Validation of a method to study the dissolution behaviour of norfloxacin tablets.
This experimental study examines the development and validation of a new method to evaluate the dissolution rate of norfloxacin tablets. The volume of dissolution medium used here is 100 ml. instead of the 750-900 ml used in the official methods. This smaller volume is closer to that in the human gastric tract. Our main aim is to validate a device which, requiring small volumes of medium, allows the addition of therapeutic amounts of antacids or other substances for in vitro interaction dissolution studies.
Córdoba Borrego
M
M
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
Córdoba Díaz
M
M
Reillo Martín
A
A
Cienfuegos Rodriguez
J M
JM
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D009643:Norfloxacin / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
D000890:Anti-Infective Agents; D009643:Norfloxacin