title: Papillary thyroid carcinoma metastasizing to the sphenoid-ethmoid sinuses and skull base.
abstract: Metastatic papillary carcinoma to the sinuses and skull base is a rare occurrence. A case report of aggressive papillary carcinoma is reported. The tumor contained areas of insular and anaplastic degeneration with strong positive staining for p53 oncogene. Management included primary surgery, administration of radioactive iodine, and external beam radiation.
authors.affiliation: Department of Otolaryngology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Freeman
authors.forename: A
authors.initials: A
authors.lastname: Gershon
authors.forename: P G
authors.initials: PG
authors.lastname: Liavaag
authors.forename: P G
authors.initials: PG
authors.lastname: Walfish
mesh_terms: D002291:Carcinoma, Papillary / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D012888:Skull Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D007457:Iodine Radioisotopes; D016159:Tumor Suppressor Protein p53