How is individual risk for prostate cancer assessed?
A man's risk of developing prostate cancer is influenced by both genetic and nongenetic factors. Genetic factors are particularly important at younger ages, and the attributable risk of strong genetic factors could be as high as 43% among men less than 55 years of age; however, only about 9% of all cases may be directly attributable to a family history of prostate cancer. Race appears to be an important determinant of risk; African-American men are at high risk, whereas men of oriental ancestry are at lower risk. The bases of these racial differences remain obscure but may be related to hormonal differences. Modifiable risk factors are most important from a public health perspective. Diet or closely related factors appear to hold the most promise for prevention, although the precise factors are unknown. The strongest evidence indicates that some component of animal fat intake appears to act as a promoter of prostate cancer. Other dietary factors, including vitamin D, vitamin E, and beta-carotene and lycopene, may confer protection, but these require more study. Many but not all studies that have examined long-term effects of vasectomy suggest that this procedure may increase risk of prostate cancer, but whether this association is causal is not established. Occupational factors, smoking, and physical activity level do not appear to be major determinants of prostate cancer risk.
Giovannucci
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Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
D004041:Dietary Fats / Q000009:adverse effects; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D008297:Male; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D044469:Racial Groups / Q000235:genetics; D018570:Risk Assessment; D014659:Vasectomy / Q000009:adverse effects; D014815:Vitamins / Q000097:blood
D004041:Dietary Fats; D012739:Gonadal Steroid Hormones; D014815:Vitamins