title: Invasive vulvar carcinoma in two women infected with human immunodeficiency virus.
abstract: This report presents two HIV-infected women who developed invasive squamous cell carcinoma of the vulva. One patient was diagnosed with Stage II vulvar cancer 4 years after surgical excision of VIN. This patient underwent a hemivulvectomy and external-beam radiation therapy, but has subsequently developed recurrent vulvar cancer. The other patient was diagnosed with stage IV invasive vulvar cancer 1 year after the diagnosis of VIN and died of invasive vulvar cancer 11 months later. VIN should be considered a serious condition in HIV-infected women and clinicians should be careful to examine the vulva and perianal region in all HIV-infected women.
authors.affiliation: Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Wright
authors.forename: J P
authors.initials: JP
authors.lastname: Koulos
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: X W
authors.initials: XW
authors.lastname: Sun
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002278:Carcinoma in Situ / Q000150:complications / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012086:Reoperation; D014846:Vulvar Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery