The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping.
The high-affinity receptor for interleukin-11 (IL-11) is composed of two subunits, IL-11 receptor alpha chain (IL-11R alpha) and gp130, the common subunit of the interleukin-6 (IL-6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor, and oncostatin M receptors. The IL-11 receptor-specific alpha chain shares homologies with the alpha chain of the CNTF and IL-6 receptors. We isolated and characterized genomic DNA clones encompassing the entire coding sequence of the IL-11R alpha cDNA. The exon-intron organization of the IL-11R gene (HGMW-approved symbol IL11RA) is consistent with the predicted structure of the different domains of the IL-11R alpha protein, confirming evolutionary conservation at the level of gene organization among the hematopoietic cytokine receptor family. The IL-11R gene has been assigned to chromosome 9 band p13 by in situ hybridization using human IL-11R alpha cDNA as a probe. The fact that the ciliary neurotrophic factor (CNTFR) gene has recently been localized on this same band and the conserved genomic structure between IL-11R and CNTFR suggest that they may have evolved from a common ancestor.
Chérel
M
M
Institut National de la Santé et de la Recherche Médicale (INSERM U211), Nantes, France.
Sorel
M
M
Apiou
F
F
Lebeau
B
B
Dubois
S
S
Jacques
Y
Y
Minvielle
S
S
D001483:Base Sequence; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053703:Interleukin-11 Receptor alpha Subunit; D007438:Introns; D008969:Molecular Sequence Data; D011487:Protein Conformation; D020801:Receptor, Ciliary Neurotrophic Factor; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics*; D053702:Receptors, Interleukin-11; D017475:Receptors, Nerve Growth Factor / Q000235:genetics
D018076:DNA, Complementary; C508428:IL11RA protein, human; D053703:Interleukin-11 Receptor alpha Subunit; D020801:Receptor, Ciliary Neurotrophic Factor; D018123:Receptors, Interleukin; D053702:Receptors, Interleukin-11; D017475:Receptors, Nerve Growth Factor