title: Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment.
abstract: Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days. Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.
authors.affiliation: Department of Psychiatry, Medical College of Pennsylvania, Philadelphia, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Coccaro
authors.forename: R J
authors.initials: RJ
authors.lastname: Kavoussi
authors.forename: R L
authors.initials: RL
authors.lastname: Trestman
authors.forename: S M
authors.initials: SM
authors.lastname: Gabriel
authors.forename: T B
authors.initials: TB
authors.lastname: Cooper
authors.forename: L J
authors.initials: LJ
authors.lastname: Siever
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000493:pharmacokinetics; D011388:Prolactin / Q000097:blood*; D012016:Reference Values; D015203:Reproducibility of Results; D017366:Serotonin Receptor Agonists / Q000493:pharmacokinetics
chemical_list: D010879:Piperazines; D017366:Serotonin Receptor Agonists; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone