T-lymphocyte cholecystokinin-8 and beta-endorphin concentrations in eating disorders: I. Anorexia nervosa.
Baseline concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) were measured in T-lymphocytes from 33 restricting patients with anorexia nervosa (AN-R), 23 binging/purging patients with anorexia nervosa (AN-BP), and 24 healthy volunteers. CCK-8 basal values were significantly lower and beta-EP values significantly higher in AN-R and AN-BP patients than in normal volunteers. Levels of the peptides were measured three more times during a 4-month combined cognitive-behavioral/psychopharmacological treatment (nortriptyline or fluoxetine in AN-R, fluoxetine or amineptine in AN-BP). CCK-8 values fluctuated (nonsignificantly) during each treatment, while beta-EP values decreased (to a significant degree only in fluoxetine-treated AN-R patients).
Brambilla
F
F
Centro di Psiconeuroendocrinologia, Ospedale Psichiatrico Pini, Milan, Italy.
Brunetta
M
M
Peirone
A
A
Perna
G
G
Sacerdote
P
P
Manfredi
B
B
Panerai
A E
AE
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000628:therapy; D000928:Antidepressive Agents / Q000008:administration & dosage; D002648:Child; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003986:Dibenzocycloheptenes / Q000008:administration & dosage; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage; D006801:Humans; D009661:Nortriptyline / Q000008:administration & dosage; D012844:Sincalide / Q000097:blood*; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D016896:Treatment Outcome; D001615:beta-Endorphin / Q000097:blood*
D000928:Antidepressive Agents; D003986:Dibenzocycloheptenes; D005473:Fluoxetine; C011597:amineptin; D001615:beta-Endorphin; D009661:Nortriptyline; D012844:Sincalide