Paradoxical bronchospasm and cutaneous rash after metered-dose inhaled bronchodilators.
The authors describe a case of paradoxical bronchospasm with laryngospasm and cutaneous rash occurring in an asthmatic woman after the use, via metered-dose inhaler, of different bronchodilators containing soy-derived excipients. It is noteworthy that the patient was not affected by soy allergy. After a short review of the relevant literature, the authors consider the possible aetiopathogenetic factors and outline the importance of this rare adverse reaction in the care of asthmatic patients.
Facchini
G
G
Divisione di Pneumologia, Ospedale Regionale, Ancona, Italy.
Antonicelli
L
L
Cinti
B
B
Bonifazi
F
F
Massei
V
V
D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage; D001986:Bronchial Spasm / Q000139:chemically induced*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005079:Excipients / Q000009:adverse effects*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage; D007826:Laryngismus / Q000139:chemically induced; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D013025:Glycine max / Q000009:adverse effects
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D005079:Excipients; D005280:Fenoterol; D009241:Ipratropium; D001507:Beclomethasone; D000420:Albuterol