title: [Fundamental aspects of osteoinductive activity of bone tissue and potential clinical application].
abstract: Osteoinductive polypeptide factors such as the various isoforms of Bone Morphogenetic Protein described are of increasing scientific and clinical interest because of the great progress in this field of skeletal biology recently achieved. In a review some fundamental chemical and biological aspects of bone and its endogenous osteoinductive activity including isolation and assay of osteoinductive factors are described. Through combination of osteoinductive factors with appropriate carrier materials it seems possible to create osteoinductive implant materials and the results of such investigations and some basic aspects of carrier materials are summarized. The perspectives of the possible clinical applications of such composite are presented.
authors.affiliation: Orthopädische Klinik Paulinenhilfe, Stuttgart.
authors.forename: G
authors.initials: G
authors.lastname: Aldinger
authors.forename: A
authors.initials: A
authors.lastname: Beyer
authors.forename: U
authors.initials: U
authors.lastname: Schmid
authors.forename: G
authors.initials: G
authors.lastname: Herr
mesh_terms: D001672:Biocompatible Materials; D001857:Bone Matrix / Q000378:metabolism; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D007335:Insulin-Like Growth Factor II; D010012:Osteogenesis; D010014:Osteolysis / Q000378:metabolism; D019736:Prostheses and Implants; D011506:Proteins / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; C035170:IGF2 protein, human; D011506:Proteins; D007335:Insulin-Like Growth Factor II
vernacular_title: Grundsätzliche Aspekte der osteoinduktiven Aktivität von Knochengewebe und Möglichkeiten ihrer klinischen Anwendung.