title: Regulation of cathepsin E expression during human B cell differentiation in vitro.
abstract: Cathepsin E is an aspartic proteinase which has been implicated in antigen processing in the class II major histocompatibility complex pathway. In this study we show that cathepsin E, measured at both the protein and message level, is up-regulated late in human B cell activation. The implications of this observation in terms of cathepsin E function are discussed.
authors.affiliation: Department of Immunology, UCL Medical School, London, GB.
authors.forename: L
authors.initials: L
authors.lastname: Sealy
authors.forename: F
authors.initials: F
authors.lastname: Mota
authors.forename: N
authors.initials: N
authors.lastname: Rayment
authors.forename: P
authors.initials: P
authors.lastname: Tatnell
authors.forename: J
authors.initials: J
authors.lastname: Kay
authors.forename: B
authors.initials: B
authors.lastname: Chain
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D001483:Base Sequence; D020059:Cathepsin E; D002403:Cathepsins / Q000096:biosynthesis* / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D014066:Palatine Tonsil; D012333:RNA, Messenger / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000939:Epitopes; D012333:RNA, Messenger; D002403:Cathepsins; D020059:Cathepsin E