Potassium channel blockade does not alter the modulatory effects of dopamine in neostriatal slices.
This study assessed the contribution of K+ conductances to dopamine (DA)-induced modulation of evoked depolarizing synaptic responses (DPSPs) in neostriatal slices obtained from rats. Intracellular recordings of membrane properties and DPSPs evoked by local electrical stimulation were obtained from cells bathed in standard artificial cerebrospinal fluid (ACSF), 5 mM Cs+ in ACSF, 20 mM tetraethylammonium in ACSF, or 1 mM 4-aminopyridine in ACSF. DA altered response amplitude in approximately equal proportions regardless of the presence or absence of these K(+)-channel blockers. These findings suggest that K+ conductances do not provide a major contribution to DA-induced changes in DPSPs in the neostriatum.
Altemus
K L
KL
Mental Retardation Research Center, University of California, Los Angeles 90024-1759, USA.
Levine
M S
MS
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D015640:Ion Channel Gating / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
D015221:Potassium Channels; D004298:Dopamine