The subretinal fibrosis and uveitis syndrome.
The subretinal fibrosis and uveitis syndrome is a rare posterior uveitis characterized in the early stages by a multifocal choroiditis, followed by progressive subretinal fibrosis. It usually is seen in otherwise healthy, young myopic women with no systemic disease. Symptoms include acute, unilateral visual loss, scotomas, metamorphopsia, and photopsias. Ophthalmic examination reveals a mild anterior or posterior uveitis, and transient, multiple, small, whitish-yellow RPE or choroidal lesions in the posterior pole and midperiphery. These lesions fade or enlarge and coalesce to create areas of white subretinal fibrosis, a progression that occurs over weeks to months. The visual prognosis generally is poor, and recurrences are common. Treatment is controversial, with some authors finding an early beneficial effect of steroids and chemotheraphy in severe cases. The etiology is not known, but is believed to be a localized autoimmune reaction to the RPE.
Kaiser
P K
PK
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA.
Gragoudas
E S
ES
D001766:Blindness / Q000150:complications; D005260:Female; D005355:Fibrosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D011379:Prognosis; D012008:Recurrence; D012160:Retina / Q000473:pathology*; D013577:Syndrome; D015866:Uveitis, Posterior / Q000150:complications* / Q000175:diagnosis / Q000628:therapy