Increased serum concentrations of interleukin-1 beta in patients with coronary artery disease.
OBJECTIVE
To assess serum interleukin-1 beta (IL-1 beta) concentrations in patients with ischaemic heart disease, to characterise subgroups of patients with raised IL-1 beta concentrations, and to examine whether serum IL-1 beta concentrations correlate with non-specific indices of inflammation.


METHODS
Survey study of patients with ischaemic heart disease.


METHODS
Cardiac catheterisation laboratory of a tertiary medical centre.


METHODS
Consecutive patients with angina pectoris and patients recovering from uncomplicated acute myocardial infarction and undergoing elective coronary angiography.


RESULTS
Mean(SD) serum IL-1 beta concentrations were higher (P < 0.001) in patients with angina and < 50% coronary artery stenosis (n = 11; 18.8(19.9) pg/ml), patients with angina > or = 50% stenosis (n = 23; 10.2(11.4) pg/ml), and patients 8(0.8) days post-infarction (n = 13; 4.4(5.8) pg/ml) than in 15 healthy, age-matched controls (0.3(0.5) pg/ml). Serum IL-1 beta concentrations did not correlate with total blood leucocyte counts (r = -0.07, P = NS), blood lymphocyte counts (r = -0.24, P = NS), and blood monocyte counts (r = -0.29, P = NS), or with fibrinogen (r = -0.16, P = NS) and C-reactive protein concentrations (9(10.5) mg/dl v 14.1(19) mg/dl for patients with undetectable and detectable concentrations, respectively, P = NS).


CONCLUSIONS
Serum IL-1 beta concentrations are raised in patients with ischaemic heart disease, in particular in those with minimal coronary artery disease and angina. The precise role of IL-1 beta in coronary artery disease remains to be determined.
Hasdai
D
D
Department of Cardiology, Tel-Aviv University, Petah Tikva, Israel.
Scheinowitz
M
M
Leibovitz
E
E
Sclarovsky
S
S
Eldar
M
M
Barak
V
V
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000000981:diagnostic imaging; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000145:classification / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging
D007375:Interleukin-1