Induction of multifollicular growth in patients non responding to clomiphene citrate and gonadotropins or gonadotropins only.
OBJECTIVE
We aimed at inducing multifollicular recruitment in patients with chronic anovulation-resistant to Clomiphene Citrate (CC) and/or exogenous gonadotropins.


METHODS
At the II Department of Obstetrics and Gynecology we treated our patients with exogenous gonadotropins and concomitant endogenous gonadotropin suppression obtained by the use of a GnRH analog (Buserelin).


METHODS
We studied 14 patients with chronic anovulation due to either hypothalamic dysfunction or polycystic ovarian syndrome.


METHODS
We monitored the follicular growth ultrasonographically from the eighth day of the menstrual cycle, and assessed E2 and LH daily dosage from the tenth day.


RESULTS
With this protocol we obtained 2 or 3 mature follicles, and reached an ovulatory rate of 80.7% and a pregnancy rate of 71.4%. Premature luteinization never occurred, and progesterone increase took place only after human chorionic gonadotropins administration.
Tartagni
M
M
2nd Department of Obstetrics and Gynecology, University of Bari, Italy.
Diaferia
A
A
Nicastri
P L
PL
Loizzi
P
P
D000328:Adult; D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002064:Buserelin / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D002996:Clomiphene / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D002996:Clomiphene; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002064:Buserelin