Successful treatment of scleroderma with PUVA therapy.
PUVA therapy was carried out on four patients with scleroderma; three of them had cutaneous manifestations of progressive systemic sclerosis and one other exhibited generalized morphea. PUVA therapy was given with daily doses of 0.25J/cm2 or 0.4J/cm2 for 3-8 weeks, resulting in total doses between 3.5J/cm2 and 9.6J/cm2. All four patients responded well to this treatment; improvements of hand closure, skin sclerosis index, and flexion of fingers or knee joints were obtained. Thus, PUVA appeared to be beneficial for treating scleroderma.
Kanekura
T
T
Department of Dermatology, Kagoshima University Faculty of Medicine, Japan.
Fukumaru
S
S
Matsushita
S
S
Terasaki
K
K
Mizoguchi
S
S
Kanzaki
T
T
D000328:Adult; D000368:Aged; D005260:Female; D005384:Finger Joint / Q000503:physiopathology; D006225:Hand / Q000503:physiopathology; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D016059:Range of Motion, Articular; D012594:Scleroderma, Localized / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000473:pathology