[The effect of low-sodium media on pepsinogen extrusion by dispersed gastric glands].
It is found that the dependence of pepsinogen extrusion by the dispersed gastric glands in Na+ concentration in the incubation medium is of the cupola-shaped character with a maximum at 20-40 mmole/l. In the calcium-free medium which contained EGTA (0.25 mmole/l) and in the presence of Ca antagonists (La3+, Co2+, Cd2+, Mn2+) the pepsinogen extrusion induced by low Na+ concentrations was suppressed. The obtained results confirm the functioning of the Na/Ca-exchange system in the plasma membranes of chief gastric gland cells. This system is able to support physiologically important changes in concentrations of intracellular calcium in response to changes in the transmembrane Na+ gradient.
Dubyts'kyĭ
L O
LO
Sabadash
H I
HI
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D010435:Pepsinogens / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism*
D002121:Calcium Channel Blockers; D002614:Chelating Agents; D003470:Culture Media; D010435:Pepsinogens; D004533:Egtazic Acid; D012964:Sodium; D010447:Peptide Hydrolases; D002118:Calcium
Vplyv hiponatriievykh seredovyshch na ekstruziiu pepsynohenu dysperhovanymy zalozamy shlunka.