Role of physiology in the determination of protein heterogeneity.
One of the major problems faced in the manufacture of recombinant proteins is the assessment and control of product heterogeneity, which is caused mainly by the biological variation in post-translational processing. The past year has witnessed significant improvements both in analytical methods for detecting variation in this processing and in our ability to control it.
Jenkins
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Department of Biological Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK. njenkins@dmu.ac.uk
D000596:Amino Acids / Q000737:chemistry; D010450:Endopeptidases / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism*
D000596:Amino Acids; D011994:Recombinant Proteins; D010450:Endopeptidases