title: [Nocturnal oxygen administration and cardiac arrhythmias during Cheyne-Stokes respiration in patients with heart failure].
abstract: Cheyne-Stokes respiration (CSR) is common during sleep in patients with severe congestive heart failure. It is not clear, if there is a relation between CSR and arrhythmias. Therefore in this study the impact of the nocturnal CSR on ventricular arrhythmias and the heart rate, as well as the influence of nasal nocturnal oxygen on CSR and sleep was studied. In a randomized, double-blind, crossover study 22 patients were assigned to 1 week each of oxygen and room air. The age of the patients was 57 +/- 10 years. Their mean left ventricular ejection fraction was 18.9 +/- 6.4%. Breathing oxygen significantly reduced the duration of CSR by over 50% (162 +/- 142 vs 88 +/- 106 min, p < 0.05). Sleep did improve as evidenced mainly by less arousals (21 +/- 13 vs 15 +/- 9/h total sleep time; p < 0.05) and stage 1 sleep as well as more stage 2 and slow wave sleep. Nocturnal oxygen resulted in a reduction of ventricular arrhythmias for ventricular ectopic beats (53.1 +/- 157.7 vs 44.7 +/- 97.1/h), couplets (9.0 +/- 38.3 vs 3.7 +/- 14.3/h) and tachycardias (1.8 +/- 7.2 vs 0.4 +/- 0.8/h). Due to the high day-today variability these differences were not significant, but the decrease of average nocturnal heart rate with oxygen was (71 +/- 14 vs 68 +/- 14/min; p < 0.05). In conclusion, nocturnal oxygen causes a reduction of CSR, an improvement of sleep and a decrease of arousals. A significant reduction of arrhythmias by nocturnal oxygen could not be proved.
authors.affiliation: Abteilung für Kardiologie und Pneumologie, Göttingen.
authors.forename: G
authors.initials: G
authors.lastname: Hagenah
authors.forename: S
authors.initials: S
authors.lastname: Andreas
authors.forename: C
authors.initials: C
authors.lastname: Clemens
authors.forename: H R
authors.initials: HR
authors.lastname: Figulla
authors.forename: H
authors.initials: H
authors.lastname: Kreuzer
mesh_terms: D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D002639:Cheyne-Stokes Respiration / Q000503:physiopathology / Q000628:therapy*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000503:physiopathology / Q000628:therapy; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000503:physiopathology / Q000628:therapy*; D013318:Stroke Volume / Q000502:physiology; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000628:therapy
vernacular_title: Nächtliche Sauerstoffgabe und Herzrhythmusstörungen während Cheyne-Stokes-Atmung bei Patienten mit Herzinsuffizienz.