Alterations with age of the T3-stimulated release of atrial natriuretic peptide and its effect on water and sodium metabolism in rats.
The influence of age on urinary excretion of sodium and water and in vitro release of atrial natriuretic peptide (ANP) were studied in rats. Older rats had increased daily water intake and urine output. They also had increased plasma ANP, decreased right atrial contents of ANP and increased ANP release in response to 10 nM T3. The ageing process may have altered the regulatory mechanisms of water metabolism and secretion of ANP.
Hwu
C M
CM
Department of Internal Medicine, Veterans General Hospital-Taipei, Taiwan, ROC.
Hwang
C Y
CY
Lau
C P
CP
Tsai
S C
SC
Lee
K Y
KY
Wang
T L
TL
Young
T K
TK
Fang
V S
VS
Ho
L T
LT
Wang
P S
PS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism*; D014284:Triiodothyronine / Q000187:drug effects*
D014284:Triiodothyronine; D009320:Atrial Natriuretic Factor; D012964:Sodium