title: The expression of both amphetamine-conditioned place preference and pentylenetetrazol-conditioned place aversion is attenuated by the NMDA receptor antagonist (+/-)-CPP.
abstract: The present study addressed the ability of the NMDA receptor antagonist (+/-)-CPP ((+/-)-3-(2-carboxy-piperazine-4-yl)-propyl-1-phosphonic acid) to block the expression of amphetamine (AMPH)-conditioned place preference (CPP) or pentylenetetrazol (PTZ)-conditioned place aversion (CPA) in male Wistar rats. During a 4-day conditioning period, daily injections of AMPH (1.5 mg/kg, s.c.), PTZ (20 mg/kg, i.p.) and their vehicles were paired with two distinctive compartments of the shuttle box (balanced procedure). Rats pretreated with saline showed significant preference for the AMPH-paired or aversion of PTZ-paired compartments. Pretreatment with (+/-)-CPP (10-30 mg/kg, i.p.) dose-dependently blocked the expression of both CPP and CPA. These data suggest that NMDA receptors are implicated in the expression of conditioned behaviors.
authors.affiliation: Department of Pharmacology, Pavlov Medical University, St. Petersburg, Russia.
authors.lastname: Bespalov AYu
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D012931:Social Environment
chemical_list: D018691:Excitatory Amino Acid Antagonists; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; D003913:Dextroamphetamine; D010433:Pentylenetetrazole