[Effect of local administration of aprotinin on surgical blood loss after myocardial revascularization].
The authors compare three groups of patients operated at the cardiosurgical clinic of the Faculty Hospital in Hradec Králové on account of ischaemic heart disease. Group A comprised 50 patients where for revascularization of the myocardium venous grafts were used, group B comprised 50 patients where also the mammary artery was used/IMA/. The postoperative blood losses are compared and the number of administered blood transfusions in the two groups. Group C is formed by 50 patients where after preparation of the IMA aprotinin/100 000 u./was administered locally. The authors provide evidence that the use of IMA increases significantly the postoperative blood losses/in group A 675 ml +/- 352.9, in group B 1232 ml +/- 336.5/and increases the number of required transfusions/group A 2.44 +/- 1, group B 3.45 +/- 1/. By local aprotinin application to the wound surface during preparation of IMA the authors reduced in group C the blood losses to 896 +/- 231.9 ml and the number of administered transfusions to 2.74 +/- 0.8.
Mandák
J
J
Kardiochirurgická klinika FN, Hradec Králové.
Lonský
V
V
Dominik
J
J
D000287:Administration, Topical; D007611:Aprotinin / Q000008:administration & dosage*; D016063:Blood Loss, Surgical; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries; D008875:Middle Aged; D009204:Myocardial Revascularization
D007611:Aprotinin
Ovlivnĕní krevních ztrát po revaskularizaci myokardu lokální aplikací aprotininu.