Immunoglobulin and complement complexes in blood following infection with human immunodeficiency virus type 1.
Freely soluble and complexed plasma immunoglobulin A (IgA), IgG, IgM, C1q, C3, and factor B in 36 human immunodeficiency virus type I (HIV-1)-seronegative controls, 69 asymptomatic HIV+ subjects, and 117 individuals with symptomatic HIV-associated disease were characterized. Levels of free and complexed IgG and IgA, and to a lesser extent free C1q and complexed IgM, increased with HIV-1 infection. In stark contrast, both HIV+ groups showed three- to sixfold declines in complexed C3, C1q, and factor B levels. The asymptomatic HIV+ population showed declines in levels of C3-bound IgA, IgG2, and IgG4 complexes. The asymptomatic group showed reductions in C3-complexed IgM, IgA, IgG2, and IgG4 levels. HIV infection is associated with complement-deficient immune complexes.
Peng
X X
XX
Department of Biological Science and Technology, Nanchang University, People's Republic of China.
Wainberg
M A
MA
Tao
Y
Y
Brenner
B G
BG
D000936:Antigen-Antibody Complex / Q000097:blood*; D016022:Case-Control Studies; D015922:Complement C1q / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D011415:Complement Factor B / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D015658:HIV Infections / Q000145:classification / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D012995:Solubility
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D015922:Complement C1q; D003165:Complement System Proteins; D011415:Complement Factor B