title: Novel transcribed sequences represented in the complex genomic region 5q13.
abstract: YACs from the complex repetitive human genomic region 5q13, spanning the spinal muscular atrophy (SMA) locus, have been searched for transcribed sequences using the method of End Ligation Coincident Sequence Cloning. Six transcripts (PT1-6) have been identified, three of which (PT4, PT5 and PT6) are novel. Five of these elements hybridise to multiple loci in 5q13, but PT5 is single copy and maps very close to markers that show linkage disequilibrium with SMA.
authors.affiliation: MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
authors.forename: K E
authors.initials: KE
authors.lastname: Morrison
authors.forename: S J
authors.initials: SJ
authors.lastname: Qureshi
authors.forename: S
authors.initials: S
authors.lastname: Anderson
authors.forename: J P
authors.initials: JP
authors.lastname: Borrett
authors.forename: A
authors.initials: A
authors.lastname: Theodosiou
authors.forename: N
authors.initials: N
authors.lastname: Rodrigues
authors.forename: D
authors.initials: D
authors.lastname: Blake
authors.forename: A
authors.initials: A
authors.lastname: Nesbit
authors.forename: K E
authors.initials: KE
authors.lastname: Davies
authors.forename: D J
authors.initials: DJ
authors.lastname: Porteous
authors.forename: A J
authors.initials: AJ
authors.lastname: Brookes
mesh_terms: D001483:Base Sequence; D018244:Chromosomes, Artificial, Yeast; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003001:Cloning, Molecular; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution; D014158:Transcription, Genetic
chemical_list: D005819:Genetic Markers; D012333:RNA, Messenger