The antipsychotic potential of subtype-selective 5-HT receptor ligands based on interactions with mesolimbic dopamine systems.
Many neurochemical, electrophysiological and behavioural studies have shown how 5-HT and dopamine neuronal systems are able to interact and it is highly likely that the therapeutic benefits of clozapine-like atypical antipsychotic drugs are achieved by the modulation of such interactions. There are, however, at least fourteen subtypes of 5-HT receptor and five subtypes of dopamine receptor expressed in rodent and/or human brain and the optimum combination of receptor affinities required for maximum therapeutic benefit remains enigmatic.
Tricklebank
M D
MD
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Essex, UK. mark.tricklebank@gwa.sandoz.com
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008024:Ligands; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects*
D014150:Antipsychotic Agents; D008024:Ligands; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D004298:Dopamine