title: Mapping of hereditary neuralgic amyotrophy (familial brachial plexus neuropathy) to distal chromosome 17q.
abstract: Hereditary neuralgic amyotrophy with predilection for the brachial plexus (HNA) is an autosomal dominant disorder associated with recurrent, episodic, painful brachial neuropathies. Mildly dysmorphic facial features, including hypotelorism, long nasal bridge, and upslanting palpebral fissures, are present in affected persons in some pedigrees with HNA. To determine the chromosomal location of the HNA gene, we carried out genetic linkage studies with polymerase chain reaction-based DNA markers in two large pedigrees. Linkage to markers from the distal long arm of chromosome 17 was established.
authors.affiliation: Division of Neurology, Children's Hospital of Philadelphia, PA 19104, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Pellegrino
authors.forename: T R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: M J
authors.initials: MJ
authors.lastname: Brown
authors.forename: T D
authors.initials: TD
authors.lastname: Bird
authors.forename: P F
authors.initials: PF
authors.lastname: Chance
mesh_terms: D000328:Adult; D020968:Brachial Plexus Neuritis / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers