title: [Synovial volume of healthy and arthrotic human knee joints].
abstract: The volume of synovial fluid in human knee joints was determined by the dilution method through the intra-articular injection of 35 ml 0.5% hydroxyethyl starch in saline. In 15 control knees the mean synovial volume was 6.7 +/- 2.3 ml (mean +/- SD). In patients with latent gonarthrosis we found a mean intra-articular volume of 13.6 +/- 7.4 ml (n = 21) and in activated gonarthrosis 24.2 +/- 16.3 ml (n = 34). All 3 groups differ significantly. After entire aspiration of the effusion, we found yet 13.4 +/- 4.4 ml (n = 32) synovial fluid in the knee joint. Using the dilution method, we obtained a punctate from each knee joint. The punctates can be used for biochemical investigations. Since the dilution factors of the punctates are known, the concentrations of HWM parameters in the original synovial fluid can be calculated.
authors.affiliation: Orthopädische Universitätsklinik und Poliklinik, Charité, Humboldt-Universität zu Berlin.
authors.forename: H H
authors.initials: HH
authors.lastname: Heilmann
authors.forename: K
authors.initials: K
authors.lastname: Lindenhayn
authors.forename: H U
authors.initials: HU
authors.lastname: Walther
mesh_terms: D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007201:Indicator Dilution Techniques; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000503:physiopathology*; D010003:Osteoarthritis / Q000473:pathology / Q000503:physiopathology*; D010960:Plasminogen Activators / Q000032:analysis; D012016:Reference Values; D013582:Synovial Fluid / Q000502:physiology*; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Das Synovia-Volumen gesunder und arthrotischer menschlicher Kniegelenke.