title: Non-steroidal anti-inflammatory drugs and variceal bleeding: a case-control study.
abstract: OBJECTIVE
  The aim of this case-control study was to assess the risk of bleeding from esophageal varices associated with aspirin and non-steroidal anti-inflammatory drug consumption.
  
  
  METHODS
  Between January 1992 and May 1994, patients admitted for bleeding from esophageal or gastric lesions related to portal hypertension were matched with a control patient of the same age and sex, who was free of gastrointestinal bleeding. A structured interview was conducted with the cases and controls to determine drug consumption during the 2 weeks preceding admission. Fifty-nine cases and 59 controls were recruited.
  
  
  CONCLUSIONS
  Use of aspirin was more prevalent among the cases than the controls (odds ratio 3.81; 95% confidence interval 1.36-11.64; p = 0.004). This difference remained significant in the subgroups of patients with a first episode of variceal bleeding (odds ratio 3.9; 95% confidence interval 1.2-13.9, p = 0.01), but was not significant in the subgroups of patients with a recurrent episode of variceal bleeding. The use of aspirin was associated with a high risk of a first episode of variceal bleeding, suggesting that patients with portal hypertension should avoid taking these drugs.
authors.affiliation: Service d'Hepatologie, Centre Hospitalier Universitaire, Poitiers, France.
authors.forename: V
authors.initials: V
authors.lastname: de Lédinghen
authors.forename: P R
authors.initials: PR
authors.lastname: Mannant
authors.forename: J
authors.initials: J
authors.lastname: Foucher
authors.forename: M C
authors.initials: MC
authors.lastname: Perault
authors.forename: T
authors.initials: T
authors.lastname: Barrioz
authors.forename: P
authors.initials: P
authors.lastname: Ingrand
authors.forename: B
authors.initials: B
authors.lastname: Vandel
authors.forename: C
authors.initials: C
authors.lastname: Silvain
authors.forename: M
authors.initials: M
authors.lastname: Beauchant
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D016022:Case-Control Studies; D004932:Esophageal and Gastric Varices / Q000209:etiology*; D005069:Evaluation Studies as Topic; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin