A family of homologous substrate-binding proteins with a broad range of substrate specificity and dissimilar biological functions.
The uptake of peptides is accomplished mainly by a family of homologous oligopeptide or dipeptide transporters in bacteria. Computer-aided sequence analyses expand members of the oligopeptide-binding protein family to nickel and heme permeases and other proteins, including an enzyme hyaluronate synthase. They are involved in human pathogenicity, bacterial virulence, substrate-sensing, bacterial conjugation and bacterial metabolic reactions distinct from nutrient uptake. These homologous proteins are found in both purple bacteria and Gram-positive bacteria, indicating the presence of a common ancestor before the appearance of the two eubacterial phyla. Nevertheless, the pheromone-binding proteins, involved in bacterial conjugation, and the hyaluronate synthase are present only in the low G-C Gram-positive eubacteria subdivision, which suggests that these proteins diverged from the common ancestor after the appearance of this subdivision.
Wu
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LF
Institut National des Sciences Appliquées, Villeurbanne, France.
Mandrand-Berthelot
M A
MA
D000595:Amino Acid Sequence; D001692:Biological Transport; D002352:Carrier Proteins; D016208:Databases, Factual; D014453:Glucuronosyltransferase; D016695:Glycosyltransferases; D000076002:Hyaluronan Synthases; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D009532:Nickel / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity; D014166:Transferases; D029867:Xenopus Proteins
D002352:Carrier Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009842:Oligopeptides; D029867:Xenopus Proteins; D009532:Nickel; D014166:Transferases; D016695:Glycosyltransferases; D014453:Glucuronosyltransferase; C056944:HAS1 protein, Xenopus; D000076002:Hyaluronan Synthases