Why mammalian cell surface proteins are glycoproteins.
Most proteins presented at the external surface of mammalian cells contain carbohydrate. The reason for this is not fully understood, but recent work has shown that such carbohydrate has two major functions. Inside the cell, it helps proteins fold and assembly correctly in the endoplasmic reticulum, and it might also act as a signal for the correct migration of glycoproteins. Outside the cell, it provides specific recognition structures for interaction with a variety of external ligands.
Gahmberg
C G
CG
Department of Biosciences, University of Helsinki, Finland.
Tolvanen
M
M
D000818:Animals; D001692:Biological Transport; D002135:Calcium-Binding Proteins / Q000378:metabolism; D037281:Calnexin; D037282:Calreticulin; D002240:Carbohydrate Sequence; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; D012261:Ribonucleoproteins; D037281:Calnexin