title: Types of methicillin-resistant Staphylococcus aureus associated with high mortality in patients with bacteremia.
abstract: Forty-seven strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from 47 patients with bacteremia were analyzed by chromosomal DNA digestion pattern using pulsed-field gel electrophoresis and evaluated for serological coagulase type, enterotoxin type, and toxic shock syndrome toxin-1 production. The mortality rate was significantly higher in the older patients (> or = 51 years of age) than in the younger patients (< or = 50 years of age) (50% vs. 4%, p = 0.0007). Methicillin-resistant Staphylococcus aureus strains of serological coagulase type II were more likely to be associated with mortality in older patients than were strains of the other types (p = 0.037).
authors.affiliation: Department of Clinical Laboratory Medicine, Nagoya University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nada
authors.forename: S
authors.initials: S
authors.lastname: Ichiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Iinuma
authors.forename: K
authors.initials: K
authors.lastname: Inuzuka
authors.forename: H
authors.initials: H
authors.lastname: Washida
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Shimokata
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Nakashima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality*; D001427:Bacterial Toxins; D002648:Child; D002675:Child, Preschool; D003030:Coagulase / Q000378:metabolism; D004768:Enterotoxins / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D015183:Restriction Mapping; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000401:mortality*; D013211:Staphylococcus aureus / Q000145:classification* / Q000378:metabolism; D018089:Superantigens
chemical_list: D001427:Bacterial Toxins; D003030:Coagulase; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C034959:enterotoxin C, staphylococcal