title: Relapsing Wegener's granulomatosis: successful treatment with cyclosporin-A.
abstract: We describe the case of a 32-year-old splenectomised man with severe Wegener's granulomatosis which was refractory to conventional treatment with oral cyclophosphamide and prednisolone. Remission was temporarily induced only with plasma exchange or i.v. immunoglobulin. Because of frequent relapses of the disease and cyclophosphamide side effects, he was started on treatment with cyclosporin-A and a long lasting remission was achieved.
authors.affiliation: Department of Rheumatology, District General Hospital of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Georganas
authors.forename: D
authors.initials: D
authors.lastname: Ioakimidis
authors.forename: C
authors.initials: C
authors.lastname: Iatrou
authors.forename: B
authors.initials: B
authors.lastname: Vidalaki
authors.forename: K
authors.initials: K
authors.lastname: Iliadou
authors.forename: P
authors.initials: P
authors.lastname: Athanassiou
authors.forename: T
authors.initials: T
authors.lastname: Kontomerkos
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010951:Plasma Exchange; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D013156:Splenectomy; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; D011239:Prednisolone