[Soluble interleukin-2 receptor and macrophage colony-stimulating factor (M-CSF) in cerebrospinal fluid in patients with hematological malignancies: clinical significance in adult T-cell leukemia with meningeal infiltration].
We measured soluble interleukin-2 receptor (sIL-2R) and macrophage colony-stimulating factor (M-CSF) levels in the cerebrospinal fluid (CSF) of patients with hematological malignancies with or without meningeal infiltration and meningitis. Levels of sIL-2R and M-CSF in the CSF of adult T-cell leukemia (ATL) patients with meningeal infiltration were significantly higher than those of ATL patients without meningeal infiltration and non-ATL patients with meningeal infiltration. There was a significant positive correlation between sIL-2R levels and numbers of mononuclear cells in CSF of ATL patients with meningeal infiltration. However, M-CSF levels did not correlate with numbers of mononuclear cells. There was no correlation between CSF and serum levels of sIL-2R. There was also no correlation between sIL-2R and M-CSF in the CSF. Therefore, sIL-2R and M-CSF levels in the CSF may be useful in the diagnosis of meningeal infiltration in patients with ATL. In particular sIL-2R may be a sensitive marker.
Tanaka
K
K
First Department of Internal Medicine, Kurume University School of Medicine.
Shiraishi
K
K
Sakamoto
A
A
Fukahori
S
S
Jojima
H
H
Osabe
S
S
Mizunoe
K
K
Masuchi
K
K
Imamura
Y
Y
Honda
J
J
Egami
K
K
Natori
H
H
Oizumi
K
K
D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology*; D016173:Macrophage Colony-Stimulating Factor / Q000134:cerebrospinal fluid*; D008578:Meninges / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000175:diagnosis; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2; D016173:Macrophage Colony-Stimulating Factor