Detection of quinine and its metabolites in horse urine by gas chromatography-mass spectrometry.
After oral administration of quinine sulfate to a thoroughbred mare, seven urine samples were obtained over a 45.5 h period. Using gas chromatography -electron impact ionization and positive-ion chemical ionization mass spectrometry, quinine and five putative metabolites were detected and tentatively identified in enzyme-hydrolysed post-administration urine; all metabolites involved some form of oxidation. The parent drug could be detected for about 16 h and some phase I biotransformation products for up to 40 h post-administration.
Demir
C
C
School of Chemistry, University of Bristol, Cantock's Close, UK.
Brereton
R G
RG
Dumasia
M C
MC
D000818:Animals; D001711:Biotransformation; D008401:Gas Chromatography-Mass Spectrometry; D006736:Horses / Q000652:urine*; D011803:Quinine / Q000493:pharmacokinetics / Q000652:urine*
D011803:Quinine