title: New anticancer agents in clinical development.
abstract: A better understanding of the biology and biochemistry of the cancer cell has led to the development of various promising new antineoplastic compounds that are now undergoing phase I, II, and III clinical testing. These drugs include topoisomerase I inhibitors, such as camptothecin and its analogs 9-aminocamptothecin, irinotecan, and topotecan; and the paclitaxel analog docetaxel. The authors discussed these new agents last month. In Part 2 of their article, they describe gemcitabine, an antimetabolite structurally related to cytarabine; fluorouracil prodrugs and other thymidylate synthase (TS) inhibitors, and new approaches to anticancer therapy, such as angiogenesis inhibitors, differentiating agents, signal transduction inhibitors, and gene therapy.
authors.affiliation: Cancer Therapy and Research Center, Institute for Drug Development, San Antonio, Texas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Eckardt
authors.forename: G
authors.initials: G
authors.lastname: Eckhardt
authors.forename: M
authors.initials: M
authors.lastname: Villalona-Calero
authors.forename: R
authors.initials: R
authors.lastname: Drengler
authors.forename: D
authors.initials: D
authors.lastname: Von Hoff
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use; D011355:Prodrugs / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use; D013876:Thiophenes / Q000627:therapeutic use; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011135:Polysaccharides, Bacterial; D011355:Prodrugs; D011799:Quinazolines; D013876:Thiophenes; D003841:Deoxycytidine; C079061:tecogalan; D005641:Tegafur; C073482:eniluracil; D014498:Uracil; D013940:Thymidylate Synthase; C068874:raltitrexed; D005472:Fluorouracil; D000093542:Gemcitabine