[The membrane mechanism of the development of tonic stress in the heart muscle of rats under the action of antimembrane antibodies].
Action of antibodies specific to the myocardial sarcolemma of rat on contraction of the isolated cardiac muscle was investigated. It is found that initially antibodies cause stimulation of the cell function (an increase in force or frequency of contractions). Then a slow and progressive inhibition of phasic contractions and development of tonic tension and contracture are observed. Those different effects indicate that antibodies induce an increase in intracellular Ca2+ concentration. The direct measurements have shown that the Na(+)-K(+)-pump activity is depressed by the action of antibodies. Possibly one of the mechanisms of inhibition is lipid peroxidation of the membrane under the influence of antibodies.
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D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000918:Antibody Specificity; D002462:Cell Membrane / Q000276:immunology / Q000502:physiology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009129:Muscle Tonus / Q000187:drug effects* / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D012508:Sarcolemma / Q000201:enzymology / Q000276:immunology
D000906:Antibodies; D000251:Adenosine Triphosphatases
Do membrannoho mekhanizmu rozvytku tonichnoï napruhy sertsevoho m'iaza shchuriv pry diï antymembrannykh antytil.