Screening a 2 cM genetic map for allelic association: a simulated oligogenic trait.
In this paper, we explore the use of a variety of familial transmission tests (and case-control analyses) to screen for allelic associations in simulated marker data of a quality (2 cM map) that will feasibly arise from genomic scans within the next 5-10 years. We demonstrate a form of the transmission-disequilibrium test extended to multiallele systems. The methods used were log-linear and related models implemented largely using standard statistical packages.
Duffy
D L
DL
Queensland Institute of Medical Research, Brisbane, Australia.
D000483:Alleles; D016022:Case-Control Studies; D002874:Chromosome Mapping / Q000379:methods; D003198:Computer Simulation; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D016012:Poisson Distribution
D005819:Genetic Markers