In vitro assessment of various cytochromes P450 and glucuronosyltransferases using the antiarrhythmic propafenone as a probe drug.
Kroemer
H K
HK
Dr. Margarete Fischer-Bosch-Institute für Klinische Pharmakologie, Stuttgart, Germany.
Botsch
S
S
Heinkele
G
G
Schick
M
M
D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D066298:In Vitro Techniques; D006899:Mixed Function Oxygenases / Q000378:metabolism; D015335:Molecular Probes; D011405:Propafenone / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics
D000889:Anti-Arrhythmia Agents; D005965:Glucuronates; D015335:Molecular Probes; D011405:Propafenone; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D019388:Cytochrome P-450 CYP1A2; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; D014453:Glucuronosyltransferase