Capillary electrophoresis of cardiovascular drugs.
This review surveys the use of capillary electrophoresis for the analysis of cardiovascular drugs. Each section presents examples of separations according to the class of the cardiovascular agent. The classes presented are beta-adrenergic antagonists (beta-blockers), acetylcholinesterase inhibitors, angiotensin-converting enzyme inhibitors, dieuretics, alpha-adrenergic antagonists, calcium channel blockers, cardiac glycosides, hypolipidemics (HmG-CoA reductase inhibitors and fibric acid), vasodilators and sodium channel blockers. Examples of the separation modes discussed include capillary electrophoresis, micellar electrokinetic chromatography using many additives (e.g. sodium dodecyl sulfate, cyclodextrins, bile salts, proteins, oligosaccharides) and isotachophoresis.
Nguyen
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Parke-Davis, Pharmaceutical Analytical Research, Morris Plains, NJ 07950, USA.
Siegler
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D000317:Adrenergic alpha-Antagonists / Q000032:analysis; D000319:Adrenergic beta-Antagonists / Q000032:analysis; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis; D002121:Calcium Channel Blockers / Q000032:analysis; D002317:Cardiovascular Agents / Q000032:analysis*; D002800:Cholinesterase Inhibitors / Q000032:analysis; D004232:Diuretics / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D002317:Cardiovascular Agents; D002800:Cholinesterase Inhibitors; D004232:Diuretics