Modified substrates of DNA polymerases and design of antivirals.
The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.
Krayevsky
A A
AA
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Alexandrova
L A
LA
Dyatkina
N B
NB
Kukhanova
M K
MK
Shirokova
E A
EA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D003854:Deoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006678:HIV / Q000187:drug effects / Q000502:physiology; D006801:Humans; D019384:Nucleic Acid Synthesis Inhibitors; D012190:Retroviridae / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D003854:Deoxyribonucleotides; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D004259:DNA-Directed DNA Polymerase