title: Segregation and linkage analysis of the complex trait Q1.
abstract: Segregation and linkage analysis of GAW9 Problem 2 quantitative trait 1 (Q1) was performed. Eight segregation models comprising all possible combinations of the environmental factor (EF), quantitative trait 2 (Q2), and quantitative trait 3 (Q3) as covariates were considered. Seven of the eight segregation models showed strong evidence for a major gene, the other model was marginal. When all genotypes are known, some evidence for linkage (lod > 2) was found to all three of the markers that affect Q1. Furthermore, four of the eight models each showed some linkage (lod > 2) to two of the three markers that affect Q1 with no false positives. Each of these segregation analysis major genes is a hybrid combination of the true multiple loci that affect Q1.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Atwood
authors.forename: B D
authors.initials: BD
authors.lastname: Mitchell
authors.forename: N C
authors.initials: NC
authors.lastname: Stowell
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic