title: Theoretical study of stress-modulated growth in the aorta.
abstract: A theoretical model is presented for stress-modulated growth in the aorta. The model consists of a pseudoelastic tube composed of two layers representing the intima/media and the adventitia. Finite volumetric growth is included by letting the time-rate of change of the zero-stress dimensions of each volume element depend linearly on the local stresses. After analysing the model, we examine its fundamental growth response under changes in loads, material properties, and growth parameters. The behavior of the model is quite sensitive to changes in material nonlinearity and in the coefficients of the growth law. Next, growth of the aorta is simulated during development and maturity. For an appropriate choice of the parameters, the model exhibits patterns of growth that agree qualitatively with known characteristics of aortic growth. Comparison of model results with published experimental data during hypertension in the rat shows good agreement in the time course of the vessel radii and residual strain. Finally, the implications of the results are discussed in the context of deducing a general mechanical growth law for soft tissues. The proposed model should be useful in studies to determine the biomechanical factor that regulates growth.
authors.affiliation: Department of Mechanical Engineering, University of Rochester, NY 14627, USA. taber@me.rochester.edu.
authors.forename: L A
authors.initials: LA
authors.lastname: Taber
authors.forename: D W
authors.initials: DW
authors.lastname: Eggers
mesh_terms: D000818:Animals; D001011:Aorta / Q000254:growth & development*; D001696:Biomechanical Phenomena; D006973:Hypertension / Q000503:physiopathology; D008954:Models, Biological; D051381:Rats; D013314:Stress, Mechanical