Implications of cellular and molecular biology advances in periodontal regeneration.
BACKGROUND
The mechanisms by which new periodontium is established on root surfaces previously exposed to periodontal disease has been an area of active research interest for the past decade.


METHODS
Recently, histological examination of periodontal regeneration has revealed a complex process orchestrated by temporo-spatial specific cell-matrix interactions.


RESULTS
Advances in cell and molecular biology techniques have provided invaluable tools to begin investigating the cascade of events occurring periodontal regeneration.


CONCLUSIONS
This report summarizes current understanding of the cellular and molecular aspects of periodontal regeneration and determines the clinical relevance of these findings.
Amar
S
S
Department of Oral Biology and Periodontology, Boston University, Massachusetts.
D000818:Animals; D003094:Collagen / Q000378:metabolism / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000502:physiology; D006023:Glycoproteins / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008967:Molecular Biology; D010513:Periodontal Ligament / Q000166:cytology / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D016207:Cytokines; D006023:Glycoproteins; D006133:Growth Substances; D003094:Collagen