title: Determination of oenothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum.
abstract: Several extracts from Epilobium parviflorum, a plant used in Central Europe for the treatment of prostate disorders, were evaluated in a biochemical assay with 5-alpha-reductase. The aqueous extract displaying inhibition of the enzyme was analyzed, the fraction responsible for this activity was purified, and the active compound identified as a macrocyclic tannin, oenothein B (1).
authors.affiliation: Centre de Recherche ROUSSEL UCLAF, Roumainville, France.
authors.forename: D
authors.initials: D
authors.lastname: Lesuisse
authors.forename: J
authors.initials: J
authors.lastname: Berjonneau
authors.forename: C
authors.initials: C
authors.lastname: Ciot
authors.forename: P
authors.initials: P
authors.lastname: Devaux
authors.forename: B
authors.initials: B
authors.lastname: Doucet
authors.forename: J F
authors.initials: JF
authors.lastname: Gourvest
authors.forename: B
authors.initials: B
authors.lastname: Khemis
authors.forename: C
authors.initials: C
authors.lastname: Lang
authors.forename: R
authors.initials: R
authors.lastname: Legrand
authors.forename: M
authors.initials: M
authors.lastname: Lowinski
authors.forename: P
authors.initials: P
authors.lastname: Maquin
authors.forename: A
authors.initials: A
authors.lastname: Parent
authors.forename: B
authors.initials: B
authors.lastname: Schoot
authors.forename: G
authors.initials: G
authors.lastname: Teutsch
mesh_terms: D058891:5-alpha Reductase Inhibitors; D001317:Austria; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D047348:Hydrolyzable Tannins; D066298:In Vitro Techniques; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D011467:Prostate / Q000201:enzymology; D013056:Spectrophotometry, Ultraviolet; D013634:Tannins / Q000032:analysis / Q000494:pharmacology*
chemical_list: D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D047348:Hydrolyzable Tannins; D013634:Tannins; C080077:oenothein B