title: [Lethal meningeal encephalitis from Cryptococcus neoformans var. neoformans in a girl without serious immunodeficiency].
abstract: Case report on a lethal meningo-encephalitis due to Cryptococcus neoformans in a 14-year-old girl without serious immunodeficiency inclusive HIV-infection. The detection of high quantities of cells of Cryptococcus neoformans (about 10,000/ml) and high levels of Cryptococcus antigen (up to 1:2048) in the cerebrospinal fluid are remarkable. The patient was treated with a triple combination of amphotericin B, flucytosine and fluconazole. After 18 days the cerebrospinal fluid was sterile. Nevertheless considerable lesions of the brain arised. The patient died from the Cryptococcus infection on day 74 of the antimycotic therapy. Cryptococcosis should be included into the differential diagnosis of the chronic lymphocytic pleocytosis of the cerebrospinal fluid connected with symptoms of intracranial pressure and ocular symptoms.
authors.affiliation: Klinik und Poliklinik für Kinderheilkunde, Universitätsklinikums Carl Gustay Carus, Technischen Universität Dresden, BR Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Wendisch
authors.forename: R
authors.initials: R
authors.lastname: Blaschke-Hellmessen
authors.forename: F
authors.initials: F
authors.lastname: Kaulen
authors.forename: R
authors.initials: R
authors.lastname: Schwarze
authors.forename: M
authors.initials: M
authors.lastname: Kabus
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000134:cerebrospinal fluid; D003453:Cryptococcosis / Q000175:diagnosis*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004660:Encephalitis; D017809:Fatal Outcome; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005437:Flucytosine / Q000627:therapeutic use; D018023:HIV Seronegativity; D006801:Humans; D007153:Immunologic Deficiency Syndromes
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine
vernacular_title: Tödliche Meningoenzephalitis durch Cryptococcus neoformans var. neoformans bei einem Mädchen ohne schwerwiegende Immundefekte.