Anti-inflammatory and anti-nociceptive activity of disodium glycyrrhetinic acid hemiphthalate.
The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3 beta-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the rat paw edema induced by carrageenin (ID50 = 21.37 mg/kg), and mice writhing responses caused by acetic acid (ID50 = 9.12 mg/kg). The potency of disodium glycyrrhetinic acid hemiphthalate was about 13.05 times higher than acetylsalicylic acid in inhibiting rat paw edema and 12.84 times higher in inhibiting abdominal constrictions in mice.
Khaksa
G
G
Pharmaceutical Research Center Darou Pakhsh Co., Tehran, Iran.
Zolfaghari
M E
ME
Dehpour
A R
AR
Samadian
T
T
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D004487:Edema; D005260:Female; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D008297:Male; D051379:Mice; D010146:Pain; D010936:Plant Extracts; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid; D001241:Aspirin