Distribution of the inositol trisphosphate receptor in the catfish retina.
Inositol 1,4,5-trisphosphate (InsP3) mobilizes intracellular stored Ca2+ by binding to specific receptors that are similar to the ryanodine receptor of skeletal and cardiac muscle. We have immunolocalized the InsP3 receptor to the inner nuclear layer and limiting membranes of the catfish retina. Immunocytochemistry on dissociated retinal cells further localized the receptor in the horizontal, bipolar and Müller glial cells. Immunostaining of the rat retina localized the InsP3 receptor to the plexiform layers. These data show a different distribution of InsP3 receptor in the catfish retina compared to that of other vertebrates, that may be suggestive of a different functional role for this receptor in different species.
Micci
M A
MA
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555-0641, USA.
Christensen
B N
BN
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D003623:Dark Adaptation / Q000502:physiology; D004591:Electrophoresis, Polyacrylamide Gel; D007059:Ictaluridae / Q000378:metabolism*; D015151:Immunoblotting; D007150:Immunohistochemistry; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012160:Retina / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear