title: Specificity of temporal amygdala atrophy in Alzheimer's disease: quantitative assessment with magnetic resonance imaging.
abstract: The aim of the study was to assess the specificity of temporal amygdala (TA) atrophy with magnetic resonance imaging (MRI) by comparing a group of early impaired patients with Alzheimer's disease (AD) with 'other types of dementia' and controls. In this prospective case-control study, 41 patients were selected: 12 with probable AD according to NINCDS-ADRDA and CERAD inclusion and exclusion criteria, 14 with other types of dementia and 15 age-matched control subjects. Two radiologists blindly measured the TA volumes on coronal oblique contiguous slices with a 1.5-tesla MRI scanner. TA volume measurements obtained by the 2 observers and right-left TA values were not significantly different. A significant TA atrophy was found in the AD group as compared to the other groups, with 39.7% (p < 0.001) difference in TA volumes between AD and other types of dementia groups and 41.4% (p < 0.0005) difference between AD and control groups. There was no significant difference between other types of dementia and control groups. There was an overlap between the three groups for 4 patients. TA atrophy assessed with MRI could be of diagnostic value in AD, especially in the early stage of the disease.
authors.affiliation: Service Hospitalier Frédéric Joliot, Orsay, France.
authors.forename: C
authors.initials: C
authors.lastname: Maunoury
authors.forename: J L
authors.initials: JL
authors.lastname: Michot
authors.forename: H
authors.initials: H
authors.lastname: Caillet
authors.forename: V
authors.initials: V
authors.lastname: Parlato
authors.forename: A
authors.initials: A
authors.lastname: Leroy-Willig
authors.forename: P
authors.initials: P
authors.lastname: Jehenson
authors.forename: A
authors.initials: A
authors.lastname: Syrota
authors.forename: F
authors.initials: F
authors.lastname: Boller
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000679:Amygdala / Q000033:anatomy & histology / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D016022:Case-Control Studies; D003704:Dementia / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D012016:Reference Values; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000473:pathology*