title: Interleukin-1 beta facilitates afferent sensory transmission in the primary somatosensory cortex of anesthetized rats.
abstract: The effect of topical application of human recombinant interleukin-1 beta (IL-1) on afferent sensory transmission to the neurones in the primary somatosensory (SI) cortex was determined in anesthetized rats. Quantitative determination of the effect of IL-1 was made by generating post-stimulus time histograms of unit responses to the stimulation of receptive field. IL-1 (0.01, 0.1, 1.0 U) significantly facilitated afferent sensory transmission in SI cortical neurones (n = 22). IL-1-induced facilitation fully recovered by 60 min after drug. In control experiments (n = 10), saline solution containing 0.2 bovine serum albumin, used as a vehicle, did not affect afferent sensory transmission. Our results suggest that IL-1 may be involved in the processing of afferent sensory information in the SI cortex of rats.
authors.affiliation: Department of Physiology, Hallym University, Chunchon, Kangwon-do, South Korea.
authors.forename: C
authors.initials: C
authors.lastname: Won
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
authors.forename: H C
authors.initials: HC
authors.lastname: Shin
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007375:Interleukin-1 / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D007375:Interleukin-1