A novel leptin receptor isoform in rat.
Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Ob-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region without homology to other Ob-R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob-Ra and Ob-Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob-R gene family.
Wang
M Y
MY
Gifford Laboratories for Diabetes Research, Dallas, TX 75235, USA.
Zhou
Y T
YT
Newgard
C B
CB
Unger
R H
RH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine / Q000235:genetics*; D054411:Receptors, Leptin; D017386:Sequence Homology, Amino Acid
D002352:Carrier Proteins; D018076:DNA, Complementary; C515448:LEPR protein, human; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D054411:Receptors, Leptin; C515447:leptin receptor, mouse