Mechanisms of carcinogenesis and the mutant mouse.
Gene targeting in embryonic stem cells has allowed the creation of several new mouse strains carrying mutations in the murine homologs of human tumor suppressor genes. The phenotypes of these mutant strains are reviewed. In addition, recent experiments utilizing the ApcMin and p53 mutant animals to address specific mechanisms of carcinogenesis are discussed.
Williams
B O
BO
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA. bowillia@athena.mit.edu
Jacks
T
T
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000818:Animals; D015197:Carcinogenicity Tests; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D007414:Intestinal Neoplasms / Q000209:etiology / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D009374:Neoplasms, Experimental; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53