Collagen-encapsulated coagulation necrosis in cerebral infarcts: a pathological study.
Coagulation necrosis (CN)--a type of necrosis characterized by firm, eosinophilic parenchyma with recognizable cell outlines--is thought to be a result of rapid degeneration of tissue protein to a gel state and loss of water which prevents the necrotic tissue from undergoing autolysis and cellular digestion. In this study, we observed CN in cerebral infarcts of 11 of 150 consecutive autopsy cases of large cerebral infarction. Cerebral CN in patients who had survived for about 1 month had already started to be surrounded by newly formed vessels and type I collagen-positive tissue. In patients who had survived for more than 1 year, CN was deposited with calcium and cholesterin crystals and encapsulated by thick, dense collagenous tissue. Encapsulation, however, was not always complete, a finding that suggests that other factors, such as gel transformation at an early stage of CN and calcification at a later stage, are important for the persistence of CN in the infarct. The results of our study suggest that cerebral CN occurs more frequently than is generally believed.
Yamazaki
M
M
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan.
Nakano
I
I
Morimatsu
Y
Y
Oda
M
M
Machinami
R
R
Mizutani
T
T
D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000378:metabolism / Q000473:pathology*; D002544:Cerebral Infarction / Q000378:metabolism / Q000473:pathology*; D003094:Collagen; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis
D003094:Collagen