title: Mammalian artificial chromosomes.
abstract: The development of candidate vectors and of techniques for their manipulation by sequence targeting suggest that a mini-chromosome vector system for the mouse germline may be at hand. Mini-chromosome vectors should allow new sorts of genetic problems to be addressed experimentally and may accelerate the process of gene identification.
authors.affiliation: William Brown, Raoul Heller, Ming-Hong Shen and Aarti Chand, CRC Chromosome Molecular Biology Group, Biochemistry Department, Oxford University, South Parks Road, Oxford OX1 3QU, UK.
authors.initials: W
authors.lastname: Brown
authors.initials: R
authors.lastname: Heller
authors.initials: ML
authors.lastname: Loupart
authors.initials: MH
authors.lastname: Shen
authors.initials: A
authors.lastname: Chand