SRY-related genes in Xenopus oocytes.
SRY-related genes are known as Sox (Sry-box) genes. Two Sox cDNAs from Xenopus oocytes were analyzed. The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription. The other Sox gene (xSox-11-D) had a deletion of 262 nucleotides at one end of the HMG box in the xSox-11 cDNA. The deletion resulted in a frame-shift and in variations in base pair composition and the length of the trinucleotide repeat in the C-terminal coding region. The amino acid sequence of the C-terminal domain encoded by xSox-II-D was highly basic and might be involved, together with the HMG box, in the binding to DNA.
Miyata
S
S
Department of Chemistry, College of Humanities and Sciences, Nihon University, Tokyo, Japan.
Miyashita
K
K
Hosoyama
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D016678:Genome; D006609:High Mobility Group Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D009865:Oocytes; D055751:SOXC Transcription Factors; D017422:Sequence Analysis, DNA; D051876:Sex-Determining Region Y Protein; D014018:Tissue Distribution; D014157:Transcription Factors; D014158:Transcription, Genetic; D014981:Xenopus / Q000235:genetics*; D029867:Xenopus Proteins
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; D055751:SOXC Transcription Factors; D051876:Sex-Determining Region Y Protein; C490792:Sox11 protein, Xenopus; D014157:Transcription Factors; D029867:Xenopus Proteins