title: [Photodynamic therapy and breast-plasty of a extensive superficial trunk skin basalioma of the breast. An effective combination therapy with photodynamic diagnosis].
abstract: We treated a large superficial basal cell carcinoma (ca. 10 x 6 cm) on the right breast in a 48-year old woman with photodynamic therapy (PDT). Fractionated PDT was performed by topical application of delta-aminolevulinic acid (delta-ALA, 20%) with subsequent red light (570-750 nm; 180 J/ cm2) in three sessions. Nearly total remission of the tumor resulted; however, a few residual neoplastic islands partly infiltrating the nipple-areola complex could be detected by photodynamic diagnosis (PDD). These fluorescent areas were marked, excised, and the defect was closed by a rotation advancement flap. Total excision of the tumor was verified histologically. By combining PDT and surgery, this large tumor was treated with excellent cosmetic results. This case demonstrates the efficiency of topical PDT with adjunctive plastic surgery controlled by PDD even in large tumors.
authors.affiliation: Hautklinik der Heinrich-Heine-Universität, Düsseldorf.
authors.forename: C
authors.initials: C
authors.lastname: Fritsch
authors.forename: P M
authors.initials: PM
authors.lastname: Becker-Wegerich
authors.forename: K W
authors.initials: KW
authors.lastname: Schulte
authors.forename: W
authors.initials: W
authors.lastname: Neuse
authors.forename: P
authors.initials: P
authors.lastname: Lehmann
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: G
authors.initials: G
authors.lastname: Goerz
mesh_terms: D000287:Administration, Topical; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013524:Surgical Flaps / Q000473:pathology
chemical_list: D000622:Aminolevulinic Acid
vernacular_title: Photodynamische Therapie und Mamillenplastik eines grossflächigen Rumpfhautbasalioms der Mamma. Effektive Kombinationstherapie unter photodynamischer Diagnostik.