[The hormonal characteristics of the pathogenesis of gastric peptic ulcer and duodenal peptic ulcer].
Blood levels of STH, ACTH, somatostatin, bombesin, gastrin, hydrocortisone, aldosterone, testosterone, estradiol, progesterone and gastric juice levels of gastrin and somatostatin were measured in remission and exacerbation of gastric and duodenal ulcer (GU), (DU) using radioimmunoassay. The study included 250 DU, 200 GU and 5O control subjects. As a result, two forms of DU were identified. DU type 1 is characterized by basal and stimulated hypergastrinemia, paradoxical D-cell response to stimulation, high blood concentrations of STH, ACTH, testosterone. Type 2 DU exhibits basal hypogastrinemia, elevated gastrin concentration in response to stimulation, adequate reaction of D-cells, low levels of estradiol and progesterone. In GU there were low concentrations of STH, bombesin, hydrocortisone, estradiol, testosterone, progesterone, somatostatin. D-cell response to loading was adequate. It is concluded that DU and GU pathogeneses are different, that DU is a heterogeneous disease.
Loginov
A S
AS
Arbuzova
V G
VG
Amirov
N Sh
NSh
Astaf'eva
O V
OV
Zvenigorodskaia
L A
LA
D000293:Adolescent; D000328:Adult; D004198:Disease Susceptibility; D004381:Duodenal Ulcer / Q000097:blood* / Q000209:etiology* / Q000628:therapy; D005260:Female; D005750:Gastric Juice / Q000737:chemistry; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012074:Remission Induction; D013276:Stomach Ulcer / Q000097:blood* / Q000209:etiology* / Q000628:therapy
D006728:Hormones
Gormonal'nye osobennosti patogeneza iazvennoĭ bolezni zheludka i iazvennoĭ bolezni dvenadtsatiperstnoĭ kishki.