title: Autopsy findings in patients with human immunodeficiency virus infection with emphasis on the risk factor of hemophilia.
abstract: The autopsy findings of 80 human immunodeficiency virus (HIV)-infected adults, who died between 1982-1995, are presented with special emphasis on the risk factor of hemophilia. The study included 23 blood product recipients (hemophiliacs n = 21; non-hemophiliacs n = 2), 34 homosexuals, four intravenous drug abusers, and 19 patients with no known risk factor. Nearly all individuals (93%) showed the late stage of acquired immunodeficiency syndrome (AIDS). Blood product recipients had a significantly lower overall frequency of opportunistic infections (p < 0.05). Homosexuality was associated with the highest overall frequency of opportunistic infections and HIV-associated malignancies, such as Kaposi's sarcoma and malignant non-Hodgkin's lymphoma. Exclusive visceral involvement of Kaposi's sarcoma was frequent, and no decrease of Kaposi's sarcoma was observed during the study period. Pneumocystis infections, atypical mycobacteriosis, and non-Hodgkin's lymphoma showed a significant increase during the last five years (1991-1995) of the observation interval. Opportunistic infections and malignancies were the cause of death in approximately one-half of the patients. In blood product recipients, hepatic failure due to posthepatitic cirrhosis and hemorrhage due to hepatic failure with subsequent coagulopathy and in non-blood product recipients, bacterial bronchopneumonia, and diffuse alveolar damage were additional major causes of death. The data suggest a lower risk for HIV-infected blood product recipients, particularly hemophiliacs, to acquire opportunistic infections and malignant neoplasms.
authors.affiliation: Department of Pathology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Bierhoff
authors.forename: A
authors.initials: A
authors.lastname: Weiss
authors.forename: H K
authors.initials: HK
authors.lastname: Wolf
authors.forename: S
authors.initials: S
authors.lastname: Ewig
authors.forename: J
authors.initials: J
authors.lastname: Rockstroh
authors.forename: U
authors.initials: U
authors.lastname: Pfeifer
mesh_terms: D000328:Adult; D001344:Autopsy; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000473:pathology*; D006467:Hemophilia A / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors