title: Genome scanning for complex disease genes using the transmission/disequilibrium test and haplotype-based haplotype relative risk.
abstract: Two tests for allelic association were applied to a simulated complex disease for the Genetic Analysis Workshop 9. The transmission/disequilibrium test [Spielman et al., 1993] and the haplotype-based haplotype relative risk approach [Terwilliger and Ott, 1992] were used to detect disease-associated alleles in a set of 360 computer-simulated markers located on six chromosomes and genotyped in 200 nuclear families. This analysis emulates a genome-based search for linked markers. Computer simulations were also performed to clarify statistical properties of the TDT.
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY 10032, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Matise
mesh_terms: D000483:Alleles; D016009:Chi-Square Distribution; D002874:Chromosome Mapping; D003198:Computer Simulation; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005819:Genetic Markers; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D011237:Predictive Value of Tests; D018570:Risk Assessment
chemical_list: D005819:Genetic Markers