Novel monoacetoneglucose derivatives with calcium antagonist activity.
Ethers and thioethers of monosaccharides have been synthesised which show potent toxicity to mouse (LD50 > or = 4 g.kg-1 O.W. and 0.2 to 1.5 g.kg-1 I.P.W.). A study of calcium antagonist activity for the full series of compounds indicated that the activity was similar for both O- and S- ethers and maximum activities were observed for monoacetoneglucose ethers possessing carbon chain close to 8 carbons.
Bécaert
T
T
Laboratoire de Neurobiologie Cellulaire, Faculté des Sciences-Université de Picardie Jules Verne, Amiens, France.
Vanlemmens
P
P
Villa
P
P
Lahyani
A
A
Lehouelleur
J
J
Postel
D
D
Ronco
G
G
Brulé
G
G
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004386:Duodenum / Q000187:drug effects; D005947:Glucose / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats
D002121:Calcium Channel Blockers; D005947:Glucose