Osteonectin gene expression in fibrotic liver.
Osteonectin is an extracellular matrix (ECM) protein which is secreted by various cell types, and regulates tissue remodeling and cell proliferation. In the present study, we have examined the expression of osteonectin in fibrotic liver. Osteonectin transcripts were undetectable in normal liver, however, the abundant expression of the osteonectin gene was detected in fibrotic liver. The transcripts of osteonectin were only detected in hepatic lipocytes and the number of lipocytes was increased in fibrotic liver. These results suggested that in fibrotic liver, enhanced osteonectin expression may play an important role in liver fibrosis.
Inagaki
H
H
Department of Chemistry, National Industrial Institute of Nagoya, Japan.
Lin
K H
KH
Maeda
S
S
Saito
T
T
D000818:Animals; D001483:Base Sequence; D015870:Gene Expression / Q000235:genetics*; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D015676:Osteonectin / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D015676:Osteonectin