Prognostic factors in squamous cell cancer of the vulva and the implications for treatment.
Basic research in vulvar cancer results in new prognostic variables such as human papillomavirus DNA and epidermal growth factor receptor level. It also suggests that p53 mutants are involved in the pathogenesis of this disease. However, histopathological parameters of the lymph nodes, such as capsule breakthrough are the most significant prognosticators for patient survival.
van der Velden
J
J
Department of Gynaecology and Obstetrics, Academic Medical Centre, Amsterdam, The Netherlands.
Hacker
N F
NF
D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006119:Groin / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate; D014846:Vulvar Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy