title: Beta-protein immunoreactivity in the human brain after cardiac arrest.
abstract: Brain of twelve, 44-78 years old non-demented patients affected by total ischemia after cardiac arrest, were used in the study. All of them were resuscitated within a few minutes after cardiac arrest and they survived for 3 to 36 days afterward. In all cases, after cardiac arrest, beta PP overexpression was found by immunocytochemical methods in many cortical and subcortical neurons as well as in ependymal and choroid plexus cells. This overexpression of beta PP, was concomitant with formation of many A beta nonfibrillar (thioflavine-negative) plaques in the neuropil. Because of a break in the blood-brain barrier around many vessels, weakly A beta-immunoreactive material was also found. The data presented provided strong evidence that the total brain ischemia resulting from cardiac arrest is a risk factor for beta-amyloidosis.
authors.affiliation: New York State Institute for Basic Research in Developmental Disabilities, Department of Pathological Neurobiology, Staten Island, NY, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Wiśniewski
authors.forename: D
authors.initials: D
authors.lastname: Maślińska
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000503:physiopathology / Q000648:ultrastructure; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology; D046508:Culture Techniques; D006323:Heart Arrest / Q000150:complications*; D006801:Humans; D008875:Middle Aged
chemical_list: D016229:Amyloid beta-Peptides