Hepatic amino acid transport.
Significant progress has been made in the molecular characterization of the hepatic amino acid transport systems, processes that play a key role in hepatocellular functions such as gluconeogenesis and glycogen formation, and the response of the hepatocyte to injury. Several amino acid transporters have been cloned, and regulation of hepatic amino acid transport under normal and pathophysiologic conditions can now be examined in greater detail. Recent work on the hepatic amino acid transport systems is reviewed, and the clinical implications of these findings, if known, are discussed.
Moseley
R H
RH
Department of Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA.
D026905:Amino Acid Transport Systems; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*
D026905:Amino Acid Transport Systems; D000596:Amino Acids; D002352:Carrier Proteins