title: Successful twin pregnancy in homozygous beta-thalassemia after ovulation induction with growth hormone and gonadotropins.
abstract: OBJECTIVE
  To describe infertility treatment and pregnancy outcome in a patient with transfusion-dependent beta-thalassemia major and hypopituitarism.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University-affiliated infertility clinic.
  
  
  METHODS
  Twenty-four-year-old infertile patient with homozygous beta-thalassemia.
  
  
  METHODS
  Co-treatment with GH and gonadotropins.
  
  
  RESULTS
  Ovulation induction with clomiphene citrate or gonadotropins alone was unsuccessful. Combined treatment with hMG, hCG, and recombinant human GH followed by intrauterine insemination resulted in a viable twin pregnancy.
  
  
  CONCLUSIONS
  Human GH as an adjunct to hMG and hCG seems to be a sensible approach in the treatment of infertile homozygous beta-thalassemic patients among which very few pregnancies are reported.
authors.affiliation: University Hospital, Basel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Surbek
authors.forename: A
authors.initials: A
authors.lastname: Koller
authors.forename: N
authors.initials: N
authors.lastname: Pavic
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use; D006720:Homozygote; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011248:Pregnancy Complications; D011272:Pregnancy, Multiple; D011994:Recombinant Proteins; D014427:Twins; D017086:beta-Thalassemia / Q000235:genetics* / Q000503:physiopathology
chemical_list: D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins; D008596:Menotropins; D013006:Growth Hormone