Epidermal growth factor receptor expression: is it the same in normal and malignant endometria?
Epidermal growth factor was investigated in normal and malignant tissues in order to detect possible differences in its expression. We used immunohistochemical techniques that employ murine monoclonal antibody 528. Thirty-nine patients (12 with normal endometria and 27 with endometrial adenocarcinomas) were examined. Epidermal growth factor receptor was seen in all normal uteri and in 27 uteri with adenocarcinoma. It was absent in 11 patients with cancer. No correlation was found between the intensity of immunohistochemical staining and histologic grade, depth of myometrial invasion and clinical stage.
Zarcone
R
R
Department of Obstetrics and Gynecology, Second University of Naples.
Bellini
P
P
Cardone
G
G
Vicinanza
G
G
Cardone
A
A
D000230:Adenocarcinoma / Q000737:chemistry*; D000328:Adult; D000911:Antibodies, Monoclonal; D016889:Endometrial Neoplasms / Q000737:chemistry*; D004717:Endometrium / Q000737:chemistry*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D017154:Stromal Cells / Q000737:chemistry
D000911:Antibodies, Monoclonal; D066246:ErbB Receptors