Renal functional reserve in kidney donors assessed in different settings using scintigraphy.
Glomerular filtration rate (GFR) was measured in 9 voluntary male kidney donors by scintigraphy. In the basal state, the mean GFR was 96.1 +/- 22 ml/min/1.73 m2. Four weeks after donor nephrectomy, the GFR of the remaining kidney had increased by 22.8 +/- 20.7% (p < 0.05). A protein meal given at this time failed to significantly augment the GFR. The GFR of the grafted kidney increased by 59.7 +/- 24.4% after 6 months (p < 0.01). Renal functional reserve was thus demonstrated in the remaining kidney and the allograft, though a further reserve could not be elicited in the remaining kidney.
George
J
J
Department of Nephrology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
John
G T
GT
Oommen
R
R
Jacob
S
S
Jacob
C K
CK
Shastry
J C
JC
D000328:Adult; D004044:Dietary Proteins / Q000378:metabolism; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007677:Kidney Function Tests / Q000379:methods*; D016030:Kidney Transplantation / Q000502:physiology; D019520:Living Donors; D008297:Male; D009392:Nephrectomy; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate
D004044:Dietary Proteins; D016284:Technetium Tc 99m Pentetate