Lymphocytes--their possible endocrine role in the regulation of fertility.
OBJECTIVE
Peptide secretion by peripheral lymphocytes obtained from fertile and infertile women.


METHODS
LH, FSH, and prolactin were estimated in the serum and culture supernatants obtained from Con-A stimulated human lymphocytes by RIA.


RESULTS
The levels of LH, FSH and prolactin were low in the culture supernatants obtained from lymphocytes of infertile women, when compared with proven fertile women.


CONCLUSIONS
The results indicated impairment in endocrine functions of lymphocytes obtained from infertile women. This impairment in lymphocyte function could be one of the causes of infertility in these women.
Shahani
S K
SK
Institute for Research in Reproduction (ICMR), Bombay, India.
Gupta
S M
SM
Meherji
P K
PK
D000328:Adult; D004702:Endocrine Glands / Q000276:immunology*; D005260:Female; D005298:Fertility / Q000276:immunology*; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology*; D010455:Peptides / Q000097:blood / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism
D010455:Peptides; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone