(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
Cosford
N D
ND
SIBIA Neurosciences Inc., La Jolla, California 92037, USA.
Bleicher
L
L
Herbaut
A
A
McCallum
J S
JS
Vernier
J M
JM
Dawson
H
H
Whitten
J P
JP
Adams
P
P
Chavez-Noriega
L
L
Correa
L D
LD
Crona
J H
JH
Mahaffy
L S
LS
Menzaghi
F
F
Rao
T S
TS
Reid
R
R
Sacaan
A I
AI
Santori
E
E
Stauderman
K A
KA
Whelan
K
K
Lloyd
G K
GK
McDonald
I A
IA
D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D005260:Female; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009474:Neurons / Q000502:physiology*; D009865:Oocytes / Q000502:physiology; D018408:Patch-Clamp Techniques; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology*; D011994:Recombinant Proteins / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism; D014981:Xenopus
D000978:Antiparkinson Agents; D011725:Pyridines; D011759:Pyrrolidines; D011978:Receptors, Nicotinic; D011994:Recombinant Proteins; C100989:altinicline maleate