Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization.
Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17q25-qter band (17q25.2-q25.3), with GAA distal to TK1. They were also shown to be, respectively, distal and proximal to an anonymous cosmid (cK17.71) previously mapped to this region.
Kuo
W L
WL
Division of Molecular Cytometry, Department of Laboratory Medicine, University of California, San Francisco, 94143, USA.
Hirschhorn
R
R
Huie
M L
ML
Hirschhorn
K
K
D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005959:Glucosidases / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D013937:Thymidine Kinase / Q000235:genetics*
D013937:Thymidine Kinase; D005959:Glucosidases