Characterization of [3H]GR 113808 binding to 5-HT4 receptors in brain tissues from patients with neurodegenerative disorders.
[3H]GR 113808 binding studies in guinea-pig brain tissue revealed a temperature dependency and pharmacological specificity consistent with labelling of a 5-HT4 receptor. Detailed comparison of competition data between brain regions from human and guinea-pig suggest minor differences in the rank order of affinity. Studies in brain tissue from patients with Alzheimer's Huntington's and Parkinson's disease have revealed specific deficits in 5-HT4 receptor densities.
Wong
E H
EH
Institute of Pharmacology, Syntex Discovery Research, Palo Alto, CA 94022, USA.
Reynolds
G P
GP
Bonhaus
D W
DW
Hsu
S
S
Eglen
R M
RM
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D009422:Nervous System Diseases / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000493:pharmacokinetics*
D007211:Indoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013449:Sulfonamides; C082871:GR 113808