title: Comparison of arterialized venous with arterial blood propofol concentrations during sub-anaesthetic infusions in volunteers.
abstract: We have compared propofol concentrations in arterial and arterialized venous blood (from the radial artery at the wrist and a vein in the opposite forearm) in five volunteers during a sub-anaesthetic increasing infusion regimen designed to produce pseudo-steady-state arterial concentrations of 0.06, 0.17 and 0.43 micrograms ml-1. As in a previous study, we found no statistically significant difference between sampling sites (P = 0.66). However, changes in the method of arterialization yielded a reduction in the observed variability, with the arterialized venous propofol concentration lying within +/- 23% (95% reference interval) of the corresponding arterial concentration compared with 1 +/- 43%, as reported previously.
authors.affiliation: Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Cardiff.
authors.forename: K R
authors.initials: KR
authors.lastname: Johnston
authors.forename: M D
authors.initials: MD
authors.lastname: Vickers
authors.forename: W W
authors.initials: WW
authors.lastname: Mapleson
mesh_terms: D000704:Analysis of Variance; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000097:blood*; D001800:Blood Specimen Collection / Q000379:methods*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000097:blood*; D017534:Radial Artery; D012039:Regional Blood Flow; D014680:Veins
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol