title: Protective effect of UL-409, a herbal formulation against physical and chemical factor induced gastric and duodenal ulcers in experimental animals.
abstract: UL-409, a herbal formulation, was investigated for its possible ulcero-protective activity in Wistar rats of either sex and male guinea pigs. Oral administration of UL-409 at a dose of 600 mg/kg significantly prevented the occurrence of cold-restraint stress induced ulcerations. It significantly inhibited gastric ulceration induced by alcohol and aspirin, as well as cysteamine and histamine induced duodenal ulcers in rats and guinea pigs, respectively. The volume and acidity of gastric juice in pyloric ligated rats was reduced by UL-409. It also significantly, and dose dependently, promoted gastric mucus secretion in normal as well as in stress, drug and alcohol induced ulceration in animals. On the basis of these observations, we conclude that UL-409 possesses antiulcer activity and that the observed activity may be due to the modulation of defensive factors by improvement in gastric cytoprotection.
authors.affiliation: R&D Centre, Himalaya Drug Co., Makali, Bangalore, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
authors.forename: S
authors.initials: S
authors.lastname: Gopumadhavan
authors.forename: T S
authors.initials: TS
authors.lastname: Hemavathi
authors.forename: T S
authors.initials: TS
authors.lastname: Muralidhar
authors.forename: M V
authors.initials: MV
authors.lastname: Venkataranganna
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D008515:Medicine, Ayurvedic; D010946:Plants, Medicinal; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents