The SR protein family: pleiotropic functions in pre-mRNA splicing.
A family of proteins with arginine-serine-rich domains has recently come into the limelight of studies on the mechanisms of constitutive and regulated pre-mRNA splicing. Implicated in an ever increasing variety of functions, these proteins act as driving forces during spliceosome assembly and also play decisive roles in alternative splice-site selection, suggesting that they are crucial players in the regulation of splicing during cell differentiation and development.
Valcárcel
J
J
Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
Green
M R
MR
D000818:Animals; D001120:Arginine; D001665:Binding Sites; D004742:Enhancer Elements, Genetic; D006801:Humans; D008957:Models, Genetic; D010766:Phosphorylation; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D012694:Serine; D017381:Spliceosomes / Q000378:metabolism
D012322:RNA Precursors; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012694:Serine; D001120:Arginine