title: Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits.
abstract: Field stimulation relaxed the sphincter of Oddi muscle rings of the rabbit after incubation with phentolamine, oxprenolol and atropine (all 1 microM). The relaxation was blocked by NG-nitro-L-arginine methyl ester (30 microM) and was reversed by 3 mM L-arginine but not D-arginine. Sphincter of Oddi preparations from hypercholesterolaemic rabbits exhibited contractions under the same conditions. We conclude that nitrergic relaxation is impaired in the sphincter of Oddi from hypercholesterolaemic rabbits.
authors.affiliation: First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Szilvassy
authors.forename: I
authors.initials: I
authors.lastname: Nagy
authors.forename: J
authors.initials: J
authors.lastname: Szilvassy
authors.forename: I
authors.initials: I
authors.lastname: Jakab
authors.forename: S
authors.initials: S
authors.lastname: Csati
authors.forename: J
authors.initials: J
authors.lastname: Lonovics
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000494:pharmacology; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D011817:Rabbits; D009803:Sphincter of Oddi / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D002791:Cholesterol, Dietary; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester