LSD-like panic from risperidone in post-LSD visual disorder.
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors, it is noteworthy that three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. We conclude that HPPD may be a relative contraindication for the use of risperidone.
Abraham
H D
HD
Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA.
Mamen
A
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006212:Hallucinations / Q000139:chemically induced*; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects*; D008297:Male; D016584:Panic Disorder / Q000139:chemically induced*; D018967:Risperidone / Q000009:adverse effects*
D014150:Antipsychotic Agents; D008238:Lysergic Acid Diethylamide; D018967:Risperidone