[The effect of calponin on the rate of actin filament movement].
The effect of calponin on the velocity of actin filaments sliding over skeletal and phosphorylated smooth myosins was studied by in vitro mobility assay. It was found that calponin, being part of an actin filament, inhibits the average velocity of thin filaments movement. The analysis of histograms of the velocities showed that in the presence of calponin, actin filaments are capable to slow down the sliding, stop moving and move with high velocity, characteristic of calponin-free filaments. Tropomyosin weakens the inhibiting effect of calponin. It is supposed that calponin inhibits the sliding of thin filaments in more "all or none" fashion.
Borovikov
Iu S
IuS
Horiuchi
K Y
KY
Chacko
S
S
D000199:Actins / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002148:Calmodulin-Binding Proteins / Q000494:pharmacology*; D002645:Chickens; D008840:Microfilament Proteins; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009218:Myosins / Q000187:drug effects / Q000502:physiology; D014335:Tropomyosin / Q000494:pharmacology; D000096985:Calponins
D000199:Actins; D002135:Calcium-Binding Proteins; D002148:Calmodulin-Binding Proteins; D008840:Microfilament Proteins; D009218:Myosins; D014335:Tropomyosin; D000096985:Calponins
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