Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins.
Morgan
R A
RA
Walker
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy*; D019264:Adoptive Transfer; D016375:Antisense Elements (Genetics) / Q000235:genetics / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002985:Clinical Protocols; D004200:Diseases in Twins / Q000628:therapy*; D015694:Gene Products, rev / Q000235:genetics; D018014:Gene Transfer Techniques; D015757:Genes, rev; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000235:genetics; D016325:HIV Long Terminal Repeat / Q000235:genetics*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008979:Moloney murine leukemia virus / Q000235:genetics; D014430:Twins, Monozygotic; D054321:rev Gene Products, Human Immunodeficiency Virus
D016375:Antisense Elements (Genetics); D015694:Gene Products, rev; D054321:rev Gene Products, Human Immunodeficiency Virus