Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei.
Two new flavano flavanone glycosides, diinsininol (1) and diinsinin (2), have been isolated from the rhizome of Sarcophyte piriei, together with one known flavanone glycoside, naringenin 5-glucoside. Their structures were elucidated on spectroscopic evidence as 5,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4beta-8; 2beta-O-7)-eriodietyol (1) and 5,7,3',4'-tetrahydroxyflavanyl 7-O-beta-glucosyl-(4beta-8;2beta-O-7)-naringenin (2), respectively. The compounds were tested for their ability to inhibit prostaglandin synthesis, with 1 and 2 giving IC50 values of 9.20 microM and 13.14 microM, respectively, and in the inhibition of platelet-activating-factor-induced exocytosis, IC50 values of 49 and 39 microM.
Ogundaini
A
A
Division of Pharmacognosy, Biomedical Centre, Uppsala University, Sweden.
Farah
M
M
Perera
P
P
Samuelsson
G
G
Bohlin
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D005089:Exocytosis / Q000187:drug effects; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D012998:Somalia; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000894:Anti-Inflammatory Agents, Non-Steroidal; D044950:Flavanones; D005419:Flavonoids; D006027:Glycosides; D010972:Platelet Activating Factor; D011453:Prostaglandins; C100905:diinsinin; C100904:diinsininol