title: Dynamic snapshot gradient-echo imaging of head and neck malignancies: time dependency and quality of contrast-to-noise ratio.
abstract: The purpose of this study was to evaluate the time dependency of the contrast-to-noise ratio (CNR) of head and neck malignancies during contrast-enhanced MR imaging. Then we would compare the CNR of dynamic snapshot gradient-echo (SGE) images with conventional spin-echo (SE) and fast spin-echo (FSE) sequences. Fifteen patients with squamous cell carcinomas were examined with T1W-SE, T2W-FSE, contrast-enhanced Gd-T1W-SE, and T1W-SGE sequences, the latter statically and contrast-enhanced dynamically. The CNR for all sequences and adjacent tissues was computed and the time to reach maximal CNR (Tmax) was determined for dynamic studies. The CNR was time dependent with two distinct Tmax at 6-18 and 60-160 s which corresponded to two different tumor enhancement patterns. Neither enhancement pattern correlated with distinct histologic findings or tumor grading. The CNR improved for the Gd-T1W-SE images. The improvement was statistically significant in relation to T1W-SE and Gd-T1W-SE images at the floor of the mouth and at the tongue base. The good CNR of the dynamic Gd-T1W-SGE measurements justifies further investigations of this method in order to improve tumor delineation.
authors.affiliation: Department of Radiology, University Hospital of Basle, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Gückel
authors.forename: K
authors.initials: K
authors.lastname: Schnabel
authors.forename: M
authors.initials: M
authors.lastname: Deimling
authors.forename: W
authors.initials: W
authors.lastname: Steinbrich
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged