title: Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake.
abstract: We examined the validity of using the selenium level in a single biological specimen as a surrogate measure of usual intake. We used data from 77 free-living adults from South Dakota and Wyoming. Subjects provided multiple 1-day duplicate-plate food composites, repeated specimens of blood and toenails, and 24-hour urine collections. We developed a statistical calibration method that incorporated measurement error correction to analyze the data. The Pearson correlation coefficients between selenium intake and a single selenium status measure, after deattenuation to adjust for the effect of within-person variation in intake, were: 0.78 for whole blood, 0.74 for serum, 0.67 for toenails, and 0.86 for urine. We present formulas to estimate the intake of individuals, based on selenium levels in a single specimen of blood, toenails, or urine. In these data, the concentration of selenium in a single specimen of whole blood, serum, or toenails served reasonably well as a measure for ranking subjects according to long-term selenium intake but provided only a rough estimate of intake for each subject.
authors.affiliation: Department of Epidemiology, UCLA School of Public Health, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Longnecker
authors.forename: D O
authors.initials: DO
authors.lastname: Stram
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
authors.forename: O A
authors.initials: OA
authors.lastname: Levander
authors.forename: M
authors.initials: M
authors.lastname: Howe
authors.forename: C
authors.initials: C
authors.lastname: Veillon
authors.forename: P A
authors.initials: PA
authors.lastname: McAdam
authors.forename: K Y
authors.initials: KY
authors.lastname: Patterson
authors.forename: J M
authors.initials: JM
authors.lastname: Holden
authors.forename: J S
authors.initials: JS
authors.lastname: Morris
authors.forename: C A
authors.initials: CA
authors.lastname: Swanson
authors.forename: W C
authors.initials: WC
authors.lastname: Willett
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002149:Energy Intake; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009262:Nails / Q000737:chemistry*; D009501:Neutron Activation Analysis; D015596:Nutrition Assessment; D009752:Nutritional Status; D015203:Reproducibility of Results; D012643:Selenium / Q000097:blood* / Q000652:urine*; D013023:South Dakota / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014959:Wyoming / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D012643:Selenium