[Deficiency of maternal recognition of fetal-placental antigens in pregnancy complicated by idiopathic growth retardation].
We employed the leucocyte-migration inhibition assay to assess reactivity of cells from post-partum women to self placental antigens (SPA) and the presence of the migration inhibition blocking factor in the sera of these women. We also used complement dependent microcytotoxicity assay according to Terasaki to detect anti-fetal lymphocyte cytotoxic antibodies (AFCA) in these sera. Our study was performed in the group of 13 mothers of hypotrophic children and in the group of 14 mothers of eutrophic children. In none of the cases of both groups were AFCA detected. Using the migration inhibition assay we concluded that the deficiency of the response to ASPA occurs significantly more often in the "hypotrophic" than in the "eutrophic" mothers. Our study suggests: 1. lack of the maternal recognition of the fetus (lack of migration inhibition, or lack of the blocking factors) as the potential cause of the intrauterine growth retardation, 2. intrauterine growth retardation is not connected with the presence of AFCA in maternal serum.
Dudarewicz
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L
Kliniki Perinatologii Instytutu Ginekologii i Połoznictwa Akademii Medycznej w Lodzi.
Kopala
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M
Kaczmarek
A
A
D017951:Antigen Presentation; D000961:Antilymphocyte Serum / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000276:immunology*; D005333:Fetus / Q000276:immunology*; D006801:Humans; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*
D000961:Antilymphocyte Serum
Zaburzenia odpowiedzi immunologicznej matki na antygeny płodowo-łozyskowe w ciazy powikłanej idiopatyczna hipotrofia.