Early steps in mammalian sex determination.
Since the cloning of the Y-located testis-determining factor, sex determining region Y (SRY), several other genes have been implicated in the process of mammalian sex determination. Mutations of an SRY-related gene, SRY-related high-mobility group box 9 (SOX9), result in autosomal sex reversal and campomelic dysplasia. The genes Steroidogenic factor 1 (SF1) and Wilms' tumour 1 (WT1) are required for early gonadal development as well as for the formation of adrenals and kidneys respectively. The gene responsible for adrenal hypoplasia congenita, DAX1, is a candidate for the X-linked dosage sensitive sex reversal gene (DSS).
Ramkissoon
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Y
Department of Genetics, University of Cambridge, UK. ydr@mole.bio.cam.sc.uk
Goodfellow
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P
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D012734:Disorders of Sex Development; D051717:Fushi Tarazu Transcription Factors; D018628:Gene Dosage; D006609:High Mobility Group Proteins / Q000235:genetics*; D018398:Homeodomain Proteins; D006801:Humans; D008322:Mammals; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D055758:SOX9 Transcription Factor; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000235:genetics*; D025721:WT1 Proteins; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D051717:Fushi Tarazu Transcription Factors; D006609:High Mobility Group Proteins; D018398:Homeodomain Proteins; C515057:NR5A1 protein, human; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; D025721:WT1 Proteins