title: Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. I. Synthesis and in vitro antimicrobial evaluation.
abstract: A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (9-36) was prepared by a simple synthetic procedure based on the reaction of ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (1-8) and reagents (a-n) containing a primary amino group. When this set of compounds was subjected to "in vitro" antimicrobial screening, it showed no significant activity.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Firenze, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bruni
authors.forename: S
authors.initials: S
authors.lastname: Selleri
authors.forename: A
authors.initials: A
authors.lastname: Costanzo
authors.forename: G
authors.initials: G
authors.lastname: Guerrini
authors.forename: M L
authors.initials: ML
authors.lastname: Casilli
authors.forename: C
authors.initials: C
authors.lastname: Sacco
authors.forename: R
authors.initials: R
authors.lastname: Donato
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011720:Pyrazoles; D011744:Pyrimidinones