Canalicular cholestasis due to amiodarone toxicity. A definite diagnosis obtained by electron microscopy.
A case of jaundice due to canalicular cholestasis during amiodarone therapy is reported. A definite diagnosis was attained by ultrastructural evidence of a phospholipidosis pattern, a characteristic amiodarone-induced injury. Jaundice occurred within the third month of therapy. Serum bilirubin levels continued to increase in the two weeks following drug withdrawal. A slow decrease was observed in the following three months. Only four cases of jaundice associated with amiodarone therapy have been reported until now.
Macarri
G
G
Clinica di Gastroenterologia e Cattedra di Citopatologia, Università di Ancona, Italy.
Feliciangeli
G
G
Berdini
V
V
Jezequel
A M
AM
Benedetti
A
A
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001648:Bile Canaliculi / Q000473:pathology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D014665:Vasodilator Agents / Q000009:adverse effects*
D000889:Anti-Arrhythmia Agents; D014665:Vasodilator Agents; D000638:Amiodarone