title: Survey of haemolytic-uraemic syndrome in Queensland 1979-1995.
abstract: OBJECTIVE
  To review the clinical course of haemolytic-uraemic syndrome (HUS) in children admitted to Brisbane children's hospitals between April 1979 and October 1995.
  
  
  METHODS
  Retrospective case survey.
  
  
  METHODS
  Royal Children's Hospital and Mater Misericordiae Children's Hospital (the two major children's hospitals in Brisbane).
  
  
  METHODS
  All children hospitalised for HUS.
  
  
  METHODS
  Clinical and laboratory features on presentation (including typical [diarrhoea-positive, D+] or atypical [diarrhoea-negative, D-] presentation), clinical course, treatment and features on subsequent outpatient follow-up (1, 3, 6 and 12 months later), renal outcome on long term follow-up (3-16 years later).
  
  
  RESULTS
  55 children (aged 2 months to 13 years) were hospitalised for HUS, but no epidemic was detected. Seven children (13%) had D- presentations, including three (5%) with T-activation caused by pneumococcal pneumonia. Thrombocytopenia was more severe and prolonged in D- patients (P < 0.01). Major complications occurred only in the D+ group (one patient died, and two had recurrences). Chronic renal failure was significantly more likely in patients with prolonged oliguria or hypertension in the acute illness and proteinuria or hypertension on follow-up.
  
  
  CONCLUSIONS
  The clinical course and outcome in childhood HUS vary greatly and D- HUS is not invariably associated with a poorer prognosis than D+ HUS. Pneumococcal-associated T-activation is an important cause of D- HUS and should be actively sought to allow for appropriate therapy.
authors.affiliation: Royal Children's Hospital, Brisbane, QLD.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizusawa
authors.forename: L A
authors.initials: LA
authors.lastname: Pitcher
authors.forename: J R
authors.initials: JR
authors.lastname: Burke
authors.forename: M C
authors.initials: MC
authors.lastname: Falk
authors.forename: W
authors.initials: W
authors.lastname: Mizushima
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D011793:Queensland; D012008:Recurrence; D012189:Retrospective Studies