title: [Pathophysiology of benign prostatic hyperplasia].
abstract: Benign prostatic hyperplasia (BPH) is primarily a anatomical diagnosis. The prepubertal weight of the gland is about 1.6 g and at the end of the third decade around 20 g. With histological evidence for BPH there is an increase of weight and volume with aging. The human prostate is divided into zones which form, however, a fairly regular gland. The prostate is organized similar to a grape, these parts are surrounded with the epithelial cells which express different compounds and proteins and finally disappear by apoptosis. The stromal compartment is kind of a skeleton, both compartments (epithelial and stromal part) present manifold interactions based on androgens, androgen receptors and growth factors.
authors.affiliation: Urologischen Abteilung, Landeskrankenanstalten Salzburg.
authors.forename: J
authors.initials: J
authors.lastname: Frick
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology; D011467:Prostate / Q000473:pathology / Q000503:physiopathology; D011470:Prostatic Hyperplasia / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000502:physiology; D012741:Sexual Maturation / Q000502:physiology
chemical_list: D000728:Androgens; D006133:Growth Substances; D011944:Receptors, Androgen
vernacular_title: Pathophysiologie der benignen Prostatahyperplasie.