title: Immunostimulating properties of the complexes of inosine derivatives.
abstract: The effects of the complexes of inosine (Ino) analogues of isoprinosine on the immune response to sheep red blood cells (SRBC), in plaque-forming cells assay (PFC), in mice spleen, and on the Fc-dependent SRBC phagocytosis in mice peritoneal macrophages were investigated. Molar ratios of 1:3 of the complexes of inosine with N,N-dimethylaminopropanol-2-p-acetaminobenzoate (isoprinosine), and 8-thioinosine with N,N-dimethylaminopropanol-2-p-acetaminobenzoate (OSI-177), inosine with L-arginine butyrate (OSI-2655), and 8-thioinosine with L-arginine butyrate (OSI-3648) were administered. The administered doses were 0.5, 5 and 50 mg/kg body weight. The compound OSI-2655 exceeded isoprinosine in PFC stimulation and phagocytosis activation. The compound OSI-3648 exceeded isoprinosine only in PFC stimulation in the case of immunization with a suboptimal SRBC dose. OSI-3648 stimulated the immune response in PRC better than isoprinosine, OSI-177, or OSI-2655, and maintained the ability to stimulate capture, but lost the ability to stimulate destruction processes of captured SRBC. L-Arginine butyrate in the doses equivalent to its content in the complexes did not affect the number of PFC. L-Arginine butyrate was able to stimulate the processes of destruction but its stimulation degree was inferior to the compound OSI-2655.
authors.affiliation: Medical Academy of Latvia, Riga.
authors.forename: L
authors.initials: L
authors.lastname: Poluektova
authors.forename: Y
authors.initials: Y
authors.lastname: Maurinsh
authors.forename: M
authors.initials: M
authors.lastname: Lidaks
authors.forename: N
authors.initials: N
authors.lastname: Gromova
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D002087:Butyrates / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007288:Inosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D012756:Sheep / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000318:Adrenergic beta-Agonists; D002087:Butyrates; D007141:Immunoglobulin Fc Fragments; D007288:Inosine; D001120:Arginine; C033018:arginine butyrate; D007545:Isoproterenol