title: [Acute Chagas cardiopathy. A systematic study of the intracardiac excitatory-conduction and autonomic nervous systems in an autochthonous case in Acre].
abstract: The histopathology of the heart is described in an acute case of Chagas' disease (DC). Lesions involving the conducting system (SC) and the autonomic intracardiac nervous system (SNAIC) are emphasized. Light microscopy showed acute pan-carditis with plenty of Trypanosoma cruzi amastigotes within heart muscle cells. Multiple inflammatory foci were found in the SC with parasitic nests within the atrioventricular node and left his bundle. There were also severe atrial periganglionitis and perineuritis with or without peripheral involvement of those structures. Apparently there was no cardiac neuronal depopulation. The epidemiological study suggested transmission through Rhodnius pictipes. To the best of our knowledge, this is the first reported case of acute DC from the Amazonian basin with systematized microscopy study of the SC and SNAIC.
authors.affiliation: Centro de Ciências Biomédicas, Universidade Federal de Uberlândia, MG.
authors.forename: A
authors.initials: A
authors.lastname: Rocha
authors.forename: S A
authors.initials: SA
authors.lastname: Neves
authors.forename: E R
authors.initials: ER
authors.lastname: Lopes
authors.forename: V de O
authors.initials: Vde O
authors.lastname: Macêdo
mesh_terms: D000208:Acute Disease; D000818:Animals; D001341:Autonomic Nervous System / Q000469:parasitology / Q000473:pathology*; D001938:Brazil; D002598:Chagas Cardiomyopathy / Q000469:parasitology / Q000473:pathology*; D002675:Child, Preschool; D017809:Fatal Outcome; D006321:Heart / Q000294:innervation* / Q000469:parasitology; D006329:Heart Conduction System / Q000469:parasitology / Q000473:pathology*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D014349:Trypanosoma cruzi / Q000302:isolation & purification
vernacular_title: Contribuição ao conhecimento da cardiopatia chagásica aguda. Estudo sistematizado dos sistemas excito-condutor e nervoso autônomo intracardíaco em caso autóctone do Acre.