Antibacterial and antifungal compounds from Kigelia pinnata.
A biologically monitored fractionation of the methanolic extracts of the root and fruits of Kigelia pinnata D.C. led to the isolation of the naphthoquinones kigelinone (1), isopinnatal (2), dehydro-alpha-lapachone (3), and lapachol (4) and the phenylpropanoids p-coumaric acid (5) and ferulic acid (6) as the compounds responsible for the observed antibacterial and antifungal activity of the root and kigelinone (1) and caffeic acid (7) from the fruits of this plant.
Binutu
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Adesogan
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Okogun
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D000880:Anthraquinones / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D005663:Furans / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000494:pharmacology; D010936:Plant Extracts; D018517:Plant Roots; D010946:Plants, Medicinal
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001952:Bridged-Ring Compounds; D002109:Caffeic Acids; D003373:Coumaric Acids; D005663:Furans; D009285:Naphthoquinones; D010936:Plant Extracts; C102767:isopinnatal; C102766:kigelinone; C004999:ferulic acid; C008252:lapachol; C040048:caffeic acid