Second temporal remission in a malignant glioma with trofosfamide and etoposide: a case report.
A case of a malignant childhood glioma is reported with tumor-progression after surgery and radiotherapy during chemotherapy with cisplatinum, vincristine and CCNU, that responded temporally to oral treatment with VP16 and trofosfamide. A Phase II study with this combination is suggested.
Wolff
J E
JE
Department of Pediatric Oncology, University of Münster, FRG.
Boos
J
J
Krähling
K H
KH
Jürgens
H
H
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D011859:Radiography
D018906:Antineoplastic Agents, Alkylating; D005047:Etoposide; D003520:Cyclophosphamide; C003726:trofosfamide