title: Adenosine for refractory pulmonary hypertension.
abstract: We report 2 patients with refractory acute pulmonary hypertension. In both, a central venous infusion of adenosine into the circulation effectively lowered pulmonary arterial pressure when standard treatment measures had failed, and reversed the clinical state of shock by achieving pulmonary vasodilatation. We conclude that adenosine may help lower pulmonary arterial pressure without lowering systemic arterial pressure in the setting of acute pulmonary hypertension when standard measures have failed.
authors.affiliation: Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Fullerton
authors.forename: J
authors.initials: J
authors.lastname: Jaggers
authors.forename: S D
authors.initials: SD
authors.lastname: Jones
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
authors.forename: R C
authors.initials: RC
authors.lastname: McIntyre
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D000328:Adult; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine