Molecular basis of skeletal muscle regeneration.
Skeletal muscle regeneration is a vital process with important implications for various muscle myopathies and adaptations to physiological overload. Few of the molecular regulatory proteins controlling this process have so far been identified. Several growth factors have defined effects on myogenic precursor cells and appear to also be involved during regeneration. In addition, factors that may be released by cells of the immune system may activate satellite cells during regeneration. Many of these growth factors are associated with signalling cascades which transmit information to the nucleus. The nuclear "receptors" that receive the incoming signals are transcription factors that interact with DNA regulatory sequences in order to modulate gene expression. Of the nuclear factors isolated so far, the immediate-early genes are associated with muscle precursor cell proliferation. This review aims to synthesize the extensive research on myogenic differentiation and relate this to research concerning the molecular regulation of skeletal muscle regeneration.
Chambers
R L
RL
Department of Kinesiology, Faculty of Pure and Applied Science, York University, Toronto, ON.
McDermott
J C
JC
D000222:Adaptation, Physiological / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early / Q000235:genetics; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D009124:Muscle Proteins / Q000235:genetics / Q000502:physiology; D018482:Muscle, Skeletal / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D009135:Muscular Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D012038:Regeneration / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D012045:Regulatory Sequences, Nucleic Acid; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D006133:Growth Substances; D009124:Muscle Proteins; D014157:Transcription Factors; D004247:DNA