[Toxic retinopathy caused by intravitreal injection of amikacin and vancomycin].
METHODS
Referred because of a right corneal perforation with cellular reaction in anterior chamber, a patient was sutured and treated with a single intravitreal injection of 0.2 ml (1 mg) Amikacin and 0.2 ml (1 mg) Vancomycin. Whereas the retina was normal before the injection, a diffuse retinal edema with intra- and preretinal hemorrhages was noted 12 hours postoperatively. Visual acuity was markedly reduced. ERG and visual field was also abnormal.


CONCLUSIONS
This case demonstrates that a single intravitreal injection of Amikacin and Vancomycin at usual concentration may induce retinal toxicity with permanent damage.
Piguet
B
B
Service Universitaire d'Ophtalmologie, Hôpital Jules Gonin, Lausanne.
Chobaz
C
C
Grounauer
P A
PA
D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D065306:Corneal Injuries; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use; D015807:Eye Injuries, Penetrating / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000139:chemically induced*; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects*; D014822:Vitreous Body / Q000187:drug effects
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D000583:Amikacin
Rétinopathie toxique sur injection intravitréenne d'Amikacine et Vancomycine.