[Atropine suppresses associative potentiation in the hippocampus].
The effect of the muscarinic antagonist atropine on associative long-term potentiation of the CA1 population EPSPs was studied in rat hippocampal slices. Local application of atropine (10(-4) M) significantly suppressed associative long-term potentiation (40-60 min after the tetanization) in a <<weak>> input (str. Radiatum 128 +/- 10% vs 168 +/- 9% in control, p < 0.03). Long term potentiation in the <<strong>> input itself was not suppressed and even tended to be enhanced by atropine (str. Oriens 158 +/- 4% vs 137 +/- 13 during control). The results suggest that synaptically released endogenous acethylcholine supports induction of long-term potentiation in the synapses with a low level of activation.
Sokolov
M V
MV
Institute of the Brain of the Russian Acad. Med. Sci., Moscow.
Kleshchevnikov
A M
AM
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D003864:Depression, Chemical; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D018727:Muscarinic Antagonists; D001285:Atropine
Atropin podavliaet assotsiativnuiu potentsiatsiiu v gippokampe.