title: CD4 deficiency in myelodysplastic syndrome with monosomy 7.
abstract: We describe a patient with myelodysplastic syndrome with monosomy 7 presenting with a T-cell defect. He suffered from infections from the age of 10 years, when a CD4 deficiency and impaired lymphoproliferative responses in vitro were found. The only symptom of a myelodysplastic syndrome at that time was thrombocytopenia with giant platelets. Monosomy 7 was found in the bone marrow cells. At the age of 11 years he developed other characteristics of monosomy 7 including splenomegaly and anaemia. Some months later leukaemia was diagnosed.
  
  
  CONCLUSIONS
  In non-HIV CD4 deficiency myelodysplastic syndrome has to be considered.
authors.affiliation: Department of Paediatrics, University Hospital Nijmegen, Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: F
authors.initials: F
authors.lastname: Preijers
authors.forename: G A
authors.initials: GA
authors.lastname: de Vaan
authors.forename: J A
authors.initials: JA
authors.lastname: Bakkeren
authors.forename: I S
authors.initials: IS
authors.lastname: Klasen
authors.forename: A
authors.initials: A
authors.lastname: Haraldsson
mesh_terms: D015704:CD4 Antigens / Q000097:blood*; D002648:Child; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000276:immunology*
chemical_list: D015704:CD4 Antigens