title: Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver.
abstract: 17 beta-estradiol (E2) and progesterone (P) treatment of immature female rats (10 micrograms/100 g body weight) respectively resulted in 1.38-fold (p < 0.02) and 1.42-fold (p < 0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p < 0.001) and 1.43-fold (p < 0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p < 0.05) and a 1.36-fold (p < 0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p < 0.02) and 1.6-fold (p < 0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.
authors.affiliation: Department of Human and Animal Physiology, Faculty of Biology, University of Sofia St. Kliment Ohridski, Bulgaria.
authors.forename: O
authors.initials: O
authors.lastname: Dimitrov
authors.forename: V
authors.initials: V
authors.lastname: Pavlov
authors.forename: I
authors.initials: I
authors.lastname: Jotova
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000097667:Polyamine Oxidase
chemical_list: D006631:Amine Oxidase (Copper-Containing); D004958:Estradiol; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011073:Polyamines; D011374:Progesterone; D011700:Putrescine; D013095:Spermidine; D013096:Spermine; D000097667:Polyamine Oxidase