IL-4 and IFN-gamma level in blood serum of children with food allergy.
The aim of the study was an estimation of IL-4 and IFN-gamma lymphokines in children with food allergy symptoms. In 72 children with food allergy and 8 children with no allergy, sIgE and IgG levels to aliments in the blood serum were determined using the Visagnost Tosse Diagnostika method and IL-4 and IFN-gamma cytokines using the Elisa Genzyme method. The presence of specific IgE to one or several food allergens was found in children with food allergy while the average level of IL-4 was 113.2 pg/ml and IFN-gamma = 633.75 pg/ml, and no child had specific IgE to food in the control group and the IL-4 level was 43.1 pg/ml and IFN-gamma = 180.0 pg/ml. Il-4 and IFN-gamma levels were analysed with regard to the clinical type of the disease. In the blood serum of children with food allergy the IL-4 level was twice as high and the IFN-gamma level was four times as high as in the control group. The clinical type of the disease had no influence on the level of IL-4 and IFN-gamma. Delayed reactions are of fundamental significance in food allergy.
Hofman
T
T
Allergology Center, Poznań.
D005512:Food Hypersensitivity / Q000097:blood*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*
D015847:Interleukin-4; D007371:Interferon-gamma