Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat.
The existence of adrenomedullin (AM) in the rat hypothalamus was examined by immunohistochemistry. AM-immunoreactive neurons were found in the supraoptic nucleus (SON) and in the magnocellular parts of the paraventricular nucleus (PVN). The co-existence of AM-, oxytocin- and/or vasopressin-immunoreactivity was identified in the same neurons in the hypothalamus. The results suggest that the AM may play a role in neurotransmission or in cardiovascular control with neurohypophyseal hormones.
Ueta
Y
Y
Department of Physiology, University of Occupational and Environmental Health, Kitakyushu City, Japan.
Kitamura
K
K
Isse
T
T
Shibuya
I
I
Kabashima
N
N
Yamamoto
S
S
Kangawa
K
K
Matsuo
H
H
Eto
T
T
Yamashita
H
H
D053607:Adrenomedullin; D000818:Animals; D000918:Antibody Specificity; D000959:Antihypertensive Agents / Q000032:analysis / Q000276:immunology*; D007150:Immunohistochemistry; D008297:Male; D010121:Oxytocin / Q000032:analysis; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry*; D010455:Peptides / Q000032:analysis / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013495:Supraoptic Nucleus / Q000737:chemistry; D014667:Vasopressins / Q000032:analysis
D000959:Antihypertensive Agents; D010455:Peptides; D014667:Vasopressins; D053607:Adrenomedullin; D010121:Oxytocin