title: Improved analogs and novel delivery systems for somatostatin octapeptides.
abstract: Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.
authors.affiliation: Biomeasure Inc., Milford, MA 01757-3650, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Moreau
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: J Z
authors.initials: JZ
authors.lastname: Dong
authors.forename: F
authors.initials: F
authors.lastname: Ignatious
authors.forename: S
authors.initials: S
authors.lastname: Jackson
authors.forename: S C
authors.initials: SC
authors.lastname: Moreau
authors.forename: B A
authors.initials: BA
authors.lastname: Morgan
authors.forename: F
authors.initials: F
authors.lastname: Touraud
authors.forename: J E
authors.initials: JE
authors.lastname: Taylor
authors.forename: B
authors.initials: B
authors.lastname: Tissier
authors.forename: M
authors.initials: M
authors.lastname: Pellet
authors.forename: W
authors.initials: W
authors.lastname: Murphy
authors.forename: T
authors.initials: T
authors.lastname: Davis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002214:Capsules; D003692:Delayed-Action Preparations; D015198:Designer Drugs; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D015198:Designer Drugs; D013004:Somatostatin