title: Flies on steroids--Drosophila metamorphosis and the mechanisms of steroid hormone action.
abstract: Recent studies have provided new insights into the molecular mechanisms by which the steroid hormone ecdysone triggers the larval-to-adult metamorphosis of Drosophila. Ecdysone-induced transcription factors activate large sets of secondary-response genes and provide the competence for subsequent regulatory responses to the hormone. It seems likely that similar hormone-triggered regulatory hierarchies exist in other higher organisms and that Drosophila is providing our first glimpses of the complexities of these gene networks.
authors.affiliation: Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA. carl.thummel@genetics.utah.edu
authors.forename: C S
authors.initials: CS
authors.lastname: Thummel
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development*; D004440:Ecdysone / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D007301:Insect Hormones / Q000502:physiology*; D008675:Metamorphosis, Biological / Q000235:genetics*; D013256:Steroids / Q000096:biosynthesis / Q000502:physiology; D014157:Transcription Factors / Q000096:biosynthesis
chemical_list: D007301:Insect Hormones; D013256:Steroids; D014157:Transcription Factors; D004440:Ecdysone