title: Exercise 201Tl/rest 99Tcm-tetrofosmin myocardial perfusion imaging: a convenient protocol for the assessment of coronary disease.
abstract: Standard exercise thallium-201 (201Tl)-redistribution protocols for the detection of coronary artery disease take about 4 h to complete. This is inconvenient for both patients and staff. The higher energy technetium-99m (99Tcm) emissions permit immediate imaging after 201Tl with minimal crosstalk. This study assessed exercise gated planar 201Tl scintigraphy (55 MBq) followed by rest gated planar 99Tcm-tetrofosmin scintigraphy (250 MBq) in 32 patients. The results showed a high sensitivity for the detection of coronary disease (100%) in this highly selective group of patients. In order to diagnose myocardial infarction accurately, it was necessary to view the gated 201Tl images and assess regional wall motion in a defect zone. This gave a specificity of 88% and a sensitivity of 71% for the prediction of myocardial infarction on the angiographic ventriculogram. Stress 201Tl/rest 99Tcm-tetrofosmin is a useful short protocol for patients unable to complete the full 4-h exercise 201Tl-redistribution study.
authors.affiliation: Department of Medical Cardiology, Royal Infirmary, Glasgow, UK.
authors.forename: S
authors.initials: S
authors.lastname: Woldman
authors.forename: A
authors.initials: A
authors.lastname: McQuiston
authors.forename: A
authors.initials: A
authors.lastname: Ng
authors.forename: W
authors.initials: W
authors.lastname: Martin
authors.forename: I
authors.initials: I
authors.lastname: Hutton
mesh_terms: D000328:Adult; D000368:Aged; D002985:Clinical Protocols; D017023:Coronary Angiography / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D005080:Exercise Test / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D013794:Thallium Radioisotopes; C078700:technetium tc-99m tetrofosmin