title: [The effect of calponin on the rate of actin filament movement].
abstract: The effect of calponin on the velocity of actin filaments sliding over skeletal and phosphorylated smooth myosins was studied by in vitro mobility assay. It was found that calponin, being part of an actin filament, inhibits the average velocity of thin filaments movement. The analysis of histograms of the velocities showed that in the presence of calponin, actin filaments are capable to slow down the sliding, stop moving and move with high velocity, characteristic of calponin-free filaments. Tropomyosin weakens the inhibiting effect of calponin. It is supposed that calponin inhibits the sliding of thin filaments in more "all or none" fashion.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Borovikov
authors.forename: K Y
authors.initials: KY
authors.lastname: Horiuchi
authors.forename: S
authors.initials: S
authors.lastname: Chacko
mesh_terms: D000199:Actins / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002148:Calmodulin-Binding Proteins / Q000494:pharmacology*; D002645:Chickens; D008840:Microfilament Proteins; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009218:Myosins / Q000187:drug effects / Q000502:physiology; D014335:Tropomyosin / Q000494:pharmacology; D000096985:Calponins
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D002148:Calmodulin-Binding Proteins; D008840:Microfilament Proteins; D009218:Myosins; D014335:Tropomyosin; D000096985:Calponins
vernacular_title: Vliianie kal'ponina na skorost' dvizheniia aktinovykh niteĭ.