Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
Rusconi
S
S
Infectious Disease Unit, Massachusetts General Hospital, Boston 02114, USA.
Moonis
M
M
Merrill
D P
DP
Pallai
P V
PV
Neidhardt
E A
EA
Singh
S K
SK
Willis
K J
KJ
Osburne
M S
MS
Profy
A T
AT
Jenson
J C
JC
Hirsch
M S
MS
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001667:Binding, Competitive; D015704:CD4 Antigens / Q000187:drug effects*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D002461:Cell Line, Transformed; D015699:HIV Envelope Protein gp120 / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008252:Macaca fascicularis; D009282:Naphthalenesulfonates / Q000494:pharmacology* / Q000633:toxicity; D011108:Polymers / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins / Q000187:drug effects
D000998:Antiviral Agents; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D009282:Naphthalenesulfonates; D011108:Polymers; D011994:Recombinant Proteins