title: Erythrocyte oxidation in artificial Babesia gibsoni infection.
abstract: We have already reported that anti-erythrocyte antibody induced by Babesia gibsoni infection (aEAb) showed higher reactivity against aged and/or oxidized erythrocytes than intact one in vitro (Morita et al., 1995). To clarify the meaning of such a binding character of aEAb in vivo, changes in erythrocyte oxidation were observed in artificially infected dogs. The ratio of methemoglobin concentration against total hemoglobin concentration (metHb%) as the indicator of erythrocyte oxidation was increased by the artificial infection in the intact dogs, suggesting that aEAb played a more important role in erythrocyte destruction in infected dogs. Though parasitemia approximately three times higher was observed in splenectomized dogs than that in intact dogs, metHb% did not increase in the splenectomized dogs. This suggests that the spleen plays a very important role in erythrocyte oxidation in dogs infected with B. gibsoni.
authors.affiliation: Department of Parasitology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Saeki
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Ishii
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001404:Babesiosis / Q000097:blood* / Q000276:immunology; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000378:metabolism; D009996:Osmotic Fragility; D010084:Oxidation-Reduction; D013156:Splenectomy; D013997:Time Factors
chemical_list: D000913:Antibodies, Protozoan; D006454:Hemoglobins; D008706:Methemoglobin