Atrial natriuretic peptide inhibits mesangial cell proliferation induced by early postnephrectomy serum.
Rat kidney mesangial or tubular cells were grown in tissue culture medium supplemented with sera of 20 sham-operated vs. 20 nephrectomized Charles River rats. Each cell sample was grown with or without addition of atrial natriuretic peptide (ANP) to the medium. ANP completely abolished the growth stimulatory effect of postnephrectomy serum [i.e., effect of renotropic factor(s) present in the serum] on mesangium cells. Tubular cell proliferation was unchanged. We propose that interaction between renotropin and atrial natriutetic peptide activity might be one of the possible mechanisms regulating compensatory renal growth following nephrectomy.
Averbukh
Z
Z
Nephrology Division of Assaf Harofeh Medical Center Affiliated to Sackler Medical School Tel-Aviv University Zerifin, Israel.
Berman
S
S
Weissgarten
J
J
Cohn
M
M
Modai
D
D
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D005260:Female; D005920:Glomerular Mesangium / Q000166:cytology* / Q000187:drug effects; D007684:Kidney Tubules / Q000166:cytology* / Q000187:drug effects; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
D003470:Culture Media; D009320:Atrial Natriuretic Factor