Mammalian artificial chromosomes.
The development of candidate vectors and of techniques for their manipulation by sequence targeting suggest that a mini-chromosome vector system for the mouse germline may be at hand. Mini-chromosome vectors should allow new sorts of genetic problems to be addressed experimentally and may accelerate the process of gene identification.
Brown
W
William Brown, Raoul Heller, Ming-Hong Shen and Aarti Chand, CRC Chromosome Molecular Biology Group, Biochemistry Department, Oxford University, South Parks Road, Oxford OX1 3QU, UK.
Heller
R
Loupart
ML
Shen
MH
Chand
A