[Effect of Yersinia pseudotuberculosis pVM82 on the activity of components of complement and phagocytosis by human blood neutrophils].
Three isogenic Y. pseudotuberculosis strains were studied. One of them contained pVM82 plasmid which was found in foci of pseudotuberculosis outbreaks and increased Yersinia resistance to blood serum. Cells with pVM82 plasmid did not inhibit the activation of complement components C1, C2, C3, C4, and C5 in human serum and increased the consumption of these complement components in comparison with control strains. Y. pseudotuberculosis cells with pVM82 were better resistant to human neutrophil phagocytosis than bacterial cells without this plasmid. For the strain with pVM82 plasmid, a lower level of phagocytosis within the first 30 min of Y. pseudotuberculosis incubation with neutrophils and a reduced percentage of killed bacteria among all those phagocytosed over the entire period of incubation of bacteria with neutrophils were observed.
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D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D010957:Plasmids; D015011:Yersinia pseudotuberculosis / Q000235:genetics*
D003165:Complement System Proteins
Vliianie plazmidy pVM86 Yersinia pseudotuberculosis na aktivnost' komponentov komplementa i fagotsitoz neĭtrofilami krovi cheloveka.