t-Plasminogen activator and von Willebrand factor in patients with unstable angina.
We investigated whether the clinical evolution of symptoms in patients admitted with unstable angina is associated with changes in t-plasminogen activator antigen (t-PA) and von Willebrand (vW) factor levels. Concentrations of vW factor antigen and t-PA antigen were measured by an enzyme-linked immunoassay method in 10 patients who became clinically stable within 24 h of admission and remained so for 5 days. A significant rise in morning t-PA plasma level occurred 24 h after the admission (15.15 +/- 2.1 ng/ml, P < 0.05), whereas the vW factor remained unchanged. No significant changes were found in the night concentration in t-PA and vW factor during the 5 day period. Thus t-PA level is significantly raised 24 h after admission in patients with unstable angina who stabilize in response to medical treatment.
Tousoulis
D
D
Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece.
Bosinakou
E
E
Tentolouris
C
C
Apostolopoulos
T
T
Copshari
C
C
Kyriakides
M
M
Toutouzas
P
P
D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D010959:Tissue Plasminogen Activator / Q000032:analysis* / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis*
D014841:von Willebrand Factor; D010959:Tissue Plasminogen Activator