title: Reversible cerebral perfusion abnormalities associated with cyclosporine therapy in orthotopic liver transplantation.
abstract: A 60-yr-old woman experienced several episodes of generalized seizures following 2 wk of immunosuppressive therapy with cyclosporine for orthotopic liver transplantation. CT showed low density in the white matter of the parieto-occipital lobes. A 99mTc-HMPAO brain SPECT showed diminished perfusion in the parieto-occipital cortex bilaterally. Although the cyclosporine was discontinued, the patient's neurologic status initially worsened and then improved over the next several days. Repeat perfusion brain SPECT showed resolution of most of the perfusion abnormalities, while repeat CT showed persistent white matter changes in the parieto-occipital lobes. We report the presence of reversible cortical perfusion abnormalities in conjunction with cyclosporine therapy. The findings suggest that perfusion brain SPECT may be a sensitive monitor of cyclosporine-induced neurotoxicity.
authors.affiliation: Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lorberboym
authors.forename: D J
authors.initials: DJ
authors.lastname: Bronster
authors.forename: M
authors.initials: M
authors.lastname: Lidov
authors.forename: N
authors.initials: N
authors.lastname: Pandit
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D016031:Liver Transplantation; D008875:Middle Aged; D009778:Occipital Lobe / Q000098:blood supply; D015609:Organotechnetium Compounds; D010091:Oximes; D010296:Parietal Lobe / Q000098:blood supply; D012640:Seizures / Q000139:chemically induced*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D016572:Cyclosporine