title: Lymphocyte subset counts during the course of community-acquired pneumonia: evolution according to age, human immunodeficiency virus status, and etiologic microorganisms.
abstract: We investigated the evolution of lymphocyte subsets in blood samples from 94 consecutive patients with community-acquired pneumonia; these samples were obtained 72 hours after hospitalization and at follow-up, when the patients were considered to be cured. Acute-phase lymphocyte counts, as compared with follow-up counts, were decreased in the overall population (P < .0001); however, the percentage of CD4+ T cells remained unchanged during the course of pneumonia in each patient. These changes that were noted for the overall population were not significantly influenced by age, the presence (or not) of infection with human immunodeficiency virus (HIV), or etiologic microorganisms. Of the 68 HIV-seronegative patients, 12 had initial CD4+ T cell counts of < 200/mm3; multivariate analysis revealed that this finding was significantly associated with the presence of an underlying disease or tuberculosis and an age of > or = 60 years.
authors.affiliation: Service de Médecine Interne, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Fantin
authors.forename: V
authors.initials: V
authors.lastname: Joly
authors.forename: C
authors.initials: C
authors.lastname: Elbim
authors.forename: J L
authors.initials: JL
authors.lastname: Golmard
authors.forename: M A
authors.initials: MA
authors.lastname: Gougerot-Pocidalo
authors.forename: P
authors.initials: P
authors.lastname: Yeni
authors.forename: C
authors.initials: C
authors.lastname: Carbon
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000367:Age Factors; D000368:Aged; D001402:B-Lymphocytes / Q000166:cytology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D002690:Chlamydia Infections / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification; D015331:Cohort Studies; D017714:Community-Acquired Infections / Q000276:immunology; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D018023:HIV Seronegativity; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology; D007877:Legionnaires' Disease / Q000276:immunology; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology*; D008231:Lymphopenia / Q000209:etiology*; D008875:Middle Aged; D011014:Pneumonia / Q000276:immunology* / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000276:immunology; D011019:Pneumonia, Mycoplasma / Q000276:immunology; D011020:Pneumonia, Pneumocystis / Q000276:immunology; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000166:cytology; D014376:Tuberculosis / Q000276:immunology