title: Dornase in treatment of chronic bronchitis.
abstract: At this time, dornase is approved only for the treatment of patients with cystic fibrosis. Based on the results of the trials discussed, dornase appears to be well tolerated by patients with chronic bronchitis. However, the therapeutic benefit of dornase in chronic bronchitis remains unclear. Until further studies are published, dornase cannot be recommended as a routine treatment modality for management of patients with chronic bronchitis.
authors.affiliation: Department of Pharmacy Services, University Hospital, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Hudson
mesh_terms: D001991:Bronchitis / Q000188:drug therapy*; D002908:Chronic Disease; D003850:Deoxyribonuclease I / Q000009:adverse effects / Q000627:therapeutic use*; D005100:Expectorants / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D005100:Expectorants; D011994:Recombinant Proteins; C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I