Coating of cardiovascular stents with a semiconductor to improve their hemocompatibility.
Thrombogenesis on artificial surfaces can be described as an electron transfer reaction. To inhibit this oxidation process and thereby achieve high hemocompatibility, a surface requires semiconducting properties. However, because all known solid semiconductors are extremely brittle, the requirements for high hemocompatibility and mechanical stability cannot be met by any single material. Therefore, a hybrid design is introduced as a new approach to improve the hemocompatibility of cardiovascular stents.
Bolz
A
A
Department of Biomedical Engineering, Friedrich-Alexander University, Erlangen-Nürnberg, Germany.
Amon
M
M
Ozbek
C
C
Heublein
B
B
Schaldach
M
M
D000792:Angiography; D000818:Animals; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009152:Mutagenicity Tests; D012666:Semiconductors / Q000639:trends; D015607:Stents / Q000009:adverse effects*; D013552:Swine; D013927:Thrombosis / Q000517:prevention & control*