Synthesis and biological activity of a series of isoindolone derivatives related to cytochalasins.
A series of hydrogenated isoindolone derivatives structurally related to cytochalasin B has been synthesized and their ability to induce binucleation in the human lymphocytes were tested. All compounds were found able to inhibit cell cytokinesis at different extent in the range (3.12-25 mumol/l) respect to the negative control; however the highest percentage of binucleated cells is induced by Cyt B.
Pistelli
L
L
Dipartimento di Chimica Bioorganica, Università di Pisa, Italy.
Benassi
S
S
Migliore
L
L
Papa
S
S
Andreassi
M G
MG
D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured; D003571:Cytochalasin B / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male
D007211:Indoles; D003571:Cytochalasin B