title: Beta-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients.
abstract: Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between beta-endorphin (beta-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the beta-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.
authors.affiliation: Azienda Ospedaliera S. Camillo, Forlanini, Spallanzani, Roma.
authors.forename: F
authors.initials: F
authors.lastname: Spinazzola
authors.forename: C
authors.initials: C
authors.lastname: Barletta
authors.forename: G
authors.initials: G
authors.lastname: Demartino
authors.forename: F
authors.initials: F
authors.lastname: Martini
authors.forename: S
authors.initials: S
authors.lastname: Natili
authors.forename: P
authors.initials: P
authors.lastname: Noto
authors.forename: F
authors.initials: F
authors.lastname: Ferri
authors.forename: G
authors.initials: G
authors.lastname: Tossini
authors.forename: G
authors.initials: G
authors.lastname: Visco
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000328:Adult; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008875:Middle Aged; D001615:beta-Endorphin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone