title: Left-ventricular unloading with a new pulsatile assist device: the HIA-VAD system and its influence on myocardial stunning.
abstract: To assess the mechanical unloading properties of a new pneumatic cardiac assist device (60 ml Medos HIA-VAD) and its possible influence on recovery from myocardial stunning we performed a study in 12 anaesthetized sheep. After left thoracotomy measuring transducers were placed and the assist device connected between the left-atrial appendage and the descending thoracic aorta. Global hemodynamics were measured before and after unloading was performed. Myocardial stunning was induced by transient occlusion of a coronary artery for 15 minutes and regional myocardial wall thickening was measured. A group without unloading served as controls (group I, n = 4). In a second group unloading was performed during the last ten minutes of ischemia (group II, n = 4) and in a third group unloading was performed for 30 minutes starting after ten minutes of reperfusion (group III, n = 4). After starting the Medos HIA-VAD, significant unloading could be demonstrated: left-ventricular dP/dtmax decreased significantly (p < 0.05) to 54% and 61% in groups II and III and left-atrial pressure to 50% and 71%, respectively. Systolic and mean arterial pressure did not change significantly (p > 0.05), while the diastolic pressure increased (p < 0.05) to 134% and 138% in groups II and III. After mechanical unloading whether during ischemia or during reperfusion systolic wall thickening in the postischemic area recovered to 103% and 92% of preischemic control in groups II and III, respectively. Recovery was incomplete in the non-unloaded controls (76%) (p < 0.05 versus groups II and III). Post-ejection thickening, a diastolic measure of stunning, diminished significantly after unloading in both protocols (p < 0.05 for groups II and III versus group I). We conclude that mechanical unloading with the 60 ml Medos HIA-VAD significantly improves recovery from myocardial stunning.
authors.affiliation: Department of Cardiac Surgery and Centre for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium.
authors.forename: F R
authors.initials: FR
authors.lastname: Waldenberger
authors.forename: E
authors.initials: E
authors.lastname: Pongo
authors.forename: B
authors.initials: B
authors.lastname: Meyns
authors.forename: W
authors.initials: W
authors.lastname: Flameng
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D005069:Evaluation Studies as Topic; D005260:Female; D006353:Heart-Assist Devices; D006439:Hemodynamics; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D017682:Myocardial Stunning / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D012756:Sheep