[The role of the phosphoinositide signal system and phosphatidylethanolamine methylation in the development of long-term posttetanic potentiation in rats].
A long-term potentiation of the rat olfactory cortex slices induced by a high-frequency stimulation is followed by membrane phospholipid changes. Activation of the phosphoinositide metabolism and normalising of phosphatidylethanolamine methylation occurs within 60 min after tetanisation when the potentiation fades. The findings reveal a regulating role of the phospholipid signal system at different stages of the long-term potentiation.
Pavlinova
L I
LI
Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg.
Gerasimova
I A
IA
Mokrushin
A A
AA
D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D008745:Methylation; D008839:Microelectrodes; D009833:Olfactory Pathways / Q000502:physiology; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013997:Time Factors
D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D011950:Receptors, Cholinergic; D017470:Receptors, Glutamate
Rol' fosfoinozitidnoĭ signal'noĭ sistemy i metilirovaniia fosfatidilétanolamina v razvitii dlogovremennoĭ posttetanicheskoĭ potentsiatsii u krys.