An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.
Previous reports have indicated abnormalities in the concentrations of metabolites of the tryptophan/kynurenine pathway in the brain in Huntington's disease. These have included an increase in 3-hydroxykynurenine and both increases and decreases in kynurenic acid. The activities of two enzymes involved in the metabolism of these compounds, 3-hydroxykynureninase and kynurenine aminotransferase, have been determined in post mortem brain tissue taken from Huntington's disease patients and control subjects.
Pearson
S J
SJ
Department of Biomedical Science, The University of Sheffield, United Kingdom.
Meldrum
A
A
Reynolds
G P
GP
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D008190:Lyases; D008297:Male; D008875:Middle Aged; D000637:Transaminases / Q000378:metabolism*
D000637:Transaminases; C427605:glutamine - phenylpyruvate transaminase; C021481:kynurenine-oxoglutarate transaminase; D008190:Lyases