Retiform haemangioendothelioma.
A case of retiform haemangioendothelioma (RH), a recently described rare cutaneous low-grade angiosarcoma, is presented. A 75-year-old female had a 3.5 cm cutaneous nodule in her right lower thigh with 10 year preoperative duration. Microscopically, the dermis and subcutis contained a diffuse and infiltrative neoplasm which was characterized by long arborizing blood vessels arranged in a retiform pattern lined by cuboidal and flattened cells, occasional hobnail appearance of endothelial cells, and a prominent small lymphocytic infiltrate. Small solid areas were also found. Neither significant cellular atypia nor mitotic activity was observed. Immunohistochemically, the tumour cells reacted with endothelial markers (CD31, CD34, factor-VIII-related antigen) and bound Ulex europaeus agglutinin 1. There was no pericytic component within the tumour. The tumour was diploid by flow cytometry. The patient had a local recurrence 27 months after the excision. These findings support the view that RH is a low-grade angiosarcoma and indicate that RH must be distinguished from conventional angiosarcoma.
Fukunaga
M
M
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Endo
Y
Y
Masui
F
F
Yoshikawa
T
T
Ishikawa
E
E
Ushigome
S
S
D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006390:Hemangioendothelioma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D037102:Lectins / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D037121:Plant Lectins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor / Q000032:analysis
D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; D015815:Cell Adhesion Molecules; D037102:Lectins; D037121:Plant Lectins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C036850:Ulex europaeus lectins; D014841:von Willebrand Factor