Assays of omeprazole metabolism as a substrate probe for human CYP isoforms.
Birkett
D J
DJ
Department of Clinical Pharmacology, Flinders University of South Australia, Bedford Park.
Andersson
T
T
Miners
J O
JO
D001189:Aryl Hydrocarbon Hydroxylases; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000032:analysis / Q000378:metabolism; D015335:Molecular Probes; D009853:Omeprazole / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D054328:Proton Pump Inhibitors
D004791:Enzyme Inhibitors; D015335:Molecular Probes; D054328:Proton Pump Inhibitors; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; C104464:CYP3A protein, human; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; D009853:Omeprazole