Translocations in solid tumours.
Specific chromosomal translocations have now been identified in a variety of solid tumour types. Recent developments in this field include the identification of novel genes involved in the t(X;18) synovial sarcoma translocation and the discovery that the high-mobility group protein gene, HMGI-C, is involved in the chromosome 12 rearrangements found in lipomas and uterine leiomyomas. These discoveries may have important implications for the strategies used in tumour diagnosis and treatment.
Cooper
C S
CS
Haddow Laboratories, Sutton, Surrey, UK.
D006801:Humans; D008080:Liposarcoma / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000235:genetics*; D013584:Sarcoma, Synovial / Q000235:genetics*; D014178:Translocation, Genetic