Functional studies of intestinal mast cells in children with food intolerance.
The aim of this study was to characterize some functional properties of intestine mast cells taken from children with food intolerance. The cells were obtained from tissue specimens by the use of the enzymatic method and the sensitivity of mast cells to anti-IgE, substance P (SP) and vasoactive intestinal peptide (VIP) was studied in vitro. We have noticed that (1) mast cells were sensitive to the action of anti-IgE, but there was no correlation with total IgE level, (2) although mast cells were challenged with SP and VIP histamine release was low.
Wasowska-Królikowska
K
K
Second Department of Pediatrics, Medical Academy of Lódź.
Brzezińska-Błaszczyk
E
E
Mińcikiewicz
M
M
Toporowska-Kowalska
E
E
Bodalski
J
J
D002648:Child; D002675:Child, Preschool; D005512:Food Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E; D007223:Infant; D007421:Intestine, Small / Q000166:cytology*; D008407:Mast Cells / Q000276:immunology / Q000502:physiology*; D013373:Substance P; D014660:Vasoactive Intestinal Peptide
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D007073:Immunoglobulin E