Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits.
Field stimulation relaxed the sphincter of Oddi muscle rings of the rabbit after incubation with phentolamine, oxprenolol and atropine (all 1 microM). The relaxation was blocked by NG-nitro-L-arginine methyl ester (30 microM) and was reversed by 3 mM L-arginine but not D-arginine. Sphincter of Oddi preparations from hypercholesterolaemic rabbits exhibited contractions under the same conditions. We conclude that nitrergic relaxation is impaired in the sphincter of Oddi from hypercholesterolaemic rabbits.
Szilvassy
Z
Z
First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Nagy
I
I
Szilvassy
J
J
Jakab
I
I
Csati
S
S
Lonovics
J
J
D000818:Animals; D002791:Cholesterol, Dietary / Q000494:pharmacology; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D011817:Rabbits; D009803:Sphincter of Oddi / Q000187:drug effects / Q000503:physiopathology*
D002791:Cholesterol, Dietary; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester