Inhibitors of thymine nucleotide biosynthesis: antimetabolites that provoke genetic change via primary non-DNA targets.
Folate antagonists and direct-acting inhibitors of thymidylate synthase are potent genotoxic antimetabolites. These agents induce genetic change not by attacking DNA, but by interfering with the control of DNA precursor metabolism. This review surveys the genetic effects attributable to selected representatives of this class of antimetabolites.
Kunz
B A
BA
School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, Australia. bkunz@deakin.edu.au
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity; D005493:Folic Acid Antagonists / Q000633:toxicity*; D006801:Humans; D009153:Mutagens / Q000633:toxicity*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D013942:Thymine Nucleotides / Q000096:biosynthesis
D000964:Antimetabolites, Antineoplastic; D002273:Carcinogens; D005493:Folic Acid Antagonists; D009153:Mutagens; D013942:Thymine Nucleotides; D013940:Thymidylate Synthase; C024157:thymidine 5'-triphosphate