title: The structural role of sugars in glycoproteins.
abstract: To date, high resolution X-ray structures of about 30 glycoproteins have been reported that provide some structural information on glycans. Four solution structures of glycoproteins have been described over the past three years. In all four of these cases, it was shown that glycosylation is stabilizing the glycoprotein structures, indicating that this may be a general glycan function.
authors.affiliation: Procept Inc., Cambridge, MA 02139, USA. dwyss@procept.com
authors.forename: D F
authors.initials: DF
authors.lastname: Wyss
authors.forename: G
authors.initials: G
authors.lastname: Wagner
mesh_terms: D001665:Binding Sites; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry* / Q000145:classification; D018360:Crystallography, X-Ray; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011487:Protein Conformation
chemical_list: D002241:Carbohydrates; D006023:Glycoproteins