title: A controlled one-year trial of dextromethorphan in amyotrophic lateral sclerosis.
abstract: In a one-year parallel group double-blind placebo-controlled study of dextromethorphan (1.5 mg/kg) in amyotrophic lateral sclerosis, no significant differences were observed in the rate of progression (Norris scale) in comparing 24 patients randomly assigned to the dextromethorphan group and 25 patients randomly assigned to the placebo group. Of the 24 patients in the dextromethorphan group, 17 had limb onset and 7 had bulbar onset disease; average duration of disease was 12.5 +/- 6 months and sex ratio (M:F) was 1.4:1. Of the 25 patients in the placebo group, 18 had limb onset and 7 had bulbar onset disease; average duration of disease was 9.9 +/- 6 months and sex ratio (M:F) was 1.55:1. Dextromethorphan is a weak noncompetitive N-methyl-D-aspartate (NMDA) antagonist and higher doses or other potent NMDA receptor antagonists should be tested.
authors.affiliation: Department of Medical Pharmacology, Timone University Hospital, Marseille, France.
authors.forename: O
authors.initials: O
authors.lastname: Blin
authors.forename: J P
authors.initials: JP
authors.lastname: Azulay
authors.forename: C
authors.initials: C
authors.lastname: Desnuelle
authors.forename: F
authors.initials: F
authors.lastname: Billé-Turc
authors.forename: D
authors.initials: D
authors.lastname: Braguer
authors.forename: D
authors.initials: D
authors.lastname: Besse
authors.forename: E
authors.initials: E
authors.lastname: Branger
authors.forename: A
authors.initials: A
authors.lastname: Crevat
authors.forename: G
authors.initials: G
authors.lastname: Serratrice
authors.forename: J Y
authors.initials: JY
authors.lastname: Pouget
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D003915:Dextromethorphan / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003915:Dextromethorphan