title: Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy.
abstract: Traditional remedies have been a source of important antimalarial drugs and continue to provide novel and effective treatments, both where pharmaceuticals are not available and where the disease is increasingly resistant to commonly prescribed drugs. The Kenyah of the Apo Kayan, a remote forested plateau in Indonesian Borneo, use 17 malaria remedies derived from natural sources. A quantitative analysis of the relationship between a 'local importance value' index for each malaria remedy (IVmal) and inhibition of cultured Plasmodium falciparum by ethanolic extracts supports the hypothesis that the degree of local consensus about a given remedy is a good indicator of its potential biological efficacy. Our results confirm the rational selection and use of traditional remedies for malaria by the Kenyah. We have identified target species for further research directed toward safe and effective treatments for malaria.
authors.affiliation: Department of Biology, University of Ottawa, Ontario, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Leaman
authors.forename: J T
authors.initials: JT
authors.lastname: Arnason
authors.forename: R
authors.initials: R
authors.lastname: Yusuf
authors.forename: H
authors.initials: H
authors.lastname: Sangat-Roemantyo
authors.forename: H
authors.initials: H
authors.lastname: Soedjito
authors.forename: C K
authors.initials: CK
authors.lastname: Angerhofer
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D001893:Borneo; D007214:Indonesia; D008288:Malaria / Q000188:drug therapy*; D008518:Medicine, East Asian Traditional
chemical_list: D000962:Antimalarials