Conformational changes induced in the MHC class I molecule by peptide and beta 2-microglobulin.
Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule folds and begins its sojourn to the cell surface. To maintain its folded conformation, class I MHC requires peptide but not beta 2m, and the sequence of the peptide bound exercises a subtle influence on the structure of the class I molecule that is likely to be a factor in T cell receptor discrimination of MHC/peptide complexes.
Solheim
J C
JC
Department of Genetics, Washington University School of Medicine, St. Louis, Mo., USA.
Cook
J R
JR
Hansen
T H
TH
D000818:Animals; D017951:Antigen Presentation; D002135:Calcium-Binding Proteins / Q000378:metabolism; D037281:Calnexin; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000737:chemistry*; D051379:Mice; D018448:Models, Immunological; D008958:Models, Molecular; D010455:Peptides / Q000276:immunology; D011487:Protein Conformation; D017510:Protein Folding; D001613:beta 2-Microglobulin / Q000276:immunology*
D002135:Calcium-Binding Proteins; D015395:Histocompatibility Antigens Class I; D010455:Peptides; D001613:beta 2-Microglobulin; D037281:Calnexin