title: Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging.
abstract: We studied 10 medically intractable temporal lobe epilepsy (TLE) patients prior to surgery using proton magnetic resonance spectroscopic imaging (MRSI) to localize seizure foci. We found significantly elevated creatine/N-acetylaspartate (Cr/NAA) unilaterally in 8 and bilaterally in 2 patients. Five patients have been studied again 1 year after surgery. In the 2 patients with bilateral temporal seizure onsets, MRSI showed normalization of Cr/NAA in the unoperated contralateral tissue following surgical elimination of seizures. This study suggests that metabolic recovery can occur in contralateral temporal areas following surgical treatment of partial epilepsy.
authors.affiliation: UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham 35294-0021, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Hugg
authors.forename: R I
authors.initials: RI
authors.lastname: Kuzniecky
authors.forename: F G
authors.initials: FG
authors.lastname: Gilliam
authors.forename: R B
authors.initials: RB
authors.lastname: Morawetz
authors.forename: R E
authors.initials: RE
authors.lastname: Fraught
authors.forename: H P
authors.initials: HP
authors.lastname: Hetherington
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D013702:Temporal Lobe / Q000378:metabolism / Q000601:surgery*
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003404:Creatinine