[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].
The data of 466 subjects suffering from neurologic disorders which are suggested to be caused by neurotoxic agents in their environment retrospectively was evaluated and documented. Among these cases there were 151 subjects with symptoms of Multiple Chemical Sensitivity Disorder (MCSD). The relationship between the neurological health impairments and neurotoxic agents in the environment of these patients was characterised using five different categories (probable = A, possible = B, uncertain = C, unclarified = D, not probable = E). From the 466 patients 320 subjects (69%) could be assigned to the categories A and B, respectively. Within theses 320 cases with chronic neurotoxic health impairments 136 subjects (79 females and 57 males) showed signs of MCSD. Age and gender of cases as well as duration and character of exposure to neurotoxic substances retrospectively were assessed from the explicit files of the patients, which had been made anonymous for this purpose. Frequency of characteristic symptoms of neurotoxicity were analysed. Results are given for patients with neurotoxic health impairments with MCSD (n = 136) and without MCSD (n = 184). Neurotoxic substances which were used as indoor wood preservatives (mainly Pentachlorophenol and/or Lindane) were found to be the causative agents in 63% of the cases with neurotoxic health impairments and MCSD. Other important neurotoxic substances to which the patients were mainly exposed were organic solvents (25%), formaldehyde (15%), dental materials (15%), pyrethroides (13%), and other biocides (19%) (multiple exposures were possible). The time of exposure was calculated as being > or = 10 years for 55% of the patients with MCSD and for 50% of the group with neurotoxic health impairments but without MCSD. Out of the 184 cases with neurotoxic health impairments but without MCSD there were 22%, and out of the 136 cases with MCSD there were 39% who showed all symptoms of chronic fatigue syndrome. 53% of the cases with MCSD had an allergic disposition compared to only 20% of the cases without MCSD. This work is not a controlled epidemiological study but a retrospective documentation and evaluation of data related to environmental medicine. With the present documentation in this purely descriptive manner the proof of a causal relationship was not possible or intended. But because corresponding epidemiological studies are lacking, this documentation can give important information on characteristic features of Multiple Chemical Sensitivity Disorder and chronic neurotoxic health impairments. Such information is essential for planning and carrying out epidemiological studies urgently needed in this field.
Lohmann
K
K
Schleswig, Christian-Albrechts-Universität, Kiel.
Pröhl
A
A
Schwarz
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D016902:Air Pollution, Indoor / Q000009:adverse effects; D002648:Child; D003937:Diagnosis, Differential; D004781:Environmental Exposure / Q000009:adverse effects*; D015673:Fatigue Syndrome, Chronic / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D001556:Hexachlorocyclohexane / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000175:diagnosis*; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D009498:Neurotoxins / Q000009:adverse effects*; D010416:Pentachlorophenol / Q000009:adverse effects; D012997:Solvents / Q000009:adverse effects
D000393:Air Pollutants; D009498:Neurotoxins; D012997:Solvents; D001556:Hexachlorocyclohexane; D010416:Pentachlorophenol
Vielfache Chemikalienunverträglichkeit (Multiple Chemical Sensitivity Disorder) bei Patienten mit neurotoxischen Gesundheitsstörungen.