[The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages].
Investigation made with the use of flow cytofluorimetry revealed that platelet-activating factor (PAF), the main mediator of inflammatory reaction, and a number of its analogs induced the expression of la antigen on the cell membrane of mouse peritoneal macrophages. The effects observed in the course of this investigation were dose-dependent. Moreover, the biological activity of the given class of substances was shown to depend on their chemical structure. Thus, PAF and its analogs exerted regulatory influence on an essential stage of the formation of immune response, which undoubtedly contributed to the activation of the immune system of the body during the development of inflammatory reaction.
Shebzukhov
Iu V
IuV
Tokisambaeva
S Zh
SZh
Mysiakin
E B
EB
Khaĭdukov
S V
SV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005434:Flow Cytometry; D000949:Histocompatibility Antigens Class II / Q000187:drug effects* / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000949:Histocompatibility Antigens Class II; D010972:Platelet Activating Factor
Vliianie faktora aktivatsii trombotsitov i ego sinteticheskikh analogov na ékspressiiu Ia-antigenov peritoneal'nymi makrofagami myshi.