Monitoring of lithium levels in human serum after therapy with lithium preparations by capillary isotachophoresis.
An isotachophoretic method for the evaluation of the level of lithium salts in serum samples was optimized. Use of operating systems containing polyethylene glycol permitted the separation of cationically migrating components from Li (i.e., Na, K and Ca). The pretreatment of serum samples involves only appropriate dilution with demineralized water depending on the concentration of the major components such as sodium. The lithium levels were studied both in model samples and serum from patients treated with lithium preparations.
Valásková
I
I
Department of Pharmaceutical Analysis and Nuclear Pharmacy, Comenius University, Bratislava, Slovak Republic.
Balázová
J
J
Havránek
E
E
D019075:Electrophoresis, Capillary / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008094:Lithium / Q000097:blood* / Q000627:therapeutic use*; D011092:Polyethylene Glycols; D012044:Regression Analysis
D011092:Polyethylene Glycols; D008094:Lithium