Families of ion channels with two hydrophobic segments.
The family of epithelial sodium channels and nematode degenerins has expanded recently to include a member found only in brain, and another that functions in molluscs as a ligand-gated channel. A new gene family of mammalian ATP-gated channels has been discovered; one of its seven members plays a role in the lysis of macrophages. The mechanosensitive channel of bacteria has emerged as the simplest form of a channel protein subunit with two hydrophobic domains.
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Glaxo Institute for Molecular Biology, 14 chemin des Aulx, Plan-les-Quates, 1228 Geneva, Switzerland. RAN8881@ggr.co.uk
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry* / Q000145:classification*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
D007473:Ion Channels