Anthelmintic activity of 6,7-diaryl-pteridines.
In a search for new anthelmintic compounds, some 6,7-diaryl-pteridines were synthesized from the corresponding diaminopyrimidines and aromatic aldehydes. Their anthelmintic activity was tested in vitro against Caenorhabditis elegans and Heligmosomoides polygyrus and in vivo against Trichinella spiralis. Structure-activity relationships are discussed.
Ochoa
C
C
Instituto de Quimica Medico, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
Rodríguez
J
J
López García
M L
ML
Ramón Martínez
A
A
Mercedes Martínez
M
M
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009351:Nematospiroides dubius / Q000187:drug effects; D011621:Pteridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017160:Trichinella spiralis / Q000187:drug effects; D014235:Trichinellosis / Q000188:drug therapy / Q000469:parasitology
D000871:Anthelmintics; D011621:Pteridines