Antiviral activity of lignans and their glycosides from Justicia procumbens.
Ten antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O-glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O-glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml-1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33).
Asano
J
J
Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Japan.
Chiba
K
K
Tada
M
M
Yoshii
T
T
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D052117:Benzodioxoles; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002681:China; D004148:Dioxolanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008168:Lung; D015394:Molecular Structure; D010946:Plants, Medicinal; D011817:Rabbits; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D000998:Antiviral Agents; D052117:Benzodioxoles; D004148:Dioxolanes; D006027:Glycosides; D017705:Lignans; C010130:diphyllin