title: Parvovirus B19 infection and idiopathic thrombocytopenic purpura.
abstract: The potential association of human parvovirus B19 infection with idiopathic thrombocytopenic purpura (ITP) was studied. All 60 adult patients presenting with ITP at the University Hospital Rotterdam - Dijkzigt during a 12-year period (41 with acute ITP, 19 with chronic ITP) were included. Patient files were retrospectively analyzed. Stored serum samples were tested for parvovirus B19-specific IgG and IgM anti-bodies, and for parvovirus B19 DNA. In only one patient (1.7%) was evidence of recent B19 infection found. Parvovirus B19 is not a frequent cause of adult ITP and should be tested for only when there are other indications of possible parvovirus B19 involvement.
authors.affiliation: Department of Virology, University Hospital, Leiden, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: van Elsacker-Niele
authors.forename: H T
authors.initials: HT
authors.lastname: Weiland
authors.forename: A C
authors.initials: AC
authors.lastname: Kroes
authors.forename: M C
authors.initials: MC
authors.lastname: Kappers-Klunne
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000276:immunology / Q000821:virology*; D012189:Retrospective Studies
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M