title: In vitro activity of ceftizoxime, ceftazidime, cefuroxime, ceftriaxone, cefotaxime, and penicillin against Streptococcus pneumoniae as determined by three quantitative methods.
abstract: E-test, broth microdilution, and agar dilution susceptibility tests were used to evaluate penicillin and five extended-spectrum cephalosporins against 196 strains of Streptococcus pneumoniae with different levels of penicillin resistance. Oxacillin disk tests corresponded to minimum inhibitory concentrations of penicillin determined by the E-test better than those generated by broth microdilution or agar dilution methods. Relative potency of the study drugs was as follows: cefotaxime = ceftriaxone > penicillin > cefuroxime > ceftizoxime > ceftazidime.
authors.affiliation: Clinical Microbiology Institute, Tualatin, Oregon 97062, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
mesh_terms: D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D015296:Ceftizoxime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D002511:Cephalosporins; D010406:Penicillins; D002443:Ceftriaxone; D002442:Ceftazidime; D015296:Ceftizoxime; D002439:Cefotaxime; D002444:Cefuroxime