Localization of the gene encoding the human L-glutamate transporter (GLT-1) to 11p11.2-p13 by fluorescence in situ hybridization.
High affinity glutamate transporters regulate levels of extracellular glutamate in the central nervous system. Impaired glutamate transport has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). The glutamate transporter subtypes GluT-1 and EAAC1 have previously been mapped to human chromosomes 5p13 and 9p24, respectively. In the present study, the GLT-1 subtype was mapped to human chromosome 11p11.2-p13 by fluorescence in situ hybridization. The possible clinical implications of this finding are discussed.
Takai
S
S
Department of Genetics, Research Institute, International Medical Center of Japan, Tokyo.
Kawakami
H
H
Nakayama
T
T
Yamada
K
K
Nakamura
S
S
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D027322:Amino Acid Transport System X-AG; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D017404:In Situ Hybridization, Fluorescence
D018528:ATP-Binding Cassette Transporters; D027322:Amino Acid Transport System X-AG