title: Inflammation of the brain after ischemia.
abstract: Cytokines which promote emigration of leukocytes from the vascular lumen into the injured brain tissue are produced at the site of incipient cerebral infarction. The blood-borne invaders then accelerate the decomposition of brain cells by their toxic by-products, phagocytic action, and by the immune reaction. Recently accumulated data in our laboratories and other research facilities show that depleting the amount of circulating leukocytes or administering anti-inflammatory chemicals such as cytokine blocking agents, anti-adhesion molecule antibodies, and immunosuppressants effectively minimize the size of ischemia induced cerebral infarction. Based on the fact the leukocyte invasion of the affected brain tissue occurs 6 to 24 hours after onset of ischemia, administration of an anti-inflammatory therapy may widen the therapeutic window against stroke.
authors.affiliation: Department of Pharmacology, Tokyo Medical College, Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kogure
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Onodera
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology; D001925:Brain Damage, Chronic / Q000276:immunology* / Q000473:pathology; D002545:Brain Ischemia / Q000276:immunology* / Q000473:pathology; D002544:Cerebral Infarction / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007962:Leukocytes / Q000276:immunology; D009336:Necrosis; D015427:Reperfusion Injury / Q000276:immunology / Q000473:pathology
chemical_list: D016207:Cytokines; D006360:Heat-Shock Proteins; D018836:Inflammation Mediators