Inhibitory effects of lanostane-type triterpene acids, the components of Poria cocos, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Pachymic acid, 3-O-acetyl-16 alpha-hydroxytrametenolic acid, and poricoic acid B had been isolated from the sclerotium of Poria cocos Wolf. These compounds showed a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. At 0.2 mumol/mouse, these compounds markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).
Kaminaga
T
T
College of Pharmacy, Nihon University, Chiba, Japan.
Yasukawa
K
K
Kanno
H
H
Tai
T
T
Nunoura
Y
Y
Takido
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000287:Administration, Topical; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors; D014315:Triterpenes / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010936:Plant Extracts; D014315:Triterpenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate