Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis.
Members of the ICE/CED-3 protease family appear to play an essential role in programmed cell death process. In this paper the chromosomal localization of the human genes CPP32, Mch2, Mch3 and Ich-1 is reported, obtained by Radiation Hybrid Mapping. CPP32 was assigned to chromosome 4q33-q35.1, Mch2 to chromosome 4q25-q26, Mch3 to chromosome 10q25.1-q25.2 and Ich-1 to chromosome 7q35. Ich-1 was found to map very close to the marker WI-9353. The possible overlapping of the two independent locus assignments is considered. The genomic distribution of these genes is discussed, with particular reference to the co-location with some human genetic diseases all characterized by autosomal dominant inheritance and by similar malformative features.
Tiso
N
N
Biology Department, University of Padova, Italy.
Pallavicini
A
A
Muraro
T
T
Zimbello
R
R
Apolloni
E
E
Valle
G
G
Lanfranchi
G
G
Danieli
G A
GA
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001483:Base Sequence; D053143:Caspase 2; D053148:Caspase 3; D053178:Caspase 6; D020169:Caspases; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D000013:Congenital Abnormalities / Q000235:genetics; D006224:Cricetinae; D003546:Cysteine Endopeptidases / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics
D017931:DNA Primers; D011506:Proteins; C505407:CASP3 protein, human; C505514:CASP6 protein, human; D053143:Caspase 2; D053148:Caspase 3; D053178:Caspase 6; D020169:Caspases; D003546:Cysteine Endopeptidases