Frequency of micronuclei in mouse peripheral blood erythrocytes following WR-2721 application and X-irradiation.
The frequency of micronucleated polychromatic erythrocytes (MNPCEs) in the mouse peripheral blood was assessed after WR-2721 (S-2-/3-aminopropylamino/ethyl phosphorothioic acid) application and X-irradiation. A genotoxic effect was demonstrated for X-rays and WR-2721, as well as a protective effect of the thiol drug against X-ray-induced genotoxicity in the erythropoietic system. After X-irradiation of the mice, the number of MNPCEs was distinctly increased. WR-2721 administration prior to X-irradiation resulted in a reduction of the X-ray-induced rise in the frequency of micronuclei. WR-2721 given alone, without subsequent X-irradiation, increased the number of MNPCEs. The genotoxic and radioprotective effect of WR-2721 depended on the dose applied and the time interval between the thiol agent treatment and exposure of the mice to X-rays.
Mazur
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Department of Animal Physiology, Jagiellonian University, Kraków, Poland.
D004999:Amifostine / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000528:radiation effects*; D004920:Erythropoiesis / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000633:toxicity*; D014965:X-Rays / Q000009:adverse effects
D011837:Radiation-Protective Agents; D004999:Amifostine