[Genetic determination of bone density].
Osteoporosis is a very common disease that concerns every forth postmenopausal white woman. The loss of bone density leads to fractures, mainly to fractures of the neck of the femur. A hereditary genesis of the idiopathic osteoporosis seems to be sure. The vitamin D receptor (VDR) has an important role for the mineralisation of the bones. His allelic variants can be used for a prediction of bone density. These alleles are correlated with endonuclease restriction areas for Bsm-1, Apa-1 and Taq-1. Among these Bsm-1 has the highest incidence for prediction. In this study the allelic variants of the VDR gene correlated with the bone density of the lumbar spine (p < 0.009).
Baltzer
A
A
Orthopädische Klinik- und Poliklinik, Heinrich-Heine-Universität, Düsseldorf.
Reinecke
J
J
Wehling
P
P
Schulitz
K P
KP
Roke
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000378:metabolism; D004720:Endonucleases / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics*; D010865:Pilot Projects; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol; D004720:Endonucleases
Genetische Determinierung der Knochendichte.