Wound healing profiles of ketorolac, metronidazole and tinidazole administered post-surgically.
On dead space wounds, drugs (ketorolac, metronidazole and tinidazole) caused a significant (P < 0.01) decrease in breaking strength, granulation tissue weight and hydroxyproline content in male rats. Both the parameters of excision wound were significantly (P < 0.01) hastened by metronidazole and tinidazole only. Post operative management of wounds with ketorolac (a potent analgesic), metronidazole and tinidazole (for anaerobic infections) may be dealt with the risk of a delay in healing. Both metronidazole and tinidazole promote the epithelization process.
Prasad
D
D
Department of Pharmacology, Kasturba Medical College, Manipal, India.
Rao
C M
CM
D000818:Animals; D006097:Granulation Tissue / Q000187:drug effects; D020910:Ketorolac; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014011:Tinidazole / Q000494:pharmacology*; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
D014011:Tinidazole; D008795:Metronidazole; D014046:Tolmetin; D020910:Ketorolac