[The efficacy and safety of glucosamine sulfate in the treatment of gonarthritis].
This study was performed to evaluate the therapeutic efficacy and tolerability of glucosamine sulfate in patients with gonarthritis. During the 12-month study period, the signs and symptoms of the disease were evaluated, as well as the dosage of the urinary pyridinoline. In this trial, we demonstrated that glucosamine sulfate has a chondroprotective activity, which was significant after the first 3 months of therapy. Moreover, this study showed that the side effects due to glucosamine sulfate were mild to moderate and did not require discontinuation of the drug.
Giordano
N
N
Istituto di Patologia Speciale Medica, Università degli Studi di Siena.
Nardi
P
P
Senesi
M
M
Palumbo
F
F
Battisti
E
E
Gonnelli
S
S
Franci
B
B
Campagna
M S
MS
Gennari
C
C
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000627:therapeutic use*; D000606:Amino Sugars / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D005944:Glucosamine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D016896:Treatment Outcome
D000596:Amino Acids; D000606:Amino Sugars; C015484:pyridinoline; D005944:Glucosamine
Efficacia e tollerabilità della glucosamina solfato nel trattamento della gonartrosi.