Alterations in T cells of cancer-bearers: whence specificity?
T cells of tumor-bearing mice and cancer patients have been reported to have altered signal-transduction machinery. These alterations have been implicated in immunological suppression. Here, Daniel Levey and Pramod Srivastava critically examine the evidence for these alterations in the context of the tumor specificity of immunological unresponsiveness in tumor-bearing hosts.
Levey
D L
DL
Dept of Biological Sciences, Fordham University, Bronx, NY 10458, USA. Levey@murray.fordham.edu
Srivastava
P K
PK
D000818:Animals; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
D000939:Epitopes