[The effect of the secretory products of mononuclear phagocytes from patients in a control group and from patients suffering from acute nonlymphoblastic leukemias on the cells of the U-937 monoblastic line].
Effects of AML and normal mononuclear phagocyte conditioned media (CM) on the proliferation and differentiation of monoblastic human cell line U-937 have been studied. The normal mononuclear phagocyte CM inhibited proliferation and weakly stimulated differentiation of U-937 cells, whereas AML CM exerted no effect. Activation of both normal and AML macrophages with phorbol ether (TPA) was followed by enhancement of CM effect. TPA treatment corrected defects of secretory activity of AML mononuclear phagocytes. A possible role of different monokines in the regulation of proliferation and differentiation of leukaemic cells is discussed.
Lasunskaia
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EB
Machiulaĭtene
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Perekalina
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Freĭdlin
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D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D015846:Monokines / Q000187:drug effects / Q000378:metabolism / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D015846:Monokines; D013755:Tetradecanoylphorbol Acetate
Vliianie sekretornykh produktov mononuklearnykh fagotsitov patsientov kontrol'noĭ gruppy i stradaiushchikh ostrymi nelimfoblastnymi leĭkozami patsientov na kletki monoblastnoĭ linii U-937.