Multivariate analysis of the first 10 MEIC chemicals.
Nonlinear mapping coupled to powerful graphical tools was used to compare the toxicological responses of 32 in vivo and in vitro test systems to the first 10 MEIC chemicals. The obtained results clearly underline the usefulness of our methodological approach for the comparison of the different endpoints and the selection of a battery of in vitro toxicity tests allowing to estimate the possible harmful effects of chemicals in vivo.
Devillers
J
J
CTIS, Lyon, France.
Domine
D
D
Bintein
S
S
D016475:3T3 Cells / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D002460:Cell Line; D006801:Humans; D007928:Lethal Dose 50; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D015999:Multivariate Analysis; D018482:Muscle, Skeletal / Q000166:cytology / Q000187:drug effects; D017711:Nonlinear Dynamics; D051381:Rats; D013329:Structure-Activity Relationship; D018675:Toxicity Tests; D015262:Xenobiotics / Q000737:chemistry / Q000633:toxicity*
D015262:Xenobiotics