title: Does age at cochlear implantation affect the distribution of 2-deoxyglucose label in cat inferior colliculus?
abstract: Cochlear implants are one treatment for children who are born deaf or become deaf before acquiring language. The question of optimum age for implantation arises. Using an animal model, we have studied the response of the auditory brainstem to implantation at various ages. Neonatally, pharmacologically deafened cats were implanted with a 4-electrode array in the left cochlea at ages from 100 to over 180 days. Eleven were chronically stimulated (1000 h if possible) with charge-balanced, biphasic current pulses; eight were unstimulated controls. In a terminal experiment, each animal received [14C]2-deoxyglucose i.v. preceding a 45-min stimulation program. The fraction of the right inferior colliculus (IC) with a significant accumulation of label was calculated. If age at implantation were a significant factor in determining the size of the responding region, the fraction would depend on the age; this was not observed. However, there was considerable variation in the IC fraction sizes within both stimulated and unstimulated groups, leading to the conclusion that there are factors other than age which determine the size of the responding region. Thus, for deaf children of corresponding ages, age at implantation may not be of critical importance.
authors.affiliation: Department of Otolaryngology, University of Melbourne, Victoria, Australia. SELDONL@mail.medoto.unimelb.edu.au
authors.forename: H L
authors.initials: HL
authors.lastname: Seldon
authors.forename: A
authors.initials: A
authors.lastname: Kawano
authors.forename: G M
authors.initials: GM
authors.lastname: Clark
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D002415:Cats; D003054:Cochlear Implants; D003638:Deafness / Q000139:chemically induced / Q000628:therapy*; D003847:Deoxyglucose / Q000378:metabolism*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D007245:Inferior Colliculi / Q000378:metabolism*; D007553:Isotope Labeling; D009473:Neuronal Plasticity / Q000502:physiology
chemical_list: D002250:Carbon Radioisotopes; D003847:Deoxyglucose