title: Interleukin-6 (IL-6) in patients with Behçet's disease.
abstract: We have examined the levels of interleukin-6 (IL-6) in plasma and supernatants of peripheral blood mononuclear cells (PBMC) from patients with Behçet's disease and healthy controls using a sensitive enzyme-linked immunosorbent assay (ELISA). Plasma IL-6 level was not detected in any subjects. The IL-6 concentrations in culture supernatants of patients with active Behçet's disease were significantly high compared with patients with inactive disease and healthy controls. Moreover, we investigated IL-6 gene expression in cultured PBMC from patients with Behçet's disease. IL-6 gene expression was enhanced in active patients compared with inactive patients. These results show that IL-6 may play a role in the pathogenesis of Behçet's disease.
authors.affiliation: Department of Dermatology, Yokohama City University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: T
authors.initials: T
authors.lastname: Nagatani
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Yamakawa
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Sekihara
authors.forename: K
authors.initials: K
authors.lastname: Okuda
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D001483:Base Sequence; D001528:Behcet Syndrome / Q000097:blood / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
chemical_list: D015850:Interleukin-6