title: Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization.
abstract: African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization.
authors.affiliation: Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Gómez-Puertas
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez
authors.forename: J M
authors.initials: JM
authors.lastname: Oviedo
authors.forename: F
authors.initials: F
authors.lastname: Ramiro-Ibáñez
authors.forename: F
authors.initials: F
authors.lastname: Ruiz-Gonzalvo
authors.forename: C
authors.initials: C
authors.lastname: Alonso
authors.forename: J M
authors.initials: JM
authors.lastname: Escribano
mesh_terms: D000357:African Swine Fever / Q000821:virology*; D000358:African Swine Fever Virus / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology* / Q000494:pharmacology; D013552:Swine; D014764:Viral Proteins / Q000276:immunology*; D014779:Virus Replication / Q000187:drug effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014764:Viral Proteins