title: Dietary fibres reduce blood pressure, serum total cholesterol and platelet aggregation in rats.
abstract: The effects of dietary fat and dietary fibres on blood pressure, serum lipids and platelet aggregation in spontaneously hypertensive and Wistar-Kyoto rats have been investigated. The systolic and diastolic blood pressure values were increased with increasing amounts of dietary fat and normalized by dietary fibre supplementation. The greatest reduction in blood pressure was obtained by a combination of reduced dietary fat and supplementary dietary fibre. Addition of dietary fibre when the amount of dietary fat was high or reduction of dietary fat when the amount of dietary fibre was low gave a smaller effect. In both rat strains the decreases in systolic and diastolic blood pressure values after reducing dietary fat and/or increasing dietary fibre were about 10-15 mmHg. Serum total cholesterol and serum HDL-cholesterol concentrations were reduced by reduction of dietary fat or a combination of dietary fat reduction and dietary fibre addition. A combination of dietary fat reduction and dietary fibre addition was the most effective dietary change for reducing serum triacylglycerol concentration and platelet aggregation. The present study demonstrates that in this experimental model it is possible to reduce risk indicators of coronary heart disease significantly by changing dietary habits.
authors.affiliation: Department of Environmental Medicine, Odense University, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Bagger
authors.forename: O
authors.initials: O
authors.lastname: Andersen
authors.forename: J B
authors.initials: JB
authors.lastname: Nielsen
authors.forename: K R
authors.initials: KR
authors.lastname: Ryttig
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000517:prevention & control; D004041:Dietary Fats / Q000009:adverse effects; D004043:Dietary Fiber / Q000008:administration & dosage / Q000494:pharmacology*; D006973:Hypertension / Q000628:therapy; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D011674:Pulse; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D004043:Dietary Fiber; D010975:Platelet Aggregation Inhibitors; D014280:Triglycerides; D002784:Cholesterol