Determination of oenothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum.
Several extracts from Epilobium parviflorum, a plant used in Central Europe for the treatment of prostate disorders, were evaluated in a biochemical assay with 5-alpha-reductase. The aqueous extract displaying inhibition of the enzyme was analyzed, the fraction responsible for this activity was purified, and the active compound identified as a macrocyclic tannin, oenothein B (1).
Lesuisse
D
D
Centre de Recherche ROUSSEL UCLAF, Roumainville, France.
Berjonneau
J
J
Ciot
C
C
Devaux
P
P
Doucet
B
B
Gourvest
J F
JF
Khemis
B
B
Lang
C
C
Legrand
R
R
Lowinski
M
M
Maquin
P
P
Parent
A
A
Schoot
B
B
Teutsch
G
G
D058891:5-alpha Reductase Inhibitors; D001317:Austria; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D047348:Hydrolyzable Tannins; D066298:In Vitro Techniques; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D011467:Prostate / Q000201:enzymology; D013056:Spectrophotometry, Ultraviolet; D013634:Tannins / Q000032:analysis / Q000494:pharmacology*
D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D047348:Hydrolyzable Tannins; D013634:Tannins; C080077:oenothein B