Mutagenicity of cytostatic drugs in a bacterial system. I. Ames test.
A set of nine cytostatic drugs were tested in the standard plate incorporation method of Ames reversion test using four Salmonella typhimurium his strains. Six of them were classical and commonly used cytostatics, three (cloturin, butocin and oracin) are at different stages of development. The results showed 6-mercaptopurine, cloturin, adriamycin, mitoxantron, cyclophosphamide and lomustine to be mutagenic; butocin, oracin and tris(2-chloroethyl)amine were negative in this test.
Marhan
J
J
Research Institute of Pharmacy and Biochemistry Co. (VUFB), Pardubice-Rosice, Czech Republic.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000633:toxicity*; D001711:Biotransformation; D004354:Drug Screening Assays, Antitumor; D008297:Male; D008862:Microsomes, Liver; D009152:Mutagenicity Tests; D051381:Rats; D017208:Rats, Wistar; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D000970:Antineoplastic Agents