Hypertension and the renin-angiotensin system in the congenital hydronephrosis rat with non-obstructive pelviureteric junction abnormalities.
We examined the involvement of the renin-angiotensin system in the maintenance of hypertension of the rat with congenital hydronephrosis having no urinary tract obstruction. The congenital hydronephrosis rat (HNR) had a significantly higher systolic blood pressure (181 +/- 9.5 mm Hg in the male bilateral hydronephrosis rat, BHN, at 13 weeks of age, n = 10) than control Wistar-Imamichi rats (126 +/- 5.8 mm Hg). The plasma renin activity and plasma angiotensin-II concentration of BHN were decreased to 20.1 and 24.6% of those of control rats, respectively. There was a negative correlation between plasma angiotensin-II concentration and blood pressure. In addition, the effect of captopril and indomethacin on the high blood pressure of BHNs was similar to that of human low-renin essential hypertension. These findings suggest that the renin-angiotensin system activity was markedly lowered and that the involvement of the system in the maintenance of hypertension in HNRs is small.
Tauchi
K
K
Physiology and Biochemistry Section, Imamichi Institute for Animal Reproduction, Ibaraki, Japan.
Kanehara
H
H
D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D006869:Hydronephrosis / Q000150:complications / Q000151:congenital* / Q000503:physiopathology; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology*; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D016861:Cyclooxygenase Inhibitors; D000804:Angiotensin II; D002216:Captopril; D012083:Renin; D007213:Indomethacin