Quantitative assay of photoinduced antibiotic activities of naturally-occurring 2,2':5',2"-terthiophenes.
Nine naturally-occurring 2,2':5',2"-terthiophenes were quantitatively evaluated for their in vitro photoinduced growth inhibitory activity against three bacterial strains. All the compounds proved active towards Staphylococcus aureus. As regards Escherichia coli, the unsubstituted 2,2':5'2"-terthiophene (MIC = 0.62 microgram/ml at 4j/cm2 fluence), was found to be the only compound active. None of the compounds tested displayed activity on Pseudomonas aeruginosa at the highest concentration tested.
Ciofalo
M
M
Petruso
S
S
Schillaci
D
D
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects; D008027:Light; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects
D000900:Anti-Bacterial Agents; D013876:Thiophenes; C019101:alpha-terthienyl