title: Carbohydrate metabolism in children receiving growth hormone for 5 years. Chronic renal insufficiency compared with growth hormone deficiency, Turner syndrome, and idiopathic short stature. Genentech Collaborative Group.
abstract: Carbohydrate metabolism was evaluated by fasting and postprandial glucose, insulin, and hemoglobin (Hb)Alc levels in children with chronic renal insufficiency and various other growth disorders treated with growth hormone. Mean fasting and postprandial glucose remained unchanged throughout the 5-year study period in all four study groups. Median fasting insulin levels rose from low-normal levels into the normal range after 5 years of growth hormone. Average fasting insulin level after 5 years was 10 mU/l. Median postprandial insulin values also rose, yet remained within the normal range at the 5-year mark. Mean Hb Alc levels remained within low to middle end of the normal range in the patients with growth hormone deficiency, Turner syndrome, and idiopathic short stature. Mean Hb Alc levels at the 5 years were slightly elevated to 6.3% for the patients with chronic renal insufficiency.
authors.affiliation: Division of Pediatric Endocrinology, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: P
authors.initials: P
authors.lastname: Saenger
authors.forename: K M
authors.initials: KM
authors.lastname: Attie
authors.forename: J
authors.initials: J
authors.lastname: DiMartino-Nardi
authors.forename: R N
authors.initials: RN
authors.lastname: Fine
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002648:Child; D002784:Cholesterol / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006130:Growth Disorders / Q000188:drug therapy / Q000378:metabolism*; D013006:Growth Hormone / Q000009:adverse effects* / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007328:Insulin / Q000097:blood; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D019518:Postprandial Period / Q000502:physiology; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014424:Turner Syndrome / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D013006:Growth Hormone; D007328:Insulin; D011188:Potassium; D012964:Sodium; D013974:Thyroxine; D014280:Triglycerides