title: Collection and transfusion of granulocyte concentrates from donors primed with granulocyte stimulating factor and response of myelosuppressed patients with established infection.
abstract: Fifteen patients with prolonged neutropenia (a median of 23 days with granulocyte [PMN] < or = 500/microliters) and established fungal infections that had not responded to adequate antifungal therapy were transfused with PMN concentrates collected from 35 cytokine-primed granulocyte colony-stimulating factor (GCSF) donors. Patients received a median of six transfusions. Leukocytosis and granulocytosis were observed within 24 hours of the first GCSF injection, which yielded concentrates averaging 55 x 10(9) white blood cells and 41 x 10(9) PMN. Data analysis suggested that response might be related to the duration of neutropenia and known infection, as patients given PMN tx earlier in the infectious course tended to have a better response. No significant toxicity was observed in donors.
authors.affiliation: Department of Hematology, University of Texas, M.D. Anderson Cancer Center, Houston, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Hester
authors.forename: M C
authors.initials: MC
authors.lastname: Dignani
authors.forename: E J
authors.initials: EJ
authors.lastname: Anaissie
authors.forename: H M
authors.initials: HM
authors.lastname: Kantarjian
authors.forename: S
authors.initials: S
authors.lastname: O'Brien
authors.forename: E J
authors.initials: EJ
authors.lastname: Freireich
mesh_terms: D016913:Blood Component Transfusion; D001782:Blood Donors; D001800:Blood Specimen Collection / Q000379:methods*; D001855:Bone Marrow Diseases / Q000209:etiology / Q000628:therapy*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects / Q000637:transplantation*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009181:Mycoses / Q000150:complications*; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor