Purified neem (Azadirachta indica) seed extracts (Praneem) abrogate pregnancy in primates.
The use of neem (Azadirachta indica) seed extracts (Praneem) given orally for abrogation of pregnancy in subhuman primates is described. Oral administration of Praneem was initiated after confirmation of pregnancy using Leydig cell bioassay estimating rising levels of chorionic gonadotropin (CG) in the blood from day 25 onwards of the cycle and continued for six days. Termination of pregnancy was observed with the appearance of blood in the vaginal smears and decline in CG and progesterone. Pregnancy continued in the control animals treated with peanut oil at the same dose. The effect was observed in both baboons and bonnet monkeys. The treatment was well tolerated; blood chemistry and liver function tests had normal values. The animals regained their normal cyclicity in the cycles subsequent to Praneem treatment.
Mukherjee
S
S
International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Lohiya
N K
NK
Pal
R
R
Sharma
M G
MG
Talwar
G P
GP
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D006063:Chorionic Gonadotropin / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000502:physiology; D066298:In Vitro Techniques; D008255:Macaca radiata; D008297:Male; D008598:Menstruation / Q000187:drug effects; D010215:Papio; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014592:Uterine Hemorrhage / Q000139:chemically induced; D014621:Vagina / Q000502:physiology
D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D010936:Plant Extracts; C086286:Praneem; D011374:Progesterone; D011803:Quinine