title: Influence of physical exercise on aging rats: I. Life-long exercise preserves patterns of spontaneous activity.
abstract: Physical exercise has been shown to delay a number of aging changes and increase life expectancy but not maximum lifespan. We trained male Sprague-Dawley rats in a treadmill from the age of 5 months to 23 months. Up to this age the mortality (19%) was not different from that of the sedentary controls (16%). The body weights of the trained animals remained lower and reached a plateau, while those of the sedentary controls continued to increase. The spontaneous activity was assessed in an open-field setting every second month. Movement parameters (running distance, running speed, percentage of large and local movements), resting time and number of changes of direction were calculated. The running parameters were higher for the trained animals from the age of 12 months onwards, the relative difference increasing all the time. The resting time was lower for the trained animals, while the number of changes of direction did not change. It is suggested that this retardation of decline of spontaneous physical activity is due to a slowing of development of sensorimotor disturbances. These observations are compatible with a better preservation of cholinergic and dopaminergic activity.
authors.affiliation: Institute of Physiology, University of Veterinary Medicine, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Skalicky
authors.forename: H
authors.initials: H
authors.lastname: Bubna-Littitz
authors.forename: A
authors.initials: A
authors.lastname: Viidik
mesh_terms: D017677:Age Distribution; D000375:Aging / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley