title: Residential radon-222 exposure and lung cancer: exposure assessment methodology.
abstract: Although occupational epidemiological studies and animal experimentation provide strong evidence that radon-222 (222Rn) progeny exposure causes lung cancer, residential epidemiological studies have not confirmed this association. Past residential epidemiological studies have yielded contradictory findings. Exposure misclassification has seriously compromised the ability of these studies to detect whether an association exists between 222Rn exposure and lung cancer. Misclassification of 222Rn exposure has arisen primarily from: 1) detector measurement error; 2) failure to consider temporal and spatial 222Rn variations within a home; 3) missing data from previously occupied homes that currently are inaccessible; 4) failure to link 222Rn concentrations with subject mobility; and 5) measuring 222Rn gas concentration as a surrogate for 222Rn progeny exposure. This paper examines these methodological dosimetry problems and addresses how we are accounting for them in an ongoing, population-based, case-control study of 222Rn and lung cancer in Iowa.
authors.affiliation: Department of Preventive Medicine and Environmental Health, College of Medicine, University of Iowa, Iowa City 52242-5000, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Field
authors.forename: D J
authors.initials: DJ
authors.lastname: Steck
authors.forename: C F
authors.initials: CF
authors.lastname: Lynch
authors.forename: C P
authors.initials: CP
authors.lastname: Brus
authors.forename: J S
authors.initials: JS
authors.lastname: Neuberger
authors.forename: B C
authors.initials: BC
authors.lastname: Kross
mesh_terms: D000396:Air Pollutants, Radioactive / Q000008:administration & dosage / Q000032:analysis; D016902:Air Pollution, Indoor / Q000032:analysis*; D002274:Carcinogens, Environmental / Q000008:administration & dosage / Q000032:analysis; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods; D004812:Epidemiologic Methods; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology; D011829:Radiation Dosage; D011886:Radon / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D017687:Radon Daughters / Q000008:administration & dosage / Q000009:adverse effects; D018570:Risk Assessment
chemical_list: D000396:Air Pollutants, Radioactive; D002274:Carcinogens, Environmental; D017687:Radon Daughters; D011886:Radon