Angiogenesis as a new target for cancer treatment.
Neovascularization is often required for rapid growth of solid tumors and also limits vascular metastasis of tumor cells. Neovascularization-targeting agents are a recent innovation that may be a novel means of anticancer therapy. These antiangiogenic drugs have been developed by targeting cell proliferation of vascular endothelial cells, basement-membrane-degrading enzymes, angiogenic factors/receptors, extracellular matrix, angiogenesis signaling, and cell-cell/cell-matrix interactions. In this report, we describe how tumor angiogenesis occurs and how antiangiogenic agents are developed.
Ono
M
M
Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan.
Izumi
H
H
Yoshida
S
S
Goto
D
D
Jimi
S
S
Kawahara
N
N
Shono
T
T
Ushiro
S
S
Ryuto
M
M
Kohno
K
K
Sato
Y
Y
Kuwano
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000517:prevention & control*
D000970:Antineoplastic Agents