Protein profiling of the myocardium exposed to pressure overload from birth.
Aortic banding induced in 2-day-old (A2) and 6-day-old (A6) male rats increased the left ventricular (LV) weight after 60 days; right ventricular (RV) enlargement occurred in the A2 group only. The concentration of collagenous proteins in the LV was elevated in both experimental groups (more in the A2 rats) at the expenses of sarcoplasmic proteins. Aortic banding also affected the proportion of collagen types (lower collagen I, higher collagen III, V) and myosin light chains (higher LC1/LC2) in the LV. Similar changes of proteins in the RV were less pronounced.
Cernohorsky
J
J
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Pelouch
V
V
Milerová
M
M
Ostádal
B
B
D000818:Animals; D000831:Animals, Newborn; D001011:Aorta / Q000601:surgery; D003094:Collagen / Q000032:analysis*; D006321:Heart / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D018994:Myosin Light Chains / Q000032:analysis; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000737:chemistry
D018994:Myosin Light Chains; D003094:Collagen