[The lymphokine-mediated activation of effector cells in the natural resistance system induced by gamma-interferon].
Some mechanisms of biologic action of gamma-interferon (INF) agents have been studied in mice systems in vivo. The obtained results testify to the possibility of existence of inductor mechanisms for activation of the effector cells of immunobiologic surveillance. It is supposed that gamma-INF is a binding chain of the natural host resistance.
Fil'chakov
F V
FV
Fil'chakov
I V
IV
Grinevich
Iu A
IuA
Martynenko
S V
SV
Ivanenko
V K
VK
D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007371:Interferon-gamma / Q000302:isolation & purification / Q000494:pharmacology*; D008163:Luminescent Measurements; D008213:Lymphocyte Activation / Q000187:drug effects*; D008222:Lymphokines / Q000187:drug effects / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D008222:Lymphokines; D011994:Recombinant Proteins; D007371:Interferon-gamma
Limfokin-oposredovannaia aktivatsiia kletok-éffektorov sistemy estestvennoĭ rezistentnosti, indutsirovannaia gamma-interferonom.