title: Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.
authors.affiliation: Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, South Australia.
authors.forename: J O
authors.initials: JO
authors.lastname: Miners
authors.forename: D J
authors.initials: DJ
authors.lastname: Birkett
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D002747:Chlorpropamide / Q000032:analysis / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000378:metabolism; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology; D015335:Molecular Probes; D015203:Reproducibility of Results; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000378:metabolism*; D013379:Substrate Specificity; D014044:Tolbutamide / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D000096926:Benzenesulfonamides
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; D002747:Chlorpropamide; D003577:Cytochrome P-450 Enzyme System; D007004:Hypoglycemic Agents; D015335:Molecular Probes; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases; D014044:Tolbutamide; C031014:hydroxymethyltolbutamide; D000096926:Benzenesulfonamides