[Characteristics of the effect of microinjections of scopolamine into the rat neostriatum on the realization of a conditioned food reflex with different degrees of reinforcement].
In chronic experiments in 32 male Sprague-Dawley rats on the model of food instrumental reflex (Skinner box) it was shown that the effect of Neostriatal scopolamine microinjections (0.3 mkg) depended on the stage of reflex consolidation. Before the complete reflex consolidation the bilateral microinjections of scopolamine into Nucleus Caudatus produce prolonged inhibition of instrumental reflex. Bilateral Neostriatal microinjections of scopolamine in the same doze had no effect in the case of full consolidation of instrumental reflex. Our results suggest that the cholinergic Neostriatal system is crucially involved in the forming of motor engram of instrumental reaction. In the same time the cholinergic neostriatal system either is not involved in the execution of full consolidate instrumental reactions, or another different forebrain structures patricipate in their realization compensating disturbances of striatal cholinergic function.
Tikhonravov
D L
DL
I.P. Pavlov Institute of Physiology Russian Acad. Sci., St. Petersburg.
Shapovalova
K B
KB
Diubkacheva
T A
TA
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections / Q000295:instrumentation / Q000379:methods; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D017072:Neostriatum; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology*
D018727:Muscarinic Antagonists; D012601:Scopolamine
Osobennosti vliianiia mikroin' 'ektsiĭ skopolamina v neostriatum krys na realizatsiiu pishchevogo uslovnogo refleksa raznoĭ stepeni uprochennosti.