Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report.
OBJECTIVE
To determine whether serum levels of vascular permeability factor (VPF) are elevated in patients with ovarian hyperstimulation syndrome (OHSS) and to determine if luteinizing granulosa cells may be a source of VPF.


METHODS
Prospective observational study.


METHODS
University IVF and GIFT program.


METHODS
Eight consecutive IVF and GIFT patients at high risk for OHSS.


METHODS
Vascular permeability factor concentration in serum and follicular fluid.


RESULTS
Serum VPF was significantly higher (15.2 +/- 4.0 pM; mean +/- SEM) on day +14 in the group who developed severe OHSS compared with those who did not. Follicular fluid VPF (171.5 +/- 18.5 pM) was approximately 100-fold greater than serum (1.7 +/- 1.3 pM) or peritoneal fluid (2.5 +/- 1.3 pM) 36 hours after hCG administration.


CONCLUSIONS
Vascular permeability factor is elevated in patients with severe OHSS and the ovary may be a source of VPF secretion.
Krasnow
J S
JS
Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
Berga
S L
SL
Guzick
D S
DS
Zeleznik
A J
AJ
Yeo
K T
KT
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D016228:Endothelial Growth Factors / Q000097:blood / Q000378:metabolism*; D005260:Female; D015571:Follicular Fluid / Q000378:metabolism; D006801:Humans; D008222:Lymphokines / Q000097:blood / Q000378:metabolism*; D009994:Osmolar Concentration; D016471:Ovarian Hyperstimulation Syndrome / Q000378:metabolism*; D010062:Ovulation Induction; D011446:Prospective Studies; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D006063:Chorionic Gonadotropin; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors