title: Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
abstract: An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.
authors.affiliation: Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
authors.forename: H D
authors.initials: HD
authors.lastname: Sun
authors.forename: S X
authors.initials: SX
authors.lastname: Qiu
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lin
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: Z W
authors.initials: ZW
authors.lastname: Lin
authors.forename: T
authors.initials: T
authors.lastname: Pengsuparp
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: H H
authors.initials: HH
authors.lastname: Fong
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
mesh_terms: D002681:China; D054303:HIV Reverse Transcriptase; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D018894:Reverse Transcriptase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; C100860:nigranoic acid; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase