title: Angiogenesis as a new target for cancer treatment.
abstract: Neovascularization is often required for rapid growth of solid tumors and also limits vascular metastasis of tumor cells. Neovascularization-targeting agents are a recent innovation that may be a novel means of anticancer therapy. These antiangiogenic drugs have been developed by targeting cell proliferation of vascular endothelial cells, basement-membrane-degrading enzymes, angiogenic factors/receptors, extracellular matrix, angiogenesis signaling, and cell-cell/cell-matrix interactions. In this report, we describe how tumor angiogenesis occurs and how antiangiogenic agents are developed.
authors.affiliation: Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: H
authors.initials: H
authors.lastname: Izumi
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: D
authors.initials: D
authors.lastname: Goto
authors.forename: S
authors.initials: S
authors.lastname: Jimi
authors.forename: N
authors.initials: N
authors.lastname: Kawahara
authors.forename: T
authors.initials: T
authors.lastname: Shono
authors.forename: S
authors.initials: S
authors.lastname: Ushiro
authors.forename: M
authors.initials: M
authors.lastname: Ryuto
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Kuwano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents