title: Mutational analysis of structure-function relationship of RNA polymerase in Escherichia coli.
authors.affiliation: Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Jin
authors.forename: Y N
authors.initials: YN
authors.lastname: Zhou
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D001665:Binding Sites; D002384:Catalysis; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D005798:Genes, Bacterial; D016297:Mutagenesis, Site-Directed; D019384:Nucleic Acid Synthesis Inhibitors / Q000378:metabolism / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D012293:Rifampin / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013728:Terminator Regions, Genetic; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D019384:Nucleic Acid Synthesis Inhibitors; C051799:sorangicin A; C100307:streptolydigin; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin