Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury.
Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, are the most commonly used medications worldwide. They are effective analgesic and anti-inflammatory agents. A major drawback to their use is a high frequency of adverse gastrointestinal (GI) effects that cause significant morbidity, occasional mortality, and substantial increases in cost of therapy. In this review, mechanisms of NSAID-induced GI injury are presented, and a clinical approach to diagnosis, treatment, and prevention of these adverse GI effects is provided.
Bjorkman
D J
DJ
Division of Gastroenterology, University of Utah School of Medicine, Salt Lake City, USA.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D008329:Managed Care Programs; D014456:Ulcer / Q000139:chemically induced; D014481:United States
D000894:Anti-Inflammatory Agents, Non-Steroidal