Apoptosis--molecular mechanisms and biomedical implications.
Apoptosis is a distinct form of cell death of importance in tissue development and homeostasis and in several diseases. This review summarizes current knowledge about the regulation and molecular mechanisms of apoptosis and discusses the potential role of disregulated apoptosis in several major diseases. Finally, we speculate that modulation of apoptosis may be a target in future drug therapy.
McConkey
D J
DJ
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Zhivotovsky
B
B
Orrenius
S
S
D017209:Apoptosis / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development; D017637:Clonal Deletion; D004194:Disease / Q000209:etiology*; D005786:Gene Expression Regulation; D007107:Immune System / Q000166:cytology / Q000254:growth & development; D007154:Immune System Diseases / Q000503:physiopathology; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology; D015398:Signal Transduction; D013950:Thymus Gland / Q000166:cytology / Q000254:growth & development