Lung clearance of aerosolized 99mTc erythromycin lactobionate in rabbits.
In order to assess the lung clearance of aerosolized 99mTc Erythromycin Lactobionate (EL), 99mTc EL was administered to 9 New Zealand rabbits by inhalation. 5 rabbits inhaled cigarette smoke before 99mTc EL. Clearance half times were 3.0 +/- 0.9 hours in normals, 5.5 +/- 1.0 hours after smoke exposure. Clearance was not affected after destroying the surfactant layer. Slower clearance after smoke exposure may be due to the inhibition of mucociliary clearance. 99mTc EL can be considered as an alternative radioaerosol for ventilation imaging.
Durak
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Dokuz Eylül University School of Medicine, Department of Nuclear Medicine, Izmir, Turkey. fekom@cakabey.ege.edu.tr
Ertay
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T
Sayit
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E
Aktoğu
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S
Kut
O
O
Güven
H
H
Güre
A
A
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011663:Pulmonary Surfactants / Q000502:physiology; D011817:Rabbits; D011877:Radionuclide Imaging; D012016:Reference Values; D012907:Smoking
D000336:Aerosols; D015609:Organotechnetium Compounds; D011663:Pulmonary Surfactants; C102272:technetium Tc 99m erthyromycin lactobionate; C077318:technetium Tc 99m erythromycin; D002245:Carbon Dioxide; D004917:Erythromycin; D010100:Oxygen