title: [Measurement of glycated hemoglobin with the Abbott IMx automatic analyzer].
abstract: The Abbott IMx assay is an affinity method, based on boronate binding to glycated hemoglobin. A novel separation system, ion capture technology, is used for separation of GHb from non-GHb. Affinity-based GHb methods are reported not to be subject to interference from either aldimine intermediates (pre-Alc fraction) or Hb variants that can comigrate in ion-exchange based chromatographic methods with the HbAlc fraction or with HbAO, having, in both cases, an unreliable % HbA1c result. The purpose of the study was to investigate the analytical performance of the GHb IMx assay, illustrating also a case study involving an abnormal hemoglobin variant.
authors.affiliation: Istituto di Chimica Clinica, Ospedale Generale Regionale, Treviso.
authors.forename: G F
authors.initials: GF
authors.lastname: Caenaro
authors.forename: L
authors.initials: L
authors.lastname: Caberlotto
authors.forename: R
authors.initials: R
authors.lastname: Chirillo
mesh_terms: D001322:Autoanalysis; D005069:Evaluation Studies as Topic; D006442:Glycated Hemoglobin / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans
chemical_list: D006442:Glycated Hemoglobin; D006455:Hemoglobins, Abnormal
vernacular_title: Misura dell'emoglobina glicata sull'analizzatore automatico Abbott IMx.