Iontophoresis of indocyanine green and monastral blue B for gonioscopic diode laser sclerectomy.
Ab interno gonioscopic diode laser sclerectomy should allow the creation of a filtration fistula in glaucoma treatment using light energy in the near infrared range. Diode laser sclerectomy can be facilitated by dying the sclera to optimize laser energy absorption at the appropriate wavelength. Indo-cyanine green (ICG) and Monastral Blue B (MBB) are two dyes that have their peak absorptions in the near infrared region. This study determined the feasibility of ICG and MBB iontophoresis in human cadaver sclera and transconjunctivally in rabbits in vivo. MBB was unable to achieve full-thickness scleral staining in either model. ICG was able to penetrate 400 microns in human cadaver sclera and approximately 500 microns transconjunctivally in rabbit sclera in vivo.
Wang
Y
Y
New England Eye Center, Tufts University School of Medicine, Boston, MA, USA.
Cohen
R E
RE
Schuman
J S
JS
D000818:Animals; D000869:Anterior Eye Segment; D004396:Coloring Agents; D006068:Gonioscopy; D006801:Humans; D007208:Indocyanine Green; D007211:Indoles; D007478:Iontophoresis / Q000379:methods*; D053685:Laser Therapy / Q000379:methods*; D009942:Organometallic Compounds; D011817:Rabbits; D012590:Sclera / Q000473:pathology; D012599:Sclerostomy / Q000379:methods*
D004396:Coloring Agents; D007211:Indoles; D009942:Organometallic Compounds; C015445:copper phthalocyanine; D007208:Indocyanine Green