title: Pruritus in Creutzfeldt-Jakob disease.
abstract: We report three patients with Creutzfeldt-Jakob disease, whose first symptom was severe pruritus, similar to that observed in scrapie. The pruritus was resistant to therapy. The underlying mechanisms are unclear, but we speculate that the pruritus may result from brainstem involvement.
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Shabtai
authors.forename: P
authors.initials: P
authors.lastname: Nisipeanu
authors.forename: J
authors.initials: J
authors.lastname: Chapman
authors.forename: A D
authors.initials: AD
authors.lastname: Korczyn
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011537:Pruritus / Q000209:etiology*