Severe hyperchloriduria-hyperkaliuria: a new congenital renal tubular abnormality?
A female infant, aged 5 weeks, had metabolic alkalosis associated with severe electrolyte disturbances. In addition to findings typically seen in patients with Bartter syndrome or hyperprostaglandin E syndrome, she had massive urinary excretion of prostaglandins E2 and E-M, normal calcium metabolism, hyperphosphaturia, and severe hyperchloriduria and hyperkaliuria with limited response to indomethacin. These findings may represent a new congenital renal tubular abnormality.
Meyburg
J
J
University Children's Hospital, Heidelberg, Germany.
Mayatepek
E
E
Hoffmann
G F
GF
Linderkamp
O
O
Seyberth
H W
HW
D001477:Bartter Syndrome / Q000175:diagnosis; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000652:urine*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D015232:Dinoprostone / Q000652:urine; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007223:Infant; D011188:Potassium / Q000652:urine*; D011453:Prostaglandins / Q000652:urine; D015499:Renal Tubular Transport, Inborn Errors / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000652:urine; D013577:Syndrome
D002712:Chlorides; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; C060526:7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid; D015232:Dinoprostone; D011188:Potassium; D002118:Calcium; D007213:Indomethacin