Direct enzymatic assay of urinary sulfated bile acids to replace serum bilirubin testing for selective screening of neonatal cholestasis.
Direct enzymatic assay of urinary sulfated bile acids is a sensitive, rapid, minimally invasive, and convenient method of detecting cholestasis in young infants. It may replace measurement of serum direct bilirubin for selective screening for biliary atresia and neonatal hepatitis syndrome at 1 month of age.
Matsui
A
A
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Kasano
Y
Y
Yamauchi
Y
Y
Momoya
T
T
Shimada
T
T
Ishikawa
T
T
Abukawa
D
D
Kimura
A
A
Adachi
K
K
Tazuke
Y
Y
D001647:Bile Acids and Salts / Q000652:urine*; D001656:Biliary Atresia / Q000097:blood / Q000175:diagnosis / Q000652:urine; D001663:Bilirubin / Q000097:blood*; D002779:Cholestasis / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000175:diagnosis / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D012680:Sensitivity and Specificity; D013431:Sulfates / Q000652:urine; D013577:Syndrome
D001647:Bile Acids and Salts; D013431:Sulfates; D001663:Bilirubin