Effective hemodialysis and hemofiltration driven by an extracorporeal membrane oxygenation pump in infants with hyperammonemia.
Two infants with urea cycle disorders had life-threatening hyperammonemia within the first 5 days of life. Both patients were small for dates, poorly oxygenated, and hemodynamically unstable. We employed a combination of extracorporeal oxygenation and hemodialysis to provide high-flow filtration in a controlled system to rapidly detoxify both patients.
Summar
M
M
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Pietsch
J
J
Deshpande
J
J
Schulman
G
G
D000641:Ammonia / Q000097:blood*; D003128:Coma / Q000209:etiology / Q000628:therapy*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008661:Metabolism, Inborn Errors / Q000097:blood* / Q000150:complications; D006435:Renal Dialysis / Q000379:methods*
D000641:Ammonia