title: Respiratory scleroma: a clinicopathologic and ultrastructural study.
abstract: Respiratory scleroma (rhinoscleroma) is a chronic granulomatous infection produced by Klebsiella rhinoscleromatis, a gram-negative aerobic coccobacillus. This disease is endemic to Africa, Central and South America, South Central and Eastern Europe, the Middle East, and China. Sporadic cases have been reported in the United States, especially in persons who migrated from the aforementioned areas. The majority of cases affect the nose, but extension to the soft and hard palate, upper lip, and maxillary sinuses also is frequent. This study comprises 11 patients (6 females and 5 males) with respiratory scleroma identified over a 6-year period in Guatemala. Their ages ranged from 16 to 60 years. Light microscopy showed a dense plasmacytic infiltrate, Mikulicz histiocytes, and Russell bodies within the plasma cells. Ultrastructural study revealed Mikulicz histiocytes, cytoplasmic vacuoles containing bacilli, and so-called A and B granules. We favor the term respiratory scleroma for this lesion because it affects not only the nose but also the upper and lower respiratory tracts as well as the mouth.
authors.affiliation: School of Dentistry, University of Minnesota, Minneapolis, USA.
authors.forename: H O
authors.initials: HO
authors.lastname: Sedano
authors.forename: R
authors.initials: R
authors.lastname: Carlos
authors.forename: I G
authors.initials: IG
authors.lastname: Koutlas
mesh_terms: D000293:Adolescent; D000328:Adult; D003594:Cytoplasmic Granules / Q000382:microbiology; D005260:Female; D006644:Histiocytes / Q000382:microbiology / Q000648:ultrastructure; D006801:Humans; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D010159:Palate / Q000473:pathology; D010950:Plasma Cells / Q000382:microbiology / Q000648:ultrastructure; D012226:Rhinoscleroma / Q000382:microbiology / Q000473:pathology*; D009626:Terminology as Topic