title: HSP100/Clp proteins: a common mechanism explains diverse functions.
abstract: The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription. HSP100/Clp proteins are also synthesized in a variety of specific patterns and, in eukaryotes, are localized to different subcellular compartments. Recent data suggest that a common ability to disassemble higher-order protein structures and aggregates unifies the molecular functions of this diverse family.
authors.affiliation: Howard Hughes Medical Institute, Chicago, IL, USA.
authors.forename: E C
authors.initials: EC
authors.lastname: Schirmer
authors.forename: J R
authors.initials: JR
authors.lastname: Glover
authors.forename: M A
authors.initials: MA
authors.lastname: Singer
authors.forename: S
authors.initials: S
authors.lastname: Lindquist
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000378:metabolism / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D010583:Bacteriophage mu / Q000502:physiology; D049071:Endopeptidase Clp; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000145:classification* / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015800:Protozoan Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D012697:Serine Endopeptidases / Q000502:physiology; D013312:Stress, Physiological
chemical_list: D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D015800:Protozoan Proteins; D029701:Saccharomyces cerevisiae Proteins; C070972:HsP104 protein, S cerevisiae; D012697:Serine Endopeptidases; D049071:Endopeptidase Clp; D000251:Adenosine Triphosphatases; C095049:ClpB protein, Leishmania; C088072:ClpX protein, E coli; D000074183:ATPases Associated with Diverse Cellular Activities