[Adverse effects of ketoprofen after intrauterine exposure. Value of plasma determination].
BACKGROUND
Prostaglandin synthetase inhibitors have been used to prevent the onset of premature labor. But a small number of newborn infants have been reported with premature closure of the ductus arteriosus, pulmonary hypertension and/or oliguria.


METHODS
Eleven neonates from seven pregnancies were admitted because they suffered from adverse effects of ketoprofen given to their mothers before delivery. The plasma ketoprofen level was measured in 6 of the neonates.


RESULTS
Ten of the 11 neonates had renal dysfunction which was lethal in three; two of the 11 developed cardiopulmonary complications, lethal in one. The ketoprofen concentration in plasma was high in the first few hours of life in three patients.


CONCLUSIONS
In the absence of precise risk factors for prognosis, repeated drug measurements in the maternal plasma before delivery and in their babies after birth could be a predictive factor.
Llanas
B
B
Service de réanimation néonatale et infantile, CHRU de Bordeaux, France.
Cavert
M H
MH
Apere
H
H
Demarquez
J L
JL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007660:Ketoprofen / Q000009:adverse effects* / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008431:Maternal-Fetal Exchange; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015149:Tocolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015149:Tocolytic Agents; D007660:Ketoprofen
Les effets secondaires du kétoprofène après exposition intra-utérine. Intérêt du dosage plasmatique.