Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus.
Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 microgram/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.
Sendl
A
A
Shaman Pharmaceuticals, South San Francisco, California 94080, USA.
Chen
J L
JL
Jolad
S D
SD
Stoddart
C
C
Rozhon
E
E
Kernan
M
M
Nanakorn
W
W
Balick
M
M
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005591:Chemical Fractionation; D003587:Cytomegalovirus / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal
D000998:Antiviral Agents; D009285:Naphthoquinones; D010936:Plant Extracts