Synthesis and antidepressant evaluation of new hetero[2,1]benzothiazepine derivatives.
As a part of a research program directed to the discovery of novel antidepressant agents, a series of new hetero[2,1]benzothiazepine derivatives was synthesized. Some of these compounds antagonized the ptosis and motor depression induced by tetrabenazine and were also active in the Porsolt forced swimming test.
Díaz
J A
JA
Instituto de Química Médica, CSIC, Madrid, Spain.
Vega
S
S
Expósito
M A
MA
Sánchez Mateo
C C
CC
Darias
V
V
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D001552:Benzazepines