title: Glioblastoma multiforme in the left frontal lobe subsequent to malignant lymphoma in the right orbit.
abstract: A 62-year-old male presented with glioblastoma multiforme in the left frontal lobe manifesting as motor aphasia, subsequent to a malignant lymphoma in the right orbit. He underwent subtotal removal of the right orbital mass presenting as right exophthalmos which was shown by histological examination to be non-Hodgkin's lymphoma. He received 30 Gy Lineac irradiation to the right orbit. His post-operative course was satisfactory. Magnetic resonance (MR) imaging with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) 7 months later demonstrated a small spotty enhanced lesion in the left frontal lobe. He developed motor aphasia 1 year after irradiation. MR imaging disclosed an enhanced mass in the left frontal lobe, which was totally removed. Histological examination revealed glioblastoma multiforme. Patients with malignant lymphoma may develop a subsequent second malignant tumor. MR imaging with Gd-DTPA is quite useful for early detection of a second brain tumor.
authors.affiliation: Department of Neurosurgery, Shinshiro City Hospital, Aichi.
authors.forename: M
authors.initials: M
authors.lastname: Tomida
authors.forename: M
authors.initials: M
authors.lastname: Muraki
authors.forename: H
authors.initials: H
authors.lastname: Hiramatsu
authors.forename: K
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: K
authors.initials: K
authors.lastname: Hinokuma
authors.forename: K
authors.initials: K
authors.lastname: Uemura
authors.forename: A
authors.initials: A
authors.lastname: Masago
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Mabe
authors.forename: M
authors.initials: M
authors.lastname: Kuroda
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology* / Q000532:radiotherapy; D005625:Frontal Lobe / Q000473:pathology* / Q000528:radiation effects; D005909:Glioblastoma / Q000150:complications* / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000473:pathology* / Q000528:radiation effects; D009918:Orbital Neoplasms / Q000150:complications* / Q000473:pathology* / Q000532:radiotherapy; D011829:Radiation Dosage