title: Magnesium carbonate as a phosphorus binder: a prospective, controlled, crossover study.
abstract: The use of calcium carbonate (CaCO3) to bind phosphorus (P) in chronic hemodialysis patients has been a popular tactic in the past decade. Nonetheless, problems with hypercalcemia decrease its usefulness, particularly in patients treated with calcitriol. A P binder not containing calcium (Ca) would be of value in these circumstances. In short-term studies, we showed that magnesium carbonate (MgCO3) was well-tolerated and controlled P and Mg levels when given in conjunction with a dialysate Mg of 0.6 mg/dl. We, therefore, performed a prospective, randomized, crossover study to evaluate if the chronic use of MgCO3 would allow a reduction in the dose of CaCO3 and yet achieve acceptable levels of Ca, P, and Mg. We also assessed whether the lower dose of CaCO3 would facilitate the use of larger doses of calcitriol. The two phases were MgCO3 plus half the usual dose of CaCO3 and CaCO3 alone given in the usual dose. It was found that MgCO3 (dose, 465 +/- 52 mg/day elemental Mg) allowed a decrease in the amount of elemental Ca ingested from 2.9 +/- 0.4 to 1.2 +/- 0.2 g/day (P < 0.0001). The Ca, P, Mg levels were the same in the two phases. The maximum dose of i.v. calcitriol without causing hypercalcemia was 1.5 +/- 0.3 micrograms/treatment during the MgCO3 phase and 0.8 +/- micrograms/treatment during the Ca phase (P < 0.02). If these studies are confirmed, the use of MgCO3 and a dialysate Mg of 0.6 mg/dl may be considered in selected patients who develop hypercalcemia during treatment with i.v. calcitriol and CaCO3.
authors.affiliation: Renal Division, Washington University School of Medicine, Saint Louis, Missouri, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Delmez
authors.forename: J
authors.initials: J
authors.lastname: Kelber
authors.forename: K Y
authors.initials: KY
authors.lastname: Norword
authors.forename: K S
authors.initials: KS
authors.lastname: Giles
authors.forename: E
authors.initials: E
authors.lastname: Slatopolsky
mesh_terms: D000328:Adult; D000368:Aged; D001665:Binding Sites; D002117:Calcitriol / Q000008:administration & dosage; D002118:Calcium / Q000378:metabolism*; D002119:Calcium Carbonate / Q000008:administration & dosage; D018592:Cross-Over Studies; D004333:Drug Administration Routes; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D008274:Magnesium / Q000008:administration & dosage* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism*; D011446:Prospective Studies; D006435:Renal Dialysis
chemical_list: C005479:magnesium carbonate; D010758:Phosphorus; D002117:Calcitriol; D002119:Calcium Carbonate; D008274:Magnesium; D002118:Calcium