title: Metoclopramide in trauma CT scanning: preventing emesis of oral radiographic contrast.
abstract: Vomiting of gastric contents is common among multisystem trauma patients and may cause significant morbidity. A study was conducted to examine whether metoclopramide (Reglan), an antiemetic and promotility agent, could decrease vomiting after administration of oral radiographic contrast in stable multisystem trauma patients undergoing computed tomography (CT) of the abdomen ("trauma CT patients"). The charts of 193 patients listed in the Duke Trauma Registry who underwent abdominal CT scanning from January, 1992 until February, 1993 were reviewed. The emergency department record was reviewed for documentation of vomiting, use of intravenous metoclopramide, and other potential confounders of vomiting such as age, pharmacologic paralysis, and head injury as measured by the Glasgow Coma Scale (GCS). Patients who received intravenous metoclopramide were six times less likely to vomit after administration of oral radiographic contrast than those who did not receive the drug. This effect increased to a twelvefold protective effect after correcting for age, pharmacologic paralysis, and GCS. These preliminary findings strongly suggest that routine use of metoclopramide may prevent vomiting of gastric contents after administration of oral radiographic contrast in trauma CT patients. A future prospective study is recommended to confirm these results.
authors.affiliation: Department of Emergency Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: B
authors.initials: B
authors.lastname: Page
authors.forename: J
authors.initials: J
authors.lastname: Dallara
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000932:Antiemetics / Q000627:therapeutic use*; D003287:Contrast Media / Q000009:adverse effects*; D015600:Glasgow Coma Scale; D006801:Humans; D007275:Injections, Intravenous; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014193:Trauma Centers; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D003287:Contrast Media; D008787:Metoclopramide