Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia.
We report a 47-year-old Japanese woman with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) combined with acute type adult T-cell leukemia (ATL). The susceptibility for HAM/TSP and acute type of ATL is hitherto explained by human leukocyte antigen (HLA) haplotype-linked immune responsiveness to HTLV-I. This patient's HLA (A24Cw1B54DR4DQ4/A24Cw3B51DR8DQ1) included a HAM-associated HLA haplotype. This suggests that HAM patients with HAM-associated HLA haplotype can also develop the acute type of ATL.
Furukawa
Y
Y
Third Department of Internal Medicine, Kagoshima University.
Okadome
T
T
Tara
M
M
Niina
K
K
Izumo
S
S
Osame
M
M
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D015493:Paraparesis, Tropical Spastic / Q000150:complications* / Q000209:etiology* / Q000276:immunology / Q000473:pathology
D006680:HLA Antigens