[Determination of moxalactam, aztreonam and imipenem by the perchloric hydroxylamine method].
The reaction of perchloric hydroxylamine was adopted for determination of new beta-lactam antibiotics within monobactam, carbapenem and oxazepam groups. Complexes formed in colour reaction are stable over 2 hours in the case of aztreonam and imipenem, and over 1 hour for moxalactam, statistical analysis proved that both hydroxylamine-perchloric and spectrophotometric methods can be used alternatively.
Pajchel
G
G
Zakład Antybiotyków, Instytut Leków, Warszawa.
Borowiecka
B
B
Chojnowski
W
W
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D001398:Aztreonam / Q000032:analysis* / Q000737:chemistry; D004355:Drug Stability; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000737:chemistry*; D015378:Imipenem / Q000032:analysis* / Q000737:chemistry; D009070:Moxalactam / Q000032:analysis* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D006898:Hydroxylamines; D019811:Hydroxylamine; D015378:Imipenem; D001398:Aztreonam; D009070:Moxalactam
Oznaczanie moksalaktamu, aztreonamu i imipenemu metoda hydroksyloaminowo-nadchloranowa.