title: Constructing aligned sequence blocks.
abstract: This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5' flank of the beta-globin gene.
authors.affiliation: Department of Computer Science and Engineering, Pennsylvania State University, University Park 16802, USA.
authors.forename: W
authors.initials: W
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Boguski
authors.forename: B
authors.initials: B
authors.lastname: Raghavachari
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: R C
authors.initials: RC
authors.lastname: Hardison
mesh_terms: D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D004247:DNA; D004122:Dimethylallyltranstransferase / Q000235:genetics; D004330:Drosophila; D005914:Globins / Q000235:genetics; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D016415:Sequence Alignment; D014981:Xenopus
chemical_list: D005914:Globins; D004247:DNA; D004122:Dimethylallyltranstransferase