title: Morphological study on a case of canine hepatic nodular fibrosis.
abstract: Hepatic nodular fibrosis occurred in an 8-year-old male Papillon dog. Fibrous nodules, consisting of broad bands of collagen fibers, spindle cells, and lipofuscin-laden foamy macrophages, were well-circumscribed and frequently linked up with the portal areas. Because the spindle cells were positive for desmin and/or alpha-smooth muscle actin, they might be Ito cells or myofibroblasts. These results suggest that both the spindle cells and macrophages play an important role in the pathogenesis of hepatic nodular fibrosis, which might arise from the portal area.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shiga
authors.forename: K
authors.initials: K
authors.lastname: Shirota
authors.forename: T
authors.initials: T
authors.lastname: Shida
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
mesh_terms: D000199:Actins / Q000032:analysis; D000818:Animals; D015415:Biomarkers; D003094:Collagen / Q000032:analysis; D003893:Desmin / Q000032:analysis; D004283:Dog Diseases; D004285:Dogs; D007150:Immunohistochemistry; D008062:Lipofuscin / Q000032:analysis; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology / Q000662:veterinary*; D008264:Macrophages / Q000473:pathology; D008297:Male
chemical_list: D000199:Actins; D015415:Biomarkers; D003893:Desmin; D008062:Lipofuscin; D003094:Collagen