[Drug-induced kidney damage].
Drug-related renal damage is manifold in its origin, clinical picture and prognosis. The disorder can manifest itself as a purely functional phenomenon with tubular elimination of amino acids, enzymes, protein, glucose and electrolytes, or it is due to reversible hemodynamic changes; on the other hand, it may be accompanied by cell necrosis and inflammation. Hemodynamic, toxic, immunologic, or mechanically obstructive mechanisms or a combination of these play a pathogenetic role. It is important to know the renal parameters before and monitor them during treatment with nephrotoxic drugs; to avoid concomitant administration of two or more nephrotoxic drugs; and to make the diagnosis as well as terminate exposure rapidly.
Schwarz
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Medizinische Klinik des Universitätsklinikum, Benjamin Franklin, Berlin.
D000700:Analgesics / Q000009:adverse effects; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D003287:Contrast Media / Q000009:adverse effects; D016572:Cyclosporine / Q000009:adverse effects; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D016559:Tacrolimus / Q000009:adverse effects
D000700:Analgesics; D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D003287:Contrast Media; D016572:Cyclosporine; D016559:Tacrolimus
Medikamentös bedingte Nierenschäden.