The effect of KW-4679, an antiallergic drug, on experimental allergic rhinitis in guinea pigs: effects on nasal blockage.
We investigated the effect of KW-4679 (Z-11-(dimethylaminopropyliden)-6,11-dihydrodibenzoxepin-2-a cetic acid hydrochloride), an antiallergic agent, on the nasal blockage induced by antigen challenge into the nostrils of actively sensitized guinea pigs. The change of the nasal cavity volume caused by nasal mucosal swelling after antigen challenge was measured by acoustic rhinometry. Oral administration of KW-4679 (0.01-10 mg/kg) significantly inhibited the decrease in the nasal cavity volume at 10 min, 30 min and 6 hr after antigen challenge. Ketotifen (1-10 mg/kg, p.o.) also inhibited the decrease in the nasal cavity volume after antigen challenge. These results indicate that KW-4679 may be useful for the treatment of allergic rhinitis.
Kaise
T
T
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Ohmori
K
K
Sakakura
Y
Y
Ukai
K
K
D000818:Animals; D003990:Dibenzoxepins / Q000494:pharmacology*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008297:Male; D009296:Nasal Cavity / Q000187:drug effects; D015508:Nasal Obstruction / Q000188:drug therapy*; D000069605:Olopatadine Hydrochloride; D012220:Rhinitis / Q000188:drug therapy*; D013997:Time Factors
D003990:Dibenzoxepins; D000069605:Olopatadine Hydrochloride