Expression of protein tyrosine kinases in the murine thymus stroma.
Thymocytes not only receive signals from thymic epithelial cells but can also activate the latter, at least in the medulla. We have previously reported tyrosine phosphorylation of medullary epithelial cell substrates, after co-culture with thymocytes, and identified a number of protein tyrosine kinases in a line of thymic epithelial cells. We report here the in situ localisation by immunohistochemistry of JAK2 in medullary epithelial cells, of PDGF-R in medullary vascular endothelium, of FGF-R in Hassall's corpuscles, and the weak expression of JAK1 and RYK throughout the thymus.
Potworowski
E F
EF
Institute Armand-Frappier, Laval, QC, Canada.
Beauchemin
C
C
D000595:Amino Acid Sequence; D000818:Animals; D018858:Germinal Center / Q000201:enzymology; D007150:Immunohistochemistry; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis*; D011518:Proto-Oncogene Proteins; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis; D017479:Receptors, Platelet-Derived Growth Factor / Q000096:biosynthesis; D017154:Stromal Cells / Q000201:enzymology*; D013950:Thymus Gland / Q000201:enzymology*
D011518:Proto-Oncogene Proteins; D017468:Receptors, Fibroblast Growth Factor; D011505:Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor; C507905:Jak1 protein, mouse; C507926:Jak2 protein, mouse; D053613:Janus Kinase 1; D053614:Janus Kinase 2