title: Abolition of spindle oscillations by serotonin and norepinephrine in the ferret lateral geniculate and perigeniculate nuclei in vitro.
abstract: The transition from sleep to waking is associated with the abolition of spindle waves in thalamocortical neurons and the GABAergic cells of the thalamic reticular/perigeniculate nuclei. We tested the possibility that norepinephrine (NE) and serotonin (5-HT) may abolish spindle wave generation through an enhancement of the hyperpolarization-activated cation current Ih in thalamocortical neurons. Local application of agents known to enhance Ih, including 5-HT, NE, the adenylyl cyclase activator, forskolin, and the beta-adrenergic agonist, isoproterenol, to lamina A1 of the dorsal lateral geniculate nucleus resulted in an abolition of local spindle wave generation in thalamocortical neurons. The abolition of spindle waves was reversed by the local application of the Ih channel blocker, cesium. These results suggest that NE and 5-HT may abolish the generation of spindle waves through the modulation of Ih in thalamocortical neurons.
authors.affiliation: Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: D A
authors.initials: DA
authors.lastname: McCormick
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002586:Cesium / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D005289:Ferrets; D005829:Geniculate Bodies / Q000187:drug effects / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010507:Periodicity; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D005576:Colforsin; D002586:Cesium; D012701:Serotonin; D007545:Isoproterenol; D009638:Norepinephrine