Angiotensin II-induced structural and functional alterations in spontaneously hypertensive rat kidney.
The purpose of this study was to compare functional and structural changes in the kidneys of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during prolonged administration of angiotensin II. Rats were pretreated with captopril, and the effects of exogenous angiotensin II (200 ng.kg-1.min-1 for 7-14 days sc) on renal hemodynamics and renal vascular structure were examined. Angiotensin II induced significant reductions of renal blood flow and glomerular filtration and increases of renal vascular resistance in SHR but not WKY. Furthermore, angiotensin II induced an increase of the media/lumen ratio in the interlobular arteries (0.33 +/- 0.02 to 0.56 +/- 0.02) and arcuate arteries (0.27 +/- 0.02 to 0.53 +/- 0.07) of SHR without significantly altering the media/lumen ratio in the interlobular arteries (0.34 +/- 0.03 to 0.34 +/- 0.02) and arcuate arteries (0.30 +/- 0.02 to 0.36 +/- 0.05) of WKY (two-factor analysis of variance, strain x treatment; P = 0.0002 for interlobular arteries and P = 0.0319 for arcuate arteries). Results from this study indicate that the SHR kidney is more responsive than the WKY kidney to the functional and structural effects of prolonged angiotensin II infusion.
Kost
C K
CK
Center for Clinical Pharmacology, University of Pittsburgh Medical Center, Pennsylvania 15213-2582, USA.
Herzer
W A
WA
Li
P
P
Notoya
M
M
Mizuhira
V
V
Inagami
T
T
Jackson
E K
EK
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000033:anatomy & histology* / Q000502:physiology*; D011921:Rats, Inbred WKY; D012079:Renal Circulation
D000959:Antihypertensive Agents; D000804:Angiotensin II; D002216:Captopril