Clinical evaluation of antineutrophil cytoplasmic autoantibodies in ANCA-associated diseases.
Antineutrophil cytoplasmic autoantibodies have been performed in 110 patients referred to the laboratory as a presumptive systemic vasculitis, idiopathic crescentic glomerulonephritis, inflammatory bowel disease or SLE with vascular manifestation. 25 patients were found to be positive with c-, or p-ANCA patterns in indirect immunofluorescent test. We describe several cases in which histological confirmation is not available, an early consideration of a positive ANCA test may offer a reliable diagnosis and effective therapeutic handling, while the cases when the test was not considered, the occurence of relapse was inevitable.
Cristea
A
A
Medical Clinic Nr. 1, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Badea
T
T
Bodizs
G
G
Olinic
N
N
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015267:Churg-Strauss Syndrome / Q000175:diagnosis; D003092:Colitis / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis; D005921:Glomerulonephritis / Q000175:diagnosis*; D006801:Humans; D007158:Immunologic Techniques; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000097:blood*; D014657:Vasculitis / Q000175:diagnosis*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D012697:Serine Endopeptidases; D053146:Myeloblastin