title: Coriadienin, the first annonaceous acetogenin with two double bonds isolated from Annona coriaceae.
abstract: A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.
authors.affiliation: Laboratoire de Pharmacognosie et Service de RMN, Faculté de Pharmacie, Châtenay-Malabry, France.
authors.forename: E L
authors.initials: EL
authors.lastname: Meneses da Silva
authors.forename: F
authors.initials: F
authors.lastname: Roblot
authors.forename: J
authors.initials: J
authors.lastname: Mahuteau
authors.forename: A
authors.initials: A
authors.lastname: Cavé
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002522:Chlorocebus aethiops; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C100861:coriadienin