[Effect of pharmacotherapy of affective disorders on the psycho-semantics of alcoholic patients].
90 alcoholic patients (II stage of alcoholism) with secondary affective disorders (anxiety, depression) were divided into 4 groups. The patients of the first group received the GABA receptor ligand baclofen during 3 weeks. Sybazon preparation was used in the second group, while the patients of the third group were treated with amitriptyline. Placebo was applied in the forth group. The clinical psychological tests demonstrated that all drugs caused quite effective relief of affective disorders. Psychosemantic tests application showed that the pharmacotherapy caused positive changes in patients of 1-3 groups. These changes touched on both system of personal estimations and relations of personality to himself and to the world around i.e. psychosemantic sphere. Such changes in psychosemantic sphere were not observed in the 4-th group of patients (placebo). Besides it was revealed that each drug caused some specific changes in psychosemantic sphere. The result obtained were supposed to have some theoretical value in comprehension of brain-psychics relations as well as the applied significance for adequate choice of affective disorders pharmacotherapy of alcoholic patients.
Krupitskiĭ
E M
EM
Burakov
A M
AM
Grinenko
A Ia
AIa
Borodkin
Iu S
IuS
D000437:Alcoholism / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D000639:Amitriptyline / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001418:Baclofen / Q000627:therapeutic use; D003119:Color Perception Tests; D003243:Consciousness / Q000187:drug effects*; D003975:Diazepam / Q000627:therapeutic use; D018755:GABA Agonists / Q000627:therapeutic use; D006801:Humans; D008950:MMPI; D019964:Mood Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology*; D012659:Semantic Differential; D012660:Semantics
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D018755:GABA Agonists; D000639:Amitriptyline; D001418:Baclofen; D003975:Diazepam
Vliianie farmakoterapii afferentnykh narusheniĭ u bol'nykh alkogolizmom na psikhosemantiku.