title: Neuropharmacology and drug interactions in clinical practice.
abstract: Absorption, distribution, and clearance are key pharmacokinetic principles. These parameters can be highly variable among patients and among compounds, and are factors that must be considered in the wide variability in response to medications. Current antiepileptic drugs (AEDs) present many challenges in their administration. However, understanding and utilizing pharmacokinetic principles can assist the clinician in the appropriate optimization of AEDs.
authors.affiliation: College of Pharmacy, University of Minnesota, Minneapolis 55455, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Graves
mesh_terms: D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001682:Biological Availability; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008433:Mathematics; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants