Analysis of quantitative risk factors for a common oligogenic disease.
All three simulated loci influencing the quantitative variables Q1, Q2 and Q3 were successfully mapped by using a strategy of covariate adjustment and segregation analysis, coupled with association analyses and lod-score analyses.
Goddard
K A
KA
Department of Biostatistics, University of Washington, Seattle 98195, USA.
Jarvik
G P
GP
Graham
J
J
McNeney
B
B
Hsu
L
L
Siegmund
K
K
Grosser
S
S
Olson
J
J
Wijsman
E M
EM
D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D016014:Linear Models; D015810:Linkage Disequilibrium; D008126:Lod Score; D010641:Phenotype; D012307:Risk Factors
D005819:Genetic Markers