title: Sib-based detection of QTLs.
abstract: Association and transmission/nontransmission analyses were used in a split sample design to identify disease susceptibility alleles at two loci. Sib-pair analysis on various subsets of the data identified an additional four regions that yielded signals of disease predisposing quantitative trait loci (QTLs). Three of these four regions represented Type I errors. A new simulation indicates that a multiplex sampling strategy would substantially improve QTL detection for this oligogenic transmission model.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Suarez
authors.forename: C L
authors.initials: CL
authors.lastname: Hampe
authors.forename: D
authors.initials: D
authors.lastname: O'Rourke
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: T
authors.initials: T
authors.lastname: Reich
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D018740:Genetic Heterogeneity; D005819:Genetic Markers; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D009679:Nuclear Family; D012984:Software
chemical_list: D005819:Genetic Markers