Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases.
CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.
Novelli
M
M
Clinica Dermatologica I dell'Università di Torino, Italy.
Savoia
P
P
Fierro
M T
MT
Verrone
A
A
Quaglino
P
P
Bernengo
M G
MG
D000328:Adult; D000951:Antigens, Neoplasm / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000276:immunology; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology; D009182:Mycosis Fungoides / Q000276:immunology; D012751:Sezary Syndrome / Q000276:immunology; D012867:Skin / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology
D000951:Antigens, Neoplasm; D018819:Dipeptidyl Peptidase 4