title: Cross-generalization between a cocaine cue and two antihistamines.
abstract: Rats were trained to discriminate between 10 mg/kg cocaine and saline injections under a fixed ratio 10 schedule of food-motivated lever press responding. Once stimulus control was achieved, reinforced test sessions were conducted to assess the degree of generalization of a wide range of cocaine doses and the cross-generalization between the cocaine training stimulus and two over-the-counter antihistaminic drugs, diphenhydramine and doxylamine, when administered with saline or in drug combinations. Cocaine produced a dose-dependent generalization to the 10 mg/kg training stimulus. Cocaine also produced mild rate-increasing effects at low test doses and response rate suppression at higher doses. Both diphenhydramine and doxylamine produced a partial generalization to the 10 mg/kg cocaine training stimulus. Drug mixtures produced complete cross-generalization with the training cue.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 3190-3000, USA.
authors.forename: D V
authors.initials: DV
authors.lastname: Gauvin
authors.forename: K L
authors.initials: KL
authors.lastname: Carl
authors.forename: R J
authors.initials: RJ
authors.lastname: Briscoe
authors.forename: M
authors.initials: M
authors.lastname: Vallett
authors.forename: F A
authors.initials: FA
authors.lastname: Holloway
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003463:Cues; D004155:Diphenhydramine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004319:Doxylamine / Q000494:pharmacology; D005793:Generalization, Psychological / Q000187:drug effects*; D006633:Histamine Antagonists / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule
chemical_list: D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D009294:Narcotics; D004155:Diphenhydramine; D004319:Doxylamine; D003042:Cocaine