A light and electron microscopic study of GluR4-positive cells in human cerebral cortex.
In human cerebral cortex non-pyramidal neurons were densely labelled for the glutamate receptor subunit GluR4, but pyramidal cells only lightly. Some small glial cells were also positive. They were either 'non-activated', with thin processes, or 'activated', with thicker stem processes with irregular outlines due to the presence of surface projections, and containing phagocytosed neuronal debris. GluR4-positive glia are putatively identified as oligodendrocyte precursor-like cells, and have similar light microscopic features to NG2 chondroitin sulphate proteoglycan-positive cells [Levine, J.M.,J. Neurosci., 14 (1994) 4716-4730].
Ong
W Y
WY
Department of Anatomy, National University of Singapore, Singapore.
Garey
L J
LJ
D000328:Adult; D002540:Cerebral Cortex / Q000737:chemistry* / Q000166:cytology; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry / Q000648:ultrastructure; D009836:Oligodendroglia / Q000737:chemistry / Q000648:ultrastructure; D017470:Receptors, Glutamate / Q000032:analysis* / Q000737:chemistry
D017470:Receptors, Glutamate