title: Allergic contact dermatitis to artificial fingernails prepared from UV light-cured acrylates.
abstract: BACKGROUND
  Contact dermatitis from artificial nails made from self-curing acrylic resins is occasionally reported. Recently, UV light-cured products introducing new acrylics have become available.
  
  
  OBJECTIVE
  Our purpose was to identify relevant allergens in commercial light-curing products by patch tests and to evaluate the efficacy of "hypoallergenic" products by inclusion into the test series.
  
  
  METHODS
  Patients wearing photobonded acrylic nails who had perionychial and subonychial eczema were patch tested with an acrylate battery and "hypoallergenic" commercial products.
  
  
  RESULTS
  Triethyleneglycol dimethacrylate, hydroxyfunctional methacrylates, and (meth)-acrylated urethanes proved to be relevant allergens in photobonded nail preparations. Methacrylated epoxy resin sensitization was not observed. All "hypoallergenic" products provoked positive reactions.
  
  
  CONCLUSIONS
  The omission of irritant methacrylic acid in UV-curable products does not reduce the high sensitizing potential of new acrylates. In contrast to the manufacturers' declarations, all "hypoallergenic" products continue to include acrylate functional monomers and therefore continue to cause allergic sensitization.
authors.affiliation: Dermatologic and Pediatric Allergy Clinic, Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Hemmer
authors.forename: M
authors.initials: M
authors.lastname: Focke
authors.forename: F
authors.initials: F
authors.lastname: Wantke
authors.forename: M
authors.initials: M
authors.lastname: Götz
authors.forename: R
authors.initials: R
authors.lastname: Jarisch
mesh_terms: D000179:Acrylates / Q000009:adverse effects; D000180:Acrylic Resins / Q000009:adverse effects* / Q000302:isolation & purification / Q000528:radiation effects; D000485:Allergens / Q000009:adverse effects / Q000302:isolation & purification; D017438:Bisphenol A-Glycidyl Methacrylate / Q000009:adverse effects; D003188:Composite Resins / Q000009:adverse effects; D003358:Cosmetics / Q000009:adverse effects* / Q000528:radiation effects; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004485:Eczema / Q000139:chemically induced; D004853:Epoxy Resins; D005260:Female; D005385:Fingers; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D008689:Methacrylates / Q000009:adverse effects; D009260:Nail Diseases / Q000139:chemically induced*; D009262:Nails; D010328:Patch Tests; D011092:Polyethylene Glycols / Q000009:adverse effects; D011109:Polymethacrylic Acids / Q000009:adverse effects; D011140:Polyurethanes / Q000009:adverse effects; D014466:Ultraviolet Rays
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D000485:Allergens; D003188:Composite Resins; D003358:Cosmetics; D004853:Epoxy Resins; D007509:Irritants; D008689:Methacrylates; D011109:Polymethacrylic Acids; D011140:Polyurethanes; C029824:urethane dimethacrylate luting resin; C020946:triethylene glycol dimethacrylate; C008384:methacrylic acid; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; C005044:hydroxyethyl methacrylate; C032490:n-butyl acrylate; C032802:hydroxypropyl methacrylate