title: Solvent effects on chemical processes. 11. Solvent effects on the kinetics of decarboxylative dechlorination of N-chloro amino acids in binary aqueous-organic solvents.
abstract: The phenomenological theory of solvent effects is extended to chemical reaction rates and is tested against experimental data on the decarboxylative dechlorination of N-chloroalanine and N-chloroleucine at 25 degrees C in binary aqueous-organic solvent mixtures. The organic cosolvents studied were methanol, ethanol, l-propanol, 2-propanol, ethylene glycol, propylene glycol, acetonitrile, and dioxane. Reaction rates increased in all cosolvent systems. The kinetic solvent effects could be quantitatively described by the theory, and the parameters of the theory (solvation exchange constants K1 and K2 and cavity surface area parameter delta g++) were found to possess magnitudes reasonable for the physical significance assigned to them. In particular, the delta g++ value is consistent with a recent measurement of the volume of activation delta V++ of the reaction.
authors.affiliation: School of Pharmacy, University Wisconsin-Madison 53706, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: LePree
authors.forename: K A
authors.initials: KA
authors.lastname: Connors
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007700:Kinetics; D008432:Mathematical Computing; D012996:Solutions; D012997:Solvents; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D006843:Hydrocarbons, Chlorinated; D012996:Solutions; D012997:Solvents; D014867:Water