Transcriptional regulation of the 5-HT2A receptor.
Complex transcriptional control mechanisms are responsible for the cell-type and antidepressant-induced regulation of the 5-HT2A receptor. Repressor domains in the 5' flanking region of the 5-HT2A receptor gene are the primary determinants to generate neuronal cell-specific transcription. Glial cell expression of the 5-HT2A receptor is achieved through a cell-type specific promoter activation. The downregulation of the 5-HT2A receptor by the atypical antidepressant mianserin is mediated by a drug response sequence in the 5' flanking region of the receptor gene.
Toth
M
M
Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D006801:Humans; D011985:Receptors, Serotonin / Q000096:biosynthesis* / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects
D000928:Antidepressive Agents; D011985:Receptors, Serotonin