Ectopic induction of cartilage and bone by bovine bone morphogenetic protein using a biodegradable polymeric reservoir.
Two kinds of bone morphogenetic protein (BMP) containing polymeric reservoirs made from poly(lactide-co-glycolide) (PLG) and a mixture of PLG/poly(ethylene glycol) (PEG) (PLG/PEG) were implanted into mice femoral muscles. In the PLG/PEG reservoir with BMP, bone formation was induced within 3 weeks. On the other hand, in the PLG reservoir with BMP scarcely any bone formation could be observed. The results suggest that the carrier system is most important for the development of BMP-induced bone formation and the PLG/PEG reservoir system is available for BMP delivery.
Yamazaki
Y
Y
Department of Plastic and Reconstructive Surgery, Kitasato University, Japan.
Oida
S
S
Ishihara
K
K
Nakabayashi
N
N
D000818:Animals; D001672:Biocompatible Materials; D001846:Bone Development / Q000187:drug effects*; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D002356:Cartilage / Q000254:growth & development*; D002417:Cattle; D004343:Drug Implants; D006133:Growth Substances / Q000008:administration & dosage / Q000494:pharmacology*; D019344:Lactic Acid; D051379:Mice; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D010316:Particle Size; D011092:Polyethylene Glycols; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D051381:Rats
D001672:Biocompatible Materials; C525810:Bmp4 protein, mouse; C525811:Bmp4 protein, rat; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D004343:Drug Implants; D006133:Growth Substances; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols