[Effect of estradiol valerate and chlormadinone acetate in hormone replacement therapy in postmenopause on Kupperman index, body weight, blood pressure, lipids, enzymes and electrolytes].
Kupperman-index, weight, blood pressure, serum lipids, blood count, thrombocytes, fibrinogen, thrombine time, electrolytes, enzymes, serum proteins, bilirubine and other parameters were studied in 16 healthy post-menopausal women treated for 18 months with 2 mgs estradiol valerate continuously sequentially combined with the antiandrogenic progestogen chlormadinone acetate (CMA) 2 mgs from 1st to 12th every month of treatment. The women were examined after the 1st, 3rd, 6th, 12th, and 18th month during the last 3 days of the progestogen phase, where the CMA had been added to the estradiol valerate for at least 12 days. The combined estradiol-CMA therapy resulted in a significantly reduced Kupperman-index. The total serum cholesterol- and LDLC-levels were also reduced and the HDL-cholesterol and HDLC-cholesterol-quotient increased. Triglycerides, weight, blood pressure, enzymes, and other parameters were unchanged. The positively metabolic effects of estradiol valerate were not altered after the chlormadinone acetate in a sequential regime.
Göretzlehner
G
G
Kreiskrankenhaus Torgau, Abt. Gynäkol. u. Geburtshilfe.
Nikschick
S
S
Zimmermann
T
T
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002715:Chlormadinone Acetate / Q000008:administration & dosage* / Q000009:adverse effects; D002979:Climacteric / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D015914:Estrogen Replacement Therapy; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008875:Middle Aged
D004573:Electrolytes; D004798:Enzymes; D008055:Lipids; D002715:Chlormadinone Acetate; D004958:Estradiol
Der Einfluss von Estradiolvalerat und Chlormadinonacetat während der Hormonersatztherapie in der Postmenopause auf Kupperman-Index, Körpergewicht, Blutdruck, Lipide, Enzyme und Elektrolyte.