[Interferon efficacy in treating patients with Astrakhan fever].
Astrakhan fever is a new endemic rickettsiosis belonging to the group of tick-borne spotted fevers. Adjuvant use of interferons in basic treatment of Astrakhan fever elevates its efficacy. The maximal contribution of interferons can be reached at administration of alpha-2 and gamma-interferons in daily doses 15,000-25,000 and 1500-2500 IU/kg, respectively. The response is higher at early administration of the medication. Interferons induce side effects early in the course: intensification of hyperthermia and pains.
Galimzianov
Kh M
KhM
Rasskazov
N I
NI
Altukhov
S A
SA
Mesniankin
A P
AP
Afanas'ev
S S
SS
Denisov
L A
LA
D000328:Adult; D000368:Aged; D001907:Boutonneuse Fever / Q000628:therapy*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage* / Q000009:adverse effects; D007371:Interferon-gamma / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D013997:Time Factors
D007370:Interferon Type I; D011994:Recombinant Proteins; D007371:Interferon-gamma
Effektivnost' interferonov pri lechenii bol'nykh astrakhanskoĭ likhoradkoĭ.