Coexistence of Fos protein and proopiomelanocortin mRNA in hypothalamic arcuate nucleus following electroacupuncture.
The immediate early gene, c-fos encodes a nuclear phosphoprotein, Fos which has been proposed to be a third messenger to regulate the expression of specific target genes. The present work demonstrated the coexistence of Fos protein and proopiomelanocortin (POMC) mRNA in the hypothalamic arcuate nucleus (Arc) using techniques of in situ hybridization and immunocytochemistry. The results suggest the activation of beta-endorphinergic (beta-EP) neurons in the Arc by electroacupuncture (EA) and the possible involvement of Fos in modulating POMC expression.
Zhang
J
J
Department of Neurobiology, State Laboratory of Medical Neurobiology, Shanghai Medical University, China.
Wang
M
M
He
L
L
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D015671:Electroacupuncture; D007031:Hypothalamus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin