title: Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: a case report.
abstract: We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.
authors.affiliation: Istituto di Medicina Interna e Geriatria, Università Cattolica del S. Cuore, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: M
authors.initials: M
authors.lastname: Di Fonso
authors.forename: F
authors.initials: F
authors.lastname: Mormile
authors.forename: D
authors.initials: D
authors.lastname: Quaratino
authors.forename: F
authors.initials: F
authors.lastname: Giuffreda
authors.forename: A
authors.initials: A
authors.lastname: Venuti
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000276:immunology*; D003875:Drug Eruptions / Q000209:etiology; D005100:Expectorants / Q000008:administration & dosage / Q000009:adverse effects*; D005998:Glycine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D007111:Immunity, Cellular; D008297:Male; D012130:Respiratory Hypersensitivity / Q000139:chemically induced; D013440:Sulfides; D013876:Thiophenes
chemical_list: D005100:Expectorants; D013440:Sulfides; D013876:Thiophenes; C035227:stepronin; D005998:Glycine