title: Plasma PIVKA proteins in rabbits given warfarin.
abstract: The presence of partially carboxylated forms of the vitamin K dependent coagulation factors (PIVKA) was evaluated in the plasma of rabbits treated with warfarin. Excess antigen over activity as measured in rabbit specific assays was taken as evidence for PIVKA. Our data confirm a previous report of the absence of plasma PIVKA prothrombin. In contrast, plasma PIVKA factors VII, IX, and X were demonstrable. A striking excess of plasma factor IX antigen over activity was measured and a large fraction of the factor IX antigen persisted in the plasma after its adsorption with barium citrate.
authors.affiliation: Department of Medicine, University of California, San Diego, USA.
authors.forename: A
authors.initials: A
authors.lastname: Zivelin
authors.forename: L V
authors.initials: LV
authors.lastname: Rao
authors.forename: S I
authors.initials: SI
authors.lastname: Rapaport
mesh_terms: D000818:Animals; D015415:Biomarkers; D005164:Factor IX / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D011516:Prothrombin / Q000378:metabolism*; D011817:Rabbits; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D014859:Warfarin; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X