TDT with covariates and genomic screens with mod scores: their behavior on simulated data.
We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.
Rice
J P
JP
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Neuman
R J
RJ
Hoshaw
S L
SL
Daw
E W
EW
Gu
C
C
D003198:Computer Simulation; D005820:Genetic Testing / Q000379:methods*; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008957:Models, Genetic