[Increased plasma levels of endothelin in patints with essential arterial hypertension].
Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictive peptide. In this study the Authors measured in 25 subjects (15 with essential hypertension and 10 normal) plasma levels of endothelin-1. Patients with hypertension had significantly higher plasma ET-1 concentration than normal subjects (2.18 +/- 1.07 vs. 1.36 +/- 0.40 pg/ml, p < 0.02). Plasma arginine vasopressin, renin activity and aldosterone concentration did not show significant differences between hypertensive and normotensive subjects. These data suggest that ET-1 may be involved in the development or maintenance of hypertension.
Amoroso
A
A
Dipartimento di Medicina Clinica, Università degli Studi La Sapienza, Roma.
Cossu
M F
MF
Mariotti
A
A
Guido
F
F
Ferri
G M
GM
De Rosa
F G
FG
Sportelli
G
G
D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged
D016232:Endothelins
Incremento dei livelli plasmatici di endotelina in pazienti con ipertensione arteriosa essenziale.