title: Transcription of the Y chromosomal gene, Sry, in adult mouse brain.
abstract: The Y chromosomal gene Sry encodes a putative transcription factor which appears to serve as a master switch initiating testicular development. Here we show that this gene is transcribed in hypothalamus, midbrain, and testis of adult male but not adult female mice. In contrast to its circular transcripts in adult testis, those in brain are linear and may be translated. We propose that Sry exerts a role in the regulation of sex differentiation of the mammalian nervous system.
authors.affiliation: Abteilung Anatomie and Zellbiologie, Universität Ulm, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Lahr
authors.forename: S C
authors.initials: SC
authors.lastname: Maxson
authors.forename: A
authors.initials: A
authors.lastname: Mayer
authors.forename: W
authors.initials: W
authors.lastname: Just
authors.forename: C
authors.initials: C
authors.lastname: Pilgrim
authors.forename: I
authors.initials: I
authors.lastname: Reisert
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D005815:Genetic Code; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012741:Sexual Maturation; D013737:Testis / Q000378:metabolism; D014158:Transcription, Genetic; D014998:Y Chromosome