title: Coronary reserve abnormalities in the infarcted myocardium. Assessment of myocardial viability immediately versus late after reflow by contrast echocardiography.
abstract: BACKGROUND
  The aim of this study was to determine whether myocardial contrast echocardiography (MCE) during exogenous vasodilation can accurately delineate infarct size, and hence the extent of myocardial viability, both immediately (15 minutes) and late (3 hours) after reperfusion when postreflow coronary hyperema is still present.
  
  
  RESULTS
  Twenty-one open-chest anesthetized dogs underwent 3 to 6 hours of coronary occlusion followed by reperfusion. MCE was performed 15 minutes after reflow before and during infusion of 0.2 mg.kg-1.min-1 adenosine i.v.. In 12 dogs, infarct size was measured at this time. In the remaining 9 dogs, reperfusion was continued for 3 hours, when MCE was repeated before and after an infusion of 0.56 mg.kg-1.min-1 dipyridamole i.v. and infarct size was measured. In the absence of adenosine, MCE perfusion defect at 15 minutes underestimated infarct sizes at both 15 minutes and 3 hours, whereas in the presence of adenosine, the estimate of infarct size was more accurate. Similarly, in the absence of dipyridamole, although MCE perfusion defect underestimated infarct size (both measured 3 hours after reflow), in the presence of dipyridamole, the estimate of infarct size was more accurate.
  
  
  CONCLUSIONS
  By unmasking abnormalities in flow reserve within the infarct bed, MCE in conjunction with coronary vasodilators can accurately predict infarct size both 15 minutes and 3 hours after reperfusion. Thus, MCE can be used for assessing the extent of myocardial viability both immediately and late after reperfusion when postreflow coronary hyperemia is still present.
authors.affiliation: Cardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA.
authors.forename: F S
authors.initials: FS
authors.lastname: Villanueva
authors.forename: G
authors.initials: G
authors.lastname: Camarano
authors.forename: S
authors.initials: S
authors.lastname: Ismail
authors.forename: N C
authors.initials: NC
authors.lastname: Goodman
authors.forename: J
authors.initials: J
authors.lastname: Sklenar
authors.forename: S
authors.initials: S
authors.lastname: Kaul
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D003326:Coronary Circulation; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D004452:Echocardiography; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology*; D012044:Regression Analysis; D013997:Time Factors; D014664:Vasodilation
chemical_list: D004176:Dipyridamole; D000241:Adenosine