title: Radical radiotherapy for T3 laryngeal cancers.
abstract: OBJECTIVE
  Evaluation of the local control rate and voice preservation probability in radically irradiated patients with T3 laryngeal cancer.
  
  
  METHODS
  From 1974 through 1992, 37 previously untreated patients with T3 laryngeal cancer (supraglottic 15, glottic 22) were treated with initial radical radiotherapy and surgery for salvage.
  
  
  RESULTS
  Two-year local control rate with radiotherapy alone, ultimate voice preservation rate, and ultimate local control rate for T3 supraglottic cancer were 33%, 33%, and 60%, respectively. Corresponding figures for T3 glottic cancer were 32%, 23%, and 77%, respectively. Five-year cause-specific survival rate for T3 supraglottic cancer and glottic cancer were 47% and 77%, respectively. In T3 supraglottic cancer, none of the 4 patients with subglottic tumor extension attained local control by radiotherapy alone, and local-regional recurrence-free time were significantly shorter in patients with subglottic tumor extension or tracheostomy before radiotherapy. There were no serious late complications such as chondronecrosis, rupture of carotid artery attributed to radical radiotherapy, while 3 patients had severe laryngeal edema requiring total laryngectomy.
  
  
  CONCLUSIONS
  Current results indicated that initial radical radiotherapy and surgery for salvage might be an option for some patients with T3 laryngeal cancer.
authors.affiliation: Department of Radiation Therapy and Oncology, International Medical Center of Japan, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Uno
authors.forename: J
authors.initials: J
authors.lastname: Itami
authors.forename: K
authors.initials: K
authors.lastname: Kotaka
authors.forename: M
authors.initials: M
authors.lastname: Toriyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods