title: In vitro and in vivo therapeutic activity of Parthenium hysterophorus against Trypanosoma evansi.
abstract: Crude 50% ethanolic extract of P. hysterophorus flowers exhibited trypanocidal activity in vitro at all the four concentrations tested i.e. 5, 50, 500 and 1000 micrograms/ml. In vivo trial revealed that the extract exerted antitrypanosomal effect at doses of 100 and 300 mg/kg body wt, i.p. as evidenced by significantly reduced (P < 0.01) mean parasitaemia on days 3, 4, 5 and 6 when compared with untreated control group. Further at 100 and 300 mg/kg, body wt doses, the survival period was significantly (P < 0.05) prolonged as compared to control group. The extract was, however, found toxic to the animals at 1000 mg/kg dose.
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India.
authors.forename: T S
authors.initials: TS
authors.lastname: Talakal
authors.forename: S K
authors.initials: SK
authors.lastname: Dwivedi
authors.forename: S R
authors.initials: SR
authors.lastname: Sharma
mesh_terms: D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*; D014352:Trypanosomiasis / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents