A new compound (AZ36041) promotes the survival of the neurons and reduces neurotoxicity of Alzheimer's beta-amyloid protein.
Alzheimer's beta-amyloid protein (A beta) is the main component of senile plaques, which are characteristic hallmarks of the Alzheimer's disease brain. Recently, there have been several reports that A beta has toxic effects on both cultured neurons and in the brain. We confirmed the neurotoxicity of A beta in vitro and found a new compound, called AZ36041 (4-chloro-N-(5-nitro-2-tiazoyl)benzenesulfone amide), which dramatically reduced A beta neurotoxicity. This compound was also found to have a neuroprotective effect against toxicity of glutamate and enhanced neuronal survival in the absence of neurotoxic compounds. AZ36041 may be a useful tool for investigating the mechanism of A beta neurotoxicity in vitro and in vivo.
Hasegawa
Y
Y
Institute for Life Science, Asahi Chemical Industry Co., Ltd., Shizuoka, Japan.
Sugimoto
E
E
Endo
T
T
Ogawa
K
K
Aratake
H
H
Morikawa
A
A
Kitaguchi
N
N
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects*; D005576:Colforsin / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013449:Sulfonamides / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
C098823:4-chloro-N-(5-nitro-2-thiazoyl)benezenesulfonamide; D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D013449:Sulfonamides; D013844:Thiazoles; D005576:Colforsin; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate