title: Families of ion channels with two hydrophobic segments.
abstract: The family of epithelial sodium channels and nematode degenerins has expanded recently to include a member found only in brain, and another that functions in molluscs as a ligand-gated channel. A new gene family of mammalian ATP-gated channels has been discovered; one of its seven members plays a role in the lysis of macrophages. The mechanosensitive channel of bacteria has emerged as the simplest form of a channel protein subunit with two hydrophobic domains.
authors.affiliation: Glaxo Institute for Molecular Biology, 14 chemin des Aulx, Plan-les-Quates, 1228 Geneva, Switzerland. RAN8881@ggr.co.uk
authors.forename: R A
authors.initials: RA
authors.lastname: North
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry* / Q000145:classification*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
chemical_list: D007473:Ion Channels