title: Early lung allograft function in twin recipients from the same donor: risk factor analysis.
abstract: BACKGROUND
  Transplantation of lung allografts from the same donor into 2 recipients ("twinning") provides an opportunity to study recipient and donor factors that influence early allograft function.
  
  
  METHODS
  Twenty-seven pairs of recipients were identified and evaluated using multivariate logistic regression analysis (p < 0.05). Four measures of early graft function were analyzed: alveolar-arterial gradient in the operating room, first alveolar-arterial gradient in the intensive care unit, alveolar-arterial gradient at 24 hours, and days of mechanical ventilation.
  
  
  RESULTS
  Analysis of the pooled data without regard to pairing showed that alveolar-arterial gradient in the operating room was influenced by donor age, length of donor hospitalization, recipient mean pulmonary artery (PA) pressure at unclamping, and transplantation of a left lung. The alveolar-arterial gradient in the intensive care unit was correlated with donor age, donor cause of death, and mean PA pressure on arrival in that unit. Only mean PA pressure remained significant at 24 hours. Days of mechanical ventilation was determined by mean PA pressure on arrival in the intensive care unit, drop in mean PA pressure during operation, and diagnosis of the recipient. In the paired analysis, receiving a left lung, recipient diagnosis (pulmonary hypertension worse than others), and need of cardiopulmonary bypass were significantly associated with immediate graft dysfunction, although these influences did not persist beyond the immediate postoperative period. Donor arterial oxygen tension and time of ischemia were not significant predictors in any analysis.
  
  
  CONCLUSIONS
  Immediate allograft function was associated with donor-related characteristics initially, but these lost importance over the ensuing 24 hours. Recipient PA pressure was an immediate and persisting influence. In the analysis of differences in function between the members of each pair, transplantation of the left lung, recipient diagnosis, and cardiopulmonary bypass were identified, but their influence did not persist beyond the first 6 hours.
authors.affiliation: Division of Cardiothoracic Surgery, University of Pittsburgh, PA 15213-3221, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Sommers
authors.forename: B P
authors.initials: BP
authors.lastname: Griffith
authors.forename: R L
authors.initials: RL
authors.lastname: Hardesty
authors.forename: R J
authors.initials: RJ
authors.lastname: Keenan
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D005260:Female; D006085:Graft Survival; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000502:physiology; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010100:Oxygen / Q000097:blood; D011651:Pulmonary Artery / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D010100:Oxygen