title: Three-component model of oestrogen formation and regulation of intratumoural oestrogen pool in breast neoplasms.
abstract: Although a two-component model system (i.e. epithelial and stromal spindle-shaped cells) may explain the regulation of aromatase activity and the location of possible intratumoural sources of oestrogen production in mammary neoplasms, a third component, consisting of lymphocytes and macrophages, may also be considered. Examples are presented, suggesting the importance of a three-component model for a more complete understanding of the regulation of oestrogen production in breast-tumour tissue.
authors.affiliation: Laboratory of Endocrinology, Professor NN Petrov Research Institute of Oncology, St Petersburg, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Berstein
authors.forename: R J
authors.initials: RJ
authors.lastname: Santen
authors.forename: S J
authors.initials: SJ
authors.lastname: Santner
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000378:metabolism; D004967:Estrogens / Q000096:biosynthesis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008954:Models, Biological; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology
chemical_list: D004967:Estrogens