Prevention of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by treatment with a monoclonal anti-CD4 antibody.
Untreated control OS chickens develop spontaneous autoimmune thyroiditis (SAT). In contrast, OS chickens treated with a monoclonal anti-CD4 antibody failed to develop SAT. The preventive effect of anti-CD4 antibody on SAT was associated with the marked depletion of CD4+ T-cells by anti-CD4 treatment. These results indicate that CD4+ T-cells play a crucial role in SAT of OS chickens.
Cihak
J
J
Institute of Animal Physiology, University of Munich, Federal Republic of Germany.
Hoffmann-Fezer
G
G
Wasl
M
M
Merkle
H
H
Kaspers
B
B
Hála
K
K
Plachý
J
J
Wick
G
G
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D015704:CD4 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000502:physiology; D002645:Chickens; D009765:Obesity / Q000150:complications / Q000235:genetics / Q000662:veterinary*; D011201:Poultry Diseases / Q000209:etiology / Q000517:prevention & control*; D013967:Thyroiditis, Autoimmune / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens