Three-component model of oestrogen formation and regulation of intratumoural oestrogen pool in breast neoplasms.
Although a two-component model system (i.e. epithelial and stromal spindle-shaped cells) may explain the regulation of aromatase activity and the location of possible intratumoural sources of oestrogen production in mammary neoplasms, a third component, consisting of lymphocytes and macrophages, may also be considered. Examples are presented, suggesting the importance of a three-component model for a more complete understanding of the regulation of oestrogen production in breast-tumour tissue.
Berstein
L M
LM
Laboratory of Endocrinology, Professor NN Petrov Research Institute of Oncology, St Petersburg, Russia.
Santen
R J
RJ
Santner
S J
SJ
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000378:metabolism; D004967:Estrogens / Q000096:biosynthesis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008954:Models, Biological; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology
D004967:Estrogens