title: Ultrastructure of the adipose tissue matrix in children with malnutrition.
abstract: Bioptic fragments of adipose white tissue taken from trochanterian area from children of 2-22 months old were ultrastructurally investigated. Children were of both sexes, 5 normal and 22 with clinical diagnosis of malnutrition. There were studied many interadipocyte spaces signalling out in cases with malnutrition modifications of different components, some of them related with the degree of malnutrition. There were noted: disorganisation and disappearance of basal membranes of capillaries and glycolema; modifications of endothelial cells with lesions of the capillary wall and free degraded red blood cells; disorganization of the ground substance in small areas or sometimes extended to all matrix of the space; collagen fibres reduced in number and size, and in two cases the presence of collagen fibrils with severe lesions, realeasing an electrondense material, fibrinoid-like; matrix infiltration, in some cases with lipids. In only one interadipocyte space a synaptic button was noted in contact with capillary. In malnutrition lesions of cellular elements of the white adipose tissue the following were observed: adipocytes, fibroblasts, fibrocytes, endothelial cells, mast cells--which in their turn are responsible for modifications of macromolecular structures of the extracellular matrix--glycosaminoglycans, proteoglycans, components of which biosyntheses are cell-dependent.
authors.affiliation: Department of Histology, University of Medicine and Pharmacy, Timişoara, România.
authors.forename: A
authors.initials: A
authors.lastname: Alexa
authors.forename: M
authors.initials: M
authors.lastname: Drăgan
authors.forename: I
authors.initials: I
authors.lastname: Popa
authors.forename: M
authors.initials: M
authors.lastname: Raica
authors.forename: E
authors.initials: E
authors.lastname: Dema
mesh_terms: D017667:Adipocytes / Q000473:pathology / Q000648:ultrastructure; D000273:Adipose Tissue / Q000166:cytology / Q000473:pathology* / Q000648:ultrastructure; D001706:Biopsy; D003238:Connective Tissue / Q000473:pathology* / Q000648:ultrastructure; D003239:Connective Tissue Cells; D005110:Extracellular Space; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D009748:Nutrition Disorders / Q000473:pathology*; D012016:Reference Values; D017154:Stromal Cells