Efficacy and pharmacokinetics of triclabendazole in buffalo with induced fasciolosis.
A study was conducted to understand pharmacokinetics and flukicidal activity of intraruminal administration of triclabendazole (TCBZ) at 12.0, 24.0 and 36.0 mg kg-1 body weight in experimentally Fasciola gigantica-infected buffaloes on Week 2 and 10 post-infection. No fluke eggs in faeces and no flukes could be recovered from the liver of buffaloes following intraruminal administration of triclabendazole at 24.0 and 36.0 mg kg-1 body weight both on Weeks 2 and 10 post-infection, while the recommended therapeutic dose at 12.0 mg kg-1 body weight was 19-23% effective. Pharmacokinetic analysis of the data revealed a significantly higher (P < 0.05) concentration maximum of both the metabolites and area under concentration-time curve of TCBZ-SO2 in animals treated at 12.0 mg kg-1 body weight on Week 10 post-infection, whereas a significantly higher area under the concentration-curve and elimination half-life of both the metabolites and significantly higher concentration maximum and area under the concentration-time curve of both the metabolites were observed in animals treated on Week 10 post-infection at the dose rates of 24.0 and 36.0 mg kg-1 body weight, respectively. Bioavailability of triclabendazole was more in buffaloes with mature flukes than with immature flukes.
Sanyal
P K
PK
Biotechnology Laboratory, National Dairy Development Board, Gujarat, India.
Gupta
S C
SC
D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001682:Biological Availability; D002020:Buffaloes; D005209:Fasciola / Q000254:growth & development / Q000302:isolation & purification; D005211:Fascioliasis / Q000188:drug therapy*; D005243:Feces / Q000469:parasitology; D006207:Half-Life; D008099:Liver / Q000469:parasitology; D008657:Metabolic Clearance Rate; D010270:Parasite Egg Count; D013997:Time Factors; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole