Day-to-day intraindividual reliability and interindividual differences in monoamines excretion.
The urine of 44 normal men was collected during 2 nights to evaluate components of biological variation, i.e., intraindividual day-to-day variability and interindividual variability in monoamines excretion. Monoamines presented important interindividual variability [interindividual coefficients of variation (%): dopamine 18.3, norepinephrine 66.7, epinephrine 85.3, normetanephrine 22.4, metanephrine 76.8, 3-methoxy-4-hydroxyphenylglycol (MHPG) 77.0, vanilmandelic acid (VMA) 64.3, homovanilic acid (HVA) 71.3, 5-hydroxyindolacetic acid (5-HIAA) 20.4]. The reliability of these amounts was high, with intraclass correlation coefficients ranging from 0.43 (P < 0.001) for MHPG free form to 0.65 (P < 10(-6)) for dopamine and normetanephrine (intraindividual coefficients of variation (%): dopamine 8.5, norepinephrine 39.9, epinephrine 45.9, normetanephrine 10.3, metanephrine 46.3, MHPG 37.5, VMA 30.7, HVA 41.0, 5-HIAA 12.3).
Curtin
F
F
Department of Psychiatry, Geneva University, IUPG, Switzerland.
Walker
J P
JP
Schulz
P
P
D000328:Adult; D002985:Clinical Protocols; D004298:Dopamine / Q000652:urine*; D004837:Epinephrine / Q000652:urine*; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D009638:Norepinephrine / Q000652:urine*; D009647:Normetanephrine / Q000652:urine*; D015203:Reproducibility of Results; D014642:Vanilmandelic Acid / Q000652:urine*
D009647:Normetanephrine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine