A clinical study of minocycline-induced pneumonitis.
We studied the clinical features of minocycline-induced pneumonitis in seven patients. Acute symptoms included fever, dry cough and dyspnea, indicating acute respiratory failure. Diffuse ground glass shadows with Kerley's B lines, bronchial wall thickening, swelling of vascular bundles and pleural effusion were visible on radiography. Bronchoalveolar lavage or transbronchial lung biopsy confirmed pulmonary eosinophilia. Cessation of minocycline led to rapid remission with no treatment or only short-term steroid therapy. The lymphocyte stimulation test for minocycline with peripheral blood lymphocytes was not found to be useful for diagnosis.
Toyoshima
M
M
Department of Internal Medicine, Hamamatsu University School of Medicine.
Sato
A
A
Hayakawa
H
H
Taniguchi
M
M
Imokawa
S
S
Chida
K
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000542:Alveolitis, Extrinsic Allergic / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001706:Biopsy; D001784:Blood Gas Analysis; D018893:Bronchoalveolar Lavage; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D010612:Pharyngitis / Q000150:complications / Q000188:drug therapy; D011657:Pulmonary Eosinophilia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D007073:Immunoglobulin E; D002097:C-Reactive Protein; D008911:Minocycline