title: Prevalence of factor V gene mutation amongst myocardial infarction patients and healthy controls is higher in Sweden than in other countries.
abstract: OBJECTIVE
  Haemostatic imbalance may be an aetiological factor in the development of acute coronary syndromes. Inherited resistance to activated protein C (APC) is a common disorder associated with hypercoagulability and lifelong risk of venous thrombosis. APC resistance is due to a single mutation in the gene coding for coagulation factor V (FV:Q506). To test the importance of the FV:Q506 mutation in premature myocardial infarction (MI), its prevalence was investigated in Swedish patients with MI before the age of 50 years.
  
  
  METHODS
  In a retrospective case-control study, the FV:Q506 mutation was investigated in 101 survivors of MI (79 men, 22 women) and in 101 healthy sex- and age-matched controls.
  
  
  METHODS
  The prevalence of FV:Q506 mutation.
  
  
  RESULTS
  The FV:Q506 mutation was found in 18% of patients versus 11% of controls (P = 0.16). The mutation was significantly more frequent amongst male patients than amongst controls (23 vs. 10%; P = 0.03), the calculated odds ratio being 2.6 (95% CI, 1.1-6.4).
  
  
  CONCLUSIONS
  The high prevalence of the FV:Q506 mutation found amongst Swedish MI patients, especially amongst men, is noteworthy, and calls for further studies on the outcome of MI in APC-resistant patients. The prevalence of the FV:Q506 mutation in controls is higher than figures reported from other countries, suggesting that at least 10% of the Swedish population are carriers of a congenital prothrombotic disorder.
authors.affiliation: Department of Cardiology, University of Lund, University Hospital, Malmö, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Holm
authors.forename: B
authors.initials: B
authors.lastname: Zöller
authors.forename: E
authors.initials: E
authors.lastname: Berntorp
authors.forename: L
authors.initials: L
authors.lastname: Erhardt
authors.forename: B
authors.initials: B
authors.lastname: Dahlbäck
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011486:Protein C / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology / Q000235:genetics
chemical_list: D011486:Protein C; D005165:Factor V