Treatment of cervix condylomata with alpha-IFN leucocytar.
The main viruses responsible for condyloma, a venereal disease, are the HPV 16 and 11. The stages of HPV infection are under the control of the immunitary system, which is inhibited by the virus itself. For this reason, the therapy of cervical condylomatosis is, at present, based on the use of interferon. The purpose of this study was to appreciate the activation of the immune system after therapy with interferon. We treated 12 women suffering from cervical condyloma and exocervical CIN with increasing doses of natural alpha-IFN injected intramuscularly, and also applied to the vagina. The clinical response to the therapy was total in 7 cases, partial in 4 cases and unsuccessful in I case. We also evaluated the percentage of inflammatory cells in the peripheral blood and at the level of the condylomatous lesions, After treatment the absolute and percentage number of inflammatory cells increased. Besides, at the level of the lesion the CD1 and CD4 cells also increased.
Zarcone
R
R
Department of Obstetrics and Gynecology, Second University of Naples, Italy.
Bellini
P
P
Cardone
G
G
Cardone
A
A
D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D003218:Condylomata Acuminata / Q000473:pathology / Q000628:therapy*; D004804:Eosinophils; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D018655:Lymphocyte Count; D008875:Middle Aged; D002577:Uterine Cervical Diseases / Q000473:pathology / Q000628:therapy*; D014622:Vaginal Creams, Foams, and Jellies; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000628:therapy*
D016898:Interferon-alpha; D014622:Vaginal Creams, Foams, and Jellies