title: P3 and contingent negative variation in Parkinson's disease.
abstract: Patients with idiopathic Parkinson's syndrome, most of them in early stages of the disease, and matched healthy controls participated in a continuous performance task while their EEGs were recorded from 15 electrodes. During preparation of movements, a contingent negative variation (CNV) maximal at central and posterior sites was visible. This CNV was reduced in the patient population. A large P3-like positive deflection occurred after go and no-go stimuli that called for execution (go) or suppression (no-go) of a button press. Compared to healthy controls, the positive wave in Parkinson patients was significantly reduced after go stimuli and maximally attenuated when no-go stimuli had indicated to suppress the motor response. In contrast, P3 amplitudes after irrelevant "ignore' stimuli was not significantly reduced in the patients. These results are interpreted in the framework of a model of striatal function postulating (i) that populations of cortical and striatal neurons form distributed functional units (Hebbian cell assemblies), and (ii) that mutual inhibition between such cortico-striatal cell assemblies is mediated by the neostriatum, the forebrain structure primarily affected in Parkinson's disease.
authors.affiliation: Institut für Medizinische Psychologie und Verhaltensneurobiologie, Universität Tübingen, Germany. pumue@uni-tuebingen.de
authors.forename: F
authors.initials: F
authors.lastname: Pulvermüller
authors.forename: W
authors.initials: W
authors.lastname: Lutzenberger
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Mohr
authors.forename: J
authors.initials: J
authors.lastname: Dichgans
authors.forename: N
authors.initials: N
authors.lastname: Birbaumer
mesh_terms: D001519:Behavior / Q000502:physiology; D003265:Contingent Negative Variation; D004569:Electroencephalography; D006801:Humans; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009433:Neural Inhibition; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology