title: [MRI and computer-assisted tomography in Kufs disease. Apropos of a familial form].
abstract: Kufs disease is the adult form of ceroid neurolipofuscinosis, and an uncommon cause of degenerative nervous system disease affecting young adults. We present here 4 cases of family form revealed by a demential syndrome. In all 4 patients MRI showed diffuse cortical atrophy predominant in the parietal regions. In 3 of these 4 patients MRI also exhibited a low signal in T2-weighted sequences on the putamens. There was no abnormality of the white matter. Diagnosis was made by cerebral biopsy in one case and by rectal biopsy in all other cases. Although the MRI images are not specific, they must be used when the diagnosis of Kufs disease is suspected in young patients with demential syndrome.
authors.affiliation: Service de Neuroradiologie, CHU Bretonneau, Tours.
authors.forename: J P
authors.initials: JP
authors.lastname: Cottier
authors.forename: D
authors.initials: D
authors.lastname: Perrier
authors.forename: C B
authors.initials: CB
authors.lastname: Sonier
authors.forename: P
authors.initials: P
authors.lastname: Yapo
authors.forename: M M
authors.initials: MM
authors.lastname: Ruchoux
authors.forename: A
authors.initials: A
authors.lastname: Gelot
authors.forename: J
authors.initials: J
authors.lastname: Laffont
authors.forename: P
authors.initials: P
authors.lastname: Larmande
mesh_terms: D000328:Adult; D001284:Atrophy; D001706:Biopsy; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology; D003704:Dementia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009472:Neuronal Ceroid-Lipofuscinoses / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics*; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
vernacular_title: IRM et scanographie de la maladie de Kufs. A propos d'une forme familiale.