title: The type-1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes.
abstract: Thyroglobulin (Tg) proteolytic steps are central phenomena in Tg processing and thyroid hormone release in thyrocytes. Based on recent literature data, we propose that the type-1 repetitive units present in the Tg sequence could act as binders and reversible inhibitors of the proteases implicated in Tg processing. The pH-dependent interactions of proteases with the repeats could permit (i) protection from degradation of low iodinated Tg to be recycled; (ii) restriction of early proteolytic attacks to N- and C-terminal hormone formation sites; (iii) increase of the half-time of acidic proteases necessary for the final, extensive degradation steps of Tg.
authors.affiliation: CNRS UMR 9921-Faculté de Pharmacie, Montpellier, France. fmolina@pharma.univ-montpl.fr
authors.forename: F
authors.initials: F
authors.lastname: Molina
authors.forename: B
authors.initials: B
authors.lastname: Pau
authors.forename: C
authors.initials: C
authors.lastname: Granier
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D013954:Thyroglobulin / Q000378:metabolism*; D013961:Thyroid Gland / Q000166:cytology / Q000378:metabolism*; D013970:Thyronines / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism*
chemical_list: D013970:Thyronines; D013954:Thyroglobulin; D013974:Thyroxine