Five-year outcome after epilepsy surgery in nonmonitored and monitored surgical candidates.
OBJECTIVE
We wished to compare outcome 5 years after temporal lobectomy in 28 patients selected for surgery on the basis of interictal EEG patterns with that in 46 patients who underwent EEG-video monitoring studies as part of their preoperative evaluation during the same era.


METHODS
The 28 nonmonitored patients had interictal EEG patterns that demonstrated a consistent, unilateral, anterior-midtemporal epileptiform focus, without discordant findings from other studies. Outcomes were assessed for years 4 and 5 after operation.


RESULTS
Twenty-six of 28 (92.9%) nonmonitored patients were seizure-free or had at least 75% reduction in seizures. Twenty-nine of 46 (63.0%) monitored patients were seizure-free or had at least 75% reduction in seizures. Preoperative interictal EEGs of 29 of these patients showed independently localized bitemporal, extratemporal, midposterior temporal, or diffuse epileptiform patterns. The remaining 17 monitored patients had preoperative strictly unilateral anterior-midtemporal interictal discharges, and their outcome was comparable to the nonmonitored group, with 15 (88.8%) seizure-free or with at least 75% reduction in seizures.


CONCLUSIONS
A proportion of candidates for epilepsy surgery can be selected without ictal recordings provided that interictal EEGs demonstrate consistent unilateral anterior-midtemporal epileptiform discharges and that other data are not discordant.
Holmes
M D
MD
Department of Medicine (Neurology), University of Washington, School of Medicine, Seattle, USA.
Dodrill
C B
CB
Ojemann
L M
LM
Ojemann
G A
GA
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000473:pathology; D002828:Choristoma / Q000473:pathology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D005911:Gliosis / Q000473:pathology; D006222:Hamartoma / Q000473:pathology; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D011300:Preoperative Care; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome