Role of lipid peroxidation in iron-induced cellular calcium overload.
Calcium overload is the common pathway leading to cell injury. The role of iron-induced lipid peroxidation in the modification of Ehrlich carcinoma cells calcium homeostasis has been studied. There is a lack of correlation between that modification and the value of lipid peroxidation. The stability characteristics of low-mol-weight iron complexes affect lipid peroxidation and, to a lesser extent, cellular calcium uptake. Lipid peroxidation appears not as a triggering factor of cellular calcium homeostasis modification, but as a concomitant phenomenon.
Anghileri
L J
LJ
Biophysics Laboratory, Medicine Faculty, University of Nancy, France.
Maincent
P
P
Thouvenot
P
P
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D005290:Ferric Compounds / Q000633:toxicity*; D006706:Homeostasis / Q000187:drug effects; D007773:Lactates / Q000633:toxicity; D019344:Lactic Acid; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*
D005290:Ferric Compounds; D007773:Lactates; D019344:Lactic Acid; D000255:Adenosine Triphosphate; D002118:Calcium