title: Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups.
abstract: We report a cross-sectional study of 48 men, 56 premenopausal women, and 80 postmenopausal women who were of three ethnic/regional backgrounds: southern European (Greek, Italian), eastern European (Jewish, Polish, Hungarian), and western European (French, British). We determined bone mineral density (BMD) at four skeletal sites and assessed the vitamin D receptor (VDR) genotype by the Bsml restriction site polymorphism. Age and body mass index had significant effects on BMD by multiple regression analysis. In addition, ethnic/regional group had a significant effect on spinal BMD in premenopausal females (P = 0.014) and in males (P = 0.039). However, VDR genotype had no significant effect on BMD in any of the three study groups.
authors.affiliation: Department of Biochemistry and Molecular Biology, Thomas Jefferson Medical College, Philadelphia, Pennsylvania.
authors.forename: L D
authors.initials: LD
authors.lastname: Spotila
authors.forename: J
authors.initials: J
authors.lastname: Caminis
authors.forename: R
authors.initials: R
authors.lastname: Johnston
authors.forename: K S
authors.initials: KS
authors.lastname: Shimoya
authors.forename: M P
authors.initials: MP
authors.lastname: O'Connor
authors.forename: D J
authors.initials: DJ
authors.lastname: Prockop
authors.forename: A
authors.initials: A
authors.lastname: Tenenhouse
authors.forename: H S
authors.initials: HS
authors.lastname: Tenenhouse
mesh_terms: D015519:Bone Density / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D017698:Postmenopause; D017697:Premenopause; D011792:Quebec / Q000208:ethnology; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol