title: Analysis of associations between major histocompatibility complex (BoLA) class I haplotypes and subclinical mastitis of dairy cows.
abstract: The associations between BoLA class I haplotypes and subclinical mastitis were investigated using information on 333 cows from three different breeds and crossbreeds from 14 dairy herds in Denmark. Somatic cell count and bacteriological status were used as markers for subclinical mastitis. Associations between BoLA class I haplotypes and IMI status were also determined. The association between BoLA class I haplotypes and subclinical mastitis was weak. The A10(W50), A11, A12(A30), A16, A19(A6), A21, A26, and A31(A30) alleles were associated with different markers of subclinical mastitis. Susceptibility or resistance to the two bacteria categories was associated with different alleles. This study indicated that BoLA antigens may be involved in resistance to mastitis and that resistance may be specific for a particular pathogen.
authors.affiliation: Danish Veterinary Laboratory, Copenhagen, Denmark.
authors.forename: F M
authors.initials: FM
authors.lastname: Aarestrup
authors.forename: N E
authors.initials: NE
authors.lastname: Jensen
authors.forename: H
authors.initials: H
authors.lastname: Ostergård
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle; D002452:Cell Count; D005260:Female; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D007113:Immunity, Innate / Q000276:immunology; D007774:Lactation; D008414:Mastitis, Bovine / Q000276:immunology* / Q000382:microbiology; D008892:Milk / Q000166:cytology; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D015395:Histocompatibility Antigens Class I