Cdk inhibitors in development and cancer.
Activation of cyclin-dependent kinases is the primary control point of cell proliferation. Recent advances in the understanding of cell-cycle regulation have uncovered two families of proteins that bind and inhibit these kinases. These proteins are likely mediators of development and differentiation, and may provide molecular connections between the pathways of development and tumorigenesis.
Harper
J W
JW
Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA. jharper@bcm.tmc.edu
Elledge
S J
SJ
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004249:DNA Damage / Q000502:physiology; D016193:G1 Phase / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53; D018844:Cyclin-Dependent Kinases