title: Seroprevalence of Helicobacter pylori in a birth cohort of 21-year-old New Zealanders.
abstract: OBJECTIVE
  To determine the seroprevalence of Helicobacter pylori (H. pylori) in a subset of a birth cohort of New Zealanders at age 21 and examine the association with risk factors and digestion-related symptoms.
  
  
  METHODS
  Assay of serum collected from members of a longitudinal study during 1993-94 and a survey of risk factors and digestion-related symptoms by interview and questionnaire.
  
  
  METHODS
  Serum from 785 sample members (413 males, 372 females) of the 950 participating in the Dunedin Multidisciplinary Health and Development Study (DMHDS) at age 21 was analysed for H. pylori antibodies. Serum samples (n = 579) from the cohort at age 11 collected in 1983 were analysed for those who were seropositive at age 21.
  
  
  RESULTS
  The seroprevalence of H. pylori at age 21 was 4.1% (32/785), with proportionally more males in the seropositive group (chi 2 = 6.7, P < 0.01). Serum samples taken at age 11 were available for 19 of the seropositive group and 74% of these (11 males, three females) were seropositive. The seropositive group at age 21 was no different in the size of their families, but at age 5 contained proportionally more individuals from families of low socioeconomic status (SES) (chi 2 = 6.1, P < 0.05). There was no difference between the two groups in terms of upper gastrointestinal tract symptoms, recent use of medications, smoking or alcohol consumption.
  
  
  CONCLUSIONS
  The seroprevalence of H. pylori among a birth cohort of 21-year-old New Zealanders is significantly lower than among most populations of about the same age in other countries. Seropositivity is higher in males and among families of lower SES, and is not associated with digestion-related symptoms. The seroconversion rate after age 11 appears to be low.
authors.affiliation: School of Pharmacy, University of Otago, Dunedin, New Zealand.
authors.forename: J P
authors.initials: JP
authors.lastname: Fawcett
authors.forename: J P
authors.initials: JP
authors.lastname: Shaw
authors.forename: M
authors.initials: M
authors.lastname: Cockburn
authors.forename: M
authors.initials: M
authors.lastname: Brooke
authors.forename: G O
authors.initials: GO
authors.lastname: Barbezat
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors
chemical_list: D000907:Antibodies, Bacterial