A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma.
Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.
Gaugler
B
B
Ludwig Institute for Cancer Research, Brussels Branch, 74 avenue Hippocrate, UCL 7459, B1200 Brussels, Belgium.
Brouwenstijn
N
N
Vantomme
V
V
Szikora
J P
JP
Van der Spek
C W
CW
Patard
J J
JJ
Boon
T
T
Schrier
P
P
Van den Eynde
B J
BJ
D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D002292:Carcinoma, Renal Cell / Q000276:immunology*; D002461:Cell Line, Transformed; D002522:Chlorocebus aethiops; D018076:DNA, Complementary / Q000235:genetics; D005136:Eye Proteins / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D005796:Genes; D015793:HLA-B7 Antigen / Q000276:immunology; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology*; D020928:Mitogen-Activated Protein Kinases; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology; D012160:Retina / Q000276:immunology; D016415:Sequence Alignment; D017385:Sequence Homology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014162:Transfection
D000951:Antigens, Neoplasm; D018076:DNA, Complementary; D005136:Eye Proteins; D015793:HLA-B7 Antigen; C498978:MOK protein, human; D020928:Mitogen-Activated Protein Kinases