title: Validation of a method to study the dissolution behaviour of norfloxacin tablets.
abstract: This experimental study examines the development and validation of a new method to evaluate the dissolution rate of norfloxacin tablets. The volume of dissolution medium used here is 100 ml. instead of the 750-900 ml used in the official methods. This smaller volume is closer to that in the human gastric tract. Our main aim is to validate a device which, requiring small volumes of medium, allows the addition of therapeutic amounts of antacids or other substances for in vitro interaction dissolution studies.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Córdoba Borrego
authors.forename: M
authors.initials: M
authors.lastname: Córdoba Díaz
authors.forename: A
authors.initials: A
authors.lastname: Reillo Martín
authors.forename: J M
authors.initials: JM
authors.lastname: Cienfuegos Rodriguez
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D009643:Norfloxacin / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
chemical_list: D000890:Anti-Infective Agents; D009643:Norfloxacin