The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.
1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all age groups. 4. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The beta-end level in AL also increased in old rats. 5. Aging modified the haloperidol effect on beta-end level in AL and CCK level in NIL as the effect was only observed in young rats. 6. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL.
Lau
S M
SM
Department of Physiology, University of Hong Kong.
Tang
F
F
D000375:Aging / Q000378:metabolism; D000818:Animals; D002766:Cholecystokinin / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects*; D004744:Enkephalin, Methionine / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000187:drug effects*; D001615:beta-Endorphin / Q000187:drug effects*
D013373:Substance P; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D002766:Cholecystokinin; D006220:Haloperidol