The role of free oxygen radicals in children with chronic viral hepatitis B.
Lipid peroxidation of polyunsaturated fatty acids, being important components of cellular membranes, caused by free oxygen radicals is considered to be one of the main causes of hepatocyte injury. The aim of this study is to estimate the malondialdehyde (MDA) level in the red blood cells of children with chronic viral hepatitis B. The decrease of MDA concentration along with the clinical and serological improvement in children with chronic hepatitis B was observed. We also noticed a correlation of MDA with HBeAg-anti HBe seroconversion and obliteration of HBV DNA polimerase activity.
Lebensztejn
D M
DM
Third Department of Pediatrics, Medical Academy of Białystok.
Chwiećko
M
M
Semeniuk
J
J
Kaczmarski
M
M
Farbiszewski
R
R
D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004912:Erythrocytes / Q000737:chemistry; D006509:Hepatitis B / Q000503:physiopathology*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood
D008315:Malondialdehyde