title: A new base substitution in the 5' regulatory region of the human Agamma globin gene is linked with the betaS gene.
abstract: A new T --> A base substitution, identified inside the 5' regulatory region of the human Agamma globin gene (Agamma-499 T -->A), is reported. This nucleotide change was found to be linked in cis with the mutation producing sickle cell anemia (CD6 GAG-->GTG: betaS gene).
authors.affiliation: Laikon General Hospital, Center for Thalassemia, Athens, Greece.
authors.forename: G P
authors.initials: GP
authors.lastname: Patrinos
authors.forename: A
authors.initials: A
authors.lastname: Loutradi-Anagnostou
authors.forename: M N
authors.initials: MN
authors.lastname: Papadakis
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D008040:Genetic Linkage / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D005914:Globins