[Biomimetic oxidation of clemastine hydrogen fumarate].
The reaction of clemastine fumarate (1) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluoro-water. The reaction of 1 in aqueous solution with manganese(III)-5,10,15,20-tetrakis (pentafluorophenyl)-beta-tetrasulfonatoporphyrin chloride (MnTPFPS4PCl) as catalyst additional generates products of aromatic hydroxylation. Products were identified by TLC, UV, and MS. Thereby we found a close conformity with rat metabolism.
Fröhlich
L
L
Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany.
Pietzyk
B
B
Smolinka
K
K
Göber
B
B
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000493:pharmacokinetics*; D002855:Chromatography, Thin Layer; D002974:Clemastine / Q000737:chemistry* / Q000493:pharmacokinetics*; D003640:Dealkylation; D006900:Hydroxylation; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D018926:Anti-Allergic Agents; D002974:Clemastine
Untersuchungen zur biomimetischen Oxidation von Clemastinhydrogenfumarat.