title: [Three siblings with interstitial pneumonia].
abstract: Patient 1: A 64-year-old woman was admitted for further examination after reticulonodular shadows were found on a chest X-ray film. Idiopathic interstitial pneumonia (IIP) was diagnosed. Patient 2: The 60-year-old sister of patient 1 was admitted for further examination after reticulonodular shadows were found on a chest X-ray film. IIP was diagnosed. About half a year later, her proximal interphalangeal joints had become swollen and the result of a rheumatoid hemagglutination test was positive. Therefore, the pneumonia was suspected to have been caused by a collagen-vascular disease (CVD), rheumatoid arthritis. Patient 3: The 64-year-old brother of patient 1 was examined. A chest X-ray film revealed reticulonodular shadows that were strongly suggestive of IIP. The remaining three siblings were examined. In a 62-year-old sister, the chest X-ray film was normal, but the level of anti-nuclear antigen was elevated. The fact that the level of this antigen was high in these four siblings and that the 60-year-old sister later suffered from rheumatoid arthritis suggested the presence of a factor predisposing to CVD in these siblings. The interstitial pneumonia in these siblings may have been related to CVD.
authors.affiliation: First Department of Medicine, Hokkaido University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohe
authors.forename: M
authors.initials: M
authors.lastname: Munakata
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Sukoh
authors.forename: H
authors.initials: H
authors.lastname: Takekawa
authors.forename: E
authors.initials: E
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Homma
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000235:genetics; D003095:Collagen Diseases / Q000150:complications / Q000235:genetics; D005260:Female; D006680:HLA Antigens; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D010375:Pedigree
chemical_list: D006680:HLA Antigens