Pancytopenia due to vitamin B12 deficiency associated with Graves' disease.
Pancytopenia has a broad differential diagnosis, which can be narrowed depending on the cellularity of the bone marrow. The authors describe a complex patient with a history of Graves' disease who presented with pancytopenia, initially suspected of being due to aplastic anemia. He was later diagnosed with Vitamin B12 deficiency as a result of pernicious anemia. The potentially striking hematologic effects of cobalamin deficiency and the autoimmune basis for concurrent Graves' disease and pernicious anemia are reviewed.
Burns
R W
RW
University of Missouri-Columbia, School of Medicine 65203, USA.
Burns
T W
TW
D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006111:Graves Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology* / Q000473:pathology; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000473:pathology