title: A brute force dichotomization approach to quantitative trait linkage analysis.
abstract: The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed.
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Bailey
authors.forename: L
authors.initials: L
authors.lastname: Almasy
mesh_terms: D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D010641:Phenotype; D011237:Predictive Value of Tests; D012984:Software