Hyalinizing trabecular adenoma of the thyroid--morphology and differential diagnosis.
Hyalinizing trabecular adenoma (HTA) is a rare but distinct type of thyroid neoplasm. Its typical morphological features are trabecular arrangement of tumour cells and the prominent hyaline appearance. Although cases of HTA with vascular and/or capsular invasion have been described, the vast majority of tumours are benign. This article deals with the histological, cytological, immunohistochemical, and ultrastructural features of HTA. The pitfalls of fine-needle aspiration biopsy and intra-operative frozen section examination are described. Finally the differential diagnostic aspects of HTA are discussed.
Schmid
K W
KW
Gerhard-Domagk-Institute of Pathology, University of Münster/Westfalia, Germany.
Mesewinkel
F
F
Böcker
W
W
D000236:Adenoma / Q000175:diagnosis / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D006801:Humans; D008854:Microscopy, Electron; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*
D014408:Biomarkers, Tumor