title: Molecular variants of hepatitis B virus.
abstract: Variation in the genome of hepatitis B virus has been associated with a number of clinical parameters, but there is a paucity of functional data to show a causal relationship. For example, variants of the core and X genes have been linked with the pathogenesis of chronic hepatitis, viral replication efficiency, and serologically negative infections, among other observations. Variants of the surface antigen are linked with infection after vaccination, infection of liver grafts in patients undergoing immunotherapy, and samples that react poorly in diagnostic assays.
authors.affiliation: Institute of Virology, University of Glasgow, Scotland, United Kingdom.
authors.forename: W F
authors.initials: WF
authors.lastname: Carman
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004742:Enhancer Elements, Genetic; D005814:Genes, Viral; D014644:Genetic Variation; D006515:Hepatitis B virus / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D014758:Viral Core Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014758:Viral Core Proteins