Strong association of the third hypervariable region of HLA-DR beta 1 with autism.
We reported that the major histocompatibility complex (MHC) including the null allele of the C4B gene and the extended haplotype B44-C30-DR4 is associated with autism. We report now that the third hypervariable region (HVR-3) of certain DR beta 1 alleles have very strong association with autism. The HVR-3 of DR beta 1* 0401 or the shared HVR-3 alleles DR beta 1* 0404 and DR beta 1* 0404 and DR *0101, was expressed on extended haplotypes in 23 of 50 (46%) autistic subjects as compared to only 6 of 79 (7.5%) normal subjects. Another HVR-3 sequence, the DR beta 1* 0701 allele, was carried on extended haplotypes in 16 (32.0%) of the autistic subjects as compared to 8 (10.1%) of the normal subjects.
Warren
R P
RP
Center for Persons with Disabilities, Utah State University, Logan 84322, USA. medlab@cc.usu.edu
Odell
J D
JD
Warren
W L
WL
Burger
R A
RA
Maciulis
A
A
Daniels
W W
WW
Torres
A R
AR
D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics* / Q000276:immunology*; D002875:Chromosomes / Q000276:immunology; D005260:Female; D015798:HLA-DR1 Antigen / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics / Q000276:immunology*; D008297:Male
D015798:HLA-DR1 Antigen; D007135:Immunoglobulin Variable Region