Dammarane-type triterpenoid saponins from Bacopa monniera.
Three new dammarane-type triterpenoid saponins, bacopasaponins A, B and C, of biological interest have been isolated from the reputed Indian medicinal plant Bacopa monniera and identified as 3-O-alpha-L-arabinopyranosyl-20-O-alpha-L-arabinopyranosyl-+ ++jujubogenin, 3-O-[alpha-L-arabinofuranosyl (1--> 2)alpha-L-arabinopyranosyl]pseudojujubogenin and 3-O-[beta-D-glucopyranosyl (1 -->3)[alpha-L-arabinofuranosyl (1--> 2)]alpha-L-arabinopyranosyl]pseudojujubogenin by spectroscopic methods and some chemical transformations. The hitherto undetermined configurations at C-20 and C-22 of pseudojujubogenin were elucidated by phase-sensitive ROESY, and 1H and 13C signals of the saponins were assigned by DEPT, 1H-1H COSY, HSQC and HMBC techniques.
Garai
S
S
Indian Institute of Chemical Biology, Calcutta, India.
Mahato
S B
SB
Ohtani
K
K
Yamasaki
K
K
D002240:Carbohydrate Sequence; D007194:India; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*; D000097669:Dammaranes
D012503:Saponins; D013256:Steroids; D014315:Triterpenes; D000097669:Dammaranes