title: Temporal lobe lesion-induced obesity in rats: an anatomical investigation of the posterior amygdala and hippocampal formation.
abstract: Bilateral lesions centered in the posterodorsal amygdala of female rats resulted in hyperphagia and excessive weight gain (mean = 65.3 g in 20 days compared to 6.8 g for control animals). The brain damage always extended posteriorly into the ventral hippocampal formation. However, lesions that were confined to the ventral hippocampus or amygdalohippocampal area had no effect on daily food intake or body weight, nor did lesions at any other hippocampal site. In a previous study, lesions of the basolateral, corticomedial, and anterior groups of amygdaloid nuclei failed to affect food intake or body weight. It is concluded that the posterodorsal aspect of the amygdala is the critical site for this experimentally induced obesity syndrome. New coordinates for the effective site are presented.
authors.affiliation: Department of Psychology, University of New Orleans, LA 70148, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: King
authors.forename: E R
authors.initials: ER
authors.lastname: Arceneaux
authors.forename: J T
authors.initials: JT
authors.lastname: Cook
authors.forename: A L
authors.initials: AL
authors.lastname: Benjamin
authors.forename: G F
authors.initials: GF
authors.lastname: Alheid
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology* / Q000502:physiology; D000818:Animals; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology; D009765:Obesity / Q000503:physiopathology*; D051381:Rats; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology