Reconstitution of apoB mRNA editing in liver by gene-transfer as a potential approach for the treatment of severe forms of polygenic hypercholesterolemia--an outline of the rationale.
Greeve
J
J
Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, N.Y. 10461, USA.
Chowdhury
J R
JR
D000818:Animals; D053299:Apolipoprotein B-100; D053283:Apolipoprotein B-48; D001055:Apolipoproteins B / Q000235:genetics*; D001161:Arteriosclerosis / Q000235:genetics / Q000628:therapy; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics / Q000628:therapy*; D017270:Lipoprotein(a) / Q000235:genetics; D008099:Liver / Q000378:metabolism*; D017393:RNA Editing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D013045:Species Specificity
D053299:Apolipoprotein B-100; D053283:Apolipoprotein B-48; D001055:Apolipoproteins B; D017270:Lipoprotein(a); D012333:RNA, Messenger