Structure of cytokine hydrophobic cores.
Diagrams were constructed that describe, using a common frame of reference, the interactions that occur within the hydrophobic cores of the left-handed four-helix bundles of interleukin-2, -4, -5, granulocyte/macrophage-, granulocyte-, macrophage-colony-stimulating factor, beta- and gamma-interferon, growth hormone, and leukemia inhibitory factor. Based on the assumption that the topologies of the ligand-receptor complexes are similar, analogous patterns were obtained from these diagrams and lead to the detailed comparison of the hydrophobic cores. These patterns were then used to obtain pairwise rigid-body superpositions among all of the four-helix bundles; values of the root-mean-square deviations (C alpha-atoms) over the four alpha-helices of the bundles range from 1.14 A to 3.22 A. Two distinct groups are formed after clustering based on structural superposition of the ten cytokines.
Denesyuk
A I
AI
Institute of Immunology, Lyubuchany, Moscow Region, Russia.
Johnson
M S
MS
Zav'yalov
V P
VP
Korpela
T
T
D016207:Cytokines / Q000737:chemistry* / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000737:chemistry; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000737:chemistry; D013006:Growth Hormone / Q000737:chemistry; D006131:Growth Inhibitors / Q000737:chemistry; D016899:Interferon-beta / Q000737:chemistry; D007371:Interferon-gamma / Q000737:chemistry; D007376:Interleukin-2 / Q000737:chemistry; D015847:Interleukin-4 / Q000737:chemistry; D015848:Interleukin-5 / Q000737:chemistry; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000737:chemistry; D016173:Macrophage Colony-Stimulating Factor / Q000737:chemistry; D015394:Molecular Structure; D018121:Receptors, Cytokine / Q000378:metabolism
D016207:Cytokines; D006131:Growth Inhibitors; D007376:Interleukin-2; D015848:Interleukin-5; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D018121:Receptors, Cytokine; D016179:Granulocyte Colony-Stimulating Factor; D015847:Interleukin-4; D016899:Interferon-beta; D016173:Macrophage Colony-Stimulating Factor; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D013006:Growth Hormone