title: Immunogenicity, efficacy and safety of an oral rabies vaccine (SAG-2) in dogs.
abstract: A study of immunogenicity and efficacy of Street Alabama Gif (SAG-2) attenuated rabies virus vaccine in laboratory beagles was conducted. Four groups of ten dogs each received either 1.0 ml of SAG-2 orally on the tongue or 1.5 ml in baits. On day 180 postvaccination, all dogs were challenged with a street rabies virus. The antibody response in groups that received the vaccine directly on the tongue was higher than in those vaccinated with baits, but the difference between groups was not statistically significant. All vaccinated dogs survived, whereas 80% of controls died of rabies. Our findings demonstrate that the SAG-2 is a safe and effective vaccine for oral immunization of canines.
authors.affiliation: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: M
authors.initials: M
authors.lastname: Fekadu
authors.forename: S L
authors.initials: SL
authors.lastname: Nesby
authors.forename: J H
authors.initials: JH
authors.lastname: Shaddock
authors.forename: C L
authors.initials: CL
authors.lastname: Schumacher
authors.forename: S B
authors.initials: SB
authors.lastname: Linhart
authors.forename: D W
authors.initials: DW
authors.lastname: Sanderlin
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D004285:Dogs; D007928:Lethal Dose 50; D011818:Rabies / Q000517:prevention & control* / Q000662:veterinary*; D011819:Rabies Vaccines / Q000009:adverse effects / Q000235:genetics / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology / Q000302:isolation & purification; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology*
chemical_list: D011819:Rabies Vaccines; D014614:Vaccines, Synthetic