title: Panencephalitic Creutzfeldt-Jakob disease. Unusual presentation of magnetic resonance imaging and proton magnetic resonance spectroscopy.
abstract: We present serial magnetic resonance imaging (MRI) scans on a biopsy-verified case of Creutzfeldt-Jakob disease (CJD). The initial MRI scan demonstrated increased T2 signal-intensity within the basal ganglia and thalami. Subsequent MRI scans demonstrated a thin cortex, increased T2 signals diffusely within the white matter including U-fibers, and hypointense T2 signals within the basal ganglia, and thalami. Proton magnetic resonance spectroscopy (1H-MRS) study showed an absence of creatine, choline and N-acetylaspartate signals. By these characteristic findings, serial MRI and MRS studies may be helpful in differentiating CJD from other dementing illnesses.
authors.affiliation: Department of Neurology, Tri-Service General Hospital and National Defence Medical Center, Taipei, Taiwan, R.O.C.
authors.forename: W C
authors.initials: WC
authors.lastname: Shyu
authors.forename: C C
authors.initials: CC
authors.lastname: Lee
authors.forename: Y D
authors.initials: YD
authors.lastname: Hsu
authors.forename: J C
authors.initials: JC
authors.lastname: Lin
authors.forename: J T
authors.initials: JT
authors.lastname: Lee
authors.forename: W H
authors.initials: WH
authors.lastname: Lee
authors.forename: W L
authors.initials: WL
authors.lastname: Tsao
mesh_terms: D001706:Biopsy; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D011522:Protons
chemical_list: D011522:Protons