title: Radioimmunoguided surgery and colorectal cancer.
abstract: Radioimmunoguided surgery is a technique that aims to delineate the extent of epithelial neoplasms (primary/recurrent) and their spread (local, regional, and distant) which are not adequately visualized by conventional imaging techniques. The target lesion binds radiolabelled, tumour-associated monoclonal antibodies which are administered in the days before surgery and which bind to the target lesion. The radiotracer is detected intraoperatively using a hand-held gamma detecting probe. This identifies the extent of the tumour, involvement of lymph nodes or other organs and may allow a more complete surgical clearance of the tumour. This article provides a basic understanding of the RIGS (radioimmunoguided surgery) technique, the monoclonal antibodies which are used and outlines the advantages and limitations of this technique.
authors.affiliation: Department of General Surgical Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Aftab
authors.forename: H S
authors.initials: HS
authors.lastname: Stoldt
authors.forename: A
authors.initials: A
authors.lastname: Testori
authors.forename: A
authors.initials: A
authors.lastname: Imperatori
authors.forename: M
authors.initials: M
authors.lastname: Chinol
authors.forename: G
authors.initials: G
authors.lastname: Paganelli
authors.forename: J
authors.initials: J
authors.lastname: Geraghty
mesh_terms: D000911:Antibodies, Monoclonal; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D003107:Colorectal Surgery / Q000379:methods*; D006801:Humans; D007432:Intraoperative Period; D011379:Prognosis; D016719:Radioimmunodetection / Q000639:trends; D016019:Survival Analysis
chemical_list: D000911:Antibodies, Monoclonal