title: The inositol triphosphate receptor family.
abstract: Specific receptors on intracellular membranes mediate the Ca2+ mobilization induced by the second messenger molecule D-myo-inositol 1,4,5-triphosphate (IP3). Most cell types appear to contain multiple receptor isoforms. The review summarizes recent progress on IP3 receptor biology with a particular emphasis on distinctive structural and regulatory features of the individual isoforms.
authors.affiliation: Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA. josephs@jeflin.tju.edu
authors.forename: S K
authors.initials: SK
authors.lastname: Joseph
mesh_terms: D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D003001:Cloning, Molecular; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D015640:Ion Channel Gating; D008024:Ligands; D046911:Macromolecular Substances; D011487:Protein Conformation; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008024:Ligands; D046911:Macromolecular Substances; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium