title: Delayed hypersensitivity at the injection sites of a low-molecular-weight heparin.
abstract: We report a case of delayed hypersensitivity to a low-molecular-weight heparin. The patient presented with eczema at the site of subcutaneous injections and allergy tests confirmed the clinical diagnosis. There were positive tests with 3 low-molecular-weight heparins and unfractionated subcutaneous calcium heparin but negative with intravenous sodium heparin. Although delayed hypersensitivity to low-molecular-weight heparins is rare, the possibility of cross-allergy to unfractionated heparin could be a therapeutic problem for some patients.
authors.affiliation: Department of Dermatology of Caen, France.
authors.forename: A
authors.initials: A
authors.lastname: Moreau
authors.forename: A
authors.initials: A
authors.lastname: Dompmartin
authors.forename: P
authors.initials: P
authors.lastname: Esnault
authors.forename: M
authors.initials: M
authors.lastname: Michel
authors.forename: D
authors.initials: D
authors.lastname: Leroy
mesh_terms: D004485:Eczema / Q000139:chemically induced; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008875:Middle Aged; D010328:Patch Tests
chemical_list: D006495:Heparin, Low-Molecular-Weight