Comparison of serum histamine-releasing activity and clinical manifestations in chronic idiopathic urticaria.
We found increased serum histamine-releasing activity (HRA) in 27% of patients with chronic idiopathic urticaria. Patterns of clinical manifestations were similar in those with and without serum HRA, including responses to a standard treatment regimen. In HRA+ patients the degree of serum HRA generally correlated with clinical disease activity.
Tanus
T
T
Department of Medicine, University of Pennsylvania, Philadelphia, USA.
Atkins
P C
PC
Zweiman
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D001491:Basophils / Q000276:immunology; D014408:Biomarkers, Tumor; D002908:Chronic Disease; D005260:Female; D006636:Histamine Release; D006801:Humans; D066298:In Vitro Techniques; D008222:Lymphokines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000090324:Tumor Protein, Translationally-Controlled 1; D014581:Urticaria / Q000209:etiology / Q000276:immunology*
D014408:Biomarkers, Tumor; D008222:Lymphokines; D000090324:Tumor Protein, Translationally-Controlled 1