Evaluation of non-linear and linear mathematical models for creatinine and glucose fitting in peritoneal dialysis.
Four non-linear and five linear models for predicting the creatinine dialysate/ plasma ratio (CRD/P) and the glucose dialysate/initial concentration ratio (GLD/D0) were evaluated in a group of 31 patients on peritoneal dialysis and subjected to the peritoneal equilibration test (PET 3.86%, 240'). PET results and classification were compared to obtain a definition of patient peritoneal transport characteristics. The monomolecular and rectangular hyperbola non-linear models, the Lineweaver-Burk, Hanes-Woolf and Dadone linear transformations were considered for the CRD/P fitting. A monoexponential and two-exponential decay plus the semilogarithmic transformations were considered for the GLD/ D0. These models are simple, accurate and functionally homogeneous. Further studies are advisable however on the individual peritoneal transport classification, since approximately 30% of the patients were in different categories for CRD/P and GLD/D0 and the fittings do not give better classification results.
Amici
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Nephrology and Dialysis Division, Regional Hospital, S. Maria dei Battuti, Treviso, Italy.
D000368:Aged; D000704:Analysis of Variance; D001692:Biological Transport; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000098:blood supply / Q000378:metabolism*
D001786:Blood Glucose; D003404:Creatinine; D005947:Glucose