[The immunobiological characteristics of a Salmonella typhimurium strain acquiring a plasmid that controls antibiotic resistance and antibactericidal activity].
The influence of Rdf (resistance defense factor) plasmid inherited by Salmonella typhimurium recipient strain 189, previously deprived of its own virulence plasmid of 60 MD, on the immune status of F1 (CBA x C57BL/6) mice was studied. Experimental infection induced by genetically related pairs of S. typhimurium strains, differing by the presence of Rdf plasmid, revealed the stereotypical character of changes in the number of thymic, splenic, marrow and blood cells with some variations. In mice infected by transconjugant carrying Rdf plasmid immunological shifts were, on the whole, less pronounced than those in the animals infected with clone Rdf.
Chaĭnikova
I N
IN
Smoliagin
A I
AI
Bondarenko
V M
VM
Wu
G
G
Rishchuk
S V
SV
Gritsenko
V A
VA
Mal'shakova
I L
IL
D000818:Animals; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000276:immunology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011815:R Factors / Q000235:genetics / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence / Q000235:genetics / Q000276:immunology
Immunobiologicheskie osobennosti shtamma Salmonella typhimurium, priobretshego plazmidu, kontroliruiushchuiu antibiotikorezistentnost' i antibakteritsidnuiu aktivnost'.