title: Soluble receptors for tumor necrosis factor are markers for clinical course but not for major metabolic changes in human immunodeficiency virus infection.
abstract: Tumor necrosis factor alpha (TNF) is a potential mediator of the metabolic changes in human immunodeficiency virus type 1 (HIV) infection. Soluble TNF receptor types I and II (sTNFR-I and -II) presumably reflect TNF activity. To examine the relationship between s TNFRs and host metabolism, resting energy expenditure (REE), body composition, and transferrin, albumin, triglyceride, retinol-binding protein, and sTNFR concentrations were measured in 12 asymptomatic and 18 symptomatic HIV-infected male subjects and 15 male control subjects. sTNFRs were increased in parallel with disease severity. REE was elevated approximately 8% in HIV-infected subjects (P = .005). REE correlated positively with fat free mass (FFM) and the presence of HIV infection, but not with sTNFRs. Inverse correlations existed between sTNFR-I or -II and albumin concentration (r = -.48, P = .007, and r = -.49, P = .006, respectively), between sTNFR-II and transferrin concentration (r = -.53, P = .003), and between In(sTNFR-II) and percent body fat (r = -.37, P < .05), but not between sTNFRs and triglyceride or retinol-binding protein. Thus, sTNFRs are markers for clinical course but not for major metabolic changes in HIV infection.
authors.affiliation: University of Amsterdam, Department of Internal Medicine, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Godfried
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
authors.forename: G J
authors.initials: GJ
authors.lastname: Weverling
authors.forename: E P
authors.initials: EP
authors.lastname: Corssmit
authors.forename: E
authors.initials: E
authors.lastname: Endert
authors.forename: J K
authors.initials: JK
authors.lastname: Eeftinck Schattenkerk
authors.forename: H P
authors.initials: HP
authors.lastname: Sauerwein
mesh_terms: D000328:Adult; D015415:Biomarkers; D001823:Body Composition; D004734:Energy Metabolism; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D012016:Reference Values; D012995:Solubility
chemical_list: D015415:Biomarkers; D018124:Receptors, Tumor Necrosis Factor