[Reduction of lipoproteins with apoAI but without apoAII (LpAI) in non-insulin-dependent diabetic patients].
Recent data suggest the existence of a relationship between ischemic heart diseases and apolipoprotein A-I containing lipoproteins. The latter and other classic lipid-lipo-protein-apoprotein parameters were quantified in 25 non-insulin-dependent diabetics and 26 normoglycemic normolipidemic subjects. Compared to a control group, non-insulin-dependent diabetics have higher levels of plasma cholesterol (p < 0.05), triacylglycerol, apolipoprotein B (p < 0.001). In contrast, their lipoprotein particles containing only apolipoprotein AI without apolipoprotein AII and apoAI/apoB ratio were lowered (p < 0.001). In our diabetics, apolipoprotein AI was found at normal level but its distribution between high density lipoproteins ('HDL') and 'non-HDL' was abnormal. Also, the distribution of particles containing apolipoprotein A-I without apolipoprotein A-II in non-insulin-dependent diabetics was found abnormal. A higher proportion of both apoAI and LpAI were found in the 'non-HDL' fraction. These data show that lipoprotein metabolism is affected in non-insulin-dependent diabete mellitus. The disease is associated to a lipoprotein profile which is in favour of the atherogenic process.
Barkia
A
A
Ecole supérieure des sciences et techniques de la santé, Sfax, Tunisie.
Zouari
N
N
Khrouf
W
W
Ellouz
F
F
Zouaghi
H
H
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood* / Q000737:chemistry; D016633:Apolipoprotein A-II / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000737:chemistry; D008297:Male; D008875:Middle Aged
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001055:Apolipoproteins B; D008075:Lipoproteins, HDL
Réduction des lipoprotéines avec apoAI mais sans apoAII (LpAI) chez les diabétiques non insulino-dépendants.