title: Purkinje cells express neuronal nitric oxide synthase after methylmercury administration.
abstract: To study the effects of chemical injury on the cerebellar nitric oxide synthase (NOS), we administered methylmercury chloride subcutaneously to mice, 10 mg/kg/day for 9 days. In the methylmercury-treated cerebellum. Purkinje cells were positive both for NADPH-diaphorase and for neuronal NOS. Calcium-dependent NOS activity was increased to 160% of the controls. The present study suggests the ability of Purkinje cells to produce NO through the expression of neuronal NOS.
authors.affiliation: Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Himi
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: I
authors.initials: I
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Yuasa
authors.forename: S
authors.initials: S
authors.lastname: Murota
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D008767:Methylmercury Compounds / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D011689:Purkinje Cells / Q000187:drug effects / Q000201:enzymology*; D015431:Weight Loss / Q000187:drug effects
chemical_list: D008767:Methylmercury Compounds; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase