title: Regional localization of rat and mouse protein-tyrosine phosphatase PTP alpha/LRP gene (Ptpra) by fluorescence in situ hybridization.
abstract: Protein tyrosine phosphatases (PTPases) negatively regulate the effect(s) of protein tyrosine kinases and are implicated in the regulation of a variety of biological events including cell activation, differentiation, and neoplastic transformation. To gain insight into the role(s) of the PTPases, we mapped the gene encoding for the widely expressed receptor-like protein tyrosine phosphatase PTP alpha/LRP (locus symbol Ptpra) to rat chromosome 3q36 and mouse chromosome 2G by fluorescence in situ hybridization method. These results indicate that there is a conserved syntenic group between human 20p13, rat 3q36, and mouse 2G.
authors.affiliation: Department of Biology, Faculty of Science, Shiraz University, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Saadat
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: M C
authors.initials: MC
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000235:genetics; D002873:Chromosome Fragility; D002874:Chromosome Mapping / Q000379:methods*; D002890:Chromosomes, Human, Pair 20; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D016212:Transforming Growth Factor beta
chemical_list: C525718:BMP2 protein, human; C525719:Bmp2 protein, mouse; C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D016212:Transforming Growth Factor beta; D017027:Protein Tyrosine Phosphatases