Toxicological profile of aureofungin: a potent plant antifungal antibiotic.
Aureofungin is a heptaene type of antifungal antibiotic used for controlling plant fungal infections and diseases, during pre and post harvesting period of various crops. Acute and subacute oral toxicity of aureofungin in rats was studied along with haematological, urine analysis and other biochemical parameters related to liver and kidney organ functions. The results of these studies indicate mild toxic symptoms at higher doses which were reversible following its withdrawal.
Dhuley
J N
JN
Department of Pharmacology and Toxicology, Hindustan Antibiotics Ltd, Pimpri, Pune, India.
Shanbhag
V
V
Raman
P H
PH
Mujumdar
A M
AM
Naik
S R
SR
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D011090:Polyenes / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D012449:Safety
D000935:Antifungal Agents; D011090:Polyenes; C034048:aureofungin