Apolipoprotein E genotype in elderly nondemented subjects without senile changes in the brain.
Only a small minority of elderly subjects can survive with a brain free of senile changes (senile plaques, neurofibrillary tangles, and amyloid angiopathy) beyond the age of 80 years. We demonstrated that an increase of epsilon 2 allele frequency and a decrease of epsilon 4 allele frequency of the apolipoprotein E gene are associated with such brain aging without senile changes.
Yamada
M
M
Department of Neurology, Tokyo Medical and Dental University, Japan.
Itoh
Y
Y
Suematsu
N
N
Otomo
E
E
Matsushita
M
M
D000368:Aged / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D005838:Genotype; D006801:Humans
D001057:Apolipoproteins E