title: Biology of membrane transport proteins.
abstract: Membrane transporter proteins are encoded by numerous genes that can be classified into several superfamilies, on the basis of sequence identity and biological function. Prominent examples include facilitative transporters, the secondary active symporters and antiporters driven by ion gradients, and active ABC (ATP binding cassette) transporters involved in multiple-drug resistance and targeting of antigenic peptides to MHC Class I molecules. Transported substrates range from nutrients and ions to a broad variety of drugs, peptides and proteins. Deleterious mutations of transporter genes may lead to genetic diseases or loss of cell viability. Transporter structure, function and regulation, genetic factors, and pharmaceutical implications are summarized in this review.
authors.affiliation: School of Pharmacy, University of California, San Francisco 94143-0446, USA.
authors.forename: W
authors.initials: W
authors.lastname: Sadée
authors.forename: V
authors.initials: V
authors.lastname: Drübbisch
authors.forename: G L
authors.initials: GL
authors.lastname: Amidon
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D003001:Cloning, Molecular; D004298:Dopamine / Q000378:metabolism; D015394:Molecular Structure; D017421:Sequence Analysis
chemical_list: D018528:ATP-Binding Cassette Transporters; D004298:Dopamine