title: Glycolipids and myelin proteins in human oligodendrogliomas.
abstract: We studied myelin proteins and glycolipids in 24 human oligodendrogliomas (16 pure, eight mixed), including two grade I, 13 grade II, five grade III, and four grade IV. Tumours with a 1b ganglioside content (GD1b, GT1b and GQ1b) over 30% of total gangliosides occur more frequently in the WHO grade I and II (47%) and grade III (40%) than in the grade IV (25%) group; there was no difference in the amounts of total ganglioside or individual gangliosides between pure and mixed oligodendrogliomas. The presence of 6'-LM1 correlated with higher grades of tumours (chi 2 P approximately 0.02); however, 3'-LM1 and total neolacto-series gangliosides did not correlated with grade. Immunohistochemical studies of oligodendrocyte and myelin markers (GalCer, sulfatide, 2',3' -cyclic nucleotide phosphodiesterase, myelin basic protein and proteolipid protein) using specific antibodies showed only a very small proportion of tumour cells staining. These data do not support the hypothesis that tumours classified as oligodendrogliomas are derived from mature oligodendrocytes.
authors.affiliation: Division of Neuropathology, Ohio State University, Columbus 43210, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Sung
authors.forename: R
authors.initials: R
authors.lastname: Collins
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: D K
authors.initials: DK
authors.lastname: Pearl
authors.forename: S W
authors.initials: SW
authors.lastname: Coons
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: P C
authors.initials: PC
authors.lastname: Johnson
authors.forename: A J
authors.initials: AJ
authors.lastname: Yates
mesh_terms: D001932:Brain Neoplasms / Q000737:chemistry* / Q000473:pathology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005732:Gangliosides / Q000032:analysis* / Q000096:biosynthesis / Q000737:chemistry; D006017:Glycolipids / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D009185:Myelin Proteins / Q000032:analysis*; D019158:N-Acetylneuraminic Acid / Q000032:analysis; D009837:Oligodendroglioma / Q000737:chemistry* / Q000473:pathology*
chemical_list: D005732:Gangliosides; D006017:Glycolipids; D009185:Myelin Proteins; D019158:N-Acetylneuraminic Acid