title: Celiac disease with cerebral calcium and silica deposits: x-ray spectroscopic findings, an autopsy study.
abstract: An increased incidence of seizures and cerebral calcifications, usually bilateral and located in the occipital cortex, has been reported in celiac patients. The histology of cerebral lesions is not well defined, and their pathogenesis is only speculative. We report the autopsy results of a patient with celiac disease, seizures, and cerebral calcifications who died following a cerebral hemorrhage caused by Fisher-Evans syndrome. Calcifications were restricted to the cortical gray matter and composed of aggregates of small calcified spicules. Calcium deposition was present as psammoma-like bodies, along small vessels, and within neurons. X-ray spectroscopy of the calcified areas revealed that calcium (43%) and silica (57%) were present in the lesions. High silica content was also found in the cerebral hemorrhagic fluid. Silica toxicity has to be considered in regard to the pathogenesis of the cerebral lesions and of the seizures.
authors.affiliation: Department of Pathology, University of Siena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Toti
authors.forename: P
authors.initials: P
authors.lastname: Balestri
authors.forename: M
authors.initials: M
authors.lastname: Cano
authors.forename: P
authors.initials: P
authors.lastname: Galluzzi
authors.forename: T
authors.initials: T
authors.lastname: Megha
authors.forename: M A
authors.initials: MA
authors.lastname: Farnetani
authors.forename: M L
authors.initials: ML
authors.lastname: Palmeri
authors.forename: M
authors.initials: M
authors.lastname: Vascotto
authors.forename: C
authors.initials: C
authors.lastname: Venturi
authors.forename: A
authors.initials: A
authors.lastname: Fois
mesh_terms: D001344:Autopsy; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D002114:Calcinosis / Q000150:complications; D002118:Calcium / Q000378:metabolism*; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D012640:Seizures / Q000150:complications; D012822:Silicon Dioxide / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D012822:Silicon Dioxide; D002118:Calcium