Reproductive factors and risk of uterine fibroids.
We analyzed the relation between reproductive history and risk of uterine fibroids using data from a case-control study. Cases were 621 women with histologically confirmed diagnosis of uterine fibroids. Controls were 1,051 non-hysterectomized patients. Compared with nulliparae, parous women had a relative risk (RR) of fibroids of 0.5 [95% confidence interval (CI) = 0.4-0.6], and the risk declined with number of births. The risk of fibroids also decreased with number of induced abortions (RR = 0.8 and 0.6 for women reporting one or two or more abortions, respectively). A total of 24 cases (3.9%) and 19 controls (1.8%) reported a history of infertility (RR = 2.0; 95% CI = 1.1-3.7).
Parazzini
F
F
Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.
Negri
E
E
La Vecchia
C
C
Chatenoud
L
L
Ricci
E
E
Guarnerio
P
P
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D007889:Leiomyoma / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D017584:Reproductive History; D012307:Risk Factors