Principles of neuronal regeneration.
Studies of retrograde changes in axotomized motoneurons have revealed fundamental changes in morphology, metabolism and physiology of these cells. Restructuring of the granular endoplasmic reticulum, s.c. chromatolysis, seems to be the basis for increased and modified protein synthesis. While cytoskeletal proteins with the exception of the neurofilament triplet go up, enzymes and receptors related to neurotransmission go down and new growth associated proteins appear. There is an enhanced glucose uptake and iron metabolism. Complex changes in axonal transport have been observed. This may reflect the efforts of the regenerating nerve cell to compensate for its lost axon.
Kreutzberg
G W
GW
Department of Neuromorphology, Max-Planck-Institute of Psychiatry, Martinsried, Federal Republic of Germany.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics / Q000502:physiology; D005154:Facial Nerve / Q000473:pathology; D017781:Genes, Immediate-Early / Q000502:physiology; D009046:Motor Neurons / Q000473:pathology*; D009416:Nerve Regeneration / Q000235:genetics*; D017978:Receptors, Growth Factor / Q000235:genetics; D012183:Retrograde Degeneration / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D017978:Receptors, Growth Factor; D015740:Calcitonin Gene-Related Peptide