Structure of HLA molecules and immunosuppressive effects of HLA derived peptides.
Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these molecules, there is also evolutionary pressure to maintain the relatively monomorphic portions of these molecules. Drs. Krensky and Clayberger have found that synthetic peptides corresponding to linear sequences of HLA molecules have immunomodulatory effects both in vitro and in vivo. In this paper, they review the structure of HLA molecules and their studies of HLA derived peptides as novel immunotherapeutics. Members of the heat shock protein 70 family are implicated in the HLA derived peptide immunosuppressive pathway.
Krensky
A M
AM
Stanford University, California 94305-5119, USA.
Clayberger
C
C
D000483:Alleles; D017951:Antigen Presentation; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000235:genetics / Q000648:ultrastructure*; D000949:Histocompatibility Antigens Class II / Q000737:chemistry* / Q000235:genetics / Q000648:ultrastructure*; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000276:immunology* / Q000627:therapeutic use; D011485:Protein Binding; D013601:T-Lymphocytes / Q000276:immunology; D014158:Transcription, Genetic
D018840:HSP70 Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010455:Peptides