title: Tumour necrosis factor-alpha gene expression by alveolar macrophages in human lung allograft recipient with recurrence of sarcoidosis. Toulouse Lung Transplantation Group.
abstract: Recurrence of sarcoidosis in lung allografts is an interesting model to study the pathogenesis of this disease. We report a case of sarcoidosis recurrence in a single lung allograft recipient 2 years after transplantation. The expression of tumour necrosis factor-alpha (TNF-alpha) gene by alveolar macrophages was monitored. The TNF-alpha gene was not expressed at the time of recurrence of sarcoidosis, but only later when prominent granulomas were observed.
authors.affiliation: Service de Pneumologie et Allergologie et INSERM CIF 91-07, CHU Rangueil, Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Martel
authors.forename: P C
authors.initials: PC
authors.lastname: Carré
authors.forename: G
authors.initials: G
authors.lastname: Carrera
authors.forename: B
authors.initials: B
authors.lastname: Pipy
authors.forename: P J
authors.initials: PJ
authors.lastname: Léophonte
mesh_terms: D000328:Adult; D015870:Gene Expression; D006084:Graft Rejection; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D012008:Recurrence; D012507:Sarcoidosis / Q000276:immunology* / Q000503:physiopathology / Q000601:surgery*; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D014409:Tumor Necrosis Factor-alpha