title: [Normalization of the prolactin values during alfa-interferon therapy: the considerations with a female patient with anti-HCV-positive chronic hepatitis and prolactin-secreting hypophyseal microadenoma].
abstract: We report the case of a 45-year-old woman suffering from anti-hepatitis C virus (HCV) positive chronic active hepatitis and amenorrhea-galactorrhea syndrome due to a prolactin-secreting pituitary microadenoma. She was repeatedly given alpha-interferon for hepatitis, and a concomitant normalization of plasma prolactin levels, with disappearance of the related symptoms, was observed during the treatment. Further experience is needed in order to verify the therapeutical effectiveness of alpha-interferon on prolactin-secreting tumors.
authors.affiliation: Divisione di Medicina Generale, Azienda ULSS n. 18, Ospedale di Rovigo.
authors.forename: R
authors.initials: R
authors.lastname: Zennaro
authors.forename: E G
authors.initials: EG
authors.lastname: Petracca
authors.forename: R
authors.initials: R
authors.lastname: Paolini
authors.forename: E
authors.initials: E
authors.lastname: Ramazzina
mesh_terms: D000236:Adenoma / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005260:Female; D006526:Hepatitis C / Q000097:blood / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000097:blood / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D011388:Prolactin / Q000097:blood* / Q000187:drug effects / Q000378:metabolism*; D011994:Recombinant Proteins; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011388:Prolactin
vernacular_title: Normalizzazione dei valori di prolattina in corso di terapia con alfa-interferon: considerazioni su una paziente affetta da epatite cronica anti-HCV positiva e microadenoma ipofisario prolattino-secernente.