Evidence for a phosphorylation site in cytomegalovirus glycoprotein gB.
As part of our vaccine program, we have purified a recombinant form of human cytomegalovirus glycoprotein B that is able to induce high titers of virus-neutralizing antibodies. The isolated protein was found to be phosphorylated at a serine residue in position -7 from the C terminus of the protein. The corresponding synthetic peptide, HLKDSDEEENV, was an efficient in vitro substrate of casein kinase II.
Norais
N
N
Chiron Corporation, Emeryville, California 94608, USA.
Hall
J A
JA
Gross
L
L
Tang
D
D
Kaur
S
S
Chamberlain
S H
SH
Burke
R L
RL
Marcus
F
F
D000595:Amino Acid Sequence; D003587:Cytomegalovirus / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*
D011994:Recombinant Proteins; D014759:Viral Envelope Proteins