title: Genetic resistance of Creole goats to cowdriosis in Guadeloupe. Status in 1995.
abstract: A genetic predisposition to resistance (R)/susceptibility (S) has been demonstrated for cowdriosis in certain goal lines. In order to identify genetic markers of R/S and to follow their transmission to the offspring, 4 groups of sires and dams were crossbred in 1991, 1992, and 1993: Rr, RS, SR, and SS. The offspring were challenged at the age of six months with subsequent challenge of the S parent. From 28 presumed S dams, 7 turned out R and from 2 presumed S sires, 1 was R and the other undefinable. The resistance rate was 76% for 21 RR kids and 45% for 20 RS kids. The R character seems to be better transmitted by dams than the S one. No difference was observed between R and S goats in terms of incubation period and body temperature level after challenge. There was no statistical effect found of sex, litter size, or birth mass on the R/S character; only a slight effect on daily mass gain was observed. Sperm has been collected from 4 S sires (died after challenge) and 5 R sires, and stored in liquid nitrogen in order to conceive additional SR and SS progeny. Several caprine leucocyte antigens seem to be genetic markers of R (Be 1, CLY) and of S (Be 9, Be 22, Be 23). Further powerful tools like microsatellites and probes defining other interesting loci possibly involved in disease pathogenesis are now at hand and will be included in future experiments.
authors.affiliation: CIRAD-EMVT, PAP, Guadeloupe, French West Indies.
authors.forename: E
authors.initials: E
authors.lastname: Camus
authors.forename: J C
authors.initials: JC
authors.lastname: Maillard
authors.forename: G
authors.initials: G
authors.lastname: Ruff
authors.forename: L
authors.initials: L
authors.lastname: Pepin
authors.forename: M
authors.initials: M
authors.lastname: Naves
authors.forename: G
authors.initials: G
authors.lastname: Matheron
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D016995:Ehrlichia ruminantium; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015511:Goat Diseases; D006041:Goats / Q000235:genetics* / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics; D007814:Larva; D008297:Male; D011110:Polymorphism, Genetic; D011336:Probability; D011995:Recombination, Genetic; D012288:Rickettsiaceae Infections / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*; D013094:Spermatozoa / Q000382:microbiology; D013987:Ticks
chemical_list: D005819:Genetic Markers