Determination of activity for nociceptin in the mouse vas deferens.
The recently discovered neuropeptide nociceptin was found to inhibit electrically induced contractions of the mouse vas deferens. Nociceptin and its 14-Tyr analog were each partial agonists, but with high affinity (ED50 of 20 nM). This activity was not opioid in nature, as it was not inhibited by either selective or non-selective opiate antagonists.
Berzetei-Gurske
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Department of Neuroscience, SRI International, Menlo Park, CA 94025, USA.
Schwartz
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Toll
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009292:Narcotic Antagonists / Q000494:pharmacology; D018847:Opioid Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000819:agonists; D014649:Vas Deferens / Q000187:drug effects*; D000097629:Nociceptin
D009292:Narcotic Antagonists; D018847:Opioid Peptides; D011957:Receptors, Opioid; D000097629:Nociceptin