A genetic analysis of common disease data.
Simulated common disease data have been analyzed to identify a model of disease expression that involves the complex interaction of quantitative traits controlled by major genes and an environmental factor. Correlation and multiple regression analyses in conjunction with quantitative sib-pair linkage analyses revealed a portion of the model involved.
Cantor
R M
RM
Division of Medical Genetics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
D003198:Computer Simulation; D004782:Environmental Health; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D010641:Phenotype; D012044:Regression Analysis