Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons.
Enteric nerves express multiple receptors for 5-hydroxytryptamine (5-HT). Three excitatory and 1 inhibitory receptor for 5-HT can be identified using electrophysiological methods. The excitatory receptors are the 5-HT1P, 5-HT3 and 5-HT4 subtypes. The 5-HT1P mediates slow depolarizations (> 10 s duration) of many enteric nerves and 5-HT1P receptors mediate some slow excitatory synaptic potentials. The 5-HT3 receptor is a ligand-gated cation channel that mediates fast depolarizations (< 2 s). The 5-HT4 receptor mediates presynaptic facilitation of fast excitatory neurotransmission. The inhibitory receptor is the 5-HT1A receptor. 5-HT1A receptors mediate hyperpolarizations in AH neurons and presynaptic inhibition of fast and slow excitatory neurotransmission.
Galligan
J J
JJ
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA.
D000818:Animals; D004594:Electrophysiology; D017615:Enteric Nervous System / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D011985:Receptors, Serotonin