Cisplatin microcrystals suspended in oil: pathological study of acute toxicity in mice.
The pathological changes brought about by the i.p. administration of a new dosage format, cisplatin microcrystals suspended in oil (CDDP-Oil), was examined in mice. CDDP-Oil decreased the absolute weight and the relative weight (organ weight/body weight) of the kidney, liver and spleen in the mice receiving the dosage form. However, the severity of the reduction of the organ weight in the CDDP-Oil administration groups was not different from that in the cisplatin aqueous solution (CDDP-Sol) administration groups. Histologically, severe degeneration and atrophy were recognized in the kidney, large intestine, small intestine, thymus, spleen, bone marrow and lymph nodes in the CDDP-Oil administration groups as well as CDDP-Sol administration groups. However, there were no additional changes in the macroscopic and microscopic findings in the CDDP-Oil groups. From these results, we concluded that this dosage form did not change the toxicity of cisplatin in terms of pathological effects.
Tsujimoto
H
H
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Sasaki
S
S
Osaki
K
K
Ohyama
T
T
Ohgaki
M
M
Imanishi
T
T
Yamazaki
J
J
Sakakura
C
C
Hagiwara
A
A
Takahashi
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013535:Suspensions
D000970:Antineoplastic Agents; D013535:Suspensions; D002945:Cisplatin