Albumin is an important vascular tonus regulator as a reservoir of nitric oxide.
Plasma albumin reacts with nitric oxide (NO) to form S-nitroso-albumin (albumin-S-NO). The present study was designed to elucidate whether NO-induced response on blood pressure may differ between analbuminemic rats (NAR) and normal rats. When NOC7, a NO donor, was intravenously injected in rats, blood pressure decreased and the initial depressor response was the same in both the NAR and the normal rats. However, the duration of NO-induced hypotension was 0.5 times longer in NAR than in the normal rat. After NOC7 injection, plasma thiol levels decreased and S-nitrosothiols levels increased in the normal rats, whereas these levels slightly changed in NAR. These results suggested that NO reacts with albumin-SH, resulting in albumin-S-NO formation, which produces a continuous hypotensive response in blood pressure as a slow releaser of NO.
Minamiyama
Y
Y
Department of Biochemistry, Osaka City University Medical School, Japan.
Takemura
S
S
Inoue
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood; D006706:Homeostasis; D007275:Injections, Intravenous; D008297:Male; D009129:Muscle Tonus / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000494:pharmacology / Q000502:physiology*; D009603:Nitroso Compounds / Q000097:blood; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D012016:Reference Values; D026422:S-Nitrosoglutathione; D012709:Serum Albumin / Q000172:deficiency / Q000502:physiology*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000097:blood; D013997:Time Factors; D014226:Triazenes / Q000494:pharmacology
C100973:(1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-3-aminopropyl)-3-methyl-1-triazene; D009603:Nitroso Compounds; C091665:S-nitrosoalbumin; D012709:Serum Albumin; D013438:Sulfhydryl Compounds; D014226:Triazenes; D012710:Serum Albumin, Bovine; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D010208:Papaverine; D005978:Glutathione