A polysomnographic study of sleep disturbance in community elderly with self-reported environmental chemical odor intolerance.
Subjective sleep complaints and food intolerances, especially to milk products, are frequent symptoms of individuals who also report intolerance for low-level odors of various environmental chemicals. The purpose of the present study was to evaluate the objective nature of nocturnal sleep patterns during different diets, using polysomnography in community older adults with self-reported illness from chemical odors. Those high in chemical odor intolerance (n = 15) exhibited significantly lower sleep efficiency (p = .005) and lower rapid-eye-movement (REM) sleep percent (p = .04), with a trend toward longer latency to REM sleep (p = .07), than did those low in chemical intolerance (n = 15), especially on dairy-containing as compared with nondairy (soy) diets. The arousal pattern of the chemical odor intolerant group differed from the polysomnographic features of major depression, classical organophosphate toxicity, and subjective insomnia without objective findings. The findings suggest that community elderly with moderate chemical odor intolerance and minimal sleep complaints exhibit objectively poorer sleep than do their normal peers. Individual differences in underlying brain function may help generate these observations. The data support the need for similar studies in clinical populations with chemical odor intolerance, such as multiple chemical sensitivity patients and perhaps certain veterans with "Persian Gulf Syndrome."
Bell
I R
IR
Department of Psychiatry, University of Arizona Health Sciences Center, Tucson, USA.
Bootzin
R R
RR
Ritenbaugh
C
C
Wyatt
J K
JK
DeGiovanni
G
G
Kulinovich
T
T
Anthony
J L
JL
Kuo
T F
TF
Rider
S P
SP
Peterson
J M
JM
Schwartz
G E
GE
Johnson
K A
KA
D000368:Aged; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D003611:Dairy Products / Q000009:adverse effects; D015577:Geriatric Assessment; D006801:Humans; D007206:Individuality; D008892:Milk / Q000009:adverse effects; D018777:Multiple Chemical Sensitivity / Q000175:diagnosis / Q000178:diet therapy / Q000503:physiopathology*; D009812:Odorants; D017286:Polysomnography; D011930:Reaction Time / Q000502:physiology; D012792:Shyness; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000178:diet therapy / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology; D012903:Smell / Q000502:physiology; D014851:Wakefulness / Q000502:physiology