Dopamine D3 agonists disrupt social behavior in rats.
Behavioral studies were conducted in rats administered a selective D3 agonist, 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) or 4aR, 10bR-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1] benzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). Both drugs induced disruption of huddling behavior in rats at doses that did not produce hyperlocomotion. The effects of the D3 agonists were dependent upon dosage and time after administration. These results suggest that D3 receptors are concerned with social interaction in rats.
Kagaya
T
T
Eisai Tsukuba Research Laboratories, Ibaraki, Japan.
Yonaga
M
M
Furuya
Y
Y
Hashimoto
T
T
Kuroki
J
J
Nishizawa
Y
Y
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D002478:Cells, Cultured; D018491:Dopamine Agonists / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010078:Oxazines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000819:agonists* / Q000378:metabolism; D050637:Receptors, Dopamine D3; D012919:Social Behavior; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D001578:Benzopyrans; D018491:Dopamine Agonists; C493595:Drd3 protein, rat; D010078:Oxazines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; C062458:3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol; C031349:7-hydroxy-2-N,N-dipropylaminotetralin