title: B cell lineage-specific activator protein (BSAP). A player at multiple stages of B cell development.
abstract: B cell lineage-specific activator protein (BSAP), encoded by the Pax 5 gene, is a critical modulator of early B cell differentiation. Binding sites for BSAP have been identified in the promoters of multiple genes as well as at multiple sites within the IgH locus. While in vivo target sites critical for early B cell differentiation have not yet been identified, candidate sites include a 3 IgH enhancer that is active early in B cell development. BSAP may play an additional role later in development, such as in the regulation of isotype class switching.
authors.affiliation: Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Michaelson
authors.forename: M
authors.initials: M
authors.lastname: Singh
authors.forename: B K
authors.initials: BK
authors.lastname: Birshtein
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D001665:Binding Sites; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007134:Immunoglobulin Switch Region; D009687:Nuclear Proteins / Q000276:immunology / Q000378:metabolism*; D051757:PAX5 Transcription Factor; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D014157:Transcription Factors