title: Haemodilution induces a hypercoagulable state.
abstract: It has been suggested that haemodilution with saline may increase whole blood coagulation. This study was conducted in two parts. First, we investigated the effect of in vitro dilution of blood with saline on whole blood coagulation as measured by the thrombelastogram (TEG). Blood (4 ml) was diluted with 0.9% saline 1 ml and coagulation compared with that of an undiluted control specimen obtained concurrently from the same subject. In the second part, the study was repeated using a modified gelatin colloidal solution (Haemaccel) as the diluent. The r time, k time and r + k time were decreased relative to control in both diluent groups. The alpha angles were increased compared with control in both groups while maximum amplitude was unchanged in the Haemaccel diluted group. We conclude that haemodilution per se increases the coagulability of whole blood in vitro, but that saline haemodilution has a more marked effect on final clot strength.
authors.affiliation: Department of Anaesthesia, University of Cape Town Medical School, South Africa.
authors.forename: T G
authors.initials: TG
authors.lastname: Ruttmann
authors.forename: M F
authors.initials: MF
authors.lastname: James
authors.forename: J F
authors.initials: JF
authors.lastname: Viljoen
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D006438:Hemodilution; D006801:Humans; D066298:In Vitro Techniques; D011097:Polygeline / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013916:Thrombelastography
chemical_list: D012965:Sodium Chloride; D011097:Polygeline