title: Novel monoacetoneglucose derivatives with calcium antagonist activity.
abstract: Ethers and thioethers of monosaccharides have been synthesised which show potent toxicity to mouse (LD50 > or = 4 g.kg-1 O.W. and 0.2 to 1.5 g.kg-1 I.P.W.). A study of calcium antagonist activity for the full series of compounds indicated that the activity was similar for both O- and S- ethers and maximum activities were observed for monoacetoneglucose ethers possessing carbon chain close to 8 carbons.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire, Faculté des Sciences-Université de Picardie Jules Verne, Amiens, France.
authors.forename: T
authors.initials: T
authors.lastname: Bécaert
authors.forename: P
authors.initials: P
authors.lastname: Vanlemmens
authors.forename: P
authors.initials: P
authors.lastname: Villa
authors.forename: A
authors.initials: A
authors.lastname: Lahyani
authors.forename: J
authors.initials: J
authors.lastname: Lehouelleur
authors.forename: D
authors.initials: D
authors.lastname: Postel
authors.forename: G
authors.initials: G
authors.lastname: Ronco
authors.forename: G
authors.initials: G
authors.lastname: Brulé
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004386:Duodenum / Q000187:drug effects; D005947:Glucose / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats
chemical_list: D002121:Calcium Channel Blockers; D005947:Glucose