Somatostatin and the patch/matrix compartments of the rat caudate-putamen.
In the caudate-putamen of the rat, two subpopulations of medium aspiny neurons exist that contain somatostatin. The first subpopulation contains somatostatin 14, somatostatin 28, and somatostatin 28(1-12). The other subpopulation contains only somatostatin 28. To examine the relationship between somatostatin-containing neurons and the patch/matrix compartments, a series of double-labelling experiments using antisera directed against different somatostatin peptides and calbindin were used. Sections stained in this manner were examined with the aid of a confocal microscope. The results of these experiments indicate that somatostatin 28(1-12)-containing neurons may play a role in matrix integration, with some input directed from the patch compartment. In addition, somatostatin 28-containing neurons are more numerous in the patch compartment than somatostatin 28(1-12)-containing neurons, suggesting a possible role for these neurons in patch integration.
Rushlow
W
W
Department of Anatomy, University of Western Ontario, London, Canada.
Naus
C C
CC
Flumerfelt
B A
BA
D000818:Animals; D064026:Calbindins; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000737:chemistry*; D005260:Female; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D018613:Microscopy, Confocal; D009419:Nerve Tissue Proteins / Q000032:analysis; D009474:Neurons / Q000737:chemistry; D011699:Putamen / Q000033:anatomy & histology / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology*; D064030:S100 Calcium Binding Protein G / Q000032:analysis; D013004:Somatostatin / Q000032:analysis*
D064026:Calbindins; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G; D013004:Somatostatin