title: Genetic epidemiology of the three predominant abnormal hemoglobins in India.
abstract: Hemoglobinopathies in India are Important public health problems. Of the several abnormal of hemoglobin molecules, there are three variants, viz. Sickle cell, hemoglobin E and hemoglobin D which are predominantly prevalent in India. The cumulative gene frequencies of these hemoglobins have been found to be 5.35% in India. The average gene frequency of sickle cell and hemoglobin D in India has been observed to be 4.3% and 0.86%, respectively. In the North Eastern region of India, the gene frequency of hemoglobin E is 10.9%. Gene frequencies and spatial distribution of the predominant abnormal hemoglobins in India have been discussed in variance with the previous generalisations.
authors.affiliation: Division of Community Health and Nutrition, Regional Medical Research Centre (ICMR), Orisa.
authors.forename: R S
authors.initials: RS
authors.lastname: Balgir
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D006446:Hemoglobin E / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006453:Hemoglobinopathies / Q000453:epidemiology / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D017720:Molecular Epidemiology; D015995:Prevalence
chemical_list: D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; D006446:Hemoglobin E