title: Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.
abstract: Members of the transforming growth factor-beta (TGF-beta) superfamily have been found to signal by inducing the formation of hetero-oligomeric complexes of different type I and type II serine/threonine kinase receptors. Recent data indicate that binding of TGF-beta to its constitutively active type II receptor recruits the type I receptor into the complex; the type I receptor is thereafter phosphorylated and activated, processes which are necessary and sufficient for most TGF-beta mediated responses. Recent genetic analyses of Drosophila also indicate a strict requirement for both type I and type II receptors in decapentaplegic signaling in vivo.
authors.affiliation: Ludwig Institute for Cancer Research, Box 595, Biomedical Center, Uppsala, S-751 24, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: ten Dijke
authors.forename: K
authors.initials: K
authors.lastname: Miyazono
authors.forename: C H
authors.initials: CH
authors.lastname: Heldin
mesh_terms: D030201:Activin Receptors, Type I; D000818:Animals; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II