Progesterone profiles in luteal-phase defects associated with recurrent spontaneous abortions.
OBJECTIVE
Histologically documented luteal-phase defects (LPD) have been detected in 20-40% of women with recurrent spontaneous abortions. In 28 patients with recurrent spontaneous abortions, luteal-phase serum progesterone (P) levels (days 19, 21, 23, 25) and endometrial biopsies were evaluated.


METHODS
On the basis of endometrial biopsy findings, the patients were separated into two groups: Group 1, recurrent spontaneous abortions with LPDs (n = 18); and Group 2, recurrent spontaneous abortions with normal biopsies (n = 7). The data are shown in the table below.


CONCLUSIONS
This study demonstrated that the P values found in Group 1 were significantly lower than those in Group 2, almost throughout the luteal phase. The results also indicate a close relationship between the P profile in the luteal phase and endometrial biopsy.
Babalioğlu
R
R
Department of Gynaecology and Obstetrics, Vakif Gureba Hospital, Istanbul, Turkey.
Varol
F G
FG
Ilhan
R
R
Yalçin
O
O
Cizmecioğlu
F
F
D000026:Abortion, Habitual / Q000097:blood*; D000328:Adult; D001706:Biopsy; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000097:blood*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*
D011374:Progesterone