title: [Low dose computerized tomography of the thorax. Experimental and clinical studies].
abstract: BACKGROUND
  Computed tomography is a significant source of medical radiation exposure for populations in Europe. Reduced radiation exposure may be possible with modern CT scanners with an image quality that while less good than before remains acceptable for clinical purposes. The lung appears particularly well suited to investigation with low-dose CT owing to the high contrast between normal and diseased pulmonary parenchyma.
  
  
  METHODS
  We analysed the diagnostic accuracy of different low-dose CT protocols for the detection of pulmonary nodules using inflation-fixed isolated postmortem lung specimens in a chest phantom. In a comparative patient study diagnostic accuracies of standard-dose CT (120 kV, 250 mAs; slice thickness 10 mm, pitch 1) and low-dose CT (120 or 140 kV, 50 mAs; slice thickness 5 or 10 mm, pitch 1 or 2) were assessed.
  
  
  RESULTS
  Preliminary results suggest that low-dose CT protocols with radiation exposure of 10-20% of that with standard-dose CT an reliably depict soft tissue density pulmonary nodules with a diameter of more than 5 mm and can also demonstrate smaller nodules equally well is many cases.
  
  
  CONCLUSIONS
  Low-dose CT may frequently be an adequate imaging procedure in a given clinical setting, particularly in young patients with benign disease.
authors.affiliation: Institut für Klinische Radiologie, Westfälische Wilhelms-Universität Münster.
authors.forename: S
authors.initials: S
authors.lastname: Diederich
authors.forename: H
authors.initials: H
authors.lastname: Lenzen
authors.forename: Z
authors.initials: Z
authors.lastname: Puskas
authors.forename: A T
authors.initials: AT
authors.lastname: Koch
authors.forename: T M
authors.initials: TM
authors.lastname: Yelbuz
authors.forename: M
authors.initials: M
authors.lastname: Eameri
authors.forename: N
authors.initials: N
authors.lastname: Roos
authors.forename: P E
authors.initials: PE
authors.lastname: Peters
mesh_terms: D006801:Humans; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000528:radiation effects; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*
vernacular_title: Niedrigdosiscomputertomographie des Thorax. Experimentelle und Klinische Untersuchungen.