title: Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles.
abstract: A novel HLA-Cw*15, B7 haplotype has been found in Caucasians. Molecular cloning studies demonstrate that this haplotype is constituted by the new alleles Cw*15052 and B*0706, which seem to be intermediate steps in the diversification of their respective allelic families. A pathway for the evolution of Cw*15 alleles is proposed.
authors.affiliation: Department of Immunology, Hospital Puerta de Hierro, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Sanz
authors.forename: C
authors.initials: C
authors.lastname: Vilches
authors.forename: R
authors.initials: R
authors.lastname: de Pablo
authors.forename: M
authors.initials: M
authors.lastname: Bunce
authors.forename: M E
authors.initials: ME
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Kreisler
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D006680:HLA Antigens