title: Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder.
abstract: There is evidence that some schizophrenic patients have deficits on tests of cognitive function, particularly tests of executive function, including the Wisconsin Card Sorting Test (WCST) and the Trail-making Test, Part B. This study was conducted to determine the generalizability of these findings across the schizophrenia spectrum to schizotypal personality disorder (SPD). Forty DSM-III SPD patients, 56 nonschizophrenia-related other personality disorder (OPD) patients, and 32 normal volunteers from two medical centers performed tests of executive function such as the WCST, Trail-making Part B, Stroop Word-Color Test, and Verbal Fluency, as well as tests of more general intellectual functioning such as the Wechsler Intelligence Scale-Revised Vocabulary and Block Design subtests, and Trail-making Part A. SPD patients performed more poorly on the WCST and on Trail-making Part B than did OPD patients or normal subjects; the groups did not differ on tests of general intellectual functioning. SPD patients may share some of the cognitive deficits observed in schizophrenia.
authors.affiliation: Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY 10029-6574, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Trestman
authors.forename: R S
authors.initials: RS
authors.lastname: Keefe
authors.forename: V
authors.initials: V
authors.lastname: Mitropoulou
authors.forename: P D
authors.initials: PD
authors.lastname: Harvey
authors.forename: M L
authors.initials: ML
authors.lastname: deVegvar
authors.forename: S
authors.initials: S
authors.lastname: Lees-Roitman
authors.forename: M
authors.initials: M
authors.lastname: Davidson
authors.forename: A
authors.initials: A
authors.lastname: Aronson
authors.forename: J
authors.initials: J
authors.lastname: Silverman
authors.forename: L J
authors.initials: LJ
authors.lastname: Siever
mesh_terms: D000328:Adult; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010554:Personality Disorders / Q000175:diagnosis / Q000523:psychology; D011594:Psychometrics; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D014888:Wechsler Scales / Q000706:statistics & numerical data