title: Genomic and cDNA structures of the gene encoding the chicken ZF5 DNA binding protein.
abstract: Genomic and cDNA clones encoding the chicken ZF5 transcription factor were isolated and sequenced. Conceptual translation of the cDNAs indicates that chicken ZF5 has five zinc fingers at its C-terminal end and a POZ/BTB protein-interaction domain at its N-terminal end. These two functional domains are more than 99% identical in amino acid sequence between the chicken and mouse proteins, whereas the region separating the POZ/BTB and DNA binding domains is only 74% identical. The entire 458 amino acid open reading frame is contained within a single exon, except for the initiator methionine codon which alone is supplied from an upstream exon by mRNA splicing.
authors.affiliation: Department of Chemistry and Molecular Biology Institute, San Diego State University, CA 92182-1030, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Bhathal
authors.forename: W E
authors.initials: WE
authors.lastname: Stumph
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens / Q000235:genetics*; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D015698:Genomic Library; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D016335:Zinc Fingers
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D012097:Repressor Proteins