title: The molecular mechanism of platelet adhesion.
abstract: One of the most primitive of host-defence mechanisms is haemostasis, the ability to control blood loss. In response to vascular trauma, platelets rapidly adhere to the exposed subendothelial matrix, a process that ultimately results in the sealing of the vessel by a plug of platelets stabilised by fibrin. Paradoxically, it is the same cascade of events that leads to thrombosis and vessel occlusion, resulting in heart attack and stroke. The molecular events involved in platelet adhesion have therefore been the subject of intense investigation. In all but the largest blood vessels, the initial contact adhesion of platelets is mediated by subendothelial matrix bound von Willebrand Factor (vWF) and a specific vWF receptor on platelets, the glycoprotein (GP) Ib-V-IX complex. Our understanding of this process arose from analysis of two congenital bleeding disorders, von Willebrand's disease and the Bernard-Soulier syndrome, in which vWF or the GP Ib-V-IX, respectively, are either absent or dysfunctional. This overview discusses our current molecular understanding of platelet adhesion and how engagement of vWF by the GP Ib-V-IX complex on platelets initiates the subsequent events in platelet activation leading to either haemostasis or thrombosis.
authors.affiliation: Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Vic.
authors.forename: M C
authors.initials: MC
authors.lastname: Berndt
authors.forename: C M
authors.initials: CM
authors.lastname: Ward
authors.forename: M
authors.initials: M
authors.lastname: De Luca
authors.forename: D A
authors.initials: DA
authors.lastname: Facey
authors.forename: P A
authors.initials: PA
authors.lastname: Castaldi
authors.forename: S J
authors.initials: SJ
authors.lastname: Harris
authors.forename: R K
authors.initials: RK
authors.lastname: Andrews
mesh_terms: D000818:Animals; D001606:Bernard-Soulier Syndrome / Q000235:genetics; D006487:Hemostasis / Q000235:genetics*; D006801:Humans; D015539:Platelet Activation / Q000235:genetics; D010973:Platelet Adhesiveness / Q000235:genetics*; D010974:Platelet Aggregation / Q000235:genetics*; D014842:von Willebrand Diseases / Q000235:genetics