A gene for autosomal dominant late-onset progressive non-syndromic hearing loss, DFNA10, maps to chromosome 6.
Late-onset non-syndromic hearing impairment is the most common type of neurological dysfunction in the elderly. It can be either acquired or inherited, although the relative impact of heredity on this type of loss is not known. To date, nine different genes have been localized, but none has been cloned. Using an extended American family in which a gene for autosomal dominant late-onset non-syndromic hearing impairment is segregating, we have identified a new locus, DFNA10, on chromosome 6.
O'Neill
M E
ME
Department of Otolaryngology, University of Iowa, Iowa City 52242, USA.
Marietta
J
J
Nishimura
D
D
Wayne
S
S
Van Camp
G
G
Van Laer
L
L
Negrini
C
C
Wilcox
E R
ER
Chen
A
A
Fukushima
K
K
Ni
L
L
Sheffield
V C
VC
Smith
R J
RJ
D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005799:Genes, Dominant; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree