Spectrin: on the path from structure to function.
New structural analyses of the spectrin family of actin cross-linking proteins are providing molecular explanations for both the interchain binding between the alpha and beta chains of spectrin and the intermolecular associations between spectrin and other proteins. Additionally, the analyses bring into focus a conformation which may explain aspects of spectrin's interaction with lipids.
Viel
A
A
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. aviel@harvard.edu
Branton
D
D
D017434:Protein Structure, Tertiary; D013049:Spectrin / Q000737:chemistry* / Q000502:physiology*
D013049:Spectrin