A new biological approach to vital pulp therapy.
Molecular biology is providing opportunities to develop new strategies or agents for the treatment of a wide variety of diseases. The availability of large amounts of highly purified proteins produced by recombinant DNA techniques is an obvious example. Recent evidence has implicated proteins belonging to the bone morphogenetic protein (BMP) subgroup of the transforming growth factor beta supergene family in tooth formation and dentinogenesis. It has long been known that bone and dentin contain bone morphogenetic protein activity. Recently, recombinant human BMP-2, -4, and -7 (also known as OP-1), have been shown to induce reparative dentin formation in experimental models of large direct pulp exposures in permanent teeth. The manner in which these agents act appears unique. New reparative dentin replaces the stimulating agents applied directly to the partially amputated pulp. Hence, the new tissue forms contiguous with, largely superficial to, and not at the expense of the remaining vital pulp tissue. This suggests a therapeutic approach permitting the induction of a predetermined and controlled amount of reparative dentin. Additionally, OP-1 has been associated with the formation of reparative dentin after application to a freshly cut but intact layer of dentin. These findings may provide future clinicians with additional options for the treatment of substantially damaged or diseased vital teeth.
Rutherford
B
B
University of Michigan School of Dentistry, Ann Arbor 48109-1078, USA.
Fitzgerald
M
M
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D003782:Dental Pulp / Q000033:anatomy & histology / Q000187:drug effects; D003788:Dental Pulp Diseases / Q000188:drug therapy*; D003804:Dentin / Q000033:anatomy & histology / Q000187:drug effects; D003809:Dentin, Secondary / Q000033:anatomy & histology / Q000139:chemically induced; D003810:Dentinogenesis / Q000235:genetics; D006133:Growth Substances / Q000235:genetics / Q000627:therapeutic use; D006801:Humans; D008967:Molecular Biology; D009805:Odontogenesis / Q000235:genetics; D011506:Proteins / Q000235:genetics / Q000627:therapeutic use; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000627:therapeutic use
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta