[Subacute paraneoplastic cerebellar degeneration with anti-neuronal antibodies and gynecological cancers. A case report of a bilateral ovarian cancer where the classic "anti-YO" antibody is associated with another antineuronal antibody].
Subacute paraneoplastic cerebellar degeneration (SPCD) is a cerebellar syndrome associated with an identifiable or occult carcinoma without direct involvement of the nervous system by the cancer. This subacute syndrome is due to an extensive Purkinje cell destruction by anti-Purkinje cells autoantibodies. Some of them are specific for example "anti-YO" antibodies in gynecologic cancer situations. We report the case of a 50-year-old woman who presented an ovarien carcinoma revealed by a SPCD associated to an anti-Purkinje cell autoantibody "anti-YO" and to another unidentified autoantibody. Despite the treatment of the carcinoma, the invaliding SPCD did not regress. The diagnosis of SPCD requires identification and early treatment of the carcinoma, giving the patient the best chances for cure and avoiding major neurologic effects.
Tremouilhac
C
C
Clinique Chirurgicale, Hôpital G.-et-R.-Laennec, Nantes.
Hamy
A
A
De Ferron
E
E
Paineau
J
J
Visset
J
J
D000974:Antibodies, Antinuclear / Q000097:blood*; D002526:Cerebellar Diseases / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology*; D011689:Purkinje Cells / Q000276:immunology*
D000974:Antibodies, Antinuclear
Dégénérescence cérébelleuse subaiguë paranéoplasique avec anticorps antineuronaux et cancers gynécologiques. A propos d'une observation révélant un cancer ovarien bilatéral où le classique anticorps "anti-YO" est associé à un autre auto-anticorps antineuronal.