title: Early postoperative stress: video-assisted wedge resection/lobectomy vs conventional axillary thoracotomy.
abstract: Postoperative pain is a major cause of ineffective breathing after lung surgery, predisposing patients to hypoxemia. Because potent analgesics like opioids depress ventilation and other analgesic techniques are time-consuming, efficient postoperative pain therapy is difficult. Therefore, a less painful surgical approach could be beneficial. Forty-seven patients with diagnosis of a pulmonary nodule were prospectively studied. Patients were assigned to a video-assisted thoracic surgery (VATS) group (n=22) or a group undergoing axillary thoracotomy (n=25). Visual analogue scale (VAS) scores, plasma glucose levels, plasma epinephrine and plasma norepinephrine levels, as well as arterial oxygen (PaO2) and carbon dioxide (PaCO2) tension were determined the day before surgery, and 3, 15, 24, 48, and 72 h after surgery. Postoperative piritramide (a synthetic morphine compound) demand was recorded. VAS values were significantly lower (p<0.05) during the whole observation period in the VATS group. Significantly higher epinephrine levels were observed 3 and 15 h after surgery (267.4 +/- 28 vs 111.8 +/- 13 ng/L; p<0.01; and 176.6 +/- 46.5 vs 96 +/- 14.5 ng/L; p<0.05) in the thoracotomy group, whereas there was no significant difference in norepinephrine (correction of norephinephrine) levels. Piritramide demand was significantly (p<0.05) reduced in the VATS group throughout the whole observation period. There was no difference in PaCO2 values but PaO2 Values were higher in the VATS group over 72 h, with maximum differences occurring at 15 h after operation: 60.9 +/- 1.9 vs 49.2 +/- 2.4 mm Hg (p<0.01). In conclusion, the videoendoscopic approach is associated with less postoperative pain and better oxygenation than traditional surgical approaches.
authors.affiliation: Department of Cardiothoracic Anesthesia and Intensive Care, General Hospital, University of Vienna, Austria.
authors.forename: E M
authors.initials: EM
authors.lastname: Tschernko
authors.forename: S
authors.initials: S
authors.lastname: Hofer
authors.forename: C
authors.initials: C
authors.lastname: Bieglmayer
authors.forename: W
authors.initials: W
authors.lastname: Wisser
authors.forename: W
authors.initials: W
authors.lastname: Haider
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D004724:Endoscopy; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D010100:Oxygen / Q000097:blood; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D010892:Pirinitramide / Q000627:therapeutic use; D011013:Pneumonectomy / Q000379:methods*; D011183:Postoperative Complications; D011446:Prospective Studies; D003074:Solitary Pulmonary Nodule / Q000601:surgery; D013312:Stress, Physiological / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D013908:Thoracotomy / Q000379:methods*; D014741:Video Recording
chemical_list: D000701:Analgesics, Opioid; D001786:Blood Glucose; D002245:Carbon Dioxide; D010892:Pirinitramide; D010100:Oxygen; D009638:Norepinephrine; D004837:Epinephrine