[The characteristics of the immune response to the polysaccharide determinants of Streptococcus group A in rheumatism].
As shown in this study, the formation of antibodies, at least, to the determinants (DT) of polysaccharide of group A streptococcus (A-PS), common with epidermal antigens, occurs in rheumatic fever. Two DT include N-acetylglucosamine; DT common with epidermal basal cell antigen (DT-1) and DT common with antigen of the perinuclear zone of the cytoplasm of cells of differentiated layers (DT-2). Two other DT seem to contain only rhamnose; DT common with the cytoplasm of cells of differentiated layers (DT-3) and DT common with epidermal antigen, characteristic of the cytoplasm of cells of all epidermal layers (DT-4). Conclusion has been made that the presence of autoantibodies to epidermal basal cell antigens, common with DT-1 and DT-4 of A-PS, may serve as an additional indicator of the activity of the rheumatic process. Autoantibodies to cross-reacting DT-4 of A-PS are indicative of the chronization of the process with a tendency to relapses of rheumatic fever.
Borodiiuk
N A
NA
Bazanova
E A
EA
Nesterenko
V G
VG
D000117:Acetylglucosamine / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000937:Antigen-Antibody Reactions; D001323:Autoantibodies / Q000097:blood; D002648:Child; D004817:Epidermis / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012008:Recurrence; D012210:Rhamnose / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology*; D012214:Rheumatic Heart Disease / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology*
D000907:Antibodies, Bacterial; D001323:Autoantibodies; D000939:Epitopes; D011135:Polysaccharides, Bacterial; D012210:Rhamnose; D000117:Acetylglucosamine
Osobennosti immunnogo otveta na determinanty polisakharida streptokokka gruppy A pri revmatizme.