title: Improved estimation of tissue hydration and bound water fraction in rat liver tissue.
abstract: Based on recent improvements in the field, biexponential data from fresh rat liver and monoexponential data from cold storage experiments allow quantification of three distinct relaxation components in liver tissue: bound water (4.2%, R1 = 12.0 +/- 1.7 s-1, R2 = 440 +/- 180 s-1); structured water (59%, R1 approximately 3.3 +/- 0.07 s-1, R2 approximately 24.9 +/- 1.1 s-1); and free water (approximately 37%, R1 = R2 approximately 0.4 s-1). However, only the relaxation rates of the structured water component change with water content: R1A (s-1) = 6.53* Ms/Mw - 0.77 (r2 = 0.911); R2A (s-1) = 71.15 * Ms/Mw - 3.09 (r2 = 0.956), respectively. This suggests a slow exchange between bound and structured water in liver cells.
authors.affiliation: Institute of Medical Physics, University of Vienna, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Moser
authors.forename: P
authors.initials: P
authors.lastname: Holzmueller
authors.forename: M
authors.initials: M
authors.lastname: Krssak
mesh_terms: D000818:Animals; D015925:Cryopreservation / Q000379:methods*; D008099:Liver / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009926:Organ Preservation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water