A case of eosinophilic pustular folliculitis (Ofuji's disease) induced by patch and challenge tests with indeloxazine hydrochloride.
A 73-year-old male developed disseminated erythema over his entire body after exposure to indeloxazine hydrochloride, a cerebral activator. Patch testing with indeloxazine hydrochloride showed a positive reaction, and plaques, vesicles and pustules developed on the face after the patch test. These had the pathologic feature of eosinophilic pustular folliculitis (EPF, Ofuji's disease). A challenge test also provoked eruptions on the face, trunk, arms and legs, which were compatible with EPF. Moreover, both the patch and challenge tests with indeloxazine hydrochloride induced eosinophilia. This is the first report of drug allergy-induced EPF, where drug sensitivity induced an abnormal eosinophilic response mimicking EPF.
Kimura
K
K
Department of Dermatology, Tokyo Medical and Dental University, Japan.
Ezoe
K
K
Yokozeki
H
H
Katayama
I
I
Nishioka
K
K
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced / Q000473:pathology; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005499:Folliculitis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D009025:Morpholines / Q000009:adverse effects*; D010328:Patch Tests; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
D000927:Anticonvulsants; D009025:Morpholines; C020852:indeloxazine