title: Antipyretic activity of Nelumbo nucifera rhizome extract.
abstract: Antipyretic activity of methanolic extract of rhizome of N. nucifera was studied on normal body temperature and yeast induced pyrexia in rats. Yeast suspension (10 ml/kg, s.c.) increased rectal temperature after 19 hr of administration. The extract, in doses of 200, 300 or 400 mg/kg (po) produced significant dose dependent lowering of normal body temperature and yeast provoked elevation of body temperature in rats. The effect produced was comparable with the standard antipyretic drug, paracetamol (150 mg/kg, i.p.).
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Mukherjee
authors.forename: J
authors.initials: J
authors.lastname: Das
authors.forename: K
authors.initials: K
authors.lastname: Saha
authors.forename: S N
authors.initials: SN
authors.lastname: Giri
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts