title: Prospective evaluation of pharmacokinetic model-controlled infusion of propofol in adult patients.
abstract: We have tested prospectively the algorithm of White and Kenny for pharmacokinetic model-controlled infusion of propofol in 40 healthy Oriental adults. Anaesthesia consisted of a target-controlled infusion of propofol, 70% nitrous oxide and an infusion of alfentanil. For the first 20 patients studied, median performance error was -5%, median absolute performance error 19%, divergence -9% and wobble 6%. The model was revised to minimize the prediction error of the variable set and tested prospectively in another 20 patients. There was a deterioration in performance of the revised model. Performance statistics for the original model in all 40 patients were: median performance error 2% (range -34 to 69%), median absolute performance error 21% (6-69%), divergence -17% (-92 to 49%) and wobble 7% (2-34%). The algorithm was found to perform adequately in our Oriental patient population.
authors.affiliation: Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong.
authors.forename: T G
authors.initials: TG
authors.lastname: Short
authors.forename: T A
authors.initials: TA
authors.lastname: Lim
authors.forename: Y H
authors.initials: YH
authors.lastname: Tam
mesh_terms: D000328:Adult; D000465:Algorithms; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood; D044466:Asian People; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood; D011446:Prospective Studies
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol