title: Introns and protein revolution--an analysis of the exon/intron organisation of actin genes.
abstract: A catalogue of intron positions obtained from a large number of actin genes has been compiled with a view to understanding the possible origin of intervening sequences. Actins are ubiquitous proteins conserved in evolution and an analysis of their gene structures from various organisms has revealed that there may be at least 25 intron positions distributed at different positions in the coding regions. A comparison of intron positions from a wide range of organisms from that of yeast to human actins shows that introns could be more ancestral in origin. The conservation in the observed intron patterns within the different tissue types hints at a possible functional significance of introns in present day actin genes.
authors.affiliation: Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, India.
authors.forename: S
authors.initials: S
authors.lastname: Bagavathi
authors.forename: R
authors.initials: R
authors.lastname: Malathi
mesh_terms: D000199:Actins / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D005091:Exons; D006801:Humans; D007438:Introns; D010802:Phylogeny
chemical_list: D000199:Actins