Comparison of the effects of an aqueous extract of Physalis alkekengi fruits and/or various doses of 17-beta-estradiol on rat estrous cycle and uterine glucose 6-phosphate dehydrogenase activity.
Intraperitoneal injections of an aqueous extract of winter cherry fruits (Physalis alkekengi) to adult normal cycling female rats produced 100% diestrus and diminished uterine glucose 6-P dehydrogenase activity (an estrogen-induced protein) by 52%. Daily doses of 1.88, 3.75 and 7.5 micrograms 17-beta-estradiol administered intraperitoneally to adult female rats for a period of 6-8 days prolonged proestrus or estrus and increased uterine glucose 6-P dehydrogenase activity by 11.5%, 26.9% and 82.1%, respectively. Combined intraperitoneal injections of a given dose of the aqueous extract together with the above doses of 17-beta-estradiol for 8 consecutive days shortened the time spent in diestrus proportional to the dose employed and proportionately reduced the uterine glucose 6-P dehydrogenase inhibitory power of the aqueous extract (1.88 micrograms estradiol, 33.9% inhibition; 3.75 micrograms estradiol, 27% inhibition; and 7.5 micrograms estradiol, 6.0% activation). The data obtained clearly demonstrate the presence of an estrogen antagonist in the aqueous extract of Physalis alkekengi fruits.
Vessal
M
M
Department of Biochemistry, Shiraz University of Medical Sciences, Iran.
Yazdanian
M
M
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D007202:Indicators and Reagents; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D004965:Estrogen Antagonists; D007202:Indicators and Reagents; D010936:Plant Extracts; D004958:Estradiol; D005954:Glucosephosphate Dehydrogenase