title: A controlled study of the efficacy and safety of mianserin and amitriptyline in depressive inpatients.
abstract: As with other second-generation antidepressants, the antidepressive efficacy of mianserin was investigated in double-blind control group studies, mostly under outpatient conditions. This study tested the antidepressive efficacy and safety of mianserin as compared to amitriptyline in a sample of 51 depressed inpatients suffering from major depression. No statistically significant difference was found with regard to the main efficacy outcome criterion, the HAMD. The tolerability results demonstrated a superiority of mianserin with respect to vegetative symptoms and especially with respect to dryness of the mouth.
authors.affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Möller
authors.forename: S
authors.initials: S
authors.lastname: Kasper
authors.forename: H
authors.initials: H
authors.lastname: Müller
authors.forename: W
authors.initials: W
authors.lastname: Kissling
authors.forename: J
authors.initials: J
authors.lastname: Fuger
authors.forename: S
authors.initials: S
authors.lastname: Ruhrmann
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006760:Hospitalization; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010352:Patient Dropouts; D011569:Psychiatric Status Rating Scales
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D008803:Mianserin