Prognostic value of DNA image cytometry in colorectal carcinoma.
OBJECTIVE
To investigate the diagnostic sensitivity and prognosis predicting of DNA image cytometry in colorectal carcinoma.


METHODS
We studied the ploidy status and other DNA cytometric parameters in 68 patients with colorectal carcinoma. In addition, clinical-histologic and follow-up information was collected for at least five years.


RESULTS
DNA histograms were available in all cases, showing a diploid DNA distribution pattern in 6 (8.8%), tetraploid in 21 (30.9%), hyperdiploid in 20 (29.4%) and hypertetraploid in 21 (30.9%). The differences in the correlation study between cytometric parameters and pathologic features were not statistically significant. Ploidy status and DNA malignancy grade were individually related to five-year survival (P < .005 and P < .05).


CONCLUSIONS
The data show that DNA image cytometry can provide valuable prognostic information on colorectal carcinomas and may prove useful in guiding adjuvant therapy in these patients.
Sampedro
A
A
Image Processing and Cytometry Service, University of Oviedo, Spain.
Urdiales
G
G
Martínez-Nistal
A
A
Riera
J
J
Hardisson
D
D
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D004273:DNA, Neoplasm / Q000032:analysis*; D003627:Data Interpretation, Statistical; D004171:Diploidy; D006801:Humans; D019044:Image Cytometry; D008875:Middle Aged; D011123:Polyploidy; D011379:Prognosis; D016019:Survival Analysis
D004273:DNA, Neoplasm