title: [The pathogenicity factors of Streptococcus pneumoniae strains causing meningitis].
abstract: Pneumococcal meningitis was registered in St. Petersburg in 1985-1991, morbidity rate being 1.7-2.3 cases per 100,000 children, including 7.4-19.8 cases among children under 1 year. Two thirds of the pneumococcal strains isolated in cases of meningitis belonged to serovars 19, 1, 6, 15 and 2. The comparative study of pneumococcal strains revealed that the presence of capsules, pneumolysin, high hyaluronidase activity or belonging to serovars 1 and 2 (irrespective of their hyaluronidase titers) were the most important factors contributing to the development of generalized infection. The role of such a factor as virulence for mice is not yet clear.
authors.forename: N N
authors.initials: NN
authors.lastname: Kostiukova
authors.forename: M O
authors.initials: MO
authors.lastname: Volkova
authors.forename: A S
authors.initials: AS
authors.lastname: Kvetnaia
authors.forename: V V
authors.initials: VV
authors.lastname: Ivanova
authors.forename: O P
authors.initials: OP
authors.lastname: Markov
mesh_terms: D000208:Acute Disease; D000818:Animals; D016667:Bacterial Capsules / Q000145:classification; D001426:Bacterial Proteins; D002353:Carrier State / Q000382:microbiology; D002648:Child; D003603:Cytotoxins / Q000032:analysis; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000032:analysis; D007928:Lethal Dose 50; D008586:Meningitis, Pneumococcal / Q000382:microbiology*; D051379:Mice; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000201:enzymology / Q000302:isolation & purification / Q000472:pathogenicity*; D013301:Streptolysins / Q000032:analysis; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D003603:Cytotoxins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D006821:Hyaluronoglucosaminidase
vernacular_title: Faktory patogennosti shtammov Streptococcus pneumoniae, vyzvavshikh meningit.