Reduced long-term potentiation in the dentate gyrus of mGlu1 receptor-mutant mice in vivo.
Long-term potentiation in the dentate gyrus was studied in vivo in mutant mice lacking the metabotropic glutamate (mGlu) subtype 1 receptor. Long-term potentiation was induced in wild type animals (n = 7), but was reduced in mice lacking this receptor subtype (n = 7). These data suggest that mGlu receptors may be involved in the induction or maintenance of synaptic plasticity or that these receptors are required during development to establish this plasticity.
Bordi
F
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Pharmacology Department, Glaxo-Wellcome Research Laboratories, Verona, Italy. fb23261@ggr.co.uk
D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000235:genetics* / Q000502:physiology*; D008297:Male; D051379:Mice; D017470:Receptors, Glutamate / Q000235:genetics* / Q000378:metabolism*
D017470:Receptors, Glutamate