title: Transfusion-related acute lung injury (TRALI) after fresh frozen plasma in a patient with coagulopathy.
abstract: BACKGROUND
  Transfusion-related acute long injury (TRALI) is due to specific antigen-antibody reaction involving the donor's leucocyte or granulocyte antibodies towards the recipient's antigens. Aggregation in small pulmonary vessels occurs, leading to derangement of permeability.
  
  
  METHODS
  TRALI after transfusion of four units of fresh frozen plasma (FFP) for factor V deficiency prior to elective cholecystectomy is presented. Within a few minutes after the third unit of FFP a florid pulmonary oedema developed. Hypotension and hypoxia with SpO2 83-87% at FiO2 1.0 followed. Prompt monitoring of central haemodynamics revealed a normal cardiac index without pulmonary hypertension. The operation was then conducted as planned. The bilateral pulmonary oedema resolved after 72 hours with ventilatory support. The patient recovered without complications. When tested postoperatively, the second unit of FFP contained granulocyte antibodies and the third unit contained HLA antibodies. The crossmatch of the patient's granulocytes and lymphocytes towards the two donors of the two units of FFP was positive.
  
  
  CONCLUSIONS
  When TRALI is suspected the donor blood has to be tested against the recipient. Ventilatory support of the patient is continued until adequate oxygenation is reached.
authors.affiliation: Department of Anaesthesia, Helsinki University Central Hospital, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Lindgren
authors.forename: A
authors.initials: A
authors.lastname: Yli-Hankala
authors.forename: L
authors.initials: L
authors.lastname: Halme
authors.forename: S
authors.initials: S
authors.lastname: Koskimies
authors.forename: R
authors.initials: R
authors.lastname: Orko
mesh_terms: D000208:Acute Disease; D000937:Antigen-Antibody Reactions; D005166:Factor V Deficiency / Q000628:therapy*; D006098:Granulocytes / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011654:Pulmonary Edema / Q000209:etiology*; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens