Involvement of annexin V in the entry of influenza viruses and role of phospholipids in infection.
Influenza viruses bind to annexin V, a widely spread non-glycosylated phospholipid-binding protein. Externally added phospholipids as well as antiserum against this protein specifically inhibit infection of these viruses in cell cultures. We conclude that annexin V plays an important role in the entry of these viruses.
Huang
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RT
Institut für Molekularbiologic und Biochemie, Freie Universität, Berlin, Germany.
Lichtenberg
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B
Rick
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O
D000818:Animals; D017304:Annexin A5 / Q000378:metabolism*; D000914:Antibodies, Viral / Q000276:immunology; D002213:Capsid / Q000378:metabolism; D002460:Cell Line; D004285:Dogs; D006801:Humans; D009980:Influenza A virus / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013997:Time Factors; D014758:Viral Core Proteins / Q000378:metabolism; D010948:Viral Plaque Assay
D017304:Annexin A5; D000914:Antibodies, Viral; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins; D014758:Viral Core Proteins