title: Tumor markers and lung cancer: guidelines in a cost-limited medical organization.
abstract: The aim of our study was to evaluate the cost of the tumor marker assays most widely used in pneumological practice and the effectiveness of the percentage of DRG-based reimbursements absorbed by these assays. For this purpose we assessed the cost of lung tumor marker assays in Emilia Romagna compared to the DRG-based reimbursement of inpatients affected by lung diseases in whom the use of tumor markers is indicated. As an example, we evaluated the cost/effectiveness of the CEA assay in the differential diagnosis of 68 pleural effusions from 46 patients (20 benign diseases, 26 malignant). Because the CEA assay was not a substitute for cytology when this was not diagnostic, 41.3% of the resources were not efficiently spent. If the marker assay had been performed only in cases with negative cytology, we could have spared 14 of 46 tests. Moreover, since the expense lies predominantly in the cost of reagents (81.23%), we suggest as a routine procedure to collect and store samples for tumor marker assay in all cases; the test should be performed in a selected population of patients with negative cytology and "suspect" clinical outcome.
authors.affiliation: Pneumological Division, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Falcone
authors.forename: M
authors.initials: M
authors.lastname: Marinelli
authors.forename: L
authors.initials: L
authors.lastname: Minguzzi
authors.forename: G M
authors.initials: GM
authors.lastname: Paganelli
authors.forename: E
authors.initials: E
authors.lastname: Turba
authors.forename: A
authors.initials: A
authors.lastname: Cavalli
authors.forename: M
authors.initials: M
authors.lastname: Rapellino
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis / Q000191:economics; D014408:Biomarkers, Tumor / Q000191:economics*; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000191:economics; D003937:Diagnosis, Differential; D003953:Diagnosis-Related Groups; D006287:Health Planning Guidelines; D006801:Humans; D007558:Italy; D007633:Keratins / Q000032:analysis / Q000191:economics; D008175:Lung Neoplasms / Q000175:diagnosis*; D010996:Pleural Effusion / Q000175:diagnosis; D011445:Prospective Payment System; D011933:Reagent Kits, Diagnostic / Q000191:economics; D015843:Serpins; D019396:Tissue Polypeptide Antigen / Q000032:analysis / Q000191:economics
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D011933:Reagent Kits, Diagnostic; D015843:Serpins; D019396:Tissue Polypeptide Antigen; C051072:squamous cell carcinoma-related antigen; D007633:Keratins