Constituents of Ardisia japonica and their in vitro anti-HIV activity.
As part of our screening of anti-AIDS agents from medicinal plants, the MeOH extract of the aerial parts of Ardisia japonica was tested, and it showed moderate in vitro anti-HIV activity. Reexamination to identify the compounds responsible for the anti-HIV activity revealed several known compounds and a new triterpenoid saponin (4) whose structure elucidation was accomplished by 1H-1H correlation spectroscopy (COSY, HOHAHA, ROESY) and 1H-13C heteronuclear correlation (HETCOR) NMR experiments. All of the isolated compounds were tested and, although none of the triterpenoid saponins was active, bergenin and norbergenin showed weak anti-HIV activity.
Piacente
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Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
Pizza
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De Tommasi
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Mahmood
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D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D006678:HIV / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000998:Antiviral Agents; D015699:HIV Envelope Protein gp120; D012503:Saponins; D014315:Triterpenes