5-HT3 and 5-HT4 receptors in terminal regions of the mesolimbic system.
In this brief review, we present the evidence for the regulation of the mesolimbic dopamine system by 5-HT3 and 5-HT4 receptors. A range of studies show good evidence that 5-HT3 receptor antagonists reduce raised mesolimbic dopamine activity by blocking 5-HT3 receptors in terminal parts of the mesolimbic dopamine system. Few studies have been conducted on the effects of 5-HT4 receptors on dopamine systems. However, it is clear that 5-HT4 receptors are present in relatively high density in areas of the brain that contain dopamine and preliminary studies show that 5-HT4 receptors may regulate the release of this transmitter.
Kilpatrick
G J
GJ
Department of PRPN, Hoffman La Roche, Basel, Switzerland.
Hagan
R M
RM
Gale
J D
JD
D000818:Animals; D001519:Behavior / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*
D011985:Receptors, Serotonin; D012701:Serotonin; D004298:Dopamine