Screening for coeliac disease in Dutch children with associated diseases.
Our objective was to assess the frequency of coeliac disease in children with associated disorders in the province of "Zuid-Holland". The Netherlands. We therefore screened 115 children with Down's syndrome, 62 children with juvenile rheumatoid arthritis (JRA) and 46 children with diabetes mellitus for CD using the IgA-class of antigliadin, antiendomysium and antireticulin antibodies in serum, and a functional sugar absorption test. The antiendomysium antibody test was the screening test that performed the best. Every patient who has at least one positive test underwent a jejunal biopsy for the diagnosis of CD. No association could be demonstrated between CD and diabetes mellitus. The frequency of CD in Down's syndrome was 7.0%, which is much higher than that found from screening the general population. CD was found in one child with JRA (1.5%), who also had Down's syndrome. We recommend screening for CD in all persons with Down's syndrome using at least the antiendomysium antibody test.
George
E K
EK
Department of Paediatrics, University Hospital Leiden, The Netherlands.
Mearin
M L
ML
Bouquet
J
J
von Blomberg
B M
BM
Stapel
S O
SO
van Elburg
R M
RM
de Graaf
E A
EA
Hertzberger-ten Cate
R
R
van Suijlekom-Smith
L W
LW
Reeser
H M
HM
Oostdijk
W
W
D001171:Arthritis, Juvenile / Q000150:complications*; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis; D002648:Child; D048909:Diabetes Complications; D004314:Down Syndrome / Q000150:complications*; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D008403:Mass Screening / Q000379:methods; D009426:Netherlands; D012698:Serologic Tests / Q000379:methods / Q000706:statistics & numerical data
D007070:Immunoglobulin A; D005903:Gliadin