Anti-Hu antibody in a patient with Lambert-Eaton myasthenic syndrome and early detection of small cell lung cancer.
We report a patient with Lambert-Eaton myasthenic syndrome (LEMS) and anti-Hu antibody, which was an important clue in detecting small cell lung cancer (SCLC) at the early stage. This patient had no symptoms of anti-Hu associated paraneoplastic neurological syndrome. In LEMS patients in whom conventional tests fail to detect malignancy, anti-Hu antibody should be evaluated to diagnose SCLC at the early stage.
Tomiyasu
K
K
Department of Neurology, Kitasato University East Hospital, Sagamihara.
Ito
H
H
Kanazawa
N
N
Saito
T
T
Kowa
H
H
D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001426:Bacterial Proteins / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D004268:DNA-Binding Proteins / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D015624:Lambert-Eaton Myasthenic Syndrome / Q000097:blood / Q000276:immunology*; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D008297:Male
D000974:Antibodies, Antinuclear; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C040330:histone-like protein HU, bacteria