Lipid composition of platelets in patients suffering from migraine without aura.
Patients with migraine have a platelet hyperaggregability. As this alteration could be the consequence of an abnormal lipid composition of platelet membranes, we studied the phospholipid specimens and the cholesterol/phospholipid ratio in platelet of neuron patients suffering from migraine. The cholesterol/phospholipid ratio was 0.7 +/- 0.1 (normal 0.6 +/- 0.1, molar ratio). The proportion of five main platelet phospholipids components including phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, phosphatidylserine, and phosphatidylinositol, were also normal. These data suggest that platelet hyperactivity in patients with migraine is not due to an altered lipid content of those cells.
Vecino
A M
AM
Department of Hematology, Hospital Ramon y Cajal, Madrid, Spain.
Alvarez-Cermeño
J C
JC
Jimenez-Huete
A
A
Navarro
J L
JL
Cesar
J M
JM
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000737:chemistry* / Q000648:ultrastructure; D002462:Cell Membrane / Q000737:chemistry; D002784:Cholesterol / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D010743:Phospholipids / Q000032:analysis; D010974:Platelet Aggregation
D008055:Lipids; D010743:Phospholipids; D002784:Cholesterol