title: Normal distribution of apolipoprotein E alleles in progressive supranuclear palsy.
abstract: Apolipoprotein E (Apo E) genotype is a genetic risk factor influencing the development of Alzheimer's disease (AD). Progressive supranuclear palsy (PSP), like AD, is a dementing illness with neurofibrillary tangles. We determined the frequencies of Apo E alleles in 52 PSP patients and 52 age- and gender-matched controls. The distribution of Apo E allele frequencies and genotypes showed no difference between PSP and controls. Apo E allele status does not influence the development of PSP.
authors.affiliation: Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314, USA.
authors.forename: A
authors.initials: A
authors.lastname: Anouti
authors.forename: K
authors.initials: K
authors.lastname: Schmidt
authors.forename: K E
authors.initials: KE
authors.lastname: Lyons
authors.forename: J P
authors.initials: JP
authors.lastname: Hubble
authors.forename: G
authors.initials: G
authors.lastname: Schellenberg
authors.forename: L I
authors.initials: LI
authors.lastname: Golbe
authors.forename: A E
authors.initials: AE
authors.lastname: Lang
authors.forename: N
authors.initials: N
authors.lastname: Galvez-Jimenez
authors.forename: L
authors.initials: L
authors.lastname: Hershey
authors.forename: W C
authors.initials: WC
authors.lastname: Koller
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013494:Supranuclear Palsy, Progressive / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E