title: The role of superoxide dismutase in the human ovary and fallopian tube.
abstract: OBJECTIVE
  To investigate the localization of manganese superoxide dismutase (Mn-SOD) and copper-zinc superoxide dismutase (Cu, Zn-SOD) in the human ovary and fallopian tube, and to examine the role of superoxide radicals and SODs in the human ovulatory process.
  
  
  METHODS
  Using immunohistochemical methods, we studied the localization of SODs in 22 human ovaries, in 18 fallopian tubes, and in aspirated granulosa cells. We measured, by enzyme-linked immunosorbent assay, the concentrations of SODs in follicular fluid taken from 94 IVF patients.
  
  
  RESULTS
  Mn-SOD was found in granulosa, in theca and luteal cells and in fallopian tubes. Cu, Zn-SOD was localized in theca and luteal cells. The concentration of Cu, Zn-SOD in follicular fluid in the high-progesterone group (11.3 + 4.2 ng/ml) was significantly less than in the low-progesterone group (24.5 + 19.5) (p < 0.05).
  
  
  CONCLUSIONS
  Mn-SOD and Cu, Zn-SOD have different localizations and actions in human ovaries and fallopian tubes. The superoxide radical-SOD system might play an important role in ovulation and in the luteal function of the human ovary.
authors.affiliation: Department of Obstetrics and Gynecology, Asahikawa Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tamate
authors.forename: K
authors.initials: K
authors.lastname: Sengoku
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
mesh_terms: D001826:Body Fluids / Q000201:enzymology*; D004797:Enzyme-Linked Immunosorbent Assay; D005187:Fallopian Tubes / Q000201:enzymology*; D005260:Female; D006801:Humans; D010053:Ovary / Q000201:enzymology*; D010060:Ovulation / Q000502:physiology; D013482:Superoxide Dismutase / Q000502:physiology*
chemical_list: D013482:Superoxide Dismutase