title: On the development of an interstitial radiation protocol for a multicenter consortium. Experience with permanent low-dose rate and temporary high-dose rate 125I implants in 'failed' and 'newly diagnosed' glioblastoma patients: quality assurance methodology and a possible future adjuvant for therapeutic enhancement.
abstract: Three interstitial implant trial groups (one permanent low-dose rate 125I and two temporary high-dose rate 125I implants) in glioblastoma patients ('newly diagnosed' and 'failed') were compared to non-randomized similar control groups for efficacy. The results formed the basis for the BTCG 87-01 national implant trial. The 'pilot' trial demonstrated: 1) the effectiveness of a temporary high-dose rate 125I implant in 'failed' and 'newly diagnosed' patients; 2) the ability of a multicenter consortium to adhere to a standard protocol; 3) a methodology to insure quality assurance; and 4) the possibility of the future adjuvant application of hyperthermia using a single catheter system.
authors.affiliation: Center for Neuro-Oncology, Western Pennsylvania Hospital, Pittsburgh, USA.
authors.forename: R G
authors.initials: RG
authors.lastname: Selker
authors.forename: M S
authors.initials: MS
authors.lastname: Eddy
authors.forename: M
authors.initials: M
authors.lastname: Deutsch
authors.forename: V C
authors.initials: VC
authors.lastname: Arena
authors.forename: P
authors.initials: P
authors.lastname: Burger
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005909:Glioblastoma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D015918:Infusion Pumps, Implantable; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use*; D008875:Middle Aged; D011785:Quality Assurance, Health Care; D018714:Radiotherapy, Adjuvant; D012008:Recurrence; D012107:Research Design; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes