Variability of genotype-specific penetrance probabilities in the calculation of risk support intervals.
Previously, a maximum likelihood method was described to construct a support interval for the risk. This method is extended to incorporate genotype specific penetrance probabilities in the calculation of a risk support interval. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred.
Leal
S M
SM
Department of Otolaryngology, University of Tübingen, Germany.
Ott
J
J
D017668:Age of Onset; D001943:Breast Neoplasms / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics; D010641:Phenotype; D011336:Probability; D015203:Reproducibility of Results; D018570:Risk Assessment