Screening for linkage using a multipoint identity-by-descent method.
The multipoint identity-by-descent method (MIM) was used to analyze simulated data for quantitative traits from GAW9. A two-stage method of implementation was used. First, polymorphic markers spaced 6-12 cM apart were used to identify chromosomes of interest for each trait Q1-Q4; and second, for each of these chromosomes, markers spaced 2 cM apart were used to confirm the linkage detected and refine the region for the susceptibility loci. MIM performed well at both levels of mapping, correctly detecting major genes for trait Q3 on chromosome 2, trait Q2 on chromosome 1, and trait Q4 on chromosome 5.
Lewis
C M
CM
Department of Medical Informatics, University of Utah, Salt Lake City 84108, USA.
Goldgar
D E
DE
D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D005838:Genotype; D006801:Humans; D016014:Linear Models; D009679:Nuclear Family; D011110:Polymorphism, Genetic
D005819:Genetic Markers