Induction of chromosome aberrations in vivo in bone-marrow cells of mice by paracetamol.
The induction of chromosome aberrations by a common analgesic with antipyretic activity, Paracetamol, was investigated in vivo on bone-marrow cells of albino male mice. The drug was given orally or intraperitoneally in a single and cumulative dose series. The doses were the serial dilution of the highest one (400 mg/kg for intraperitoneal administration and 800 mg/kg for oral administration). Our study indicates that the cellular damage induced by Paracetamol leads to expression in chromosome aberrations such as gaps, chromatid breaks, acentric fragments and polyploid metaphases.
Severin
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Department of Biology and Genetics, Carol Davila, Medicine University, Bucharest.
Beleuta
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D000082:Acetaminophen / Q000008:administration & dosage / Q000633:toxicity*; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D007274:Injections, Intraperitoneal; D008297:Male; D008677:Metaphase; D051379:Mice; D016685:Mitomycin / Q000633:toxicity; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*
D018712:Analgesics, Non-Narcotic; D009153:Mutagens; D000082:Acetaminophen; D016685:Mitomycin