title: Screening for coeliac disease in Dutch children with associated diseases.
abstract: Our objective was to assess the frequency of coeliac disease in children with associated disorders in the province of "Zuid-Holland". The Netherlands. We therefore screened 115 children with Down's syndrome, 62 children with juvenile rheumatoid arthritis (JRA) and 46 children with diabetes mellitus for CD using the IgA-class of antigliadin, antiendomysium and antireticulin antibodies in serum, and a functional sugar absorption test. The antiendomysium antibody test was the screening test that performed the best. Every patient who has at least one positive test underwent a jejunal biopsy for the diagnosis of CD. No association could be demonstrated between CD and diabetes mellitus. The frequency of CD in Down's syndrome was 7.0%, which is much higher than that found from screening the general population. CD was found in one child with JRA (1.5%), who also had Down's syndrome. We recommend screening for CD in all persons with Down's syndrome using at least the antiendomysium antibody test.
authors.affiliation: Department of Paediatrics, University Hospital Leiden, The Netherlands.
authors.forename: E K
authors.initials: EK
authors.lastname: George
authors.forename: M L
authors.initials: ML
authors.lastname: Mearin
authors.forename: J
authors.initials: J
authors.lastname: Bouquet
authors.forename: B M
authors.initials: BM
authors.lastname: von Blomberg
authors.forename: S O
authors.initials: SO
authors.lastname: Stapel
authors.forename: R M
authors.initials: RM
authors.lastname: van Elburg
authors.forename: E A
authors.initials: EA
authors.lastname: de Graaf
authors.forename: R
authors.initials: R
authors.lastname: Hertzberger-ten Cate
authors.forename: L W
authors.initials: LW
authors.lastname: van Suijlekom-Smith
authors.forename: H M
authors.initials: HM
authors.lastname: Reeser
authors.forename: W
authors.initials: W
authors.lastname: Oostdijk
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications*; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis; D002648:Child; D048909:Diabetes Complications; D004314:Down Syndrome / Q000150:complications*; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D008403:Mass Screening / Q000379:methods; D009426:Netherlands; D012698:Serologic Tests / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D007070:Immunoglobulin A; D005903:Gliadin