title: [Scintigraphy using leukocytes marked with 99m-Tc-HMPAO in Crohn's disease].
abstract: 99mTc-HMPAO leukocyte scintigraphy was prospectively studied in 20 patients with Crohn's Disease and was compared with radio-endoscopy and with disease activity index (Crohn's Disease Activity Index, ESR, C-reactive protein). Disease localization as defined by the scan was well correlated with those visualized at endoscopy or radiography (rs = 0.90 - p = 0.0001). A scan score was calculated by evaluating uptake of the tracer in 6 bowel segments with lumbar bone marrow activity, correlation with endoscopic score was strong (rs = 0.96 - p < 0.0001). Scan score was well correlated with the Crohn's Disease Activity Index (rs = 0.63 - p = 0.0026), but no correlation was found between ESR, C-reactive protein and scan score. In four patients with ileal localization, scintigraphy was helpful to separate inflammatory from scared stenosis. Scintigraphy with 99mTc-HMPAO appeared to be useful in evaluation of Crohn's Disease activity, and for the diagnosis of complications as stenosis.
authors.affiliation: Service de Médecine Interne, Hôpital Cochin, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Dhôte
authors.forename: E
authors.initials: E
authors.lastname: Beades
authors.forename: T
authors.initials: T
authors.lastname: Le Dinh
authors.forename: C
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: J Y
authors.initials: JY
authors.lastname: Devaux
authors.forename: B
authors.initials: B
authors.lastname: Richard
authors.forename: B
authors.initials: B
authors.lastname: Christoforov
mesh_terms: D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003424:Crohn Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D002097:C-Reactive Protein
vernacular_title: Scintigraphie aux leucocytes marqués par l'HMPAO 99mTc au cours de la maladie de Crohn.