title: Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei.
abstract: Two new flavano flavanone glycosides, diinsininol (1) and diinsinin (2), have been isolated from the rhizome of Sarcophyte piriei, together with one known flavanone glycoside, naringenin 5-glucoside. Their structures were elucidated on spectroscopic evidence as 5,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4beta-8; 2beta-O-7)-eriodietyol (1) and 5,7,3',4'-tetrahydroxyflavanyl 7-O-beta-glucosyl-(4beta-8;2beta-O-7)-naringenin (2), respectively. The compounds were tested for their ability to inhibit prostaglandin synthesis, with 1 and 2 giving IC50 values of 9.20 microM and 13.14 microM, respectively, and in the inhibition of platelet-activating-factor-induced exocytosis, IC50 values of 49 and 39 microM.
authors.affiliation: Division of Pharmacognosy, Biomedical Centre, Uppsala University, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Ogundaini
authors.forename: M
authors.initials: M
authors.lastname: Farah
authors.forename: P
authors.initials: P
authors.lastname: Perera
authors.forename: G
authors.initials: G
authors.lastname: Samuelsson
authors.forename: L
authors.initials: L
authors.lastname: Bohlin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D005089:Exocytosis / Q000187:drug effects; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D012998:Somalia; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044950:Flavanones; D005419:Flavonoids; D006027:Glycosides; D010972:Platelet Activating Factor; D011453:Prostaglandins; C100905:diinsinin; C100904:diinsininol