[Mechanisms and risk factors of venous thromboembolic disease].
Venous thrombi are composed predominantly of fibrin and red cells with a variable platelet and leukocyte component. They usually form in regions of slow or disturbed flow as in valve cusps, or in venous segments exposed to trauma. Occlusion of the vessel by the thrombus induces venous stasis and extension of the thrombus both proximally and distally. The pathogenic factors that predispose to the occurrence of thrombosis have been described by Virchow: stasis, vascular lesion, and hypercoagulability. Immobilization, cancers, and deficiency of coagulation inhibitors and activated protein C resistance are the most important risk factors of thromboembolic disease.
Emmerich
J
J
Service de médecine vasculaire, Hôpital Broussais, Paris.
D005260:Female; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors; D013923:Thromboembolism / Q000503:physiopathology*; D013924:Thrombophlebitis / Q000503:physiopathology
Mécanismes et facteurs de risque de la maladie veineuse thrombo-embolique.