Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease.
Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed.
Almasy
L
L
Department of Genetics, Yale University, New Haven, Connecticut, USA.
Tierney
C
C
Risch
N
N
D000483:Alleles; D002874:Chromosome Mapping; D003198:Computer Simulation; D005260:Female; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008957:Models, Genetic; D015995:Prevalence; D018570:Risk Assessment
D005819:Genetic Markers