201Tl and 99Tcm-human serum albumin for assessment of the effect of hypertensive treatment with angiotensin II infusion on tumour circulation.
The biodistribution of 201Tl and of 99Tcm-human serum albumin (99Tcm-HSA) was observed in tumour-bearing mice to investigate if tissue blood circulation could be evaluated in groups of mice infused with angiotensin II at a rate of 0.5 micrograms kg-1 min-1 (L) or 1 microgram kg-1 min-1 (H). Ten minutes after tracer injection, tumour uptake of 201Tl in the angiotensin II infused group showed a 2.20- and a 3.18-fold increase in the L and H groups, respectively, when compared to a group of mice infused with saline (P = 0.0478 and 0.0029, respectively). The effect of angiotensin II infusion on 201Tl uptake was minimal in normal organs. Decreased normal organ uptake of simultaneously injected 99Tcm-HSA in the L and H groups indicated the contraction of normal organ vessels, while increased tumour uptake of the tracer indicated mechanical dilatation of tumour vessels. We conclude that the effect of angiotensin II or other vasoactive agents can be non-invasively assessed by 201Tl and 99Tcm-HSA scintigraphy.
Kinuya
S
S
Department of Nuclear Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan.
Yokoyama
K
K
Konishi
S
S
Hwang
E H
EH
Takayama
T
T
Michigishi
T
T
Tonami
N
N
D000804:Angiotensin II / Q000008:administration & dosage*; D000818:Animals; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013794:Thallium Radioisotopes
D013668:Technetium Tc 99m Aggregated Albumin; D013794:Thallium Radioisotopes; D000804:Angiotensin II