title: Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?
authors.affiliation: Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Christians
authors.forename: J S
authors.initials: JS
authors.lastname: Bleck
authors.forename: A
authors.initials: A
authors.lastname: Lampen
authors.forename: A
authors.initials: A
authors.lastname: Bader
authors.forename: C
authors.initials: C
authors.lastname: Thiesemann
authors.forename: V
authors.initials: V
authors.lastname: Kliem
authors.forename: H
authors.initials: H
authors.lastname: Repp
authors.forename: M
authors.initials: M
authors.lastname: Westhoff-Bleck
authors.forename: M
authors.initials: M
authors.lastname: Manns
authors.forename: K F
authors.initials: KF
authors.lastname: Sewing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D016572:Cyclosporine / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology*; D004386:Duodenum; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000201:enzymology*; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008657:Metabolic Clearance Rate; D008861:Microsomes / Q000201:enzymology; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D012727:Sex Characteristics
chemical_list: D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019392:Cytochrome P-450 CYP2E1; D004110:Diltiazem