Glycosaminoglycans in urine and extracorporeal shock wave lithotripsy.
In 50 calcium oxalate stone-forming patients, the total excretion of glycosaminoglycans (GAGs) and of four subgroups [chondroitin-4-sulfate (CS-A), chondroitin-6-sulfate (CS-C), dermatan sulfate (DS) and hyaluronic acid (HY)] were investigated before extracorporeal shock wave lithotripsy (ESWL) and during the subsequent 5 days. The standard value was determined by reference to a group of healthy test subjects. The excretion of GAGs was significantly higher in healthy test persons than in stone-forming patients. Twenty-four hours after ESWL administration, GAG excretion was enhanced significantly but returned to normal values over the course of 3 days. ESWL had no influence on the proportional composition of GAG subgroups CS-A, CS-C, DS and HY. The increase in GAG excretion after ESWL indicates a transient injury of renal tissue or of the mucus layer lining the urothelium. This lesion, however, can be regarded as temporary with later restitutio ad integrum.
Winter
P
P
Department of Urology, University of Bonn, Germany.
Ganter
K
K
Leppin
U
U
Schoeneich
G
G
Hesse
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002129:Calcium Oxalate / Q000378:metabolism; D002807:Chondroitin / Q000378:metabolism; D002809:Chondroitin Sulfates / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D003871:Dermatan Sulfate / Q000378:metabolism; D004848:Epithelium / Q000293:injuries / Q000378:metabolism; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000293:injuries / Q000378:metabolism; D007669:Kidney Calculi / Q000378:metabolism / Q000628:therapy; D008096:Lithotripsy; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011237:Predictive Value of Tests; D012737:Sex Factors
D006025:Glycosaminoglycans; D003871:Dermatan Sulfate; D002129:Calcium Oxalate; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates; D003404:Creatinine