Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C. Isolation, physico-chemical characterization and biological properties.
During the course of a screening program for inhibitors of myo-inositol monophosphatase we fermented the strain ATCC 20928, a known producer of L-671,776. We now show that this strain produces a complex of at least three sesquiterpenic compounds, L-671,776 (termed factor B) and two structurally related substances, termed factors A and C. Both factors A and C, like L-671,776, exhibited inhibitory activity against myo-inositol monophosphatase. Six other fungi producing the above mentioned compounds were also isolated and taxonomically characterized.
Stefanelli
S
S
Lepetit Research Center, Marion-Merrell Dow Research Institute, Gerenzano (Va), Italy.
Sponga
F
F
Ferrari
P
P
Sottani
C
C
Corti
E
E
Brunati
C
C
Islam
K
K
D001572:Benzofurans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D003904:Mitosporic Fungi / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D013141:Spiro Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013191:Stachybotrys / Q000737:chemistry / Q000145:classification / Q000378:metabolism
D001572:Benzofurans; D003470:Culture Media; D004791:Enzyme Inhibitors; D013141:Spiro Compounds; C077631:L 671776; C088519:Mer NF5003F; C088505:Mer NF5003E; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase