Dose of propofol for laryngeal mask airway insertion in children: effect of premedication with midazolam.
We determined the dose-response curves and effective doses of propofol for insertion of the laryngeal mask airway (LMA) in 50 unpremedicated children and in 60 children premedicated with midazolam, aged 3-12 yr. One of several doses of propofol was administered i.v. over 15 s to groups of 10 children, and conditions for LMA insertion were assessed at 60 s. The dose-response curves were parallel (P = 0.94), but the curve for premedicated children was shifted significantly to the left of that for unpremedicated children and propofol requirements were reduced by one-third (P < 0.0001). The doses required for satisfactory LMA insertion in 50% and 90% of unpremedicated patients (ED50, ED90) (95% confidence interval) were 3.8 (3.4-4.2) mg kg-1 and 5.4 (4.7-6.8) mg kg-1, respectively; those for premedicated patients were 2.6 (2.2-2.8) mg kg-1 and 3.6 (3.2-4.3) mg kg-1, respectively.
Martlew
R A
RA
University Department of Anaesthesia, Royal Manchester Children's Hospital, Pendlebury.
Meakin
G
G
Wadsworth
R
R
Sharples
A
A
Baker
R D
RD
D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D017214:Laryngeal Masks; D008874:Midazolam / Q000494:pharmacology*; D011292:Premedication; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology
D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol