title: Changes in haematocrit after treatment of uncomplicated canine babesiosis: a comparison between diminazene and trypan blue, and an evaluation of the influence of parasitaemia.
abstract: It has been suggested that the antibabesial drug diminazene causes a rapid decline in haematocrit after treatment of dogs with high Babesia canis parasitaemias, compared with trypan blue. To test this, 19 dogs with clinically mild to moderate, uncomplicated babesiosis were placed in low, moderate or high parasitaemia groups, based on venous parasitaemias, and were allotted randomly to diminazene or trypan blue treatment groups. Haematocrit and parasitaemia were determined before treatment, and at 2, 6, 12, 18 and 24 hours. The drugs were compared for effects on haematocrit and parasite clearance. Changes in haematocrit after treatment were analysed. There were no significant differences between diminazene and trypan blue for haematocrit or parasite clearance. There was no correlation between initial parasitaemia and initial or post-treatment haematocrit. In all dogs, haematocrit fell following treatment. The maximum mean reduction from the baseline (0 h) was 0.046 l/l (range 0.02-0.07 l/l); this most often occurred at 6 or 12 h. The 24 h haematocrit ranged from 70.5-113.6% of baseline (mean absolute haematocrit 0.019 l/l below baseline). All dogs improved clinically during the study period. It was concluded that either diminazene or trypan blue can be safely used to treat dogs with clinically mild or moderate, uncomplicated babesiosis. Parasitaemia need not be taken into account when deciding which antibabesial drug to administer and does not appear to be related to the degree of anaemia.
authors.affiliation: Department of medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
authors.forename: L S
authors.initials: LS
authors.lastname: Jacobson
authors.forename: F
authors.initials: F
authors.lastname: Reyers
authors.forename: W L
authors.initials: WL
authors.lastname: Berry
authors.forename: E
authors.initials: E
authors.lastname: Viljoen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001404:Babesiosis / Q000097:blood / Q000188:drug therapy*; D001831:Body Temperature; D004133:Diminazene / Q000191:economics / Q000627:therapeutic use*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D006400:Hematocrit / Q000662:veterinary*; D018512:Parasitemia / Q000097:blood / Q000188:drug therapy*; D012044:Regression Analysis; D014343:Trypan Blue / Q000191:economics / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000191:economics / Q000627:therapeutic use*
chemical_list: D014344:Trypanocidal Agents; D014343:Trypan Blue; D004133:Diminazene