BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation.
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF-beta superfamily. Recent findings indicate that BMP-1 is identical to pro-collagen C-proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern formation during development. Taken together, current studies indicate that BMP-1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes.
Sarras
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Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160-7400, USA.
D000595:Amino Acid Sequence; D000818:Animals; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins; D002454:Cell Differentiation / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006128:Growth / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics / Q000502:physiology*
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins; D008666:Metalloendopeptidases; C525705:BMP1 protein, human; D055395:Bone Morphogenetic Protein 1; C071288:astacin