Detection of genome similarity as an exploratory tool for mapping complex traits.
For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical by descent (IBD) conditional on observed marker data. These results can be generalized to multitrait-locus models. Thus, we can use conditional probability of genes shared IBD as a tool to reveal chromosomal segments that are likely to harbor the genes underlying the complex traits.
Guo
S W
SW
Department of Biostatistics, University of Michigan, Ann Arbor 48109-2029, USA.
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D011336:Probability
D005819:Genetic Markers