Reperfused ischemia of the rat intestine: detection by MR imaging with polylysine-Gd-DTPA enhancement.
To detect reperfused ischemia of the rat intestine, T2-weighted spin-echo images were acquired, followed by T1-weighted images before and after administration of polylysine-Gd-DTPA or Gd-DTPA. Before administration of the contrast agent, the reperfused intestine was hyperintense on T2-weighted images, and to a lesser extent on T1-weighted images. After administration of polylysine-Gd-DTPA, the reperfused intestine enhanced more than the normal one, giving a significantly better contrast-to-noise (CNR) ratio than on unenhanced images. Gd-DTPA induced the same enhancement of the reperfused and the normal intestine and the CNR was lower than on unenhanced T2-weighted images. Reperfused intestinal ischemia could thus be better detected on polylysine-Gd-DTPA-enhanced MR images than on unenhanced images or on Gd-DTPA-enhanced images.
Mottet
I
I
Department of Radiology and Medical Imaging, Cliniques Universitaires St-Luc, Brussels, Belgium.
Van Beers
B E
BE
Delos
M
M
Goudemant
J F
JF
Jamart
J
J
Demeure
R
R
Pringot
J
J
D000818:Animals; D003287:Contrast Media; D019786:Gadolinium DTPA; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000473:pathology; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology; D007422:Intestines / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011107:Polylysine; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000175:diagnosis* / Q000473:pathology
D003287:Contrast Media; D009942:Organometallic Compounds; D011107:Polylysine; D004369:Pentetic Acid; D019786:Gadolinium DTPA