title: Nifedipine in migraine and tension headache: a randomised double blind crossover study.
abstract: Nifedipine was evaluated in the prophylaxis of 28 patients each of migraine and tension headache using a double blind cross over design with random allocation to drug or placebo group. The duration of the trial was 3 months with a 2 week run-in period and 2 week wash-oat period separating two treatment periods of 4 weeks each. A satisfactory response was obtained in 71.4% of migraineurs (p < 0.001) and 28.6% of patients with tension headache (p = N.S). Minor side effects were observed in 5 patients. Nifedipine is a useful agent for the management of migraine as it reduces frequency and severity of pain but the drug cannot be recommended for tension headache.
authors.affiliation: Department of Neurology, King George's Medical College, Lucknow.
authors.forename: R
authors.initials: R
authors.lastname: Shukla
authors.forename: R K
authors.initials: RK
authors.lastname: Garg
authors.forename: D
authors.initials: D
authors.lastname: Nag
authors.forename: R C
authors.initials: RC
authors.lastname: Ahuja
mesh_terms: D000328:Adult; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000517:prevention & control*; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D018781:Tension-Type Headache / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine