title: Airway reactivity of nose and bronchi in patients with nasal polyps.
abstract: The aim of the study was to determine whether patients with nasal polyps have a hyperreactive nasal mucosa and/or bronchi and whether there is any correlation between nasal and bronchial hyperreactivity. Twenty-six healthy volunteers and 10 consecutive patients with nasal polyps participated in the study. They were challenged with increasing concentrations of histamine. The nasal mucosa response was studied with rhinostereometry and the bronchial response was estimated by peak flow. One of the patients was mildly hyperreactive in the nose and 6 patients were hyperreactive in the bronchi. There was no correlation between nasal and bronchial hyperreactivity. Patients with nasal polyps do not have a hyperreactive nasal mucosa but there seems to be a high incidence of bronchial hyperreactivity in patients with nasal polyps.
authors.affiliation: Department of Otorhinolaryngology, Söder Hospital, Stockholm, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Hallén
authors.forename: P
authors.initials: P
authors.lastname: Graf
authors.forename: K G
authors.initials: KG
authors.lastname: Kölbeck
authors.forename: J E
authors.initials: JE
authors.lastname: Juto
mesh_terms: D000328:Adult; D000368:Aged; D001980:Bronchi / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000503:physiopathology*; D009298:Nasal Polyps / Q000503:physiopathology*
chemical_list: D006632:Histamine