title: Antiinflammatory C-glucosyl chromone from Aloe barbadensis.
abstract: A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
authors.affiliation: Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284-7760, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Hutter
authors.forename: M
authors.initials: M
authors.lastname: Salman
authors.forename: W B
authors.initials: WB
authors.lastname: Stavinoha
authors.forename: N
authors.initials: N
authors.lastname: Satsangi
authors.forename: R F
authors.initials: RF
authors.lastname: Williams
authors.forename: R T
authors.initials: RT
authors.lastname: Streeper
authors.forename: S T
authors.initials: ST
authors.lastname: Weintraub
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000302:isolation & purification* / Q000494:pharmacology; D003436:Croton Oil; D004431:Ear, External / Q000473:pathology; D008401:Gas Chromatography-Mass Spectrometry; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal; D013056:Spectrophotometry, Ultraviolet
chemical_list: C100862:8-(2-O-cinnamoyl(glucopyranosyl))-2-(2-hydroxypropyl)-7-methoxy-5-methylchromone; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D003436:Croton Oil