title: Hyaluronan turnover in the synovial fluid in metacarpophalangeal--and middle carpal joints in standardbred horses.
abstract: The biological turnover of hyaluronan (sodium hyaluronate) of different molecular weights (0.6 x 10(6) and 2.5 x 10(6) Daltons) was studied in the synovial fluid of the middle carpal and metacarpophalangeal joints of 6 clinically healthy Standardbred horses. The hyaluronan was radioactively labelled with 14C. The biological half-life (t1/2) was calculated from repeated synovial samples after injection of the labelled hyaluronan. The mean t1/2 in the metacarpophalangeal joints was 9.7 h for low molecular weight hyaluronan and 8.9 h for high molecular weight hyaluronan and in the middle carpal joints 16.0 h and 12.5 h respectively. These was no significant difference in turnover of the different molecular weights of hyaluronan.
authors.affiliation: Department of Medicine and Surgery, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden. Arne.Lindholm@kirmed.slu.se
authors.forename: A
authors.initials: A
authors.lastname: Lindholm
authors.forename: B
authors.initials: B
authors.lastname: Ronéus
authors.forename: G
authors.initials: G
authors.lastname: Lindblad
authors.forename: B
authors.initials: B
authors.lastname: Jones
mesh_terms: D000818:Animals; D002350:Carpus, Animal; D005260:Female; D006736:Horses; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D008662:Metacarpophalangeal Joint; D008970:Molecular Weight; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D006820:Hyaluronic Acid