[The effect of an alpha-tocopherol analog, MDL 73404, on myocardial bioenergetics].
The authors investigated the effect of the synthetic analogue of MDL 73,404 alpha-tocopherol on bioenergetic processes of the cardiac muscle in a control group of rats. After a 10-day application of the presented preparation they analyzed the following parameters of energetic metabolism: ATP, ADP, AMP and inorganic phosphorus. Beside these, the authors investigate the levels of main indicators of the purine metabolism (xanthine, hypoxanthine, inosine and uric acid) in the myocardium. Under the influence of the given analogue of alpha-tocopherol a significant increase in ATP, ADP and hypoxanthine took place in the myocardium. Also the total concentration of adenine nucleotide and relative ATP/ADP ratio increased in the cardiac muscle. On the basis of the gained results the authors came to a conclusion that the synthetic analogue of alpha-tocopherol MDL 73,404 has a favourable effect on the bioenergetic conditions in the myocardium. MDL 73,404 has a favourable cardioprotective effect on the cardiac muscle assumedly by means of stabilization of mitochondrial membranes on the myocardium with a subsequent impact on cellular ATP concentration.
Snircová
M
M
Farmakobiochemické laboratórium III. internej kliniky Lekárskej fakulty, Univerzity Komenského v Bratislave, Slovakia.
Kucharská
J
J
Herichová
I
I
Bada
V
V
Gvozdjáková
A
A
D000227:Adenine Nucleotides / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007288:Inosine / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D019820:Xanthine; D014970:Xanthines / Q000378:metabolism
D000227:Adenine Nucleotides; D002317:Cardiovascular Agents; D016166:Free Radical Scavengers; D007042:Hypoxanthines; D010710:Phosphates; D014970:Xanthines; C067190:MDL 73404; D014810:Vitamin E; D019820:Xanthine; D019271:Hypoxanthine; D007288:Inosine
Vplyv analógu alfatokoferolu MDL 73,404 na bioenergetiku myokardu.