Delayed hypersensitivity at the injection sites of a low-molecular-weight heparin.
We report a case of delayed hypersensitivity to a low-molecular-weight heparin. The patient presented with eczema at the site of subcutaneous injections and allergy tests confirmed the clinical diagnosis. There were positive tests with 3 low-molecular-weight heparins and unfractionated subcutaneous calcium heparin but negative with intravenous sodium heparin. Although delayed hypersensitivity to low-molecular-weight heparins is rare, the possibility of cross-allergy to unfractionated heparin could be a therapeutic problem for some patients.
Moreau
A
A
Department of Dermatology of Caen, France.
Dompmartin
A
A
Esnault
P
P
Michel
M
M
Leroy
D
D
D004485:Eczema / Q000139:chemically induced; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008875:Middle Aged; D010328:Patch Tests
D006495:Heparin, Low-Molecular-Weight