title: Metocurine pharmacokinetics and pharmacodynamics in goats.
abstract: Non-depolarizing muscle relaxants can facilitate surgery and anaesthesia in numerous species. and volatile inhalational anaesthetics such as isoflurane potentiate their action. We studied the effect of isoflurane on the pharmacodynamics and pharmacokinetics of metocurine in six goats. Each was studied twice: once during barbiturate-opiate anaesthesia and once during isoflurane anaesthesia. The evoked response to sciatic nerve stimulation was measured using a force transducer attached to the hoof. Metocurine was infused until approximately 80-90% blockade. Plasma metocurine concentration was determined by high-performance liquid chromatography. Isoflurane increased the potency of metocurine significantly; IC50 (the concentration in the effect compartment at 50% paralysis) was 70 +/- 15 ng/mL during isoflurane anaesthesia and 129 +/- 42 ng/mL during barbiturate-opiate anaesthesia (P < 0.03). Volume of distribution (63 +/- 18 mL/kg), clearance (1.6 +/- 0.4 mL/min.kg) and elimination half-life (99 +/- 9 min) during barbiturate-opiate anaesthesia were not significantly different during isoflurane anaesthesia: 64 +/- 25 mL/kg, 1.5 +/- 0.7 mL/kg.min, 116 +/- 16 min respectively. We conclude that, relative to barbiturate-opiate anaesthesia, isoflurane potentiates metocurine in goats.
authors.affiliation: Department of Anesthesiology, University of California, Davis 95616-8634, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Antognini
authors.forename: R
authors.initials: R
authors.lastname: Wood
authors.forename: G A
authors.initials: GA
authors.lastname: Gronert
mesh_terms: D000758:Anesthesia / Q000662:veterinary; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004357:Drug Synergism; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006041:Goats / Q000378:metabolism* / Q000502:physiology; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009294:Narcotics / Q000008:administration & dosage; D009467:Neuromuscular Depolarizing Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D012584:Sciatic Nerve / Q000187:drug effects; D014403:Tubocurarine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D018685:Anesthetics, Inhalation; D001463:Barbiturates; D009294:Narcotics; D009467:Neuromuscular Depolarizing Agents; D007530:Isoflurane; C032943:metocurine; D014403:Tubocurarine