[Chronic persistent coughing successfully treated with ozagrel].
A 25-year-old woman complained of coughing for over 8 weeks. The coughing was not relieved by a bronchodilator (beta 2-adrenoceptor agonist; clenbuterol), and anti-allergic agent (azelastine), or an inhaled corticosteroid. The thromboxane synthetase inhibitor ozagrel completely abolished her cough. In this case, thromboxane A2 may have contributed to the coughing.
Nishi
K
K
Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Mizuguchi
M
M
Tachibana
H
H
Ooka
T
T
Fujimura
M
M
Matsuda
T
T
D000328:Adult; D000996:Antitussive Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D003371:Cough / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008689:Methacrylates / Q000627:therapeutic use*; D013928:Thromboxane A2 / Q000502:physiology; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D000996:Antitussive Agents; D008689:Methacrylates; D013928:Thromboxane A2; D013930:Thromboxane-A Synthase; C034364:ozagrel