title: Severe varicella pneumonia in adults in Stockholm County 1980-1989.
abstract: Varicella pneumonia in adults is considered to be a serious complication, with mortality rates of 9-50%, but the true incidence and clinical course is not known. We therefore studied all adult patients in Stockholm County hospitalized during the period 1980-1989 with varicella. 36/305 (12%) varicella patients admitted to hospital were diagnosed as having pneumonia, corresponding to a mean incidence of 0.32/100,000 inhabitants per year. In most patients the pneumonia had a mild to moderate clinical course and no deaths occurred (mortality rate 0%, CI95 [0, 9.7]). However, 13 patients had a severe tachypnoea (> or = 30 breaths/min) and 4 of these required intensive-care treatment. Ten patients were treated with acyclovir, in most cases combined with corticosteroids. We conclude that the incidence of severe varicella pneumonia is low in the adult population, and that the mortality rate of this complication is probably lower than previously described.
authors.affiliation: Department of Pediatrics, St. Görans Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Ortqvist
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008297:Male; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents; D000212:Acyclovir