Characterization of a novel platelet-derived growth factor-associated protein.
A novel mitogen-associated protein was isolated from a rat neural retina cell line. The protein copurified with platelet-derived growth factor (PDGF)-A and was therefore termed PDGF-associated protein (PAP). cDNAs corresponding to the protein were characterized from both rat and human cDNA libraries. PAP binds to PDGF with low affinity and enhances the mitogenic effect of PDGF-A but lowers the mitogenic activity of PDGF-B. PAP mRNA is abundant in the brain of newborn rats and is found in several other tissues.
Fischer
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Salk Institute for Biological Studies, La Jolla, California, USA.
Schubert
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D016475:3T3 Cells / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000494:pharmacology; D020574:Proto-Oncogene Proteins c-sis; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; C103312:PDAP1 protein, human; C098600:Pdap1 protein, rat; D010750:Phosphoproteins; D010982:Platelet-Derived Growth Factor; D011518:Proto-Oncogene Proteins; D020574:Proto-Oncogene Proteins c-sis; D012333:RNA, Messenger; C075278:platelet-derived growth factor A; D013936:Thymidine