Genetics of infectious disease resistance.
The identification of large numbers of candidates genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more successful route to human disease genes than extrapolation from mouse models of infection.
Hill
A V
AV
Wellcome Trust Centre for Human Genetics, University of Oxford, UK adrian.hill@timm.ax.ac.uk
D000818:Animals; D003141:Communicable Diseases / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*