Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles.
A novel HLA-Cw*15, B7 haplotype has been found in Caucasians. Molecular cloning studies demonstrate that this haplotype is constituted by the new alleles Cw*15052 and B*0706, which seem to be intermediate steps in the diversification of their respective allelic families. A pathway for the evolution of Cw*15 alleles is proposed.
Sanz
L
L
Department of Immunology, Hospital Puerta de Hierro, Madrid, Spain.
Vilches
C
C
de Pablo
R
R
Bunce
M
M
Moreno
M E
ME
Kreisler
M
M
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods
D006680:HLA Antigens