title: Technical determinants of success in catheter-directed thrombolysis for peripheral arterial occlusions.
abstract: Local intraarterial thrombolytic therapy restores blood flow to the ischemic limb by dissolving the occlusive thrombus and identifies culprit lesions for treatment by means of surgical and/or percutaneous procedures. The techniques used for administration of the thrombolytic agent, the drug used, and the criteria for termination of the therapy are all factors that can influence both technical success and speed of lysis. This article discusses these factors and their influence on thrombolytic success.
authors.affiliation: Harvard Medical School, Division of Cardiovascular and Interventional Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kandarpa
mesh_terms: D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000295:instrumentation; D007511:Ischemia / Q000188:drug therapy; D007866:Leg / Q000098:blood supply; D015912:Thrombolytic Therapy / Q000295:instrumentation*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents