title: Lipid peroxidation in hepatocellular carcinoma.
abstract: In this study, we measured free radicals and thiobarbituric acid-reactive substances (TBARS) in hepatocellular carcinoma and in non-cancerous liver parenchyma. There was a higher concentration of free radicals in malignant tissue than in non-cancerous tissue. In contrast, the level of TBARS was significantly (P < 0.01) lower than non-cancerous liver parenchyma. These paradoxical results suggested that antioxidative enzyme activity and/or inhibition of lipid peroxidation were higher in hepatocellular carcinoma.
authors.affiliation: First Department of Surgery, Okayama University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iwagaki
authors.forename: K
authors.initials: K
authors.lastname: Hamazaki
authors.forename: N
authors.initials: N
authors.lastname: Matsubara
authors.forename: M
authors.initials: M
authors.lastname: Hiramatsu
authors.forename: K
authors.initials: K
authors.lastname: Orita
authors.forename: A
authors.initials: A
authors.lastname: Mori
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
chemical_list: D016166:Free Radical Scavengers; D017392:Thiobarbituric Acid Reactive Substances