Effect of enzyme organization on the stability of Yates-Pardee pathways.
Yates-Pardee-type metabolic pathways in a heterogeneous cell milieu are modeled as a system of coupled non-linear partial differential equations. A numerical solution to this system is described and some properties of such a physiological system are studied. Confinement with and without a membrane is considered and it is shown how confinement results in an increase in the stability of the metabolite concentrations. These results suggest that the enzyme organization may contribute to the stability of the cellular metabolism.
Costalat
R
R
Institut de Biologie Théorique, Angers, France. ybteam@snv.jussieu.fr
Burger
J
J
D002451:Cell Compartmentation; D004795:Enzyme Stability; D004798:Enzymes / Q000378:metabolism*; D008433:Mathematics; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D017711:Nonlinear Dynamics
D004798:Enzymes; D009097:Multienzyme Complexes