Association of anti-GM2 antibodies in Guillain-Barré syndrome with acute cytomegalovirus infection.
We examined serum anti-cytomegalovirus (CMV) and anti-ganglioside antibodies by ELISA in 51 patients with Guillain-Barré syndrome (GBS), and titers were compared with those from 47 normal and 74 disease controls. Three GBS patients with IgM anti-CMV antibodies had high titers of IgM and IgG anti-GM2 antibodies. The other GBS patients without IgM anti-CMV antibodies, and the normal and disease controls except one of 6 non-GBS patients with acute CMV infections had no anti-GM2 antibodies. The titers of anti-GM2 antibodies decreased on absorption with CMV-infected cells. These findings suggest that anti-GM2 antibodies are associated with acute CMV infections in GBS patients.
Irie
S
S
Department of Neurology, Kitasato University East Hospital, Kanagawa, Japan.
Saito
T
T
Nakamura
K
K
Kanazawa
N
N
Ogino
M
M
Nukazawa
T
T
Ito
H
H
Tamai
Y
Y
Kowa
H
H
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D002240:Carbohydrate Sequence; D002855:Chromatography, Thin Layer; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005678:G(M2) Ganglioside / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011129:Polyradiculoneuropathy / Q000150:complications / Q000276:immunology* / Q000821:virology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005678:G(M2) Ganglioside