Lipid peroxidation in hepatocellular carcinoma.
In this study, we measured free radicals and thiobarbituric acid-reactive substances (TBARS) in hepatocellular carcinoma and in non-cancerous liver parenchyma. There was a higher concentration of free radicals in malignant tissue than in non-cancerous tissue. In contrast, the level of TBARS was significantly (P < 0.01) lower than non-cancerous liver parenchyma. These paradoxical results suggested that antioxidative enzyme activity and/or inhibition of lipid peroxidation were higher in hepatocellular carcinoma.
Iwagaki
H
H
First Department of Surgery, Okayama University Medical School, Japan.
Hamazaki
K
K
Matsubara
N
N
Hiramatsu
M
M
Orita
K
K
Mori
A
A
D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
D016166:Free Radical Scavengers; D017392:Thiobarbituric Acid Reactive Substances