Deficiency of vitamins E and A in cystic fibrosis is independent of pancreatic function and current enzyme and vitamin supplementation.
The aim of this study was to evaluate to what extent serum vitamins A and E cystic fibrosis are affected by the underlying disease, pancreatic sufficiency or insufficiency, meconium ileus, nutritional status, age and treatment (enzyme and vitamin supplementation). Serum vitamin A and E levels were determined by high performance liquid chromatography in 210 cystic fibrosis patients, subdivided according to clinical condition into four subgroups (unsupplemented pancreatic insufficiency, supplemented meconium ileus, pancreatic sufficiency, supplemented pancreatic insufficiency) and compared with 42 control subjects. Vitamin A and E levels were generally lower in cystic fibrosis patients than in controls (P < 0.002 and P < 0.001 respectively). Subjects with pancreatic insufficiency regularly receiving enzyme and vitamin supplementation had significantly lower vitamin A (P < 0.05) and vitamin E (P < 0.01) levels than controls. In subjects with pancreatic sufficiency only vitamin A was significantly lower than in controls (P < 0.01). Vitamin levels were not age-dependent in cystic fibrosis, and no significant correlation with standardized body weight (Z-score) was observed.


CONCLUSIONS
Cystic fibrosis patients show a clear tendency to vitamin A and E deficiency, irrespective of pancreatic function, body weight and standardized supplementation with pancreatic extract and liposoluble vitamins. Since the clinical significance of this deficiency is still not clear, longitudinal studies of cystic fibrosis patients with and without adequate vitamin supplementation are required.
Lancellotti
L
L
Centro Fibrosi Cistica, Ospedale Civile Maggiore, Verona, Italy.
D'Orazio
C
C
Mastella
G
G
Mazzi
G
G
Lippi
U
U
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D010188:Exocrine Pancreatic Insufficiency / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010184:Pancreatic Extracts / Q000008:administration & dosage*; D014801:Vitamin A / Q000008:administration & dosage*; D014802:Vitamin A Deficiency / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D014810:Vitamin E / Q000008:administration & dosage*; D014811:Vitamin E Deficiency / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy
D010184:Pancreatic Extracts; D014801:Vitamin A; D014810:Vitamin E