title: Retiform haemangioendothelioma.
abstract: A case of retiform haemangioendothelioma (RH), a recently described rare cutaneous low-grade angiosarcoma, is presented. A 75-year-old female had a 3.5 cm cutaneous nodule in her right lower thigh with 10 year preoperative duration. Microscopically, the dermis and subcutis contained a diffuse and infiltrative neoplasm which was characterized by long arborizing blood vessels arranged in a retiform pattern lined by cuboidal and flattened cells, occasional hobnail appearance of endothelial cells, and a prominent small lymphocytic infiltrate. Small solid areas were also found. Neither significant cellular atypia nor mitotic activity was observed. Immunohistochemically, the tumour cells reacted with endothelial markers (CD31, CD34, factor-VIII-related antigen) and bound Ulex europaeus agglutinin 1. There was no pericytic component within the tumour. The tumour was diploid by flow cytometry. The patient had a local recurrence 27 months after the excision. These findings support the view that RH is a low-grade angiosarcoma and indicate that RH must be distinguished from conventional angiosarcoma.
authors.affiliation: Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
authors.forename: F
authors.initials: F
authors.lastname: Masui
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: E
authors.initials: E
authors.lastname: Ishikawa
authors.forename: S
authors.initials: S
authors.lastname: Ushigome
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006390:Hemangioendothelioma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D037102:Lectins / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D037121:Plant Lectins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; D015815:Cell Adhesion Molecules; D037102:Lectins; D037121:Plant Lectins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C036850:Ulex europaeus lectins; D014841:von Willebrand Factor