A new cytotoxic compound from a water extract of corn.
A new cytotoxic compound 2 was isolated from a water extract of corn germ. Structural elucidation by spectroscopic data and chemical evidence fully substantiated 2 to be 11 (E)-10-oxo-11-octadecen-13-olide. Compound 2 exhibited considerably strong cytotoxic activity against various cell lines with IC50 of 0.9-2.8 micrograms/ml.
Hayashi
Y
Y
Research Laboratories II, Tamanoi Vinegar Co. Ltd., Osaka, Japan.
Ishihara
N
N
Takahashi
M
M
Fujii
E
E
Uenakai
K
K
Masada
S
S
Ichimoto
I
I
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D003313:Zea mays / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts