title: Effects of aerobic and anaerobic physical conditioning on fibrinolysis.
abstract: The effects of aerobic and anaerobic physical conditioning on fibrinolysis were studied before and immediately after physical exercise. Moderately active controls (group A) were compared with aerobically- (group B) or anaerobically-conditioned (group C) subjects. Comparison of the resting parameters revealed that FgDP were significantly higher in group B as a compared to groups A and C. FbDP did not significantly differ between groups B and C and were significantly lower in group A. t-PA antigen and PAI antigen did not significantly differ between the three groups, but t-PA activity was elevated and PAI activity and t-PA/PAI complexes were reduced in group B. Following a maximal exercise test on the treadmill both FbDP and FgDP were significantly increased in all groups, although values for FbDP in group B and values for FgDP in group C reached a higher level than in group A. t-PA antigen and t-PA activity were also increased in the three groups. PAI activity was significantly reduced in groups A and C. t-PA/PAI complexes were significantly enhanced in all cases, but increased to a lower degree in group B. These results indicate that both aerobic and anaerobic physical conditioning induce activation of the fibrinolytic system.
authors.affiliation: Institute of Physical Education, University of León, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: De Paz
authors.forename: J
authors.initials: J
authors.lastname: Lasierra
authors.forename: J G
authors.initials: JG
authors.lastname: Villa
authors.forename: E
authors.initials: E
authors.lastname: Vilades
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez-Gallego
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D010960:Plasminogen Activators / Q000502:physiology; D012420:Running / Q000502:physiology*; D010959:Tissue Plasminogen Activator / Q000097:blood; D014891:Weight Lifting / Q000502:physiology*
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator