Role of cholecystokinin-B receptor in the maintenance of thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat.
To gain a better understanding of the role of cholecystokinin (CCK)-B receptor in the maintenance of thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat, this study evaluated the effects of intrathecally administered YM022 (a CCK-B receptor antagonist) on thermal hyperalgesia. Drugs were administered intrathecally 1 or 5 weeks after the nerve injury (1 and 5 week study). In the 5 week study, but not the 1 week study, YM022 attenuated the level of thermal hyperalgesia in a dose-dependent manner. These data indicate that a CCK-B receptor antagonist attenuates the level of thermal hyperalgesia and this effect of a CCK-B receptor antagonist is time-dependent.
Yamamoto
T
T
Department of Anesthesiology, Chiba University, Japan.
Nozaki-Taguchi
N
N
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001569:Benzodiazepines / Q000494:pharmacology; D004121:Dimethyl Sulfoxide; D006727:Hormone Antagonists / Q000494:pharmacology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy / Q000503:physiopathology*; D007278:Injections, Spinal; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009408:Nerve Compression Syndromes / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000502:physiology*; D011957:Receptors, Opioid / Q000187:drug effects; D012584:Sciatic Nerve / Q000293:injuries / Q000503:physiopathology* / Q000648:ultrastructure
D006727:Hormone Antagonists; D009292:Narcotic Antagonists; D011949:Receptors, Cholecystokinin; D011957:Receptors, Opioid; D001569:Benzodiazepines; C087260:YM 022; D009270:Naloxone; D004121:Dimethyl Sulfoxide