The relationship between urine excretion and biogenic amines and their metabolites in cerebrospinal fluid of schizophrenic patients.
Concentrations of norepinephrine and metabolites of biogenic amines were measured in lumbar cerebrospinal fluid of 30 patients with chronic schizophrenia, nine of whom were polyuric. The mean level of norepinephrine was two-fold higher (p < or = 0.025) in polyuric patients than in patients whose excretion of urine was within the normal range. CSF levels of histamine's primary metabolite, tele-methylhistamine, an index of brain histaminergic activity, were positively correlated (p < 0.005) with daily urine volume. These results are consistent with the known influence of norepinephrine and histamine on fluid regulation and suggest that norepinephrine and histamine may be involved in psychogenic polydipsia-polyuria in schizophrenic patients.
Prell
G D
GD
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, NY 10029, USA.
Green
J P
JP
Elkashef
A M
AM
Khandelwal
J K
JK
Linnoila
M
M
Wyatt
R J
RJ
Lawson
W B
WB
Jaeger
A C
AC
Kaufmann
C A
CA
Kirch
D G
DG
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid; D000328:Adult; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D002908:Chronic Disease; D004326:Drinking / Q000502:physiology; D005260:Female; D006632:Histamine / Q000134:cerebrospinal fluid; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008761:Methylhistamines / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid*; D011141:Polyuria / Q000503:physiopathology*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
D001679:Biogenic Amines; D008761:Methylhistamines; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006632:Histamine; C020404:tele-methylhistamine; D009638:Norepinephrine; D006719:Homovanillic Acid