2-(2,3-dimethylchromon-6-yl) propanoic acid (OVS-103): a potent anti-inflammatory agent.
The compound OVS-103 showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It produced inhibition of the exudate volume and the migration of leucocytes in the carrageenan induced pleurisy test in rats. OVS-103 showed poor inhibitory effect on granuloma formation induced by cotton pellet and had no anti-pyretic and analgesic property. ALD50 in both rats and mice was more than 2000 mg/kg, p.o. and 1500 mg/kg, i.p.
Bani
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Pharmacology Department, Regional Research Laboratory, Jammu Tawi, India.
Singh
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Singh
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Singh
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OV
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D001168:Arthritis / Q000188:drug therapy; D002199:Capillary Permeability / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D010998:Pleurisy / Q000188:drug therapy; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000187:drug effects
C101008:2-(2,3-dimethylchromon-6-yl)propanoic acid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones