title: AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.
abstract: An early step in the initiation of polyomavirus DNA replication is viral large-T-antigen-mediated unwinding of the origin. We report that components of the AP1 transcription factor, Fos and Jun, interact with T antigen in vitro to enhance unwinding of the viral origin. This provides a biochemical basis for the capacity of AP1 to activate viral DNA replication in vivo.
authors.affiliation: Department of Biochemistry, University of Missouri--Columbia 65202, USA.
authors.forename: W
authors.initials: W
authors.lastname: Guo
authors.forename: W J
authors.initials: WJ
authors.lastname: Tang
authors.forename: X
authors.initials: X
authors.lastname: Bu
authors.forename: V
authors.initials: V
authors.lastname: Bermudez
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.forename: W R
authors.initials: WR
authors.lastname: Folk
mesh_terms: D000957:Antigens, Viral, Tumor / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D016761:Oncogene Proteins v-fos / Q000378:metabolism / Q000494:pharmacology; D010544:Peroxidases; D054464:Peroxiredoxins; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism / Q000494:pharmacology; D014157:Transcription Factors / Q000378:metabolism* / Q000494:pharmacology; D014779:Virus Replication / Q000235:genetics*
chemical_list: D000957:Antigens, Viral, Tumor; D004279:DNA, Viral; D016761:Oncogene Proteins v-fos; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D010544:Peroxidases; D054464:Peroxiredoxins