[The characteristics of homologous DNA recombination in somatic cells. III. Intrachromosomal recombinations of the aminoglycoside phosphoribosyltransferase gene in transgenic mice].
Intrachromosomal homologous recombination has been revealed in the DNA from transgenic mice of three pedigrees. The recombination DNA of aminoglycosid phosphoribosiltransferase (neo) gene was observed in liver, kidney, spleen, heart, skeletal muscle, germinal glands and tail. It is concluded that the constructed model can be used for studying recombinations in cells of various organs and tissues both in the course of embryogenesis and during their malignant transformation and tumor progression.
Shvemberger
I N
IN
Ermilov
A N
AN
Smagina
L V
LV
Ginkul
L B
LB
Romanov
S R
SR
Glebov
O K
OK
D000818:Animals; D001483:Base Sequence; D002875:Chromosomes / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D010430:Pentosyltransferases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D004247:DNA; D010430:Pentosyltransferases; C082048:aminoglycoside phosphoribosyltransferase
Izuchenie osobennosteĭ gomologichnoĭ rekombinatsii DNK v somaticheskikh kletkakh. III. Vnutrikhromosomnye rekombinatsii gena aminoglikozidfosforiboziltransferazy u transgennykh mysheĭ.