[Atrial natriuretic factor (ANF) in massive pulmonary embolism: the effects of heparin treatment].
We have determined, in a group of patients suffering from massive pulmonary embolism, the ANF basic levels and the changes noticeable in anticoagulant treatment. The heparin therapy, in six patients studied, has produced a considerable clinic and functional better conditions as testified by the gradual improving from hypoxemia. The PaO2, in fact, increases from a basic value of 68.7 +/- 17.65 mmHg to 74.68 +/- 7.16 mmHg on the 7th day (p: n.s.) and to 83.66 +/- 12.46 mmHg on the 14th day (p < 0.05 on the basic value) of treatment. At the same time it has been possible to note a decreasing of plasmatic ANF mean concentrations with decrease from a basic value of 250 pg/ml to 190 pg/ml (p: n.s.) after 7 days to 185 pg/ml (p: n.s.) after 14 days of therapy. However the presents of the high values after 14 days, could be considered as evidence of a persisting change of pulmonary arterious circulation. On the basis of such notes we have tied to compare the amount of ANF, in basic conditions, with the degree of scintigraphic alterations. Of the three patients whose PRA had been previously valued (n. 4, 5, 6), n. 4 and n. 5 showed, in basic condition, a suppression of PRA and only n. 5, at the end of treatment, reached a normal range of PRA. In those three patients there hasn't been relevant changes of plasmatic aldosterone concentration during the study.
Bartolucci
L
L
Istituto di Patologia Speciale Medica (R), Università degli Studi di Perugia.
Fioretti
M
M
Rossi
G
G
Commissari
R
R
Valori
C
C
D000208:Acute Disease; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000187:drug effects; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000097:blood* / Q000188:drug therapy*; D013997:Time Factors
D000925:Anticoagulants; D009320:Atrial Natriuretic Factor; D006493:Heparin
Il fattore natriuretico atriale (ANF) nell'embolia polmonare massiva: effetti del trattamento eparinico.