Sib-based detection of QTLs.
Association and transmission/nontransmission analyses were used in a split sample design to identify disease susceptibility alleles at two loci. Sib-pair analysis on various subsets of the data identified an additional four regions that yielded signals of disease predisposing quantitative trait loci (QTLs). Three of these four regions represented Type I errors. A new simulation indicates that a multiplex sampling strategy would substantially improve QTL detection for this oligogenic transmission model.
Suarez
B K
BK
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hampe
C L
CL
O'Rourke
D
D
Van Eerdewegh
P
P
Reich
T
T
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D018740:Genetic Heterogeneity; D005819:Genetic Markers; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D009679:Nuclear Family; D012984:Software
D005819:Genetic Markers