Human germinal mutagenic effects in relation to intentional and accidental exposure to toxic agents.
This paper presents examples of epidemiological evaluation of exposure- and cluster-type mutations in human populations. The self-poisoning model did not show that offspring born from mothers after a semi-lethal self-poisoning had higher rates of prenatal selection (fetal death) or abnormalities due to germinal mutations; however, an intrauterine growth retardation was found. The surveillance function of the Hungarian Congenital Abnormality Registry has detected many cluster-type situations, one example of which is an extreme increase of Down's syndrome in a small Hungarian village in 1989 to 1990. Environmental investigations have pointed to the excessive use of trichlorfon at local fish farms as the cause.
Czeizel
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Department of Human Genetics and Teratology, National Institute of Hygiene--WHO Collaborating Centre from the Community Control of Hereditary Diseases, Budapest, Hungary. h7254cze@ella.hu
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D016000:Cluster Analysis; D004314:Down Syndrome / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005313:Fetal Death; D005506:Food Contamination; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D011041:Poisoning / Q000150:complications; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012042:Registries; D013406:Suicide, Attempted; D014236:Trichlorfon / Q000506:poisoning*
D014236:Trichlorfon