title: Role of HLA class II alleles in Korean patients with IDDM.
abstract: MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1*0301 and DQA1*0501 were positively and DQA1*0102 and DQA1*0201 negatively associated with IDDM. DQB1*0301 and DQB1*0601 were negatively associated with IDDM. Heterodimers DQA1*0301-DQB1*0201, DQA1*0501-DQB1*0201 and DQA1*0501-DQB1*0302 were positively associated with DQA1*0102-DQB1*0601 negatively associated with IDDM. The frequencies of DR3-DQA1*0301-DQB1*0201 and -DQA1*0501-DQB1*0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1*0301-DQB1*0201 and DR9-DQA1*0301-DQB1*0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQ beta-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.
authors.affiliation: Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Ikegami
authors.forename: T
authors.initials: T
authors.lastname: Fujisawa
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Chung
authors.forename: J O
authors.initials: JO
authors.lastname: Park
authors.forename: E J
authors.initials: EJ
authors.lastname: Lee
authors.forename: S K
authors.initials: SK
authors.lastname: Lim
authors.forename: K R
authors.initials: KR
authors.lastname: Kim
authors.forename: K B
authors.initials: KB
authors.lastname: Huh
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Fugisawa
mesh_terms: D000328:Adult; D000483:Alleles; D001120:Arginine; D001224:Aspartic Acid; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility; D005802:Genes, MHC Class II; D014644:Genetic Variation; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D007723:Korea; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D001224:Aspartic Acid; D001120:Arginine