Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2.
Ching
M S
MS
Department of Medicine, University of Melbourne, Austin.
Bichara
N
N
Blake
C L
CL
Ghabrial
H
H
Tukey
R H
RH
Smallwood
R A
RA
D019388:Cytochrome P-450 CYP1A2 / Q000737:chemistry / Q000378:metabolism*; D019389:Cytochrome P-450 CYP2D6 / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D008968:Molecular Conformation; D011433:Propranolol / Q000031:analogs & derivatives* / Q000378:metabolism*
C012878:N-desisopropylpropranolol; C001422:4-hydroxypropranolol; D011433:Propranolol; D019388:Cytochrome P-450 CYP1A2; D019389:Cytochrome P-450 CYP2D6