[Peripheral neuropathies caused by disulfiram].
Disulfirame is a rare cause of peripheral neuropathy in subjects with chronic alcoholism. We report here a case in a 42-year-old man and present the main clinical features and electrophysiological and pathology results. Disulfamine-induced peripheral neuropathy is dose-dependent and never occurs below 250 mg/d (1/2 tables of Espéral*). The pathogenesis is poorly understood.
Dano
P
P
Service de Neurologie, Hôpital d'Instruction des Armées Laveran, Marseille.
Tammam
D
D
Brosset
C
C
Bregigeon
M
M
D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D004221:Disulfiram / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology
D000427:Alcohol Deterrents; D004221:Disulfiram
Les neuropathies périphériques dues au disulfirame.