Spontaneous pregnancies despite failed attempts at ovulation induction in a woman with latrogenic premature ovarian failure.
BACKGROUND
Women with premature ovarian failure may conceive spontaneously or following different regimens of ovulation induction.


METHODS
A 29-year-old woman with eight years of hypergonadotropic hypogonadism following chemotherapy and radiotherapy for Hodgkin's disease conceived spontaneously and spontaneously aborted after discontinuation of estrogen replacement. Subsequently she underwent pituitary gonadotrope downregulation and attempted controlled ovarian hyperstimulation without an ovarian response or follicular development. Despite this failure, she conceived spontaneously on two occasions, resulting in a live-born infant and an ongoing pregnancy.


CONCLUSIONS
Cases of hypergonadotropic hypogonadism may not be permanent or irreversible. Interventional regimens may fail to induce ovulation despite the presence of residual oocytes capable of recruitment and fertilization.
Menashe
Y
Y
Department of Obstetrics and Gynecology, Ceders-Sinai Medical Center, University of California-Los Angeles, School of Medicine, USA.
Pearlstone
A C
AC
Surrey
E S
ES
D000328:Adult; D004359:Drug Therapy, Combination; D015914:Estrogen Replacement Therapy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced / Q000188:drug therapy*; D017211:Treatment Failure