title: Characterization of [3H]GR 113808 binding to 5-HT4 receptors in brain tissues from patients with neurodegenerative disorders.
abstract: [3H]GR 113808 binding studies in guinea-pig brain tissue revealed a temperature dependency and pharmacological specificity consistent with labelling of a 5-HT4 receptor. Detailed comparison of competition data between brain regions from human and guinea-pig suggest minor differences in the rank order of affinity. Studies in brain tissue from patients with Alzheimer's Huntington's and Parkinson's disease have revealed specific deficits in 5-HT4 receptor densities.
authors.affiliation: Institute of Pharmacology, Syntex Discovery Research, Palo Alto, CA 94022, USA.
authors.forename: E H
authors.initials: EH
authors.lastname: Wong
authors.forename: G P
authors.initials: GP
authors.lastname: Reynolds
authors.forename: D W
authors.initials: DW
authors.lastname: Bonhaus
authors.forename: S
authors.initials: S
authors.lastname: Hsu
authors.forename: R M
authors.initials: RM
authors.lastname: Eglen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D009422:Nervous System Diseases / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*; D013449:Sulfonamides / Q000493:pharmacokinetics*
chemical_list: D007211:Indoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013449:Sulfonamides; C082871:GR 113808