title: Antitumorigenic activities of chalcones. I. Inhibitory effects of chalcone derivatives on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoyl-phorbol 13-acetate (TPA).
abstract: More than forty chalcone derivatives were synthesized to examine their structure-activity relationship against tumorigenesis. As a primary screening test, the inhibitory activities of the chalcones for the 32Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects.
authors.affiliation: Research Laboratory, Minophagen Pharmaceutical Co., Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iwata
authors.forename: T
authors.initials: T
authors.lastname: Nishino
authors.forename: N
authors.initials: N
authors.lastname: Nagata
authors.forename: Y
authors.initials: Y
authors.lastname: Satomi
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: S
authors.initials: S
authors.lastname: Shibata
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D047188:Chalcones; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D010743:Phospholipids / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D002599:Chalcone; C040920:isoliquiritigenin; D013755:Tetradecanoylphorbol Acetate