title: Methodological issues in the design of primary prevention trials.
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Gaziano
authors.forename: C H
authors.initials: CH
authors.lastname: Hennekens
authors.forename: J E
authors.initials: JE
authors.lastname: Buring
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D018890:Chemoprevention / Q000379:methods*; D004311:Double-Blind Method; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D019207:beta Carotene / Q000627:therapeutic use
chemical_list: D016588:Anticarcinogenic Agents; D010919:Placebos; D019207:beta Carotene