The recognition of DNA damage.
DNA strand breaks are potentially mutagenic and must, therefore, be recognized and repaired. Recent work has identified DNA polymerase epsilon, Ku, and proteins such as DNA-PKcs, Mec1 and Tel1 as key players in DNA damage recognition pathways. Studies on these and other factors have provided important insights into the mechanisms of DNA repair and how DNA damage signals are transduced to the transcription and cell cycle machineries. This work also suggests how deficiencies in DNA damage detection systems can result in genetic instability and cancer.
Jackson
S P
SP
Department of Zoology, Cambridge University, UK. spj13@mole.bio.cam.ac.uk
D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D004259:DNA-Directed DNA Polymerase; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D011065:Poly(ADP-ribose) Polymerases; D017346:Protein Serine-Threonine Kinases; C497263:PRKDC protein, human