title: Linkage maps of rat chromosomes 15, 16, 17, 19, and X.
abstract: Linkage maps of rat chromosomes 15, 16, 17, 19, and X were constructed by multipoint genetic linkage analysis of 22 polymorphic markers in 40 F2 progeny of Fischer (F344/N) and Lewis (LEW/N) inbred rat strains. These markers are associated with eight genes (angiotensin receptor A, M3 muscarinic acetylcholine receptor, heme oxygenase, endothelin receptor A, haptoglobin, tyrosine aminotransferase, phosphoribosylpyrophosphate synthetase subunit II, and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) and 14 anonymous loci. Linkage analysis placed the markers into five linkage groups covering 11.7,7.9,11.6,42.5, and 5.1cM. These linkage groups were assigned to rat chromosomes 15, 16, 17, 19, and X, respectively, either by mouse x rat somatic cell hybrid analysis or based on previously identified locations of severalloci. In polymorphism analysis, these markers exhibited two to nine different alleles in 16 inbred rat strains.
authors.affiliation: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Du
authors.forename: E F
authors.initials: EF
authors.lastname: Remmers
authors.forename: E A
authors.initials: EA
authors.lastname: Goldmuntz
authors.forename: H
authors.initials: H
authors.lastname: Zha
authors.forename: P
authors.initials: P
authors.lastname: Mathern
authors.forename: Y P
authors.initials: YP
authors.lastname: Ding
authors.forename: S
authors.initials: S
authors.lastname: Kotake
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: R L
authors.initials: RL
authors.lastname: Wilder
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D051381:Rats / Q000235:genetics*; D011919:Rats, Inbred Strains
chemical_list: D017931:DNA Primers; D005819:Genetic Markers