title: Prevalence and correlates of mixed-handedness in schizophrenia.
abstract: Increased rates of nonright-handedness have been reported in schizophrenia, but a clear distinction has not been made between left- and mixed-handedness. Handedness preferences in 96 patients fulfilling DSM-III criteria for schizophrenia and 43 normal comparison subjects were assessed with the Edinburgh Handedness Inventory. A 100% criterion was used to establish left- and right-handedness. Results were analyzed with mantel-Haenszel odds ratios adjusted for age and sex. The schizophrenic group showed a significant increase in the proportion of mixed-handers compared with the normal group. There was no increase in pure left-handedness in the schizophrenic relative to the normal group. Mixed-handedness in the schizophrenic patients was significantly associated with chronicity of illness. Mixed-handed patients were less likely to have a family history of psychotic illness than patients with strong right- or left-handedness. The results indicate a neurodevelopmental rather than a genetic origin for anomalous lateralization in schizophrenia.
authors.affiliation: St. John of God Psychiatric Services, Cluain Mhuire Family Centre, Blackrock, Co. Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Cannon
authors.forename: M
authors.initials: M
authors.lastname: Byrne
authors.forename: B
authors.initials: B
authors.lastname: Cassidy
authors.forename: C
authors.initials: C
authors.lastname: Larkin
authors.forename: R
authors.initials: R
authors.lastname: Horgan
authors.forename: N P
authors.initials: NP
authors.lastname: Sheppard
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics