Comparison of fluconazole and amphotericin B for treatment of experimental Candida albicans endocarditis in rabbits.
Amphotericin B (AmB) and fluconazole, administered intraperitoneally for 7 days, were compared in a rabbit model for Candida albicans endocarditis. When given early, AmB was more effective than fluconazole for reducing CFU counts in vegetations (P < 0.01) and kidneys. Forty-eight hours after the last dose, AmB was still detected in all vegetations whereas fluconazole was detected in only one case.
Chemlal
K
K
Unité 13, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Saint-Julien
L
L
Joly
V
V
Farinotti
R
R
Seta
N
N
Yeni
P
P
Carbon
C
C
D000666:Amphotericin B / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D015169:Colony Count, Microbial; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D015725:Fluconazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006321:Heart / Q000382:microbiology; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000382:microbiology; D011817:Rabbits
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole