Histamine-induced cytosolic calcium increase in porcine articular chondrocytes.
Chondrocytes have been shown to possess two types of histamine receptors, H1 and H2. The application of histamine to isolated porcine chondrocytes was found to significantly increase intracellular calcium and this increase was partially dependent upon the presence of extracellular calcium. This, therefore, implies that there is some role for a plasma membrane calcium transport system in the increase of cytosolic calcium in response to histamine. The increase in intracellular calcium in response to the application of histamine was found to be reduced by both H1 and H2 receptor antagonists.
Horwitz
E R
ER
Department of Physiology, University College Cork, Ireland. MDPY8004@IRUCCVAX.UCC.IE
Higgins
T M
TM
Harvey
B J
BJ
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism*; D002478:Cells, Cultured; D002744:Chlorpheniramine / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007811:Lanthanum / Q000378:metabolism; D011899:Ranitidine / Q000494:pharmacology; D011969:Receptors, Histamine H1 / Q000502:physiology; D015398:Signal Transduction; D013552:Swine
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D011969:Receptors, Histamine H1; D002744:Chlorpheniramine; D007811:Lanthanum; D006632:Histamine; D011899:Ranitidine; D002118:Calcium