title: Clinical evaluation of antineutrophil cytoplasmic autoantibodies in ANCA-associated diseases.
abstract: Antineutrophil cytoplasmic autoantibodies have been performed in 110 patients referred to the laboratory as a presumptive systemic vasculitis, idiopathic crescentic glomerulonephritis, inflammatory bowel disease or SLE with vascular manifestation. 25 patients were found to be positive with c-, or p-ANCA patterns in indirect immunofluorescent test. We describe several cases in which histological confirmation is not available, an early consideration of a positive ANCA test may offer a reliable diagnosis and effective therapeutic handling, while the cases when the test was not considered, the occurence of relapse was inevitable.
authors.affiliation: Medical Clinic Nr. 1, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Cristea
authors.forename: T
authors.initials: T
authors.lastname: Badea
authors.forename: G
authors.initials: G
authors.lastname: Bodizs
authors.forename: N
authors.initials: N
authors.lastname: Olinic
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015267:Churg-Strauss Syndrome / Q000175:diagnosis; D003092:Colitis / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis; D005921:Glomerulonephritis / Q000175:diagnosis*; D006801:Humans; D007158:Immunologic Techniques; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000097:blood*; D014657:Vasculitis / Q000175:diagnosis*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D012697:Serine Endopeptidases; D053146:Myeloblastin