Androgens in the topical treatment of lichen sclerosus.
BACKGROUND
Testosterone propionate has been shown repeatedly to be effective in the treatment of vulvar lichen sclerosus, yet studies of androgens in serum of women with untreated vulvar lichen sclerosus suggested an abnormal activity of 5-alpha reductase in these patients. If impairment of 5-alpha reductase in women with untreated vulvar lichen sclerosus is a proximate cause of this disease, then dihydrotestosterone should be more effective than testosterone propionate in the treatment of the condition.


METHODS
To test this hypothesis, five women with vulvar lichen sclerosus received topically either dihydrotestosterone or testosterone propionate in a double-blind cross-over study.


RESULTS
These androgens appear to be equally effective in inducing objective improvement of the vulvar lichen sclerosus by both gross and microscopic criteria.


CONCLUSIONS
Impairment of 5-alpha reductase may not be germane to the pathogenesis of vulvar lichen sclerosus.
Paslin
D
D
Department of Dermatology, University of California at San Francisco School of Medicine, USA.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000627:therapeutic use; D001706:Biopsy; D018592:Cross-Over Studies; D013196:Dihydrotestosterone / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D013739:Testosterone / Q000008:administration & dosage* / Q000627:therapeutic use; D014844:Vulva / Q000187:drug effects / Q000473:pathology; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology
D018931:Antineoplastic Agents, Hormonal; D013196:Dihydrotestosterone; D013739:Testosterone; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase