title: Extracellular matrix and beta 1 integrin expression in nodal and extranodal T-cell lymphomas.
abstract: Since non-Hodgkin's lymphoma (NHL) cells interact with surrounding structures similarly to their normal counterparts, micro-environmental changes and the aberrant expression of adhesion molecules are considered to be of importance in lymphomagenesis. In this immunohistochemical study, the composition of several extracellular matrix (ECM) components and the expression of their beta 1 integrin receptors were examined in nodal and extranodal T-cell NHLs. Except for the T-lymphoblastic NHLs, almost all T-NHLs displayed abundant deposition of matrix and considerable expression of the alpha 4 and beta 1 integrin chains. This is in contrast to B-cell NHLs, which show ECM patterns comparable to those in reactive lymphoid tissue or, in cases of high-grade malignancy, active matrix degradation and very low expression or absence of beta 1 integrins, as previously described. This difference is probably based on distinct cytokine production in B- and T-cell malignancies. As in B-NHL, nodal and extranodal T-NHLs of the same morphological subtype exhibit identical ECM patterns, which suggests that malignant lymphoid cells of both B and T origin create at least part of their own specific micro-environment.
authors.affiliation: Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: L H
authors.initials: LH
authors.lastname: Jaspars
authors.forename: P
authors.initials: P
authors.lastname: Bonnet
authors.forename: E
authors.initials: E
authors.lastname: Bloemena
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
mesh_terms: D003094:Collagen / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D019012:Integrin beta1 / Q000378:metabolism*; D007797:Laminin / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D016410:Lymphoma, T-Cell, Cutaneous / Q000378:metabolism; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism
chemical_list: D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D019012:Integrin beta1; D007797:Laminin; D009363:Neoplasm Proteins; D003094:Collagen