Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus.
A chemically defined medium was developed which satisfies the nutritional needs of the Streptomyces hygroscopicus strain producing the immunosuppressant rapamycin. More than a doubling of rapamycin biosynthesis was observed on addition of 57 mmol/L of exogenous shikimate. The previously observed inhibition of the synthesis by phenylalanine was not reversed by shikimate.
Fang
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Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA.
Demain
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D007166:Immunosuppressive Agents / Q000378:metabolism*; D010649:Phenylalanine / Q000494:pharmacology; D011090:Polyenes / Q000378:metabolism*; D012765:Shikimic Acid / Q000494:pharmacology*; D020123:Sirolimus; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism
D007166:Immunosuppressive Agents; D011090:Polyenes; D012765:Shikimic Acid; D010649:Phenylalanine; D020123:Sirolimus