Roles of protein-tyrosine phosphatases in growth factor signalling.
Protein-tyrosine phosphatases (PTPs) as well as protein-tyrosine kinases play key roles in various growth factor-or cytokine-mediated signal transduction pathways. Some PTP directly dephosphorylates tyrosine-phosphorylated growth factor receptors, whereas others mediate upstream signals to the downstream pathway as a second messenger of growth factor stimulus. In addition, some PTP functions as a negative feed-back signal in the growth-factor signalling. Since PTPs appear to regulate growth factor-mediated cell proliferation in both a positive and negative manner, overexpression or loss of certain types of PTPs might contribute to malignant transformation of cells.
Matozaki
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Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Kasuga
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D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D017493:Leukocyte Common Antigens / Q000502:physiology; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D006133:Growth Substances; D047908:Intracellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D017493:Leukocyte Common Antigens; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases