Separation of enantiomers of drugs by capillary electrophoresis. III. Beta-cyclodextrin as chiral solvating agent.
Enantiomer separation by capillary zone electrophoresis was studied for a set of 34 chiral drugs. Keeping the concentration of beta-cyclodextrin as a chiral solvating agent as constant as possible led to the separation of seven enantiomeric pairs. Carvedilol, Tetryzoline, Tropicamide and Zopiclone gave a baseline separation, Chlorphenamine, Ketamine, and Orciprenaline a partial separation. Statistical analysis revealed that the best separation factors were observed for a medium degree of interaction with the cyclodextrin. A theory explaining this effect provides a helpful guideline for further optimization.
Koppenhoefer
B
B
University of Tübingen, Germany.
Epperlein
U
U
Christian
B
B
Lin
B
B
Ji
Y
Y
Chen
Y
Y
D053961:Azabicyclo Compounds; D002227:Carbazoles / Q000302:isolation & purification; D000077261:Carvedilol; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002744:Chlorpheniramine / Q000302:isolation & purification; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D007093:Imidazoles / Q000302:isolation & purification; D007202:Indicators and Reagents; D007649:Ketamine / Q000302:isolation & purification; D009921:Metaproterenol / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification*; D010879:Piperazines / Q000302:isolation & purification; D011412:Propanolamines / Q000302:isolation & purification; D013237:Stereoisomerism; D014331:Tropicamide / Q000302:isolation & purification; D047392:beta-Cyclodextrins
D053961:Azabicyclo Compounds; D002227:Carbazoles; D003505:Cyclodextrins; D007093:Imidazoles; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D010879:Piperazines; D011412:Propanolamines; D047392:beta-Cyclodextrins; C515050:zopiclone; D000077261:Carvedilol; D002744:Chlorpheniramine; D009921:Metaproterenol; D007649:Ketamine; C031215:betadex; D014331:Tropicamide; C005810:tetrahydrozoline