title: [Modulation of the tumoral progression by anti-idiotypic antibodies of angiogenesis factors].
abstract: We took advantage of the anti-idiotypic strategy to design circulating probes mimicking the biological effects of VEGF (vascular endothelial growth factor) or FGF2 (fibroblast growth factor 2). The activation of the VEGF receptor KDR/flk-1 induced endothelial cell proliferation but not their migration, whereas that of the FGF receptor FGF-R1 gave opposite results. The long lasting delivery of KDR/flk-1 agonists, but not that of FGF-R1, in nude mice grafted with tumor fragments enhanced the tumor volume. Microscopic examination showed an increase in both the vascularization and the proliferation of cancer cells. In contrast, no difference in cell proliferation was observed within normal tissues.
authors.affiliation: Laboratoire de biologie moléculaire eucaryote, CNRS UPR 9006, Toulouse, France.
authors.forename: N
authors.initials: N
authors.lastname: Ortéga
authors.forename: F
authors.initials: F
authors.lastname: Jonca
authors.forename: S
authors.initials: S
authors.lastname: Vincent
authors.forename: C
authors.initials: C
authors.lastname: Favard
authors.forename: B
authors.initials: B
authors.lastname: Malavaud
authors.forename: N
authors.initials: N
authors.lastname: Bertrand
authors.forename: C
authors.initials: C
authors.lastname: Mazerolles
authors.forename: P
authors.initials: P
authors.lastname: Richmann
authors.forename: Y
authors.initials: Y
authors.lastname: Pouliquen
authors.forename: J P
authors.initials: JP
authors.lastname: Sarrammon
authors.forename: M M
authors.initials: MM
authors.lastname: Ruchoux
authors.forename: J
authors.initials: J
authors.lastname: Plouët
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D043925:Angiogenesis Inducing Agents / Q000276:immunology*; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D016228:Endothelial Growth Factors / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D043925:Angiogenesis Inducing Agents; D000888:Antibodies, Anti-Idiotypic; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D005346:Fibroblast Growth Factors
vernacular_title: Modulation de la progression tumorale par des anticorps anti-idiotypiques de facteurs angiogéniques.