title: Total rectal resection, mesorectum excision, and coloendoanal anastomosis: a therapeutic option for the treatment of low rectal cancer.
abstract: BACKGROUND
  There is recent and sporadic evidence indicating that patients with very low rectal cancer may be treated via a sphincter-saving procedure, obviating the need for abdominoperineal resection and definitive colostomy. This study confirms these findings.
  
  
  METHODS
  From March 1990 to October 1994, 79 patients affected with primary low rectal cancers were submitted for total rectal resection, mesorectum excision, and coloendoanal anastomosis. All lesions were located within 8 cm of the anal verge (within 6 cm in 64 cases).
  
  
  RESULTS
  Eight patients relapsed at the pelvic level, and one patient only at the paraanastomotic site. Postoperative morbidity attributable to the procedure was low. A perfect continence was documented in 66% of cases after colostomy closure, and many patients (63%) had one or two bowel movements a day. Sixty-two patients of this series are alive, 49 without actual evidence of disease. Follow-up ranged from 2 to 56 months (median 23).
  
  
  CONCLUSIONS
  The clinical and pathological data derived from this study suggest that radical mesorectum excision more than a large clearance margin of resection remains the most important factor in reducing the incidence of local relapse after low rectal cancer surgery and that total rectal resection and coloendoanal anastomosis is a suitable and safe option to traditional, demolitive surgical techniques.
authors.affiliation: Division of General Surgery B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Leo
authors.forename: F
authors.initials: F
authors.lastname: Belli
authors.forename: S
authors.initials: S
authors.lastname: Andreola
authors.forename: M T
authors.initials: MT
authors.lastname: Baldini
authors.forename: G F
authors.initials: GF
authors.lastname: Gallino
authors.forename: R
authors.initials: R
authors.lastname: Giovanazzi
authors.forename: L
authors.initials: L
authors.lastname: Mascheroni
authors.forename: R
authors.initials: R
authors.lastname: Patuzzo
authors.forename: M
authors.initials: M
authors.lastname: Vitellaro
authors.forename: C
authors.initials: C
authors.lastname: Lavarino
authors.forename: R
authors.initials: R
authors.lastname: Bufalino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D003106:Colon / Q000601:surgery*; D003125:Colostomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D012007:Rectum / Q000601:surgery*; D015996:Survival Rate