UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties.
Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifungal activities of UK-2 compounds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.
Ueki
M
M
Faculty of Science, Osaka City University, Japan.
Abe
K
K
Hanafi
M
M
Shibata
K
K
Tanaka
T
T
Taniguchi
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D005285:Fermentation; D005998:Glycine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D010101:Oxygen Consumption / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014529:Uridine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D007783:Lactones; D011725:Pyridines; C101439:UK 2A; C101494:UK 2B; C101495:UK 2C; C101496:UK 2D; C078136:UK 21; D005998:Glycine; D014529:Uridine