Systematic search of susceptibility loci with methods using gametic disequilibrium.
Susceptibility genes are identified for a simulated complex trait by a systematic genome search for linkage between disease and a genetic marker in the presence of gametic disequilibrium. The transmission/disequilibrium tests TDTa or TDTg for multiallelic markers compare transmitted and nontransmitted alleles or the genotypes formed by the two transmitted alleles and the genotypes formed by the two nontransmitted alleles, respectively. With these two tests we were able to identify the two markers D1G31 and D5G23. Under the simulating model these are in fact two susceptibility genes involved in the disease.
Bickeböller
H
H
INSERM U155, Paris, France.
Margaritte-Jeannin
P
P
Babron
M C
MC
Clerget-Darpoux
F
F
D000483:Alleles; D002874:Chromosome Mapping; D003198:Computer Simulation; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium
D005819:Genetic Markers