title: Synthesis and antimicrobial evaluation of 2 beta-chloromethyl-6 beta-carbamoylmethyl-penam-1,1-dioxide-3-carboxylic acid.
abstract: A new 2 beta-Chloromethyl-6 beta-carbamoylmethyl-penam-1,1-dioxide-3-carboxylic acid was synthesised and evaluated for its antimicrobial and beta-lactamase inhibitory activity. The compound was found to be inactive.
authors.affiliation: Glaxo Welcome SpA, Centro Ricerche, Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gaviraghi
authors.forename: A
authors.initials: A
authors.lastname: Perboni
authors.forename: B
authors.initials: B
authors.lastname: Tamburini
authors.forename: L
authors.initials: L
authors.lastname: Xerri
authors.forename: A
authors.initials: A
authors.lastname: Salvatori
authors.forename: G
authors.initials: G
authors.lastname: Spadoni
authors.forename: G
authors.initials: G
authors.lastname: Tarzia
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007769:Lactams; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C101710:2-chloromethyl-6-carbamoylmethylpenam-1,1-dioxide-3-carboxylic acid; D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004791:Enzyme Inhibitors; D007769:Lactams; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D019818:Clavulanic Acid; D000658:Amoxicillin