HIV and pulmonary immune responses.
The lung is a central organ in human immunodeficiency virus (HIV)-induced pathophysiology, becoming infected during the asymptomatic period of the disease. The presence of HIV elicits a discrete virus-specific cytotoxic T lymphocyte (CTL)-mediated immune response in the pulmonary microenvironment. Here, Carlo Agostini and colleagues provide a framework for understanding the mechanisms underlying the spread of the retrovirus and the consequent progression of disease in patients with AIDS-associated lung involvement.
Agostini
C
C
Dept of Clinical and Experimental Medicine, Padua University School of Medicine, Italy.
Zambello
R
R
Trentin
L
L
Semenzato
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D006678:HIV / Q000276:immunology* / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007111:Immunity, Cellular; D008168:Lung / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D017563:Lung Diseases, Interstitial / Q000209:etiology / Q000473:pathology