Distribution of trigeminothalamic and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity in the rat.
Trigeminothalamic and spinothalamic-tract neurons provided with substance P receptor (SPR) were examined in the rat by SPR immunofluorescence histochemistry combined with Fluoro-Gold (FG) fluorescent retrograde labeling. After FG injection in the thalamic regions, FG-labeled cells with SPR-like immunoreactivity were seen mainly in laminae I and III of the medullary and spinal dorsal horns and lateral spinal nucleus. In these regions, about one-fourth to one-third of FG-labeled cells showed SPR-like immunoreactivity.
Li
J L
JL
Department of Morphological Brain Science, Faculty of Medicine, Kyoto University, Japan.
Ding
Y Q
YQ
Shigemoto
R
R
Mizuno
N
N
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005455:Fluorescent Antibody Technique; D005456:Fluorescent Dyes; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1 / Q000032:analysis*; D013133:Spinothalamic Tracts / Q000737:chemistry* / Q000166:cytology; D013266:Stilbamidines; D013788:Thalamus / Q000737:chemistry* / Q000166:cytology; D012668:Trigeminal Ganglion / Q000737:chemistry* / Q000166:cytology
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D018040:Receptors, Neurokinin-1; D013266:Stilbamidines