title: Production of methyl 3-oxoartemisinate from methyl artemisinate by suspension cell culture of Mentha piperita.
abstract: Methyl artemisinate was fed to the suspension cell culture of Mentha piperita. The biotransformation product was isolated and identified as a novel compound, methyl 3-oxoartemisinate. The Mentha cells were apparently capable of extensively oxidizing at the allylic C-3 position, to give rise to an oxo group. The conversion of the fed methyl ester of the acid reached a maximum in 48 h with 5.5% conversion. The physicochemical data of the oxo compound are presented.
authors.forename: S U
authors.initials: SU
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Kwon
mesh_terms: D000179:Acrylates / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D037621:Artemisinins; D002478:Cells, Cultured; D046508:Culture Techniques / Q000379:methods; D019684:Magnoliopsida / Q000166:cytology / Q000378:metabolism*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000179:Acrylates; D037621:Artemisinins; D009281:Naphthalenes; C102769:methyl 3-oxoartemisinate; C102770:methyl artemisinate