title: Colon perforation after lung transplantation.
abstract: BACKGROUND
  Colon perforation has been previously described after solid organ transplantation. Since the inception of the lung transplant program at the University of Colorado 60 isolated lung transplantations have been performed. Four of these patients have suffered spontaneous colonic perforation.
  
  
  METHODS
  The case history of each lung transplant patient with a colon perforation and the literature were reviewed.
  
  
  RESULTS
  An increased incidence of colon perforation in lung transplant patients was identified. Diverticulitis was found to be the predominant cause, and an association with steroids was noted. The two deaths in this series were in patients receiving high-dose steroids in whom invasive Aspergillus infections developed.
  
  
  CONCLUSIONS
  Careful screening of the gastrointestinal tract before transplantation is advocated. A steroid-sparing immunosuppressive regimen is recommended. All lung transplant patients with abdominal complaints require an aggressive work-up, and surgeons should have a low threshold for laparotomy. Conservative surgical principles, including resection of the perforated segment of colon and proximal end-colostomy rather than primary anastomosis, are necessary for the optimal outcome.
authors.affiliation: Division of General and Cardiothoracic Surgery, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Beaver
authors.forename: D A
authors.initials: DA
authors.lastname: Fullerton
authors.forename: M R
authors.initials: MR
authors.lastname: Zamora
authors.forename: D B
authors.initials: DB
authors.lastname: Badesch
authors.forename: D
authors.initials: D
authors.lastname: Weill
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
authors.forename: D N
authors.initials: DN
authors.lastname: Campbell
authors.forename: F L
authors.initials: FL
authors.lastname: Grover
mesh_terms: D000328:Adult; D003108:Colonic Diseases / Q000209:etiology*; D004239:Diverticulitis, Colonic / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007416:Intestinal Perforation / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care
chemical_list: D007166:Immunosuppressive Agents