title: Isolated hyperthermic limb perfusion chemotherapy in Merkel cell tumour: a case report.
abstract: Merkel cell carcinoma of the skin is a rare malignant tumour first described in 1972 by Toker. The optimal management of this disease has not been clearly defined, especially that of advanced locoregional disease. Surgery, radiotherapy and chemotherapy have been advocated separately or in combination, with less-than-optimal results. Localized high-dose chemotherapy has never been tried, although it would seem to be the logical step forward.
authors.affiliation: Department of Surgery, University of Wales College of Medicine, Cardiff, South Glamorgan, UK.
authors.forename: R
authors.initials: R
authors.lastname: Dawson
authors.forename: O M
authors.initials: OM
authors.lastname: Williams
authors.forename: R E
authors.initials: RE
authors.lastname: Mansel
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy* / Q000601:surgery; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D004210:Dissection; D006801:Humans; D006979:Hyperthermia, Induced; D007866:Leg; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan