[Neonatal cholestatic lithiasis associated with E. coli infection].
BACKGROUND
Cholestasis associated with gallbladder lithiasis is quite uncommon in the neonate. We report such a case possibly due to a bacterial infection.


METHODS
A 25 day-old neonate was admitted because he suffered from cholestatic jaundice associated with biological findings of inflammation. Hepatic cellular function and transaminases were normal. Ultrasonography showed hepatomegaly and a 10 mm diameter gallstone with sludge into the gallbladder. The patient was given cefotaxime plus netilmicine. Soluble antigenes for E coli were positive in the urine. Jaundice and inflammatory findings returned to normal within 10 days and ultrasonography was normal at the age of 20 months.


CONCLUSIONS
Neonatal E coli infection could be responsible for gallstone formation since E coli endotoxin may induce biliary stasis and favours lithogenous action of bacterial glycoproteins.
Alissa
K
K
Service de pédiatrie, centre hospitalier, Fontainebleau, France.
Saunier
P
P
Russo
M
M
Vedrenne
J
J
D002769:Cholelithiasis / Q000150:complications* / Q000000981:diagnostic imaging; D002779:Cholestasis / Q000150:complications*; D004927:Escherichia coli Infections / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014463:Ultrasonography
Lithiase cholestatique néonatale associée à une infection à colibacilles.