[Immunohistochemical study of 17 cases of rectal neuroendocrine tumors].
Seventeen rectal neuroendocrine tumors ("Rectal Carcinoids") were studied by immunohistochemistry using antibodies directed against neuroendocrine markers: chromogranin A, neuron-specific enolase, synaptophysin, neuroendocrine peptides (ACTH, glicentin, glucagon, pancreatic polypeptide, somatostatin, vasoactive intestinal peptide) and antibody against serotonin. All patients with tumors measuring 1 cm or less had no specific symptoms and survived between fifteen months and eight years. Only one patient with a 6 cm poorly differentiated neuroendocrine carcinoma died less than one year after diagnosis. Only five out of seventeen tumors secreted serotonin. Most tumors were derived from L cell secreting glucagon, glicentin or pancreatic polypeptide.
Chetritt
J
J
Service d'Anatomie Pathologique B, Hôpital G. et R. Laennec, Nantes.
Sagan
C
C
Heymann
M F
MF
Le Bodic
M F
MF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000737:chemistry* / Q000401:mortality; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism*; D011237:Predictive Value of Tests; D012004:Rectal Neoplasms / Q000737:chemistry* / Q000401:mortality; D015996:Survival Rate
Etude immunohistochimique de 17 cas de tumeurs neuro-endocrines rectales.