title: Ex vivo culture systems for hematopoietic cells.
abstract: During the past few years, hematopoietic cell culture technologies for transplantation therapies have progressed significantly on several fronts. Advances include the discoveries of the growth factors thrombopoietin and Flt-3 ligand, the development of a variety of bioreactor systems, and results from preliminary clinical trials that demonstrate the efficacy of ex vivo expanded hematopoietic cells for transplantation therapy.
authors.affiliation: Department of Chemical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3120, USA. wmmiller@nwu.edu
authors.forename: P C
authors.initials: PC
authors.lastname: Collins
authors.forename: E T
authors.initials: ET
authors.lastname: Papoutsakis
authors.forename: W M
authors.initials: WM
authors.lastname: Miller
mesh_terms: D001769:Blood; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D016895:Culture Media, Serum-Free; D005285:Fermentation; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology; D006801:Humans
chemical_list: D016895:Culture Media, Serum-Free; D016298:Hematopoietic Cell Growth Factors