title: Visualization by magnetic resonance imaging of focal cartilage lesions in the excised mini-pig knee.
abstract: This study showed that magnetic resonance imaging can be used to visualize partial thickness cartilage lesions, 0.7 x 10 mm in area and 0.5 mm in depth, surgically induced in the femur (femoropatellar compartment) of a mini-pig knee joint. Formalin-fixed joints, intact as well as disarticulated, were studied by high resolution imaging using a 2.35 T, 31 cm horizontal-bore superconducting magnet. The two-dimensional and three-dimensional spatial resolutions achievable were as follows: 0.12 x 0.23 mm (two-dimensional) and 0.35 x 0.35 x 0.35 mm (three-dimensional) for the intact joint, and 0.08 x 0.08 mm (two-dimensional) and 0.14 x 0.14 x 0.27 mm (three-dimensional) for the disarticulated joint. These results demonstrate that magnetic resonance imaging, together with edge detection and volume rendering, can be used to visualize focal cartilage lesions.
authors.affiliation: Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge, School of Clinical Medicine, England.
authors.forename: H L
authors.initials: HL
authors.lastname: Koh
authors.forename: H L
authors.initials: HL
authors.lastname: Kshirsaggar
authors.forename: N J
authors.initials: NJ
authors.lastname: Herrod
authors.forename: T A
authors.initials: TA
authors.lastname: Carpenter
authors.forename: L D
authors.initials: LD
authors.lastname: Hall
authors.forename: E B
authors.initials: EB
authors.lastname: Hunziker
authors.forename: J A
authors.initials: JA
authors.lastname: Tyler
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D007718:Knee Injuries / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D013552:Swine; D014945:Wound Healing / Q000502:physiology