[Contact photoallergic eczema caused by ketoprofen].
BACKGROUND
Since 1983, several cases of allergy and photoallergic contact dermatitis to ketoprofen gel have been reported in Italy and Spain. In France, this drug has been available for topic applications since 1989 and no cases of photoallergy have been reported.


METHODS
We observed two cases of photoallergic contact dermatitis to ketoprofen (Profenid gel, Ketum gel). Imputability was suggested by clinical history and proven by patch-tests showing evidence of crossed photoallergy with fenofibrate in both cases. Photoallergic dermatitis to oxybenzone was associated in one case.


CONCLUSIONS
Ketoprofen is the predominant nonsteroid anti-inflammatory drug responsible for allergic and/or photoallergic contact dermatitis resulting from topic applications. Its prevalence is probably underestimated in France in light of the number of cases reported in certain Mediterranean countries. Cross reactive photoallergy to ketoprofen and fenofibrate can be explained by the common benzoly-ketone structure of these compounds. In case of skin reaction, the other drug should not be prescribed and benzophenone-containing cosmetics discouraged.
Jeanmougin
M
M
Unité de Photodermatologie, Hôpital Saint-Louis, Paris.
Petit
A
A
Manciet
J R
JR
Sigal
M
M
Dubertret
L
L
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D004357:Drug Synergism; D005260:Female; D011345:Fenofibrate / Q000009:adverse effects; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012882:Skin Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen; D011345:Fenofibrate
Eczéma photo-allergique de contact au kétoprofène.