Successful twin pregnancy in homozygous beta-thalassemia after ovulation induction with growth hormone and gonadotropins.
OBJECTIVE
To describe infertility treatment and pregnancy outcome in a patient with transfusion-dependent beta-thalassemia major and hypopituitarism.


METHODS
Case report.


METHODS
University-affiliated infertility clinic.


METHODS
Twenty-four-year-old infertile patient with homozygous beta-thalassemia.


METHODS
Co-treatment with GH and gonadotropins.


RESULTS
Ovulation induction with clomiphene citrate or gonadotropins alone was unsuccessful. Combined treatment with hMG, hCG, and recombinant human GH followed by intrauterine insemination resulted in a viable twin pregnancy.


CONCLUSIONS
Human GH as an adjunct to hMG and hCG seems to be a sensible approach in the treatment of infertile homozygous beta-thalassemic patients among which very few pregnancies are reported.
Surbek
D
D
University Hospital, Basel, Switzerland.
Koller
A
A
Pavic
N
N
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use; D006720:Homozygote; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011248:Pregnancy Complications; D011272:Pregnancy, Multiple; D011994:Recombinant Proteins; D014427:Twins; D017086:beta-Thalassemia / Q000235:genetics* / Q000503:physiopathology
D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins; D008596:Menotropins; D013006:Growth Hormone