Fibrin generation and digestion in patients with angina pectoris.
Fibrin generation and lysis were studied in 28 patients with angina pectoris (14 with active disease and 14 with inactive disease) and in 14 normal controls. The fibrinolytic response was evaluated by comparing the ratio between the plasma levels of fibrinopeptide A and fibrin degradation products. Levels of both were higher in patients than in controls (P < 0.001), with higher levels in active than in inactive disease (P < 0.001). The fibrinopeptide A/fibrin degradation products ratio was much higher (P < 0.001) in the active group than in other groups. Thus, in patients with angina pectoris, especially in the active state, the increased thrombin generation is not paralleled by an equivalent increase in fibrinolytic activity.
Prisco
D
D
Istituto di Clinica Medica Generale e Cardiologia, Università Degli Studi di Firenze, Florence, Italy.
Paniccia
R
R
Francalanci
I
I
Bandinelli
B
B
Filippini
M
M
Bacci
F
F
Rostagno
C
C
Abbate
R
R
Gensini
G F
GF
D000328:Adult; D000787:Angina Pectoris / Q000378:metabolism*; D001777:Blood Coagulation / Q000502:physiology; D005337:Fibrin / Q000096:biosynthesis / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D013917:Thrombin / Q000096:biosynthesis
D005338:Fibrin Fibrinogen Degradation Products; D005344:Fibrinopeptide A; D005337:Fibrin; D013917:Thrombin