Drug-associated pancreatitis: facts and fiction.
In the past, numerous reports on drugs probably causing acute pancreatitis have been published. However, most of these case reports were anecdotal with a lack of obvious evidence and did not present a comprehensive summary. Although drug-associated pancreatitis is rare, it is gaining increasing importance with the introduction of several potent new agents, i.e., anti-acquired immunodeficiency syndrome drugs. The following comprehensive review scrutinizes the evidence present in the world literature on drugs associated with acute or chronic pancreatitis and, based on this, categorizes in a definite, probable, or possible causality. In addition, explanations for the pathophysiological mechanisms are discussed.
Rünzi
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Department of Medicine, University of Essen, Germany.
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D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D000998:Antiviral Agents / Q000009:adverse effects; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D004232:Diuretics / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D010195:Pancreatitis / Q000139:chemically induced*; D012459:Salicylates / Q000009:adverse effects; D013256:Steroids / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004232:Diuretics; D007166:Immunosuppressive Agents; D012459:Salicylates; D013256:Steroids; D002118:Calcium