Lung cancer producing interleukin-6.
A patient with complaints of high fever and left shoulder pain was found to have a large mass in the left upper lobe on chest roentgenogram. Laboratory evaluation revealed marked thrombocytosis, hypoalbuminemia, and increased serum concentrations of CRP, fibrinogen and interleukin-6 (IL-6). A transcutaneous biopsy specimen revealed large cell carcinoma. Tumor production of IL-6 was confirmed by immunohistochemical staining with an anti-human IL-6 monoclonal antibody (MH60).
Takeuchi
E
E
Department of Internal Medicine, Toneyama National Hospital, Osaka.
Ito
M
M
Mori
M
M
Yamaguchi
T
T
Nakagawa
M
M
Yokota
S
S
Nishikawa
H
H
Sakuma-Mochizuki
J
J
Hayashi
S
S
Ogura
T
T
D001706:Biopsy; D002097:C-Reactive Protein / Q000378:metabolism; D018287:Carcinoma, Large Cell / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D017809:Fatal Outcome; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography
D015850:Interleukin-6; D005340:Fibrinogen; D002097:C-Reactive Protein