title: Prediction of postoperative nausea and vomiting using a logistic regression model.
abstract: In a previous study, logistic regression analysis was used to determine the association of independent fixed patient factors with the incidence of postoperative nausea and vomiting (PONV). Female sex, previous history of PONV, use of postoperative opioids, previous history of motion sickness and an interaction between male sex and previous history of PONV were combined in an equation from which risk of PONV could be estimated. The present study was designed to test this equation in a group of patients with wide selection criteria. Data on 400 patients were collected in relation to pre-, per- and postoperative factors which may influence the incidence of PONV. The equation was used to predict PONV, and actual outcome was compared with that predicted. The overall incidence of PONV was 36%. The equation predicted an overall probability of PONV of 27.4%. If the model was used to define individual patients as predicted to have or not to have PONV, it was correct only 71% of the time. However, there was good agreement between the actual incidences of PONV and those predicted among the 16 risk groups created by the model.
authors.affiliation: Department of Epidemiology and Medical Statistics, London Hospital Medical College, University of London.
authors.forename: C C
authors.initials: CC
authors.lastname: Toner
authors.forename: C J
authors.initials: CJ
authors.lastname: Broomhead
authors.forename: I H
authors.initials: IH
authors.lastname: Littlejohn
authors.forename: G S
authors.initials: GS
authors.lastname: Samra
authors.forename: J G
authors.initials: JG
authors.lastname: Powney
authors.forename: M G
authors.initials: MG
authors.lastname: Palazzo
authors.forename: S J
authors.initials: SJ
authors.lastname: Evans
authors.forename: L
authors.initials: L
authors.lastname: Strunin
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D000758:Anesthesia / Q000009:adverse effects; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009325:Nausea / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012737:Sex Factors; D014839:Vomiting / Q000209:etiology*
chemical_list: D000701:Analgesics, Opioid