title: A two-step efficient chemoenzymatic synthesis of flavonoid glycoside malonates.
abstract: A simple and high-yielding protocol for the malonylation of some flavonoid glycosides is described. The two-step synthesis is based on the regioselective enzymatic introduction of a benzylmalonyl group by catalysis with the lipase from Candida antarctica, followed by Pd/C hydrogenolysis of the benzyl moiety.
authors.affiliation: CNR, Istituto di Chimica degli Ormoni, Milano, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Riva
authors.forename: B
authors.initials: B
authors.lastname: Danieli
authors.forename: M
authors.initials: M
authors.lastname: Luisetti
mesh_terms: D000215:Acylation; D002175:Candida / Q000201:enzymology; D005419:Flavonoids / Q000138:chemical synthesis*; D006027:Glycosides / Q000138:chemical synthesis; D008049:Lipase / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008314:Malonates / Q000138:chemical synthesis*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D005419:Flavonoids; D006027:Glycosides; D008314:Malonates; D008049:Lipase