title: [Demonstration of activity of two potentiated sulfonamides in feces of horses after oral or intravenous administration].
abstract: Both, the oral and intravenous application of two trimethoprim-potentiated sulfonamides induced measurable antibacterial activities in the feces of horses. With regard to the risk of antibiotic-induced alterations of the gastrointestinal flora, the route of application of potentiated sulfonamides seems to be of minor importance. The antibiotics used were Sulfadimethoxine/Trimethoprim (Trafigal 30% ad us. vet.) for oral and Sulfadoxine/Trimethoprim (Borgal 24% ad us. vet., both Hoechst AG, Frankfurt) for intravenous application. As recommended, both drugs were given in a dose of 20 mg per kg bodyweight. The detection method is based on a procedure layed down in German laws for sulfonamide residues in meat-samples and has undergone some modifications for the examination of feces.
authors.affiliation: Medizinischen und Gerichtlichen Veterinärklinik I, Justus-Liebig-Universität Geissen.
authors.forename: K
authors.initials: K
authors.lastname: Fey
authors.forename: R
authors.initials: R
authors.lastname: Weiss
authors.forename: H H
authors.initials: HH
authors.lastname: Sasse
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents; D004064:Digestive System / Q000382:microbiology; D004350:Drug Residues / Q000032:analysis; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005524:Food Technology / Q000331:legislation & jurisprudence; D005858:Germany; D006736:Horses; D007275:Injections, Intravenous; D008460:Meat / Q000592:standards; D013412:Sulfadimethoxine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D013413:Sulfadoxine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013412:Sulfadimethoxine; D013413:Sulfadoxine; D014295:Trimethoprim
vernacular_title: Aktivitätsnachweis zweier potenzierter Sulfonamide in Kotproben von Pferden nach oraler oder intravenöser Verabreichung.