The prognostic implications of chemotherapy in the treatment of breast cancer.
Randomized trials with long follow-up confirm the beneficial effect of adjuvant chemotherapy in most groups of patients with operable breast cancer. The use of chemotherapy in large tumours before surgery does not appear to jeopardize survival. High-dose chemotherapy and the use of taxoids may change the natural history of metastatic disease.
O'Brien
M E
ME
Breast Unit, Royal Marsden Hospital, London, UK.
Smith
I E
IE
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate