title: Mutagenicity of alkyl azides.
abstract: Alkyl azides showed mutagenicity for S. typhimurium TA100 strain with S9 mix. However, no significant activity was observed for TA98 either with or without S9 mix or for TA100 without S9 mix. On the other hand, 3-azido-1,2-propanediol showed the enantioselective activity regardless of S9 mix. Two aryl azides tested were not mutagenic, and trimethylsilyl azide exhibited potent activity for TA100. Their structure-activity relationships are discussed.
authors.affiliation: Graduate School of Nutritional & Environmental Sciences, University of Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Shiozawa
authors.forename: H
authors.initials: H
authors.lastname: Matsushita
authors.forename: Y
authors.initials: Y
authors.lastname: Terao
mesh_terms: D001386:Azides / Q000633:toxicity*; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D001386:Azides