title: APHE-3 and APHE-4, two new pyrazoloisoquinolinone antibiotics produced by Streptoverticillium griseocarneum NCIMB 40447.
authors.affiliation: Departamento de Microbiología y Parasitología, Universidad de Alcalá, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Cruz
authors.forename: M S
authors.initials: MS
authors.lastname: Arias
authors.forename: M E
authors.initials: ME
authors.lastname: Arias
authors.forename: J
authors.initials: J
authors.lastname: Soliveri
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013306:Streptomycetaceae / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D007546:Isoquinolines; D011720:Pyrazoles; C101455:antibiotic APHE 3; C101454:antibiotic APHE 4; C078848:antibiotic APHE 1; C078851:antibiotic APHE 2