title: Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).
abstract: Amyloid beta protein (Abeta) deposition was investigated in the frontal cortex of 8 cases of (genetically confirmed) chromosome 14-linked Alzheimer's disease (AD) using the end-specific monoclonal antibodies BA27 and BC05 to detect the presence of Abeta40 and Abeta42(43), respectively. In all patients, Abeta42(43) was the predominant peptide species present. The total amount of Abeta40 and Abeta42(43) deposited was more than twice the amount deposited in cases of sporadic AD of similar disease duration, although the ratio between the extent of Abeta40 and Abeta42(43) deposition was unaltered, compared with sporadic AD. Therefore, (one of) the effects of the mutations in the presenilin 1:PS-1 (S182) gene may be to cause or at least promote an early and excessive deposition of Abeta42(43) within the brain, a property shared with other inherited forms of AD, such as those due to amyloid precursor protein mutations, and Down's syndrome (trisomy 21).
authors.affiliation: Department of Pathological Sciences, Division of Molecular Pathology, University of Manchester, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Mann
authors.forename: T
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: N J
authors.initials: NJ
authors.lastname: Cairns
authors.forename: P L
authors.initials: PL
authors.lastname: Lantos
authors.forename: D
authors.initials: D
authors.lastname: Nochlin
authors.forename: S M
authors.initials: SM
authors.lastname: Sumi
authors.forename: T D
authors.initials: TD
authors.lastname: Bird
authors.forename: P
authors.initials: P
authors.lastname: Poorkaj
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: M
authors.initials: M
authors.lastname: Hutton
authors.forename: G
authors.initials: G
authors.lastname: Prihar
authors.forename: R
authors.initials: R
authors.lastname: Crook
authors.forename: M N
authors.initials: MN
authors.lastname: Rossor
authors.forename: M
authors.initials: M
authors.lastname: Haltia
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000235:genetics / Q000648:ultrastructure; D016564:Amyloid beta-Protein Precursor / Q000032:analysis / Q000235:genetics; D000911:Antibodies, Monoclonal; D001057:Apolipoproteins E; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000737:chemistry / Q000473:pathology*; D017354:Point Mutation; D053764:Presenilin-1
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000911:Antibodies, Monoclonal; D001057:Apolipoproteins E; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1