[The histophysiological characteristics of ovarian development with an altered level of thymic peptides at infancy in mice].
Thymic peptides effect on the female gonad development was studied: consequences of these substances dysbalance in infancy (T-activine administration of 0.1 microgram/g of body weight in dose since 8 to 21 postnatal day) was analysed. Morphofunctional diagnostics of the ovarian state is based on the spontaneous organism reaction to the drug administration (to 21-days-old animals) and on the distant consequences of its activity (in 1-, 2-, 3-months female animals). Thymic peptides dysbalance in infancy promotes only transitory disorders of the ovarian histophysiology, expressing in transitory inhibition of the follicle genesis with the simultaneous atretic process activation, which results in puberty delay with the following complete restoration of reproductive function. Taking into account that in the early neonatal period gonad reacts to T-activine administration with the development of strong ovarian pathology, the results obtain allow to conclude that the reactivity to thymic peptides content oscillations reduces so as the significance of the factors cited in the ovarian morphogenesis regulation in proportion with the animals' maturity.
Butorina
O G
OG
Donskova
M D
MD
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D005260:Female; D051379:Mice; D008854:Microscopy, Electron; D010053:Ovary / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D010455:Peptides / Q000187:drug effects / Q000494:pharmacology / Q000502:physiology*; D012741:Sexual Maturation / Q000187:drug effects / Q000502:physiology; D013949:Thymus Extracts / Q000494:pharmacology; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Gistofiziologicheskie osobennosti razvitiia iaichnika v usloviiakh izmeneniia soderzhaniia timicheskikh peptidov v infantil'nom vozraste u mysheĭ.