title: Cardiopulmonary bypass temperature, hematocrit, and cerebral oxygen delivery in humans.
abstract: BACKGROUND
  The neurologic effects of warm heart operations is a subject of popular interest. The purpose of this study was to examine the adequacy of cerebral oxygenation during normothermic cardiopulmonary bypass and better define the relationship between hematocrit, temperature, and brain oxygen delivery.
  
  
  METHODS
  Cerebral blood flow, metabolic rate, and oxygen delivery were measured in 60 patients randomized to normothermic (37 degrees C) or hypothermic (27 degrees C) cardiopulmonary bypass. The nitrous oxide saturation technique of Kety and Schmidt was used for cerebral blood flow determinations. Both temperature groups underwent moderate (31%) hemodilution.
  
  
  RESULTS
  During normothermic cardiopulmonary bypass, cerebral blood flow increased secondary to hemodilution and decreased cerebral vascular resistance; a normal matching of oxygen demand and delivery was maintained. During hypothermic bypass, hemodilution and hypothermia had essentially equal, opposing effects on cerebral vascular resistance and blood flow. With hypothermia, brain oxygen demand and delivery were both reduced but not closely coupled.
  
  
  CONCLUSIONS
  From the standpoint of global cerebral perfusion and oxygenation, our data support the practice of "warm" heart operations. It clarifies the marked influence of hematocrit on cerebral blood flow and delineates the interaction of temperature and hematocrit on cerebral oxygen delivery. It also suggests that additional investigation to better define "temperature-appropriate" hemodilution during cardiopulmonary bypass is indicated.
authors.affiliation: Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Cook
authors.forename: W C
authors.initials: WC
authors.lastname: Oliver
authors.forename: T A
authors.initials: TA
authors.lastname: Orszulak
authors.forename: R C
authors.initials: RC
authors.lastname: Daly
authors.forename: R D
authors.initials: RD
authors.lastname: Bryce
mesh_terms: D001831:Body Temperature; D001921:Brain / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D002560:Cerebrovascular Circulation; D006400:Hematocrit; D006438:Hemodilution; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D014655:Vascular Resistance
chemical_list: D010100:Oxygen