Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats.
This study investigated the effects of low-dose eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) on the incidence, tumor growth and cell kinetics of a 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats fed either a high-fat (20% corn oil) or low-fat (0.5% corn oil) diet. Low-dose EPA and DHA completely blocked the stimulatory effect of fat on tumorigenesis, as demonstrated by a decreased number of tumors per group and per tumor-bearing rat. While EPA and DHA inhibited cell kinetics as evidenced by a decreased bromodeoxyuridine-labeling index, their inhibitory effects on tumor size and tumor doubling time were not significant. These data suggest that low-dose EPA and DHA inhibit tumorigenesis rather than tumor growth in the high-fat group.
Minami
M
M
Department of Surgery (II), Kanazawa University Hospital, School of Medicine, Kanazawa University, Japan.
Noguchi
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002273:Carcinogens; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D004041:Dietary Fats; D004281:Docosahexaenoic Acids; D015127:9,10-Dimethyl-1,2-benzanthracene; D015118:Eicosapentaenoic Acid; D001973:Bromodeoxyuridine