Vitamin D3 analogues.
The natural form of vitamin D3, 1,25-dihydroxyvitamin D3, modulates epidermal proliferation and differentiation and inhibits immune induction. Calcipotriol (calcipotriene) is a synthetic vitamin D analogue that partially separates the newly identified effects from the classic hypercalcemic effect. Topical treatment with calcipotriene has been shown to be effective, well tolerated, and safe for psoriasis.
Kragballe
K
K
Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark.
D000279:Administration, Cutaneous; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004817:Epidermis / Q000187:drug effects; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology
D003879:Dermatologic Agents; C055085:calcipotriene; D002762:Cholecalciferol; D002117:Calcitriol