[Fansidar in the treatment of toxoplasmosis].
Toxoplasmosis chorioretinitis is the most frequent posterior uveitis. Different treatment modes are used for its therapy. Classical is the combination of 50 mg of pyrimethamine with 4 g of sulphadiazine and corticosteroids. In this study the results of treatment with lower doses of pyrimethamine together with long-acting sulphonamide are reported. Twelve patients were treated with Fansidar, combination of 25 mg of pyrimethamine and 500 mg sulphadoxine. The treatment consisted of a loading dose of two tablets of Fansidar, followed by one tablet a day. Prednisone 0.5 mg/kg/day was added and gradually tapered off. Patients were treated for 28 days on average (range 21-50 days). In 83% of patients the scar was considerably smaller than original lesion (on average the scar represented 25% of original lesion). Three months after the treatment the visual acuity was 6/9 or better in 83% of patients. No side-effects of the treatment were observed. Lower doses of pyrimethamine with suphadoxine in an easy once a day treatment regime could be an alternative and cost-effective therapy for ocular toxoplasmosis.
Michalová
K
K
I. ocní klinika 1. LF UK, Praha.
Ríhová
E
E
Havlíková
M
M
D000293:Adolescent; D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008875:Middle Aged; D011739:Pyrimethamine / Q000627:therapeutic use*; D012189:Retrospective Studies; D013413:Sulfadoxine / Q000627:therapeutic use*; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine
Fansidar v lécbĕ ocní toxoplazmózy.