[The treatment of cryptosporidiosis in AIDS patients using paromomycin].
The authors treated with paromomycin 25 patients, with AIDS and cryptosporidiosis. The drug was given orally in a doses of 500 mg qid, for a period of 14 days. Tolerance was good, with just two cases of mild side-effects. Clinical improvement was obtained in 19 (76%) patients. Parasitological cure, however, occurred only in a low percentage (25%). In some cases where initial success was observed, recrudescence occurred after some weeks or few months, but with retreatment again clinical improvement was obtained. Even if it does not lead to frequent parasite eradication, the good clinical results and tolerance permit us to consider paromomycin one of the few drugs effective for the treatment of cryptosporidial diarrhea in AIDS patients. Studies with maintainance therapy are indicated.
Stefani
H N
HN
Serviço de Doenças Transmissíveis, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, São Paulo, Brasil.
Levi
G C
GC
Amato Neto
V
V
Braz
L M
LM
Azevedo
H D
HD
Pôssa
T A
TA
Silva
N F
NF
de Mendonça
J S
JS
Fernandes
A O
AO
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy*; D003967:Diarrhea / Q000188:drug therapy; D004341:Drug Evaluation; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D010303:Paromomycin / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence
D000900:Anti-Bacterial Agents; D010303:Paromomycin
Tratamento da criptosporidíase em pacientes com AIDS, por meio da paromomicina.