Modifications induced by -10 degrees Trendelenburg's posture in sodium tubular handling in patients with essential hypertension.
In essential hypertensive patients "exaggerated natriuresis" is a response to acute volume expansion. However, the underlying mechanisms for this remain to be determined. We studied 19 patients with essential hypertension (HP) and 9 normotensive subjects (NS). In all examined subjects the response to acute central volume expansion, without the plasma compositional change that Trendelenburg's position involves, was evaluated during 90 min (period T) after a similar period of deambulation (period D). Mean blood pressure (MBP), tubular sodium handling by the lithium clearance technique, plasma renin activity (PRA), plasma aldosterone (PA), plasma catecholamines and urine prostaglandine E2 and kallikrein were assessed after D and T. MBP was significantly higher in HP than in NS (p = 0.00001). HP showed "exaggerated natriuresis" after T (fractional excretion of sodium increased from 0.55 +/- 0.1% after D to 1.20 +/- 0.2% after T, p < 0.01). This was because of a decrease in their proximal fractional reabsorption of sodium (from 74.96 +/- 1.8% after D to 62.50 +/- 2.8% after T, p < 0.01). Plasma epinephrine and plasma dopamine after T were significantly lower than in standing position in HP (p < 0.01) but no in NS. The decrease in plasma renin activity after T in HP was 53%, and 32% in NS. There were not any significant differences between groups in the other neurohormonal systems studied. We conclude that the major determinant of "exaggerated natriuresis" in hypertensive patients is a higher stimulation of the cardiopulmonary receptors following Trendelenburg's position and consequently stronger reflex inhibition of sympathetic system activity and renin-angiotensin II activity. The "exaggerated natriuresis" after Trendelenburg's position in HP was an expression of abnormal pressure natriuresis.
Pamies Andreu
E
E
Hypertension and Lipids study group, Virgen del Rocio University Hospital, Sevilla, Spain.
Martin-Sanz
V
V
Muñiz-Grijalvo
O
O
Stiefel
P
P
Miranda
M L
ML
Villar
J
J
Molina
J
J
Garcia-Donas
M A
MA
Carneado de la Fuente
J
J
D000328:Adult; D000450:Aldosterone / Q000097:blood; D015992:Body Mass Index; D015232:Dinoprostone / Q000652:urine; D004837:Epinephrine / Q000097:blood; D005260:Female; D018475:Head-Down Tilt; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007610:Kallikreins / Q000652:urine; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D016683:Supine Position
D000450:Aldosterone; D012964:Sodium; D007610:Kallikreins; D012083:Renin; D015232:Dinoprostone; D009638:Norepinephrine; D004837:Epinephrine