A novel genital human papillomavirus (HPV), HPV type 74, found in immunosuppressed patients.
The genome of a novel human papillomavirus (HPV) type, HPV74, was cloned from an iatrogenically immunosuppressed woman with persisting low-grade vaginal intraepithelial neoplasia. HPV74 was found to be phylogenetically related to the low-risk HPV types 6, 11, 44, and 55. HPV74 or a variant of this type was found in specimens from three additional immunosuppressed women but not in about 3,000 anogenital specimens from immunocompetent patients.
Longuet
M
M
Unité Mixte Institut Pasteur, Paris, France.
Cassonnet
P
P
Orth
G
G
D001483:Base Sequence; D015139:Blotting, Southern; D002278:Carcinoma in Situ / Q000276:immunology / Q000821:virology; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D016679:Genome, Viral; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000276:immunology / Q000821:virology*; D010802:Phylogeny; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology*; D014625:Vaginal Neoplasms / Q000276:immunology / Q000821:virology
D004279:DNA, Viral