title: DNA ploidy patterns in androgen-deprived localized prostate cancer.
abstract: Prostatectomy was performed in 48 patients with localized prostate cancer. Before surgery, they had been treated with the GnRH agonist triptorelin for 3 months. Specimens from the largest tumor focus (n = 6.3 + 3.6, mean + SD) were analyzed with regard to the DNA ploidy pattern. The results were compared with those obtained in a previous investigation of 54 patients who were subjected to surgery without hormone pretreatment. In both series, about 50% of the tumors showed a diploid DNA ploidy pattern, the rest being nondiploid. Ploidy heterogeneity, i.e., a mixture of diploid and nondiploid ploidy patterns in the single largest tumor focus, was found in 36% of the cases compared to 48% in the previous report (NS). In 13% of the tumors, all samples revealed a nondiploid DNA ploidy pattern as compared to 6% in the previous report (NS). In both series, needle biopsy examination (1/patient) prior to prostatectomy was associated with a significant and similar underestimate of the chromosomal aberration. In conclusion, despite the marked histopathological changes previously reported, there is no evidence that neoadjuvant triptorelin treatment during 3 months has any effect on the DNA ploidy pattern.
authors.affiliation: Department of Urology, Karolinska, Institutet, Danderyd Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Hellström
authors.forename: K
authors.initials: K
authors.lastname: Wester
authors.forename: M
authors.initials: M
authors.lastname: Häggman
authors.forename: S
authors.initials: S
authors.lastname: Brändstedt
authors.forename: C
authors.initials: C
authors.lastname: Busch
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D017373:Cyproterone Acetate / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
chemical_list: D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D004273:DNA, Neoplasm; D017329:Triptorelin Pamoate; D017373:Cyproterone Acetate