title: Endogenous analgesia in the chicken.
abstract: Endogenous analgesia has been identified in mammals, but little is known about suppression of tonic pain following trauma or disease. Birds suffer from gouty arthritis which can be induced experimentally by intra-articular injection of sodium urate (SU) crystals. SU injection into the ankle joint of the chicken tested in cages resulted in pain-coping behaviour (one-legged standing, sitting) together with severe lameness. Birds kept and tested in large pens showed significantly less pain-coping behaviour, while birds tested in novel pens showed either complete analgesia or marked hypoalgesia, together with a significant reduction in lameness. Complete analgesia was observed during pre-laying behaviour. These results demonstrate a remarkable ability of birds to suppress such severe tonic pain as SU arthritis.
authors.affiliation: Roslin Institute Edinburgh, Scotland, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gentle
authors.forename: S A
authors.initials: SA
authors.lastname: Corr
mesh_terms: D000698:Analgesia; D000818:Animals; D000843:Ankle Joint / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002645:Chickens; D004195:Disease Models, Animal; D006073:Gout / Q000378:metabolism; D013997:Time Factors; D014527:Uric Acid / Q000494:pharmacology*
chemical_list: D014527:Uric Acid