Ultrastructure of Leydig cells in Down's syndrome.
Hormonal and ultrastructural examinations of the testis were performed in a patient with Down's syndrome. Plasma testosterone was abnormally low, and circulating levels of LH and FSH were higher than the normal range. The administration of HCG resulted in a low response of plasma testosterone. Electron microscopy revealed proliferation of smooth endoplasmic reticulum, an increase in paracrystalline inclusions and the absence of Reinke's crystals in Leydig cells.
Sasagawa
I
I
Department of Urology, Yamagata University, Japan.
Nakada
T
T
Kubota
Y
Y
Ishigooka
M
M
Hashimoto
T
T
Sawamura
T
T
Tateno
T
T
D000328:Adult; D004314:Down Syndrome / Q000473:pathology*; D006801:Humans; D007985:Leydig Cells / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron