Radioimmunoguided surgery and colorectal cancer.
Radioimmunoguided surgery is a technique that aims to delineate the extent of epithelial neoplasms (primary/recurrent) and their spread (local, regional, and distant) which are not adequately visualized by conventional imaging techniques. The target lesion binds radiolabelled, tumour-associated monoclonal antibodies which are administered in the days before surgery and which bind to the target lesion. The radiotracer is detected intraoperatively using a hand-held gamma detecting probe. This identifies the extent of the tumour, involvement of lymph nodes or other organs and may allow a more complete surgical clearance of the tumour. This article provides a basic understanding of the RIGS (radioimmunoguided surgery) technique, the monoclonal antibodies which are used and outlines the advantages and limitations of this technique.
Aftab
F
F
Department of General Surgical Oncology, European Institute of Oncology, Milan, Italy.
Stoldt
H S
HS
Testori
A
A
Imperatori
A
A
Chinol
M
M
Paganelli
G
G
Geraghty
J
J
D000911:Antibodies, Monoclonal; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D003107:Colorectal Surgery / Q000379:methods*; D006801:Humans; D007432:Intraoperative Period; D011379:Prognosis; D016719:Radioimmunodetection / Q000639:trends; D016019:Survival Analysis
D000911:Antibodies, Monoclonal