[Role of Langerhans cells in the physiopathology of atopic dermatitis].
The demonstration of IgE receptors on the surface of epidermal dendritic cells and on other antigen presenting cells is a crucial element in the understanding of the pathophysiological role of these cells in the genesis of atopic disease, and especially the atopic dermatitis (AD). The sensibilisation phase to an aeroallergen at the level of nasal or bronchial mucosa and even at the skin may be mediated by dendritic cells expressing Fc epsilon RI. Distinct forms of AD may then represent the equivalent of the ellicitation phase of the classical allergic contact dermatitis. Fc epsilon RI would lead, via specific IgE, to an efficient antigen capture, to the activation of the dendritic cells and finally to an antigen presentation. Thus, AD may represent the paradigma of an IgE-mediated type IV reaction.
Bieber
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Clinique et Policlinique Dermatologique, Université Ludwig-Maximilian, MUNICH, Allemagne.
D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007801:Langerhans Cells / Q000276:immunology* / Q000378:metabolism; D017455:Receptors, IgE / Q000276:immunology*
D016207:Cytokines; D017455:Receptors, IgE; D007073:Immunoglobulin E
Place des cellules de Langerhans dans la physiopathologie de la dermatite atopique.