title: Role of physiology in the determination of protein heterogeneity.
abstract: One of the major problems faced in the manufacture of recombinant proteins is the assessment and control of product heterogeneity, which is caused mainly by the biological variation in post-translational processing. The past year has witnessed significant improvements both in analytical methods for detecting variation in this processing and in our ability to control it.
authors.affiliation: Department of Biological Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK. njenkins@dmu.ac.uk
authors.forename: N
authors.initials: N
authors.lastname: Jenkins
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D010450:Endopeptidases / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D011994:Recombinant Proteins; D010450:Endopeptidases