title: Modified substrates of DNA polymerases and design of antivirals.
abstract: The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Krayevsky
authors.forename: L A
authors.initials: LA
authors.lastname: Alexandrova
authors.forename: N B
authors.initials: NB
authors.lastname: Dyatkina
authors.forename: M K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: E A
authors.initials: EA
authors.lastname: Shirokova
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D003854:Deoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006678:HIV / Q000187:drug effects / Q000502:physiology; D006801:Humans; D019384:Nucleic Acid Synthesis Inhibitors; D012190:Retroviridae / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003854:Deoxyribonucleotides; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D004259:DNA-Directed DNA Polymerase