Protein tyrosine phosphatases in signaling.
During the past few years, molecular cloning has established the existence of a structurally diverse family of intracellular and transmembrane protein tyrosine phosphatases (PTPases). The importance of PTPases in signaling is best understood in three model systems: the mammalian transmembrane CD45 PTPase, the Drosophila Src homology (SH)2 domain containing corkscrew PTPase and its vertebrate homolog SH-PTP2, and the mouse SH2-domain-containing hematopoietic cell PTPase. Whereas CD45, corkscrew and SH-PTP2 positively regulate tyrosine phosphorylation, the hematopoietic cell PTPase negatively regulates or terminates signaling. Recent data indicate that several transmembrane PTPases mediate cell adhesion, suggesting that they effect adhesion-specific signaling events.
Streuli
M
M
Division of Tumor Immunology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. Michel_Streuli@dfci.harvard.edu
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D011505:Protein-Tyrosine Kinases