Auditory event-related potentials, auditory digit span, and clinical symptoms in chronic schizophrenic men on neuroleptic medication.
The aim of this study was to test predictions based on Grossberg's theories of overarousal in neural networks as related to schizophrenic symptomatology. We predicted that symptoms of blunted affect and volition would be associated with reduced P300 amplitude, while impaired attention and short-term memory and symptoms of disorganization would be associated with increased N200 and P300 latency. Event-related potentials, elicited by auditory stimuli, were recorded in 20 chronic schizophrenic men on neuroleptic medication and an age- and sex-matched control group of 20 normal volunteers. The amplitude and latency values of the N200 and P300 waves at the vertex (Cz) were compared with clinical ratings (the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms) and with neuropsychological test scores by means of Spearman rank correlation coefficient. The patients showed a reduced P300 amplitude and an increased N200 latency. No correlation was found between the P300 amplitude and the symptom scores. The N200 latency was negatively correlated with auditory digit span and positively correlated with high global scores for attentional impairment, alogia, and positive formal thought disorder. Our initial predictions are partly confirmed by the apparent association between increased N200 latency and symptoms of disorganization.
Stefánsson
S B
SB
Department of Psychiatry, Landspítalinn, Kleppur, Reykjavík, Iceland.
Jónsdóttir
T J
TJ
D000342:Affective Symptoms / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D002908:Chronic Disease; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D009042:Motivation; D009415:Nerve Net / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012691:Serial Learning / Q000187:drug effects* / Q000502:physiology; D013067:Speech Perception / Q000187:drug effects* / Q000502:physiology
D014150:Antipsychotic Agents