title: TDT with covariates and genomic screens with mod scores: their behavior on simulated data.
abstract: We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Rice
authors.forename: R J
authors.initials: RJ
authors.lastname: Neuman
authors.forename: S L
authors.initials: SL
authors.lastname: Hoshaw
authors.forename: E W
authors.initials: EW
authors.lastname: Daw
authors.forename: C
authors.initials: C
authors.lastname: Gu
mesh_terms: D003198:Computer Simulation; D005820:Genetic Testing / Q000379:methods*; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008957:Models, Genetic