Effects of dicarboxylic acids on fatty acid-metabolizing enzymes in cultured rat hepatocytes.
A clear chain-length dependent effect was observed for peroxisomal fatty acid beta-oxidation and carnitine acetyltransferase and also for mitochondrial carnitine palmitoyltransferase in primary cultures of rat hepatocytes. The extent of modulation of peroxisomal beta-oxidation was higher with even-carbon numbered dicarboxylic acids than with odd-carbon numbered ones, although such a tendency was not detected in the mitochondrial reactions. These results indicate difference in the effect of fatty acid-derived dicarboxylates on peroxisomal and mitochondrial functions.
Sato
T
T
Department of Pharmacology, Keio University, Tokyo, Japan.
Murayama
N
N
Yamazoe
Y
Y
Kato
R
R
D000818:Animals; D002333:Carnitine Acyltransferases / Q000378:metabolism*; D002478:Cells, Cultured; D002994:Clofibrate / Q000494:pharmacology; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003998:Dicarboxylic Acids; D005227:Fatty Acids; D010088:Oxidoreductases; D002333:Carnitine Acyltransferases; D002994:Clofibrate