Outcome of assisted reproduction technology in infertile couples of consanguineous marriage.
OBJECTIVE
The outcome of pregnancies resulting from assisted reproduction technology does not seem to differ from the outcome of those arising from spontaneous natural conception.


METHODS
There is increased risk of chromosomal abnormality in spontaneous natural pregnancies resulting from consanguineous marriage, with consequent higher rates of miscarriage, stillbirth, and congenital abnormalities.


RESULTS
This study has shown a trend of an increased miscarriage rate (but not statistically significant) in pregnancies achieved in infertile couples of consanguineous marriages by assisted reproductive technology.


CONCLUSIONS
Selecting embryos for transfer on the basis of their morphology does not appear to reduce the risk of chromosomal abnormality in these couples.
Egbase
P E
PE
IVF Centre, Maternity Hospital, Kuwait City, Kuwait.
al-Sharhan
M
M
al-Othman
S
S
al-Mutawa
M
M
Grudzinskas
J G
JG
D000022:Abortion, Spontaneous; D000328:Adult; D003241:Consanguinity; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D010043:Outcome and Process Assessment, Health Care; D011247:Pregnancy; D011256:Pregnancy Outcome