title: Refined exposure assessment for ingestion of tapwater contaminated with hexavalent chromium: consideration of exogenous and endogenous reducing agents.
abstract: Laboratory studies were conducted to determine how rapidly and completely chromium (VI) [Cr(VI)] is reduced upon contact with common beverages mixed with tapwater. Studies were performed for five common beverages (coffee, tea, orange juice, Kool Aid, and powdered lemonade) spiked with either 10 or 50 mg Cr(VI)/l. The concentrations of Cr(VI) were measured at several time intervals for up to four hours. It was demonstrated that each of these beverages had the capacity to reduce a concentration of > or = 8 mg Cr(VI)/l within a 15-minute time frame, and that continued monitoring of the beverages revealed greater reduction of the Cr(VI). These findings are consistent with the observation that many foods and beverages, as well as endogenous body fluids such as saliva and gastric juices, are capable of reducing substantial quantities of Cr(VI) to Cr(III). Our exposure assessment shows that the estimated high-end ingested dose of Cr(VI) from tapwater at both 1 and 5 mg Cr(VI)/l is generally two to three orders of magnitude below doses shown to have no adverse health effect in animal studies. When considered in conjunction with studies demonstrating that the reductive capacity of gastric juices may exceed 50 mg Cr(VI) daily, these observations suggest that little or no Cr(VI) is likely to be absorbed orally at a reasonable water concentration of Cr(VI), since tapwater is bright yellow at 5 mg Cr(VI)/l.
authors.affiliation: McLaren/Hart-ChemRisk, Irvine, CA 92714, USA.
authors.forename: B D
authors.initials: BD
authors.lastname: Kerger
authors.forename: R O
authors.initials: RO
authors.lastname: Richter
authors.forename: S M
authors.initials: SM
authors.lastname: Chute
authors.forename: D G
authors.initials: DG
authors.lastname: Dodge
authors.forename: S K
authors.initials: SK
authors.lastname: Overman
authors.forename: J
authors.initials: J
authors.lastname: Liang
authors.forename: B L
authors.initials: BL
authors.lastname: Finley
authors.forename: D J
authors.initials: DJ
authors.lastname: Paustenbach
mesh_terms: D000328:Adult; D001628:Beverages / Q000032:analysis*; D002675:Child, Preschool; D002857:Chromium / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry; D002957:Citrus / Q000737:chemistry; D003069:Coffee / Q000737:chemistry; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D019163:Reducing Agents / Q000032:analysis / Q000737:chemistry; D018570:Risk Assessment; D012989:Soil Pollutants / Q000008:administration & dosage / Q000032:analysis; D013662:Tea / Q000737:chemistry; D014881:Water Supply
chemical_list: D003069:Coffee; D019163:Reducing Agents; D012989:Soil Pollutants; D013662:Tea; D002857:Chromium