Reversible cutaneous lymphoma occurring during methotrexate therapy.
A B-cell lymphoma, restricted to the skin, developed in a 58-year-old man receiving methotrexate for non-rheumatoid peripheral arthritis, with the simultaneous occurrence of a cytolytic hepatitis and carcinoma of the lung. Two weeks after methotrexate was stopped, both the skin tumour and the hepatitis disappeared spontaneously, with no recurrence during a 12-month follow-up period. Immunoglobulin gene rearrangement was shown by polymerase chain reaction (PCR) but in situ hybridization failed to reveal neoplastic cells positive for Epstein-Barr virus (EBV).
Viraben
R
R
Department of Dermatology, Purpan and La Grave Hospital, Toulouse, France.
Brousse
P
P
Lamant
L
L
D018501:Antirheumatic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
D018501:Antirheumatic Agents; D008727:Methotrexate