Mammalian artificial chromosomes.
The development of candidate vectors and of techniques for their manipulation by sequence targeting suggest that a mini-chromosome vector system for the mouse germline may be at hand. Mini-chromosome vectors should allow new sorts of genetic problems to be addressed experimentally and may accelerate the process of gene identification.
Brown
W
W
CRC Chromosome Molecular Biology Group, Biochemistry Department, Oxford University, UK. wrab@bioch.ox.sc.uk
Heller
R
R
Loupart
M L
ML
Shen
M H
MH
Chand
A
A
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D002460:Cell Line; D002645:Chickens; D002875:Chromosomes; D005822:Genetic Vectors; D006801:Humans; D008322:Mammals; D051379:Mice