Granulomatous hepatitis induced by aspirin-kodein analgesics.
Salicylate-kodein is a widely used analgesic agent, particularly in outpatient practice. Salicylates have been incriminated in hepatic injury while kodein may induce biliary spasm. We report here a case of granulomatous hepatitis attributed to prolonged intake of this combination, which has never been reported previously to our knowledge.
Elzouki
A N
AN
Department of Medicine, Malmö University Hospital, University of Lund, Sweden.
Lindgren
S
S
D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D003061:Codeine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D006099:Granuloma / Q000139:chemically induced* / Q000175:diagnosis; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000700:Analgesics; D004338:Drug Combinations; C062889:aspirin, codeine drug combination; D001241:Aspirin; D003061:Codeine