title: Eradication of aortic infections with the use of cryopreserved arterial homografts.
abstract: BACKGROUND
  The surgical treatment of vascular infection is associated with a substantial early and late mortality. Cryopreserved homografts were evaluated for in situ reconstruction in aortic infections.
  
  
  METHODS
  Between January 1991 and July 1995, homografts were used in 19 patients (mean age, 61 +/- 13 years; range, 40-85 years) with mycotic aneurysms (9/19; 47%) or infected grafts (10/19; 53%) in the thoracic (7/19; 37%) or abdominal (12/19; 63%) aorta. Sepsis was present preoperatively in 14 of 19 (74%) patients, and 18 of 19 (95%) had received antibiotic treatment for 6.4 +/- 6 months (range, 1-36 months). Up to ten previous vascular procedures had been done in 11 of 19 patients (58%).
  
  
  RESULTS
  There was one (5.2%) early and two (11%) late deaths, with one (5.5%) of the late deaths being homograft related. The mean hospital stay was 27 +/- 26 days (range, 7-84 days). Antibiotics were given postoperatively for 30 +/- 12 days (range, 4-84 days). During the follow-up period of 18.6 +/- 13 months (range, 7-60 months), there were no instances of reinfection, suture line rupture, homograft stenosis, or anastomotic aneurysms.
  
  
  CONCLUSIONS
  Cryopreserved arterial homografts allow safe in situ reconstruction, decrease early and midterm mortality, and reduce antibiotic requirements. Early and midterm reoperations are unnecessary.
authors.affiliation: Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland.
authors.forename: P R
authors.initials: PR
authors.lastname: Vogt
authors.forename: L K
authors.initials: LK
authors.lastname: von Segesser
authors.forename: Y
authors.initials: Y
authors.lastname: Goffin
authors.forename: U
authors.initials: U
authors.lastname: Niederhäuser
authors.forename: M
authors.initials: M
authors.lastname: Genoni
authors.forename: A
authors.initials: A
authors.lastname: Künzli
authors.forename: M
authors.initials: M
authors.lastname: Lachat
authors.forename: M I
authors.initials: MI
authors.lastname: Turina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000785:Aneurysm, Infected / Q000601:surgery*; D019072:Antibiotic Prophylaxis; D001014:Aortic Aneurysm / Q000601:surgery*; D001018:Aortic Diseases / Q000601:surgery*; D001158:Arteries / Q000637:transplantation*; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications; D016459:Prosthesis-Related Infections / Q000601:surgery*; D012008:Recurrence
chemical_list: D011093:Polyethylene Terephthalates