Linkage analysis between pericentrometric markers on chromosome 18 and bipolar disorder: a replication test.
Replication was attempted of a recent report on linkage between bipolar affective disorder and pericentrometric loci on chromosome 18. Linkage to these markers was excluded in a sample of five extended multiplex families using lod-score and affected-pedigree-member methods. In one family, however, the lod score exceeded 1.0. Although the proposed susceptibility genes are unlikely to have a major impact on the occurrence of bipolar disorder, they might modify the genetic risk in a minority of familial cases.
Maier
W
W
Department of Psychiatry, University of Bonn, Germany.
Hallmayer
J
J
Zill
P
P
Bondy
B
B
Lichtermann
D
D
Ackenheil
M
M
Minges
J
J
Wildenauer
D
D
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D002503:Centromere / Q000235:genetics*; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors
D005819:Genetic Markers