title: Prognostic significance of circulating matrix metalloproteinase-2 to tissue inhibitor of metalloproteinases-2 ratio in recurrence of urothelial cancer after complete resection.
abstract: The relationship between the serum matrix metalloproteinase-2 (MMP-2):tissue inhibitor of metalloproteinases-2 (TIMP-2) ratio and disease recurrence was examined in 53 urothelial cancer patients with muscular invasion or with lymph node metastasis who underwent complete resection. The mean MMP-2:TIMP-2 ratio in 31 patients with recurrence was significantly higher than that in 22 patients without recurrence (P < 0.05). Disease-free survival of patients with high MMP-2:TIMP-2 ratios was extremely poor compared with that of patients with lower ratios (P < 0.01). Cox's multivariate analysis suggests that the serum MMP-2:TIMP-2 ratio would be a new independent prognostic indicator of urothelial cancer recurrence.
authors.affiliation: Department of Urology, Kobe University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Gohji
authors.forename: N
authors.initials: N
authors.lastname: Fujimoto
authors.forename: A
authors.initials: A
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: J
authors.initials: J
authors.lastname: Okawa
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
mesh_terms: D005260:Female; D018093:Gelatinases / Q000097:blood*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2; D008666:Metalloendopeptidases / Q000097:blood*; D015999:Multivariate Analysis; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D012008:Recurrence; D016019:Survival Analysis; D019716:Tissue Inhibitor of Metalloproteinase-2; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology
chemical_list: D011506:Proteins; D019716:Tissue Inhibitor of Metalloproteinase-2; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2