title: Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion.
abstract: The purpose of the present study was to assess the role of the liver in the plasma-cholesterol-lowering effect of soyabean lecithin. Normolipidaemic rats were fed on lecithin-enriched or control diets with the same amount of protein. The lecithin diets contained 200 g/kg high-fat commercial semi-purified soyabean lecithin (230 g/kg total lipids as soyabean phosphatidylcholine) or 200 g/kg high-fat purified soyabean lecithin (930 g/kg total lipids as soyabean phosphatidylcholine). The control diets were a lowfat diet (40 g fat/kg) and a high-fat triacylglycerol-rich diet (200 g fat/kg). The high-fat diets were isoenergetic. The cholesterol-lowering effect of the lecithin-enriched diets was associated with significantly lower levels of plasma total- and HDL-cholesterol and significantly higher levels of bile phosphatidylcholine (PC), bile salts and cholesterol. These findings suggest that the liver plays a major role in the reduction of plasma cholesterol, the increased biliary lipid being provided by both HDL and the hepatic microsomal pools of PC and cholesterol.
authors.affiliation: INSERM U130 and Laboratoire Central, Hôpital Sainte Marguerite, Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Polichetti
authors.forename: N
authors.initials: N
authors.lastname: Diaconescu
authors.forename: P L
authors.initials: PL
authors.lastname: De La Porte
authors.forename: L
authors.initials: L
authors.lastname: Malli
authors.forename: H
authors.initials: H
authors.lastname: Portugal
authors.forename: A M
authors.initials: AM
authors.lastname: Pauli
authors.forename: H
authors.initials: H
authors.lastname: Lafont
authors.forename: B
authors.initials: B
authors.lastname: Tuchweber
authors.forename: I
authors.initials: I
authors.lastname: Yousef
authors.forename: F
authors.initials: F
authors.lastname: Chanussot
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000032:analysis / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010713:Phosphatidylcholines / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max / Q000737:chemistry*
chemical_list: D001647:Bile Acids and Salts; D008076:Cholesterol, HDL; D010713:Phosphatidylcholines; D002784:Cholesterol