title: Anthelmintic activity of 6,7-diaryl-pteridines.
abstract: In a search for new anthelmintic compounds, some 6,7-diaryl-pteridines were synthesized from the corresponding diaminopyrimidines and aromatic aldehydes. Their anthelmintic activity was tested in vitro against Caenorhabditis elegans and Heligmosomoides polygyrus and in vivo against Trichinella spiralis. Structure-activity relationships are discussed.
authors.affiliation: Instituto de Quimica Medico, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Ochoa
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez
authors.forename: M L
authors.initials: ML
authors.lastname: López García
authors.forename: A
authors.initials: A
authors.lastname: Ramón Martínez
authors.forename: M
authors.initials: M
authors.lastname: Mercedes Martínez
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009351:Nematospiroides dubius / Q000187:drug effects; D011621:Pteridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017160:Trichinella spiralis / Q000187:drug effects; D014235:Trichinellosis / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D011621:Pteridines