title: Systemic corticosteroids in the phenytoin hypersensitivity syndrome.
abstract: A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests. The use of systemic corticosteroids in this condition is not established. We report the resolution of all the features of PHS with systemic corticosteroids and recurrence on withdrawal, and further remission on reinstitution of systemic corticosteroids.
authors.affiliation: Department of Dermatology, University College London Hospitals, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Chopra
authors.forename: N J
authors.initials: NJ
authors.lastname: Levell
authors.forename: G
authors.initials: G
authors.lastname: Cowley
authors.forename: J J
authors.initials: JJ
authors.lastname: Gilkes
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D011239:Prednisolone / Q000627:therapeutic use*; D013577:Syndrome
chemical_list: D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D010672:Phenytoin; D011239:Prednisolone