A review of dehydroepiandrosterone (DHEA).
Dehydroepiandrosterone (DHEA) is quantitatively the most abundant hormone in humans and mammals, with a wide variety of physiological effects, including major regulatory effects upon the immune system. Two of the most striking aspects of DHEA are a steady decline in DHEA with age and a significant deficiency in DHEA in patients with several major diseases, including cancer, atherosclerosis, and Alzheimer's disease. The hormone is secreted in a non-sulfated (DHEA) and sulfated form (DHEA-S). The two are apparently interchangeable, and it appears likely that its physiological effects are achieved by derivative molecules that have yet to be identified.
Shealy
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Shealy Institute, Springfield, MO 65803, USA.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000172:deficiency / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans
D003687:Dehydroepiandrosterone