title: Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis.
abstract: BACKGROUND
  Underestimation of allergic bronchopulmonary aspergillosis (ABPA) prevalence in the cystic fibrosis (CF) population is suspected due to nonuniform diagnostic criteria, nonspecific signs and symptoms, assessment during asymptomatic intervals, and physician nonaggressiveness in making the diagnosis.
  
  
  OBJECTIVE
  To define the prevalence of ABPA in adult patients with CF, as the increased duration of bronchiectasis may increase the probability of Aspergillus fumigatus (Af) colonization. We also sought to determine whether atopy increases the prevalence of ABPA in adults with CF.
  
  
  METHODS
  We examined a cross-sectional population of adult patients with CF at the University of Washington for 1 year.
  
  
  RESULTS
  Information was collected on 53 of 65 (82%) patients. Fifteen of 51 (29%) had an immediate skin test reaction to Af, and 30 of 51 (59%) had at least one positive skin test. Increased total serum IgE (>450 IU/mL) was present in 0 of 53; increased IgE-Af and IgG-Af were found in 12 of 53 (23%) and 9 of 53 (17%), respectively; 24 of 53 (45%) had Af-precipitins. Peripheral blood eosinophilia was present in one patient. Eight of 49 (16%) patients' sputum cultures grew Af. ABPA-CB (ABPA-central bronchiectasis) was present in one patient and ABPA-S (ABPA-seropositive) in no patients. Atopy was present in 20 of 51 (39%).
  
  
  CONCLUSIONS
  There was a low prevalence of ABPA in the adult CF population despite frequent immunologic responses to Af. The prevalence of ABPA was too small to determine an association with atopy.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle 98195, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Becker
authors.forename: W
authors.initials: W
authors.lastname: Burke
authors.forename: G
authors.initials: G
authors.lastname: McDonald
authors.forename: P A
authors.initials: PA
authors.lastname: Greenberger
authors.forename: W R
authors.initials: WR
authors.lastname: Henderson
authors.forename: M L
authors.initials: ML
authors.lastname: Aitken
mesh_terms: D000328:Adult; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications* / Q000175:diagnosis; D001232:Aspergillus fumigatus / Q000276:immunology; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications* / Q000175:diagnosis; D007073:Immunoglobulin E / Q000032:analysis; D007428:Intradermal Tests; D008297:Male; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E