title: C4 and 21-hydroxylase gene deletions in nasopharyngeal carcinoma among the Chinese.
abstract: Deletions around the C4 and 21-hydroxylase (21-OH) gene region occur among the Chinese, and C4B together with 21-OHA deletion is the most common. This deletion was found to be strongly associated with human leucocyte antigen (HLA) B58 DRB1*0301, particularly with DRB1*0301. The initial observation of a high frequency of this deletion in nasopharyngeal carcinoma (NPC) was secondary to the B58 DR3 association with NPC. A deletion of 21-OHA alone was observed to be associated with HLA B13 DRB1*1501.
authors.affiliation: Department of Microbiology, National University of Singapore, Singapore.
authors.forename: M
authors.initials: M
authors.lastname: Lim
authors.forename: S H
authors.initials: SH
authors.lastname: Chan
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D003181:Complement C4 / Q000235:genetics*; D017353:Gene Deletion; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D013255:Steroid 21-Hydroxylase / Q000235:genetics*
chemical_list: D003181:Complement C4; D006680:HLA Antigens; D013255:Steroid 21-Hydroxylase