title: Epidermal cell proliferative activity assessed by proliferating cell nuclear antigen (PCNA) decreases following immobilization-induced stress in male Syrian hamsters.
abstract: The effects of immobilization-induced stress on epidermal cell proliferative activity, assessed by the proliferating cell nuclear antigen (PCNA) positive ratio, were examined in male Syrian hamsters. In non-stressed animals, PCNA-positive cells were identified frequently in the epidermis in pinna, abdomen, dorsum and scrotum. However, in animals stressed for 4 consecutive days (6 h/day) PCNA-positive cells were significantly reduced in all areas. In stressed animals, the plasma levels of cortisol, corticosterone, epinephrine, and norepinephrine, which are inhibitory to epidermal cells, increased, but plasma testosterone, which is stimulatory to epidermal cells, decreased. The present findings suggest that psychological or physiological stress influences proliferative activity, a fundamental cutaneous function, by inducing changes in the neuroendocrine system.
authors.affiliation: Shiseido Research Center, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: I
authors.initials: I
authors.lastname: Horii
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D006224:Cricetinae; D004848:Epithelium / Q000473:pathology; D006854:Hydrocortisone / Q000097:blood; D007124:Immunoenzyme Techniques; D008297:Male; D008647:Mesocricetus; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications*; D013739:Testosterone / Q000097:blood
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D013739:Testosterone; D003345:Corticosterone; D006854:Hydrocortisone