Successful transplantation of cadaver hearts harvested one hour after hypoxic cardiac arrest.
BACKGROUND
A shortage of donor organs in clinical transplantation prompted us to study whether resuscitated "dead" hearts could be used for successful orthotopic heart transplantation.


METHODS
Donor hearts were resuscitated with cardiopulmonary bypass after 3 minutes (the control group; n = 8) or 60 minutes (the experimental group; n = 6) of hypoxic cardiac arrest after induction of brain death.


RESULTS
All the animals of each group were successfully weaned from cardiopulmonary bypass with 5 micrograms/kg/min of dopamine 1 hour after transplantation, and cardiac function with or without dopamine was better preserved in the experimental group than the control group (with maximum slope of pressure-volume relationship with dopamine: 198.0% +/- 36.8% versus 121.2% +/- 47.2%; maximum slope of pressure-volume relationship without dopamine: 130.6% +/- 41.5% versus 70.8% +/- 21.5% [mean +/- standard deviation] as percentage of values after brain death, respectively; p < 0.01 by unpaired t test).


CONCLUSIONS
These results indicate that cadaver hearts 60 minutes after anoxic arrest can be successfully reanimated and orthotopically engrafted with various methods and drugs.
Takagaki
M
M
Second Department of Surgery, Okayama University Medical School, Japan.
Hisamochi
K
K
Morimoto
T
T
Bando
K
K
Sano
S
S
Shimizu
N
N
D000818:Animals; D016279:Atrial Function, Left; D001794:Blood Pressure; D001926:Brain Death; D002102:Cadaver; D002302:Cardiac Output; D002306:Cardiac Volume; D002315:Cardiopulmonary Bypass; D004285:Dogs; D004298:Dopamine / Q000627:therapeutic use; D006323:Heart Arrest; D016027:Heart Transplantation / Q000502:physiology; D000860:Hypoxia; D009926:Organ Preservation; D012151:Resuscitation; D013997:Time Factors; D009927:Tissue and Organ Procurement
D004298:Dopamine