Case reports: continuous corticosteroids for refractory poorly differentiated lymphocytic lymphoma.
Two patients with stage IV poorly differentiated lymphocytic lymphoma became refractory to intensive combination chemotherapy that contained intermittent corticosteroids. Both patients had evidence of bone marrow replacement and leukemia. Continuous corticosteroids were substituted and produced remissions for more than 1 year for both patients. This alteration in schedule offers an inexpensive and effective palliative treatment for this incurable disease.
Newcom
S R
SR
Division of Hematology/Oncology, Department of Medicine, Grady Memorial Hospital, Atlanta, Georgia, USA.
D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000188:drug therapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D012074:Remission Induction
D018931:Antineoplastic Agents, Hormonal; D011241:Prednisone