Validation of the Banff criteria for acute rejection in renal transplant biopsies.
BACKGROUND
The histological criteria for the diagnosis of mild acute rejection in renal transplant biopsies have not been well defined.


OBJECTIVE
To ascertain the value of the Banff criteria for transplant biopsy reporting, particularly for the diagnosis of acute rejection, and the 'borderline' category.


METHODS
We compared two systems of histological assessment in 23 transplant biopsy specimens and compared histological diagnoses to separately defined clinical diagnoses. The histological criteria applied were those of the recently described Banff criteria which were compared with our traditional diagnostic method for each specimen.


RESULTS
We found the Banff diagnoses more closely related to the clinical outcome than the system of histological diagnosis that we had previously been using.


CONCLUSIONS
We conclude that the Banff criteria more accurately reflect the clinical situation.
Dittmer
I D
ID
Department of Medicine, School of Medicine, University of Auckland, New Zealand.
Zwi
L J
LJ
Collins
J F
JF
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006084:Graft Rejection / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation / Q000473:pathology*; D007683:Kidney Tubular Necrosis, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome