Distribution of drugs following controlled delivery to the brain interstitium.
Intracranial controlled release polymers have been used for drug delivery to the brain, bypassing the blood brain barrier (BBB). By understanding the rates and patterns of transport in the local tissues, it is possible to design delivery systems that provide the optimal spatial and temporal pattern of chemotherapy within the intracranial space. This paper reviews the kinetics of drug release from polymeric controlled release implants, and describes the fate of drug molecules following release into the brain interstitium. Potential improvements in drug delivery based on the understanding of the mechanisms of drug release, transport and elimination are discussed.
Mak
M
M
Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Fung
L
L
Strasser
J F
JF
Saltzman
W M
WM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D004343:Drug Implants; D006801:Humans
D000970:Antineoplastic Agents; D004343:Drug Implants