title: [Early clinical diagnosis of acanthamoeba keratitis. A study of 70 eyes].
abstract: BACKGROUND
  Acanthamoeba keratitis is an uncommon condition which is usually associated with contact lens wear. The use of home made saline and poor hygiene are important risk factors. Early diagnosis is crucial since these cases respond well to medical therapy. The purpose of this paper is to describe and demonstrate early clinical signs.
  
  
  METHODS
  Between September 1992 and October 1994, 70 cases of acanthamoeba keratitis, one of them bilateral, were prospectively monitored at Moorfields Eye Hospital in London. A database of all patients was set up and the clinical findings, diagnostic methods, therapeutic interventions and the outcome were recorded.
  
  
  RESULTS
  66 patients (96%) were contact lens wearers, 64 of them (97%) wore soft lenses. The mean interval between first symptoms and correct diagnosis was 42%. The most frequent initial diagnoses were "unclear keratoconjunctivitis" and "herpetic keratitis". Early corneal findings included punctate keratopathy (n = 14; 20%), pseudodendrites (n = 4; 6%), epithelial infiltrates (n = 17; 24%), diffuse or focal sub-epithelial infiltrates (n = 36; 51%) and radial keratoneuritis (n = 5; 7%). Ring infiltrates (n = 13; 18%) and corneal ulceration (n = 13) were late signs.
  
  
  CONCLUSIONS
  When the above corneal findings are observed, particularly in contact lens wearers, the diagnosis of acanthamoeba keratitis should be considered. The diagnosis of "herpetic keratitis" in association with contact lens wear should be encountered with scepticism.
authors.affiliation: Augenklinik, Universitätsspital Zürich.
authors.forename: W
authors.initials: W
authors.lastname: Bernauer
authors.forename: G I
authors.initials: GI
authors.lastname: Duguid
authors.forename: J K
authors.initials: JK
authors.lastname: Dart
mesh_terms: D015823:Acanthamoeba Keratitis / Q000175:diagnosis* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003261:Contact Lenses; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
vernacular_title: Zur klinischen Frühdiagnose der Acanthamoeben-Keratitis. Eine Studie über 70 Augen.