[Post-partum dysthyroidism. Prospective study in a French region (1986-1988)].
Post-partum thyroiditis' prevalence has not been previously evaluated in France.


OBJECTIVE
To study prospectively a cohort of delivered women to evaluate the prevalence of antimicrosomal antibodies and dysthyroidism during the post partum period. DESIGN, PATIENTS AND MEASURES: 400 women were observed 4 to 12 weeks after delivery and evaluated for the presence of a goiter and a measure of antimicrosomal antibodies (AMA) and us TSH. A subgroup of these selected women was then prospectively followed. HLA typing was also performed.


RESULTS
4 to 12 weeks after delivery, a goiter was found in 40 women. 19 women had positive AMA levels. No abnormality in thyroid function was detected during this period. In these selected women, 8 cases of dysthyroidism, mainly hypothyroidism, were diagnosed later on, 3 to 9 months after delivery. One of them became AMA positive during the follow-up, so the AMA prevalence was 5%. HLA DR4 and the hyplo-type HLA A3B7 were more frequent in this selected population.


CONCLUSIONS
Post-partum thyroiditis is a rare and benign disease in France. The transient dysthyroidism occurs later than 3 months after delivery, mainly in women with positive AMA (5% of the parturients). HLA DR4 is more often encountered in this thyroid pathology, as already observed in other Caucasian populations.
Mesrine
S
S
Service de Médecine B, CHU Bretonneau, Tours.
Lécomte
P
P
Royère
D
D
Besnard
J C
JC
Berger
C
C
D000906:Antibodies / Q000097:blood; D015982:Bias; D005260:Female; D005602:France / Q000453:epidemiology; D006042:Goiter / Q000453:epidemiology / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology* / Q000276:immunology; D007037:Hypothyroidism / Q000453:epidemiology* / Q000276:immunology; D008861:Microsomes / Q000276:immunology; D011247:Pregnancy; D011446:Prospective Studies; D011644:Puerperal Disorders / Q000453:epidemiology* / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology
D000906:Antibodies; D013954:Thyroglobulin
Dysthyroïdies du post-partum. Etude prospective dans une région française (1986-1988).