Synthesis and anticancer properties of pyrimido[4,5-b]quinolines.
The synthesis and antitumor properties of pyrimido[4,5-b]quinolines have been described starting from 4-arylamino-5-carboxy-2-hydroxy-6-methylpyrimidines by reaction with PPA or POCl3. The reduced pyrimidoquinolines and derivatives with alkylating function have also been obtained.
Długosz
A
A
Department of Organic Chemistry, University of Medicine, Faculty of Pharmacy, Grodzka, Poland.
Duś
D
D
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018922:HL-60 Cells; D019073:HT29 Cells; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007364:Intercalating Agents; D011743:Pyrimidines; D011804:Quinolines