title: Dose uniformity in MECS interstitial hyperthermia: the impact of longitudinal control in model anatomies.
abstract: The quality of temperature distributions that can be generated with the multi-electrode current source (MECS) interstitial hyperthermia system, which allows 3D control of the spatial SAR distribution, has been investigated. For the investigations, computer models of idealized anatomies were used. These anatomical models did not contain discrete vessels. Binary-media anatomies, containing media interfaces oriented parallel, perpendicular or oblique with respect to the long axis of the implant, represent simple anatomies which can be encountered in the clinic. The implant volume was about 40 cm3. A seven-catheter hexagonal implant geometry with a nearest-neighbor distance of 15 mm was used. In each interstitial probe between one and four electrodes with a diameter of 2.1 mm were placed along an "active section' with a length of 50 mm. The electrode segments had lengths of 50, 20, 12 and 9 mm. This study shows that even with high contrasts in electrical and thermal conductivity in the implant it remains possible to obtain satisfactory temperature distributions with the MECS system. Due to its 3D spatial control the temperature homogeneity in the implant can be made quite satisfactory, with T10-T90 of the order of 2-3 K. Treatment planning must ensure that the placement of the current source electrodes is compatible with the media configuration.
authors.affiliation: Department of Radiotherapy, University Hospital Utrecht, The Netherlands.
authors.forename: J F
authors.initials: JF
authors.lastname: van der Koijk
authors.forename: J
authors.initials: J
authors.lastname: Crezee
authors.forename: G M
authors.initials: GM
authors.lastname: van Leeuwen
authors.forename: J J
authors.initials: JJ
authors.lastname: Battermann
authors.forename: J J
authors.initials: JJ
authors.lastname: Lagendijk
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004566:Electrodes; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D008953:Models, Anatomic; D009369:Neoplasms / Q000628:therapy; D011786:Quality Control; D013696:Temperature