[The role of nitrates in therapy of heart failure].
For nitrates their efficacy in acute and chronic heart failure has to be differentiated. In acute heart failure the hemodynamic and symptomatic improvements after administration of short term nitrate therapy render this form of therapy a standard medication. In contrast, the therapy with nitrates in chronic heart failure has not significantly improved prognosis especially when compared with ACE-inhibitors. On the contrary, nitrates in chronic heart failure tend to increase the sympathetic tone which is negatively correlated to survival. Thus, nitrates are only adjunctive therapy in patients with chronic heart failure.
Strasser
R H
RH
Innere Medizin III/Kardiologie, Universität Heidelberg.
D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009566:Nitrates / Q000009:adverse effects / Q000627:therapeutic use*; D015996:Survival Rate; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
D009566:Nitrates; D014665:Vasodilator Agents
Rolle der Nitrate in der Therapie der Herzinsuffizienz.