title: Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay "unique positive' NTP carcinogens.
abstract: In a collaborative study organized under the JEMS MMS, nine mouse lymphoma assay (MLA) "unique positive' NTP rodent carcinogens were re-evaluated by an in vitro chromosomal aberration assay using Chinese hamster lung fibroblast cells (CHL/IU). Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloroethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy). These six chemicals, therefore, are not uniquely positive in the MLA. The difference between the NTP results and ours might be due to the use of different cell lines and protocols, and in some cases, to different interpretations of polyploidy. The remaining three chemicals, benzyl acetate, cinnamyl anthranilate and trichloroethylene, were negative in this study.
authors.affiliation: Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan. matsuoka@nihs.go.jp
authors.forename: A
authors.initials: A
authors.lastname: Matsuoka
authors.forename: K
authors.initials: K
authors.lastname: Yamakage
authors.forename: H
authors.initials: H
authors.lastname: Kusakabe
authors.forename: S
authors.initials: S
authors.lastname: Wakuri
authors.forename: M
authors.initials: M
authors.lastname: Asakura
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: K F
authors.initials: KF
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Hatanaka
authors.forename: M
authors.initials: M
authors.lastname: Ishidate
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Odawara
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Sofuni
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D002869:Chromosome Aberrations; D006224:Cricetinae; D005069:Evaluation Studies as Topic; D006076:Government; D008223:Lymphoma; D051379:Mice; D014407:Tumor Cells, Cultured; D014481:United States
chemical_list: D002273:Carcinogens