title: Gastric cytoprotective activity of 2-cyclopenten-1-one and related compounds.
abstract: The cytoprotective activity of the isolated functional groups of several sesquiterpene lactones is reported. Among them the highest activity is shown by alpha-methylen-gamma-butyrolactone and 2-cyclopenten-1-one. The activity shown by those Michael acceptors with a beta carbon hindered by an alkyl substituent was always lower or almost null. A three-way mechanism of action is proposed: a) reduced glutathione synthesis, b) prostaglandin synthesis and c) mucosal glycoprotein synthesis.
authors.affiliation: Departmento de Farmacologia, Universidad Nacional de San Luis, Argentina.
authors.forename: A O
authors.initials: AO
authors.lastname: María
authors.forename: G H
authors.initials: GH
authors.lastname: Wendel
authors.forename: T
authors.initials: T
authors.lastname: Guardia
authors.forename: J A
authors.initials: JA
authors.lastname: Guzmán
authors.forename: M J
authors.initials: MJ
authors.lastname: Pestchanker
authors.forename: E
authors.initials: E
authors.lastname: Guerreiro
authors.forename: O S
authors.initials: OS
authors.lastname: Giordano
mesh_terms: D000818:Animals; D003517:Cyclopentanes / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control; D013329:Structure-Activity Relationship
chemical_list: D003517:Cyclopentanes; D005765:Gastrointestinal Agents; C013905:cyclopentenone