title: Long-term effect of perinatal and postnatal asphyxia on developing human auditory brainstem responses: brainstem impairment.
abstract: Long-term effect of perinatal and postnatal asphyxia on the developing auditory brainstem was investigated in children, particularly those who exhibited residual neurodevelopmental deficits, by analyzing the central components of brainstem auditory evoked responses (BAER). The major abnormalities in the BAER were a reduction of wave V amplitude, followed by a decrease in V/I amplitude ratio, while abnormalities in interpeak intervals were relatively rare. These findings suggest that asphyxia could result in residual neural dysfunction of the brainstem but does not appear to exert any major long-term effect on neuronal transmission. BAER abnormalities occurred more frequently in the children with residual neurodevelopmental deficits than those without these deficits after perinatal asphyxia. The occurrence of BAER abnormalities was related to the duration as well as the degree of asphyxia. No significant difference was found in the abnormalities of the central BAER components between the children after perinatal asphyxia and those after postnatal asphyxia, suggesting that perinatal and postnatal asphyxia exerts a similar long-term effect on the developing central nervous system.
authors.affiliation: Department of Physiology, University of Oxford, England.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Jiang
authors.forename: T S
authors.initials: TS
authors.lastname: Tierney
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000209:etiology*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005865:Gestational Age; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis