Lack of functional correlation between gamma-glutamyl transpeptidase and amino acid transport in the lactating mouse mammary gland.
Gamma-glutamyl transpeptidase (EC 2.3.2.2) in lactating mouse mammary gland was inhibited by affinity labelling of the tissue with 6-diazo-5-oxo-L-norleucine. Amino acid (L-alanine, L-methionine) uptake by the affinity labelled mammary gland tissue and the control tissue was measured in vitro. Uptake of amino acids by the affinity-labelled tissue was comparable to that of control tissue. These findings suggest that gamma-glutamyl cycle is not involved in amino acid uptake by the mammary gland.
Kansal
R
R
Animal Biochemistry Division, National Dairy Research Institute, Karnal, India.
Kansal
V K
VK
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D005260:Female; D007774:Lactation / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D051379:Mice; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D000596:Amino Acids; D005723:gamma-Glutamyltransferase