Synthesis and cytostatic activity of some sulfamido-anthraquinones.
N-1- or 2-anthraquinonyl derivatives of p-methyl-, p-methoxy- and p-aminobenzenesulfonamides were synthesized and evaluated in vitro as antitumour agents. Only N-(1-anthraquinonyl)-p-methylbenzenesulfonamide (1) and -p-methoxy benzene sulfonamide derivatives 3 and 4 showed slight antitumour activity.
Teijeira
M
M
Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Santana
L
L
Uriarte
E
E
Jorge
M L
ML
Seoane
R
R
D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000880:Anthraquinones; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D013449:Sulfonamides