Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment.
Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days. Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.
Coccaro
E F
EF
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia, USA.
Kavoussi
R J
RJ
Trestman
R L
RL
Gabriel
S M
SM
Cooper
T B
TB
Siever
L J
LJ
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000493:pharmacokinetics; D011388:Prolactin / Q000097:blood*; D012016:Reference Values; D015203:Reproducibility of Results; D017366:Serotonin Receptor Agonists / Q000493:pharmacokinetics
D010879:Piperazines; D017366:Serotonin Receptor Agonists; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone