title: [AIDS-related cryptococcal meningitis at the Bobo-Dioulasso Hospital Center: five case reports].
abstract: The authors report five cases of Cryptococcus neoformans meningitis in HIV-positive patients hospitalized in the Souro Sanou National Hospital Center of Bobo-Dioulasso (Burkina Faso). There were 3 men and 2 women with a mean age of 36 years (range: 29 to 47 years). Presenting symptoms were persistent headache and/or mental confusion and neurosensory defects. Cerebrospinal fluid was clear with less than 20 lymphocytes/mm3. Albumin concentration greater than 0.50 g/l was observed in only one case. India ink smear and culture demonstrated strains of Cryptococcus neoformans sensitive to amphotericin B in all five cases, flucytosin in 3 cases, and ketoconazole in two cases. Four patients died within 15 to 32 days after admission (mean 22.5 days). Delayed diagnosis and inconsistent availability of systemic antifungal drugs are major limiting factors in the management of Cryptococcus neoformans meningitis in Burkina Faso.
authors.affiliation: Service de Médecine Interne, I'Hôpital National Souro Sanou, Bobo-Dioulasso, Burkina Faso.
authors.forename: G A
authors.initials: GA
authors.lastname: Ki-Zerbo
authors.forename: A
authors.initials: A
authors.lastname: Sawadogo
authors.forename: A
authors.initials: A
authors.lastname: Millogo
authors.forename: J B
authors.initials: JB
authors.lastname: Andonaba
authors.forename: A
authors.initials: A
authors.lastname: Yameogo
authors.forename: I
authors.initials: I
authors.lastname: Ouedraogo
authors.forename: M
authors.initials: M
authors.lastname: Tamini
authors.forename: B
authors.initials: B
authors.lastname: Konate
authors.forename: G
authors.initials: G
authors.lastname: Durand
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D002050:Burkina Faso; D017809:Fatal Outcome; D005260:Female; D006786:Hospitals, Urban; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
vernacular_title: La cryptococcose neuro-méningée au cours du SIDA au Centre Hospitalier de Bobo- Dioulasso: à propos de cinq cas.