Individual and combined effects of triptoreline and gestrinone on experimental endometriosis in rats.
OBJECTIVE
To evaluate the effects of triptoreline, gestrinone, and both, on experimental endometriosis in rats.


METHODS
Experimental endometriosis was surgically induced in 225 Wistar rats. Of these, 202 rats showed at least one grown implant, 22 of which composed the control group, while 180 were treated with triptoreline, gestrinone, or both, for 28 days. The implants were evaluated again after 25 days.


RESULTS
There were no changes in size in the control group. About 73% of the implants treated with triptoreline showed a high reduction (> 50%), vs. 51% with gestrinone (P < 0.0005) and 65% with both (P < 0.005). Triptoreline caused macroscopic resolution in 40% of the implants vs. 31% for gestrinone (not significant) and 26% for both substances (P < 0.05). In the triptoreline group, the mean size of the implants decreased by 65% between the 25th and 28th days, 58% between the 29th and the 35th, and 39% after the 36th day. This reduction was 51%, 36%, and 33%, respectively, in gestrinone group.


CONCLUSIONS
Triptoreline was more effective than gestrinone, but perhaps not in the long run. Their association did not improve the results.
Quereda
F
F
Department of Obstetrics and Gynecology, School of Medicine, University of Alicante, Spain.
Barroso
J
J
Acién
P
P
D000818:Animals; D004359:Drug Therapy, Combination; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000473:pathology / Q000637:transplantation; D005260:Female; D005867:Gestrinone / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D005867:Gestrinone