[How to perform and interpret the results of a chemoresistance test of Plasmodium falciparum in malaria patients in a tropical region].
Since the emergence of chemoresistant malaria in Africa at the end of the 1970's, many scientific papers have been published. However, terms used in chemoresistant studies and interpretation of tests are not always appropriate. Based on the usual operative definitions, this paper updates methods of chemoresistance study, interpretation of tests and the course of action to take in case of resistance. Our emphasis is on symptomatic people. We distinguish the clinical response and the parasitological response, two notions which are often confused. A diagram is presented for interpreting the different types of responses of in vivo testing in symptomatic people. For adequate case management of malaria, rigorous analysis of chemoresistant malaria and accurate interpretation of the test results are required.
Guiguemdé
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RT
Organisation de coordination et de coopération pour la lutte contre les Grandes Endémies/Centre Muraz, Centre de référence de la chimiorésistance du paludisme (CRCP), Burkina Faso.
Gbary
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RA
Coulibaly
S O
SO
Ouedraogo
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JB
D000655:Amodiaquine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D015767:Mefloquine / Q000008:administration & dosage / Q000627:therapeutic use; D010616:Phenanthrenes / Q000008:administration & dosage / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use; D011803:Quinine / Q000008:administration & dosage / Q000627:therapeutic use; D013413:Sulfadoxine / Q000008:administration & dosage / Q000627:therapeutic use; D014329:Tropical Climate
D000962:Antimalarials; D004338:Drug Combinations; D010616:Phenanthrenes; D000655:Amodiaquine; C001205:fanasil, pyrimethamine drug combination; C047386:desethylamodiaquine; D013413:Sulfadoxine; D002738:Chloroquine; D011803:Quinine; C023768:halofantrine; D015767:Mefloquine; D011739:Pyrimethamine
Comment réaliser et interpréter les résultants d'une épreuve de chimiorésistance de Plasmodium falciparum chez les sujets malades en zone tropicale.