title: Mediastinal infusion of epirubicin and 5-fluorouracil. A complication of totally implantable central venous systems. Report of a case.
abstract: Perforation of the wall of the superior vena cava by a central venous catheter is reported. The resultant inadvertent infusion of 5-fluorouracil and epirubicin caused a severe acute inflammatory reaction in the right-lobe bronchus, mediastinal infiltration and pleural and pericardial effusions. The patient recovered but has residual mild oesophageal dysfunction.
authors.affiliation: Department of Internal Medicine-Oncology, Hotel-Dieu, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodier
authors.forename: L
authors.initials: L
authors.lastname: Malbec
authors.forename: E P
authors.initials: EP
authors.lastname: Lauraine
authors.forename: L
authors.initials: L
authors.lastname: Batel-Copel
authors.forename: A
authors.initials: A
authors.lastname: Bernadou
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D015251:Epirubicin / Q000008:administration & dosage; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D007262:Infusions, Intravenous; D008297:Male; D008482:Mediastinum; D014683:Vena Cava, Superior / Q000293:injuries*
chemical_list: D015251:Epirubicin; D005472:Fluorouracil