Zearalenone induces modifications of haematological and biochemical parameters in rats.
Zearalenone produced by the fungus Fusarium roseum causes important perturbations in the gestation cycle of the rat with hormonal disorders and infertility. In order to find out other eventual toxic effects, female rats were given intraperitoneally (i.p.) (1.5, 3 and 5 mg/kg) zearalenone in sterile olive oil. Forty-eight hours later, some blood parameters changed (hematocrit, MCV, the number of platelets and WBC) as well as some biochemical markers such as aminotransferases (ALT, AST), alkaline phosphatase (ALP), serum creatinine, bilirubin, indicating liver toxicity, and likely impairment of blood coagulation process.
Maaroufi
K
K
Laboratoire de Biochimie et de Toxicologie Moléculaire, Faculté de Médecine Dentaire, Tunisie, France.
Chekir
L
L
Creppy
E E
EE
Ellouz
F
F
Bacha
H
H
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D001800:Blood Specimen Collection; D002452:Cell Count / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007962:Leukocytes / Q000187:drug effects; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000637:Transaminases / Q000097:blood; D015025:Zearalenone / Q000008:administration & dosage / Q000633:toxicity*
D015415:Biomarkers; D004968:Estrogens, Non-Steroidal; D006454:Hemoglobins; D000069463:Olive Oil; D010938:Plant Oils; D015025:Zearalenone; D003404:Creatinine; D000637:Transaminases; D000469:Alkaline Phosphatase; D001663:Bilirubin