title: The effects of L-deprenyl on spatial short term memory in young and aged dogs.
abstract: 1. Young and aged dogs were tested on a spatial memory task using a delayed non matching to sample technique. Dogs were tested with 20, 70 and 110 second delay intervals. Animals were pretrained to a stable level of performance prior to treatment. 2. During treatment periods, dogs were orally administered a placebo or I-deprenyl in doses of 0.5 and 1.0 mg/kg in a repeated measures design. 3. Young dogs did not show any significant effects of I-deprenyl, however the sample size was limited. 4. L-deprenyl administration improved spatial memory in aged dogs. 5. The optimal dose or length of treatment time of I-deprenyl varied among individual dogs.
authors.affiliation: University of Toronto, Division of Life Sciences, Scarborough, Ontario, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Head
authors.forename: J
authors.initials: J
authors.lastname: Hartley
authors.forename: A M
authors.initials: AM
authors.lastname: Kameka
authors.forename: R
authors.initials: R
authors.lastname: Mehta
authors.forename: G O
authors.initials: GO
authors.lastname: Ivy
authors.forename: W W
authors.initials: WW
authors.lastname: Ruehl
authors.forename: N W
authors.initials: NW
authors.lastname: Milgram
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D012642:Selegiline / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D012642:Selegiline