title: The sepsis syndrome. Definition and general approach to management.
abstract: Sepsis is the systemic response to severe infection in critically ill patients. Sepsis, sepsis syndrome, and septic shock represent the increasingly severe stages of the same disease. Severe sepsis and septic shock occur in persons with preexisting illness or trauma. If sepsis is not diagnosed and treated early, it can become self-perpetuating, and elderly persons, in particular, are at a greater risk of death from sepsis.
authors.affiliation: Department of Medicine, Medical College of Ohio, Toledo, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Bone
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D018836:Inflammation Mediators; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D018836:Inflammation Mediators