Intrasplenic masses of "preserved" functioning splenic tissue in sickle cell disease: correlation of imaging findings (CT, ultrasound, MRI, and nuclear scintigraphy).
OBJECTIVE
We studied six patients with sickle cell disease (SSD), five homozygous for sickle cell anemia and one with sickle beta-thalassemia, in whom rounded intrasplenic masses proved to be preserved functioning splenic tissue.


METHODS
Available images including computed tomography, ultrasonography, bone scans (Tc-99m MDP), liver spleen scans (Tc-99m sulfur colloid), and MRI were evaluated.


RESULTS
The masses were low density on CT (in an otherwise calcified spleen), hypoechoic relative to the echogenic spleen on US, and had the imaging characteristics of normal spleen on MRI. They failed to accumulate Tc-99m MDP but did demonstrate uptake of Tc-99m sulfur colloid.


CONCLUSIONS
In a patient with SSD and intrasplenic masses, proper correlation of multiple imaging modalities will establish the diagnosis of functioning splenic tissue and avoid mistaken diagnosis of splenic abscess or infarction.
Levin
T L
TL
Department of Radiology, Columbia-Presbyterian Medical Center, Babies & Children's Hospital of New York, 3959 Broadway, BHN 3-318, New York, NY 10032, USA.
Berdon
W E
WE
Haller
J O
JO
Ruzal-Shapiro
C
C
Hurlet-Jenson
A
A
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology*; D013669:Technetium Tc 99m Medronate; D013671:Technetium Tc 99m Sulfur Colloid; D014055:Tomography, Emission-Computed / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography / Q000379:methods
D013671:Technetium Tc 99m Sulfur Colloid; D013669:Technetium Tc 99m Medronate