title: Synthesis and antidepressant evaluation of new hetero[2,1]benzothiazepine derivatives.
abstract: As a part of a research program directed to the discovery of novel antidepressant agents, a series of new hetero[2,1]benzothiazepine derivatives was synthesized. Some of these compounds antagonized the ptosis and motor depression induced by tetrabenazine and were also active in the Porsolt forced swimming test.
authors.affiliation: Instituto de Química Médica, CSIC, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Díaz
authors.forename: S
authors.initials: S
authors.lastname: Vega
authors.forename: M A
authors.initials: MA
authors.lastname: Expósito
authors.forename: C C
authors.initials: CC
authors.lastname: Sánchez Mateo
authors.forename: V
authors.initials: V
authors.lastname: Darias
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
chemical_list: D000929:Antidepressive Agents, Tricyclic; D001552:Benzazepines