Clinical and pathological features of protein-losing glomerular disease in the dog: a review of 137 cases (1985-1992).
Medical records of 137 dogs with protein-losing glomerular disease (PLGD) were evaluated. Cases with amyloidosis (23%) were more likely to be azotemic at presentation, with significantly greater proteinuria and hypoalbuminemia than those cases with glomerulonephritis (GN; 77%). The prognosis for all cases was poor, with a median survival time of just 28 days. The most common causes of death in cases with idiopathic disease were chronic renal failure (69.5%) or thromboembolic complications (22.2%). Progression of glomerular disease was unpredictable, with no apparent correlation between survival time and biochemical parameters at presentation.
Cook
A K
AK
Veterinary Medical Teaching Hospital, Davis, California, USA.
Cowgill
L D
LD
D000686:Amyloidosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary; D000818:Animals; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D004283:Dog Diseases / Q000097:blood / Q000401:mortality / Q000473:pathology*; D004285:Dogs; D005260:Female; D005916:Globulins / Q000032:analysis; D005921:Glomerulonephritis / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000473:pathology / Q000662:veterinary; D008297:Male; D011507:Proteinuria / Q000401:mortality / Q000473:pathology / Q000662:veterinary; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D013923:Thromboembolism / Q000401:mortality / Q000473:pathology / Q000662:veterinary
D005916:Globulins; D012709:Serum Albumin; D002784:Cholesterol; D003404:Creatinine