title: Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.
abstract: The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.
authors.affiliation: Max von Pettenkofer-Institut, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Bauernfeind
authors.forename: I
authors.initials: I
authors.lastname: Stemplinger
authors.forename: R
authors.initials: R
authors.lastname: Jungwirth
authors.forename: H
authors.initials: H
authors.lastname: Giamarellou
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D018550:Cephalosporin Resistance / Q000235:genetics*; D002513:Cephamycins / Q000494:pharmacology*; D003001:Cloning, Molecular; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000302:isolation & purification; D005798:Genes, Bacterial; D007525:Isoelectric Focusing; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000737:chemistry*; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D002513:Cephamycins; D004269:DNA, Bacterial; C103022:beta-lactamase CMY-2; D001618:beta-Lactamases