Repression of acute gastric mucosal lesions by antioxidant-containing fraction from fermented products of okara (bean-curd residue).
A crude antioxidant preparation from fermented okara (NTX) was examined for its protection against the pathogenesis of gastric ulcer in water-immersed rats. The areas of gastric mucosal lesions as well as the levels of thiobarbituric acid-reactive substances, prostaglandin E2 and hyaluronic acid in the gastric mucosa were measured in relation to the time elapsed after the imposition of stress. Comparison with those parameters in alpha-tocopherol-treated groups revealed that NTX exerted an anti-inflammatory effect on gastric injury, probably by functioning as a free radical scavenger.
Yokota
T
T
Division of Pathology, Nippon Medical School, Kawasaki, Japan.
Ohami
H
H
Ohishi
H
H
Hattori
T
T
Watanabe
K
K
D000818:Animals; D000975:Antioxidants; D015232:Dinoprostone / Q000378:metabolism; D007887:Fabaceae; D005285:Fermentation; D005753:Gastric Mucosa / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism; D007101:Immersion; D007700:Kinetics; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013272:Stomach Diseases / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications / Q000209:etiology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D006820:Hyaluronic Acid; D015232:Dinoprostone