title: Correlation between colposcopically directed biopsy and cervical loop excision.
abstract: Colposcopy is standard for diagnosis of cervical cancer precursors, but the development of diathermy loop electrodes for excision of the cervical transformation zone offers a technique for validation. Loop excision of the transformation zone was performed for 47 consecutive women with dysplasia in colposcopically directed biopsies using 20 x 8-mm electrodes. Specimens were marked for orientation and serially sectioned. All pathology material was reviewed. Although 28% of women had disappearance of dysplasia at the biopsy site, only 9% had no dysplasia in the transformation zone. Half of the women with CIN 1 on directed biopsy had high-grade lesions found in loop excision specimens. Significant discrepancies may be found between the results of colposcopically directed biopsy and loop excision.
authors.affiliation: Division of Gynecologic Oncology, Cook County Hospital, Chicago, Illinois 60612, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Massad
authors.forename: C J
authors.initials: CJ
authors.lastname: Halperin
authors.forename: P
authors.initials: P
authors.lastname: Bitterman
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods*; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery*; D003127:Colposcopy; D003972:Diathermy; D005260:Female; D006801:Humans; D016634:Radiosurgery; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology