Involvement of the p16INK4 (CDKN2) gene in familial melanoma.
Recent work on the molecular genetics of familial melanoma has suggested that the p16 kinase inhibitor gene (CDKN2) is one of the genes causing familial melanoma. Evidence for the candidacy of the p16 gene as a familial melanoma gene is summarized and the characteristics of this class of cell cycle control proteins are reviewed.
Naylor
M F
MF
Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA.
Everett
M A
MA
D002352:Carrier Proteins / Q000235:genetics*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016147:Genes, Tumor Suppressor; D006801:Humans; D008545:Melanoma / Q000235:genetics*
D002352:Carrier Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16