Possibility of thermosensitive magnetoliposomes as a new agent for electromagnetic induced hyperthermia.
This study examined a possibility of dextran magnetite (DM)-incorporated thermosensitive liposomes, namely thermosensitive magnetoliposomes (TMs), as a new hyperthermic agent. The temperatures of TM suspensions and cancer tumors injected with TM suspensions were efficiently elevated up to 42 degrees C by electromagnetic induced heating at a frequency of 500 kHz under both in vitro and in vivo conditions. Thus, a possibility of TMs for selective hyperthermia was demonstrated. The temperature rises obtained at various concentrations of TMs suggest that approximately 15 mg Fe/cm3 tumor volume is adequate as a therapeutic dose of TMs for efficient selective hyperthermia.
Masuko
Y
Y
Second Department of Surgery, Toyama Medical and Pharmaceutical University, Japan.
Tazawa
K
K
Viroonchatapan
E
E
Takemori
S
S
Shimizu
T
T
Fujimaki
M
M
Nagae
H
H
Sato
H
H
Horikoshi
I
I
D000818:Animals; D006614:Hindlimb; D006979:Hyperthermia, Induced / Q000379:methods*; D007505:Iron-Dextran Complex; D008081:Liposomes; D009374:Neoplasms, Experimental / Q000628:therapy*; D051381:Rats
D008081:Liposomes; D007505:Iron-Dextran Complex