title: Effect of cimetidine on weight gain in rats.
abstract: Effect on food intake and body weight was studied in rats after oral administration of cimetidine. Rats in experimental (E) group exhibited less increase in food intake (20%) compared to control (C) rats (43.8%). Mean body weight showed first reduction (-9.56%) and then very small increment in experimental animals compared to gradual gain in body weight in control animals. At the end of 6 weeks, total gain in body weight was 22.5 gm in rats of E group against 53.8 gm in rats of C group. Food efficiency ratio (FER) showed much reduction (1.13) in E group against 2.07 in C group. These results demonstrate that cimetidine (H2-receptor blocker) may have ability to reduce food intake and body weight in rats.
authors.affiliation: Department of Physiology, Medical College and Hospital, Rohtak, Haryana India.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: P I
authors.initials: PI
authors.lastname: Singh
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D006635:Histamine H2 Antagonists; D002927:Cimetidine