title: [Biomimetic oxidation of clemastine hydrogen fumarate].
abstract: The reaction of clemastine fumarate (1) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluoro-water. The reaction of 1 in aqueous solution with manganese(III)-5,10,15,20-tetrakis (pentafluorophenyl)-beta-tetrasulfonatoporphyrin chloride (MnTPFPS4PCl) as catalyst additional generates products of aromatic hydroxylation. Products were identified by TLC, UV, and MS. Thereby we found a close conformity with rat metabolism.
authors.affiliation: Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Fröhlich
authors.forename: B
authors.initials: B
authors.lastname: Pietzyk
authors.forename: K
authors.initials: K
authors.lastname: Smolinka
authors.forename: B
authors.initials: B
authors.lastname: Göber
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000493:pharmacokinetics*; D002855:Chromatography, Thin Layer; D002974:Clemastine / Q000737:chemistry* / Q000493:pharmacokinetics*; D003640:Dealkylation; D006900:Hydroxylation; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
chemical_list: D018926:Anti-Allergic Agents; D002974:Clemastine
vernacular_title: Untersuchungen zur biomimetischen Oxidation von Clemastinhydrogenfumarat.