Hypereosinophilic syndrome with generalized myasthenia gravis.
A patient with hypereosinophilic syndrome simultaneously had generalized myasthenia gravis. Ultrastructural and functional studies demonstrated an increase of the activated hypodense eosinophils. The eosinophilic cationic protein level in plasma and whole blood paralleled the severity of congestive heart failure. A high level of interleukin-5 was detected in both serum and in conditioned medium of T cells by interleukin-2 stimulation before therapy. The findings indicate that both diseases may be associated with a common T-cell abnormality.
Ishida
Y
Y
Department of Pediatrics, Ehime University School of Medicine, Tokyo, Japan.
Hayashi
M
M
Higaki
A
A
Matsumoto
K
K
Iikura
Y
Y
Ishikawa
J
J
Kida
K
K
D001798:Blood Proteins / Q000032:analysis; D002648:Child; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000648:ultrastructure; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D018836:Inflammation Mediators / Q000032:analysis; D008222:Lymphokines / Q000097:blood; D009157:Myasthenia Gravis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012260:Ribonucleases; D013601:T-Lymphocytes / Q000276:immunology
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D005938:Glucocorticoids; D018836:Inflammation Mediators; D008222:Lymphokines; D011239:Prednisolone; D012260:Ribonucleases