title: Benzodiazepine withdrawal syndrome seizures.
abstract: In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines. Both abrupt cessation of benzodiazepine intake and high-dose use seem to be critical for the appearance of seizures. Pharmacological features, such as short elimination half-life and high potency, might explain the higher risk of seizures observed in these patients.
authors.affiliation: Department of Psychiatry, Autonomous University of Madrid, Spain.
authors.forename: H
authors.initials: H
authors.lastname: Martínez-Cano
authors.forename: A
authors.initials: A
authors.lastname: Vela-Bueno
authors.forename: M
authors.initials: M
authors.lastname: de Iceta
authors.forename: R
authors.initials: R
authors.lastname: Pomalima
authors.forename: I
authors.initials: I
authors.lastname: Martínez-Gras
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D005260:Female; D005445:Flunitrazepam / Q000009:adverse effects; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D008140:Lorazepam / Q000009:adverse effects; D008297:Male; D002189:Marijuana Abuse / Q000150:complications; D008875:Middle Aged; D012306:Risk; D012640:Seizures / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D019966:Substance-Related Disorders / Q000503:physiopathology* / Q000523:psychology; D014229:Triazolam / Q000009:adverse effects
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D014229:Triazolam; D005445:Flunitrazepam; D008140:Lorazepam