title: Epstein-Barr virus infection associated with interstitial nephritis and chronic fatigue.
abstract: Severe renal disease in the setting of Epstein-Barr virus (EBV) infection is exceedingly rare. We report here the case of a 22-year-old man with acute EBV infection associated with severe interstitial nephritis. The patient developed chronic fatigue and chronic renal failure with a serological profile typical of primary EBV infection. Clinical improvement with anti-EBNA seroconversion occurred after acyclovir therapy. Our patient illustrates that chronic fatigue with major organ dysfunction and a serological profile of primary infection can be seen in chronic EBV infection. In such a case, acyclovir may prove beneficial.
authors.affiliation: Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: López-Navidad
authors.forename: P
authors.initials: P
authors.lastname: Domingo
authors.forename: J C
authors.initials: JC
authors.lastname: López-Talavera
authors.forename: N
authors.initials: N
authors.lastname: Rabella
authors.forename: G
authors.initials: G
authors.lastname: Verger
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir