Effect of tibial attachment location on the healing of the anterior cruciate ligament freeze model.
We studied the healing response of a devitalized anterior cruciate ligament to a treatment of initial anterior-posterior joint translation in goats. Devitalization and devascularization were achieved by five successive freeze-thaw cycles. Anterior-posterior translation was surgically altered by an osteotomy of the tibial attachment of the devitalized ligament and its reattachment either in the anatomical position or in a position 5 mm posterior. Six weeks after the first surgery, the same procedure was performed on the contralateral limb, except that the ligament was reattached in the alternate position. Six months after the initial surgery, femur-anterior cruciate ligament-tibia specimens were tested to determine their structural and mechanical material properties. Anatomic ligament placement resulted in reduced anterior-posterior translation (p < 0.05) and greater anterior joint stiffness (p < 0.05). Maximum load (p < 0.05) and ligament stiffness (p < 0.01) also were greater for the anatomically placed anterior cruciate ligaments. The maximum load for anatomically placed ligaments averaged 1.625 +/- 211 N (SEM). The strength of the posteriorly placed anterior cruciate ligament, 895 +/- 164 N was similar to results of historical anterior cruciate autograft reconstructions. Ligament failure occurred near the tibial insertion in the posteriorly placed ligaments more often than in the anatomically placed ligaments (four of five times compared with one of five times). Ligament failure near the tibial insertion occurred with lower mean maximum load than failure at the midsubstance or by bone avulsion (796 compared with 1.592 N: p < 0.05). These data support the hypothesis that ligament laxity is important to the healing and remodeling of anterior cruciate ligament grafts.
Bush-Joseph
C A
CA
Cincinnati Sportsmedicine and Orthopaedic Center, Ohio, USA.
Cummings
J F
JF
Buseck
M
M
Bylski-Austrow
D I
DI
Butler
D L
DL
Noyes
F R
FR
Grood
E S
ES
D000818:Animals; D016118:Anterior Cruciate Ligament / Q000033:anatomy & histology / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D046508:Culture Techniques; D005260:Female; D005615:Freezing; D006041:Goats; D013314:Stress, Mechanical; D013977:Tibia / Q000473:pathology*; D016474:Weight-Bearing / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*