied from 20 to 120 postnatal days. Degenerative nerve endings in muscle spindles were first recognized at 20 postnatal days. The sensory nerve endings were usually swollen with decrease of cell organelles, and the cytoplasm was electron-lucent. At 50 postnatal days, atrophic nerve endings were frequently observed in the narrow spaces between the indented cell membrane of intrafusal muscle cells and the basement membrane. In addition to degenerative and atrophic changes, regenerative axons showing fine sprouts (with or without Schwann cell projections) appeared in the sensory nerve endings at this time. At 80 postnatal days, sensory nerve endings frequently showed dystrophic changes characterized by axonal dilatation with accumulations of neurofilaments, tubulovesicular structures, mitochondria and myelin-like figures. These findings suggest that axonal transport in the sensory nerve endings is impaired in this mutant mouse. Motor nerve endings were usually well preserved and normal structures even at 80 postnatal days. Intrafusal fibrosis, decrease in number of sensory nerve endings and atrophy of intrafusal muscle fibres were clearly recognized by 100 days of age.
authors.affiliation: Department of Pathology, Hiroshima University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takagi
authors.forename: K
authors.initials: K
authors.lastname: Oda
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Kajihara
mesh_terms: D000375:Aging; D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000473:pathology*; D003593:Cytoplasm / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D008854:Microscopy, Electron; D009470:Muscle Spindles / Q000473:pathology*; D009132:Muscles / Q000294:innervation; D009137:Muscular Dystrophy, Animal / Q000473:pathology*; D009410:Nerve Degeneration; D015388:Organelles / Q000473:pathology; D011984:Sensory Receptor Cells / Q000473:pathology