Nonsterol related resistance in Ustilago maydis to the polyene antifungals, amphotericin B and nystatin.
Two amphotericin B resistant mutants of Ustilago maydis were isolated following direct selection from a wild-type population. Each mutant was demonstrated to be cross-resistant to nystatin yet remained sensitive to azoles. Sterol analysis indicated a sterol profile similar to the parent strain, precluding the involvement of an alteration in ergosterol biosynthesis as the cause of polyene resistance.
Joseph-Horne
T
T
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, U.K.
Manning
N
N
Holoman
D
D
Kelly
S
S
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005659:Fungicides, Industrial / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000494:pharmacology*; D013261:Sterols / Q000032:analysis; D014230:Triazoles / Q000494:pharmacology; D014588:Ustilago / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000935:Antifungal Agents; D005659:Fungicides, Industrial; D013261:Sterols; D014230:Triazoles; D009761:Nystatin; C032910:triadimefon; D000666:Amphotericin B