CD4 deficiency in myelodysplastic syndrome with monosomy 7.
We describe a patient with myelodysplastic syndrome with monosomy 7 presenting with a T-cell defect. He suffered from infections from the age of 10 years, when a CD4 deficiency and impaired lymphoproliferative responses in vitro were found. The only symptom of a myelodysplastic syndrome at that time was thrombocytopenia with giant platelets. Monosomy 7 was found in the bone marrow cells. At the age of 11 years he developed other characteristics of monosomy 7 including splenomegaly and anaemia. Some months later leukaemia was diagnosed.


CONCLUSIONS
In non-HIV CD4 deficiency myelodysplastic syndrome has to be considered.
Weemaes
C M
CM
Department of Paediatrics, University Hospital Nijmegen, Netherlands.
Preijers
F
F
de Vaan
G A
GA
Bakkeren
J A
JA
Klasen
I S
IS
Haraldsson
A
A
D015704:CD4 Antigens / Q000097:blood*; D002648:Child; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000276:immunology*
D015704:CD4 Antigens