title: Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein kinase II (CaM kinase II) inhibitor, KN-62, and proposal of CaM kinase phosphorylation cascades.
authors.affiliation: Department of Pharmacology, Nagoya University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hidaka
authors.forename: H
authors.initials: H
authors.lastname: Yokokura
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002319:Cardiovascular System / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000096:biosynthesis; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009130:Muscle, Smooth / Q000502:physiology; D018994:Myosin Light Chains / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010179:Pancreas / Q000378:metabolism; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D002147:Calmodulin; D004791:Enzyme Inhibitors; D018994:Myosin Light Chains; D047428:Protein Kinase Inhibitors; D013449:Sulfonamides; D004295:Dihydroxyphenylalanine; C063302:KN 62; C017967:W 7; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D014446:Tyrosine 3-Monooxygenase; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases