title: Histologic study of living response to artificially synthesized hydroxyapatite implant: 1-year follow-up.
abstract: We implanted artificially synthesized hydroxyapatite spheres into the orbits of 13 rabbits after enucleation. The spheres were removed 1, 2, 3, 6, and 12 months after implantation and examined by light and scanning electron microscopy. Tissue breakdown and exposure of the artificially synthesized hydroxyapatite implants were not observed. Month after month, fibrovascular tissues gradually invaded the pores of the artificially synthesized hydroxyapatite spheres deeper and deeper. Although the hydroxyapatite we used was completely artificially synthesized, we observed a mild foreign-body reaction around the artificially synthesized hydroxyapatite spheres. After 12 months, however, relief of the foreign-body reaction had occurred. Hydroxyapatite spheres for orbital implants after enucleation without scleral enveloping are appropriate.
authors.affiliation: Department of Ophthalmology, Nagasaki University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuda
authors.forename: I A
authors.initials: IA
authors.lastname: Bhutto
authors.forename: T
authors.initials: T
authors.lastname: Kitaoka
authors.forename: T
authors.initials: T
authors.lastname: Amemiya
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D017886:Durapatite / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000473:pathology*; D009915:Orbit / Q000601:surgery*; D019736:Prostheses and Implants; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite