title: [Brucella endocarditis: role of drug treatment associated with surgery].
abstract: Brucella infective endocarditis is an uncommon, but serious complication of brucellosis. The aortic valve is the most commonly affected cardiac valve, and a fearful complication is the formation of aortic root abscess. Due to the characteristics of the infection, medical therapy alone is not sufficient in treating the disease and best results are achieved in combination with surgery. We describe 2 cases of brucella endocarditis involving the aortic valve. Aggressive treatment, with surgery performed during a period of active infection, produced good results in eradication of infection and in preventing fatal complications such as rupture of aortic root abscesses.
authors.affiliation: Istituto di Cardiochirurgia, Università degli Studi, Bologna.
authors.forename: I
authors.initials: I
authors.lastname: Caldarera
authors.forename: S
authors.initials: S
authors.lastname: Albanese
authors.forename: G
authors.initials: G
authors.lastname: Piovaccari
authors.forename: M
authors.initials: M
authors.lastname: Ferlito
authors.forename: R
authors.initials: R
authors.lastname: Galli
authors.forename: F
authors.initials: F
authors.lastname: Squadrini
authors.forename: A
authors.initials: A
authors.lastname: Pierangeli
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery; D002006:Brucellosis / Q000150:complications* / Q000628:therapy; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline; D012293:Rifampin
vernacular_title: Endocardite da brucella: ruolo del trattamento medico associato a quello chirurgico.