title: Interaction between bovine collagen and glycolic acid peeling: a proposal of a new protocol.
abstract: For the past 10 years the alfa-hydroxyacids and the bovine collagen injection have been used for peeling and the correction of multiple skin diseases. Until now, such progressive achievement has occurred in separate parallels just like the indications that have been held distinct. However, the studies carried out in order to clarify the mechanical action of the two substances have shown a common and fundamental denominator: the stimulation of synthesis of the new collagen in the patient's skin. On the basis of these results and the existence of common clinical indications of the use of glycolic acid and collagen, the authors have worked out a protocol involving a combined and contemporary application in progressive steps. They developed the rationales of such protocol and analyzed the results of its application on a number of carefully selected patients for a clinical comparison and on a sample of rats for a histological comparison. They have concluded that the contemporary use of glycolic acid and bovine collagen is a simple and safe method whose synergy action leads to more intense and long-lasting effects than the ones observed in the isolated application of the two substances. The authors have also obtained interesting and significant histological results.
authors.forename: G
authors.initials: G
authors.lastname: Sito
authors.forename: L
authors.initials: L
authors.lastname: Sorrentino
mesh_terms: D000328:Adult; D000818:Animals; D002615:Chemexfoliation; D002985:Clinical Protocols; D003094:Collagen / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006016:Glycolates / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006016:Glycolates; C031149:glycolic acid; D003094:Collagen