[The evaluation of the time of gastric radio-isotopic emptying in subjects with non-insulin dependent diabetes mellitus].
Abnormal gastro-intestinal motility is a well-recognized complication of autonomic neuropathy in diabetics; delayed gastric emptying is frequently documented. Various pharmacologic agents have been used to treat this complication such as cisapride. We have evaluated the effects of cisapride on gastric emptying in nine diabetic patients with autonomic neuropathy through radio-scintigraphic method. Gastric emptying diabetic patients was significantly prolonged compared control subjects (p < 0.01). In our study cisapride increased gastric emptying, but this did not reach statistical significance. We concluded that cisapride may be considered as a good alternative in cases where limited efficacy or side effects preclude the use of metoclopramide.
Allegra
G
G
Insegnamento di Terapia Medica, Università di Palermo, Istituto di Clinica Medica.
Costa
R
R
Scaffidi
L
L
Campisi
D
D
Cangialosi
G
G
Scaffidi
A
A
D000368:Aged; D020117:Cisapride; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D011868:Radioisotopes; D013566:Sympathomimetics / Q000627:therapeutic use*
D010880:Piperidines; D011868:Radioisotopes; D013566:Sympathomimetics; D020117:Cisapride
Valutazione dei tempi di svuotamento gastrico radio-isotopico in soggetti con NIDDM in terapia con cisapride.