Synthesis and anti-inflammatory evaluation of new sulfamoylheterocarboxylic derivatives.
A series of new sulfamoylthiophene and sulfamoylpyrazole carboxylic acid derivatives was synthesized. Some of these compounds show interesting analgesic properties and significant nonsteroidal anti-inflammatory activities in several models of inflammation.
Díaz
J A
JA
Instituto de Química Médica, CSIC, Madrid, Spain.
Morante
M E
ME
Vega
S
S
Darias
V
V
Abdala
S
S
Delgado
L
L
de las Heras
B
B
Villar
A
A
Vivas
J M
JM
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001777:Blood Coagulation / Q000187:drug effects; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D009125:Muscle Relaxants, Central