title: Evaluation of urine gamma-glutamyl transpeptidase-to-creatinine ratio as a diagnostic tool in an experimental model of aminoglycoside-induced acute renal failure in the dog.
abstract: The potential diagnostic utility of the urine gamma-glutamyl transpeptidase (GGT)-to-creatinine ratio was evaluated in an experimental canine model of aminoglycoside-induced nephrotoxicity. A therapeutic dosage of gentamicin resulted in a twofold increase in the mean urine GGT-to-creatinine ratio that was not associated with clinically significant nephrotoxicity. In dogs each given a nephrotoxic dosage of gentamicin, an increase in mean urine GGT-to-creatinine ratios approximately three times baseline values preceded clinically significant abnormalities in serum creatinine, urine specific gravity, and urine protein-to-creatinine ratio. The urine GGT-to-creatinine ratio appears superior as an early indicator of aminoglycoside-induced nephrotoxicity. Further studies in canine clinical cases are warranted.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Rivers
authors.forename: P A
authors.initials: PA
authors.lastname: Walter
authors.forename: T D
authors.initials: TD
authors.lastname: O'Brien
authors.forename: V L
authors.initials: VL
authors.lastname: King
authors.forename: D J
authors.initials: DJ
authors.lastname: Polzin
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000652:urine / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D003404:Creatinine / Q000097:blood / Q000652:urine*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000652:urine*; D004285:Dogs; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000494:pharmacology; D011507:Proteinuria / Q000652:urine / Q000662:veterinary; D013046:Specific Gravity; D005723:gamma-Glutamyltransferase / Q000652:urine*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D003404:Creatinine; D005723:gamma-Glutamyltransferase