[The secretory function of the gastric glands under the joint action of acetylcholine, adenosine triphosphoric acid and histamine].
The combined action of acetylcholine (in a dose of 0.5 mg/kg), ATP (0.5 mg/kg) and histamine (0.05 mg/kg) on the secretory function of the gastric glands has been studied. Combined action of acetylcholine and histamine has induced an increase in the secretion volume rate, acid producing and pepsin discharge functions of the gastric glands. The ATP effect of the background of histamine-stimulated secretion increased acid production and pepsin discharge but less than acetylcholine and histamine did. Simultaneous action of acetylcholine, ATP and histamine has led to potentiation of acetylcholine and ATP effects of the volumetric secretory rate and to their summarized action on pepsin discharge. The conclusion is made that activation of the secretory processes with simultaneous action of the above-mentioned mediatory substances is associated with the participation of corresponding intracellular secondary messengers and start of some cascade reactions.
Skliarov
O Ia
OIa
D000109:Acetylcholine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010434:Pepsin A / Q000187:drug effects / Q000378:metabolism; D015290:Second Messenger Systems / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors
D018377:Neurotransmitter Agents; D006632:Histamine; D000255:Adenosine Triphosphate; D010434:Pepsin A; D000109:Acetylcholine
Sekretorna funktsiia shlunkovykh zaloz pry spil'niĭ diï atsetylkholinu, adenozyntryfosfornoï kysloty ta histaminu.