Effects of short-term treatment with the thromboxane synthesis blocker indobufen on pressor and depressor humoral factors in healthy humans.
Twelve healthy subjects were studied after single dose (200 mg p.o.) and 3 days (2 x 200 mg daily p.o.) indobufen treatment. Our findings indicated that in addition to well-known antiaggregant activity, indobufen significantly decreases thromboxane B2 and increases 6-keto-prostaglandin F1 after acute and short-term treatment. The activity of renin-angiotensin-aldosterone system and kallikrein-kinin system did not change significantly after both experimental periods. It seems also unlikely that atrial natriuretic peptide mediates the effects of the drug.
Zacharieva
S
S
Clinical Center of Endocrinology and Gerontology, Sofia, Bulgaria.
Orbetzova
M
M
Tcharaktchiev
D
D
Angelova-Gateva
P
P
Andonova
K
K
D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D013997:Time Factors
D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; D000450:Aldosterone; C020371:indobufen; D012083:Renin