title: Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases.
abstract: OBJECTIVE
  To study maternal and fetal outcome of pregnancy in patients with lupus who were exposed to hydroxychloroquine (HCQ).
  
  
  METHODS
  The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus activity, obstetric experience, and infant outcome.
  
  
  RESULTS
  HCQ was not apparently teratogenic. Lupus activity and obstetric outcome in the two groups were similar.
  
  
  CONCLUSIONS
  HCQ continuation is probably safe during pregnancy in patients with lupus, but there is no obvious advantage in commencing treatment.
authors.affiliation: Lupus Pregnancy Clinic, St Thomas' Hospital, London, United Kingdom.
authors.forename: N M
authors.initials: NM
authors.lastname: Buchanan
authors.forename: E
authors.initials: E
authors.lastname: Toubi
authors.forename: M A
authors.initials: MA
authors.lastname: Khamashta
authors.forename: F
authors.initials: F
authors.lastname: Lima
authors.forename: S
authors.initials: S
authors.lastname: Kerslake
authors.forename: G R
authors.initials: GR
authors.lastname: Hughes
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects / Q000627:therapeutic use*; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine